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Chemistry: molecular biology and microbiology August inventions list 08/09

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
08/27/2009 > patent applications in patent subcategories. inventions list

20090215022 - Extra-capillary fluid cycling system and method for a cell culture device: An extra-capillary fluid cycling unit for maintaining and cycling fluid volumes in a cell culture chamber includes a housing and a first flexible reservoir extra-capillary fluid reservoir disposed in the housing. The extra-capillary fluid reservoir is in fluid communication with a cell culture chamber. A second flexible reservoir is also... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090215024 - Biomarkers upregulated in prostate cancer: Biomarkers are identified by analyzing gene expression data using support vector machines (SVM) to rank genes according to their ability to separate prostate cancer from normal tissue. Proteins expressed by identified genes are detected in patient samples to screen, predict and monitor prostate cancer.... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20090215023 - High temperature flow-through device for rapid solubilization and analysis: Devices and methods for thermally lysing of biological material, for example vegetative bacterial cells and bacterial spores, are provided. Hot solution methods for solubilizing bacterial spores are described. Systems for direct analysis are disclosed including thermal lysers coupled to sample preparation stations. Integrated systems capable of performing sample lysis, labeling... Agent: Woodcock Washburn LLP

20090215026 - Method for storing tetrazolium compound, stabilizer used in the same, and tetrazolium compound reagent solution using the method: A method for storing a tetrazolium compound stably is provided. The tetrazolium compound is stored in the presence of sodium azide. The tetrazolium compound (A) and the sodium azide (B) are present at a ratio (A:B) in the range from 1:0.02 to 1:6.2. Furthermore, when the tetrazolium compound is stored... Agent: Hamre, Schumann, Mueller & Larson, P.c.

20090215025 - Small peptidic and peptido-mimetic affinity ligands for factor viii and factor viii-like proteins: The present invention pertains to compounds that show a high affinity to Factor VIII and Factor VIII-like proteins, and their uses. The compounds are characterized by the general Formula B-Q-X, wherein B represents a dipeptide, tripeptide, or a peptidomimetic; Q represents a spacer and X represents an anchoring molecule; Q... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090215030 - Method: A method for detecting pathogens, particularly organisms associated with sexually transmitted diseases, especially Human papilloma virus genotypes is described. The method involves the use of real-time PCR using specially designed probes. The probes, kits for carrying out the method, and methods for designing primers suitable for use in the method... Agent: K&l Gates LLP

20090215027 - Method and system for colorimetric determination of a chemical or physical property of a turbid medium: A new method and a system for the simultaneous determination of a biological, chemical and/or physical property of a plurality of individual samples of a turbid is described. The invention relates to a system and colorimetric method for simultaneous determination and measuring properties, such as acidification or pH value, redox... Agent: Hunton & Williams LLP Intellectual Property Department

20090215028 - Methods and compositions for determining anti-hiv drug susceptibility and replication capacity of hiv: This invention relates, in part, to methods and compositions for determining the susceptibility of an HIV to an anti-HIV drug or the replication capacity of an HIV. In certain embodiments, the methods comprise culturing a host cell in the presence of the anti-HIV drug, measuring the activity of the indicator... Agent: Jones Day

20090215029 - Methods of isolating and purifying nucleic acid-binding biomolecules and compositions including same: The invention provides methods for isolating or purifying a biomolecule directly or indirectly bound to a region of interest of a nucleic acid in a cell, and methods for isolating or purifying a biomolecule that directly or indirectly binds to a region of interest of a nucleic acid in a... Agent: Pillsbury Winthrop Shaw Pittman LLP

20090215057 - Analysis molecule and method for the analysis of a nucleotide position in a nucleic acid: The invention relates to an analysis molecule for the analysis of one or more nucleotide positions in a nucleic acid. The positions are in a first state or an alternative second state. The invention further relates to methods that include the use of the analysis molecule. The invention further relates... Agent: Kriegsman & Kriegsman

20090215032 - Analyte detection using barcoded polymers: The invention relates to methods and systems for identifying, quantitating and/or analyzing analytes from samples. The analytes may be organic or inorganic in nature and include but are not limited to pathogens such as viruses.... Agent: Wolf Greenfield & Sacks, P.c.

20090215056 - Assay for methylation in the gst-pi gene: A diagnostic or prognostic assay is disclosed for a disease of condition characterized by abnormal methylation of cytosine at side or sites within the glutathione-S-transferase (GST) Pi gene and/or its regulatory flanking sequences (e.g., prostate cancer and liver cancer). The assay comprises: (i) isolating DNA from said subject, and (ii)... Agent: Sughrue Mion, Pllc

20090215065 - Atlastin: The present invention relates to methods and compositions of a novel gene and the peptide encoded by the gene. Mutations in the gene, named atlastin, are factors in the disease Hereditary Spastic Paraplegia and related disorders. The present invention will be used for the in the research, diagnosis and treatment... Agent: Casimir Jones, S.c.

20090215062 - Composition and method for sequencing nucleic acid: A composition for sequencing DNA is provided and comprises a nuclease and a nuclease-resistant sequencing primer. A method of preparing DNA for sequencing and a method of sequencing DNA are also provided. The method of sequencing DNA can comprise contacting amplification reaction products with the composition under conditions in which... Agent: Life Technologies Corporation C/o Intellevate

20090215052 - Composition for permeabilizing the walls of microorganisms comprising the combination of ethylenediaminetetraacetic acid (edta) and polyethyleneimine (pei): The present invention relates to a composition for permeabilizing the walls of microorganisms, comprising the combination of polyethyleneimine (PEI) and ethylenediaminetetraacetic acid (EDTA), and to a method using said composition for counting and detecting, in a targeted manner, the microorganisms on a membrane. The invention also relates to a kit... Agent: Nields, Lemack & Frame, Llc

20090215037 - Dynamically expressed genes with reduced redundancy: This invention relates to the identification and use of a subset of transcribed genes, wherein the expression of genes in the subset are able to classify cells among a plurality of classes. Methods for the identification or selection of such subsets are provided, along with computer implemented means for the... Agent: Patentique Pllc

20090215036 - Genetic alterations useful for the response prediction of malignant neoplasia to taxane-based medical treatments: The invention provides novel compositions, methods and uses, for the diagnosis, prognosis, prediction, prevention and aid in treatment of malignant neoplasia such as breast cancer, ovarian cancer, gastric cancer, colon cancer, esophageal cancer, mesenchymal cancer, bladder cancer or non-small cell lung cancer. Genes that are chromosomally amplified in breast tissue... Agent: Siemens Corporation Intellectual Property Department

20090215055 - Genetic brain tumor markers: The invention relates to method of genetic analysis for the prediction of treatment sensitivity and survival prognosis of patients with brain tumors, especially oligodendroglial tumors. The invention provides a method for producing a classification scheme for oligodendroglial tumors comprising the steps of a) providing a plurality of reference samples, said... Agent: The Webb Law Firm, P.c.

20090215060 - High throughput methods for sampling seeds: A high-throughput method is provided for analyzing individual seeds in a population of seeds. The method generally includes removing a tissue sample from at least one or more seeds in the population of seeds while preserving germination viability of the at least one or more seeds from which the tissue... Agent: Harness, Dickey & Pierce, P.L.C

20090215040 - Human autism susceptibility gene encoding a transmembrane protein and uses thereof: The present invention discloses the identification of a human autism susceptibility gene, which can be used for the diagnosis, prevention and treatment of autism and related disorders, as well as for the screening of therapeutically active drugs. The invention more specifically discloses that the ATP2B2 gene on chromosome 3 and... Agent: Occhiuti Rohlicek & Tsao, LLP

20090215039 - Investigations: A method of investigation a sample is provided, the sample being a mixture of DNA arising from more than one source. The method includes analysing the sample to obtain a genotype for the DNA present in the sample and assigning a prior probability distribution to the genotype. The likelihood function... Agent: Merchant & Gould Pc

20090215066 - Method and assay for early diagnosis of prostate cancer: A method and assay are described for determining prostate cancer and the general stage of progression of such cancer by quantifying levels of promoter methylation of gal-3, optionally in combination with the quantification of the level of GSTP1 promoter methylation, where the method and assay are non-invasive to a subject... Agent: Intellectual Property / Technology Law

20090215034 - Method for selectively detecting subsets of nucleic acid molecules: Method for selectively detecting nucleic acid molecules comprising structural aberrations that are capable of being convented into nicks comprising generating linear nucleic acids from a selected nucleic acid substrate population; denaturing and re-annealing the linear nucleic acids to form nucleic acid duplexes; masking the nucleic acid duplex termini and internal... Agent: Traskbritt, P.c.

20090215035 - Method of assessing cancerous conditions and reagent for detecting gene product to be used in the method: It is intended to provide a method of assessing cancerous conditions, which is useful in diagnosing cancer in a therapy or a preventive therapy for cancer diseases or a maintenance therapy therefor, and a reagent for detecting a gene product to be used in the above method. The cancerous conditions... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20090215048 - Method of in-silico improvement of organisms using the flux sum of metabolites: The present invention relates to an in silico method for improving an organism on the basis of the flux sum (φ) of metabolites, and more particularly to a method for screening key metabolites that increase the production yield of a useful substance, the method comprising defining the metabolite utilization of... Agent: Intellectual Property / Technology Law

20090215045 - Methods and compositions for vitamin k epoxide reductase: The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphism is correlated with increased or decreased sensitivity to warfarin, thereby identifying... Agent: Myers Bigel Sibley & Sajovec

20090215061 - Methods and compositions for vitamin k epoxide reductase: The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphism is correlated with increased or decreased sensitivity to warfarin, thereby identifying... Agent: Myers Bigel Sibley & Sajovec

20090215058 - Methods for screening, predicting and monitoring prostate cancer: Biomarkers are identified by analyzing gene expression data using support vector machines (SVM) to rank genes according to their ability to separate prostate cancer from normal tissue. Expression products of identified genes are detected in patient samples, including prostate tissue, serum, semen and urine, to screen, predict and monitor prostate... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20090215047 - Methods of detecting viability-associated molecules: A method of detecting a molecule associated with viability of one or more cells or organisms in a sample comprises the initial step of contacting the sample with an enzyme, which enzyme is capable of adding or removing a chemical moiety to or from a nucleic acid molecule in the... Agent: Andrus, Sceales, Starke & Sawall, LLP

20090215059 - Molecular diagnosis of bacteremia: A highly specific assay can be used for the detection of bacteremia in the clinical setting. The ubiquitous background endogenous DNA present in all PCR reagents is eliminated using a restriction endonuclease digestion. Universal primers for eubacteria are used for detection, and specific primers or probes for bacterial species can... Agent: Banner & Witcoff, Ltd.

20090215041 - Multiple snp for diagnosing colorectal cancer, microarray and kit comprising the same, and method of diagnosing colorectal cancer using the same: Provided is a multiple single nucleotide polymorphism (SNP) for colorectal cancer diagnosis, a microarray and a kit including a polynucleotide having the SNP, and a method of diagnosing colorectal cancer using the SNP. Early diagnosis of incidence or possibility of colorectal cancer can be effectively performed by using the method.... Agent: Cantor Colburn, LLP

20090215031 - Mutants of mycobacteria and process thereof: The present invention provides mutant Mycobacterium strains harboring a modified tyrosine phosphatase gene (mptpA or mptpB) wherein the mutant Mycobacterium strain is incapable of expressing the active tyrosine phosphatase. The invention provides a method for developing the said mutant strain from either Mycobacterium tuberculosis or Mycobacterium bovis. The mptpA or... Agent: Merchant & Gould Pc

20090215051 - Novel assay: The invention relates to a translational recoding reporter construct comprising: a first fluorescent protein coding sequence; a second fluorescent protein coding sequence encoding a fluorescent protein different from the first fluorescent protein; and a linker sequence interposed between the first and second fluorescent protein coding sequence; wherein the a first... Agent: Greenlee Winner And Sullivan P C

20090215067 - Novel lipids for transfection of nucleic acids: Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided.... Agent: Proskauer Rose LLP

20090215049 - Novel litaf binding site peptides and methods of using the same: The invention provides molecules containing nucleic acid sequences for fragments of LPS-induced TNF-α factor (LITAF) and vectors containing these sequences. Also provided are molecules that contain the peptide sequence SQTWREPGAAGSPFHL, or homologs thereof. Such molecules may be useful in the treatment of diseases that relate to the expression of TNF-α,... Agent: Clark & Elbing LLP

20090215042 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis: Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.... Agent: Winston & Strawn LLP Patent Department

20090215046 - Novel nucleotide and amino acid sequences, and assays methods of use thereof for diagnosis of colon cancer: Novel markers for colon cancer that are both sensitive and accurate. These markers are overexpressed in colon cancer specifically, as opposed to normal colon tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of colon... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20090215063 - Phosphospecific pak antibodies and diagnostic kits: The present invention relates to the use of phosphorylated p21-activated protein kinases (PAK), especially PAK4, as biomarkers of tumorogenesis. The present invention contemplates the use of phosphospecific antibodies for detecting phosphorylated PAK from mammalian biopsies, as well as screening assays for identifying compounds that modulate PAK activity. Also contemplated is... Agent: Pfizer Inc

20090215043 - Polymorphic ghsr nucleic acids and uses thereof: The present invention relates to methods and compositions for predicting the risk of obesity. In particular, the present invention provides methods and compositions for determining a subject's risk of obesity based on the presence of polymorphisms in the growth hormone secretagogue receptor (GHSR).... Agent: Casimir Jones, S.c.

20090215033 - Prediction of clinical outcome using gene expression profiling and artificial neural networks for patients with neuroblastoma: A method of predicting the outcome of a patient with neuroblastoma that includes obtaining experimental data on gene selections. The gene selection functions to predict the outcome of a patient with neuroblastoma when the expression of that gene selection is compared to the identical selection from a non-neuroblastoma cell or... Agent: Merchant & Gould Pc

20090215038 - Prediction of metastasis: The present invention relates to the prediction of metastasis by determining RKIP expression levels, and to products and kits adapted for such methods. In some embodiments, the present invention relates to methods of assigning a treatment or monitoring regime to a cancer patient according to the level of RKIP expression.... Agent: Morgan Lewis & Bockius LLP

20090215054 - Prognosis indicators for solid human tumors: The present teachings provide methods for predicting the clinical outcome of the treatment of human solid tumors. In some embodiments, the method includes measuring in the cells of a tumor the expression level of a set of genes whose change is related to chromosomal instability; taking a statistical measure of... Agent: K&l Gates LLP

20090215064 - Quantitative assessment of individual cancer susceptibility by measuring dna damage-induced mrna in whole blood: Heparinized human whole blood from patients with invasive breast cancer, with (multiple primary) and without (single primary) a second primary cancer, and from unaffected controls was stimulated with 0.1-10 Gy of radiation and incubated at 37° C. for 2 hours. P21 and PUMA mRNA were then quantified. The results suggest... Agent: Knobbe Martens Olson & Bear LLP

20090215044 - Receptor in dendritic cells: GPBAR1 for use as a target for selective inhibition of Th1 mediated immune responses.... Agent: Novartis Corporate Intellectual Property

20090215050 - Systems and methods for point-of-care amplification and detection of polynucleotides: Compositions and methods for amplifying and detecting solution-state polynucleotide targets in a single device are described. In one aspect, a method for a coupled isothermal amplification and detection process utilizes a coated solid support, including a solid substrate, a cationic layer, and a plurality of target-specific probes attached to the... Agent: Brinks Hofer Gilson & Lione

20090215068 - Thermostable proteinases from thermophilic bacteria: The present invention relates to the preparation of a method for the preparation of nucleic acid samples, including the steps of adding at least one non-specific thermophilic enzyme to a sample containing nucleic acid for testing, and incubating said sample for a preferred period at 65-80° C. as required to... Agent: Morrison & Foerster LLP

20090215053 - Vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method: The present invention relates to the prognosis of the outcome of a cancer in a patient, which prognosis is based on the quantification of one or several biological markers that are indicative of the presence of, or alternatively the level of, the adaptive immune response of said patient against said... Agent: Fulbright & Jaworski L.l.p.

20090215074 - Detection of the nucleolar channel system of human endometrium and uses thereof: Methods are disclosed for assaying at the light microscopic level for the presence or absence of nucleolar channel systems (NCSs) in an endometrial tissue sample, as are methods for determining whether or not a postovulatory human endometrium is in a state that is receptive for implantation of a human embryo,... Agent: Amster, Rothstein & Ebenstein LLP

20090215078 - Doxorubicin immunoassay: Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are useful in immunoassays for the quantification and monitoring of doxorubicin in biological fluids.... Agent: Gibbons P.c.

20090215070 - Highly sensitive immunoassays and antibodies for detection of blood factor viii: Disclosed are antibodies that selectively bind to blood coagulation factor FVIII, and highly sensitive immunological assays comprising these antibodies. Preferred assays can detect FVIII at about 3500-fold below the normal physiological levels, and have a wide array of applications including accurate monitoring of FVIII concentration in pharmaceutical products for treatment... Agent: Edwards Angell Palmer & Dodge LLP

20090215073 - Layered peptide/antigen arrays - for high-throughput antibody screening of clinical samples: A method and composition for the identification of biomolecule in a sample are disclosed. The method comprises obtaining a coated capture membrane stack comprising a plurality of capture membranes with each capture membrane coated with a different peptide. The membrane stack is exposed to a sample, and, after a given... Agent: Jonathan E. Grant

20090215072 - Methods and compositions related to determination and use of white blood cell counts: Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or... Agent: Fulbright & Jaworski LLP

20090215076 - Methods and substances for the diagnosis and therapy of sepsis and sepsis-like systemic infections: Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers in the diagnosis of sepsis.... Agent: Millen, White, Zelano & Branigan, P.c.

20090215077 - Methods for diagnosis of acute coronary syndrome: Provided are methods for the detection and diagnosis of acute coronary syndrome or ACS. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of ACS. At least two new... Agent: Foley And Lardner LLP Suite 500

20090215071 - Methods of targeting baff: The present disclosure provides compositions and methods relating to the structure of BAFF in solution. The disclosure includes BAFF 60-mers, BAFF trimers, methods of making BAFF 60-mers and BAFF trimers, antibodies that preferentially bind one form or the other, and methods of identifying or evaluating a compound on the basis... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090215069 - Pancreatic polypeptide as target/marker of beta cell failure: The present invention relates to the monitoring of disease progression and diagnosis of beta-cell failure in diabetes by measuring levels of pancreatic hormone in a liquid sample, and to screening for novel compounds for the prevention and/or treatment of diabetes.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20090215075 - Three-dimensional structure of a dnab-family replicative helicase (g40p), uses thereof, and methods for developing anti-bacterial pathogens by inhibiting dnab helicases and the interactions of dnab helicase with primase: Structure and methods associated with the three-dimensional structure of G40P helicase and other structure models of any DnaB-like helicase obtained by computer modeling that bears similarity with a root-mean-square deviation (RMSD) of 2.0 with at least one of the three domain structures (N-globe, alpha-hairpin and the C-terminal ATPase domains). In... Agent: Greenberg Traurig LLP (la)

20090215079 - Method and devices for the detection of microorganisms and/or the activity thereof: In a method for detection of microorganisms and/or their activity with biosensors, on a surface of a substrate over portions thereof at least one ligand for binding a receptor or at least one receptor for a ligand or at least one ligand for binding a receptor and at least one... Agent: Gudrun E. Huckett Draudt

20090215084 - B7-h1 and b7-h4 in cancer: Methods of determining prognosis of a subject with cancer or determining risk of cancer progression by assessing expression of B7-H4, or B7-H1 and B7-H4 in combination.... Agent: Fish & Richardson P.c.

20090215085 - Proteomic fingerprinting of human ivf-derived embryos: identification of biomarkers of developmental potential: The present invention discloses biomarkers and biomarker combinations that have prognostic value as predictors of the developmental potential of individual IVF-derived human embryos. In particular, the biomarkers of this invention are useful to classify an embryo with implantation competence after uterine transfer or implantation incompetence. In addition, the biomarkers can... Agent: Wilmerhale/dc

20090215083 - Selecting, culturing and creating lineage committed hematopoietic stem cells: The present invention provides a method for selecting hematopoietic stem cells (HSCs) comprising providing an agent which binds to α9β1 integrin on the cell surface to a population of cells including HSCs and separating HSCs by virtue of the binding agent. The invention also provides a method of culturing a... Agent: Bozicevic, Field & Francis LLP

20090215086 - Biomarkers for babesia: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying babesia status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with babesia or not infected with babesia. The biomarkers can be detected by SELDI mass... Agent: Fenwick & West LLP

20090215087 - Toxoplasma gondii oocyst protein: Recombinant proteins have been developed for the detection of Toxoplasma gondii oocyst proteins for example in biological fluids. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of... Agent: Usda, Ars, Ott

20090215089 - Compositions and methods for identifying and targeting cancer cells of alimentary canal origin: Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of for treating and preventing metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed.... Agent: Pepper Hamilton LLP

20090215091 - Diagnostic panel of cancer antibodies and methods for use: The invention provides a method for detection of a malignancy in a specimen of bodily fluid. The method comprises contacting the specimen with at least two antigens selected from the group consisting of p53, IGFBP2, Topo2α, cathepsin D, cyclin B, cyclin D1, MUC1, HER-2/neu and CEA. The method further comprises... Agent: Karen S. Canady Canady & Lortz LLP

20090215090 - Ercc1 expression in predicting response for cancer chemotherapy: The present invention concerns an in vitro method for detecting the susceptibility of a tumor cell to a chemotherapy, said method comprising the step of the measurement of the ERCC1 protein by immunohistochemistry in a formalin-fixed paraffin-embedded tumor sample.... Agent: Trego, Hines & Ladenheim, Pllc

20090215088 - Tagged ligands for enrichment of rare analytes from a mixed sample: Method of enriching specific cells from cellular samples are disclosed, comprising contacting in solution a cellular sample with affinity-tagged ligands (ATLs) each comprising a first ligand linked to an affinity tag, wherein the ligand selectively binds a cellular marker of the rare cells and the affinity tag can be selectively... Agent: Wilson Sonsini Goodrich & Rosati

20090215092 - Antibodies for anthrax: A targeted approach is described for the production of biological recognition elements capable of fast, specific detection of anthrax spores on biosensor surfaces. Single chain antibodies (scFvs) are produced to EA1, a Bacillus anthracis S-layer protein that is also present, although is not identical, in related Bacillus species. These antibodies... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20090215080 - Methods for identification of inhibitors of enzyme activity: The invention discloses compositions and methods of synthesis to create novel ligands and drugs and identifying such compounds as inhibitors of enzyme targets for use in the treatment of clinical disorders, including cancer, infectious diseases, parasitic infestations, neurological disorders, reproductive disorders, inflammatory disorders, circulatory disorders, and metabolic disorders.... Agent: Bell & Associates

20090215093 - Compounds for enzyme inhibition: Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the... Agent: Ropes & Gray LLP

20090215081 - Screening method for anticancer drug: The screening method for an anticancer drug comprises selecting a compound which blocks the kinase activity of TNIK, or blocks the combination of TNIK with β-catenin/TC4 transcription complex.... Agent: Griffin & Szipl, Pc

20090215082 - Doxorubicin immunoassay: Novel conjugates of doxorubicin and novel doxorubicin immunogens derived from the 13 and 14 positions of doxorubicin and antibodies generated by these doxorubicin linked immunogens all of which are useful in immunoassays for the quantification and monitoring of doxorubicin in biological fluids.... Agent: Gibbons P.c.

20090215094 - Diagnosis and monitoring of chronic renal disease using ngal: A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as... Agent: Hasse & Nesbitt Llc

20090215095 - Compositions and methods for measuring levels of bioactive human hepcidin: The invention provides compositions and methods for measuring human serum hepcidin levels. The invention provides methods for the oxidative refolding of a hepcidin polypeptide to a form that is mature, bioactive and folded as in the native configuration and molecular mass; a method for measuring the level of native, bioactive... Agent: Morrison & Foerster LLP

20090215096 - Collodial silica particle containing light-absorbing susbstance, nano light-absorbing material,absorption labeling nanobead kit, and method for detection or quantification of biological molecule using the colloidal silica particle containing light-absorbi: A colloidal silica particle containing a light-absorbing substance, comprising a colloidal silica particle and a light-absorbing substance distributed over the colloidal silica particle, wherein the light-absorbing substance is chemically bound to or adsorbed on a silica component.... Agent: Birch Stewart Kolasch & Birch

20090215097 - Novel polymer and method of measuring cholesterol therewith: (wherein, R4 represents an alkyl group, a haloalkyl group or a bornyl group), an alkyl group, an alkoxy group, an aralkyl group or an alkylcarbamoyl group; particularly, in the direct measurement of cholesterols such as HDL, LDL and VLDL contained in the sample, the reagent for determining cholesterol in the... Agent: Hamre, Schumann, Mueller & Larson, P.c.

20090215099 - Method of identifying cancer biomarkers and cancer progression: An efficient method for identifying important cancer biomarkers and identifying progression of bladder cancer using pro-u-PA as a clinical tool is provided. Searching for biomarkers critical for bladder carcinoma diagnosis and prognosis, secreted proteomes of highly malignant U1 and pre-malignant U4 cell lines are first analyzed. Proteins in the cultured... Agent: Sinorica, Llc

20090215098 - Quantification of enzyme activity by mass spectrometry: The disclosure relates to methods of quantitatively analyzing the enzymatic activity of enzymes in samples containing a plurality of enzymes, using mass spectrometry. Isotopically labeled standards are employed. Purified enzymes and enzymes from crude cell lysates may be analyzed using the disclosed methods. As little as 0.02 pg of cell... Agent: Marshall, Gerstein & Borun LLP

20090215100 - Process for producing sugar chain derivative, structure analysis method, and sugar chain derivative: A process for preparing an oligosaccharide derivative from an oligosaccharide mixture, the process being characterized in that the process comprises the steps of (a) introducing a lipophilic group into oligosaccharides of the mixture to obtain a mixture of oligosaccharide derivatives, and (b) treating the oligosaccharide derivative mixture by serotonin affinity... Agent: Kubovcik & Kubovcik

20090215101 - Hcv protease substrates: The present invention features HCV NS3 protease substrates containing a europium label and a quenching group. The europium label and quenching group are located on different sides of an ester HCV NS3 protease cleavage site. The substrate can be used in a time-resolved fluorescence (TRF) assay to measure HCV protease... Agent: Merck And Co., Inc

20090215102 - Method to assess breast cancer risk: We show that urinary metalloproteinases (MMP's) (e.g. MMP 9) and a disintegrin and metalloprotease 12 (ADAM 12) are significantly elevated in women at high risk for developing breast cancer and that monitoring for the absence or presence of both MMP 9 and ADAM 12 represents a new means for breast... Agent: Wolf Greenfield & Sacks, P.c.

20090215103 - Generation and use of a catalog of polypeptide-related information for chemical analyses: A method (100) for performing chemical analyses includes digesting a reference sample to obtain precursors associated with a peptide in the sample (110), separating the precursors to determine values associated with retention times of the separated precursors (120), ionizing the separated precursors to form precursor ions (130), mass analyzing the... Agent: Waters Technologies Corporation C/o Waters Corporation

20090215107 - Activator for transient receptor potential vanilloid 2 comprising probenecids: The present invention relates to a method for activation of TRPV2 (transient receptor potential vanilloid 2) using probenecid, more precisely a method for selecting a candidate for TRPV2 blocker using probenecid. Probenecid of the present invention works on TRPV2 specifically so that it facilitates the isolation of sensory neurons expressing... Agent: Greenlee Winner And Sullivan P C

20090215109 - Apparatus and method for measuring luminescence and fluorescence of transfected cells or organ parts: An apparatus for measuring photon emissions from marked cells. The apparatus has the following components: a rotatable, at least partly transparent growth chamber/bioreactor (10) for accommodation of cell cultures, growth media and active substances; a light detector for detection of the photons emitted from the marked cells from the growth... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090215104 - Bioreactor device, and method and system for fabricating tissues in the bioreactor device: A bioreactor device, and a method and system for fabricating tissues and growing cells and tissues in the bioreactor device, accommodates less than about 1 mL (or less than about 200 μL) of local medium volume but sample sizes of about 100 μL or greater. The bioreactor device includes a... Agent: Edwards Angell Palmer & Dodge LLP

20090215106 - Method for detecting intracellular interaction between biomolecules: The present invention relates to a quantitative non-microscopic method of detecting intracellular interactions between biomolecules, on living cells, in response to a biological or pharmacological stimulation, by a time-resolved proximate energy transfer effect between two members of a fluorescence donor/acceptor pair.... Agent: Millen, White, Zelano & Branigan, P.c.

