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Chemistry: molecular biology and microbiology February patent applications/inventions, industry category 02/09Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 02/26/2009 > patent applications in patent subcategories. patent applications/inventions, industry category
20090053686 - Particle switching systems and methods using acoustic radiation pressure: The present invention comprises methods and systems that use acoustic radiation pressure.... Agent: Peacock Myers, P.C.
20090053688 - method and device for ultrasound assisted particle agglutination assay: Ultrasound-assisted particle agglutination assay methods and apparatuses are described based on first providing a standing wave ultrasound field at a resonance frequency of a test liquid in a resonator cell containing microparticles covered with a binding agent with high affinity to an analyte sought to be detected by the assay... Agent: Boris Leschinsky
20090053691 - Cell line and methods for determining viral titer: The present invention relates to cells, methods, compositions and kits for determining the concentration of virus in a stock, i.e., determining the titer of a viral stock.... Agent: Invitrogen Corporation C/o Intellevate
20090053692 - Detection of hiv-1 by nucleic acid amplification: Nucleic acid sequences and methods for detecting HIV-1 nucleic acid (LTR and pol sequences) in biological samples by detecting amplified nucleic acids are disclosed. Kits comprising nucleic acid oligomers for amplifying HIV-1 nucleic acid present in a biological sample and detecting the amplified nucleic acid are disclosed.... Agent: Gen Probe Incorporated
20090053689 - Device for processing a biological and/or chemical sample and method of using the same: The present invention relates to a device and an apparatus device for processing a biological and/or chemical sample. The device comprises at least one sample processing chamber having an inlet at a first end and a penetrable sealing layer at a second end that forms at least a part of... Agent: Biotechnology Law Group C/o Portfolioip
20090053687 - Method for the detection of hpv and probes, primers and kits: The invention relates to materials and methods method for detection and/or typing of any HPV nucleic acid possibly present in a biological sample, the method comprising the steps of: (i) amplification of a polynucleic acid fragment comprising or consisting of the B region of any HPV nucleic acid in the... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220
20090053690 - Surface chemistry and deposition techniques: Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface attachment features that are spaced apart on the surface such that when the analytes are labeled adjacent analytes are optically resolvable from each other. One... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090053719 - Analysis of nucleic acids by digital pcr: The present invention provides a method for analyzing nucleic acids for their lengths and relative abundance in a sample, based on digital amplification of individual template molecules. This invention has many applications, including those in noninvasive prenatal diagnosis, transplantation monitoring, and the detection and monitoring of cancers and virus-associated diseases.... Agent: Townsend And Townsend And Crew, LLP
20090053728 - Analytical method and kit: Analytical methods using RNA probes for the detection or analysis of nucleic acid sequences is described. These probes are contacted with a sample suspected of containing the nucleic acid sequence and if they form duplexes, they are hydrolysed. This may be done, for example during an amplification reaction. AMP generated... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP
20090053696 - Biomarker for heart failure: The present invention relates, in general, to heart failure, and, in particular, to a method of evaluating heart failure patients by monitoring β-adrenergic receptor kinase (βARK1) levels in lymphocytes from such patients.... Agent: Nixon & Vanderhye, PC
20090053701 - Detectable nucleic acid tag: Provided herein are nucleic acid tags that are linked to, or capable of linking to, a protein of interest. In particular, the nucleic acid tags are oligonucleotides comprising a reporter function and a protein tagging function. Also provided herein, are nucleic acid tag compositions, kits and methods of use thereof.... Agent: Jones Day
20090053706 - Dna methylation markers associated with the cpg island methylator phenotype (cimp) in human colorectal cancer: Particular aspects confirm the existence of a CpG island methylator phenotype (CIMP) in colorectal cancer, and provide novel validated DNA methylation markers associated with CIMP. Additional aspects provide novel methods and compositions for: determining CIMP status in colorectal cancers, determining the relationship between CIMP status and other molecular features of... Agent: Davis Wright Tremaine, LLP/seattle
20090053709 - Enhanced sensitivity of a cantilever sensor via specific bindings: Detection of miniscule amounts of an analyte is accomplished via multiple bindings of specific materials on a sensor configured to sense mass. The sensor is prepared by immobilizing an antibody to a surface of the sensor, wherein the antibody is known to bind to the analyte. The prepared sensor is... Agent: Woodcock Washburn LLP
20090053710 - Functional molecule, functional molecule synthesizing amidite and target substance analysis method: To provide a functional molecule including a modified nucleotide unit having a substituent introduced to a base thereof, wherein the substituent is removably introduced to the base; a functional molecule synthesizing amidite that has a substituent removably introduced to its base and that is used for the manufacture of the... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20090053695 - Gene marker and use thereof: Immune-related genes whose expression levels were increased by 1.5-fold or more because of rejection and whose expression levels were decreased by 1.5-fold or more because of immunosuppressive agents have been identified as gene markers. By using the expression level of one of these gene markers as an indicator, it becomes... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090053714 - Gins gene expression as marker for actively cycling cells and cell cycle phase: The invention relates to a method of detecting an actively cycling cell in a sample, said method comprising determining the state of GINS gene expression within said cell, wherein detection of GINS gene expression in said cell indicates that said cell is actively cycling. Furthermore, the invention relates to methods... Agent: Kathleen Williams Edwards Angell Palmer & Dodge LLP
20090053693 - Identification of polymorphisms in the epcr gene associated with thrombotic risk: The invention relates to an in vitro method for determining the risk of developing thrombosis in a subject, which method involves identifying a particular haplotype EPCR gene.... Agent: Stites & Harbison PLLC
20090053713 - Isolated nucleic acids and polypeptides associated with glucose homeostasis disorders and method of detecting the same: An isolated and substantially pure nucleic acid sequence located between D20S119 and D20S178 on human chromosome 20q13, the nucleic acid sequence including: a nucleic acid sequence coding for a glucose transporting protein and having the sequence shown in SEQ ID NO: 1; or a nucleic acid sequence having at least... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20090053708 - Method and/or apparatus of oligonucleotide design and/or nucleic acid detection: It is provided a method of designing at least one oligonucleotide for nucleic acid detection comprising the following steps in any order: (I) identifying and/or selecting region(s) of at least one target nucleic acid to be amplified, the region(s) having an efficiency of amplification (AE) higher than the average AE;... Agent: Dickstein Shapiro LLP
20090053729 - Method for detection of mutant gene: Disclosed is a method for detecting mutation(s) in nucleotide sequence, which comprises performing a nucleic acid amplification reaction by using an oligonucleotide or a salt thereof as a primer and a nucleic acid in a sample as a template and detecting a reaction product, wherein the oligonucleotide is so modified... Agent: Leydig Voit & Mayer, Ltd
20090053698 - Method for obtaining subtraction polynucleotide: s
20090053699 - Method for preparing polynucleotides for analysis: A method for analysing a target polynucleotide having distinct units of nucleic acid sequence comprising: (i) forming a first polynucleotide which is a concatemer having multiple repeating target polynucleotide sequences; (ii) forming on the first polynucleotide a second polynucleotide hybridised to a portion of one or more of the target... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090053716 - Method of detecting human cytochrome p450 (cyp) 2d6 gene mutation: A defect or multi-existence of a CYP2D6 gene is detected with a primer includes a complementary sequence to a sequence which is common between the CYP2D6 gene and a CYP2D8 gene but different from a CYP2D7 gene and which contains one or more of bases at the 86-, 90- and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090053717 - Methods and compositions for detecting spermatozoa or semen in a sample: The present invention concerns compositions and methods for evaluating fertility in humans and animals. The invention may also be used to identify reproductive cancers such as testicular cancer. In various embodiments of the invention, an Sptrx-3 enzyme is used as a fertility marker. Sptrx-3 may be detected in accordance with... Agent: Sonnenschein Nath & Rosenthal LLP
20090053705 - Methods for increasing accuracy of nucleic acid sequencing: The invention provides methods for improving the accuracy of a sequencing-by-synthesis reaction by sequencing at least a portion of a template and at least a portion of template complementary sequence.... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090053707 - Methods for lightening skin and hair: Methods are described wherein the skin of a vertebrate, or the skin or hair of a mammal can be lightened by administration of an agent, e.g., protein, peptide, active fusion protein, active fragment, or molecular mimic, that binds to BMP-4 transmembrane receptors on melanocytes and decreases the level of melanin... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20090053715 - Methods of screening nucleic acids for single nucleotide variations: Disclosed are methods and compositions for detecting variation in nucleic acids. The disclosed method compares the sequence of a nucleic acid of interest with the sequence of a reference nucleic acid to sensitively identify variations between the sequence of a nucleic acid of interest and the sequence of a reference... Agent: Ballard Spahr Andrews & Ingersoll, LLP
20090053712 - Methods of using ledgf/p75: The invention provides methods for diagnosing tumors in mammals using a reagent that bind to LEDGF/p75 or to a nucleic acid encoding LEDGF/p75. For example, the tumor may be located in the CNS, the prostate, the skin, the bone marrow, or the gut of the mammal. Also provided are methods... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20090053718 - Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mrnas: The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNAs and their target mRNAs, as well as small interfering RNAs (siRNAs). The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single... Agent: Clark & Elbing LLP
20090053700 - Optical sorting method: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which... Agent: Edwards Angell Palmer & Dodge LLP
