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Chemistry: molecular biology and microbiology July category listing 07/09

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
07/30/2009 > patent applications in patent subcategories. category listing

20090191533 - Process for preserving tissues: A process for preserving tissues is described which comprises transferring the tissues in a container and evacuating the container.... Agent: The H.t. Than Law Group

20090191534 - System and sequential culture media for in vitro fertilization: Instead of immersing human reproductive cells in a single culture medium throughout the various procedures used in IVF, a process is provided by which the reproductive cells may be moved through a sequence of distinct culture media as the various IVF procedures are carried out. In one implementation, the culture... Agent: Foley & Lardner LLP

20090191537 - Medium and methods for the storage of platelets: Synthetic storage media are disclosed for use in the processing and the storing of platelets. The storage media includes a platelet storage solution and less than 20 percent plasma to preserve platelet function after at least 7 days of storage.... Agent: Cook Alex Ltd

20090191535 - Method of assessing metastatic carcinomas from circulating endothelial cells and disseminated tumor cells: A method for assessing cancer in test subjects is described based upon enumeration of circulating endothelial cells and/or disseminated tumor cells in a test subject. This method is used to quantify disseminated tumor cells. Correlations with circulating tumor cells provides prognostic information with high accuracy in assessing the risk of... Agent: Philip S. Johnson Johnson & Johnson

20090191536 - Rabbit monoclonal antibodies to hepatitis b surface antigens and methods of using the same: Reagents, methods and immunodiagnostic test kits for the accurate detection of hepatitis B virus (HBV) infection are disclosed. The methods and kits employ novel rabbit monoclonal antibodies directed against HBV surface antigens (HBsAg) with mutations in the “a” determinant region of HBsAg.... Agent: Novartis Vaccines And Diagnostics Inc.

20090191540 - Markers for viral infections and other inflammatory responses: Compositions and methods for the detection, diagnosis and treatment of BVDV are provided.... Agent: Dann, Dorfman, Herrell & Skillman

20090191539 - Primers for isothermal amplification of hepatitis c virus: The present application relates to primers for isothermal amplification of HCV each include at least eighteen consecutive bases corresponding to a 3′ end region of one selected from base sequences of SEQ ID NOs: 1-10, 21 and 22. The primers are specific to HCV subtypes 1a, 1b, 2a, 2b and... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090191538 - Selective detection of oncogenic hpv: Compositions and methods for discriminately detecting the presence of a set of related genes from target organisms while avoiding detection of closely similar genes in non-target organisms. The present invention achieves this objective by a variety of novel nucleic acid constructs and methods. The nucleic acid constructs of the present... Agent: Natalie Bogdanos, Esq. C/o Enzo Biochem, Inc.

20090191553 - Chase ligation sequencing: In various embodiments, the present teachings provide sequencing methods which facilitate enhancing the efficiency of ligation and/or increasing sequencing reads. Various embodiments of the methods enable sequencing through template regions for which complementary labeled extension probes are unavailable or insufficient. In various embodiments, one or more rounds of ligation with... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090191544 - Correlating chemical and spatial data within pathology samples: A tissue sample to be analyzed is tested. Multiple different samples of multiple areas of said tissue sample, each of said multiple areas is a smaller area than an entire tissue sample to be analyzed. After analysis, the tissue sample is processed in a way that facilitates viewing tumor information... Agent: Fish & Associates, PC Robert D. Fish

20090191558 - Detection, identification and differentiation of serratia species using the spacer region: t

20090191550 - Diagnosis of whipple's disease: The invention relates to a method for in vitro seriological diagnosis of Whipple's disease, whereby the bacteria responsible for the disease are isolated and established in a culture and brought into contact with the serum or biological fluid of an infected patient. The invention also relates to useful oligonucleotides with... Agent: Oliff & Berridge, PLC

20090191564 - Diagnostics and therapeutics for cardiovascular disorders: The methods of the present invention relate to the diagnosis of cardiovascular disorders. In one aspect, the specification discloses methods for determining a subject's predisposition to increased risk for myocardial infarction.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090191546 - Engineered toehold reactions and networks: A catalytic system and method of catalyzing reactions that uses a novel toehold exchange mechanism that allows a specified input to catalyze the release of a specified output, which in turn can serve as a catalyst for other reactions is provided. This toehold exchange catalyst system, which can be driven... Agent: Kauth , Pomeroy , Peck & Bailey ,llp

20090191547 - Exon grouping analysis: This invention pertains to the identification of specific disease-causing DNA sequences in a subject. The methods of the present invention can be used to identify genetic alterations, to determine the molecular basis for genetic diseases, and to provide carrier and prenatal diagnosis for genetic counseling.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090191555 - Hcv ns3-ns4 protease resistance mutants: The present invention is directed to mutants of HCV NS3/4A protease. More particularly, the present invention identifies mutant of HCV NS3/4A protease that are resistant to drug treatment.... Agent: Marshall, Gerstein & Borun LLP

20090191559 - Her2 diagnostic methods: In certain aspects, the present invention provides methods for determining whether a Her-2 positive cancer is likely to respond to treatment with a Her2-acting agent and/or whether a patient with a Her-2 positive cancer is likely to have a slow disease progression. In other aspects, the present invention is drawn... Agent: Monogram/fenwick

20090191543 - Identification of rac1b as a marker and mediator of metalloproteinase-induced malignancy: The present invention provides compositions and methods for detecting MMP-induced malignancies by detecting Rac1b expression. The invention further provides compositions and in vitro and in vivo methods for inhibiting MMP-induced malignant transformation by modulating Rac1b expression and/or function.... Agent: Lawrence Berkeley National Laboratory

20090191566 - Kits for isolating nucleic acids using multifunctional group-coated solid phase carriers: The present invention is directed to a method of isolating a target species (e.g., target nucleic acid species) from a mixture. In the methods of the present invention, the mixture is combined with solid phase carriers having a surface comprising multiple functional groups one of which reversibly and selectively binds... Agent: Michael C. Schiffer - Legal Dept. Beckman Coulter, Inc.

20090191569 - Mammalian cytokines; related reagents: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Schering-plough Biopharma Legal Department

20090191556 - Method: The present invention relates to a novel method for the delivery of agents to tumour cells. In particular it relates to a method for the specific delivery of agents to the interior of tumour cells. Uses of the method are also described.... Agent: Marshall, Gerstein & Borun LLP

20090191562 - Method for assaying reg iv mrna: In an RNA amplification process comprising steps of using a first primer and a second primer, at least one of which has a promoter sequence at the 5′ end, and reverse transcriptase, to produce double-stranded DNA containing the promoter sequence, using the double-stranded DNA as template to produce an RNA... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090191568 - Methods and compositions for predicting compliance with an antidepressant treatment regimen: Methods and compositions are provided for predicting whether a subject will comply with an antidepressant treatment regimen. In practicing the subject methods, a subject's serotonin transporter gene-linked polymorphic region (5HTTLPR) is genotyped. Based on the identified genotype, a particular antidepressant treatment regimen suitable for the patient is determined. Also provided... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090191548 - Methods and nucleic acids for the analysis of gene expression associated with tissue classification: The present application provides methods and nucleic acids the classification of a biological sample. This is achieved by the analysis of the expression status of at least one of the genes selected from Table 1 as disclosed.... Agent: Davis Wright Tremaine, LLP/seattle

20090191561 - Methods and oligonucleotides for detection of mastitis causing bacteria: The present invention relates to the field of polymerase chain reaction (PCR) based diagnostic assays. More specifically, the present invention provides a PCR-method for detecting mastitis causing bacteria, particularly Staphylococcus aureus and coagulase negative staphylococci. The present invention also provides oligonucleotide primers and probes for use in said method.... Agent: Birch Stewart Kolasch & Birch

20090191557 - Mn/ca ix/ca9 and renal cancer prognosis: Herein disclosed are methods that are prognostic for renal cell carcinoma, particularly renal clear cell carcinoma, afflicting a vertebrate. An exemplary prognostic method comprises detecting the presence of, and quantitating the level and/or extent of a MN/CA9 gene expression product in a sample from the affected subject, wherein if 50%... Agent: Leona L. Lauder Attorney At Law

20090191554 - Modified glass fiber with monolayer of aminocalixarene derivatives and iminecalixarene derivatives: Techniques for a surface-modified glass fiber with monolayer of aminocalixarene derivatives and iminecalixrene derivatives are provided.... Agent: Blakely Sokoloff Taylor & Zafman LLP

20090191542 - Multi-variant cell indication technique: The invention provides methods for identifying and isolating cells that express high levels of protein. A method is described for identifying a cell or cell line expressing a desired protein comprising determining in a cell or cell line that has been transfected with a vector comprising a nucleotide sequence encoding... Agent: Xcellerex, Inc. Attention: Jacqueline Arendt

20090191560 - Mutant dna polymerases and uses therof: The present invention relates to mutant DNA polymerases which incorporate dideoxynucleotides with about the same efficiency as deoxynucleotides. The present invention also related to mutant DNA polymerases which also have substantially reduced 5′-to-3′ exonuclease activity or 3′-to-5′ exonuclease activity. The invention also relates to DNA molecules coding for the mutant... Agent: Invitrogen Corporation C/o Intellevate

20090191552 - Novel human acidic mammalian chitinase and use thereof: Described herein is a variant human acidic mammalian chitinase (AMCase) enzyme having improved stability and an isolated nucleic acid sequence which encodes the variant. The invention also provides to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing recombinant variant AMCase... Agent: Merck And Co., Inc

20090191545 - Selection of high-producing cell lines: The invention describes a method for screening antibody producing cell lines for selection of high expressing clones.... Agent: Philip S. Johnson Johnson & Johnson

20090191567 - Semiconductor nanocrystal probes for biological applications and process for making and using such probes: A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents,... Agent: Bozicevic, Field & Francis LLP

20090191565 - Short cycle methods for sequencing polynucleotides: The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or fill completion.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090191549 - Single nucleotide polymorphisms (snp) and their association with tick resistance in bovine animals: e

20090191563 - Uniform fragmentation of dna using binding proteins: The invention provides a method for preparing and analysing a population of fragmented polynucleotide sequences having a substantially uniform size. The method can include steps of (a) binding at least some protection molecule to at least one polynucleotide sequence; (b) cleaving the at least one polynucleotide sequence to generate a... Agent: Illumina, Inc. Legal Department

20090191551 - Use of secretor, lewis and sialyl antigen levels in clinical samples as predictors of risk for disease: An individual at risk for necrotizing enterocolitis and related disorders can be identified by measuring the level of at least one secretor antigen in a biological sample from the individual and comparing the measured level of the at least one secretor antigen to a predetermined value or a predetermined range... Agent: Fish & Richardson PC

20090191570 - Inhibition of interaction of psd93 and psd95 with nnos and nmda receptors: PSD-95/SAP90 antisense-treated animals not only experience a significant decrease in MAC for isoflurane, but also experience an attenuation in the NMDA-induced increase in isoflurane MAC. PSD-95/SAP90 appears to mediate the role of the NMDA receptor in determining the MAC of inhalational anesthetics. Suppression of the expression of PSD-95/SAP90 in the... Agent: Banner & Witcoff, Ltd.

20090191571 - Isolation and detection of pathogenic prions: Peptide reagents that interact preferentially with the PrPSc form of the prion protein are described. In addition, methods of using these peptide reagents in combination with peptide probes, which aggregate in response to binding pathogenic prion proteins and that can be used for detection of pathogenic prion proteins, are disclosed.... Agent: Morrison & Foerster LLP

20090191572 - Imaging, diagnosis and treatment of disease: The present invention relates to endothelial cell-specific genes and encoded polypeptides and materials and uses thereof in the imaging, diagnosis and treatment of conditions involving the vascular endothelium.... Agent: Wolf Greenfield & Sacks, P.C.

20090191573 - Method and kit for determining antigen content in a sample using double immunohistochemical detection: A method for determining antigen content in a region of interest of a sample is disclosed. The method includes a sequential immunomarking resulting in two chromogenic signals, which are respectively provided by a labile and a stabile chromogenic product. The method further involves acquisition, analysis and evaluation of digital images... Agent: Knobbe Martens Olson & Bear LLP

20090191574 - Methods, products and treatments for diabetes: The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided.... Agent: Harvard University & Medical School C/o Wolf, Greenfield & Sacks, P.C.

20090191575 - Tumor marker and method for determination of the occurrence of cancerous disease: The present invention provides a tumor marker and a method capable of identifying the morbidity of colon cancer. A tumor marker including a protein identified from a colon cancer tissue. A method for identify the morbidity of colon cancer using the tumor marker. The method includes: measuring the level of... Agent: Cheng Law Group, PLLC

20090191576 - Method and index for diagnosing insulin resistance: The invention provides methods for the determination of insulin sensitivity, insulin resistance, and non-insulin dependent Diabetes mellitus based on oral glucose tolerance test data and lipid ratios from reference populations that define an insulin resistance index. The invention also provides methods for using the IR index to determine disease progression... Agent: Lynn E. Murry

20090191577 - Method and medium for detecting the presence or absence of staphylococcus aureus in a test sample: A presence/absence test for Staphylococcus aureus (S. aureus) involves placing a first generation test sample in a solution that will clot in the presence of S. aureus. The solution contains components that will selectively grow S. aureus and also contains clotting factors that will react with S. aureus, if S.... Agent: O''shea Getz P.C.

20090191579 - Analgesia with minimal tolerance and dependence by a mu opioid receptor agonist that also binds filamin a: A composition and method are disclosed that utilize an isolated polypeptide or analog thereof to inhibit the interaction of a mu-opioid receptor with filamin A. A contemplated polypeptide has an amino acid residue sequence illustrated by the formula: W-[X1X2X3 . . . X43X44X45]nValAlaX48GlyLeu[X51X52X53 . . . X94X95X96]m-Y, wherein the various... Agent: Husch Blackwell Sanders, LLP Husch Blackwell Sanders LLP Welsh & Katz

20090191578 - Canis sphingosine 1-phosphate receptor isoform 5: A Canis sphingosine-1-phosphate (S1P) receptor isoform 5 (cS1P5), the nucleic acid encoding the cS1P5 receptor, and methods for using the cS1P receptor and the nucleic acid encoding the cS1P5 receptor in assays for identifying analytes which modulate activity of the cS1P5 receptor. The assay is useful for identifying analytes for... Agent: Merck And Co., Inc

20090191581 - Cell-permeable fluorescent proteins: This invention relates to methods and compositions for designing novel fluorescent proteins, preferably to a green fluorescent proteins (GFP). The engineered GFPs are modified by substituting negatively charged amino acids with positively charged amino acids on the exterior of the protein making the protein cell permeable. The ability of the... Agent: Quarles & Brady LLP

20090191582 - Enzyme detection: An enzyme detection product (1) for detecting the presence of an enzyme in a sample. The product (1) comprises: a reaction zone (16) for receiving the sample; a visualization zone (10) for presenting a signal in response to the detection of the activity of the enzyme; and a membrane (11).... Agent: Clark & Elbing LLP

20090191580 - Method of screening using c-met, a novel substrate for gamma-secretase:

20090191583 - Clostridial toxin activity assays: Compositions useful for detecting Clostridial toxin activity comprising a cell that contains an exogenous Clostridial toxin substrate comprises a fluorescent member, a membrane targeting domain and a Clostridial toxin recognition sequence comprising a cleavage site, where the cleavage site intervenes between said fluorescent member and said membrane localization domain and... Agent: Allergan, Inc.

20090191584 - Transcriptional repression of sodium-iodide symporter in thyroid carcinoma: The present disclosure relates to a sodium iodide symporter (NIS)-repressor binding site (NRBS) consisting of a DNA molecule spanning from −645 to −605 nucleotides (SEQ ID NO:4) or from −648 to −620 nucleotides (SEQ ID NO:5) upstream from the translation start site of human NIS gene. The disclosure further relates... Agent: Mcdermott Will & Emery LLP

20090191585 - Cell image processing apparatus, cell image displaying system and cell image displaying method: A cell image processing apparatus includes a large area image obtainer for obtaining a large area image which is obtained by imaging an area including a white blood cell and a red blood cell, a processing part for obtaining a portion image including the white blood cell from the large... Agent: Sughrue Mion, PLLC

20090191586 - Enzyme expression methods and compositions: Methods for expressing active enzymes are described that involve co-expressing a first enzyme with a second enzyme that has an enzymatic activity that reverses a modification on the first enzyme and/or for identification of soluble and/or active catalytic domains by systematic variation of fragment lengths around catalytic domain boundaries.... Agent: Foley & Lardner LLP

20090191587 - Method for high-level secretory production of protein: This invention provides a means for enabling high-level secretory production of proteins, in particular proteins having complicated structures such as antibodies, in host cells such as yeast cells. The invention also provides transformed yeast cells having the activated HAC1 gene and the RRBP1 gene and a method for enabling high-level... Agent: Foley And Lardner LLP Suite 500

20090191589 - Process for producing dipeptides: The present invention provides a protein which catalyzes the synthesis of a dipeptide different from L-Ala-L-Ala, a process for producing the protein which catalyzes the synthesis of a dipeptide, a process for producing a dipeptide using the protein which catalyzes the synthesis of a dipeptide, and a process for producing... Agent: Fitzpatrick Cella Harper & Scinto

20090191590 - Signal peptide for producing a polypeptide: The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal peptide and a second nucleotide sequence encoding a polypeptide which is foreign to the first nucleotide sequence. Furthermore, it also relates to... Agent: Novozymes North America, Inc.

20090191588 - Vectors with modified initiation codon for the translation of aav-rep78 useful for production of aav: The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090191592 - Glycoengineered, recombinant antibody: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for... Agent: Sughrue-265550

20090191591 - Taurine transporter gene: The present invention relates to a method of producing a polypeptide, comprising culturing a cell which strongly expresses a taurine transporter and has a transferred DNA encoding a desired polypeptide and thereby allowing the cell to produce the polypeptide. Hamster taurine transporter, a DNA encoding the same, a recombinant vector... Agent: Foley And Lardner LLP Suite 500

20090191593 - Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol: The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2... Agent: Mcdermott, Will & Emery

20090191596 - Alkaline shock-based preparation of nucleic acids: Method of preparing a biological sample appropriate for use in a subsequent in vitro nucleic acid amplification reaction. The method involves a rapid, transient exposure to alkaline conditions which can be achieved by mixing an alkaline solution with a pH-buffered solution that includes a detergent and the biological sample to... Agent: Gen Probe Incorporated

20090191595 - Method for amplification of long nucleic acid: An object of the present invention is to provide a method for amplification of long nucleic acid, wherein the method allows nucleic acid fragments containing the same nucleotide sequence information to efficiently amplify at the same base length. The present invention relates to a method for amplification of long nucleic... Agent: Stanley P. Fisher Reed Smith LLP

20090191594 - Microchemistry reaction method and device: A chemical reaction is conducted in a fluid of a droplet inside a reaction receptacle or on a surface of a reaction substrate. Fluctuations of a magnetic field are applied to the droplet including an aqueous solution having magnetic body particles with a hydrophilic surface, and a physical force is... Agent: Kanesaka Berner And Partners LLP

20090191597 - Enhanced production of infectious parvovirus vectors in insect cells: A method of producing a packaged parvovirus vector, the method comprising: (a) providing an insect cell; (b) introducing into the insect cell one or more vectors comprising nucleotide sequences encoding: (i) a transgene flanked by TRs; and (ii) baculovirus packaging functions comprising Rep components and Cap components sufficient to result... Agent: Moore & Van Allen PLLC

20090191598 - Nucleic acid interaction analysis: The present invention provides at least one isolated linear composite nucleic acid molecule comprising at least one first tag from at least one first nucleic acid molecule and at least one second tag from at least one second nucleic acid molecule, wherein the first and second nucleic acids interact in... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090191541 - Nucleic acid molecules and other molecules associated with plants: The present invention is in the field of plant genetics. More specifically the invention relates to nucleic acid molecules and nucleic acid molecules that contain markers, in particular, single nucleotide polymorphism (SNP) and repetitive element markers. In addition, the present invention provides nucleic acid molecules having regulatory elements or encoding... Agent: Monsanto Company (a&p)

20090191599 - Engineered light-harvesting organisms: The present disclosure identifies pathways and mechanisms to confer photoautotrophic properties to a heterotrophic organism. The resultant engineered cell or organism will uniquely enable efficient conversion of carbon dioxide and light into biomass and carbon-based products of interest.... Agent: Fenwick & West LLP

20090191600 - Method for producing alpha-l-aspartyl-l-phenylalanine-beta-ester and method for producing alpha-l-aspartyl-l-phenylalanine-alpha-methyl ester: A method for producing an α-L-aspartyl-L-phenylalanine-β-ester (also named α-L-(β-o-substituted aspartyl)-L-phenylalanine), which is an intermediate of an α-L-aspartyl-L-phenylalanine-α-methyl ester (also named α-L-aspartyl-L-phenylalanine methyl ester; product name: aspartame), easily, at high yield and inexpensively without going through a complex synthesis method is provided. Further, an easy, inexpensive and high-yield production method for... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090191601 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the ydin gene or the ydib gene or combination thereof: The present invention provides a method for producing an aromatic L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the ydiN gene, the ydiB gene, or both.... Agent: Cermak & Kenealy LLP Acs LLC

20090191602 - Methods and materials for making simvastatin and related compounds: The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.... Agent: Gates & Cooper LLP Howard Hughes Center

20090191603 - Use of rice bran as an accelerant in alcohol fermentation: The present invention relates to a method for production of fermentation-based products, through the fermentation of a carbohydrate substrate in the presence of a microorganism capable of fermentation. The fermentation process may be enhanced through use of a rice bran material as a nutrient source.... Agent: Mcdermott, Will & Emery LLP Attn:IPDepartment

20090191604 - Method for obtaining natural astaxanthin from eggs and gonads of snails: The present invention relates to a process which can effectively extract and purify natural astaxanthin from the eggs and gonads of snails.... Agent: Wpat, PC Intellectual Property Attorneys

20090191605 - Ketoreductase polypeptides for the reduction of acetophenones: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of... Agent: Dechert, LLP

20090191606 - Organic compounds: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1 -ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen... Agent: Novartis Corporate Intellectual Property

20090191607 - Synthetic enzymes derived from computational design: Disclosed herein are techniques for computationally designing enzymes. These techniques can be used to design variations of naturally occurring enzymes, as well as new enzymes having no natural counterparts. The techniques are based on first identifying functional reactive sites required to promote the desired reaction. Then, hashing algorithms are used... Agent: Law Offices Of Ronald M Anderson

20090191608 - Pancreatic islet cell preparation and transplantation: The present invention includes compositions and methods for the preparation of pancreatic islet cells for transplantation.... Agent: Chalker Flores, LLP

20090191610 - Microorganisms with increased efficiency for methionine synthesis: The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090191611 - Methods and compositions for the treatment of gastrointestinal disorders: The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction... Agent: Honigman Miller Schwartz & Cohn LLP

20090191609 - Compositions and methods for enhancing paper product degradation: The present invention describes compositions and methods for enhancing biodegradation of paper products after use and disposal.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090191612 - Biological process for color reduction of pulp and paper effluent: The present invention relates to a bacterium strain of accession no. MTCC 5099, a process for the preparation of inoculum of the said strain, and a process for the reduction of color from pulp mill effluent using the above said inoculum, which comprises steps of inoculating appropriate aliquots of the... Agent: Foley And Lardner LLP Suite 500

20090191613 - Aerobic compost tea making device and method: The device and method invented provides a unique means to extract and multiply, by the millions, beneficial aerobic microbes found in compost and vermicompost to be applied to soil and plants in liquid form. This liquid has been named compost tea colloquially. Compared to many compost tea making devices being... Agent: Timothy J. Wilson

20090191614 - Temperature control device: The present invention relates to a temperature control device, and has an object to accurately control temperatures of microorganisms or cells when for example applied to culture and so on of the microorganisms or cells, for example. The temperature control device includes a plurality of cell parts (2) holding microorganisms... Agent: GlobalIPCounselors, LLP

20090191615 - Device for determining the quality and solidness of the vascular wall: A device for determining the quality and solidness of the vascular wall is provided for testing tissue samples and includes opposed first and second fixation plates. The fixation plates are connectable to an air pump or other source of vacuum for fixing the tissue sample in position. The device is... Agent: Hovey Williams LLP

20090191616 - Biosensor structure and fabricating method thereof: A biosensor structure and a method for fabricating the same are described. The biosensor structure for detecting at least a single cell includes a substrate with an insulating surface, a conductive layer and a plurality of capture molecules. The conductive layer is disposed on the substrate, and has a first... Agent: J C Patents, Inc.

