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Chemistry: molecular biology and microbiology April category listing, related patent applications 04/09

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
04/30/2009 > patent applications in patent subcategories. category listing, related patent applications

20090111087 - Separation method of nucleated cells derived from bone marrow for bone formation: The present invention relates to a method for separating bone marrow-derived nucleated cells for bone formation. The method comprises: the steps of: washing bone marrow; lysing red blood cells in the bone marrow; neutralizing the bone marrow lysate; purifying nucleated cells from the neutralized bone marrow; and mixing the nucleated... Agent: Gwips Peter T. Kwon

20090111092 - Determination of hepatitis c virus genotype: The present invention provides compositions and methods for the detection and characterization of HCV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, to determine HCV genotype.... Agent: Casimir Jones, S.c.

20090111090 - Method for detecting integrated hpv dna: A method for detecting integrated HPV DNA is described herein. This method comprises obtaining first and second samples, obtaining first and second information, and detecting, based on the first and second information, the HPV DNA integrated into the genome of a cell derived from a subject. The second sample comprises... Agent: Sughrue Mion, PLLC

20090111089 - Primers and probes for detection and discrimination of types and subtypes of influenza viruses: Methods of detecting influenza, including differentiating between type and subtype are disclosed, for example to detect, type, and/or subtype an influenza infection. A sample suspected of containing a nucleic acid of an influenza virus, is screened for the presence or absence of that nucleic acid. The presence of the influenza... Agent: Klarquist Sparkman, LLP

20090111088 - Rapid assessment of upper respiratory conditions: A method for rapidly assessing upper respiratory conditions is provided. More specifically, the method involves contacting a sample obtained from the upper respiratory tract of a host with a test strip. The test strip contains an indicator that provides a broad spectrum response in the presence of bacteria, mold, yeast,... Agent: Dority & Manning, P.A.

20090111091 - Specimen pretreatment liquid, kit for measuring virus, and method for detecting virus: The invention provides a pretreatment liquid for preparing a sample for measuring a virus included in rhinorrhea or sputum by an immunoassay method using an antibody specifically binding to the virus, comprising a protease inhibitor for inhibiting an influence of a protease to the virus, as well as a virus... Agent: Sughrue Mion, PLLC

20090111105 - Androgen-dependent 1-f-aromatase reporter gene: The present invention relates to an androgen-dependent 1-f-aromatase reporter gene and a method for the production of the 1-f-aromatase-reporter gene and use thereof in a method for identifying ligands of the androgen receptor.... Agent: Millen, White, Zelano & Branigan, P.C.

20090111101 - Automated cancer diagnostic methods using fish: In various embodiments methods for automated screening for gene amplification in biological tissue samples using an automated fluorescence microscope to analyze fluorescence in situ hybridized samples are provided. Various additional embodiments provide methods of high throughput screening for gene amplification.... Agent: Kelley Drye & Warren LLP

20090111097 - Comparative analysis of extracellular rna species: The invention provides methods for detecting tumor-associated RNA in plasma, serum, and other bodily fluids. In particular, the invention provides methods for detecting translocated gene RNA, including fusion gene RNA, in plasma or serum or other bodily fluids.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090111111 - Detection of group b streptococcus: The invention provides methods to detect group B streptococcus (GBS) in biological samples using real-time PCR. Primers and probes for the detection of GBS are provided by the invention. Articles of manufacture containing such primers and probes for detecting GBS are further provided by the invention.... Agent: Fish & Richardson P.C.

20090111117 - Device and method for detecting complex formation: The present invention provides devices and methods for measuring electrically detectable bulk properties of liquid samples. Representative electrically detectable bulk properties measurable by the devices and methods of the invention include resistivity (conductivity) and dielectric constant (permittivity). The electrically detectable bulk properties are determined by comparing the experimental electrical output... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20090111109 - Genes relating to gastric cancer metastasis: The disclosure provides polynucleotides and polypeptides associated with gastric cancer cells, particularly those having a tendency to metastasize. Also provided are methods and kits for detecting, diagnosing, and/or monitoring metastatic gastric cancer cells.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090111118 - Method for a rapid antibody-based analysis of platelet populations: A method for identifying a platelet population, preferably a population of immature, reticulated platelets, in a biological sample involves incubating the biological sample for less than minutes with at least one labeled, ligand (e.g., monoclonal antibody) that binds to an epitope or antigen on platelets and with a nucleic acid... Agent: Howson & Howson LLP / Beckman Coulter, Inc.

20090111103 - Method for measuring the number of oral lactobacillus, and a pcr primers-probe set used for the same: There is provided a real-time PCR assay capable of measuring the number of lactobacillus present in an oral cavity, in a short time. The object can be solved by a method for measuring the number of oral lactobacillus using a combination of a forward primer comprising a oligonucleotide part of... Agent: Heslin Rothenberg Farley & Mesiti PC

20090111104 - Method for monitoring hydrolytic activity: The present invention relates to methods of measuring the activity of a hydrolytic agent comprising contacting a biomolecule with a hydrolytic agent in the presence of a fluorescent dye under conditions that allow digestion of the biomolecule by the hydrolytic agent. The fluorescence of the dye is monitored over time... Agent: Edwards Angell Palmer & Dodge LLP

20090111116 - Method for monitoring the efficacy of a mycobacterium avium subspecies paratuberculosis therapy: The present invention relates to Mycobacterium avium subspecies paratuberculosis (MAP) as the etiological agent of IBD, including ulcerative colitis and Crohn's disease, as well as Multiple Sclerosis and Alzheimer's Disease. As such, methods for monitoring efficacy of a anti-MAP therapy and determining whether a blood sample is suitable for transfusion... Agent: Licata & Tyrrell P.C.

20090111108 - Method of detecting genetic mutations: The present invention relates, in general, to drug resistance, and, in particular, to a method of detecting drug resistance populations, including minor drug resistance viral populations.... Agent: Nixon & Vanderhye, PC

20090111110 - Method of diagnosing adolescent idiopathic scoliosis and related syndromes causing spinal deformities and method for screening for a compound useful in the treatment of any of these diseases: A method for diagnosing an increased risk for a disease characterized by a dysfunctional melatonin-signaling pathway in an animal comprising detecting the presence or absence of at least one impairment in melatonin-signaling pathway in at least one of the animal's cells, wherein the presence of at least one impairment in... Agent: Goudreau Gage Dubuc

20090111096 - Method of exhaustive analysis of transcriptionally-active domain (non-methylated domain) on genome: The present invention relates to a method for the detection of a non-methylated region in genome comprising preparing the DNA fragment population consisting only of DNA fragments derived from the non-methylated regions with use of a methylation-sensitive enzyme for at least either of the first restriction enzyme X and the... Agent: Birch Stewart Kolasch & Birch

20090111093 - Methods and compositions for pre-symptomatic or post-symptomatic diagnosis of alzheimer's disease and other neurodegenerative disorders: Methods, compositions and apparatus (e.g., test kits, test systems, reagents, related computer software, calculators, etc.) for pre-symptomatic or post-symptomatic diagnosis of Alzheimer's Disease or other disorders associated with the formation of β-amyloid deposits (e.g., plaques) and/or β-amyloid fibrils. Also, methods, compositions and apparatus assessing the efficacy of treatments for such... Agent: Stout, Uxa, Buyan & Mullins LLP

20090111102 - Methods for detecting inflammatory bowel disease: The present invention provides for a method of detecting the presence of inflammatory bowel disease in gastrointestinal tissues or cells of a mammal by detecting increased expression of LY6 genes in the tissues or cells of the mammal relative to a control.... Agent: Goodwin Procter LLP

20090111094 - Methods for preparing hybrid substrates comprising dna and antibodies and uses thereof: The invention provides substrates that have antibodies and aptamers bound thereto. The invention also provides methods of detecting target analytes in a sample comprising detecting binding of a target analyte to capture probes on a substrate, wherein some of the capture probes comprise antibodies and other capture probes comprise aptamers,... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090111120 - Methylation of genes as a predictor of polyp formation and recurrence: The present invention provides methods for identifying or assessing probabilities for developing an abnormal condition in subject and for the recurrence of the abnormal condition in the subject after receiving treatment. The method comprises determining the methylation status of at least one gene in the subject and comparing this methylation... Agent: Sughrue Mion, PLLC

20090111100 - Minor groove binder - energy transfer oligonucleotides and methods for their use: The incorporation of a minor groove binder spaced close to one member of a matched FRET set in a minor groove binder-oligonucleotide conjugate significantly reduces background fluorescence of a FRET probe or pair of probes and, consequently, increases the S/B ratios. Fluorescent-labeled probes are useful in carrying out hybridization, multiplex... Agent: Townsend And Townsend And Crew, LLP

20090111095 - Novel diagnostic kit for malignant melanoma: The object of the present invention is to find out another tumor marker which is useful for early diagnosis of melanoma, and provide a diagnostic kit and diagnostic method for malignant melanoma using such marker. The present invention provides a diagnostic kit for malignant melanoma, which comprises an antibody against... Agent: Greenblum & Bernstein, P.L.C

20090111112 - Nucleic acid marker ladder for estimating mass: The invention relates to a nucleic acid marker ladder which is a restriction endonuclease digest, wherein a nucleic acid restriction endonuclease digest is a collection of nucleic acid fragments resulting from complete digestion of one or more nucleic acids by one or more restriction endonucleases; the restriction endonuclease digest contains... Agent: Invitrogen Corporation C/o Intellevate

20090111099 - Promoter detection and analysis: The present disclosure discloses an array-based method for promoter detection and analysis. Promoter sequence candidates are analyzed simultaneously in one reaction vial utilizing a vector comprising a TAG sequence wherein transcriptional products are tagged as they are synthesized, in such a way that one specific transcript is labeled with only... Agent: Pacific Intellectual Property Associates

20090111119 - Rapid in vivo identification of biologically active nucleases: Disclosed herein are methods and compositions for rapidly identifying and ranking nucleases for specific cleavage of a target sequence.... Agent: Robins & Pasternak

20090111098 - Reporter gene assay: The invention provides a more highly accurate assay for measuring the transcriptional activity of a test substance. Disclosed is a reporter gene assay, comprising the steps of contacting a cell having a vector wherein a reporter gene containing a gene encoding an epitope tag is ligated downstream to a recognition... Agent: Birch Stewart Kolasch & Birch

20090111114 - Rna extraction method, rna extraction reagent, and method for analyzing biological materials: A method to extract RNA with high purity from biological materials containing RNA in a safe, rapid, and simple procedure and a method to analyze it are provided. The procedure includes the steps of mixing a biological material containing RNA with a predetermined concentration of a chaotropic agent and a... Agent: Dickstein Shapiro LLP

20090111115 - Sequence analysis using decorated nucleic acids: The present invention provides a sequence interrogation chemistry that combines the accuracy and haplotype integrity of long-read sequencing with improved methods of preparing genomic nucleic acids and analyzing sequence information generated from those nucleic acids. The present invention encompasses compositions comprising decorated nucleic acids stretched on substrates. The present invention... Agent: Morgan, Lewis & Bockius, LLP

20090111113 - Solid support having electrostatic layer and use thereof: It is intended to provide a solid support capable of immobilizing nucleic acid molecules in a high proportion, and with a high bond strength to nucleic acid molecules. The solid support comprises a substrate and, provided thereon, an electrostatic layer for electrostatically attracting nucleic acid molecules and functional groups capable... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090111107 - Tumor suppressor gene p33ing2: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.... Agent: Townsend And Townsend And Crew, LLP

20090111106 - Vector system: The present invention provides a vector system comprising a mutated post-transcriptional regulatory element. In particular, the present invention relates to a mutated WPRE sequence that can efficiently express nucleotides of interest in a retroviral vector system. The present invention also relates to methods of delivering and expressing nucleotides of interest... Agent: Frommer Lawrence & Haug

20090111121 - Method for detecting a biomarker of oxidative stress in a biological sample: A method for characterizing oxidative stress. The method includes dosing a ratio of HNE-to-DHN-protein in blood; comparing the ratio of HNE-to-DHN-protein in blood to a predetermined interval of ratio values associated with a predetermined level of oxidative stress; and classifying the oxidative stress as having reached the predetermined level if... Agent: Louis Tessier

20090111122 - Method for non-invasive examination of non-alcoholic steatohepatitis by quantification of cytochrome-c, and test kit: It is found that blood cytochrome c levels quantified for non-alcoholic steatohepatitis patients are higher than those for healthy persons, and that the quantified blood cytochrome c values correlated with fat deposition rates in hepatocytes. It is possible to test non-alcoholic steatohepatitis by quantifying cytochrome c in serum. A test... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090111123 - Compositions for detecting antibodies to babesia microti and methods of uses thereof: The present invention relates to one or more peptides which may be used to test for the presence of antibodies to B. microti. These peptide are selected based on the strength and specificity of the human antibody response to B. microti. These peptides alone or in combination have a variety... Agent: Paul D. Yasger Abbott Laboratories

20090111126 - Mammalian cell-based immunoglobulin display libraries: Disclosed are mammalian cell surface display vectors for isolating and/or characterizing immunoglobulins and various uses thereof.... Agent: Townsend And Townsend And Crew LLP

20090111125 - Method for detecting mycobacterial infection: A method of detecting a surrogate marker for active tuberculosis involves obtaining first, second and third samples from a subject suspected of having active tuberculosis, diluting the first sample and exposing part of it to an immobilized mycolic acid antigen in a test vessel and part of it to an... Agent: Robins & Pasternak

20090111127 - Surface receptor complexes as biomarkers: The invention is directed to a new class of biomarker in patient samples comprising dimers of cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of... Agent: Monogram/fenwick

20090111128 - Method for predicting immune response to neoplastic disease based on mrna expression profile in neoplastic cells and stimulated leukocytes: Tumor necrosis factor (TNF) is capable of inducing apoptosis by interacting with specific TNF receptors on the surface of cancer cells. Because multiple members of TNF ligand and receptor are present within each superfamily, over 300 different ligand-receptor combinations exist. Activated blood leukocytes produce TNF as part of the immune... Agent: Knobbe Martens Olson & Bear LLP

20090111129 - Methods and kits for detecting fungal infection: Methods and kits which utilize a conjugate, preferably an adduct, of ergosterol for determining the presence or level of a broad spectrum of ergosterol-containing organisms (e.g., fungi) in various substrates are disclosed. These methods and kits can be used to accurately and efficiently diagnose a subject having a fungal infection,... Agent: Martin D. Moynihan Prtsi

20090111124 - Kinase peptides and antibodies: The invention relates to novel kinase peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and monitoring of the progression of a kinase-mediated disease, as well as for determining or monitoring the efficacy of treatment.... Agent: Nuclea Biomarkers, LLC

20090111131 - Method of detecting protein losing enteropathy in animals: The present invention provides a method and kit for the detection of Protein Losing Enteropathy (PLE) in animals. The method includes the steps of (a) obtaining a biological sample from an animal to be tested and (b) determining the absence or presence of albumin in the biological sample via a... Agent: Morgan, Lewis & Bockius LLP

20090111130 - Method of examining pregnancy toxemia: It is intended to provide a method of detecting the onset of pregnancy toxemia whereby the onset risk of pregnancy toxemia can be adequately evaluated. Namely, a method of detecting the onset of pregnancy toxemia in a pregnant mammal which comprises the measurement step of measuring the concentration of angiopoietin-2... Agent: Alston & Bird LLP

20090111132 - Diagnosis method of hepatic steatosis using biochemical markers: The present invention is drawn to a new diagnosis method for detecting the extent of hepatic steatosis in a patient, in particular in a patient who suffers from a disease involving hepatic steatosis, or who already had a positive diagnosis test of liver fibrosis and/or presence of liver necroinflammatory lesions,... Agent: Foley And Lardner LLP Suite 500

20090111133 - Gel filtration standard: A gel filtration standard suitable for use as molecular weight markers for gel filtration chromatography for a mobile phase with denaturant. In one embodiment, the gel filtration standard comprises ovalbumin, myoglobin, and vitamin B12. In another embodiment, the gel filtration standard comprises phosphorylase b, ovalbumin, and myoglobin along with a... Agent: Paul D. Yasger Abbott Laboratories

20090111135 - Method and apparatus for diagnoses of hemangiosarcoma in mammals: The disclosure relates to a method for detecting hemangiosarcoma in canines. The method includes the steps of: (1) obtaining a quantity of blood from the subject canine; (2) separating the quantity of blood into a serum portion and a non-serum portion; (3) contacting the serum portion of the blood with... Agent: Snell & Wilmer LLP (oc)

20090111136 - Method for detection, determination or prediction of hepatic disorder: The invention relates to a method for examining a hepatic disorder (e.g., NASH), which is less invasive and highly sensitive and which can be performed in a simple manner. According to the method, the level of a mitochondrion-derived protein (e.g., ornithine carbamoyltransferase or glutamate dehydrogenase) of a blood sample from... Agent: Bell, Boyd & Lloyd, LLP

20090111134 - Multiplex pcr assay for identification of usa300 and usa400 community-associated methicillin resistant staphylococcal aureus strains: The present invention relates to multiplex polymerase chain reaction (PCR) assays for Staphylococcus aureus typing. In particular, the invention relates to identification, detection and classification of USA300 and USA400 strains, the predominant community-associated methicillin-resistant S. aureus (MRSA) strains in North America, as well as other strains, and simultaneous detection of... Agent: Fulbright & Jaworski L.L.P.

20090111137 - Simultaneous detection of metabolic enzyme activity and metabolite levels: Provided are methods for detecting a metabolic disorder in an individual using mass spectrometry. One method involves (a) contacting a sample containing (i) one or more metabolically indicative enzymes and (ii) one or more metabolic analytes, with one or more substrates for said one or more enzymes to produce a... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

20090111139 - Diagnostic technique for determining oncogenic signature indicative of tumorous growth: A priori knowledge is obtained from known tumor samples, indicative of cellular pathways associated with those known tumor samples. Multiple pathways are found for each tumor. This becomes a priori knowledge. Later unknown tumor samples are then analyzed against the a priori knowledge to find the pathways etc within the... Agent: Law Office Of Scott C Harris Inc

20090111138 - Means and methods for the differentiation of cardiac and pulmonary causes of shortness of breath: The present invention relates to a method for differentiating in a subject suffering from chronic shortness of breath (dyspnea) between (i) a pulmonary disease, (ii) a cardiovascular complication, (iii) a cardiovascular complication accompanied by a pulmonary disease and (iv) dyspnea without cardiovascular or pulmonary causes. The method comprises the steps... Agent: Dinsmore & Shohl, LLP One Dayton Centre

20090111140 - Systems and methods for cell measurement utilizing ultrashort t2*: The present disclosure is directed to a new technique for MR measurement of ultrashort T2* relaxation utilizing spin-echo acquisition. The ultrashort T2* relaxometry can be used for the quantification of highly concentrated iron labeled cells in cell trafficking and therapy. In an exemplary embodiment, a signal is induced by a... Agent: Philips Intellectual Property & Standards

20090111141 - Method and device for studying floating, living cells: Disclosed is a method of studying floating living cell by confining the cells floating in an aqueous medium in picowells located on a bottom surface of a top wall of a chamber. Disclosed is also a picowell-bearing device for the study of cells comprising a chamber having at least one... Agent: Martin D. Moynihan Prtsi

20090111142 - Method for manufacturing a recombinant polyclonal protein: The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a collection of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090111143 - Methods and compositions for mammalian cell lines for transfection and protein expression in serum-free medium: Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene,... Agent: Immunomedics, Inc.

