|Chemistry: molecular biology and microbiology patents - Monitor Patents|
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Chemistry: molecular biology and microbiology May archived by USPTO category 05/09Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 05/28/2009 > patent applications in patent subcategories.
20090136912 - Carrier for cell culture: A carrier for cell culture is provided which improves the cell proliferativity in serum-free culture and which is free from risk from infection factor contamination. The gist of the features of the present invention is to be formed of a crosslinked poly (meth) acrylic acid (salt) particle (A) and an... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20090136913 - Gravity-assisted mixing methods: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090136914 - Identification and use of genes encoding holins and holin-like proteins in plants for the control of microbes and pests: This invention provides: 1) methods for the identification of broad-spectrum holins with a high level of nonenzymatic activity in membranes; 2) conditions required for maintaining and increasing the anti-microbial and anti-pest efficacy of holins in gene fusions; 3) a method for effective targeting of holins expressed in plants through use... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090136915 - Methods and compositions for determining altered susceptibility of hiv-1 to anti-hiv drugs: This invention relates, in part, to methods and compositions for determining altered susceptibility of a human immunodeficiency virus (“HIV”) to the non-nucleoside reverse transcriptase inhibitors (“NNRTIs”) efavirenz (“EFV”), nevirapine (“NVP”), and delavirdine (“DLV”), the nucleoside reverse transcriptase inhibitor AZT, and the integrase strand transfer inhibitors diketo acid 1, diketo acid... Agent: Jones Day
20090136916 - Methods and microarrays for detecting enteric viruses: The present invention relates to methods, microarrays and kits for detecting one or more human astrovirus serotypes in a sample (e.g., a fecal sample) from an individual. The method includes amplifying nucleic acid molecules of the sample with one or more primers, to thereby obtain an amplified nucleic acid product;... Agent: Michael Best & Friedrich LLP
20090136917 - Systems and methods for viral therapy: Diagnostic methods and compositions associated with viral therapy are provided. In particular, methods, compositions, and kits to measure markers and therapeutic indicator predictive of viral efficacy in antitumor therapy are provided. Therapeutic viruses and combinations and kits for use in the practicing the methods also are provided.... Agent: K&l Gates LLP
20090136956 - use of dual-tags for the evaluation of genomic variable repeat regions: The methods and compositions of the present invention allow for the evaluation of a nucleotide expansion, contraction or deletion. In one embodiment, the present invention provides a method for detecting a nucleotide expansion, contraction or deletion comprising amplifying a target nucleic acid sequence with a primer pair, each primer comprising... Agent: Fulbright & Jaworski L.L.P.
20090136944 - Aberrantly methylated genes as markers of breast malignancy: The invention is directed to a method of diagnosing a cell proliferative disorder of breast tissue by determining the methylation status of nucleic acids obtained from a subject. Aberrant methylation of several genes including TWIST, HOXA5, NES-1, retinoic acid receptor beta (RARβ), estrogen receptor (ER), cyclin D2, WT-1, 14.3.3 sigma,... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper LLP (us)
20090136942 - Analysis of extracellular rna: The invention provides methods for detecting tumor-associated RNA in plasma, serum, and other bodily fluids. In particular, the invention provides methods for detecting translocated gene RNA, including fusion gene RNA, in plasma or serum or other bodily fluids.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090136921 - Association of breast cancer dna methylation profiles with hormone receptor status and response to tamoxifen: Particular embodiments provide novel and clinically useful DNA methylation predictors of hormone receptor status, and predictors of response to endocrine (e.g., hormonal) and non-endocrine breast cancer therapy. The ESR1 gene, encoding the estrogen receptor (ER) alpha proved to be the preferred predictor of progesterone receptor (PR) status, while methylation of... Agent: Davis Wright Tremaine, LLP/seattle
20090136946 - Automated enumeration and characterization of circulating melanoma cells in blood: The CellTracks® System provides a system to enumerate circulating melanoma cells in blood. The system immunomagnetically concentrates epithelial cells, fluorescently labels the cells and identifies and quantifies circulating melanoma cells. The absolute number of circulating melanoma cells detected in the peripheral blood tumor load is, in part, a factor in... Agent: Philip S. Johnson Johnson & Johnson
20090136958 - Capture, recapture, and trapping of molecules with a nanopore: In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopore, from one of the two fluidic reservoirs to the other... Agent: Theresa A Lober T.a. Lober Patent Services
20090136945 - Compositions and methods for assessing disorders: The present invention relates to compositions and methods for disorder (e.g., hyperproliferative disorders, inflammatory disorders) research, diagnosis, and treatment, including but not limited to, bio-markers specific for a particular disorder (e.g., cancer, systemic lupus erythematosus). In particular, the present invention relates to peripheral blood mononuclear cells (PBMCs) as bio-markers specific... Agent: Casimir Jones, S.c.
20090136928 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Goodwin Procter LLP Attn: Patent Administrator
20090136926 - Device and method for standardizing nucleic acid concentrations: The present invention relates to a device and a method for normalising nucleic acid concentrations, preferably for normalising nucleic acid concentrations in enzymatic nucleic acid amplification and modification methods.... Agent: Mcdermott Will & Emery LLP
20090136962 - Diagnostic markers for cancer: The present invention provides compositions and methods useful for diagnosing cancer and for monitoring the progression and treatment of cancer, as well as targets for treating cancer. The invention provides sperm and testis associated antigens, such as the protein CABYR, as biomarkers and as targets for chemotherapy.... Agent: Barnes & Thornburg LLP
20090136920 - Diagnostics and therapeutics for diseases associated with serum/glucocorticoid regulated kinase 1 (sgk1): The invention provides a human SGK1 which is associated with cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, endocrinological... Agent: Banner & Witcoff, Ltd.
20090136935 - Dye compounds: The present disclosure provides compounds that may be used as chromogens, fluorochromes, or as both. Said compounds may further be used as substrate for at least one enzyme, wherein said enzyme is capable of processing an aromatic amine group (—NH2), an aromatic hydroxyl group (—OH), or an aromatic phosphate group... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090136932 - Fibers with isolated biomolecules and uses thereof: The present invention relates to compositions, methods, and uses for isolated biomolecule-containing fibers. The invention also relates to isolated, elongated biopolymers such as nucleic acids, polypeptides, lipids, and carbohydrates within fibers. The invention relates to methods of detecting and analyzing biomolecules in fibers using light, electrons, and neutrons. The invention... Agent: Wilson Sonsini Goodrich & Rosati
20090136954 - Genetic markers for scd or sca therapy selection: Variations in certain genomic sequences useful as genetic markers of Sudden Cardiac Death (“SCD”), or Sudden Cardiac Arrest (“SCA”) risk, are described. Novel genetic markers useful in assessing the risk of SCD, or SCA, and kits containing the same are provided herein. Methods of distinguishing patients having an increased susceptibility... Agent: Hahn & Voight-medtronic, Inc. Patent Applications
20090136925 - Identification of terpenoid-biosynthesis related regulatory protein-regulatory region associations: Materials and methods for identifying terpenoid regulatory region-regulatory protein associations are disclosed. Materials and methods for modulating expression of a sequence interest are also disclosed.... Agent: Fish & Richardson P.C.
20090136950 - Immunoglobulin display vectors: Disclosed are mammalian expression vectors for expressing simultaneous expression of immunoglobulins as both a secreted and cell surface bound form.... Agent: Pdl Biopharma, Inc. Attn: Legal Department
20090136936 - Immunoglobulin fc libraries: Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferentially bind to particular Fc receptors are described. Furthermore, the invention provides aglycosylated Fc domains that bind to Fc... Agent: Fulbright & Jaworski, L.L.P.
20090136952 - Manganese superoxide dismutase val16ala polymorphism predicts resistance to chemotherapeutic drug cancer therapy: The present invention provides, for the first time, the finding that the manganese superoxide dismutase Val16Ala polymorphism is significantly associated with prognosis for cancer patients treated with chemotherapeutic drug therapy. The alanine allele is a novel biomarker that predicts poor response and poor outcome to chemotherapeutic drug cancer therapy. Conversely,... Agent: Townsend And Townsend And Crew, LLP
20090136922 - Method for carrying out an electrochemical measurement on a liquid measuring sample in a measuring chamber that can be accessed by lines, and corresponding arrangement: Especially in order to carry out the so-called enzyme-coupled DNA hybridisation test in a closed cartridge including a microfluid system, using stored dry reagents, the reagents must be dissolved in the microfluid system and transported into the measuring chamber directly before the measurement. During the dissolution of the reagents in... Agent: Harness, Dickey & Pierce, P.L.C
20090136947 - Method for conducting an assay for neutralizing antibodies: A method for conducting a neutralization assay for the determination of the titer of antibodies in a sample is provided which is an improvement over existing neutralization assays because the sensitivity of the reporter gene assay to determine neutralization is increased by the use of a “one time use” cell... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090136933 - Method for determination of amount of double-stranded dna and kit for the determination: A method and kit for electrochemically simply determining with excellent precision the amount of double-stranded DNA does not require an expensive measurement electrode, such as an immobilized enzyme electrode or any high level electrode production technique which can retain uniform surface area accuracy. A method and kit are provided for... Agent: Fitch, Even, Tabin & Flannery
20090136930 - Method for the identification of microorganisms by means of in situ hybridization and flow cytometry: The invention relates to a combined method for specifically identifying microorganisms by means of in situ hybridization and flow cytometry. The inventive method is particularly characterized by an improved specificity and a shorter duration of the process as opposed to methods known in prior art.... Agent: Knobbe Martens Olson & Bear LLP
20090136943 - Method of detecting cancer using delta-catenin: The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from said subject, and then determining the presence or absence of delta-catenin in said sample,... Agent: Myers Bigel Sibley & Sajovec
20090136919 - Method to rapidly quantify mycobacteria in industrial fluids: The invention is a method for detecting and quantifying environmental mycobacteria in industrial fluids comprising extracting bacterial DNA from a sample of an industrial fluid; amplifying the extracted DNA; hybridizing an aliquot of the DNA to two or more amplification primers; and detecting the amplification product.... Agent: Arkema Inc. Patent Department - 26th Floor
20090136957 - Methods and compositions for regulating cell cycle progression via the mir-106b family: In one aspect, a method is provided of inhibiting proliferation of a mammalian cell comprising introducing into said cell an effective amount of at least one microRNA-specific inhibitor of at least one miR-106b family member. In another aspect a method is provided for accelerating proliferation of a mammalian cell comprising... Agent: Eileen S. Sun Merck & Co., Inc.
20090136960 - Methods and compositions for the identification of cancer markers: The present invention relates to methods and compositions for the identification of cancer markers. In particular, the present invention provides methods and compositions for the identification of glycosylated proteins and protein glycosylation patterns. The present invention further provides cancer markers identified using the described methods.... Agent: Casimir Jones, S.c.
20090136937 - Methods and systems for monitoring production of a target protein in a nanolipoprotein particle: Provided herein are methods and systems for the monitoring production of a target protein in of a nanolipoprotein particle (NLP) that also includes a scaffold protein and a membrane forming lipid. The target protein is capable of assuming an active form and an inactive form. Monitoring is performed by an... Agent: Llnl/steinfl & Bruno John H. Lee, Assistant Laboratory Counsel
20090136939 - Methods for diagnosis and therapy for pancreatic cancer and composition useful therein: Polynucleotide and polypeptide UKW are specific for pancreatic tumors. Diagnosis of UKW is therefore valuable for diagnosis of pancreatic tumors. Antibodies against UKW are, besides their value in diagnosis, useful as therapeutic agents for the treatment of pancreatic tumors.... Agent: Hoffmann-la Roche Inc. Patent Law Department
20090136938 - Methods for sequence-directed molecular breeding: The present invention provides breeding methods and compositions to enhance the germplasm of a plant by the use of direct nucleic acid sequence information. The methods describe the identification and accumulation of preferred nucleic acid sequences in the germplasm of a breeding population of plants.... Agent: Monsanto Company
20090136963 - Methods of concentrating an analyte: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090136941 - Methods, kits and compositions pertaining to linear beacons: This invention is directed to methods for determining amplified nucleic acid using Linear Beacons... Agent: Townsend And Townsend And Crew, LLP
20090136953 - Molecular diagnostic method for determining the resistance of a microorganism to an antibiotic: A sample (103) containing a microorganism is divided into a first sample portion (107) and a second sample portion (113), a growth medium i(109, 114) is added to both sample portions and an antibiotic (110) is combined with the second sample portion. The two portions are incubated and then molecular... Agent: Patton Boggs LLP
20090136948 - Nanoconfinement- based devices and methods of use thereof: The present invention provides a device/kit and methods of use thereof in rapid detection of target molecule binding to a cognate binding partner. The methods, inter-alia, make use of a device comprising channels or reservoirs, which are linked to nanochannels, whereby upon application of the cognate binding partner to the... Agent: Pearl Cohen Zedek Latzer, LLP
20090136961 - Novel compositions and methods for identification, assessment, prevention, and therapy of ovarian cancer: The present invention is directed to the identification of markers that can be used to determine whether ovarian cancer is sensitive or resistant to a therapeutic agent. In particular, the present invention is directed to the use of certain combinations of markers, wherein the expression of the markers correlates with... Agent: Millennium Pharmaceuticals, Inc.
20090136931 - Novel fluorescent labeling compound: A rare-earth fluorescent complex which forms a fluorescent complex with two or more rare-earth metals such as europium and terbium and can effectively be excited at a wavelength of 340 nm or longer; a fluorescent labeling agent comprising the rare-earth fluorescent complex; a method of fluorescent labeling in which the... Agent: Edwards Angell Palmer & Dodge LLP
20090136959 - Novel genes encoding proteins having prognostic, diagnostic preventive, therapeutic, and other uses: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the... Agent: Millennium Pharmaceuticals, Inc.
20090136929 - Novel in vitro method of quantifying demineralized bone osteoinductivity: The present invention provides an in vitro method for determining the osteoinductive potential of a biomaterial. In particular, the method measures the expression of osterix by osteoblast progenitor cells incubated with the biomaterial. In various embodiments, the biomaterial is demineralized bone (DMB) and the progenitor cells are incubated with DMB... Agent: Wood, Herron & Evans, LLP (zimmer)
20090136940 - Phosphoramidite nucleoside analogs: Described are phosphoramidite nucleoside analog monomers, precursors thereof, and oligonucleotides including one or more of the monomers. The monomers can be used during automated synthesis of oligonucleotide derivatives, and allow for incorporation of one or several reporter groups, organic molecules, bio-molecules, small molecules or other chemical groups at the internucleoside... Agent: Fish & Richardson PC
20090136923 - Primer composition for detecting mycobacterium sp. and the detection method: Disclosed are a primer composition including two pairs of primers targeting one gene (mpb64) concerning Mycobacterium sp., and a pair of primers targeting a human-derived gene (HLA-DR); and a method for detecting Mycobacterium sp. using a multiplex one-tube nested PCR method in which their primers are used to amplify two... Agent: Foley & Lardner LLP
20090136949 - Process for predicting the prognosis of squamous cell lung cancer: Disclosed in this specification is a method for predicting the prognosis of squamous cell lung cancer by observing regulatory changes in select miRNA sequences. These sequences may include hsa-mir-146b, hsa-mir-191, hsa-mir-206, hsa-mir-299-3p, hsa-mir-155, hsa-mir-15a, hsa-mir-122a, hsa-mir-513, hsa-mir-184, hsa-mir-511, hsa-mir-100, hsa-mir-10a, hsa-mir-453, hsa-mir-379, hsa-mir-202, hsa-mir-21, hsa-mir-126, hsa-mir-494, hsa-mir-432, hsa-mir-370, and combinations... Agent: Hiscock & Barclay, LLP
20090136955 - Protocols for making hepatocytes from embryonic stem cells: This disclosure provides a newly developed strategy and particular options for differentiating pluripotent stem cells into cells of the hepatocyte lineage. Many of the protocols are based on a strategy in which the cells are first differentiated into early germ layer cells, then into hepatocyte precursors, and then into mature... Agent: Geron Corporation Attn. David J. Earp
20090136918 - Quantification of microsphere suspension hybridization and uses thereof: A novel suspension hybridization assay was used to determine nucleic acid copy number by flow cytometry. The assay was validated with low copy (lc) products ranging in length from 100 to 2304 bp conjugated to spectrally-distinct polystyrene microspheres. In the example provided herein, these conjugated microspheres were used as multiplex... Agent: Erickson, Kernell, Derusseau & Kleypas, LLC
20090136951 - Quantification of nucleic acid molecules using multiplex pcr: Described are novel quantification methods and systems that permit, within the context of multiplex PCR, the quantification of all targets within a single reaction tube. The methods employ quantitation algorithms applied to the amplification profiles of internal calibration controls or standards utilizing a plurality of nucleic acid templates that are... Agent: Mark J. Fitzgerald
20090136927 - Random homozygous gene perturbation to enhance antibody production: The invention reflects enhanced antibody expression of an antibody of interest by cell lines transformed by random homozygous gene perturbation methods to either increase or decrease the expression pattern of a gene of the cell line other than the antibody of interest. The transformed cell line exhibits specific productivity rates,... Agent: Jagtiani + Guttag
20090136924 - Rapid generation of long synthetic centromeric tandem repeats for mammalian artificial chromosome formation: Methods are described for construction of long synthetic arrays of DNA repeats, such as alphoid repeats or other repeat sequences. The methods include concatamerization of DNA into short repeats (for instance using rolling circle amplification or directional in vitro ligation), followed by assembling the short repeats into long arrays by... Agent: Klarquist Sparkman, LLP
20090136934 - Targeting and tracing of antigens in living cells: The present invention relates to a method of detecting the presence, amount or subcellular location of an antigenic structure of interest in a cell, comprising the steps of: (a) (i) expressing a fusion protein directed to the antigenic structure of interest in said cell or (ii) introducing a fusion protein... Agent: Foley And Lardner LLP Suite 500
20090136966 - Normalization of complex analyte mixtures: The present invention relates to methods and compositions for the normalization of complex analyte mixtures. The invention allows the preparation of profiled samples from highly complex analyte mixtures, allowing the identification of relevant targets or biomarkers. The invention also relates to methods for producing devices, such as a support, suitable... Agent: Nixon & Vanderhye, PC
20090136964 - Novel anti-heparan sulfate antibody, method for detection of heparan sulfate, and kit for detection of heparan sulfate: An antibody which reacts with N-acetylheparosan and heparan sulfate that is derived from bovine kidney but does not substantially react with heparan sulfate derived from a murine Engelbreath-Holm-Swam tumor tissue, the antibody being produced with a hybridoma which is prepared using a substance composed of a protein and N-acetylheparosan bound... Agent: Knobbe Martens Olson & Bear LLP
20090136967 - Peptides for discrimination of prions: The aim of the present invention is to provide a non-intrusive way to isolate, concentrate and monitor the TSE disease-related pathogenic prion protein. The invention described several peptides and their ability to capture PrPSc from brain homogenate of prion disease infected animal and human. These eight peptides do not capture... Agent: Philip S. Johnson Johnson & Johnson
20090136965 - Use of antibody-ligand binding to characterise diseases: We have found that when an antibody binds to (captures) its specific ligand, the antibody-ligand complex is redirected to a route of elimination which is different from that which occurs naturally for the specific ligand that is not bound to an antibody. As a consequence, the amount of antibody-bound ligand... Agent: Novartis Corporate Intellectual Property
20090136968 - Novel in vitro methods for studying receptors recognizing volatile compounds: The present invention in particular relates to in vitro methods to identify and/or confirm the binding and/or function of a volatile compound onto a membrane-integrated receptor using volatile-compound-Binding Protein (BP) or compositions thereof. Additionally, the present invention relates to kits comprising receptor proteins recognizing volatile compounds or a candidate receptor... Agent: Edwards Angell Palmer & Dodge LLP
20090136970 - Nogo receptor homologues and their use: This invention relates to gene polypeptides and polynucleotides that encode proteins of the Nogo-66 receptor (NgR) family and are therefore called NgR homologue 1 (NgRH1). The invention further relates to their use in identifying compounds that may be agonists or antagonists that are potentially useful in regeneration and protection of... Agent: Novartis Corporate Intellectual Property
20090136969 - Lipoprotein associated phospholipase a2, inhibitors thereof and use of the same in diagnosis and therapy: The enzyme Lp-PLA2 in purified form, an isolated nucleic acid molecule encoding Lp-PLA2, the use of an inhibitor of the enzyme Lp-PLA2 in therapy and a method of screening compounds to identify those compounds which inhibit the enzyme.... Agent: Licata & Tyrrell P.C.