20090191617 - Bio chip and related technologies including apparatus for analyzing biological material: The bio chip and the apparatus for analyzing biological material are disclosed, the bio chip and the apparatus being capable of analyzing a variety of specific materials included in biological materials using a single bio chip injected with a single biological material, capable of conducting an optical measurement and an... Agent: Fish & Richardson P.C.

20090191619 - Method and device for selectively targeting cells within a three-dimensional specimen: The invention provides an apparatus for electromagnetically affecting a particle of interest in a specimen. The apparatus includes (a) a stage capable of supporting the specimen; (b) a detector including at least one camera, wherein the detector is capable of resolving a particle of interest within the specimen; (c) a... Agent: Mcdermott, Will & Emery

20090191618 - Reaction chamber for real time pcr comprising capture probes and permitting detection of the pcr product by hybridisation without opening the pcr vessel: A reaction chamber (1) for real-time PCR configured for containing a PCR solution (3), said chamber having a capture molecule (4) immobilized on the chamber inner surface, said surface being configured to be in intermittent contact with the PCR solution (3), and a window (7) permitting detection of a signal... Agent: Howrey LLP-ca

20090191620 - Limited access multi-layer cell culture system: The present invention provides a multi-layer cell culture device having a rectangular footprint and having multiple cell culture chambers separated by tracheal air spaces, each cell culture chamber having a port and a port cover or an external manifold structured and arranged to allow for transfer of fluid into and... Agent: Corning Incorporated

20090191621 - Cover device for a sample carrier: The present invention relates to a cover device for a sample carrier, comprising a sticky surface area for connection to the sample carrier, wherein the sticky surface area is configured such that the sample carrier is covered in liquid-tight fashion after connection of the cover device to the sample carrier... Agent: Ip Strategies

20090191623 - Compositions and methods for treating hiv infection with cupredoxin and cytochrome c: The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome c551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that... Agent: Don J. Pelto Sheppard, Mullin, Richter & Hampton LLP

20090191622 - Synthetic nucleic acids from aquatic species: A synthetic nucleic acid molecule is provided that includes nucleotides of a coding region for a fluorescent polypeptide having a codon composition differing at more than 25% of the codons from a parent nucleic acid sequence encoding a fluorescent polypeptide. The synthetic nucleic acid molecule has at least 3-fold fewer... Agent: Schwegman, Lundberg & Woessner, P.A.

20090191624 - Use of transthyretin peptide/protein fussions to increase the serum half-life of pharmacologically active peptides/proteins: The present invention provides a means for increasing the serum half-life of a selected biologically active agent by utilizing transthyretin (TTR) as a fusion partner with a biologically active agent. Specifically, the present invention provides substantially homogenous preparations of TTR (or a TTR variant)-biologically active agent fusions and PEG-TTR (PEG-TTR... Agent: Amgen Inc. Law Department

20090191625 - Sirna targeting connective tissue growth factor (ctgf): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20090191627 - Synthetic surfaces for culturing cells in chemically defined media: Synthetic surfaces capable of supporting culture of eukaryotic cells including stem cells and undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a polypeptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition... Agent: Corning Incorporated

20090191626 - Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells: Synthetic surfaces suitable for culturing stem cell derived oligodendrocyte progenitor cells contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived oligodendrocyte progenitor cells in chemically defined media.... Agent: Geron Corporation Attn. David J. Earp

20090191628 - Methods for co-culturing cord blood derived cells with menstrual stem cells: Methods are provided for obtaining expanded human cord blood cells expressing CD34. The methods involve seeding a sufficient amount of cord blood cells with a sufficient amount of menstrual cells under co-culture conditions suitable to promote expansion of the cord blood cells, and co-culturing the cord blood cells with the... Agent: Dilworth Paxson LLP

20090191630 - Dual inhibitors of hiv-1 gp-120 interactions: Compounds, which inhibit the binding of gp120 to CD4 as well as 17b and methods for their use in inhibiting the HIV fusion process, are provided.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20090191629 - Mammalian chemokine reagents: Novel chemokines from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokines. Chemokine receptors are also provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20090191631 - 3-d petri-dish for the culture and studies of cells: A three-dimensional (3-D) culture “Petri-dish” for research in regenerative medicine, biotechnology and clinical translation is described. This 3-D perfusion culture dish is to advance in vitro culture tools from static 2-D to dynamic 3-D perfusion culture. Interwoven hollow fiber capillary membranes divide the “Petri-dish” culture space into a controllable 3-D... Agent: Joerg C. Gerlach

20090191632 - Swellable (meth)acrylate surfaces for culturing cells in chemically defined media: Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and... Agent: Corning Incorporated

20090191633 - Synthetic surfaces for culturing stem cell derived cardiomyocytes: Synthetic surfaces suitable for culturing stem cell derived cardiomyocytes contain acrylate polymers formed from one or more acrylate monomers. The acrylate surfaces, in many cases, are suitable for culturing stem cell derived cardiomyocytes in chemically defined media.... Agent: Geron Corporation Attn. David J. Earp

20090191634 - (meth)acrylate surfaces for cell culture, methods of making and using the surfaces: A synthetic cell culture surface, prepared from a polymerized blend of at least two (meth)acrylate monomers is provided, which supports the growth of undifferentiated human embryonic stem cells in defined media augmented with fetal bovine serum. The cell culture surface forms a uniform layer over the growth area of a... Agent: Corning Incorporated

20090191635 - Plant egg cell transcriptional control sequences: The present invention relates generally to transcriptional control sequences. Generally, the present invention relates to transcriptional control sequences that specifically or preferentially direct expression of a nucleotide sequence of interest in a plant egg cell. The present invention is predicated, in part, on the identification of transcriptional control sequences derived... Agent: Townsend And Townsend And Crew, LLP

20090191636 - Method of producing transgenic graminaceous cells and plants: The present invention provides a method for producing a transgenic graminaceous plant cell, said method comprising: (i) obtaining embryonic cells from a mature graminaceous grain; and (ii) contacting said embryonic cells with a bacterium capable of transforming a plant cell, said bacterium comprising transfer-nucleic acid to be introduced into the... Agent: Cooper & Dunham, LLP

  
07/23/2009 > patent applications in patent subcategories. category listing

20090186333 - Cyclic implant perfusion, cleaning and passivation process and implant produced thereby: This invention is a novel method for perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and... Agent: Gerard H. Bencen Gerard H. Bencent, P.A.

20090186332 - Preparation and storage of stable, antimicrobially active materials: A method for the preparation of antimicrobially active materials is presented. The invention involves taking a base material such as allografts, xenografts, polymers, metals, and ceramics and combining it with an antimicrobially active agent, such as antibiotics, antibacterials, antifungals, antivirals, disinfectants, and polypeptides, after which it is irradiated with ionizing... Agent: The Soni Law Firm

20090186335 - Method of preparing unilamellar vesicles for the cryopreservation and culture of germ cells and embryos: In order to prepare the unilamellar low-density lipid vesicles, a presolution of vegetable lipids is first prepared; a suitable quantity of lipids, between 4 and 12 mg/ml, mixed with pure water, heated and stirred for about 30 minutes; the suspension obtained is kept at 50-60° C. for one hour and... Agent: Ostrolenk Faber Gerb & Soffen

20090186334 - Non-embryonic totipotent blastomere-like stem cells and methods therefor: Human non-embryonic adult totipotent and pluripotent stem cells are isolated in a simplified serum-free and feeder cell-free process. Most remarkably, certain stem cells, and especially BLSCs, are extremely small, fail to exclude trypan blue, but are nevertheless able to proliferate from even high dilutions. Therefore, so obtained stem cells can... Agent: Fish & Associates, PC Robert D. Fish

20090186336 - Immuno-pcr method for detecting nasopharyngeal carcinoma markers and kit thereof: The present invention is related to an immuno-PCR method for detecting nasopharyngeal carcinoma (NPC) and kit thereof, especially related to an immuno-PCR method for detecting markers of early stage NPC and kit thereof. The present invention includes providing a substrate whereon protein markers immobilized; applying a patient's specimen to the... Agent: Bacon & Thomas, PLLC

20090186337 - N protein of a virus of the paramyxoviridae family-protein of interest fusion proteins: The invention relates to N protein-protein of interest fusion proteins, optionally in the form of soluble N protein-protein of interest/P protein complexes, the N and P proteins being proteins of a virus of the Paramyxoviridae family. When the protein of interest is an antigen, the invention relates also to vaccinal... Agent: Stites & Harbison PLLC

20090186338 - Oligonucleotides originating from sequences coding for the surface component of ptlv envelope proteins and their uses: The invention relates to the use of oligonucleotides from the nucleotide sequences coding for the amino-terminal region of the surface component (SU) of envelope proteins of PTLV viruses in order to perform methods of detecting every PTLV strain or PTLV-related viruses, e.g. for the detection of novel PTLV variants or... Agent: Young & Thompson

20090186353 - Cancer-related nucleic acids: Described herein are polynucleotides associated with specific types of cancers. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of various cancers.... Agent: Foley And Lardner LLP Suite 500

20090186363 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Genentech, Inc.

20090186359 - Detecting prostate cancer: An assay for detecting prostate cancer includes reagents for detecting the methylation of GSTP1 and HIC-1 genes.... Agent: Philip S. Johnson Johnson & Johnson

20090186360 - Detection of gstp1 hypermethylation in prostate cancer: An assay for detecting prostate cancer includes reagents for detecting multiple methylation markers from within one gene such as GSTP1.... Agent: Philip S. Johnson Johnson & Johnson

20090186349 - Detection of nucleic acid reactions on bead arrays: The present invention is directed to methods and compositions for the use of microsphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e. the determination of the sequence of nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide... Agent: Mcdermott, Will & Emery

20090186356 - Device and substance for the immobilization of mesenchymal stem cells (mscs): The invention relates to a device comprising at least one surface which comes into contact with biological tissue and/or liquid, which is at least partially coated with a substance which mediates the binding of mesenchymal stem cells (MSCs), a method for the binding and/or isolation of MSCs from biological tissue... Agent: Klarquist Sparkman, LLP

20090186344 - Devices and methods for detecting and quantitating nucleic acids using size separation of amplicons: Devices and methods are described for detecting and quantifying nucleic acids using a sealed system that minimizes contamination. In particular, provided herein are devices for and methods using nucleic acid amplification that permit multiple sampling of an amplification reaction mixture and quantitation and identification of amplicons during the course of... Agent: Cardinal Law Group Caliper Life Sciences, Inc.

20090186352 - Dna conformation: Method of detection or diagnosis of abnormal gene expression in an individual comprising determining in a sample from the individual the presence or absence of a chromosome structure in which two separate regions of the gene have been brought into close proximity, to thereby detect or diagnose whether the individual... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090186362 - Fungal delta-12 desaturase and delta-15 desaturase motifs: The present invention relates to fungal Δ12 desaturases (responsible for conversion of oleic acid to linoleic acid (18:2, LA)) and Δ15 fatty acid desaturases (responsible for conversion of LA to α-linolenic acid (18:3, ALA)). Amino acid motifs diagnostic of Δ12 desaturases and Δ15 desaturases are also provided. Methods of altering... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090186340 - Gene analysis: This invention relates to a series of PCR primers that will allow the simultaneous amplification of regions of the clinically significant ABO and RHD genes.... Agent: Banner & Witcoff, Ltd.

20090186339 - Human transcriptomes: Global gene expression patterns have been characterized in normal and cancerous human cells using serial analysis of gene expression (SAGE). Cancer cell-specific, cell-type specific, and ubiquitously expressed genes have been identified. This information can be used to provide combinations of cell type- and cancer-specific gene probes, as well as methods... Agent: Banner & Witcoff, Ltd.

20090186345 - Instrument and method for nucleic acid isolation: According to the present invention, purified nucleic acids are isolated without the complete removal of components of a washing reagent. Also, nucleic acids are isolated in an elution reagent by allowing a washing reagent comprising at least one component constituting a reaction solution that can be applied to a reaction... Agent: Mcdermott Will & Emery LLP

20090186357 - Integrated pcr reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications: Disclosed are integrated devices capable of performing a polymerase chain reaction within a single vessel. Also disclosed are related methods of sample analysis.... Agent: Woodcock Washburn LLP

20090186347 - Markers for metabolic syndrome: Correlations between polymorphisms and metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Methods of diagnosing and treating metabolic syndrome, insulin resistance, obesity, high blood pressure, dyslipidemia, diabetes and/or myocardial infarction are provided. Systems and kits for diagnosis and treatment of metabolic syndrome, insulin... Agent: Goodwin Procter LLP Attn: Patent Administrator

20090186346 - Method for detecting the presence or absence of a target cell in a sample: The present invention relates to a method for detecting the presence or absence of a target cell in a sample, said method comprising (a) binding cells in said sample to a particulate and mixable solid support; (b) eluting the cells from the solid support without the use of competitor molecules... Agent: Crowell & Moring LLP Intellectual Property Group

20090186355 - Method for determination and quantification of radiation or genotoxin exposure: The present invention discloses methods for detecting exposure of a living subject to genotoxic agents, testing sensitivity to a genotoxic agent, and determining DNA damage caused by exposure to an agent, comprising detecting the presence of FANCD2-containing foci from a sample collected from said subject. The presence of concentrated foci... Agent: Edwards Angell Palmer & Dodge LLP

20090186354 - Methods and tools for the screening of factors affecting protein misfolding: The present invention relates in general to the fields of chemical, pharmaceutical and genetic screening and to diseases associated with protein misfolding. In particular, it discloses engineered cells and a system based thereon that can be used to screen for substances that affect protein misfolding. The engineered cells of the... Agent: Clark & Elbing LLP

20090186343 - Methods for preparing modified biomolecules, modified biomolecules and methods for using same: A novel and efficient single pot synthetic schemes are disclosed for preparing modified nucleotides, nucleotide analogs, nucleotide polyphosphates, and nucleotide polyphosphate analogs. The novel method is used to prepare nucleotides, nucleotide analogs, nucleotide polyphosphates, and nucleotide polyphosphate analogs having non-persistent or persistent and non-persistent modifications. Novel biomolecular reactions are also... Agent: Invitrogen Corporation C/o Intellevate

20090186361 - Methods of predicting the pharmaceutical toxicity of taxanes: The present disclosure relates to methods of identifying a recipient subject who has an elevated risk of an adverse or toxic reaction to a taxane. The predictive methods of the present disclosure allow for the recipient subject most at risk of adversely reacting to the taxane, to be administered alternative... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20090186342 - Methods of producing competitive aptamer fret reagents and assays: Methods are described for the production and use of fluorescence resonance energy transfer (FRET)-based competitive displacement aptamer assay formats. The assay schemes involve FRET in which the analyte (target) is quencher (Q)-labeled and previously bound by a fluorophore (F)-labeled aptamer such that when unlabeled analyte is added to the system... Agent: Loeffler Jonas & Tuggey, LLP

20090186348 - Micrornas differentially expressed in cervical cancer and uses thereof: The present invention concerns methods and compositions for identifying a miRNA profile for a particular condition, such as cervical disease, and using the profile in assessing the condition of a patient.... Agent: Fullbright & Jaworski L.L.P.

20090186350 - Muitiforms suspension microgranular bioreactor and methods of use: A Multiform Suspension Microgranular Bioreactor (MSMB) is used to detect nucleic acids or peptides/proteins in molecular and biological samples. Polymer-based microgranules, coupled with biomass molecule probes, are constructed with different features. The biomass molecule probes include cDNA probes, oligonucleic acid probes, peptide or protein probes. These microgranules are differentiated according... Agent: Limin Wen

20090186351 - Nucleotide analogs: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090186358 - Pathway analysis of cell culture phenotypes and uses thereof: The present invention provides methods for systematically identifying genes, proteins and/or related pathways that regulate or indicative of cell phenotypes. The present invention further provides methods for manipulating the identified genes, proteins and/or pathways to engineer improved cell lines and/or to evaluate or select cell lines with desirable phenotypes.... Agent: Choate, Hall & Stewart LLP

20090186341 - Receptacle for the separation of tumor cells: The invention describes a container (1) for separating tumour cells, in particular disseminated tumour cells (9), from a biological sample, with a closed end and an end which can be opened (2, 3). It contains a thixotropic substance (4) with a specific density selected from a range with a lower... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20090186364 - Method of constructing recombinant proteoliposome for diagnostic use: [PROBLEM-SOLVING MEANS] Recombinant proteoliposomes are prepared by fusion of budded virus particles of a recombinant baculovirus, expressing a target membrane receptor (such as human thyroid-stimulating hormone receptor, acetylcholine receptor, insulin receptor, β1 adrenergic receptor, asialoglycoprotein receptor, etc., each participating in an autoantibody-related disease), with liposomes. Compared with the recombinant baculoviruses,... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090186366 - Method of detecting interactions between protein components: A method of detecting protein interactions in a biological sample. Protein components in a first aliquot of a sample are labelled with a first bifunctional dye which cross-links any-interacting components. A second aliquot of said sample functions as a control sample, in which protein components are labelled with a different,... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20090186365 - Use of 14-3-3- proteins in treatment and prevention of neurodegeneration: The present disclosure is directed to methods for treatment and prevention of disease states characterized by a decreased 14-3-3 polypeptide expression or activity. In one embodiment, the present disclosure provides methods for the treatment and/or prevention of Parkinson's disease, neurodegeneration and/or diseases characterized, at least in part, by neurodegeneration, by... Agent: Bradley Arant Boult Cummings LLP Intellectual Property Department

20090186367 - Diagnosis of fertility conditions using a serine protease: The present invention relates to a method of diagnosing an infertility condition in a human female subject, the method comprising detecting pregnancy-related serine protease (PRSP) protein in a test sample taken from said subject at between 7 and 20 weeks into pregnancy; detecting PRSP protein in a test sample from... Agent: Klauber & Jackson

20090186368 - Assay with reduced background: In an assay, an analyte in a sample is contacted with a thermostable reporter adenylate kinase coupled to a binding agent specific for the analyte, wherein a complex is formed. ADP is added, and then formation of ATP is monitored. Prior to the addition of ADP, endogenous kinase and uncomplexed... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090186369 - Polysaccharide-protein binding model and nano-fibril formation of a starch binding domain: The present invention relates to a polysaccharide-protein binding model of SBD, and a fibril-forming 14-residue peptide consisting of X1NNNX2X3NYQX4X5X6X7X8, wherein the X1 and X8 mean a pair of opposite charged amino acid residues, and the X2, X3, X4, X5, X6, or X7 means an amino acid residue. The present invention... Agent: Wpat, PC Intellectual Property Attorneys

20090186370 - Diagnostic biomarkers for vascular aneurysm: Biomarkers for diagnosis and monitoring of vascular aneurysms are described in the context of the use of assays to measure a plurality of these biomarkers. Tissue degeneration, particularly elastin and/or collagen degradation, can be monitored within patient blood (serum) and/or urine to diagnose the presence, the progression, or the likelihood... Agent: Dardi & Associates, PLLC US Bank Plaza

20090186371 - Method for determination of inflammatory bowel disease: o

20090186372 - Reagent compositions for use in electrochemical detection: Biological reagent compositions with improved sensitivity to the concentration of blood glucose in patient samples for use in measuring systems and methods. The reagent compositions comprise a glucose oxidoreductase enzyme, a flavin nucleoside coenzyme and a mediator formulation. The mediator formulation comprises at least one electroactive organic molecule and at... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090186374 - Apparatus for measuring effect of test compounds on biological objects: An apparatus and method for real-time measurement of an effect of different concentrations of a test compound or series of test compounds on living cells, in which a flow of cell suspension is combined with a flow of the test compound and a cellular response of the living cells is... Agent: Knobbe Martens Olson & Bear LLP

20090186375 - Method for determining bioactivity of molecules: The present invention relates to a method for determining activity of a molecule, wherein the molecule comprises at least two active parts, and wherein the first part is capable of modulating the activity of cells, and the second part can specifically bind to a target, and kits useful for performing... Agent: Millen, White, Zelano & Branigan, P.C.

