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Chemistry: molecular biology and microbiology March listing by industry category 03/09

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
03/26/2009 > patent applications in patent subcategories. listing by industry category

20090081631 - Tissue engineered organ: Tissue engineered organs and methods for producing the same are provided. The tissue engineered organs are useful to replace diseased or damaged host organs.... Agent: Clay Fette

20090081632 - Method for enriching rare cell subpopulations from blood: An antigen-dependent negative selection blood cell separation method is described. Rare circulating epithelial cells can be separated from blood by depleting erythrocytes from a blood sample. Erythrocytes are depleted by agglutination. The new method comprises the use of an agglutinating agent, such as an anti-glycophorin A or glycophorin B antibody,... Agent: Steptoe & Johnson LLP

20090081634 - Fluorescent and saccharidic substrates, their process of preparation and their use: The present invention relates to fluorescent enzymatic substrates of saccharidic nature having a self-cleavable spacer arm functionalized by a fluorophore F and by at least one inhibitor of the fluorescence of F, to the use thereof for preparation of a diagnostic reagent for functional imaging in vivo, and to the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090081635 - Modified heparinase iii and methods of sequencing therewith: The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention.... Agent: Wolf Greenfield & Sacks, P.C.

20090081633 - Seed testing method and apparatus: A saturated cold germination test kit includes a compartment base, a lid and a holder for an oxygen scavenger. The base is water and airtight and includes a liquid gas exchange control trough around its perimeter. It is sized to house a high moisture holding seed planting surface pack at... Agent: Vincent L. Carney Law Office

20090081639 - Assay for sensitivity to chemotherapeutic agents: Diagnostic methods for assaying the efficacy of chemotherapeutic agents in vitro for the treatment of cancer and methods for identifying chemotherapeutic agents are provided. The methods employ reporter viruses. Combinations and kits for use in the practicing the methods are also provided.... Agent: Bell, Boyd & Lloyd LLP

20090081637 - Hepatitis b viral variants with reduced susceptibility to nucleoside analogs and uses thereof: The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral... Agent: Baker Botts L.L.P.

20090081638 - Immobilisation of antigenic carbohydrates to support detection of pathogenic microorganisms: The invention relates to the field of chemistry and diagnosis, more in particular to diagnosis of current and/or past and/or symptomless infections or of a history of exposure to, a gram-negative-bacterium (such as an enterobacteriaceae or a legionella). Even more in particular, the invention relates to the screening of animals... Agent: Trask Britt

20090081641 - Methods and systems for treating disease: Methods and systems described herein are applicable to the identification of pathogens, pathogenic variants and applicable treatments or remedies. In some embodiments, the pathogen or pathogens bears a causal relationship to a disease state.... Agent: Searete LLC Clarence T. Tegreene

20090081640 - Methods of using mirna for detection of in vivo cell death: Described are non-invasive methods of detecting in vivo cell death by measuring levels of ubiquitous and tissue specific miRNA. The method can be applied for detection of pathologies caused or accompanied by cell death, as well as for diagnosis of infectious disease, cytotoxic effects induced by different chemical or physical... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris, Glovsky & Popeo, P.C.

20090081636 - Pharmaceutical compositions for and methods of inhibiting hcv replication: The present invention relates generally to replicase complex defect inducers and pharmaceutical compositions containing such inducers. Methods of developing mutants that are resistant to replicase complex defect inducers are also provided. Further included are mutants that can be used in screening for replicase complex defect inducers. Methods of screening test... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20090081661 - Alkyl amines improve detection of components of formaldehyde-fixed biological samples: Alkyl amines act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting alkyl amines to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization.... Agent: Townsend And Townsend And Crew, LLP

20090081679 - Compositions and methods for in vivo selex: The invention describes methods for the in vivo selection of oligonucleotides, preferably aptamers, that persist in biological compartments. In one embodiment, the biological compartment comprises at least one tissue which, in a preferred embodiment, is the blood within the circulatory system of a living mammal. The invention also contemplates oligonucleotides,... Agent: Mintz, Levin, Cohn, Ferris, Glovskyand Popeo, P.C.

20090081660 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Goodwin Procter LLP Attn: Patent Administrator

20090081652 - Constitutively translocating cell line: The present invention relates to agonist-independent methods of screening for compounds that alter GPCR desensitization. Included in the present invention are cell lines containing GRKs, in which GPCRs are desensitized in the absence of agonist; the GRKs may be modified. The present invention relates to methods to determine if a... Agent: Morgan, Lewis & Bockius, LLP

20090081648 - Detection and analysis of influenza virus: An assay comprising more than one primer pair and more than one detection probe, a low copy number synthetic amplicon corresponding to each of the primer pairs. The assay can detect and distinguish between various sub-types and strains of an influenza virus using any suitable nucleic acid amplification technique. Related... Agent: Foley And Lardner LLP Suite 500

20090081647 - Detection of a genetic predisposition to cancers and non-cancerous pathologies in mammals: Methods are provided for the detection of susceptibility to cancer and non-cancerous pathologies in a mammal. Diagnostic kits are also provided.... Agent: Brooks, Cameron & Huebsch , PLLC

20090081684 - Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives: Novel methods allowing for the simple optical and electrochemical detection of double-stranded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they do not require any chemical reaction on the probes or on the analytes since they are based on different electrostatic interactions between cationic poly(3-alkoxy-4-methylthiophene) derivatives and... Agent: Knobbe Martens Olson & Bear LLP

20090081649 - Diagnostic method for detecting cancer by measuring amount of cytokine like il -6: The present invention relates to a diagnostic method for predicting the possible recurrence of tumours in cancer patients. The method comprises culturing blood cells from a patient suffering from cancer in the presence of a cytokine stimulating factor, where after the amount of induced cytokine thereby produced is determined giving... Agent: Young & Thompson

20090081669 - Fluorescent assays using orthogonal trna - aminoacyl synthetase pairs: An unnatural amino acid comprising a fluorescent moiety is site-specifically incorporated into a protein through the use of an O-tRNA/O-RS pair which is orthogonal to the tRNAs and aminoacyl synthetases of a translation system, thereby allowing the protein to be analyzed.... Agent: Sheldon Mak Rose & Anderson PC

20090081658 - Genemap of the human genes associated with crohn's disease: The present invention relates to the selection of a set of polymorphism markers for use in genome wide association studies based on linkage disequilibrium mapping. In particular, the invention relates to the fields of pharmacogenomics, diagnostics, patient therapy and the use of genetic haplotype information to predict an individual's susceptibility... Agent: Ralph A. Dowell Of Dowell & Dowell P.C.

20090081672 - Genes from the 20q13 amplicon and their uses: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.... Agent: Weaver Austin Villeneuve & Sampson LLP

20090081657 - Genetic identification and validation of echinacea species: A method for identification and validation of Echinacea is disclosed. Primers are designed based on information analysis of sequences from a large number of Echinacea species to amplify certain segments of genomic DNA to identify the species. Primers and methods are also disclosed to amplify other plant species that are... Agent: Lathrop & Gage Lc

20090081668 - Glycosyltransferase, nucleic acid encoding the glycosyltransferase and method of testing canceration using the nucleic acid: A tumor marker nucleic acid of the present invention is concerned with a nucleic acid hybridizing under stringent conditions to a nucleotide sequence described in SEQ ID NO: 1 or a complementary nucleotide sequence thereof. A method of testing canceration of the present invention is a method comprising diagnosing a... Agent: Nixon & Vanderhye, PC

20090081682 - High-throughput methods for identifying gene function using lentiviral vectors: The present invention relates to methods and compositions for the efficient identification of one or more functionalities of a product encoded by a nucleic acid sequence of interest. The methods utilize the abilities to over and/or under express the product in a cell, as well as the combination of these... Agent: Virxsys C/o Mofo Sd

20090081662 - Homogeneous luminescence bioassay: This invention relates to a homogenous bioassay for use in measurement of biological activity, its modulation or analyte concentration of a sample, said bioassay comprising a first group comprising an acceptor, which acceptor is a short lifetime fluorescent compound capable of energy transfer, and a second group comprising a quencher,... Agent: James C. Lydon

20090081653 - Insulin-responsive dna binding proteins-1 and methods to regulate insulin-responsive genes: The present invention relates to the novel protein Insulin-Responsive DNA Binding Protein-1 (IRDBP-1) and nucleotide sequences that encode it. IRDBP-1 binds to nucleic acid regions of genes that respond when cells are exposed to insulin. IRDBP-1 regulates genes important in mediating the insulin response in mammals and in regulating conditions... Agent: Ipc Intellectual Property Connections, Inc.

20090081683 - Kits and methods for assessing the coenzyme q reducing status of a patient, including a patient ingesting a statin: The disclosure relates to kits and methods for assessing whether an individual is likely to benefit from nutritional supplementation with coenzyme Q and, more particularly, a reduced form of coenzyme Q. The methods involve assessing occurrence of a polymorphism in the gene encoding NQO1 in the individual. Individuals homozygous for... Agent: Brandy C Hill

20090081644 - Ligation amplification: Provided herein are methods and agents for ligation-based exponential ribonucleic acid amplification followed by detection using a nucleic acid polymerization reaction employing terminal-phosphate-labeled nucleotides including three or more phosphates as substrates for nucleic acid polymerase.... Agent: General Electric Company Global Research

20090081671 - Method and apparatus for judging the presence or absence of cancer cell: The invention provides a method for judging whether cancer cells are present or not in a sample, comprising a obtaining step of obtaining values related to an expression level of a caner marker gene and a housekeeping gene; a first comparing step of comparing the value related to the expression... Agent: Sughrue Mion, PLLC

20090081656 - Method for detecting a bacterial pathogen: A method is provided for detecting a bacterial pathogen in a sample. One step of the method includes obtaining a sample and then subjecting the sample to nested PCR. The nested PCR is conducted in the presence of at least two outer oligonucleotide primers complementary to a target nucleotide sequence... Agent: Tarolli, Sundheim, Covell & Tummino, LLP

20090081664 - Method for detecting reaction product of nucleic acid synthesis: A method for detecting the occurrence of nucleic acid syntheses using an enzyme through the use of a generated insoluble substance as an indicator.... Agent: Fish & Richardson P.C.

20090081677 - Method for gender identification of eagles with probe-based real-time pcr and the sequences used for gender identification of eagles: A method for gender identification of eagles includes: providing a DNA of an eagle; performing a probe-based real-time PCR using the DNA as a template, a universal primer pair P2/P8 as a primer pair and a first probe and a second probe as probes, wherein the 5′ ends of the... Agent: Pai Patent & Trademark Law Firm

20090081681 - Method for genetic selection of high-plasmid producing e. coli clones: The present invention relates to methods of selecting for highly productive clones of E. coli for the production of plasmid DNA comprising measuring the frequency of IS1 transposon insertional mutagenesis within either the plasmid or genomic DNA of transformed clonal subtypes. An increase in IS1 insertional mutagenesis is correlated with... Agent: Merck And Co., Inc

20090081650 - Method for identifying nucleotide sequences, use of the method and test kit: A method is disclosed for identifying nucleotide sequences while using non-labeled free oligonucleotides, labeled free and hybridizable oligonucleotides and non-labeled and immobilized oligonucleotides.... Agent: Harness, Dickey & Pierce, P.L.C

20090081645 - Method of assuming drug sensitivity to cdk4 inhibitor: It is intended to provide a gene for assuming drug sensitivity, which is to be used for assuming the drug sensitivity to a CDK4 inhibitor based on the expression amount in a test tissue or a test cell, selected from the group consisting of p16 gene, p18 gene and p27... Agent: Merck And Co., Inc

20090081665 - Method of diagnosis/prognosis of human chronic lymphocytic leukemia comprising the profiling of lpl/adam genes: The present invention provides methods of diagnosis and prognosis of human chronic lymphocytic leukemia (CLL) in a subject a patient in need thereof. The methods of the present invention involve measuring the expression profile of two known genes: LPL and ADAM29; and comparing the ratio of their expression to diagnose... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090081685 - Methods and compositions for the detection of ovarian disease: Methods and compositions for identifying ovarian cancer in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in ovarian cancer. In preferred embodiments, the body sample is a serum sample. The... Agent: Alston & Bird LLP

20090081674 - Methods for analysis of pdef and survivin as interconnected cancer biomarkers and targets for personalized medicine: Provided are methods for determining whether an individual is a candidate to receive treatment with a DNA methylation inhibitor. The method can be performed a biological sample of cancerous tissue of the individual. Determining that PDEF expression is absent or low and survivin expression is present identifies the individual as... Agent: Hodgson Russ LLP The Guaranty Building

20090081643 - Methods for evaluating ribonucleotide sequences: Methods for identifying ribonucleotide sequences, in vitro, using the ribosome-mediated translation, are provided.... Agent: Heslin Rothenberg Farley & Mesiti PC

20090081651 - Methods for isolating and characterizing endogenous mrna-protein (mrnp) complexes: Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex and include cell cultures, cell extracts, and whole tissue, including tumor... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090081688 - Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations: Methods of detecting multiple nucleic acid targets in single cells through indirect capture of labels to the nucleic acids are provided. Methods of assaying the relative levels of nucleic acid targets through normalization to levels of reference nucleic acids are also provided. Methods of detecting individual cells, particularly rare cells... Agent: Quine Intellectual Property Law Group, P.C.

20090081676 - Methods of using fet labeled oligonucleotides that include a 3'-5' exonuclease resistant quencher domain and compositions for practicing the same: Methods and compositions are provided for detecting a primer extension product in a reaction mixture. In the subject methods, a primer extension reaction is conducted in the presence of a polymerase having 3′→5′ exonuclease activity and at least one FET labeled oligonucleotide probe that includes a 3′→5′ exonuclease resistant quencher... Agent: Invitrogen Corporation C/o Intellevate

20090081663 - Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria: The present invention relates generally to detection of antibiotic-resistant bacteria in a sample. In particular, the invention provides methods, compositions and kits for detecting and analyzing methicillin-resistant Staphylococcus aureus (MRSA) and other methicillin-resistant bacteria in a sample.... Agent: Morgan, Lewis & Bockius LLP (sf)

20090081675 - Methods, compounds and systems for detecting a microorganism in a sample: Methods to identify a set of probe polynucleotides suitable for detecting a set of targets and in particular methods for identification of primers suitable for detection of target microorganisms related polynucleotides, set of polynucleotides and compositions, and related methods and systems for detection and/or identification of microorganisms in a sample.... Agent: Llnl/steinfl & Bruno John H. Lee, Assistant Laboratory Counsel

20090081655 - Multiplex real-time quantitative pcr: Disclosed are compositions and methods for analyzing multiple nucleic acids using PCR.... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20090081680 - Mutant firefly luciferase: This invention relates to: the development of a mutant firefly luciferase in order to use dATP as a DNA polymerase substrate upon pyrosequencing, such luciferase being subjected to substrate specificity modification in a manner such that the dATP-induced activity alone is decreased while the ATP-induced activity is maintained; and a... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090081670 - Nicking and extension amplification reaction for the exponential amplification of nucleic acids: The invention is in general directed to the rapid exponential amplification of short DNA or RNA sequences at a constant temperature.... Agent: Grant Anderson LLP C/o Portfolioip

20090081642 - Novel apoptosis gene ei24, compositions, and methods of use: Disclosed is the isolation and characterization of EI24, a novel gene whose 2.4 kb mRNA is induced following etoposide treatment. Induction of EI24 mRNA by etoposide required expression of wild-type p53. Overexpression of functional p53 was sufficient to induce expression of the EI24 mRNA. The EI24 mRNA was also induced... Agent: Wilmerhale/dc

20090081678 - Nucleic acid isolation in preserved whole blood: A method for isolating nucleic acids is disclosed, wherein a sample having nucleic acid containing starting material is fixed, lysed, and treated to remove unwanted contaminants. The initial fixing of the sample aids in maintaining the structure and integrity of the isolated DNA and reduces the incidence of end product... Agent: Dobrusin & Thennisch PC

20090081687 - Nucleic acid molecules and other molecules associated with plants: Expressed Sequence Tags (ESTs) isolated from soybean are disclosed. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The disclosed ESTs have utility in the development of new strategies for understanding critical plant developmental and metabolic pathways. The disclosed... Agent: Arnold & Porter LLP

20090081686 - Photocleavable labeled nucleotides and nucleosides and methods for their use in dna sequencing: Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3′-OH group is derivatized at the nucleobase to include a fluorescent dye attached via a linker... Agent: Fulbright & Jaworski L.L.P.

20090081673 - Platensimycin biosynthetic gene cluster of streptomyces platensis: The present invention relates to the cloning and sequence of a biosynthetic gene cluster from Streptomyces platensis that produces platensimycin and platencin. Also provided are engineered micro-organisms for the production of these compounds, and analogs thereto, as well as methods of screening for compounds with anti-bacterial activity.... Agent: Fulbright & Jaworski L.L.P.

20090081666 - Probe set, probe carrier, and method for determining and identifying fungus: It is intended to provide a method for identifying a causative fungus of skin disease. The method includes: simultaneously performing amplification treatments under the same conditions using primers common to plural fungal species; then simultaneously performing hybridization procedures under the same conditions using probes respectively specific to fungi; and determining... Agent: Fitzpatrick Cella Harper & Scinto

20090081689 - Reagents and methods to enrich rare cells from body fluids: The present invention relates to compositions and methods for separating cells. The present invention utilizes a combination of techniques to deplete non-nucleated and nucleated cells in a biological sample. The use of this invention assists in reducing the complexity of a biological sample such as peripheral blood, and help in... Agent: David R Preston & Associates Apc

20090081659 - Reagents for the detection of protein phosphorylation in carcinoma signaling pathways: The invention discloses 364 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Simona Levi-minzi, Ph.d. General Counsel

20090081690 - Site-specific labeling of proteins for nmr studies: Methods of producing and/or analyzing spectroscopically labeled proteins, e.g., proteins site-specifically labeled with NMR active isotopes, spin-labels, chelators for paramagnetic metals, and the like, are provided. The labeled proteins are produced in translation systems including orthogonal aminoacyl tRNA synthetase/tRNA pairs. Methods for assigning NMR resonances, e.g., methods using isotopically labeled... Agent: Quine Intellectual Property Law Group, P.C.

20090081654 - Transfection kinetics and structural promoters: The invention features methods of analyzing the kinetics properties of transfection reactions. Also featured are methods for creating structural promoters which are effectively unregulated by enhancers and repressors. The structural promoters are significantly more active than the native promoter sequences upon which they are based.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090081646 - Universal primers and their use for detecting and identifying plant materials in complex mixtures: The invention relates to polynucleotides and primers flanking a variable region of the intron of the chloroplast gene trnL of plant materials for detecting and identifying plant species. The invention also relates to methods for detecting and identifying plant species in complex or degraded mixtures.... Agent: Oliff & Berridge, PLC

20090081667 - Viral variants with altered susceptibility to nucleoside analogs and uses thereof: The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside analogs and/or reduced interactivity with antibodies to viral surface components... Agent: Baker Botts L.L.P.

20090081692 - Ceramide kinase loop: An isolated polynucleotide of SEQ ID NO:1, an isolated polypeptide of SEQ ID NO:2, e.g. encoded by a polynucleotide of SEQ ID NO:1, a vector comprising such polynucleotide, an expression system, comprising such polynucleotide, a host cell comprising such expression system, the use of a such polypeptide or polynucleotide as... Agent: Novartis Institutes For Biomedical Research, Inc.

20090081696 - Luminescence enhancer and use thereof: An object of the present invention is to provide a luminescence enhancer by which a luminescence such as chemiluminescence can be enhanced with higher sensitivity and the luminescence can be continued over a prolonged period of time. That is, the present invention provides a luminescence enhancer containing a heteropolymer as... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090081691 - Method of identifying transmembrane protein-interacting compounds: A method for screening compounds for their ability to interact with transmembrane proteins is provided. Also provided is a method for determining whether proteins such as transmembrane proteins are able to oligomerise.... Agent: Bereskin And Parr

20090081695 - Methods and compositions for detection of ehrlichia chaffeensis (p120): The invention provides methods and compositions for the detection of Ehrlichia chaffeensis.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090081697 - Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, and methods of rationally designing or identifying antibiotics using structure coordinate data derived from such crystals: Methods of growing crystals of free and antibiotic complexed large ribosomal subunits, coordinates defining the 3D atomic structure thereof and methods of utilizing such coordinates for rational design or identification of antibiotics or large ribosomal subunits having desired characteristics are disclosed.... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.

20090081694 - Modified well plates for molecular binding studies: Microtiter plates modified to permit their use for molecular binding studies.... Agent: Trex Enterprises Corp.