20090215108 - Methods of analyzing a biological sample: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and 3′-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivative compounds having one or more benzo nitrogens.... Agent: Jeffrey A. Mckinney, J.d., Ph.d.

20090215105 - Tetraazaporphyrin-based compounds and their uses: Asymmetrically substituted metal-phthalocyanine compounds are disclosed. These compounds and other phthalo-cyanine-derivatives are used in bioimaging, bioanalysis, FRET and quenching techniques, photodynamic therapy, DNA analysis for cells, proteins, tissues and other biological entities, and other applications. Near-infrared fluorescence minimizes matrix effects typically seen in other methods of analyzing biochemical entities in... Agent: Patent Department Taylor, Porter, Brooks & Phillips, L.l.p

20090215110 - Water monitoring systems: The invention relates to a continuous water monitoring system, including components thereof, and a method relating thereto for continuously monitoring, in real-time, a water supply in order to detect contaminants therein. The system employs the use of a live culture of bioluminescent bacteria and suitable light detecting means.... Agent: King & Schickli, Pllc

20090215111 - Analysis of steroid hormones in thin tissue sections: Mass-spectrometry based methods of analyzing estrogens and other steroids from biological tissue sections samples are disclosed herein. Methods of detecting a disease state or condition or elevated risk of a disease state or condition in a mammal from tissue sections are also disclosed.... Agent: Woodcock Washburn LLP

20090215112 - Tissue sample preprocessing methods and devices: To preprocess a tissue sample, a first permeable mesh membrane is tautly stretched out over the tissue sample and overlaid on top of a flat surface. This covering sandwiches and secures the tissue sample in between the first permeable mesh membrane and the flat surface. If it is desired to... Agent: George Mason University Office Of Technology Transfer, Msn 5g5

20090215113 - Methods for purifying pertussis toxin and peptides useful therefor: The present invention relates to reagents and methods for purifying pertussis toxin (PT).... Agent: Patrick J. Halloran

20090215118 - D-aminoacylase: A D-aminoacylase produced by a microorganism of genus Defluvibacter; which acts on a N-acetyl-D-amino acid; which has a molecular weight (as determined by electrophoresis) of about 55,000 daltons, and an isoelectric point (as determined by two-dimensional electrophoresis for denatured system) of 5.3; which acts on N-acetyl-D-valine, N-acetyl-D-leucine, and the like,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20090215116 - Identification of a beta-1,3-n-acetylgalactosaminyltransferase (cgte) from campylobacter jejuni lio87: The invention relates to β-1,3-N-acetylgalactosaminyltransferase polypeptides, nucleic acids that encode the polypeptides, and methods of using the polypeptides.... Agent: Townsend And Townsend And Crew, LLP

20090215114 - Method of enzymatically synthesizing 3' -phosphoadenosine-5' -phosphosulfate: The invention provides a method for producing 3′-phosphoadenosine 5′-phosphosulfate (PAPS), the method including subjecting ATP to sulfation and phosphorylation by use of adenosine 5′-triphosphate sulfurylase (ATPS) and adenosine 5′-phosphosulfate kinase (APSK), wherein an adenosine 5′-triphosphate (ATP) supply/regeneration system including adenosine 5′-monophosphate (AMP), polyphosphate, polyphosphate-driven nucleoside 5′-diphosphate kinase (PNDK), and polyphosphate:AMP... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20090215115 - Sialyltransferases comprising conserved sequence motifs: The present invention provides, e.g., sialyltransferase proteins comprising conserved sequence motifs, including α-2,3-sialyltransferase proteins from C. jejuni strains O:36 and O:19. The invention also provides methods of making sialylated products using those sialyltransferases.... Agent: Townsend And Townsend And Crew, LLP

20090215117 - Site specific incorporation of keto amino acids into proteins: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids... Agent: Quine Intellectual Property Law Group, P.c.

20090215119 - Methods for producing specific binding pairs: Provided are improved methods for providing specific binding pairs (SBPs). The methods enable production of libraries of SBP members using both a large population of one member of the SBPs and a smaller, preselected population of the other member of the SBPs having affinity for a preselected target.... Agent: Lando & Anastasi, LLP

20090215120 - The use of protein s fusion for protein solubilization: The invention provides vectors containing a multiple cloning site comprising a PrS tag or a PrS2 tag from Myxococcus xanthus. Methods are provided for enhancing solubility of a target protein using Protein S tagged target fusion proteins.... Agent: Patent Docket Administrator Lowenstein Sandler Pc

20090215121 - Process for preparing high levels of interferon beta: The present invention relates to a novel process for the production of interferon-beta in improved yields by fermentation.... Agent: Ladas & Parry LLP

20090215122 - Process for producing thioredoxin: e

20090215123 - Method for producing continuous cell lines: The present invention relates to a method for production of continuous cell lines comprising providing living cells of an animal or a human, irradiating said cells with UV light, proliferating said cells and selecting multiplying cells as cells of a continuous cell line.... Agent: Marshall, Gerstein & Borun (baxter)

20090215125 - Devices and processes for nucleic acid extraction: Devices, processes, and kits for the extraction of nucleic acids from biological samples are disclosed. The devices comprise a first port, a second port, and a binding chamber intermediate and in fluid communication with the first port and the second port. The binding chamber comprises an unmodified flat glass surface... Agent: Christensen, O'connor, Johnson, Kindness, Pllc

20090215124 - Nucleic acid isolation methods and materials and devices thereof: The present invention relates to methods for purifying nucleic acid from a sample using mild conditions that do not affect the chemical integrity of the nucleic acid. The method comprises contacting the sample with an matrix entrapped chitosan solid phase which is able to bind the nucleic acids at a... Agent: Blank Rome LLP

20090215126 - Nucleic acid-free thermostable enzymes and methods of production thereof: The present invention provides thermostable enzymes, such as DNA polymerases and restriction endonucleases, that are substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising these enzymes which may be used in amplifying or sequencing nucleic acid molecules, including... Agent: Life Technologies Corporation C/o Intellevate

20090215127 - Ph adjustment free system for producing fermentable sugars and alcohol: The present invention relates to a process for producing downstream products, such as fermentable sugars (e.g., glucose) and alcohols (e.g., ethanol) from starch-containing material (e.g., grain) without a pH adjustment before or after the starch liquefaction step.... Agent: Danisco Us Inc. Attention: Legal Department

20090215128 - Methods for degrading lignocellulosic materials: The present invention relates to methods for degrading a lignocellulosic material, comprising: treating the lignocellulosic material with an effective amount of one or more cellulolytic enzymes in the presence of at least one surfactant selected from the group consisting of a secondary alcohol ethoxylate, fatty alcohol ethoxylate, nonylphenol ethoxylate, tridecyl... Agent: Novozymes, Inc.

20090215130 - L-amino acid producing bacterium and method of producing l-amino acid: An L-amino acid is produced by culturing an L-amino acid-producing bacterium which belongs to the Enterobacteriaceae family and which has been modified so that the activity of an iron transporter is increased by enhancing expression of one or more genes of the following genes: tonB gene, fepA gene, and fecA.... Agent: Cermak & Kenealy LLP Acs Llc

20090215129 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family having expression of the leuo gene attenuated: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the leuO gene.... Agent: Cermak & Kenealy LLP Acs Llc

20090215131 - L-glutamic acid producing bacterium and a method for producing l-glutamic acid: The present invention describes an L-glutamic acid-producing bacterium which belongs to the genus Pantoea, Enterobacter, Klebsiella or Erwinia, wherein the bacterium has been modified by gene recombination to inactivate the rpoS gene. A method is also described for culturing the bacterium in a medium to cause accumulation of L-glutamic acid... Agent: Cermak & Kenealy LLP Acs Llc

20090215132 - Novel amide hydrolase gene: The present invention relates to an amide hydrolase which is with excellent thermostability and stereoselectively hydrolyzes an α-amino acid amide; a gene encoding the enzyme protein; a novel recombinant vector containing the gene; a transformant containing the recombinant vector; and a process for producing an L-α-amino acid using the transformant.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20090215133 - Production of l-lysine and l-lysine-containing feed additives: e

20090215134 - Genetically modified microorganism and process for production of macrolide compound using the microorganism: A genetically modified microorganism capable of directly producing a 16-hydroxylated macrolide compound; and a process for producing a 16-hydroxylated macrolide compound using the microorganism. Specifically, a genetically modified microorganisms having DNA encoding a polypeptide involved in the biosynthesis of a macrolide compound pladienolide and DNA encoding a polypeptide having a... Agent: Birch Stewart Kolasch & Birch

20090215135 - Novel gene sts 22: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, Pc

20090215136 - Pseudomonas sp, hn-72 and purification method of 2,6-naphthalene dicarboxylic acid using the same: Provided are a novel microorganism and a method for purifying 2,6-naphthalene dicarboxylic acid with high purity using the microorganism. The microorganism is Pseudomonas sp. Strain HN-72 isolated from soil and has the ability to convert 2-formyl-6-naphthoic acid contained as an impurity in a crude naphthalene dicarboxylic acid, which is an... Agent: Merchant & Gould Pc

20090215137 - Methods for the economical production of biofuel precursor that is also a biofuel from biomass: Methods for producing a biofuel precursor are provided. Also provided are biocatalysts that convert a feedstock to a biofuel precursor.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090215138 - Modified yeast consuming l-arabinose: The present invention relates to a method for producing a L-arabinose utilizing yeast strain for the production of ethanol, whereby a yeast strain is modified by introducing and expressing araA gene (L-arabinose isomerase), araB gene (L-ribulokinase D121-N) and araD gene (L-ribulose-5-P 4-epimerase) and carrying additional mutations in its genome or... Agent: Gauthier & Connors, LLP

20090215139 - Ethanol recovery process and apparatus for biological conversion of syngas components to liquid products: Ethanol and other liquid products produced by the contacting CO and/or a mixture of CO2 and H2 with a microorganism in a bioreactor are separated using a combination of distillation and vapor permeation membranes. The bioreactor passes an effluent with an ethanol concentration of 1 to 6 wt % to... Agent: Cardinal Law Gruop

20090215140 - Novel microalga and process for producing hydrocarbon: The present invention relates to a novel microalga Pseudochoricystis ellipsoidea having the ability to produce hydrocarbons, and to a process for producing hydrocarbons, characterized by culturing a microalga belonging to the genus Pseudochoricystis or the genus Choricystis having the ability to produce hydrocarbons, and collecting the hydrocarbon from the resulting... Agent: Harness, Dickey & Pierce, P.L.C

20090215141 - Biofuel generating system: A biofuel generating method and biofuel generating device comprising operationally linking an anaerobic digester with a hydroponic biomass energy crop production system in a symbiotic relationship. The hydroponic system continually provides high energy containing biomass crops as feed stock to the anaerobic digestor and the anaerobic digestor provides nitrogenous digestate... Agent: Ostrolenk Faber Gerb & Soffen

20090215142 - Horizontal array bioreactor for conversion of syngas components to liquid products: A membrane supported bioreactor arrangement and method for anerobic conversion of gas into liquid products including membrane modules having hollow fibers, each of the hollow fibers formed from an asymmetric membrane wall having a porous outer layer defining biopores for retaining a porous biolayer about the outer surface of the... Agent: Cardinal Law Group

20090215143 - Controlled alteration of pores using fluid flow and fabrication of articles thereby: The invention relates to microscopic structures and methods of making and using the structures. A method of forming a microscopic structure of a material includes obtaining a solution (310) containing the material, establishing a flowing stream of the solution (310) in a capillary (104), wherein the capillary (104) has an... Agent: Fish & Richardson Pc

20090215144 - Immobilisation of bacteria to a geological material: The invention relates to a method for immobilising bacteria in a material permeable to the bacteria, in particular a geological body, comprising forming a first zone comprising the bacteria in the material and allowing the first zone to move through at least part of the material; forming a second zone... Agent: Hoffmann & Baron, LLP

20090215145 - Method for controlling nad(p)/nad(p)h ratio by oxidoreductase: Provided is a method capable of effectively treating various diseases associated with energy excess, such as obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, via elevation of an NAD(P)+/NAD(P)H ratio by increasing an NAD(P)+ concentration in vivo or in vitro through use of NAD(P)H as a substrate or... Agent: Birch Stewart Kolasch & Birch

20090215148 - Conjugates of biological substances: Chemically reactive carbocyanine dyes that are intramolecularly crosslinked between the 1-position and the 3-position, their bioconjugates and their uses are described. 1,3′-crosslinked carbocyanines are superior to those of conjugates of spectrally similar 1,1′-crosslinked or non-crosslinked dyes. The invention includes derivate compounds having one or more benzo nitrogens.... Agent: Jeffrey A. Mckinney, J.d., Ph.d.

20090215146 - Method for producing virus-type particles containing an active substance: The invention relates to a method for producing virus-type particles containing an active substance. Proteins, which comprise a first amino acid sequence which is derived from a first virus protein, and fusion proteins are assembled in order to form the virus-type particles. The proteins and the fusion proteins are coexpressed... Agent: Fish & Richardson P.c.

20090215147 - Use of mutant herpes simplex virus-2 for cancer therapy: The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 has fusogenic activity, and comprises a modified/mutated ICP10 polynucleotide encoding a polypeptide having ribonucleotide reductase activity and lacking protein kinase... Agent: Townsend And Townsend And Crew, LLP

20090215149 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20090215150 - Sample container and filtration apparatus and method of filtration using the same: A sample container and filtration apparatus is described comprising a sealable sample container and a surface that is configured to interface with a vacuum base. When the surface interfaces with the vacuum base, a portion of the sample container is broached, providing a pathway for the vacuum source to pull... Agent: Cantor Colburn, LLP

20090215151 - Two-step immunization procedure against chlamydia infection: A host is immunized against infection by a strain of Chlamydia by initial administration of an attenuated bacteria harbouring a nucleic acid encoding a Chlamydia protein followed by administration of a Chlamydia protein in ISCOMs. This procedure enables a high level of protection to be achieved.... Agent: Sim & Mcburney

20090215154 - Method of preparing micro-and nanometric particles with labile products: The invention relates to a method of obtaining micro- and nanometric polymeric particles in a controlled, reproducible manner. The aforementioned particles have a spherical shape and a very narrow, uniform size distribution. The invention comprises the use of an easy particle-forming method consisting in using hydrodynamic forces to focus a... Agent: Ladas & Parry LLP

20090215152 - Acetoin high-yield bacillus pumilus strain: A high-yield bacterial strain for producing acetoin named Bacillus pumilus XH195 has been deposited in a microorganism deposit center in Germany. The deposit number is DSM 16187. The bacteria of the strain are rod-shaped, 1.5 μm to 3.0 μm in length, and 0.6 μm to 0.7 μm in diameter. The... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090215153 - Stacked array bioreactor for conversion of syngas components to liquid products: A membrane supported bioreactor arrangement and method for anaerobic conversion of gas into liquid products including membrane modules having hollow fibers packed across a cross sectional area of the membrane module, each of the hollow fibers formed from an asymmetric membrane wall having a porous outer layer defining biopores for... Agent: Cardinal Law Group

20090215155 - Algae producing trough system: A trough lining assembly is placed in a series of troughs at a biomass processing facility. The trough lining assembly includes a waterproof liner that lies against the sides of a trough, an aerator, and a retention mechanism that retains the aerator at the bottom of the trough. The aerator... Agent: Etherton Law Group, Llc

20090215156 - Method for fabricating nanogap and nanogap sensor: The present invention relates to a method of fabricating a nanogap and a nanogap sensor, and to a nanogap and a nanogap sensor fabricated using the method. The present invention relates to a method of fabricating a nanogap and a nanogap sensor, which can be realized by an anisotropic etching... Agent: Casimir Jones, S.c.

20090215159 - Device for handling and analysis of a biological sample: An apparatus for detection of an analyte of interest in a solid, semi-solid, or liquid biological sample, using a lateral flow assay test strip, is described. The apparatus minimizes sample handling and manipulation upon introduction of the sample into a sample-receiving chamber and transfer of the sample to a test... Agent: King & Spalding LLP

20090215157 - Methods for pathogen detection: The present disclosure relates to methods, systems, devices, and microfluidic chips that may be used for the detection of pathogens.... Agent: Searete Llc Clarence T. Tegreene

20090215158 - Micro flow channel chip: A micro flow channel chip of the present invention has multiple grooves formed on a substrate to be connected with each other in parallel or in series and capillaries, chemically-modified in a manner different from each other, laid in the multiple grooves, wherein detected data can be obtained by supplying... Agent: Rabin & Berdo, Pc

20090215160 - Endoscope washing and disinfecting evaluation apparatus: A connection base portion of a stripping solution unit storing a stripping solution is connected to an insertion opening of a channel in an insertion portion of an endoscope. A distal end portion of the insertion portion formed with a distal end opening of the channel is attached, with a... Agent: Scully Scott Murphy & Presser, Pc

20090215161 - Microorganism testing device and chip for testing microorganisms: There is disclosed a microorganism testing device in which various types of microorganisms can be easily concentrated. The microorganism testing device includes a detection chip, a carrier device, a controller, and a magnet. The detection chip includes a specimen container for holding a specimen containing microorganisms, a trapping particle liquid... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090215162 - Nucleic acid amplification device: This invention provides a nucleic acid amplification device whereby the abundance of a target molecule can be maintained before and after a step of separately amplifying a sample such that highly accurate analysis results that can be applied to gene expression analysis can be obtained. Also, a nucleic acid amplification... Agent: Stanley P. Fisher Reed Smith LLP

20090215163 - Syngas conversion system using asymmetric membrane and anaerobic microorganism: A stable system for producing liquid products such as ethanol, butanol and other chemicals from syngas components contacts CO or a mixture of CO2 and H2 with a highly porous side of an asymmetric membrane under anaerobic conditions and transferring these components into contact with microorganisms contained within bio-pores of... Agent: Cardinal Law Group

20090215167 - Cationic graft-copolymer for non-viral gene delivery vector: s

20090215166 - Cationic polymer for transporting nucleic acids in cells: The invention relates to a cationic polymer containing cationic oligomers cross-linkable by fissile linker sequences, wherein said cationic polymers form, together with nucleic acids, polyplexes and can be used for cell transfection and the invention is characterised in that the cationic polymer contains intracellular reductive or enzymatic fissile linker sequences.... Agent: Bowditch & Dewey, LLP

20090215165 - High-level expression of recombinant antibody in a mammalian host cell: A mammalian host cell with a high-level expression of recombinant antibody containing a double-gene vector with gene optimized nucleotide sequences encoding the light and the heavy antibody chains. The double-gene vector itself. A process for enhancing the production of recombinant antibody in a mammalian host cell.... Agent: Fisher, Christen & Sabol

20090215164 - Recombinant gene of adenovirus vector and p53 gene for treating proliferative diseases: The invention relates to the application of a recombinant of adenovirus vector and human tumor suppressor p53 gene expression cassette for producing the medicine for treating proliferative disease. In particular the invention relates to the application of a recombinant of adenovirus vector and human tumor suppressor p53 gene expression cassette... Agent: Ladas & Parry LLP

20090215168 - Transcriptional control in alicyclobacillus acidocaldarius and associated genes, proteins, and methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of modulating transcription or transcription or transcriptional control using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.... Agent: Traskbritt / Battelle Energy Alliance, Llc

20090215169 - Method for regulating protein function in cells using synthetic small molecules: Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from FKBP and DHFR proteins are fused to a protein of interest and the presence or absence of the ligand is used to modulate the stability of the... Agent: King & Spalding LLP

20090215170 - Plexin family-like polypeptide, dna encoding the same and uses thereof: The present invention is directed to a novel plexin family like DNA, a gene containing the DNA, novel polypeptide encoded by the DNA, a recombinant protein containing the polypeptide or heterologous polypeptide sequences, antibodies which bind to the polypeptides, methods for producing the polypeptides of the present invention. Conditions that... Agent: Birch Stewart Kolasch & Birch

20090215171 - Pelcam-1-related molecules compositions kit of parts and associated methods of use: An isolated polynucleotide coding for platelet endothelial cell adhesion molecule-1 (PECAM-1), and obtainable by amplifying cDNA from total human white blood cells by PCR; peptides encoding PECAM-1 5th Ig-like domain; an antibody against one of the peptides; associated compositions methods and kits of parts.... Agent: Edwards Angell Palmer & Dodge LLP

20090215172 - Methods and compositions related to cyclic peptide synthesis: Disclosed are compositions and methods for cyclization of polymers such as peptides.... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20090215174 - Methods of inhibiting umami taste receptors: Methods of inhibiting umami taste receptors are provided. These methods comprise contacting T1R1/T1R3 umami taste receptors with a sweet-taste inhibitor that also inhibits both the T1R1/T1R3 umami taste receptor and the T1R2/T1R3 sweet taste receptor.... Agent: Hunton & Williams LLP Intellectual Property Department

20090215173 - Pkd ligands and polynucleotides encoding pkd ligands: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate protein kinase D (PKD) activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to cellular localization signals,... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090215175 - Modulation of the poliovirus receptor function: The present invention relates to the identification, the isolation and the use of molecules interfering with the function (s) mediated by the poliovirus receptor (PVR) on cells. The molecules can be used for the treatment of cells having a metastatic potential, metastasis and cancer. Further methods are provided that are... Agent: David S. Resnick

20090215176 - Differential pressure pump system: The present disclosure is directed to a fluid pumping mechanism that uses differential pressure to drive flow through one or more culture chambers. Fluid contained within a first chamber can be caused to flow through one or more culture chambers and thence to a second chamber upon establishment of a... Agent: Dority & Manning, P.a.

20090215177 - Methods, surface modified plates and compositions for cell attachment, cultivation and detachment: The present invention relates to the field of mammalian cell culture, and provides methods and compositions for cell attachment to, cultivation on and detachment from a solid substrate surface containing from at least about 0.5% N, a sum of O and N of greater than or equal to 17.2% and... Agent: Philip S. Johnson Johnson & Johnson

20090215178 - Methods to enhance the stability and homogeneity of transgene expression in clonal cell lines: Strategies for increasing the productivity of recombinant protein expression in isogenic cell-lines. Development of a novel selection system for the improved stability and homogeneity of transgene expression in isogenic cells without the dependence on continuous selective drugs.... Agent: Zequn Tang

20090215179 - Transgenically preventing establishment and spread of transgenic algae in natural ecosystems: Genetic mechanisms for mitigating the effects of introgression of a genetically engineered genetic trait of cultivated algae or cyanobacteria to its wild type or to an undesirable, interbreeding related species. as well as preventing the establishment of the transgenic algae or cyanobacteria in natural ecosystems.... Agent: Dodds & Associates

  
08/20/2009 > patent applications in patent subcategories. inventions list

20090208918 - Methods and devices for ex-vivo maintenance of bone marrow, hematopoiesis and blood cell production: Devices and methods are provided for the ex vivo maintenance of bone marrow ‘niches’ or normal physiologic home of bone marrow (BM). Intact bone marrow is perfused with a medium that supports cell viability. Stem and progenitor cells may be maintained, expanded or differentiated within the system, screened for responses... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090208920 - Assay device and method: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein:... Agent: Morrison & Foerster LLP

20090208919 - Particle matrix for storage of biomolecules: Matrices for manipulation of biopolymers, including the separation, purification, immobilization and archival storage of biopolymers is disclosed.... Agent: Rosenbaum & Associates, P.C.

20090208922 - Fet based sensor for detecting biomolecule, method for preparing the same, and method for detecting biomolecule using the fet based sensor: Provided is a SWNT-FET-based sensor for detection of biomolecules including an increased Schottky contact area, a method for preparing the same, and a method for detection of biomolecules using the SWNT-FET-based sensor. According to the method of the present invention, a SWNT-FET-based sensor for detection of biomolecules having a thin... Agent: Haynes Beffel & Wolfeld LLP

20090208921 - Methods of detection of cancer using peptide profiles: The disclosed methods address the identification and monitoring of cancer in a subject using serum peptide profiles. Such profiles allow the detection of the differential presence of certain serum peptide markers in comparison with controls. The profiles can be determined employing mass spectrometry.... Agent: Edwards Angell Palmer & Dodge LLP

20090208923 - System and method for diagnosing diseases: One aspect of the invention provides a method of diagnosing a disease condition, comprising measuring presence or amount of a targeted protein or a degradation product of said protein in a collected biological sample as a marker for the disease condition. The targeted protein or degradation product is selected for... Agent: David W. Highet, Esq. Becton Dickinson And Company

20090208926 - Diagnosis of liver pathology through assessment of protein glycosylation: Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease... Agent: Woodcock Washburn LLP

20090208924 - Generation of replication competent viruses for therapeutic use: The present invention relates to the generation or replication-competent viruses having therapeutic utility. The replication-competent viruses of the invention can express proteins useful in the treatment of disease.... Agent: Banner & Witcoff, Ltd.

20090208925 - Methods and compositions for determining hypersusceptibility of hiv-1 to non-nucleoside reverse transcriptase inhibitors: This invention relates to methods for determining hypersusceptibility of HIV-1 viruses to non-nucleoside reverse transcriptase inhibitors (NNRTIs) based on the viral genotypes. The methods generally comprise detecting, in a gene encoding reverse transcriptase of the HIV-1, the presence of a mutation at codon 65, 69, or 74 alone or in... Agent: Jones Day

20090208957 - Alternate labeling strategies for single molecule sequencing: Systems and methods of enhancing fluorescent labeling strategies as well as systems and methods of using non-fluorescent and/or non-optic labeling strategies, e.g., as with single molecule sequencing using ZMWs, are described.... Agent: Quine Intellectual Property Law Group, P.C.

20090208944 - Assessing outcomes for breast cancer patients treated with tamoxifen: This document provides methods and materials related to assessing the likely outcome for mammals (e.g., humans) with cancer (e.g., breast cancer). For example, methods and materials that involve assessing a breast cancer patient's cytochrome P450, family 2, subfamily D, polypeptide 6 (CYP2D6) genotype to determine the likelihood of the beast... Agent: Fish & Richardson P.C.

20090208965 - Automated method for detecting cancers and high grade hyperplasias: Automated methods for detecting cancer and related hyperplasias in biological samples.... Agent: Kelley Drye & Warren LLP

20090208968 - Compositions and methods for detection of hepatitis a virus nucleic acid: Nucleic acid oligomeric sequences and in vitro nucleic acid amplification and detection methods for detecting the presence of HAV RNA sequences in samples are disclosed. Kits comprising nucleic acid oligomers for amplifying and detecting HAV nucleic acid sequences are disclosed.... Agent: Gen Probe Incorporated

20090208961 - Compositions and methods for use in analytical reactions: Compositions, methods, substrates and systems for use in analysis of single molecule reactions and particularly single molecule nucleic acid sequence analysis. Compositions that include non-reactive, distinguishable or undetectable competitive substrates for the reaction system of interest are provided, as well as their use in systems and substrates for such applications,... Agent: Pacific Biosciences Of California, Inc.