20090111145 - Production of hetero-oligomeric proteins in plants: Process of producing in a plant, in plant tissue, or in plant cells a hetero-oligomeric protein comprising at least a first and a second protein subunit, said process comprising expressing in plant cells at least said first and said second protein subunit by (i) providing to said plant, said plant... Agent: Alston & Bird LLP

20090111144 - Transactivation system for mammalian cells: The present invention is directed generally to compositions and methods for expressing recombinant proteins in a mammalian host cell using a co-expressed transcriptional activator. In particular, the invention provides vectors, host cells, and methods of expressing at least one desired polypeptide by transfecting a mammalian host cell with cistrons encoding... Agent: Mcdermott Will & Emery LLP

20090111146 - Antibody drug: Means for effectively performing therapies at a low cost is provided in which an antibody drug including a fusion protein fusing an extracellular region of IL-10 receptor 1 with a human antibody is used. A gene encoding a fusion protein fusing an extracellular region of IL-10 receptor 1 with a... Agent: Birch Stewart Kolasch & Birch

20090111147 - Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have... Agent: Wilson Sonsini Goodrich & Rosati

20090111148 - Immobilized microbial nitrilase for production of glycolic acid: The present invention is directed to a process for improving the specific activity of a dehydrated enzyme catalyst having nitrilase activity for hydrolysis of glycolonitrile to glycolic acid upon rehydration. In particular, a process is provided comprising pretreating an enzyme catalyst having nitrilase activity with glutaraldehyde, immobilizing the gutaraldehyde-preteated enzyme... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090111149 - Method of reducing cross-contamination in continuous amplification reactions in a channel: The present invention relates to a method for reducing cross-contamination in continuous amplification reactions in channels of microfluidic devices. More specifically, the present invention relates to the use of specific materials continuously flowing in the channels to reduce adsorption of MgCl2 and the concomitant adsorption of nucleic acid template to... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090111150 - Method for producing beta-hydroxy amino acid and enzyme used therefor: A method for producing β-hydroxy amino acid and its optically-active isomer is provided. The β-hydroxy amino acid is produced by reacting a predetermined D-α-amino acid and 5,10-methylene tetrahydrofolic acid in the presence of an enzyme derived from a microorganism belonging to the genera Paracoccus, Aminobacter, or Ensifer.... Agent: Cermak & Kenealy LLP Acs LLC

20090111151 - Production of polyketides: Recombinant host cells of the suborder Cystobacterineae containing recombinant expression vectors that encode heterologous PKS genes can produce polyketides synthesized by the PKS enzymes encoded on those vectors at high levels.... Agent: Fox Rothschild LLP Bristol-myers Squibb

20090111152 - Macrocyclization of compounds from solid support using thioesterases: A method of preparing macrocycles using solid support chemistry and thioesterases is disclosed. Also disclosed are novel macrocycles.... Agent: Marshall, Gerstein & Borun LLP

20090111153 - Method for acyltransferase reaction using acyl coenzyme a: The present invention relates to a method for acyltransferase reaction in which an acyl group of acyl coenzyme A is transferred to an acyl group receptor characterized in that the reaction is carried out by production and/or reproduction of acyl coenzyme A from coenzyme A in a reaction system by... Agent: Sughrue Mion, PLLC

20090111154 - Butanol production by recombinant microorganisms: Provided are microorganisms that catalyze the synthesis of biofuels from a suitable substrate such as glucose. Also provided are methods of generating such organisms and methods of synthesizing biofuels using such organisms. Provided are microorganisms comprising non-naturally occurring metabolic pathway for the production of higher alcohols.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20090111155 - Modified xylanase exhibiting improved expression: A modified Family 11 xylanase enzyme comprising a sequence that introduces a functional consensus glycosylation site is provided. Non-limiting examples of introduced glycosylation sites include mutation of the amino acid at position 34, 131, 180, 182, or a combination thereof, to an asparagine. The indicated amino acid position in the... Agent: Fitzpatrick Cella Harper & Scinto

20090111156 - Method of feeding microbial activity controlling substance, apparatus therefor, and making use of the same, method of environmental cleanup and bioreactor: Without using any pumps and controlling devices, to control microorganism's activity by supplying an activity controlling substance which is necessitated for the microorganism activity is realized. A microbial activity controlling material 3 is filled into a vessel 4 having a sealed structure and at least a part of which is... Agent: Notaro & Michalos P.C.

20090111157 - Protein and peptide fragments from mouse telomerase reverse transcriptase: This invention provides for murine telomerase reverse transcriptase (mTERT) enzyme proteins and nucleic acids, including methods for isolating and expressing these nucleic acids and proteins, which have application to the control of cell proliferation and aging, including the control of age-related diseases, such as cancer.... Agent: Townsend And Townsend And Crew LLP

20090111158 - Immobilized microbial nitrilase for production of glycolic acid: The present invention provides a process for preparing an enzyme catalyst having nitrilase activity for hydrolysis of glycolonitrile to glycolic acid with improved retention of recovered catalyst activity in consecutive batch reactions with catalyst recycle, said process comprising pretreating the enzyme catalyst with glutaraldehyde. The glutaraldehyde-pretreated enzyme catalyst has improved... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090111159 - Kits and processes for removing contaminants from nucleic acids in environmental and biological samples: The invention provides methods and compositions, e.g., kits, for removing contaminants from nucleic acids in a sample, e.g., environmental or biological samples such as soil, food, plant, animal, microorganism or water samples. The invention provides methods and compositions for isolating nucleic acids from environmental and biological samples in a scaleable... Agent: Morrison & Foerster LLP

20090111160 - Compositions comprising bowman-birk protease inhibitors and variants thereof: The present invention provides compositions and methods related to expression of protease inhibitors and variants thereof in bacterial species. The present invention further provides fusion nucleic acids, vectors, fusion polypeptides, and processes for obtaining the protease inhibitors.... Agent: Genencor International, Inc. Attention: Legal Department

20090111161 - Streptomyces protease: Certain aspects of this disclosure relate to an isolated protease, and cleaning compositions containing the same. In some embodiments, the protease may comprise an amino acid sequence that is at least 80% identical to the wild type Streptomyces 1AG3 protease. Isolated nucleic acid encoding the subject protease, recombinant nucleic acid... Agent: Kamrin T. Macknight Danisco US Inc., Genencor Division

20090111162 - Sequestration of formaldehyde to stabilize nitrilase specific activity when converting glycolonitrile to glycolic acid: A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.... Agent: Woodcock Washburn LLP

20090111163 - Thermotolerant actinomadura strain capable of degrading polyesters: A new thermotolerant Actinomadura sp., which is capable of degrading polyesters, is provided. Compositions comprising the strain for use in degrading polyesters are also provided. The invention also relates to methods for degrading polyesters by using the strain and the composition.... Agent: Ladas & Parry LLP

20090111164 - Method and plant for anaerobic treatment of effluent containing cellular materials: Disclosed are a method for the anaerobic treatment of pulp-containing waste and a fermentation plant for such products, wherein they are first of all mechanically prepared and comminuted, subsequently diluted to a predetermined dry matter content by the addition of process water or the like, and sanitized and anaerobically fermented... Agent: Boyle Fredrickson S.c.

20090111165 - Emulsification-free degumming of oil: This invention relates to an oil degumming method that is free of emulsification. This method includes the steps of treating crude oil first with immobilized phospholipase and then extracting the phospholipase-treated crude oil with pure water or an aqueous solution.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090111167 - Microbiological analysis machine: The machine for microbiological analysis of a support (6) comprises a spraying station adapted to actuate a spraying device (7) in order to emit a jet of droplets in a general spraying direction, said station comprising an actuator (47) of the device, a receptacle (52) for receiving said device (7),... Agent: Nields, Lemack & Frame, LLC

20090111166 - Microbiological analysis system: The system for microbiological analysis of a support comprises a plurality of spraying devices (7), a reader (49) of an item of identification (74) of a device, an actuator (47) of that device comprising a moveable unit (61) and a drive motor of said moveable unit (61), a control unit... Agent: Nields, Lemack & Frame, LLC

20090111168 - Biochip and method of fabrication: A biochip and method of fabricating the same are provided. The biochip can include a substrate, a capping layer pattern partially covering a top surface of the substrate, and a plurality of probes coupled to the top surface of the substrate exposed by the capping layer pattern.... Agent: Marger Johnson & Mccollom, P.C.

20090111169 - Biochip and method of fabrication: A biochip and method of fabricating the same are provided. The biochip can include a substrate, a plurality of active pads formed on the substrate, each of the plurality of active pads having a surface roughness and being patterned so as to produce photonic crystals, and a plurality of probes... Agent: Marger Johnson & Mccollom, P.C.

20090111170 - Nucleic acid processing methods, kits and devices: Biological samples containing nucleic acids, RNA and DNA, are freed from bound proteins by incubation with a chaotropic agent such as a guanidium salt, and the mixture is readied for further processing by dilution of such agent to a concentration below 0.05 M without physical isolation of RNA and DNA... Agent: Foley And Lardner LLP Suite 500

20090111171 - Lateral flow immunoassay controls: Rapid lateral flow immunoassays have an extensive history of use in both the clinical and home settings. These devices are used to test for a variety of analytes, such as drugs of abuse, hormones, proteins, urine or plasma components and the like. The present invention provides an improved procedural control... Agent: Inverness Medical Innovations / Wsgr Wilson Sonsini Goodrich & Rosati, P.C.

20090111172 - Murine calicivirus: The invention disclosed herein relates to a newly discovered murine norovirus, and compositions and methods related thereto.... Agent: Washington University-snr C/o Sonnenschein Nath & Rosenthal L.l.p

20090111174 - Biomolecule analyzing system: A biomolecule analyzing system (10) that provides an expeditious, accurate and reliable method for analyzing a biomolecule (150). The system (10) includes two substrates (12,28) each having an inner edge (14,30), an outer edge (16,32) and an inner surfaces (20,36) from where extends a multiplicity of cilia (22). To the... Agent: Albert O Cota

20090111173 - Micro-organism test apparatus and methods of using the same: A micro-organism testing apparatus comprising a multi-compartment resealable container provided with or adapted to receive a growth medium (97) in one compartment (83) and having a growth medium additive in another compartment (84, 85, 86), the compartments being separated by a barrier (95) whose removal or puncture will expose the... Agent: Young & Thompson

20090111175 - Nucleic acid encoding a novel ribonuclease having an amino acid sequence made up of the amino acid sequence of a known ribonuclease and an n-terminal leader sequence: A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in U.S. Pat. No. 6,239,257 B1 is preceded by a leader sequence.... Agent: Mark H. Jay, P.A.

20090111176 - Trehalose transporter gene and method of introducing trehalose into cells: There are provided trehalose transporter gene and a method of introducing trehalose into cells by using the gene. Candidates for the trehalose transporter genes were searched in P. vanderplanki EST, resulting in being obtained cDNA designated as Tret1. Tret1 encodes a 504 amino acid protein with 12 trans-membrane structures. Tret1... Agent: Kubotera & Associates, LLC Suite 202

20090111177 - Maintenance of embryonic stem cells by the gsk-3 inhibitor 6-bromoindirubin-3'-oxime: The present invention relates to methods for maintaining the undifferentiated state of embryonic stem cells without the use of a feeder layer by activating the Wnt signal transduction pathway or by inhibiting glycogen synthase kinase-3 activity by contacting the cell with, inter alia, 6-bromoindirubin-3′-oxime. The present invention also relates to... Agent: King & Spalding

20090111178 - Gene reporter assay, kit, and cells for determining the presence and/or the level of a molecule that activates signal transduction activity of a cell surface protein: The present invention relates to a commercializable cell and to a gene reporter assay method and a kit which use this cell to determine the presence and/or the level of a molecule that activates signal transduction activity of a cell surface protein. This cell is treated in such a manner... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090111179 - Cell culture shaking device and shaking culture method as cell culture method: The invention intends to provide a cell culture shaking device which is able to improve the efficiency of cell culture while preventing the cells from becoming damaged. The shaking devices used in cell culture apparatuses for culturing cells in flexible culture bags for storing culture suspension having cells inoculated therein... Agent: Frishauf, Holtz, Goodman & Chick, PC

20090111180 - Bioreactor system for three-dimensional tissue stimulator: A bioreactor system for growing and conditioning tissue for research and implantation in a human or animal body is disclosed which includes one or more tissue growth chambers for growing and conditioning tissue, each chamber being defined by a housing and providing a fluid culture media cavity which can act... Agent: Nikolai & Mersereau, P.A.

20090111181 - Apparatus for preparing a biocompatible matrix: An apparatus and method of using the apparatus to prepare a biocompatible biodegradable matrix capable of supporting cells to form an implantable or engraftable surgical device. A matrix-forming fluid is contained within a chamber defined by top and bottom surfaces of a thermally conductive material and spacers defining the thickness... Agent: Thompson Hine L.L.P. Intellectual Property Group

20090111182 - Method for propagation of plant: A novel method is provided, which makes it possible to perform mass propagation of a plant of the family Araceae, the family Bromeliaceae, or the family Marantaceae. Specifically, a method for producing an embryogenic callus, comprising culturing a leaf sheath or a part thereof of a plant selected from the... Agent: Foley And Lardner LLP Suite 500

20090111184 - Chromosome selection: Systems, methods, compositions and apparatus relating to genome, chromosome, and mitochondria selection are disclosed.... Agent: Searete LLC Clarence T. Tegreene

20090111185 - Female genome selection: Systems, methods, compositions and apparatus relating to genome, chromosome, and mitochondria selection are disclosed.... Agent: Searete LLC Clarence T. Tegreene

20090111183 - Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex: This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090111187 - Moss expressing promotion regions: Disclosed are isolated nucleic acid molecules encoding wild type nucleus derived moss expression promoting regions (MEPRs) as well as a method for producing recombinant polypeptides using such MEPRs.... Agent: Fulbright & Jaworski L.L.P.

20090111188 - Optimized non-canonical zinc finger proteins: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.... Agent: Robins & Pasternak

20090111186 - Promoter and vectors for plant transformation and methods of using same: The invention is directed to a promoter, designated MuB, sequences which hybridize to same and functional fragments thereof. The regulatory element of the invention provide improved expression in plants of operably linked nucleotide sequences. Expression vectors with the regulatory element is the subject of the invention, which may further include... Agent: Patricia A. Sweeney

  
04/23/2009 > patent applications in patent subcategories. category listing, related patent applications

20090104593 - Preparation and use of basement membrane particles: A method for supporting the in vitro growth of one or more eukaryotic cell type(s), the method comprising; seeding cells of said cell type(s) onto particles comprising basement membrane or a basement membrane-like substrate, and culturing said seeded cells in vitro under conditions suitable for expansion of said seeded cells,... Agent: Nixon & Vanderhye, PC

20090104594 - Bioreactor process control system and method: A bioreactor includes a sensor linked to a model free adaptive controller or optimizer. The sensor can provide a real time measurement of a quantity that correlates with final product titer or other desired product quality attribute.... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.

20090104597 - Advanced cervical cell screening methods: Advanced cervical cancer screening methods that provide a molecular based process of detecting HPV-integration. The disclosed methods allow for a streamlined approach of conducting a Pap test and immunohistochemical test on the same slide. The disclosed methods provides an inexpensive, highly sensitive, specific, and detailed test that is easy to... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090104595 - Methods for determining the sensitivity or resistance of retrovirus isolates to therapeutic retroviral treatments based on viral protease inhibitors and diagnostic kits: A method for determining sensitivity or resistance of isolates of HIV (human immunodeficiency virus) retroviruses to chemical molecules having an inhibiting activity on a viral protease or to therapeutic treatments based on inhibitors of the viral protease, including causing cell lysis of at least one yeast by expression of the... Agent: Ip Group Of Dla Piper US LLP

20090104596 - Noninvasive measurement and identification of biomarkers in disease state: The invention is methods and related kits for diagnosing a disease state of cachexia by measuring biomarker profiles from a biological sample. Rapid measurement of early onset or progression of the disease in a subject is determined by measuring biomarker levels from the subject and optionally comparing the biomarker levels... Agent: Greenlee Winner And Sullivan P C

20090104612 - Detection of blood group genes: Disclosed herein are nucleic acid molecules which permit the accurate and direct determination of blood groups based on the presence of certain genes. A method of determining blood groups is also provided.... Agent: K&l Gates LLP

20090104605 - Diagnosis of sepsis: Methods and apparatus for predicting the development of sepsis in a subject at risk for developing sepsis are provided. Features in a biomarker profile of the subject are evaluated. The subject is likely to develop sepsis if these features satisfy a particular value set. Methods and apparatus for predicting the... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20090104602 - Diagnosis of tuberculosis: The invention provides a method of diagnosing tuberculosis (TB) in a test subject, said method comprising: (i) providing expression data of two or more markers in a subject, wherein at least two of said markers are selected from transthyretin, neopterin, C-reactive protein (CRP), serum amyloid A (SAA), serum albumin, apoliopoprotein-A1... Agent: Nixon & Vanderhye, PC

20090104617 - Diagnostic and prognostic tests: The invention provides methods for diagnosing biological states or conditions based on ratios of gene expression data from tissue samples, such as cancer tissue samples. The invention also provides sets of genes that are expressed differentially in malignant pleural mesothelioma. These sets of genes can be used to discriminate between... Agent: Wolf Greenfield & Sacks, P.C.

20090104598 - Dopamine d2 receptor gene variants: The present invention provides a method of predicting antipsychotic response to drug therapy comprising testing a sample obtained from a subject for the presence of a polymorphism in the dopamine D2 receptor gene DRD2, wherein the presence of the rs1079598T allele, the rs1125394A allele or both is predictive of the... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20090104607 - Eubacterial tmrna sequences and uses thereof: The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090104608 - Eubacterial tmrna sequences and uses thereof: The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090104601 - Genetic diagnosis using multiple sequence variant analysis: The present invention is in the field of nucleic acid-based genetic analysis. More particularly, it discloses novel insights into the overall structure of genetic variation in all living species. The structure can be revealed with the use of any data set of genetic variants from a particular locus. The invention... Agent: Howrey LLP - East

20090104599 - Genetic variant of the annexin a5 gene: The present invention relates to a nucleic acid molecule comprising an annexin A5 (ANXA5) gene regulation element which comprises at least one point mutation, whereby said at least one point mutation (substitution) is selected from the group consisting of (i) a point mutation G to A at a position which... Agent: Foley And Lardner LLP Suite 500

20090104619 - Human g-protein coupled receptors: Two human G-Protein coupled receptor polypeptides and DNA (RNA) encoding each of such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides. Also disclosed are diagnostic methods for detecting a... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20090104606 - Late gestation lung genes, fragments and uses thereof: The present invention provides a family of genes related to late gestation lung genes and fragments thereof. Embodiments of the present invention provide compositions and methods for the therapeutic treatment of disorders in the lung or other tissues. More particularly the invention provides methods for the treatment of abnormalities in... Agent: King & Spalding

20090104621 - Method for detecting a target nucleic acid sequence: A method of detecting a target nucleic acid sequence comprising providing a stem-and-loop structured nucleic acid for measurement wherein the nucleic acid comprises complementary sequence portions located at both terminals and a target sequence portion therebetween as well as a double-stranded portion formed by hybridization of the complementary sequence portions... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090104609 - Method for discrimination of metaplasias from neoplastic or preneoplastic lesions: The present invention relates to a method for discrimination of p16INK4a overexpressing metaplasias from neoplastic or preneoplastic p16INK4a overexpressing lesions by determination of the level of high risk HPV encoded gene-products such as e.g. HPV E2 and/or HPV E7 molecules in biological samples in the course of cytological testing procedures.... Agent: Fitzpatrick Cella Harper & Scinto

20090104613 - Methods and compositions relating to multiplexed genomic gain and loss assays: Compositions and methods are provided for detecting genomic DNA gain and loss. Embodiments of inventive assays include using a substrate-attached composite nucleic acid probe which specifically hybridizes to two or more genomic loci in a genomic region of a reference genome. The genomic region is characterized by a first terminus... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

20090104611 - Methods of whole genome analysis: Methods are provided for ascertaining the sequence of a genomic DNA sample by nicking the DNA sample with a restriction nicking enzyme, followed by nick translation with labeled nucleotides, such that the labeled nucleotides can be quantified and compared to a known, reference genome.... Agent: Quarles & Brady LLP

20090104600 - Mutation within the connexin 26 gene responsible for prelingual non-syndromic deafness and method of detection: A purified polynucleotide having a chain of nucleotides corresponding to a mutated sequence, which in a wild form encodes a polypeptide implicated in hereditary sensory defect, wherein said mutated purified polynucleotide presents a mutation responsible for prelingual non-syndromic deafness selected from the group consisting of a specific deletion of at... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090104615 - Phenotype prediction: Detection of epigenetic alteration, especially methylation, of a gene or a combination of genes, preferably in a perinatal tissue sample such as umbilical cord, for predicting diverse phenotypic characteristics such as propensity for obesity, altered body composition, impaired cognition, low bone mineral content, neuro-behavioural problems and altered cardiovascular structure and... Agent: Nixon & Vanderhye, PC

20090104616 - Primer set for amplifying sult1a1 gene, reagent for amplifying sult1a1 gene containing the same, and the uses thereof: A primer set for amplifying a region including sites to be detected of SULT1A1*2 and SULT1A1*3 in the SULT1A1 gene by a gene amplification method is provided, wherein the primer set can amplify the region specifically. A pair of primer set is used including a forward primer consisting of the... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090104618 - Psoriasin expression by breast epithelial cells: The invention features methods of diagnosing high grade ductal carcinoma in situ (DCIS) These methods involve measuring: (1) the level of HID-5 in a body fluid (e.g., blood or urine) of a subject suspected of having, or at risk of having, high grade DCIS; or (2) the level of HID-5... Agent: Fish & Richardson P.C.