20090081693 - Molecule associating with intracellular c-terminal domain of receptor: As a result, a novel cytoplasmic protein associating directly and specifically with the Pro-12-C-terminal domain of CCR2 is found out and it is clarified that this protein forms clusters with CCR2 after stimulation with CCL2. Thus, it is confirmed that there is a novel signal transduction system in the G... Agent: Birch Stewart Kolasch & Birch

20090081698 - High throughput cell-based assays, methods of use and kits: In the present invention cells are placed in a multiwell plate and grown. When the assay is to be performed, one uses gravity to wash away any unbound ligands rather than vacuum or centrifugation. The cells are then examined to detect the bound ligand. To perform the washing step(s) the... Agent: Millipore Corporation

20090081701 - Method of selective protein enrichment and associated applications: The present invention provides methods of selective enrichment of ligands present in a biological sample. One or a plurality of receptor carriers are used to capture ligands capable of binding to receptors immobilized on the surface of the receptor carriers. Receptor carriers bound with the ligands are separated from the... Agent: Law Offices Of Albert Wai-kit Chan, PLLC

20090081699 - Methods and compositions for risk stratification: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090081700 - Methods of use of the taci/taci-l interaction: The invention discloses a novel interaction between a TNF receptor (TACI) and its interacting ligand (TACI-L). Also disclosed are methods of screening candidate molecules to determine potential antagonists and agonists of the TACI/TACI-L interaction. The use of the antagonists and agonists as therapeutics to treat autoimmune diseases, inflammation, and to... Agent: Immunex Corporation Law Department

20090081707 - Human trk receptors and neurotrophic factor inhibitors: The invention concerns human trkB and trkC receptors and their functional derivatives. The invention further concerns immunoadhesins comprising trk receptor sequences fused to immunoglobulin sequences.... Agent: Goodwin Procter LLP

20090081708 - Methods and compositions for detection of ehrlichia chaffeensis (vlpt): The invention provides methods and compositions for the detection of Ehrlichia chaffeensis.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090081710 - Method for cancer prognosis using cellular folate vitamin receptor quantification: The invention relates to a method for determining a prognosis for a cancer by quantifying vitamin receptor expression on the cancer cells. The method comprises the steps of quantifying vitamin receptor expression on the cancer cells, and determining a prognosis for the cancer. The invention also relates to methods and... Agent: Barnes & Thornburg LLP

20090081709 - Protein markers of responsiveness to type iii receptor tyrosine kinase inhibitors: The invention discloses ten (10) protein markers predictive of cancer resistance or responsiveness to Type III Receptor Tyrosine Kinase (RTK) inhibitors, and provides methods for identifying a cancer that is likely to be resistant to a Type III RTK-inhibiting therapeutic by examining expression and/or activity of one or more of... Agent: Simona Levi-minzi, Ph.d. General Counsel

20090081711 - Addressable antibody arrays and methods of use: Systems and assay methods are disclosed for detecting an autoantibody in a sample. In certain instances, the systems and methods employ a mass tag releasably connected to an antigen. The tag is thereafter released for detection. A tag can be detected by mass spectrometry or in certain instances the tag... Agent: Townsend And Townsend And Crew, LLP

20090081704 - Compositions, methods and kits for real-time enzyme assays using charged molecules: Compositions, methods and kits useful for, among other things, detecting, quantifying and/or characterizing enzymes.... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090081702 - Discriminaton of cardiac dysfunction in pregnant females: The present invention relates to a method for diagnosing if a pregnant woman suffers from a cardiac dysfunction, comprising the steps of a) measuring the level of a natriuretic peptide in a sample b) measuring the level of placental growth factor and/or sFlt-1 or a variant thereof in a sample,... Agent: Roche Diagnostics Operations Inc.

20090081703 - Method for detecting deep venous thrombosis: A method for detecting deep vein thrombosis (DVT) in humans includes the steps of assaying a collected blood sample and measuring the amount of Lp-PLA2. The detected amount of Lp-PLA2 is then compared and correlated with known risk values of Lp-PLA2. A diagnosis of a patient's likelihood, risk, or development... Agent: Boyle Fredrickson S.c.

20090081706 - Crystalline form of the catalytic domain of aurora 2 kinase and methods of use thereof: The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20090081705 - Novel peptides and compositions which modulate apoptosis: The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the “GD domain,” which is essential both... Agent: Wilmerhale/dc

20090081712 - Atm-dependent phosphorylation of sp1 is involved in the cellular response to dna damage and enhances cellular survival after dna damage: The present invention is related to the discovery that phosphorylation of SP1 (SEQ ID NO.: 2) at serine residue 101 (known herein as phosphoserine101 Sp1) is an important part of a cell's response to DNA damage. This phosphorylation event is important for subsequent Sp1 localization to a site of DNA... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20090081713 - Peptide biomarkers predictive of renal function decline and kidney disease: The presently-disclosed subject matter provides methods for diagnosing a kidney disease, or the risk thereof, in a subject. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in... Agent: Stites & Harbison, PLLC

20090081714 - Assays: Methods and assays for monitoring the cardiac health of a subject are provided. The method involves the detection of a urotensin surrogate in a sample leading to a more accurate and reliable diagnosis of early or late stages of decompensated heart failure, heart failure, risk of a heart failur in... Agent: Steptoe & Johnson LLP

20090081715 - Engineered light-emitting reporter genes: Compositions and methods are provided for enhanced expression of light emitting reporters. Such reporters are used in methods for monitoring cultures for production of target compounds.... Agent: Wilson Sonsini Goodrich & Rosati

20090081716 - Method for monitoring the immune response and predicting clinical outcomes in transplant recipients: Methods for monitoring the immune response and predicting clinical outcomes for patients on immunosuppressive drugs (such as transplant patients) are provided. The methods are based on the measurement of an intracellular metabolic marker in lymphocytes (such as ATP) as an indicator of a patient's immune response.... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20090081717 - Compositions and methods for signal generation: Improved assay systems comprise a substrate that is modified to include a solubilizing group and/or an at least binary solvent system to provide significantly enhanced signal strength and signal-to-noise ratio. In especially preferred aspects, the assay system is a chromogenic, electrochemical, and/or luminogenic assay system in which an indoxyl-type substrate... Agent: Fish & Associates, PC Robert D. Fish

20090081718 - Protein cleavage method and thereof: The present invention provides a method for cleaving a glycated protein to obtain an amino acid or a peptide efficiently with a protease. By treating the glycated protein with the protease in the presence of a compound represented by R—X, the amino acid or the peptide is obtained by the... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090081719 - Biochemical markers for acute pulmonary embolism: The present invention relates to a method of differentiating between a singular and a multiple lung embolism in a subject suspected to suffer from acute lung embolism comprising determining the amount of NT-proBNP in a sample of a subject suspected to suffer from acute lung embolism and comparing the amount... Agent: Roche Diagnostics Operations Inc.

20090081720 - Methods for identifying stem cells based on nuclear morphotypes: Methods for identifying stem cells and other cells specific to embryogenesis and carcinogenesis, classifying tissue samples, diagnosing precancerous and cancerous or atherosclerotic lesions, testing the value of anticancer agents, discovering macromolecules specifically expressed in particular cell types, using stem cells in restorative tissue therapy as well as methods for preparing... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090081721 - High-throughput cell assays: This invention provides high-through put methods and systems to identify and/or classify cells present in a sample. In one aspect, the method identifies the cell by determining the amount of thermal energy required to disrupt cell membranes. In another aspect, a method is for determining if an agent such as... Agent: Foley & Lardner LLP

20090081722 - Site-specific labeling of affinity tags in fusion proteins: The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula A(B)n, wherein A is a fluorophore, B is a binding domain that is a charged chemical... Agent: Invitrogen Corporation C/o Intellevate

20090081723 - Bioreactor, cell culture method, and substance production method: The present invention achieves a smaller difference between a dissolved oxygen concentration in an upper part of a culture tank and a dissolved oxygen concentration in a lower part of the culture tank. The present invention comprises: a culture tank; a sparger means arranged in a lower part of the... Agent: Mattingly, Stanger, Malur & Brundidge, P.C.

20090081730 - Activatable recombinant neurotoxins: Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.... Agent: Allergan, Inc.

20090081732 - Antibodies to human il-1beta: An IL-1β binding molecule, in particular an antibody to human IL-1β, especially a human antibody to human IL-1β is provided, wherein the CDRs of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-1 mediated disease or disorder, e.g. osteoarthritis, osteoporosis... Agent: Novartis Corporate Intellectual Property

20090081727 - Cd33-like protein: The present invention concerns a novel CD33-like protein. In particular, isolated nucleic acid molecules are provided encoding the CD33-like protein. Recombinant CD33-like polypeptides are also provided as are recombinant vectors and host cells. The invention further provides methods useful during tumor or inflammatory disease diagnosis or prognosis and therapeutic treatments... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20090081729 - Compositions and methods comprising a ligand of chemerinr: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related... Agent: Edwards Angell Palmer & Dodge LLP

20090081725 - Compositions of pamps and listeria monocytogenes and methods of use: A composition comprising a pathogen associated molecular pattern (PAMP) protein that activates toll-like receptor 2 (TLR2) or toll-like receptor 5 (TLR5) signaling and at least two distinct antigens of Listeria monocytogenes. Amino acids, nucleotides, vectors, cell lines, and the methods for production and use of the compositions are provided.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090081731 - Method of producing catalytically active bace2 enzymes: The invention provides methods and compositions for the efficient expression and isolation of BACE2 polypeptides from inclusion bodies and its refolding to an active enzyme.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090081724 - Mutations in ion channels: A method of identifying a subject predisposed to a disorder associated with ion channel dysfunction, comprising ascertaining whether at least one of the genes encoding ion channel subunits in said subject has undergone a mutation event as set forth in one of SEQ ID Numbers: 1-72.... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20090081728 - Production of attenuated negative stranded rna virus vaccines from cloned nucleotide sequences: Attenuated, recombinant negative stranded RNA viruses suitable for vaccine use are produced from one or more isolated polynucleotide molecules encoding the virus. A recombinant genome or antigenome of the subject virus is modified to encode a mutation within a recombinant protein of the virus at one or more amino acid... Agent: Birch, Stewart, Kolasch & Birch, LLP

20090081726 - Recombinant microorganism: Also provided is a recombinant microorganism obtained by introducing into a host microorganism a gene encoding a heterologous protein or polypeptide, wherein in said host microorganism the Bacillus subtilis aprX gene or a gene corresponding to the aprX gene has been deleted or knocked out, and a method for producing... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090081733 - Methods for producing and using polymyxins: The present invention provides methods for producing a polymyxin from an isolated Paenibacillus amylolyticus, and methods for using the polymyxin, including methods for producing a recombinant polypeptide.... Agent: Mueting, Raasch & Gebhardt, P.A.

20090081734 - Arabinitol dehydrogenases from neurospora crassa: Stable and active arabinitol dehydrogenases (LAD) from Neurospora crassa and mutants thereof are disclosed. Arabinitol dehydrogenases are useful in the production of xylitol and ethanol from an arabinose containing substrate. Recombinant and heterologously expressed arabinitol dehydrogenases are useful in converting biomass into biofuels and other industrial food products.... Agent: Barnes & Thornburg LLP

20090081735 - Novel process: Novel organisms, including DNA construct host cell combinations, are disclosed. The organisms comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for enzymes which promote the supply of single carbon units for the conversion of dUMP to dTMP. Examples include: dihydrofolate reductase genes e.g. T4 frd; Serine Hydroxymethyltransferase genes... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B482

20090081737 - Methods and compositions for reducing the complexity of a nucleic acid sample: Aspects of the present invention are drawn to methods and compositions for sorting nucleic acid molecules into physically separate compartments according to the identity of a nucleotide base or sequence of bases at a specific location, resulting in the production of reduced complexity samples that find use in any number... Agent: Bozicevic, Field & Francis LLP

20090081736 - Methods for using mutant rna polymerases wtih reduced discrimination between non-canonical nucleoside triphosphates: A method for synthesizing a nucleic acid molecule comprising at least one non-canonical nucleoside triphosphate using a mutant polymerase having a reduced discrimination between canonical and non-canonical substrates is disclosed. The method comprises incubating a template nucleic acid in a reaction mixture comprising the mutant nucleic acid polymerase and the... Agent: Quarles & Brady LLP

20090081738 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family having expression of the bola gene attenuated: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea, which has been modified to attenuate expression of the bolA gene.... Agent: Cermak & Kenealy LLP Acs LLC

20090081739 - Process for producing amino acids: The present invention provides: a process for producing an amino acid which comprises adding crystals of the amino acid having an average particle size of 1 to 120 μm to a medium so that the concentration of the crystals of the amino acid becomes 0.5 g/l or more, culturing a... Agent: Fitzpatrick Cella Harper & Scinto

20090081740 - Production of amino acids from sucrose in corynebacterium glutamicum: Methods and compositions for increased production of amino acids from C. glutamicum using sucrose as a carbon source are described. In one aspect, increased production of L-lysine from C. glutamicum is accomplished by using a strain having a mutation in the ptsF gene encoding fructose-PTS enzyme that attenuates or blocks... Agent: Buchanan Ingersoll & Rooney PC (archer Daniels Midland Company)

20090081741 - Single colonies of myxobacteria cells: A single colony of myxobacterium cells, a process for its production and its use. A process for the production of a myxobacterium Sorangium strain (Sorangium cellulosum) having an improved epothilone production rate. A process for the production of epothilone B using the aforementioned strain. A process for the production of... Agent: Novartis Corporate Intellectual Property

20090081742 - High efficiency separations to recover oil from microalgae: A system and method for processing algae cells to create biofuel are disclosed. Specifically, the system and method utilize steam to rupture algae cells in order to utilize intracellular oil therein. The system includes a conduit for growing algae cells and a generator for creating steam. Further, the system includes... Agent: Nydegger & Associates

20090081744 - Method of processing slops: A method of processing slops including production of biogas characterized in that slops are exposed to anaerobic fermentation in a anaerobic fermenter under generation of biogas and at least a portion of the biogas containing methane and carbon dioxide is fed into a first photo-bioreactor, where the carbon dioxide or... Agent: Collard & Roe, P.C.

20090081743 - Transportable algae biodiesel system: A portable system and method for producing biofuel from algae are disclosed. In the portable system, a chemostat and a plug flow reactor formed from plastic bladders are interconnected. Further, an algae separator is in fluid communication with the plug flow reactor for removing algae cells. Also, the system includes... Agent: Nydegger & Associates

20090081745 - Method for producing 1,3-propanediol and 2,3-butanediol from raw starch material: The invention discloses a method for producing 1,3-propanediol and 2,3-butanediol from raw starch materials, including the following steps: 1) Candida krusei or Hansenula Arabitolgens Fang are inoculated into a fermentation medium with the saccharifying liquid of the raw starches as a carbon source; the yeast cells are cultured on an... Agent: Knobbe Martens Olson & Bear LLP

20090081746 - Biofuel production by recombinant microorganisms: Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol, 1-propanol, 2-methyl-1-butanol, 3-methyl-1-butanol and 2-phenylethanol from a suitable substrate.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20090081747 - Ethanol from corn and use of distiller grains by-product to produce fuel gas: A process for substantially increasing the production of ethanol from corn and other such biomass feedstocks. Ethanol, carbon dioxide and distiller grains are typically produced during the fermentation process. The carbon dioxide is used as a feed for additional ethanol make and the distiller grains can be used as a... Agent: Stanley R. Pearson

20090081748 - Integrated processes and systems for production of biofuels using algae: A process for production of biofuels from biomass can include depolymerizing a biomass to form a feed. The feed can be formed by autotrophically growing algal biomass and extracting the feed therefrom. The algal feed can be converted to an algal oil by introducing the algal feed to an oil-producing... Agent: Thorpe North & Western, LLP.

20090081749 - Process for producing ethanol from corn dry milling: A process for producing ethanol by the conversion of carbohydrates from a corn dry milling process in which the bottoms fraction from distillation of ethanol in a conventional yeast fermentation is used in a process including a combination of biochemical and synthetic conversions. The process results in high yield ethanol... Agent: Sheridan Ross PC

20090081750 - Transfection in magnetically driven continuous flow: Biological cells and other membranous structures are transfected in a flow-through system by first rendering the structures magnetically active such that they respond to a magnetic field, suspending the structures in a solution of an exogenous species with which the structures are to be transfected, then placing the suspension in... Agent: Townsend And Townsend And Crew, LLP

20090081751 - Natively glycosylated mammalian biological molecules produced by electromagnetically stimulating living mammalian cells: A composition is disclosed with the composition comprising a mixture of natively glycosylated mammalian biological molecules produced by electromagnetically stimulating living mammalian cells.... Agent: Ladas & Parry LLP

20090081752 - Bioreactor, kit and method of using same: A bioreactor, kit, a method of using the device to promoting growing and/or culture of a cell, and a method for regenerating and/or improving the function of mammalian cells. The bioreactor includes a controlling circuit coupled to magnetic field emitter that emits relatively steep and short-lived magnetic field pulses during... Agent: Ladas & Parry LLP

20090081753 - Method for formulating and immobilizing a matrix protein and a matrix protein for use in a sensor: A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical strength properties. The method includes cross-linking and hardening the protein... Agent: Foley & Lardner

20090081755 - Fragrant consumer products comprising oxidizing agents: Fragrant consumer products comprising oxidizing agents are described, which may be, for example, detergents or cleaners or, for example, also cosmetics. These consumer products comprise certain minimum amounts of fragrances of certain classes of substances. They are characterized by very good (storage) stability, both with regard to the fragrance of... Agent: Connolly Bove Lodge & Hutz LLP

20090081754 - Gene of enzyme having activity to generate lachrymatory factor: It is an object of the present invention to provide isozymes of the lachrymatory factor producing enzyme, the amino acid sequences of these isozymes and a gene that codes for these amino acid sequences, and the present invention relates to three types of isozymes of the lachrymatory factor producing enzyme... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090081757 - Adsorbents comprising anthraquinone dye-ligends for the separation of biological materials: A process for the separation of biological materials, such as dye-ligand affinity chromatography, wherein an adsorbent is used, which comprises a reaction product of certain reactive anthroquinone compounds and a substrate having a group capable of reaction with a reactive group in said reactive anthroquinone compounds to form a covalent... Agent: Joann Villamizar Ciba Corporation/patent Department

20090081758 - Chimeric cytochrome p450 proteins and methods of use: The present invention provides chimeric cytochrome P450 enzymes fused to heterologous reductase domains to generate single-component, self-sufficient, more cost-effective and catalytically more active biosynthetic P450 monooxygenases.... Agent: Marshall, Gerstein & Borun LLP

20090081759 - Nucleic acid encoding a novel ribonuclease having an amino acid sequence made up of the amino acid sequence of a known ribonuclease and an n-terminal leader sequence that is at least one residue long: A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in United States Patent U.S. Pat. No. 6,239,257 B1 is preceded by a different N-terminal residue or leader sequence.... Agent: Mark H. Jay, P.A.