20090186373 - Pyrimidines reacting with o6-alkylguanine-dna alkyltransferase: wherein R1 is hydrogen, lower alkyl, halogen, cyano, trifluoromethyl or azido; R2 is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring a label from pyrimidines of formula (I) to O6-alkylguanine-DNA alkyltransferases (AGT) and AGT fusion... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090186376 - Svegfr-2 and its role in lymphangiogenesis modulation: Disclosed herein are nucleic acid molecules comprising a nucleotide sequence of sVEGF-2, proteins encoded by those sequences and antibodies that bind to the protein. Also disclosed are methods for inhibiting or enhancing expression or activity of sVEGFR-2 and methods for inhibiting graft rejection, particularly cornea graph rejection. Also described are... Agent: Crowell & Moring LLP Intellectual Property Group

20090186377 - Modifications of cst-ii for increased protein expression: The present invention provides modified Campylobacter sialyltransferase proteins that exhibit enhanced expression as compared to its unmodified form. Nucleic acids that encode the sialyltransferase proteins are also included, as are methods to produce and use the sialyltransferase proteins.... Agent: Townsend And Townsend And Crew, LLP

20090186381 - Cellulase variants with reduced inhibition by glucose: A Family 6 cellulase variant enzyme comprising one or more than one amino acid substitution selected from a basic, polar or non-polar amino acid at position 103, a valine or isoleucine at position 136, a tyrosine at position 186, a glutamic acid or glutamine at position 365 and a glutamine... Agent: Fitzpatrick Cella Harper & Scinto

20090186379 - Erk ligands and polynucleotides encoding erk ligands: The invention relates to kinase inhibitor ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate ERK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090186380 - Method of secretory expression of lysostaphin in escherichia coli at high level: A method of secretory expression of lysostaphin in Escherichia coli at high level, which comprises constructing a expression vector by cloning a sequence encoding a signal peptide which is suitable for secretory expression in Escherichia coli before part or whole gene sequence which encodes mature lysostaphin, and ligating the cloned... Agent: Clausen Miller, P.c

20090186378 - Polynucleotides encoding the fkbb gene of the fk-520 polyketide synthase gene cluster: Host cells comprising recombinant vectors encoding the FK-520 polyketide synthase and FK-520 modification enzymes can be used to produce the FK-520 polyketide. Recombinant DNA constructs comprising one or more FK-520 polyketide synthase domains, modules, open reading frames, and variants thereof can be used to produce recombinant polyketide synthases and a... Agent: Morrison & Foerster LLP

20090186382 - Preparation of romidepsin: The invention provides an improved process for preparing romidepsin. The process involves producing, purifying, or storing romidepsin under conditions that prevent the formation of undesired adducts. Purifying romidepsin at an apparent pH lower than approximately 6.0 (e.g., between an apparent pH of 4.0 and 6.0) has been discovered to prevent... Agent: Choate, Hall & Stewart LLP

20090186383 - Method of extracting starches and sugar from biological material using controlled cavitation: A method of extracting sugar, starch, and/or carbohydrates from feed material such as corn or corn stover is disclosed. The feed material is mixed with liquid and perhaps accelerants to form a mixture. The mixture is pumped through a controlled cavitation reactor, where it is exposed to shockwaves from cavitation... Agent: Womble Carlyle Sandridge & Rice, PLLC

20090186384 - Purine-derived substance-producing bacterium and a method for producing purine-derived substance: A purine-derived substance is produced by culturing a Bacillus bacterium which has an ability to produce a purine-derived substance and has enhanced activity of an enzyme of the oxidative pentosephosphate pathway. The purine-derived substance is produced in the medium or the bacterial cells, and can be collected from the medium... Agent: Cermak & Kenealy LLP Acs LLC

20090186385 - Recombinational cloning using nucleic acids having recombination sites: Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have the desired characteristic(s) and/or DNA segment(s).... Agent: Invitrogen Corporation C/o Intellevate

20090186386 - Recombinational cloning using nucleic acids having recombination sites: Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have the desired characteristic(s) and/or DNA segment(s).... Agent: Invitrogen Corporation C/o Intellevate

20090186387 - Recombinational cloning using engineered recombination sites: Recombinational cloning is provided by the use of nucleic acids, vectors and methods, in vitro and in vivo, for moving or exchanging segments of DNA molecules using engineered recombination sites and recombination proteins to provide chimeric DNA molecules that have the desired characteristic(s) and/or DNA segment(s).... Agent: Invitrogen Corporation C/o Intellevate

20090186388 - Lactic acid bacterium capable of producing y-aminobutyric acid: The present invention provides a lactic acid bacterium which can produce γ-aminobutyric acid (GABA) even under a coexisting condition of lactic acid and common salt in a medium at time of commencement of culturing, and a method for producing a culture mixture comprising GABA. Specifically, a culture mixture comprising GABA... Agent: Greenblum & Bernstein, P.L.C

20090186389 - Microorganism whose activity of aspartate semialdehyde dehydrogenase is enhanced and the process for producing l-threonine using the microorganism: The present invention relates to a microorganism producing L-threonine with increased L-threonine production efficiency by the increased activity of aspartate semialdehyde dehydrogenase in L-threonine biosynthesis pathway,... Agent: Swanson & Bratschun, L.L.C.

20090186390 - Method for the production of modified steroid degrading microorganisms and their use: A method is described to construct genetically modified strains of steroid degrading micro-organisms wherein the method comprises inactivation of at least one gene involved in methylhexahydroindanedione propionate degradation. Strains with (multiple) inactivated steroid degrading enzyme genes according to the invention can be used in the accumulation of steroid intermediates. Accumulation... Agent: Organon Usa, Inc. C/o Schering-plough Corporation

20090186391 - Method for production of erythro-or threo-2-amino-3-hydroxypropionic acid ester, novel carbonyl reductase, gene for the reductase, vector, transformant, and method for production of optically active alcohol using those: The present invention has its object to provide a method of producing an erythro- or threo-2-amino-3-hydroxypropionic acid ester, and so forth. The present invention relates to: a method of asymmetrically reducing an N-2-amino-3-oxopropionic acid ester by allowing cells of a microorganism to act thereon; a polypeptide having an activity of... Agent: Birch Stewart Kolasch & Birch

20090186392 - Anaerobic fermentation of glycerol: The invention relates to the development of appropriate cultivation conditions for a bacteria to grow anaerobically (fermentatively) on a glycerol substrate. The method requires culturing bacteria having a functional 1,2-propanediol pathway and a functional type II glycerol dehydrogenase-dihydroxyacetone kinase pathway in a culture medium containing high concentrations of glycerol, a... Agent: Baker & Mckenzie LLP

20090186393 - Nanolipoprotein particles comprising hydrogenases and related products, methods and systems: Provided herein are nanolipoprotein particles that comprise a membrane associated hydrogenase and related assemblies, devices, methods and systems.... Agent: Llnl/steinfl & Bruno John H. Lee, Assistant Laboratory Counsel

20090186394 - Crystallizable jnk complexes: The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of JNK3. A computer comprising such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as... Agent: Ropes & Gray LLP

20090186395 - Virus removal by nanofiltration: A method for purifying a protein solution from infective particles comprising (a) adding a macromolecule to the solution; and (b) passing the solution through a nanofilter. The macromolecule may be selected from a polymer of at least 3 monomers of sugars, amino acids, glycols, alcohols, lipids or phospholipids.... Agent: The Nath Law Group

20090186396 - Enhanced purification of phosphorylated and nonphosphorylated biomolecules by apatite chromatography: Methods are disclosed for the use of apatite chromatography, particularly without reliance upon phosphate gradients, for fractionation or separation of phosphorylated and nonphosphorylated biomolecules. Integration of such methods into multi-step procedures, with other fractionation methods are additionally disclosed.... Agent: Pillsbury Winthrop Shaw Pittman LLP

20090186397 - Product: The invention relates to a microorganism growth substrate which comprises a sterile nutrient composition derived from the biomass of a culture of bacteria including methanotrophic bacteria and further containing at least one sterile nutrient. A preferred biomass material is that derived from a microbial culture comprising Methylococcus capsulates (Bath) (strain... Agent: Sughrue Mion, PLLC

20090186398 - Increased bacterial coa and acetyl-coa pools: Methods of increasing the cellular pool of A-CoA and thus driving the metabolic pathways in the direction of A-CoA containing metabolites by overexpressing rate limiting enzymes in A-CoA synthesis. Methods of increasing intracellular levels of CoA and A-CoA through genetic engineering of bacterial strains in conjunction with supplementation with precursor... Agent: Baker & Mckenzie LLP

20090186399 - Streptomyces strain and the method of converting ferulic acid to vanillin by using the same: A method of vanillin production from ferulic acid with a high concentration by biotransformation using a Streptomyces sp. strain is claimed in this invention. This strain is named as Streptomyces sp. V-1, which has been deposited in China Center for Type Culture Collection on Jul. 12, 2006 with the number... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090186400 - Method of producing s-adenosyl-l-methionine-containing dry yeast having excellent storage stability, the product thereof and composition for oral intake: A method for producing a dry yeast containing S-adenosyl-L-methionine using a yeast having production capability of S-adenosyl-L-methionine, in which an ascorbic acid compound or a salt thereof is added to a yeast concentrate separated from a fungus culture liquid of the yeast, and the concentrate is then dried, a dry... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090186401 - Lid for pcr vessel comprising probes permitting pcr amplification and detection of the pcr product by hybridisation without opening the pcr vessel: The present invention proposes a simple and effective lid being part of a device having multiwells for performing simultaneous amplifications by PCR and detections of multiple target molecules on unlabeled capture molecules immobilized on the lid.... Agent: Howrey LLP-eu

20090186403 - Biochip cartridge: The biochip cartridge comprises a tabular substrate member formed using an elastic material and a flexible cover airtightly attached to the surface of the substrate member, wherein at least an area for storing biopolymers, an area for detecting desired biopolymers from the biopolymers that have been preprocessed, and a flow... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20090186402 - Detection instrument with the use of polynucleotides mapped on barley chromosome: As the results of mass sequencing of cDNA clones originating in barley varieties “H. spontaneum”, “Haruna Nijo” and “Akashinriki”, a large number of sites showing single nucleotide polymorphisms (SNPs) among the varieties are found out. Because of involving nonsynonymous substitutions and likely relating to phenotypes inherent in respective varieties, these... Agent: Nixon & Vanderhye, PC

20090186404 - Apparatus for amplifying nucleic acids: Provided is a nucleic acid amplifying apparatus having a uniform distribution of reaction temperature in a reaction space. The nucleic acid amplifying apparatus includes a substrate providing a polymerase chain reaction (PCR) space, and a plurality of heating units disposed above or below the reaction space to transfer heat to... Agent: Marger Johnson & Mccollom, P.C.

20090186405 - Rapid chilling device for vitrification: Successful cryopreservation by the vitrification method depends on high chilling speed. Practitioners of vitrification prefer to use liquid nitrogen as the chilling cryogen due to its inherent safety and low cost. Plunging vitrification cryocontainers in to a quiescent pool of liquid nitrogen invariably results in a chilling rate less than... Agent: Mark S. Nowotarski

20090186406 - Dre recombinase and recombinase systems employing dre recombinase: The invention provides a Dre/rox recombinase system. In particular, the invention provides Dre polypeptides that can catalyze site-specific recombination at rox sites but not at lox sites. The Dre/rox system can be utilized in a number of genetic manipulations either alone or in combination with other recombinase systems.... Agent: Bryan Cave LLP

20090186407 - Alternative compositions and methods for the culture of stem cells: Methods and cell culture medium for the generation and maintenance of human pluripotent embryonic stem cells are disclosed. Human embryonic stem cells are cultured with human feeder cell conditioned medium, and the embryonic stem cells maintain their pluripotent phenotype. The human pluripotent embryonic stem cells can be cultured without feeder... Agent: Sutherland Asbill & Brennan LLP

20090186408 - Biocompatible bilayer porous matrix and preparation thereof: The present invention provides a biocompatible bilayer porous matrix and preparation thereof. The bilayer porous matrix is composed of gelatin, chondroitin 6 sulfate, and hyaluronic acid, also, prepared through freeze-drying technique at different temperature and time duration to form varied pore sizes on each layer. The present invention also provides... Agent: Bacon & Thomas, PLLC

20090186409 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Genentech, Inc.

20090186410 - Rna silencing compositions and methods for the treatment of huntington's disease: The present invention relates to the discovery of an effective treatment for a variety of Huntington's disease (HD). The present invention utilizes RNA silencing technology (e.g. RNAi) against single nucleotide polymorphisms (SNPs) in the Huntingtin (htt) gene encoding the dominant, gain-of-function mutant Huntington protein, thereby resulting in an effective treatment... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090186411 - Cell culture apparatus, method for producing the apparatus and cell culture method: The invention relates to a cell culture apparatus for cells, characterized by a surface composed of an unstructured elastomer. It is thus possible for cells to be cultured under close to natural conditions in relation to their environmental elasticity. A method for producing an apparatus according to the invention is... Agent: Jordan And Hamburg LLP

20090186412 - Porous cell scaffold and production method thereof: For easily seeding cells in its scaffold, a porous cell scaffold is produced by steps of filling a guiding solution with kinematic viscosity being 50 to 450% of that of a culture medium, in a whole continuous small hole structure having hole diameters of 5 to 3200 μm and an... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090186414 - Methods of generating cardiomyocytes and cardiac progenitors and compositions: The present disclosure provides methods of inducing cardiomyogenesis in a stem cell or progenitor cell, or in a population of stem cells or progenitor cells; and methods for expansion of (increasing the numbers of) cardiac progenitors. Cell compositions are also provided.... Agent: Bozicevic, Field & Francis LLP

20090186413 - Mussel adhesive protein as gene delivery: The present invention is related to a composition and a method for delivering a nucleic acid into a cell. The invention also provides a biocompatible and biodegradable gene delivery composition and methods of use and making thereof.... Agent: LexyoumeIPGroup, LLC

20090186415 - Method for production of cytochrome p450 with n-terminal truncated p450 reductase: The present invention provides a P450 reductase lacking N-terminal amino acids, as well as a nucleic acid encoding the P450 reductase. When co-expressed with a cytochrome P450, the P450 reductase increases the activity and/or expression of the cytochrome P450 compared to the activity and/or expression of the cytochrome P450 when... Agent: Elmore Patent Law Group, PC

  
07/16/2009 > patent applications in patent subcategories. category listing

20090181357 - Method of freeze-drying sterilized rumen fluid to maintain the bioactivity of the bacterial polysaccharides: A method of freeze-drying rumen fluid while retaining the activity of the contained bacterial polysaccharides is described. The resulting product may be formulated into nutritional compositions including probiotics, nutricines, vitamins, minerals, an amino acid, and/or a monosaccharide. The use of this resulting nutritional composition the first few days of young... Agent: Robert Terrell Winn

20090181358 - Marker for chromosomal abnormalities: Provided are methods of determining whether a pregnant woman is at elevated risk for carrying a fetus with a chromosomal abnormality. Also provided are kits for determining whether a pregnant woman is at elevated risk for carrying an aneuploid fetus.... Agent: Craig J Arnold Amster Rothstein & Ebentein

20090181362 - Method for determination of recognition specificity of virus for receptor sugar chain: A method is provided in which the recognition specificity of a virus for a receptor sugar chain can be easily determined with a simple instrument or apparatus. This method for determining the recognition specificity of a virus for a receptor sugar chain or for determining the change in a host... Agent: Winston & Strawn LLP Patent Department

20090181359 - Method of performing ultra-sensitive immunoassays: A method for improving the sensitivity of an immunoassay by a factor of at least 10 to about 25, and perhaps greater. Furthermore, in addition to increasing the sensitivity of the assay, the method of this invention also improves assay specificity. In order to match or improve upon sensitivity of... Agent: Paul D. Yasger Abbott Laboratories

20090181360 - Multiplex detection assay for influenza and rsv viruses: The present invention generally relates to a molecular test of Influenza A, Influenza B, Respiratory Syncytial Virus A, and Respiratory Syncytial Virus B in order to identify patients with a viral infection. Accordingly methods and compositions are disclosed to determine the presence or absence of a viral pathogen in a... Agent: Foley & Lardner LLP

20090181363 - Non-invasive detection of fish viruses by real-time pcr: A real-time assay coupled with a non-invasive tissue sampling was developed for the detection and quantification of fish viruses. As a proof of principles, data were presented for the detection and quantification of infectious hypodermal necrosis virus (IHNV) in trout. The primers were designed for IHNV nucleocapsid (N), and surface... Agent: Moore & Van Allen PLLC

20090181365 - Norovirus detection reagent: The present invention provides a combination of oligonucleotides preferable for composing a gene testing reagent capable of detecting all subtypes of norovirus rapidly and with high sensitivity. More specifically, the present invention provides a detection method in which only norovirus is specifically amplified and an oligonucleotide that binds to a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090181361 - Rapid test for detecting infection: A rapid test kit has a cellulose filter paper with a flow rate selected in a range of about 0.04 to about 0.4 ml/min/cm2, such that rapid screening for disease or other conditions amendable to detection of antibodies or antigens may be made using bodily fluids, such as blood, serum... Agent: Christopher Paradies, Ph.d.

20090181364 - Zinc binding compounds and their method of use: The present invention provides a metal chelator and methods that facilitate binding, detecting, monitoring and quantitating of zinc ions in a sample. The metal chelating moiety of the zinc-binding compound is an analog of the well-known calcium chelator, BAPTA (1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid), wherein the chelating moiety has been modified from a... Agent: Invitrogen Corporation C/o Intellevate

20090181386 - Calving characteristics: The invention relates to a method for determining calving characteristics in bovine subjects, wherein calving characteristics comprise stillbirth, calving difficulty and calf size at birth, which are all economically important factors. In particular, the method of the invention involves identification of genetic markers and/or Quantitative Trait Locus (QTL) for the... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20090181383 - Cancer risk biomarker: The present disclosure relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular cancer or predisposition to cancer. Also provided are methods and compositions for identifying a greater risk for a cancer-related condition in an subject.... Agent: Wilson Sonsini Goodrich & Rosati

20090181376 - Compositions and processes for improved mass spectrometry analysis: The invention provides a novel additive for improved analysis by mass spectrometry. More specifically, ascorbic acid has been found to reduce or eliminate the presence of adducts commonly present in mass spectra. The improved processes and compositions of the invention allow for increased accuracy, sensitivity and throughput for samples analyzed... Agent: Grant Anderson LLP C/o Portfolioip

20090181401 - Detection format for hot start real time polymerase chain reaction: The present invention is directed to a method and a composition for amplifying and detecting a target nucleic comprising subjecting said target nucleic acid to a real time PCR amplification reaction in the presence of a thermostable DNA polymerase, a thermostable double strand dependent 3′-5′ exonuclease having a temperature optimum... Agent: Marilyn L. Amick Roche Diagnostics Operations, Inc.

20090181395 - Detection of antibiotic-resistant microorganisms: Method of detecting methicillin-resistant S. aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) in a nucleic acid coamplification assay. The invention advantageously reduces the incidence of false-positive MRSA determinations in real-time assays by requiring satisfaction of a threshold criterion that excludes certain co-infections from the MRSA determination. The invention further provides... Agent: Gen Probe Incorporated

20090181367 - Diagnosis of sepsis using mitochondrial nucleic acid assays: The invention provides assays to detect sepsis disease states in a subject by determining the relative amount of mitochondrial nucleic acid in the subject. The assays of the invention may include PCR assays, such semi-quantitative or quantitative PCR involving the co-amplification of a mitochondrial sequence and a reference sequence, such... Agent: Jeffrey J. King, Esq. Black Lowe & Graham PLLC

20090181394 - Diagnostic methods and kits for hepatocellular carcinoma using comparative genomic hybridization: The invention provides diagnostic methods for determining the prognosis of hepatocellular carcinoma (HCC) comprising the steps of (a) observing recurrently altered genomic region on a chromosome; (b) measuring variation of one or more of RAR expression variations selected from the RAR variation group consists of gains of RAR-G1 to RAR-G14... Agent: Clark & Elbing LLP

20090181374 - Direct atp release sequencing: A method for sequencing a nucleic acid is provided. In certain embodiments, the method includes contacting a nucleic acid duplex comprising a nucleic acid template and a primer annealed to the template with a reagent mix under primer extension conditions to produce an extended primer and ATP. The reagent mix... Agent: Agilent Technologies Inc.