20090136972 - Methods for the diagnosis of genitourinary cancer: Methods for the diagnosis of genitourinary (GU) cancer are provided. In particular, urine has been found to contain significant levels of thromboxane receptor β (TPβ) methods for diagnosing GU cancer. Methods for assessing treatment, prognosing and staging GU cancers, as well as kits therefor, also are provided.... Agent: Fulbright & Jaworski L.L.P.
20090136971 - Multiplex liquid tissue method for increased proteomic coverage from histopathologically processed biological samples, tissues, and cells: The invention provides methods for multiplex analysis of biological samples of formalin-fixed tissue samples. The invention provides for a method to achieve a multiplexed, multi-staged plurality of Liquid Tissue preparations simultaneously from a single histopathologically processed biological sample, where the protocol for each Liquid Tissue preparation imparts a distinctive set... Agent: Proskauer Rose LLP
20090136973 - Determination of short-chain srl alcohol dehydrogenase (dhrs4) as a biomarker for inflammations and infections: The present invention relates to the use of short-chain SRL alcohol dehydrogenase (DHRS4, SEQ ID NO: 1) and peptides thereof as humoral biomarkers for the diagnostic detection and prognosis of the course, and also monitoring the course and therapy of septic inflammations and infections.... Agent: Heslin Rothenberg Farley & Mesiti PC
20090136975 - Non-desensitizing mutant of the transient receptor potential trpm5 ion channel: There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods, especially electrophysiological, suffer from a lack of sensitivity, rapid signal loss, low throughput, and are labor intensive. The claimed methods... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20090136978 - method for measuring phosphoric acid: In measuring phosphoric acid by the use of an enzyme cycling system using a dehydrogenase together with a thio-NADP, a thio-NAD, a reduced thio-NADP or a reduced thio-NAD as a coenzyme, phosphoric acid is measurable in a wide concentration range from a low concentration to a high concentration by measuring... Agent: Kratz, Quintos & Hanson, LLP
20090136976 - Luminescence-based composition: Luminescence-based compositions for measurement of aspartate aminotranserase, alanine aminotransferase, total-bilirubin, creatinine phosphokinase, or lactate dehydrogenase, wherein the chemiluminescence-based composition comprises 0.01-100 mM of luminol, 0.001-1000 U/mL of horseradish peroxidase (HRP), 0-10% of Triton X-100, 0-100 mM PIP, and 5˜500 mM of buffer at pH 6˜9, and the luminescence-base composition measures... Agent: Birch Stewart Kolasch & Birch
20090136977 - Novel targets for alzheimer's disease: Compositions and methods for post-translational modifications that include acetylCoA:lysine acetyltransferase activity in the ER lumen are provided. The disclosed compositions and methods are especially suited for the identification of compounds useful for the prevention or treatment of neurodegenerative diseases such as Alzheimer's.... Agent: Warf/bhgl
20090136979 - Class iia histone deacetylase (hdac) substrate: The present invention relates to the use of trifluoroacetylated lysine (Boc-L-Lys(ε- trifluoroacetyl)-MCA) as a substrate for histone deacetylases, specific for the class Ha subtype.... Agent: Merck And Co., Inc
20090136980 - Cd10-activated prodrug compounds: The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090136981 - Methods of measuring cell viability in tissue engineered products: This invention provides methods of measuring the viability of cultured cells by detecting one or more cell death-stable proteins or enzyme activities. Methods provided by the invention correlate viability to relative levels of enzyme activity in cell-containing and non-cell-containing fractions of a cell culture.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090136987 - Carbon nanotube based imaging agents: Compositions and methods related to carbon Nanotubes are provided. More particularly, imaging agents comprising carbon Nanotubes internally loaded with a contrast agent and associated methods are provided. One example of a method may involve a method for imaging comprising: providing an imaging agent comprising a carbon Nanotube loaded with contrast... Agent: Michelle M. Lecointe Baker Botts L.L.P.
20090136982 - Cell separation using microchannel having patterned posts: A micro now device (11, 71) for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts (23, 81). The posts are spaced across the width of an expanded collection chamber region (17,... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090136988 - Method and device to fractionate stem cells: A method and the relevant instrumentation to fractionate living, adherent stem cells, particularly of human origin, from different sources is disclosed, said method is based on the non-equilibrium, dynamic fractionation of cells assisted by the Earth gravity field.... Agent: Nixon & Vanderhye, PC
20090136984 - Method and means for enrichment removal and detection of listeria: The present invention relates to polypeptide fragments of endolysin Ply511, which recognise and bind listeria irrespective of the serotype but which have no cell wall hydrolysing enzymatic activity. The invention further relates to methods for enrichment, removal, and detection of listeria.... Agent: Fulbright & Jaworski L.L.P.
20090136989 - Method of measuring the activity of g(alpha)i-or g(alpha)o-coupled receptors using ca2+ influx in cells: A method of measuring the activation or deactivation of G(alpha)i- or G(alpha)o-coupled receptors, and methods of identifying agonists or antagonists of such receptors.... Agent: Crowell & Moring LLP Intellectual Property Group
20090136986 - Methods and cells for creating functional diversity and uses thereof: The invention provides methods and compositions relating to cells having altered functions, and the nucleic acids that impart those functions. Altered cellular function arises from in vivo directed recombination of genetic elements to yield a recombined nucleic acid. These methods and compositions may utilize altered host cells having altered recombination... Agent: Wolf Greenfield & Sacks, P.C.
20090136990 - Methods for identifying substances for the treatment of alzheimer's disease: The present invention relates to a method for diagnosing Alzheimer's disease and Parkinson's disease in a subject by analyzing the expression of Semaphorin 3 and downstream effectors. It also provides a method for identifying a substance useful in the prevention or treatment of Alzheimer's disease and Parkinson's disease, and a... Agent: Darby & Darby P.C.
20090136983 - Target sequences for synthetic molecules: The invention is based on the discovery that certain biarsenical molecules react with specified target sequences, thereby providing a facile means for labeling polypeptides containing the target sequence. The invention is useful in creating stable mammalian cell lines expressing a certain tetracysteine tagged polypeptides, thereby overcoming toxicity associated with native... Agent: Invitrogen Corporation C/o Intellevate
20090136985 - Vascular aging-predicting factor and utilization of the same: Abstract A predicting factor for vascular aging and an examination method for an early-stage lesion resulting from vascular aging are provided. Specifically, a predicting factor for vascular aging comprising a human apolipoprotein B100 having a glutathionylated thiol group; a method of examining a lesion resulting from vascular aging contain measurement... Agent: Wenderoth, Lind & Ponack, L.L.P.
20090136991 - Identifying naive, infected, or vaccinated mammals: This document provides methods and materials related to assessing a mammal's immunological state. For example, methods and materials related to assessing a mammal to determine whether the mammal is immunologically naïve with respect to a pathogen, was vaccinated against that pathogen, or is infected with that pathogen are provided. This... Agent: Fish & Richardson P.C.
20090136992 - Simplified tissue processing: Improved systems and methods for tissue processing are described here. The chemical process and the construction of the apparatus are simplified by using only two different solutions in two separate reaction modules. They are compatible with processing of tissue specimens for genetic analysis, histology, in situ antibody binding and hybridization,... Agent: Nixon & Vanderhye, PC
20090136993 - Process for the production of gamma-glutamylcysteine: The present invention relates to a process for preparing a compound comprising an α,γ amide linkage between a cysteine moiety and a glutamic acid moiety, such as γ-glutamylcysteine or a γ-glutamylcysteine derivative, the process comprising providing a cysteine derivative, a γ-glutamyl donor and an enzyme capable of transferring the γ-glutamyl... Agent: Jones Day
20090136999 - Compositions and methods for immunotherapy of cancer and infectious diseases: The present invention provides compositions and methods for the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases, for stimulating an immune response in a subject, and for use as an alternative to interleukin-12 (IL-12) treatment. In particular, the present invention provides Apicomplexa-related proteins (ARPs) that have... Agent: Wolf Greenfield & Sacks, P.C.
20090137000 - Dna polymerases and related methods: Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Agent: Townsend And Townsend And Crew, LLP
20090136998 - Luciferases and methods for making and using the same: Briefly described, embodiments of this disclosure include polynucleotides that encode mutant Cnidarian luciferases that exhibit modulated properties as compared to the corresponding wild-type luciferases, and the modulated properties include at least one of: modulated stability; enhanced light output; and modulated emission maximum. Embodiments of the present disclosure also include polypeptides... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP
20090136995 - Mutated prokaryotic cells with high secretion-levels: A mutated prokaryotic cell, which secretes higher amounts of at least one heterologous polypeptide of interest and which has a reduced expression-level of YusZ or YusX, or homologues thereof, when compared with an otherwise isogenic but non-mutated cell, and methods for constructing and using such a cell in the production... Agent: Novozymes North America, Inc.
20090136994 - Polypeptide having amidase activity and gene thereof: The present invention relates to a novel D-amidase isolated and purified from the Arthrobacter sp. KNK1101J, a gene encoding the above amidase, a recombinant plasmid comprising the above gene, and a transformant into which the above amidase gene has been introduced. In addition, the present invention also relates to a... Agent: Brinks Hofer Gilson & Lione
20090136997 - Pro1550 polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Genentech, Inc.
20090137005 - Il-12 for expression in mammalian cell: The present invention provides for nucleic acids improved for the expression of interleukin-12 (IL-12) in mammalian cells. The invention further provides for methods of expressing IL-12 in mammalian cells by transfecting the cell with a nucleic acid sequence encoding an improved IL-12 sequence.... Agent: Townsend And Townsend And Crew, LLP
20090137002 - Anti ephb4 antibodies and antibody fragments: The invention concerns antibodies and antibody fragments, specifically recognising the EphB4 receptor comprising heavy chains and light chain, comprising light and heavy CDR's, and their use as medicament for the treatment of pathological angiogenesis, in particular cancer therapy.... Agent: Millen, White, Zelano & Branigan, P.C.
20090137003 - Methods for recombinant manufacturing of anti-rsv antibodies: The invention relates to a method for manufacturing recombinant anti-RSV antibodies and antibody compositions. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing one distinct anti-RSV antibody. The cells... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20090137001 - Process for preparing recombinant human thrombin with culture cell: The present invention provides for a process for preparing a recombinant human thrombin. A process for preparing a recombinant human thrombin which comprises: (1) obtaining a transfectant cell producing a human prothrombin by introducing an expression vector, wherein a gene fragment coding for a human prothrombin gene is incorporated, into... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090137004 - Artificial entropic bristle domain sequences and their use in recombinant protein production: Compositions and methods for recombinant protein production and, more particularly, fusion polypeptides, polynucleotides encoding fusion polypeptides, expression vectors, kits, and related methods for recombinant protein production.... Agent: Seed Intellectual Property Law Group PLLC
20090137006 - Sugar kinases with expanded substrate specificity and their use: One preferred embodiment of the present invention provides a GalK variant comprising a Y371H, M173L or Y371H-M173L mutation for in vivo and in vitro glycorandomization. In another preferred embodiment, the E. coli GalK variant is mutated at one or more amino acids including R28, E34, D37, D174, Y223, C339, Y371,... Agent: Quarles & Brady LLP
20090137007 - Method for sequencing nucleic acid molecules: The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic acid polymerizing enzyme... Agent: Wilson Sonsini Goodrich & Rosati
20090137008 - Reduced inhibition of one-step rt-pcr: The present invention provides a method for amplifying a nucleic acid molecule. The method involves mixing an RNA template with a composition having a reverse transcriptase, a DNA polymerase and a RT inhibition reducer. The RT inhibition reducer can be Sso7d, Sac7d, Sac7e, Sso7e, AluI methylase, suramin, a phosphorothioate oligodeoxycytosine,... Agent: Townsend And Townsend And Crew, LLP
20090137009 - Method for producing hyaluronic acid: The method for manufacturing hyaluronic acid rich matrix comprises the steps of providing a crest; and decellularizing a tissue of crest to form a decellularized hyaluronic acid rich matrix.... Agent: Birch Stewart Kolasch & Birch
20090137010 - Method for producing amino acids using bacterium of the enterobacteriaceae family: A method for producing an L-amino acid is described, for example, L-phenylalanine and L-histidine, by fermentation using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified by attaching a DNA fragment able to be transcribed encoding the peptide represented in SEQ ID NO: 2, or a variant... Agent: Cermak & Kenealy LLP Acs LLC
20090137011 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the rcsa gene: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the rcsA gene.... Agent: Cermak & Kenealy LLP Acs LLC
20090137012 - Process for producing lactonase and utilitzation thereof: It has been required to economically produce a large amount of optically active γ-lactone derivatives (for example, pantolactone), which are useful as intermediates in synthesizing useful substances such as pharmaceutical drugs. To achieve this object, it is advantageous to employ an enzymatic technique of asymmetric hydrolysis with a hydrolyzing enzyme... Agent: Wenderoth, Lind & Ponack, L.L.P.
20090137013 - Microorganisms and methods for increased hydrogen production using diverse carbonaceous feedstock and highly absorptive materials: The disclosed invention relates to an isolated hydrogen gas producing microorganism, termed Enterobacter sp. SGT-T4™ and derivatives thereof. Compositions and methods comprising the disclosed microorganisms are also provided. The disclosed invention also relates to a method to increase the hydrogen production rate and yield of hydrogen gas producing microorganism in... Agent: Patentique PLLC
20090137015 - Method and apparatus for preparing material for microbiological fermentations: The present invention relates to a method for preparing organic material for microbiological fermentations of municipal waste water sludge for reducing the waste water sludge and/or of cellulosic material for the production of biofuels, with at least one of the following steps: disintegrating and/or liquefying the organic and/or cellulosic material... Agent: Baker & Hostetler LLP
20090137014 - Production of isoprenoids: Provided herein are methods for a robust production of isoprenoids via one or more biosynthetic pathways. Also provided herein are nucleic acids, enzymes, expression vectors, and genetically modified host cells for carrying out the subject methods. Also provided herein are fermentation methods for high productivity of isoprenoids from genetically modified... Agent: Jones Day
20090137016 - Process for rapid anaerobic digestion of biomass using microbes and the production of biofuels therefrom: A process for effecting anaerobic digestion of plant biomass, which entails the step of anaerobically digesting plant biomass with at least one species of rumen microorganisms.... Agent: The Nath Law Group
20090137017 - Generation and isolation of antigen-specific t cells: The present invention relates generally to methods for generating, expanding, and isolating antigen-specific T cells. Compositions of antigen-specific T cells activated and expanded by the methods herein are further provided.... Agent: Invitrogen Corporation C/o Intellevate
20090137018 - Magnetic three-dimensional cell culture apparatus and method: A culture apparatus and method for growing cells and tissue in a three-dimensional configuration harnesses magnetic, paramagnetic, ferromagnetic and diamagnetic forces. The cells or tissue are grown with magnetized core particles and are suspended via magnetic forces in a native, non-restricted, three-dimensional configuration while being maintained in a normal gravity... Agent: Smith Hopen, Pa
20090137020 - Method of reverse transcription: The present invention relates to reverse transcription of RNA, and in particular to reverse transcription by thermostable DNA polymerases. Thermoactinomyces vulgaris and Bacillus stearothermophilus possess reverse transcriptase activity in the presence of magnesium or manganese ions. Methods, compositions, and kits for reverse transcription and RT-PCR are also provided.... Agent: Casimir Jones, S.c.
20090137019 - Thermostable luciferases and methods of production: Luciferase enzymes with greatly increased thermostability, e.g., at least half lives of 2 hours at 50° C., cDNAs encoding the novel luciferases, and hosts transformed to express the luciferases, are disclosed. Methods of producing the luciferases include recursive mutagenesis. The luciferases are used in conventional methods, some employing kits.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.