20090104614 - Quantitative molecular probes: In accordance with this invention, a molecular probe for detection of a nucleic acid target containing a preselected target sequence is constructed and has at least two sources of a signal: a conventional reporter source and a reference source in a form of a luminescent material, e.g., a fluorophore, quantum... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20090104610 - Real-time multiplex detection of three bacterial species responsible for sexually transmitted diseases: The invention relates to the detection of three different bacterial species which are responsible for sexually-transmitted diseases, i.e., Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Mycoplasma genitalium (MG). The invention more particularly relates to the detection of these three species in real-time PCR, in multiplex PCR and in real-time multiplex... Agent: Nixon & Vanderhye, PC

20090104620 - Simplified method of determining predisposition to scoliosis: The present invention relates to novel genetic markers associated with scoliosis, risk of developing scoliosis and risk of scoliosis curve progression, and simplified methods and materials for determining whether a human subject has scoliosis, is at risk of developing scoliosis or is at risk of scoliosis curve progression.... Agent: Michael R. Schramm Axial Biotech, Inc.

20090104604 - Sperm-specific cation channel, catsper2, and uses therefor: Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper2) are disclosed. The CatSper2 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper2 gene and protein are disclosed. Also provided are methods... Agent: Wilmerhale/boston

20090104603 - Tissue carbohydrate compositions and analysis thereof: The present invention reveals novel methods for producing novel carbohydrate compositions, glycomes, from animal tissues. The tissue substrate materials can be total tissue samples and fractionated tissue parts, or artificial models of tissues such as cultivated cell lines. The invention is further directed to the compositions and compositions produced by... Agent: Birch Stewart Kolasch & Birch

20090104623 - Compositions for controlling hair growth: FP-1 is a protein that is specifically expressed in the follicular papilla of the hair follicle. The nucleic acid and amino acid sequences of FP-1, as well as antibodies that specifically bind FP-1 are provided. In addition, methods of isolating follicular papilla cells and methods of modulating hair growth are... Agent: Wilmerhale/boston

20090104622 - Extracellular/epidermal growth factor like protein: The present invention discloses an extracellular/epidermal growth factor polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include induction of DNA synthesis, stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20090104625 - Homogeneous immunoassays for multiple allergens: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably... Agent: Tips Group C/o Intellevate LLC

20090104624 - Methods and kits for detecting ita in a biological sample: Methods for detecting invasive trophoblast antigen (ITA) in biological samples comprise screening the samples for ITA using antibodies that bind to the ITA. The methods are useful to detect pregnancy, trophoblastic diseases, and Down's syndrome in fetuses of pregnant women. Some methods include screening the samples with a plurality of... Agent: Foley & Lardner LLP

20090104626 - Methods of isolating bipotent hepatic progenitor cells: A method of obtaining a mixture of cells enriched in hepatic progenitors is developed which comprises methods yielding suspensions of a mixture of cell types, and selecting those cells that are classical MHC class I antigen(s) negative and ICAM-1 antigen positive. The weak or dull expression of nonclassical MHC class... Agent: Foley And Lardner LLP Suite 500

20090104630 - Semi-quantitative immunochromatographic device and method for the determination of hiv/aids immune-status via measurement of soluble cd40 ligand/cd 154, a cd4+t cell equivalent: A semi-quantitative, immunochromatographic device for the detection of HIV/AIDS immune status CD4+ T cell equivalents, such as soluble CD40 ligand/CD 154, includes one or more support materials capable of providing lateral flow. The one or more support materials include a first area for receiving a biological sample containing a target... Agent: Bodner & O'rourke, LLP

20090104631 - Psca: prostate stem cell antigen and uses thereof: The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.... Agent: Townsend And Townsend And Crew, LLP

20090104627 - Method for determination of enzymatic activity: A novel modified polysaccharide, a solid phase to which the polysaccharide is adhered, methods for detecting N-deacetylase activity, N-sulfotransferase activity and N-deacetylase/N-sulfotransferase activity in a sample which utilizes said solid phase, and detection kits thereof.... Agent: Sughrue-265550

20090104628 - Method for quantifying phosphokinase activity on proteins: The invention involves a method for measuring phosphorylation of proteins at specific sites and, as such, is an indicator of the protein kinase activity of enzymes capable of phosphorylating those sites. The method involves the in vitro or in vivo phosphorylation of a target protein at a specific serine, threonine... Agent: Invitrogen Corporation C/o Intellevate

20090104629 - Use of biomarkers of alzheimer's disease for diagnostic tests and drug screening: The invention relates to method of diagnosing Alzheimer's disease or detecting a predisposition to Alzheimer's disease including providing a test cell sample from a subject, exposing the test cell sample to labeled amyloid beta peptides, and determining the level of labeled amyloid beta peptides in the test cell sample, wherein... Agent: Knobbe Martens Olson & Bear LLP

20090104633 - Kit for highly sensitive detection assays: The present invention relates to kits comprising 2,4-dichlorophenoxyacetate derivatives as well as antibodies that bind to these derivatives. Inter alia, the kits can be used to label biomolecules for analytical and diagnostic applications. Some of the compounds described here can be used to label biomolecules under physiological conditions and without... Agent: Nixon & Vanderhye, PC

20090104632 - Modified two-step immunoassay exhibiting increased sensitivity: The present invention relates to immunoassays for detecting or quantifying at least one analyte of interest in a test sample which exhibits improved sensitivity and/or a reduction in non-specific background compared to the immunoassay formats known in the art.... Agent: Robert Deberardine D-377/ap6a-1

20090104634 - One-step immunoassays exhibiting increased sensitivity and specificity: The present disclosure relates to immunoassays for detecting or quantifying at least one analyte of interest in a test sample which exhibits improved sensitivity and specificity compared to the immunoassay formats known in the art.... Agent: Paul D. Yasger Abbott Laboratories

20090104635 - Fluorescent dry test strip biosensor: Disclosed herein is a dry fluorescence biosensor strip for rapid detection of a target analyte present in bodily fluids. The dry fluorescence biosensor strip comprises a sample receptacle and a dry detection membrane. The sample receptacle receives a sample of one of the bodily fluids. The dry detection membrane detects... Agent: Ashok Tankha

20090104636 - Quantitative analysis of a biological sample of unknown quantity: Disclosed is a method for testing a modified specimen such as a dried blood spot, plasma or serum specimen, for an analyte of interest, such as cholesterol. In accordance with the disclosed subject matter, the level of the analyte of interest in the medium from which the modified specimen was... Agent: Vedder Price P.C.

20090104637 - Method and apparatus for assaying blood clotting: This invention provides an apparatus for assaying clotting activity. The apparatus includes an inlet for a blood fluid and two or more patches of material in the vessel. The material is capable of initiating a clotting pathway in a blood fluid. This invention also provides an apparatus for measuring clot... Agent: Brinks Hofer Gilson & Lione

20090104638 - Methods for building atomic models of protein molecules and determining drug candidates using mgst1: Methods for building an atomic model of a protein molecule comprising: (a) identifying a protein molecule with at least 20% sequence identity with Microsomal Glutathione Transferase 1 (MGST1) and (b) utilizing the atomic coordinates of MGST1 to obtain an atomic model of the identified protein molecule and methods for determining... Agent: Porter Wright Morris & Arthur, LLP Intellectual Property Group

20090104639 - Biomarkers for motor neuron disease: The invention provides methods of determining a diagnosis or prognosis of motor neuron disease in a mammal comprising determining the expression level of one or more proteins or polypeptides of the renin-angiotensin system in a sample taken from a subject. Similarly, aberrant post-translational modification of the proteins or polypeptides as... Agent: Leydig Voit & Mayer, Ltd

20090104646 - Antibodies and methods for generating genetically altered antibodies with enhanced effector function: Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and animal varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of... Agent: Woodcock Washburn LLP

20090104643 - Bioluminescence-based sensor with centrifugal separation and enhanced light collection: In general, embodiments of the present invention relate to a bioluminescence-based point of care device that is made up of at least one reaction well (89) that contains a bioluminescent reagent for a luminescent reaction, sample well (80), sample collection well (84), and reagent well (87). A sample is introduced... Agent: Workman Nydegger 1000 Eagle Gate Tower

20090104641 - Electrochemical method for detecting hemoglobin or hematocrit and test strip thereof: The present invention provides an electrochemical method and a test strip for detecting hemoglobin in a specimen. The method includes the steps of providing the specimen with a reagent, which has a buffer solution, a surfactant and an electron mediator, tetrathiafulvalene, modified by cyclodextrin; detecting electric current produced by the... Agent: Birch Stewart Kolasch & Birch

20090104644 - Genetically modified cyclic-nucleotide controlled ion chan: A genetically modified cyclic-nucleotide controlled ion channels where the subunits thereof are altered in such a manner that they have a higher sensitivity for cAMP in relation to cGMP in comparison with the Wildtype according to Seq ID No. 1 and 2.... Agent: K.f. Ross P.C.

20090104650 - Infectious diseases testing of menstrual fluid, endometrial/menstrual cells, amniotic fluid, umbilical cord blood or other samples: Methods are provided for obtaining and testing or analyzing a non-venous and non-arterial puncture human fluid or cell sample or human body fluid or cell sample to detect the presence of at least one infectious disease. The sample may be menstrual fluid, endometrial menstrual cells, umbilical cord blood, or amniotic... Agent: Dilworth Paxson LLP

20090104649 - Markers for preeclampsia: This document provides methods and materials related to determining whether or not a pregnant mammal (e.g., a pregnant human) has preeclampsia. For example, methods and materials related to the use of urinary podocytes to determine whether or not a pregnant human has preeclampsia are provided.... Agent: Fish & Richardson P.C.

20090104640 - Method of evaluating biological material and bioreactor therefor: A method of evaluating biological material comprising forming a 3-dimensional scaffold of tubular biological material, delivering a fluid through the tubular biological material, and evaluating the biological material and in particular evaluating the effect of biomolecules, medical devices and medical devices containing biomolecules on biological material. The invention further relates... Agent: Foley & Lardner LLP

20090104647 - Methods for selecting active agents for cancer treatment: The present invention provides methods for individualizing chemotherapy, and particularly methods for individualizing neoadjuvant chemotherapy. The present invention provides methods for predicting a cancer patient's response to neoadjuvant chemotherapy, including assessing the probability of a positive response upon treatment with candidate agents prior to surgery. In various aspects, the invention... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090104642 - Novel ubiquitin ligases as therapeutic targets: The present invention relates to the discovery and characterization of activity of Fbp1, a substrate-targeting ubiquitin ligase subunit. The invention encompasses interactions between Fbp1 and its substrates, including Fbp5, β-Catenin, and IκBα. The invention also encompasses interactions between the Fbp1 isoform β-Trcp2 and its substrates, including Fbp5, b-Catenin, and IκBα.... Agent: Jones Day

20090104648 - Transformed cell with enhanced sensitivity to antifungal compound and use thereof: The present invention provides a transformed cell in which a polynucleotide having a nucleotide sequence encoding an amino acid sequence of an osmosensing histidine kinase having no transmembrane region is introduced in a functional form into a cell deficient in at least one hybrid-sensor kinase, a method of assaying the... Agent: Sughrue Mion, PLLC

20090104645 - Vectors and methods for identifying proteins amenable to crystallization: The present invention provides for methods, systems and materials that may be used to identify and select proteins that are amenable to crystallization. While previous methods of screening proteins for crystallization required at least microgram quantities of purified protein, the inventive method can be practiced using nanogram quantities of unpurified... Agent: Bryan Cave LLP

20090104651 - Screening process for antibacterial agents: The present invention relates to a method of preparing a phenotypically antibiotic-resistant subpopulation of stationary phase bacteria by treating stationary phase bacteria with high doses of antibacterial agents, the subpopulation thus identified, a process for identifying new antibacterial agents by testing against the antibiotic-resistant subpopulation, the compounds thus identified and... Agent: Sughrue Mion, PLLC

20090104652 - Method and apparatus for viable and nonviable prokaryotic and eukaryotic cell quantitation: A rapid method for the quantitation of various live cell types is described. This new cell fluorescence method correlates with other methods of enumerating cells such as the standard plate count, the methylene blue method and the slide viability technique. The method is particularly useful in several applications such as:... Agent: Seed Intellectual Property Law Group PLLC

20090104653 - Bio-process model predictions from optical loss measurements: This invention relates to methods for monitoring and controlling bioprocesses. Specifically, it describes using quasi-real-time analytical and numerical techniques to analyze optical loss measurements calibrated to indicate cell viability, whereby it is possible to reveal process changes and/or process events such as feeding or induction. Additionally, the present invention makes... Agent: Herbert Burkard

20090104654 - Low volatility high temperature tissue conditioning cross-reference to related application: Solutions exhibiting little or no evaporative loss at elevated temperatures, i.e., in excess of 100° C., are employed in place of conventional aqueous-based antigen retrieval solutions.... Agent: Hayes Soloway P.C.

20090104655 - Fermentation method and apparatus for its implementation: In order to develop and optimize metering strategies for fed-batch fermentations in two or more reaction vessels, release systems containing nutrients are attached to the inner surfaces of the reaction vessels in areas that will come into contact with culture liquid placed in the vessels.... Agent: Cohen, Pontani, Lieberman & Pavane LLP

20090104658 - Heterologous production of capreomycin and generation of new capreomycin derivatives through metabolic engineering: Provided are nucleic acid molecules comprising at least a functional fragment of the capreomycin biosynthetic gene cluster, polypeptides encoded by the cluster and recombinant host cells transformed with any of the nucleic acid molecules disclosed herein. Various methods using any of the vectors or expression cassettes that encode one or... Agent: Greenlee Winner And Sullivan P C

20090104657 - Lipase production method: The invention relates to novel proteins, especially with protease activity, which promote the production of extracellular lipases by bacteria, especially of the genus Burkholderia, nucleic acid sequences encoding them, expression constructs containing them, hosts transformed with them, methods for the production of the proteins with protease activity and methods for... Agent: Connolly Bove Lodge & Hutz, LLP

20090104659 - Novel aldolase and production process of 4-hydroxy-l-isoleucine: A novel aldolase is described. 4-hydroxy-3-methyl-2-keto-pentanoic acid, which is useful as an intermediate in the synthesis of 4-hydroxy-L-isoleucine, may be synthesized from acetaldehyde and α-ketobutyric acid using a novel aldolase, which is derived from the genus Arthrobacter.... Agent: Cermak & Kenealy LLP Acs LLC

20090104656 - System for the inducible expression of recombinant proteins in cyanobacteria: The invention relates to a system for inducible expression in cyanobacteria, which enables the expression of recombinant proteins, and to the vectors and cyanobacteria containing said expression system.... Agent: Fulbright & Jaworski L.L.P.

20090104664 - Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells: The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a mammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090104660 - Expression vector for secreting antibody fragment using e. coli signal sequence and method for mass-producing antibody fragment: A recombinant expression vector capable of expressing and secreting an antibody fragment fused with E. coli thermostable enterotoxin signal sequence derivative or E. coli outer membrane protein A (Omp A) signal sequence in the form of a soluble heterozygote protein is used to mass-produce the antibody fragment by culturing a... Agent: Sughrue Mion, PLLC

20090104661 - Human coagulation factor vii polypeptides: The present invention relates to novel human coagulation Factor VIIa variants having coagulant activity as well as polynucleotide constructs encoding such variants, vectors and host cells comprising and expressing the polynucleotide, pharmaceutical compositions, uses and methods of treatment.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20090104662 - Use of interleukin-4 antagonists and compositions thereof: Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 antagonist to a patient afflicted with such a condition. Suitable IL-4 antagonists include, but are not limited to, IL-4 receptors (such as a soluble human IL-4 receptor), antibodies that bind IL-4, antibodies that bind IL-4R, IL-4 muteins that... Agent: Immunex Corporation Law Department

20090104663 - Novel hydrophobin fusion products, production and use thereof: t

20090104665 - Purine-derived substance-producing bacterium and a method for producing a purine-derived substance: A purine-derived substance is produced by culturing a bacterium belonging to the genus Bacillus which is able to produce purine-derived substance and has been modified so that enzymatic activity of fructose bisphosphatase is decreased, and collecting the purine-derived substance from the medium or cells.... Agent: Cermak & Kenealy LLP Acs LLC

20090104666 - Hybrid glycosylated products and their production and use: The present invention relates to hybrid glycosylated products, and in particular, to natural products such as polyketides and glycopeptides, and to processes for their preparation. The invention is particularly concerned with recombinant cells in which a cloned microbial glycosyltransferase can be conveniently screened for its ability to generate specific glycosylated... Agent: Dann, Dorfman, Herrell & Skillman

20090104667 - L-amino acid-producing microorganism and a method for producing an l-amino acid: An L-amino acid is produced by culturing a microorganism which belongs to the family Enterobacteriaceae and is able to produce an L-amino acid, wherein the bacterium has been modified to enhance orotate phosphoribosyltransferase activity is enhanced, in a medium to produce and cause accumulation of an L-amino acid in the... Agent: Cermak & Kenealy LLP Acs LLC

20090104668 - Method for producing biopterins using tetrahydrobiopterin biosynthesis enzyme: Biopterins are useful compounds utilized in pharmaceutical agents or functional foods. The presence of sepiapterin reductase (SPR) involved in the biosynthesis of biopterins has not been confirmed so far in microorganisms except for a few microorganisms such as blue-green algae. For efficiently producing biopterins using microorganisms, it has been demanded... Agent: Birch Stewart Kolasch & Birch

20090104669 - Method for preparing (s)-3-hydroxy-gamma-butyrolactone using hydrolase: The present invention relates to a method for preparing S-HGB ((S)-3-hydroxy-γ-butyrolactone) using hydrolase, and more particularly to a method for preparing S-HGB in a high purity by hydrolyzing S-BBL ((S)-β-benzoyloxy-γ-butyrolactone) in the presence of hydrolase. According to the present invention, the S-HGB having an optical purity can be obtained in... Agent: Mckenna Long & Aldridge LLP

20090104670 - N-carbobenzyloxy (n-cbz)-deprotecting enzyme and uses therefor: This invention relates to isolated or recombinant N-carbobenzyloxy-deprotecting enzyme polypeptides that catalyze the removal of carbobenzyloxy from carbobenzyloxy-protected amino acids and alcohols. Also related are isolated nucleic acids encoding N-carbobenzyloxy-deprotecting enzyme polypeptides thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods... Agent: Louis J. Wille Bristol-myers Squibb Company

20090104671 - Method for producing optically active 2-(n-substituted aminomethyl)-3-hydroxybutyric acid ester: The present invention relates to a method for producing optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid esters wherein a 2-(N-substituted aminomethyl)-3-oxobutyric acid ester is treated with an enzyme source capable of stereoselectively reducing said ester to the corresponding optically active 2-(N-substituted aminomethyl)-3-hydroxybutyric acid ester having the (2S,3R) configuration. The present invention provides... Agent: Connolly Bove Lodge & Hutz LLP

20090104672 - Novel microbe, lipid modifying agent, process for producing 2-acyl-lysophospholipid, process for producing diacylglycerol, process for producing ceramide, and method of degumming oil or fat: A novel microorganism is provided, which belongs to Moritella species and is capable of producing enzymes provided with: phospholipase A1 activity; phospholipase C activity; lysophospholipase C activity; and sphingomyelinase activity. By use of those enzymes, the following processes may be effected: hydrolysis of phospholipids for production of 2-acyl lysophospholipid and... Agent: Oliff & Berridge, PLC

20090104674 - Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms: Acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, genes encoding diacylglycerol acyltransferase (DGAT1) have been isolated from Y. lipolytica and Mortierella alpina. These genes encode enzymes that participate in the terminal step in oil... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090104673 - Process for producing triglycerides: A process for producing triglycerides comprises: (a) subjecting a first triglyceride comprising at least 40% by moles of oleic acid residues, based on total acyl groups in the triglyceride, to a reaction with stearic acid, at least one ester of stearic acid or a mixture thereof, to obtain a composition... Agent: Morgan Lewis & Bockius LLP

20090104675 - Method for producing lactic acid: It has been found that the optical purity of lactic acid is reduced as the racemization reaction of lactic acid proceeds when lactic acid coexists with glycerol. By reducing the amount of glycerol prior to concentrating lactic acid by heating, the optical purity of lactic acid after concentration by heating... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090104676 - Process to sequence bioreactor modules for serial gas flow and uniform gas velocity: This invention is a process for managing the gas flow through a plurality of bioconversion modules that provide a gas liquid interface. The conversion modules provide the gas liquid interface across an activated surface that converts at least some of the gas components into desired liquid products. Arrangement of the... Agent: Cardinal Law Group