20090053723 - Peripherin and neurofilament light protein splice variants in amyotrophic lateral sclerosis (als): Nucleotide sequences encoding novel splice variants of peripherin and neurofilament light protein, proteins encoded by the novel splice variants and antibodies thereto are disclosed. In addition, methods are described for detecting ALS in a subject suspected of having ALS, comprising detecting the presence or absence of the novel splice variants... Agent: Bereskin And Parr
20090053697 - Pharmacological applications of mitochondrial dna assays: The invention provides assays to determine the relative amount of mitochondrial DNA in a subject, such as a subject undergoing drug treatment. The subject may for example be a human patient undergoing treatment for an HIV infection with a nucleic acid precursor such as a nucleoside or nucleotide analogue. The... Agent: Jeffrey J. King, Esq. Black Lowe & Graham PLLC
20090053694 - Photochemically amplified bioassay: In the present invention, a reagent capable of immunospecific reaction with the analyte of interest is conjugated to a photocatalytic microparticle. After the immunospecific binding has occurred, the assay amplification is performed by exposing photocatalytic particles to actinic UV light in presence of an oxidizable compound. Photocatalytic particles are catalyzing... Agent: Pastel Law Firm Christopher R. Pastel
20090053711 - Pseudo-tissue for accuracy control, method for controlling accuracy by using the same, and method for manufacturing the same: The present invention provides a pseudo-tissue for accuracy control comprising a nucleic acid or cells, a holding body for holding the nucleic acid or cells, and a protecting body for covering at least a part of the surface of the holding body so as to protect the holding body. A... Agent: Sughrue Mion, PLLC
20090053727 - Risk assessment for adverse drug reactions: The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most... Agent: Occhiuti Rohlicek & Tsao, LLP
20090053722 - Sdad assay and uses thereof: Methods for screening human sperm using a sperm DNA accelerated decondensation (SDAD) Test, readable at a 5 minute time point, are disclosed. The method is useful in the screening and clinical management for a reproductively challenged human couple. The methods disclosed are highly predictive of ICSI outcome. Methods for screening... Agent: Bell, Boyd & Lloyd, LLP
20090053702 - Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories: The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the common bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection... Agent: Knobbe Martens Olson & Bear LLP
20090053703 - Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories: The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the common bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection... Agent: Knobbe Martens Olson & Bear LLP
20090053704 - Stabilization of nucleic acids on solid supports: The present invention provides methods, compositions, and kits for the storage and stabilization of biological molecules. The methods comprise applying Tris(2-carboxyethyl)phosphine (TCEP) to at least one biological molecule bound to a solid substrate and storing in an organic solvent. Preferably, the biological molecules are nucleic acids. Compositions and kits for... Agent: Agilent Techologies Inc
20090053720 - Suppression of amplification using an oligonucleotide and a polymerase significantly lacking 5'-3' nuclease activity: Methods and compositions for amplification of a target sequence by suppressing amplification of related sequences are provided.... Agent: Townsend And Townsend And Crew, LLP
20090053724 - System and method for adaptive reagent control in nucleic acid sequencing: An embodiment of a method for adaptive reagent control is described that comprising a) introducing a first concentration of an enzyme reagent into a reaction environment with a reaction substrate, where the enzyme reagent and reaction substrate are constituent parts of a sequencing process; b) measuring a level of activity... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20090053726 - Systems and methods for real-time pcr: In one aspect, the present invention provides a systems and methods for the real-time amplification and analysis of a sample of DNA.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090053725 - Using dna aptamers and quantum dots for the detection of proteins or other targets: The solutions provided here use DNA aptamers and quantum dots for the detection of bacteria, viruses, proteins or other targets. An example of a method described here comprises: providing a complex of DNA complementary strands, one strand being an aptamer, having one strand covalently linked to a quantum dot, and... Agent: Department Of The Air Force
20090053721 - Voltage-gated ion channel mutants for use in identifying ion channel modulating compounds: The present invention provides novel methods and compositions for identifying ion channel modulating compounds, including atrial-selective antiarrhythmic agents and ion channel modulating compounds that preferentially modulate K+ channels. The ion channel modulating compounds identified according to these methods are associated with a reduced incidence of ventricular proarrhythmia.... Agent: Seed Intellectual Property Law Group PLLC
20090053730 - Chimeric human t1r1 taste receptor polypeptides and compositions containing same: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department
20090053734 - Determination of am-binding proteins and the association of adrenomedullin (am) therewith: The present invention provides methods for the isolation, identification, and purification of adrenomedullin (AM)-binding proteins. Also, provided are methods for utilizing the purified AM-binding proteins, or functional portions thereof, to diagnose, treat, and monitor AM-related diseases, for example, diseases or disorders associated with abnormally elevated AM levels. In addition, the... Agent: Klarquist Sparkman, LLP
20090053731 - Method for detection of l523s expression in biological samples: The present invention discloses methods for differentiating between normal or reactive cells and malignant cells in biological samples comprising: exposing the biological sample to an antibody to L523S protein and detecting the presence of the antibody bound to L523S protein within the malignant cells, in embodiments, such methods may further... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090053732 - Microfluidic devices, methods and systems for detecting target molecules: Microfluidic devices methods and systems for detecting a target in a fluidic component of a sample are shown. In such devices, methods and systems, the flow resistance of various channels where the sample is introduced is adjusted to control separation of the fluidic component from the sample and/or performance of... Agent: Steinfl & Bruno
20090053733 - Simultaneous assay for determining drugs: c
20090053736 - Homogeneous chemiluminescent immunoassay for analysis of iron metalloproteins: The present invention relates to assays and kits for detecting or quantifying iron metalloprotein in test samples.... Agent: Robert Deberardine D-377/ap6a-1
20090053737 - Monoclonal antibody which binds met in formalin-fixed and paraffin-embedded tissues and related methods: In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4.... Agent: Price Heneveld Cooper Dewitt & Litton, LLP
20090053738 - Protease detection: A method of detecting a protease in a sample. The method comprises providing an analyte degradable by the protease. The analyte is contacted with the sample. The degradation products of the analyte or the residual undegraded analyte is detected in a binding assay.... Agent: Clark & Elbing LLP
20090053735 - Vector expressing n-deacetylase/n-sulfotransferase 2: An object of the present invention is to provide an expression vector that allows for stable production of N-deacetylase/N-sulfotransferase 2 in large amounts and a process for production of N-deacetylase/N-sulfotransferase 2 using the same. The present invention provides a recombinant baculovirus expression vector obtained by incorporating into baculovirus DNA, a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090053739 - Ligand for g-protein coupled receptor fprl2 and uses thereof: The present invention relates to methods, reagents and kits for detecting of formyl peptide receptor like-2 (FPRL2) polypeptide activity in a sample and identifying agents which modulate polypeptide activity. It further relates to antibodies raised against FPRL2. It further relates to substances for preventing, treating and/or alleviating diseases or disorders... Agent: Edwards Angell Palmer & Dodge LLP
20090053740 - Agglutination-based method for fast detection, isolation and quantification of apoptotic cells: The present invention relates to methods and kits for the detection, isolation and quantification of apoptotic cells based on the apoptotic cells' increased expression of alpha-D-mannose and/or beta-D-galactose containing glycoproteins. Lectins that bind to alpha-D-mannose and beta-D-galactose-rich glycoconjugates are used in the methods and kits for agglutination tests for the... Agent: Davis Wright Tremaine LLP/los Angeles
20090053742 - Capture and release based isotope tagged peptides and methods for using the same: The invention provides non-affinity based isotope tagged peptides, chemistries for making these peptides, and methods for using these peptides. In one aspect, tags comprise a reactive site (RS) for reacting with a molecule on a protein to form a stable association with the peptide (e.g., a covalent bond) and an... Agent: Edwards Angell Palmer & Dodge LLP
20090053743 - Anti-antibody reagent: An anti-antibody reagent for use in a competitive or sandwich simplex or multiplex assay, said reagent comprising one or more labeled anti-antibodies for the primary antibodies to be determined in the assay, the reagent further comprising a corresponding unlabeled anti-antibody in an excess or near excess concentration with respect to... Agent: Townsend And Townsend And Crew, LLP
20090053744 - Luciferase detection assay system: The invention relates to methods and kits for detecting enzyme activity using bioluminescence. In particular, it relates to a novel assay system with increased light yield for a sensitive and convenient detection of luciferase activity, such as luciferase reporter enzyme activity. Provided is a method of detecting luciferase activity in... Agent: Hoffmann & Baron, LLP
20090053745 - Methods and kits for regulation of microtubule assembly and dendrite growth and branching: Fragments of snapin important for interaction with cypin and thus regulating microtubule assembly are provided. Also provided are methods of use of said fragments and kits to facilitate said methods.... Agent: Fox Rothschild LLP Princeton Pike Corporate Center
20090053746 - Fret protease assays for botulinum serotype a/e toxins: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum... Agent: Dean G. Stathakis, Ph.d. Allergan, Inc. (t2-7h)
20090053747 - Measurement of haloperoxidase activity with chemiluminescent detection: The present invention relates to assays and kits for detecting haloperoxidase activity in test samples.... Agent: Robert Deberardine D-377/ap6a-1
20090053754 - Assay for low molecular weight heparin: A prothrombin time reagent for determination of low molecular weight heparin in fresh whole blood and in anti-coagulant treated blood is provided. The reagent is composed of recombinant animal tissue factor, and a mixture of synthetic phospholipids, which mixture includes a phosphatidylalcohol. A formulation buffer which includes a sensitivity adjuster... Agent: Fox Rothschild LLP
20090053751 - Chemiluminescent method and device for evaluating the in vivo functional state of phagocytes: A method of assessing the in vivo state of phagocytes in a patient, possibly indicating diagnostically important states such as inflammation or infection, which method utilizes chemiluminescent (CL) light emitted during the reaction in vitro between a CL substrate and the reactive oxygen species (ROS) formed in a fluid sample... Agent: Kevin D. Mccarthy Roach Brown Mccarthy & Gruber, P.C.