20090137021 - Anti-inflammatory medicaments: Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.... Agent: Hovey Williams LLP
20090137022 - Extracting and purifying beta 1,4-xylanase: The invention relates to extracting and purifying an enzyme from a cell, particularly, but not exclusively, to extracting and purifying a β1,4-xylanase.... Agent: Ballard Spahr Andrews & Ingersoll, LLP
20090137023 - Cytoplasm of eukaryotic cells for reprogramming of somatic cells, healing, repairing and therapeutic applications: The present invention relates to a method for cellular reprogramming, healing and repairing for therapeutic applications by removal of the cytoplasm from the cell, collecting the cytoplasm together to form a bath of cytoplasm and then immersing one or more somatic cells into the cytoplasm bath. Alternatively, the collection of... Agent: Brandon Casutt
20090137024 - Method of separating target dna from mixed dna: The present invention relates to methods of separating target DNA from mixed DNA in a sample. In some embodiments, the target DNA may be viral DNA, bacterial DNA, fungal DNA or combinations thereof. In some embodiments the mixed DNA includes target DNA and non-target DNA.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090137025 - Apparatus for containing, cultivating, and harvesting photosynthetic marine microorganisms within water: An apparatus contains photosynthetic marine microorganisms within water, to permit the marine microorganisms to be cultivated and harvested. A self-supporting buoyant frame of the apparatus is to be placed within the water. A mesh lining of the apparatus is situated within the interior of the frame. The mesh lining is... Agent: Law Offices Of Michael Dryja
20090137026 - Cell culture device: In a culture vessel set in which one or plural recess portions are provided so that one or plural culture vessels can be contained in alignment, in view of space efficiency, m×n (row×column) pieces of culture vessels can be set in a matrix type. By using a pump, the culture... Agent: Stanley P. Fisher Reed Smith LLP
20090137027 - Solid phase methods for polynucleotide production: Polynucleotides having in excess of 1,000 nucleotides can be prepared using a solid phase synthesis technique. A feature of the technique is the use of a reusable solid support that contains covalently bound oligonucleotide. This covalently bound oligonucleotide is annealed to a bridge oligonucleotide, where the bridge is also annealed... Agent: Seed Intellectual Property Law Group PLLC
20090137028 - Embedded block humidifier, automatic thin slice manufacturing device, and automatic thin slice specimen manufacturing apparatus: An embedded block is capable of being humidified in a short time without influencing a surface temperature of the embedded block as much as possible. An embedded block humidifier for humidifying an embedded block having a biological specimen embedded in an embedding agent is provided which includes a vapor generating... Agent: Brinks Hofer Gilson & Lione
20090137029 - Multi-chambered receptacles: A receptacle having a plurality of interconnected chambers arranged to permit multiple process steps or processes to be performed independently or simultaneously. The receptacles are manufactured to separate liquid from dried reagents and to maintain the stability of the dried reagents. An immiscible liquid, such as an oil, is included... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090137030 - Incubator, schedule management method, and program: An input section of an incubator accepts, from a user, a first input selecting a specified incubation container which registers an observing schedule, and a second input specifying an imaging condition of the specified incubation container in an observing sequence. A calculating section calculates, according to the above-mentioned imaging condition,... Agent: Oliff & Berridge, PLC
20090137031 - Culturing apparatus and culturing method for photosynthesis microorganism: A culturing apparatus for photosynthesis microorganism provided by the present invention comprises a outer vessel, inner vessel, culture solution circulating portion and a heat transfer medium feeding portion. Culture solution containing photosynthesis microorganism is put into the outer vessel which is transparent and configured like a cylinder extending in a... Agent: Staas & Halsey LLP
20090137032 - Cell- and tissue culture device: The present invention relates to the field of cell and tissue culture. In particular, the invention provides a novel device for organotypic culture. The device comprises a medium conduit having one open end and one end closed by a porous membrane fused across it; and a frame holding the medium... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP
20090137034 - Methods for perfusion and plating of primary hepatocytes and a medium therefore: The present invention provides methods for culturing primary hepatocytes with improved long term function and improved viability, by plating the hepatocytes in the presence of an anti-oxidant(s) as well as an agent(s) which is a functional inhibitor of enzymes that generate reactive oxygen and reactive nitrogen species. One preferred embodiment... Agent: Ronald I. Eisenstein Nixon Peabody LLP
20090137033 - Novel fluorescent proteins from aequorea coerulscens and methods for using same: The present invention provides nucleic acid compositions encoding a novel colorless GFP-like protein, acGFP, from Aequorea coerulscens and fluorescent and non-fluorescent mutants and derivatives thereof, as well as peptides and proteins encoded by these nucleic acid compositions. The subject protein and nucleic acid compositions of the present invention are colored... Agent: B. Todd Patterson Moser, Patterson & Sheridan, LLP
20090137035 - Tweak receptor: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac... Agent: Immunex Corporation Law Department
20090137036 - Tweak receptor: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac... Agent: Immunex Corporation Law Department
20090137037 - Nucleic acids coding for humanized antibodies for binding sphingosine-1-phosphate: The present invention relates to anti-S1P agents, particularly humanized monoclonal antibodies (and antigen binding fragments thereof) specifically reactive with S1P, compositions containing such antibodies (or fragments), and the use of such antibodies (or fragments), for example, to treat diseases and conditions associated with aberrant levels of S1P.... Agent: Biotechnology Law Group 12707 High Bluff Drive
20090137040 - Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells: Activated human embryos produced by therapeutic cloning can give rise to human totipotent and pluripotent stem cells from which autologous cells for transplantation therapy are derived. The present invention provides methods for producing activated human embryos that can be used to generate totipotent and pluripotent stem cells from which autologous... Agent: Ropes & Gray LLP
20090137038 - Methods of proliferating stem cells: The invention relates to methods of proliferating stem cells. More particularly, the invention relates to the use of glycosaminoglycans or proteoglycans to promote the growth of stem cells in ex vivo culture, while preserving their multipotentiality.... Agent: Seed Intellectual Property Law Group PLLC
20090137039 - Targeting opposite strand replication intermediates of single-stranded viruses by rnai: The invention relates to methods and compositions for modulating viral replication through double-stranded RNA-mediated gene silencing (RNAi), wherein the antiviral methods and compositions preferentially target opposite strand replication intermediates of single-stranded RNA viruses.... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090137041 - 3-hydroxyisothiazole-4-carboxamidine derivatives as chk2 inhibitors: which are inhibitors of Chk2 and are useful as a radiation protection agents in anticancer radiotherapy. A method of modulating Chk2 in vitro includes treating a substrate with Chk2 in the presence of compounds of formula I. A method of making a compound of formula I includes: a) forming a... Agent: Mcdermott, Will & Emery
20090137042 - Processes and systems for hydrating and seeding medical implants with biological components: Methods and systems for providing an improved apparatus and packaging system to more expeditiously hydrate or reconstitute medical grafts and to effectively and uniformly seed the medical grafts with biological components and cultured cells. The systems generally comprise a container comprising entry port, at least one substrate cavity, and top,... Agent: Connolly Bove Lodge & Hutz LLP
20090137043 - Methods for modification of polymers, fibers and textile media: The present subject matter relates to the modification of fibers by the growth of films by the Atomic Layer Epitaxy (ALE) process, which is also commonly referred to as Atomic Layer Deposition (ALD). The presently disclosed subject matter relates in particular to a process for the modification of the surface... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20090137044 - Schistose microfibrillated article for cell growth: The present invention relates to culturing cells utilizing a matrix of microfibrillated thermoplastic polymeric materials. More specifically, the present invention relates to a method of culturing cells. In addition, the invention relates to a biaxially oriented microfibrillated article for culturing cells dispersed in a cell culture medium. The matrix of... Agent: 3m Innovative Properties Company
20090137045 - Pyridinium cationic lipids as gene transfer agents: Pyridinium cationic lipids useful as non-viral gene delivery agents are disclosed. The agents are prepared by reaction of pyrylium salts with primary amines. Also disclosed are methods of trasfectind cells using the pyridinium cationic lipids as gene transfer agents.... Agent: Howrey LLP-tamu C/oIPDocketing Dept.
20090137046 - Splicing-mediated regulation of gene expression: The present invention relates to methods and compositions for controlling the expression of a target gene, whereby an intron cassette such as INT9, an intronic mec-2-derived element, is incorporated into the target gene and expression of the product of the target gene is conditional upon functional expression of the RNA... Agent: Baker Botts L.L.P.05/21/2009 > patent applications in patent subcategories.
20090130646 - Blood collection device, method, and system for using the same: Disclosed is a fluid collection device wherein multiple, individual samples of fluid can be collected simultaneously. The device includes a chamber and an adapter which substantially and simultaneously distributes the blood to individual chambers with chamber specific additives. Also included is a system for using the blood collection device, preferably... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20090130647 - Method and apparatus for sorting particles: A method and an apparatus using acridine orange for sorting particles to precisely carry out the measurement of cells in the blood are provided. The cells in the blood is sorted by the steps of staining cells in the blood with acridine orange, irradiating light on the cells in the... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090130645 - Method for assessing the fibrinogen contribution in coagulation: The present invention is directed to a diagnostic method for the determination of a coagulopathy in a patient, in particular, for calculating the individual need of blood components, preferably blood platelets and/or fibrinogen and/or Factor XIII, which has to be substituted in a patient.... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20090130648 - Oxidized phospholipids: The invention relates to oxidized phospholipids having one of the general formulas (I) or (II) wherein A=O, C, NH, or S; B═O, C, NH, or S; and R2 is selected from the group consisting of —CO—(CH2)n—CH3; —CO—(CH2)b—CHO; and —CO—(CH2)n—COOH, with n=3-7, with the proviso that in general formula (I), R1... Agent: Workman Nydegger 1000 Eagle Gate Tower
20090130655 - Detection method using nanoaggregate-embedded beads and system thereof: The invention discloses a detection method using nanoaggregate-embedded beads and system thereof, which are characterized in that the nanoaggregate of Raman dye and metal nanoparticles is coated by an inorganic oxide to form a nanoaggregate-embedded bead, and which is then conjugated with a probe molecule to form a sensor bead.... Agent: Hudak, Shunk & Farine, Co., L.p.a.
20090130653 - Interference control panel for evaluation of analytical assays for samples derived from blood: The invention relates to quality control of analytical assays, particularly NAT assays of blood samples containing nucleic acids. A control panel containing quantified amounts of substances known to interfere with an analytical assay is used and compared with a reference sample in the analytical assay. A comparison of the assay... Agent: Orrick, Herrington & Sutcliffe, LLPIPProsecution Department
20090130654 - Method for screening hiv drug sensitivity: A method for monitoring ARV resistance, to determine viral fitness, and to forecast possible drug failure utilizes two nucleic acid sequences. One nucleic acid includes a retroviral nucleic acid devoid of at least a majority of the sequence for one of the two long terminal repeat regions. A second nucleic... Agent: Hahn Loeser & Parks, LLP
20090130649 - Methods for genotyping hvc: The present invention relates to methods for differentiating Hepatitis C virus (HCV) group A genotypes from HCV group B genotypes. The invention finds application in determining prognosis, and in the selection of treatment regimes, for patients infected with HCV.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090130650 - Methods for the production of highly sensitive and specific cell surface probes: A system and method for producing an oligonucleotide having a high affinity for extracellular or cell surface markers on a target cell. The resultant oligonucleotide probe can be used to detect a target biomolecule, in particular a cancer cell or infectious agent such as a bacterium, virus, or fungus, comprising... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090130652 - Optimization of west nile virus antibodies: The invention relates to the production of binding molecules. In particular, the invention relates to methods for producing binding molecules having an improved functionality of interest.... Agent: Traskbritt, P.C.
20090130651 - Variants of hepatitis b virus with resistance to anti-viral nucleoside agents and applications thereof: The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral... Agent: Knobbe Martens Olson & Bear LLP
20090130681 - 21132, a human g-protein coupled receptor family member and uses therefor: The invention provides isolated nucleic acids molecules, designated 21132 nucleic acid molecules, which encode novel GPCR family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 21132 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which... Agent: Millennium Pharmaceuticals, Inc.
20090130657 - Amplification blocker comprising intercalating nucleic acids (ina) containing intercalating pseudonucleotides (ipn): An amplification blocker comprising an intercalating nucleic acid (INA) containing two or more internal intercalating pseudonucleotides (IPNs) capable of blocking or reducing nucleic acid amplification. Use of the amplification blocker to block or reduce nucleic acid amplification.... Agent: Knobbe Martens Olson & Bear LLP
20090130658 - Arrangement for integrated and automated dna or protein analysis in a single-use cartridge, method for producing such a cartridge and operating method for dna or protein analysis using such a cartridge: A cartridge (card) having a system of microchannels and/or microcavities is used for automated DNA or protein analysis. In at least one embodiment, the microchannels or microcavities include geometrical structures for receiving dry reagents. For the purpose of industrial production, the cartridge is produced from a flat card support, e.g.,... Agent: Harness, Dickey & Pierce, P.L.C
20090130679 - Automated system and method for processing genetic material: The invention discloses an automated system and method for processing genetic material. Additionally, the automated system and method of the invention can extract a target genetic material from a sample; amplifying a target nucleic acid sequence from the genetic material; detecting the target nucleic acid by an optical detection module... Agent: Reed Smith LLP
20090130674 - Circular dna molecule having a conditional origin of replication, process for their preparation and their use in gene therapy: A prokaryotic recombinant host cell comprising a heterologous replication initiation protein that activates a conditional origin of replication and an extrachromosomal DNA molecule comprising a heterologous therapeutic gene and a conditional origin of replication whose functionality in the prokaryotic recombinant host cell requires a replication initiating protein which is foreign... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090130666 - Cytometric system including nucleic acid sequence amplification, and method: The invention relates to a cytometric system that can include a first station capable of selectively sorting a nucleic acid sequence-containing biological material from a biological sample, and a second station where nucleic acid of the sorted nucleic acid sequence-containing biological material, can undergo a nucleic acid amplification reaction. The... Agent: Kilyk & Bowersox, P.l.l.c.
20090130687 - Formulations and method isolating nucleic acids from arbitrary complex starting materials and subsequent complex genetic materials: The object of the invention is further a method for the isolation of nucleic acids, in particular of DNA, from arbitrary complex starting materials making use of the formulations according to the invention, characterised by lysis of the starting material, binding of the nucleic acids to a carrier material, washing... Agent: Buchanan Ingersoll & Rooney PC
20090130675 - Genes involved in the biosynthesis of thiocoraline and heterologous production of same: The invention relates to genes involved in the biosynthesis of thiocoraline and to the heterologous production of same. According to the invention, the cluster of genes responsible for the biosynthesis of thiocoraline was identified and cloned. Said cluster of genes can be used in the heterologous production of thiocoraline which... Agent: King & Spalding
20090130682 - Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, variant proteins... Agent: Celera Corporation
20090130663 - Hybridization detection method using an intercalator: To provide a novel and useful technique capable of achieving an improve S/N ratio in a hybridization detection technique using an intercalator. A method is provided wherein a hybridization is detected by measuring a fluorescence intensity from an intercalator I binding to a probe nucleic acid P and a complementary... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090130676 - Interaction trap systems for detecting protein interactions: Disclosed herein is a method of determining whether a first protein is capable of physically interacting with a second protein, involving: (a) providing a host cell which contains (i) a reporter gene operably linked to a protein binding site; (ii) a first fusion gene which expresses a first fusion protein,... Agent: Clark & Elbing LLP
20090130659 - Kits and methods for detecting methylated dna: The present invention relates to an in vitro method for detecting methylated DNA comprising (a) coating a container with a polypeptide capable of binding methylated DNA; (b) contacting said polypeptide with a sample comprising methylated and/or unmethylated DNA; and (c) detecting the binding of said polypeptide to methylated DNA. In... Agent: Foley And Lardner LLP Suite 500
20090130688 - Method for accessing microbial diversity: A method of interfering with quorum sensing regulation of genes to promote cell growth is disclosed. The method of is aimed at accessing microbial biodiversity. The method involves obtaining an environmental sample comprising at least one novel (uncultivated in the laboratory) microorganism, contacting the environmental sample with an effective amount... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20090130661 - Method for detecting il-16 activity and modulation of il-16 activity based on phosphorylated stat-6 proxy levels: Methods for detecting IL-16 biological activity, detecting modulation of IL-16 biological activity, and diagnosing the presence of, or susceptibility to, an IL-16-related disorder in a subject involve measuring and comparing the levels of a phosphorylated STAT-6 proxy produced by eukaryotic cells expressing CD4 or CD9, peripheral blood mononuclear cells, HuT-78... Agent: Philip S. Johnson Johnson & Johnson
20090130662 - Method for diagnosis of prostate cancer: The present invention provides a method for detecting and/or quantifying PCA-1 in a body fluid sample from a subject as a prostate cancer marker. The present invention also provides a method for detecting and/or quantifying an anti-PCA-1 autoantibody in a body fluid sample from a subject as a prostate cancer... Agent: Foley And Lardner LLP Suite 500
20090130677 - Method for isothermal amplification of nucleic acids and method for detecting nucleic acids using simultaneous isothermal amplification of nucleic acids and signal probe: The present invention relates to a method for isothermal amplification of nucleic acids and a method for detecting nucleic acids, which comprises characterized in simultaneous isothermal amplification of nucleic acids and a signal probe to a method for isothermal amplification of target nucleic acids using an external primer set and... Agent: Ipla P.A.
20090130686 - Method for the microscopic localization of a selected, intracellular dna segment with a known nucleotide sequence: The method for the microscopic localization in situ of a selected intracellular native genome segment with a known nucleotide sequence is characterized by the nature and the sequence of the following measures: (1.) The target DNA is analyzed, via genome databases, for partial sequences which constitute a unique pattern within... Agent: Joyce Von Natzmer Pequignot + Myers LLC
20090130664 - Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance in pseudomonas aeruginosa: The “instant evolution” system was initially developed in E. coli, primarily because of the ease with which this organism can be genetically manipulated. Because many of the functionally important regions of rRNA are conserved among bacteria, drug leads developed against conserved targets in the E. coli system may produce broad-spectrum... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20090130678 - Methods and kits for breast cancer prognosis: The present invention relates to the field of prognosis of a proliferative disease in a patient. More specifically, the present invention relates to methods for the identification of the likely outcome of breast cancer in a breast cancer patient. The invention also relates to methods for the identification of the... Agent: Siemens Corporation Intellectual Property Department
20090130673 - Methods for detecting and differentiating mycobacterium genus and mycobacterium avium complex in a sample or culture: The present invention relates to compositions and methods for detecting Mycobacterium genus (Mycobacterium sp.) bacteria (e.g., M. tuberculosis) and M. avium complex (MAC; M. avium, M. scrofulaceum and M. intracellulaire) in a clinical sample or culture. The present invention also relates to differentiating cultures or samples comprising (Mycobacterium sp.) bacteria... Agent: Kevin Farrell Pierce Atwood
20090130672 - Methods for identifying novel pesticidal gene homologues: Methods and compositions for identifying novel pesticidal gene homologues are provided. Specifically, the methods of the invention comprise systematically designing oligonucleotide primers that are specific for a pesticidal gene of interest and performing successive rounds of PCR amplification of nucleic acid material from a microorganism, particularly a Bacillus thuringiensis strain,... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.
20090130684 - Methods of detecting and treatment of cancers using scutellaria barbata extract: An extract of Scutellaria Barbata D. Don is effective in the arrest of cancer cell growth. The extract of Scutellaria Barbata D. Don may be used as a therapeutic treatment for patients who have been identified as having cancer. In some situations, a patient is identified as having a type... Agent: Wilson Sonsini Goodrich & Rosati
20090130656 - Neisseria gonorrhoeae detection: A method for determining whether a human individual is or has been infected with Neisseria gonorrhoeae, is provided. The method detects a Neisseria gonorrhoeae, porA nucleic acid fragment obtained from a biological sample. The method includes subjecting the biological sample to nucleic acid sequence amplification using primers having respective nucleotide... Agent: Proskauer Rose LLP
20090130685 - Plants with altered root architecture, related constructs and methods involving genes encoding leucine rich repeat kinase (llrk) polypeptides and homologs thereof: Isolated polynucleotides and polypeptides and recombinant DNA constructs particularly useful for altering root structure of plants, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter functional in a plant,... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090130665 - Polymer compositions and uses thereof: Block copolymers labelled with molecular recognition units and comprising a hydrophobic block and a luminescent block are presented. A method of detecting biomolecules using such block copolymers is also presented. More specifically, the block copolymers of the present invention have the following Formula (I): wherein “A” is a hydrophobic block;... Agent: Fulbright & Jaworski L.L.P.
20090130683 - Predicting and diagnosing patients with autoimmune disease: The present invention provides methods for the prediction and diagnosis of autoimmune diseases, including Systemic Lupus Erythematosus, using single nucleotide polymorphism in TNFAIP3 (A20).... Agent: Fulbright & Jaworski L.L.P.
20090130667 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 81 to 83 and complementary or modified sequences thereof or a... Agent: Fitzpatrick Cella Harper & Scinto
20090130668 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 78 to 80 and complementary or modified sequences thereof or a... Agent: Fitzpatrick Cella Harper & Scinto
20090130669 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 92 to 93 and complementary or modified sequences thereof or a... Agent: Fitzpatrick Cella Harper & Scinto
20090130670 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequence of SEQ ID NO. 94 and complementary or modified sequences thereof or a combination of... Agent: Fitzpatrick Cella Harper & Scinto
20090130671 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 73 to 75 and complementary or modified sequences thereof or a... Agent: Fitzpatrick Cella Harper & Scinto
20090130660 - Single nucelotide polymorphism (snp): Association of Type 2 diabetes with single nucleotide polymorphisms and haplotypes are disclosed. Also disclosed are diagnostic applications in identifying those who have Type 2 diabetes or are at risk of developing Type 2 diabetes, and discovery of therapeutic agents and methods of treatment.... Agent: Hoffmann-la Roche Inc. Patent Law Department
20090130680 - Solid support: The present invention provides a solid support for performing steps of isolation of cell or extraction and purification of nucleic acid, safely, easily, efficiently, and with high yield in the genetic test for investigating the presence of pathogenic bacterial infection. A solid support for binding with cell as an embodiment... Agent: Lucas & Mercanti, LLP
20090130690 - Method for the diagnosis of rheumatoid arthritis: The present invention relates to a novel diagnostic marker useful for the diagnosis of rheumatoid arthritis comprising the autoantibodies of mannose binding lectin protein and a process thereof.... Agent: Meyertons, Hood, Kivlin, Kowert & Goetzel, P.C.