20090081756 - Nucleic acid-enzyme complex: The present inventors designed a nucleic acid-enzyme complex using GGA 12-mer (Reference 3), which was found in the laboratory of the inventors to have greatly changeable structure in the presence or absence of monovalent metal ion as well as previously known nucleic acid-enzyme. The present invention is a deoxyribozyme complex... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20090081760 - Dmo methods and compositions: The invention provides for identification and use of crystal structures of Dicamba monooxygenase (DMO) that may be complexed with iron or cobalt cofactor and substrate (dicamba), or product (DCSA) in order to define residues important for enzymatic structure and function. Methods of using such structures are described. Data storage media... Agent: Sonnenschein Nath & Rosenthal LLP

20090081761 - Modified hydrogenase, enzymatic electrode made of modified hydrogenase, and hydrogenase modification method: The invention provides: (1) a modified hydrogenase obtained by removing electron-transfer sites from a hydrogenase constituted of: active subunits including active sites having a hydrogen oxidization-reduction activity; and electron-transfer subunits having the electron-transfer sites through which electrons are transferred between the active sites and the outside of the hydrogenase; (2)... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090081762 - Superactive cellulase formulation using cellobiohydrolase-1 from penicillium funiculosum: Purified cellobiohydrolase I (glycosyl hydrolase family 7 (Cel7A)) enzymes from Penicillium funiculosum demonstrate a high level of specific performance in comparison to other Cel7 family member enzymes when formulated with purified EIcd endoglucanase from A. cellulolyticus and tested on pretreated corn stover. This result is true of the purified native... Agent: Paul J White, Patent Counsel National Renewable Energy Laboratory (nrel)

20090081763 - Novel protein-deamidating enzyme, microorganism producing the same, gene encoding the same, production process therefor, and use thereof: A method for the production of an enzyme, which comprises culturing in a medium a strain that belongs to a bacterium classified into Cytophagales or Actinomycetes, or a new bacterium Chryseobacterium sp. No. 9670 belonging to the genus Chryseobacterium, and has the ability to produce an enzyme having a property... Agent: Edwards Angell Palmer & Dodge LLP

20090081764 - Heterologous g protein coupled receptors expressed in yeast, their fusion with g proteins and use thereof in bioassay: The present invention is directed to expression vectors and yeast cells transformed therewith containing a first heterologous nucleotide sequence which codes for a G protein-coupled receptor, for example, the somatostatin receptor, and a second nucleotide sequence which codes for all or a portion of a G protein αβγ complex. Said... Agent: Wyeth/finnegan Henderson, LLP

20090081765 - Cell electrophysiological sensor and method for manufacturing the same: In a cell electrophysiological sensor having a thin plate with a through hole, a support plate with a through hole and a container plate with a through hole stuck to an upper portion of this support plate, the support plate and the container plate are stuck to each other through... Agent: Ratnerprestia

20090081766 - Micro bio sensor and method for manufacturing the micro bio sensor: A micro bio sensor which detects a microbe existing in a specimen is provided. The microbial sensor includes a base, a detector formed on the base, and a reaction layer formed on the detector, wherein the reaction layer is comprised of a self-assembled monolayer which is formed on the detector... Agent: Harness, Dickey & Pierce, P.L.C

20090081767 - Endoscope sterilization evaluation device: An endoscope sterilization evaluation device is provided with an elongated hollow body having a hollow portion opened at opposite ends, the elongated hollow body simulating an endoscope having a tubular passage, an exterior member having a first housing portion in which a biological indicator for performing sterilization evaluation on the... Agent: Scully Scott Murphy & Presser, PC

20090081768 - Devices and methods for thermally isolating chambers of an assay card: An assay card and devices and methods for isolating chambers on the assay card are described. The assay card comprises a substrate formed of one or more materials, e.g., plastic, having a softening temperature, the substrate defining channels communicating with respective reaction chambers. The assay card may be heated in... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090081769 - Apparatus for judging cell detachment, method of judging cell detachment, and cell culture apparatus: An apparatus for judging cell detachment that judges a state of detachment of cells that have been cultured within a cell culture container (cultured cells), includes: an image-capturing unit that captures an image of the cultured cells; and a detachment state judging unit that determines luminance information within the cell... Agent: Oliff & Berridge, PLC

20090081770 - High throughput bioreactor: A continuous flow bioreactor system that includes a bioreactor, an optional post-bioreactor preparation chamber, a cell sorter, and an optional pre-bioreactor preparation chamber in a closed loop, useful for enriching a heterogeneous cell population growing in the bioreactor with an isolated subpopulation of cells.... Agent: Mueting, Raasch & Gebhardt, P.A.

20090081771 - System and method for heating, cooling and heat cycling on microfluidic device: An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material.... Agent: Seed Intellectual Property Law Group PLLC

20090081772 - Method and device for collecting cellular material from cells isolated on a filter:

20090081774 - Automated staining and decolorization of biological material: An improved method and apparatus for staining samples of biological material for accurate analysis of the sample. Biological material is applied to a substrate, such as a microscope slide. The biological specimen is then stained with a selected staining composition, which may be gentian violet for a Gram's Stain analysis.... Agent: Storm LLP

20090081773 - Microfluidic apparatus for manipulating imaging and analyzing cells of a cytological specimen: A microfluidic apparatus for isolating and imaging or analyzing cells of a cytological specimen includes a substrate and a microfluidic cellular isolation element that includes an outer wall, a channel, a partition member and a receptacle. The partition member is positioned within the isolation element interior, and the receptacle is... Agent: VistaIPLaw Group LLP

20090081775 - Microscope system and screening method for drugs, physical therapies and biohazards: Method and device for automated cell analysis and determination of transport and communication between living cells by analyzing the formation of tunneling nanotubes (TNTs) between cells. This method comprising the steps of singularizing cells in a culture medium and staining the cells with a fluorescent or luminescent dyes for staining... Agent: Birch Stewart Kolasch & Birch

20090081778 - Nucleic acid encoding a fusion protein incorporating a cysteinized ribonuclease: A nucleic acid encodes a novel fusion protein. The fusion protein contains a cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1.... Agent: Mark H. Jay, P.A.

20090081776 - Nucleic acid encoding a novel ribonuclease having an amino acid sequence made up of the amino acid sequence of a known ribonuclease and an n-terminal leader sequence that is at least one residue long: A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in U.S. Pat. No. 6,239,257 B1 is preceded by a different N-terminal residue or leader sequence.... Agent: Mark H. Jay, P.A.

20090081777 - Nucleic acid encoding cysteinized ribonuclease to which a targeting moiety can be conjugated: A nucleic acid encodes a cysteinized RNase to which a targeting moiety can be conjugated.... Agent: Mark H. Jay, P.A.

20090081779 - Tumor suppressor gene, p28ing5: This disclosure provides a novel tumor suppressor, referred to as p28ING5, nucleic acid molecules encoding this protein, and methods of making and using these molecules. Also provided are methods of ameliorating, treating, detecting, prognosing, and diagnosing diseases and conditions associated with abnormal p28ING5 expression, such as neoplasia. Kits are also... Agent: Klarquist Sparkman, LLP

20090081780 - Canine respiratory coronavirus (crcv) spike protein, polymerase and hemagglutinin/esterase: A canine respiratory coronavirus (CRCV) that is present in the respiratory tract of dogs with canine infectious respiratory disease and which has a low level of homology to the enteric canine coronavirus, but which has a high level of homology to all bovine coronavirus strains (e.g., Quebec and LY138) and... Agent: Knobbe Martens Olson & Bear LLP

20090081781 - Synthetic and standardized prion infectuous material, and uses thereof as an injecting inoculum: The invention concerns a novel, synthetic, standardised, soluble, reproducible and easy-to-handle infectious material of the prion type, consisting of a cell lysate or culture supernatant from stable transgenic cells expressing a prion protein PrP and supporting replication of the pathogenic form, PrPsc, of the said Prp.... Agent: Birch Stewart Kolasch & Birch

20090081782 - Methods for vitrification of human oocytes: Provided are methods for the vitrification of human oocytes, which comprises: (a) placing human oocytes on a transfer instrument; and (b) placing the transfer instrument and the human oocytes directly into a slushed nitrogen (N2 slush), wherein the human oocytes are directly exposed to the N2 slush thereby undergoing vitrification,... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090081784 - Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions: Methods for obtaining multipotent mesenchymal stem cells under serum-free conditions and methods for identifying multipotent mesenchymal progenitor cells are disclosed.... Agent: Quarles & Brady LLP

20090081783 - Method for producing langerhans cells or interstitial dendritic cells or both from cd14+ monocytes: t

20090081785 - Desiccated biologics and methods of preparing the same: The present invention provides compositions comprising desiccated biologics comprising a cell, protein, virus, nucleic acid, carbohydrate, or lipid, or any combination thereof, along with at least one membrane penetrable sugar, and at least one membrane impenetrable sugar, wherein the moisture content is from 5% to 95%, and to methods of... Agent: Pepper Hamilton LLP

20090081789 - Activation of nuclear factor kappa b: The present invention describes a method for targeting a tumor cell comprising contacting the tumor cell with a composition comprising a macrophage and a factor that upregulates nuclear factor-kappa B (NFκB) activity.... Agent: Foley And Lardner LLP Suite 500

20090081787 - Agent for promoting hepatic cell replication and agent for improving insulin resistance: The present invention aims at providing a medicament and a method for promoting replication of hepatocytes and a medicament and a method for ameliorating insulin resistance. An effective amount of a neutralizing agent for CXCL10 belonging to a subfamily of chemokines which are heparin-binding proteins is administered to the hepatocytes... Agent: Sughrue Mion, PLLC

20090081788 - Nucleotide sequence encoding the enzyme i-scei and the uses thereof: An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090081786 - Peptide sequences for modulation of protein kinase c: Peptides found within an annexin protein can be used to modulate the activity of a protein kinase C are described. More particularly, peptides within annexin I, V, and VI, as well as variants and conservatively modified variants thereof, are described, and use of these peptides to regulate cellular responses mediated... Agent: King & Spalding LLP

20090081790 - Polynucleotide for target gene: The present invention provides a single strand polynucleotide sequence comprising a target gene, a complementary strand nucleic acid sequence, and a component sequence.... Agent: Sughrue Mion, PLLC

20090081791 - Intracellular delivery of small molecules, proteins, and nucleic acids: An amino acid sequence Arg-Lys-Met-Leu-Lys-Ser-Thr-Arg-Arg-Gln-Arg-Arg (SEQ ID NO:1) functions as a protein transduction domain (PTD) and is capable of delivering small molecules, proteins, and nucleic acids to an intracellular compartment of a cell. An amino terminal lysine linker improves the efficiency of the PTD. A nuclear localization signal can be... Agent: Banner & Witcoff, Ltd.

20090081792 - Immune potentiating compositions of cancer cells: A composition of matter is disclosed, comprising an immunostimulatory molecule and animal cells cultured in the presence of at least one interferon (IFN) for a time and under conditions sufficient to enhance the antigen presenting function of said cells. Also disclosed are immunopotentiating compositions and their use for treatment and/or... Agent: Knobbe Martens Olson & Bear LLP

20090081793 - Method for improving acid and low ph tolerance in yeast: A method for increasing tolerance in yeast to organic acids and low pH comprising functionally transforming a yeast with at least one copy of a nucleotide sequence encoding a plasma membrane H+-ATPase.... Agent: Ratnerprestia

  
03/19/2009 > patent applications in patent subcategories. listing by industry category

20090075248 - Particle sensor with wide linear range: This invention provides a novel methods and devices for measurement of particle concentration or changes in particle concentration over a wide linear range. The invention comprises one or more radiation sources and one or more detectors contained in a housing which is interfaced to a medium containing particulate matter. The... Agent: Quine Intellectual Property Law Group, P.C.

20090075249 - Engineering beta-ketoacyl acp synthase for novel substrate specificity: Methods of altering substrate specificity of beta-ketoacyl-ACP synthase, and engineered beta-ketoacyl-ACP synthases so produced are provided. DNA sequences and constructs for expression of engineered beta-ketoacyl-ACP synthases, as well as the novel beta-ketoacyl-ACP synthases produced therefrom are also provided. Such DNA sequences may be used for expression of the engineered beta-ketoacyl-ACP... Agent: Arnold & Porter LLP

20090075250 - Environmental sampling and testing method: Provided is sampling and testing device for the detection of specific molds, allergens, viruses, bacteria, fungi, and other protein containing substances. Embodiments of the device include a sampling member slideably engaged with a base that contains a lateral flow strip adapted to detect specific analytes of interest. The sampling member... Agent: The Clorox Company

20090075259 - Analyte detection via antibody-associated enzyme assay: The present invention provides methods, kits, and compositions for the detection of an analyte. The invention is particularly suited for the detection and quantification of an analyte in a sample. In the methods of the invention a complex is formed between an analyte specific binding agent and an analyte. The... Agent: Agilent Techologies Inc

20090075255 - Androgen regulated nucleic acid molecules and encoded proteins: The present invention provides novel androgen regulated nucleic acid molecules. Related polypeptides and diagnostic methods also are provided.... Agent: Mcdermott, Will & Emery

20090075268 - Antigenic targets of autoimmune sensorineural hearing loss (aisnhl) and development of tests for diagnosis and management of aisnhl: This invention relates generally to antigens reactive with autoantibodies associated with autoimmune sensorineural hearing loss (AISNHL), and in particular relates to a novel antigen, Inner Ear Supporting Cell Antigen (IESCA) reactive with autoantibodies associated with autoimmune sensorineural hearing loss (AISNHL), and to methods for the detecting therapeutic outcomes in treatment... Agent: Casimir Jones, S.c.

20090075282 - Artificial tissue constructs comprising alveolar cells and methods for using the same: The present invention comprises artificial tissue constructs that serve as in vitro models of mammalian lung tissue. The artificial tissue constructs of the present invention comprise functionally equivalent in vitro tissue scaffolds that enable immunophysiological function of the lung. The constructs can serve as novel platforms for the study of... Agent: Merchant & Gould PC

20090075253 - Bioreactive agents: This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise agents... Agent: Medlen & Carroll, LLP

20090075289 - Collection assembly for obtaining oral samples from an animal: The present invention provides a collection assembly for obtaining a sample from within the mouth of an animal. The collection assembly comprises a collection wand, having a scoop-shaped collecting end, and, optionally, an oral speculum. Also provided are methods of using the collection assembly to obtain an oral sample from... Agent: Townsend And Townsend And Crew, LLP

20090075278 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Goodwin Procter LLP Attn: Patent Administrator

20090075279 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Goodwin Procter LLP Attn: Patent Administrator

20090075286 - Detection of polyketide synthetase gene expression in karenia brevis: The present invention concerns an assay for the detection of polyketide synthetase (PKS) mRNA from the red tide dinoflagellate Karenia brevis. Another aspect of the invention concerns NASBA primers and a molecular beacon that enable detection of mRNA of one of the PKS genes. In another aspect, the present invention... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090075280 - Eubacterial tmrna sequences and uses thereof: The present invention is directed to eubacterial tmDNA sequences and the corresponding tmRNA sequences. The present invention is further directed to alignments of eubacterial tmDNA sequences and the use of the sequences and sequence alignments for the development of antibacterial drugs. The present invention is also directed to the use... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090075262 - Gene methylation in endometrial cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with endometrial cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of endometrial cancer.... Agent: Townsend And Townsend And Crew, LLP

20090075264 - Gene methylation in liver cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with liver cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of liver cancer.... Agent: Townsend And Townsend And Crew, LLP

20090075263 - Gene methylation in ovarian cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with ovarian cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of ovarian cancer.... Agent: Townsend And Townsend And Crew, LLP

20090075265 - Gene methylation in thyroid cancer diagnosis: The present invention provides DNA biomarker sequences that are differentially methylated in samples from normal individuals and individuals with thyroid cancer. The invention further provides methods of identifying differentially methylated DNA biomarker sequences and their use the detection and diagnosis of thyroid cancer.... Agent: Townsend And Townsend And Crew, LLP

20090075276 - High throughput mutation screening methods and kits using a universalized approach - differential sequence fill-in (dsf)-enabled sequential adapter ligation and amplification: This disclosure teaches high throughput mutation screening methods allowing simultaneous analysis of multiple genetic regions of interest and sensitive detection of very low frequency mutation(s) by the use of a universalized approach. Methods comprise treating RNA:DNA heteroduplexes of interest with a ribonuclease, sequence extension by an RNA-primed DNA polymerase, ligation... Agent: Ming-sheng Lee

20090075267 - K-ras and b-raf mutations and anti-egfr antibody therapy: The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to B-raf mutations, to polynucleotides encoding mutant B-raf polypeptides, to vectors containing those polynucleotides, and to methods of identifying B-raf mutations. The present application also... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090075284 - Metabolomic profiling of prostate cancer: The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer.... Agent: Casimir Jones, S.c.

20090075251 - Method for analysis of cytosine methylation: A method for the analysis of cytosine methylations in DNA is described. Here, the DNA to be investigated is first chemically or enzymatically converted. Then a promoter is introduced into the DNA. After this, the DNA is converted to RNA. The methylation pattern of the DNA can be concluded in... Agent: Kriegsman & Kriegsman

20090075288 - Method for de novo detection of sequences in nucleic acids: target sequencing by fragmentation: The present invention provides a method for determining nucleic acid sequences of a template nucleic acid that requires no prior knowledge of the nucleic acid sequence present in the template nucleic acid. The method is based on combining information about the mass of a fragment, the mass of any one... Agent: Ronald I. Eisenstein

20090075277 - Method for detecting ovarian cancer and method for suppressing the same: ABSTRACT An object of the present invention is to provide a method for detecting cancer through identification of genes exhibiting characteristic behavior in the cases of cancer such as ovarian cancer, and a cell growth inhibitor. The present invention provides a method for detecting cancer, which comprises detecting canceration including... Agent: Birch Stewart Kolasch & Birch

20090075272 - Method to identify cd40-sensitive cells using gene expression: Gene expression patterns were analyzed in CD40-sensitive and CD40-resistant diffuse large-cell B-lymphoma (DLCBL) cell lines to identify signaling pathways which are involved in CD40-mediated apoptosis. CD40-resistant lines expressed pre-B cell markers including RAG and VPREB, whereas CD40-sensitive cells resembled mature B-cells and expressed higher levels of transcripts encoding several members... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090075260 - Methods and nucleic acids for analysis of cellular proliferative disorders: Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of... Agent: Davis Wright Tremaine, LLP/seattle

20090075287 - Methods for identifying novel pesticidal gene homologues: Methods and compositions for identifying novel pesticidal gene homologues are provided. Specifically, the methods of the invention comprise systematically designing oligonucleotide primers that are specific for a pesticidal gene of interest and performing successive rounds of PCR amplification of nucleic acid material from a microorganism, particularly a Bacillus thuringiensis strain,... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20090075252 - Methods for increasing accuracy of nucleic acid sequencing: The invention provides methods for improving the fidelity of a sequencing-by-synthesis reaction by resequencing at least a portion of a nucleic acid template.... Agent: Edwards Angell Palmer & Dodge LLP

20090075271 - Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke: e

20090075258 - Methods of normalization in microrna detection assays: This application describes methods of quantifying a target miRNA in a biological sample by measuring the amounts of a target miRNA and at least one reference oncomir in a reaction volume, and normalizing the amount of target miRNA to the amount of one or more reference oncomirs.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090075281 - Mtbe genes: The present invention provides methods and compositions for modulating MTBE degradation. The invention also provides methods for identifying compounds that modulate MTBE expression.... Agent: Townsend And Townsend And Crew, LLP

20090075266 - Multiple analyte diagnostic readout: The invention provides methods for assessing clinical status through the creation of a diagnostic readout based upon the analysis of multiple biomarkers. According to the invention, an algorithm is provided that allows the use of multiple biomarker thresholds from a patient sample to be used in order to increase the... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090075274 - Multiplexed quantitative detection of pathogens: The invention allows for the quantitative detection of a plurality of pathogens in a single sample. The method includes the amplification of a sample with a plurality of pathogen-specific primer pairs to generate amplicons of distinct sizes from each of the pathogen specific primer pairs. The method further includes the... Agent: Mark J. Fitzgerald

20090075257 - Novel nucleic acid sequences and methods of use thereof for diagnosis: Novel splice variant nucleic acid and amino acid sequences are provided. The novel splice variants and their nucleic acid sequences may be used for diagnosis of variant-detectable diseases particularly cancerous diseases.... Agent: Fennemore Craig

20090075256 - Nucleic acid accessible hybridization site identification using mass spectrometry: The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes using mass spectrometry. The present invention also provides methods and compositions for identifying oligonucleotides with desired hybridization properties to nucleic acid... Agent: Casimir Jones, S.c.