20090181373 - Dna methylation specific signal amplification: This invention is related to a method for rapidly detecting gene specific methylation through signal amplification using the epi-barcode after hybrid capture of the methylated DNA sequence.... Agent: Weiwei. Li

20090181388 - Enclosed unit for rapid detection of a target nucleic acid amplification product: The invention relates to a method for rapid detection of a target nucleic acid amplification product while preventing cross-contamination between target nucleic acid amplification products and avoiding false positives, comprising the steps of: a) leaving the reaction tube unopened after the amplification reaction is finished, so as to prevent the... Agent: G Kenneth Smith

20090181380 - Genemap of the human genes associated with crohn's disease: The present invention relates to the selection of a set of polymorphism makers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility... Agent: Ralph A. Dowell Of Dowell & Dowell P.C.

20090181390 - High throughput detection of micrornas and use for disease diagnosis: Methods, compositions and kits are provided for high throughput detection of micro RNAs (miRNA), especially for sensitive and specific detection of miRNA that are in low abundance and closely related to each other. In particular, an assembly of designed oligonucleotide probes with unique tag sequences is used to achieve these... Agent: Wilson Sonsini Goodrich & Rosati

20090181377 - Human ribosomal dna (rdna) and ribosomal rna (rrna) nucleic acids and uses thereof: Provided herein are isolated nucleic acids that comprise a human rRNA or rDNA subsequence and related compositions and methods of use.... Agent: Morrison & Foerster LLP

20090181399 - Insect resistant coton plants and methods of detecting the same: The present application relates to an insect resistant transgenic cotton event designated COT202. The application also relates to polynucleotides which are characteristic of the COT202 event, plants comprising said polynucleotides, and methods of detecting the COT202 event.... Agent: Syngenta Biotechnology, Inc. Patent Department

20090181366 - Internal positive control for nucleic acid assays: Compositions and methods for detecting a non-specific nucleic acid amplification inhibitor in a reaction are disclosed. An internal positive control (IPC) may be included in samples to be tested for target nucleic acids as a means to monitor non-specific inhibition of nucleic acid amplification and provide confidence in negative results... Agent: Foley & Lardner LLP

20090181372 - Method and compositions for monitoring dna binding molecules in living cells: The present invention provides a method of screening for a compound that binds to a selected nucleic acid comprising contacting compound fluorescently labeled by a fluorescent protein with a cell having a plurality of copies of the nucleic acid in an array such that the nucleic acid can be directly... Agent: Mandel & Adriano

20090181387 - Method for analysing nucleic acids: Method of analyzing nucleic acids comprising the steps of nucleic acid fractionation, adaptor binding and nucleic acid amplification, and an in vitro transcription step. The invention has application in the field of genomic analysis of organisms by the use of DNA microarrays.... Agent: Traskbritt, P.C.

20090181375 - Method for detection of nucleic acid barcodes: A method of sample analysis is provided. In certain embodiments, the method may comprise: a) contacting a surface-tethered oligonucleotide with a sample comprising a barcode oligonucleotide to produce an oligonucleotide duplex comprising a double-stranded surface-proximal region and a single-stranded surface-distal overhang; b) extending the barcode oligonucleotide using the overhang as... Agent: Agilent Technologies Inc.

20090181370 - Method for sequencing a polynucleotide template: The invention relates to methods for pairwise sequencing of a double-stranded polynucleotide template, which permit the sequential determination of nucleotide sequences in two distinct and separate regions on complementary strands of the double-stranded polynucleotide template. The two regions for sequence determination may or may not be complementary to each other.... Agent: Klauber & Jackson

20090181368 - Method of detecting mycoplasma: An object of the present invention is to provide a primer capable of detecting a mycoplasma A. laidlawii (Acholeplasma laidlawii) sensitively and specifically. In order to achieve this object, the primer of the present invention is a primer for detecting A. laidlawii and for amplifying at least either one of... Agent: Darby & Darby P.C.

20090181400 - Method of detection of prostate cancer: The present invention provides methods and kits useful for detecting neplasia by measuring the methylation level of biomarkers, especially the promoter region of GSTP1 for the detection of prostate adenocarcinoma.... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper LLP (us)

20090181371 - Methods and compositions related to a braf mutation and microsatellite stability: Disclosed are methods and compositions related to a BRAF mutation and microsatellite stability.... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20090181396 - Methods and systems for analysis of fluorescent reactions with modulated excitation: Methods, systems and their components for monitoring fluorescent signals and particularly transient fluorescent signals from reaction mixtures of interest, which methods and systems employ modulated excitation light sources to reduce impacts of excessive illumination on the reaction components or the data obtained therefrom.... Agent: Pacific Biosciences Of California, Inc.

20090181391 - Methods for analysis of dna methylation percentage: Methods are disclosed for determining the methylation state of DNA samples using melt analysis including high resolution melt analysis. Methods are also provided for determining methyltransferase activity using melt analysis including high resolution melt analysis. Additionally, kits of parts are provided.... Agent: Claypool Intellectual Property

20090181393 - Methods for the identification, assessment, and treatment of patients with proteasome inhibition therapy: The present invention is directed to the identification of markers that can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to treatment. In particular, the present invention is directed to the use of certain combinations of markers, wherein the expression... Agent: Millennium Pharmaceuticals, Inc.

20090181369 - Methods for the treatment of disease: The present invention is directed to methods to determine the likelihood of therapeutic effectiveness of a farnesyl transferase inhibitor (FTI). The method comprises determining whether the gene encoding the farnesyl transferase beta subunit (FNTB) of said patient comprises at least one nucleic acid variance that causes an alteration in an... Agent: David S. Resnick

20090181379 - Molecular markers of hepatocellular carcinoma and their applications: By means of a proteomic approach, the markers of hepatocellular carcinoma (HCC) in the liver of a knockout mouse (MAT1A−/−) have been identified for the MAT1A gene (deficient in the synthesis of S-adenosylmethionine). 27 proteins have been detected the expression thereof is altered in, at least, 50% of the analysed... Agent: Moore & Van Allen PLLC

20090181398 - Nanoparticle conjugates: Conjugate compositions are disclosed that include a specific-binding moiety covalently coupled to a nanoparticle through a heterobifunctional polyalkyleneglycol linker. In one embodiment, a conjugates is provided that includes a specific-binding moiety and a fluorescent nanoparticle coupled by a heterobifunctional PEG linker. Fluorescent conjugates according to the disclosure can provide exceptionally... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20090181378 - Nucleic acid detection combining amplification with fragmentation: Provided herein are methods and compositions for detection of a nucleic acid target in a sample. The methods and compositions use primer directed amplification in conjunction with nucleic acid fragmentation. The methods have high sensitivity even in the presence of a large amount of non-target nucleic acid. Also provided are... Agent: Foley & Lardner LLP

20090181397 - Predictive and diagnostic methods for cancer: The present disclosure encompasses methods of diagnosing the presence of a cancer, and particularly a cancer of prostate or breast tissue, in a human subject, predicting the outcome or severity of the disease and methods of reversing the prostate cell transformation based on the presence or absence in the human... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20090181384 - Prognosis prediction for colorectal cancer: This invention relates to prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for colorectal cancer. Specifically, this invention relates to the use of genetic markers for the prediction of the prognosis of cancer, such as colorectal cancer, based on signatures of genetic... Agent: Borson Law Group, PC

20090181389 - Quantitative measurement of nucleic acid via ligation-based linear amplification: Methods, compositions and kits are provided for sensitive and quantitative detection of nucleic acid, especially for the determination of the presence and/or amount of a target nucleic acid with mutations or single nucleotide polymorphism (SNP). In particular, assays are provided for amplifying a target nucleic acid via ligation of designed... Agent: Wilson Sonsini Goodrich & Rosati

20090181385 - Reagents, methods, and libraries for bead-based sequencing: The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of extension, ligation, and, preferably, cleavage. In certain embodiments the methods make use of extension probes containing phosphorothiolate linkages and employ agents appropriate... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090181382 - Sphingosine 1-phosphate receptor gene, sppr: A novel sphingosine 1-phosphate receptor gene, herein termed sppr, and its splice variants. Sppr is up-regulated in LGL and is useful, for example, in the diagnosis and treatment of certain lymphoproliferative, neurodegenerative and autoimmune diseases.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090181381 - Systems and methods for electronic detection with nanofets: There is disclosed a system for electrical charge detection comprising a nanoFET device. Also disclosed is a method of electrical charge detection for single molecule sequencing. The method includes attaching a macromolecule or assemblies thereof to a gate of a nanoFET device and flowing in a solution of charge tags,... Agent: Mh2 Technology Law Group, LLP

20090181392 - Transgenic zebrafish models for neurodegenerative diseases: The present invention relates to zebrafish models for neurodegenerative disorders that allow screening of compounds for their ability to protect and/or regenerate neurons in vivo in a whole vertebrate organism. The present invention also provides methods of identifying gene targets for neuroprotective compounds, compounds that regenerate neurons and compounds that... Agent: Patent Correspondence Arnall Golden Gregory LLP

20090181403 - Ceacam1 based point-of-care cancer diagnostic: The present technology regards the utilization of CEACAM1 as a biomarker for cancer. In particular the present invention regards the detection and measurement of soluble CEACAM1 levels for the detection and diagnosis of melanoma.... Agent: Mcandrews Held & Malloy, Ltd

20090181404 - Cell-based fluorescent assays for identifying alpha and delta enac modulators: This invention relates to improved electrophysiological assays that measure sodium conductance activity of a delta or alpha human epithelial sodium channel (ENaC) expressed in a test cell in the presence and absence of delta hENaC enhancers. The improvement comprises contacting the test cells with an amount of sodium ion, typically... Agent: Hunton & Williams LLP Intellectual Property Department

20090181402 - Compositions and methods for coupling a plurality of compounds to a scaffold: Compositions and methods are provided for coupling a plurality of compounds to a scaffold. Compositions and methods are further provided for catalyzing a reaction between at least one terminal alkyne moiety and at least one azide moiety, wherein one moiety is attached to the compound and the other moiety is... Agent: Talivaldis Cepuritis Olson & Cepuritis, Ltd.

20090181406 - Kits for detecting cervical dysplasia: This invention provides methods and kits for improved diagnosis of medically relevant conditions by solution based biochemical testing procedures performed in solutions of test samples. The invention provides a method to substitute the cell based morphological information contained within the cytological and/or histological data of the test sample by molecular... Agent: Howrey LLP-ca

20090181405 - Methods for treating cardiac disease by modifying an n-terminal domain of troponin 1: The invention provides methods for identifying modulators of cardiac troponin I activity as well as methods for using N-terminally truncated forms of cTnI to monitor the function of the circulatory system in general, and the heart in particular, of an organism such as man. Additionally, the invention provides methods of... Agent: Marshall, Gerstein & Borun LLP

20090181410 - Immunoglobulin peptides against asian pangasius catfish: The present invention relates in part to antibodies for the performance of immunoassays to determine whether a test sample, such as a food sample, contains tissue derived from a Pangasius species of fish, such as tra or basa. Such antibodies, either alone or in combination, specifically bind to a thermostable... Agent: Jagtiani + Guttag

20090181409 - Optical biosensor method for cell-cell interaction: An apparatus and non-invasive method to measure cell-cell interactions, such as T-cell and stem cell interactions, under physiologically relevant conditions, and optionally measure the effects of stimuli on the cell-cell interactions, as defined herein.... Agent: Corning Incorporated

20090181407 - Method and kit for detecting the early onset of renal tubular cell injury: A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell injury. NGAL protein expression is detected predominantly in... Agent: Hasse & Nesbitt LLC

20090181408 - Flavin adenine dinucleotide-binding glucose dehydrogenase: The object is to provide a novel enzyme which enables to determine the glucose level more accurately, a bacterium capable of producing the enzyme, and use of the enzyme. Disclosed is a flavin adenine dinucleotide-binding glucose dehydrogenase having the following properties (1) to (3): (1) the enzyme has an activity... Agent: Edwards Angell Palmer & Dodge LLP

20090181411 - Methods and devices for microfluidic point-of-care immunoassays: Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.... Agent: Seed Intellectual Property Law Group PLLC

20090181412 - Method of storing analytical reagent into microfluidic device: Provided is a method of storing a reagent in a microfluidic device. The reagent, in a liquid form, is loaded into reaction chambers arranged on the microfluidic device; followed by lyophilization as being contained in the microfluidic device.... Agent: Sughrue Mion, PLLC

20090181413 - Simultaneous and differential quantification of two target analytes in biological sample: This invention provides a method for differentially and simultaneously quantifying two target analytes via a single assay operation with the use of a single type of reagent in each of the two steps, i.e., the first step and the second step. In this method, the reaction product associated with the... Agent: Foley And Lardner LLP Suite 500

20090181415 - Prediction of genotoxicity: The likelihood that a compound will exhibit genotoxicity in a micronucleus test is predicted by the ability of the compound to inhibit a plurality of kinases from a selected group.... Agent: Roche Palo Alto LLC Patent Law Dept. M/s A2-250

20090181414 - Retentate chromatography and protein chip arrays with applications in biology and medicine: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical... Agent: Townsend And Townsend And Crew LLP

20090181416 - Enzyme detection technique: A diagnostic test kit for detecting the presence or absence of an enzyme (e.g., leukocyte esterase) within a test sample is provided. The test kit comprises a substrate that is capable of being cleaved in the presence of the enzyme to release a nucleophilic aromatic compound. The kit also comprises... Agent: Dority & Manning, P.A.

20090181417 - Colorimetric measurement of enzymatic activity in cell lysates: The present invention concerns a method for the calorimetric measurement of enzyme activity comprising the following steps: preparing a cell suspension or a cell lysate containing cell components, adding a chromogenic substrate at the start of the enzyme reaction, adding a first additional substance to stop the enzyme reaction, and... Agent: Roche Diagnostics Operations Inc.

20090181420 - Inhibiting smad signaling promotes neuron regeneration: Regeneration of a lesioned CNS axon of a mature neuron, determined to be subject to regeneration inhibition by Smad2/3 signaling, is promoted by contacting the neuron with an inhibitor of Smad2/3 signaling sufficient to promote regeneration of the axon.... Agent: Richard Aron Osman

20090181419 - Method for quantitatively determining the apolipoprotein ai content in the hdl 2b subfraction of hdl cholesterol subfractions: The invention provides a method (e.g., a computer algorithm) for calculating a number of particles in a HDL subfraction. The method features the steps of: 1) measuring an initial distribution of HDL particles (e.g., a relative mass distribution) from a blood sample; 2) processing the initial distribution of HDL particles... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090181418 - Peptide able to break the m-p53/p63, m-p53/p73 and m-p53/respective isoform proteins complex formed in the tumor cells and uses thereof in the pharmacological field: The object of the present invention is the identification of a group of peptides able to break the interaction between the mutated protein p53 (hereinafter m-p53) and the proteins p63, p73 and the relative isoform proteins (hereinafter p63, p73 and p-isoforms) in the m-p53/p63, m-p53/p73 and m-p53/p-isoforms proteinic complex that... Agent: Pearne & Gordon LLP

20090181421 - Diagnosis of fetal abnormalities using nucleated red blood cells: The present invention relates to methods for diagnosing a condition in a fetus by enriching and enumerating circulating red blood cells with the possible combination of results from maternal serum marker screens.... Agent: Proskauer Rose LLP

20090181422 - Method and apparatus for producing histological sections with a microtome: A method and apparatus for producing histological sections by means of a microtome are suggested. A histological section of predefined thickness is produced with a microtome from a block comprising a tissue sample. A carrier material is applied with an application apparatus onto the block prior to before production of... Agent: Alexander R Schlee SchleeIPInternational P.C.

20090181423 - Substantially animal protein-free recombinant furin and methods for producing same: The present invention relates to recombinant furin (rFurin) and methods for producing rFurin. More specifically, the invention relates to substantially animal protein-free rFurin and methods for producing substantially animal protein-free rFurin.... Agent: Baxter Healthcare Corporation

20090181426 - Cell culture methods for producing recombinant proteins in the presence of reduced levels of one or more contaminants: The invention relates to cell culture methods, kits and cell lines for producing recombinant products, e.g. therapeutic proteins and antibodies, in the presence of reduced levels of one or more contaminants and further to methods of purifying those products.... Agent: Millipore Corporation

20090181427 - Hybrid 3' untranslated regions suitable for efficient protein expression in mammalian cells: The present invention describes the use of hybrid short 3′ untranslated (3′UTR) regions which are composed of two regions, one region from an 3′ untranslated region of a stable eukaryotic mRNA, and another region from the downstream end of an 3′ untranslated region of another eukaryotic mRNA that contains a... Agent: Scully Scott Murphy & Presser, PC

20090181425 - Library of translational fusion partners for producing recombinant proteins and translational fusion partners screened therefrom: The invention relates to techniques for the rapid screening of suitable translational fusion partners (TFPs) capable of inducing secretory production of recombinant proteins, especially proteins that are difficult to produce using conventional recombinant production methods.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090181424 - Mammalian expression vector comprising the mcmv promoter and first intron of hcmv major immediate early gene: A mammalian expression vector that is a murine CMV promoter and the first intron of the major immediate early gene of the human cytomegalovirus. There are mammalian host cells containing the expression vector. There is also a process for the production of recombinant protein by using the expression vector.... Agent: Fisher, Christen & Sabol

20090181428 - Method for producing target proteins using amino acids and pyruvic acids in culture of plant cells: Provided is a method for producing a target protein via cultivation of transgenic plant cells comprising a promoter capable of expressing the protein under sugar-free conditions or in response to the depletion of sugar and a gene encoding the target protein, without exchange of a cell growth medium with a... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090181429 - Systems for the expression of orthogonal translation components eubacterial host cells: The invention relates to compositions and methods for the in vivo production of polypeptides comprising one or more unnatural amino acids. Specifically, the invention provides plasmid systems for the efficient eubacterial expression of polypeptides comprising one or more unnatural amino acids at genetically-programmed positions.... Agent: Quine Intellectual Property Law Group, P.C.

20090181430 - Protein folding: The present invention concerns a method for folding a Transforming Growth Factor Beta, or a functional analogue thereof, into a dimeric, biologically active form. The method involves adding solubilized, unfolded monomeric growth factor to a solution containing 2-(cyclohexylamino)-ethanesulfonic acid (CHES) or a functional analogue thereof and a low molecular weight... Agent: Goodwin Procter LLP Patent Administrator

20090181431 - Fusion proteins between plant cell-wall degrading enzymes, and their uses: The invention relates to the use of fusion proteins between at least two plant cell-wall degrading enzymes, the enzymes being such that they do not contain a C-terminal carbohydrate-binding-molecule (CBM), and optionally a CBM, the enzymes and CBM being recombinant proteins corresponding to native proteins in fungi, or mutated forms... Agent: Young & Thompson

20090181432 - Process for self-assembly of structures in a liquid: A process and apparatus for DNA sequencing is provided. In the field of DNA analysis, an iterative process is disclosed wherein an apparatus with a set of recognition chambers in which a species of recognition element nucleotides are differentially added and subjected to a polymerization reaction allows recognition of which... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20090181433 - Methods for producing end-products from carbon substrates: The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction... Agent: Genencor International, Inc. Attention: Legal Department

20090181434 - Transgenic photosynthetic microorganisms and photobioreactor: Provided herein is a transgenic bacteria engineered to accumulate carbohydrates, for example disaccharides. Also provided is a photobioreactor for cultivating photosynthetic microorganisms comprising a non-gelatinous, solid cultivation support suitable for providing nutrients and moisture to photosynthetic microorganisms and a physical barrier covering at least a portion of the surface of... Agent: Sonnenschein Nath & Rosenthal LLP

20090181435 - Method for determining l-serine, gene sequene, vectors and micro-organisms: The folic acid concentration in amino acid producing organisms is reduced or completely removed in order to increase the production of L-serine. The enzymes and genes, which are involved in the biosynthesis of folic acid, can be completely excluded or at least reduced in activity. In a preferred embodiment, SEQ... Agent: Jordan And Hamburg LLP

20090181436 - Concentration and separation of lipids from renewable resources: Disclosed are methods that can advantageously utilize the natural consumptive and conversion processes of an aquatic organism culture system to concentrate and separate microbial plant-generated lipids. For instance, an aquatic organism culture can be maintained and/or grown upon an algal biomass. The natural conversion processes of the animals allows for... Agent: Dority & Manning, P.A.

20090181437 - Method for producing a conjugated linoleic acid glyceride: A method for producing a conjugated linoleic acid glyceride in the form of an ester bond of a conjugated linoleic acid with glycerol, involving reacting a starting material containing a linoleic acid glyceride with a microorganism or an enzyme generated by the microorganism which has a potency to isomerize the... Agent: Frishauf, Holtz, Goodman & Chick, PC

20090181438 - Optimization of biofuel production: Embodiments of the present invention includes an apparatuses, compositions, and methods utilizing mechanical and chemical engineering strategies to achieve even greater efficiencies in biofuels production from oleaginous organisms. These increased efficiencies may be achieved through the application of targeted and well-designed chemical and mechanical engineering methods disclosed herein to achieve... Agent: Standley Law Group LLP

20090181439 - Process for enzymatically preparing carboxylic esters: Process for enzymatically synthesizing carboxylic esters, characterized in that mixing and discharge of the water of reaction are effected by introducing a gas while achieving low effectiveness ratios EV.... Agent: Frommer Lawrence & Haug

20090181440 - Systems and processes for cellulosic ethanol production: A cellulosic ethanol production system. Implementations may include a feed stage that may produce a raw cellulose stream from a waste cellulose stream and an algae cellulose stream. A hydrolysis stage may produce a hydrolyzed cellulose stream. A liquefaction stage may produce a formed sugars stream and one or more... Agent: Booth Udall, PLC

20090181442 - Method of chemically modifying polymer surfaces intended for immobilizing molecules: The method comprises chemical modification of an optionally metallized polymer surface, for example a polycarbonate surface or a polymethacryllate surface functionalized with amino groups, said surfaces being optionally metallized, by treating said polymer surface with a mercaptoalkanoic acid or the salts or derivates thereof. The surfaces obtained by said method... Agent: Klauber & Jackson

20090181441 - Porous silicon-polymer composites for biosensor applications: The disclosure relates to porous silicon/conductive polymer composites that can be used in biosensor applications (e.g., in a binding assay that captures a target analyte). The composite material generally includes (a) a p-doped silicon substrate that has a porous surface; (b) a lawn of a conductive polymer bound to the... Agent: Ian C. Mcleod Ian C. Mcleod, P.C.