20090208951 - Detection of t-dna: The present invention relates to a method for the detection of transgenic DNA (tDNA) in a living being and to a kit for performing such a method.... Agent: Klarquist Sparkman, LLP

20090208948 - Detection of toxigenic strains of clostridium difficile: Primers and probes for detection of toxin-producing (toxigenic) strains of Clostridium difficile, and to methods of detecting toxigenic strains using these primers and probes. Toxigenic strains of C. difficile are detected by nucleic acid-based amplification methods using particular primers and probes that bind to the toxin B (TcdB) gene. These... Agent: Knobbe Martens Olson & Bear LLP

20090208930 - Dna decontamination method: The invention is related to a method for amplifying a methylated target nucleic acid in a sample while avoiding amplification of a non-methylated target nucleic acid by inactivating it. This is accomplished by a restriction enzyme digest after bisulfite treatment of the target nucleic acid. The invention is further related... Agent: Roche Molecular Systems, Inc. Patent Law Department

20090208959 - Fluorescence-labeled oligonucleotide to detect nucleic acid and method for acquiring information about double-strand formation by using fluorescence-labeled oligonucleotide to detect nucleic acid: A fluorescence-labeled oligonucleotide to detect nucleic acid has a base sequence complementary to the nucleic acid chain to be detected and changes in fluorescence characteristics upon double-strand formation with the nucleic acid chain to be detected. The label is an intercalating fluorescent dye and a non-intercalating fluorescent dye. The intercalating... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090208931 - Gene expression level normalization method, program and system: It is an object to improve the reliability and accuracy of normalization of gene expression levels, which have been measured separately, by providing a method for the acquisition of an index of high reliability and high accuracy as an index for performing the normalization such that the gene expression levels... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090208963 - Gene involved in v(d)j recombination and/or dna repair: The invention relates to a new gene and protein involved in V(D)J recombination and repair. The invention also relates to methods of diagnosis and therapy using these genes and protein. The invention also relates to transgenic animals over- and under-expressing said gene.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20090208967 - Genetic polymorphisms as predictive diagnostics for adverse drug reactions (adr) and drug efficacy: The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad... Agent: Siemens Corporation Intellectual Property Department

20090208939 - Identification of molecular diagnostic markers for endometriosis in blood lymphocytes: The invention comprises a method of identifying or predicting the predisposition to endometriosis in a female subject comprising determining the level of gene expression of at least one differentially-expressed gene or protein or peptide of peripheral blood leukocytes in a sample of peripheral blood leukocytes or peripheral blood in a... Agent: Knobbe, Martens, Olson & Bear, LLP

20090208936 - Identification of molecular interactions and therapeutic uses thereof: We report the real-time monitoring of protein-protein interactions without labeling either of the two interacting proteins, posing minimum effects on the binding properties of the proteins. In particular, the methods provide protein/aptamer complexes to probe the interactions in a competitive assay where the binding of an aptamer to its target... Agent: Akerman Senterfitt

20090208962 - Markers for breast cancer: Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.... Agent: Goodwin Procter LLP Attn: Patent Administrator

20090208942 - Method and apparatus for correlating levels of biomarker products with disease: In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual by providing data corresponding to a level of products of selected biomarkers and applying the data to... Agent: Fish & Richardson P.C.

20090208928 - Method and device for the in vitro detection of polycystic ovarian syndrome (pcos) and pathologies involving cardiovascular risk: The invention relates to a method and device for the in vitro detection of polycystic ovary syndrome (PCOS) and pathologies involving cardiovascular risk. An in vitro assay method and assay device (kit) for the diagnosis of the presence or the predisposition to suffer from PCOS and/or cardiovascular risk factors including:... Agent: Ladas & Parry LLP

20090208940 - Method for detecting c. albicans: A HWP1 gene sequence or fragment or variants thereof as a target region in a nucleic acid based assay for Candida albicans and an isolated nucleic acid molecule useful as a probe for identifying C. albicans in a sample. A method for the detection of C. albicans in a sample... Agent: Jacobson Holman PLLC

20090208933 - Method for diagnosis and/or prognosis of a septic syndrome: H

20090208941 - Method for investigating cytosine methylations in dna: A method for sensitive and specific detection of cytosine methylation is described wherein the DNA to be analyzed is subjected to initial enrichment. More specifically, said enrichment can be effected in a methylation-specific, sequence-specific or origin-specific fashion. Thereafter, the enriched DNA is converted in a methylation-specific fashion. The converted DNA... Agent: Kriegsman & Kriegsman

20090208966 - Method for removing a fluid substance from a closed system: A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having... Agent: Gen Probe Incorporated

20090208943 - Method for the high throughput screening of transposon tagging populations and massive parallel sequence identification of insertion sites: Method for the identification of a gene in a transposon population, comprising isolating genomic DNA, optionally pooling the DNA, restrict the DNA in the pools using an enzyme, ligate adaptors, amplifying the adaptor-ligated fragments with primers, one of which is a primer complementary to a border of a transposon sequence,... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090208945 - Method for the prediction of adverse drug responses to stains: The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy. Still further the invention provides polymorphic sequences and other genes. The present invention further relates to isolated... Agent: Siemens Corporation Intellectual Property Department

20090208929 - Method of in-vitro detection and quantification of hiv dna by quantitative pcr: Process for the detection and quantification in-vitro of HIV DNA by quantitative PCR. The invention consists of developing pairs of oligonucleotides capable of hybridizing with fragments of the gag gene sequence present in the genome of the HIV virus. These oligonucleotides permit amplification of the viral DNA by quantitative PCR.... Agent: Ladas & Parry LLP

20090208958 - Methods and kits for detecting single nucleotide polymorphisms of chromosome implicated in premature canities: Methods and kits for diagnosing a predisposition to premature canities in an individual are disclosed. A method for diagnosing a predisposition to premature canities in an individual comprises detecting at least one SNP marker of the human chromosome 9, selected from the group consisting of rs306534, rs3739902, rs575916, and rs365297.... Agent: Buchanan, Ingersoll & Rooney PC

20090208955 - Methods for identifying sequence motifs, and applications thereof: The present invention relates to methods and algorithms that can be used to identify sequence motifs that are either under- or over-represented in a given nucleotide sequence as compared to the frequency of those sequences that would be expected to occur by chance, or that are either under- or over-represented... Agent: Wilmerhale/new York

20090208960 - Methods for identifyng cellular modulators of disaggregation activity or aggregation activity in an animal: Methods for identifying a cellular modulator of a biological disaggregation activity or a biological aggregation activity of an animal are provided. Methods for identifying a compound which modulates biological disaggregation activity or a biological aggregation activity in a biological sample are provided.... Agent: Fenwick & West LLP

20090208932 - Methods of detecting an analyte in a sample: The invention relates to methods for detecting an analyte in a sample. The methods rely on the activity of polymerases upon polynucleotide substrates which are linked to a molecule, for example an antibody, which binds the analyte. Activity of the polymerases can be detected by the incorporation of suitably labelled... Agent: Bozicevic, Field & Francis LLP

20090208927 - Methods of detecting sequence-specific dna binding proteins: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding... Agent: Proskauer Rose LLP

20090208950 - Methods of identifying an organism from a heterogeneous sample: This disclosure features methods of identifying at least one organism from a heterogeneous sample. The methods include: (a) obtaining a nucleic acid from at least one organism in a heterogeneous sample; (b) imaging said nucleic acid; (c) obtaining a restriction map of said nucleic acid; and (d) correlating the restriction... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090208953 - Neurofibromin pathway modulators: The present invention encompasses methods for treating neurofibromatosis and methods for screening for modulators of the neurofibromin pathway.... Agent: Polsinelli Shughart PC

20090208934 - Pecam-1 genotype: The invention relates to methods of identifying inter-patient differences in genotype of PECAM-1 to diagnose and assess risk of arterial disease. It further relates to methods of identifying therapeutics agents for to treat coronary arterial disease, and to methods for determining and exploiting such differences to improve medical outcomes.... Agent: Edwards Angell Palmer & Dodge LLP

20090208949 - Phosphatidylinositol phosphate kinase type i gamma splice variants as biomarkers and drug targets for epithelial cancers: The present invention relates generally to the field of phosphatidylinositol based signaling pathways, and more specifically to the use of novel members of these pathways for disease prognosis and treatment. In some aspects, the present invention relates to the use of novel splice variants of type I phosphatidylinositol phosphate kinase... Agent: Wisconsin Alumni Research Foundation (warf)

20090208969 - Polynucleotides and polypeptides encoding receptors: Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20090208954 - Primer set for amplification of ugt1a1 gene, reagent for amplification of ugt1a1 gene containing the same, and the uses thereof: Primer sets for amplifying target regions containing sites to be detected in the UGT1A1 gene by a gene amplification method are provided, wherein the primer sets can amplify the regions specifically. Three pairs of primer sets are used including forward primers consisting of the base sequences of SEQ ID NOs:... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090208956 - Primer set for amplifying cyp2c9 gene, reagent for amplifying cyp2c9 gene containing the same, and the uses thereof: A primer set for amplifying a region including a site to be detected of CT2C9*3 in the C-YT2C9 gene by a gene amplification method is provided, wherein the primer set can amplify the region specifically. A pair of primer set is used including a forward primer consisting of the base... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090208947 - Primers, methods and kits for amplifying or detecting human leukocyte antigen alleles: The present invention describes primers, methods and kits for amplifying and identifying HLA alleles. Using these primers, all HLA alleles at a single locus can be amplified using either a multiplex or non-multiplex PCR approach. Within sets of the primers, control primer pairs may be used to produce control amplicons... Agent: Life Technologies Corporation C/o Intellevate

20090208946 - Rationale, methods, and assays for identifying human and non-human primate taste specific genes and use thereof in taste modulator and therapeutic screening assays: This invention relates to novel rationale and methods for identifying human and primate taste-specific genes, including genes involved in salty taste perception, especially human salty taste perception, but also genes involved in sweet, bitter, umami, and sour taste perception, and genes involved in other taste cell or taste receptor related... Agent: Hunton & Williams LLP Intellectual Property Department

20090208935 - Reagents and methods for identifying and modulating expression of tumor senescence genes: This invention identifies tumor senescence genes induced by treatment with cytotoxic agents. The invention provides reagents and methods for identifying compounds that induce expression of these cellular genes and produce cellular senescence, particularly senescence in tumor cells. The invention also provides reagents that are recombinant mammalian cells containing recombinant expression... Agent: Keown & Zucchero, LLP

20090208937 - Recurrent gene fusions in prostate cancer: Recurrent gene fusions in prostate cancer of androgen regulated genes or housekeeping genes and ETS family member genes are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.... Agent: Casimir Jones, S.c.

20090208964 - Soybean polymorphisms and methods of genotyping: Polymorphic soybean DNA loci are useful for genotyping between at least two varieties of soybean. Sequences of the loci are useful for designing primers and probe oligonucleotides for detecting polymorphisms in soybean DNA. Polymorphisms are useful for genotyping applications in soybean. The polymorphic markers are useful to establish marker/trait associations,... Agent: Thompson Coburn, LLP

20090208938 - Use of the mcm8 gene for the preparation of a pharmaceutical composition: The use of the human or animal MCM8 gene coding for a DNA helicase, or parts of the gene, or transcripts thereof, or antisense nucleic acids able to hybridize with part of the transcripts, or silencing RNA derived from parts of the transcripts and able to repress the MCM8 gene,... Agent: Young & Thompson

20090208952 - Utility of ret mutant in diagnosis and treatment of melanoma: The invention relates to a method of detecting a RET mutant in a melanoma cell. Also disclosed is a method of modulating the activity of a RET mutant in a melanoma cell with an agent that interferes with the activity of the RET mutant.... Agent: Hogan & Hartson L.L.P.

20090208972 - Cytotoxic protein and utlization thereof: This invention provides a cytotoxic protein (M toxin) produced by Helicobacter pylori, a partial peptide, and an antitumor agent containing the cytotoxic protein. The protein is obtained by culturing a transformant which is transformed with a recombination vector containing DNA coding the cytotoxin protein. This invention provides further the use... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090208974 - Human neuronal attachment factor-1: A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20090208971 - Insulin promoter factor 1 as target/marker of beta cell failure: The present invention relates to the monitoring of disease progression and diagnosis of beta-cell failure in diabetes by measuring levels of IPF-1 in a liquid sample, and to screening for novel compounds for the prevention and/or treatment of diabetes.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20090208973 - Methods to identify compounds useful for the treatment of proliferative and differentiative disorders: The present invention relates to the discovery, identification and characterization of nucleotides that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18, FBP19,... Agent: Jones Day

20090208970 - Probe for detection and quantification of inositol-1,4,5-trisphosphate and a method for detecting and quantifying inositol-1,4,5-trisphosphate using the same: A probe for detection and quantification with high accuracy in a noninvasive manner as to where and when inositol-1,4,5-trisphosphate is generated in living cells, and a method for detecting and quantifying inositol-1,4,5-trisphosphate using the probe.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090208975 - Device and methods for detecting a target cell: The present invention relates to devices for detecting intact target cells in a sample comprising a detection zone comprising an immobilized specific binding reagent, capable of forming a complex with a target analyte on a target cell. Once labeled, detection of the label indicates the absence, presence and/or amount of... Agent: Beckman Coulter, Inc. Mitchell E. Alter

20090208977 - Materials and methods for sperm sex selection: Materials and Methods for the separation of X- and Y-chromosome bearing sperm, for example in a semen sample, are provided. The methods involve contacting the semen sample with a binding agent, such as an antibody, that specifically binds to an antigen that is specific for an X- or Y-chromosome. Kits... Agent: Speckman Law Group PLLC

20090208979 - Method for identifying antipsychotic drug candidates: The present invention provides a method for identifying a compound or a combination of compounds having a pharmacological behavior that qualifies it as a candidate for clinical development of a drug for treatment of a psychiatric disease or disorder, preferably schizophrenia. According to this method, a candidate drug is assessed... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090208978 - Panel cell used for granulocyte antibody detection: A panel cell for detecting anti-HNA antibody is disclosed. The panel cell is obtained by introducing a DNA coding for an HNA antigen corresponding to the anti-HNA antibody into a cell so as to enable the expression of the DNA under the condition for use in the detection procedure, wherein... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090208976 - Regulation of f1-atpase beta subunit cellular location: It has been discovered that the ability of analogues to affect binding of a labeled β-casomorphin (an enterostatin antagonist) to recombinant rat F1-ATPase β-subunit was closely correlated with their enterostatin-like biological activity. Using immunohistochemistry and western blots, the presence of the F1-ATPase β-subunit was demonstrated in plasma membranes of liver,... Agent: Patent Department Taylor, Porter, Brooks & Phillips, L.l.p

20090208980 - Method of identifying cancer biomarkers and cancer progression: An efficient method for identifying important cancer biomarkers and identifying progression of bladder cancer using pro-u-PA as a clinical tool is provided. Searching for biomarkers critical for bladder carcinoma diagnosis and prognosis, secreted proteomes of highly malignant U1 and pre-malignant U4 cell lines are first analyzed. Proteins in the cultured... Agent: Sinorica, LLC

20090208981 - Method for analysis of interaction between small molecules and cells and apparatus thereof: A method and an apparatus are provided for analyzing the interaction between small molecules and cells without using density gradient and antibody but using a column packed with identical resin particles. The interactions between cell surface and resin particles resulting in the different retention time of cells treating by different... Agent: Hung-chih Tseng Hdls Ipr Services

20090208982 - Assay method for human orotate phosphoribosyltransferase protein: The method for assaying human orotate phosphoribosyltransferase protein includes employing, in combination, an anti-human orotate phosphoribosyltransferase antibody which recognizes an epitope present in a region of 86th to 108th amino acid residues from the N-terminus of human orotate phosphoribosyltransferase, and an anti-human orotate phosphoribosyltransferase antibody which recognizes an epitope present... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090208984 - Detection of food specific human igg4 antibodies: This invention particularly discloses an improved immunoassay method for the sensitive and specific detection of food specific human IgG4 antibodies. A sample diluent comprising a chaotrophic agent is used to reduce the occurrence of nonspecific antibody-dietary antigen interactions. To reduce competition between IgE and IgG4 antibodies for specific epitopes on... Agent: Attn: E.j. Asbury Iii Taylor Busch, LLP

20090208983 - Diagnose device for measuring the ratio of proteins with similar structure: The present invention relates to a diagnostic device for measuring the ratio of similar structural proteins among the proteins secreted in a liquid test sample taken from diagnosis subject. In further detail, the test device according to the present invention comprises detection marker-antibody conjugate recognizing the same site on two... Agent: Ipla P.A.

20090208987 - Method and composition for stabilizing liquid reagents: The invention relates to methods and compositions for removing a dissociated species from a fluid medium solution during and after it has detached from a solid-phase immersed in said medium, thereby allowing the concentration of free species to remain close to zero, and for improving the signal to noise ratio... Agent: Siemens Corporation Intellectual Property Department

20090208986 - Method and kit for diagnosing acute myocardial infarction: Disclosed herein are method and kit for diagnosing acute myocardial infarction which is capable of predicting and diagnosing whether coronary artery disease is proceed to myocardial infarction or not by using an increase in triglyceride level in high density lipoprotein (HDL) or low density lipoprotein (LDL), a decrease in cholesterol... Agent: The Nath Law Group

20090208985 - Method of evaluating degree of skin sensitivity using squamous cell carcinoma antigen as an indicator thereof: The present invention provides a method for evaluating the degree of skin sensitivity by using the expression of squamous cell carcinoma antigen (SCCA) in skin corneocytes as an indicator thereof.... Agent: Foley And Lardner LLP Suite 500

20090208988 - Protocol and apparatus for determining heparin-induced thrombocytopenia: A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit determination of heparin-induced thrombocytopenia II complex (HiT II).... Agent: Anthony G Sitko PLC

20090208989 - Fluorescence spectropscopy in absorbing media: The invention relates to processes and devices for detecting an analyte in a sample by fluorescence measurement.... Agent: Baker & Daniels LLP / Roche

20090208990 - Human protein acyl transferases and methods of uses therefor: The present invention provides the identification of human Ras palmitoyl acyl transfersase complexes, and nucleic acids coding therefor. In addition, methods of screening for modulators of human Ras palmitoyl acyl transfersase, including high throughput yeast screens, are also provided.... Agent: Polsinelli Shughart PC

20090208991 - Prediction of bone marrow toxicity: The likelihood that a compound will exhibit bone marrow toxicity in an in vivo assay predicted by the ability of the compound to inhibit at least eight kinases from a selected group.... Agent: Grant D. Green, Patent Law Department M/s A2-250, Roche Palo Alto LLC

20090208992 - Paraoxonase 1 enzymatic activity, a risk indicator for major adverse cardiovascular events: Provided herein are methods for assessing the risk a subject or patient without significant evidence of cardiovascular disease has of experiencing a major adverse cardiac event or requiring revascularization near term. Also provided are methods of determining whether a subject who has experienced a major adverse cardiac event is at... Agent: Calfee Halter & Griswold, LLP

20090208993 - Peptide substrates recognisable by a botulinum toxin a, bont/a and the use thereof: The present invention relates to a peptide substrate selectively recognized by botulinum toxin type A, BoNT/A, comprising a Nop-(Z)-Pya fragment in the peptide structure thereof, wherein Z represents an amino acids chain, preferably RA, said fragment being cleaved by said toxin. Said invention also relates to the substrate use, in... Agent: Young & Thompson

20090208994 - Genetic incorporation of 3-aminotyrosine into reductases: This invention provides reductase proteins that comprise NH2Y unnatural amino acid residues, systems of orthogonal elements for incorporating NH2Y into reductases and methods of using NH2Y amino acid residues in reductases as molecular probes for probing reductases function, structure and activity.... Agent: Quine Intellectual Property Law Group, P.C.

20090208995 - Pro-clotting enzyme, and method for detection of endotoxin or (1-3)-beta-d-glucan using the same: Objects of the present invention are to provide a DNA fragment encoding a limulus-derived pro-clotting enzyme, a virus harboring the DNA fragment, a cell harboring the virus, a method of producing the pro-clotting enzyme by use of the cell, and means for assaying an endotoxin or (1→3)-β-D-glucan employing the enzyme,... Agent: Sughrue Mion, PLLC

20090208996 - Method and kit for detecting microorganisms on a household surface: This invention is directed to a method and kit for detecting microorganisms on a surface. The invention involves contacting a household surface with a cleaning composition comprising hydrogen peroxide and then placing an acoustic device in close proximity to the household surface to determine if the microorganisms are still present.... Agent: The Clorox Company

20090208998 - D/p creatinine marker, method of determining d/p creatinine, and intended use thereof: A method of indirectly determining D/P creatinine for easily judging a peritoneal function is provided that does not require blood sampling or multiple recoveries of dialysis effluent. The method includes preparing a dialysis effluent obtained by peritoneal dialysis, measuring at least one protein marker selected from the group consisting of... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090208997 - Gpr18 as a biomaker for th1 mediated immune response: The present invention provides the use of GPR18 in diseases or disorders mediated by Th1 cell activation.... Agent: Novartis Corporate Intellectual Property

20090208999 - Crystalline amoxicillin trihydrate powder: The invention relates to crystalline amoxicillin trihydrate powder having a bulk density higher than 0.45 g/ml. The invention also relates to a process for preparing crystalline amoxicillin trihydrate powder, said process comprising: crystallizing amoxicillin trihydrate from a solution containing dissolved amoxicillin; separating the crystals from said solution; and drying the... Agent: Nixon & Vanderhye, PC

20090209000 - Genetically programmed expression of proteins: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods... Agent: Quine Intellectual Property Law Group, P.C.

20090209001 - 2-deoxy-d-ribose 5-phosphate aldolases (deras) and uses thereof: e

20090209002 - Compositions and methods relating to cellular targeting: Plasmodesmal resident components are identified, characterized and isolated. Compositions comprising these components are described and methods of use thereof for plasmodesmal flux modulation and targeting are enabled. In a first embodiment, a novel plasmodesmal receptor-like protein, referred to herein as pldp1, reveals signals sufficient for targeting to plasmodesmata via the... Agent: Michael Best & Friedrich LLP

20090209003 - Mutant pcna: The present invention is to construct a DNA replication reaction system which is excellent in versatility and is easily used. An amino acid sequence of a PCNA monomer which is one of factors involved in DNA replication is prepared so that amino acid residues causing mutual charge repulsion constitute a... Agent: Foley And Lardner LLP Suite 500

20090209004 - Human il-1 beta antagonists: The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind mature human IL-1 Beta. These antibodies, or antigen-binding portions thereof, generally exhibit high binding affinities (low kooff values), reduced deamidation compared to the native antibody, and can be used to treat various diseases such as rheumatoid arthritis,... Agent: Eli Lilly & Company

20090209005 - Chimeric dna polymerase: The present invention provides a chimeric thermostable DNA polymerase that includes a region from a Tth DNA polymerase I, a region from a Taq DNA polymerase I and a DNA polymerase domain. The DNA polymerase domain comprises a portion of a DNA polymerase domain from the Tth DNA polymerase I... Agent: Nixon & Vanderhye, PC

20090209006 - Taci-immunoglobulin fusion proteins: Molecules that interfere with the binding of a tumor necrosis factor receptor with its ligand, such as a soluble receptor, have proven usefulness in both basic research and as therapeutics. The present invention provides improved soluble transmembrane activator and calcium modulator and cyclophilin ligand-interactor (TACI) receptors.... Agent: Alston & Bird LLP

20090209007 - Method of expression cloning in a host cell: The invention relates to a promoter DNA sequence highly suited in an improved expression cloning method for isolation of DNA sequences comprising a DNA sequence encoding a protein of interest in a host cell and to the improved expression cloning method wherein use is made of this promoter. The isolated... Agent: Nixon & Vanderhye, PC

20090209008 - Thermus thermophilus nucleic acid polymerases: The invention provides novel nucleic acid polymerases from strains GK24 and RQ-1 of Thermus thermophilus, and nucleic acids encoding those polymerases, as well as methods for using the polymerases and nucleic acids.... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090209009 - Enzyme compositions for the improved enzymatic hydrolysis of cellulose and methods of using same: A process for the enzymatic hydrolysis of cellulose to produce a hydrolysis product comprising glucose from a pretreated lignocellulosic feedstock and enzymes for use in the process are provided. The process comprises hydrolyzing an aqueous slurry of a pretreated lignocellulosic feedstock with cellulase enzymes, one or more than one β-glucosidase... Agent: Fitzpatrick Cella Harper & Scinto

20090209010 - Methods and systems for selective fluorination of organic molecules: A method and system for selectively fluorinating organic molecules on a target site wherein the target site is activated and then fluorinated are shown together with a method and system for identifying a molecule having a biological activity.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20090209011 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with enhanced expression of the fucpikur operon: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to enhance expression of at least one gene of the fucPIKUR operon.... Agent: Cermak & Kenealy LLP Acs LLC

20090209012 - Method for producing l-amino acids: Disclosed is a process for producing the L-form of an amino acid enzymatically from an enantiomeric mixture of the amino acid. The process includes the step of contacting a transformant or a treated product thereof with an enantiomeric mixture of the amino acid. The transformant includes a single host and... Agent: Birch Stewart Kolasch & Birch

20090209013 - Burkholderia rhizoxina micro-organisms, novel endosymbionts of rhizopus sp. and method for producing rhizoxin and/or rhizoxin-derivates using said micro-organisms: The aim of the invention is to produce novel novel micro-organisms that synthesise rhizoxin or derivates of rhizoxin, and to provide a method for producing rhizoxin oder derivates thereof, without the disadvantages of prior art and in a simpler manner with a higher yield. To this end, bacterial symbionts of... Agent: Jordan And Hamburg LLP

20090209015 - Compositions and methods for production of biofuels: Provided is a method for producing C4 to C14 fatty acids. The method entails providing genetically modified cells that express a heterologous animal TE-II and either a heterologous animal wild type FAS or a ΔTE-I-FAS. The TE-II and the heterologous wild-type or ΔTE-I-FAS are expressed as distinct molecules. The cells... Agent: Hodgson Russ LLP The Guaranty Building

20090209014 - Heterotrophic algal high cell density production method and system: A multiphase culturing process for high density heterotrophic microalgal growth uses crude glycerol as the primary carbon source and produces ω-3 fatty acids. The process uses multiphase growth conditions that decouple the phases of increasing cell density and increasing cell size and fatty acid production. The entire process is integrated... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20090209016 - Engineering fungi for the utilisation of l-arabinose: A fungal microorganism can be engineered by means of genetic engineering to utilise L-arabinose. The genes of the L-arabinose pathway, which were unknown, i.e. L-arabinitol 4-dehydrogenase and L-xylulose reductase, were identified. These genes, together with the known genes of the L-arabinose pathway, form a functional pathway. This pathway can be... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090209017 - Electroporation cuvette with spatially variable electric field: An electroporation cuvette is constructed with electroporation electrodes arranged in non-parallel relation to form a gap whose width varies with the location within the cuvette, plus a pair of positioning electrodes that are arranged to cause electrophoretic migration of biological cells within the cuvette according to cell size. Once the... Agent: Townsend And Townsend And Crew, LLP

20090209018 - Catalase decomposition of hydrogen peroxide in surfactants: A process comprising the steps of continuously adding a catalase enzyme to a process stream, wherein the process stream comprises an amine oxide surfactant and hydrogen peroxide; and mixing the process stream and catalase enzyme.... Agent: The Procter & Gamble Company Global Legal Department - Ip

20090209019 - Bioartificial renal tubule: A bioartificial renal tubule is provided that forms an artificial kidney together with a bioartificial glomerulus suitable for continuous hemofiltration. The bioartificial renal tubule includes an artificial membrane having an inner surface coated with renal tubular epithelial cells and a vessel containing the artificial membrane. The cells are prevented by... Agent: The Webb Law Firm, P.C.

20090209020 - Collagenous matrix with improved porosity and tensile strength and preparation method therefore by using mechanical stimulation system: The present invention relates to a method of preparing a collagen matrix with increased porosity and tensile strength by using mechanical stimulation system. More specifically, in the present invention, the cell-populated gel is being cultured under the condition that the physical forces is loaded for causing the matrix to move... Agent: The Nath Law Group

20090209021 - Variant form of urate oxidase and use thereof: The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxidases.... Agent: Kramer Levin Naftalis & Frankel LLP Intellectual Property Department

20090209022 - Crystal structure of ump kinase and uses thereof: The present invention relates crystals of UMP kinase and computer-assisted methods for screening, identifying, and designing inhibitors and allosteric modulators of UMP kinase.... Agent: Astrazeneca R&d Boston

20090209023 - Method for production of acetic acid bacterium-type ceramide: [Means for Solving the Problems] There has been developed a method for increasing the acetic acid bacterium-type ceramide where the content of the acetic acid bacterium-type ceramide in cells of the acetic acid bacterium is able to be made as high as to a level of 10 to 30 fold... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090209024 - Combinatorial dna library for producing modified n-glycans in lower eukaryotes: The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar transporters and mannosidases to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. The invention provides nucleic acid molecules and combinatorial libraries which... Agent: Merck And Co., Inc

20090209025 - High solid thermophilic anaerobic digester: A device for digesting sludge anaerobically, comprising a digesting tank (100) having an upper region (104) and a lower region (105), and a reaction chamber (107) for converting raw sludge into matured sludge, an inlet (112) for introducing sludge (109) into the digesting tank, at least one transfer pipe (120)... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20090209026 - Alpha-amylase variants with altered properties: Disclosed are compositions comprising variants of alpha-amylase that have alpha-amylase activity and that exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they are derived. The compositions generally comprise at least one of an additional enzyme, a detergent, a surfactant, a chelator, an oxidizing agent, an acidulant, an... Agent: Danisco US Inc. Attention: Legal Department

20090209027 - Introduction of microorganisms in bio-assisted heap leaching operations: The invention discloses a method of introducing microorganisms into a heap of material for bio-assisted heap leaching by preparing microorganisms substantially without exopolymers on their external cell walls; adding such microorganisms to the heap; and re-activating the production of exopolymers on the external cells walls of the microorganisms in the... Agent: Darby & Darby P.C.