20090075275 - Nucleic acid probe-immobilized substrate and method of detecting the presence of target nucleic acid by using the same: e

20090075254 - Physiogenomic method for predicting diabetes and metabolic syndromes induced by psychotropic drugs: The invention is generally directed to a physiogenomic method for predicting diabetes and metabolic syndromes induced by psychotropic drugs. In one embodiment, the invention relates to the use of genetic variants of marker genes to predict the likelihood that an individual will experience undesirable metabolic side effects as a result... Agent: Cantor Colburn, LLP

20090075273 - Planar waveguide detection chips and chambers for performing multiple pcr assays: Provided are planar waveguide (“PWG”) detection chips that are used to perform multiplex PCR and kinetic PCR assays with a single fluorescent dye. The PWG detection chips are housed in PWG detection chambers that house at least one PWG chip. The PWG detection chambers may be in a single chamber... Agent: Siemens Corporation Intellectual Property Department

20090075285 - Primer kit: The aim of the present invention is to provide a primer kit capable of efficiently amplifying only a required target nucleotide sequence without shortage or excess in the case of amplifying a wide range of target nucleotide sequences. The present invention is directed to a primer kit having a plurality... Agent: Scully Scott Murphy & Presser, PC

20090075270 - Products and methods relating to the use of the endoribonuclease kid/pemk: The invention relates to a method for engineering a nucleic acid for expression in the presence of Kid/PemK endoribonuclease comprising (i) screening the nucleotide sequence of the nucleic acid for the sequence UUACU or TTACT (ii) mutating said sequence such that there are no longer any occurrences of UUACU or... Agent: Mcandrews Held & Malloy, Ltd

20090075261 - System and method for authenticating tablets: A method for authenticating and verifying a pharmaceutical item to be genuine is described. The method for authenticating a tablet comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to a tablet or capsule. The method also comprises collecting a sample of the... Agent: Virtual Legal, P.C. Michael A. Kerr

20090075269 - System and method for high resolution analysis of nucleic acids to detect sequence variations: Provided herein are methods for assaying a biological sample for microorganisms having drug resistant and/or drug sensitive phenotypes, wherein the methods are capable of detecting resistant and sensitive phenotypes associated with known and/or unknown mutations. In some aspects, methods are provided for detecting drug resistant Myobacterium tuberculosis (MTb), including multi-drug... Agent: Fenwick & West LLP

20090075283 - Vectors and methods for cloning gene clusters or portions thereof: The present invention relates to a shuttle BAC vector for facilitating the cloning, transfer and heterologous expression of streptomycete secondary metabolite biosynthetic gene clusters. The invention also relates to a plasmid rescue method using this vector for enhancing the process of cloning biosynthetic gene clusters for secondary metabolites from streptomycetes... Agent: Wyeth Patent Law Group

20090075290 - Immunochemical determination method and determination reagent for cytochrome: An immunochemical method for the accurate measurement of the quantity of cytochrome c in a body fluid, in particular, blood, and a kit for the measurement. The quantity of cytochrome c can be measured accurately without being affected by any interfering substrate by reacting an antibody with cytochrome c in... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090075292 - Methods for identifying modulators of apoptosis: The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound that modulates an activity of Bax or Bid. In addition, the invention provides a method of identifying a Humanin-like... Agent: Mcdermott, Will & Emery

20090075293 - Methods for predicting embryo viability: The present invention provides methods for predicting the viability of an embryo or for predicting the likelihood of a negative outcome during pregnancy by identifying the presence or absence of or determining the amount of one or more pregnancy associated markers such as molecular isoforms of hCG in a sample.... Agent: Klauber & Jackson

20090075291 - Peptide-based regulation of gap junctions: The present invention relates to proteins and polypeptides that (i) have the formula A-[Wm-A]n where each A is independently a peptide of formula XXXXRXPXXXX where each X is independently any amino acid, R is arginine, and P is proline; each W is independently a linker; m is 1 or 2;... Agent: Nixon Peabody LLP - Patent Group

20090075294 - Eukaryotic mechanosensory transduction channel: The present invention provides, for the first time, nucleic acids encoding a eukaryotic mechanosensory transduction channel (MSC) protein. The proteins encoded by these nucleic acids form channels that can directly detect mechanical stimuli and convert them into electrical signals. These nucleic acids and the proteins they encode can be used... Agent: Townsend And Townsend And Crew, LLP

20090075297 - Mammalian galanin receptors: The present invention provides isolated mammalian GalR3 receptors, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the receptors using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20090075296 - Methods and compositions for assaying regulatory t cells: Methods and compositions for determining whether a T cell is a regulatory T cell and for determining whether a population of cells includes at least one regulatory T cell or a cell with the potential to become a regulatory T cell. The invention includes methods and compositions for detecting TGF-β... Agent: Morgan, Lewis & Bockius, LLP

20090075295 - Porphyrinic compounds for use in flow cytometry: The present invention provides a method of detecting (e.g., by flow cytometry) a target compound, cell or particle, wherein the target is labelled with a detectable luminescent compound. The method comprises utilizing as the detectable luminescent compound a compound comprising a porphyrinic macrocycle such as a porphyrin, chlorin, bacteriochlorin, or... Agent: Myers Bigel Sibley & Sajovec

20090075302 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Goodwin Procter LLP Attn: Patent Administrator

20090075301 - Diagnostic marker: A diagnostic marker is composed of particles that have a diameter of from 1 nm to 100 μm, the particles possessing on their surfaces a site that has a high specific bonding ability to a specific antigen residing on the mucosa of digestive cancers and a site that has a... Agent: Young & Thompson

20090075303 - Allo and auto-reactive t-cell epitopes: The present invention relates to a pharmaceutical composition for the prevention of alloimmunisation of a subject or the immunosuppression of a response elicited by alloimmunisation of a subject or an autoimmune haemolytic disease for said composition comprising an immunologically effective epitope of a rhesus protein or an immunologically active analogue... Agent: Licata & Tyrrell P.C.

20090075304 - Methods of assaying vaccine potency: The present invention is related to methods of assaying potency of a vaccine composition, wherein the potency is a pre-defined minimum level of potential biological activity for the vaccine composition. The method includes providing a vaccine composition and delivering same to an antigen presenting cell, wherein the vaccine composition is... Agent: Dunlap Codding, P.C.

20090075299 - Diagnostic methods: The present invention relates to methods of diagnosing cancerous conditions in a patient, as well as methods of monitoring the progression of a cancerous condition and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection... Agent: Scully Scott Murphy & Presser, PC

20090075298 - Method of analyzing enzyme: A method of analyzing an enzyme, comprising (1) bringing a sample suspected of containing an enzyme to be analyzed into contact with an enzyme substrate which is immobilized on an insoluble carrier and can be cleaved by the enzyme, in a liquid, (2) separating the insoluble carrier from the liquid,... Agent: Heslin Rothenberg Farley & Mesiti PC

20090075300 - Methods and compositions for the detection of cervical disease: Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical... Agent: Alston & Bird LLP

20090075306 - Diagnostic assay for detecting and monitoring age related and noise induced hearing loss: A method of detecting age related and/or noise induced hearing loss in a subject includes detecting in a biological sample from the subject the presence of cochlin antibodies; and correlating the level of detected cochlin antibodies to the presence or absence of age related and/or noise induced hearing loss in... Agent: Tarolli, Sundheim, Covell & Tummino L.L.P.

20090075305 - Diagnostic serum antibody profiling: The invention is directed to a microarray assay procedure that can be used for profiling the antibodies present in serum, plasma or blood. The assay may be used to identify antibodies and antigens that are characteristic of particular diseases or conditions. In addition, the invention includes specific antigens that are... Agent: Law Office Of Michael A. Sanzo, LLC

20090075307 - Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor: Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods... Agent: Alston & Bird LLP

20090075309 - Bisdeoxycoelenterazine derivatives, methods of use, and bret2 systems: Embodiments of the present disclosure provide for: compositions, BRET systems, kits, and the like.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20090075308 - Method for in vitro phosphorylation of trap of staphylococcus aureus and a method for screening the inhibitor of the trap phosphorylation: The present invention relates to a method for in vitro phosphorylation of TRAP derived from Staphylococcus aureus. In the present invention, the TRAP is first identified as a kinase that self-phosphorylates and is phosphorylated specifically in the presence of an oxidative metal ion such as iron, copper and zinc. Based... Agent: The Rafferty Patent Law Firm

20090075310 - Method for quantitatively determining ldl cholesterols: A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene tribenzylphenyl ethers and a cholesterol-assaying enzyme reagent so as to preferentially react cholesterols in high density- and very low density-cholesterols among lipoproteins, and subsequently determining the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090075311 - Assessing colorectal cancer by measuring hemoglobin and m2-pk in a stool sample: The present invention relates to a method aiding in the assessment of colorectal cancer. The method especially is used in assessing the absence or presence of colorectal cancer in vitro. The method is, for example, practiced by analyzing biochemical markers, comprising measuring in a stool sample the concentration of hemoglobin... Agent: Roche Diagnostics Operations Inc.

20090075312 - Assessing colorectal cancer by measuring osteopontin and carcinoembryonic antigen: The present invention relates to a method aiding in the assessment of colorectal cancer (=CRC). It discloses the use of a marker combination comprising osteopontin and carcinoembryonic antigen in the assessment of colorectal cancer. Furthermore, it especially relates to a method for assessing colorectal cancer from a liquid sample, derived... Agent: Roche Diagnostics Operations Inc.

20090075313 - Split protein fragments, split protein systems, methods of making split protein systems, and methods of using split protein systems: Split protein herpes simplex virus type 1 thymidine kinase [HSV1-TK or TK] TK fragments, split protein TK systems, methods of imaging protein-protein interactions, methods of cellular localization of proteins, methods of evaluating protein translocation and trafficking, and the like, are provided. In addition, the present disclosure includes compositions used in... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20090075314 - Single-cell biosensor for the measurement of gpcr ligands in a test sample: The present invention is related to the detection of GPCR ligands in a test sample by using a single cell biosensor expressing a GPCR. Preferably, the test sample is derived from a biological or environmental sample. This invention may be used to detect the presence of a disease or to... Agent: Morgan, Lewis & Bockius, LLP

20090075316 - Alzheimer's disease secretase, app substrates therefor and uses therefor: The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates,... Agent: Marshall, Gerstein & Borun LLP

20090075317 - Methods and compositions for modulating hepatocyte growth factor activation: The invention provides methods and compositions for modulating hepsin activity and the HGF/c-met signaling pathway, in particular by regulating pro-HGF activation by hepsin.... Agent: Genentech, Inc.

20090075315 - Novel human lysosomal protein and methods of its use: The gene associated and causative of classical late infantile neuronal ceroid lipofuscinosis (LINCL), CLN2, has been identified and characterized. The translation product of this gene is a novel protease and a deficiency in this activity results in LINCL. Identification of CLN2 will not only aid in the prevention of LINCL... Agent: Jones Day

20090075318 - Using photo-responsive surfactants to reversibly control protein aggregation with light illumination: The present invention relates to methods of inducing protein folding using light illumination. More specifically the invention relates to shape-reconstruction analysis applied to small angle neutron scattering (SANS) data that is used to determine the structure of partially-folded proteins in non-native conformations and supramolecular complexes undergoing self- or hetero-association in... Agent: Hogan & Hartson L.L.P.

20090075319 - Method of detecting reactive metabolite: A method of detecting a reactive metabolite which comprises steps of conducting a metabolic reaction of a test compound in the presence of two labeled nucleophiles, and detecting the label of the nucleophiles bound to the reactive metabolite, and a method of detecting a reactive metabolite which further comprises separating... Agent: Merck And Co., Inc

20090075321 - Fibre optic sensor: A sensor for measuring the concentration of an assay substance, such as oxygen in tissue. The sensor comprises an optical fibre (2) which passes through, a gas isolation collar (11) into a cavity (15) defined by a needle tube (13) attached to the gas isolation collar. Both the optical fibre... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090075320 - Method for screening an enhancer or a masker of salty taste: The invention relates to a nucleic acid molecule being represented by a nucleic acid sequence comprising at least three nucleic acid subsequences, each nucleic acid subsequence coding for one of the α, β, and γ subunits of the epithelial sodium channel, and each nucleic acid subsequence being arranged in a... Agent: Morgan Lewis & Bockius LLP

20090075322 - Method of analyzing various surface chemistries for culturing a given cell line: In one embodiment of the invention, there is provided a method of analyzing various surface chemistries for culturing a particular cell line, which includes the steps of: (1) providing a plasma polymerized surface having first and second regions, the first region including a first concentration of carboxylic acid groups in... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20090075323 - Static diffusion cell for diffusion sampling systems: A new design for a static diffusion cell for use in a diffusion sampling apparatus to be used in conjunction with automated or manual sampling is disclosed. The diffusion cell of present invention provides to an improved and efficient diffusion assay system.... Agent: Diehl Servilla LLC

20090075324 - Method and system for quantitative hemoglobin determination: A method for quantitative hemoglobin determination in undiluted, unhemolyzed whole blood is provided which comprises: acquiring a sample of unaltered whole blood into a capillary cuvette, presenting the cuvette to a set-up for an absorption measurement, delaying absorption measurement for a determined period of time, performing a first absorption measurement... Agent: Buchanan, Ingersoll & Rooney PC

20090075325 - Systems and methods for analyzing agricultural products: A method for analyzing agricultural products at a point of transaction is provided. The method comprises presenting a sample comprising at least one seed to a portable analysis system; analyzing the sample for at least one relevant attribute; and characterizing the sample for the transaction based upon the results of... Agent: Harness, Dickey & Pierce, P.L.C

20090075326 - Reproductive ablation constructs: The present invention relates to the regulation of reproductive development, particularly to the genetic ablation of reproductive tissues in angiosperm and gymnosperm species. Reproductive-preferred promoters, regulatory elements, and cytotoxic nucleotide sequences are disclosed herein, as are constructs and methods for genetic ablation.... Agent: Foley And Lardner LLP Suite 500

20090075327 - Methods for improving secondary metabolite production in fungi: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of... Agent: Fish & Richardson PC

20090075328 - Process for the overexpression of dehydrogenases: A process for the overexpression of dehydrogenases, especially for the overexpression of Δ1-dehydrogenases, in particular for the overexpression of 3-keto steroid-Δ1-dehydrogenases, as well as for the bacteria, plasmids and DNA sequences that can be used for the overexpression, is described.... Agent: Millen, White, Zelano & Branigan, P.C.

20090075329 - Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity: This invention provides novel chemically modified mutant serine hydrolases that catalyze a transamidation and/or a transpeptidation and/or a transesterification reaction. The modified serine hydrolases have one or more amino acid residues in a subsite replaced with a cysteine, wherein the cysteine is modified by replacing the thiol hydrogen in the... Agent: Genencor International, Inc. Attention: Legal Department

20090075331 - Industrial-scale serum-free production of recombinant proteins in mammalian cells: The invention relates to methods for cultivating mammalian cells and for producing recombinant proteins in large-scale cultures of such cells. The proteins are, e.g., Factor VII or Factor VII-related polypeptides.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20090075332 - Modified proteases: This invention relates to modified polynucleotides encoding modified proteases, and methods for altering the production of proteases in microorganisms. In particular, the present invention relates to methods for altering the expression of proteases in microorganisms, such as Bacillus species. The invention discloses modified polynucleotides, vectors, modified polypeptides, and processes for... Agent: Genencor International, Inc. Attention: Legal Department

20090075337 - Novel protein-deamidating enzyme, microorganism producing the same, gene encoding the same, production process therefor, and use thereof: A method for the production of an enzyme, which comprises culturing in a medium a strain that belongs to a bacterium classified into Cytophagales or Actinomycetes, or a new bacterium Chryseobacterium sp. No. 9670 belonging to the genus Chryseobacterium, and has the ability to produce an enzyme having a property... Agent: Edwards Angell Palmer & Dodge LLP

20090075334 - Polypeptides, their production and use: This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function, reproductive function, etc., it can be used as a drug for treating or preventing a variety of diseases, e.g. HIV infection or AIDS (acquired immune deficiency... Agent: Edwards Angell Palmer & Dodge LLP

20090075333 - Reduced genome e. coli: Reduced genome strains of E. coli MGl 655 are described. In various embodiments, the strains have one or more of equal or improved growth rate, transformation efficiency, protein expression, DNA production, DNA yield and/or DNA quality compared to the parental strain and commercially available strains.... Agent: Howrey LLP - Dc

20090075335 - Self-assembling protein hydrogel with bio-active protein: Protein hydrogel monomers incorporating bio-active proteins and methods for producing the same are provided. In some embodiments, the disclosed subject matter includes a protein hydrogel monomer including a bio-active protein and two alpha helices that are adapted to interact with alpha helices on other monomers to form coiled-coil junctions.... Agent: Baker Botts L.L.P.

20090075336 - Variant humicola grisea cbh1.1: Disclosed are variants of Humicola grisea Cel7A (CBH1.1), H. jecorina CBH1 variant or S. thermophilium CBH1, nucleic acids encoding the same and methods for producing the same. The variant cellulases have the amino acid sequence of a glycosyl hydrolase of family 7A wherein one or more amino acid residues are... Agent: Victoria L. Boyd Genencor International, Inc.

20090075330 - Xylanases with enhanced thermophilicity and alkalophilicity: The present invention provides a xylanase, or a modified xylanase enzyme comprising at least one substituted amino acid residue at a position selected from the group consisting of amino acid 11, 116, 118, 144 and 161, the position determined from sequence alignment of the modified xylanase with Trichoderma reesei xylanase... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090075339 - Autophilic antibodies: Autophilic antibodies including an immunoglobulin component and an autophilic peptide fused thereto are provided according to embodiments of the present invention. Particular autophilic antibodies described herein include a chimeric gamma immunoglobulin heavy chain and autophilic peptide expressed as a fusion protein. Preferably the autophilic peptide is expressed at the C-terminus... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20090075338 - Dimeric fusion proteins and materials and methods for producing them: Polypeptide fusions, dimeric fusion proteins, and materials and methods for making them are disclosed. One of the polypeptide fusions consists of a non-immunoglobulin polypeptide, a polypeptide linker, a dimerizing domain, and, optionally, a linking polypeptide. Another of the polypeptide fusions consists of a non-immunoglobulin polypeptide, a polypeptide linker, and a... Agent: Zymogenetics, Inc. Intellectual Property Department

20090075340 - Kir-binding agents and methods of use thereof: The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling without reducing the binding of KIR to HLA-C. As described herein, transduction of negative signaling via KIR, upon binding of KIR to its HLA class I ligand,... Agent: Novo Nordisk, Inc. Intellectual Property Department

20090075341 - Il-21 antagonists: Monoclonal antibodies are identified that bind the IL-21 protein. These antibodies are used to identify regions of the IL-21 protein to where binding neutralizes IL-21 activity. Hybridomas and methods of producing anti-IL-21 monoclonal antibodies are described. The monoclonal antibodies are useful in treating IL-21-mediated diseases, which may include autoimmune and... Agent: Zymogenetics, Inc. Intellectual Property Department

20090075342 - Metabolic profile directed aptamer medicinal chemistry: The present invention provides materials and methods for enhancing aptamers. More specifically, the materials and methods of the present invention are directed toward the modification of aptamers by the identification of one or more cleavage sites, and introduction of a chemical substitution at a position proximal to the cleavage site(s).... Agent: Mintz, Levin, Cohn, Ferris, Glovskyand Popeo, P.C.

20090075345 - Methods for genotyping with selective adaptor ligation: The present invention provides methods for reducing the complexity of a nucleic acid sample to interrogate a collection of target sequences. Complexity reduction can be accomplished by fragmenting the nucleic acid sample with a restriction enzyme that has at least one variable position in the recognition sequence. In some aspects... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20090075344 - Sample preparation apparatus: A reconfigurable sample preparation device includes a rotary plunger device having a hollow body and a coupling device, provided above one end of the rotary plunger, and accommodating a sample. The device also includes at least one sealed reagent module. When the rotary plunger is rotated on the coupling device,... Agent: Foley And Lardner LLP Suite 500

20090075343 - Selection of dna adaptor orientation by nicking: Aspects described and claimed herein provide methods to insert multiple DNA adaptors into a population of circular target DNAs at defined positions and orientations with respect to one another using nicking reactions. The resulting multi-adaptor constructs are then used in massively-parallel nucleic acid sequencing techniques.... Agent: Hensley Kim & Holzer, LLC

20090075346 - Starch-based biodegradable material composition: A starch-based biodegradable material composition includes: an enzyme-hydrolyzed starch; and a biodegradable polyester selected from at least one of an aliphatic polyester of polybutylene succinate and an aliphatic-aromatic copolyester. The enzyme-hydrolyzed starch is prepared by hydrolyzing a native starch using a starch-hydrolyzing enzyme. The starch-hydrolyzing enzyme has an activity unit... Agent: Nixon & Vanderhye, PC

20090075347 - Production of bacterial strains cross reference to related applications: The present invention provides methods to enhance production of desired products and increase the growth rate of a bacterial strain by inactivating an endogenous arcA and optionally overexpressing a ppc gene.... Agent: Lynn Marcus-wyner Genencor International, Inc.

20090075348 - Method for recovering a basic amino acid from a fermentation liquor: The invention relates to a method for recovering a basic amino acid from the fermentation liquor of a micro-organism strain that produces the basic amino acid. The method comprises the following steps: a) isolation of the micro-organisms from the fermentation liquor and b) separation of the basic amino acid from... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20090075349 - Method of recovering lipase activity: The present invention discloses a method of recovering lipase activity which comprises the steps of using a lipase derived from Thermomyces sp. and immobilized on a carrier, or a lipase powder composition which comprises a filter aid and the lipase derived from Thermomyces sp. and immobilized on a carrier which... Agent: Buchanan, Ingersoll & Rooney PC

20090075350 - Methods for producing alkyl esters: This invention relates to a method for producing an alkyl ester via a transesterification or esterification reaction. The method includes (1) mixing an oil source containing a triglyceride or a carboxylic acid and a first primary alcohol or a first secondary alcohol in a first organic solvent to form a... Agent: Occhiuti Rohlicek & Tsao, LLP

20090075351 - Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors: The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous nucleic acid encoding 4-hydroxybutanoate dehydrogenase, succinyl-CoA synthetase, CoA-dependent succinic semialdehyde dehydrogenase, or α-ketoglutarate decarboxylase, wherein the exogenous nucleic acid is expressed in sufficient amounts to produce... Agent: Mcdermott, Will & Emery

20090075352 - Method for improving a strain based on in-silico analysis: The present invention is related to a method for improving a strain on the basis of in silico analysis, in which it compares the genomic information of a target strain for producing a useful substance to the genomic information of a strain overproducing the useful substance so as to primarily... Agent: Intellectual Property / Technology Law

20090075353 - Method of producing bio-ethanol: A method of producing ethanol, which comprises of starch obtained from continuously cultivated unicellular green algae strains which reproduce through a single cell clone cultivation method that cyclically produces starch extra-cellularly. Only the starch is recovered and goes through a saccharification and fermentation process for the production of ethanol. The... Agent: Dobrusin & Thennisch PC

20090075354 - Nanofiber structures for supporting biological materials: The present invention relates generally to nanofiber structures designed to support, entrap, entangle, preserve, and/or retain one or more biological materials. More specifically, the present invention relates to nanofiber matrix structures made from at least two different types of nanofibers that are designed to support, entrap, entangle, preserve, and/or retain... Agent: Roetzel And Andress

20090075355 - Human serum for cell culture: It is intended to provide a serum which contains a large amount of growth factors capable of efficiently promoting the growth of stem cells. A human serum for cell culture which shows a residual ratio of platelets remaining within 20 minutes after blood collection in relation to the whole amount... Agent: International Knowledge Asset Office

20090075356 - Pullulanase variants and methods for preparing such variants with predetermined properties: The present invention relates to pullulanase variants, wherein the variants have improved properties, for example, altered pH optimum, improved thermostability, altered substrate specificity, increased specific activity or altered cleavage pattern.... Agent: Novozymes North America, Inc.