20090130689 - Method useful for detecting encephalopathies: The invention concerns a method of detecting a TSSE Disease or prion disease. The invention further concerns a method for amplifying oligomerization of isoforms of the cellular prion PrPSc.... Agent: Oliff & Berridge, PLC
20090130691 - Screening proteinase modulators using a chimeric protein and ski-i proprotein convertase substrates and inhibitors: A chimeric protein comprising in sequence a signal peptide, a first amino acid tag, a proteinase bait, a second amino acid tag, a transmembrane domain and a cytosolic domain, wherein the cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes. A cell... Agent: Goudreau Gage Dubuc
20090130692 - Use of microproteins as tryptase: Disclosed are uses of microproteins preferably microproteins forming a cystine knot (i.e. belonging to the family of inhibitor cystine knot (ICK) polypeptides) or polynucleotides encoding said microproteins for the preparation of a pharmaceutical composition for treating or preventing a disease that can be treated or prevented by inhibiting the activity... Agent: Arent Fox LLP
20090130695 - Gef-h1b: biomarkers, complexes, assays and therapeutic uses thereof: The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.... Agent: Pfizer Inc
20090130694 - Mac-2bp as a marker for the diagnosis of gastric cancer: Disclosed is a diagnostic kit for gastric cancer. It comprises an agent capable of detecting and quantitatively assaying the gastric cancer marker Mac-2BP (Mac-2 binding protein). Also, a method for detecting the gastric cancer marker using the kit is disclosed.... Agent: Ohlandt, Greeley, Ruggiero & Perle, LLP
20090130693 - Novel biomarkers for diagnosis and/or prognosis of neoplasias in animals: The invention is generally applicable in the field of biomedical engineering, and specifically relates to a method for diagnosis and/or prognosis of neoplasias in animals. The invention further relates to a diagnostic/prognostic kit associated to such method, a reagent for the preparation of such kit and the use of particular... Agent: Greenberg Traurig LLP (la)
20090130696 - Hdl cholesterol sensor using selective surfactant: A method for the determination of the amount of cholesterol in high density lipoproteins in a high density lipoprotein containing sample, said method comprising reacting the sample with a surfactant which preferentially reacts with high density lipoproteins in the sample, said surfactant being selected from hydroxyethyl glucamide derivatives and N-acyl-N-methyl... Agent: Quarles & Brady LLP
20090130697 - Biological systems input-output response system and plant sentinels: A eukaryotic input circuit: computationally designed receptors, synthetic eukaryotic signal transduction pathways, and a synthetic signal sensitive promoter that allow highly specific transcriptional induction in response to an externally provided ligand is disclosed. The input circuit is able to specifically bind a targeted substance and transmit a signal to the... Agent: Jondle & Associates P.C.
20090130698 - Customizable and renewable nanostructured interface for bioelectronic applications: A chemical composite useful for preparing a bioelectronic device includes a biologically active compound, such as an enzyme, that is bound directly or indirectly to a polyelectrolye, which can be reversibly coupled to a chemically treated electrically conductive substrate by electrostatic forces to provide biomimetic sensors, catalyst systems, and other... Agent: Price Heneveld Cooper Dewitt & Litton, LLP
20090130700 - Device and method for determining the concentration of a substance: The invention provides a method for determining a concentration of a substance in a compartment comprising exciting an endogenous compound, or a functional part, derivative, analogue or precursor thereof, measuring the lifetime of the luminescence and/or transient absorption exhibited by said compound, functional part, derivative, analogue and/or precursor, and correlating... Agent: Traskbritt, P.C.
20090130699 - Method for testing substances on biomatrices: The invention relates to a method for testing one or several substances. According to said method, a tissue equivalent is cultivated, the substance/s is/are made to affect the tissue equivalent, and it is determined whether the effect of the substance/s has resulted in a modification of the tissue equivalent and/or... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090130702 - Methods and systems for providing a nutraceutical program specific to an individual animal: The present invention relates to methods and systems for providing an animal with a nutraceutical program that is specifically tailored to address the deficiencies and/or needs of the particular animal. Blood is drawn from the animal and analyzed at a lab to obtain blood test results. The blood test results... Agent: Lipsitz & Mcallister, LLC
20090130703 - Methods of detection of changes in cells: Methods are provided to detect changes in cells without the use of detection labels.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090130701 - Novel sequence variants of multi-drug resistance genes, mdr1 and mrp1, and recombinant cells expressing mrp1 and mdr1 for assessment of drug penetration and disposition: Provided are compositions relating to novel MDR1 polymorphisms, including nucleic acids, polypeptides, and recombinant cells, as well as methods for detection of MDR1 polymorphisms in biological samples and elucidation of the influence of MDR1 polymorphisms on MDR1 protein function. Also provided are a rat MRP1 cDNA and protein, stable cell... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20090130707 - Methods of reducing the inhibitory effect of a redox active metal ion on the enzymatic hydrolysis of cellulosic material: The present invention relates to methods of producing a cellulosic material reduced in a redox active metal cation having a redox potential (Eo) in the range of about −0.4 to about 1.2 volts, comprising treating the cellulosic material with an effective amount of a chelator to reduce the inhibitory effect... Agent: Novozymes, Inc.
20090130705 - Nadp-dependent glucose dehydrogenase from gluconobacter oxydans: The present invention relates to microorganisms genetically engineered to increase yield and/or efficiency of biomass production from a carbon source, such as e.g. glucose. Processes for generating such microorganisms are also provided by the present invention. The invention also relates to polynucleotide sequences comprising genes that encode proteins that are... Agent: Nixon & Vanderhye, PC
20090130704 - Novel bioreactor: This invention provides bioreactors having a selectively permeable porous material with an open pore structure, useful for producing products including hydrogen gas, biomass, chemicals, and pharmaceuticals. The porous materials are utilized, for example, as one or more portions of or entire walls, covers, floors, filters, windows, or tubes of the... Agent: Greenlee Winner And Sullivan P C
20090130706 - Photobioreactor systems positioned on bodies of water: Certain embodiments and aspects of the present invention relate to a photobioreactor including photobioreactor units through which a liquid medium stream and a gas stream flow. The photobioreactor units are floated on a body of water such as a pond or a lake. The liquid medium comprises at least one... Agent: Wolf Greenfield & Sacks, P.C.
20090130708 - Dipeptide crystals and process for production thereof: The present invention provides: (1) crystals of a dipeptide which do not substantially comprise a dipeptide comprising D-amino acid as a constituent or a polypeptide consisting of three or more amino acids; and (2) crystals of a dipeptide which do not substantially comprise a dipeptide comprising D-amino acid as a... Agent: Fitzpatrick Cella Harper & Scinto
20090130709 - Endomannosidases in the modification of glycoproteins in eukaryotes: The present invention generally relates to methods of modifying the glycosylation structures of recombinant proteins expressed in fungi or other lower eukaryotes, to more closely resemble the glycosylation of proteins from higher mammals, in particular humans. The present invention also relates to novel enzymes and, nucleic acids encoding them and,... Agent: Merck And Co., Inc
20090130715 - Antibodies to cd40: The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies... Agent: Ropes & Gray LLP
20090130712 - Compositions and methods of producing hybrid antigen binding molecules and uses thereof: This disclosure relates to hybrid antigen binding molecules including at least two polypeptide chains, with at least one polypeptide chain comprises an antigen binding moiety linked to an amino acid sequence of a subunit of a heterodimeric proteinaceous hormone. Also disclosed are methods of making and using such hybrid antigen... Agent: Emd Serono Research Institute
20090130710 - Enhancing vegetative protein production in transgenic plants using seed specific promoters: In various embodiments, the invention provides expression systems for heterologous protein expression in vegetative plant tissues, utilizing plant seed gene components that are adapted to orchestrate high levels of vegetative protein production. The expression systems may include host plant cells having recombinant genomes, and the plant cells may be maintained... Agent: Bozicevic, Field & Francis LLP
20090130714 - Process for purifying recombinanat tissue plasminogen activator (tpa): The present invention relates to an efficient and improved process for purifying a recombinant protein. The invention relates to the purification of tissue plasminogen activator (tPA), such as truncated human tPA, recombinantly produced in bacteria, for example in E. coli. The present invention provides a process that requires less refolding... Agent: Foley And Lardner LLP Suite 500
20090130711 - Recombinant vector capable of increasing secretion of koji mold protease: To improve the activity of a Koji mold protease in a solid or liquid culture medium in the production of foods (e.g., a seasoning), pharmaceuticals (e.g., a digestive agent), protease for use in a detergent and the like. Disclosed are a recombinant vector having capability of increasing the secretion of... Agent: Birch Stewart Kolasch & Birch
20090130713 - Trichoderma promoter: A promoter for use in producing proteins in filamentous fungal host cells is provided. In one embodiment, the promoter comprises SEQ ID NO:1, or a variant or a truncated form thereof that has promoter activity in a host cell. Also provided are recombinant nucleic acids, vectors containing the promoter and... Agent: Lynn Marcus-wyner, Ph.d. Danisco Us, Inc., Genencor Division
20090130716 - Rationally designed antibodies: Antibodies or fragments thereof having at least two CDR regions replaced or fused with biologically active peptides are described. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities.... Agent: Ropes & Gray LLP
20090130717 - Novel k04-0144 substance and a process for production thereof: A microorganism represented by a strain K04-0144 belonging to Streptomyces sp. having ability to produce K04-0144 substance is cultured in the medium, and the isolated K04-0144A substance, K04-0144B substance and K04-0144C substance therefrom have strong antibacterial activities against Gram-positive bacteria including methicillin-resistant Streptococcus aureus (MRSA), consequently these are useful as... Agent: Birch Stewart Kolasch & Birch
20090130718 - Gene site saturation mutagenesis: A method for producing progeny polynucleotides and polypeptides by Gene Site Saturation Mutagenesis (GSSM). The method provides a set of degenerate primers corresponding to codons of a template polynucleotide, and performs polymerase elongation to produce progeny polynucleotides, which contain sequences corresponding to the degenerate primers. The progeny polynucleotides can be... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090130720 - Methods and kits for reducing non-specific nucleic acid amplification: Methods and kits for efficient amplification of nucleic acids are provided. The methods comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having terminal mismatch primer-dimer structure. The methods also comprise in-vitro amplification of a nucleic acid template employing partially constrained primers having nucleotide analogues. The methods... Agent: General Electric Company Global Research
20090130719 - Microfluidic cartridge: The technology described herein generally relates to microfluidic cartridges configured to amplify and detect polynucleotides extracted from multiple biological samples in parallel. The technology includes a microfluidic substrate, comprising: a plurality of sample lanes, wherein each of the plurality of sample lanes comprises a microfluidic network having, in fluid communication... Agent: Fish & Richardson P.C.
20090130721 - Improved nucleic acid amplification procedure: The invention provides methods for amplification of polynucleotide sequences using primers containing single-stranded RNA. The methods employ use of an enzyme capable of cleaving single-stranded RNA, such as RNase I, to degrade a first RNA-containing primer prior to addition of a second RNA-containing primer. The invention also provides compositions and... Agent: Wilson Sonsini Goodrich & Rosati
20090130722 - Thermally-tolerant pectin methylesterase: Enzymes accumulated in plant cell walls serve diverse physiological functions including metabolism, polysaccharide structure modification, and molecular communication in interactions with other organisms. Pectin methylesterases are economically important enzymes for their impact on quality and processing properties of fruit and vegetable food products. We have now purified TT-PME to homogeneity... Agent: Usda, Ars, Ott
20090130723 - Methods for purifying amino acids: In the method for separating and purifying histidine from a culture containing the amino acid, the culture containing histidine and microbial cells is charged onto the top of a column filled with a carrier particle whose particle size is 350 μm or more and which has an ability to adsorb... Agent: King & Spalding
20090130724 - Enzymatic demethylation of flavonoids: The invention discloses the demethylation of 5-methoxyflavonoids by bacterial enzymes, the use of these enzymes in the production of phytoestrogens in vitro, and in pharmaceutical compositions in combination with a source of methylated 5-methoxyprenylflavonoids.... Agent: Clark & Elbing LLP
20090130725 - Gene sms 14: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, PC
20090130726 - Process for converting aromatic halo-substituted dinitriles into halo-substituted cyanocarboxylic acids: The present invention is directed to a process for converting aromatic halo-substituted dinitriles into the corresponding cyanocarboxylic acids in the presence of a nitrilase.... Agent: Birch, Stewart, Kolasch & Birch, LLP
20090130727 - Method of expressing long-chain prenyl diphosphate synthase: The present invention provides a method of producing a long-chain prenyl diphosphate synthase (in particular decaprenyl diphosphate synthase and solanesyl diphosphate synthase) using a gene and a protein which are required for enabling or enhancing the activity expression of a eukaryote-derived long-chain prenyl diphosphate synthase as well as a method... Agent: Brinks Hofer Gilson & Lione
20090130728 - Process for producing a triglyceride: A process for the production of a composition comprising 1,3-dioleyl-2-palmitoyl glyceride (OPO) comprises subjecting a palm oil stearin, with an iodine value (IV) between about 2 and about 12 to enzymic transesterification, with oleic acid or a non-glyceride ester thereof.... Agent: Morgan Lewis & Bockius LLP
20090130729 - Biocatalytic manufacturing of (meth) acrylic esters: The invention relates to a biocatalytic method or process for the synthesis of esters of acrylic acid and/or methacrylic acid free of positively chargeable/charged groups, comprising reacting one or more alcohols (alcohol starting materials) which are free of positively chargeable or charged groups with (meth)acrylyl-CoA, preferably in the presence of... Agent: Joann Villamizar Ciba Corporation/patent Department
20090130730 - Yeast for extraction of lipid-soluble component, method for producing the same, color-improving agent using the same and method for producing lipid-soluble component: The production process for yeast for fat-soluble component extraction according to the invention comprises a breeding step wherein yeast having fat-soluble components to be extracted are bred, in such a manner that the pH of the medium decreases as growth proceeds, until falling below the limit of the breedable pH... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090130732 - Conversion of heavy oil and bitumen to methane by chemical oxidation and bioconversion: A process for the conversion of heavy oil or bitumen to methane by chemical oxidation and bioconversion.... Agent: Fulbright & Jaworski, LLP
20090130733 - Method for producing non-infectious products from infectious organic waste material: A method for producing a hydrolyzed, sterile, denatured product from infectious organic waste material includes (a) introducing, into a reactor capable of being heated and pressurized, infectious organic waste material to form a reaction mixture; (b) subjecting the reaction mixture to saturated steam at a temperature and pressure within the... Agent: Panitch Schwarze Belisario & Nadel LLP
20090130731 - Microorganism capable of accumulating ultra high molecular weight polyester: An object of the present invention is to provide a microorganism strain capable of accumulating P(3HB-co-3HH) having an ultra high molecular weight at a high level, and to provide a method of producing a safe and inexpensive copolymerized polyester using the same. The present invention is related to a microorganism... Agent: Sughrue Mion, PLLC
20090130734 - System for the production of methane from co2: A method of converting CO2 gas produced during industrial processes comprising contacting methanogenic archaea with the CO2 gas under suitable conditions to produce methane.... Agent: Michael Best & Friedrich LLP
20090130735 - Static support bed for purification, separation, detection, modification and/or immobilization of target entities and method of using thereof: The subject matter hereof discloses a static support bed (SSB) for purification, separation, modification, and/or immobilization of target chemical entities or target biological entities present in a fluid. The static support bed hereof may include one or more microwire supports suitable for the attachment of target chemical entities or target... Agent: Berenbaum, Weinshienk & Eason, P.c
20090130736 - Pretreatment method for extraction of nucleic acid from biological samples and kits therefor: The present invention relates to methods for pretreating biological samples for extraction of nucleic acid therefrom. The present invention employs a combination of at least one protein denaturant with one or more of the following elements to form a reaction mixture for extraction of nucleic acid: (1) at least one... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20090130737 - Novel fungal proteins and nucleic acids encoding same: Disclosed herein are fungal nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The novel leucine aminopeptidase (LAP) and other amino- and carboxypeptidases polypeptides, referred to herein... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090130738 - Media for membrane ion exchange chromatography: Media for chromatographic applications, wherein the media is a membrane having a surface coated with a polymer such as a polyethyleneimine. The immobilized polymer coating is modified with a charge-modifying agent to impart quaternary ammonium functionality to the media. The media is well suited for chromatographic purification of virus.... Agent: Nields, Lemack & Frame, LLC
20090130739 - Deactivation of mineral encapsulated nanobacteria: Compositions and methods for deactivating articles contaminated with nanobacteria, generally comprise a dispersant and/or a dissolution agent, and a deactivator. The methods and compositions of the invention are advantageously utilized to decontaminate and/or sterilize various articles such as medical and manufacturing devices or surfaces.... Agent: Hudak, Shunk & Farine, Co., L.p.a.
20090130740 - Automated biological growth and dispensing system: An automated biological growth and dispensing system utilizing a modular growing tank which is removable for replacement by another growing tank. Mechanisms for the delivery of air, water and/or nutrients are adapted to permit the growing tank to be readily coupled and uncoupled for easy and inexpensive replacement. Mechanisms for... Agent: Riches, Mckenzie & Herbert, LLP
20090130741 - De novo synthesized plasmid, methods of making and use thereof: The invention relates to a de novo synthesized plasmid. The plasmid comprises relevant sequences for plasmid replication and plasmid selection. The methods of making and use of the plasmid are disclosed. The plasmid can be used to make other plasmids. These plasmids and their host cells can be used for... Agent: Chuan Li
20090130742 - Vessel and system for biological regeneration of ion exchange and absorptive media: A system and method for biological regeneration of ion exchange and absorptive media including a vessel configured to contain a bed of contaminated media particles. The vessel includes a first region configured to receive biological regenerating fluid for contacting media particles in the first region at a first volumetric flowrate... Agent: Ratnerprestia
20090130743 - Vibration type microinjection device: A vibration type microinjection device comprises a vibrator (28) which is connected in series with a micropipette (8) and which has a piezoelectric actuator (29) installed in a housing, and a signal control device (21) for controlling an electric signal applied to the piezoelectric actuator (29), wherein vibration is applied... Agent: Bacon & Thomas, PLLC
20090130744 - Apparatus and method to measure platelet contractility: An apparatus and method for measuring blood platelet contractility, hereinafter called a “retractometer” is disclosed. Also disclosed is a system apparatus and method for automatically measuring platelet contractility in a plurality of samples, having an array of retractometer units and an electronic solenoid valve controller to fully automate screening in... Agent: Fuess & Davidenas
20090130745 - Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples: The technology described herein generally relates to systems for extracting polynucleotides from multiple samples, particularly from biological samples, and additionally to systems that subsequently amplify and detect the extracted polynucleotides. The technology more particularly relates to microfluidic systems that carry out PCR on multiple samples of nucleotides of interest within... Agent: Fish & Richardson P.C.
20090130746 - Microchannel surface coating: The present invention relates to a method for improving the efficiency of biochemical reactions in channels of microfluidic devices. More specifically, the present invention relates to the use of chitosan or a chitosan derivative for coating channel surfaces to reduce non-specific adsorption of reagents to microfluidic channels. This reduction of... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090130747 - System and method of enhancing production of algae: The present invention relates to a system and method of enhancing production algae, comprising a container containing liquid, algae and plates made from a kind of material for absorbing and scattering light. The shape, dimension and arrangement of the plates are optimized.... Agent: Wpat, PC Intellectual Property Attorneys
20090130748 - Optoreactor: The invention relates to a bioreactor for the treatment of industrial or domestic effluent, comprising a container and a packing, wherein a potential difference forms between the packing and the container, which is provided with a device which prevents corrosion of the container as a result of the potential reversal... Agent: Boyle Fredrickson S.c.