20090181443 - Identification, cloning, expression, and a purification of three novel human calcium-independent phospholipase a2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities: Isolated novel and purified and characterized phospholipase A2, referred to herein as calcium-independent phospholipase A2zeta (iPLA2zeta) having SEQ. ID. NO: 2 (See FIG. 1), and nucleic acid sequence (SEQ. ID. NO: 4), and calcium-independent phospholipase A2eta (iPLA2eta) having SEQ. ID. NO: 3 (See FIG. 1), and nucleic acid sequences (SEQ.... Agent: Patrick W. Rasche (15060) Armstrong Teasdale, LLP

20090181444 - Modified carbohydrate processing enzyme: A modified polypeptide having carbohydrate processing enzymatic activity is provided, said polypeptide comprising an amino acid sequence selected from: (a) the amino acid sequence of SEQ ID NO:2 comprising a mutation in at least one of W433, E432 and M439; (b) the amino acid sequence of an enzyme of glycosyl... Agent: Nixon & Vanderhye, PC

20090181445 - Crystallization and structure of a plant peptide deformylase: This invention relates to the crystal structure of a plant peptide deformylase polypeptide and methods of using the structure to design compounds that modulate the activity of the polypeptide.... Agent: Crowell & Moring LLP Intellectual Property Group

20090181446 - Method for propagating influenza virus: A method for producing influenza virus on large scale is provided. A method for propagating influenza virus which comprises, after removing or decreasing a trypsin inhibitor secreted into culture of MDCK cells (cell line derived from dog kidney) by washing with a culture medium or a buffer, inoculating influenza virus... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090181447 - Grass endophytes: The present invention relates to a combination of a Neotyphodium species endophyte or endophyte culture in a symbiotic association with a host grass which association does not cause symptoms of toxicosis in animals through exclusion of ergovaline but, due to the inclusion of alkaloids including agroclavine, setoclavine or isosetoclavine, retains... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090181448 - Perfusion type vascular tissue bioreactor with rotary and stretching functions: The present invention in one aspect provides a bioreactor for vascular construct that comprises a pulse-generating device with simple structure and reliable and stable pulse-generating operation. In another aspect, the present invention provides bioreactor for vascular construct that implements rotation of vascular construct and culture chamber, axial stretching of vascular... Agent: Lanier Ford Shaver & Payne P.C.

20090181449 - Device and method for automating microbiology processes: A device and method for automating the handling and testing of microbiological specimens are provided. A portable specimen collection vehicle (SCV) is provided which comprises a protective housing, a specimen chamber for receiving a biospecimen sample, a plurality of culturing chambers each for receiving a portion of the biospecimen sample... Agent: Leydig Voit & Mayer, Ltd

20090181450 - Metod and unit for preparing a sample for the microbiological analysis of a liquid: The preparation unit comprises a body (2) within which are fixed a first (3) and a second (4) membrane, said first membrane (3) having a first predetermined pore diameter and said second membrane (4) a second predetermined pore diameter smaller than said first predetermined pore diameter of said first membrane... Agent: Nields, Lemack & Frame, LLC

20090181451 - Specimen sample collection device and test system: A specimen sample collection device and test system includes a handle having a sufficiency indicator, an absorbent pad partially contained within said handle, a pad compression tube insertable over said absorbent pad within said handle and around an end of said handle, and a collection tube having one or more... Agent: Rylander & Associates PC

20090181452 - Cell culture and mixing vessel: A mixing vessel (10) for containing a liquid, comprises a chamber having a lower chamber portion and an upper chamber portion wider than the lower portion, gas inlet means (14) for supplying gas to the lower portion and means for redirecting rising gas (24), such that, in use, rising gas... Agent: Morgan Lewis & Bockius LLP

20090181453 - Mesoderm and definitive endoderm cell populations: The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.... Agent: Crowell & Moring LLP Intellectual Property Group

20090181454 - Photoreactive regulator of glutamate receptor function and methods of use thereof: The present invention provides a synthetic regulator of glutamate receptor function, which regulator is a light-sensitive (photoreactive) regulator. The present invention further provides a light-regulated glutamate receptor that includes a subject synthetic regulator non-covalently associated with the glutamate receptor. Also provided are cells and membranes comprising a subject light-regulated glutamate... Agent: Uc Berkeley - Otl Bozicevic, Field & Francis LLP

20090181456 - Adipose-derived stem cells and lattices: The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells.... Agent: Mandel & Adriano

20090181455 - Modulation of gene expression using insulator binding proteins: Methods and compositions for regulating gene expression are provided. In particular, methods and compositions including insulator domains for targeted regulation of a gene or transgene are provided.... Agent: Robins & Pasternak

20090181457 - Apparatus and method for isolating histological sections produced with a microtome: An apparatus and a method for isolating histological sections produced with a microtome and a microtome are suggested. A previously and currently produced histological section are connected to form a section strip. In order to simplify isolating the previously and currently produced histological sections from each other a nozzle device... Agent: Alexander R Schlee SchleeIPInternational P.C.

20090181459 - Mouse glucocorticoid-induced tnf receptor ligand is costimulatory for t cells: The present invention provides mGITRL proteins, nucleotide molecules encoding same, mGITRL messenger RNA molecules, methods of expressing a recombinant gene in an immune cell and of stimulating CD4+CD25− T cells, comprising same or comprising agonist anti-GITR antibodies.... Agent: Pearl Cohen Zedek Latzer, LLP

20090181458 - Tubulo-vesicular structure localization signals: The invention relates to polarized cell tubulo-vesicular structure localization signals. The localization signals are utilized as research tools or are linked to polypeptides of interest or therapeutic molecules. Disclosed are methods of making and using polypeptides and modified polypeptides as signals to localize therapeutics, experimental compounds, peptides, proteins and/or other... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090181460 - Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants: This invention comprises a combined transgene/virus vector system for the expression of heterologous proteins in plants. While exemplified with respect to the bipartite RNA plant virus, Cowpect mosaic virus (CPMV), other bipartite viral systems may be used to advantage according to the method, system and composition described in detail herein.... Agent: Dann, Dorfman, Herrell & Skillman

  
07/09/2009 > patent applications in patent subcategories. category listing

20090176199 - Method of isotope labeling and determining protein synthesis, quantitation and protein expression: A method including isotope labeling of a newly synthesized protein in a sufficient quantity such that a newly synthesized protein spectra and the pre-existing protein spectra are sufficiently separated. A further method including determining a ratio of a new and a pre-existing protein from mass spectra obtained by using mass... Agent: Blakely Sokoloff Taylor & Zafman LLP

20090176204 - Method for improved diagnosis of dysplasias: The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without... Agent: Howrey LLP-ca

20090176202 - Methods of detecting inhibitors of vif-mediated apobec3g degradation and hiv: The invention comprises methods and cell lines for assaying APOBEC3G degradation and methods for identifying inhibitors of APOBEC3G degradation. The invention also provides methods of identifying inhibitors of HIV infection. The methods of the invention are useful for identifying inhibitors of viral infection, in particular, the methods of the invention... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090176201 - Microbubbles for affinity separation: The present invention relates to methods, compositions and kits for affinity isolation, affinity purification and affinity assay based on microbubbles coated with an affinity molecule. Particularly, the invention provides protein microbubbles coated with an affinity molecule. In addition, the invention provides glass microbubbles coated with an affinity molecule. Methods of... Agent: Duane Morris LLP - San Diego

20090176200 - Modified human hepatitis c virus genomic rna that can be autonomously replicated: The present invention provides modified hepatitis C virus genomic RNA, comprising nucleotide sequences of genomic RNA portions of two or more types of hepatitis C viruses, which comprises a 5′ untranslated region, a core protein coding sequence, an E1 protein coding sequence, a p7 protein coding sequence, an E2 protein... Agent: Birch Stewart Kolasch & Birch

20090176203 - Mutant hsv, materials and methods for generation of mutant hsv: A method of generating a mutant Herpes Simplex Virus (HSV) is disclosed, wherein the generated HSV genome comprises nucleic acid encoding a nucleic acid sequence of interest, the method comprising the steps of: i. providing a nucleic acid vector comprising nucleic acid encoding first and second site specific recombination sequences... Agent: Swanson & Bratschun, L.L.C.

20090176216 - Alleles and polymorphisms predictive of responsiveness to biologic therapy in psoriasis: The invention provides methods for predicting responsiveness to a biologic agent in a subject suffering from psoriasis. The methods involve assaying for the presence or absence of an allele or polymorphism in the subject that is predictive of responsiveness to biologic therapy, such as an HLA-Cw6 allele, a TNFα 238... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090176220 - Antibody characterization test: The present invention relates to a method for measuring the ability of an antibody preparation to activate an Fc receptor, wherein this method comprises the following steps: a) aggregating said antibodies with one another, b) bringing cells expressing an Fc receptor into contact with said aggregated antibodies, and c) measuring... Agent: Marsh, Fischmann & Breyfogle LLP

20090176232 - Assessment of reaction kinetics compatibility between polymerase chain reactions: A method compares amplification reaction kinetics between two or more quantitative polymerase chain reactions (PCR). These methods enable quality control and/or quality assessment for quantification of nucleic acids by PCR. The method estimates plurality of parameters from each reaction and compares them simultaneously between reactions.... Agent: Merchant & Gould PC

20090176236 - Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup: The present invention provides rapid and accurate methods, primers, probes and kits for identifying the presence of a certain flaviviruses in a sample. Flaviviruses that can be detected include members of the Japanese encephalitis virus serogroup, Dengue virus, St. Louis encephalitis virus, Montana myotis leukoencephalitis virus, Modoc virus, and Yellow... Agent: Townsend And Townsend And Crew, LLP

20090176241 - Compositions and methods for detecting group b streptococci: Compositions, methods and kits for detecting Group B streptococci. Particularly described are oligonucleotides that are useful as amplification primers and hybridization probes for detecting very low levels of Group B streptococci nucleic acids.... Agent: Gen Probe Incorporated

20090176242 - Compositions and methods for labeling of nucleic acid molecules: The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic... Agent: Invitrogen Corporation C/o Intellevate

20090176223 - Compositions, kits, and methods for the diagnosis, prognosis, and monitoring of immune disorders using galectin-1: The present invention is based, in part, on the discovery that galectin-1 (Gal1) plays a role in immune disorders, including Hodgkin lymphoma, anaplastic large cell lymphoma, or MLL+ pre B-cell ALL. Accordingly, the invention relates to compositions, kits, and methods for diagnosing, prognosing, and monitoring immune disorders, e.g., Hodgkin lymphoma,... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20090176238 - Cynomolgus toll-like receptor 3: Isolated polynucleotides encoding Cynomolgus monkey Toll-Like Receptor 3 (cynoTLR3), polypeptides obtainable from expression of these polynucleotides, recombinant cells, methods and uses of these are disclosed.... Agent: Philip S. Johnson Johnson & Johnson

20090176225 - Diagnostic test for collie eye anomaly: The invention relates to a method for identifying dogs which are genetically normal, heterozygous for, or homozygous for the mutation primarily responsible for Collie eye anomaly (CEA). The method comprises the steps of obtaining a biological sample from a dog and testing DNA in the biological sample for the presence... Agent: Hodgson Russ LLP The Guaranty Building

20090176219 - Dna binding site of a transcriptional activator useful in gene expression: We have discovered DNA binding sites which are specifically recognized by PrtT, a transcriptional activator for protease genes. The DNA binding site can be defined structurally by a consensus nucleotide sequence and functionally by PrtT's ability to regulate transcriptional activation through that sequence. Both PrtT and its cognate DNA binding... Agent: Nixon & Vanderhye, PC

20090176234 - Efficient base determination in sequencing reactions: The present invention is directed to compositions and methods for nucleic acid identification and detection. Compositions and methods of the present invention include extracting and fragmenting target nucleic acids from a sample, using the fragmented target nucleic acids to produce target nucleic acid templates and subjecting those target nucleic acid... Agent: Morgan, Lewis & Bockius, LLP

20090176211 - Fluorescent protein: It is an object of the present invention to provide a fluorescent protein, which allows an acceptor for fluorescence resonance energy transfer (FRET) to appear in a stimulating light-dependent manner, thereby enabling the marking of any given cell organelle, cells, or tissues, with multiple colors. The present invention provides a... Agent: Greenblum & Bernstein, P.L.C

20090176222 - Gene for identifying individuals with familial dysautonomia: This invention relates to methods and compositions useful for detecting mutations which cause Familial Dysautonomia. Familial dysautonomia (FD; Riley-Day syndrome), an Ashkenazi Jewish disorder, is the best known and most frequent of a group of congenital sensory neuropathies and is characterized by widespread sensory and variable autonomic dysfunction. Previously, we... Agent: King & Spalding

20090176215 - Gene methylation in prostate cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with prostate cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of prostate cancer.... Agent: Townsend And Townsend And Crew, LLP

20090176235 - Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods... Agent: Celera

20090176228 - Lung cancer markers, and uses thereof: Methods and compositions are provided for assessing (e.g., diagnosing), treating, and preventing diseases, especially cancer, and particular lung cancer, using lung cancer markers (LCM). Individual LCM and panels comprising multiple LCM are provided for these and other uses. Methods and compositions are also provided for determining or predicting the effectiveness... Agent: Celera Corporation

20090176226 - Method for diagnosing autism spectrum disorder: The present invention provides methods of diagnosing and/or predicting autism spectrum disorder comprising determining the presence of microdeletions and microduplications on chromosomes 15 and 16.... Agent: David S. Resnick

20090176212 - Method for fixing a supercoiled dna and the use for analyzing the dna repair: A method for fixing a supercoiled DNA consists in deposing a supercoiled DNA sample on the surface of a porous polymer film, in fixing said supercoiled DNA therein by a passive diffusion, in obtaining a support by the inventive method and in using said support for analysing the DNA distribution.... Agent: The Nath Law Group

20090176227 - Method for producing polyploid plants of orchids: A method for producing polyploid plants of orchids includes the steps of: providing a protocorm or protocom-like body (PLB) of an orchid, the protocorm or PLB having an upper portion with a growing point and a lower portion without any growing point; cutting the protocorm or PLB approximately at a... Agent: Kamrath & Associates P.A.

20090176218 - Method for the diagnosis and prognosis of cancer: Disclosed are methods for prognostic evaluation, and diagnosis of cancers. The methods of the present invention allow for the diagnosis and prognosis of cancers by analyzing the levels of expression of an enzyme that is involved in the biosynthetic pathway of spermine within tissue samples containing cancerous tissues. In particular,... Agent: David S. Resnick

20090176221 - Method of detecting an analyte in a sample using semiconductor nanocrystals as detectable label: The use of semiconductor nanocrystals as detectable labels in various chemical and biological applications is disclosed. The methods find use for detecting a single analyte, as well as multiple analytes by using more than one semiconductor nanocrystal as a detectable label, each of which emits at a distinct wavelength.... Agent: Invitrogen Corporation C/o Intellevate

20090176229 - Methods and compositions for the identification of insect repellent compounds: Methods for identifying a candidate compound with an ability to modulate cation transport through a transient receptor potential (TRP) channel in a cell are disclosed. The methods can include (a) providing a cell expressing a recombinant nucleic acid sequence encoding an transient receptor potential (TRP) channel gene product or a... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20090176208 - Methods for detecting, identifying and reporting the presence of animal pathological agents: A business method for use in detecting the presence of one or more pathological agents in a biological sample taken from an animal, using known diagnostic methods including antibodies and PCR, marketing test kits for obtaining and transporting biological samples from animals to a processing center, and reporting the results... Agent: Mandel & Adriano

20090176207 - Methods for determining risk of developing regular smoking behavior: The present invention relates in general to human genetic polymorphisms and their association with human health and to methods and materials for analyzing allelic variations, and to the use of genetic polymorphisms in the diagnosis and treatment of smoking behavior and nicotine dependence. Provided herein are methods for determining risk... Agent: Washington University-snr C/o Sonnenschein Nath & Rosenthal L.l.p

20090176210 - Microbial reductive dehalogenation of vinyl chloride: Compositions and methods are provided that relate to the bioremediation of chlorinated ethenes, particularly the bioremediation of vinyl chloride by Dehalococcoides-like organisms. An isolated strain of bacteria, Dehalococcoides sp. strain VS, that metabolizes vinyl chloride is provided; the genetic sequence of the enzyme responsible for vinyl chloride dehalogenation; methods of... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090176230 - Microfluidic device and methods of using same: A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited... Agent: Townsend And Townsend And Crew, LLP

20090176240 - Mn/ca ix and cancer prognosis: Herein disclosed are methods that are prognostic for neoplastic/preneoplastic disease in a subject vertebrate, wherein said disease is associated with a tissue that normally expresses MN, but which MN expression is lost or diminished upon carcinogenesis. Exemplary of the types of preneoplastic/neoplastic diseases subject to the prognostic methods of this... Agent: Leona L. Lauder Attorney At Law

20090176205 - Mutant proteins in the dna-binding domain of a telomeric protein, trf2, and telomeric dna mutants, and use of the complex structure of the trf2 dna-binding domain and telomeric dna: r

20090176217 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis: Novel splice variants, amino acid sequences and nucleotide sequences thereof, and methods of using same.... Agent: Fennemore Craig

20090176231 - Probe for detecting abl gene mutation and uses thereof: Detection probes are provided that are capable of detecting a sequence to be detected containing a mutation even when a sequence not to be detected containing no mutation coexists with the sequence to be detected containing a mutation, which are different only in a single base from each other. At... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090176214 - Recombinant antigens for the detection of coxiella burnetii: The invention relates to a method for the detection of prior exposure to Coxiella. burnetii infection by antibody-based assays using recombinant, immunodominant C. burnetii polypeptides. The invention also relates to the design of biotin or His-tagged C. burnetii proteins useful in the antibody-based assays as standardized antigen reagents.... Agent: Naval Medical Research Center Attn: (code 00l)

20090176233 - Screening assays for polymerase enhancement: Methods of screening for and selecting for improved polymerases suitable for single molecule sequencing are provided.... Agent: Quine Intellectual Property Law Group, P.C.

20090176209 - Selection: The present invention to a nucleotide sequence encoding one or more Arc DNA binding domains, one or more Arc DNA binding sites and at least one polypeptide domain.... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20090176239 - Single-molecule-format real-time bioluminescence imaging probe: The present invention is characterized by using, as a single-molecule-format luminescent probe utilizing the increase and decrease of a second messenger level as an index, a fusion protein including a single-chain protein containing a second messenger recognition protein and optionally a peptide which is capable of binding with the protein,... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20090176213 - Stabilization of solid support assay reagents: Reagents are disclosed for use in assays for analytes. The reagents are dry assay reagents that may be readily reconstituted for use in the assays. The dry assay reagents comprise a solid support and one or more molecules of a receptor immobilized on the solid support. The receptor comprises one... Agent: Dade Behring Inc. Law And Patents

20090176206 - Toll-like receptor 2 (tlr-2) haplotypes predict outcome of patients: The invention provides methods and kits for obtaining a prognosis for a subject having or at risk of developing an inflammatory condition and or a gram positive infection. The method generally includes determining a toll-like receptor 2 (TLR-2) risk genotype of a subject for one or more SNPs, comparing the... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090176224 - Udder health characteristics: The invention relates to a method for determining udder health characteristics in bovine subjects, wherein udder health characteristics comprise sub-clinical and clinical mastitis. In particular, the method of the invention involves identification of genetic markers and/or Quantitative Trait Locus (QTL) for the determination of udder health characteristics in a bovine... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20090176237 - Use of micro-rna as a biomarker of immunomodulatory drug activity: Methods of determining the activity of an immunomodulatory compound by measuring the presence of an miRNA in a sample are disclosed. Additionally disclosed are methods of assessing the patient compliance in patients treated with an immunomodulatory compound.... Agent: Jones Day

20090176246 - Assay for measuring factor viia-antithrombin complexes: A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing patient risk for hypercoagulation or other coagulopathies, and monitoring patients for factor VIIa-antithrombin complexes over time which can reveal changes in risk for hypercoagulation... Agent: Eugenia S. Hansen Hemingway & Hansen, LLP

20090176247 - Determination of sflt-1:angiogenic factor complex: Methods for determining the presence or amount of a complex comprising a first and second molecular entity are provided, preferably an sFlt-1:PlGF complex. A determination of the presence or amount of the complex can be used in methods for predicting, detecting, monitoring a disease, or guiding therapy in respect to... Agent: Philip S. Johnson Johnson & Johnson

20090176249 - Method for detecting cardiac collateral formation: The present invention relates to a method of detecting collateral artery formation by measuring the level of NT-pro-BNP or BNP in an individual.... Agent: Licata & Tyrrell P.C.