20090075357 - Production of recombinant aav virions: Stocks of infectious rAAV are generated using yeast strains, bacterial strains, and bacteriophages engineered to express the required AAV proteins and harboring rAAV vector sequences. Stocks of rAAV virions of all serotypes and pseudotypes can be generated in prokaryotic and eukaryotic cells using the methods described herein.... Agent: Akerman Senterfitt

20090075358 - Vectors for transformation of plant cells: Vectors for transformation of plants contain a minimum set of transfer machinery genes, such as vir genes from Agrobacterium Ti plasmids or tra genes.... Agent: Carol Nottenburg

20090075359 - Apparatus and method for encapsulating pancreatic cells: An apparatus and method for coating micron-sized or sub-micron-sized particles such as living cells. The coating apparatus includes an encapsulation chamber enclosing a two-layer water-oil system for coating each islet cell with an aqueous polymeric coat. Islets together with an aqueous polymer solution are fed by a feed device that... Agent: Mark D. Swanson Pauley Petersen & Erickson

20090075360 - Apparatus and methods for manipulation and optimization of biological systems: The invention provides systems and methods for manipulating, e.g., optimizing and controlling, biological systems, e.g., for eliciting a more desired biological response of biological sample, such as a tissue, organ, and/or a cell. In one aspect, systems and methods of the invention operate by efficiently searching through a large parametric... Agent: Morrison & Foerster LLP

20090075361 - Microfluidic device and method of manufacturing the microfluidic device: A microfluidic device having a substrate with an array of curvilinear cavities. The substrate of the microfluidic device is preferably fabricated of a polymer such as polydimethylsiloxane (PDMS). The microfluidic device is manufactured using a gas expansion molding (GEM) technique.... Agent: Bond, Schoeneck & King, PLLC

20090075363 - Cell culture container and method of producing the same: To provide a cell culture chamber capable of reproducing a cell function in vivo, and a method of producing the same. The cell culture chamber according to the present invention has a concave-convex pattern formed on the surface on which cells are cultured. A concave portion of the concave-convex pattern... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090075362 - Disposable bioreactor comprising a sensor arrangement: The invention relates to a disposable bioreactor comprising a reversible, externally attachable sensor arrangement for measuring a physical variable of a contained medium. A sensor adapter (28) for receiving an electronic sensor arrangement (34, 38; 42; 44a, 44b, 46, 48) interacting with the medium cross-flowing the peripheral lines (14, 16,... Agent: Casella & Hespos

20090075364 - System for mixing high viscous liquids with gas: A system and method for mixing high viscous liquids with gas is provided. The disclosed embodiments include a reactor or mixing vessel having a draft tube disposed therein, a gas injection subsystem adapted to inject gas into the reactor or mixing vessel proximate the entrance of the draft tube. The... Agent: Praxair, Inc. Law Department - M1 557

20090075365 - Culture device: A culture device containing a culture vessel for culturing a cell, in which the culture device includes a thermostatic vessel having a stacker containing a plurality of culture vessels for culturing a cell, and an observation portion arranged to be isolated from an atmosphere at inside of the thermostatic vessel... Agent: Oliff & Berridge, PLC

20090075366 - Cell culture chamber: It is intended to provide a cell culture chamber in a shape suitable for cell culture. It is also intended to provide a cell culture chamber which is inexpensive and facilitates observation. A cell culture chamber (100) includes a cover (10), a chamber body (20) and a plate-shaped base (30).... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090075367 - Systems and methods for storing and monitoring, and for evaluating and ensuring the quality of cord blood: Processes and systems are provided for tracking, monitoring, receiving, documenting, and reporting conditions of a client's cord blood sample from collection through to storage. Processes and systems are provided for collecting or receiving data relating to the cord blood sample and reporting the data. The data may comprise procurement data,... Agent: Dilworth Paxson LLP

20090075369 - Angiostatin fragments and method of use: Fragments of an endothelial cell proliferation inhibitor and method of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin fragment. The angiostatin fragments generally correspond to kringle structures occurring within the endothelial cell proliferation inhibitor. The endothelial cell inhibiting... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20090075368 - Outer membrane protein of ehrlichia canis and ehrlichia chaffeensis: Diagnostic tools for serodiagnosing ehrlichiosis in mammals, particularly in members of the Canidae family and in humans are provided. The diagnostic tools are a group of outer membrane proteins of E. chaffeensis and variants thereof, referred to hereinafter as the “OMP proteins”, a group of outer membrane proteins of E.... Agent: Calfee Halter & Griswold, LLP

20090075370 - Vectors: The present invention relates to a polynucleotide comprising a nucleotide sequence encoding a retroviral gag protein, wherein the gag protein comprises a heterologous RNA binding domain capable of recognising a corresponding sequence in an RNA genome to facilitate packaging of the RNA genome into a retroviral vector particle.... Agent: Frommer Lawrence & Haug

20090075371 - Regenerative medicine devices and foam methods of manufacture: The invention relates generally to devices for organ replacement and regenerative medicine providing a biocompatible and biodegradable scaffold capable of integral cell growth that forms a hollow chamber, as well as methods for producing such devices by lyophilizing biocompatible, biodegradable polymers to produce a seamless, three-dimensional shape.... Agent: Philip S. Johnson Johnson & Johnson

20090075372 - Obtention of food- or auto-antigen specific tr1 cells from a leukocyte or pbmc population: An in vitro method for the obtention of a food- or auto-antigen specific Tr1 cell population from a leukocyte or a PBMC population, includes stimulating the PBMC or leukocyte population with the food- or auto-antigen, and recovering the food- or auto-antigen specific Tr1 cell population from the stimulated cell population.... Agent: Young & Thompson

20090075374 - Methods of generating epithelial lineage cells from embryoid bodies and pluripotent cells: Methods of generating p63-positive cells from embryoid bodies and pluripotent cells by culturing the cells in the presence of a retinoid and optionally a bone morphogenetic protein, such that the cells express at least p63. The p63-positive cells can be further cultured without the retinoid and optional bone morphogenetic protein... Agent: Quarles & Brady LLP

20090075373 - Neural progenitor cells derived from embryonic stem cells: This invention provides methods that generate in vitro and in vivo models of controlled differentiation of ES cells towards the neural lineage. The model, and cells that are generated along the pathway of neural differentiation may be used for: the study of the cellular and molecular biology of human neural... Agent: Scully, Scott, Murphy & Presser

20090075375 - Choroid plexus preparation and uses thereof: The present invention is directed to the use of choroids plexus cells and/or choroids plexus conditioned media for enhancing the growth, survival and/or maintenance of function of non-choroid plexus cells grown in long term or short term culture.... Agent: Greenlee Winner And Sullivan P C

20090075376 - Methods of inhibiting tumor cell proliferation with foxm1 sirna: The invention provides methods for inhibiting tumor cell proliferation by inhibiting Fox M1B (also called Fox M1) activity in a tumor cell. The invention also provides FoxM1B siRNA molecules and pharmaceutical compositions comprising FoxM1B siRNA molecules, wherein the siRNA molecules can inhibit FoxM1B activity and can inhibit proliferation of tumor... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090075379 - Modulation of homologous recombination with single stranded dna binding proteins: In one aspect of the invention, single stranded DNA binding proteins (SSB) may be used to modulate homologous recombination in mitosis or meiosis. method are provided for modulating homologous recombination comprising transforming a cell with a nucleic acid encoding a single stranded DNA binding protein; and, allowing the cell to... Agent: Knobbe Martens Olson & Bear LLP

20090075377 - Molecular interactions in cells: The invention provides reagents and methods for inhibiting or enhancing interactions between proteins in cells, particularly interactions between a PDZ protein and a PL protein. Reagents and methods that are provided are useful for treatment of a variety of diseases and conditions in a variety of cell types.... Agent: Townsend And Townsend And Crew, LLP

20090075378 - Somatic hypermutation systems: The present application relates to somatic hypermutation (SHM) systems and synthetic genes. Synthetic genes can be designed using computer-based approaches to increase or decrease susceptibility of a polynucleotide to somatic hypermutation. Genes of interest are inserted into the vectors and subjected to activation-induced cytidine deaminase to induce somatic hypermutation. Proteins... Agent: Wilson Sonsini Goodrich & Rosati

20090075381 - Amnion-derived cell compositions, methods of making and uses thereof: The invention is directed to substantially purified amnion-derived cell populations, compositions comprising the substantially purified amnion-derived cell populations, and to methods of creating such substantially purified amnion-derived cell populations, as well as methods of use. The invention is further directed to antibodies, in particular, monoclonal antibodies, that bind to amnion-derived... Agent: Linda O. Palladino

20090075380 - Methods and compositions to enhance efficiency of nuclear transfer/cloning: The present invention provides compositions and methods for increasing the success of assisted reproductive technology (ART). Specifically, the inventions described herein increase the survival rate of manipulated embryos for increasing post implantation numbers of viable offspring. In particular, the present invention provides for compositions and methods for allowing further embryonic... Agent: Peter G. Carroll Medlen & Carroll, LLP

20090075382 - Fibre-reinforced scaffold: The invention provides a fibre-reinforced scaffold for tissue engineering. The scaffold comprises a matrix comprising a biocompatible polymer, the matrix having a, porous structure; and discrete, macroscopic fibres embedded within the matrix, wherein the fibres are oriented such that at least one mechanical property of the scaffold is anisotropic. The... Agent: Sand & Sebolt

20090075383 - Composition and method for efficient delivery of nucleic acids to cells using chitosan: There is disclosed a composition and a method for the efficient non-viral delivery of nucleic acids to cells using chitosan. In order to achieve high efficiency of transfection, the composition contains a nucleic acid and a chitosan that has the following physico-chemical properties: a combination of a number-average molecular weight... Agent: David S. Resnick

20090075384 - Promoterless cassettes for expression of alphavirus structural proteins: The present invention provides an isolated RNA molecule comprising: a) an alphavirus 5′ replication recognition sequence, wherein at least one initiation codon has been removed from the 5′ replication recognition sequence; b) a nucleotide sequence encoding an alphavirus structural protein; and c) an alphavirus 3′ replication recognition sequence, with the... Agent: Myers Bigel Sibley & Sajovec

  
03/12/2009 > patent applications in patent subcategories. listing by industry category

20090068634 - Substrates and internal standards for mass spectrometry detection: An inventive substrate is provided which includes a substrate compound of formula A-B1—B2—B3: wherein A is a sugar moiety; B1 is a linker moiety allowing the conjugation of moiety A and the remaining structure of the substrate; B2 contains a permanently charged element such as a quaternary ammonium group so... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

20090068635 - Indirectly labelled assay conjugates and methods of preparing and using same: Indirectly labelled assay conjugates prepared by a method that includes the step of submitting the binding member comprised by the conjugate to denaturing conditions prior to labelling the binding member. The indirectly labelled assay conjugates demonstrate an increased sensitivity when employed in diagnostic assays compared to assay conjugates prepared by... Agent: Paul D. Yasger Abbott Laboratories

20090068640 - Methods for detecting and inactivating a prion: A method for the isolation or detection of a prion in a sample is disclosed. Also disclosed are methods for the disinfection and/or decontamination and/or inactivation of TSE infectivity.... Agent: Millen, White, Zelano & Branigan, P.C.

20090068637 - Monoclonal antibodies binding to avian influenza virus subtype h5 haemagglutinin and use thereof: The present application provides monoclonal antibodies that specifically bind to the hemagglutinin of avian influenza virus subtype H5, as well as monoclonal antibodies capable of blocking at least 50% of the hemagglutinin binding activity of these monoclonal antibodies. Such antibodies are useful, for example, in the detection, diagnosis, prevention, and... Agent: Perkins Coie LLP

20090068638 - Phage-based method for the detection of bacteria: The present invention relates to the field of biosensors useful for detecting bacteria. More particularly, the present invention relates to an electrochemical cell or biosensor and its use in a phage-based method and kit for the detection of bacteria.... Agent: Robic

20090068639 - System and method of quantitatively determining a biomolecule, system and method of detecting and separating a cell by flow cytometry, and fluorescent silica particles for use in the same, and kit comprising plural kinds of the silica particles in combina: A system of quantitatively determining a biomolecule, which has: allowing fluorescent silica particles capable of emitting fluorescence detectable by a flow cytometer to capture a target biomolecule fluorescent-labelled for quantitative determination; detecting the fluorescence emitted from the fluorescent silica particles themselves by using the flow cytometer; and measuring the intensity... Agent: Birch Stewart Kolasch & Birch

20090068636 - Viral protein: The present invention is directed to an isolated polypeptide containing SEQ ID NO: 1 or an immunogenic fragment thereof. Also disclosed is an isolated nucleic acid encoding the polypeptide or containing a sequence at least 70% identical to SEQ ID NO: 3. Within the scope of this invention are related... Agent: Howrey LLP-ca

20090068664 - Amplification methods and compositions: The present invention provides methods and routines for developing and optimizing nucleic acid detection assays for use in basic research, clinical research, and for the development of clinical detection assays. In particular, the present invention provides methods for designing oligonucleotide primers to be used in multiplex amplification reactions. The present... Agent: Casimir Jones, S.c.

20090068654 - Assay for identifying compounds which affect stability of mrna: The present invention relates to an assay for the identification of biologically active compounds, in particular to a reporter gene assay for the identification of compounds, which have an effect on mRNA stability. More particularly, the present invention relates to a reporter gene expression system and cell lines comprising said... Agent: Morrison & Foerster LLP

20090068671 - Binding method and apparatus for sorting objects: The present invention relates to a method and apparatus of sorting objects including, providing a sample having wanted objects and unwanted objects; coating a surface of a sample holder with an antibody; placing an eluted sample on the sample holder; binding an antigen in the wanted objects with the antibody... Agent: Akerman Senterfitt

20090068653 - Biochemical and genetic analysis for prediction of breast cancer risk: The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of three selected genes, here associated with specific biochemical activities, to identify individuals with increased or decreased risk of breast cancer. Using such methods, it is possible to reallocate... Agent: Fulbright & Jaworski L.L.P.

20090068655 - Composition and method for nucleic acid sequencing: The present invention provides compositions and methods for detecting incorporation of a labeled nucleotide triphosphate onto the growing end of a primer nucleic acid molecule. The method is used, for example, to genotype and sequence a nucleic acid. In a preferred embodiment, the method described herein detects individual NTP molecules.... Agent: Townsend And Townsend And Crew, LLP

20090068642 - Composition and pharmacology of novel alpha6-containing nicotinic acetylcholine receptors: Nicotinic acetylcholine receptors (nAChRs) comprising the α6 receptor subunit; nucleic acids, including vectors, comprising subunit incoding sequences; cells expressing the nAChRs of the invention; and methods of screening compounds are provided.... Agent: Womble Carlyle Sandridge & Rice, PLLC

20090068672 - Detection system: The use of a red nucleic acid stain, in particular red fluorescent SYTO® dye in various methods used for the detection or characterisation of nucleic acids is described. In particular, the red nucleic acid stains have been found to be particularly compatible with the polymerase chain reaction (PCR), and therefore... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20090068647 - Dna sequences for the detection of and differentiation amongst pathogenic e.coli: Oligonucleotide sequences and methods for specifically detecting and differentiating amongst pathogenic E. coli in a complex sample. The complex sample can be a food sample, water sample, or selectively enriched food matrix. The methods of detection may utilize PCR amplification with, or without, an internal positive control, and appropriate primer... Agent: Joung, J Kenneth E.i.du Pont De Nemours And Company

20090068643 - Dual function primers for amplifying dna and methods of use: The present invention provides novel nucleotide compositions that enable the detection of DNA synthesis products and methods for use thereof. In one embodiment, the method can be used in PCR and allows the progress of the reaction to be monitored as it occurs. In one embodiment, the invention employs at... Agent: John Petravich Integrated Dna Technologies, Inc.

20090068641 - Highly conserved genes and their use to generate probes and primers for detection of microorganisms: Four highly conserved genes, encoding translation elongation factor Tu, translation elongation factor G, the catalytic subunit of proton-translocating ATPase and the RecA recombinase, are used to generate species-specific, genus-specific, family-specific, group-specific and universal nucleic acid probes and amplification primers to rapidly detect and identify algal, archaeal, bacterial, fungal and parasitical... Agent: Knobbe Martens Olson & Bear LLP

20090068645 - Labeling and sequencing of nucleic acids: The invention provides for methods of end labelling a ds DNA molecule with a bar-code as well as adaptor mediated methodology for creating single stranded overhanging ends, lengthening single stranded overhanging ends, controlled size reduction of labelled ds DNA molecules, and adaptor mediated sequencing. Also disclosed are methods for parallel... Agent: Clark & Elbing LLP

20090068650 - Metabolic primers for the detection of (per) chlorate-reducing bacteria and methods of use thereof: The present invention is directed to metabolic primers for the detection of (per)chlorate-reducing bacteria and methods and compositions for use of the same in environmental bioremediation.... Agent: Marshall, Gerstein & Borun LLP

20090068674 - Method and device for preparing a sample of biological origin in order to determine at least one constituent contained therein: The invention relates to a method of preparing an original sample (3) of biological origin with a view to detecting at least one component contained in it, whereby the original sample (3) is enclosed in a first container (1) and at least a part of this original sample (3) is... Agent: Collard & Roe, P.C.

20090068648 - Method and system for determining a quality metric for comparative genomic hybridization experimental results: Various embodiments of the present invention determine various quality metrics that reflect the quality of two or more identically-executed or similar array-based comparative-genomic-hybridization (“aCGH”) experiments. In certain embodiments of the present invention, a pairwise quality metric is generated for each possible pair of aCGH experimental results within a set of... Agent: Agilent Technologies, Inc. Legal Department, Dl429

20090068662 - Method and test kit for the separation, purification and recycling of long- and short-chain nucleic acids: Long- and/or short-chain nucleic acids are separated, purified and recovered by binding the nucleic acid to a solid phase using a binding buffer, to obtain a bonded nucleic acid, and eluting of the bonded nucleic acid from the solid phase, wherein the binding buffer comprises at least one citric acid... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090068652 - Method for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule: The invention relates to methods for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule. The method involves cleaving a double-stranded nucleic acid molecule containing a mismatch with a mismatch-specific endonuclease which cleaves on the 3′ side of the mismatch, and preserving the integrity of... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20090068659 - Method for identifying the sequence of one or more variant nucleotides in a nucleic acid molecule: The invention relates to methods for identifying the sequence of one or more variant nucleotides in nucleic acid molecules. The method involves cleaving a double-stranded nucleic acid molecule containing a mismatch with a mismatch-specific endonuclease which cleaves on the 3′ side of the mismatch, and preserving the integrity of the... Agent: Licata & Tyrrell P.C.

20090068644 - Method for producing highly sensitive endonucleases, novel preparations of endonucleases and uses thereof: The present invention pertains to methods for producing recombinant endonucleases having a high sensitivity, as well as to endonucleases preparations obtained by said methods, and uses thereof, especially for the detection of mismatches.... Agent: Alston & Bird LLP

20090068651 - Method for the detection of the antibiotic resistance spectrum of mycobacterium species: Method for the detection of the antibiotic resistance spectrum of Mycobacterium species present in a sample, possibly coupled to the identification of the Micobacterium species involved, comprising the steps of: (i) if need be releasing, isolating or concentrating the polynucleic acids present in the sample; (ii) if need be amplifying... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090068657 - Method of predicting the clinical response to cisplatin or carboplatin chemotherapeutic treatment: Method for predicting the survival of a patient suffering from NSCLC to a cisplatin or carboplatin based chemotherapy treatment which comprises the step of determining the methylation state of a nucleic acid encoding 14-3-3 sigma in a biological sample from the patient, wherein the presence of methylation is indicative of... Agent: Intellectual Property / Technology Law

20090068667 - Methods and assays for screening stem cells: The present invention provides methods and assays for screening cells, such as stem cells, for chromosomal aberrations. In particular, the present invention provides a rapid, sensitive assay platform for detecting high and low levels of chromosomal aberrations present in a cell population. This includes, but is not limited to, detection... Agent: Casimir Jones, S.c.