20090130749 - Temperature-controlled incubator having rotatable door: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090130750 - Specimen culturing assembly suitable for use in in-vitro fertilization and in other cell culturing procedures: An assembly is disclosed that is to be used for the culturing of specimens such as embryos and gametes for use in in vitro fertilization. The assembly includes an annular ring which is affixed to the stage of an optical viewing instrument, such as a microscope. The viewing instrument is... Agent: William W. Jones
20090130752 - Biodegradable poly(disulfide amine)s for gene delivery: Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(CBA-DAE), poly(CBA-DAB), and poly(CBA-DAH). These compositions are made by Michael addition between N,N′-cystaminebisacrylamide and N-Boc-protected diamine monomers, followed by N-Boc deprotection. Complexes are formed by mixing the poly(disulfide amine)s with nucleic acid.... Agent: Alan J. Howarth
20090130751 - Reduction of off-target rna interference toxicity: The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.... Agent: Viksnins Harris & Padys Pllp
20090130753 - Method for obtaining and storing multipotent stem cells: An isolated tissue is provided comprising a source of millions of postnatal stem cells expressing embryonic stem cell markers. A method is also provided for storing or banking such isolated tissue to provide stems cells for later therapeutic use for the donor or for allogenic transplant with donor permission.... Agent: Maginot, Moore & Beck, LLP Chase Tower
20090130754 - Method for culturing human embryonic stem cells: The present invention relates to a method for culturing human embryonic stem cells (hESCs) in a hESC culture medium comprising a porous membrane, feeder cells being attached to a bottom of the porous membrane and a method for recovering human embryonic stem cells using the same.... Agent: The Nath Law Group
20090130756 - Cryopreservation of cells using cross-linked bioactive hydrogel matrix particles: The present invention is directed to methods of cryopreserving cells and cryopreserved cells prepared according to the methods. In specific embodiments, the method comprises combining cells with a cross-linked hydrogel matrix in particulate form, the matrix comprising a polyglycan cross-linked to a polypeptide and subjecting the combination to cryopreservation conditions.... Agent: Alston & Bird LLP
20090130755 - Hydrogel networks having living cells encapsulated therein: The present invention is directed to a hydrogel network comprised of a physically cross-linked polymer and a chemically cross-linked polymer or physically entangled copolymer containing living cells, such as chondrocytes, encapsulated therein. In a preferred aspect, the physically cross-linked polymer is selected from the group consisting of thermally gelling polysaccharides... Agent: Stinson Morrison Hecker LLP Attn: Patent Group
20090130757 - Bioreactor with mixer and sparger: A bioreactor and related methods are for use in bioprocessing in which a fluid is received and agitated using an internal fluid-agitating element driven by an external motive device. In one embodiment, the bioreactor includes a mixer and a movable sparger. The mixer may take the form of a rotational... Agent: King & Schickli, PLLC
20090130758 - Gene cry7ba1 encoding and insecticidal crystal protein of bacillus thuringiensis: The present invention discloses the isolation, cloning and use of insecticidal crystal proteins from Bacillus thuringiensis. The present invention isolates a novel insecticidal crystal protein gene cry7Bal from B. thuringiensis subsp. huazhongensis YBT-978 strain, and said gene encodes a novel insecticidal crystal protein Cry7Bal, which shows insecticidal activity against Lepidopteran... Agent: Scully Scott Murphy & Presser, PC
20090130759 - Culture medium containing kinase inhibitor, and use thereof: Pluripotent cells are maintained in a self-renewing state in serum-free culture medium comprising a gp130 agonist (LIF) and a GSK3 inhibitor.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090130761 - Freeze-dried product for introducing nucleic acid, oligonucleic acid or derivative thereof: A freeze-dried product of a complex containing a nucleic acid, oligonucleic acid or derivative thereof; a cationic polymer, or cationic lipid or aggregate containing the same; and, an anionic polymer; a method for preparing the freeze-dried product, comprising a step of forming a complex by mixing a nucleic acid, oligonucleic... Agent: Frishauf, Holtz, Goodman & Chick, PC
20090130760 - Method for the ubiquitination of common subunit of rna polymerases: The present invention provides a method for ubiquitinating RNA polymerases, comprising bringing the RNA polymerases into contact with BRCA1-BARD1.... Agent: Dickstein Shapiro LLP
20090130762 - Activation of hcv-specific t cells: The invention provides a method of activating hepatitis C virus (HCV)-specific T cells, including CD4+ and CD8+ T cells. HCV-specific T cells are activated using fusion proteins comprising HCV NS3, NS4, NS5a, and NS5b polypeptides, polynucleotides encoding such fusion proteins, or polypeptide or polynucleotide compositions containing the individual components of... Agent: Novartis Vaccines And Diagnostics Inc.
20090130763 - Method of controlling degradation of protein by tetracycline antibiotic: The present invention provides a fusion protein comprising a variant protein of a protein binding to an antibiotic and a target protein having fused thereto, wherein the variant protein is degraded when the antibiotic is not bound but stabilized when the antibiotic is bound in a cell, and the fusion... Agent: Morgan Lewis & Bockius LLP05/14/2009 > patent applications in patent subcategories.
20090123905 - Method of preserving early embryos of experimental animals by vitrification: This invention provides a solution for preserving mammalian early embryos or ES cells by vitrification, which comprises, as a base material, a phosphate buffer that exclusively contains 10% to 15% (v/v) propylene glycol as polyhydric alcohol or a phosphate buffer that exclusively contains 10% to 15% (v/v) propylene glycol and... Agent: Foley And Lardner LLP Suite 500
20090123907 - Lysine citrate for plasma protein and donor protection: An improved anticoagulant or additive is based on a higher level of citric acid than is usual (at least about 1.0% weight by volume). The higher citrate is combined with an amino acid as a counterion. The amino acid prevents cellular damage often caused by elevated citrate levels. The amino... Agent: Stefan Kirchanski
20090123906 - Reproductive cell system: Compositions or extracts (2)(15)(24)(25)(16)(23)(31)(36)(41) obtained from the fruit (4) or leaves (26) of plants of the genus Hippophea (1) and methods of using such compositions or extracts to reduce loss of reproductive cell function.... Agent: Craig R. Miles
20090123908 - Collecting device: A collecting device to be connected to at least one test tube, in which a sample is subjected to a wet combustion process, comprising a collector tube, which is arranged to collect and draw off from the test tube steam products from the wet combustion process. The collecting device further... Agent: Harness, Dickey & Pierce, P.L.C
20090123910 - Method of efficient extraction of protein from cells: Methods for producing a protein extract from cells, such as cells or cellular samples containing viral proteins, are provided. In general terms, the methods may involve: increasing the pH of the cells to a pH of at least about pH 10.0 to produce an intermediate composition, and then, in the... Agent: Wilson Sonsini Goodrich & Rosati
20090123909 - Rapid, informative diagnostic assay for influenza viruses including h5n1: A rapid diagnostic assay for influenza virus, particularly avian influenza and more particularly H5N1, is described. The assay is based on amplification of a significant portion of the hemagglutinin (HA) gene and sequencing of several loci within the HA gene, using techniques which can obtain real time sequence information from... Agent: Peters Verny , L.L.P.
20090123922 - Bead bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries: The present invention includes composition and methods for making and using a combinatorial library having two or more beads, wherein attached to each bead is a unique nucleic acid aptamer that have disposed thereon a unique sequence. The library aptamers may be attached covalently to the one or more beads,... Agent: Chalker Flores, LLP
20090123925 - Cancer therapy prognosis and target: The present invention relates to a gene and/or protein expression based method of predicting response to platinum based chemotherapy for lung cancer patients, as well as a method of predicting prognosis of survival based on protein expression and type of lung cancer. The invention also provides novel targets for screening... Agent: Myers Bigel Sibley & Sajovec
20090123913 - Detection of nucleic acid differences using endonuclease cleavage/ligase resealing reactions and capillary electrophoresis or microarrays: The present invention is directed to various methods for detecting DNA sequence differences, including single nucleotide mutations or polymorphisms, one or more nucleotide insertions, and one or more nucleotide deletions. Labeled heteroduplex PCR fragments containing base mismatches are prepared. Endonuclease cleaves the heteroduplex PCR fragments both at the position containing... Agent: Nixon Peabody LLP - Patent Group
20090123919 - Diagnosing pathological conditions using interallelic epigenetic variations: The present invention is of interallelic epigenetic alterations in cells of cancer-stricken individuals which can be used for diagnosing cancer or cancer risk. In addition, the present invention is of interallelic epigenetic pattern alterations and/or interallelic replication pattern alterations in cells of a conceptus having imbalanced chromosome(s) or in maternal... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20090123914 - Genomic assay: A method of detecting a nucleic acid sequence in a genomic sample, includes: providing the genomic sample containing a target nucleic acid sequence of a duplex nucleic acid; providing, a probe containing a probe nucleic acid sequence; providing a hybridization mixture containing the genomic sample, the probe, a hybridization promoting... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
20090123928 - Genomic landscapes of human breast and colorectal cancers: Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based... Agent: Banner & Witcoff, Ltd.
20090123915 - High throughput methods comprising analysis of repetitive element dna methylation: Preferred aspects provide novel high-throughput, sensitive methods (e.g., real-time PCR-based (MethyLight™) reactions) for detection and/or measurement of global genomic 5-methylcytosine content, based on measurement of DNA methylation of Alu, LINE-1 repetitive sequences, and the chromosome 1 centromeric satellite alpha and juxtacentromeric satellite 2 repeat sequences. Additional aspects provide sensitive methods... Agent: Davis Wright Tremaine, LLP/seattle
20090123918 - Human protooncogene trg and protein encoded therein: Disclosed are a protooncogene and a protein encoded by the same. The protooncogene of the present invention, known to be involved in human carcinogenesis, may be effectively used for diagnosing various cancers including uterine cancer, leukemia, lymphoma, colon cancer, lung cancer, skin cancer, etc.... Agent: Sughrue Mion, PLLC
20090123931 - Identification of tissue for debridement: Provided are methods of determining whether a cell in a tissue site is viable or nonviable. Also provided are methods of debriding tissue from a tissue site. Further provided are kits comprising a compound that distinguishes between viable and nonviable cells and instructions for using the compound on a tissue... Agent: Kinetic Concepts, Inc. C/o Sonnenschein Nath & Rosenthal LLP
20090123921 - Immunoglobulin libraries: Methods and compositions for the screening and isolation of ligand-binding polypeptides, such as antibodies. In some aspects, methods of the invention enable the isolation of intact soluble antibodies comprising a constant domain. Screening methods that employ genetic packages such as bacteria and bacteriophages enable high through-put identification of ligand binding... Agent: Fulbright & Jaworski, L.L.P.
20090123934 - Inhibition of polo kinase by matrimony maintains g2 arrest in the meiotic cell cycle: Matrimony (Mtrm) acts as a negative regulator of Polo kinase (Polo) during the later stages of G2 arrest. Indeed, both the repression of Polo expression until stage 11 and the inactivation of newly synthesized Polo by Mtrm until stage 13 play critical roles in maintaining and properly terminating G2 arrest.... Agent: Kevin C. Hooper Bryan Cave LLP
20090123927 - Isolation of precursor cells and their use for tissue repair: Cartilage-derived morphogenetic protein CDMP-1 or a transforming growth factor β having at least 80% homology with CDMP-1, or a factor co-expressed and/or co-detectable therewith, is used as a marker of skeletal precursor cells from any part of a mammalian body.... Agent: Clark & Elbing LLP
20090123920 - Jak2 mutations: The invention disclosed herein is based on the identification of novel mutations in the JAK2 gene and JAK2 protein. The invention provides methods and compositions useful for diagnosing neoplastic diseases including, for example, myeloproliferative diseases. The invention also provides methods and compositions useful for determining a prognosis of an individual... Agent: Foley & Lardner LLP
20090123935 - Measurement of a population of nucleic acids, in particular by real time pcr: The invention relates to a method for measuring the amount of nucleic acids of a target sequence in a sample of interest. The method comprises several steps, and in particular subjecting the sample of interest to an amplification treatment, in the presence of at least one nucleic acids label specific... Agent: Nixon & Vanderhye, PC
20090123924 - Method for breast cancer diagnosis: e
20090123923 - Method for obtaining information regarding quantity of dna after non-methylated cytosine converting treatment in analysis of dna methylation: The present invention provides an easy and accurate method for obtaining information regarding a quantity of DNA included in a sample used for analyzing a methylation of a target DNA, comprising steps of: treating a biological sample containing DNA including the target DNA with a non-methylated cytosine converting agent for... Agent: Sughrue Mion, PLLC
20090123926 - Method for the diagnosis of genetic diseases by molecular combing and diagnostic kit: The invention concerns a method for detecting or locating one or several genes of one or several specific A DNA sequence or one or several molecules reacting with DNA on a B DNA characterised in that it consists in: (a) fixing and combing a certain amount of said B DNA... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090123930 - Methods and compositions for diagnostic use in cancer patients: Disclosed herein are methods and compositions useful for identifying therapies likely to confer optimal clinical benefit for patients with cancer.... Agent: Genentech, Inc.
20090123929 - Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases: The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering... Agent: Casimir Jones, S.c.
20090123917 - Methods for quantifying microrna precursors: Provided herein is a sensitive, high throughput, real-time PCR assay to monitor the expression of miRNA precursors. Gene specific primers and reverse transcriptase were used to convert the primary precursors and pre-miRNAs to cDNA. The expression of 23 miRNA precursors in six human cancer cell lines was assayed using the... Agent: Calfee Halter & Griswold, LLP
20090123912 - Methods for quantitating small rna molecules: In one aspect, the present invention provides methods for amplifying a microRNA molecule to produce DNA molecules. The methods each include the steps of: (a) using primer extension to make a DNA molecule that is complementary to a target microRNA molecule; and (b) using a universal forward primer and a... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20090123933 - Microrna biomarkers in lupus: The present invention provides methods of screening a subject for systemic lupus erythematosus (SLE), comprising detecting an increase in an amount of one or more markers associated with SLE in a biological sample from the subject, wherein the one or more markers is selected from the group consisting of miR-16-1,... Agent: Myers Bigel Sibley & Sajovec
20090123932 - Quantitative test to detect disease progression markers of epithelial ovarian cancer patients: The present invention concerns a method of prognosing the risk of early ovarian cancer relapse in a subject having ovarian cancer comprising: a) detecting the level of at least one marker selected from the group consisting of BTF4, GCS and HLA-DRbeta1; and b) comparing the level of the above at... Agent: Goudreau Gage Dubuc
20090123936 - Conformationally abnormal forms of tau proteins and specific antibodies thereto: The invention relates to antibodies with a specificity to an abnormally truncated form of tau protein, which is conformationally different from normal tau, and does not bind to normal tau protein, conformationally different tau proteins (“tauons”) and diagnostic and therapeutical aspects in relation to Alzheimer's disease and related tauopathies.... Agent: Fulbright & Jaworski L.L.P.
20090123937 - Methods of selecting epidermal growth factor receptor (egfr) binding agents: The present application relates to methods of selecting EGFr binding agents. In certain embodiments, such EGFr binding agents bind to at least a portion of a panitumumab epitope on an EGFr. In certain embodiments, such EGFr binding agents do not bind to a panitumumab epitope on an EGFr.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090123939 - Biologically enhanced electrically-active magnetic nanoparticles for concentration, separation, and detection applications: The disclosure generally relates to a particulate composition formed from a conductive polymer (e.g., conductive polyanilines, polypyrroles, polythiophenes) bound to magnetic nanoparticles (e.g., Fe(II)- and/or Fe(III)-based magnetic metal oxides). The particulate composition can be formed into a biologically enhanced, electrically active magnetic (BEAM) nanoparticle composition by further including a binding... Agent: Ian C. Mcleod Ian C. Mcleod, P.C.
20090123938 - Mammalian monocyte chemoattractant protein receptors: Novel human chemokine receptors, MCP-1RA and MCP-1RB, and processes for producing them are disclosed. The receptors, which are alternately spliced versions of MCP-1 receptor protein may be used in an assay to identify antagonists of MCP-1 which are therapeutically useful in the treatment of atherosclerosis and other diseases characterized by... Agent: Townsend And Townsend And Crew, LLP
20090123940 - Molecules involved in synaptogenesis and uses therefor: The present invention is based on the discovery that neuronal pentraxins play a role in the clustering and internalization of AMPA receptors, synaptogenesis, and metabotropic glutamate receptor-mediated long term depression (LTD) of a synapse. Accordingly, there are provided methods of identifying compounds that that modulate mGluR-mediated AMPA receptor internalization and... Agent: Dla Piper LLP (us)
20090123947 - Analytical sandwich test for determining nt-probnp: The present invention concerns an immunological test for determining NT-proBNP comprising at least two antibodies to NT-proBNP, wherein at least one of the antibodies to NT-proBNP is a monoclonal antibody. The epitopes recognized by the antibodies can slightly overlap.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090123944 - Bioassays: The invention relates to vectors encoding bioassay receptors and in vitro bioassays using said bioassay receptors for assessing compounds of interest. In particular, the bioassays provide a generic platform for the comparison of binding of different ligands to their respective receptors or binding partners in the presence and/or absence of... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090123943 - Characterization and identification of unique human adiponectin isoforms and antibodies: The invention pertains to methods for measuring different forms of human adiponectin that are present in human plasma/serum, and more specifically methods are based on an ELISA assay that utilizes different monoclonal antibodies directed against adiponectin, in combination with different polyclonal antibodies directed against different domains of human adiponectin. The... Agent: Hoffmann-la Roche Inc. Patent Law Department
20090123945 - Cholinergic/serotoninergic receptor and uses thereof: The present invention describes new cholinergic/serotoninergic chimeric receptors and provides methods and compositions suitable for screening for ligands such as agonists, antagonists and allosteric modulators of α7 nicotinic acetylcholine receptors.... Agent: Paul D. Yasger Abbott Laboratories
20090123942 - Electrophysiological assays using oocytes that express human enac and the use of phenamil to improve the effect of enac enhancers in assays using membrane potential reporting dyes: In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste tissue. The present invention further relates to amphibian oocyte-based... Agent: Hunton & Williams LLP Intellectual Property Department
20090123946 - Immunoassays and kits for the detection of ngal: The present invention relates to NGAL immunoassays and kits, and to methods of using glycosylated mammalian NGAL and antibodies that bind to mammalian NGAL in immunoassays and kits. Among other things, the methods and kits can be employed to determine the amount of human NGAL monomer in a test sample,... Agent: Paul D. Yasger Abbott Laboratories
20090123948 - Autoantibody detection for cancer diagnostics: The present invention relates to compositions and methods for the detection of anti-ECPKA autoantibodies in a biological sample, and to the use of such compositions and methods in the diagnosis of cancer in humans and non-human mammals.... Agent: Leydig, Voit & Mayer, Ltd.