20090209028 - Sensing chip: There is provided a sensing chip capable of measuring a refractive index by utilizing a long-range surface plasmon polariton, accurately measuring an accumulative refractive index in a wide range, and more easily enabling sealing for measurement. The present invention relates to the sensing chip which has a thin metal film... Agent: Fish & Richardson P.C.

20090209029 - High-density ion transport measurement biochip devices and methods: The present invention includes biochips for the measurement of cellular ion channels and methods of use and manufacture. The biochips of the present invention have enhanced sealing capabilities provided in part by chemically modifying the surface of the biochip surface or substrate or by exposure to an ionized gas. The... Agent: Morrison & Foerster LLP

20090209030 - Thermal cycler: A thermalcycler is constructing with a first thermalcycler body section of a flexible circuit material or a circuit board material. The first thermalcycler body section has a first face. A first cavity portion is formed in the first face. A second thermalcycler body section is constructed of a flexible circuit... Agent: Lawrence Livermore National Security, LLC

20090209031 - Medical device package: A package for a medical device, the package capable of sustaining viable cells, wherein the package includes a first container, which is configured to receive a medical device and to sustain at least one viable cell, and a fluid port in communication with the first container for allowing sterile passage... Agent: Tyco Healthcare Group Lp

20090209032 - Feeding buffers, systems, and methods for in vitro synthesis of biomolecules: Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of... Agent: Life Technologies Corporation C/o Intellevate

20090209033 - Immortalized hepatocyte cell line secreting modified insulin with glucose sensitivity: The present invention provides a cell line which can be substituted for β cells in human mature pancreatic islets and express insulin in a glucose-concentration dependent manner, and enables the easy obtainment of the number of cells which meets the demand. The present invention also provides a therapeutical cell preparation... Agent: Kratz, Quintos & Hanson, LLP

20090209034 - Tumour rejection antigens: Polypeptides comprising an unbroken sequence of amino acids from SEQ. ID. NO. 1 or 2, with an ability to complex with a major histocompatibility complex molecule type HLA-A2, and preferably HLA-A2.1.... Agent: Wolf Greenfield & Sacks, P.C.

20090209035 - Cell or tissue cultivation apparatus and method of cultivation: A cultivation apparatus and a cultivation method of a culture such as a cell or tissue. Provided are an incubator unit for accommodating a culture and a lever that penetrates through the incubator unit and can move in circular arc around a fulcrum as a center, the fulcrum being set... Agent: Connolly Bove Lodge & Hutz LLP

20090209038 - Cell-mediated directed evolution: The present invention relates to systems which harness the molecular biology of a living cell to direct evolution of biological entities of interest. According to the invention, a host cell is engineered to facilitate mutation of a nucleic acid target corresponding to that entity and select for desirable mutants. As... Agent: Baker Botts L.L.P.

20090209039 - Method and apparatus for microfluidic injection: A method and apparatus for producing a jet or droplet of liquid. An injector device may include a reservoir in fluid communication with a nozzle, and a pressure gradient may be produced in the reservoir (e.g., by a piezoelectric element in an initial direction that is transverse to the emission... Agent: Wolf Greenfield & Sacks, P.C.

20090209036 - Method for accelerating somatic mutations and use thereof in proteomics: The invention relates to a method of accelerating the induction of somatic mutations in vitro. The inventive method comprises the expression of at least one cDNA expressing a modified version of the AID gene in the cells to be mutated, in culture conditions and a medium that are suited thereto,... Agent: Larson & Anderson, LLC

20090209037 - Viral core protein-cationic lipid-nucleic acid-delivery complexes: A nucleic acid delivery complex is provided which comprises a condensed polypeptide/nucleic acid complex and a cationic lipid wherein the complex comprises (a) a nucleic acid sequence of interest (NOI); and (b) one or more viral nucleic acid packaging polypeptides, or derivatives thereof, said polypeptides or derivatives thereof being (i)... Agent: Suzannah K. Sundby Smith, Gambrell & Russel, LLP

  
08/13/2009 > patent applications in patent subcategories. inventions list

20090202976 - Amniopunch and uses thereof: A tissue, such as an amniotic or chorionic membrane, harvesting device that integrates a system facilitating subsequent storage of tissue samples. The device cuts a sample of the target tissue and automatically deposits the sample in a storage vessel. A method of collecting and storing a sample from a target... Agent: Sonnenschein Nath & Rosenthal LLP

20090202977 - Decellularization and recellularization of organs and tissues: The invention provides for methods and materials to decellularize a solid organ and to recellularize such a decellularized organ to thereby generate a solid organ.... Agent: Fish & Richardson P.C.

20090202978 - Method and apparatus for freezing of a biological material: e

20090202982 - Blood-viscosity reducing agent: A blood-viscosity reducing agent contains a protein derived from Bacillus subtilis natto and including, sequentially from an amino group terminal, a first structural amino acid sequence having alanine, threonine, aspartic acid, glycine, valine, glutamic acid, tryptophan, asparagine, valine, aspartic acid, glutamine, isoleucine, aspartic acid, alanine, proline, lysine, alanine, tryptophan, alanine,... Agent: Blakely Sokoloff Taylor & Zafman LLP

20090202980 - Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with: The invention relates to the field of biochemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-β structures and the biological role of these cross-β structures.... Agent: Traskbritt, P.C.

20090202979 - Production of antibody formats and immunological applications of said formats: The invention concerns an in-vitro method for introducing a targeted genome modification into an oocyte or an egg and a method for performing a random insertion in the genome of a host cell.... Agent: Harness, Dickey & Pierce, P.L.C

20090202981 - Triple spin, double pool and revolumization process for concentrating platelets and derivative platelet concentrate: The present invention comprises an improved method of manufacturing platelet concentrate comprising the steps of: performing a first centrifugation of anticoagulated blood, pooling a first platelet rich sample, performing a second centrifugation on the first platelet rich sample whereby the volume of the first platelet rich sample placed in each... Agent: Laurence C. Bonar

20090202985 - Method and apparatus for detecting an electric field fluctuation associated with the permeabilization of a bacterial cell wall: A sensor for detecting an electric field fluctuation associated with the permeabilization of a bacterial cell wall comprises a substrate, at least two electrodes integrated on the substrate, an amplifier integrated on the substrate, and a processor electrically connected to the amplifier to analyze the amplified signal. The substrate and... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20090202983 - Method for determining the concentration of virus particles/virus antigens: The invention provides a method for determining the concentration of virus particles and/or virus antigens in a sample. In particular, the invention relates to determining the concentration of influenza virus particles/influenza virus antigens in a sample. The invention further relates to the use of an ion-exchange matrix for the determination... Agent: Novartis Vaccines And Diagnostics Inc.

20090202984 - Single molecule nucleic acid sequence analysis processes and compositions: Improved solid supports and methods for analyzing target nucleotide sequences are provided herein. Certain improvements are directed to efficiently preparing nucleic acids that comprise nucleotide sequences identical to or substantially identical to one or more target nucleotide sequences, or complement thereof. The prepared nucleic acids include a reference sequence that... Agent: Grant Anderson LLP C/o Portfolioip

20090202999 - method for dna breakpoint analysis: The present invention relates to a method for identifying a DNA breakpoint and agents for use therein. More particularly, the present invention provides a method for identifying a gene translocation breakpoint based on the application of a novel multiplex DNA amplification technique. The method of the present invention facilitates not... Agent: Knobbe Martens Olson & Bear LLP

20090203022 - Analysis: A method of analysing a sample includes providing a first part of the sample and a second part of the sample. A first analysis is conducted on the first part of the sample and the results of the first analysis are considered. A second analysis is conducted on the second... Agent: Merchant & Gould PC

20090203027 - Assays for detecting t2r76 taste modulatory compounds: Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods employing the same, and methods for altering taste perception via administration of a T2R76 modulator. These T22R76 polypeptides can be expressed alone or co-expressed with another T2R polypeptide, preferably... Agent: Hunton & Williams LLP Intellectual Property Department

20090203006 - Biological markers of chronic wound tissue and methods of using for criteria in surgical debridement: The present invention relates to methods for identifying tissue sites in a chronic wound that are suitable for debridement and whether debridement procedure has been successful using particular biological markers of the cells within the tissue sites of the chronic wounds.... Agent: Darby & Darby P.C.

20090203020 - Bovine polymorphisms and methods of predicting bovine traits: Methods of predicting the phenotype of a trait in a bovine subject are provided. The methods include obtaining information about polynucleotide sequences specifically regarding the identity of the nucleotides present at one or more identified single nucleotide polymorphisms and using this information to make predictions regarding the trait in the... Agent: Michael Best & Friedrich LLP

20090203025 - Branched and multi-chain nucleic acid switches for sensing and screening: Embodiments of the invention relate to a branched or multichain nucleic acid switch adapted to switch from a first conformation to a second conformation upon ligand binding. The switch includes a probe strand, P, which includes the ligand binding domain; a switching framework which includes a cover strand (C), and... Agent: Knobbe Martens Olson & Bear LLP

20090202987 - Canis sphingosine 1-phosphate receptor isoform 2: A Canis sphingosine-1-phosphate (S1P) receptor isoform 2 (cS1P2), the nucleic acid encoding the cS1P2 receptor, and methods for using the S1P2 receptor and the nucleic acid encoding the cS1P2 receptor in assays for identifying analytes that modulate activity of the cS1P2 receptor. The assays can identify analytes that are useful... Agent: Merck And Co., Inc

20090202997 - Cell-free in vitro transcription and translation of membrane proteins into tethered planar lipid layers: The present invention relates to synthetic membranes having membrane proteins incorporated therein and, in particular, to the cell-free in vitro transcription and translation of membrane proteins into tethered planar lipid layers. In particular, the present invention provides a new method for the preparation of such membranes. The membranes, e.g., can... Agent: Morris Manning Martin LLP

20090203001 - Compositions and methods for diagnosing and treating macular degeneration: The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers (e.g., polymorphisms and/or haplotypes) for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications.... Agent: Casimir Jones, S.c.

20090203023 - Concentrating microorganisms in aqueous solution prior to selective staining and detection: Apparatus and methods for detecting a small number of target microorganisms found in a large volume of aqueous solution by diverting small volumes containing fluorescent microorganisms, including target microorganisms, into a smaller specimen of solution, followed by selectively staining the specimen to tag the target microorganisms and detecting the tagged... Agent: Jennifer L. Bales

20090203021 - Detection of clostridium difficile: The invention provides methods to detect C. difficile in biological samples using real-time PCR. Primers and probes for the detection of C. difficile are provided by the invention. Articles of manufacture containing such primers and probes for detecting C. difficile are further provided by the invention.... Agent: Fish & Richardson P.C.

20090203013 - Detection of methicillin-resistant staphylococcus aureus: The present invention provides improved tests for the detection of methicillin-resistant Staphylococcus aureus. The tests are particularly useful for eliminating false positive results due to the presence of a mixed bacterial population in patient samples.... Agent: Myers Bigel Sibley & Sajovec

20090203000 - Detection of nucleic acids using a cantilever sensor: Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The sensor is prepared by immobilizing a probe material to a surface of the sensor, wherein the probe... Agent: Woodcock Washburn LLP

20090202989 - Egfr and kras mutations: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and KRAS and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of... Agent: Jones Day

20090202996 - Genetic polymorphisms for identifying individuals at risk for drug-induced vestibular dysfunction: In this application is described the identification of genetic variants that contribute to susceptibility to drug-induced vestibular dysfunction, more particularly, GM-induced vestibular dysfunction. Methods, compositions and kits for determining whether an individual has susceptibility for drug-induced vestibular dysfunction are disclosed.... Agent: Sana A. Pratt, Ph.d. Pratt & Associates, Inc.

20090202994 - Human single nucleotide polymorphisms in ion channels and other proteins: The invention provides polynucleotide fragments corresponding to the genomic and/or coding regions of these genes which comprise at least one polymorphic site per fragment. Allele-specific primers and probes that hybridize to these regions, and/or that comprise at least one polymorphic site are also provided. The polynucleotides, primers, and probes of... Agent: Louis J. Wille Bristol-myers Squibb Company

20090203003 - Inhibition of metallo-beta-lactamase: A method to identify a high affinity nucleic acid ligand to inhibit the activity of a lactamase enzyme. The method comprises several steps that initially involve preparing a candidate mixture of nucleic acids. The candidate mixture of nucleic acids is then allowed to make contact with the lactamase enzyme under... Agent: Winstead PC

20090203002 - Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures: The present invention provides a method of selectively amplifying fetal DNA sequences from a mixed, fetal-maternal source. This method utilizes differential methylation to allow for the selective amplification of trophoblast/fetal specific sequences from DNA mixtures that contain a high proportion of non-trophoblast/fetal DNA. The invention also provides methods of using... Agent: Kenyon & Kenyon LLP

20090203012 - Metabolic syndrome genetics: A gene (and polymorphisms within it) was associated with multiple components of the metabolic syndrome. Methods of screening subjects to identify risk of metabolic syndrome and related conditions are described, as are methods of screening compounds to identify those that act on the gene product as a target for the... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B482

20090203014 - Method for diagnosing autism spectrum disorder: The present invention provides methods of diagnosing and/or predicting autism spectrum disorder comprising determining the presence of microdeletions and microduplications on chromosomes 15 and 16.... Agent: David S. Resnick

20090203007 - Method for obtaining and initiating amplification of a target nucleic acid sequence: The present invention relates to oligonucleotides useful for determining the presence of Mycobacterium tuberculosis complex organisms in a test sample. The oligonucleotides of the present invention may be incorporated into detection probes, helper probes, capture probes and amplification oligonucleotides, and used in various combinations thereof.... Agent: Gen Probe Incorporated

20090202998 - Method for the extraction of biomolecules from fixed tissues: The present invention relates to a method for treating a fixed biological sample, comprising the steps of the method: i) provision of a fixed biological sample, ii) contacting the fixed biological sample with an aqueous solution comprising at least one nucleophilic reagent, and iii) heating the biological sample contacted with... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20090203026 - Methods and compositions for targeting secretory lysosomes: This invention relates to methods and compositions for targeting proteins to secretory lysosomes. The invention further provides methods of use in drug screening assays, and methods of purifying secretory lysosomes.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20090203011 - Methods and nucleic acids for analyses of cell proliferative disorders: Particular aspects provide methods, nucleic acids and kits for detecting cell proliferative disorders. Preferred aspects provide genomic sequences, the methylation patterns of which have substantial utility for the improved detection of said disorders, providing for improved diagnosis and treatment of same in patients.... Agent: Davis Wright Tremaine, LLP/seattle

20090203031 - Methods for detecting and quantifying specific microorganisms: Methods and compositions are disclosed for confirming and quantifying the presence of a specific kind of microorganism in a sample of material. Hybridization and polymerase chain reaction (PCR) techniques are applied to identify the presence of the specific microorganism in cultures grown in most probable number and serial dilution methods,... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20090203030 - Methods for detecting and quantifying specific probiotic microorganisms in animal feed: Methods and compositions are disclosed for confirming and quantifying the presence of a specific probiotic microorganism in a sample of animal feed. Hybridization and polymerase chain reaction (PCR) techniques are applied to identify the presence of the specific probiotic microorganism in cultures grown in most probable number and serial dilution... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20090202990 - Methods for the selection of aptamers: The present invention generally relates to methods for selecting aptamers. More specifically, the invention provides methods for the selection of at least one aptamer for use in combination with another epitope binding agent such as another aptamer, an antibody, or a double stranded nucleic acid. The invention also encompasses methods... Agent: Polsinelli Shughart PC

20090203019 - Methods of monitoring metabolic pathways: The present invention provides methods and compositions for monitoring cofactors and metabolites of a metabolic pathway of interest. The subject compositions and methods are particularly suited for monitoring the mevalonate pathway in a variety of cells. The invention also provides fermentation methods for the production of isoprenoids.... Agent: Wilson Sonsini Goodrich & Rosati

20090202986 - Methods of optimizing antibody variable region binding affinity: The present invention provides optimized heteromeric variable region binding fragments and antibodies comprising optimized heteromeric variable region binding fragments. Preferably, the optimized heteromeric variable region binding fragments exhibit optimized activity compared to donor heteromeric variable regions and have unvaried human frameworks. The present invention also provides methods of making the... Agent: Eli Lilly & Company

20090202995 - Molecular cardiotoxicology modeling: The present invention includes methods of predicting cardiotoxicity of test agents and methods of generating cardiotoxicity prediction models using algorithms for analyzing quantitative gene expression information. The invention also includes microarrays, computer systems comprising the toxicity prediction models, as well as methods of using the computer systems by remote users... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090203010 - Msmb-gene based diagnosis, staging and prognosis of prostate cancer: This invention relates generally to a method of diagnosis for distinguishing between a benign prostate hyperplasia and a prostate cancer and between a hormone-sensitive and a hormone-refractory prostate cancer condition and specifically to identification of a hypermethylated (on CpG and non-CpG dinucleotides) CpG island in the beta-microseminoprotein (MSMB) regulatory regions... Agent: Traskbritt, P.C.

20090203015 - Multiplex assays for hormonal and growth factor receptors, and uses thereof: The present invention provides compositions and methods for simultaneously detecting mRNA expression levels of hormonal receptors, particularly both estrogen receptor (ER) and progesterone receptor (PR), optionally in combination with growth factor receptors, particularly epidermal growth factor receptor ERBB2 (Her-2), and further optionally in combination with control genes, such as the... Agent: Celera Corporation

20090203004 - Non-thiopurine methyltransferase related effects in 6-mercaptopurine therapy: The present invention provides methods for predicting tolerance associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. In particular, the present invention provides methods for predicting a patient's risk of an adverse drug reaction (or tolerance) to a 6-mercaptopurine drug by genotyping a patient... Agent: Townsend And Townsend And Crew, LLP

20090203028 - Novel aptamers that bind to listeria surface proteins: Aptamers bind to Listeria surface proteins. A method of assaying a sample for the presence of Listeria monocytogenes includes exposing the sample to an aptamer that specifically binds one of the following proteins: Listeria monocytogenes internalin A protein, Listeria monocytogenes internalin E protein, and Listeria monocytogenes 0610 protein. The presence... Agent: Knobbe Martens Olson & Bear LLP

20090202991 - Novel diagnostic markers, especially for in vivo imaging and assays and methods of use thereof: Novel splice variants as diagnostic markers, preferably membrane-bound. The novel variants according to the present invention may optionally be used for diagnosis of Marker-detectable disease as described herein, optionally through immunohistochemistry.... Agent: Winston & Strawn LLP Patent Department

20090203009 - Novel method for high-throughput integrated chemical and biochemical reactions: The present invention relates to methods for monitoring in a high through-put fashion a multitude of molecular reaction processes, using a substrate, said substrate comprising a plurality of micro-channels, wherein each micro-channel has inlet and outlet open ends on opposing sides of said substrate, and wherein said micro-channels comprise at... Agent: Amster, Rothstein & Ebenstein LLP

20090203005 - Novel method of designing dna probe chip for room temperature hybridization and the dna probe chip: The present invention relates to a method of designing DNA probe chip for room-temperature hybridization in order to solve the solvent evaporation problem occurring when carrying out said hybridization at a high temperature of 40° C.˜50° C. or higher, wherein the method is designed to allow genotyping through hybridizing at... Agent: Blakely Sokoloff Taylor & Zafman LLP

20090203029 - Nucleic acid analysis using non-templated nucleotide addition: One embodiment of the invention is a method of producing an oligonucleotide extended by a single nucleotide base. An oligonucleotide and an extension terminating nucleotide are mixed with an enzyme having terminal transferase activity. The reaction produces an oligonucleotide extended by a single base. The extended oligonucleotide may be used... Agent: Life Technologies Corporation C/o Intellevate

20090203016 - Nucleic acid and corresponding protein entitled 85p1b3 useful in treatment and detection of cancer: A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic and/or therapeutic target for cancers. The 85P1B3 gene or fragment thereof,... Agent: Agensys C/o Morrison & Foerster LLP

20090203018 - Nucleic acid detection assays employing blocker oligonucleotides: The present invention provides methods, compositions, and kits for detecting the presence or absence of target sequences in a sample, where the sample also contains interfering sequences that are similar or identical to the target sequences. In particular, the present invention provides blocker oligonucleotides that at least partially inhibit the... Agent: Casimir Jones, S.c.

20090202992 - Polynucleotide and protein involved in synaptogenesis, variants thereof, and their therapeutic and diagnostic uses: The invention relates to a kit for diagnosing autism linked to a mutation in a protein belonging to the family of human neuroligins.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090203008 - Rapid method to determine inhibitor sensitivity of ns3/4a protease sequences cloned from clinical samples: A method for measuring HCV NS3/4A activity from a HCV NS3/4A sequence, comprising obtaining and cloning the sequence into a mammalian expression vector, transiently transfecting a mammalian cell with the vector, which includes a reporter construct encoding a HCV NS3/4A cleavage site fused to a detectable label, measuring signal production... Agent: Merck And Co., Inc

20090203024 - Secreted protein called 36p6d5 characteristic of tumors: Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, breast, colon, ovary, and pancreas.... Agent: Agensys C/o Morrison & Foerster LLP

20090203032 - Species-specific primer sets and identification of species-specific dna sequences using genome fragment enrichment: Targeted sequencing of genetic regions that differ between two DNA preparations uses genomic fragment enrichment. This method can be used to study genetic variation among closely related species and microbial communities, particularly for identifying sources of fecal pollution.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090203033 - Test and model for alzheimer's disease: The invention provides an isolated nucleic acid characteristic of human amyloid precursor protein 770 including the nucleotides encoding codon 670 and 671, wherein the nucleic acid encodes an amino acid other than lysine at codon 670 and/or an amino acid other than methionine at codon 671. Also provided is a... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20090202988 - Trap vectors and gene trapping using the same: A trap vector containing a loxP sequence composed of inverted repeat sequence 1, a spacer sequence and inverted repeat sequence 2 in this order, the loxP sequence being a mutant loxP wherein a part of the inverted repeat sequence 1 or 2 is mutated.... Agent: Birch Stewart Kolasch & Birch

20090202993 - Use of dna polymerases: Use of a DNA polymerase enzyme as a single stranded RNA exoribonuclease.... Agent: Crowell & Moring LLP Intellectual Property Group

20090203017 - Use of nucleic acid probes to detect nucleotide sequences of interest in a sample: The invention relates to methods for the determination and detection of nucleic acids sequences in a sample. The nucleic acid may be RNA or DNA or both. The invention also relates to methods for the determination of the presence and species of various microorganisms in a sample. We have also... Agent: Loeb & Loeb, LLP

20090203037 - Anti-t. cruzi antibodies and methods of use: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.... Agent: Paul D. Yasger Abbott Laboratories

20090203036 - Epitope regions of a thyrotrophin (tsh) receptor, uses thereof and antibodies thereto: The present invention is concerned with epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto.... Agent: Merchant & Gould PC

20090203035 - Fluorescent proteins with increased photostability: The present invention relates to novel fluorescent protein variants of DsRed and eqFP578. Fluorescent protein variants having increased photostability and/or having reversible photoswitching behavior, as well as polynucleotides encoding such variants are provided herein. Methods of using these novel fluorescent protein variants and methods for constructing other fluorescent protein variants... Agent: Townsend And Townsend And Crew, LLP

20090203039 - Monoclonal antibody to soluble lox-1: It is intended to provide a monoclonal antibody that specifically recognizes human soluble LOX-1, particularly a monoclonal antibody with a dissociation constant (Kd) for human soluble LOX-1 of 1×10−9 (M) or less. The antibody can be produced from a hybridoma prepared by a method including the following steps of: (1)... Agent: Merchant & Gould PC

20090203038 - Negative mimic antibody for use as a blocking reagent in bnp immunoassays: The present disclosure relates to isolated antibodies that do not bind to brain natriuretic peptide that can be used as a reagent to reduce heterophilic interference in an immunoassay.... Agent: Paul D. Yasger Abbott Laboratories

20090203034 - Reagents for the detection of tyrosine phosphorylation in brain ischemia signaling pathways: The invention discloses 99 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Brain Ischemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20090203041 - Bmp4 inhibitors: A fragment of Gremlin having the sequence of amino acids shown in SEQ ID NO:2 or a functional subsequence of the fragment is described. The fragment is capable of altering BMP4 activity. Also provided is a polynucleotide encoding the fragment. Also disclosed is an assay for testing a molecule for... Agent: Michael Best & Friedrich LLP

20090203040 - Detection of specific nitrated markers: Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to... Agent: Jacobson Holman PLLC

20090203042 - Novel bt toxin receptors from lepidopteran insects and methods of use: The invention relates to Bt toxin resistance management. The invention particularly relates to the isolation and characterization of nucleic acid and polypeptides for a novel Bt toxin receptor. The nucleic acid and polypeptides are useful in identifying and designing novel Bt toxin receptor ligands including novel insecticidal toxins.... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20090203047 - 88kda tumorigenic growth factor and antagonists: This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expression or action. Antagonists to an 88 KDa autocrine growth and tumorigenicity stimulator are provided which inhibit its expression or biological activity. The antagonists include antisense oligonucleotides and... Agent: Womble Carlyle Sandridge & Rice, PLLC

20090203049 - Beta integrin gene and protein: Recombinant materials for the production of β integrin protein characteristic of Manduca sexta are useful for screening pesticides for this moth.... Agent: Morrison & Foerster LLP

20090203046 - Methods for identifying purkinje cells using the corl2 gene as a target: Total RNAs were prepared from the ventral and dorsal regions of embryonic day 12.5 mouse mesencephalon, and a cDNA fragment was obtained by the subtraction method (N-RDA). The full-length cDNA was cloned and the nucleotide sequence was determined. The gene was named Corl2. The result of homology search showed that... Agent: Townsend And Townsend And Crew, LLP

20090203048 - Screening assays for antioxidants and antiproliferative compounds: Provided are screening assays for identifying and evaluating compounds with antioxidant and/or antiproliferative activities.... Agent: Fish & Richardson PC

20090203050 - Molecular signaling pathways triggered by rituximab: prognostic, diagnostic, and therapeutic uses: The present invention provides markers associated with activated molecular signaling pathways (example: p38 MAKP, NF-κB, ERK1/2, YY-1 and AKT) inhibited by rituximab in cancer cells as well as pathways activated by rituximab (such as death receptors, RKIP, PTEN) all of which are associated with the regulation of chemo and immunoresistance.... Agent: Townsend And Townsend And Crew, LLP

20090203051 - Targets in breast cancer for prognosis or therapy: Cancer markers are developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genome wide analyses of genome copy number and gene expression in breast cancer revealed 66 genes in the human chromosomal regions, 8p11, 11q13, 17q12, and 20q13 that were amplified. Diagnosis and assessment... Agent: Townsend And Townsend And Crew, LLP

20090203052 - Novel soluble cd14 antigen: n

20090203043 - Protein phosphorylation by basophilic serine/threonine kinases in insulin signaling pathways: The invention discloses 142 novel phosphorylation sites identified in insulin signaling pathways, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20090203044 - Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor: Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations... Agent: Seed Intellectual Property Law Group PLLC

20090203045 - Crystal structure of soluble glutaminyl cyclase: A crystalline structure of glutaminyl cyclase (QC) is described. Also described are the methods of preparing the crystalline structure of QC and the methods for identifying candidate inhibitors of QC. In addition, a structural basis for the rational design or identification of new inhibitors that may be used to treat... Agent: Panitch Schwarze Belisario & Nadel LLP

20090203053 - Methods and materials for amplification of a signal in an immunoassay: Ultrafine particles are provided having a core region that has a signal amplifying molecule and a shell region that surrounds the core region. The shell region has at least one antibody affixed to its surface that is specific for at least one antigen. Alternatively, the ultrafine particles may entrap the... Agent: K&l Gates LLP

20090203054 - Hdl cholesterol sensor using selective surfactant: A method for the determination of the amount of cholesterol in high density lipoproteins in a high density lipoprotein containing sample, said method comprising reacting the sample with a surfactant which selectively reacts with high density lipoproteins in the sample, said surfactant being selected from sucrose esters, and maltosides, and... Agent: Quarles & Brady LLP

20090203055 - Compositions and methods for rna interference with sialidase expression and uses thereof: The present invention provides RNAi agents targeted to sialidase. The RNAi agents include siRNA, shRNA, and expression vectors that comprise a template for transcription of an siRNA or shRNA. The invention further provides cells and cell lines that comprise an RNAi agent targeted to sialidase. The cells and cell lines... Agent: Choate, Hall & Stewart LLP

20090203056 - Kit for diagnosis of cancer: The present invention relates to a kit for assaying the activity of the human arylsulphatase or its isozymes, including 4-MUS and 4-MU. The kit can be used for initial screening, therapeutic effect monitoring and recurrence inspecting of human cancers.... Agent: Wang & Ho

20090203057 - Protein demethylases comprising a jmjc domain: Post-translational modification, including protein methylation, plays an important role in regulating protein function. The present invention provides a novel assay for evaluating demethylase activity and the discovery of a family of protein demethylases comprising a novel demethylase motif.... Agent: Myers Bigel Sibley & Sajovec

20090203058 - Method for determination of allergen in environment and kit for simple quantification of allergen: A simple method for measuring allergens is disclosed, by which the amount of environmental allergens can be measured simply without using an anti-allergen antibody. In the method for measuring an environmental biological allergen(s), a solution containing a substrate of a protease which the allergen(s) has (have) is brought into contact... Agent: Birch Stewart Kolasch & Birch

20090203059 - Protease detection product: A protease detection product (1) for detecting a protease enzyme in a sample. The protease detection product (1) comprises a medium (2) providing a liquid flow path; a labelled component (6) located on the liquid flow path; a capture component (12) located downstream of the labelled component (6) and immobilisation... Agent: Clark & Elbing LLP

20090203060 - Evaluating mmp expression in patient stratification and other therapeutic, diagnostic and prognostic methods for cancer: Provided are compositions, methods and kits for quantifying the expression and/or activity of MMP-14 and other biomarkers of cancer, which may be used diagnostically and prognostically, e.g., in patient stratification and evaluation of appropriate therapeutic regimens.... Agent: Lando & Anastasi, LLP

20090203061 - Device and method for observing the organization of studied cells cultured in the presence of a concentration gradient of chemotactic molecules: The device comprises a cell culture compartment (10) and a diffusion compartment (20) in fluid communication with the cell culture compartment (20) through a filtering element (22) for the progressive diffusion of chemotactic molecules contained in the diffusion compartment into a culture medium contained in the culture compartment, so as... Agent: Stites & Harbison PLLC

20090203063 - Droplet-based cell culture and cell assays using digital microfluidics: We introduce a new method for implementing cell-based assays and long-term cell culture. The method is based on digital microfluidics (DMF) which is used to actuate nanoliter droplets of reagents and cells on a planar array of electrodes. DMF method is sutable for assaying and culturing both cells in suspension... Agent: Ralph A. Dowell Of Dowell & Dowell P.C.