20090104677 - Heteroaromatic selective inhibitors of neuronal nitric oxide synthase: Compounds inhibiting neuronal nitric oxide synthase (nNOS) for potential treatment in neurodegenerative diseases, such as stroke, Alzheimer's disease, Parkinson's disease, Huntington's disease, such compounds of a formula.... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator

20090104678 - Method of producing polysaccharide derivatives: m

20090104679 - Crystallographic structure of mnk-1 and mnk-2 proteins: The present invention relates to crystalline Mnk-1 and Mnk-2 kinases and, in particular, to the crystal structure of Mnk-1 and Mnk-2 kinase domain.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20090104680 - Lipase powder, methods for producing the same and use thereof: A lipase powder which is a granulated substance containing a lipase and a solid content of animal milk, a lipase composition wherein said lipase powder is immersed or impregnated in fatty oil, and a method for producing the lipase powder which comprises the step of adding animal milk or cream... Agent: Buchanan, Ingersoll & Rooney PC

20090104681 - Polypeptides having alpha-amylase and granular starch hydrolyzing activity: The present invention relates to a polypeptide having alpha-amylase activity obtained from a strain of Aspergillus niger.... Agent: Genencor International, Inc. Attention: Legal Department

20090104682 - Construction of novel strains containing minimizing genome by tn5-coupled cre/loxp excision system: Disclosed is a method for developing novel strains deleted specific chromosome sites, using transposon and Cre/loxP site-specific recombination by Cre expression vector, wherein the transposon comprises a selectable marker and loxP site. The method comprises the steps of: (1) preparing a transposon comprising a selectable marker and loxP site; (2)... Agent: Howrey LLP - East

20090104683 - L-tyrosine-producing bacterium and a method for producing l-tyrosine: The present invention describes the production of L-tyrosine by culturing in a medium an Escherichia bacterium which has L-tyrosine-producing ability and which carries a mutant prephenate dehydrogenase which is desensitized to feedback inhibition by L-tyrosine, producing and accumulating L-tyrosine in the medium or in the bacterial cells, and collecting L-tyrosine... Agent: Cermak & Kenealy LLP Acs LLC

20090104684 - Diagnosis of carcinomas: The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4a polypeptides, including HE4a that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding HE4a, and also... Agent: Seed Intellectual Property Law Group PLLC

20090104685 - Reducing insoluble deposit formation in ethanol production: The present inventors have surprisingly discovered that phytic acid tenaciously precipitates with soluble metals in food or fuel ethanol-processing fluid, producing insoluble organometallic salt deposit or scale on the processing equipment that must be removed in order to facilitate further ethanol processing. The present invention relates to converting phytic acid... Agent: Merchant & Gould PC

20090104686 - Apparatus for thin-layer cell smear preparation and in-situ hybridization: The present invention discloses an apparatus for thin-layer cell smear preparation and in-situ hybridization, comprising at least one positioning device and a sealing device. The positioning device comprises at least one first opening. When the positioning device is set on a carrier device, the wall of the first opening and... Agent: Wpat, PC

20090104687 - Microbiological analysis system: The microbiological analysis system comprises a support (6) adapted to retain microorganisms in the neighborhood of a planar surface (24), said support (6) belonging to a predetermined type with which is associated a specific arrangement criterion, and an analysis machine comprising a magnetron, a microwave cavity (100) linked to said... Agent: Nields, Lemack & Frame, LLC

20090104688 - Microbiological analysis machine: The machine for microbiological analysis of a support comprises an enclosure (5, 100) adapted to receive said support (6), a window (40) for passage of said support (6) and a cover (18) for obturating said window (40), an air inlet aperture (157), an air evacuation flue (159) communicating with said... Agent: Nields, Lemack & Frame, LLC

20090104690 - Device for detecting an enzyme in a sample: A device for detecting a mammalian host-derived enzyme in a sample of a wound fluid, said device comprising: a housing having an inlet for the sample and side walls defining a fluid flow path extending from said inlet an indicator moiety that is bound to a solid substrate by means... Agent: Philip S. Johnson Johnson & Johnson

20090104689 - Microchip for use in cytometry, velocimetry and cell sorting using polyelectrolytic salt bridges: The present invention relates to a microchip using polyelectrolyte salt bridge for cytometry, velocimetry, and cell sorting. The microchip comprises; a) an inlet for solution to be analyzed, b) a microchannel which provides a moving passage for solution to be analyzed, c) at least one outlet for solution to be... Agent: Hoffmann & Baron, LLP

20090104691 - Novel recombinant adenovirus vector having a reduced side effect: The present invention provides a novel adenovirus vector for which inflammation during the in vivo administration thereof is alleviated by inhibiting the induction of expression of an adenovirus gene by a foreign promoter inserted into the adenovirus genome, and a method for producing the vector, a cell line for use... Agent: Sughrue Mion, PLLC

20090104692 - Tissue container for molecular and histology diagnostics incorporating a breakable membrane: A container for storing a biological sample for molecular diagnostic testing and/or histological testing is provided. The container includes a first chamber for receiving a sample holder therein, a second chamber, and a closure for enclosing the container. A breakable membrane, such as a piercable foil, extends within the container... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20090104693 - Udp-galactose:beta-dgalactose-r4-alpha-d-galactosyltransferase, alpha4gal-t1: A novel gene defining a novel enzyme UDP-galactose: β-D-galactose-R 4-α-D-galactosyltransferase, termed α4Gal-T1, with unique enzymatic properties is disclosed. The invention provides isolated DNA molecules and DNA constructs encoding α4Gal-T1 and derivatives thereof by way of amino acid deletion, substitution or insertion exhibiting α4Gal-T1 activity, as well as cloning and expression... Agent: Darby & Darby P.C.

20090104694 - Isolation and transplantation of retinal stem cells: The present invention relates to the isolation, in vitro propagation, and transplantation and integration of non-pigmented retinal stem cells derived from the neuroretina of the eye, ex vivo and in vivo.... Agent: Rissman Jobse Hendricks & Oliverio, LLP

20090104696 - Methods and compositions for feeder-free pluripotent stem cell media containing human serum: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component... Agent: Sutherland Asbill & Brennan LLP

20090104695 - Stem cells culture systems: The present invention concerns systems and methods for providing human cell cultures. Specific embodiments of the invention relate to cultures of feeder cells for use in stem cell technology, as well as cultures, culture systems and methods for maintenance and propagating of stem cells in an undifferentiated state as well... Agent: The Nath Law Group

20090104697 - Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells: An improved method of producing differentiated progenitor cells comprising obtaining inner cell mass cells from a blastocyst and inducing differentiation of the inner cell mass cells to produce differentiated progenitor cells. The differentiated progenitor cells may be transfected such that there is an addition, deletion or alteration of a desired... Agent: Ropes & Gray LLP

20090104698 - Bioreactor system and method for the production and collection of blood cells from engineered bone marrow tissue: Methods and apparatus for a bioreactor system for growing cells are provided. The bioreactor system includes a reaction chamber for cultivating harvested tissue in a culture medium, and a hydrodynamic apparatus connected to the reaction chamber that generates a cyclic negative pressure differential in the bioreactor. Additionally, the apparatus includes... Agent: Fenwick & West LLP

20090104699 - Container system for tissue stabilization for molecular and histopathology diagnostics: A system for storing a biological sample for transfer between two different environments is provided. The system includes a first container defining a first container interior, and a second container defining a second container interior. A first closure is provided for enclosing the open end of the first container, with... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20090104700 - Methods for transferring molecular substances into plant cells: Provided are methods for introducing a molecule of interest into a plant cell comprising a cell wall. Methods are provided for genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall.... Agent: Traskbritt, P.C./dow Agrosciences

20090104701 - Method for the production of biomass from plant differentiated tissue: The present invention provides a method and a culture medium for the production of food biomass by directly culturing seed kernel tissue, or seed cotyledonary differentiated tissue. The culture medium of the present invention contains at least DKW culture medium, Vitamin MS culture medium with an enriched concentration of thiamine,... Agent: John J. Martinez Md. Jd.

20090104702 - Attenuated chimeric flavivirus bearing attenuated japanese encephalitis virus gene as backbone: A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090104703 - Nucleic acids encoding proteins involved in sensory transduction: The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific polypeptides, antibodies to such polypeptides, methods of detecting such nucleic acids and polypeptides, and methods of screening for modulators of sensory cell specific polypeptides.... Agent: Townsend And Townsend And Crew, LLP

  
04/16/2009 > patent applications in patent subcategories. category listing, related patent applications

20090098527 - Biological organism identification product and methods: A biological organism identification product, and methods of using the same, that include a collection device to collect one or more sample organisms, a fixing and transporting composition present in an amount sufficient to kill the sample organism(s) associated with the collection device, an extraction member to extract a sufficient... Agent: Haynes And Boone, LLPIPSection

20090098530 - Cell line for producing coronaviruses: The invention relates to the production of coronaviruses. In particular, the invention relates to methods for producing SARS-CoV by using cells expressing a functional SARS-CoV receptor... Agent: Trask Britt

20090098531 - Detecting hepatitis b virus: This invention is related to methods for detecting hepatitis B virus by determining the level of hepatitis B virus surface antigen protein. This invention is also related to methods for detecting mutant hepatitis B virus surface antigen protein and kits for detecting hepatitis B virus.... Agent: Paul D. Yasger Abbott Laboratories

20090098528 - Method for determining early hcv seroconversion: The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.... Agent: Fulbright & Jaworski, LLP

20090098529 - Methods for attenuating virus strains for diagnostic and therapeutic uses: Modified or attenuated viruses and methods for preparing the modified viruses and modulating attenuation are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including as anti-tumor agents. The viruses also can be used... Agent: Bell, Boyd & Lloyd LLP

20090098532 - Probes and methods for hepatitis c virus typing using single probe analysis: This invention provides compositions and methods for HCV typing, e.g., genotyping and/or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at least five HCV genotypes (for example, selected from genotypes 1, 2, 3, 4, 5 or 6), or assign... Agent: Roche Molecular Systems, Inc. Patent Law Department

20090098537 - Biomarker for sensitivity to mtor inhibitor therapy in kidney cancer: The invention disclosed herein provides methods for the examination and/or quantification of biochemical pathways that are disregukted in pathologies such as cancer and to reagents and kits adapted for performing such methods. For example a correlation between VHL loss and mTOR inhibitor sensitivity in human kidney cancer cells is disclosed,... Agent: Gates & Cooper LLP Howard Hughes Center

20090098564 - Biomarkers for diagnosing schizophrenia and bipolar disorder: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in blood and useful in diagnosing schizophrenia and/or bipolar disorder as well as monitoring therapeutic efficacy of treatment for schizophrenia or bipolar disorder. The measurement of... Agent: Edwards Angell Palmer & Dodge LLP

20090098567 - Collection device: A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having... Agent: Gen Probe Incorporated

20090098558 - Detection, identification and differentiation of proteus species using the spacer region: c

20090098541 - Devices and processes for analysing individual cells: A device for individually analysing cells of interest, comprising (a) a channel for receiving the contents of a cell of interest, wherein the channel has an input end and an output end, and (b) a cell trapping site in proximity to the input end of the channel, wherein (i) the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090098563 - Diagnosis of (a risk of) disease and monitoring of therapy: Provided are methods for typing a sample of an individual suffering from, or at risk of suffering from, a disease and a method for monitoring treatment of an individual suffering from a disease comprising determining whether a sample from the individual comprises an expression product of AC133 in an amount... Agent: Trask Britt

20090098559 - Forensic swab and kit: The present invention relates to a high sensitivity crime scene swab device for maximal recovery of trace forensic DNA evidence left at a crime scene for DNA PCR analysis. More particularly, DNA recovery is obtained from fingerprints lifted from surfaces at the crime scene. The invention also relates to a... Agent: Kenyon & Kenyon LLP

20090098534 - Full karyotype single cell chromosome analysis: A full set of 24 chromosome-specific probes to analyze single cells or cell organelles to test for abnormalities is described. When used in an assay based on sequential hybridization, the full set is comprised of three subsets of chromosome-specific probes with each set comprised of 8 different probes. Also described... Agent: Lawrence Berkeley National Laboratory

20090098542 - Gene methylation in colon cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with colon cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of colon cancer.... Agent: Townsend And Townsend And Crew, LLP

20090098543 - Gene methylation in lung cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with lung cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of lung cancer.... Agent: Townsend And Townsend And Crew, LLP

20090098556 - Genetic test for pse-susceptible turkeys: This invention relates to methods and compounds for the improvement of turkey meat and turkey populations, but not limited to, a genetic screen to select for turkeys that produce a better quality of meat characterized by a higher postmortem pH and better water holding capacity.... Agent: Peter G. Carroll Medlen & Carroll, LLP

20090098561 - Higher-order cellular information processing devices: The invention provides various signal processing devices for integrating two or more biological signals (e.g., the presence, absence or concentration of specific ligands, etc.) to generate a status output, or a response that modulates one or more biological activities based on the status of the biological signals. The various described... Agent: Ropes & Gray LLP

20090098557 - Identification of genetic markers associated with parkinson disease: The present invention provides methods and compositions for screening a subject for Parkinson disease, for increased risk of developing Parkinson disease and/or for an earlier or later age of developing Parkinson disease, comprising detecting the presence of a genetic marker associated with Parkinson disease.... Agent: Myers Bigel Sibley & Sajovec

20090098545 - In vitro assay for identification of allergenic proteins: The present invention relates to a process for in vitro evaluation, of a potentially allergenic or tissue irritating sub-stance whereby test cells are cultivated in the presence of the substance, and the presence of up regulated genes chosen from G1P2, OASL, IFIT1, TRIM22, IFI44L, MXI, RSAD2, IFIT3, IFITM1, IFIT2, SPR,... Agent: Morrison & Foerster LLP

20090098544 - Marker molecules associated with lung tumors: The present invention relates to nucleic acids and polypeptides associated with lung cancer. The invention is more specifically related to a nucleic acids and the polypeptides transcribed thereof, the expression of which is significantly altered in association with lung cancer. The invention relates to a series of differentially spliced transcripts... Agent: Howrey LLP-ca

20090098565 - Mecp2e1 gene: The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090098554 - Method and composition for cancer diagnosis and treatment: Methods and compositions for inhibiting the onset of cancer, and cancer diagnosis and treatment are provided. The treatment method comprises inhibiting the level or function of transcriptional positive factor 4 (PC4). Also provided are methods of screening for cancer inhibition agents based on inhibition of PC4 expression or function.... Agent: Miles & Stockbridge PC

20090098536 - Method for subgroup analysis in subjects having or being suspected of having inflammatory disease, use of anti-p38mapk antibodies, kits and their use: The present invention further relates to the use of an antibody against the p38MAPK protein for determining whether a subject having or suspected of having inflammatory disease may benefit from treatment with a p38 mitogen-activated protein kinase (p38MAPK) inhibitor; kits for determining from an inflammatory tissue sample whether a subject... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090098566 - Method of synthesizing nucleic acid: The present invention relates to an oligonucleotide having a novel structure and a method of synthesizing nucleic acid by using the same as a primer. This oligonucleotide is provided at the 5′-side of the primer with a nucleotide sequence substantially the same as a region synthesized with this primer as... Agent: Nixon Peabody LLP - Patent Group

20090098555 - Methods and applications for stitched dna barcodes: Methods of identifying the genotypes of a plurality of single cells, wherein each cell includes a plurality of DNA barcodes, each associated with a genetic mutation or marker, are provided. In particular, methods including linking a plurality of DNA barcodes together to create a stitched barcode, amplifying the stitched barcode... Agent: Banner & Witcoff, Ltd.

20090098552 - Methods and compositions for analyzing ahasl genes: The invention relates to methods and compositions for analyzing plant acetohydroxy acid synthase large subunit (AHASL) genes. In particular, the invention relates to methods for the detection of wild-type AHASL alleles and mutant AHASL alleles that encode imidazolinone-tolerant AHASL proteins. The methods involve the use of PCR amplification and novel... Agent: Alston & Bird LLP Basf Corporation

20090098539 - Methods and kits for detecting an enzyme capable of modifying a nucleic acid: An improved method of detecting an enzyme in a sample, which enzyme is capable of adding or removing a chemical moiety to or from a nucleic acid molecule, thereby conferring the nucleic acid molecule with the ability to be extended to generate a novel detectable nucleic acid molecule, comprises the... Agent: Lucas & Mercanti, LLP

20090098533 - Methods and kits for investigating cancer: The invention provides novel compositions, methods and uses, for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia and breast cancer. The invention further relates to genes that are differentially expressed in breast tissue of breast cancer patients versus those of normal “healthy” tissue. Differentially expressed genes for the... Agent: Siemens Corporation Intellectual Property Department

20090098551 - Methods and products related to genotyping and dna analysis: The invention encompasses methods and products related to genotyping. The method of genotyping of the invention is based on the use of single nucleotide polymorphisms (SNPs) to perform high throughput genome scans. The high throughput method can be performed by hybridizing SNP allele-specific oligonucleotides and a reduced complexity genome (RCG).... Agent: Wolf Greenfield & Sacks, P.C.

20090098547 - Methods for identifying dna copy number changes using hidden markov model based estimations: Methods for estimating genomic copy number and loss of heterozygosity using Hidden Markov Model based estimation are disclosed.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20090098562 - Methods for identifying stem cells based on nuclear morphotypes: Methods for identifying stem cells and other cells specific to embryogenesis and carcinogenesis, classifying tissue samples, diagnosing precancerous and cancerous or atherosclerotic lesions, testing the value of anticancer agents, discovering macromolecules specifically expressed in particular cell types, using stem cells in restorative tissue therapy as well as methods for preparing... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090098546 - Methods of screening for ltrpc7 modulators: The present invention relates to the identification and isolation of a novel family of ATP regulated calcium transmembrane channel polypeptides designated herein as “LTRPC7” (Long Transient Receptor Potential Channel). Channels comprising these polypeptides close in response to concentrations of cytoplasmic ATP in the millimolar range, are subject to inhibition by... Agent: Morgan, Lewis & Bockius, LLP

20090098548 - Modulators of enzymatic nucleic acid elements mobilization: The present invention discloses a nucleic acid cleavage assay for members of the transposase/integrase superfamily. A method of using the assay to screen for modulators of the nucleic acid cleavage activity is also disclosed. The present invention further provides a method for screening for modulators of binding of a transposase/integrase... Agent: Quarles & Brady LLP

20090098550 - Mri contrast agents and high-throughput screening by mri: The present invention provides an MRI contrast agent, comprising: MRI contrast agent particles, and oligonucleotides, attached to the particles.... Agent: Evan Law Group LLC

20090098538 - Prognostic and diagnostic method for disease therapy: The present invention provides novel methods and kits for diagnosing the presence of cancer within a patient, and for determining whether a subject who has cancer is susceptible to different types of treatment regimens. The cancers to be tested include, but are not limited to, prostate, breast, lung, gastric, ovarian,... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090098560 - Purification method and kits: A method for separating nucleic acid from a liquid sample, said method comprising the steps of causing a liquid sample containing or suspected of containing said nucleic acid to flow along a bibulous membrane, for example of a conventional lateral flow device, so that nucleic acid is distributed along the... Agent: Nixon & Vanderhye, PC

20090098540 - Recirculating microfluidic device and methods of use: The present invention relates to a microfluidic test device for detecting or quantifying an analyte in a test sample. The device includes a non-absorbent substrate having at least one microchannel imbedded in the substrate, a non-specific capture device, and one or more stationary mixing structures extending into the at least... Agent: Nixon Peabody LLP - Patent Group

20090098549 - Selex and photoselex: The present disclosure describes improved SELEX methods for generating nucleic acid ligands that are capable of binding to target molecules and improved photoSELEX methods for generating photoreactive nucleic acid ligands that are capable of both binding and covalently crosslinking to target molecules. The disclosure further describes nucleic acid libraries having... Agent: Swanson & Bratschun, L.L.C.

20090098535 - Upregulation of rack-1 in melanoma and its use as a marker: The present invention concerns a method for diagnosing a melanoma in a mammal comprising the detection of the overexpression of RACK-1 protein in a melanocytic cell of said mammal, and the deduction of the presence of a melanoma from the overexpression of RACK-1 protein. The invention is also directed to... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090098553 - Urine gene expression ratios for detection of cancer: This invention relates to methods for determining the presence of cancer in a subject based on the analysis of the expression levels of an under-expressed tumour marker (TM) and at least one other TM. Specifically, this invention relates to the determination of a cancer, particularly bladder cancer, by performing ratio,... Agent: Borson Law Group, PC

20090098572 - Breast cancer resistance protein (bcrp) and antibodies thereto: The present invention provides a breast cancer resistance polynucleotide and protein of Macaca mulata (rhesus monkey) and uses thereof. The present invention also provides anti-BCRP antibodies and uses thereof, particularly as a hematopoietic stem cell marker.... Agent: Millen, White, Zelano & Branigan, P.C.