20090053748 - Cytochrome c protein and assay: The present invention relates to a a cytochrome c-reporter fusion protein construct comprising a modified cytochrome c protein which targets the mitochondria and has a reduced ability to induce apoptosis in a living cell. The invention also relates to nucleic acid constructs encoding such protein fusions and cells stably transfected... Agent: Ge Healthcare Bio-sciences Corp. Patent Department
20090053753 - Functional identification of proteins underlying icrac activity in a cell: The invention provides methods and compositions for determining the identity of CRACM homologs underlying Icrac activity in cells.... Agent: Morgan, Lewis & Bockius, LLP
20090053749 - Method and apparatus for high throughput diagnosis of diseased cells with microchannel devices: The method and apparatus of the present invention detects changes in cell biomechanics caused by any of a variety of diseases and conditions. In one embodiment, the method and apparatus of the invention detect infection of red blood cells. In one embodiment, the invention is a method and apparatus comprising... Agent: Choate, Hall & Stewart LLP
20090053756 - Method for monitoring and promoting the nutrition and well-being as well as the productivity of animals: The invention concerns a method for determining a characteristic describing the intestinal microbiota for an animal and/or a human being, in which method an animal and/or a human being is fed with a fodder/food; the number of two or more microorganisms in the intestine is determined; and the characteristic describing... Agent: Studebaker & Brackett PC
20090053750 - Methods and compositions for identifying a cellular immune response against prostate cancer: The present invention relates to filamin-B peptides, compositions comprising such peptides, and methods of using such peptides to assess an immune response against such peptides. An immune response against the peptides correlates with an immune response, in particular a cellular immune response, against prostate cancer cells which immune response is... Agent: Jones Day
20090053755 - Probe based molecular signal delivery for precise control and measurement of single cell responses: A system for producing and visualizing the response of a cell. The cell has a surface. A probe is provided. The probe is derivitized so that at least one bio-active molecule is covalently linked to the probe. The probe with the at least one bio-active molecule covalently linked to the... Agent: Lawrence Livermore National Security, LLC
20090053757 - Screening method for selecting plants that show a reduced wound-induced surface discolouration: Provided is a method for screening a population of plants or plant parts for the presence of individuals showing reduced discolouration compared to a control plant or plant part. The method comprises providing a population of plants or plant parts, optionally creating a wound surface, and incubating the plant, plant... Agent: Frommer Lawrence & Haug
20090053752 - Use of an in vitro hemodynamic endothelial/smooth muscle cell co-culture model to identify new therapeutic targets for vascular disease: An in vitro biomechanical model used to applied hemodynamic (i.e., blood flow) patterns modeled after the human circulation to human/animal cells in culture. This model replicates hemodynamic flow patterns that are measured directly from the human circulation using non-invasive magnetic resonance imaging and translated to the motor that controls the... Agent: Hogan & Hartson LLPIPGroup, Columbia Square
20090053758 - Processes for clonal growth of hepatic progenitor cells:
20090053759 - Method and device for preparing biological samples: A method for preparing biological samples by means of a series of different liquids containing preparation agents in a chamber is provided. The chamber comprises a first and a second opening for supplying and removing liquid to and from the chamber. The chamber is brought into a first position, in... Agent: Workman Nydegger 1000 Eagle Gate Tower
20090053762 - Cell/tissue culturing device, system and method: A device, system and method for axenically culturing and harvesting cells and/or tissues, including bioreactors and fermentors. The device is preferably disposable but nevertheless may be used continuously for a plurality of consecutive culturing/harvesting cycles prior to disposal of same. This invention also relates to batteries of such devices which... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20090053766 - Methods and compositions for producing recombinant proteins using a gene for trna: The invention relates to host cells with improved protein expressed properties. The host cells comprise rare tRNA genes within the one or more rRNA operons.... Agent: Howrey LLP - Dc
20090053761 - Polypeptide mutagenesis method: There is provided a method for altering the amino acid sequence of a target polypeptide by altering a target DNA sequence which encodes that polypeptide, the method comprising the step of introducing a transposon into the target DNA sequence, in which the transposon comprises a first restriction enzyme recognition sequence... Agent: Morrison & Foerster LLP
20090053764 - Salutaridinol 7-0-acetyltransferase and derivatives thereof: This invention provides a protein comprising consecutive amino acids, the amino acid sequence of which is illustrated in FIG. 8 (SEQ. ID No. 14) or, a fragment thereof having at least 15 amino acids, or a variant thereof, the sequence of which has at least 70% identity with the amino... Agent: Thompson Coburn, LLP
20090053763 - Tumor endothelial marker 7-alpha molecules and uses thereof: The present invention provides Tumor Endothelial Marker 7α (TEM7α) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TEM7α polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases,... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090053765 - Variants of beta-glucosidase: The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1... Agent: Novozymes, Inc.
20090053767 - Method for producing human insulin-like growth factor i: e
20090053768 - Novel phospholipase c enzyme (s): The present invention provides a phospholipase C enzyme(s) having ability to hydrolyze phospholipid in both acidic and around neutral ranges and the activity in a citrate buffer solution as well as having some degree of heat stability, and having a property not to hydrolyze phosphate esters not containing lipid moieties.... Agent: Frishauf, Holtz, Goodman & Chick, PC
20090053769 - Heterologous production of natural products in bacteria: The present invention demonstrates an example of the de novo total biosynthesis of biologically active forms of heterologous NRPs in Escherichia coli (E. coli). The system can serve not only as an effective and flexible platform for large-scale preparation of natural products from simple carbon and nitrogen sources, but also... Agent: Hogan & Hartson L.L.P.
20090053770 - Biomass pretreatment: A method is provided for producing an improved pretreated biomass product for use in saccharification followed by fermentation to produce a target chemical that includes removal of saccharification and or fermentation inhibitors from the pretreated biomass product. Specifically, the pretreated biomass product derived from using the present method has fewer... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090053771 - Process for making fuels and chemicals from afex-treated whole grain or whole plants: A process for hydrolyzing whole grain or whole plant biomass after an Ammonia Fiber Explosion (AFEX) process step is described. The process preferably uses a biomass that is hydrolyzed using a different combination of enzymes (amylase, cellulase and hemicellulase) to sugars for fermentation to produce ethanol. Harvesting the whole plant... Agent: Ian C. Mcleod Ian C. Mcleod, P.C.
20090053773 - Reaction container and dna amplification reaction method: A linear recess is provided in a reverse side surface of a synthetic resin base plate 1, and a film 3 covers the linear recess. In this manner, a tunnel-shaped reaction chamber 12 surrounded by the film 3 and the base plate is configured. In addition, a protruding portion 31... Agent: Staas & Halsey LLP
20090053772 - Thermal cycler for pcr including temperature control bladder: Methods and devices for performing chemical reactions under controlled temperatures are described. In one embodiment, the devices provided by the invention comprise a housing dimensioned to hold a reaction chamber disposed within an interior volume of the housing. The reaction chamber has thermally conductive interior and exterior surfaces defining an... Agent: Andrews Kurth LLP
20090053774 - Methods, compositions and kits for one-step dna cloning using dna topoisomerase: Provided herein are methods, compositions, and kits useful for molecular cloning of, for example, blunt-ended DNA molecules using DNA topoisomerase. In certain embodiments, the methods comprise combining into a mixture a first polynucleotide, wherein said first polynucleotide comprises an origin of replication, a selectable marker, two topoisomerase recognition sequences, and... Agent: Jones Day
20090053775 - Copy dna and sense rna: The present invention relates generally to methods, compositions and kits for synthesizing sense RNA molecules from one or more RNA molecules of interest in a sample. In exemplary embodiments, the methods use a terminal tagging oligoribonucleotide (rTTO) to join a DNA sequence tag to the 3′-termini of first-strand cDNA molecules.... Agent: Casimir Jones, S.c.