20090068646 - Methods and kits for detecting mutations: Disclosed are methods and kits for detecting mutations in DNA by comparing the size of an amplified microsatellite locus to the expected size. The methods and kits may used in various applications, including monitoring exposure of a cell or organism to a mutagen, evaluating the mutagenicity of an agent, and... Agent: Michael Best & Friedrich LLP

20090068665 - Methods and kits for identifying target nucleotides in mixed populations: Ligation-based methods and kits are disclosed for identifying at least two target nucleotides in a mixed population sample that is a sample that contains or potentially contains target nucleic acid sequences from more than one source. Typically, two ligation reaction compositions are formed ligation products generated, and the ligation products... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090068675 - Methods for improved diagnosis of dysplasias: The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without... Agent: Fitzpatrick Cella Harper & Scinto

20090068656 - Methods of diagnosing osteoarthritis: A method of diagnosing osteoarthritis in a mammal is provided comprising the steps of obtaining a biological sample from the mammal; and quantifying in the sample the expression of at least one chondrocyte-specific gene or gene product, wherein a differential in expression of said gene or gene product in comparison... Agent: Valentine A Cottrill Susan Tandan

20090068649 - Methods of dna methylation detection: Two methods are described, direct and indirect detection of methylated DNA molecules in a nano transistor based device. In the direct detection, methylated target DNA molecules are captured on the sensing surface resulting in changes in the electrical properties of a nano transistor. These changes generate detectable electronic signals. In... Agent: Technology Law Group, PLLC

20090068661 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20090068663 - Screening methods and sequences relating thereto: p

20090068669 - Slc9a3r1 directed diagnostics for neoplastic disease: Disclosed are methods for diagnosing cancer in a test cell sample or fluid sample by detecting an increase in the level of expression of SLC9A3R1 in the test cell sample or fluid sample as compared to the level of expression of SLC9A3R1 in a control cell sample or fluid sample... Agent: Wilmerhale/boston

20090068658 - Soybean mutant strain and soybean oil therefrom: A soybean oil of a decreased content of polyunsaturated fatty acids is produced by hybridizing, selecting and raising a soybean mutant KK21 characterized by a gene having a sequence of base given by the sequence No. 1 of the sequence listing, a soybean mutant M23 characterized by deletion of a... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090068670 - Stratifin directed diagnostics for neoplastic disease: Disclosed are methods for diagnosing cancer in a test cell sample or fluid sample by detecting an increase in the level of expression of stratifin in the test cell sample or fluid sample as compared to the level of expression of stratifin in a control cell sample or fluid sample... Agent: Wilmerhale/boston

20090068666 - Systems and methods for determining an amount of starting reagent using the polymerase chain reaction: Systems and methods for calculating an initial amount of target nucleic acid N0 in a sample are provided. A plurality of fluorescent measurements is received. Each respective fluorescent measurement FSn is taken in a different cycle n in a PCR amplification experiment of the sample. Then, a model for the... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20090068660 - Use of methylated or unmethylated line-1 dna as a cancer marker: The invention relates to a method of detecting LINE-1 (long interspersed nucleotide elements-1) DNA either methylated or unmethylated at the promoter region in a tissue or body fluid sample from a subject. Also disclosed are methods of using LINE-1 DNA as a biomarker for diagnosing, predicting, and monitoring cancer progression... Agent: Hogan & Hartson L.L.P.

20090068673 - Utilization of compatible solutes to improve the performance of the techniques using immobilized biologic materials: This invention is based upon the application of compatible solutes to immobilized biological materials or to immobilize in order to improve the technical performance using the same, namely nucleic acid and proteins or biosensors micronets. The above mentioned compatible solutes are selected from a group that includes Mannosylglycerate (MG) and... Agent: Sughrue Mion, PLLC

20090068668 - Waveguide-based optical scanning systems: A scanning sensor system, methods of use and kits for detecting a biologically active analyte are provided. The scanning sensor system includes a light source, a detector, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of... Agent: Wilson Sonsini Goodrich & Rosati

20090068679 - Binding partners of the placental growth factor, especially antibodies directed against the placental growth factor, and production and use thereof: The invention relates to binding partners of the placental growth factor (or placenta growth factor, PIGF), especially antibodies directed against the placental growth factor, and production and use thereof.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090068677 - Biomarker for diagnosing heart disease and the use thereof: [3] A method for detecting severity of heart disease, characterized in that the method comprises determining a free immunoglobulin kappa light chain level and/or a free immunoglobulin lambda light chain level of a specimen and comparing at least one value of the kappa chain level, the lambda chain level, and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090068676 - Diagnostic methods for congestive heart failure: The invention provides an assay for the quantification of circulating glycophorin in biological fluid samples. The circulating glycophorin measured by this assay is a truncated glycophorin diagnostic for congestive heart failure (CHF).... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20090068680 - Method for characterizing immune disorders: Methods for characterizing immune diseases are provided which include exposing a sample of biological fluid from a patient to a pooled population of particles, wherein a first subset of particles is bound to a reactant that binds an antibody and a second subset of particles is bound to a reactant... Agent: Daffer Mcdaniel LLP

20090068678 - Method for identifying modulators of noah10 useful for treating alzheimer's disease: Methods for identifying modulators of NOAH10 are described. The methods are particularly useful for identifying analytes that antagonize NOAH10's effect on processing of amyloid precursor protein (APP) to amyloid beta (Aβ) peptide and are useful for identifying analytes that can be used for treating Alzheimer disease.... Agent: Merck And Co., Inc

20090068681 - Methods and compositions for risk stratification: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20090068683 - Markers for preeclampsia: This document provides methods and materials related to determining whether or not a pregnant mammal (e.g., a pregnant human) has preeclampsia. For example, methods and materials related to the use of urinary podocytes to determine whether or not a pregnant human has preeclampsia are provided.... Agent: Fish & Richardson P.C.

20090068685 - Method of identifying biomarkers in human serum indicative of pathologies of human lung tissues: A method of identifying altered biomarker expression levels in a human serum specimen to diagnose asthma or non-small celled lung cancers in humans. The existence of asthma or non-small celled lung cancers in a patient can be determined by subjecting a blood sample from the patient to a simple blood... Agent: Gunn & Lee, P.C.

20090068684 - Serine and threoninephosphorylation sites: The invention discloses 345 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Simona Levi-minzi, Ph.d. General Counsel

20090068686 - Method for diagnosing auto-immune chronic urticaria: In certain embodiments, the present invention relates to methods, compositions, and kits for diagnosing autoimmune chronic urticaria. For example, in certain embodiments, such methods generally comprise detecting the presence of auto-antibodies to cell-surface IgE receptors or cell-bound IgE in a patient. Such auto-antibodies may be detected by (a) obtaining donor... Agent: Bryan Cave LLP

20090068682 - Immunological assay for plasmin-digested products of stabilized fibrin: A method of immunologically analyzing plasmin-digested products of stabilized fibrin, characterized by using a combination of a monoclonal antibody (a) which does not react with stabilized fibrin, fibrinogen, and plasmin-digested products of fibrinogen, but reacts with a neoantigen which is newly exposed in a D domain by digesting stabilized fibrin... Agent: Heslin Rothenberg Farley & Mesiti PC

20090068691 - Endothelial-monocyte activating polypeptide ii, a biomarker for use in diagnosis and treatment of brain injury: A diagnostic tool and method of diagnosing brain injury and brain injury type (traumatic vs. ischemic) by detecting the level of expression of endothelial monocyte-activating polypeptide II (EMAP-II) and comparing to a control. An increase of EMAP-II indicates the presence of traumatic brain injury and a decrease of EMAP-II indicates... Agent: Caroline Nash Nash & Titus, LLC

20090068690 - Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor: Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods... Agent: Alston & Bird LLP

20090068689 - Molecular phenotyping of severe asthma: The present invention discloses a method for classifying individuals into those who have airway hyperreactvitiy and those with asthma based on cytokine expression patterns. It is contemplated that such a method will enable rapid identification of individuals requiring intensive treatment for asthma, thereby reducing morbidity and improving quality of life... Agent: Benjamin Aaron Adler Adler & Associates

20090068688 - Pvdf membranes: The invention provides a method of treating a polyvinyl difluoride (PVDF) membrane comprising: (a) contacting said membrane with an alcohol and a wetting agent; and (b) drying said membrane.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090068687 - Screening platform for discovery of immunomodulatory activities in traditional medicine: The present invention relates to a method of screening traditional medicines for immunomodulating activity and anti-tumor activity. The method involves applying techniques and tools used in the field of proteomics, isolating an active ingredient from a natural ingredient historically used as a traditional medicine, stimulating splenocytes, and measuring and determining... Agent: Attn: Maquita Wong The Hong Kong Polytechnic University

20090068692 - Marker for prolonged rupture of membranes: The present invention relates to amniotic fluid specific polypeptide and a method for detecting rupture of the amniotic membranes. In particular the invention provides a marker for prolonged rupture of the membranes (PROM), which marker consists essentially of polypeptides of approximately 75 kDa, 20 kDa and 50 kDa as determined... Agent: Alston & Bird LLP

20090068694 - Enzyme activity measurements using bio-layer interferometry: Disclosed are enzyme assays using biolayer interferometry. Assays may be carried out using immobilized substrate or with a substrate capture format. In certain embodiments, the assays are carried out using unlabeled substrates. The methods are broadly applicable to enzyme assay measurements, can be carried out in vivo or in vitro,... Agent: Fenwick & West LLP

20090068693 - High sensitivity assay for detection of nucleoside diphosphate production: The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as part of a number of methods for identifying candidate agents that bind to a target protein or... Agent: Townsend And Townsend And Crew, LLP

20090068695 - Sir2 products and activities: A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-acetyl-ADP-ribose, which is the newly discovered product of the reaction of Sir2 enzymes with acetylated peptides and NAD+. Analogs of 2′/3′-O-acetyl-ADP-ribose are also provided. Additionally,... Agent: Amster, Rothstein & Ebenstein LLP

20090068696 - Compositions and means for diagnosing microbial infections: n

20090068697 - Compounds and methods of use thereof for assaying lysophospholipase d activity: Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to... Agent: The Mccallum Law Firm, P. C.

20090068698 - Pregnancy-related enzyme activity: This invention relates to the role of the enzyme proprotein convertase 5/6 in pregnancy, and in particular to the detection or modulation of proprotein convertase 5/6 and its isoforms in the uterus. This enzyme is useful in the control of fertility, the monitoring of early pregnancy, and for the detection... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20090068700 - Device and methods for monitoring the status of at least one cell: A device and methods for monitoring status of at least one cell, wherein the cell has a membrane forming a substantially enclosed structure and defining an intracellular space therein. In one embodiment of the present invention, the device includes a first substrate having a first surface and an opposite second... Agent: Morris Manning Martin LLP

20090068701 - Systems and methods for screening pharmaceutical chemicals: A method for obtaining a response of a tissue model system to an activator includes contacting a bio-artificial tissue model system with an activator and measuring cellular mechanical response thereto of at least one of contractile force and tissue stiffness. A method for obtaining a response of a tissue model... Agent: Michael Best & Friedrich LLP

20090068699 - Use of glutaminyl cyclase inhibitors: m

20090068702 - Method for producing a mucin-type glycoprotein: The present invention relates to a means for generating a mucin-type glycopeptide or glycoprotein on a large scale in yeast. Specifically, the invention relates to a method which comprises introducing into a yeast at least one selected from the group consisting of a gene encoding UDP-GalNAc synthetase, a gene encoding... Agent: Foley And Lardner LLP Suite 500

20090068703 - Protein expression systems: Disclosed are recombinant non-insect host cells and use of activation of CMV or SV40 promoters by IE1, IE2 and the enhancer hr of the baculovirus in non-insect host cells for expression heterologous RNAs or polypeptides. Also disclosed are methods of using the cells.... Agent: Occhiuti Rohlicek & Tsao, LLP

20090068704 - Utilization of starch for biological production by fermentation: This invention relates to a method for utilizing less purified starch in fermentation processes. One example is a recombinant E. coli containing a exogenous extracellular isoamylase activity that is capable of utilizing small oligomers containing (1,6) linkages (including but not limited to isomaltose and panose) in fermentations to produce useful... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090068705 - Use of copper glutamate in cell culture for production of polypeptides: An improved system for large scale production of polypeptides in cell culture is provided. In accordance with the present invention, cells expressing a polypeptide of interest are grown in media that contain copper, glutamate or both. The use of such a system allows production of polypeptides in which misfolding and/or... Agent: Choate, Hall & Stewart LLP/wyeth

20090068706 - Production of highly isotopically labelled, secondary, microbial metabolic products, and corresponding metabolic products: The invention relates to a method for producing isotopically labelled secondary metabolic products of fungi or bacteria in a liquid synthetic culture medium. According to said method, the synthesis is carried out by immobilizing the fungi or bacteria on an inert carrier, adding a liquid synthetic culture medium in which... Agent: Jacobson Holman PLLC

20090068707 - Plasmid dna preparations and methods for producing same: The various embodiments of the present invention relate generally to plasmid DNA preparations and to methods for producing and using such preparations.... Agent: Howrey LLP - Dc

20090068708 - Method for molecular cloning and polynucleotide synthesis using vaccinia dna topoisomerase: e

20090068709 - Global amplification using a randomly primed composite primer: The invention relates to the field of polynucleotide amplification. More particularly, the invention provides methods, compositions and kits for amplification of (i.e., making multiple copies of) a multiplicity of different polynucleotide template sequences using a randomly primed RNA/DNA composite primer.... Agent: Wilson Sonsini Goodrich & Rosati

20090068710 - Complex crystalline sugar comprising d-psicose and d-allose and process for production of the same: A complex crystalline sugar comprising D-psicose and D-allose. The compositional ratio between D-psicose and D-allose in the sugar is about 1:1 to 1:4. A process for producing a complex crystalline sugar comprising D-psicose and D-allose, the process comprising producing a complex crystalline sugar comprising D-psicose and D-allose from a sugar... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20090068711 - Method for the production of l-amino acids using strains from the enterobacteriacea family: The invention relates to a method for the production of L-amino acids by fermentation of recombinant microorganisms of the Enterobacteriaceae family, characterized in that a) the microorganisms producing the desired L-amino acid and wherein the lamB-gene or nucleotide sequence coding for the gene product maltoporin is amplified, particularly overexpressed, are... Agent: Law Office Of Michael A. Sanzo, LLC

20090068712 - Amino acid producing microorganism and a method for producing an amino acid: A microorganism is provided which has an ability to produce an L-amino acid such as L-lysine, L-tryptophan, L-phenylalanine, L-valine, L-leucine, L-isoleucine and L-serine, and has been modified to increase the activity of pyruvate synthase or pyruvate:NADP+ oxidoreductase. This microorganism is cultured in a medium containing ethanol or an aliphatic acid... Agent: Cermak & Kenealy LLP Acs LLC

20090068713 - Process for producing gamma-glutamylamide compounds: The present invention provides a process for producing a γ-glutamylamide compound, which comprises forming the γ-glutamylamide compound from a glutamyl donor and an amine compound using γ-glutamylcysteine synthetase, preferably γ-glutamylcysteine synthetase derived from a microorganism, or a culture of cells having the enzyme or a treated culture as an enzyme... Agent: Fitzpatrick Cella Harper & Scinto

20090068714 - Systems and methods for producing biofuels and related materials: Clostridium phytofermentans cells (American Type Culture Collection 700394T) and all other strains of the species can ferment materials such as biomass into useful products and coproducts, such as ethanol, hydrogen and organic acids. Compositions that include Clostridium phytofermentans are also disclosed.... Agent: Fish & Richardson PC

20090068715 - Method of producing bio-ethanol: A method of producing ethanol, which comprises of starch obtained from continuously cultivated unicellular green algae strains which reproduce through a single cell clone cultivation method that cyclically produces starch extra-cellularly. Only the starch is recovered and goes through a saccharification and fermentation process for the production of ethanol. The... Agent: Dobrusin & Thennisch PC

20090068716 - Biological indicator and method for producing the same: A biological indicator including a carrier and an indicator material, said indicator material adhering on the surface of the carrier, and having a contact portion being contact with the surface of the carrier and a non-contact portion being not in contact with the surface of the carrier, and wherein the... Agent: Oliff & Berridge, PLC

20090068717 - In vivo incorporation of unnatural amino acids: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.... Agent: Quine Intellectual Property Law Group, P.C.

20090068718 - Amino acid derivatives of indolinone based protein kinase inhibitors: Amino acid derivatives of pyrrolyl-indolinones and their amide or ester derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.... Agent: Schwegman, Lundberg & Woessner, P.A.

20090068719 - Immunoassays, haptens, immunogens and antibodies for anti-hiv therapeutics: This invention provides compounds, methods, immunoassays, and kits relating to active, metabolically sensitive (“met-sensitive”) moieties of anti-HIV therapeutics, such as HIV protease inhibitors (PI) and HIV non-nucleoside reverse transcriptase inhibitors (NNRTI).... Agent: Morgan, Lewis & Bockius LLP (sf)

20090068720 - Useful polypeptides: The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyl transferase activity; a method for producing the polypeptide; a DNA which encodes the polypeptide; a recombinant vector into which the DNA is inserted; a transformant comprising the recombinant vector; a method for producing a sugar chain or complex carbohydrate, using... Agent: Fitzpatrick Cella Harper & Scinto

20090068721 - Process for the production of recombinant activated human protein c for the treatment of sepsis: The present invention relates to a recombinant method of production of activated Protein C. The invention relates to a method of construction, transformation, expression, purification and production of recombinant activated human protein C. DNA constructs comprising the control elements associated with the gene of interest has been disclosed. The nucleic... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090068722 - Bacteriocins and novel bacterial strains: Novel bacteriocins produced by novel bacterial strains are used for at least reducing the levels of colonization by at least one target bacteria in animals, especially poultry.... Agent: Usda, Ars, Ott

20090068723 - Isolated fungal promoters and gene transcription terminators and methods of protein and chemical production in a fungus: The present invention encompasses isolated gene regulatory elements and gene transcription terminators that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention also encompasses a method of utilizing a fungus for protein or chemical production. A transformed... Agent: Wells St. John P.s.

20090068724 - Isolation of nucleic acid: The present invention provides a method of isolating nucleic acid from a sample, said method comprising contacting said sample with a detergent and a solid support, whereby soluble nucleic acid in said sample is bound to the support, and separating said support with bound nucleic acid from the sample. Where... Agent: Invitrogen Corporation C/o Intellevate

20090068725 - Bioreactor for methanization of biomass having a high solids fraction: A bioreactor having improved gas yield is described, wherein the necessary residence time of the biomass in the digestion tank is reduced. During the fermentation of dry, i.e. non-pumpable biomass, percolating juices, so-called percolate, is generated as a result of the moisture contained in the biomass, which percolate is withdrawn... Agent: Morrison & Foerster, LLP

20090068726 - Optical device for blood analysis, analysis apparatus equipped with such a device: Optical device (200) for blood analysis is in particular designed for the counting and differentiation of leucocytes in an automatic blood analysis apparatus and includes a light source (201) of the electroluminescent diode type in order to illuminate a blood sample (311) circulating in an optical tank.... Agent: Young & Thompson

20090068727 - Closed system, shallow channel photobioreactor: The present subject matter provides examples of a photobioreactor for producing biomass material using a continuous flow of liquid growth media, the apparatus comprising a channel including a bottom portion, a first sidewall portion connected to the bottom portion, and a second sidewall portion connected to the bottom portion opposite... Agent: Schwegman, Lundberg & Woessner, P.A.