20090098570 - Lxr ligand testing method: A method of easily measuring whether or not an LXR ligand has the function of effecting, e.g., increasing, plasma triglyceride concentration and/or LDL cholesterol concentration in a mammal by using the binding activity between LXR and a coactivator, and a method of identifying LXR ligands that do not have the... Agent: Frishauf, Holtz, Goodman & Chick, PC

20090098568 - Method for immobilizing proteins: This invention provides a method for immobilizing proteins comprising: step 1 of purifying target proteins to be immobilized, which have a first tag portion and a second tag portion, with the use of the first tag portion; step 2 of activating reactive groups capable of covalently binding to the proteins... Agent: Birch Stewart Kolasch & Birch

20090098571 - Methods and substances for the diagnosis and therapy of sepsis and sepsis-like systemic infections: Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biormarkers in the diagnosis of sepsis.... Agent: Millen, White, Zelano & Branigan, P.C.

20090098569 - Novel pgc-1 isoforms and uses therefor: The invention provides isolated nucleic acid molecules, designated PGC-1b and PGC-1c nucleic acid molecules, which encode novel isoforms of PGC-1 family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20090098574 - Functionalization of gold nanoparticles with oriented proteins, application to the high-density labelling of cell membranes: The present invention relates to nanoparticles the surface of which is modified by deposition of proteins. The invention further relates to a method for producing said nanoparticles and to their use in biological research and in the biomedical field (for example labelling and diagnosis).... Agent: Foley And Lardner LLP Suite 500

20090098573 - Nucleic acids and proteins of insect or83b odorant receptor genes and uses thereof: The present invention relates to insect odorant receptor genes and methods for identifying odorant receptor genes. The invention provides nucleotide sequences of insect odorant receptor genes Or83b, amino acid sequences of their encoded proteins (including peptides or polypeptides), and related products and methods. The nucleic acids of the invention may... Agent: Fulbright & Jaworski, LLP

20090098579 - Human t1r2 polypeptide functional assays: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department

20090098580 - Mammalian sweet taste receptors: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of... Agent: Fenwick & West LLP

20090098581 - Tyrosine phosphorylation sites: The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Simona Levi-minzi, Ph.d. General Counsel

20090098576 - Feline pancreatic lipase: Isolated nucleic acid molecules having a nucleotide sequence encoding feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Isolated feline pancreatic lipase polypeptides, splice variants, allelic variants, and fragments thereof. Host cells comprising a vector containing the polynucleotide sequences and methods for expressing the polypeptides. The generation of... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090098577 - Method of identifying compounds that modulate caspase 9 activity via use of a kosmotropic salt: The present invention discloses methods for activating Caspase 9 in such a way that it can be used in assays to discover modulators of Caspase 9.... Agent: Wyeth Patent Law Group

20090098575 - The human e3alpha ubiquitin ligase family: The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3α ubiquitin ligase. The invention also relates to vector, host cells, antibodies and recombinant methods for producing the polypeptide. In addition, the invention discloses therapeutic, diagnostic and research utilities for these... Agent: Marshall, Gerstein & Borun LLP

20090098582 - Method for determining risk of cancer relapse and computer program product: The invention provides a method for determining a risk of cancer relapse comprising a step of determining the risk of cancer relapse on the basis of a comprehensive activity value of a transmembrane tyrosine kinase of a tumor cell, as well as a computer program product for determining a risk... Agent: Sughrue Mion, PLLC

20090098578 - Asbestos detection method, asbestos detection agent, asbestos detection kit, method for screening candidate for agent aiming at preventing or treating disease for which asbestos is causative or worsening factor: The present invention provides a prompt and easy asbestos detection method and a method for screening a candidate for an agent aiming at preventing or treating a disease for which asbestos is a causative or worsening factor. It is possible to quickly and easily detect asbestos in a sample by... Agent: Morrison & Foerster LLP

20090098584 - Biomarkers and methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators: VEGFR-2 biomarkers useful in a method for identifying and monitoring a mammal that will respond therapeutically to a method of treating cancer comprising administering an VEGFR-2 modulator, wherein the method comprises (a) exposing the mammal to the VEGFR-2 modulator and (b) measuring in the mammal the level of the at... Agent: Louis J. Wille Bristol-myers Squibb Company

20090098583 - Methods of detecting early renal disease in animals: The present invention provides a method for the detection of early renal disease in animals. The method includes the steps of (a) obtaining a sample from an animal to be tested and (b) determining the amount of albumin in the sample. An amount of albumin in the range of from... Agent: Sheridan Ross P.C.

20090098585 - Reagent kit for detecting lupus anticoagulant: A reagent kit capable of distinguishing between a blood sample containing lupus anticoagulant and blood samples from individuals having other anticoagulant diseases is disclosed. The reagent kit comprises two coagulation time reagents containing phosphatidylserine in a different phosphatidylserine content ratio to the total content of phospholipids from each other, threreby... Agent: Sughrue Mion, PLLC

20090098586 - Assay for determination of free d-galactose and/or l-arabinose: The invention provides an assay kit for the measurement of free D-galactose and/or Larabinose in a sample, the kit comprising galactose mutarotase and (3-galactose dehydrogenase. The kit may further comprise a reagent capable of hydrolysing molecules containing D-galactose and/or L-arabinose, to yield the free mono- or disaccharide so that the... Agent: Axinn, Veltrop & Harkrider LLP Attn. Michael A. Davitz

20090098587 - Method of screening for disorders of glucose metabolism: A method of screening for disorders of glucose metabolism such as impaired glucose tolerance and diabetes allows prevention, or early detection and treatment of diabetic complications such as cardiovascular disease, retinopathy, and other disorders of the major organs and systems. A mathematical algorithm evaluates the shape of a subject's glucose... Agent: Glenn Patent Group

20090098588 - Beta galactosidase donor fragments: Truncated fragments of the small fragment of β-galactosidase are provided that have low affinity for the large fragment of β-galactosidase and provide for robust signals when two fusion proteins are complexed due to the binding of the proteins to which the β-galactosidase fragments are fused. The truncated fragments do not... Agent: Peters Verny , L.L.P.

20090098589 - Method: There is provided a method for the detection of phytase activity in a sample, which comprises bringing into association a phytase substrate and said sample, and measuring the level of an organic metabolite of said phytase substrate.... Agent: Steptoe & Johnson LLP

20090098590 - Endotoxin analysis: The present invention relates to a method for detecting the presence or non-presence of an endotoxin, characterized in that an OmpT protein is brought into contact with a sample suspected of containing an endotoxin and the protease activity of the OmpT protein is assayed. It also relates to a method... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090098591 - Method of correlating marker molecule concentration to a specific cell potency level in chondrocyte culture: A method for measuring the potency of tissue culture derived chondrocyte or chondrocyte-like cells by correlating levels of the marker molecules SERPINA1 and MMP3 in culture supernatant with a specific level of cell potency; including a method for analyzing chondrogenic potency in cells re-differentiated from chondrocytes losing their chondrogenic potency,... Agent: Lauson & Tarver LLP

20090098592 - Method: A method is described for releasing a soluble or membrane associated intracellular protein of interest (POI) comprising the steps of: providing a cell comprising a soluble or membrane associated intracellular POI; contacting the cell with a membrane extracting composition; and causing the POI to be released from the cell under... Agent: Frommer Lawrence & Haug

20090098593 - Laboratory plate thermal vault: A portable temperature transfer device for transferring thermal energy to and/or from a laboratory plate is provided as well as its methods of use. The temperature transfer device comprises a base and a raised stage that comprises a thermal conductive material and an encasement that interfaces with the base to... Agent: Goodwin Procter LLP Attn: Patent Administrator

20090098594 - Methods for diagnosis prognosis and methods of treatment: This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of cells present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor... Agent: Wilson, Sonsini, Goodrich & Rosati / Nodality, Inc

20090098596 - Photostable fret-competent biarsenical-tetracysteine probes based on fluorinated fluoresceins: i

20090098595 - Tumor marker for ovarian cancer diagnosis: The present invention relates to a tumor marker for diagnosis of ovarian cancer, which is selected from the group consisting of galectin-1, cathepsin B, MHC class I antigen, heat shock protein (HSP) 27, ubiquitin carboxy-termal esterase L1, plasma retinol-binding protein (PRBP), transthyretin, SH3 binding glutamate-rich protein, tubulin-specific chaperone A, RNA... Agent: Wpat, PC Intellectual Property Attorneys

20090098597 - Method for quantifying cell motility and cell migration: A method of quantifying cell migration of a cell population is provided. The method includes the step of patterning the cell population within a channel network in a first body. A first image of the cell population is obtained. Thereafter, a second image of the cell population is obtained after... Agent: Boyle Fredrickson S.c.

20090098598 - Process for intergrated utilization of the energy and material contents of hydrolysates: A process for integrated utilization of the energy and material contents of hydrolysates and solids obtained in the enzymatic hydrolysis of renewable raw materials, in which the resulting hydrolysis solution is used as a carbon source in fermentations and the unhydrolysed solids are sent to biogas production.... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20090098599 - Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use: The present invention relates to methods for gene therapy, especially to adenovirus-based gene therapy, and related cell lines and compositions. In particular, novel nucleic acid constructs and packaging cell lines are disclosed, for use in facilitating the development of high-capacity and targeted vectors. The invention also discloses a variety of... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP

20090098602 - Bacillus mhkcel cellulase: The present invention provides a novel cellulase nucleic acid sequence, designated mHKcel, and the corresponding mHKcel amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding mHKcel, recombinant mHKcel proteins and methods for producing the same.... Agent: Victoria L. Boyd Genencor International, Inc.

20090098606 - Methods for producing biological substances in pigment-deficient mutants of bacillus cells: The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent Bacillus cell under conditions conducive for the production of the heterologous biological substance, wherein (i) the mutant cell comprises a first nucleic acid sequence directing synthesis of the heterologous biological... Agent: Novozymes, Inc.

20090098605 - Mutated truncated mt-pfka gene for the synthesis of active shorter fragment of 6-phosphofructo-1-kinase: The invention deals with mutated truncated mX-pfkA gene encoding shorter fragment of 6-phosphofructo-1-kinase (PFK1), with no need for phosphorylation of the protein molecule for activation, that is not significantly inhibited by citric acid and/or its salts and ATP molecules. Active 49-52 kDa fragment encoded by mt-pfltk gene, retains positive regulatory... Agent: Smith Moore Leatherwood LLP

20090098603 - Polypeptides sharing sequence identity with a fibroblast growth factor polypeptide and nucleic acids encoding the same: The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences,... Agent: Morrison & Foerster LLP

20090098601 - Selection of host cells expressing protein at high levels: The invention provides a DNA molecule comprising an open reading frame sequence that encodes a selectable marker polypeptide, wherein said DNA molecule in the coding strand comprises a translation start sequence for the selectable marker polypeptide having a GTG startcodon or a TTG startcodon, and wherein the open reading frame... Agent: Trask Britt

20090098604 - Synthetic gene encoding human epidermal growth factor 2/neu antigen and uses thereof: Synthetic polynucleotides encoding human HER2/neu or a truncated form thereof, are provided, the synthetic polynucleotides being codon-optimized for expression in a human cellular environment. The gene encoding hHER2 is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to... Agent: Merck And Co., Inc

20090098600 - Thermotolerant ribonuclease h: Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090098607 - Production of recombinant human hemoglobin using pichia yeast: The present invention provides a production method of a functional recombinant human hemoglobin, which comprises transforming a yeast of the genus Pichia with an expression vector containing a DNA encoding a human hemoglobin α-chain (Hbα), which is under regulation of a promoter functional in a yeast of the genus Pichia,... Agent: Leydig Voit & Mayer, Ltd

20090098609 - Il-2 fusion proteins with modulated selectivity: The invention provides cytokine fusion proteins with an increased therapeutic index, and methods to increase the therapeutic index of such fusion proteins. The fusion proteins of the invention are able to bind to more than one type of cytokine receptor expressed on cells and also bind to more than one... Agent: Goodwin Procter LLP Patent Administrator

20090098608 - Methods, systems and reagents for improved immunodetection: The instant invention provides methods, systems and reagents for immunodetection involving novel epitope tags and antibodies which recognize these new epitope tags as well as the antibodies which detect the FLAG epitope tag. Fusion proteins comprising the epitope tags, as well as methods of purifying these proteins and kits detecting... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20090098610 - Polypeptides having dna polymerase activity: A polypeptide having a high fidelity DNA polymerase activity and thus being useful as a genetic engineering reagent; a gene encoding this polypeptide; a method of producing the polypeptide; and a method of amplifying a nucleic acid by using the polypeptide.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090098611 - Self-cleaving affinity tags and methods of use: The present invention relates to compositions and methods relating to development of modified inteins comprising one or more topoisomerase recognition sequences and the corresponding topoisomerase proteins and/or one or more recombination sites and the corresponding recombination proteins systems for use in affinity-based protein expression systems.... Agent: Katten Muchin Rosenman LLP

20090098613 - Method for synthesizing dna: A DNA synthesis reaction-enhancer comprising at least one kind selected from the group consisting of acidic substances and cationic complexes; a DNA synthesis method in which during a DNA synthesis reaction a reaction is carried out in the presence of the above enhancer by using DNA polymerase; a DNA synthesis... Agent: Birch Stewart Kolasch & Birch

20090098612 - Method of amplifying a target nucleic acid by rolling circle amplification: Provided is kit for and a method of amplifying a nucleic acid using rolling cyclic amplification (RCA), including amplifying a nucleic acid together with formation of a single-strand circular DNA template using RCA by reacting a reaction solution including: (a) two hairpin oligos, (b) a target nucleic acid, (c) a... Agent: Sughrue Mion, PLLC

20090098614 - Methods and compositions for controlling efficacy of rna silencing: Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining, for example, the degree of complementarity required between an RNAi-mediating agent and its target, i.e., whether mismatches are tolerated, the number... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090098615 - Genetically modified cells and methods for converting (r)-methylmalonyl coa to (s)-methylmalonyl coa: Recombinant Escherichia coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases not present in... Agent: Morrison & Foerster LLP

20090098616 - Enzymatic treatment of lignocellulosic materials: A method for treating plant materials to release fermentable sugars is disclosed. More specifically, a two-stage enzymatic hydrolysis process for treating lignocellulosic materials and producing a sugar rich process stream that may subsequently be subjected to fermentation to produce biofuels and chemicals is disclosed.... Agent: Bereskin And Parr

20090098617 - Enzymatic treatment under vacuum of lignocellulosic materials: A method for treating plant materials to release fermentable sugars is disclosed. More specifically, an enzymatic hydrolysis process for treating lignocellulosic materials performed under vacuum and producing a sugar rich process stream that may subsequently be subjected to fermentation to produce biofuels and chemicals is disclosed.... Agent: Bereskin And Parr

20090098618 - Treatment of lignocellulosic materials utilizing disc refining and enzymatic hydrolysis: A method for treating plant materials to release fermentable sugars is disclosed. More specifically, lignocellulosic materials are subjected to disc refining together with enzymatic hydrolysis to produce a sugar rich process stream that may subsequently be subjected to fermentation to produce biofuels and chemicals is disclosed.... Agent: Bereskin And Parr

20090098619 - Method of producing liquid and powered mushroom beta-glucan: A method of producing liquid and powdered mushroom Beta-Glucan provides a uniform culture medium for the mushroom growing well and yielding high beta-glucan production rate. Adapting animal cell culture techniques, the growth of mushroom mycelium is speeded up and the production time is minimized. The use of serum bottles with... Agent: David And Raymond Patent Firm

20090098620 - Production method for solid cultured active mushroom mycelium and fruit-body metabolites (amfm) products thereof: A production method effectively increases the amount and yield of mushroom beta-glucan, and widely applied in the fields of food, biotechnology, cultivation and medical development. The cultivating medium contains the nutrition of three natural grains, including brown rice, adlay and oat, to provide a complete physiological environment for the mushrooms... Agent: David And Raymond Patent Firm

20090098621 - Method for producing an l-amino acid using bacterium of the enterobacteriaceae family with attenuated expression of a gene coding for small rna: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene coding for sRNA.... Agent: Cermak & Kenealy LLP Acs LLC

20090098622 - Schizochytrium pks genes: The present invention relates to compositions and methods for preparing poly-unsaturated long chain fatty acids in plants, plant parts and plant cells, such as leaves, roots, fruits and seeds. Nucleic acid sequences and constructs encoding PKS-like genes required for the poly-unsaturated long chain fatty acid production, including the genes responsible... Agent: Sheridan Ross P.C.

20090098623 - Process for the racemization of optically active secondary alcohols with the use of alcohol dehydrogenase: A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class.... Agent: Connolly Bove Lodge & Hutz, LLP

20090098624 - Fermentation processes: The present invention provides a fermentation process for producing a fermentation product from starch-containing material wherein one or more antibacterial agents are added before and/or during fermentation.... Agent: Novozymes North America, Inc.

20090098626 - Nucleic acids encoding modified cytochrome p450 enzymes and methods of use thereof: The present invention provides nucleic acids comprising nucleotide sequences encoding modified cytochrome P450 enzymes; as well as recombinant vectors and host cells comprising the nucleic acids. The present invention further provides methods of producing a functionalized compound in a host cell genetically modified with a nucleic acid comprising nucleotide sequences... Agent: Uc Berkeley - Otl Bozicevic, Field & Francis LLP

20090098625 - System and method for sequestering carbon dioxide and biological conversion of carbon dioxide through phytogenic processing into biogas and oxygen: A method for converting carbon dioxide into various gases is disclosed. The method comprises the use of naturally-occurring methanogenic bacteria, like that contained in peat moss, to convert carbon dioxide into various gases through bioconversion utilizing phytogenic processes.... Agent: Weiss & Moy PC

20090098627 - Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20090098628 - Methods and devices for microencapsulation of cells: Devices for the microencapsulation of cells include a first chamber for containing a cell-solution suspension. A plate covers one end of the first chamber. The plate has a plurality of apertures. A second chamber is provided for receiving encapsulated cells. The second chamber is separated from the first chamber by... Agent: Myers Bigel Sibley & Sajovec

20090098629 - Novel gene expressed in prostate cancer: A novel testis-specific gene expressed in human prostate cancer, designated 22P4F11, is described. Analysis of 22P4F11 mRNA expression in normal prostate, prostate tumor xenografts, and a variety of normal tissues indicates that the expression of this gene is testis specific in normal tissues. The 22P4F11 gene is also expressed in... Agent: Agensys C/o Morrison & Foerster LLP

20090098630 - Fusion protein, gene related to fusion protein, vector, transformants, and anti-inflammatory medicinal composition: Fusion protein comprises a thioredoxin and human serum albumin. The thioredoxin comprises a protein comprising the amino acid sequence shown in SEQ. ID. No. 1, or the like, the human serum albumin comprises a protein comprising the amino acid sequence shown in SEQ. ID. No. 2, or the like. The... Agent: Sughrue Mion, PLLC

20090098631 - Novel glutamic acid decarboxylase (gad) proteins and methods of use: The invention relates to novel Glutamic Acid Decarboxylases (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, epilepsy, and the like, using viral and non-viral delivery systems that... Agent: Nutter Mcclennen & Fish LLP

20090098632 - Compositions comprising viruses and methods for concentrating virus preparations: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.... Agent: Townsend And Townsend And Crew, LLP

20090098633 - Hmgn2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells: The present invention provides a conjugate which contains a therapeutic moiety linked to a homing molecule that selectively homes to tumor blood vessels and tumor cells and that specifically binds the receptor bound by peptide KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK (SEQ ID NO: 9). Methods of directing a conjugate of the invention to tumor... Agent: Mcdermott, Will & Emery

20090098634 - Scleroprotein of an adeno associated virus with modified chromatographic properties, the production thereof and use of the same: The invention relates to a scleroprotein of an adeno-associated virus which contains at least one mutation. Said mutation causes the chromatographic properties to be modified. The invention also relates to the production of said scleroprotein and the use thereof.... Agent: Clark & Elbing LLP

20090098635 - Method for supply of starter cultures having a consistent quality: The present invention relates to the field of producing starter cultures. In particular, a method for customers in need of a starter culture with a consistent quality, is provided. Specifically, the method involves the use of subsets of a stock inoculum material, which comprises a concentrate of starter culture organism... Agent: Foley And Lardner LLP Suite 500

20090098636 - Fungal cell wall synthesis gene: A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these... Agent: Townsend And Townsend And Crew, LLP

20090098637 - Circulation of algal broth by thermally-induced convection: The present invention provides a method of circulating algae in growing containers using thermally-induced convection techniques. In particular, a method of growing algae by providing a thermal gradient in algae containing medium is disclosed.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090098638 - Increased fiber hydrolysis by protease addition: Novel fiber processing methods and the products obtained therefrom are disclosed. Methods may include thermochemical and/or enzymatic hydrolysis of fiber feedstocks including distillers' dried grains, distillers' dried grains with solubles, soyhull, miscanthus and switchgrass. Enzymatic hydrolysis includes hydrolysis with cellulase, hemicellulase, and protease.... Agent: Buchanan Ingersoll & Rooney PC (archer Daniels Midland Company)

20090098639 - Apparatus for execution of treatment operations in connection with colouring of tissue specimens on object glasses: An apparatus for automatic execution of different treatment operations in connection with staining of tissue specimens on microscope slides, wherein the apparatus (1) comprises a loading station (2) for microscope slides (7) with tissue specimens, a number of reagent stations (3) for staining of the tissue specimens on supplied microscope... Agent: Frommer Lawrence & Haug

20090098640 - Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins: A method and apparatus for embedding cells that utilizes a flow-through embedding technique maximizes the efficiency of extractions and decreases time for embedding the cell fragments, minimizes cell loss, and automatically positions cell samples at the position in which a microtome blade will section them. The apparatus includes a cell... Agent: Wolf Greenfield & Sacks, P.C.