20090053776 - Enzymic production of neoagarobiose: The present invention is directed to methods and systems of producing neoagarobiose, useful in whitening melanoma cells and in cosmetics, using polypeptides having neoagarobiosebiohydralase activity, including Aga86E from Saccharophagus degradans. The reaction can be enhanced by including other agarases, including Aga16B, also from S. degradans.... Agent: Dykema Gossett PLLC
20090053777 - Process for concentrated biomass saccharification: Processes for saccharification of pretreated biomass to obtain high concentrations of fermentable sugars are provided. Specifically, a process was developed that uses a fed batch approach with particle size reduction to provide a high dry weight of biomass content enzymatic saccharification reaction, which produces a high sugars concentration hydrolysate, using... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090053778 - Microorganisms for producing sulfur-containing compounds: The present invention relates to microorganisms and methods for producing at least one sulfur-containing compound.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090053779 - Mutant microorganism having improved production ability of branched amino acid and method for preparing branched amino acid using the same: The present invention relates to mutant microorganisms having improved productivity of branched-chain amino acids, and a method for producing branched-chain amino acids using the mutant microorganisms. More specifically, relates to mutant microorganisms having improved productivity of L-valine, which are produced by attenuating or deleting a gene encoding an enzyme involved... Agent: Merchant & Gould PC
20090053780 - Enzymatic oxidation of hmf: A method of converting hydroxymethylfurfural and is derivative species into hydroxymethylfurfural oxidation products is disclosed. The method includes contacting the hydroxymethylfurfural species in a mixture with an enzyme that oxidizes the hydroxymethylfurfural species while controlling hydrogen peroxide in the mixture. In one exemplary embodiment the enzyme is chloroperoxidase and the... Agent: Mcdermott Will & Emery LLP
20090053781 - Method for producing 2-hydroxy-4-(methylthio)butyric acid: m
20090053782 - Yeast cells having disrupted pathway from dihydroxyacetone phosphate to glycerol: Yeast cells are genetically modified to disrupt a native metabolic pathway from dihydroxyacetone to glycerol. In certain aspects, the yeast cell is of the genera Kluyueromyces, Candida or Issatchenkia. In other aspects, the yeast cell is capable of producing at least one organic acid, such as lactate. The yeast cells... Agent: Gary C. Cohn, PLLC
20090053783 - 3-hydroxypropionic acid and other organic compounds: Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.... Agent: Cargill, Incorporated
20090053784 - Expression of an active carrier from xylose in genetically modified saccharomyces cerevisae: The present invention confers to the ferementative yeast Saccharomyces cerevisiae, genetically modified by insertion of a nucleic acid sequence encoding a xylose and a glucose active transporter, the ability to assimilate xylose using a system of co-transport with protons exhibiting a high affinity for xylose. The invention is useful for... Agent: Sughrue Mion, PLLC
20090053785 - Methods and compositions for optimizing fermentation: Embodiments described include methods for maintaining the pH and alkalinity during industrial fermentation processes are described that foster optimal microorganism activities throughout the duration of the fermentation process. Magnesium based buffering agents having sufficient buffering capacity and applied at sufficient concentration levels required to neutralize the acidic content of fermentation... Agent: Black Lowe & Graham, PLLC
20090053786 - Prevention of disulfide bond reduction during recombinant production of polypeptides: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.... Agent: Goodwin Procter LLP Attn: Patent Administrator
20090053787 - Method for refolding enzymes: The invention provides methods for efficient recombinant expression, refolding, and purification of Beta-site APP cleaving enzyme (BACE) polypeptides. In various aspects, the method includes the steps of expressing a recombinant construct in bacteria, dissolving inclusion bodies with a denaturant at high pH in the presence of a reducing agent, diluting... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090053788 - Muscular dystrophy drug: The object of the present invention is to provide a drug having therapeutic effect on muscular dystrophy without lowering renal function. The therapeutic drug for muscular dystrophy of the present invention comprises a caldecrin or a caldecrin gene.... Agent: Fitch, Even, Tabin & Flannery
20090053789 - Particle binding: A method of binding bacteriophage to particles. The method comprising the steps of exposing the particles to an electrical discharge and then mixing the activated particles with the bacteriophage. The bacteriophage are then bound to the particles.... Agent: Thompson Hine L.L.P. Intellectual Property Group
20090053790 - Polypeptide having affinity for envelope virus constituent and use thereof in transferring substance into cell: Proteins are provided for transferring a protein, an antibody or another foreign substance into a cell without impairing the function or structure thereof; and methods of transferring a foreign substance into a cell in a time and quantity controllable manner at a high efficiency by using the above-described delivery protein... Agent: Wenderoth, Lind & Ponack, L.L.P.
20090053791 - Methods and composition for the production of orthogonal trna-aminoacyl trna synthetase pairs: This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.... Agent: Quine Intellectual Property Law Group, P.C.
20090053794 - Alleles of the rel gene from coryneform bacteria: An isolated mutant of a coryneform bacterium comprising a gene coding for a polypeptide having GTP-pyrophosphate kinase activity, wherein said polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids other than L-proline is present in position 38 or a corresponding or comparable position. In addition,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090053795 - Recombinant candida rugosa lipases: The present invention features an isolated nucleic acid that includes a mutant DNA encoding a Candida rugosa lipase, wherein the mutant DNA is 80% identical to a wild-type DNA encoding the Candida rugosa lipase, and includes at least 12 (e.g., 13, 15, 17, or all) universal serine codons corresponding to... Agent: Occhiuti Rohlicek & Tsao, LLP
20090053793 - Ethanol resistant and furfural resistant strains of e. coli fbr5 for production of ethanol from cellulosic biomass: Ethanol and furfural challenged strains of E. coli FBR5 exhibiting higher ethanol yield, productivity, and tolerance to both ethanol and furfural than FBR5 and methods for producing same.... Agent: John F. Letchford
20090053792 - Oxygen-regulated microorganisms: The present invention relates to novel strains of microorganisms with oxygen-regulated metabolism. The microorganisms have higher growth rates and are more efficient than parental strains. The microorganisms may be used to produce a variety of products of interests, such as recombinant proteins, nucleic acids, such as DNA, amino acids, and... Agent: Howrey LLP - Dc
20090053796 - Methods and compositions for culturing spirochetes and treating spirochetal diseases: The present invention relates to methods and compositions for culturing spirochetes and treating spirochetal diseases. For example, the present invention provides serum-free media for culturing spirochete bacteria in vitro. The present invention further provides methods for identifying spirochete susceptibilities to antimicrobials and antimicrobial compositions and cocktails. The present invention also... Agent: Casimir Jones, S.c.
20090053797 - Genetically modified host cells and use of same for producing isoprenoid compounds: The present invention provides genetically modified eukaryotic host cells exhibiting increased activity levels of one or more enzymes that generate precursors to be utilized by the mevalonate pathway enzymes, increased activity levels of one or more mevalonate pathway enzymes, prenyl transferase, and/or decreased levels of squalene synthase activity; such cells... Agent: Uc Berkeley - Otl Bozicevic, Field & Francis LLP
20090053798 - Method of improving storage stability of dried microorganisms: The present invention relates to a method of improving storage stability of dried microorganisms, such as dried lactic acid bacteria, by allowing the dried microorganisms to coexist with an L-arginine acidic amino acid salt, a composition comprising dried microorganisms and an L-arginine acidic amino acid salt and a process for... Agent: Fitzpatrick Cella Harper & Scinto
20090053799 - Trapping magnetic sorting system for target species: A system for sorting and trapping magnetic target species includes a microfluidic trapping module designed to receive and then temporarily hold magnetic particles in place within the module. The magnetic particles flowing into the module are trapped there while the other sample components (non-magnetic) continuously flow through and out of... Agent: Weaver Austin Villeneuve & Sampson LLP
20090053800 - Biomass treatment apparatus: An apparatus was developed for treatment of biomass in which reactants are added to biomass and the biomass mixture is moved through the apparatus without compacting under force of a non-compacting piston. Treatment systems used in this reactor result in effectively treated biomass that is particularly suitable for subsequent saccharification... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090053801 - Shallow multi-well plastic chip for thermal multiplexing: Disposable units in current use for performing PCR are limited by their heat block ramping rates and by the thermal diffusion delay time through the plastic wall as well as by the sample itself. This limitation has been overcome by forming a disposable plastic chip using a simple deformation process... Agent: Saile Ackerman LLC
20090053802 - Multipotent stem cells from peripheral tissues and uses thereof: This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an accessible source for autologous transplantation into CNS, PNS, and other damaged tissues.... Agent: Philip Swain, Phd C/o Gowling Lafleur Henderson
20090053803 - Apparatus and method for harvesting biologics from eggs: A method for harvesting biologics from eggs by which an egg is de-capped by positioning the egg in a reference opening so as to expose an upper section of said egg, then, while said egg is positioned within the reference opening, cutting the upper section of the egg by moving... Agent: Fox Rothschild LLP
20090053804 - Methods of reducing intracellular fats from mammalian cells: The present invention provides methods of reducing or clearing fat from mammalian cells. The method comprises culturing the cells in an environment that facilitates: 1) reduction of de novo fatty acid synthesis, 2) activation or synthesis of fatty acid oxidizing enzymes, and/or 3) export of lipids out of the cells.... Agent: Foley And Lardner LLP Suite 500
20090053805 - Post-partum mammalian placenta, its use and placental stem cells therefrom: The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush... Agent: Jones Day
20090053806 - Coating solution and method for capturing and preserving biological materials: The present invention is directed to a coating solution for capturing and preserving biological materials. The coating solution includes at least one saccharide. The coating solution may also include at least one other constituent, such as amino acids, complex proteins, surfactants, and mixtures thereof. The present invention is also directed... Agent: Husch Blackwell Sanders LLP
20090053808 - Compositions and methods for inhibiting the expression of anti-apoptopic genes: The present invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of an anti-apoptotic gene, comprising an antisense strand having a nucleotide sequence which is less that 25 nucleotides in length and which is substantially complementary to at least a part of an apoptotic gene, such as... Agent: Lowrie, Lando & Anastasi, LLP A2038
20090053807 - Insulin and igf-1 receptor agonists and antagonists: Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20090053809 - Retina-specific cells differentiated in vitro from bone marrow stem cells, the production thereof and their use: The invention relates to the production of retina-specific cells from human adult bone marrow stem cells by culturing bone marrow stem cells in the presence of a differentiation medium. The invention also relates to retina-specific cells and to the use of these cells for treating diseases associated with acquired or... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.
20090053810 - System and method for cultivating cells: The invention relates to a method of introducing a substance into a multi-layered cell factory. A substance is poured into a substance transferring device e.g. a funnel and a tube connected to the cell factory, which directly transfers the substance into the cell factory arranged with its layers extending substantially... Agent: Fish & Richardson P.C.
20090053811 - Reactor comprising an annular reaction space: A biological or chemical reactor (2) has an inner vessel (4) disposed within an outer vessel (6) and an annular space (16) defined therebetween in which fluid is to be contained. The fluid comprises reactants of a biological or chemical reaction. A reaction support (10a) is disposed in an opening... Agent: Alston & Bird LLP
20090053812 - Scleral cell strain: The present invention provides a scleral cell strain capable of expressing an exogenous immortalizing gene, and a production method thereof. Since the scleral cell strain of the present invention can produce a sufficient number of cells and has constant and continuous proliferative capacity, it can be advantageously utilized for the... Agent: Leydig Voit & Mayer, Ltd
20090053813 - Multiplexed electroporation apparatus: Described herein are platforms and consumables for performing gene/siRNA/protein/peptide delivery screens in high throughput, including an automation-compatible transfection methodology that can be used to gain entry of oligonucleotides, proteins, peptides and other non-permeable molecules (e.g., some small organic compounds) into cells. Electrical stimulation is provided to cells, e.g., neurons or... Agent: Saul Ewing LLP (baltimore) Attn: Patent Docket Clerk02/19/2009 > patent applications in patent subcategories. patent applications/inventions, industry category
20090047654 - Polymer affinity matrix, a method for the production and use thereof: A polymer affinity matrix for the binding of one or more substances in a fluid or removing said substance(s) from the fluid and/or decreasing the amount or concentration thereof in said fluid with a view to preventing, eliminating or reducing undesired activation of components in said fluid is described, as... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090047655 - Method of screening candidate drug: It is intended to provide a method of screening a candidate drug mainly metabolized by a drug metabolizing enzyme, CYP2D6, CYP2C9 or CYP2C19 with the use of a chimeric mouse carrying human hepatocytes transplanted thereinto, whereby it is determined whether or not the candidate drug is metabolized in a subject... Agent: Wenderoth, Lind & Ponack, L.L.P.