20090203064 - Method and device for monitoring platelet function: The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in the passageway to generate a platelet mass in the passageway, and monitoring the flow or composition of the... Agent: Popovich, Wiles & O'connell, PA 650 Third Avenue South

20090203062 - Method for identifying and/or quantifying anti-infective compounds: The present invention relates to a method for identifying and/or quantifying an anti-infective compound. Furthermore it relates to a method for identifying and/or quantifying a mutation in a virulence factor of a pathogen of a host organism that reduces the virulence of the pathogen to a unicellular test organism.... Agent: Swanson & Bratschun, L.L.C.

20090203065 - Cell culture article and screening: A method for producing a cell culture article having a synthetic polymer layer for incubating with cells includes diluting one or more (meth)acrylate monomers in a solvent and dispersing the diluted monomers on a surface of the cell culture article. Some or substantially all of the solvent is removed and... Agent: Corning Incorporated

20090203066 - Method for preparing a sample: A method for preparing a sample consisting of biological tissue in a solid matrix includes steps of: contacting the sample with a first compressed fluid stream wherein the matrix is soluble so as to extract the solid matrix, contacting the sample with a second compressed fluid, adapted to impregnate the... Agent: Young & Thompson

20090203067 - Photobioreactor systems and methods for growing organisms: Photobioreactors and systems for growth of a photosynthetic organism are provided herein. The systems and photobioreactors can comprise features and modifications in order to improve photosynthetic growth efficiency and light energy utilization. Also provided are methods and systems to improve the cost-effectiveness of a photobioreactor system for growth of a... Agent: Wilson Sonsini Goodrich & Rosati

20090203068 - High pressure enzymatic digestion system for protein characterization: A method and system for obtaining samples for proteomic analysis that utilizes pressure and a preselected agent to obtain a processing sample in a significantly shorter period of time than prior art methods and which maintains the integrity of the processing sample through the preparatory process. In one embodiment of... Agent: Battelle Memorial Institute Attn:IPServices, K1-53

20090203074 - Bacillus host cell: A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more secreted polypeptide(s) which is at least 80% identical to one or more of the polypeptides shown in SEQ ID NO's: 2... Agent: Novozymes North America, Inc.

20090203072 - Detection for hpv-induced invasive cancers and their precursor lesions with invasive potential: This invention provides a method of detecting an HPV-induced invasive cancer or precursor lesion thereof associated with tumor suppressor lung cancer 1 (TSLC1) in a subject in need thereof. The method comprises contacting a cell component of a test cell of the subject with a reagent that detects the level... Agent: Cooper & Dunham, LLP

20090203071 - Expression in insect cells of genes with overlapping open reading frames, methods and compositions therefor: The present teachings disclose nucleic acid cassettes for expressing in an insect cell a plurality of polypeptides encoded by a gene comprising overlapping open reading frames (ORFs). A cassette comprises, in 5′ to 3′ order, a) a first insect cell-operable promoter, b) a 5′ portion of a gene comprising a... Agent: Sonnenschein Nath & Rosenthal LLP

20090203073 - Gene encoding g-protein coupled receptor and gene product thereof: The present invention, the objects of which are to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein, and to provide a useful... Agent: Kilyk & Bowersox, P.l.l.c.

20090203075 - Genes conferring herbicide resistance: Compositions and methods for conferring herbicide resistance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a polypeptide that confers resistance or tolerance to glyphosate herbicides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and... Agent: Alston & Bird LLP

20090203070 - Hyperphotosynthetic organisms: The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance,... Agent: Fenwick & West LLP

20090203069 - Organic compounds: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically... Agent: Birch Stewart Kolasch & Birch

20090203076 - Compositions and methods for increasing protein production: Compositions and methods for increasing protein production are provided.... Agent: Dann, Dorfman, Herrell & Skillman

20090203077 - Method of producing factor viii proteins by recombinant methods: Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked to a promoter, wherein the promoter is characterized by the ability to produce commercially viable Factor VIII protein; and incubating the... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20090203078 - Process for producing polypeptide: The present invention relates to a process for producing a desired polypeptide using rat cells. Specifically, the present invention relates to a process for producing the polypeptide which comprises culturing rat cells such as YB2/3HL.P2.G11.16Ag.20 (hereinafter referred to as YB2/0), preferably rat cells to which a recombinant DNA comprising DNA... Agent: Sughrue-265550

20090203079 - Transgenic monocot plants encoding beta-glucosidase and xylanase: Plant proteins isolated from monocot plants from transformation of the monocot plant with DNA at least 80% homologous to the bglA gene encoding β-glucosidase from a rumen bacterium which is Butyrivibrio fibrisolvens H17c and targeted to a subcellular compartment. The transformed plant is ground after the β-glucosidase has been accumulated,... Agent: Ian C. Mcleod Ian C. Mcleod, P.C.

20090203080 - S-adenosylmethionine synthetase mutants, the dnas encoding the same and uses of the mutants: The invention discloses a series of Methanococcus jannaschii S-adenosylmethionine synthetase mutants with improved thermostability and high catalytic activity obtained by using gene mutation technique, characterized in that these mutants refer to an enzyme using Sequence 2 in the Sequence Listing as the reference sequence and contains at least one mutation... Agent: The Webb Law Firm, P.C.

20090203081 - Inducible expression vectors and methods of use thereof: The present invention provides nucleic acids that include a promoter that is inducible by a transcriptional activator protein; and a nucleotide sequence that encodes the transcriptional activator protein. The present invention provides expression vectors that provide for inducible production of gene products in a host cell. The present invention further... Agent: Uc Berkeley - Otl Bozicevic, Field & Francis LLP

20090203085 - Isothermal nucleic acid amplification methods and compositions: Methods and compositions are provided related to the amplification of target polynucleotide sequences as well as total RNA and total DNA amplification. In some embodiments, the methods and compositions also allow for the immobilization and capture of target polynucleotides with defined 3′ and or 5′ sequences to solid surfaces. The... Agent: Wilson Sonsini Goodrich & Rosati

20090203084 - Methods and apparatuses for convective polymerase chain reaction (pcr): The present invention provides a method and apparatus for amplifying a nucleic acid sequence by polymerase chain reaction (PCR). The method comprises placing a PCR sample in a container which is heated by only a single heat source that provides a high temperature for denaturation in the bottom of the... Agent: Occhiuti Rohlicek & Tsao, LLP

20090203083 - Substrate for nucleic acid amplification: The present invention relates to a method, a substrate, a kit, and a system for nucleic acid amplification comprising a porous substrate with pores enabling the diffusion of biomolecules. More particular, the present invention relates to a method, a substrate, a kit and a system, wherein the nucleic acid amplification... Agent: Roche Diagnostics Operations Inc.

20090203082 - Thermocycling of a block comprising multiple sample: The present invention relates to the field of high throughput analysis of samples. In particular, the present invention is directed to a device, a System and a method for simultaneous tempering of multiple samples. More particular, the invention relates to the simultaneous thermocycling of multiple samples to perform PCR in... Agent: Dinsmore & Shohl, LLP One Dayton Centre

20090203086 - System and method for improved signal detection in nucleic acid sequencing: An embodiment of a system for reducing crosstalk in a parallel sequencing platform is described that comprises a substrate with a plurality of individual reaction environments that include a species of nucleic acid template, and a plurality of spatially localized reactants, wherein the localized reactants minimize the transmission of reaction... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090203087 - Expression of granular starch hydrolyzing enzymes in trichoderma and process for producing glucose from granular starch substrates: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity (GSHE). Further the invention relates to a method for producing a glucose syrup comprising contacting a granular starch slurry obtained from a granular... Agent: Danisco US Inc. Attention: Legal Department

20090203088 - Heterologous alpha amylase expression in aspergillus: The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same.... Agent: Danisco US Inc. Attention: Legal Department

20090203089 - Isolated alcohol dehydrogenase enzymes and uses thereof: Bacterial polynucleotides and polypeptides are provided in which the polypeptides have a dehydrogenase activity, such as an alcohol dehydrogenase (ADH) activity, an uronate, a 4-deoxy-L-erythro-5-hexoseulose uronate (DEHU) ((4S,5S)-4,5 dihydroxy-2,6-dioxohexanoate) hydrogenase activity, a 2-keto-3-deoxy-D-gluconate dehydrogenase activity, a D-mannuronate hydrogenase activity, and/or a D-mannnonate dehydrogenase activity. Methods, enzymes, recombinant microorganism, and microbial... Agent: Seed Intellectual Property Law Group PLLC

20090203090 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family: A method for producing an L-amino acid is described, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine, L-tryptophan, or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of a wild-type alcohol dehydrogenase encoded by the adhE gene or a mutant... Agent: Cermak & Kenealy LLP Acs LLC

20090203091 - Mutants for the preparation of d-amino acids: The present invention relates to specific Escherichia. coli mutants which can be used for the synthesis of D-amino acids, and to such a process. The mutants are distinguished by deficiencies in particular enzymes which break down D-amino acids and include those which produce D-amino acids via the carbamoylase/hydantoinase route.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090203092 - Liquid biofuel mixture and method and device for producing the same: e

20090203093 - Protein targeting to lipid bodies: The present invention relates to a method of targeting a protein of interest to an intracellular hydrophobic inclusion body of a bacterial cell by means of a fusion protein comprising a hydrophobic targeting peptide operatively linked with said protein of interest; methods of microbial production of a lipophilic compound of... Agent: Connolly Bove Lodge & Hutz, LLP

20090203094 - Use of genes for increasing the oil content in plants: The invention relates to methods for increasing the oil content in plants, preferably in plant seeds, by expressing the Ypr140w polypeptide from yeast or corresponding polypeptides from plants. The invention furthermore relates to expression constructs for expressing the yeast polypeptide Ypr140w or corresponding polypeptides from plants in plants, preferably in... Agent: Connolly Bove Lodge & Hutz, LLP

20090203095 - Novel engineered microorganism producing homo-succinic acid and method for preparing succinic acid using the same: The present invention relates to a mutant microorganism, which is selected from the group consisting of genus Mannheimia, genus Actinobacillus and genus Anaerobiospirillum, producing homo-succinic acid and a method for producing homo-succinic acid using the same, and more particularly to a mutant microorganism producing succinic acid at a high concentration... Agent: Moore & Van Allen PLLC

20090203096 - Process for production of optically active alcohol: The present invention provides methods for producing (S)-1,1,1-trifluoro-2-propanol, which include the step of reacting an enzyme of any one of alcohol dehydrogenase CpSADH, alcohol dehydrogenase ReSADH, carbonyl reductase ScoPAR, (2S,3S)-butanediol dehydrogenase ZraSBDH, carbonyl reductase ScGCY1, tropinone reductase HnTR1, tropinone reductase DsTR1, or alcohol dehydrogenase BstADHT, a microorganism or a transformant... Agent: Foley And Lardner LLP Suite 500

20090203098 - Indirect production of butanol and hexanol: A process for the conversion of carbohydrates from any of a number of sources into butanol and hexanol for fuel or chemical use is disclosed. The process includes conducting a homoacetogenic fermentation to produce an acetic acid intermediate which is chemically converted to ethanol. The ethanol and a remaining portion... Agent: Sheridan Ross PC

20090203097 - Strain for butanol production: Screening of fatty acid fed bacteria which are not natural butanol producers identified increased membrane cyclopropane fatty acid as providing improved butanol tolerance. Increasing expression of cyclopropane fatty acid synthase in the presence of the enzyme substrate that is either endogenous to the cell or fed to the cell, increased... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090203100 - Microbial fermentation of gaseous substrates to produce alcohols: The present invention relates to methods for increasing the efficiency of anaerobic fermentation processes (1) that produce acetate as a by-product in addition to a desired product, and (2) that can utilise hydrogen and/or carbon dioxide in the fermentation. The method comprises the steps of converting acetate produced by the... Agent: Occhiuti Rohlicek & Tsao, LLP

20090203099 - Zymomonas with improved ethanol production in medium containing concentrated sugars and acetate: Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas strains further engineered to reduce activity of the himA gene were found to have increased ethanol production in comparison to a parental strain, when... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090203101 - Enzyme blends for fermentation: The present invention relates to an enzyme blend composition comprising a glucoamylase, an acid stable alpha amylase, and an acid fungal protease. The present invention is further directed to a method for producing end products such as alcohols from fermentable sugars, comprising the steps of: (a) contacting a slurry comprising... Agent: Danisco US Inc., Genencor Division

20090203102 - Compositions and methods for producing isoprene: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.... Agent: Morrison & Foerster LLP

20090203103 - Induction and stabilization of enzymatic activity in microorganisms: The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase... Agent: Fish & Richardson P.C.

20090203104 - Tab molecules: The present invention relates to TAB molecules, ADEPT constructs directed against TAG-72, and their use in therapy.... Agent: Elena E. Quertermous Genencor International, Inc

20090203105 - Ura5 gene and methods for stable genetic integration in yeast: A novel gene encoding P. pastoris orotate-phosphoribosyl transferase (URA5) is disclosed. Methods for producing and selecting yeast strains capable of stable genetic integration of heterologous sequences into the host genome are also provided.... Agent: Merck And Co., Inc

20090203106 - Galactanase variants: The present invention relates to variants of Glycoside Hydrolase family 53 galactanases, e.g., variants of the galactanases from strains of Yersinia, Aspergillus, Humicola, Meripilus, Myceliophthora, Thermomyces, Bacillus, Bifidobacterium, Cellvibrio, Clostridium, Pseudomonas, Thermotoga, or Xanthomonas.... Agent: Novozymes North America, Inc.

20090203109 - Alpha-amylase variants: The invention relates to a variant of a parent Termamyl-like α-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an α-amylase variant of... Agent: Novozymes North America, Inc.

20090203108 - Method for preparing maltogenic alpha-amylase variants: The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties., e.g. an altered pH optimum, improved thermostability, increased specific activity, an altered cleavage pattern or an... Agent: Novozymes North America, Inc.

20090203107 - Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic... Agent: Traskbritt / Battelle Energy Alliance, LLC

20090203110 - Composition exhibiting a von willebrand factor (vwf) protease activity comprising a polypeptide chain with the amino acid sequence aaggilhlellv: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.... Agent: Baxter Healthcare Corporation

20090203111 - Subtilases: The present invention relates to methods for producing variants of a parent JP170 subtilase and of a parent BPN′ subtilase and to JP170 and BPN′ variants having altered properties as compared to the parent JP170/BPN′ subtilase.... Agent: Novozymes North America, Inc.

20090203113 - Chimeric papillomavirus-like particles: The present invention provides a papillomavirus-like particle, characterized as having conformational epitopes, comprising a papillomavirus L1 product and a papillomavirus L2 fusion product; and related synthetic DNA molecules, host cells, methods and vaccines.... Agent: Knobbe, Martens, Olson & Bear, LLP

20090203114 - Novel methods and interferon deficient substrates for the propagation of viruses: The present invention relates, to novel methods and substrates for the propagation of viruses. The invention relates to IFN-deficient substrates and methods for propagating viruses in these unconventional substrates. In particular, the invention relates to methods of propagating viruses in immature embryonated eggs, preferably six- to nine-day-old chicken eggs. The... Agent: Jones Day

20090203112 - Vero cell line which is adapted to grow in suspension: The invention relates to a Vero cell line that can be grown in serum-free and protein-free culture and in suspension culture in the absence of carrier for its adherence, and to production of viral vaccines using said cell line. More particularly, the present invention relates to establishment of a cell... Agent: Ratnerprestia

20090203115 - Hydroponic growing enclosure and method for growing, harvesting, processing and distributing algae, related microrganisms and their by products: Systems and methods for hydroponically growing microorganisms within a self-contained air-supported structure, in which microorganisms are grown in an organic slurry, harvested, and processed to obtain and process and distribute molecules useful for biofuel or other purposes.... Agent: Lewis, Rice & Fingersh, Lc Attn: BoxIPDept.

20090203116 - System to improve algae production in a photo-bioreactor: This invention provides a method of delivering light internally to a Photo-Bioreactor growing algae for production of Biodiesel fuel. The invention also provides an improved method of delivering liquid nutrients [I.e. sewage] and carbon dioxide to the growing algae in a Photo-Bioreactor. These results are achieved by a single system... Agent: Keith Bazaire

20090203117 - Apparatus for processing biological material: The present invention relates to an apparatus for processing biological materials, comprising a platform having a plurality of sample receiving areas located thereon, each sample receiving area being substantially enclosed in a holding means, the apparatus also having at least one liquid carrier member mounted for supplying liquid to and/or... Agent: John S Hale Gipple & Hale

20090203118 - Optical system including nanostructures for biological or chemical sensing: An analytical device is disclosed. In one embodiment, the analytical device includes a three-dimensional substrate structure comprising a three-dimensional surface. A plurality of noble metal nanoparticles are on the three-dimensional substrate structure. A plurality of capture agents are on the noble metal nanoparticles.... Agent: Townsend And Townsend And Crew, LLP

20090203119 - Biomass reactor: A reactor for the conversion of biomass material includes an elongate annular chamber with an inner wall and an outer casing. A screw conveyor extends from one end into the chamber to feed biomass material. A heat source is provided within the inner wall of the chamber, and may be... Agent: Charter Ip, LLC

20090203120 - Thermal cycling apparatus and method for providing thermal uniformity: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.... Agent: Life Technologies Corporation C/o Intellevate

20090203121 - Nucleic acid agents for downregulating h19, and methods of using same: Isolated oligonucleotides capable of down-regulating H19 mRNA in cancer cells are disclosed, as well as pharmaceutical compositions that include the oligonucleotides and methods of treatment of cancer using them. Methods of treating cancer comprising administering agents capable of downregulating H19 mRNA in combination with an additional anti-cancer treatment are further... Agent: Winston & Strawn LLP Patent Department

20090203126 - Cell culture array system for automated assays and methods of operation and manufacture thereof: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation. In one embodiment, three wells are used for independent cell culture systems in a cell culture array. In a second aspect, artificial sinusoids with artificial epithelial barriers are provided with just one (optionally shared or... Agent: Quine Intellectual Property Law Group, P.C.

20090203123 - Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.... Agent: Fulbright & Jaworski, LLP

20090203124 - Mage-a3 peptides presented by hla-dr1 molecules: The invention describes HLA class II binding peptides encoded by the MAGE tumor associated genes, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized... Agent: Wolf Greenfield & Sacks, P.C.

20090203125 - Mig-7 as a specific anticancer target: Aspects of the present invention provide novel Mig-7 encoding nucleic acids and Mig-7 polypeptides, recombinant DNA expression systems and host cells containing same, as well as methods of inhibiting expression of the subject nucleic acid molecules, inhibiting production of the encoded proteins or polypeptides, inhibiting metastasis of a carcinoma cell... Agent: Seed Intellectual Property Law Group PLLC

20090203129 - Multipotent adult stem cells and methods for isolation: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.... Agent: Thompson Hine L.L.P. Intellectual Property Group

20090203130 - Multipotent adult stem cells and methods for isolation: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.... Agent: Thompson Hine L.L.P. Intellectual Property Group

20090203127 - Nematode fatty acid desaturase-like sequences: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as arc vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid... Agent: Fish & Richardson PC

20090203128 - Nogo-receptors and methods of use: Disclosed are compositions relating to the Nogo receptor (NgR) family as well as fragments, chimeras, and variants thereof. The invention provides polypeptides, nucleic acids, vectors, expression systems, and antibodies and antibody fragments related to the NgRs as well as uses thereof. Such uses include modulation neurite outgrowth in a subject... Agent: Fish & Richardson P.C.

20090203122 - Peripheral nervous system specific sodium channels, dna encoding therefor, crystallization, x-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof: Cloning, expression, viral and delivery vectors and hosts which contain nucleic acid coding for at least one peripheral nervous system specific (PNS) sodium channel peptide (SCP), isolated PNS SCP, and compounds and compositions and methods, are provided, for isolating, crystallizing, x-ray analysing molecular modeling, rational drug designing, selecting, making and... Agent: Townsend And Townsend And Crew, LLP

20090203137 - Compounds for the modulation of beta-catenin expression: The invention relates to oligomer compounds (oligomers), which target beta-catenin mRNA in a cell, leading to reduced expression of beta-catenin. Reduction of beta-catenin expression is beneficial for a range of medical disorders, such as hyperproliferative disorders, such as cancer. The invention provides therapeutic compositions comprising oligomers and methods for modulating... Agent: Dechert LLP

20090203133 - Determinants of sensitivity to chemotherapeutic agents: The present invention provides methods for determining the level of resistance of a tumour cell to one or more chemotherapeutic agents, comprising measuring the level of expression of a muscle ankyrin repeat protein in the tumour cell. The invention also provides methods for increasing the sensitivity of a tumour cell... Agent: Seed Intellectual Property Law Group PLLC

20090203135 - Glycoconjugates of rna interference agents: The present invention relates to agents, compositions and methods for inhibiting the expression of a target gene, comprising an RNAi agent bearing at least one galactosyl moiety. These are useful for delivering the gene expression inhibiting activity to cells, particularly hepatocytes, and more particularly in therapeutic applications.... Agent: Nixon Peabody LLP

20090203136 - Modulating immune system development and function through microrna mir-146: The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments,... Agent: Knobbe Martens Olson & Bear LLP

20090203131 - Polyamides for nucleic acid delivery: The present invention describes reagents and methods for using concatermized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end copies of a short dsDNA containing a sequence or sequences that act as transcription factor decoys.... Agent: Dinsmore & Shohl LLP

20090203132 - Pyrrolidinyl groups for attaching conjugates to oligomeric compounds: The present invention provides pyrrolidinyl compounds that are useful for preparing conjugated oligomeric compounds. The conjugated pyrrolidinyl compounds can be attached to support medium and provide a free hydroxyl for oligomer synthesis to prepare an oligmeric compound having a 3′-conjugate. Alternatively, the pyrrolidinyl compound can be prepared as a phosphoramidite... Agent: Woodcock Washburn LLP

20090203134 - Remedy for nerve cell regeneration: Wnt3a proteins represented by SEQ ID NO:2, etc. are used as the active ingredient of remedy for nerve cell regeneration, in particular, remedy for retinal cell regeneration which is useful in treating retinitis pigmentosa, age-related macular degeneration, cone dystrophy and so on.... Agent: Knobbe Martens Olson & Bear LLP

20090203138 - Small interfering rnas targeting feline herpes virus: The present application provides polynucleotides, compositions thereof and methods of treating feline herpes virus infections. In certain embodiments, the polynucleotides and compositions thereof can be used to reduce replication of feline herpes simplex virus 1 (FHV-1) in vivo and/or in vitro.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090203139 - Production of four carbon alcohols using improved strain: Using screening of transposon random insertion mutants, genes involved in accumulation of (p)ppGpp were found to be involved in bacterial cell response to butanol. Reduced production of proteins with enzymatic activity for (p)ppGpp biosynthesis confers increased butanol tolerance. Bacterial strains with reduced (p)ppGpp accumulation and having a butanol or 2-butanone... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090203140 - Genomic editing in zebrafish using zinc finger nucleases: Disclosed herein are methods and compositions for genomic editing of one or more genes in zebrafish, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.... Agent: Robins & Pasternak

20090203141 - Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant rna agents: The present invention generally relates to a method for developing, generating and selecting tumor-free embryonic stem (ES)-like pluripotent cells using electroporation delivery of an inducible tumor suppressor mir-302 agent into mammalian cells. More particularly, the present invention relates to a method and composition for generating a Tet-On/Off recombinant transgene capable... Agent: Birch Stewart Kolasch & Birch

20090203142 - Nucleotide sequences of a new class of diverged delta-9 stearoyl-acp desaturase genes: An isolated nucleic acid fragment encoding a diverged delta-9 fatty acid desaturase is disclosed. Also the construction of a chimeric gene encoding all or a portion of the diverged delta-9 fatty acid desaturase is disclosed, in sense or antisense orientation, wherein expression of the chimeric gene results in production of... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090203143 - Trans-splicing mediated photodynamic therapy: The present invention provides methods and compositions for conferring selective death on cells expressing a specific target precursor messenger RNA (selective target pre-mRNA). The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) expressed within a cell and mediate... Agent: Saul Ewing LLP (baltimore) Attn: Patent Docket Clerk

20090203144 - Hiv-gag codon-optimised dna vaccines: The invention provides a nucleotide sequence that encodes an HIV-1 gag protein or fragment thereof containing a gag epitope and a second HIV antigen or a fragment encoding an epitope of said second HIV antigen, operably linked to a heterologous promoter. Preferred polynucleotide sequences further encodes nef or a fragment... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

  
08/13/2009 > patent applications in patent subcategories. inventions list

20090202976 - Amniopunch and uses thereof: A tissue, such as an amniotic or chorionic membrane, harvesting device that integrates a system facilitating subsequent storage of tissue samples. The device cuts a sample of the target tissue and automatically deposits the sample in a storage vessel. A method of collecting and storing a sample from a target... Agent: Sonnenschein Nath & Rosenthal LLP

20090202977 - Decellularization and recellularization of organs and tissues: The invention provides for methods and materials to decellularize a solid organ and to recellularize such a decellularized organ to thereby generate a solid organ.... Agent: Fish & Richardson P.C.