20090098641 - Incubator humidity control: An incubator 1 for cell culture, or biological or chemical samples is provided, the incubator having disposed therein a humidity sensor 28 and a humidifier 2 having an atomiser including a spray nozzle 21. A compressed air supply line 25 and a liquid supply line 26 are connected to the... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20090098642 - Incubator: An incubator including a temperature-controlled room adjusted to a predetermined environment condition for culturing a sample of an incubation container at inside of the temperature-controlled room, the incubator including a shifting mechanism for moving a position of the incubation container at inside of the temperature-controlled room by a motor, a... Agent: Oliff & Berridge, PLC

20090098643 - Multilayer circuit devices and manufacturing methods using electroplated sacrificial structures: A multilayer circuit includes a dielectric base substrate, conductors formed on the base substrate and a vacuum deposited dielectric thin film formed over the conductors and the base substrate. The vacuum deposited dielectric thin film is patterned using sacrificial structures formed by electroplating techniques. Substrates formed in this manner enable... Agent: Foley & Lardner

20090098644 - Diagnostic test unit with a container for test carriers: The invention concerns a diagnostic test unit for analysing a body fluid comprising a test carrier (test tape 10; test strips 12) provided with test fields (38) for applying the body fluid and a container (14) containing the test carrier, wherein an opening (18) of the container (14) is at... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20090098645 - Cell culture article and methods thereof: Disclosed is a cell culture article including: a substrate; a tie-layer attached to at least the substrate; and a bio-compatible layer attached to at least the tie layer, the bio-compatible layer having been obtained from surface oxidation of a polymer layer. Also disclosed are methods for making the cell culture... Agent: Corning Incorporated

20090098646 - Staining and sticking system: The staining and sticking system is composed of a staining device and a sticking device, which is provided separately from the staining device, is capable of lightening the staining and sticking work and can be downsized. The staining and sticking system comprises the staining device 10 for staining a specimen... Agent: Birch Stewart Kolasch & Birch

20090098647 - Recombinant antigens for the detection of coxiella burnetii: The invention relates to a method for the detection of prior exposure to Coxiella burnetii infection by antibody-based assays using recombinant, immunodominant C. burnetii polypeptides. The invention also relates to the design of biotin or His-tagged C. burnetii proteins useful in the antibody-based assays as standardized antigen reagents.... Agent: Naval Medical Research Center Attn: (code 00l)

20090098648 - High-titer retroviral packaging cells: The present invention relates to non-replicative recombinant retrovirus packaging cells able to grow in suspension in a serum-free medium. In particular, the present invention relates to a human embryonic 293SF-based cell line stably expressing gag and pol gene products from the murine Moloney leukemia virus (MLV) and either the feline... Agent: Ogilvy Renault LLP

20090098649 - Newly established cell lines from maruca vitrata: The present invention relates to Maruca vitrata cell lines established from pupal tissues of M. vitrata, including NTU-MV, two subclones of NTU-MV: NTU-MV-1 and NTU-MV-2. The NTU-MV cell line was confirmed to be derived from M. vitrata, and NTU-MV-1, and NTU-MV-2 were confirmed to be derived from NTU-MV by karyotype... Agent: Wpat, PC Intellectual Property Attorneys

20090098650 - Compositions for the in vitro derivation and culture of embryonic stem (es) cell lines with germline transmission capability and for the culture of adult stem cells: The present invention describes novel compositions for deriving, maintaining and growing pluripotent and germ-line competent mammalian embryonic stem cells. The compositions of this invention refer to compositions comprising a 1) conditioned medium of a cell line expressing limited amounts of Leukemia Inhibitory Factor (LIF), 2) conditioned medium from a cell... Agent: Clark & Elbing LLP

20090098651 - Cardiomyocyte culture support: e

20090098652 - Self assembling peptide systems and methods: The present invention provides a self-assembling peptide system which utilizes a bioactive sequence which enhances transfection efficiency. In particular, the present invention provides compositions and methods for transfecting aggregates of cells at a higher efficiency.... Agent: Casimir Jones, S.c.

20090098653 - Transgenomic mitochondria, transmitochondrial cells and organisms, and methods of making and using: The invention provides transgenomic mitochondria, transmitochondrial cells and organisms, and the materials and methods for making such mitochondria, cells, and organisms.... Agent: Eugenia S. Hansen Hemingway & Hansen, LLP

20090098654 - Selectable genetic marker for use in pasteurellaceae species: The present invention provides a nucleic acid encoding nicotinamide phosphoribosyltransferase (NadV) from a V-factor independent bacterium and provides methods for using the gene as a selection marker for constructing recombinant bacteria from V-factor dependent bacteria. The method is an improvement over methods which rely on nucleic acids which confer antibiotic... Agent: Ian C. Mcleod, P.C.

  
04/09/2009 > patent applications in patent subcategories. category listing, related patent applications

20090092958 - Method of inactivating blood coagulation factor and blood coagulation factor-inactivated sample: A method of inactivating a blood coagulation factor is described. The method comprises a step of contacting a sample containing at least one of factors V and VIII with a compound having an iminodiacetate group, whereby at least one of factors V and VIII in the sample is changed into... Agent: Sughrue Mion, PLLC

20090092961 - Identification and modification of dynamical regions in proteins for alteration of enzyme catalytic effect: A method for analysis, control, and manipulation for improvement of the chemical reaction rate of a protein-mediated reaction is provided. Enzymes, which typically comprise protein molecules, are very efficient catalysts that enhance chemical reaction rates by many orders of magnitude. Enzymes are widely used for a number of functions in... Agent: Scully Scott Murphy & Presser PC

20090092960 - Novel fluorescent and colored proteins, and polynucleotides that encode these proteins: The subject invention provides new fluorescent and/or colored proteins, and polynucleotide sequences that encode these proteins. The subject invention further provides materials and methods useful for expressing these detectable proteins in biological systems.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090092959 - Nucleic acid and allergenic polypeptides encoded thereby in cashew nuts: The invention describes an isolated nucleic acid sequence comprising the nucleotide sequence of SEQ ID NO:1 or a degenerate variant of SEQ ID NO: 1. The nucleic acid sequence encodes an Ig-E binding immunogenic polypeptide the amino acid sequence of which comprises at least one sequence selected from SEQ ID... Agent: Enrique G. Estevez

20090092965 - Method and apparatus for target detection using electrode-bound viruses: A biosensor capable of detecting the presence and/or concentration of an analyte or biomarker includes at least one electrically conductive electrode operatively coupled to an impedance analyzer for measuring the change in the resistive impedance of the electrode in response to an applied alternating current at a plurality of frequencies.... Agent: VistaIPLaw Group LLP

20090092963 - Method for combined parallel agent delivery and electroporation for cell structures an use thereof: Disclosed is a method for parallel delivery of agents to and/or into a cell structure, wherein at least two electrolyte-filled tubes are provided together with a counter electrode, the tubes being connected to a voltage or current generator, said agents being introduced into the electrolyte solution contained in the tubes,... Agent: Edwards Angell Palmer & Dodge LLP

20090092962 - Method for detecting sars coronavirus: This invention provides: a method for detecting SARS pathogenic viruses with high sensitivity and rapidity for diagnosing severe acute respiratory syndrome (SARS); an oligonucleotide primer that can specifically hybridize with any nucleotide sequence constructed based on the nucleotide sequence of RNA polymerase of the SARS coronavirus; a method for nucleic... Agent: Sughrue Mion, PLLC

20090092964 - Methods for individualizing cardiovascular disease treatment protocols based on beta-1 adrenergic receptor haplotype: A method is provided for determining whether a treatment protocol for a human patient who is suffering from heart failure, ischemic heart disease, cardiac arrhythmias, or hypertension includes administration of a beta blocker, the method including obtaining a biological sample from the patient, determining a β1-adrenergic receptor (β1AR) sequence of... Agent: Dinsmore & Shohl, LLP

20090092991 - Assays, methods and systems for predicting follicular lymphoma outcome: Assays, kits, methods and systems for predicting outcome in patients with follicular lymphoma based upon measurement of one or more phenomenologically competitive or synergistic gene pairs or a set of classifier genes are provided.... Agent: Licata & Tyrrell P.C.

20090092978 - Association of uqcrc1snps with fat deposition and fatty acid composition: The present invention relates to the identification of single nucleotide polymorphisms (SNPs) in a ubiquinol-cytochrome c reductase core protein I (UQCRC1) gene and its associations association with fat deposition and fatty acid composition. The invention further encompasses methods and systems, including network-based processes, to manage the SNP data, haplotype data... Agent: Frommer Lawrence & Haug

20090092993 - Cellular arrays and methods of detecting and using genetic disorder markers: A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array, and performing a different biological analysis of each copy. The results of the different biological analyses are compared... Agent: Kevin Farrell Pierce Atwood

20090092966 - Colloidal metal aggregates and methods of use: Metal colloidal aggregates substrates useful for metal enhanced fluorescence applications, are disclosed. Method of making and using these colloidal aggregates for enhancing the fluorescent signal in biological assays are also described.... Agent: Townsend And Townsend And Crew, LLP

20090092970 - Composition and method for nucleic acid sequencing: The present invention provides compositions and methods for detecting incorporation of a labeled nucleotide triphosphate onto the growing end of a primer nucleic acid molecule. The method is used, for example, to genotype and sequence a nucleic acid. In a preferred embodiment, the method described herein detects individual NTP molecules.... Agent: Townsend And Townsend And Crew, LLP

20090092969 - Detection of atypical pneumonia: Disclosed herein are methods and compositions for detecting one or more pathogens that cause atypical pneumonia. Detectable pathogens include Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila.... Agent: Foley & Lardner LLP

20090092984 - Determining a predisposition to cancer: The present invention relates to methods and kits for determining a predisposition and surveillance protocols for developing cancer of various sites due to specific mutation in at least one allele of CHEK2 gene and/or at least one allele of NOD2 gene and/or at least one allele of CDKN2A gene.... Agent: Gary J. Gershik, Esq.

20090092986 - Fluorescent nucleobase conjugates having anionic linkers: Provided are nucleotide-dye conjugates and related compounds in which a dye is linked to a nucleobase directly or indirectly by an anionic linker. The anionic character of the linker is provided by one or more anionic moieties which are present in the linker, such as phosphate, phosphonate, sulfonate, and carboxylate... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090092973 - Grading of breast cancer: Methods and compositions for the identification of breast cancer grade signatures are provided. The signature profiles are identified based upon multiple sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for identification of cells as being in one or... Agent: Patentique PLLC

20090092976 - Hypermethylation of gata-4 and gata-5 transcription factor genes in cancer: Methods are provided for identifying the presence of cancer cells in a sample by detecting hypermethylation of the promoter region of a GATA-4 transcription factor gene, a GATA-5 transcription factor gene, or both. Methods for ameliorating a cancer by effecting expression of a hypermethylation silenced GATA-4 and/or GATA-5 transcription also... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP

20090092983 - Identification of an erbb2 gene expression signature in breast cancers: A method for analyzing differential gene expression associated with breast tumor is based on the analysis of the over-expression or under-expression of polynucleotide sequences in a biological sample. The analysis includes the detection of the over-expression of at least one polynucleotide sequence(s), subsequence(s) or complement(s) thereof selected from predefined polynucleotide... Agent: Ip Group Of Dla Piper US LLP

20090092977 - Mass spectrometric methods for detecting mutations in a target nucleic acid: Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and mutations in the molecules are provided.... Agent: Grant Anderson LLP C/o Portfolioip

20090092971 - Method for detecting p53 dysfunction, method for molecular diagnosis of cancer and method for evaluating compound effective in treating cancer: The present invention relates to methods for detecting a dysfunctional cancer suppressing gene, particularly p53. In other aspects, the invention provides methods for diagnosing cell proliferative disorders such as cancer by measuring expression of a predetermined target gene. Methods of evaluating the efficacy of a test compound to treat a... Agent: Merck And Co., Inc

20090092967 - Method for generating target nucleic acid sequences: The present invention provides methods of generating target nucleic acids for amplification using nicking enzymes and methods for amplifying the generated target nucleic acids.... Agent: Townsend And Townsend And Crew, LLP

20090092995 - Method for identifying within a mammal a dna encoding a physiologically active polypeptide: The present inventors found that a physiological effect of a particular DNA can be detected independently within mice into which a pool of various DNAs in various quantities has been introduced. This finding suggests that it is possible to identify a DNA having a particular physiological effect by successively fractionating... Agent: Fish & Richardson PC

20090092972 - Method of evaluating drug sensitivity by analyzing girk channel genes: A method of evaluating drug sensitivity or disease vulnerability, includes linking a gene polymorphism in a GIRK channel gene or a haplotype comprising the gene polymorphism to individual drug sensitivity or individual disease vulnerability.... Agent: Birch Stewart Kolasch & Birch

20090092982 - Methods and compositions for increasing biological molecule stability: The present invention relates to methods and compositions for enhancing folding and stability of biological molecules. In particular, the present invention relates to methods and compositions for identifying biological molecules with enhanced stability. The present invention further relates to host cells that confer enhanced stability to biological molecules expressed therein.... Agent: Casimir Jones, S.c.

20090092979 - Methods for isolating long fragment rna from fixed samples: The present invention relates to methods for the extraction of long fragment RNA from fixed tissue specimens. In particular, the present invention relates to methods for the extraction of RNA from formalin-fixed paraffin-embedded tissue specimens for use in biologic applications, including assays based on oligonucleotide hybridization.... Agent: Womble Carlyle Sandridge & Rice, PLLC

20090092989 - Microfluidic platforms for multi-target detection: Disclosed are example methods and devices for detecting one or more targets. An example method includes placing a sample including a first target with in a microfluidic device and hybridizing a plurality of copies of the first target with a plurality of nanostructures. The example method includes applying an electric... Agent: Hanley, Flight & Zimmerman, LLC

20090092974 - Micrornas differentially expressed in leukemia and uses thereof: The present invention concerns methods and compositions for identifying a miRNA profile for acute myeloid leukemia (AML), and using the profile in assessing the condition of a patient.... Agent: Fullbright & Jaworski L.L.P.

20090092980 - Mirna processing inhibitor efficacy assays and substances: The invention relates to assays for assessing miRNA maturation effector (preferably: inhibitor) efficacy, and to substances useful for influencing, particularly for inhibiting, maturation of miRNA. According to the invention there is provided assay of miRNA processing inhibitor efficacy, comprising the steps of: a) providing a target miRNA precursor, b) providing... Agent: Alston & Bird LLP

20090092988 - Modulating gene expression with agrna and gapmers targeting antisense transcripts: Gene expression is selectively modulated in the genome of a mammalian cell determined to be in need thereof by determining the presence of an encoded antisense transcript overlapping a promoter of the target gene; contacting the transcript with an agRNA or gapmer complementary to a portion of the transcript upstream... Agent: Richard Aron Osman

20090092992 - Novel human dickkopf-related protein and nucleic molecules and uses therefor: Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule... Agent: Amgen Inc. Law Department

20090092987 - Polymorphic nucleic acids associated with colorectal cancer and uses thereof: The present invention provides compositions and methods for research, diagnostic, drug screening, and therapeutic applications related to colorectal cancer and related conditions. In particular, the present invention provides genetic variations in or associated with one or more of the STK38L, GPR45, TGFBRAP1, PADI3, IBRDC1, and/or GRK5 genes as being associated... Agent: Casimir Jones, S.c.

20090092990 - Primers and methods for the detection and discrimination of nucleic acids: The present invention provides novel primers and methods for the detection of specific nucleic acid sequences. The primers and methods of the invention are useful in a wide variety of molecular biology applications and are particularly useful in allele specific PCR.... Agent: Invitrogen Corporation C/o Intellevate

20090092994 - Reagents, methods and kits for classification of fungi and direction of anti-fungal therapy: Provided herein are methods, kits and compositions to classify fungi. Methods are provided for classification of fungi according to established phenotypes, for example, antimicrobial susceptibility profiles. More specifically, the invention provides methods for the use of PNA probes in diagnostic applications, which will aid in the direction of appropriate therapy... Agent: Edwards Angell Palmer & Dodge LLP

20090092968 - Screening method for mycobacteria in metal removal fluid systems: One embodiment of the invention includes a method for testing a fluid for contamination by a mycobacterial organism. A plurality of individual standardized samples may be acquired from a plurality of predetermined sampling points and pooled into a pooled sample. The pooled sample may be analyzed using a polymerase chain... Agent: General Motors Corporation C/o Reising, Ethington, Barnes, Kisselle, P.C.

20090092985 - Screening tools for discovery of novel anabolic agents: The disclosure provides nucleic acids including the polynucleotide sequence of the human MAFbx core promoter involved in muscle specific expression. Also provided are reporters operably linked to a polynucleotide sequence including MAFbx transcription regulatory sequences, and constructs including polynucleotides that encode reporters and other polynucleotide sequences operably linked to the... Agent: Klarquist Sparkman, LLP

20090092975 - Selectable marker: A nucleic acid sequence encoding a decarboxylation enzyme E.G. PAD1 is used as a selectable marker in a recombinant organism. A weak acid is used as the selecting agent.... Agent: Clark & Elbing LLP

20090092981 - Tetrahydropyran nucleic acid analogs: The present disclosure describes tetrahydropyran nucleoside analogs, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, tetrahydropyran nucleoside analogs are provided, having one or more chiral substituents, that are useful for enhancing properties of oligomeric compounds including nuclease resistance and binding affinity. In some embodiments, the... Agent: Jones Day For Isis Pharmaceuticals, Inc.

20090092998 - Marker for arrhythmia risk: The present invention relates to markers and methods for determining risk of ventricular arrhythmia in an individual. By using the markers of the present invention, individual with high risk of ventricular arrhythmia can properly be detected and treated. The present inventors have discovered that IL-6 and/or DROMs have strongly positive... Agent: Blank Rome LLP

20090092999 - Methods of predicting therapeutic response in atopic dermatitis to il-31 antagonists: The present invention relates to predicting therapeutic response of treating patients suffering from itching and puritis mediated by cutaneous lymphocyte antigen positive T cells in atopic dermatitis. The invention also includes methods of predicting a therapeutically responsive patient population.... Agent: Zymogenetics, Inc. Intellectual Property Department

20090092997 - Modulators that promote cell surface expression of odorant receptors: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and... Agent: Casimir Jones, S.c.

20090092996 - Mucopolysaccharidosis (mps) diagnostic methods, systems, kits and assays associated therewith: Methods, systems, kits and assays for diagnosing, monitoring or screening for mucopolysaccharidosis (MPS) and methods and systems for assaying test compounds for therapeutic activity are described, whereby MPS marker protein levels are assayed as an indication of MPS.... Agent: Morrison & Foerster LLP

20090093000 - Glycoprotein and apolipoprotein biopolymer markers predictive of alzheimers disease: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their... Agent: Mchale & Slavin, P.A.

20090093001 - High content screening: A high content screening (HCS) assay for rapidly screening one or more compounds to determine functional response or pharmacological properties thereof, comprising: i) priming a cell or cell material with a sensor for a biological response; ii) contacting the compound(s) to be tested with the primed cell or cell material... Agent: Iplm Group, P.A.