20090047659 - Amplification of hiv-1 sequences for detection of sequences associated with drug-resistance mutations: Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using the amplification oligonucleotides specific for gag and pol target sequences are... Agent: Christine A. Gritzmacher Patent Department
20090047660 - Antibodies for oncogenic strains of hpv and methods of their use: The subject invention provides antibodies, including polyclonal and monoclonal antibodies, that bind to E6 proteins from at least three oncogenic strains of HPV. In general, the antibodies bind to amino acids motifs that are conserved between the E6 proteins of different HPV strains, particularly HPV strains 16 and 18. The... Agent: Wilson Sonsini Goodrich & Rosati
20090047665 - Compositions for use in identification of adenoviruses: The present invention provides compositions, kits and methods for rapid identification and quantification of adenoviruses by molecular mass and base composition analysis.... Agent: Casimir Jones, S.c.
20090047657 - Detection method for latent viral infections and its kit for examination: The subject of the present invention is to provide a detection method for latent viral infections by detecting a gene product related to latent infections without going through an invasive procedure involving pain and bleeding, caused by skin biopsy and blood collection. Further, the subject of the present invention is... Agent: Kilyk & Bowersox, P.l.l.c.
20090047662 - Heteroduplex tracking assay: A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations... Agent: Thomas J. Kowalski, Esq. C/o Frommer Lawrence & Haug LLP
20090047658 - Methods and compositions for determining the pathogenic status of infectious agents: Methods and compositions for the detection of disease caused by infectious agents and microbes are provided. In particular, methods and compositions comprising novel combinations of nucleic acid amplification and drug susceptibility technologies are provided. In certain embodiments, the present invention enables the detection of infectious agents and microbes as well... Agent: King & Spalding LLP
20090047663 - Methods and compositions for identifying and characterizing hepatitis c: The invention provides novel methods and compositions for amplifying portions of the HCV genome. The nucleic acid sequences set forth as SEQ ID NOS:1-64 derived from HCV cDNA and functional equivalents thereof, kits containing same, and methods employing same, are useful for the identification and characterization of HCV in biological... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20090047656 - Molecular analysis of primary cells: The present invention provides a method of propagating cells of interest obtained from a biological specimen by a) enriching the cells under conditions that maintain sufficient cell viability; and b) propagating the cells under conditions effective to allow cell viability, proliferation and integrity.... Agent: Philip S. Johnson Johnson & Johnson
20090047661 - Quantitative hiv phenotype or tropism assay: The present invention concerns a method for predicting quantitative phenotype, e.g. gag-phenotype, integrase phenotype or tropism in a patient infected by Human Immunodeficiency Virus (HIV).... Agent: Philip S. Johnson Johnson & Johnson
20090047664 - Species detection methods and systems: The disclosure provides methods, systems and kits for cellular and subcellular identification in a rapid, throughput manner.... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP
20090047678 - Accelerated cascade amplification (aca) of nucleic acids comprising strand and sequence specific dna nicking: Particular aspects provide nucleic acid amplification and detection methods comprising: providing a reaction mixture containing a target nucleic acid with an amplifiable target sequence, forward and reverse external nick-directing primers (ND-primers), at least one internal ND-primer, a strand-displacing DNA polymerase, a nick-directing endonuclease for strand-specific cleavage of ND-primer-extension products, and... Agent: Davis Wright Tremaine, LLP/seattle
20090047675 - Compositions and methods for indentifying transforming and tumor suppressor genes: Provided herein are nucleic acids, proteins, vectors, cells, kits, devices and methods useful for identifying regulatable proteins that are able to complement components of cellular signaling pathways. Also provided are compositions and methods using these complementing genes directly as markers for cancer diagnosis or prognosis and as targets for anti-neoplastic... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20090047683 - Cyanine dye compounds: wherein W forms one or two fused 5- or 6-membered aromatic rings, α has a value of 0 or 1, n has a value of 0, or 1, X is O, S, or Se, and D is a pyridinium, or quinolinium moiety, provided that the compound has at least one... Agent: Invitrogen Corporation C/o Intellevate
20090047669 - Dna recombination junction detection: The present invention provides methods, compositions and kits for detecting the presence or absence of an integrated insertion polynucleotide.... Agent: Townsend And Townsend And Crew, LLP
20090047681 - Entropic trapping and sieving of molecules: Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially smaller than the size of the molecules to be... Agent: Wilson Sonsini Goodrich & Rosati
20090047684 - Gene and protein expression profiles associated with the therapeutic efficacy of irinotecan: The present invention includes gene and protein expression profiles indicative of whether a cancer patient is likely to respond to treatment with irinotecan. By identifying such responsiveness, a treatment provider may determine in advance those patients who would benefit from such treatment, as well as identify alternative therapies for non-responders.... Agent: Nuclea Biomarkers, LLC
20090047670 - Hybridization-based biosensor containing hairpin probes and use thereof: A sensor chip that includes: a fluorescence quenching surface; a nucleic acid probe that contains first and second ends with the first end bound to the fluorescence quenching surface, and is characterized by being able to self-anneal into a hairpin conformation; and a first fluorophore bound to the second end... Agent: Nixon Peabody LLP - Patent Group
20090047679 - Method and system for analyzing reactions using an information system: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.... Agent: Paul D. Yasger Abbott Laboratories
20090047674 - Method for nucleic acid isolation and amplification: The present invention provides methods and compositions for sequence-specific isolation of polynucleotide molecules from nucleic acid populations and subsequent amplification of isolated polynucleotide molecules or fragments thereof.... Agent: Seed Intellectual Property Law Group PLLC
20090047682 - Method of detecting and predicting bronchodilatory response to beta agonist: Present invention relates to a method for predicting an individual's bronchodilatory response to a β agonist. Present invention particularly relates to the detection of specific allelic variants of the β2AR gene and their use as pharmacogenetic markers towards response to β agonist.... Agent: Foley And Lardner LLP Suite 500
20090047680 - Methods and compositions for high-throughput bisulphite dna-sequencing and utilities: The invention relates to novel methods and compositions to produce DNA templates suitable for chemical modifications and high-throughput DNA-sequencing. A method of the invention relates to a DNA adaptor design where constituent deoxycytosines are substituted with 5-methyl-deoxycytosines rendering the resulting adaptor resistant to bisulphite mediated deamination. When said adaptor is... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090047666 - Methods and nucleic acids for the analysis of colon proliferative disorders: The invention provides methods, nucleic acids and kits for detecting colon cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.... Agent: Davis Wright Tremaine, LLP/seattle
20090047677 - Methods for generating a distribution of optimal solutions to nondeterministic polynomial optimization problems: The present invention overcomes problems in prior art DNA-based computing methods for solving non-deterministic polynomial optimization problems, by providing methods that derive the most probable answers in a statistically significant manner that makes the methods scalable with increases in the number of data inputs, and thus makes the methods practical.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090047673 - Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids: The invention provides miniaturized lateral flow chromatographic and lateral flow chromatographic microarray devices (LFM). The miniaturization of lateral flow nucleic acid detection achieved by the present invention offers reduced reagent use, femtomole sensitivity, excellent linear dynamic range, and rapid detection. Moreover, the small feature sizes of capture oligonucleotides renders the... Agent: Los Alamos National Security, LLC
20090047668 - Novel method for integrating genes at specific sites in mammalian cells via homologous recombination and vectors for accomplishing the same: A method for achieving site specific integration of a desired DNA at a target site in a mammalian cell via homologous recombination is described. This method provides for the reproducible selection of cell lines wherein a desired DNA is integrated at a predetermined transcriptionally active site previously marked with a... Agent: Pillsbury Winthrop Shaw Pittman, LLP
20090047667 - Salivary transcriptome diagnostics: The present invention concerns probes and methods useful in diagnosing, identifying and monitoring the progression of disease states through measurements of gene products in saliva.... Agent: Townsend And Townsend And Crew, LLP
20090047671 - Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories: The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the common bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection... Agent: Knobbe Martens Olson & Bear LLP
20090047676 - System and method for obtaining and maintaining high-resistance seals in patch clamp recordings: The invention provides a system, system components, and a method for rapidly obtaining and stably maintaining a cell in optimal contact with the cell-contacting surface of a sensor in a cell-based biosensor. In one aspect, the system maximizes the seal between a whole cell and the cell-contact surface of a... Agent: Edwards Angell Palmer & Dodge LLP
20090047672 - Telomerase rna subunit and methods of use thereof: The present invention provides a novel telomere associated RNA (hTERC-2) that mediates the DNA repair function of telomerase.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20090047686 - Methods for identifying and producing specific amino acid dependent antibodies and uses thereof: The present invention relates to methods for producing antibodies that are selective for one or two of the N-terminal amino acid residues of PTH, the antibodies made by such methods, and methods of using them to determine PTH levels while avoiding interference from N-terminally truncated PTH peptides.... Agent: Morrison & Foerster LLP