20090068728 - Cell incubator: A cell incubator having an observation unit to observe a cell incubation process comprises: a focus detecting unit to detect a focus position of an imaging optical system of the observation unit; an optimum focus selecting unit to select an optimum focus position based upon a plurality of images taken... Agent: Staas & Halsey LLP

20090068729 - Fluid containment for laboratory containers: A culture dish assembly includes a polygonal culture dish with a bottom wall and a side wall enclosure formed by a plurality of generally planar panels joined consecutively to one another by non-planar corners. The side wall enclosure includes a generally planar top edge. Inner surface regions of a plurality... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20090068730 - Friction fit contact plate: A contact plate for growing cell cultures, bacteria cultures, and the like, comprising a base and a cover. The base has a bottom wall for holding the culture medium and the like, and a circumferential sidewall extending upwardly from the bottom wall and attached thereto. The base further incorporates a... Agent: Dennison Associates

20090068731 - Novel process, construct and conjugate for producing multiple nucleic acid copies: This invention provides inter alia an in vitro process for producing multiple specific nucleic acid copies in which the copies are produced under isostatic conditions, by degradation of primer sequences from extended primers, thereby allowing subsequent priming events on the same template.... Agent: Cheryl H Agris Phd

20090068732 - Directed evolution methods for improving polypeptide folding and solubility and superfolder fluorescent proteins generated thereby: The current invention provides methods of improving folding of polypeptides using a poorly folding domain as a component of a fusion protein comprising the poorly folding domain and a polypeptide of interest to be improved. The invention also provides novel green fluorescent proteins (GFPs) and red fluorescent proteins that have... Agent: Los Alamos National Security, LLC

20090068733 - T2r, a novel family of taste receptors: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.... Agent: Townsend And Townsend And Crew, LLP

20090068734 - Human salivary gland-origin stem cell: A novel human stem cell which can be differentiated to cells constituting a plurality of human organs including human liver is disclosed. The human stem cell according to the present invention is originated from human salivary gland, which is CD49f-positive, and which can be differentiated to (1) a nestin-positive and... Agent: Birch Stewart Kolasch & Birch

20090068735 - Methods of isolating bipotent hepatic progenitor cells: A method of obtaining a mixture of cells enriched in hepatic progenitors is developed which comprises methods yielding suspensions of a mixture of cell types, and selecting those cells that are classical MHC class I antigen(s) negative and ICAM-1 antigen positive. The weak or dull expression of nonclassical MHC class... Agent: Foley And Lardner LLP Suite 500

20090068738 - Compositions and methods for modification of biomolecules: The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating... Agent: Bozicevic, Field & Francis LLP

20090068737 - Methods of inhibiting interleukin-17 receptor: Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.... Agent: Immunex Corporation Law Department

20090068736 - Mutant proline-and-arginine rich peptides and methods for using the same: The present invention relates to mutant proline-and-arginine rich (PR) peptides with defined structural characteristics for use in inhibiting mammalian 20S proteasome activity and modulating expression of genes regulating the NF-κB pathway. Mutant PR peptides of the present invention differ from wild-type PR peptides by having at least one to three... Agent: Licata & Tyrrell P.C.

20090068739 - Cell culture scaffold, methods of manufacturing the scaffold and cell culture methods: A cell culture scaffold containing a gel having a network structure comprised of a synthetic polymer such that cultured cells spread in a shorter time and the number of adsorbed cultured cells per unit area is larger than in the case of using a gel having a network structure comprised... Agent: The Nath Law Group

20090068740 - Amorphous cell delivery vehicle treated with physical/physicochemical stimuli: Provided are compositions and methods for in vitro generation and in vivo use of tissue for the repair of defective tissue, especially cartilage. Chondrocytes or other cells are cultured in vitro in a biodegradable amorphous carrier within the confines of a space bounded by a semi-permeable membrane with a molecular... Agent: Wolf Greenfield & Sacks, P.C.

20090068741 - Methods and compositions for improving the health of cells in culture: The invention relates generally to improving the growth properties of cells in culture and more specifically to accumulating beneficial mutations in the genome of cells growing in culture. Methods are disclosed for isolating cells with improved growth properties for a number of different adverse cell culture conditions which develop during... Agent: Invitrogen Corporation C/o Intellevate

20090068743 - Cationic alpha-amino acid-containing biodegradable polymer gene transfer compositions: The invention provides gene transfer compositions using as the gene carrier a biodegradable polymer that contains one or more cationic alpha amino acids, such as arginine or agmatine. The compositions form a tight soluble complex with a poly nucleic acid suitable for transfecting target cells to effect translation of the... Agent: Dla Piper LLP (us)

20090068742 - Nuclear reprogramming factor: There is provided a nuclear reprogramming factor for a somatic cell, which comprises a gene product of each of the following three kinds of genes: an Oct family gene, a Klf family gene, and a Myc family gene, as a means for inducing reprogramming of a differentiated cell to conveniently... Agent: Greenblum & Bernstein, P.L.C

20090068744 - Vitreous cell line: The present invention provides a vitreous cell line capable of expressing an exogenous immortalizing gene, and a production method thereof. Since the vitreous cell line of the present invention can produce a sufficient number of cells and has constant and continuous proliferative capacity, it can be advantageously utilized for the... Agent: Leydig Voit & Mayer, Ltd

20090068745 - Compositions and methods for performing reverse gene therapy: The invention relates to compositions and methods for reverse gene therapy, wherein a gene therapy vector encoding a gene product (e.g. a protein) which is usually only expressed in cells of an abnormal tissue is delivered to a cell of an animal afflicted with a disease or disorder to alleviate... Agent: Dann, Dorfman, Herrell & Skillman

  
03/05/2009 > patent applications in patent subcategories. listing by industry category

20090061410 - Multiloop engineered heart muscle tissue: The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation and/or replacement therapy. The invention further refers to multiring EHT constructs which comprise at least two force-generating engineered heart tissue rings fused with each other and... Agent: Marshall, Gerstein & Borun LLP

20090061411 - Analysis of sulfated polysaccharides: The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.... Agent: Lowrie, Lando & Anastasi, LLP

20090061418 - Disposable analytical microprocessor device: The present invention generally relates to the determination of an analyte concentration (quantitative determination) or whether an analyte threshold level has been passed (qualitative determination) in a biological sample through employment of a disposable analytical microprocessor device. The device can include a batch-specific, self-executable algorithm for the calculation of the... Agent: Sonnenschein Nath & Rosenthal LLP

20090061419 - Genomic markers of hepatitis b virus associated with hepatocellular carcinoma: The present invention provides methods of predicting a pre-disposition of HBV-infected individuals to develop hepatacellular carcinoma (HCC).... Agent: Townsend And Townsend And Crew, LLP

20090061417 - Influenza a virus detection method and kit therefore: The invention provides oligonucleotides for a simple, specific and/or sensitive test for the presence of Influenza A. In particular, the present invention provides a primer(s), probe(s) and/or test(s) for Influenza A Subtype H5N1. Kits comprising probe(s) and/or primer(s) useful in the test are also provided.... Agent: Dann, Dorfman, Herrell & Skillman

20090061413 - Isothermal screening of hiv-1 related nucleic acids: The presently described technology relates generally to the art of molecular diagnostics and more particularly to point-of-care diagnostic methods and materials. The diagnostic methods and materials of the presently described technology are suitable for a variety of uses including but not limited to the bedside or field diagnosis of infectious... Agent: Mcandrews Held & Malloy, Ltd

20090061414 - Method for quantification of recombinant viruses: Titration is an important and critical step in dosing recombinant virus for gene therapy. A relatively fast, convenient and sensitive method that allows for precise quantification of recombinant retrovirus is presented. The method is based on PCR amplification of a foreign gene by the PRINS (primer in situ DNA synthesis)... Agent: Reed Smith LLP

20090061412 - Methods for detecting papillomavirus dna in blood plasma and serum: This invention relates to the detection of extracellular papillomavirus DNA in blood plasma or serum from a human or animal. In particular, the invention relates to the detection, identification, evaluation, or monitoring of neoplastic, premalignant or malignant disease associated with a papillomavirus. The invention thereby provides methods for the identification... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090061420 - Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance: The present invention is directed to the field of nucleic acid diagnostics and the identification of base variation in target nucleic acid sequences. More particularly, the present invention relates to the use of such genotypic characterization of a target population of HIV and the subsequent association, i.e., correlation, of this... Agent: Philip S. Johnson Johnson & Johnson

20090061415 - Sequences diagnostic for shrimp pathogens: Primers have been isolated that are diagnostic for the detection of the taura syndrome virus (TSV). The primers are based on a new portion of the TSV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20090061416 - Surfaces and methods for biosensor cellular assays: Disclosed is an apparatus for measuring ligand-induced cell activity as defined herein, the apparatus including: an optical biosensor having a contact surface including a compatibilizer zone, an optional surface modifier zone, and a live cell zone. The disclosure also provides a method of making the apparatus and methods for measuring... Agent: Corning Incorporated

20090061426 - Binary signaling assay using a split-polymerase: The present invention provides methods, kits and compositions for the detection of an analyte. In the methods of the invention, a complex is formed between two or more analyte specific probes (ASP) and an analyte. The analyte specific probes each have a portion of a polymerase which interact to form... Agent: Agilent Techologies Inc

20090061451 - Biosensors and related methods: Provided herein are biosensors that comprise a biological signal source linked to a substrate by a peptide nucleic acid spacer and methods of use of the biosensor. In one embodiment, the biosensor is used to detect prostate-specific antigen.... Agent: Jesse A. Hirshman, Esq.

20090061421 - Crystal structure of cmy-10, a beta-lactamase causing antibiotic resistance with extended-substrate spectrum: The present invention related to a method for crystallizing a CMY-10 being a β-lactamase with extended-substrate spectrum, a crystal of CMY-10, and a crystal structure of CMY-10. With utilization of three-dimensional structure of CMY-10 protein provided by the present invention, it is possible to develop novel antibiotics or inhibitors that... Agent: Edwards Angell Palmer & Dodge LLP

20090061432 - Cspcna isoform modifications and uses thereof: Methods and compositions to detect the presence of csPCNA isoform by identifying one or more posttranslational modifications are disclosed. Methods to identify csPCNA isoform through posttranslational modifications including methylesterification levels are disclosed.... Agent: Barnes & Thornburg LLP

20090061438 - Detection of microsatellite instability and its use in diagnosis of tumors: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to... Agent: Michael Best & Friedrich LLP

20090061454 - Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells: The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for... Agent: Morse, Barnes-brown & Pendleton, P.C. Attn:IPManager

20090061443 - Diagnostic and therapeutic targets for leukemia: The present invention relates to methods of identifying candidate compounds for the treatment of leukemia and diagnostic methods based on histone methylation and HoxA5 promoter activity.... Agent: Myers Bigel Sibley & Sajovec

20090061422 - Diagnostic markers of breast cancer treatment and progression and methods of use thereof: To maximize both the life expectancy and quality of life of patients with operable breast cancer, it is important to predict adjuvant treatment outcome and likelihood of progression before treatment. The instant invention details the usage of a machine-learning based method to develop a cross-validated model to predict the outcome... Agent: William C. Fuess

20090061441 - Epigenetic silencing of cyclooxygenase-2 affects clinical outcome in gastric cancer: The present invention discloses methods of using the methylation status of the COX-2 gene promoter region as a biomarker for a gastric cancer patient to determine a prognosis and a treatment regimen, and to monitor the progress of a treatment regimen.... Agent: Hogan & Hartson L.L.P.

20090061445 - Flux balance analysis with molecular crowding: Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium; calculating metabolic flux reorganization in various environments and at various growth rates; and calculating the maximum metabolic rate and optimal metabolite concentrations and enzyme... Agent: Jesse A. Hirshman, Esq.

20090061427 - Gene encoding protein responsible for flocculation property of yeast and use thereof: The present invention relates to a gene encoding a protein responsible for flocculation property of yeast and use thereof in particular, a brewery yeast with appropriate flocculation property for producing desired alcoholic beverages, alcoholic beverages produced with said yeast, and a method for producing said beverages. More particularly, the present... Agent: Drinker Biddle & Reath (dc)

20090061447 - High speed parallel molecular nucleic acid sequencing: A method and device is disclosed for high speed, automated sequencing of nucleic acid molecules. A nucleic acid molecule to be sequenced is exposed to a polymerase in the presence of nucleotides which are to be incorporated into a complementary nucleic acid strand. The polymerase carries a donor fluorophore, and... Agent: Klarquist Sparkman, LLP

20090061440 - Method for amplifying plural nucleic acid sequences for discrimination: The invention provides a method with fewer distribution of the amount of amplification among plural tags when the plural tags are used for multiplex detection using the tag.... Agent: Scully Scott Murphy & Presser, PC

20090061448 - Method for identifying oculoskeletal dysplasia in dogs: Provided are methods for identifying dogs as likely to be genetically normal, carriers of, or affected with Oculo-skeletal dysplasia (OSD) by determining the presence or absence of a drd2 COL9A2 mutation and/or a drd1 COL9A3 mutation. Also provided is a method for selective breeding of dogs and kits useful for... Agent: Hodgson Russ LLP The Guaranty Building

20090061446 - Method for quickly identifying pathogenic bacteria responsible for infection: A system rapidly detects and identifies pathogenic bacteria responsible for infection (particularly septicemia), and selects an appropriate antimicrobial drug. A method according to the present invention for detecting and identifying pathogenic bacteria includes performing gene amplification such as real-time PCR, and analyzing the combination of the melting temperatures (Tm values)... Agent: Harness, Dickey & Pierce, P.L.C

20090061431 - Method of prognosing and diagnosing hereditary spastic paraplegia, mutant nucleic acid molecules and polypeptides: A method for diagnosing the presence of hereditary spastic paraplegia (HSP) or predicting the risk of developing HSP in a human subject, comprising detecting the presence or absence of a defect in a gene encoding a polypeptide comprising the sequence of FIG. 9 (SEQ ID NO: 19), in a nucleic... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20090061453 - Methods and compositions for detecting colon cancers: This application describes methods and compositions for detecting and treating HLTF-associated neoplasia. Differential methylation of the HLTF nucleotide sequences has been observed in HLTF-associated neoplasia such as colon neoplasia.... Agent: Ropes & Gray LLP

20090061435 - Methods and compositions for rapid amplification, capture and detection of nucleic acids and proteins: A method for detecting the presence of a nucleic acid template (110) in a sample includes the steps of combining the sample in a reaction vessel with a first primer (112F) and a second primer (112R) having a first section (114), a second section (118) and a spacer (116). The... Agent: James P. Broder Roeder & Broder LLP

20090061439 - Methods and compositions for sequencing a nucleic acid: The invention provides nucleotide analogs and methods of using them in sequencing reactions.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090061425 - Methods and kits for selectively amplifying, detecting or quantifying target dna with specific end sequences: Disclosed herein are methods and kits for selectively amplifying, detecting or quantifying a DNA fragment with a specific end sequence, especially generated following restriction enzyme digestion. This method can be used, for example, to detect a hypomethylated DNA fragment. This methods and kits are especially useful in detecting or quantifying... Agent: Seed Intellectual Property Law Group PLLC

20090061437 - Nucleotide analogs: The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20090061433 - Nucleotide primer set and nucleotide probe for detecting genotype of serum amyloid a1(saa1): Provided is a LAMP-amplification nucleotide primer set for detection of the genotype of single nucleotide polymorphisms C-13T, C2995T and T3010C of the SAA1 gene. Also provided is a nucleotide probe for detection of the amplification product amplified with the primer set according to the present invention. Further provided is a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090061436 - Peptide sequence that promotes tumor invasion: An isolated sequence SGSSEEKQNAVSSEET (OPNcPEP) SEQ ID NO: 8, and uses thereof. The peptide enhanced soft agar clone formation but did not support the growth of cells in plastic dishes, consistent with supporting anchorage-independence rather than growth. This sequence represented and is unique for a domain around the splice junction... Agent: Thompson Hine L.L.P. Intellectual Property Group

20090061423 - Pharmacogenomic markers for prognosis of solid tumors: The present invention provides methods, systems and equipment for prognosis or evaluation of treatment of solid tumors. Gene markers that are prognostic of solid tumors can be identified according to the present invention. Each gene marker has altered expression patterns in PBMCs of solid tumor patients following initiation of an... Agent: Wyeth Patent Law Group

20090061444 - Phytochrome-based fluorophores: Genetically-engineered fluorophore molecules with increased fluorescence are provided. These fluorophores are derived from the domains of phytochromes, and in particular bacterial phytochromes. Methods for generating these fluorophores and various applications of these fluorophores are also provided.... Agent: Warf/bhgl

20090061452 - Polymorphisms in the human genes for oct 1 and their use in diagnostic and therapeutic applications: The present invention relates to a polymorphic OCT1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or... Agent: Ropes & Gray LLP

20090061434 - Primer composition and a kit useful for the identification of phyllanthus: The present invention relates to an oligonucleotide primer set useful for the identification of Phyllanthus at species level, and more particularly, it relates to an oligonucleotide primer set useful for the identification of Phyllanthus species selected from the group of 4 specific primer sets and also the invention is directed... Agent: Seed Intellectual Property Law Group PLLC

20090061429 - Reactive surfaces, substrates and methods of producing and using same: Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an otherwise non-reactive surface for use in different applications including single molecule analyses.... Agent: Morgan, Lewis & Bockius LLP (sf)

20090061430 - Reactive surfaces, substrates and methods of producing and using same: Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an otherwise non-reactive surface for use in different applications including single molecule analyses.... Agent: Morgan, Lewis & Bockius LLP (sf)

20090061442 - Screening assay to identify non-atp-competitors targeting protein kinase a: Methods for screening compounds for their activity as a protein kinase A modulators are provided. The methods are based on fluorescence polarization of peptide probes to identify drug candidates that act by activating or inhibiting the catalytic function of PKA. In certain embodiments, the methods are adapted for high throughput... Agent: Jones Day

20090061450 - System and method for diagnosis of infectious diseases: A biosafe apparatus is disclosed for assay and diagnosis of respiratory pathogens comprising a nasal sampling device, a single entry, disposable microfluidic cartridge for target nucleic acid amplification, and an instrument with on-board assay control platform and target detection means.... Agent: Seed Intellectual Property Law Group PLLC

20090061449 - Systems and methods for processing hybrid seed: The present disclosure provides for systems and method for producing hybrid seed. In various embodiments, the disclosure provides a system for the high-throughput, nondestructive sampling of seeds. In another embodiment, a high-throughput, nondestructive method for producing hybrid seeds comprises removing a sample from a plurality of seeds in the population... Agent: Polster, Lieder, Woodruff & Lucchesi, L.c.

20090061428 - Thermal reaction device and method for using the same: An M times.N matrix microfluidic device for performing a matrix of reactions, the device having a plurality of reaction cells in communication with one of either a sample inlet or a reagent inlet through a via formed within an elastomeric block of the device. Methods provided include a method for... Agent: Townsend And Townsend And Crew, LLP

20090061424 - Universal ligation array for analyzing gene expression or genomic variations: The present invention provides an array system comprising a plurality of immobilized oligonucleotides comprising artificial sequences and a plurality of complementary ligation templates, as well as methods and kits for using the array system to analyze populations of nucleic acids. In particular, target nucleic acids are ligated to the immobilized... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20090061457 - Apolipoprotein e3 protein as a biomarker of parkinson's disease: The present invention relates to an Apolipoprotein E3 protein as a biomarker for neurodegenerative disease, including Parkinson's disease, and the related diseases. More specifically, the present invention relates to the identification of an Apolipoprotein E3 protein, useful for the screening, diagnosis, and differentiation of Parkinson's disease from Alzheimer's disease, other... Agent: Power3 Medical Products, Inc.

20090061458 - Heterooligomeric taste receptor: Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in sweet taste signaling as hetero-oligomeric complexes, and the genes and cDNA encoding the same, are... Agent: Hunton & Williams LLP Intellectual Property Department

20090061456 - Method for predicting progression free and overall survival at each follow-up time point during therapy of metastatic breast cancer patients using circulating tumor cells: A cancer test having prognostic utility in predicting time to disease progression, overall survival, and response to therapy in patients with MBC based upon the presence and number of CTC's. The Cell Spotter® System is used to enumerate CTC's in blood. The system immunomagnetically concentrates epithelial cells, fluorescently labels the... Agent: Philip S. Johnson Johnson & Johnson

20090061455 - Use of glycosaminoglycans to reduce non-specific binding in immunoassays: An immunoassay reagent is provided which comprises an analyte binding agent in a diluent, and a glycosaminoglycan in an amount sufficient to reduce non-specific binding in an assay of a sample for the analyte. Provided is such an immunoassay reagent in which the analyte is troponin I, the analyte binding... Agent: Philip S. Johnson Johnson & Johnson

20090061461 - Phosphorylated or non-phosphorylated mpr as diagnostic marker or therapeutic target: A method of diagnosing diseases associated with aberrant biological phenotypes including contacting a sample to be tested with at least one isoform of membrane associated progesterone receptor component 1 (mPR) as a diagnostic marker, and determining or estimating the degree of phosphorylation of the membrane associated progresterone receptor component 1... Agent: Ip Group Of Dla Piper US LLP

20090061462 - Prion-specific peptide reagents: Peptide reagents that interact preferentially with the PrPsc form of the prion protein are described. Methods of using the reagents or antibodies to the reagents for detection, diagnosis, purification, therapy and prophylaxis for prions and prion-associated diseases are also described.... Agent: Novartis Vaccines And Diagnostics Inc.