20090202978 - Method and apparatus for freezing of a biological material: e

20090202982 - Blood-viscosity reducing agent: A blood-viscosity reducing agent contains a protein derived from Bacillus subtilis natto and including, sequentially from an amino group terminal, a first structural amino acid sequence having alanine, threonine, aspartic acid, glycine, valine, glutamic acid, tryptophan, asparagine, valine, aspartic acid, glutamine, isoleucine, aspartic acid, alanine, proline, lysine, alanine, tryptophan, alanine,... Agent: Blakely Sokoloff Taylor & Zafman LLP

20090202980 - Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with: The invention relates to the field of biochemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-β structures and the biological role of these cross-β structures.... Agent: Traskbritt, P.C.

20090202979 - Production of antibody formats and immunological applications of said formats: The invention concerns an in-vitro method for introducing a targeted genome modification into an oocyte or an egg and a method for performing a random insertion in the genome of a host cell.... Agent: Harness, Dickey & Pierce, P.L.C

20090202981 - Triple spin, double pool and revolumization process for concentrating platelets and derivative platelet concentrate: The present invention comprises an improved method of manufacturing platelet concentrate comprising the steps of: performing a first centrifugation of anticoagulated blood, pooling a first platelet rich sample, performing a second centrifugation on the first platelet rich sample whereby the volume of the first platelet rich sample placed in each... Agent: Laurence C. Bonar

20090202985 - Method and apparatus for detecting an electric field fluctuation associated with the permeabilization of a bacterial cell wall: A sensor for detecting an electric field fluctuation associated with the permeabilization of a bacterial cell wall comprises a substrate, at least two electrodes integrated on the substrate, an amplifier integrated on the substrate, and a processor electrically connected to the amplifier to analyze the amplified signal. The substrate and... Agent: Bereskin And Parr LLP/s.e.n.c.r.l., S.r.l.

20090202983 - Method for determining the concentration of virus particles/virus antigens: The invention provides a method for determining the concentration of virus particles and/or virus antigens in a sample. In particular, the invention relates to determining the concentration of influenza virus particles/influenza virus antigens in a sample. The invention further relates to the use of an ion-exchange matrix for the determination... Agent: Novartis Vaccines And Diagnostics Inc.

20090202984 - Single molecule nucleic acid sequence analysis processes and compositions: Improved solid supports and methods for analyzing target nucleotide sequences are provided herein. Certain improvements are directed to efficiently preparing nucleic acids that comprise nucleotide sequences identical to or substantially identical to one or more target nucleotide sequences, or complement thereof. The prepared nucleic acids include a reference sequence that... Agent: Grant Anderson LLP C/o Portfolioip

20090202999 - method for dna breakpoint analysis: The present invention relates to a method for identifying a DNA breakpoint and agents for use therein. More particularly, the present invention provides a method for identifying a gene translocation breakpoint based on the application of a novel multiplex DNA amplification technique. The method of the present invention facilitates not... Agent: Knobbe Martens Olson & Bear LLP

20090203022 - Analysis: A method of analysing a sample includes providing a first part of the sample and a second part of the sample. A first analysis is conducted on the first part of the sample and the results of the first analysis are considered. A second analysis is conducted on the second... Agent: Merchant & Gould PC

20090203027 - Assays for detecting t2r76 taste modulatory compounds: Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods employing the same, and methods for altering taste perception via administration of a T2R76 modulator. These T22R76 polypeptides can be expressed alone or co-expressed with another T2R polypeptide, preferably... Agent: Hunton & Williams LLP Intellectual Property Department

20090203006 - Biological markers of chronic wound tissue and methods of using for criteria in surgical debridement: The present invention relates to methods for identifying tissue sites in a chronic wound that are suitable for debridement and whether debridement procedure has been successful using particular biological markers of the cells within the tissue sites of the chronic wounds.... Agent: Darby & Darby P.C.

20090203020 - Bovine polymorphisms and methods of predicting bovine traits: Methods of predicting the phenotype of a trait in a bovine subject are provided. The methods include obtaining information about polynucleotide sequences specifically regarding the identity of the nucleotides present at one or more identified single nucleotide polymorphisms and using this information to make predictions regarding the trait in the... Agent: Michael Best & Friedrich LLP

20090203025 - Branched and multi-chain nucleic acid switches for sensing and screening: Embodiments of the invention relate to a branched or multichain nucleic acid switch adapted to switch from a first conformation to a second conformation upon ligand binding. The switch includes a probe strand, P, which includes the ligand binding domain; a switching framework which includes a cover strand (C), and... Agent: Knobbe Martens Olson & Bear LLP

20090202987 - Canis sphingosine 1-phosphate receptor isoform 2: A Canis sphingosine-1-phosphate (S1P) receptor isoform 2 (cS1P2), the nucleic acid encoding the cS1P2 receptor, and methods for using the S1P2 receptor and the nucleic acid encoding the cS1P2 receptor in assays for identifying analytes that modulate activity of the cS1P2 receptor. The assays can identify analytes that are useful... Agent: Merck And Co., Inc

20090202997 - Cell-free in vitro transcription and translation of membrane proteins into tethered planar lipid layers: The present invention relates to synthetic membranes having membrane proteins incorporated therein and, in particular, to the cell-free in vitro transcription and translation of membrane proteins into tethered planar lipid layers. In particular, the present invention provides a new method for the preparation of such membranes. The membranes, e.g., can... Agent: Morris Manning Martin LLP

20090203001 - Compositions and methods for diagnosing and treating macular degeneration: The present invention relates generally to biomarkers for macular degeneration. In particular, the present invention provides a plurality of biomarkers (e.g., polymorphisms and/or haplotypes) for monitoring and diagnosing macular degeneration. The compositions and methods of the present invention find use in diagnostic, therapeutic, research, and drug screening applications.... Agent: Casimir Jones, S.c.

20090203023 - Concentrating microorganisms in aqueous solution prior to selective staining and detection: Apparatus and methods for detecting a small number of target microorganisms found in a large volume of aqueous solution by diverting small volumes containing fluorescent microorganisms, including target microorganisms, into a smaller specimen of solution, followed by selectively staining the specimen to tag the target microorganisms and detecting the tagged... Agent: Jennifer L. Bales

20090203021 - Detection of clostridium difficile: The invention provides methods to detect C. difficile in biological samples using real-time PCR. Primers and probes for the detection of C. difficile are provided by the invention. Articles of manufacture containing such primers and probes for detecting C. difficile are further provided by the invention.... Agent: Fish & Richardson P.C.

20090203013 - Detection of methicillin-resistant staphylococcus aureus: The present invention provides improved tests for the detection of methicillin-resistant Staphylococcus aureus. The tests are particularly useful for eliminating false positive results due to the presence of a mixed bacterial population in patient samples.... Agent: Myers Bigel Sibley & Sajovec

20090203000 - Detection of nucleic acids using a cantilever sensor: Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The sensor is prepared by immobilizing a probe material to a surface of the sensor, wherein the probe... Agent: Woodcock Washburn LLP

20090202989 - Egfr and kras mutations: The present invention relates to mutations in Epidermal Growth Factor Receptor (EGFR) and KRAS and methods of detecting such mutations as well as prognostic methods method for identifying a tumors that are susceptible to anticancer therapy such as chemotherapy and/or kinase inhibitor treatment. The methods involve determining the presence of... Agent: Jones Day

20090202996 - Genetic polymorphisms for identifying individuals at risk for drug-induced vestibular dysfunction: In this application is described the identification of genetic variants that contribute to susceptibility to drug-induced vestibular dysfunction, more particularly, GM-induced vestibular dysfunction. Methods, compositions and kits for determining whether an individual has susceptibility for drug-induced vestibular dysfunction are disclosed.... Agent: Sana A. Pratt, Ph.d. Pratt & Associates, Inc.

20090202994 - Human single nucleotide polymorphisms in ion channels and other proteins: The invention provides polynucleotide fragments corresponding to the genomic and/or coding regions of these genes which comprise at least one polymorphic site per fragment. Allele-specific primers and probes that hybridize to these regions, and/or that comprise at least one polymorphic site are also provided. The polynucleotides, primers, and probes of... Agent: Louis J. Wille Bristol-myers Squibb Company

20090203003 - Inhibition of metallo-beta-lactamase: A method to identify a high affinity nucleic acid ligand to inhibit the activity of a lactamase enzyme. The method comprises several steps that initially involve preparing a candidate mixture of nucleic acids. The candidate mixture of nucleic acids is then allowed to make contact with the lactamase enzyme under... Agent: Winstead PC

20090203002 - Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures: The present invention provides a method of selectively amplifying fetal DNA sequences from a mixed, fetal-maternal source. This method utilizes differential methylation to allow for the selective amplification of trophoblast/fetal specific sequences from DNA mixtures that contain a high proportion of non-trophoblast/fetal DNA. The invention also provides methods of using... Agent: Kenyon & Kenyon LLP

20090203012 - Metabolic syndrome genetics: A gene (and polymorphisms within it) was associated with multiple components of the metabolic syndrome. Methods of screening subjects to identify risk of metabolic syndrome and related conditions are described, as are methods of screening compounds to identify those that act on the gene product as a target for the... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B482

20090203014 - Method for diagnosing autism spectrum disorder: The present invention provides methods of diagnosing and/or predicting autism spectrum disorder comprising determining the presence of microdeletions and microduplications on chromosomes 15 and 16.... Agent: David S. Resnick

20090203007 - Method for obtaining and initiating amplification of a target nucleic acid sequence: The present invention relates to oligonucleotides useful for determining the presence of Mycobacterium tuberculosis complex organisms in a test sample. The oligonucleotides of the present invention may be incorporated into detection probes, helper probes, capture probes and amplification oligonucleotides, and used in various combinations thereof.... Agent: Gen Probe Incorporated

20090202998 - Method for the extraction of biomolecules from fixed tissues: The present invention relates to a method for treating a fixed biological sample, comprising the steps of the method: i) provision of a fixed biological sample, ii) contacting the fixed biological sample with an aqueous solution comprising at least one nucleophilic reagent, and iii) heating the biological sample contacted with... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20090203026 - Methods and compositions for targeting secretory lysosomes: This invention relates to methods and compositions for targeting proteins to secretory lysosomes. The invention further provides methods of use in drug screening assays, and methods of purifying secretory lysosomes.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20090203011 - Methods and nucleic acids for analyses of cell proliferative disorders: Particular aspects provide methods, nucleic acids and kits for detecting cell proliferative disorders. Preferred aspects provide genomic sequences, the methylation patterns of which have substantial utility for the improved detection of said disorders, providing for improved diagnosis and treatment of same in patients.... Agent: Davis Wright Tremaine, LLP/seattle

20090203031 - Methods for detecting and quantifying specific microorganisms: Methods and compositions are disclosed for confirming and quantifying the presence of a specific kind of microorganism in a sample of material. Hybridization and polymerase chain reaction (PCR) techniques are applied to identify the presence of the specific microorganism in cultures grown in most probable number and serial dilution methods,... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20090203030 - Methods for detecting and quantifying specific probiotic microorganisms in animal feed: Methods and compositions are disclosed for confirming and quantifying the presence of a specific probiotic microorganism in a sample of animal feed. Hybridization and polymerase chain reaction (PCR) techniques are applied to identify the presence of the specific probiotic microorganism in cultures grown in most probable number and serial dilution... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20090202990 - Methods for the selection of aptamers: The present invention generally relates to methods for selecting aptamers. More specifically, the invention provides methods for the selection of at least one aptamer for use in combination with another epitope binding agent such as another aptamer, an antibody, or a double stranded nucleic acid. The invention also encompasses methods... Agent: Polsinelli Shughart PC

20090203019 - Methods of monitoring metabolic pathways: The present invention provides methods and compositions for monitoring cofactors and metabolites of a metabolic pathway of interest. The subject compositions and methods are particularly suited for monitoring the mevalonate pathway in a variety of cells. The invention also provides fermentation methods for the production of isoprenoids.... Agent: Wilson Sonsini Goodrich & Rosati

20090202986 - Methods of optimizing antibody variable region binding affinity: The present invention provides optimized heteromeric variable region binding fragments and antibodies comprising optimized heteromeric variable region binding fragments. Preferably, the optimized heteromeric variable region binding fragments exhibit optimized activity compared to donor heteromeric variable regions and have unvaried human frameworks. The present invention also provides methods of making the... Agent: Eli Lilly & Company

20090202995 - Molecular cardiotoxicology modeling: The present invention includes methods of predicting cardiotoxicity of test agents and methods of generating cardiotoxicity prediction models using algorithms for analyzing quantitative gene expression information. The invention also includes microarrays, computer systems comprising the toxicity prediction models, as well as methods of using the computer systems by remote users... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090203010 - Msmb-gene based diagnosis, staging and prognosis of prostate cancer: This invention relates generally to a method of diagnosis for distinguishing between a benign prostate hyperplasia and a prostate cancer and between a hormone-sensitive and a hormone-refractory prostate cancer condition and specifically to identification of a hypermethylated (on CpG and non-CpG dinucleotides) CpG island in the beta-microseminoprotein (MSMB) regulatory regions... Agent: Traskbritt, P.C.

20090203015 - Multiplex assays for hormonal and growth factor receptors, and uses thereof: The present invention provides compositions and methods for simultaneously detecting mRNA expression levels of hormonal receptors, particularly both estrogen receptor (ER) and progesterone receptor (PR), optionally in combination with growth factor receptors, particularly epidermal growth factor receptor ERBB2 (Her-2), and further optionally in combination with control genes, such as the... Agent: Celera Corporation

20090203004 - Non-thiopurine methyltransferase related effects in 6-mercaptopurine therapy: The present invention provides methods for predicting tolerance associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. In particular, the present invention provides methods for predicting a patient's risk of an adverse drug reaction (or tolerance) to a 6-mercaptopurine drug by genotyping a patient... Agent: Townsend And Townsend And Crew, LLP

20090203028 - Novel aptamers that bind to listeria surface proteins: Aptamers bind to Listeria surface proteins. A method of assaying a sample for the presence of Listeria monocytogenes includes exposing the sample to an aptamer that specifically binds one of the following proteins: Listeria monocytogenes internalin A protein, Listeria monocytogenes internalin E protein, and Listeria monocytogenes 0610 protein. The presence... Agent: Knobbe Martens Olson & Bear LLP

20090202991 - Novel diagnostic markers, especially for in vivo imaging and assays and methods of use thereof: Novel splice variants as diagnostic markers, preferably membrane-bound. The novel variants according to the present invention may optionally be used for diagnosis of Marker-detectable disease as described herein, optionally through immunohistochemistry.... Agent: Winston & Strawn LLP Patent Department

20090203009 - Novel method for high-throughput integrated chemical and biochemical reactions: The present invention relates to methods for monitoring in a high through-put fashion a multitude of molecular reaction processes, using a substrate, said substrate comprising a plurality of micro-channels, wherein each micro-channel has inlet and outlet open ends on opposing sides of said substrate, and wherein said micro-channels comprise at... Agent: Amster, Rothstein & Ebenstein LLP

20090203005 - Novel method of designing dna probe chip for room temperature hybridization and the dna probe chip: The present invention relates to a method of designing DNA probe chip for room-temperature hybridization in order to solve the solvent evaporation problem occurring when carrying out said hybridization at a high temperature of 40° C.˜50° C. or higher, wherein the method is designed to allow genotyping through hybridizing at... Agent: Blakely Sokoloff Taylor & Zafman LLP

20090203029 - Nucleic acid analysis using non-templated nucleotide addition: One embodiment of the invention is a method of producing an oligonucleotide extended by a single nucleotide base. An oligonucleotide and an extension terminating nucleotide are mixed with an enzyme having terminal transferase activity. The reaction produces an oligonucleotide extended by a single base. The extended oligonucleotide may be used... Agent: Life Technologies Corporation C/o Intellevate

20090203016 - Nucleic acid and corresponding protein entitled 85p1b3 useful in treatment and detection of cancer: A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic and/or therapeutic target for cancers. The 85P1B3 gene or fragment thereof,... Agent: Agensys C/o Morrison & Foerster LLP

20090203018 - Nucleic acid detection assays employing blocker oligonucleotides: The present invention provides methods, compositions, and kits for detecting the presence or absence of target sequences in a sample, where the sample also contains interfering sequences that are similar or identical to the target sequences. In particular, the present invention provides blocker oligonucleotides that at least partially inhibit the... Agent: Casimir Jones, S.c.

20090202992 - Polynucleotide and protein involved in synaptogenesis, variants thereof, and their therapeutic and diagnostic uses: The invention relates to a kit for diagnosing autism linked to a mutation in a protein belonging to the family of human neuroligins.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090203008 - Rapid method to determine inhibitor sensitivity of ns3/4a protease sequences cloned from clinical samples: A method for measuring HCV NS3/4A activity from a HCV NS3/4A sequence, comprising obtaining and cloning the sequence into a mammalian expression vector, transiently transfecting a mammalian cell with the vector, which includes a reporter construct encoding a HCV NS3/4A cleavage site fused to a detectable label, measuring signal production... Agent: Merck And Co., Inc

20090203024 - Secreted protein called 36p6d5 characteristic of tumors: Described is a gene and its encoded secreted tumor antigen, termed 36P6D5, and to diagnostic and therapeutic methods and compositions useful in the management of various cancers which express 36P6D5, particularly including cancers of the bladder, kidney, prostate, breast, colon, ovary, and pancreas.... Agent: Agensys C/o Morrison & Foerster LLP

20090203032 - Species-specific primer sets and identification of species-specific dna sequences using genome fragment enrichment: Targeted sequencing of genetic regions that differ between two DNA preparations uses genomic fragment enrichment. This method can be used to study genetic variation among closely related species and microbial communities, particularly for identifying sources of fecal pollution.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090203033 - Test and model for alzheimer's disease: The invention provides an isolated nucleic acid characteristic of human amyloid precursor protein 770 including the nucleotides encoding codon 670 and 671, wherein the nucleic acid encodes an amino acid other than lysine at codon 670 and/or an amino acid other than methionine at codon 671. Also provided is a... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20090202988 - Trap vectors and gene trapping using the same: A trap vector containing a loxP sequence composed of inverted repeat sequence 1, a spacer sequence and inverted repeat sequence 2 in this order, the loxP sequence being a mutant loxP wherein a part of the inverted repeat sequence 1 or 2 is mutated.... Agent: Birch Stewart Kolasch & Birch

20090202993 - Use of dna polymerases: Use of a DNA polymerase enzyme as a single stranded RNA exoribonuclease.... Agent: Crowell & Moring LLP Intellectual Property Group

20090203017 - Use of nucleic acid probes to detect nucleotide sequences of interest in a sample: The invention relates to methods for the determination and detection of nucleic acids sequences in a sample. The nucleic acid may be RNA or DNA or both. The invention also relates to methods for the determination of the presence and species of various microorganisms in a sample. We have also... Agent: Loeb & Loeb, LLP

20090203037 - Anti-t. cruzi antibodies and methods of use: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.... Agent: Paul D. Yasger Abbott Laboratories

20090203036 - Epitope regions of a thyrotrophin (tsh) receptor, uses thereof and antibodies thereto: The present invention is concerned with epitope regions of a thyrotrophin (TSH) receptor, uses thereof and antibodies thereto.... Agent: Merchant & Gould PC

20090203035 - Fluorescent proteins with increased photostability: The present invention relates to novel fluorescent protein variants of DsRed and eqFP578. Fluorescent protein variants having increased photostability and/or having reversible photoswitching behavior, as well as polynucleotides encoding such variants are provided herein. Methods of using these novel fluorescent protein variants and methods for constructing other fluorescent protein variants... Agent: Townsend And Townsend And Crew, LLP

20090203039 - Monoclonal antibody to soluble lox-1: It is intended to provide a monoclonal antibody that specifically recognizes human soluble LOX-1, particularly a monoclonal antibody with a dissociation constant (Kd) for human soluble LOX-1 of 1×10−9 (M) or less. The antibody can be produced from a hybridoma prepared by a method including the following steps of: (1)... Agent: Merchant & Gould PC

20090203038 - Negative mimic antibody for use as a blocking reagent in bnp immunoassays: The present disclosure relates to isolated antibodies that do not bind to brain natriuretic peptide that can be used as a reagent to reduce heterophilic interference in an immunoassay.... Agent: Paul D. Yasger Abbott Laboratories

20090203034 - Reagents for the detection of tyrosine phosphorylation in brain ischemia signaling pathways: The invention discloses 99 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Brain Ischemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20090203041 - Bmp4 inhibitors: A fragment of Gremlin having the sequence of amino acids shown in SEQ ID NO:2 or a functional subsequence of the fragment is described. The fragment is capable of altering BMP4 activity. Also provided is a polynucleotide encoding the fragment. Also disclosed is an assay for testing a molecule for... Agent: Michael Best & Friedrich LLP

20090203040 - Detection of specific nitrated markers: Methods are described for improving the diagnostic possibilities of diseases where oxidative NO-modifications occur, for example inflammatory conditions, cancer, Parkinson's or Alzheimer's disease, and to provide means of monitoring the effects of therapeutical measures taken towards such diseases. The invention enables the detection of disease specific catabolic markers related to... Agent: Jacobson Holman PLLC

20090203042 - Novel bt toxin receptors from lepidopteran insects and methods of use: The invention relates to Bt toxin resistance management. The invention particularly relates to the isolation and characterization of nucleic acid and polypeptides for a novel Bt toxin receptor. The nucleic acid and polypeptides are useful in identifying and designing novel Bt toxin receptor ligands including novel insecticidal toxins.... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20090203047 - 88kda tumorigenic growth factor and antagonists: This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expression or action. Antagonists to an 88 KDa autocrine growth and tumorigenicity stimulator are provided which inhibit its expression or biological activity. The antagonists include antisense oligonucleotides and... Agent: Womble Carlyle Sandridge & Rice, PLLC

20090203049 - Beta integrin gene and protein: Recombinant materials for the production of β integrin protein characteristic of Manduca sexta are useful for screening pesticides for this moth.... Agent: Morrison & Foerster LLP

20090203046 - Methods for identifying purkinje cells using the corl2 gene as a target: Total RNAs were prepared from the ventral and dorsal regions of embryonic day 12.5 mouse mesencephalon, and a cDNA fragment was obtained by the subtraction method (N-RDA). The full-length cDNA was cloned and the nucleotide sequence was determined. The gene was named Corl2. The result of homology search showed that... Agent: Townsend And Townsend And Crew, LLP

20090203048 - Screening assays for antioxidants and antiproliferative compounds: Provided are screening assays for identifying and evaluating compounds with antioxidant and/or antiproliferative activities.... Agent: Fish & Richardson PC

20090203050 - Molecular signaling pathways triggered by rituximab: prognostic, diagnostic, and therapeutic uses: The present invention provides markers associated with activated molecular signaling pathways (example: p38 MAKP, NF-κB, ERK1/2, YY-1 and AKT) inhibited by rituximab in cancer cells as well as pathways activated by rituximab (such as death receptors, RKIP, PTEN) all of which are associated with the regulation of chemo and immunoresistance.... Agent: Townsend And Townsend And Crew, LLP

20090203051 - Targets in breast cancer for prognosis or therapy: Cancer markers are developed to detect diseases characterized by increased expression of apoptosis-suppressing genes, such as aggressive cancers. Genome wide analyses of genome copy number and gene expression in breast cancer revealed 66 genes in the human chromosomal regions, 8p11, 11q13, 17q12, and 20q13 that were amplified. Diagnosis and assessment... Agent: Townsend And Townsend And Crew, LLP

20090203052 - Novel soluble cd14 antigen: n

20090203043 - Protein phosphorylation by basophilic serine/threonine kinases in insulin signaling pathways: The invention discloses 142 novel phosphorylation sites identified in insulin signaling pathways, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20090203044 - Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor: Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicted with cancer. Diagnostic methods and kits may employ an agent suitable for detecting alterations... Agent: Seed Intellectual Property Law Group PLLC

20090203045 - Crystal structure of soluble glutaminyl cyclase: A crystalline structure of glutaminyl cyclase (QC) is described. Also described are the methods of preparing the crystalline structure of QC and the methods for identifying candidate inhibitors of QC. In addition, a structural basis for the rational design or identification of new inhibitors that may be used to treat... Agent: Panitch Schwarze Belisario & Nadel LLP

20090203053 - Methods and materials for amplification of a signal in an immunoassay: Ultrafine particles are provided having a core region that has a signal amplifying molecule and a shell region that surrounds the core region. The shell region has at least one antibody affixed to its surface that is specific for at least one antigen. Alternatively, the ultrafine particles may entrap the... Agent: K&l Gates LLP

20090203054 - Hdl cholesterol sensor using selective surfactant: A method for the determination of the amount of cholesterol in high density lipoproteins in a high density lipoprotein containing sample, said method comprising reacting the sample with a surfactant which selectively reacts with high density lipoproteins in the sample, said surfactant being selected from sucrose esters, and maltosides, and... Agent: Quarles & Brady LLP

20090203055 - Compositions and methods for rna interference with sialidase expression and uses thereof: The present invention provides RNAi agents targeted to sialidase. The RNAi agents include siRNA, shRNA, and expression vectors that comprise a template for transcription of an siRNA or shRNA. The invention further provides cells and cell lines that comprise an RNAi agent targeted to sialidase. The cells and cell lines... Agent: Choate, Hall & Stewart LLP

20090203056 - Kit for diagnosis of cancer: The present invention relates to a kit for assaying the activity of the human arylsulphatase or its isozymes, including 4-MUS and 4-MU. The kit can be used for initial screening, therapeutic effect monitoring and recurrence inspecting of human cancers.... Agent: Wang & Ho

20090203057 - Protein demethylases comprising a jmjc domain: Post-translational modification, including protein methylation, plays an important role in regulating protein function. The present invention provides a novel assay for evaluating demethylase activity and the discovery of a family of protein demethylases comprising a novel demethylase motif.... Agent: Myers Bigel Sibley & Sajovec

20090203058 - Method for determination of allergen in environment and kit for simple quantification of allergen: A simple method for measuring allergens is disclosed, by which the amount of environmental allergens can be measured simply without using an anti-allergen antibody. In the method for measuring an environmental biological allergen(s), a solution containing a substrate of a protease which the allergen(s) has (have) is brought into contact... Agent: Birch Stewart Kolasch & Birch

20090203059 - Protease detection product: A protease detection product (1) for detecting a protease enzyme in a sample. The protease detection product (1) comprises a medium (2) providing a liquid flow path; a labelled component (6) located on the liquid flow path; a capture component (12) located downstream of the labelled component (6) and immobilisation... Agent: Clark & Elbing LLP

20090203060 - Evaluating mmp expression in patient stratification and other therapeutic, diagnostic and prognostic methods for cancer: Provided are compositions, methods and kits for quantifying the expression and/or activity of MMP-14 and other biomarkers of cancer, which may be used diagnostically and prognostically, e.g., in patient stratification and evaluation of appropriate therapeutic regimens.... Agent: Lando & Anastasi, LLP

20090203061 - Device and method for observing the organization of studied cells cultured in the presence of a concentration gradient of chemotactic molecules: The device comprises a cell culture compartment (10) and a diffusion compartment (20) in fluid communication with the cell culture compartment (20) through a filtering element (22) for the progressive diffusion of chemotactic molecules contained in the diffusion compartment into a culture medium contained in the culture compartment, so as... Agent: Stites & Harbison PLLC

20090203063 - Droplet-based cell culture and cell assays using digital microfluidics: We introduce a new method for implementing cell-based assays and long-term cell culture. The method is based on digital microfluidics (DMF) which is used to actuate nanoliter droplets of reagents and cells on a planar array of electrodes. DMF method is sutable for assaying and culturing both cells in suspension... Agent: Ralph A. Dowell Of Dowell & Dowell P.C.

20090203064 - Method and device for monitoring platelet function: The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in the passageway to generate a platelet mass in the passageway, and monitoring the flow or composition of the... Agent: Popovich, Wiles & O'connell, PA 650 Third Avenue South

20090203062 - Method for identifying and/or quantifying anti-infective compounds: The present invention relates to a method for identifying and/or quantifying an anti-infective compound. Furthermore it relates to a method for identifying and/or quantifying a mutation in a virulence factor of a pathogen of a host organism that reduces the virulence of the pathogen to a unicellular test organism.... Agent: Swanson & Bratschun, L.L.C.