20090047685 - Ultrahighly sensitive determination reagent for c-reactive protein and determination method: The present invention is related to an ultrahighly sensitive determination reagent for C-reactive protein (CRP) for use in determination of CRP in a test sample with high sensitivity; and a CRP determination method using the reagent. A reagent for determining C-reactive protein containing an insoluble carrier particle loading an antibody... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090047687 - Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.... Agent: Edwards Angell Palmer & Dodge LLP
20090047689 - Autoantigen biomarkers for early diagnosis of lung adenocarcinoma: Provided herein are novel panels of biomarkers for the detection and diagnosis of lung adenocarcinoma, and methods and kits for detecting these biomarkers in samples of individuals suspected of having the disease. Also provided are methods of monitoring the progression of lung adenocarcinoma and methods of monitoring the efficacy of... Agent: Greenlee Winner And Sullivan P C
20090047690 - Method of analyzing white blood cells: The invention provides methods and compositions for identifying and counting lymphocytes in a biological sample, such as whole blood, by means of a probe comprising at least one binding compound specific for a T lymphocyte-specific marker, e.g. a CD2 or CD3, and at least one binding compound specific for CD45RA.... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20090047691 - Method for detecting a microorganism in a liquid sample: A method for the detection of a microorganism in a liquid sample, and in particular a method for the quantitative or semi-quantitative detection of a cariogenic microorganism such as a certain bacterium, for example in a saliva sample is described. Moreover, a test strip and test system with at least... Agent: Nixon Peabody LLP - Patent Group
20090047692 - Optically-detectable enzyme substrates and their method of use: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods... Agent: Invitrogen Corporation C/o Intellevate
20090047688 - Reagents, kits and methods for detecting biological molecules by energy transfer from an activated chemiluminescent substrate to an energy acceptor dye: Reagents, kits and methods for detecting biological molecules by energy transfer from an activated chemiluminescent substrate to an energy acceptor dye such as a J-aggregated dye are described.... Agent: Morris Manning Martin LLP
20090047693 - Luciferase detection assay system: The invention relates to methods and kits for detecting enzyme activity using bioluminescence. In particular, it relates to a novel assay system with increased light yield for a sensitive and convenient detection of luciferase activity, such as luciferase reporter enzyme activity. Provided is a method of detecting luciferase activity in... Agent: Hoffmann & Baron, LLP
20090047694 - Clinical intervention directed diagnostic methods: The invention provides methods for assessing the clinical status of a patient. In particular, the invention provides methods for identifying the presence of or likelihood of disease or disease recurrence. In practice, methods of the invention provide the ability to screen patients into one of three distinct clinical categories. Based... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090047696 - Detection of infectious prion protein by seeded conversion of recombinant prion protein: The present disclosure relates to methods and compositions for the detection of infectious proteins or prions in samples, including the diagnosis of prion related diseases. One embodiment is an ultrasensitive method for detecting PrP-res (PrPSc) that allows the use of recombinant PrP-sen (rPrP-sen) as a substrate for seeded polymerization. A... Agent: Klarquist Sparkman, LLP
20090047695 - Microdevices for high-throughput screening of biomolecules: Methods and devices for the parallel, in vitro screening of biomolecular activity using miniaturized microfabricated devices are provided. The biomolecules that can be immobilized on the surface of the devices of the present invention include proteins, polypeptides, nucleic acids, polysaccharides, phospholipids, and related unnatural polymers of biological relevance. These devices... Agent: Townsend And Townsend And Crew, LLP
20090047697 - Natriuretic peptides and placenta growth factor levels for risk stratification: The present invention relates to a method for determining a risk whether an individual will suffer from a cardiovascular adverse event as a consequence of cardiac stress testing, comprising the steps of (a) measuring, preferably in vitro, the level of placenta growth factor, wherein (b) if the level of the... Agent: Roche Diagnostics Operations Inc.
20090047698 - Reaction medium for vibrio bacteria: e
20090047699 - Fluorogenic enzyme activity assay methods and compositions using fragmentable linkers: Substrate compound-containing micelles and various compositions, kits and methods for their preparation and use are provided.... Agent: Mila Kasan, Patent Dept. Applied Biosystems
20090047703 - Erg-1 peptides and polynucleotides and their use in the treatment and diagnosis of disease: The present invention relates to peptide and polynucleotide fragments of ERG-1, and in particular, human ERG-1a (HERG-1a) and its isoforms, and their use in the treatment and diagnosis of disease, especially cardiac diseases, such as arrhythmias, and cancer.... Agent: Edell Shapiro & Finnan , LLC
20090047700 - Flourescence assay for mtp activity: The present invention is directed to methods for assaying microsomal triglyceride transfer protein (MTP) which are amenable to automation and high throughput screening. The assays may be used to measure MTP activity in cell and tissue homogenates as well as purified MTP. Also provided are methods of measuring levels of... Agent: Dilworth & Barrese, LLP
20090047702 - Method for identifying modulators of keah6 useful for treating alzheimer's disease: Methods for identifying modulators of KEAH6 are described. The methods are particularly useful for identifying analytes that antagonize KEAH6's effect on processing of amyloid precursor protein to Aβ peptide and thus useful for identifying analytes that can be used for treating Alzheimer disease.... Agent: Merck And Co., Inc
20090047701 - Method for screening antifungal agents: The present invention relates to a fungus which produces substantially no functional protein with regulating activity on the transcription of genes which are involved in cell wall stress response. It also relates to a method for screening for antifungal agents, in particular to antifungal agents which target the cell wall.... Agent: Foley And Lardner LLP Suite 500
20090047704 - Combination of a histological or cytological fixing agent and one or more photoactivatable compounds of the quinone family, in particular hypericin, hypocrellin a and hypocrellin b: The invention relates to the combination, in solution or in a kit, of a histological or cytological fixing solution and of one or more photoactivatable compounds of the family of quinones, in particular, hypericin, hypocrellin A and/or hypocrellin B. The invention also relates to a method for labeling cells or... Agent: Young & Thompson
20090047705 - Microorganism-derived psychrophilic endonuclease: A polypeptide having an endonuclease activity derived from a psychrophilic microorganism Shewanella sp. strain AC10, which exhibits high activity at low temperatures, can remove any nucleic acid present in a protein solution and can reduce the viscosity of a protein extract; and a nucleic acid encoding the polypeptide.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090047707 - Bacterial recombinant phytase: A novel phytase enzyme obtainable from B. Subtilis strain ARRMK-33 is disclosed. Also a novel method to produce recombinant phytase protein in prokaryotic cells is disclosed.... Agent: John Dodds
20090047708 - Highly productive recombinant yeast strains with modified galactose-regulated transcription: A recombinant yeast cell with modified galactose-regulated transcription, a use of such yeast cell, and products made using such yeast cell are disclosed. In such a recombinant yeast cell, a chromosomal gene encoding an enzyme for transformation of a transcription inductor into an inactive product is replaced by a gene... Agent: Smith Moore Leatherwood LLP
20090047709 - Novel endoribonuclease: A novel endoribonuclease activity exhibiting polypeptide; a nucleic acid coding for the polypeptide; a recombinant DNA comprising the nucleic acid; a transformant obtained by transformation using the recombinant DNA; a process for producing the polypeptide, characterized by including the steps of culturing the transformant and collecting the polypeptide from the... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090047706 - Process for producing dipeptides: The present invention provides: a protein having dipeptide-synthesizing activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant transformed with the recombinant DNA; a process for producing the protein having dipeptide-synthesizing activity using the transformant or the like; a process for producing a dipeptide using the protein... Agent: Fitzpatrick Cella Harper & Scinto
20090047710 - St3gal-1/st6galnac-1 chimeras: The present invention features compositions and methods related to increasing the solubility and enzymatic activity of GalNAc-α-2,6-sialyltransferase I (STÌGalNAcI) proteins expressed in prokaryotic host cells. Methods for increasing the solubility of STÌGalNAcI polypeptides include modifying cysteine residues, modifying N-linked glycosylation sites, deleting polypeptide regions, and constructing chimeric polypeptides comprising sequences... Agent: Townsend And Townsend And Crew, LLP
20090047711 - Bis-sulfhydryl macrocyclization systems: The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming linkers, and kits useful in their production.... Agent: Wilson Sonsini Goodrich & Rosati
20090047712 - Chemically cleavable phosphoramidite linkers: The present invention provides phosphoramidite linkers that are useful for the production of synthesizing two or more oligonucleotides in tandem. The inventive linkers have the following desirable properties: (i) enhanced stability to alkali conditions versus the linkers previously published, (ii) cleave to produce 5′ and 3′ ends that are fully... Agent: Lumen Patent Firm
20090047713 - Microfluidic cartridge and method of making same: The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are... Agent: Fish & Richardson P.C.