20090093002 - Humanized antibody: The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.... Agent: Jones Day

20090093003 - Porcine umami taste receptors and uses therefor: The present invention provides nucleic acids encoding porcine taste receptors, polypeptides encoded by the nucleic acids, and methods of using the nucleic acids and polypeptides to identify compounds that enhance umami taste.... Agent: Townsend And Townsend And Crew, LLP

20090093004 - Potency assay: The present invention provides a method for determining the in vitro potency of antibodies, in particular anti-Rhesus D positive antibodies. Such antibodies may e.g. be used in the prophylaxis of hemolytic disease of the newborn (HDN), treatment of idiopathic thrombocytopenic purpura (ITP) and prevention of sensitization to the Rhesus D... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090093005 - Protein-based biomarkers for abdominal aortic aneurysm: The present invention encompasses compositions and methods useful for diagnosing subjects with abdominal aortic aneurysms. The invention relates to the use of protein biomarkers whose levels are different in subjects with abdominal aortic aneurysms relative to normal subjects.... Agent: University Of Virginia Patent Foundation

20090093006 - Core 2 beta(1,6)-acetylglycosaminyltransferase as diagnostic marker for atherosclerosis: A method of indicating the presence of the atherosclerosis (particularly coronary artery atherosclerosis) in a subject is provided, comprising comparing the level of Core 2 GlcNAc-T in a tissue sample from a subject with a reference level determined for the same tissue. A level of Core 2 GlcNAc-T in the... Agent: Nixon & Vanderhye, PC

20090093007 - Method for producing dry analytical element for pancreatic lipase measurement: It is an object of the present invention to provide a method for producing a dry analytical element for pancreatic lipase analysis in a stable manner with good accuracy, such element having high specificity with respect to pancreatic lipase and being available for convenient use. The present invention provides a... Agent: Birch Stewart Kolasch & Birch

20090093008 - Method for detection of microorganism and kit for detection of microorganism:

20090093009 - Mass spectrometry method for measuring thiamine in body fluid: Provided are methods for determining the amount of total thiamine in a body fluid sample using liquid chromatography and mass spectrometry. Total thiamine is converted to free thiamine by treatment with an acid phosphatase prior to thiamine separation and quantification.... Agent: Foley & Lardner LLP

20090093010 - Method of detecting kidney dysfunction: Methods and kits for monitoring kidney function, and detecting kidney dysfunction and transplant related disease and rejection are disclosed. The method involves analyzing a sample, such as a urine sample, containing protein from an animal for fragments of β2-microglobulin, wherein the presence of specific β2-microglobulin fragments is indicative of kidney... Agent: Patrick D. Kelly

20090093011 - Biosensors for ligand-directed functional selectivity: A system and method for determining ligand-directed functional selectivity of a receptor in a live-cell with a biosensor are disclosed. Also disclosed is a system and method for fragment-based screening with a cell-based, label-free biosensor functional assay.... Agent: Corning Incorporated

20090093014 - Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof: This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of... Agent: Edwards Angell Palmer & Dodge LLP

20090093012 - Reaction cassette for measuring the concentration of glycated hemoglobin and measuring method thereof: A reaction cassette for a glycated hemoglobin meter and a measuring method thereof are provided. The reaction cassette for the glycated hemoglobin meter includes: a first zone receiving a first reagent and a blood sample; a second zone receiving a second reagent; a reaction zone in which the blood sample... Agent: Cantor Colburn, LLP

20090093013 - Single-cell label-free assay: The disclosure provides a system and method for characterizing a single live-cell response to a stimulus with a biosensor imaging system having cells immobilized on the biosensor at a resolution level of a single cell, as defined herein.... Agent: Corning Incorporated

20090093015 - Beta-cryptoxanthin production using a novel lycopene beta-monocyclase gene: Novel lycopene beta-monocyclase genes were identified and used to transform a host cell to produce β-cryptoxanthin. The host cell produces lycopene and is transformed to express the novel lycopene β-monocyclase that converts lycopene into γ-carotene. The host cell is further transformed to express a lycopene hydroxylase that hydroxylates γ-carotene to... Agent: Davis, Brown, Koehn, Shors & Roberts, P.C. The Davis Brown Tower

20090093016 - Selective enzymatic hydrolysis of c-terminal tert-butyl esters of peptides: The present invention relates to a process for the selective enzymatic hydrolysis of C-terminal esters of peptide substrates in the synthesis of peptides, comprising hydrolysing C-terminal tert-butyl esters using the protease subtilisin. This process is useful in the production of protected or unprotected peptides.... Agent: Organon Usa, Inc. C/o Schering-plough Corporation

20090093022 - Chemosensory gene family encoding gustatory and odorant receptors and uses thereof: This invention provides an isolated nucleic acid encoding an insect gustatory or odorant receptor. This invention provides a nucleic acid of at least 12 nucleotides capable of specifically hybridizing with a nucleic acid encoding an insect gustatory or odorant receptor. This invention also provides a purified, insect gustatory or odorant... Agent: John P. White Cooper & Dunham LLP

20090093021 - Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor: Carbohydrate utilization-related and multidrug transporter nucleic acids and polypeptides, and fragments and variants thereof, are disclosed in the current invention. In addition, carbohydrate utilization-related and multidrug transporter fusion proteins, antigenic peptides, and anti-carbohydrate utilization-related and anti-multidrug transporter antibodies are encompassed. The invention also provides vectors containing a nucleic acid of... Agent: Alston & Bird LLP

20090093018 - Method of producing heterodimer derivative of protein phosphatase type 2a enzyme: The purpose of the invention is to provide an activated protein phosphatase 2A (PP2A) in large quantities with high purity by a genetic engineering and to provide a method for producing a heterodimer derivative of PP2A which comprises infecting insect cultured cells with a baculovirus in which a cDNA encoding... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090093020 - Methods for reducing or eliminating alpha-mannosidase resistant glycans in the production of glycoproteins: The present invention provides methods to reduce or eliminate α-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of α-mannosidase resistant glycans on glycoproteins results from the disruption of the newly isolated P. pastoris AMR2 gene encoding β1,2-mannosyltransferase. The present invention also discloses novel genes, polypeptides, antibodies, vectors... Agent: Merck And Co., Inc

20090093017 - Nucleic acids encoding recombinant protein a: Disclosed are new recombinant nucleic acids encoding protein A polypeptides and methods of using these nucleic acids.... Agent: Fish & Richardson PC

20090093019 - Production and in vivo assembly of soluble recombinant icosahedral virus-like particles: The present invention provides an improved method for the in vivo production of soluble assembled virus-like particles (“VLPs”) in bacterial cells of Pseudomonad origin. The Pseudomonad cells support assembly of VLPs from icosahedral viral capsid proteins (“CPs”) in vivo, and allow the inclusion of larger recombinant peptides as monomers or... Agent: Traskbritt, P.C.\dow Global Technologies Inc.

20090093023 - Elements for improved expression of bovine somatotropin: The invention allows improved expression of heterologous polypeptides such as bovine somatotropin (bST). Novel compositions and methods are provided for production of bST from a native bST cDNA in transformed host cells such as E. coli. In particular, DNA segments comprising novel ribosome binding sites and adjacent sequences are provided,... Agent: Howrey LLP

20090093024 - Methods of generating libraries and uses thereof: This invention relates to methods for the generation of polynucleotide seed libraries and the use of these libraries in generating novel mutants of recombinant proteins and, more particularly, for generating focused libraries of recombinant human antibodies and screening for their affinity binding with target antigens.... Agent: Wilson Sonsini Goodrich & Rosati

20090093026 - Transducible delivery of sirna by dsrna binding domain fusions to ptd/cpps: The disclosure provides fusion polypeptides and constructs useful in delivering anionically charged nucleic acid molecules including diagnostics and therapeutics to a cell or subject. The fusion constructs include a protein transduction domain and a nucleic acid binding domain, or a protein transduction domain and a nucleic acid that is coated... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20090093025 - Twin-arginine translocation in bacillus: Described herein are methods to enhance protein secretion in a host cell. In preferred embodiment, the host cell is a gram-positive microorganism such as a Bacillus. In another preferred embodiment, the host cell is a gram-negative microorganism. Preferably the gram-negative microorganism is an Escherichia coli or a member of the... Agent: Genencor International, Inc. Attention: Legal Department

20090093027 - Process for producing sugars and ethanol using corn stillage: A process for producing sugars from lignocellulosic materials such as corn stover by the addition of corn stillage as a carbon source is disclosed. The sugars are formed by treating the combination of the corn stillage and the lignocellulosic materials with hydrolytic enzymes. The sugars can be fermented to ethanol,... Agent: Ian C. Mcleod Ian C. Mcleod, P.C.

20090093028 - Apparatus and methods for treating biomass: An apparatus for treating plant biomass is described herein. Generally, the apparatus includes a pressurizable vessel and a heating element in thermal communication with the vessel. Also described herein are methods of treating plant biomass. Generally, the methods include heating plant biomass under conditions effective to at least partially depolymerize... Agent: Mueting, Raasch & Gebhardt, P.A.

20090093029 - Method for producing l-amino acid: An L-amino acid is produced by culturing an Enterobacteriaceae which is able to produce an L-amino acid in a medium containing glycerol, especially crude glycerol, as the carbon source to produce and accumulate the L-amino acid in the culture, and collecting the L-amino acid from the culture.... Agent: Cermak & Kenealy LLP Acs LLC

20090093030 - Fadr knock-out microorganism and methods for producing l-threonine: The present invention relates to an L-threonine-producing chromosomal fadR gene knock-out microorganism. The present invention further relates to a method for producing L-threonine using a fadR knock-out microorganism. Mutated microorganisms of the present invention are capable of increased L-threonine production.... Agent: Arent Fox LLP

20090093031 - Ketoreductase polypeptides for the production of (r)-3-hydroxythiolane: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize chiral compounds.... Agent: Dechert, LLP

20090093032 - Process for producing 7-methoxy-3-desacetylcefalotin: Process for producing 7-methoxy-3-desacetylcefalotin by a hydrolysis process which takes place in water and is catalyzed by an enzyme. Cefoxitin can be obtained from this compound by known methods.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090093033 - Pufa-pks genes from ulkenia: The invention relates to genes which are coded for sequences specific to polyketide synthases (PKS). The thus synthesized PKS is characterized by the enzymatic capacity thereof to produce PUFAs (polyunsaturated fatty acids). The invention also relates to the identification of the corresponding DNA-sequences, in addition to the use of said... Agent: Hammer & Associates, P.C.

20090093034 - Method for separation of lactic acid component from lactic acid fermentation liquor, and separation apparatus: A lactic acid component (e.g., lactic acid or oligo (lactic acid)) can be obtained by extraction from a lactic acid fermentation liquor with a pH of 4.8 or less, using at least one solvent selected from the group consisting of toluene, xylene, mesitylene, ethylbenzene, methanol, ethanol, propanol, butanol, and mineral... Agent: The Webb Law Firm, P.C.

20090093035 - Blocking sporulation by inhibiting spoiie: We have shown that the control of solventogenesis and sporulation can be genetically uncoupled in C. acetobutylicum. In strain 824(pASspo), the absence of SpoIIE causes sporulation to be blocked at stage II. The cell remains in a vegetative state, and this allows solvent production to proceed for longer and for... Agent: Baker & Mckenzie LLP

20090093036 - Method for releasing genetic material from solid phase: The present invention relates to systems for releasing genetic materials from a solid medium. The present invention also relates to methods for releasing genetic materials from a solid medium. The present invention further relates to methods for isolating genetic material from a biological sample.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090093037 - Method and apparatus for accelerating growth of lactic acid bacteria with electric field: The method and apparatus for accelerating growth of lactic acid bacteria, which apply an electric field to the lactic acid bacteria using an electric field in a frequency band of 1 kHz to 1 MHz, can be applied to all lactic acid bacteria used in home and industries to accelerate... Agent: Cantor Colburn, LLP

20090093038 - Method for the production of pure virally inactivated butyrylcholinesterase: The present invention provides a method for purifying butyrylcholinesterase from various biological fluids. Biological fluids include, e.g., blood, blood fractions, plasma, and bioreactor broths, and other such mixtures containing butyrylcholinesterase. In one embodiment, the invention provides a method for the production of purified, virally inactivated butyrylcholinesterase by contacting a biological... Agent: Buchanan, Ingersoll & Rooney PC

20090093039 - Regulatable growth of filamentous fungi: The present invention generally relates to hyphal growth in fungi and in particular describes the modulation of genes associated with hyphal growth in filamentous fungi. The present invention provides methods and systems for the production of proteins and/or chemicals from filamentous fungi which comprise modulation of genes associated with hyphal... Agent: Genencor International, Inc. Attention: Legal Department

20090093040 - Bovine immunodeficiency virus (biv) based vectors: This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter... Agent: Mdip LLC

20090093041 - Methods for drying bacteriophage and bacteriophage containing compositions, the resulting dry compositions, and methods of use: Liquid bacteriophage products may be dried to form dry bacteriophage products. Drying may be effected by pulse combustion drying processes. When dried, the number of viable bacteriophage particles is reduced by no more than about two log (102). The resulting dry bacteriophage product, therefore includes at least one percent of... Agent: Trask Britt

20090093042 - Biofilter media to remove odour causing compounds from waste gas streams: A biofilter media has one or more of a set of desired physical characteristics. The set of physical characteristics includes a sphericity of 0.75 to 1, a particle size of 1 to 16 or 4 to 8 mm, a uniformity coefficient of 2 or less and a surface area of... Agent: Bereskin And Parr

20090093043 - Thermostable nucleic acid polymerase from thermococcus gorgonarius: A purified thermostable enzyme is derived form the thermophilic archaebacterium Thermococcus gorgonarius. The enzyme can be native or recombinant, retains approximately 90% of its activity after incubation for two hours at 95° C. in the presence of stabilizing agents and possesses 3′-5′ proofreading exonuclease activity. Thermostable DNA polymerases are useful... Agent: Townsend And Townsend And Crew, LLP

20090093044 - Method for treating organic matter to promote mouldering: The present invention relates to a method for treating organic matter to promote mouldering wherein the organic material is subjected to a splitting process followed by a freeze drying process prior to being transferred for deposition for mouldering.... Agent: Gauthier & Connors, LLP

20090093045 - Organism testing apparatus: An organism testing apparatus adapted to measure the organisms in a specimen in stable fashion is disclosed in which the organisms are stained, the specimen is concentrated and the information on the organisms contained in the specimen are acquired through a simple process. The apparatus includes a staining unit for... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090093046 - Incubation apparatus: An incubation apparatus, including a temperature-controlled room adjusted to be a predetermined environment condition, and incubating a sample of an incubation container inside the temperature-controlled room, includes a carrying apparatus, an imaging section, and an image analyzing section. The carrying apparatus carries the incubation container in the temperature-controlled room. The... Agent: Oliff & Berridge, PLC

20090093047 - Kit and device for generating chemiluminescence radiation: A device for generating a chemiluminescence radiation depending on the binding of at least one ligand that is contained in a sample that is to be tested to at least one receptor that is binding-specific for the ligand has a flow cell having an internal cavity. The internal cavity has... Agent: The Webb Law Firm, P.C.

20090093049 - Methods of identifying synthetic transcriptional and translational regulatory elements, and compositions related to same: Provided are methods of identifying oligonucleotides having transcriptional or translational activity by integrating ilie oligonucleotide into a eukaryotic cell genome such that the oligonucleotide is operatively linked to an expressible polynucleotide, and detecting a change in expression of the expressible polynucleotide due to the operatively linked oligonucleotide. Also provided are... Agent: Dla Piper LLP (us)

20090093048 - Promoters and usage thereof: Promoters and usage thereof. Two promoters, acuF and hsp promoters, comprise the nucleotide sequences of SEQ ID NO: 1 and 2, respectively.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20090093050 - Dna vaccine enhancement with mhc class ii activators: Methods for treating or preventing hyperproliferating diseases, e.g., cancer, are described. A method may comprise administering to a subject in need thereof a therapeutically effective amount of a nucleic acid encoding an MHC class I and/or II activator and optionally a nucleic acid encoding an antigen.... Agent: Foley Hoag, LLP (w/jhv)

20090093051 - T1r1 nucleic acid sequences and vectors containing same: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department

20090093052 - Human hematopoietic stem and progenitor antigen and methods for its use: A hematopoietic progenitor cell antigen and reagents, notably antibodies, that specifically bind to the antigen are provided. Expression of the antigen is highly tissue specific. It is only detected on a subset of hematopoietic progenitor cells derived from human bone marrow, fetal bone marrow and liver, cord blood and adult... Agent: Townsend And Townsend And Crew, LLP

20090093053 - Cd44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases: An isolated polypeptide is provided. The isolated polypeptide comprising an antigen recognition domain capable of specifically binding a CD44 polypeptide as set forth in SEQ ID NO: 2 and incapable of binding a CD44 polypeptide selected from the group consisting of: SEQ ID NO: 4 or 6.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090093054 - Cryopreservation of human blastocyst-derived stem cells by use of a closed straw vitrification method: An improved method for vitrification of biological cells, especially blastocyst-derived stem cells (BS cells). The method is very mild for the cells that remain viable after they have been thawed. The method comprises, i) transfer of the cells to a first solution (solution A), ii) optionally incubation of the cells... Agent: Buchanan, Ingersoll & Rooney PC

20090093055 - Islet cells from human embryonic stem cells: This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High quality populations of islet cells can be produced in commercial quantities for use in research,... Agent: Geron Corporation Attn. David J. Earp

20090093056 - Adult stem cell-derived connective tissue progenitors for tissue engineering: Methods of generating and expanding proliferative, multipotent connective tissue progenitor cells from adult stem cells are provided. Also provided are methods of generating functional tendon grafts in vitro and bone, cartilage and connective tissues in vivo using the isolated cell preparation of connective tissue progenitor cells.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090093057 - Interleukin-22 polypeptides, nucleic acids encoding the same and methods for the treatment of pancreatic disorders: The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of... Agent: Goodwin Procter LLP

20090093058 - Cell transfection array for introduction of nucleic acid: The subject of the present invention is to provide a microarray for introducing nucleic acid, the microarray capable of introducing and expressing nucleic acid into cells simply by adding the nucleic acid onto a plate and the like, and then seeding the cells thereon and culturing them without adding a... Agent: Jhk Law

20090093059 - Compositions and methods to stack multiple nucleotide sequences of interest in the genome of a plant: Methods and compositions for the stacking of multiple nucleotide sequences at precise locations in the genome of a plant or plant cell are provided. Specifically, transfer cassettes comprising nucleotide sequences of interest flanked by non-identical recombination sites are introduced into a plant comprising a target site. The target site contains... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

  
04/02/2009 > patent applications in patent subcategories. category listing, related patent applications

20090087829 - Production of monatin enantiomers: Methods for preferentially hydrolyzing one stereoisomer of an isoxazoline diester over another, as well as an enzyme for facilitating the preferential hydrolysis are provided. Also provided are methods for providing mixtures of (RR) and (RS) monatin as well as (SS) and (SR) monatin, which methods can include the step of... Agent: Fish & Richardson P.C.

20090087830 - Systems and methods for harvesting, storing, and implanting hair grafts: A system and method for harvesting, storing, and implanting biological units, in particular hair follicular units (FUs). The system is particularly useful to facilitate hair transplant procedures. FUs are harvested from a body surface, either attached to a patient or in a strip of removed tissue, and shuttled into a... Agent: Restoration Robotics, Inc.

20090087833 - Adipogenic adenoviruses as a biomarker for disease: This invention relates to the relationship between infection with an adipogenic adenovirus, such as adenovirus-36, and obesity-related disease. In particular, this invention relates to assaying a subject to determine the adipogenic adenovirus infection status and then determining the subject's predisposition to developing an obesity-related disease based on the adipogenic adenovirus... Agent: Townsend And Townsend And Crew, LLP

20090087831 - Methods for evaluating a bacteriophage preparation: A quality assurance/quality control paradigm for bacteriophage is provided.... Agent: Hunton & Williams LLP Intellectual Property Department

20090087832 - Nucleic acids and new polypeptides associated with and/or overlapping with hepatitis c virus core gene products: DNA encoding core+1 polypeptides of hepatitis C virus (HCV), nucleotides encoding the polypeptides, and methods for using the nucleotides and the encoded polypeptides are disclosed.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090087838 - Analyte detection using autocatalytic chain reactions: Compositions and methods for detecting the presence of analytes employing autocatalytic chain reactions (ACR) having super linear kinetics for amplification of signal are disclosed.... Agent: Morrison & Foerster LLP

20090087840 - Combined extension and ligation for nucleic acid assembly: Certain aspects of the present invention provide methods for assembling nucleic acid molecules. Some embodiments involve analyzing nucleic acid sequences and determining appropriate assembly strategies based on the presence or absence of sequence features that are known or predicted to interfere with extension-based and/or ligation-based assembly techniques. Aspects of the... Agent: Wolf Greenfield & Sacks, P.C.