20090176248 - Method for evaluating kidney function in a feline: Methods for (1) evaluating feline kidney function by determining ghrelin level in feline tissue or biofluid and correlating the ghrelin level directly to kidney function and (2) diagnosing kidney disease in a feline comprises determining an observed ghrelin level in a tissue or biofluid of the feline and comparing the... Agent: Colgate-palmolive Company

20090176244 - Methods and compositions for the diagnosis of crohn's disease: The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain embodiments, the need for more laborious and/or... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090176243 - Novel monkey gpr103 and monkey qrfp and method of evaluating compound by using gpr103: There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for functional analysis of the GPR103 genes and proteins and for the compound evaluation. The nucleic acids or proteins having the... Agent: Merck And Co., Inc

20090176245 - Rheumatoid arthritis test method and treating method: It is intended to evaluate the prognosis of rheumatoid arthritis based on the evaluation of the disease severity of the patient to select a treatment method suitable for each rheumatoid arthritis patients, and to measure HSC71 protein levels of the patients before and after the administrations of therapeutic agents to... Agent: Kilyk & Bowersox, P.l.l.c.

20090176250 - Immunoliposome-nucleic acid amplification (ilnaa) assay: Immunoliposomes and use thereof in highly specific and sensitive nucleic acid amplification assays relying on amplification of specific nucleic acid sequences released from encapsulation within a liposome after a receptor on the liposome couples with a targeted analyte/antigen immobilized on a select surface. The immunoliposome nucleic acid amplification assay permits... Agent: Office Of The Staff Judge Advocate U.s. Army Medical Research And Materiel Command

20090176254 - Mammalian galanin receptors: The present invention provides isolated mammalian GalR3 receptors, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the receptors using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20090176255 - Immunomagnetic capture and imaging of biological targets: The present invention relates to methods and systems for labeling, isolating, detecting, and/or enumerating a statistically significant number of biological cells, or other biological analytes of interest, present in a complex matrix sample. The isolation of a biological target of interest from a sample mixture is done by immunomagnetic separation.... Agent: Fulbright & Jaworski L.L.P.

20090176253 - Antibody conjugates: Antibody/signal-generating moiety conjugates are disclosed that include an antibody covalently linked to a signal-generating moiety through a heterobifunctional polyalkyleneglycol linker. The disclosed conjugates show exceptional signal-generation in immunohistochemical and in situ hybridization assays on tissue sections and cytology samples. In one embodiment, enzyme-metallographic detection of nucleic acid sequences with hapten-labeled... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20090176252 - Method for the measurement of endocrine substances in an analyte: The method for the measurement of the endocrine substance in the analyte according to the present invention comprises pre-treating the analyte derived from the animal such as feline or the like by removing an autoantibody bound to the endocrine substance present in the analyte therefrom and measuring the endocrine substance... Agent: Birch Stewart Kolasch & Birch

20090176251 - Methods for diagnosing celiac disease based on the level of anti-gliadin and anti-ttg iga and igg antibodies: The present invention is in the field of diagnosing celiac disease. More particularly, the present invention relates to a method to diagnose celiac disease based on the level of anti-gliadin and anti-tissue transglutaminase antibodies.... Agent: The Nath Law Group

20090176257 - Methods and biomarkers for diagnosing and monitoring psychotic disorders: The invention relates to methods of diagnosing or monitoring a psychotic disorder in a subject comprising providing a test biological sample from the subject, performing spectral analysis on said test biological sample to provide one or more spectra, and, comparing the one or more spectra with one or more control... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090176256 - Methods and products for evaluating an immune response to a therapeutic protein: The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. A first aspect of the invention relates to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4... Agent: Wolf Greenfield & Sacks, P.C.

20090176258 - Test for the detection of pathological prions: The am of the invention is to create a method for detecting pathological prions which is highly sensitive, can be carried out quickly and at a low cost, and allows prions to be detected at an early stage of a disease. Said aim is achieved by the fact that immobilized... Agent: Marshall, Gerstein & Borun LLP

20090176259 - Methods for detection of botulinum neurotoxin: Provided herein is a large immuno-sorbent surface area assay (ALISSA) for rapid and sensitive detection of toxin or enzyme activity. This assay is designed to capture a low number of toxin or enzyme molecules and to measure their intrinsic protease activity via conversion of a fluorigenic or luminescent substrate. The... Agent: Perkins Coie LLP

20090176260 - Double-fusion human embryonic stem cells, methods of making double-fusion human embryonic stem cells, triple-fusion human embryonic stem cells, methods of making triple-fusion human embryonic stem cells, and methods of monitoring double-fusion human embry: Embodiments of the present disclosure include double-fusion human embryonic stem cells, methods of imaging double-fusion human embryonic stem cells, double-fusion polynucleotides, double-fusion proteins, triple-fusion human embryonic stem cells, methods of imaging triple-fusion human embryonic stem cells, triple-fusion polynucleotides, triple-fusion proteins, methods of monitoring the progression of human embryonic stem cells,... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20090176261 - Method of determining the point at which coagulating blood forms a clot: The present invention is concerned with a method and apparatus for determining the instant at which coagulating blood forms a clot—the primary function of a clot being to act as a hemostatic plug at the site of a lesion in the circulatory system. The method comprises applying a harmonically time-varying... Agent: Waddey & Patterson, P.C.

20090176262 - Coenzyme-binding glucose dehydrogenase: The present invention provides a microorganism-derived soluble coenzyme-binding glucose dehydrogenase which catalyzes a reaction for oxidizing glucose in the presence of an electron acceptor, has an activity to maltose as low as 5% or less, and is inhibited by 1,10-phenanthroline. The invention also provides a method for producing the coenzyme-binding... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090176264 - Calibrator/control for simultaneous assay of proteins capable of complexing with one another: Disclosed herein are compositions and methods comprising two or more proteins in which at least one of the proteins has been altered to reduce their mutual recognition and binding. Such compositions are useful as reference, calibrators or controls in methods and assays for determining the amount of one or more... Agent: Philip S. Johnson Johnson & Johnson

20090176263 - Canis sphingosine 1-phosphate receptort isoform 1: A Canis sphingosine-1-phosphate (S1P) receptor isoform 1 (cS1P1), the nucleic acid encoding the cS1P1 receptor, and methods for using the cS1P1 receptor and the nucleic acid encoding the cS1P1 receptor in assays for identifying analytes which modulate activity of the cS1P1 receptor.... Agent: Merck And Co., Inc

20090176266 - Functional method to identify tastants: Provided are functional methods using the T1R2 monomer of the T1R2/T1R3 sweet receptor to identify agonists and modulators of the sweet taste response.... Agent: Curatolo Sidoti Co., Lpa

20090176267 - In vitro method for the identification and early identification and for the concomitant monitoring of the therapy of drug-and addictive substance-induced liver damage: Disclosed is an in vitro method for the identification and the concomitant monitoring of the therapy and cure of drug-induced or addictive substance-induced liver damage, in which the occurrence of the human enzyme carbamoyl synthase 1 (CPS 1) or its concentration is determined in serum or plasma samples from patients... Agent: Heslin Rothenberg Farley & Mesiti PC

20090176265 - Method of assessing biological test specimen: A method of assessing a biological test specimen includes the steps of detecting an acoustic emission produced by the biological test specimen and comparing the detected acoustic emission to a compilation of acoustic emissions produced by known biological sources. The method further includes the monitoring of various attributes of the... Agent: King & Schickli, PLLC

20090176268 - solid nutrient media useful for isolating and identifying alkaliphilic bacteria: The present invention relates to a solid nutrient media composition having alkaline pH, useful for isolating and identifying alkaliphilic microorganisms in pure form. Te media composition consists of 5-15 g of carbon source, 2.5-10 g of peptone, 2.5-10 g of yeast extract, 0.5-1.5 g of dipotassium hydrogen phosphate; 0.1-0.5 g... Agent: Luedeka, Neely & Graham, P.C.

20090176269 - Cell culture processes: Culturing heterologous protein-secreting mammalian cells, such as CHO or BHK cells, at 35.1-36.5° C. and/or at pH 7.15-7.20 and/or at a dissolved CO2 concentration of 10% or lower. Preferred heterologous proteins are Factor VIII, ADAMTS-13, furin or Factor VII.... Agent: Baxter Healthcare Corporation

20090176270 - Asymmetric cyanine fluorescent dyes, compositions and their use in staining biological samples: Asymmetric cyanine fluorescent dyes are represented by general formula I. These kinds of dyes may be used as a staining agent for nucleic acids, with the spectra at 600-900 nm in the near-infrared region and without interference from background fluorescence. These kinds of dyes may be useful with small-type red... Agent: Mindray C/o Stoel Rives LLP

20090176271 - Systems for efficient staining and sorting of populations of cells: A multi-channel apparatus for classifying particles according to one or more particle characteristics. The apparatus comprises a plurality of flow cytometry units, each of which is operable to classify particles in a mixture of particles by interrogating a stream of fluid containing the particles with a beam of electromagnetic radiation.... Agent: Santangelo Law Offices, P.C.

20090176272 - Expression of nucleic acid sequences for production of biofuels and other products in algae and cyanobacteria: Various embodiments provide, for example, vectors, expression cassettes, and cells useful for transgenic expression of nucleic acid sequences. In various embodiments, vectors can contain plastid-based sequences of unicellular photosynthetic bioprocess organisms for the production of food- and feed-stuffs, oils, biofuels, pharmaceuticals or fine chemicals.... Agent: Knobbe Martens Olson & Bear LLP

20090176275 - Expression system, components thereof and methods of use: Recently, the development of inducible expression systems has involved exploitation of the p-cym operon from Pseudomonas putida. Disclosed herein are novel expression systems and components thereof, which involve the development of a CymR variant with reverse DNA binding activity, such that they exhibit increased affinity for DNA in a presence... Agent: Kirby Eades Gale Baker

20090176274 - Glycosylated mammalian ngal and use thereof: The present invention relates to glycosylated mammalian NGAL, and methods of using said glycosylated mammalian NGAL.... Agent: Paul D. Yasger Abbott Laboratories

20090176273 - Production of lipidated proteins in e. coli: Production of a lipidated protein in an E. coli strain adapted to membrane protein expression.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090176276 - Fusion polypeptides of human serum albumin and a therapeutically active polypeptide: Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090176277 - Method for preparing cellulose derivatives having solubility improved: Provided is a method for preparing a cellulose derivative having solubility improved and therefore having less undissolved floating portions when the derivative is added into water. More specifically, provided is a method for preparing a cellulose derivative, comprising a step of depolymerizing a cellulose derivative to produce a depolymerized cellulose... Agent: Alston & Bird LLP

20090176278 - Solvents for mutant endoglycoceramidases with synthetic activity: The present invention provides reaction mixtures comprising a solvent having at least one of an alkoxy ether and/or a polyhydric alcohol for use in reactions with a mutant endoglycoceramidase having enhanced synthetic activity.... Agent: Townsend And Townsend And Crew, LLP

20090176279 - Bioreactive agents: This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise agents... Agent: Medlen & Carroll, LLP

20090176280 - Amplification and cloning of single dna molecules using rolling circle amplification: The present invention relates, e.g., to a method for amplifying a small number of copies (e.g. a single copy) of a single-stranded circular DNA molecule (e.g. having a size of about 5-6 kb) by an isothermal rolling circle mechanism, using random or partially random primers and a F29-type DNA polymerase.... Agent: Venable LLP

20090176282 - Device and method for thermal cycling: A thermal cycling device for performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray. The thermal cycling device includes a sample block assembly, an optical detection system, and a sample well tray holder configured to hold the sample well tray. The sample block... Agent: Invitrogen Corporation C/o Intellevate

20090176281 - Modular vector systems: The present invention provides improved techniques and reagents for producing nucleic acid molecules. In certain preferred embodiments, the nucleic acid molecules are modular vectors. In certain preferred embodiments, the nucleic acid molecules are produced in polymerase chain reactions employing terminator primer residues.... Agent: Choate, Hall & Stewart LLP

20090176283 - Method for the obtention of chimeric nucleotide sequences and chimeric nucleotide sequences: The present invention describes a method for producing synthetic nucleotide sequences which provides the assembly of DNA sequences, thus providing the obtention of genes, chromosomes and even whole qenomes. The method of the present invention makes use of the technique known as Polymerase Chain Reaction (PCR) but wherein no preexisting... Agent: Smith, Gambrell & Russell

20090176285 - Compositions and methods for enhancing glycerol utilization: A glycerol utilizing cell and a method for the production of glycerol-derived target compounds are provided. The glycerol utilizing cell may comprise a glycerol metabolizing system or a glycerol uptake protein and be used to produce a glycerol-derivable target compound.... Agent: Polsinelli Shughart PC

20090176284 - Process for preparing concentrated polyunsaturated fatty acid oil: The present invention provides a process for concentrated PUFA oil, characterized in that alcoholysis reaction using lipase is carried out in the presence of a small amount of water and at least one compound as an additive selected from magnesium oxide, magnesium hydroxide, calcium oxide and calcium hydroxide, and then... Agent: Fish & Richardson P.C.

20090176286 - Process for fractionating lignocellulosic biomass into liquid and solid products: The invention herein is an efficient, flexible biomass fractionation process comprising digesting a lignocellulosic-biomass material at about 120-220° C. and a pH of less than about 4, in an aqueous mixture containing an effective concentration of at least one solvent for lignin, and separating to recover a solid phase that... Agent: Gary C. Cohn, PLLC

20090176287 - Producing carotenoids: This document provides methods and materials related to the production of carotenoids. For example, microorganisms containing one or more exogenous nucleic acids and producing detectable amounts of carotenoids are provided.... Agent: Fish & Richardson P.C.

20090176288 - Methods and compositions for butanol production: A butanol producing cell and a method for the production of butanol are provided. Butanol producing cells comprising a butanol synthesis system or butanol export proteins may be used to enhance the production of butanol from a carbon substrate composition.... Agent: Polsinelli Shughart PC

20090176289 - Apparatus and process for the conversion into biogas of fermentation stillage arising as a waste product of ethanol production: The invention relates to an apparatus for the conversion into biogas of fermentation stillage arising as a waste product of ethanol production. This apparatus comprises a separation unit for the separation of the fermentation stillage into a thin fraction and a thick fraction, at least one biogas reactor for fermenting... Agent: Rankin, Hill & Clark LLP

20090176290 - Bacillus host cell: A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more secreted polypeptide(s) which is at least 80% identical to one or more of the polypeptides shown in SEQ ID NO's: 2... Agent: Novozymes North America, Inc.

20090176291 - Laundry detergent composition comprising a glycosyl hydrolase and a benefit agent containing delivery particle: The present invention relates to a laundry detergent composition comprising a glycosyl hydrolase and a benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions.... Agent: The Procter & Gamble Company Global Legal Department - Ip

20090176292 - Bgl7 beta-glucosidase and nucleic acids encoding the same: The present invention provides BGL7 polypeptides with the biological activity of a β-glucosidase and a method of producing a recombinant enzyme having β-glucosidase activity.... Agent: Victoria L. Boyd Genencor International, Inc.

20090176293 - Removal of plasmin(ogen) from protein solutions: A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms,... Agent: Jacobson Holman PLLC

20090176294 - Method for the submerged cultivation of filamentous organisms: A method for the submerged cultivation of filamentous organisms is described, where the formation of cell agglomerates, mycelial assemblages and pellets, and the adhesion to abiotic surfaces is reduced or prevented during the cultivation through the presence of particles which are insoluble or only partly soluble in the cultivation liquid... Agent: Roberts & Roberts, LLP Attorneys At Law

20090176295 - Use of mosses and/or lichens, element and method for reducing the particulate matter content of air: The invention relates to the use of mosses and/or lichens as agents for reducing the particulate matter content of air.... Agent: Collard & Roe, P.C.

20090176296 - Process for isolating nucleic acids: The present invention relates to a process for isolating total nucleic acid from a nucleic acid-containing sample and a kit for carrying out said process. More specifically, it relates to the isolation of RNA from a nucleic-acid containing sample.... Agent: Seed Intellectual Property Law Group PLLC

20090176297 - Device and method for treating biomass: A method for pretreating and disrupting cell structure of biomass by subjecting the biomass to high pressure, thereby disrupting the cell structure of the biomass is provided. Also provided is a device for performing the method, wherein the device includes a cavitating device and a cell structure disrupting device disposed... Agent: Warner Norcross & Judd LLP

20090176298 - Polymer compound for medical material, and biochip substrate using the polymer compound: The invention provides a polymer compound for medical material which is a polymer comprising repeating units derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for fixing a biologically active substance, wherein the polymer has a reactive functional group on at least one terminal side thereof, and... Agent: Smith, Gambrell & Russell

20090176299 - Species specific dna detection: The present invention relates to methods and compositions for the identification of species-specific material in pharmaceutical products. In particular, the present invention relates to methods for the identification of species-specific DNA in a population of a different species or following contact (e.g., growth) with cells of a different species.... Agent: Casimir Jones, S.c.

20090176300 - Method of and apparatus for converting biological materials into energy resources: A method of converting biological material into energy resources includes transmitting biological material to a pulsed electric field (PEF) station, and applying a PEF to the biological material within a treatment zone in the PEF station to generate treated biological material. The method also includes transmitting the treated biological material... Agent: Marshall, Gerstein & Borun LLP

20090176301 - Disposable spinner flask: A disposable spinner flask includes an asymmetric container, a lid, and a spinning mechanism. The container can be sealingly coupled to the lid, which includes an access port and a cap configured to be coupled to the access port for preventing bacteria, viruses, and fungi from passing therethrough while allowing... Agent: Seed Intellectual Property Law Group PLLC

20090176303 - Method and apparatus for propagating benthic marine invertebrates: An apparatus for propagating benthic marine invertebrates in water. The apparatus comprises (a) a culture cell, (b) a sedimentation chamber in fluid connection with the culture cell, and (c) a pump in fluid connection with the culture cell and with the sedimentation chamber capable of pumping water from the sedimentation... Agent: The Nath Law Group

20090176302 - Modified mite allergen and pharmaceutical uses thereof: The present invention provides a modified Dermatophagoides pteronyssinus allergen Der p 5 protein which has ability to inhibit IgE binding when exposed against to the antigen. A method for treating allergy comprising administrating a therapeutically effective dose of the modified D. pteronyssinus allergen Der p 5 protein to a subject... Agent: Wpat, PC Intellectual Property Attorneys

20090176304 - Method for in vivo, ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling: A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure. The application of external interval loading consisting of repeated periods of applied hydrostatic... Agent: Peters Verny , L.L.P.