20090123950 - Generation and profiling of fully human hucal gold®-derived therapeutic antibodies specific for human cd38: The present invention provides novel methods for using recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorders or conditions. These methods take advantage of newly discovered antibodies and surprising properties of such antibodies, such... Agent: Foley And Lardner LLP Suite 500
20090123949 - Methods for determining the prognosis for cancer patients using tucan: The invention provides methods for determining a prognosis for survival for a cancer patient. One method involves (a) measuring a level of a TUCAN in a neoplastic cell-containing sample from the cancer patient, and (b) comparing the level of TUCAN in the sample to a reference level of TUCAN, wherein... Agent: Mcdermott, Will & Emery
20090123941 - Method and kit for detecting the early onset of renal tubular cell injury: A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected in the urine following renal tubule cell injury. NGAL protein expression is detected predominantly in... Agent: Hasse & Nesbitt LLC
20090123951 - Method of diagnosing a body weight condition or predisposition: A method for diagnosing a body weight condition or predisposition to a body weight condition in an animal by determining observed level(s) of at least one biomarker in a tissue or biofluid sample from the animal and comparing the observed level(s) to reference level(s) for the biomarker; wherein the observed... Agent: Colgate-palmolive Company
20090123952 - Method of measuring amyloid-beta peptides: The present invention relates to methods for measuring Aβ peptides in a sample, particularly a sample of blood, such as whole blood and plasma, and to methods of determining whether a compound alters the amount of Aβ produced by a cell or animal.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090123953 - Double brilliance beta-arrestin: a biosensor for monitoring the activity of receptors and signalling molecules, and method of using same: An intramolecular bioluminescence resonance energy transfer (BRET), biosensor for monitoring receptor activity and signalling cascades is disclosed. The “double-brilliance” biosensor sandwiches β-arrestin (β-arr) between Renilla luciferase (Luc) and the yellow fluorescent protein (YFP). β-arr associates with G-protein coupled receptors GPCR following receptor activation, bringing Luc and YPF into close proximity... Agent: Quarles & Brady LLP
20090123954 - Multicolor bioluminescent visualization probe set, or single-molecule-format multicolor bioluminescent visualization probe: By using a living cell line transfected with gene of multicolor luminescent probe set or single-molecule-format multicolor bioluminescent probe, it becomes possible to distinguish and detect bioactivity level of a target ligand in a complex context of the living cell two-dimensionally (wavelength versus intensity) in multi colors, and to quantitatively... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20090123955 - Size self-limiting compositions and test devices for measuring analytes in biological fluids: A test strip or electrochemical sensor for measuring the amount of an analyte in a hiological fluid, e.g., the glucose content of whole blood, includes a size self-limiting reagent formulation employing an enzyme system for reaction with the analyte, the reactive system mixed into a water-soluble swellable polymer matrix containing... Agent: Nixon Peabody LLP
20090123957 - Canine cox-2 proteins and uses thereof: The present invention relates to canine COX-1 and COX-2 proteins; to canine COX-1 and COX-2 nucleic acid molecules, including those that encode such COX-1 and COX-2 proteins, respectively; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods... Agent: Heska Corporation Legal Department
20090123956 - Measurement of the oxidants-antioxidants balance in liquids: The present invention describes a chemical method that can determine the oxidant-antioxidant balance in biological samples and other materials. In the example of the application of the invention that is presented in the description of the invention section 3,3′,5,5′-Tetramethylbenzidine (TMB) and its cation that has a characteristic color are used... Agent: Koliakos George
20090123958 - Laboratory devices, methods and systems employing acoustic ejection devices: A method for performing chemically analyzing samples (e.g. bodily fluids) dispensed with an acoustic ejection device is disclosed. A method preparing a sample for analysis by centrifuging the sample in a sample collection device in fluid communication with an acoustic ejection device is disclosed. A method for laboratory analysis of... Agent: The Nath Law Group
20090123960 - Method for removing antibiotics from blood culture samples: Methods for removing inhibitors of microbial growth, including antibiotics, from a biological sample suspected of containing one or more microorganisms are provided. The methods include contacting a sample, or a culture growth medium containing the sample, with reversed-phase adsorbent media, which remove the inhibitors of microbial growth, but allow the... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20090123961 - Microfluidic device having stable static gradient for analyzing chemotaxis: A microfluidic method and device for testing and analyzing chemotaxis by providing a stable, static fluid gradient. The device includes a sink reservoir for receiving biological cellular material and a source reservoir for receiving a chemoattractant. The biological cellular material migrates through a low fluid volume microfluidic gradient channel located... Agent: Quarles & Brady LLP
20090123959 - Microorganism discriminator and method: A microorganism discriminator is disclosed, including a housing to incubate a sample in low-light conditions; a illuminator to irradiate the sample with a monochromatic blue light; an injector disposed in the housing, to deliver a viability discriminating dye to the sample; and a base connected to the housing and the... Agent: Stein, Mcewen & Bui, LLP
20090123962 - Chemical sensing device: The present application relates to a chemical sensing device for detecting an analyte in a liquid sample containing suspended particles. The device comprises a radiation source adapted to generate electromagnetic radiation, a transducer (3) having a pyroelectric or piezoelectric element and electrodes which is capable of transducing a change in... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090123963 - Biopsy sample mount and processing method: A biopsy sample mount and processing method. One embodiment of the sample mount includes a rounded mass of hydrophilic or liquid absorbing material. Tissue samples can be releasably placed on the material mass in a known structural orientation and the mount and sample immersed in fixative. The mass of material... Agent: Faegre & Benson LLP Patent Docketing - Intellectual Property
20090123964 - Novel gene gms 08: The present invention relates to microorganisms genetically engineered to increase yield and/or efficiency of biomass production from a carbon source, such as e.g. glucose. Processes for generating such microorganisms are also provided by the present invention. The invention also relates to polynucleotide sequences comprising genes that encode proteins that are... Agent: Nixon & Vanderhye, PC
20090123965 - Hydrolysis process for raw materials from the fishing and slaughterhouse industries and tanks for use therein: Method for an enzymatic hydrolysis process of collagen and raw materials containing proteins. The raw materials undergo enzymatic hydrolysis to produce the three layers: a top layer containing fat, a mid layer comprising water soluble constituents, and a non-soluble bottom layer comprising bones and non-soluble proteins. These layers are separated... Agent: Dennison, Schultz & Macdonald
20090123968 - Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have... Agent: Wilson Sonsini Goodrich & Rosati
20090123970 - Glycosylated mammalian ngal and use thereof: The present invention relates to glycosylated mammalian NGAL, and methods of using said glycosylated mammalian NGAL.... Agent: Paul D. Yasger Abbott Laboratories
20090123966 - Hybrid portable origin of replication plasmids: The invention relates to modifying plasmid origins of replication to create hybrid origins of replication containing nucleotide sequences from more than one plasmid. The invention also relates to a modified origin of replication cassette that is portable or exchangeable due to the creation of multiple cloning sites flanking the origin... Agent: Howrey LLP
20090123967 - Modified spider silk proteins: The present invention is directed to a method of modifying a spider silk protein and a spider silk protein obtainable by said method. The invention further pertains to a nucleic acid sequence coding for a modified spider silk protein, a vector containing said sequences and host cells transformed with this... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20090123969 - Novel fluorescent protein and gene encoding the same: The present invention provides a novel fluorescent protein the wavelength of the maximum of the fluorescence of which exists in a wavelength side longer than 510 nm, and which exhibits yellow fluorescence or yellowish green fluorescence and can be expressed in a heterogeneous cell, and a gene encoding the same,... Agent: Sughrue Mion, PLLC
20090123971 - Compositions of aminoacyl-trna synthetase and uses thereof: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNA's/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.
20090123974 - Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated... Agent: K&l Gates LLP
20090123973 - Methods of making modular fusion protein expression products: The invention relates to methods of making modular chimeric protein expression products and compositions utilized in the methods. In particular, the invention relates to sequential, directional cloning of polynucleotides encoding polypeptide modules. Each clonable element or module contains an open reading frame of interest flanked by predetermined restriction sites. The... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20090123972 - Staphylococcal nuclease fusion proteins for the production of recombinant peptides: Peptides are produced as fusions with a suitable carrier protein. The carrier protein disclosed herein are adapted from the N-terminal domain of staphylococcus nuclease. This novel carrier protein acts to promote the over-expression of the peptide-protein fusion in the form of inclusion bodies, which minimizes in-cell proteolysis of desired peptides.... Agent: Ogilvy Renault LLP
20090123975 - Feed media: The invention provides stable feed media containing pyruvate and methods for stabilizing feed media by adding pyruvate. The invention further provides methods for producing proteins using such media and proteins produced through the use of such methods.... Agent: Amgen Inc. Law Department
20090123976 - Compositions and method for storage of nucleic acid from bodily fluids: An aqueous composition comprising a denaturing agent, a chelator, a buffering agent and a protease for the extraction of nucleic acid from a sample of bodily fluid, such as saliva, such that the extracted nucleic acid is stable for at least fourteen days at room temperature and can be directly... Agent: Clark & Elbing LLP
20090123977 - System for capturing and modifying large pieces of genomic dna and constructing organisms with synthetic chloroplasts: The functional analysis of genes frequently requires the manipulation of large genomic regions. A yeast-bacteria shuttle vector is described that can be used to clone large regions of DNA by homologous recombination. Also described is a method for isolating entire genomes, including chloroplast genomes, or large portions thereof, and manipulating... Agent: Wilson Sonsini Goodrich & Rosati
20090123978 - Biological sample reaction chip and biological sample reaction method: A biological sample reaction chip, including: a plurality of reaction vessels; a first channel connected to one end of each of the reaction vessels and comprising an opening for introducing a reaction solution; and a second channel connected to the other end of each of the reaction vessels, wherein when... Agent: Harness, Dickey & Pierce, P.L.C
20090123911 - Isolated staphylococcus dnax subunit and use thereof: The duplex DNA of chromosomes is replicated in a multicomponent process. A helicase unwinds the DNA, a replicase synthesizes new DNA, and primase repeatedly synthesizes new primed starts on the lagging strand. The present invention is directed to the genes from Gram positive bacterium encoding these proteins, and their characterization.... Agent: Michael L. Goldman Nixon Peabody LLP
20090123979 - Methods of reducing the inhibitory effect of a tannin on the enzymatic hydrolysis of cellulosic material: The present invention relates to methods of producing a cellulosic material reduced in a tannin, comprising treating the cellulosic material with an effective amount of a tannase to reduce the inhibitory effect of the tannin on enzymatically saccharifying the cellulosic material. The present invention also relates to methods of saccharifying... Agent: Novozymes, Inc.
20090123980 - Process for producing l-arginine, l-ornithine or l-citrulline: The present invention provides a polypeptide which has: (i) an amino acid sequence wherein one or more amino acid residues are substituted in the region at positions 20 to 38 from the N terminus of the amino acid sequence shown in SEQ ID NO: 1; or (ii) an amino acid... Agent: Fitzpatrick Cella Harper & Scinto
20090123981 - Xylan-utilization regulon for efficient bioprocessing of hemicellulose and uses thereof: The subject invention provides at least one nucleic acid sequence encoding an aldouronate-utilization regulon isolated from Paenibacillus sp. strain JDR-2, a bacterium which efficiently utilizes xylan and metabolizes aldouronates (methylglucuronoxylosaccharides). The subject invention also provides a means for providing a coordinately regulated process in which xylan depolymerization and product assimilation... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090123982 - Triglyceride process: A process for producing triglycerides which comprises: (a) subjecting a first triglyceride comprising at least 40% by moles of oleic acid residues, based on total acyl groups in the triglyceride, to an alcoholysis reaction with an alcohol having from 1 to 6 carbon atoms to obtain a composition comprising 2-oleoyl... Agent: Morgan Lewis & Bockius LLP
20090123983 - Processes for preparing an intermediate of sitagliptin via enzymatic reduction: The invention provides enzymatic reduction processes for the preparation of 4-(2,4,5-trifluorophenyl)-3-hydroxybutanoate, particularly, (S)-methyl 4-(2,4,5-trifluorophenyl)-3-hydroxybutanoate, a key intermediate in the synthesis of Sitagliptin, and the (S)- and (R)-enantiomers of methyl 4-(2,4,5-trifluorophenyl)-3-hydroxybutanoate in high enantiomeric purity.... Agent: Kenyon & Kenyon LLP
20090123984 - Transformed plants accumulating terpenes: The present invention relates to transformed plants with an altered terpene content, preferably over-accumulating a mono- or sesqui-terpene. By transformation of plants with genes encoding terpene synthases (TS), and prenyl transferases (PRT), plants accumulating at least 1000 ng/per g of fresh leaf of a specific terpene were obtained. The present... Agent: Winston & Strawn LLP Patent Department
20090123985 - Method for fabricating aerogels and their application in biocomposites: The present invention discloses a method for fabricating aerogels, a method for fabricating surface-modified aerogels, and a method for fabricating biocomposites. Take the fabricating method of biocomposites for example, first, a precursor solution is provided and the precursor solution comprises a hydrophilic ionic liquid, a catalyzed hydrolysis and/or condensation reagent,... Agent: Wpat, PC
20090123986 - Nematode phosphoethanolamine n-methyltransferase-like sequences: Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.... Agent: Fish & Richardson PC
20090123987 - Extracting and purifying limit dextrinases: The invention relates to improved methods for extracting and purifying limit dextrinase enzymes from cells, in particular plant cells. The process of the invention includes heating a cell homogenate at 4O° C., in the presence of divalent cations thus increasing the specific activity of the limit dextrinase.... Agent: Ballard Spahr Andrews & Ingersoll, LLP
20090123988 - Method for the specific or non-specific separation of cells and/or viruses from liquid media and the use thereof: The invention relates to a method for the specific or non-specific separation of cells and/or viruses from liquid media which is based on adsorption of the species on a correspondingly functionalised carrier material. The method according to the invention is used for separation and also isolation of any species of... Agent: Leydig Voit & Mayer, Ltd
20090123989 - Virus purification using ultrafiltration: The invention provides a method for the purification, of a virus comprising a step of ultrafiltration wherein the reteniate contains the virus, wherein back pressure of at least 5 kPa is applied on the permeate side. The invention also provides a method for purification of a recombinant adenovirus, said method... Agent: Traskbritt, P.C.
20090123990 - Composition comprising enzymatically digested yeast cells and method of preparing same: The present invention relates to the field of fermentation media. More specifically, the invention provides a method for preparing a composition useful for culturing microbial cells wherein whole and/or autolysed yeast cells are enzymatically treated to obtain the composition. The microbial cultures obtained have increased stability and are useful in... Agent: Foley And Lardner LLP Suite 500
20090123991 - Retrons for gene targeting: The invention provides methods and nucleic acid constructs that may be used to modify a nucleic acid of interest at a target locus within the genome of a host. In some aspects, the invention contemplates producing in vivo a gene targeting substrate (GTS), which may be comprised of both DNA... Agent: Klarquist Sparkman, LLP
20090123992 - Shape-shifting vitrification device: This invention is a storage device (cryocontainer) for the vitrification method of cryopreservation that uses shape memory materials to create a novel shape-shifting feature in which the relevant heat transfer zone of the cryocontainer can be thermally morphed between a shape conducive to biological specimen handling and to a shape... Agent: Markets, Patents & Alliances LLC
20090123993 - Bioreactor for development of blood vessels: The present invention provides a blood vessel bioreactor and accessory system to harvest, maintain, transport, and/or develop a native blood vessel or a tissue-engineered biosynthetic blood vessel construct in which regulated nutritive fluid flow as well as a pressure and shear stress regimen is supplied which nutritionally and mechanically conditions... Agent: The Webb Law Firm, P.C.
20090123994 - Lockable signalling column: The invention relates to a signalling column with levels which are assembled by means of a relative pivoting limited in amplitude and interconnected by means of axially-extending conductors. The body of a level (A) has a locking bar (30) which extends axially to penetrate an opening (23) in the adjacent... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090123995 - Waste treatment system: A waste treatment system comprising an impermeable container adapted to accommodate waste, and presenting at least an opening for introducing waste and a plurality of preferential breaking lines for creating respective openings; air-tight closing element of the opening; percolate introduction element within the impermeable container; collector for the formed biogas;... Agent: Volpe And Koenig, P.C.
20090123996 - Vitrification device with shape memory seal: A closing device to create a seal in a cryocontainer for a biological specimen utilizes the temperature-induced phase transformation of shape memory materials to cause an actuator to toggle between a sealed and unsealed state. The temperature inducement occurs naturally within the normal temperature changes that occur during cryogenic vitrification... Agent: Markets, Patents & Alliances LLC
20090123997 - Modulators of odorant receptors: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and... Agent: Casimir Jones, S.c.
20090123999 - Nucleotide sequences invovled in plant disease resistance: The present invention relates to methods for producing plants having enhanced disease resistance. NRC1 proteins and nucleic acid sequences encoding these are provided, as well as transgenic plants producing NRC1 proteins.... Agent: Townsend And Townsend And Crew, LLP
20090124000 - Recombinant vectors: Methods and materials are provided for integrating heterologous nucleic acids into the genome of a cell or virus without disrupting expression of genes adjacent to the insertion site.... Agent: Merck And Co., Inc
20090123998 - Signature encoding sequence for genetic preservation: The present invention describes a method for fabrication of nucleic acid-based medium for storage of socially valuable information. This medium offers the possibility of simple and efficient reproduction of the information and cm be used for preserving information over periods of time, far surpassing those currently achievable by information storage... Agent: Alexey Zdanovsky
20090124001 - 9-amino-acridine derivatives and their use for eliminating misfolded proteins: The invention relates to compounds according to general formula (1) and/or their enantiomers, diastereomers as well as their pharmaceutically compatible salts, and to the use thereof for producing a medicament suited for treating diseases associated with misfolded proteins.... Agent: Rankin, Hill & Clark LLP
20090124002 - Alpha-1d calcium channel expressed in atrium: Novel calcium channel nucleic acids and polypeptides are disclosed herein. Methods of using the novel nucleic acids and polypeptides are also disclosed.... Agent: Wyeth Patent Law Group
20090124003 - Modulators of odorant receptors: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and... Agent: Casimir Jones, S.c.
20090124004 - Insect desiccation resistance genes and uses thereof: An objective of the present invention is to provide polynucleotides encoding insect desiccation resistance proteins, and uses thereof. cDNA libraries were produced from Polypedilum vanderplanki larvae in a desiccated state, a P. vanderplanki EST database was constructed, and genes encoding LEA proteins were isolated. This resulted in the successful isolation... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20090124005 - Enhanced expression and stability regions: Expression-enhancing nucleotide sequences for expression in eukaryotic systems are provided that allow for enhanced and stable expression of recombinant proteins in eukaryotic cells. Enhanced expression and stability regions (EESYRs) are provided for expression of a gene of interest in a eukaryotic cell. Chromosomal loci, sequences, and vectors are provided for... Agent: Regeneron Pharmaceuticals, Inc
20090124006 - Serum-free culture medium for the production of recombinant gonadotropins: The present invention is in the field of the manufacture of recombinant proteins. More specifically, it relates to the use of a serum-free culture medium comprising an antioxidant for the production of recombinant dimeric gonadotropins. The antioxidant may be selected from the group consisting of L-glutathione, 2-mercaptoethanol, L-methionine and a... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090124007 - Method for the simultaneous primary-isolation and expansion of endothelial stem/progenitor cell and mesenchymal stem cell derived from mammal including human umbilical cord: Disclosed herein is a method for isolating and culturing the endothelial stem/progenitor cells and mesenchymal stem cells derived from the umbilical cord of mammals, including human beings. More specifically, disclosed are a method for isolating and culturing endothelial stem/progenitor cells and mesenchymal stem cells at high purity from the umbilical... Agent: Greenlee Winner And Sullivan P C
20090124008 - Peptides for use in culture media: The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20090124009 - Antisense modulation of ptp1b expression: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.... Agent: Mcdermott Will & Emery
20090124010 - Peptide fractions promoting growth and synthesis of desired product (s) into cell and/or tissue culture: The invention relates to preparing and/or supplementing a cell or tissue culture medium. In particular, said invention relates to a serum-free and/or protein-free cell culture medium comprising peptide fractions isolated from rapeseeds, in particular rapeseeds cakes. A method for the production of a cell culture comprising said peptide fractions and... Agent: Birch Stewart Kolasch & Birch
20090124011 - Serum production system: Bovine serum compositions having controlled bovine serum characteristics and a method of producing such bovine serum compositions having such controlled serum characteristics from the whole blood of an offspring of a female bovine mammal.... Agent: Cr Miles, P.C. Craig R. Miles
20090124012 - Toxin/antitoxin systems and methods for regulating cellular growth, metabolic engineering and production of recombinant proteins: The present invention provides compositions and method for regulating cellular growth and metabolism, intra- and extracellular enzymatic activities, and synthesis of endogenous and/or heterologous proteins, comprising the steps of cloning genes encoding an mRNA interferase (toxin) and its cognate antitoxin; expressing these proteins in a host cell from two separate... Agent: Morrison & Foerster LLP
20090124013 - Stem-like cells: A method for the production and use of multipotential stem-like cells is disclosed. The preparation utilized in this method is characterized by the contact of low level electrical currents with cultures of fibroblasts or other -blast cells enriched by fibroblast growth factor and other nutrients. The electrical current is conducted... Agent: Knoble, Yoshida & Dunleavy
20090124014 - Method for homologous recombination in fungal cells: The present invention discloses a method to construct fungal cells having a target sequence in a chromosomal DNA sequence replaced by a desired replacement sequence, comprising: providing a DNA molecule comprising a first DNA fragment comprising a desired replacement sequence flanked at its 5′ and 3′ sides by DNA sequences... Agent: Nixon & Vanderhye, PC05/07/2009 > patent applications in patent subcategories.