20090047714 - Oligonucleotides as temperature-sensitive inhibitors for dna polymerases: Aspects of the invention relate to the use of novel oligonucleotides as temperature-sensitive inhibitors for thermostable DNA polymerases. Some inhibitors exhibit temperature-dependent and, in some cases, reversible inhibitory property by changing the conformation of at least a portion of the oligonucleotides from double-stranded to single stranded or in some cases... Agent: Wilson Sonsini Goodrich & Rosati
20090047715 - Process for starch liquefaction and fermentation: The presently disclosed subject matter provides improved processes for processing starch from plant sources, including processes for starch liquefaction, for simultaneous liquefaction and saccharification, and for the preparation of ethanol. These processes can be performed without a pH adjustment and at relatively low temperatures. The processes can involve the use... Agent: Syngenta Biotechnology, Inc. Patent Department
20090047716 - Reduction processes for the preparation of ezetimibe: Processes for preparing ezetimibe-related compounds with a ketoreductase and for purifying ezetimibe are disclosed.... Agent: Kenyon & Kenyon LLP
20090047717 - Enzyme-catalyzed polycarbonate and polycarbonate ester synthesis: An enzymatic process for preparing aliphatic polycarbonates via terpolymerization or transesterification using a dialkyl carbonate, an aliphatic diester, and an aliphatic diol or triol reactant. A catalyst having an enzyme capable of catalyzing an ester hydrolysis reaction in an aqueous environment is subsequently added to the reaction mixture. Next, polymerization... Agent: Smith, Gambrell & Russell
20090047718 - Methods and compositions for producing solvents: Described herein are methods, compositions and synthetic biology approaches for solvent production, including but not limited to butanol production. Described herein are recombinant bacteria and yeast strains which may be used in production of a solvent, including but not limited to butanol, from lignocellulosic and other plant-based feedstocks. Described herein... Agent: Morrison & Foerster LLP
20090047719 - Methods and organisms for the growth-coupled production of 1,4-butanediol: The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory to coupling 1,4-butanediol production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby theone or more gene... Agent: Mcdermott, Will & Emery
20090047720 - Method for extracting oil from a water and solids composition, method for the production of ethanol, and ethanol production facility: The present disclosure includes a method for processing a beer stream for the recovery of oil. The method include a step of extracting oil from a beer stream into an organic phase comprising an organic solvent to provide in the organic phase at least a portion of the oil. In... Agent: Merchant & Gould PC
20090047721 - Renewable diesel and jet fuel from microbial sources: The invention provides methods of manufacturing alkanes from triglyceride oils produced through fermentation of oil-bearing microbes. The processes provided herein can utilize a variety of carbohydrate feedstocks including cane bagasse, sugar beet pulp, corn stover, glycerol, corn starch, sorghum, molasses, waste glycerol, and other renewable materials. These processes further comprise... Agent: Townsend And Townsend And Crew, LLP
20090047722 - Systems, devices, and methods for biomass production: Systems, devices, and methods for releasing one or more cell components from a photosynthetic organism. A bioreactor system is operable for growing photosynthetic organisms. Some of the methods include contacting the photosynthetic organism with an energy-activatable sensitizer, and activating the energy-activatable sensitizer, thereby releasing a cellular component from at least... Agent: Seed Intellectual Property Law Group PLLC
20090047723 - Method for purification of factor vii: A method for purifying recombinant Factor VII (rFVII) or recombinant activated Factor VII (rFVIIa), comprising subjecting the rFVII or rFVIIa to liquid chromatography on a hydroxyapatite (HAP) column.... Agent: Bayer Healthcare LLC
20090047724 - Method for the isolation of nucleic acids from any starting material: A composition suitable for the isolation of a nucleic acid from a material containing the nucleic acid contains at least one buffer with a chaotropic component; at least one proteolytic enzyme; at least one buffer with an non-chaotropic component; at least one alcoholic component; and a detergent.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090047725 - Method for increasing asparaginase activity in a solution: A stable asparaginase solution is disclosed. In one aspect, drinking water is treated to reduce the level of chlorine to enhance the residual enzyme activity of asparaginase. The treatment can occur by removing chlorine constituents or by supplying additives that reduces the level of chlorine. Additives can include reducing agents... Agent: Carstens & Cahoon, LLP
20090047728 - Adenoviral vectors for influenza virus production: The invention provides adenovirus and retrovirus vectors useful to prepare influenza virus. Also provided is a canine RNA polymerase I promoter and vectors having that promoter.... Agent: Schwegman, Lundberg & Woessner, P.A.
20090047726 - Novel clostridium perfringens bacteriophage and uses thereof: The present invention is directed to isolated bacteriophage having strong lytic activity against strains of Clostridium perfringens, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth of Clostridium perfringens in various settings.... Agent: Hunton & Williams LLP Intellectual Property Department
20090047727 - Novel clostridium perfringens bacteriophage and uses thereof: The present invention is directed to isolated bacteriophage having strong lytic activity against strains of Clostridium perfringens, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth of Clostridium perfringens in various settings.... Agent: Hunton & Williams LLP Intellectual Property Department
20090047729 - Transport media: A transport media, particularly for fastidious microorganisms, has a concentration of activated charcoal less than 10 grams per litre of water. This maintains viability of the microorganisms while permitting Gram interpretation of the specimen.... Agent: Wood, Phillips, Katz, Clark & Mortimer
20090047730 - Methods for controlling dust and creating bio-crust: Methods for controlling dust and other particulates using photosynthetic organisms to create a bio-crust. The methods include applying algae to a site under conditions suitable for forming a layer over the site that provides dust control.... Agent: Quarles & Brady LLP
20090047731 - Cellular electrophysiological measurement device and method for manufacturing the same: A cellular electrophysiological measurement device includes a thin plate and a frame. The thin plate has a first surface with a depression and a second surface with a through-hole. The frame is in contact with an outer periphery on the second surface of thin plate. The thin plate has a... Agent: Ratnerprestia
20090047732 - Biodegradation of oxyanions such as perchlorate on ion exchange resins: Improved systems and methods for removing the load of perchlorate and other oxyanions off of ion exchange resins through bioregeneration are disclosed. The improved systems and methods rely upon direct contact between the resin and a liquid product containing enrichment cultures of or pure strains of perchlorate-destroying microorganisms. Controlled temperatures... Agent: Foley & Lardner LLP
20090047733 - Avidin-pseudotyped viral vectors and their use: The present invention pertains to an avidin-pseudotyped virus, and especially baculovirus, useful for delivery of foreign genes etc. The present invention also pertains to vectors comprising respective cassettes for pseudotyping, mammalian gene expression and insect gene expression in baculovirus.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090047734 - Method of separation of deoxyribonucleic acids: The present invention relates to a method of separating nucleic acids from a liquid, which comprises providing a mobile phase comprising nucleic acids and a first salt, which forms lyotropic ions when dissolved; passing said mobile phase across a hydrophobic interaction chromatography (HIC) matrix to adsorb deoxyribonucleic acid(s); passing an... Agent: Ge Healthcare Bio-sciences Corp. Patent Department
20090047735 - Antibodies against human g-protein chemokine receptor (ccr5) hdgnr10: The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells,... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20090047736 - Human t1r2 nucleic acid sequences and polypeptides: Binding assays for identifying compounds that modulate human T1R2 polypeptide associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R2 polypeptide or the modulation of the specific binding of a compound that specifically binds to a human T1R2 polypeptide. The binding assays may include... Agent: Hunton & Williams LLP Intellectual Property Department
20090047737 - Human ly6-big molecules and methods of use: The present invention is directed to human Ly6-BIG molecules and their use in diagnostic, prognostic, and treatment methods for colon, lung and other cancers, in preventing the reoccurrence of such cancers, and in diagnostic, prognostic, and treatment methods for autoimmune disorders and AIDS.... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.
20090047738 - Feeder cell derived from tissue stem cell: It is an object of the present invention to provide a feeder cell with less variation in quality. The present invention relates to a feeder cell derived from a tissue stem and/or progenitor cell. A method of preparation of the feeder cell, a method of preparation of a cultured cell... Agent: Clark & Elbing LLP
20090047739 - Direct differentiation method for making cardiomyocytes from human embryonic stem cells: This invention provides a new procedure for generating cardiomyocyte lineage cells from embryonic stem cells for use in regenerative medicine. Differentiating by way of embryoid body formation or in serum is no longer required. Instead, the stem cells are plated onto a solid substrate, and differentiated in the presence of... Agent: Geron Corporation Attn. David J. Earp
20090047740 - Culture aid for cells and tissues: A biological culture medium provides a three-dimensional framework for cell growth. The medium comprises a film and a matrix.... Agent: Bell, Boyd, & Lloyd LLP
20090047741 - Compositions and methods comprising a ligand of chemerin r: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related... Agent: Edwards Angell Palmer & Dodge LLP
20090047742 - Inhibition of mrna interferase-induced apoptosis in bak-deficient and bak- and bax-deficient mammalian cells: Ribonucleases, antibiotics, bacterial toxins and viruses inhibit protein synthesis, which results in apoptosis in mammalian cells. How the BCL-2 family of proteins regulates apoptosis in response to shutoff of protein synthesis is not known. According to the present invention, an Escherichia coli toxin MazF inhibited protein synthesis by cleavage of... Agent: Patent Docket Administrator Lowenstein Sandler P.C.02/12/2009 > patent applications in patent subcategories. patent applications/inventions, industry category
20090042179 - Fluorescence reflection imaging device with two wavelengths: A first light source has a first wavelength corresponding to an excitation wavelength of a fluorophore. The excitation wavelength and an emission wavelength of the fluorophore delineate a predetermined interval. A second light source has a second wavelength offset with respect to the first wavelength so as to be outside... Agent: Oliff & Berridge, PLC
20090042180 - System for sampling and tracking plant material: A system and method for processing, i.e., sampling and tracking, plant material requires the ability to identify each plant in a plurality of plants. Initially, samples are taken from selected plants and are collected in respective storage locations in a magazine. During sampling, the identity of the plant source for... Agent: Syngenta Biotechnology, Inc. Patent Department