20090176305 - Compounds and methods for treating breast cancer and other diseases: Disclosed are novel compositions and novel methods for the creation of both the novel compounds and known compounds. Also disclosed are methods for use of the novel compounds for treating a variety of diseases relating to decreasing or preventing activation of estrogen receptors and/or estrogen related receptors.... Agent: Perkins Coie LLP

20090176307 - Compounds, compositions and methods: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090176306 - Method of inducing differentiation from visceral preadipocyte to visceral adipocyte: The invention provides a method of inducing differentiation of a visceral preadipocyte and a method of culturing a visceral adipocyte comprising culturing the cell in a medium containing serum free of heparin-adsorbable components. The invention also provides for the removal of heparin-adsorbable components by, for example, applying serum to a... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

  
07/02/2009 > patent applications in patent subcategories. category listing

20090170059 - Methods for preparing cord matrix stem cells (cmsc) for long term storage and for preparing a segment of umbilical cord for cryopreservation: Methods and kits are provided for preparation of umbilical cord fragments and cells using autologous blood or blood products, and for storage of these materials with autologous cells and blood or blood products in containers having a plurality of separable chambers.... Agent: Lawson & Weitzen, LLP

20090170060 - Use of whole blood in pcr reactions: A method of obtaining DNA amplification of a nucleic acid target from a volume of whole blood comprising performing DNA amplification in a PCR assay mixture with a blood-resistant polymerase.... Agent: Sonnenschein Nath & Rosenthal LLP

20090170061 - Device comprising a sample of reconstructed tissue and a detection system: The present invention relates to a device (1) comprising: a sample of reconstructed tissue (4); and a detection system (20), (30) that is at least partially in contact with the tissue sample and/or with a device serving to culture said sample, said detection system making it possible to measure the... Agent: O'brien Jones, PLLC

20090170069 - Cell free methods for detecting protein-ligand binding: Provided are rapid and sensitive cell-free assay methods for detecting and/or measuring specific bimolecular or higher order interactions via reassembly of a split monomeric reporter protein, and methods of detecting or identifying modulators of such interactions by the effect on the signal provided by the reassembled split reporter protein. This... Agent: Greenlee Winner And Sullivan P C

20090170062 - Device and method for detecting analytes by visualization and separation of agglutination: The invention relates to a device for detecting one or several analytes in a sample, characterized in that it comprises one or more reaction chambers and/or one or more reagent application channels, and one or more capillary systems and one or more negative vessels. The invention also relates to a... Agent: Ratnerprestia

20090170072 - Device for collection and assay of oral fluids: A device for collecting and transporting aqueous fluid from the oral cavity to a lateral chromatographic strip for test is disclosed. The lateral chromatographic strip is placed within and extend along a cavity defined in a housing. At least one inspection site to the lateral chromatographic strip is provided to... Agent: Nixon Peabody, LLP

20090170063 - Hcv rna having novel sequence: A truncated form hepatitis C virus gene wherein part of the gene region encoding from the core protein to the NS2 protein of hepatitis C virus has been deleted while retaining the translation frame. In particular, the gene according to claim 1 wherein said part of the gene region is... Agent: Foley And Lardner LLP Suite 500

20090170070 - Increased specificity of analyte detection by measurement of bound and unbound labels: The present invention describes the provision of an internal control in analytical techniques involving labeling of analytes, such as SERRS, for detection of an analyte, particularly a biomolecule in a sample, with improved accuracy.... Agent: Philips Intellectual Property & Standards

20090170064 - Isothermal screening of human papillomavirus related nucleic acids: The presently described technology relates generally to the art of molecular diagnostics and more particularly to point-of-care diagnostic methods and materials. The diagnostic methods and materials of the presently described technology are suitable for a variety of uses including but not limited to the bedside or field diagnosis of infectious... Agent: Mcandrews Held & Malloy, Ltd

20090170065 - Method for transport of magnetic particles and devices therefor: The present invention is related to a method for re-enabling transport by means of a magnetic field gradient transport mechanism of magnetic beads comprising a ligand in a solution on top of a surface comprising a receptor bound with said ligand, comprising the step of changing the properties of said... Agent: Knobbe Martens Olson & Bear LLP

20090170066 - Methods and materials therefor: The present invention relates to a method for detecting or detecting and identifying rotavirus in a biological sample. In particular, the invention relates to a detection method comprising contacting the nucleic acids from the sample or derived from the sample with at least one VP4 and/or VP7 universal probes in... Agent: Glaxosmithkline Corporate Intellectual Property - Uw2220

20090170068 - Molecular identification through membrane-engineered cells: The present invention relates to the development of analytical devises based on one or more cells (cellular biosensors) the surface of which has been modified by the artificial insertion of molecules that can react specifically with analytes under determination. These receptor molecules may be proteins (such as enzymes, antigens or... Agent: Spiridon Kintzios

20090170071 - Serum biomarkers of hepatitis b virus infected liver and methods for detection thereof: The invention provides a method for detecting the presence of altered serum proteins in an Hepatitis B Virus (HBV)-infected patient with liver inflammation, comprising: obtaining a sample of serum from the patient; subjecting the sample to protein gel electrophoresis to separate proteins contained therein; staining proteins separated on the electrophoresis... Agent: Turocy & Watson, LLP

20090170067 - Simian tropic, recombinant human immunodeficiency-1 viruses: The present invention relates to a vector for producing recombinant human immunodeficiency virus 1 (HIV-1) that is capable of infecting simian cells and monkeys. The recombinant HIV-1 overcomes blocks to infection mediated by simian cell gene products. Such recombinant viruses are useful for evaluating the effectiveness of antiretroviral therapies and... Agent: Medlen & Carroll, LLP

20090170106 - Analysis of dna: The invention provides a method of investigating single nucleotide polymorphisms in a sample of DNA, the method comprising contacting the DNA containing sample with at least one first set of primers, amplifying the DNA using those primers to give an amplified product, contacting at least a portion of the amplified... Agent: Merchant & Gould PC

20090170098 - Antibodies to cell-cycle regulatory protein p16, and uses related thereto: The present invention relates to the discovery in eukaryotic cells, particularly mammalian cells, of a family of cell-cycle regulatory proteins (“CCR-proteins”). As described herein, this family of proteins includes a polypeptide having an apparent molecular weight of 16 kDa, and a polypeptide having an apparent molecular weight of approximately 15... Agent: Howrey LLP-ca

20090170100 - Biomarkers and detection methods for gastric diseases: The present invention provides a biomarker for detecting gastric diseases, especially gastric cancer selected from: a nucleic acid sequence of GroES, complementary strand, or derivatives thereof or an amino acid sequence of GroES, derivatives, fragments or variants thereof or antibodies against said amino acid sequences or combinations thereof, yet provides... Agent: Bacon & Thomas, PLLC

20090170104 - Compositions and methods for detecting group a streptococci: Compositions, methods and kits for detecting Group A streptococci. Particularly described are oligonucleotides that are useful as amplification primers and hybridization probes for detecting very low levels of Group A streptococci nucleic acids.... Agent: Gen Probe Incorporated

20090170110 - Compositions and methods to detect candida albicans nucleic acid: Compositions are disclosed as nucleic acid sequences that may be used as amplification oligomers, including primers, capture probes for sample preparation, and detection probes specific for Candida albicans 26S rRNA sequences or DNA encoding 26S rRNA. Methods are disclosed for detecting the presence of C. albicans in samples by using... Agent: Gen Probe Incorporated

20090170109 - Corn event tc1507 and methods for detection thereof: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize TC1507 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and... Agent: Mckee, Voorhees & Sease, P.L.C Attn: Pioneer Hi-bred

20090170107 - Detection assay for meat and bone meal in feed: The invention concerns methods, kits and nucleic acids involved in detecting animal tissues, for example processed animal proteins (PAPs) or meat and bone meal (MBM), especially in feeds. In one method, a nucleic acid such as DNA is extracted from a sample using a process involving incubating the sample in... Agent: Nixon & Vanderhye, PC

20090170105 - Diagnostics for aging-related dermatologic disorders: The present invention provides methods for the early prediction of aging-related dermatologic conditions of including skin changes associated with intrinsic aging or skin damages caused by extrinsic aging such as photoaging. The present invention also provides kits for the early determination of the propensity to develop such disorder and conditions.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090170094 - Fluorescent labeling substance comprising nanoparticles or nanorods: A fluorescent labeling substance that is capable of realizing highly appropriate labeling through enhancing of the luminous efficiency of semiconductor nanoparticles or nanorods. The fluorescent labeling substance can be provided by disposing on a surface of shell of nanorods or nanoparticles having a modification group capable of adsorption with a... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090170073 - Fluorescent protein and chromoprotein: It is an object of the present invention to provide a novel fluorescent protein and a novel chromoprotein. The present invention provides a novel fluorescent protein derived from Montipora sp., Acropora sp. and Lobophytum crassum, and a novel chromoprotein derived from Actinia equine.... Agent: Greenblum & Bernstein, P.L.C

20090170097 - Gene expression in biological conditions: The present invention relates to a method of predicting the prognosis of a biological condition in animal tissue, wherein the expression of genes is examined and correlated to standards. The invention further relates to the treatment of the biological condition and an assay for predicting the prognosis. In particular, the... Agent: Edwards Angell Palmer & Dodge LLP

20090170081 - Gene methylation in bladder cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with bladder cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of bladder cancer.... Agent: Townsend And Townsend And Crew, LLP

20090170084 - Gene methylation in breast cancer: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with breast cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of breast cancer.... Agent: Townsend And Townsend And Crew, LLP

20090170088 - Gene methylation in cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of cancer.... Agent: Townsend And Townsend And Crew, LLP

20090170087 - Gene methylation in cervical cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with cervical cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of cervical cancer.... Agent: Townsend And Townsend And Crew, LLP

20090170083 - Gene methylation in diagnosis of melanoma: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with melanoma. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of melanoma.... Agent: Townsend And Townsend And Crew, LLP

20090170086 - Gene methylation in esophageal cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with esophageal cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of esophageal cancer.... Agent: Townsend And Townsend And Crew, LLP

20090170085 - Gene methylation in head and neck cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with head and neck cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of head and neck cancer.... Agent: Townsend And Townsend And Crew, LLP

20090170082 - Gene methylation in renal cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with renal cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of renal cancer.... Agent: Townsend And Townsend And Crew, LLP

20090170111 - Genetic polymorphisms associated with stroke, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with vascular diseases, particularly stroke. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins,... Agent: Celera Corporation

20090170080 - Identification of beta-papillomavirus dna by type-specific reverse hybridization: The present invention relates human papilloma virus (HPV), more specific cutaneous, beta-PV. A method is disclosed for typing of any beta-PV nucleic acid with at least one probe capable of specific hybridization within the A region of beta-PV, said region being indicated in FIG. 1, and then analyzing beta-PV type(s)... Agent: Morrison & Foerster LLP

20090170101 - Identification of thymically derived cd4 t cells by protein tyrosine kinase 7 expression: The invention provides methods of identifying naïve T cells by expression of PTK7.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090170092 - Integrated microfluidic analysis systems: The present invention provides an integrated microfluidic analysis system. The system contains at least a first (pre-reaction treatment) domain for treating a sample prior to subjecting the sample to a chemical reaction. The following domains are optionally added to the first domain: a second (reaction) domain for reacting the chemical... Agent: Blank Rome LLP

20090170112 - Loci associated charcoal rot drought complex tolerance in soybean: The invention relates to methods and compositions for identifying soybean plants that are tolerant, have improved tolerance or are susceptible to Charcoal Rot Drought Complex. The methods use molecular genetic markers to identify, select and/or construct tolerant plants or identify and counter-select susceptible plants. Soybean plants that display tolerance or... Agent: Pioneer Hi-bred International, Inc.

20090170077 - Method for detecting recombinant event: Methods relating to isolating and amplifying chimeric nucleic acid molecules are provided. The methods of the invention are useful for detecting chromosome translocation events associated with diseases or conditions, such as cancer.... Agent: Goodwin Procter LLP Patent Administrator

20090170090 - Method for enhancing enzymatic dna polymerase reactions: The invention relates to a method of enhancing a DNA polymerase reaction by including in a reaction mixture containing a DNA polymerase a protein of DNA ligase.... Agent: Nixon & Vanderhye, PC

20090170091 - Method for predicting biological systems responses: The inventive method employs a “systems biology” approach to predicting biological responses resulting from exposure to the test substance. In one embodiment, the invention provides an automated method for predicting the biological systems effects of a test substance. In another embodiment, the invention provides a method for constructing a knowledgebase... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090170078 - Method of quantitatively analysing microorganism targeting rrna: An object of the present invention is to provide a method of quantitating or detecting a microorganism, capable of detecting a live microorganism at high sensitivity and more precisely. A method of quantitating a microorganism of interest, using as an index the amount of rRNA of the microorganism of interest... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090170089 - Methods and compositions for differentiating tissues or cell types using epigenetic markers: The present invention provides, inter alia, a method for generating a genome-wide epigenomic map, comprising a correlation between methylation variable CpG positions (MVP) and genomic DNA sample types. MVP are those CpG positions that show a variable quantitative level of methylation between sample types. Particular genomic regions of interest (ROI)... Agent: Davis Wright Tremaine, LLP/seattle

20090170102 - Methods for detecting dna originating from different individuals: In a first aspect, the present invention features methods for differentiating DNA species originating from different individuals in a biological sample. These methods may be used to differentiate or detect fetal DNA in a maternal sample or to differentiate DNA of an organ donor from DNA of an organ recipient.... Agent: Townsend And Townsend And Crew, LLP

20090170075 - Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer: The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090170095 - Mnk kinase homologous proteins involved in the regulation of energy homeostasis and organelle metabolism: The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis,... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090170113 - Non-invasive fetal genetic screening by digital analysis: The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies... Agent: Peters Verny , L.L.P.

20090170114 - Non-invasive fetal genetic screening by digital analysis: The present methods are exemplified by a process in which maternal blood containing fetal DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per reaction sample. Digital PCR is then be used to detect aneuploidy, such as the trisomy that causes Down Syndrome. Since aneuploidies... Agent: Peters Verny , L.L.P.

20090170096 - Nucleic acid amplification method: An object to be achieved by the present invention is to provide a nucleic acid amplification method by which a nucleic acid can be amplified substantially isothermally using oligonucleotide primers and DNA polymerase capable of strand displacement. The present invention provides a nucleic acid amplification method which comprises performing substantially... Agent: Birch Stewart Kolasch & Birch

20090170103 - Oligonucleotide sequences and dna chip for identifying filamentous microorganisms and the identification method thereof: A DNA chip for identifying filamentous microorganisms, including a substrate and a plurality of probes, wherein the probe includes SEQ ID No.1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, complementary sequences thereof, derivatives thereof or combinations thereof. The derivative is 5′ and/or... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20090170076 - Polynucleotides for the detection of escherichia coli 0157:h7 and escherichia coli 0157:nm verotoxin producers: Polynucleotide primers and probes for the specific detection of E. coli 0157:H7 and/or E. coli 0157:NM which produces verotoxin in samples are provided. The primers and probes can be used in real time diagnostic assays for rapid detection of E. coli 0157:H7 and/or E. coli 0157:NM which produces verotoxin. The... Agent: Foley & Lardner LLP

20090170079 - Regulation of runx1 for treatment of pain: Methods are provides for identifying candidate agents for use in inhibiting expression of certain receptors and ion channels in nociceptors. Also provided are methods for identifying candidates agents for use in inhibiting neurophathic and other types of pain.... Agent: Wolf Greenfield & Sacks, P.C.

20090170108 - Screening method, a composition comprising substances chosen in the method thereof, and a binding substance: (Means for Solving Problems) The present invention provides a screening method for selecting a test substance which strengthens a bond between a polypeptide of a thioredoxin family and a macrophage migration inhibition factor, comprising: mixing a test substance with at least one binding substance selected from following (1) to (4),... Agent: Law Offices Of Albert Wai-kit Chan, PLLC

20090170093 - Selection marker system and method for screening a choline tolerant plant cell: The present invention relates to a selection marker system for distinguishing genetically modified plant cells from wild-type plant cells comprising (a) a nucleic acid sequence coding for choline oxidase, choline monooxygenase and/or choline dehydrogenase for genetically modifying at least a part of a plant and; (b) at least a part... Agent: Viksnins Harris & Padys Pllp

20090170074 - System and method for nucleic acid sequencing by polymerase synthesis: This invention relates to improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single molecule detection of fluorescent labeled PPi moieties released from NTPs as a polymerase extension product is created.... Agent: Townsend And Townsend And Crew, LLP

20090170099 - Use of regulatory sequences for specific, transient expression in neuronal determined cells: The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliferative neuronal determined cells as well as for the... Agent: Fulbright & Jaworski L.L.P.

20090170121 - Assay buffer, compositions containing the same, and methods of using the same: Compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the invention relates to the use of novel combinations of reagents to provide improved assay performance.... Agent: Scully Scott Murphy & Presser, PC

20090170120 - Clinical correlates: A method of assessing an intracellular pathogen infection and/or monitoring an intracellular pathogen infection in an individual comprises determining whether the individual has (a) T-cells that secrete IFN-γ only, (b) T-cells that secrete IL-2 only or (c) T-cells that secrete both IFN-γ and IL-2 in response to an intracellular pathogen... Agent: Fulbright & Jaworski, LLP

20090170115 - Crohn's disease anitbody epitope peptide and reagent for testing crohn's disease: An epitope peptide is provided, which is capable of binding specifically to an antibody characteristic of Crohn's disease that is specifically observed in patients with Crohn's disease, together with a test method for conveniently and rapidly determining whether a subject is affected by Crohn's disease by use of the above... Agent: Fitch, Even, Tabin & Flannery

20090170118 - Formation and encapsulation of molecular bilayer and monolayer membranes: Disclosed herein are compositions, methods, and devices related to bilayer and monolayer membranes, their encapsulation in a hydrogel, and their formation. Methods of using the disclose compositions and devices are also disclosed.... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20090170116 - Il-13 production inhibitor: The present invention provides a screening method/screening kit for an IL-13 production inhibitor, which comprises using (a) a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, or its partial peptide, or a salt thereof; and (b)... Agent: Edwards Angell Palmer & Dodge LLP

20090170119 - Method for amplifying variation of frequency of signal in piezoelectrical biosensor: Provided is a method for amplifying a frequency variation of a detected signal in a biosensor that is used for detecting a biomolecule by measuring a change in frequency of an oscillating signal the change being caused by pressure a biomolecule applies to a piezoelectric substance. The method for amplifying... Agent: Cantor Colburn, LLP

20090170117 - Three-dimensional structure of fabk protein and method of developing a fabk protein inhibitor using the same: The present invention relates to a FabK (enoyl-acyl carrier protein reductase) protein derived from a Thermotoga maritima strain. In the present invention, the active site and the three-dimensional crystal structure of the protein are determined, a novel inhibitor against the FabK protein is screened and/or designed using the three-dimensional crystal... Agent: LexyoumeIPGroup, LLC

20090170122 - Human intestinal npt2b: A novel human sodium phosphate cotransporter expressed on the apical surface of intestinal epithelial cells (huNpt2B) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic... Agent: Roche Palo Alto LLC Patent Law Dept. M/s A2-250

20090170124 - Hydrogel thin film for use as a biosensor: The present disclosure provides a biosensor capable of producing an indicator response upon detection of the presence of certain metabolites in a biological sample. The biosensor includes a hydrogel that is functionalized with affinity molecules specific to markers for one or more pathogens. The biosensor also includes a detection system... Agent: Nellcor Puritan Bennett LLC Attn:IPLegal

20090170123 - Identification of novel protein targets on the surface of stressed cells: The present invention in the field of biochemistry and medicine is directed to novel methods for identifying molecules, typically proteins, that move to the cell surface when cells are stimulated or stressed can act as receptors even thought they are not transmembrane molecules and normally originate in the cytosol. Such... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090170129 - Detection of circulating endothelial cells: Endothelial cells are detected in a blood sample by enriching the endothelial cells from the blood sample followed by performing on the enriched endothelial cells an immunoassay capable of detecting antigens expressed by the endothelial cells. The immunoassay is capable of detecting antigen expressed from 300 endothelial cells per milliliter... Agent: Wellstat Management Company. LLC

20090170131 - Agents for imaging apoptosis: Compositions, and methods of using such compositions, having the following Formula (I) or salt, ester, or hydrate thereof, wherein R1 is Asp-Glu peotide, tert-butyloxycarbonyl, methoxyphenylacetyl, bromomethoxyphenylaceityl, fluoromethoxyphenylacetyl, (methylmethoxyphenyl)acetyl, or iodomethoxyphenylacetyl; R2 is valine with or without protecting groups), aspartale (with or without protecting groups), 1-Butyl, hydrogen, aniline, aromatic molecules, tert-butyloxycarbonyl,... Agent: Baker Botts, LLP

20090170132 - Methods for detecting colon carcinoma: The present invention provides methods for diagnosing carcinoma, providing a prognosis for a carcinoma or assessing the likelihood that a tissue may become cancerous by identifying the presence or absence of or determining the amount of one or more carcinoma associated markers. Further, the present invention provides methods for determining... Agent: Klauber & Jackson

20090170130 - Phosphospecific chemokine receptor antibodies: The present invention provides chemokine receptor antibodies that selectively bind to an activated form of the receptor but not to a non activated form of the receptor. In particular, the current invention provides phospho specific chemokine receptor antibodies. The antibodies can be used in several diagnostic, screening and purification methods.... Agent: Polsinelli Shughart PC

20090170125 - Cellular assay method for identifying pkc-0 inhibitors: e

20090170126 - Prostasin partial peptide and anti-prostasin antibody: An object of the present invention is to provide an antibody that can be stably supplied and can react with prostasin under non-denaturation and denaturation conditions, and an antigen peptide for preparation of the antibody. The present invention relates to a peptide consisting of the amino acid sequence shown in... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090170128 - Crystallization and structure determination of bace and/or bace-like proteins: The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of human BACE activity.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090170127 - Screening compounds for activity in modulating chloride ion transport: A method for screening a test compound for activity in modulating the activity of the chloride channel ClC-7 either directly or by modulating the subcellular localization of Ostm1 comprises determining whether test compound inhibits the binding of Ostm1 to ClC-7. Compounds active in the screen are candidates for use in... Agent: Edwards Angell Palmer & Dodge LLP

20090170134 - Bifunctional and trifunctional nitrone spin trapping compounds and uses thereof: Methods and compositions for detecting free radicals, the compositions being spin trapping compounds comprising a nitrone having a detecting moiety and optionally having a targeting moiety for targeting the nitrone to an organ, a cell, an organelle or a molecule of interest for directly detecting free radicals, especially free radicals... Agent: Quarles & Brady LLP

20090170137 - Determining canine probnp: Methods and compositions are disclosed for determining canine proBNP or fragments thereof in a sample. In one method, canine proBNP or fragments thereof are determined by providing a canine sample, contacting the sample with at least one antibody that binds an epitope in the region from amino acids 1 to... Agent: Fulbright & Jaworski L.L.P.

20090170138 - Determining canine probnp: Methods and compositions are disclosed for determining canine proBNP or fragments thereof in a sample. In one method, canine proBNP or fragments thereof are determined by providing a canine sample, contacting the sample with at least one antibody that binds an epitope in the region from amino acids 32 to... Agent: Fulbright & Jaworski L.L.P.

20090170135 - Determining feline probnp: Methods and compositions are disclosed for determining feline proBNP or fragments thereof in a sample. In one method, feline proBNP or fragments thereof are determined by providing a feline sample, contacting the sample with at least one antibody that binds an epitope in the region from amino acids 1 to... Agent: Fulbright & Jaworski L.L.P.

20090170136 - Determining feline probnp: Methods and compositions are disclosed for determining feline proBNP or fragments thereof in a sample. In one method, feline proBNP or fragments thereof are determined by providing a feline sample, contacting the sample with at least one antibody that binds an epitope in the region from amino acids 68 to... Agent: Fulbright & Jaworski L.L.P.