20090203065 - Cell culture article and screening: A method for producing a cell culture article having a synthetic polymer layer for incubating with cells includes diluting one or more (meth)acrylate monomers in a solvent and dispersing the diluted monomers on a surface of the cell culture article. Some or substantially all of the solvent is removed and... Agent: Corning Incorporated

20090203066 - Method for preparing a sample: A method for preparing a sample consisting of biological tissue in a solid matrix includes steps of: contacting the sample with a first compressed fluid stream wherein the matrix is soluble so as to extract the solid matrix, contacting the sample with a second compressed fluid, adapted to impregnate the... Agent: Young & Thompson

20090203067 - Photobioreactor systems and methods for growing organisms: Photobioreactors and systems for growth of a photosynthetic organism are provided herein. The systems and photobioreactors can comprise features and modifications in order to improve photosynthetic growth efficiency and light energy utilization. Also provided are methods and systems to improve the cost-effectiveness of a photobioreactor system for growth of a... Agent: Wilson Sonsini Goodrich & Rosati

20090203068 - High pressure enzymatic digestion system for protein characterization: A method and system for obtaining samples for proteomic analysis that utilizes pressure and a preselected agent to obtain a processing sample in a significantly shorter period of time than prior art methods and which maintains the integrity of the processing sample through the preparatory process. In one embodiment of... Agent: Battelle Memorial Institute Attn:IPServices, K1-53

20090203074 - Bacillus host cell: A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more secreted polypeptide(s) which is at least 80% identical to one or more of the polypeptides shown in SEQ ID NO's: 2... Agent: Novozymes North America, Inc.

20090203072 - Detection for hpv-induced invasive cancers and their precursor lesions with invasive potential: This invention provides a method of detecting an HPV-induced invasive cancer or precursor lesion thereof associated with tumor suppressor lung cancer 1 (TSLC1) in a subject in need thereof. The method comprises contacting a cell component of a test cell of the subject with a reagent that detects the level... Agent: Cooper & Dunham, LLP

20090203071 - Expression in insect cells of genes with overlapping open reading frames, methods and compositions therefor: The present teachings disclose nucleic acid cassettes for expressing in an insect cell a plurality of polypeptides encoded by a gene comprising overlapping open reading frames (ORFs). A cassette comprises, in 5′ to 3′ order, a) a first insect cell-operable promoter, b) a 5′ portion of a gene comprising a... Agent: Sonnenschein Nath & Rosenthal LLP

20090203073 - Gene encoding g-protein coupled receptor and gene product thereof: The present invention, the objects of which are to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein, and to provide a useful... Agent: Kilyk & Bowersox, P.l.l.c.

20090203075 - Genes conferring herbicide resistance: Compositions and methods for conferring herbicide resistance to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a polypeptide that confers resistance or tolerance to glyphosate herbicides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and... Agent: Alston & Bird LLP

20090203070 - Hyperphotosynthetic organisms: The present disclosure identifies pathways and mechanisms to confer improved industrial fitness on engineered organisms. It also discloses engineered organisms having improved industrial fitness. Synthetic biologic engineering modules are disclosed that provide for light capture, carbon dioxide fixation, NADH production, NADPH production, thermotolerance, pH tolerance, flue gas tolerance, salt tolerance,... Agent: Fenwick & West LLP

20090203069 - Organic compounds: Disclosed is a method for the production of a heterologous polypeptide of interest with a homogenous N-terminus, using a fusion polypeptide comprising the polypeptide of interest and N-terminally thereto a polypeptide exhibiting autoproteolytic function, said method comprising the steps of a) binding of the fusion polypeptide in a soluble, autoproteolytically... Agent: Birch Stewart Kolasch & Birch

20090203076 - Compositions and methods for increasing protein production: Compositions and methods for increasing protein production are provided.... Agent: Dann, Dorfman, Herrell & Skillman

20090203077 - Method of producing factor viii proteins by recombinant methods: Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked to a promoter, wherein the promoter is characterized by the ability to produce commercially viable Factor VIII protein; and incubating the... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20090203078 - Process for producing polypeptide: The present invention relates to a process for producing a desired polypeptide using rat cells. Specifically, the present invention relates to a process for producing the polypeptide which comprises culturing rat cells such as YB2/3HL.P2.G11.16Ag.20 (hereinafter referred to as YB2/0), preferably rat cells to which a recombinant DNA comprising DNA... Agent: Sughrue-265550

20090203079 - Transgenic monocot plants encoding beta-glucosidase and xylanase: Plant proteins isolated from monocot plants from transformation of the monocot plant with DNA at least 80% homologous to the bglA gene encoding β-glucosidase from a rumen bacterium which is Butyrivibrio fibrisolvens H17c and targeted to a subcellular compartment. The transformed plant is ground after the β-glucosidase has been accumulated,... Agent: Ian C. Mcleod Ian C. Mcleod, P.C.

20090203080 - S-adenosylmethionine synthetase mutants, the dnas encoding the same and uses of the mutants: The invention discloses a series of Methanococcus jannaschii S-adenosylmethionine synthetase mutants with improved thermostability and high catalytic activity obtained by using gene mutation technique, characterized in that these mutants refer to an enzyme using Sequence 2 in the Sequence Listing as the reference sequence and contains at least one mutation... Agent: The Webb Law Firm, P.C.

20090203081 - Inducible expression vectors and methods of use thereof: The present invention provides nucleic acids that include a promoter that is inducible by a transcriptional activator protein; and a nucleotide sequence that encodes the transcriptional activator protein. The present invention provides expression vectors that provide for inducible production of gene products in a host cell. The present invention further... Agent: Uc Berkeley - Otl Bozicevic, Field & Francis LLP

20090203085 - Isothermal nucleic acid amplification methods and compositions: Methods and compositions are provided related to the amplification of target polynucleotide sequences as well as total RNA and total DNA amplification. In some embodiments, the methods and compositions also allow for the immobilization and capture of target polynucleotides with defined 3′ and or 5′ sequences to solid surfaces. The... Agent: Wilson Sonsini Goodrich & Rosati

20090203084 - Methods and apparatuses for convective polymerase chain reaction (pcr): The present invention provides a method and apparatus for amplifying a nucleic acid sequence by polymerase chain reaction (PCR). The method comprises placing a PCR sample in a container which is heated by only a single heat source that provides a high temperature for denaturation in the bottom of the... Agent: Occhiuti Rohlicek & Tsao, LLP

20090203083 - Substrate for nucleic acid amplification: The present invention relates to a method, a substrate, a kit, and a system for nucleic acid amplification comprising a porous substrate with pores enabling the diffusion of biomolecules. More particular, the present invention relates to a method, a substrate, a kit and a system, wherein the nucleic acid amplification... Agent: Roche Diagnostics Operations Inc.

20090203082 - Thermocycling of a block comprising multiple sample: The present invention relates to the field of high throughput analysis of samples. In particular, the present invention is directed to a device, a System and a method for simultaneous tempering of multiple samples. More particular, the invention relates to the simultaneous thermocycling of multiple samples to perform PCR in... Agent: Dinsmore & Shohl, LLP One Dayton Centre

20090203086 - System and method for improved signal detection in nucleic acid sequencing: An embodiment of a system for reducing crosstalk in a parallel sequencing platform is described that comprises a substrate with a plurality of individual reaction environments that include a species of nucleic acid template, and a plurality of spatially localized reactants, wherein the localized reactants minimize the transmission of reaction... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090203087 - Expression of granular starch hydrolyzing enzymes in trichoderma and process for producing glucose from granular starch substrates: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity (GSHE). Further the invention relates to a method for producing a glucose syrup comprising contacting a granular starch slurry obtained from a granular... Agent: Danisco US Inc. Attention: Legal Department

20090203088 - Heterologous alpha amylase expression in aspergillus: The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same.... Agent: Danisco US Inc. Attention: Legal Department

20090203089 - Isolated alcohol dehydrogenase enzymes and uses thereof: Bacterial polynucleotides and polypeptides are provided in which the polypeptides have a dehydrogenase activity, such as an alcohol dehydrogenase (ADH) activity, an uronate, a 4-deoxy-L-erythro-5-hexoseulose uronate (DEHU) ((4S,5S)-4,5 dihydroxy-2,6-dioxohexanoate) hydrogenase activity, a 2-keto-3-deoxy-D-gluconate dehydrogenase activity, a D-mannuronate hydrogenase activity, and/or a D-mannnonate dehydrogenase activity. Methods, enzymes, recombinant microorganism, and microbial... Agent: Seed Intellectual Property Law Group PLLC

20090203090 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family: A method for producing an L-amino acid is described, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine, L-tryptophan, or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of a wild-type alcohol dehydrogenase encoded by the adhE gene or a mutant... Agent: Cermak & Kenealy LLP Acs LLC

20090203091 - Mutants for the preparation of d-amino acids: The present invention relates to specific Escherichia. coli mutants which can be used for the synthesis of D-amino acids, and to such a process. The mutants are distinguished by deficiencies in particular enzymes which break down D-amino acids and include those which produce D-amino acids via the carbamoylase/hydantoinase route.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090203092 - Liquid biofuel mixture and method and device for producing the same: e

20090203093 - Protein targeting to lipid bodies: The present invention relates to a method of targeting a protein of interest to an intracellular hydrophobic inclusion body of a bacterial cell by means of a fusion protein comprising a hydrophobic targeting peptide operatively linked with said protein of interest; methods of microbial production of a lipophilic compound of... Agent: Connolly Bove Lodge & Hutz, LLP

20090203094 - Use of genes for increasing the oil content in plants: The invention relates to methods for increasing the oil content in plants, preferably in plant seeds, by expressing the Ypr140w polypeptide from yeast or corresponding polypeptides from plants. The invention furthermore relates to expression constructs for expressing the yeast polypeptide Ypr140w or corresponding polypeptides from plants in plants, preferably in... Agent: Connolly Bove Lodge & Hutz, LLP

20090203095 - Novel engineered microorganism producing homo-succinic acid and method for preparing succinic acid using the same: The present invention relates to a mutant microorganism, which is selected from the group consisting of genus Mannheimia, genus Actinobacillus and genus Anaerobiospirillum, producing homo-succinic acid and a method for producing homo-succinic acid using the same, and more particularly to a mutant microorganism producing succinic acid at a high concentration... Agent: Moore & Van Allen PLLC

20090203096 - Process for production of optically active alcohol: The present invention provides methods for producing (S)-1,1,1-trifluoro-2-propanol, which include the step of reacting an enzyme of any one of alcohol dehydrogenase CpSADH, alcohol dehydrogenase ReSADH, carbonyl reductase ScoPAR, (2S,3S)-butanediol dehydrogenase ZraSBDH, carbonyl reductase ScGCY1, tropinone reductase HnTR1, tropinone reductase DsTR1, or alcohol dehydrogenase BstADHT, a microorganism or a transformant... Agent: Foley And Lardner LLP Suite 500

20090203098 - Indirect production of butanol and hexanol: A process for the conversion of carbohydrates from any of a number of sources into butanol and hexanol for fuel or chemical use is disclosed. The process includes conducting a homoacetogenic fermentation to produce an acetic acid intermediate which is chemically converted to ethanol. The ethanol and a remaining portion... Agent: Sheridan Ross PC

20090203097 - Strain for butanol production: Screening of fatty acid fed bacteria which are not natural butanol producers identified increased membrane cyclopropane fatty acid as providing improved butanol tolerance. Increasing expression of cyclopropane fatty acid synthase in the presence of the enzyme substrate that is either endogenous to the cell or fed to the cell, increased... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090203100 - Microbial fermentation of gaseous substrates to produce alcohols: The present invention relates to methods for increasing the efficiency of anaerobic fermentation processes (1) that produce acetate as a by-product in addition to a desired product, and (2) that can utilise hydrogen and/or carbon dioxide in the fermentation. The method comprises the steps of converting acetate produced by the... Agent: Occhiuti Rohlicek & Tsao, LLP

20090203099 - Zymomonas with improved ethanol production in medium containing concentrated sugars and acetate: Through screening of a Zymomonas mutant library the himA gene was found to be involved in the inhibitory effect of acetate on Zymomonas performance. Xylose-utilizing Zymomonas strains further engineered to reduce activity of the himA gene were found to have increased ethanol production in comparison to a parental strain, when... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090203101 - Enzyme blends for fermentation: The present invention relates to an enzyme blend composition comprising a glucoamylase, an acid stable alpha amylase, and an acid fungal protease. The present invention is further directed to a method for producing end products such as alcohols from fermentable sugars, comprising the steps of: (a) contacting a slurry comprising... Agent: Danisco US Inc., Genencor Division

20090203102 - Compositions and methods for producing isoprene: The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.... Agent: Morrison & Foerster LLP

20090203103 - Induction and stabilization of enzymatic activity in microorganisms: The present invention is directed to methods for inducing desired activity in enzymes or microorganisms capable of producing the enzymes. The invention is further directed to methods of stabilizing activity in microorganisms. In specific embodiments, the invention provides methods for inducing and stabilizing nitrile hydratase activity, amidase activity, and asparaginase... Agent: Fish & Richardson P.C.

20090203104 - Tab molecules: The present invention relates to TAB molecules, ADEPT constructs directed against TAG-72, and their use in therapy.... Agent: Elena E. Quertermous Genencor International, Inc

20090203105 - Ura5 gene and methods for stable genetic integration in yeast: A novel gene encoding P. pastoris orotate-phosphoribosyl transferase (URA5) is disclosed. Methods for producing and selecting yeast strains capable of stable genetic integration of heterologous sequences into the host genome are also provided.... Agent: Merck And Co., Inc

20090203106 - Galactanase variants: The present invention relates to variants of Glycoside Hydrolase family 53 galactanases, e.g., variants of the galactanases from strains of Yersinia, Aspergillus, Humicola, Meripilus, Myceliophthora, Thermomyces, Bacillus, Bifidobacterium, Cellvibrio, Clostridium, Pseudomonas, Thermotoga, or Xanthomonas.... Agent: Novozymes North America, Inc.

20090203109 - Alpha-amylase variants: The invention relates to a variant of a parent Termamyl-like α-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased stability at high temperatures (relative to the parent). The invention also relates to a DNA construct comprising a DNA sequence encoding an α-amylase variant of... Agent: Novozymes North America, Inc.

20090203108 - Method for preparing maltogenic alpha-amylase variants: The inventors have modified the amino acid sequence of a maltogenic alpha-amylase to obtain variants with improved properties, based on the three-dimensional structure of the maltogenic alpha-amylase Novamyl. The variants have altered physicochemical properties., e.g. an altered pH optimum, improved thermostability, increased specific activity, an altered cleavage pattern or an... Agent: Novozymes North America, Inc.

20090203107 - Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of at least partially degrading, cleaving, or removing polysaccharides, lignocellulose, cellulose, hemicellulose, lignin, starch, chitin, polyhydroxybutyrate, heteroxylans, glycosides, xylan-, glucan-, galactan, or mannan-decorating groups using isolated and/or purified polypeptides and nucleic... Agent: Traskbritt / Battelle Energy Alliance, LLC

20090203110 - Composition exhibiting a von willebrand factor (vwf) protease activity comprising a polypeptide chain with the amino acid sequence aaggilhlellv: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.... Agent: Baxter Healthcare Corporation

20090203111 - Subtilases: The present invention relates to methods for producing variants of a parent JP170 subtilase and of a parent BPN′ subtilase and to JP170 and BPN′ variants having altered properties as compared to the parent JP170/BPN′ subtilase.... Agent: Novozymes North America, Inc.

20090203113 - Chimeric papillomavirus-like particles: The present invention provides a papillomavirus-like particle, characterized as having conformational epitopes, comprising a papillomavirus L1 product and a papillomavirus L2 fusion product; and related synthetic DNA molecules, host cells, methods and vaccines.... Agent: Knobbe, Martens, Olson & Bear, LLP

20090203114 - Novel methods and interferon deficient substrates for the propagation of viruses: The present invention relates, to novel methods and substrates for the propagation of viruses. The invention relates to IFN-deficient substrates and methods for propagating viruses in these unconventional substrates. In particular, the invention relates to methods of propagating viruses in immature embryonated eggs, preferably six- to nine-day-old chicken eggs. The... Agent: Jones Day

20090203112 - Vero cell line which is adapted to grow in suspension: The invention relates to a Vero cell line that can be grown in serum-free and protein-free culture and in suspension culture in the absence of carrier for its adherence, and to production of viral vaccines using said cell line. More particularly, the present invention relates to establishment of a cell... Agent: Ratnerprestia

20090203115 - Hydroponic growing enclosure and method for growing, harvesting, processing and distributing algae, related microrganisms and their by products: Systems and methods for hydroponically growing microorganisms within a self-contained air-supported structure, in which microorganisms are grown in an organic slurry, harvested, and processed to obtain and process and distribute molecules useful for biofuel or other purposes.... Agent: Lewis, Rice & Fingersh, Lc Attn: BoxIPDept.

20090203116 - System to improve algae production in a photo-bioreactor: This invention provides a method of delivering light internally to a Photo-Bioreactor growing algae for production of Biodiesel fuel. The invention also provides an improved method of delivering liquid nutrients [I.e. sewage] and carbon dioxide to the growing algae in a Photo-Bioreactor. These results are achieved by a single system... Agent: Keith Bazaire

20090203117 - Apparatus for processing biological material: The present invention relates to an apparatus for processing biological materials, comprising a platform having a plurality of sample receiving areas located thereon, each sample receiving area being substantially enclosed in a holding means, the apparatus also having at least one liquid carrier member mounted for supplying liquid to and/or... Agent: John S Hale Gipple & Hale

20090203118 - Optical system including nanostructures for biological or chemical sensing: An analytical device is disclosed. In one embodiment, the analytical device includes a three-dimensional substrate structure comprising a three-dimensional surface. A plurality of noble metal nanoparticles are on the three-dimensional substrate structure. A plurality of capture agents are on the noble metal nanoparticles.... Agent: Townsend And Townsend And Crew, LLP

20090203119 - Biomass reactor: A reactor for the conversion of biomass material includes an elongate annular chamber with an inner wall and an outer casing. A screw conveyor extends from one end into the chamber to feed biomass material. A heat source is provided within the inner wall of the chamber, and may be... Agent: Charter Ip, LLC

20090203120 - Thermal cycling apparatus and method for providing thermal uniformity: An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a thermoelectric module. An edge heater can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling.... Agent: Life Technologies Corporation C/o Intellevate

20090203121 - Nucleic acid agents for downregulating h19, and methods of using same: Isolated oligonucleotides capable of down-regulating H19 mRNA in cancer cells are disclosed, as well as pharmaceutical compositions that include the oligonucleotides and methods of treatment of cancer using them. Methods of treating cancer comprising administering agents capable of downregulating H19 mRNA in combination with an additional anti-cancer treatment are further... Agent: Winston & Strawn LLP Patent Department

20090203126 - Cell culture array system for automated assays and methods of operation and manufacture thereof: A number of novel improved microfluidic configurations and systems and methods of manufacture and operation. In one embodiment, three wells are used for independent cell culture systems in a cell culture array. In a second aspect, artificial sinusoids with artificial epithelial barriers are provided with just one (optionally shared or... Agent: Quine Intellectual Property Law Group, P.C.

20090203123 - Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof: The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.... Agent: Fulbright & Jaworski, LLP

20090203124 - Mage-a3 peptides presented by hla-dr1 molecules: The invention describes HLA class II binding peptides encoded by the MAGE tumor associated genes, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized... Agent: Wolf Greenfield & Sacks, P.C.

20090203125 - Mig-7 as a specific anticancer target: Aspects of the present invention provide novel Mig-7 encoding nucleic acids and Mig-7 polypeptides, recombinant DNA expression systems and host cells containing same, as well as methods of inhibiting expression of the subject nucleic acid molecules, inhibiting production of the encoded proteins or polypeptides, inhibiting metastasis of a carcinoma cell... Agent: Seed Intellectual Property Law Group PLLC

20090203129 - Multipotent adult stem cells and methods for isolation: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.... Agent: Thompson Hine L.L.P. Intellectual Property Group

20090203130 - Multipotent adult stem cells and methods for isolation: The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.... Agent: Thompson Hine L.L.P. Intellectual Property Group

20090203127 - Nematode fatty acid desaturase-like sequences: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as arc vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid... Agent: Fish & Richardson PC

20090203128 - Nogo-receptors and methods of use: Disclosed are compositions relating to the Nogo receptor (NgR) family as well as fragments, chimeras, and variants thereof. The invention provides polypeptides, nucleic acids, vectors, expression systems, and antibodies and antibody fragments related to the NgRs as well as uses thereof. Such uses include modulation neurite outgrowth in a subject... Agent: Fish & Richardson P.C.

20090203122 - Peripheral nervous system specific sodium channels, dna encoding therefor, crystallization, x-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof: Cloning, expression, viral and delivery vectors and hosts which contain nucleic acid coding for at least one peripheral nervous system specific (PNS) sodium channel peptide (SCP), isolated PNS SCP, and compounds and compositions and methods, are provided, for isolating, crystallizing, x-ray analysing molecular modeling, rational drug designing, selecting, making and... Agent: Townsend And Townsend And Crew, LLP

20090203137 - Compounds for the modulation of beta-catenin expression: The invention relates to oligomer compounds (oligomers), which target beta-catenin mRNA in a cell, leading to reduced expression of beta-catenin. Reduction of beta-catenin expression is beneficial for a range of medical disorders, such as hyperproliferative disorders, such as cancer. The invention provides therapeutic compositions comprising oligomers and methods for modulating... Agent: Dechert LLP

20090203133 - Determinants of sensitivity to chemotherapeutic agents: The present invention provides methods for determining the level of resistance of a tumour cell to one or more chemotherapeutic agents, comprising measuring the level of expression of a muscle ankyrin repeat protein in the tumour cell. The invention also provides methods for increasing the sensitivity of a tumour cell... Agent: Seed Intellectual Property Law Group PLLC

20090203135 - Glycoconjugates of rna interference agents: The present invention relates to agents, compositions and methods for inhibiting the expression of a target gene, comprising an RNAi agent bearing at least one galactosyl moiety. These are useful for delivering the gene expression inhibiting activity to cells, particularly hepatocytes, and more particularly in therapeutic applications.... Agent: Nixon Peabody LLP

20090203136 - Modulating immune system development and function through microrna mir-146: The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments,... Agent: Knobbe Martens Olson & Bear LLP

20090203131 - Polyamides for nucleic acid delivery: The present invention describes reagents and methods for using concatermized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end copies of a short dsDNA containing a sequence or sequences that act as transcription factor decoys.... Agent: Dinsmore & Shohl LLP

20090203132 - Pyrrolidinyl groups for attaching conjugates to oligomeric compounds: The present invention provides pyrrolidinyl compounds that are useful for preparing conjugated oligomeric compounds. The conjugated pyrrolidinyl compounds can be attached to support medium and provide a free hydroxyl for oligomer synthesis to prepare an oligmeric compound having a 3′-conjugate. Alternatively, the pyrrolidinyl compound can be prepared as a phosphoramidite... Agent: Woodcock Washburn LLP

20090203134 - Remedy for nerve cell regeneration: Wnt3a proteins represented by SEQ ID NO:2, etc. are used as the active ingredient of remedy for nerve cell regeneration, in particular, remedy for retinal cell regeneration which is useful in treating retinitis pigmentosa, age-related macular degeneration, cone dystrophy and so on.... Agent: Knobbe Martens Olson & Bear LLP

20090203138 - Small interfering rnas targeting feline herpes virus: The present application provides polynucleotides, compositions thereof and methods of treating feline herpes virus infections. In certain embodiments, the polynucleotides and compositions thereof can be used to reduce replication of feline herpes simplex virus 1 (FHV-1) in vivo and/or in vitro.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090203139 - Production of four carbon alcohols using improved strain: Using screening of transposon random insertion mutants, genes involved in accumulation of (p)ppGpp were found to be involved in bacterial cell response to butanol. Reduced production of proteins with enzymatic activity for (p)ppGpp biosynthesis confers increased butanol tolerance. Bacterial strains with reduced (p)ppGpp accumulation and having a butanol or 2-butanone... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090203140 - Genomic editing in zebrafish using zinc finger nucleases: Disclosed herein are methods and compositions for genomic editing of one or more genes in zebrafish, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.... Agent: Robins & Pasternak

20090203141 - Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant rna agents: The present invention generally relates to a method for developing, generating and selecting tumor-free embryonic stem (ES)-like pluripotent cells using electroporation delivery of an inducible tumor suppressor mir-302 agent into mammalian cells. More particularly, the present invention relates to a method and composition for generating a Tet-On/Off recombinant transgene capable... Agent: Birch Stewart Kolasch & Birch

20090203142 - Nucleotide sequences of a new class of diverged delta-9 stearoyl-acp desaturase genes: An isolated nucleic acid fragment encoding a diverged delta-9 fatty acid desaturase is disclosed. Also the construction of a chimeric gene encoding all or a portion of the diverged delta-9 fatty acid desaturase is disclosed, in sense or antisense orientation, wherein expression of the chimeric gene results in production of... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090203143 - Trans-splicing mediated photodynamic therapy: The present invention provides methods and compositions for conferring selective death on cells expressing a specific target precursor messenger RNA (selective target pre-mRNA). The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) expressed within a cell and mediate... Agent: Saul Ewing LLP (baltimore) Attn: Patent Docket Clerk

20090203144 - Hiv-gag codon-optimised dna vaccines: The invention provides a nucleotide sequence that encodes an HIV-1 gag protein or fragment thereof containing a gag epitope and a second HIV antigen or a fragment encoding an epitope of said second HIV antigen, operably linked to a heterologous promoter. Preferred polynucleotide sequences further encodes nef or a fragment... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

  
08/06/2009 > patent applications in patent subcategories. inventions list

20090197240 - Systems and methods for ex vivo lung care: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through... Agent: Wilmerhale/dc

20090197241 - Systems and methods for ex vivo lung care: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through... Agent: Wilmerhale/dc

20090197242 - Lipidomic approaches to determining drug response phenotypes in cardiovascular disease: The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a statin treatment regimen by obtaining a lipid profile of a sample... Agent: Myers Bigel Sibley & Sajovec

20090197243 - Method and composition for rapid viability testing of cells: The present invention relates to a method for rapidly monitoring a stress response of a cell to a stressor and determining the magnitude of the stress response; a method for rapidly detecting the presence or absence of a cell by monitoring a stress response of the cell if said cell... Agent: Arendt & Associates Intellectual Property Group

20090197244 - Method for typing and detecting hbv: The present invention relates to a method for detection and/or genetic analysis of HBV in a biological sample, comprising hybridizing the polynucleic acids of the sample with a combination of at least two nucleotide probes, with said combination hybridizing specifically to a mutant target sequence chosen from the HBV RT... Agent: Nixon & Vanderhye, PC

20090197245 - Rapid detection of dengue virus: One example of a solution provided here comprises providing a single-stranded oligonucleotide, the oligonucleotide being complementary to a portion of SEQ ID NO:1, and contacting the oligonucleotide with a nucleic acid comprising the sequence of SEQ ID NO:1, under conditions that permit hybridization of the oligonucleotide with the nucleic acid.... Agent: Department Of The Air Force

20090197261 - Aptamer- and nucleic acid enzyme-based systems for simultaneous detection of multiple analytes: The present invention provides aptamer- and nucleic acid enzyme-based systems for simultaneously determining the presence and optionally the concentration of multiple analytes in a sample. Methods of utilizing the system and kits that include the sensor components are also provided. The system includes a first reactive polynucleotide that reacts to... Agent: Evan Law Group LLC

20090197274 - Biological sample reaction chip and biological sample reaction method: A biological sample reaction chip, including: a plurality of reaction containers; a reaction liquid introduction channel having a reaction liquid supply opening at a first end and an evacuation opening at a second end; and a reaction liquid quantifying channel, a third end of which is connected to one of... Agent: Harness, Dickey & Pierce, P.L.C

20090197262 - Bordetella detection assay: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.... Agent: Foley & Lardner LLP

20090197263 - Compare-ms: method rapid, sensitive and accurate detection of dna methylation: The present invention provides methods and kits useful for enriching, identifying and quantifying methylated DNA3 particularly hypermethylated CpG islands by digesting a sample with a methylation-sensitive restriction endonuclease and capturing methylated restriction fragments with a methyl-binding capture reagent. The methods of the invention may be used in the detection of... Agent: Dla Piper LLP (us)

20090197247 - Composition for increasing microorganism wall permeability and method for detecting said microorganisms on a membrane: The present invention relates to a composition for permeabilizing microorganism walls, comprising the combination of polyethyleneimine (PEI) with at least one alcohol, and also to a method using said composition for counting and detecting in a targeted manner the microorganisms on a membrane. The invention also relates to a kit... Agent: Nields, Lemack & Frame, LLC

20090197249 - Compositions and methods for diagnosing colon disorders: The present invention relates to methods and compositions for diagnosing, monitoring, prognosticating, analyzing, etc., polymicrobial diseases. The present invention also relates to the microbial community present in the digestive tract and lumen in normal subjects, and subjects with digestive tract diseases, especially diseases of the colon, such as inflammatory bowel... Agent: Millen, White, Zelano & Branigan, P.C.