20090087847 - Determining a nucleic acid sequence imbalance: Methods, systems, and apparatus are provided for determining whether a nucleic acid sequence imbalance exists within a biological sample. One or more cutoff values for determining an imbalance of, for example, the ratio of the two sequences (or sets of sequences) are chosen. The cutoff value may be determined based... Agent: Townsend And Townsend And Crew, LLP

20090087848 - Determining segmental aneusomy in large target arrays using a computer system: A method and/or system for making determinations regarding samples from biologic sources including statistical methods for making meaning grouping of observed data and/or for pre-selecting endpoints.... Agent: Quine Intellectual Property Law Group, P.C.

20090087845 - Genetic markers of true low birth weight: The present application provides for a method of diagnosing TLBW via measurement of expression of various TLBW-related genes. The present application also provides kits for the diagnosis of TLBW in a subject. The present application also provides a method for determining the basis for appropriate therapy for a subject suffering... Agent: Baker Botts L.L.P.

20090087853 - Herbicide tolerant cotton plants and methods for producing and identifying same: The invention pertains to transgenic cotton plants, plant material and seeds, characterized by harboring a specific transformation event, particularly by the presence of a gene encoding a protein that confers herbicide tolerance, at a specific location in the cotton genome. The cotton plants of the invention combine the herbicide tolerant... Agent: Hunton & Williams LLP Intellectual Property Department

20090087851 - Lineage-restricted neuronal precursors: A self-renewing restricted stem cell population has been identified in developing (embryonic day 13.5) spinal cords that can differentiate into multiple neuronal phenotypes, but cannot differentiate into glial phenotypes. This neuronal-restricted precursor (NRP) expresses highly polysialated or embryonic neural cell adhesion molecule (E-NCAM) and is morphologically distinct from neuroepithelial stem... Agent: Licata & Tyrrell P.C.

20090087839 - Long distance polymerase chain reaction-based assay for detecting chromosomal rearrangements: Methods are presented for determining the presence of an inversion in the factor VIII gene which cause hemophilia A. The methods encompass long distance, multiplex PCR (including overlapping PCR). The use of deaza-dGTP, high levels of DNA polymerases and high levels of DMSO aid in successfully performing the PCR. The... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090087852 - Mammalian selenoprotein differentially expressed in tumor cells: A 15 kDa selenium-containing protein (“selenoprotein”) is disclosed. The protein is shown to be differentially expressed in cancer cells, such as prostate cancer cells. There is a correlation between the presence of a polymorphism at nucleotide positions 811 and 1125 of the 15 kDa selenoprotein gene, and the presence of... Agent: Klarquist Sparkman, LLP

20090087855 - Markers of alterations in the y chromosome and uses therefor: Novel sequence tagged sites (STSs), probes and primers useful, e.g., for detecting the presence or absence of an STS in a sample, and methods of using these STSs, probes and primers, e.g., in methods of detecting alterations in the Y chromosome are disclosed. These compositions are also useful in methods... Agent: Morse, Barnes-brown & Pendleton, P.C. Attn:IPManager

20090087856 - Method for administering anticoagulation therapy: The present invention provides a method for use in treating a patient with an anticoagulant to optimize drug therapy and/or to prevent an adverse drug response. More particularly, the present invention relates to a method and system for use in treating a patient with Coumadin® or a substance containing warfarin.... Agent: Quarles & Brady LLP

20090087834 - Method for characterising polynucleotides: The method of the invention is used to identify specific characteristics of a target polynucleotide in a sample, and comprises the steps of: i) attaching to one end of each target polynucleotide in the sample a polynucleotide signal sequence that is specific for the characteristic under study; ii) contacting the... Agent: Marshall, Gerstein & Borun LLP

20090087846 - Method for detecting large mutations and duplications using control amplification comparisons to paralogous genes: Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090087837 - Method of detecting streptococcus pneumoniae, primer set for the detection and kit for the detection: A method of detecting Streptococcus pneumoniae, which is characterized in that it comprises amplifying a lytA gene derived from S. pneumoniae using a LAMP primer set comprising at least one primer having a nucleotide sequence that is identical to or complementary to a partial sequence in the region ranging from... Agent: Birch Stewart Kolasch & Birch

20090087835 - Method of identifying hairpin dna probes by partial fold analysis: Method of identifying molecular beacons in which a secondary structure prediction algorithm is employed to identify oligonucleotide sequences within a target gene having the requisite hairpin structure. Isolated oligonucleotides, molecular beacons prepared from those oligonucleotides, and their use are also disclosed.... Agent: Nixon Peabody LLP - Patent Group

20090087844 - Methods and compositions for correlating genetic markers with cardiovascular disease: b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods... Agent: Myers Bigel Sibley & Sajovec

20090087841 - Methods and compositions for determining resistance of hiv-1 to protease inhibitors: This invention relates to methods for determining resistance of HIV-I viruses to protease inhibitors (PIs) based on the viral genotypes. The methods generally comprise detecting, in a gene encoding protease of the HIV-I, the presence of a mutation in at least one of codon 22, 69, 74, or 83 alone... Agent: Jones Day

20090087854 - Methods for genetic analysis: Methods of treating an individual exhibiting a medical condition are disclosed. The methods involve determining a score of an individual based on the individual's genotypic information, comparing the score to at least one threshold value, wherein the result of the comparison is indicative of a beneficial response to a treatment,... Agent: Goodwin Procter LLP Attn: Patent Administrator

20090087857 - Molecular beacons for dna-photography: The present invention refers to a detection method for analytes using the principle of black-and-white photography and to reagent kits for performing the method, furthermore applied this new technology to detect a biologically relevant sequence in the nanomolar range (femtomoles) in an application circumventing the necessity of a PCR. There... Agent: Brinks, Hofer, Gilson & Lione

20090087843 - Molecular markers: The present invention relates to genetic sequences exhibiting differential expression patterns in cancer tissue relative to normal tissue. The identification of such sequences permits their use as molecular markers for cancer, as early indicators of cancer progression and/or as predictive markers for a propensity or likelihood of a cancer to... Agent: Dann, Dorfman, Herrell & Skillman

20090087850 - Nucleic acid sequencing methods and systems: Sequencing methods that use an exonuclease that comprises template dependent nucleobase binding activity are provided. Related compositions and sequencing systems are also provided.... Agent: Quine Intellectual Property Law Group, P.C.

20090087849 - Nucleic acid-based methods and compositions for the detection of ovarian cancer: Methods and compositions for identifying ovarian cancer in a patient sample are provided. The methods of the invention comprise detecting overexpression or underexpression of at least one nucleic acid biomarker in a body sample, wherein the biomarker is selectively overexpressed or underexpressed in ovarian cancer. The body sample may be,... Agent: Alston & Bird LLP

20090087842 - Presynaptic protein cast: The present invention enabled the detection and quantification of CAST, which is localized to synapses and tightly bound to the cytomatrix, and of the mRNA encoding the CAST. Furthermore, it was revealed that CAST functions as a protein scaffold for localizing RIM1 to synapses, contributing as a molecular basis for... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090087858 - Two-color real-time/end-point quantitation of micrornas (mirnas): The present invention is directed to methods, reagents, kits, and compositions for detecting target polynucleotide sequences, especially small target polynucleotides such as miRNAs, between two samples. A pair of linker probes can be employed in two different reactions to query a particular species of target polynucleotide. A pair of detector... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090087862 - Chemical sensing device: The present invention relates to chemical sensing and in particular to a method for detecting an analyte in a sample of whole blood. The method comprise, in summary, the steps of: exposing the sample to a transducer having a tethered reagent; introducing a labelled reagent; irradiating the sample with a... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090087861 - Chimeric tymovirus-like particles and process thereof: The present disclosure relates to chimeric tymovirus-like particles (TVLPs) comprising a fusion protein that further comprises of a first protein that is a truncated tymovirus coat protein and a second protein. These chimeric TVLPs are useful as antigens. The present disclosure provides a highly efficient means for differentiating Foot and... Agent: Reinhart Boerner Van Deuren P.C.

20090087860 - Highly sensitive system and methods for analysis of prostate specific antigen (psa): The invention described herein provides methods, compositions, kits, and systems for the sensitive detection of prostate specific antigen. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of prostate specific antigen.... Agent: Wilson Sonsini Goodrich & Rosati

20090087859 - Microfluidic device for detecting soluble molecules: The present disclosure provides a microfluidic device that is compatible with standard centrifuges and may be used for point-of-care disease detection. The detection methodology may be based on microELISA.... Agent: Clark & Elbing LLP

20090087874 - Glucose dehydrogenase and production thereof: The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression systems.... Agent: Norris, Mclaughlin & Marcus, Pa

20090087873 - Sharply resolving labeled protein molecular weight standards: Pre-labeled protein standards useful in electrophoresis that have sharp, consistent separation characteristics that are substantially the same as those of their unlabeled counterparts are provided. The invention provides pre-labeled protein standard sets that include a plurality of labeled proteins that are labeled on a first amino acid, in which side... Agent: Invitrogen Corporation C/o Intellevate

20090087875 - Alzheimer's related proteins and methods of use: Disclosed is a method for identifying substances that alter the interaction of a presenilin protein with a presenilin-binding protein, including contacting at least the interacting domain of a presenilin protein to a presenilin-binding protein in the presence of a test substance, and measuring the interaction of the presenilin protein and... Agent: Ropes & Gray LLP

20090087876 - Methods and compositions useful for modulating drug-induced impairment: The present invention provides isolated nucleic acids, polypeptides, oligonucleotides, vectors, host cells, antibodies, compositions, and kits relating to happyhour. Also provided are methods of screening for agents capable of modulating happyhour activity.... Agent: Jones Day

20090087877 - Infectivity assay: There is provided a method for infecting a target cell with a TSE agent, comprising: i) contacting said target cell with a membrane preparation, wherein the membrane preparation comprises the TSE agent and a donor membrane; and ii) infecting said target cell with the TSE agent. There is also provided... Agent: Evan Law Group LLC

20090087879 - Method for the production of a lysate used for cell-free protein biosynthesis: The invention relates to a method for producing a lysate used for cell-free protein biosynthesis, comprising the following steps: a) a genomic sequence in an organism, which codes for an essential translation product that reduces the yield of cell-free protein biosynthesis, is replaced by the foreign DNA located under a... Agent: Mayer & Williams PC

20090087880 - Method for the production of a lysate used for cell-free protein biosynthesis: A process for expression of active [FeFe]-hydrogenase in a host organism that does not contain either the structural gene(s) for [FeFe]-hydrogenases and/or homologues for the maturation genes HydE, HydF and HyG, comprising: cloning the structural hydrogenase gene(s) and/or the maturation genes HydE, HydF and HydG from an organisms that contains... Agent: Paul J White, Patent Counsel National Renewable Energy Laboratory (nrel)

20090087881 - Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same: Oncokinase fusion polypeptides associated with hyperproliferative disorders and the polynucleotides encoding for such fusion polypeptides are provided. The fusion polypeptides have a C-terminal tyrosine kinase domain fused to an N-terminal domain that is not normally fused to the C-terminal tyrosine kinase domain and they possess constitutively activated tyrosine kinase activity.... Agent: Theravance, Inc.

20090087882 - Protein secretion in eukaryotic cells: The invention relates to the use of a glucosidase II mutation to increase protein secretion in yeast cells. The invention relates further to the use of yeast cells, comprising a mutant glucosidase II gene, possibly in combination with the expression of a recombinant α-1,2-mannosidase gene and/or a recombinant N-acetylglucosaminyl-transferase gene,... Agent: Trask Britt

20090087883 - Novel expression vector with enhanced gene expression capacity and method for using the same: The present invention provides a novel expression vector which comprises a gene of interest, a nuclear anchoring element, and at least one inverted repeat element, preferably two inverted repeat elements. The expression vector is an episomal vector capable of transfecting a mammalian cell. The present invention further provides a method... Agent: Andrews & Kurth, L.L.P.

20090087884 - Microfluidic nucleic acid amplification and separation: Microfluidic devices designed for assaying biochemical molecules are disclosed. The microfluidic devices are capable of assaying nucleic acids for identification of nucleic acid species. The microfluidic devices are adapted to carry out an amplification of the nucleic acid and subsequent separation of amplified nucleic acid species. Also disclosed is a... Agent: Agilent Technologies Inc.

20090087836 - Il-b30 antibodies: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Dnax Research Inc. Legal Department

20090087878 - Nucleic acid molecules associated with plants: Polynucleotides useful for improvement of plants are provided. In particular, polynucleotide sequences are provided from plant sources. Polypeptides encoded by the polynucleotide sequences are also provided. The disclosed polynucleotides and polypeptides find use in production of transgenic plants to produce plants having improved properties.... Agent: Gail P. Wuellner Monsanto Company

20090087885 - Process for preparing optically active amino acids using a whole-cell catalyst: The present invention relates to a process for preparing, in particular, enantiomerically enriched L-α-amino acids, in particular those of the general formula (I). In this connection, the process according to the invention uses 2-ketocarboxylic acids which are converted into the desired products using a whole-cell catalyst which comprises an amino... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090087886 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the sfmacdfh-fimz cluster or the fimz gene: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the sfmACDFH-fimZ cluster and/or the fimZ gene.... Agent: Cermak & Kenealy LLP Acs LLC

20090087887 - Method for producing l-amino acid: An L-amino acid is produced by culturing an L-amino acid-producing bacterium which belongs to the Enterobacteriaceae family and which has been modified so that the acetyl-CoA synthetase activity is increased.... Agent: Cermak & Kenealy LLP Acs LLC

20090087888 - Production of monatin stereoisomers: Methods and materials for the production of the high intensity sweetener, monatin, in stereoisomerically-pure or stereoisomerically-enriched form are disclosed. For example, methods using stereoisoselective hydrolysis and separation of a monatin-derived lactone ester are disclosed.... Agent: Fish & Richardson P.C.

20090087889 - Methods and compositions for growth hydrocarbons in botryococcus sp.: Bottom dwelling colonies of Botryococcus are stimulated to produce and accumulate unusually high hydrocarbon concentrations that make them float to the surface. When exposed to carbon dioxide gas at the surface of the water, hydrocarbon induced flotation and growth is further enhanced with concomitant provision of appropriate light and available... Agent: Nields, Lemack & Frame, LLC

20090087890 - Methods of producing organic products with photosynthetic organisms and products and compositions thereof: Provided herein are compositions and methods for producing products by photosynthetic organisms. The photosynthetic organisms can be genetically modified to effect production, expression, or both, of products. The methods and compositions are particularly useful in the petrochemical industry.... Agent: Wilson Sonsini Goodrich & Rosati

20090087891 - Methods and device for producing hydrogen from biomass: Disclosed herein are methods of producing molecular hydrogen, where the methods comprise contacting a solution comprising urea with a urease to produce ammonia, and contacting the ammonia with a first catalyst to produce a first gaseous mixture comprising molecular hydrogen.... Agent: Biotechnology Law Group C/o Portfolioip

20090087892 - Methods for producing mutant microbes useful for precious metal and bioenergy production: A mutant microbe that generates trace amounts of gold on silver, and uses of the mutant microbe for producing and recovering precious metals and for producing biofuels and oil products from biomass and sedimentary organic matter are described. According to an exemplary embodiment, the mutant microbe is produced by placing... Agent: Raymond Owyang

20090087893 - Modified expandase enzyme and its use: The present invention relates to a mutant penicillin expandase which comprises an amino acid substitution at one or more residue positions corresponding to those of a wild-type expandase selected from the group consisting of threonine at position 42, isoleucine at position 50, histidine at position 57, threonine at position 67,... Agent: Oliff & Berridge, PLC

20090087894 - Method for improving enzymatic activity of glycosyltransferases: e

20090087895 - Expression vectors for producing tag-cleavable fusion proteins in multiple expression systems: This invention features a kit containing multiple expression vectors for producing tag-cleavable fusion proteins in various expression systems, or for producing fusion proteins in E. coli inclusion bodies.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090087896 - Live bacteria liquid product applicator and remote management system therefore: An applicator machine for applying a liquid carrier having live bacteria suspended therein, which are in a dormant state, to a target host comprising a pump having inlet and discharge sides, with the inlet side of the pump being in fluid communication with the liquid carrier. A first fluid conduit... Agent: Thomte Law Office, L.L.C.

20090087897 - Prevention of bacterial growth in fermentation process: A fermentation process for the production of ethanol from natural sources, such as corn, comprising introducing a fermentable sugar, an inoculant, and a stabilized chlorine dioxide into a fermentation system is disclosed. The stabilized chlorine dioxide is added preventatively to the fermentation system, at concentrations in the fermentation system of... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090087898 - Methods, processes and apparatus of sequestering and environmentally coverting oxide(s) of carbon and nitrogen: The instant invention presents improved means for sequestering COX and/or NOX in the aqueous phase of a gas scrubber. The instant invention presents means for the scrubbing of COX and/or NOX gas by chemically assimilating at least one of COX and NOX. The instant invention presents means for concentrating the... Agent: Richard A. Haase (inventor)

20090087899 - Method and structure for extracting molecular species: The present invention in one embodiment provides a method for extracting molecular material including providing a probe comprising a penetration portion having a nanoscale surface for penetrating a biological compartment, a receptor present on the penetrating portion of the probe, wherein the receptor has an affinity for a target molecular... Agent: Scully Scott Murphy & Presser PC

20090087900 - Apparatus for performing electrodistention on algae cells: Two apparatuses capable of performing electroporation are disclosed. The first apparatus uses a Marx generator with a substantial change from its original waveform. The second apparatus does not use a Marx generator.... Agent: Dillon & Yudell LLP

20090087901 - Analytical test element and method for blood analyses: An analytical test element for blood analyses is provided having an application site and a microfluidic channel structure in fluid communication with the application site. The channel structure comprises at least first and second analytical channels for receiving first and second portions of a blood sample applied to the application... Agent: Roche Diagnostics Operations Inc.

20090087902 - Methods and compositions for rapidly detecting and quantifying viable legionella: Methods and compositions detect and quantify viable Legionella. Dip-slides that include an absorbent medium, growth promoting, and growth selective substances are useful in rapid detection and quantification of microcolonies of Legionella. Most probable number method of detection and quantification of Legionella are disclosed.... Agent: Barnes & Thornburg LLP

20090087903 - Temperature control device with a flexible temperature control surface: A device for controlling temperature in a reaction chamber is disclosed. The device comprises: a bladder assembly comprising a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing; and a first temperature-control bladder disposed within the housing, the first temperature-control bladder is configured to... Agent: Andrews Kurth LLP

20090087904 - Apparatus for handling and classifying microtomized tissue samples: The invention relates to an apparatus for handling microtomized tissue samples (1) which are arranged on an object carrier (2) and are provided with a machine-readable code (3), with a reader (4) serving to detect the information of the code (3) and a controller (5) serving to convert the information... Agent: Kohler Schmid Moebus

20090087905 - Vegf-d polynucleotides and methods of use: VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it,... Agent: Marshall, Gerstein & Borun LLP

20090087906 - Novel cell-based assays for g-protein-coupled receptor-mediated activities: Disclosed are compositions and methods for their use, such as in identifying G-protein-coupled receptors, ligands and compounds that modulate the activities of G-protein-coupled receptors. The compositions and methods employ cyclic nucleotide-gated channels and fluorescence dyes in detecting changes of intracellular cAMP levels in response to the stimulation of G-protein-coupled receptors.... Agent: Bozicevic, Field & Francis LLP

20090087907 - Compositions and methods for growth of pluripotent cells: A method of propagating embryonic stem (ES) cells in an undifferentiated state, while maintaining both the pluripotency and the cells normal genotype is disclosed. The method comprises using recombinantly produced protein domains to attach human embryonic stem cells to the surface of a bioreactor. The ES cells are supplied with... Agent: Bozicevic, Field & Francis LLP

20090087908 - Methods for stratification and storage of somatic embryos: In one aspect, a method is provided for producing stratified cotyledonary conifer somatic embryos. The method comprises (a) incubating a culture comprising immature conifer somatic embryos in a culture vessel comprising a development medium having an osmolality in the range of from 300 mM/Kg to 450 mM/Kg at a temperature... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

20090087909 - Use of trehalose in conifer somatic embryogenesis to increase germination vigor: In one aspect, a method is provided for increasing germination vigor of conifer somatic embryos produced in vitro. The method comprises (a) culturing a plurality of immature conifer somatic embryos for a first incubation period in, or on, a first development medium that comprises less than 0.1% trehalose; and (b)... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

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