20090170133 - Intact igfbp-3 as a colon cancer risk factor in patients with inflammatory bowel disease: The subject invention provides a method for determining whether a human subject afflicted with long-lasting irritable bowel disease (IBD) has an increased risk for developing colon cancer comprising: (a) determining the concentration of intact IGFBP-3 in a suitable cell-free bodily fluid sample taken from the subject; and (b) determining whether... Agent: Cooper & Dunham, LLP

20090170139 - Method, reagent and kit for measurement of cholesterol in remnant-like particles: The present invention provides a method for simple and accurate measurement of cholesterol in remnant-like lipoprotein (RLP) (RLP-C) in a sample, which comprises the steps of: (i) eliminating cholesterol in lipoproteins other than RLP by reacting the sample with cholesterol oxidase, or cholesterol dehydrogenase and oxidized coenzyme, in an aqueous... Agent: Fitzpatrick Cella Harper & Scinto

20090170140 - Blood urea nitrogen (bun) sensor: A BUN (blood urea nitrogen) sensor containing immobilized carbonic anhydrase and immobilized urease for the in vitro detection of urea nitrogen in blood and biological samples with improved performance and precision characteristics.... Agent: Katten Muchin Rosenman LLP (c/o Patent Administrator)

20090170141 - Ghrelin o-acyltransferase (goat) biochemical assay: Ghrelin is acylated ghrelin O-acyltransferase. Ghrelin O-acyltransferase assays comprise contacting a mixture of ghrelin and recombinant ghrelin O-acyltransferase with an agent; and detecting a resultant decrease in acylation of the ghrelin by the acyltransferase.... Agent: Richard Aron Osman

20090170142 - Use of 4'-phosphopantetheinyl transferase as a target for identifying antibiotic molecules: The present invention pertains to the use of a PptT protein, as a target for screening compounds for identifying those having an antibiotic activity, especially against a pathogenic bacterium containing mycolic acids. The invention also concerns an in vitro screening process for identifying compounds having an antibiotic activity, by measuring... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090170143 - Determination of neutrophil gelatinase-associated lipocalin (ngal) as a diagnostic marker for renal disorders: Methods for diagnosing renal disorders by measuring human neutrophil gelatinase-associated lipocalin (NGAL) are provided.... Agent: Licata & Tyrrell P.C.

20090170144 - Determination of viable microorganisms using coated paramagnetic beads: The present invention relates to methods for the detection of microorganisms. In one embodiment, the present invention provides methods for detecting live microorganisms in a culture by capturing and culting the microorganisms on para-tropic-coated paramagnetic beads. This technique is useful for any application in which it is necessary to monitor... Agent: Frost Brown Todd, LLC

20090170145 - Modified creatinine amide hydrolase having improved affinity for substrate, and reagent composition for determination of creatinine: e

20090170146 - Novel carboxylesterase nucleic acid molecules, proteins and uses thereof: The present invention relates to arthropod esterase proteins; to arthropod esterase nucleic acid molecules, including those that encode such esterase proteins; to antibodies raised against such esterase proteins; and to other compounds that inhibit arthropod esterase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules,... Agent: Sheridan Ross P.C.

20090170147 - Forensic test kit and method for the detection of semen: The present invention relates to a forensic test kit and method for the detection of semen. This kit is comprised of two main components: acid phosphatase (AP) test strips and prostate specific antigen (PSA) test strips, which work together to provide evidence of semen on fabrics and other surfaces. The... Agent: Stephen P. Ashburn

20090170148 - Nanog+, oct-4+ retinal pigment epithelial stem cells and methods for their use and manufacture: Retinal stem cells haying embryonic-like characteristics are disclosed. The retinal stem cells express one or more of the embryonic stem cell markers Nanog and OCT-4. The retinal stem cells may be obtained from retinal pigment epithelium. Methods of making and using retinal stem cells are also disclosed.... Agent: Stemedica Cell Technologies, Inc

20090170149 - Photo-acoustic detection device and method: An example system for detecting an analyte in a sample of a bodily fluid comprises a test chamber having at least one sidewall and configured to contain at least a portion of a bodily fluid sample, an excitation electromagnetic energy source configured to direct an energy source into the test... Agent: Greer, Burns & Crain

20090170150 - Screening assay for ribosomal antibiotics: The present invention is directed to a method for identifying ribosomal antimicrobial substances being selective for microbial but not for mitochondrial and/or cytosolic ribosomes. Specifically, said method is directed to an assay that compares the interaction of a candidate ribosomal antimicrobial substance (i) in a bacterial strain with microbial ribosomes,... Agent: The Nath Law Group

20090170151 - Flow-through cell and method of use: There is disclosed a flow-through cell comprising a substrate defining a channel, having an inlet and an outlet, at least a portion of the substrate being light-permeable to allow particles within at least a portion of the channel between the inlet and the outlet to be optically detected through the... Agent: Nixon & Vanderhye, PC

20090170152 - Tissue conditioning protocols: Solutions exhibiting little or no evaporative loss at elevated temperatures, i.e., in excess of 100° C., are employed in place of conventional aqueous-based antigen retrieval solutions.... Agent: Runyan Law C/o Intellevate LLC

20090170153 - Effect of radiation on cellulase enzymes: A method for recycling cellulase enzymes. Also provided is a method for producing fermentable carbohydrates, plant leaf protein, and lignin, by adding a cellulase enzyme complex expressed from and on irradiated cellulase complex-producing organisms with sufficient radiation to kill biological activity without destroying all cellulase enzyme complex activity to biomass.... Agent: Warner Norcross & Judd LLP

20090170157 - Asparaginases: The invention relates to new asparaginases having improved properties, preferably improved thermotolerance, such as improved activity at high temperatures and/or improved thermostability. The invention also relates to DNA sequences encoding such improved asparaginases, their production in a recombinant host cell, as well as methods of using the asparaginases, in particular... Agent: Novozymes North America, Inc.

20090170160 - Expression system: A perfect palindrome operator sequence-based protein expression system is provided. The expression system comprises a promoter; and a perfect palindrome operator sequence, wherein the promoter is not T7. The expression system is preferably employed for the production of recombinant proteins by fermentation.... Agent: Morgan Lewis & Bockius LLP

20090170161 - Gdep enhancer element and use thereof to confer retinal specific gene expression: The present invention is directed to isolated nucleic acids containing functional polynucleotide sequences representing an enhancer element for the Gene Differentially Expressed in Prostate (GDEP). Such molecules are useful in conferring retinal specific transcriptional responsiveness on associated promoters and methods for directing retinal specific gene expression are accordingly disclosed.... Agent: Quarles & Brady LLP

20090170156 - Hydroxynitrile lyase: An improved hydroxynitrile lyase characterized by having a mutation of substitution of at least one amino acid residue in the amino acid sequence of a wild-type hydroxynitrile lyase with another amino acid and by its hydroxynitrile lyase activity per transformant being higher than the hydroxynitrile lyase activity per transformant into... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090170154 - Mutant bacterium belonging to the genus bacillus: A mutant Bacillus bacterium which has, on the genome or plasmid thereof, DNA having a promoter sequence which is recognized and transcribed specifically during the sporulation stage and which is ligated to an upstream end of a sigA gene or a gene equivalent thereto, a recombinant microorganism produced by introducing... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090170155 - Mutant endoglycoceramidases with enhanced synthetic activity: The present invention relates to a novel endoglycoceramidase whose hydrolytic activity has been substantially reduced or eliminated, such that the enzyme is useful for synthesis of glycolipids from a monosaccharide or oligosaccharide and a ceramide. More specifically, the endoglycoceramidase is a mutant version of a naturally occurring endoglycoceramidase, preferably comprising... Agent: Townsend And Townsend And Crew, LLP

20090170159 - Production of glycoproteins with reduced o-glycosylation: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.... Agent: Merck And Co., Inc

20090170158 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to... Agent: Brinks Hofer Gilson & Lione

20090170162 - Non-coiled protective regions of pneumococcal surface proteins pspa and pspc: The embodiments described herein provide for immunogenic portions of Streptococcus pneumoniae surface protein A and surface protein C lacking alpha helical structure.... Agent: Nixon Peabody, LLP

20090170163 - Spacers to increase the expression of recombinant fusion proteins: The present invention relates to fusion proteins. The invention specifically relates to compositions and methods of Tf-based fusion proteins that demonstrate a high-level expression of transferrin (Tf)-based fusion proteins by inserting a helical linker between two protein domains.... Agent: Hogan & Hartson L.L.P.

20090170165 - Method for recombinant production in cho cells: We describe a Cricetulus griseus cell which is modified, preferably genetically engineered, so that the expression of a heat shock protein is up-regulated compared to a cell which has not been so modified, as well as a method of expressing a recombinant protein from a host comprising such an engineered... Agent: David S. Resnick

20090170164 - Recombinant protein production in a human cell: Methods and compositions for the production of recombinant proteins in a human cell line. The methods and compositions are particularly useful for generating stable expression of human recombinant proteins of interest that are modified post-translationally, for example, by glycosylation. Such proteins may have advantageous properties in comparison with their counterparts... Agent: Traskbritt, P.C.

20090170166 - Antibody inhibiting uracil-dna-glycosylase and uses thereof for decontaminating nucleic acid amplification reactions: The invention concerns antibodies directed against the uracil-DNA-glycosylase inhibitor, and uses thereof for decontaminating nucleic acid amplification reactions.... Agent: Alston & Bird LLP

20090170168 - Method for making available a priming oligonucleotide: The present invention is directed to novel methods of synthesizing multiple copies of a target nucleic acid sequence which are autocatalytic (i.e., able to cycle automatically without the need to modify reaction conditions such as temperature, pH, or ionic strength and using the product of one cycle in the next... Agent: Gen Probe Incorporated

20090170167 - Single enzyme system for fast, ultra long pcr: The present invention provides methods, formulation and kits for the synthesis of long nucleic acid fragments. An improved PCR method is provided for amplifying long DNA fragments. In particular, a single thermostable DNA polymerase is used for the rapid amplification of over 10 kb long DNA fragments. Also provided is... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20090170169 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the rspab operon: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the rspAB operon.... Agent: Cermak & Kenealy LLP Acs LLC

20090170170 - P2-10 expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090170171 - Method of producing l-serine derivative and enzyme used therefore: e

20090170172 - Recombinant methods and materials for producing epothilone and epothilone derivatives: Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) are used to express recombinant PKS genes in host cells for the production of epothilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.... Agent: Fox Rothschild LLP Bristol-myers Squibb

20090170173 - Nucleic acid molecules encoding polypeptides involved in regulation of sugar and lipid metabolism and methods of use viii: This invention relates generally to nucleic acid sequences encoding proteins that are related to the presence of seed storage compounds in plants. More specifically, the present invention relates to Arabidopsis thaliana, Brassica napus, Glycine max and Oryza sativa nucleic acid sequences encoding sugar and lipid metabolism regulator proteins and the... Agent: Connolly Bove Lodge & Hutz, LLP

20090170174 - Glucose conversion to ethanol via yeast cultures and bicarbonate ions: The present invention is directed to the enhanced production of ethanol from fermentation using an ethanol producing microorganism. In particular, the present invention provides a process for the enhanced growth and metabolism of an ethanol producing microorganism (e.g., yeast), for the purpose of increasing or enhancing ethanol production, both in... Agent: Stephen Shear Law Department

20090170175 - Procedure and arrangement for toasting corn and the product obtained to be applied in the preparation of mash for ethyl fermentation: A procedure to turn the starch contained in corn grains to soluble forms includes seven steps, starting a first step in which the corn that comes from a hopper is placed into a rotary and continuous oven for its toasting, characterized because it also links a second step in which... Agent: Bachman & Lapointe, P.C.

20090170176 - Microorganism having the improved gene for hydrogen generation capability, and process for producing hydrogen using the same: Utilization of the microorganism of the present invention enables the hydrogen production from an organic substrate to be accomplished on a practical, commercial scale. The hydrogen to be produced by the present invention, which is free of carbon monoxide being causative to poisoning of the electrode catalyst for fuel cells,... Agent: Nixon & Vanderhye, PC

20090170177 - Stem cell transfection method: Stem cell transfection method. The stem cell infection method of the invention comprises providing a stem cell; positioning the stem cell at a buffer, wherein the buffer contains a foreign material; electroporating the stem cell in the buffer; and culturing the stem cell.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20090170178 - Cell stimulating device and cell stimulating method: It is an object of the present invention to provide an electrical stimulating device for efficiently providing direct electrical stimulation to a large number of nerve cells in vitro without causing any injuries to such cells. The present invention provides a cell stimulating device which comprises: a first electrode serving... Agent: Greenblum & Bernstein, P.L.C

20090170179 - Covalent assembly of ultrathin polymeric films: In one aspect, described herein are ultrathin films comprising an azlactone functionalized polymer and a primary amine functionalized polymer. Also described herein are ultrathin films including reactive, nonreactive, partially reactive/nonreactive, hydrophobic, hydrophilic, and mixed hydrophobic/hydrophilic ultrathin films. In another aspect, described herein are methods for making surface attached and freestanding... Agent: Greenlee Winner And Sullivan P C

20090170180 - Immobilization of biocatalysts by template-directed silicate precipitation: This invention relates to a method of immobilizing biocatalysts including protein and cells by co-precipitation with silicate or organosilicate matrices through the action of an organic template molecule. The organic template molecule is in general a polyamine such as polyethylenimine (PEI), or polypeptide compound bearing at least two or three... Agent: Howrey LLP-ca

20090170181 - Egvii endoglucanase and nucleic acids encoding the same: The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same.... Agent: Victoria L. Boyd Genencor International, Inc.

20090170182 - Lopap-based pharmaceutical compositions and uses thereof: The invention refers to pharmaceutical compositions and cosmetic compositions comprising a prophylactic or therapeutically effective quantity of at least one polypeptide substantially identical to Lopap (a lipocalin-related protein with prothrombin activating protease activity). The invention refers to the use of these compositions as modulators of cell death and anti-aging agents.... Agent: Fish & Richardson PC

20090170183 - Microtiter plate and use thereof: The invention relates to a microtiter plate and use thereof for conducting fermentation under fed-batch conditions. In order to produce a microtiter plate which permits screening under fed-batch conditions, the invention proposes that the cavities (2) of the microtiter plate according to the invention be filled with a culturing fluid... Agent: Cohen, Pontani, Lieberman & Pavane LLP

20090170184 - System for fermentation using algae: The system for fermentation using algae of the present invention includes a first reactor and a second reactor being in fluid communication with each other. A first valve placed between the first reactor and the second reactor controls the fluid connection between the reactors. A gas inlet, in fluid connection... Agent: Egbert Law Offices

20090170185 - Cholesterol absorption inhibitor: To provide a bacterium belonging to the genus Bifidobacterium which is excellent in a survival ability in the gastrointestinal tract, has an effect of inhibiting the cholesterol absorption in the intestinal tract, and is excellent in lipid metabolism ameliorating effects including decreasing the blood cholesterol level and the like, and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090170186 - Optoelectronic tweezers for microparticle and cell manipulation: An optical image-driven light induced dielectrophoresis (DEP) apparatus and method are described which provide for the manipulation of particles or cells with a diameter on the order of 100 μm or less. The apparatus is referred to as optoelectric tweezers (OET) and provides a number of advantages over conventional optical... Agent: John P. O'banion O'banion & Ritchey LLP

20090170187 - Apparatus for determining the presence of a contaminant in a sample of water or other fluid: Apparatus for testing the quality of a fluid sample, the apparatus comprising a main body including a plurality of sample compartments, characterised in that the apparatus further comprises a contaminant reagent retention means arranged to retain a plurality of doses of contaminant reagent within the apparatus and arranged to allow... Agent: Marshall, Gerstein & Borun LLP

20090170188 - Diagnostic sanitary test strip: An improved multi-layered diagnostic sanitary test strip for receiving a heterogenous fluid, such as whole blood, to test for presence and/or amount of a suspected analyte in the fluid by facilitating a color change in the strip corresponding to the amount of the analyte in the fluid, wherein the test... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090170189 - Microfluidic device and method of fabricating the same: Provided are a microfluidic device that performs a biochemical reaction using a small amount of a biochemical fluid and detects the result thereof, and a method of fabricating the same. The microfluidic device includes: a substrate which comprises a chamber that is formed as a concave groove and accommodates a... Agent: Sughrue Mion, PLLC

20090170190 - Cell culture container and method of producing the same: An object of the present invention is to provide a cell culture chamber with which the survival rate of cells to be cultured can be increased, and a method of producing the same. A cell culture chamber according to the present invention includes a mass of projections formed of a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090170191 - 84p2a9: a prostate and testis specific protein highly expressed in prostate cancer: A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, breast, pancreas, colon, lymphocytic and lung cancers. Consequently, 84P2A9 provides a diagnostic and/or... Agent: Agensys C/o Morrison & Foerster LLP

20090170192 - Methods and dna constructs for high yield production of polypeptides: The invention provides an inclusion body fusion partner to increase peptide and polypeptide production in a cell.... Agent: Campbell Nelson Whipps, LLC

20090170193 - Stem cells: The present invention relates to an isolated stem cell population wherein said stem cells are CD34+, capable of self regeneration, capable of differentiation into ectodermal, mesodermal and endodermal cells and capable of adhering to tissue-culture grade plastic as well as to methods of isolation of said cells, methods of culturing... Agent: Knobbe Martens Olson & Bear LLP

20090170194 - Teal fluorescent proteins: An isolated nucleic acid sequence encoding a non-oligomerizing Clavularia teal fluorescent protein (TFP) variant having a tyrosine-derived chromophore, and fragments and derivatives thereof. Also provided is a method for engineering the nucleic acid sequence, a vector comprising the nucleic acid sequence, a host cell comprising the vector, and use of... Agent: Edward Yoo C/o Bennett Jones

20090170196 - Cancer treatment using c-type natriuretic peptide: The present invention includes a method of utilizing four peptide hormones to inhibit the growth of cancer(s). A dramatic decrease in the number of human pancreatic adenocarcinoma cells (i.e., the type of cancer with the highest mortality, with patients only surviving four months) was observed responsive to treatment. The application... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090170195 - Curcumin-hyaluronan compounds: A dissociable complex is disclosed. The dissociable complex includes at least one molecule of curcumin, at least one molecule of hyaluronic acid, and at least one linker molecule, wherein a first portion of the linker molecule is bonded to the curcumin and a second portion of the linker molecule is... Agent: Hahn Loeser & Parks, LLP

20090170198 - Differentiation of human embryonic stem cells: The present invention provides methods to promote the differentiation of pluripotent stem cells and the products related to or resulting from such methods. In particular, the present invention provides an improved method for the formation of pancreatic hormone expressing cells and pancreatic hormone secreting cells. In addition, the present invention... Agent: Philip S. Johnson Johnson & Johnson

20090170197 - Nucleic acid-mediated treatment of diseases or conditions related to levels of vascular endothelial growth factor receptor (vegf-r): The present invention relates to nucleic acid molecules such as ribozymes, DNAzymes, short interfering RNA (siRNA), short interfering nucleic acid (siNA), and antisense which modulate the synthesis, expression and/or stability of an mRNA encoding one or more receptors of vascular endothelial growth factor, such as flt-1 (VEGFR1) and/or KDR (VEGFR2).... Agent: Mcdonnell, Boehnen, Hulbert And Berghoff, LLP

20090170199 - Separation and sorting of different biological objects: The present invention relates to a method for the separation of biological objects in a solution which have different viscoelastic properties, wherein said method comprises a filtration step allowing the higher viscoelastic biological objects to pass through the membrane while retaining the lower viscoelastic biological objects above the membrane, and... Agent: Foley And Lardner LLP Suite 500

20090170201 - Compositions and methods of making embryonic stem cells: The invention relates to cell proliferation, cell differentiation, male infertility, male fertility and to compositions and methods involved therein.... Agent: K&l Gates LLP

20090170200 - Stem cell medium: A medium for culturing stem cell. The stem cell medium of the invention comprises a fetal bovine serum, one or plurality of amino acid, one or plurality of vitamin, one or plurality of growth factor, one or plurality of inorganic salt, one or plurality of antioxidant, wherein the stem cell... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20090170202 - Nucleic acids that enhance the synthesis of 2-acetyl-1-pyrroline in plants and fungi: The aromatic compound 2-acetyl-1-pyrroline-is the major potent flavor component of all aromatic rice. This present invention provides transgenic rice plants in which 2-acetyl-1-pyrroline is synthesized at a level greater than in naturally occurring non-aromatic varieties. The transgenic plants have reduced expression of the Os2AP gene and protein, resulting in an... Agent: Morrison & Foerster LLP

20090170205 - Method of maintenance and expansion of hematopoietic stem cells: [Solving Means] A method of maintaining/expanding hematopoietic stem cells, comprising culturing hematopoietic stem cells in the presence of the HSC activity supporting factor of the present invention, which comprises the same or substantially the same amino acid sequence as an amino acid sequence shown by SEQ ID NO:2 or 4,... Agent: Leydig Voit & Mayer, Ltd

20090170203 - Methods for female mammalian spermatogenesis and male mammalian oogenesis using synthetic nanobiology: Herein are disclosed methods for producing female sperm by incorporating a female's chromosomes into a sperm cell via mostly natural spermatogenesis processes. The methods include transplanting (altered) female stem cells or (altered) cloned germ cells into sterilized testes of a male. Diploid female stem/germ cells are altered in two ways—transdifferentiation... Agent: David P. Lentini

20090170204 - Novel cosmetic designs and products using intronic rna: The present invention relates to a method and composition for generating a non-naturally occurring intron and its components capable of being processed into small hairpin RNA (shRNA) and/or microRNA (miRNA) molecules by skin cells and thus inducing specific gene silencing effects on skin pigment-related genes and/or aging-causing genes in the... Agent: Birch Stewart Kolasch & Birch

20090170206 - Method for homologous recombination in eukaryotic cells: We disclose a method to construct eukaryotic cells having a target sequence in a chromosomal DNA sequence replaced by a desired replacement sequence, comprising: modifying a parent eukaryotic cell with a preference for NHR to provide a eukaryotic cell having an increased HR/NHR ratio as compared to the parent cell,... Agent: Nixon & Vanderhye, PC

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