20090197275 - Controls for detecting methicillin resistant staphylococcus aureus (mrsa): The invention relates to the quality control of Staphylococcus aureus testing using nucleic acid amplification-based detection assays. A Staphylococcus aureus control containing a quantified amount of the microorganism with high reproducibility across vials and which is used to calibrate, validate, or verify the performance of an MRSA detection assay and... Agent: Orrick, Herrington & Sutcliffe, LLPIPProsecution Department

20090197252 - Detection of mutations: The present invention relates to a polypeptide which is flavin-containing monooxygenase 3 (FMO3), wherein said FMO3 is a polypeptide comprising at least a sequence having at least 85% identity with the polypeptide sequence SEQ ID NO: 15, in particular to a polypeptide which is a functionally altered mutant of flavin-containing... Agent: Fish & Richardson P.C.

20090197255 - Determining a predisposition to cancer: The present invention relates to methods and kits for determining a predisposition for developing cancer, e.g., prostate and/or breast cancer, due to a germline mutation of a NBS1 gene. The present invention also relates to surveillance protocols for developing cancer, e.g., prostate and/or breast cancer, due to germline mutation of... Agent: Cooper & Dunham, LLP

20090197270 - Diagnostic assay for spongiform encephalopathies: The invention provides a method of diagnosis of a spongiform encephalopathy in a diagnostic sample of a valid body tissue taken from a subject, which comprises detecting an increased proteolytic activity in the diagnostic sample, compared with a sample from a control subject.... Agent: Arent Fox LLP

20090197265 - Epigenetic analyses: A method of carrying out epigenetic analysis on an analyte biological sample, the method comprising carrying out chromatin immunoprecipitation on an analyte biological sample, characterised in that the method comprises a step of contacting the analyte biological sample with carrier chromatin. The method of the invention wherein the analyte biological... Agent: Fulbright And Jaworski LLP

20090197271 - Functional nucleic acid ligands to fluorescent proteins: The present invention relates to a nucleic acid aptamer having a first domain that binds to a fluorescent protein. The nucleic acid aptamer forms a molecular complex whereby the aptamer binds a fluorescent protein at the first domain. A constructed DNA molecule, expression systems, and host cells containing the molecular... Agent: Nixon Peabody LLP - Patent Group

20090197259 - Gene signature for diagnosis and prognosis of breast cancer and ovarian cancer: A first embodiment is a breast cancer prognosticator comprising a detection mechanism consisting a 15-gene signature. In addition there are embodiments comprised of 23-gene signatures and 28-gene signatures. The 28-gene signature may also be used for the prognosis of ovarian cancer. A second embodiment is a method to determine metastatic... Agent: West Virginia University Research Corporation

20090197246 - Haplotypes and polymorphisms linked to human thiopurine s-methyltransferase deficiencies: Haplotypes and polymorphisms of thiopurine S-methyltransferase (TPMT) are described that are linked to TPMT deficiencies which can cause potentially fatal toxicity when patients are treated with thiopurines like mercaptopurine, azathioprine, or thioguanine. The mutant alleles as well as PCR fragments, kits and methods for assaying the TPMT genotype of individual... Agent: Siemens Corporation Intellectual Property Department

20090197277 - High density plate filler: A filling apparatus for filling a microplate. The microplate having a plurality of wells each sized to receive an assay. The filling apparatus can comprise an assay input layer having a first surface and an opposing second surface. The assay input layer can comprise an assay input port extending from... Agent: Invitrogen Corporation C/o Intellevate

20090197253 - High frequency of neurexin 1beta signal peptide structural variants in patients with autism: The three β-neurexins have similar roles in synaptogenesis and interact with the neuroligins. Mutations located within the gene encoding neurexin 1 have been identified as molecular markers associated with autism and autism-related disorders. The estimated attributable risk is 2%. The invention provides methods of diagnosing or predicting susceptibility to developing... Agent: Perkins Coie LLP

20090197260 - Method for predicting the viability and vitality of bacteria usable in stressing environment: A method for predicting viability, vitality and stability of bacteria, which are usable in stressing environments, produced in the form of bacterial preparations and packed in a frozen or lyophilised form, includes pre-suspending the bacterial preparations in non-stressing aqueous nutrient medium, carrying out a molecular measurement of at least one... Agent: Young & Thompson

20090197264 - Method for prediction of sensitivity to 5-fluorouracil-type anticancer agent: m

20090197276 - Methods and compositions for predicting compliance with an antidepressant treatment regimen: Methods and compositions are provided for predicting whether a subject will comply with an antidepressant treatment regimen. In practicing the subject methods, a subject's serotonin transporter gene-linked polymorphic region (5HTTLPR) is genotyped. Based on the identified genotype, a particular antidepressant treatment regimen suitable for the patient is determined. Also provided... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090197250 - Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders: Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.... Agent: Davis Wright Tremaine, LLP/seattle

20090197266 - Methods for optimizing clinical responsiveness to methotrexate therapy using metabolite profiling and pharmacogenetics: The present invention provides methods for optimizing clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. The methods of the present invention may further comprise determining the level of at least one long-chain methotrexate polyglutamate (MTXPG) in a sample obtained from the... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090197267 - Methods for optimizing clinical responsiveness to methotrexate therapy using metabolite profiling and pharmacogenetics: The present invention provides methods for optimizing clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. The methods of the present invention may further comprise determining the level of at least one long-chain methotrexate polyglutamate (MTXPG) in a sample obtained from the... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090197268 - Methods for optimizing clinical responsiveness to methotrexate therapy using metabolite profiling and pharmacogenetics: The present invention provides methods for optimizing clinical responsiveness to chemotherapy in an individual through genotypic analysis of polymorphisms in at least one gene. The methods of the present invention may further comprise determining the level of at least one long-chain methotrexate polyglutamate (MTXPG) in a sample obtained from the... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090197273 - Novel n-acetylgalactosamine transferases and nucleic acids encoding the same: The present invention uses a protein having the amino acid sequence shown in SEQ ID NO: 1, 3, 26 or 27 in the Sequence Listing or a variant of said amino acid sequence wherein one or more acids are substituted or deleted, or one or more acids are inserted or... Agent: Nixon & Vanderhye, PC

20090197257 - Paired-end reads in sequencing by synthesis: The disclosure provides methods of generating paired reads in sequencing-by-synthesis process, particularly, in systems with relatively short read lengths (e.g., 15-35 bases), such as for example, in single molecule sequencing by synthesis. Several implementations of the methods are provided. Of particular advantage are the methods that permit re-sequencing of the... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090197258 - Primary rat hepatocyte toxicity modeling: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090197251 - Process for marking products with nucleic acids for proving the identity and origin of the products: The invention relates generally to product identification and, more particularly, to processes for marking products with nucleic acids to establish the identity and origin of the products, to track them and to determine their quantity in the event of blending or dilution with other products. The invention also relates to... Agent: Fox Rothschild LLP

20090197269 - Translocation and mutant csf1r kinase in human leukemia: In accordance with the invention, a novel gene translocation, (3p21, 5q33), in human myelogenous leukemia (AML) that results in a fusion protein combining part of RNA Binding Protein-6 (RBM6) with Macrophage Colony Stimulating Factor-1 Receptor (CSF1R) kinase has now been identified. The RBM6-CSF1R fusion protein and truncated CSF1R kinase itself,... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20090197256 - Use of a fibroblast growth factor-binding protein for the treatment and diagnosis of diabetic wound healing problems: The present invention relates to the use of fibroblast growth factor-binding protein (FGF-BP) polypeptides, and functional variants of these polypeptides, respectively, or of nucleic acids encoding these polypeptides or variants, or of functional variants of these nucleic acids, and/or of a cell which is expressing an FGF-BP polypeptide or functional... Agent: Clark & Elbing LLP

20090197254 - Variant scorpion primers for nucleic acid amplification and detection: Disclosed herein are methods of detecting target nucleic acids. In particular, methods for avoiding loss of the fluorescent label form an amplicon that is generated using a Scorpion primer and a polymerase with 5′ exonuclease activity. The methods use a Scorpion primer which comprises a fluorophore, a quencher, and in... Agent: Foley & Lardner LLP

20090197248 - Vitro evolution in microfluidic systems: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090197272 - Vitro method of detecting and/or diagnosing cancer using uv light based dna image cytometry: The invention relates to a method of determining in vitro the amount of nuclear DNA within a human or animal cell using UV absorption measurement with UV light. The invention also relates to a method for detecting in vitro cancerous cells in a biological sample relying on the aforementioned principles.... Agent: Philips Intellectual Property & Standards

20090197278 - Antibodies to hada2: Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20090197280 - Methods and devices for rapid assessment of severity of injury: Methods and devices for rapid assessment of the severity of injury not due to a natural disease based upon measurement of neutrophil gelatinase-associated lipocalin (NGAL) are provided.... Agent: Licata & Tyrrell P.C.

20090197281 - Methods for diagnosis and treatment of chronic immune diseases: Methods are provided for diagnosing and/or characterizing chronic immune disease activity in a subject. In the subject methods, a sample is obtained from a subject suspected of having or known to have a chronic immune disease. The sample is then assayed for the presence of native Stat-1 protein and/or any... Agent: Bozicevic, Field & Francis LLP

20090197279 - Microtubule synthesis as a biomarker: Stable isotope labeling was used to measure dynamics of tubulin incorporation into microtubule subpopulations representing different neuronal compartments in the murine hippocampus. Neuronal microtubules were largely static. Basal turnover was highest in tau-associated (axona) and growth cone), lower in MAP2-associated (somatodendritic), and lowest in cold stable (axonal shaft) subpopulations. Intracerebroventricular... Agent: Morgan, Lewis & Bockius, LLP

20090197282 - Method and system for screening the receptor-ligand binding in live cell: The invention relates to methods and system for detecting ligand binding to membrane receptors and endocytosis. A method for detecting ligand binding to a membrane receptor includes the steps of: incubating the cell with a dye and a ligand; and detecting dye-containing endocytic vesicles in the cell. A system for... Agent: Osha Liang L.L.P.

20090197284 - Analysis of proteins from biological fluids using mass spectrometric immunoassay: Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins present in complex biological fluids or extracts. Pipettor tips containing porous solid supports that are covalently derivatized with affinity ligand and used to extract specific proteins and their variants from various biological fluids. Nonspecifically bound... Agent: Snell & Wilmer L.L.P. (main)

20090197285 - Lung cancer diagnostic assay: A diagnostic assay for determining presence of lung cancer in a patient depends, in part, on ascertaining the presence of an antibody associated with lung cancer. The assay predicted lung cancer prior to evidence of radiographically detectable cancer tissue.... Agent: Whiteford, Taylor & Preston, LLP Attn: Gregory M Stone

20090197283 - Devices and methods for the collection and detection of substances: The present invention is a single self-contained device for collecting, transferring, extracting, and testing for the presence of a target analyte in a sample obtained from a surface by swabbing, solid materials (pills, capsules, unknown powders), air samples and biological and non-biological fluids. The device includes a swab, a retention... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090197286 - Methods and kit for diagnosing t1dm: A method of diagnosing Type 1 Diabetes Mellitus (T1DM) in a subject in need thereof is provided. The method comprising determining a presence and/or a level of antibodies in a biological sample of the subject, wherein the presence or level above a predetermined threshold is indicative of T1DM, thereby diagnosing... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090197287 - Systems and methods for characterizing kidney disease: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the... Agent: Casimir Jones, S.c.

20090197288 - Multiple quantification of cholesterol in low density lipoprotein: The present invention is intended to provide a method for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol as test components in blood. Specifically, a method is used for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol in a biological sample, whereby cholesterol in low density... Agent: Foley And Lardner LLP Suite 500

20090197289 - Method for confirming a diagnosis of autism: A method for confirming a diagnosis of autism in of an individual comprises obtaining a sample of feces from an individual, determining a quantitative level of chymotrypsin present in the sample, and comparing the quantitative level of fecal chymotrypsin in the stool sample of the person having autism to a... Agent: Kristina M. Grasso Kristina M. Grasso, Esq. PLLC

20090197290 - Methods and kits for diagnosis of non-septic shock: Methods and kits for diagnosis and staging of non-septic shock are presented in which one or more protease activities are measured from a biological sample to so identify and/or stage non-septic shock. Most preferably, at least two protease activities are correlated, however, additional or alternative markers may also be measured.... Agent: Fish & Associates, PC Robert D. Fish

20090197291 - Assays using nanoparticles: A method for quantitatively and qualitatively determining the presence of a macromolecule comprises providing nanoparticles in a buffered solution, adding a test sample to the buffered nanoparticle solution, and measuring the difference between the buffered nanoparticles in the presence and absence of the test sample. The nanoparticles are preferably less... Agent: Jacobson Holman PLLC

20090197295 - Masks useful for maldi imaging of tissue sections, processes of manufacture and uses thereof: The present invention relates to masks for use in mass spectrometry, in particular MALDI, tissue section analysis, comprising a plate made of or coated by an opaque material and having a thickness of less than 150 μm, said plate comprising regularly spaced openings, wherein in the plate upper plane, the... Agent: Foley And Lardner LLP Suite 500

20090197297 - Molecularly imprinted polymer sensor device: A molecularly imprinted polymer sensor device for detecting the presence of a taggant molecular structure in a fluid is disclosed. The molecularly imprinted polymer sensor device comprises a molecularly imprinted crosslinked polymer having a crosslinked core and a plurality of polymer arms attached to the core, wherein the core has... Agent: The Johns Hopkins Universityapplied Physics Labora Office Of Patent Counsel

20090197294 - Mrd-based reactors: The present invention depicts an MRD-based reactor. The MRD-based reactor comprises of a means for containing a flowing media and reacting the same (reactor). The reactor is characterized by a continuous wall portion, and is in connection with at least one MRD, adapted for applying localized spectroscopy towards the media.... Agent: Fleit Gibbons Gutman Bongini & Bianco Pl

20090197293 - Novel use of an indicator cell line for bioassay: The present invention relates to methods of bioassay for detecting the effective concentration of Granulocyte Colony Stimulating Factor (G-CSF), and estimating ED50 and specific activity of G-CSF using a human acute myeloid cell line. The invention also relates to use of this technique for estimating the potency of G-CSF samples... Agent: Blank Rome LLP

20090197296 - Optical indicator for detecting bacterial pathogens: A clinical testing assay device that can differentiate bacterial from viral infections is described. The assay device has a sample contact zone with an absorbent pad on which a test sample is deposited and a detection zone with a colorant indicator that is sensitive to bacteria cells. The colorant indicator... Agent: Kimberly-clark Worldwide, Inc. Catherine E. Wolf

20090197292 - Systems and methods for ex vivo lung care: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through... Agent: Wilmerhale/dc

20090197298 - Method for detecting microorganisms in a biological sample: This invention relates to a method for detecting at least one specific microorganism in a biological sample, said method comprising the following steps: a) culturing said biological sample in a culture medium, b) subjecting said culture medium to at least two radiations each presenting a specific wavelength, c) obtaining at... Agent: Baker Donelson Bearman, Caldwell & Berkowitz, PC

20090197299 - Method for assessing airborn microorganisms: The present invention relates to an environmental sampling method for assessing airborne microorganisms. The method comprises retaining organisms suspended in air to a polymeric pad via gravitational settling or forced impact, dissolving the polymeric pad in a buffered salt solution, and determining the number and kind of microorganisms in the... Agent: Merck And Co., Inc

20090197302 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family having attenuated expression of the nac gene: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the nac gene.... Agent: Cermak & Kenealy LLP Acs LLC

20090197300 - Mutually exclusive domain folding molecular switch and method of synthesis thereof: The invention is a fusion protein, embodying a mutually exclusive folding domain molecular switch, wherein the free energy released by folding of a first domain of the fusion protein drives an unfolding of a second domain of the fusion protein, and vice versa. The fusion protein is engineered so that... Agent: Sander Rabin Md Jd A Professional Corporation

20090197303 - Process for producing dipeptides: The present invention provides: a protein having dipeptide-synthesizing activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant transformed with the recombinant DNA; a process for producing the protein having dipeptide-synthesizing activity using the transformant or the like; a process for producing a dipeptide using the protein... Agent: Fitzpatrick Cella Harper & Scinto

20090197301 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Goodwin Procter LLP

20090197304 - Corynephage integrase-based site-specific insertion vector system: The present invention provides a system for site-specific directed gene insertion of desired genes or foreign DNA into cellular genomes. The system includes novel vectors for integrating DNA into the genome of different hosts. Methods of using the vectors and transformed hosts are described.... Agent: Elizabeth Hart-wells, Ph.d. University Of Maryland, Baltimore

20090197305 - Process for the preparation of polymyxin b employing (paeni) bacillus polymyxa: The invention is related to the process of fermentation with production strain Bacillus polymyxa for industrial production of antibiotic polymyxine B with yield from 1.8 to 2.8 g/l of filtrate of fermentation broth at temperature 28° C., pressure 40-70 kPa, aeration from 0.4 to 1 vvm, concentration of dissolved oxygen... Agent: Michael Best & Friedrich LLP

20090197306 - Thermal cycling device: A multi-layer device suitable for thermal cycling is set forth. The device is particularly suitable for performing a polymerase chain reaction (PCR). One embodiment includes a first layer (18), a second layer (20) adjacent to the first layer, and a third layer (22) adjacent to the second layer opposite the... Agent: Dickinson Wright PLLC

20090197307 - Compositions and methods for preparing short rna molecules and other nucleic acids: The invention provides methods of preparing nucleic acids, such as RNA molecules, of a defined size or range of sizes. The invention provides compositions, methods and kits for use in the production and preparation of small RNA molecules (including without limitation micro-RNA, siRNA, d-siRNA and e-siRNA) and other nucleic acids... Agent: Invitrogen Corporation C/o Intellevate

20090197308 - Enzymatic synthesis of sulfated polysaccharides: A method of sulfating a polysaccharide is provided. The method can include providing a reaction mixture comprising at least one O-sulfotransferase (OST) enzyme and 3′-phosphoadenosine 5′-phosphosulfate (PAPS); incubating a polysaccharide substrate with the reaction mixture, wherein production of the sulfated polysaccharide from the polysaccharide substrate is catalyzed by the OST... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20090197309 - Mutant acetolactate synthase and a method for producing branched-chain l-amino acids: A mutant bacterial acetolactate synthase (AHAS I) which is resistant to feedback inhibition by L-valine is described. Also described is a method for producing branched-chain L-amino acids using a bacterium from the Enterobacteriaceae family wherein the L-amino acid productivity of said bacterium is enhanced by the use of the acetolactate... Agent: Cermak & Kenealy LLP Acs LLC

20090197310 - Biosyntheses of salinosporamide a and its analogs and related methods of making salinosporamide a and its analogs: Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve, for example, genetic manipulation, selection of reagents in the fermentation feedstock, and selection of fermentation conditions.... Agent: Knobbe Martens Olson & Bear LLP

20090197311 - Method for the production of simvastatin: The present invention provides a fermentative process for the synthesis of simvastatin by providing a host capable of incorporating the 2,2-dimethylbutyrate side chain into simvastatin, i.e. by customizing a polyketide synthase gene optimized for synthesis and/or incorporation of 2,2-dimethylbutyrate; optionally feeding said host with the appropriate substrate for 2,2-dimethylbutyrate synthesis;... Agent: Nixon & Vanderhye, PC

20090197312 - Production of fat from alcohol: The present invention concerns a process for forming a lipid or a mixture of lipids from a starting material, which comprises at least one alcohol and a soap or a soap precursor, the process comprising adding a metal-ion forming agent to the starting material, whereby a mixture is formed, which... Agent: Dodds & Associates

20090197313 - Method for preparing xylitol with high yield using recycling microorganism: Provided is a process for continuously producing xylitol in high yield and productivity using a vacuum microfiltration bioreactor containing a fermentation medium for a strain of the genus Candida, which includes: 5 300 g/l of xylose, 1 10 g/l of urea, 1 10 g/l of potassium diphosphate, 0.01 1 g/l... Agent: Occhiuti Rohlicek & Tsao, LLP

20090197314 - Modified microorganisms with inactivated lactate dehydrogenase gene: Modified microorganisms are prepared by inactivation of the endogenous lactate dehydrogenase gene. The microorganisms are deposited under NCIMB Accession Nos. 41277, 41278, 41279, 41280 or 41281.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090197315 - Fullerene-based amino acids: The present invention is directed to a series of new compounds, combining the unique properties of fullerenes and bio-active amino acid residues, and to methods for making such compounds. The present invention is directed toward fullerene-based amino acids, and to amino acid residues, peptide chains, proteins, and polypeptides made from... Agent: Winstead PC

20090197316 - Process for preparing particles of proteinaceous material: Protein particles are prepared by causing or allowing protein molecules dispersed in a liquid medium at a concentration of 8 mg.mL-1 or greater to react in the presence of a zero-length crosslinker, so as to produce protein particles comprising protein molecules that are covalently bonded together. The protein particles may... Agent: Novozymes North America, Inc.

20090197317 - Tsg-like gene: A gene encoding a novel protein that is homologous to Drosophila TSG was isolated from a cDNA library derived from the AGM region of mouse embryos by using an originally developed cloning method specific to a gene encoding a membrane secretory protein. This gene is useful in developing drugs that... Agent: Fish & Richardson PC

20090197318 - Crystallization of enzyme and method for producing same: The present invention provides a method of crystallizing of enzymes. The method is for rapidly crystallizing enzymes from impure mixtures. The method is simple and cheap, and it is compatible to industrial requirements. T1 lipase was able to form crystals at low protein concentration (2.5 mg/ml) in a day. High... Agent: Edwards Angell Palmer & Dodge LLP

20090197320 - Ancestral dengue virus envelope protein: Disclosed is a dengue virus envelope protein sequence derived via ascertainment of a most recent common ancestor of the three dengue serotype variants, DENV-1, DENV-2, DENV-3 and DENV-4. This synthetic dengue virus envelope protein can be used as a tetravalent vaccine in the prevention of dengue fever, dengue hemorrhagic fever... Agent: Husch Blackwell Sanders LLP

20090197319 - Virus-like particle containing a dengue recombinant replicon: A diagnostic assay for detecting antibody, in part, to human papilloma virus includes a virus-like particle that expresses human papilloma virus antigen.... Agent: Mdip LLC

20090197321 - Strain of genetically reengineered escherichia coli for biosynthesis of high yield carotenoids after mutation screening: The present invention relates to a strain of Escherichia coli (E. coli M2H) for biosynthesis of high yield carotenoids, the steps for obtaining E. coli M2H comprises: purifying the host strain JCL1613 for pCW9/P2IDI; create plasmids for producing carotenoid genes; transform the plasmids into JCL1613; utilizing physical method (UV) to... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20090197322 - Solar plant employing cultivation of organisms: A method of growing algae is described that is part of a cogenerational energy production plant in which solar energy from a solar collecting and concentrating field is used to provide photonic energy for the growth and stress phase of algae as well as to provide heat for driving a... Agent: Miles & Stockbridge PC

20090197323 - Identification and characterization of a novel alpha-amylase from maize endosperm: SHE, a Starch Hydrolytic Enzyme active in maize endosperm (Zea mays), and the cDNA sequence encoding SHE are disclosed. The specificity of native, purified SHE is similar, in general terms, to previously known alpha-amylases. However, the activity of SHE toward amylopectin results in hydrolysis products that are distinctly different from... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20090197325 - Systems and methods for ex vivo lung care: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through... Agent: Wilmerhale/dc

20090197324 - Systems and methods for ex vivo lung care: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through... Agent: Wilmerhale/boston

20090197326 - Biological analysis arrangement and approach therefor: Characteristics of a chemical or biological sample are detected using an approach involving light detection. According to an example embodiment of the present invention, an assaying arrangement including a light detector is adapted to detect light from a sample, such as a biological material. A signal corresponding to the detected... Agent: Crawford Maunu PLLC

20090197327 - Culturing bag: A culturing bag for microorganisms has a wall formed of plastic film wherein at least one wall area of the wall is permeable for oxygen and carbon dioxide. A first layer of microporous film is attached to the at least one wall area as an exterior layer so as to... Agent: Gudrun E. Huckett Draudt

20090197328 - Process and apparatus for producing entrapping immobilization pellets: A large amount of entrapping immobilization pellets with highly stable quality are produced inexpensively by high-speed treatment. There is provided a process for producing entrapping immobilization pellets in which microorganisms are entrapped and immobilized in an immobilizing agent, the process comprising polymerizing a mixture containing the microorganisms and a solution... Agent: Oliff & Berridge, PLC

20090197329 - Apparatus and method for separating biological particles using difference between gravity and magnetic force: Disclosed is an apparatus and method for injecting liquid-drops of particle mixture liquid including a mixture of biological particles, affecting magnetic field, and having only positive particles, which are combined with magnetic responsive material, separated by magnetic force, and having negative particles, which are not combined with magnetic responsive material,... Agent: Merchant & Gould PC

20090197330 - Anti-cd20 monoclonal antibody: Disclosed is a monoclonal antibody capable of inducing a specific biological reaction through the binding of the monoclonal antibody to a CD20 antigen on the surface of a cell. A monoclonal antibody having a high binding affinity to an extracellular epitope of a CD20 antigen and also having biological activities... Agent: Knobbe Martens Olson & Bear LLP

20090197331 - Compositions for cryopreservation of cells: A composition for the cryopreservation of cells according to the present invention at least comprises sericin and one or more components selected from the group consisting of amino acids and saccharides. Further, a method for the cryopreservation of cells according to the present invention comprises the steps of placing target... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090197332 - Modified short interfering rna: The present invention refers to a double-stranded siRNA molecule comprising a sense Strand and an antisense Strand which is essentially complementary to the sense Strand, each of the sense and the antisense Strands comprising at least 17 nucleotides (nt), the siRNA further comprising at least one overhang at the 5′... Agent: Mcdermott Will & Emery LLP

20090197333 - Method for production of biological organic material and culture vessel: Disclosed is a method for producing a biological organic material in a liquid droplet comprising a culture medium composed of specified ingredient. The method comprises the steps of: providing a substantially spherical liquid droplet on a substrate in an unadhered state, the substrate preferably having such a water-repellent surface that... Agent: Turocy & Watson, LLP

20090197334 - Methods of culturing embryonic stem cells and controlled differentiation: The present invention provides a preparation of undifferentiated embryonic stem (ES) cells sustainable for a prolonged period in an undifferentiated state which will undergo stem cell renewal or somatic differentiation. Preferably the cells are capable of somatic differentiation in vitro and are inclined to differentiate away from an extraembryonic lineage.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090197335 - Method for improved transfer of dna into living cells by electroporation: The subject invention concerns an electroporation buffer that allows for enhanced transfection efficiency and cell viability of cells during application of an electric current. Buffers of the invention provide for maximum transfer of target particles into cells while maintaining the health and growth potential of the cell population. Compositions of... Agent: Greenberg Traurig, LLP

20090197336 - Suppression of polymorphic alleles: Methods and agents for suppressing expression of a mutant allele of a gene having a polymorphism are provided. The methods of the invention provide suppression effectors such as antisense nucleic acids or ribozymes, that bind to nucleic acid regions having a polymorphism within a gene such that one allele of... Agent: Wolf Greenfield & Sacks, P.C.

20090197337 - Methods for the production of multimeric proteins and related compositions: Improved methods for the production of multimeric-protein-complexes, such as redox proteins and immunoglobins, in association with oil bodies are described. The redox protein is enzymatically active when prepared in association with the oil bodies. Also provided are related nucleic acids, proteins, cells, plants, and compositions.... Agent: Foley And Lardner LLP Suite 500

20090197339 - In vivo unnatural amino acid expression in the methylotrophic yeast pichia pastoris: The invention provides orthogonal translation systems for the production of polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris. Methods for producing polypeptides comprising unnatural amino acids in methylotrophic yeast such as Pichia pastoris are also provided.... Agent: Quine Intellectual Property Law Group, P.C.

20090197338 - Method of increasing the function of an aav vector: A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid... Agent: Howson & Howson LLP

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