20090117532 - Pre-clinical method for monitoring serial changes in circulating breast cancer cells in mice: The CellTracks® System provides a system to enumerate CTC's in blood. The system immunomagnetically concentrates epithelial cells, fluorescently labels the cells and identifies and quantifies CTC's. The absolute number of CTC's detected in the peripheral blood tumor load is, in part, a factor in prediction of survival, time to progression,... Agent: Philip S. Johnson Johnson & Johnson
20090117533 - Apparatus for producing and handling a flowing substance: A system (1) for producing a dough starter culture is provided which comprises a plurality of reservoirs (15) pre-loaded with a small amount (“mother level”) of a previously obtained starter culture. Into the reservoirs (15) are inoculated the other ingredients required for the preparation of starter culture and the contents... Agent: Baker, Donelson, Bearman, Caldwell & Berkowitz Intellectual Property Department
20090117534 - Compositions and assays utilizing adp or phosphate for detecting protein modulators: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the... Agent: Townsend And Townsend And Crew, LLP
20090117535 - Method for identifying hiv-1 protease inhibitors with reduced metabolic affects: The invention provides a novel in vitro method for identifying HIV-1 protease inhibitors with reduced potential for inducing metabolic abnormalities. The invention further provides diagnostic methods for identifying patients who may be at risk of developing metabolic abnormalities subsequent to the administration of an HIV-1 protease inhibitor. The invention also... Agent: Louis J. Wille Bristol-myers Squibb Company
20090117536 - Method and device for bacterial sampling: A bacterial detection sampling device comprising: a sampling medium for receiving a bacterial sample; and a plurality of bacteriophage. The bacteriophage are located on or in the sampling medium. Each bacteriophage comprises a nucleic acid encoding a protein capable of emitting light at an output wavelength.... Agent: Thompson Hine L.L.P. Intellectual Property Group
20090117537 - Method for detecting sars coronavirus: This invention provides: a method for detecting SARS pathogenic viruses with high sensitivity and rapidity for diagnosing severe acute respiratory syndrome (SARS); an oligonucleotide primer that can specifically hybridize with any nucleotide sequence constructed based on the nucleotide sequence of RNA polymerase of the SARS coronavirus; a method for nucleic... Agent: Sughrue Mion, PLLC
20090117549 - Aptamer-based methods for identifying cellular biomarkers: In this invention, a biomarker discovery method has been developed using specific biotin-labeled oligonucleotide ligands and magnetic streptavidin beads. In one embodiment, the oligonucleotide ligands are firstly generated by whole-cell based SELEX technique. Such ligands can recognize target cells with high affinity and specificity and can distinguish cells that are... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090117550 - Assessing brain aneurysms: This document provides methods and materials related to assessing brain conditions within mammals. For example, methods and materials that can be used to determine whether or not a mammal (e.g., a human) with a brain aneurysm is likely to experience brain aneurysm rupture are provided.... Agent: Fish & Richardson P.C.
20090117556 - Association of single nucleotide polymorphisms in the cbfa2t1 and decr1 genes with performance and carcass merit of beef cattle: Aspects of the present invention also provide novel compositions and methods based on novel CBFA2T1 and/or DECR1 single nucleotide polymorphisms selected from the group consisting of CBFA2T1 SNP1, CBFA2T1 SNP2, CBFA2T1 SNP3, CBFA2T1 SNP4, DECR1 SNP5, DECR1 SNP6, DECR1 SNP7, DECR1 SNP8, DECR1 SNP9, DECR1 SNP10, DECR1 SNP11, DECR1 SNP12... Agent: Judy Jarecki-black, Ph.d., Esq. C/o Merial Ltd.
20090117572 - Cell-based fluorescence resonance energy transfer (fret) assays for clostridial toxins: The present invention provides a method of determining clostridial toxin activity by (a) contacting with a sample a cell containing a clostridial toxin substrate that includes a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence containing... Agent: Allergan, Inc.
20090117565 - Compositions and methods for diagnosis and treating mood disorders: The present invention provides methods for diagnosing mental disorders such as mood disorders, including bipolar disorder I and II and major depression; The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders.... Agent: Townsend And Townsend And Crew, LLP
20090117566 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Goodwin Procter LLP Attn: Patent Administrator
20090117575 - Detection probe acting by molecular recognition: e
20090117561 - Differential expression gene profiles and applications in molecular staging of human gastric cancer: The invention provides methods for detecting differential gene expression in intestinal gastric tissue in a mammal by comparing the expression of specific genes in an intestinal gastric tissue suspected of being cancerous with that of the corresponding adjacent intestinal gastric tissue or a normal gastric mucosa tissue. The methods can... Agent: Morrison & Foerster LLP
20090117546 - Disease detection by digital protein truncation assays: Genetic diseases can be diagnosed by detection of mutations in causative genes. Protein truncation assays can be used to detect gene products of truncation-type mutations. However, the sensitivity of the assays is often insufficient to detect mutations present in a sample of DNA at a low frequency. Sensitivity can be... Agent: Banner & Witcoff, Ltd.
20090117539 - Dna sequences for gene suppression: The present invention provides methods of improving DNA sequences for gene suppression mediated by double-stranded RNA, and constructs and transgenic organisms containing such improved DNA sequences.... Agent: Monsanto Company
20090117564 - Estrogen receptor genes and utilization thereof: An estrogen receptor gene and utilization of the estrogen receptor gene. The estrogen receptor gene contains a nucleotide sequence coding for any of the following amino acid sequences: (a) the amino acid sequence of SEQ ID NO:1, (b) the amino acid sequence of SEQ ID NO:4, (c) the amino acid... Agent: Panitch Schwarze Belisario & Nadel LLP
20090117567 - Eubacterial tmrna sequences and uses thereof: The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090117568 - Eubacterial tmrna sequences and uses thereof: The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090117569 - Eubacterial tmrna sequences and uses thereof: The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090117570 - Eubacterial tmrna sequences and uses thereof: The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090117545 - Glycine riboswitches, methods for their use, and compositions for use with glycine riboswitches cross-reference to related applications: It has been discovered that certain natural mRNAs serve as metabolite-sensitive genetic switches wherein the RNA directly binds a small organic molecule. This binding process changes the conformation of the mRNA, which causes a change in gene expression by a variety of different mechanisms. Modified versions of these natural “riboswitches”... Agent: Patent Correspondence Arnall Golden Gregory LLP
20090117563 - Identification of trpml3 (mcoln3) as a salty taste receptor and use in assays for identifying taste (salty) modulators and/or therapeutics that modulate sodium transport, absorption or excretion and/or aldosterone and/or vasopressin production or release: This invention relates to the elucidation that TRPML3 is involved in salty taste perception in primates including humans and likely other mammals (given the significance of sodium and other ions to physiological functions and conditions this phenotype is likely strongly conserved in different animals). The invention also relates to the... Agent: Hunton & Williams LLP Intellectual Property Department
20090117571 - Impedance spectroscopy of biomolecules using functionalized nanoparticles: A biosensor system includes a functionalized interdigitated electrode, functionalized nanoparticles, a current/voltage signal generator, and a circuit analyzer. The interdigitated electrode can be functionalized by coating an exposed surface with first biomolecular probes. The nanoparticles are functionalized by coating an outer surface with second biomolecular probes. A signal generator provides... Agent: Marger Johnson & Mccollom, P.C.
20090117573 - Locus specific amplification using array probes: Methods are provided for multiplexed amplification of selected targets and analysis of the amplified targets. In preferred aspects the amplification and analysis take place on the same solid support and preferably in a localized area such as a bead or a feature of an array. In preferred aspects the analysis... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.
20090117562 - Method and kit for diagnosing autism using gene expression profiling: This invention relates to DNA microarray technology, and more specifically to methods and kits for identifying autism and autism spectrum disorders in humans.... Agent: Law Offices Of Khalilian Sira, LLC
20090117552 - Method for detection and quantification of target nucleic acids in a sample: The present invention relates to methods for multiplex detection and quantification of target nucleic acid sequences in a sample comprising the steps of: (i) providing a solid support having immobilized thereon an array of detector oligonucleotides, wherein said array of detector oligonucleotides is designed by random selection of non-eukaryotic genomic... Agent: Amster, Rothstein & Ebenstein LLP
20090117578 - Method for identifying type i diabetes mellitus in humans: A method and system for classifying subject populations utilizing predictive and diagnostic biomarkers for type I diabetes mellitus. The method including determining the levels of a variety of markers within the serum or plasma of a target organism and correlating this level to general populations as a screen for predisposition... Agent: Battelle Memorial Institute Attn:IPServices, K1-53
20090117558 - Method for improved specificity in probe based assays: Disclosed are compositions and methods for analyzing a target sequence in a sample. Generally, the method includes use of at least one pair of probes (Probe A and Probe B). In one embodiment, Probe A hybridizes to wanted and unwanted nucleic acid in the sample and bears a fluorophore and... Agent: Edwards Angell Palmer & Dodge LLP
20090117551 - Method for simultaneous analysis of multiple biological reactions or changes in in vivo conditions: It is an object of the preset invention to provide an activity measurement molecule necessary for measuring biological reactions or changes in in vivo conditions, and a method for measuring activity using the above activity measurement molecule. It is intended to provide an activity measurement molecule used for simultaneously analyzing... Agent: Pearne & Gordon LLP
20090117544 - Method of designing primers for use in method of detecting target nucleic acid and assay kit: A method of designing primers for use in a method of detecting an amplification product by hybridizing it with a probe, the amplification product is amplified from a target nucleic acid with the primers, including placing F3, F2 and F1 regions in this order from a 5′ terminal side and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090117560 - Method of forming self assembly substance on microsphere and method of detecting target analyte: It is intended to provide a method, in which the sensitivity in detecting a target analyte on a microsphere can be elevated and plural items can be detected at the same time. The presence of at least one target analyte in a sample is detected by bonding a microsphere having... Agent: Wenderoth, Lind & Ponack, L.L.P.
20090117543 - Methods and compositions for inducing sirtuins: Provided herein are compositions comprising agents that increase the level of expression of a sirtuin gene. Also provided are methods for purifying and isolating a factor from serum that stimulates the expression of a sirtuin gene. Diagnostic methods for determining whether a subject is calorically restricted or resistant to stress... Agent: Wolf Greenfield & Sacks, P.C.
20090117576 - Methods for analyzing nucleic acid: The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those... Agent: Casimir Jones, S.c.
20090117540 - Methods for detection of a target nucleic acid by forming a cleavage structure using an rna polymerase: The invention relates to compositions and methods for generating a signal indicative of the presence of a target nucleic acid in a sample, where the compositions and methods include an RNA polymerase, a FEN nuclease, and a probe.... Agent: Agilent Techologies Inc
20090117559 - Methods for determining probability of an adverse or favorable reaction to a niacin receptor agonist: The present invention relates generally to a GPR109A niacin receptor. The present invention relates more particularly to assessing a GPR109A polymorphism in an individual, wherein the GPR109A polymorphism is indicative of the subject's risk for an adverse reaction to the administration of a GPR109A receptor agonist, wherein the adverse reaction... Agent: Fish & Richardson P.C.
20090117538 - Methods for obtaining gene tags: The present invention provides methods for providing as tags the nucleotide sequences at the 5′ end of mRNA. The method of the present invention comprises the step of synthesizing cDNA using, as a template, mRNA whose CAP structure is linked with a IIs linker having a type IIs endonuclease recognition... Agent: Klarquist Sparkman, LLP
20090117541 - Methods of detecting tpmt mutations: Methods and compositions are described for use in the rapid and simultaneous screening of one or more samples for one or more mutations in the TPMT gene. The methods and compositions of the present invention can be used to rapidly determine if a mutation of the TPMT gene is present... Agent: Foley & Lardner LLP
20090117577 - Methods to identify compounds useful for tumor sensitization to dna damage: Cdc25A is herein identified as a substrate for β-TrCP1- or β-TrCP2-mediated ubiquitination and subsequent degradation via the ubiquitin-proteasome pathway. In particular, it has been found that interfering with β-TrCP expression or function, or increasing β-TrCP degradation, leads to accumulation of Cdc25A in a cell. Since degradation of Cdc25A is a... Agent: Darby & Darby P.C.
20090117555 - Microfluidic flow lysometer device, system and method: The invention provides a device, system and method that enables a microfluidic flow lysometer cell analyzer. Using a population of suspended living cells. cell surface molecule detection reagents, and cell cytoplasm (or nuclear) molecule detection reagents, this microfluidic cell analyzer can rapidly analyze a population of cells by running them... Agent: Stevens Law Group
20090117547 - Novel haplotype of human t2r receptor ht2r50 and its use in assays for identifying human bitter taste modulators: The present invention relates to the discovery of a novel haplotype of the human taste receptor hT2R50 in the T2R taste receptor family that responds to particular bitter ligands, i.e., 2-acetylpyrazine and ethylpyrazine. The present invention also relates to the use of this novel haplotype in assays for identifying ligands... Agent: Hunton & Williams LLP Intellectual Property Department
20090117553 - Nucleic acid melting analysis with saturation dyes: Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye... Agent: Ice Miller LLP
20090117554 - Polynucleotide and protein involved in synaptogenesis, variants thereof, and their therapeutic and diagnostic uses: The invention relates to a method and a kit for diagnosing autism linked to a mutation in a protein belonging to the family of human neuroligins.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090117557 - Rapid detection of microorganisms: Tools and methods for detecting the presence bacteria, yeast and mold in a sample obtained from a food sample are provided. The methods employ a polymerase chain reaction and primer and probe sets that are based on the 16S rRNA and squalene-hopene cyclase genes of Alicyclobacillus and Geobacillus and the... Agent: Calfee Halter & Griswold, LLP
20090117579 - Relating to the handling of dna: A variety of methods are provided which use a silicon or silicon dioxide channel to extract DNA from a sample and then release it at a later point. The extraction channels are simple to manufacture and reliable in use. Prior art problems with entrainment of gas, liquid and solid material... Agent: Fitch Even Tabin And Flannery
20090117574 - Self-actuating signal producing detection devices and methods: An assay system is provided of great sensitivity and portability where the presence of a specific target in a sample, as well as its concentration (qualification and quantification) is detected by reason of a potential or voltage in a closed circuit, built up a redox reaction. The reaction is produced... Agent: Jagtiani + Guttag
20090117542 - Unique short tandem repeats and methods of their use: Methods for DNA fingerprinting identification of human DNA samples, comprising: a) exposing a DNA sample of an individual to at least one primer specific for a Y chromosome polymorphism at a predetermined loci, said loci being chosen from OSU9, OSU14, OSU22, OSU35, OSU51, OSU57, OSU67, OSU70, OSU73, OSU77, with the... Agent: Calfee Halter & Griswold, LLP
20090117585 - Anti-fungal screening method: The present invention relates to a method for identification of anti-fungal agents and their mode of actions. In particular, it relates to cell wall disturbing anti-fungal agents and to an assay to identify them. More particularly, it relates to a screening method for the identification of an anti-fungal compound, which... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090117581 - Co-culture lymphoid tissue equivalent (lte) for an artificial immune system (ais): The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics,... Agent: Merchant & Gould PC
20090117582 - Diagnosis of allergic complaints, atopic diseases and/or auto-immune diseases by the identification of antibodies against cd28 in human serum: The invention relates to a method for diagnosing allergic complaints, atopic diseases and/or auto-immune diseases, according to which a sample from a patient is analysed for the presence of anti-CD28 auto-antibodies by bringing said sample into contact with CD28. If auto-antibodies bond to the CD28, this indicates the presence of... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.
20090117583 - Egf-like nucleic acids and polypeptides and uses thereof: The invention provides isolated nucleic acid molecules, designated ELVIS-1, ELVIS-2, and ELVIS-3 (for Epidermal Growth Factor-Like Variant In Skin-1,2, and 3). ELVIS nucleic acid molecules encode wholly secreted and transmembrane proteins with homology to EGF and TGF-α. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies.... Agent: Mcdermott Will & Emery LLP
20090117586 - Fungal cell wall synthesis gene: A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these... Agent: Townsend And Townsend And Crew, LLP
20090117587 - High-affinity monoclonal antibodies for botulinum toxin type a: High affinity antibodies for binding epitopes of BoNT/A and hybridomas that produce such antibodies are described. The antibodies may be used in a kit for detecting BoNT/A in a sample.... Agent: Usda-ars-office Of Technology Transfer Patent Advisors Office
20090117588 - Methods of diagnosing pre-eclampsia or eclampsia: Disclosed herein are kits for diagnosing pre-eclampsia and eclampsia or a propensity to develop pre-eclampsia or eclampsia that include agents for the detection of levels of free placental growth factor in a subject.... Agent: Clark & Elbing LLP
20090117584 - Non-human mammalian arthritis model featuring human antibodies against citrul-linated proteins: Use of a non-human mammalian disease model, wherein the non-human mammal has been implanted with human synovial tissue or other human inflamed tissue containing anti-CCP (cyclic citrullinated peptide) antibody producing cells for (i) analyzing cellular processes in a disease associated with anti-CCP antibodies in such human synovial tissue or other... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090117580 - Structure of prl-1 protein crystal and the method of crystallization thereof: The present invention relates to a crystal structure of PRL-1 (Phospatase of Regenerating Liver) protein and a method of crystallization thereof. It has been found that the PRL-1 protein has a tertiary structure having 5 strands of beta-sheet surrounded by 6 alpha-helices and well-arranged active site with closed P-loop, and... Agent: Kathleen A Tyrrell Licata & Tyrrell
20090117589 - Systems and methods for analyzing persistent homeostatic perturbations: This invention is in the field of homeostasis analysis. More particularly, it relates to systems and methods for analyzing persistent homeostatic perturbations, i.e. chronic stress, by measuring levels of biomarkers that are related to chronic stress. This invention is also directed to systems and methods for analyzing the molecular mechanisms... Agent: Dla Piper LLP (us)
20090117590 - Human calcium sensitive potassium channel beta3 subunit proteins, encoding nucleic acid and uses thereof: The present invention is directed to novel human DNA sequences encoding calcium sensitive potassium channel subunits β2, β3a, β3b, β3c, and β3d, the proteins encoded by the DNA sequences, vectors comprising the DNA sequences, host cells containing the vectors, and methods of identifying inhibitors and agonists of calcium sensitive potassium... Agent: Merck And Co., Inc
20090117594 - Method for measuring human megalin: This invention provides a method for measuring human megalin that can be performed in a simpler manner within a shorter period of time than is possible with conventional techniques, and that can also quantify human megalin. This invention also provides a method that enables diagnosis of functional diseases, which are... Agent: Foley And Lardner LLP Suite 500
20090117593 - T. cruzi-derived neurotrophic agents and methods of use therefor: The invention relates to T. cruzi trans-sialidase (TS) and to the neurotrophic and IL-6 secretion-inducing activities of the protein. TS, neurotrophic variants and/or neurotrophic peptides based upon the sequence of TS can be administered to a mammal to directly or indirectly provide neurotrophic support for neurons. A mammalian neurotrophic factor... Agent: Mcdermott Will & Emery LLP
20090117595 - Primary central nervous system tumor specific behab isoforms: The present invention comprises compositions and methods related to a glycosylation-variant BEHAB protein, poly-sialyated full-length BEHAB, and methods of use thereof.... Agent: Ropes & Gray LLP
20090117596 - Antibody-sensitized latex: Antibody-sensitized latex for use in determination of a bacterium belonging to the genus Nitrospira, the latex comprising latex particles each having a specific gravity of about 1.5 g/mL and an average particle diameter in the range of 1.0-1.5 μm and an antibody adsorbed thereon. The antibody is specific to a... Agent: Frishauf, Holtz, Goodman & Chick, PC
20090117592 - Altered intracellular localization of brk/sik protein tyrosine kinase in human prostate tumors: The invention provides methods for detecting abnormal prostate conditions, such as benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN), and adenocarcinoma, in an animal by comparing the amount of the Breast Tumor Kinase (BRK) tyrosine kinase in the nuclei of prostate luminal epithelial cells in a test sample with an... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090117591 - Fibrosis markers: The invention relates to the use of a combination of at least two markers that are selected from among Uromodulin, MAC2BP, AGP1 and Cathepsin A, for the in vitro detection of fibrotic alterations. In addition, the invention relates to a kit for determining the levels of said markers in a... Agent: Wenderoth, Lind & Ponack, L.L.P.