20090061463 - P-selectin associated with eosinophils as a marker for asthma and correlating with b-1 integrin activation: Methods are provided for the detection of P-selectin associated with eosinophils and for the use of P-selectin as a biological marker for asthma. In one embodiment, the present invention relates to methods for detecting P-selectin in a sample containing eosinophils and quantifying the total number of eosinophils. In another embodiment,... Agent: Whyte Hirschboeck Dudek S.c./warf Intellectual Property Department

20090061464 - Methods for detecting and/or quantifying a concentration of specific bacterial molecules using bacterial biosensors: A real-time method employing a portable peptide-containing potentiometric biosensor, can directly detect and/or quantify bacterial spores. Two peptides for specific recognition of B. subtilis and B. anthracis Sterne may be immobilized by a polysiloxane monolayer immobilization (PMI) technique. The sensors translate the biological recognition event into a potential change by... Agent: Straub & Pokotylo

20090061459 - Reagents for the detection of protein phosphorylation in carcinoma signaling pathways: The invention discloses nearly 443 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose.... Agent: Simona Levi-minzi, Ph.d. General Counsel

20090061460 - Test apparatus, production method therefor and test method: Test apparatus for detecting an analyte (A) contained in a sample liquid, comprising a dry porous carrier (10), on which a selective binder (12), capable of selectively binding the analyte (A) after the carrier (10) is wetted with the sample fluid, is arranged in a reaction zone (20), wherein furthermore... Agent: Patent Central LLC Stephan A. Pendorf

20090061466 - Anti-drug antibody assay: The invention provides a method for the immunological determination of an antibody against a drug antibody in a sample using a double antigen bridging immunoassay comprising a capture drug antibody and a tracer drug antibody, characterized in that the capture drug antibody is a mixture of said drug antibody conjugated... Agent: Hoffmann-la Roche Inc. Patent Law Department

20090061465 - Composition for analyzing diabetes mellitus and/or retinal vascular disease and analyzing method thereof: Disclosed are composition for diagnosing a diabetes mellitus and a retinal vascular disease, a kit for diagnosing the retinal vascular disease including the protein, a gene encoding the protein, and a method for analyzing an antibody prepared by the diabetes mellitus and/or the retinal vascular disease using the same.... Agent: Edwards Angell Palmer & Dodge LLP

20090061467 - Methods and compositions for measuring canine bnp and uses thereof: The present invention describes compositions and methods designed to determine the presence or amount of BNP or fragments thereof in a sample. In particular, the invention provides materials that may be configured to bind canine BNP in a sandwich assay format. The present invention provides, inter alia, assays designed to... Agent: Inverness Medical Innovations / Wsgr Wilson Sonsini Goodrich & Rosati, P.C.

20090061468 - Reagent and method for measuring coagulation time of blood sample: A method for measuring coagulation time is also described herein. The method comprises a contacting step and a measuring step. The contacting step is to contact a blood sample, calcium and compound selected from the group consisting of partial thromboplastin, tissue thromboplastin, and complex of tissue factor and phospholipid, in... Agent: Sughrue Mion, PLLC

20090061469 - Methods and kits for assaying acetyl transferase or deacetylase activity: The invention provides methods and kits for characterizing the activity of an acetyl transferase or deacetylase. The method involves enzymatically acetylating or deacetylating in vitro a substrate that is a peptide fragment of a full-length polypeptide, and then non-enzymatically acylating the peptide substrate with acyl groups that differ in molecular... Agent: Hugh Mctavish Mctavish Patent Firm

20090061470 - Use of human hepatocytes for determining liver function and liver regeneration: The use of human hepatocytes to determine the liver function and the liver regeneration in a test person, in particular a patient, as well as the use of these human hepatocytes as parameters for prognoses. Also, an in-vitro method to determine the liver function of a test person, in particular... Agent: Jordan And Hamburg LLP

20090061471 - Methods and systems for selective fluorination of organic molecules: A method and system for selectively fluorinating organic molecules on a target site wherein the target site is activated and then fluorinated are shown together with a method and system for identifying a molecule having a biological activity.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20090061472 - Assessing the risk of a major adverse cardiac event in patients with chest pain: Methods for characterizing the near term risk of experiencing a major adverse cardiac event in a patient presenting with chest pain are provided. In one embodiment the method comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtained from the patient. In another embodiment, the method comprises... Agent: Calfee Halter & Griswold, LLP

20090061474 - Cells and methods for estimation of effects on neurological dysfunction: The invention provides neuron-derived cells obtained by transfecting a receptor-expressing nucleic acid having an aryl hydrocarbon receptor gene, wherein outgrowth of neurites is not observed without adding a substance for the aryl hydrocarbon receptor, and outgrowth of neurites is observed by adding the substance for the aryl hydrocarbon receptor. The... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090061473 - Measurement of carbonaceous particles in biological samples: Disclosed is a method of quantitative estimation of carbonaceous particles in biological samples such as biological cells and tissues.... Agent: Summa, Additon & Ashe, P.A.

20090061475 - Methods for identifying compounds for the treatment of type 1 diabetes: The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic β cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090061478 - High-speed quantification of antigen specific t-cells in whole blood by flow cytometry: The present invention discloses novel methods and compositions for identifying particular cell types in whole blood samples and defining either the concentration or ‘absolute count’ of these cells per unit volume of the sample. More specifically, the invention relates to methods for quantifying the antigen-specific T cells or defining the... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090061476 - Method and apparatus for imaging target components in a biological sample using permanent magnets: A system for enumeration of cells in fluids by image cytometry is described for assessment of target populations such as leukocyte subsets in different bodily fluids or bacterial contamination in environmental samples, food products and bodily fluids. Briefly, all cells in a biological sample are fluorescently labeled, but only the... Agent: Philip S. Johnson Johnson & Johnson

20090061477 - Method and apparatus for imaging target components in a biological sample using permanent magnets: A system for enumeration of cells in fluids by image cytometry is described for assessment of target populations such as leukocyte subsets in different bodily fluids or bacterial contamination in environmental samples, food products and bodily fluids. Briefly, fluorescently labeled target cells are linked to magnetic particles or beads. In... Agent: Philip S. Johnson Johnson & Johnson

20090061479 - Mineralized three-dimensional bone constructs: The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture... Agent: Greenberg Traurig, LLP

20090061483 - Acid fungal proteases: The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and host cells including nucleic acid sequences coding for the proteases, methods for... Agent: Lynn Marcus-wyner Genecor International, Inc.

20090061484 - Enzymatic hydrolysis of lignocellulosic feedstocks using accessory enzymes: Provided is an enzyme mixture for hydrolyzing a pretreated lignocellulosic feedstock to soluble sugars. The enzyme mixture comprises EG4 at a fractional concentration (fEG4) of about 0.25 to about 0.83 (w/w), Swollenin at a fractional concentration (fSwo1) of about 0 to about 0.66 (w/w), and Cip1 at a fractional concentration... Agent: Fitzpatrick Cella Harper & Scinto

20090061481 - Highly-efficient hyperthermophilic dna ligase: Disclosed is a modified hyperthermophilic DNA ligase having improved DNA binding ability and reactivity. The modified hyperthermophilic DNA ligase has an amino acid sequence corresponding to the amino acid sequence of a heat-resistant DNA ligase derived from a thermophilic bacterium, a hyperthermophilic bacterium, a thermophilic archaebacterium, or a hyperthermophilic archaebacterium,... Agent: Mattingly, Stanger, Malur & Brundidge, P.C.

20090061480 - Nucleotide sequence encoding a modulator of nf-kb: The present invention relates to nucleotide sequences encoding a modulator of NF-κB, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-κB-activating stimuli, including HTLV-1 Tax, LPS, PMA... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090061482 - Nucleotide sequences of coryneform bacteria coded for proteins participating in l-serine metabolism and method for microbial production of l-serine: This invention relates to the nucleotide sequence of coryneform bacteria coding for proteins which are involved in L-serine metabolism with reduced and switched off L-serine dehydratase activity. The invention also relates to microorganisms used in methods for producing L-serine.... Agent: K.f. Ross P.C.

20090061485 - Method of producing an antibody using a cell in which the function of fucose transporter is inhibited: The present invention relates to a method of producing a recombinant protein, particularly an antibody, using a cell in which the function of a fucose transporter is inhibited, and it also provides a cell in which the expression of fucose transporter genes on both homologous chromosomes is artificially suppressed.... Agent: Birch Stewart Kolasch & Birch

20090061486 - Method for cellulase production: A fermentation process using hemicellulose-derived carbohydrates for the production of cellulase mixtures with a high proportion of cellulases relative to hemicellulases is provided. The cellulases produced by the process of the invention are further characterized by high specific productivity. The resulting cellulase mixtures comprise at least two times more cellulase... Agent: Fitzpatrick Cella Harper & Scinto

20090061487 - Sirna and methods of manufacture: Double-stranded RNA of about 19 to about 25 nucleotides in length capable of regulating gene expression by RNA interference is provided. Such double-stranded RNA are particularly useful for treating disease or conditions associated with a target mRNA or gene. Methods of manufacture and methods of use of the double-stranded RNA... Agent: Pepper Hamilton LLP

20090061488 - Method of synthesizing a target polynucleotide encoding a protein: The present invention provides a method of synthesizing a target polynucleotide encoding a protein, which uses a primer extension technique to constitute the target polynucleotide sequence. Preferably, the method is applied in a method for highly expressing a protein encoded by the target polynucleotide in a host.... Agent: Ladas & Parry LLP

20090061489 - Microfluidic devices with integrated resistive heater electrodes including systems and methods for controlling and measuring the temperatures of such heater electrodes: The invention relates to methods and devices for control of an integrated thin-film device with a plurality of microfluidic channels. In one embodiment, the microfluidic device includes a microfluidic chip comprising a first zone having a plurality of microfluidic channels and a second zone having a plurality of microfluidic channels,... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090061490 - Method for the production of a fermentation product from a pretreated lignocellulosic feedstock: A method for obtaining a fermentation product from a sugar hydrolysate obtained from a feedstock containing hemicellulose, by (i) removing suspended fiber solids from said sugar hydrolysate to obtain a clarified sugar solution; (ii) fermenting xylose in the clarified sugar solution in a fermentation reaction with yeast to produce a... Agent: Fitzpatrick Cella Harper & Scinto

20090061491 - Novel fermentation method: This invention relates to a process for recycling biomass in fermentation processes, whereby the biomass that accumulates in the production of fermentation products is prepared by means of a special process and is recycled into the system. The prepared biomass can be used again in the fermentative production of vitamins,... Agent: Nixon & Vanderhye, PC

20090061492 - Method for producing biodiesel: The present invention relates to the production of biodiesel. In particular, the present invention provides systems and methods for fermenting biomass materials with transgenic plant materials expressing the WRI1 transcription factor. In preferred embodiments, WRI1 is expressed in canola. The transgenic canola plants are fermented with a biomass source so... Agent: Peter G. Carroll Medlen & Carroll, LLP

20090061493 - Lipid pathway modification in oil-bearing microorganisms: The invention provides methods of modifying the lipids produced by microbial organisms through genetic engineering. The invention also provides genetically engineered microbes and methods of fermenting microbes for oil production. Also provided are oils, fuels, oleochemicals, chemical precursors, and other compounds manufactured by such modified microorganisms. Exemplary oil-bearing organisms include... Agent: Townsend And Townsend And Crew, LLP

20090061494 - Enzymatic conversion of epoxides to diols: Diols of the formula I: or corresponding polymers wherein R1 has been integrated into a polymeric backbone, wherein n ranges from (1) to (4); X is a divalent linking group selected from the group consisting of ether, ester, amino and amido groups; R1 is an n-valent hydrocarbon residue containing at... Agent: Joann Villamizar Ciba Corporation/patent Department

20090061495 - Treatment systems and processes for lignocellulosic substrates that contain soluble carbohydrates: A biorefining process used to convert lignocellulosic biomass into ethanol via a fermentation pathway. In a first pretreatment process step, the biomass is mixed with an aqueous wash solution to remove soluble carbohydrates from the biomass structure. Next, the solid fraction is separated from a liquid fraction. In a second... Agent: White-welker & Welker, LLC

20090061496 - Encapsulation of bacteria and viruses in electrospun fibers: A method of preserving organisms in viable form, the method comprising: suspending organisms in a solution of electrospinnable polymer; drawing droplets of said solution through a spinneret; applying an electrostatic field to said droplets under electrospinning conditions; so as to form fibers having a diameter no greater than about 5... Agent: Staas & Halsey LLP

20090061497 - Methods for extraction and purification of components of biological samples: A method is provided for extracting and purifying components of biological samples with a two-step process for elution and neutralization of the components from the sample. The separate elution and neutralization steps use adjustment of the buffer pH to improve extraction and purification of the desired components.... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20090061498 - Polyhydroxyalkanoate-containing structure and manufacturing method thereof: A method for manufacturing polyhydroxyalkanoate-containing structure, at least a part of a base material surface of the structure being coated with polyhydroxyalkanoate, the method comprises the steps of immobilizing a polyhydroxyalkanoate synthase on the base material surface, synthesizing, on the base material surface, polyhydroxyalkanoate using a 3-hydroxyacyl coenzyme A to... Agent: Fitzpatrick Cella Harper & Scinto

20090061499 - Method for industrial production of biocatalysts in the form of enzymes or microorganisms immobilized in polyvinyl alcohol gel, their use and devices for their production: A method for the industrial production of the biocatalysts with biologically active material in the form of immobilized enzymes or microorganisms which are immobilized into the polyvinyl alcohol gel, and their use based on the fact, that the active biological material, formed by the mixture of free native or pretreated... Agent: Oppedahl Patent Law Firm LLC

20090061500 - Novel protein-deamidating enzyme, microorganism producing the same, gene encoding the same, production process therefor, and use thereof: A method for the production of an enzyme, which comprises culturing in a medium a strain that belongs to a bacterium classified into Cytophagales or Actinomycetes, or a new bacterium Chryseobacterium sp. No. 9670 belonging to the genus Chryseobacterium, and has the ability to produce an enzyme having a property... Agent: Edwards Angell Palmer & Dodge LLP

20090061501 - Ethanol resistant and furfural resistant strains of e. coli fbr5 for production of ethanol from cellulosic biomass: Ethanol and furfural challenged strains of E. coli FBR5 exhibiting higher ethanol yield, productivity, and tolerance to both ethanol and furfural than FBR5 and methods for producing same.... Agent: John F. Letchford

20090061502 - Ethanol productivities of saccharomyces cerevisiae strains in fermentation of dilute-acid hydrolyzates depend on their furan reduction capacities: The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group furfural and 5-hydroxy-methyl furfural, in a batch, fed-batch or continuous fermentation, said microbial strain being tolerant to such... Agent: Gauthier & Connors, LLP

20090061503 - Heap leaching of sulphide ores: A process for the heap leaching of multiple ores, the process characterized by the process steps of: (i) the agglomeration or wetting of an ore feed; (ii) exposing the agglomerated or wetted ore to an inoculum containing one or more bacterial species capable of biooxidizing sulphide minerals in that ore;... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20090061504 - Apparatus for performing magnetic electroporation: An apparatus for performing magnetic electroporation is disclosed. A required electric field for electroporation is generated using a pulsed magnetic field through a closed magnetic yoke, such as a toroid, placed in a flow path of a fluid medium to be processed. The fluid medium flows through the orifice of... Agent: Dillon & Yudell LLP

20090061505 - Apparatus for selective excitation of microparticles: Nucleic acid microparticles are sequenced by performing a sequencing reaction on the microparticles using one or more selectively exciting the microparticles in an excitation pattern, optically imaging the microparticles at a resolution insufficient to resolve individual microparticles, and processing the optical images of the microparticles using information on the excitation... Agent: Fenwick & West LLP

20090061506 - Method for precipitating mono and multiple layers of organophosphoric and organophosphonic acids and the salts thereof in addition to use thereof: c

20090061507 - Fluorescence-based lateral flow device with improved sensitivity: The invention describes how to use nanometer scale fluorescence particles as a label material for fluorescence lateral flow device application. The utilization of the nanoparticles instantly increases the fluorescence intensity by thousands to millions of times. The resulting signal enhancement not only significantly increase sensitivity for analyte detection, but also... Agent: Winston Z. Ho

20090061508 - Laminar flow reactor: A Laminar Flow reactor for large scale culturing or packaging of cell suspensions, three-dimensional tissue and other biological systems is disclosed. The Laminar Flow reactor consists of an upper housing and a lower housing. The housings are interconnected by a plurality of connectors and a plurality of rigid spacers, an... Agent: Herbert P. Von Schroeder

20090061509 - Treatment system of high concentration organic sewage: The present invention relates to a treatment system of high concentration organic sewage treatment. The system mainly comprises a chemical settling device, an anoxic biochemical treatment fluidized bed, an anaerobic biochemical treatment fluidized bed and an aerobic biochemical treatment fluidized bed. The said primary filter device, chemical settling device, anoxic... Agent: Ying Chen Chen Yoshimura LLP

20090061510 - Anti-angiogenic polypeptides: Anti-angiogenic polypeptides A61 or p22 are disclosed. Also disclosed are methods of making the polypeptides and methods of treating subjects having angiogenic diseases or conditions.... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20090061511 - Gamma-1 and gamma-3 anti-human cd23 monoclonal antibodies and use thereof as therapeutics: Monoclonal antibodies which specifically bind human CD23, the low affinity receptor for IgE (FceRII/CD23), and contain either a human gamma-1 or human gamma-3 constant domain, are disclosed. The antibodies are useful for modulating or inhibiting induced IgE expression. Accordingly, they have practical utility in the treatment or prophylaxis of disease... Agent: Pillsbury Winthrop Shaw Pittman LLP

20090061513 - Cell sorting and cell cultivation methods: n

20090061512 - Culture medium for gingival fibroblasts:

20090061515 - Methods of inhibiting or suppressing cellular proliferation: Methods of inhibiting or suppressing cellular proliferation are disclosed that include delivering at least one antiproliferative agent into or proximate a cell. In certain embodiments, the antiproliferative agent(s) are hydrolysis products of a biodegradable polymer (e.g., a polyketal polymer).... Agent: Mueting, Raasch & Gebhardt, P.A.

20090061514 - Use of cytokines and mitogens to inhibit graft versus host disease: A method for inducing T cell tolerance in peripheral blood mononuclear cells (PBMCs) comprising adding a suppressive composition to said cells.... Agent: Morgan, Lewis & Bockius, LLP

20090061516 - Animal cell culture media comprising non animal or plant derived nutrients: The present invention provides serum-free cell culture media formulations which are capable of supporting the in vitro cultivation of animal cells. The media comprise at least one nutrient of non-animal derivation, such as at least one plant peptide and/or at least one non-animal or plant lipid and/or fatty acid. The... Agent: Invitrogen Corporation C/o Intellevate

20090061517 - Cell culture apparatus and methods of making and using same: The present invention provides compositions and articles for cell culture and methods for preparing the compositions and articles. Generally, the article can include a porous biocompatible polymer scaffold. The scaffold may be prepared by preparing a polymer composition that includes a biocompatible polymer and a porogen, then removing the porogen.... Agent: Mueting, Raasch & Gebhardt, P.A.

20090061518 - System and method for dispensing dehydrated culture media powder: An improved system and method for dispensing dehydrated culture media (DCM) powder into containers for preparation as a culture media. The manual and automated systems and methods operate to dispense DCM powder, as well as liquid, into vessels or media preparation instruments in a manner to avoid DCM dust inhalation... Agent: Drinker Biddle & Reath (dc)

20090061519 - Metabolic regulators: The present invention provides methods to make soluble or membrane-anchored metabolic regulators for use in prokaryotes or eukaryotes. The present invention provides methods of expressing novel protein constructs that bind to specific metabolites to control their availability in the cell. The invention utilizes bacterial periplasmic binding proteins, or domains from... Agent: Banner & Witcoff, Ltd.

20090061520 - Synthetic biology vectors: The present invention provides compositions, methods and kits for generating synthetic genetic circuits in biological systems. In particular, the present invention provides vectors, reagents and methods of their use in constructing synthetic genetic circuits in bacteria.... Agent: Casimir Jones, S.c.

20090061521 - Recombinant negative strand rna virus expression systems and vaccines: The present invention relates methods of generating infectious negative-strand virus in host cells by an entirely vector-based system without the aid of a helper virus. In particular, the present invention relates methods of generating infectious recombinant negative-strand RNA viruses intracellularly in the absence of helper virus from expression vectors comprising... Agent: Pennie & Edmonds LLP

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