20090117597 - Method for measuring heptoglobin level in blood serum and kit therefor: The present invention relates to a method for measuring heptoglobin level in blood serum by using antibodies for α and β subunits of heptoglobin, and a kit for immunodetection of heptoglobin which comprises the antibodies for α and β subunits of heptoglobin for measuring heptoglobin level in blood serum. A... Agent: Fish & Richardson PC
20090117599 - Method of detecting sugar chains having glcnac transferred by gnt-v: It is intended to provide a method by which sugar chains having GlcNAc transferred by GnT-V can be accurately detected, screened and purified. In this detection method, two kinds of lectins differing in detailed GlcNAc-specificity are used together. As shown in FIG. 1(I), for example, a sample containing sugar chains... Agent: John Alexander Galbreath
20090117600 - Detection of biological molecules by differential partitioning of enzyme substrates and products: This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of... Agent: Ralph A. Dowell Of Dowell & Dowell P.C.
20090117601 - Methods and compositions for the detection of beta-lactamases: Presented herein are methods and compositions for the detection of specific beta-lactamases, including class A serine carbapenemases, metallo-beta-lactamases. AmpC beta-lactamases, and extended-spectrum beta-lactamases (ESBLs). The methods presented herein include methods that permit the detection of the presence of specific beta-lactamases in bacterial samples within as few as 2 to 10... Agent: Jones Day
20090117602 - Plasmodium diagnostic assay device: This invention relates to assays for a Plasmodium analyte in a liquid sample such as a body fluid. More particularly, the invention relates to a method and apparatus for the detection of a ligand in a body fluid such as urine or blood, which can diagnose malarial infection.... Agent: Edwards Angell Palmer & Dodge LLP
20090117603 - Sterilization indicator: The disclosed technology relates to a sterilization indicator and a process to concentrate signal generated by constraining it to a minimal surface, in a minimal volume and minimal pH and growth buffering or mediating influences. The sterilization indicator may comprise a carrier 12, the carrier having a first surface 14... Agent: Renner Otto Boisselle & Sklar, LLP
20090117604 - Proteolytic enzymes in urine as diagnostic parameters in diseases involving matrix remodelling: The present invention relates to a method for determining whether a urine sample has been obtained from a subject suffering from a kidney disorder involving kidney damage. The method is based on determining the level of a proteolytic enzyme in urine from the subject sample and optionally comparing this level... Agent: Young & Thompson
20090117606 - Measuring nanoparticle concentrations in tissue using diffuse optical spectroscopy: A non-invasive method to measure metal nanoparticle concentrations in bulk tissue is provided. A simple diagnostic assay to detect nanoparticle concentration in bulk tissue has been developed herein. One such provided method comprises: applying diffuse optical spectroscopy to a tissue having nanoparticles disposed therein; and applying an inverse algorithm to... Agent: Michelle M. Lecointe Baker Botts L.L.P.
20090117607 - Methods for differential detection of hypoxic tissue from a tissue sample of a mammalian subject: Methods are provided for detecting levels of low oxygen in a tissue of a mammalian subject by administering non-polar halogen compounds to the mammalian subject. Detection may be accomplished using imaging methods involving fluorescence immunohistochemical imaging of the halogen compound.... Agent: Woodcock Washburn LLP
20090117605 - Software integrated cytometric assay for quantification of the human polymorphonuclear leukocyte fctri receptor (cd64): The invention relates a method of quantifying CD64 and CD163 expression in leukocytes and, specifically to a kit for use with a flow cytometer including a suspension of quantitative fluorescent microbead standards, fluorescent labeled antibodies directed to CD64 and CD163, and analytical software. The software is used to take information... Agent: Edwards Angell Palmer & Dodge LLP
20090117608 - Apparatus for on-site microbial diagnosis and disinfection and method therefor: An apparatus for on-site microbial diagnosis and disinfection comprising a mobile unit for being brought to an infected site in the event of an emergency. The mobile unit comprises at least a first compartment and a second compartment. The first compartment comprises a laboratory for on-site microbial diagnosis of samples... Agent: Ladas & Parry LLP
20090117609 - Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins: A process of in vivo labeling and identifying recombinantly produced peptides or proteins within an unpermeabilized prokaryotic host cell. Recombinant prokaryotic cells expressing a fusion peptide comprising at least one tetracysteine tag were labeled in vivo using a biarsenical labeling reagent. A fluorescent activated cell sorter was used to identify... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090117611 - Device and method for wetting objects: The invention relates to a device and a method for wetting objects with a liquid by means of a system for carrying a specimen slide that is disposed at a distance from a platform. To reduce liquid consumption, the specimen slide is raised or lowered relative to the platform by... Agent: Harness, Dickey & Pierce, P.L.C
20090117610 - Methods and compositions for identifying a cell phenotype: A method of staining or pre-staining at least one cell is provided. The method comprising contacting the at least one cell with a staining agent selected from the group consisting of an extract of a Ficus elastica plant, a C23H44O4 and a proanthocyanidin, thereby staining or pre-staining the at least... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20090117613 - Method for redox reaction using an old yellow enzyme: A method of selective biooxidation to non activated carbon-hydrogen bonds of substances using a Geobacillus kaustophilus ‘Old Yellow Enzyme’ is provided”. It is shown that OYEs can be used to facilitate the biooxydation of substances, such as testosterone. It is also shown that OYE can introduce double bonds to form... Agent: Christie, Parker & Hale, LLP
20090117612 - Method of biooxidation using an old yellow enzyme: A method for a chemoselective and regioselective enzyme mediated oxidation of carbon-hydrogen bonds of substrates using a Geobacillus kaustophilus ‘Old Yellow Enzyme’ is provided. It is shown that OYEs can be used to facilitate the bioxidation of substrates, such as testosterone. It is also shown that the use of OYEs... Agent: Christie, Parker & Hale, LLP
20090117614 - Beta-mannanase from coffee berry borer, hypothenemus hampei, and uses thereof: The present invention relates to an isolated β-mannanase protein having an amino acid sequence which is 90% similar to the amino acid sequence of SEQ ID NO: 1, as well as isolated polynucleotides encoding the β-mannanase protein, and isolated expression systems and host cells containing the polynucleotides. The present invention... Agent: Nixon Peabody LLP - Patent Group
20090117616 - Methods for reducing or eliminating alpha-mannosidase resistant glycans for the production of glycoproteins: The present invention provides methods to reduce or eliminate α-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of α-mannosidase resistant glycans on glycoproteins results from the disruption of the newly isolated P. pastoris AMR2 gene encoding β1,2-mannosyltransferase. The present invention also discloses novel genes, polypeptides, antibodies, vectors... Agent: Merck And Co., Inc
20090117615 - Recombinant mammal cells, method of producing thereof, and method of producing proteins of interest: The present invention relates to a method of expressing an objective protein at a high level and stably as well as for a long period even in the absence of a selection drug with a recombinant mammal cell. More particularly, the present invention relates to a method of producing an... Agent: Wenderoth, Lind & Ponack, L.L.P.
20090117618 - Expression system for preparing il-15/fc fusion protein and its use: The invention relates to an expression system containing one or more nucleic acid(s) comprising at least one nucleic acid for an interleukin 15/Fc (IL-15/Fc) fusion protein, at least one promotor, at least one nucleic acid for a CD5 leader and, where appropriate, at least one nucleic acid for a selectable... Agent: Clark & Elbing LLP
20090117617 - Methods and compositions for targeted integration: Disclosed herein are methods and compositions for targeted integration of one or more copies of a sequence of interest using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain and integrase defective lentiviral donor constructs.... Agent: Robins & Pasternak
20090117619 - Carbohydrase expression during degradation of whole plant material by saccharophagus degradans: The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose, hemicellulose and other carbohydrates. These systems have a number of applications.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20090117620 - Automated analyzer for clinical laboratory: A laboratory automation system that is capable of carrying out clinical chemistry assays, immunoassays, amplification of nucleic acid assays, and any combination of the foregoing, said laboratory automation system employing at least one of micro-well plates and deep multi-well plates as reaction vessels. The use of micro-well plates as reaction... Agent: Paul D. Yasger Abbott Laboratories
20090117621 - Methods of nucleic acid amplification and sequencing: The invention relates to a method of amplifying one or more nucleic acid templates on a solid support in a nucleic acid amplification reaction, for example by solid-phase PCR using one or more amplification primers attached to the solid support. The method is characterised in that the amplification primers used... Agent: Klauber & Jackson
20090117622 - Mixture of reversibly inhibited enzymes: The invention relates to composition or a kit containing an enzyme that is reversibly inhibited by means of a chemical modification and an enzyme which is reversibly inhibited using non-covalent binding, the use of a mixture of enzymes reversibly inhibited in such a manner for processing or multiplying polynucleotides, and... Agent: Seed Intellectual Property Law Group PLLC
20090117548 - Analysis of hiv-1 coreceptor use in the clinical care of hiv-1 infected patients: A change in viral tropism occurs in many HIV positive individuals over time and can be indicated by a change in coreceptor usage from CCR5 to CXCR4. The change in coreceptor usage to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations... Agent: Frommer Lawrence & Haug
20090117623 - Method for producing l-amino acids by fermentation using bacteria having enhanced expression of xylose utilization genes: A method for producing an L-amino acid, such as L-histidine, L-threonine, L-lysine, L-glutamic acid, and L-tryptophan, using bacterium belonging to the genus Escherichia which has increased expression of genes, such as those of the xylABFGHR locus, which encode the xylose utilization enzymes, is disclosed. The method includes cultivating the L-amino... Agent: Cermak & Kenealy LLP Acs LLC
20090117624 - Process for the fermentative preparation of organic chemical compounds using coryneform bacteria in which the sugr gene is present in attenuated form: The invention relates to a recombinant coryneform bacterium which secretes an organic chemical compound and in which the sugR gene which codes for a polypeptide having the activity of an SugR regulator has been attenuated. The invention further relates to a processes for using this bacterium for the fermentative preparation... Agent: Law Office Of Michael A. Sanzo, LLC
20090117625 - Polypeptides and biosynthetic pathways for the production of monatin and its precursors: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include... Agent: Cargill, Incorporated
20090117626 - Process for preparing carboxylic acid using surfactant-modified enzyme: The present invention relates to a process for preparing a carboxylic acid using a surfactant-modified enzyme which comprises selectively reacting water and a carboxylic acid ester, provided that triglyceride is excluded, in an organic solvent in the presence of a surfactant-modified enzyme.... Agent: Birch Stewart Kolasch & Birch
20090117627 - Process for preparing enantiomerically enriched amines: e
20090117628 - Enzymatic processing in deep eutectic solvents: It has surprisingly been discovered that it is possible to use enzymes in deep eutectic solvents (DES). DES's are mixtures of a nitrogen salt or a metal salt and a strong hydrogen bond donor that can be mixed in proportions that form a eutectic point.... Agent: Dardi & Associates, PLLC
20090117629 - Isoprenoid wax ester synthases, isoprenoid acyl coa-synthetases, and uses thereof: The present invention provides isolated polynucleotides and isolated polypeptides. The polypeptides of the present invention have isoprenoid wax ester synthase activity or isoprenoid acyl CoA-synthetase activity. The present invention also includes methods of using the polynucleotides and polypeptides of the present invention. For instance, the methods include producing biodiesel and... Agent: Mueting, Raasch & Gebhardt, P.A.
20090117631 - Alcohol extraction process for biofuel production: This document describes a fermentation product producing or processing apparatus or process involving membrane pervaporation (PV) and either vapor permeation or distillation or both. The fermentation product may be produced semi-continuously wherein product concentration is maintained below a selected value by removal through pervaporation membranes. After a period of operation,... Agent: Bereskin And Parr
20090117630 - Fermentation product processes: The present invention relates to processes for production of an ethanol product from granular starch... Agent: Novozymes North America, Inc.
20090117633 - Process of producing ethanol using starch with enzymes generated through solid state culture: The present invention is directed to process of producing ethanol using starch with enzymes generated through solid state culture.... Agent: Morgan, Lewis & Bockius, LLP
20090117632 - Use of ethanol plant by-products for yeast propagation: Embodiments of the invention relate, for example, to methods for reducing the load of organic acids and glycerol in water recycled to the fermentation process. Organic acids and glycerol produced during ethanol fermentation are used as a replacement for carbohydrates for propagation of yeast. The yeast may be sold as... Agent: Buchanan Ingersoll & Rooney PC (archer Daniels Midland Company)
20090117635 - Process for integrating cellulose and starch feedstocks in ethanol production: The present invention is directed to process integrating cellulose and starch feedstocks to produce ethanol.... Agent: Morgan, Lewis & Bockius, LLP
20090117634 - Process of producing ethanol using cellulose with enzymes generated through solid state culture: The present invention is directed to process of producing ethanol using cellulose with enzymes generated through solid state culture.... Agent: Morgan, Lewis & Bockius, LLP
20090117636 - Method and apparatus for accelerating growth of e. coli by applying electric field: Disclosed are a method and an apparatus for accelerating the growth of E. coli by applying an electric field with a frequency in the range from 1 kHz to 1 MHz. The present invention is applicable to the enhancement of production of heterologous recombinant proteins and metabolites produced by E.... Agent: Cantor Colburn, LLP
20090117637 - Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface: This disclosure relates to substrates containing at least one polyphosphazene with a forming surface as matrices for producing biological materials that can be implanted in a mammal. The disclosure also relates to a method for producing such substrates and substrates containing polyphosphazene with a micro-structured surface.... Agent: Sutherland Asbill & Brennan LLP
20090117638 - Bilirubin oxidase mutant having thermal stability: A heat-resistant bilirubin oxidase mutant is disclosed. The bilirubin oxidase is obtained by deletion, replacement, addition or insertion of at least one amino acid residue of a wild type amino sequence of SEQ. ID. No. 1 of a bilirubin oxidase derived from an imperfect filamentous fungus, Myrothecium verrucaria.... Agent: K&l Gates LLP
20090117639 - Neural progenitor cell populations: This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates differentiation, and establishes the neural progenitor population. The progenitors can be further differentiated in... Agent: Geron Corporation Attn. David J. Earp
20090117640 - Transglutaminase variants with improved specificity: Variants of transglutaminase from S. mobareanse, which variants have improved selectivity against Gln-40 og Gln-141 of human growth hormone are provided.... Agent: Novo Nordisk, Inc. Intellectual Property Department
20090117641 - Mutated abl kinase domains: The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317,... Agent: Novartis Institutes For Biomedical Research, Inc.
20090117642 - Alpha-amylase variants with altered properties: Disclosed are compositions comprising variants of a parent G. stearothermophilus alpha-amylase that have alpha-amylase activity and which exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they are derived. The compositions comprise an additional enzyme such as a phytase. Also disclosed are methods of using the compositions, and... Agent: Genencor International, Inc. Attention: Legal Department
20090117644 - Recombinant hsv useful for treatment of human glioma: The present invention provides a recombinant HSV having the ability to specifically kill tumor cells such as human glioma cells in vivo, useful and safe for treating human glioma, etc. and that can easily put to clinical use. A new recombinant HSV, KeM345, is constructed by inserting a γ34.5 gene... Agent: King & Spalding
20090117643 - Tumor-targeting gene-virus zd55-il 24,its construction method and application thereof: This present invention disclosed a tumor-targeting gene-virus ZD55-IL-24, which is a recombinant Ad5 with a deletion of E1B 55K da gene and carries the anti-tumor gene IL-24. This present invention also disclosed its construction method and its application in cancer gene-therapy. The tumor-targeting gene-virus ZD55-IL-24 of this invention can be... Agent: Zhen Zheng Lu
20090117645 - Biochips and methods of fabricating the same: Biochips for analyzing components of a biological sample using probes and methods of fabricating the same are provided. In some embodiments, a biochip includes a substrate, a plurality of probes immobilized on a top surface of the substrate, and a capping layer formed on a bottom surface of the substrate.... Agent: Mills & Onello LLP
20090117646 - Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed: A device and kit for pulsing a biological sample with a pulsing agent is disclosed. The biological sample so pulsed is subsequently stabilized and the device or kit provides a control reaction. Applications for the described device and kit are found in the field of medical diagnostics, particularly immunology.... Agent: Knobbe Martens Olson & Bear LLP
20090117647 - Method for on-line optimization of a fed-batch fermentation unit to maximize the product yield: A method for on-line optimization of fed-batch fermentation unit containing bacteria and nutrients is disclosed. Parameters of the fermenter model used in optimization calculations are estimated periodically to reduce the mismatch between the plant and the calculated values. The updated fermenter model is used to calculate the optimum sugar feed... Agent: Buchanan, Ingersoll & Rooney PC
20090117648 - Vessel and method of manufacture thereof: The invention concerns a novel sample tube and a method of manufacturing a such a sample tube. According to the method an oversized mould cavity is formed with an opposing pair of mould members of an injection moulding machine, the mould members being movable relative to each other and between... Agent: Birch Stewart Kolasch & Birch
20090117649 - Isolated soluble corticotropin releasing factor receptor type 2 (scrfr2): The present invention is directed to compositions and methods related to soluble G-protein coupled receptors (sGPCR). In certain aspects the invention includes compositions and methods related to a soluble corticotropin releasing factor receptor related protein, sCRFR2, as well as its effects on CRFR signaling and interaction between CRF family ligand... Agent: Fulbright & Jaworski, L.L.P.
20090117650 - Modified green fluorescent proteins and methods for using same: The present invention provides nucleic acid molecules encoding mutant fluorescent proteins as well as proteins encoded by these nucleic acids. In addition, host-cells, stable cell lines and transgenic organisms comprising the above-referenced nucleic acid molecules are provided. The subject protein and nucleic acid compositions find use in a variety of... Agent: Patterson & Sheridan, L.L.P.
20090117651 - Nucleoside compounds and methods of use thereof: The present invention provides methods of utilizing a nucleoside derivative having the chemical formula of Formula (I) to downregulate expression of an anti-apoptotic protein such as survivin in a cell, induce apoptosis in a cell, inhibit angiogenesis in a cell, inhibit binding of p53 to DNA in a cell, inhibit... Agent: Larry S. Millstein Holland & Knight LLP
20090117652 - Use of cxcl6 chemokine in the prevention or repair of cartilage defects: The present invention disclosed the expression of CXCL6 by cells which are able to form stable cartilage. The invention describes the use of these cells and of CXCL6 to promote cartilage (and underlying bone) formation e.g. in the repair of cartilage or osteochondral defects. The invention further describes the use... Agent: Clark & Elbing LLP
20090117653 - Method and apparatus for evaluating therapeutics on cancer stem cells: Embodiments provide cell culture methods to produce a 3-D model assembly that mimics in vitro the microenvironment of human bone marrow, where cells occupy distinct niches. Methods and apparatuses are provided for the efficient testing of cancer, including malignant hematopoietic cancers and metastatic spread to the bone marrow of solid... Agent: Schwabe, Williamson & Wyatt, P.C. Pacwest Center, Suite 1900
20090117654 - Medium for culturing hematopoietic cells and a method of culturing hematopoietic cells: Provided are a medium for culturing hematopoietic cells including lysyl oxidase inhibitor and a method of culturing hematopoietic cells using the medium.... Agent: Cantor Colburn, LLP
20090117655 - Culture matrix for forming a cell spheroid, and method of culturing the same: A culture method for allowing only cancer cells to grow from a cancerous organ or tissue sample removed surgically or endoscopically, forming a spheroid of cancer cells having a tissue structure and different cell stages similar to a tissue structure and cell stages in the living body, and removing the... Agent: Kirk Hahn
20090117656 - Stimuli-responsive degradable gel: c
20090117657 - Preparation for transferring nucleic acid into cell: The present invention provides a composition comprising a polysaccharide to enhance transfection of a cell with a nucleic acid. The present invention also provides a method for transfecting a cell with a nucleic acid comprising the steps of forming a polyionic complex of the nucleic acid and a polysaccharide; and... Agent: Birch Stewart Kolasch & Birch
20090117658 - Macrophage transfection method: Described are a method and a composition for transfecting monocytes, as well as use of the same for therapeutic purposes. The composition is composed of a nucleic acid component, a lysosome evading component and a digestible particle that can be phagocytized. Preferably, the monocyte is a macrophage and the digestible... Agent: Foley And Lardner LLP Suite 500Previous industry: Education and demonstration
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