20090042182 - Detection of bovine viral diarrhea virus in tissue samples: The present invention relates to a method of detecting whether a target animal is Bovine Viral Diarrhea Virus (BVDV) positive or negative by determining whether a gp48 protein-specific reagent binds to a gp48 Bovine Viral Diarrhea Virus protein or protein fragment, which retains antigenic specificity, from a target animal's tissue... Agent: Nixon Peabody LLP - Patent Group
20090042181 - Nucleic acid and gene derived from novel hcv strain and replicon-replicating cell using said gene: The present invention relates to a gene derived from a novel fulminant hepatitis C virus strain, an HCV replicon RNA with a high replication efficiency obtained using the gene, and an HCV replicon-replicating cell transfected with the replicon RNA. When the HCV replicon RNA and the HCV replicon-replicating cell of... Agent: Birch Stewart Kolasch & Birch
20090042204 - Acne lesion biomarkers and modulators thereof: The present invention relates to acne lesions biomarkers/genes expression products pattern and particularly inflammatory acne lesions biomarkers and their uses, modulators thereof and the use of modulators for acne treatment or associated disorders. Invention also concerns in vitro diagnostic methods.... Agent: Buchanan, Ingersoll & Rooney PC
20090042188 - Agent for differentiating hematopoietic stem cell into natural killer cell comprising vdup1 protein or gene encoding the same, and a method of differentiating hematopoietic stem cell into natural killer cell using thereof: The present invention is related to an agent for differentiating hematopoietic stem cell into natural killer cell comprising VDUP1 protein or gene encoding the same, and a method of differentiating hematopoietic stem cell into natural killer cell using thereof. The present invention reveals for the first time that the VDUP1... Agent: Greenlee Winner And Sullivan P C
20090042208 - Assays for erectile and bladder dysfunction and vascular health: Assays are provided for erectile and bladder dysfunction and vascular health (e.g., cardiovascular disease, hypertension), where the assays detect the expression of one or more of the human Vcsa1 gene family. The assays are also useful for monitoring the efficacy of treatment of these disorders.... Agent: Amster, Rothstein & Ebenstein LLP
20090042193 - Assays for measuring nucleic acid binding proteins and enzyme activities: Processes for measuring DNA or RNA binding proteins, specific nucleic acids, as well as enzyme activities using labeled nucleic acids of labeled protein/peptide molecules are provided.... Agent: Foley & Lardner LLP
20090042201 - Biomarkers for multiple sclerosis and methods of use thereof: Disclosed are biomarkers, the expression of which is differentially regulated in subjects with multiple sclerosis (MS) as compared to subjects that do not have MS. Also described are methods of identification of such biomarkers, and methods of using such biomarkers as targets for the development and identification of therapeutic compounds... Agent: Sheridan Ross PC
20090042200 - Cellomics system: In labeling a cell, and separating and collecting the cell according to a degree of the labeling using a cell separator, effects on the cell is minimized and the use of the collected cell is facilitated, thereby, when labeling a cell, the cell is labeled in the state where interaction... Agent: Antonelli, Terry, Stout & Kraus, LLP
20090042187 - Compositions and methods for predicting outcome of treatment: This invention is directed to compositions and their uses for detection of markers. Such markers may be useful in the understanding of the underlying molecular event leading to a condition or a disease in a subject. These markers may also be useful for characterization of neoplastic cells and cancer cells... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090042205 - Fluorescence detection of dna breaks using molecular oscillators: A method to detect DNA breaks includes providing a mixture of fluorescence energy transfer molecular oscillators and a DNA sample. The FET oscillator is a synthetic oligonucleotide that has a topoisomerase recognition sequence, a fluorescence donor and a fluorescence acceptor. The synthetic oligonucleotide is bound to a type I topoisomerase... Agent: Winstead PC
20090042189 - Increased sensitivity of nucleic acid-based detection of organisms by fractionation of target genomes: A method of analyzing a sample for detection of presence or absence of an organism of interest in the sample comprising (a) obtaining a sample; (b) subjecting the sample to a disruption treatment sufficient to fractionate any nucleic acid sequences present in the sample; and (c) detecting for presence or... Agent: Rehber Edward F E I Du Pont De Nemours And Company
20090042207 - Intracellular expression and delivery of sirnas in mammalian cells: The present invention relates to compositions and methods for intracellular expression and delivery of siRNAs in mammalian cells. The siRNA is transcribed intracellularly as a double stranded RNA of about 18 to about 25 base pairs long from an expression cassette. Intracellular expression of siRNA is effective at reducing or... Agent: Casimir Jones, S.c.
20090042186 - Mapping new sites for antibiotic action in the ribosome: The present invention provides a method of mapping and identifying new sites for antibiotic action in the ribosome of a microorganism. The method comprises: (a) providing a random mutant library of the rRNA genes of the microorganism prepared by randomly mutating the rRNA genes of the microorganism; (b) enriching the... Agent: Polsinelli Shalton Flanigan Suelthaus PC
20090042203 - Mass spectrometric methods for detecting mutations in a target nucleic acid: Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and mutations in the molecules are provided.... Agent: Grant Anderson LLP C/o Portfolioip
20090042197 - Method for detecting and amplifying nucleic acid: Solution There is provided a method for detecting a nucleic acid contained in a sample, comprising the step of adding at least one substance selected from the group consisting of polyphenols, polyhydric alcohols, sugar acids, sugar alcohols, and hydrophilic biodegradable polymers to a sample, the step of complementarily binding an... Agent: Alston & Bird LLP
20090042198 - Method for measuring concentration of nucleic acids: A method for measuring a concentration of nucleic acids is described. The method includes providing bioprobe molecules that include single-stranded nucleic acids, wherein the bioprobe molecules are conjugated with magnetic beads in a solution. A sample of single-stranded target nucleic acids is added to solution, where the single-stranded target nucleic... Agent: J C Patents, Inc.
20090042190 - Method of detecting gene: A method of detecting a gene including immobilizing a primer for DNA elongation onto an insoluble carrier having on the surface thereof a polymer substance containing a first unit having a phosphorylcholine group and a second unit having a carboxylic acid-derived group having an electron-attractive substituent bound to a carbonyl... Agent: Smith, Gambrell & Russell
20090042184 - Method of diagnosing cancer and reagents therefor: The present invention provides methods for diagnosis and monitoring the efficacy of treatment of a cancer. More particularly, the methods of the invention comprise detecting an enhanced degree of chromatin modification within Chromosome 2 of the human genome from about map position 2q14.1 to about map position 2q14.3 in a... Agent: Bozicevic, Field & Francis LLP
20090042199 - Methods and materials relating to cd84-like polypeptides and polynucleotides: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CD84-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human spleen (Hyseq clone identification numbers 2938352 (SEQ ID NO: 1)). Other aspects of... Agent: Nuvelo, Inc
20090042195 - Methods and systems for screening for and diagnosing dna methylation associated abnormalities and sex chromosome aneuploidies: Methods and systems for population screening and diagnostics are provided. In particular methods and systems for population screening of individuals for genetic disorders due to alterations in DNA methylation and for the diagnostic testing for such disorders are provided.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP
20090042196 - Methods for identifying multiple dna alteration markers in a large background of wild-type dna: Methods for simultaneously surveying the status of a large number of DNA mutation markers are described. In addition, methods for simultaneously determining the methylation status at multiple sites of a collection of genes, in a single assay, are described.... Agent: Fay Sharpe LLP
20090042206 - Multiplexed analyses of test samples: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test... Agent: Swanson & Bratschun, L.L.C.
20090042185 - Novel polymorphism in bovine prion protein gene sequence: A specific, non-synonymous SNP in the Prnp gene encoding the bovine prion protein affects the susceptibility of bovine animals to bovine spongiform encephalopathy (BSE). Depending on the number of octapeptide repeat units present in the Prnp gene, the position of the SNP is either nucleotide 631 of exon 3 (codon... Agent: Usda-ars-office Of Technology Transfer National Ctr For Agricultural Utilization Research
20090042194 - Predicting a response to risperidone: The invention relates generally to the relative effect of specific genetic polymorphisms in predicting the clinical outcome of risperidone therapy in patients suffering from a psychiatric disease such as schizophrenia.... Agent: Edwards Angell Palmer & Dodge LLP
20090042202 - Prostate-specific polypeptide pamp and encoding nucleic acid molecules: The present invention relates to novel prostate specific nucleic acid molecules and polypeptides and related methods for diagnosing or predicting susceptibility to a prostate neoplastic condition.... Agent: Mcdermott, Will & Emery
20090042191 - System and method for secure document printing and detection: A method for authenticating and verifying an item to be genuine is described. The method for authenticating the item comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to ink within an ink cartridge or a toner compound within a toner housing. The... Agent: Virtual Legal, P.C. Michael A. Kerr
20090042192 - Universal amplification of fragmented rna: The invention relates to methods of using fragmented RNA, such as RNA obtained from archived fixed paraffin-embedded tissue material (FPET RNA) or other clinically biopsied tissue specimens for universal gene expression profiling.... Agent: Genomic Health, Inc. C/o Kathleen Determann
20090042183 - Use of pcr-based techniques to analyze compositions of botanicals: Methods for use in identifying the individual biological components present in a botanical mixture are provided. Using a combination of genomic-locus specific PCR, single strand conformation polymorphism, and sequence analysis, the biologic components of a botanical composition are identified without prior knowledge as to which components may be present.... Agent: Bozicevic, Field & Francis LLP
20090042214 - Beta2-microglobulin and c reactive protein (crp) as biomarkers for peripheral artery disease: The present invention relates to use of β-2-microglobulin (B2M or β2M) and C-reactive protein (CRP) levels as biomarkers of peripheral artery disease and/or atherosclerosis.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP
20090042212 - Detection of primary infections with pathogens: The present invention relates to fusion proteins: suitable as test antigens in the detection of infections with pathogens, particularly of primary infections with pathogens. Further, the invention relates to methods for detecting and differentially determining antibodies, particularly IgM antibodies resulting from an infection with a pathogenic organism. Furthermore, test reagents... Agent: Roche Diagnostics Operations Inc.
20090042211 - Method for the selective detection of pathological protein depositions: The invention relates to a method for the selective detection of the presence and/or quantity of pathological protein depositions.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20090042213 - Methods and compositions for detecting thyroglobulin in a biological sample: The invention provides a method and reagents for determining the presence and/or amount of human thyroglobulin in a biological sample. In one embodiment, the method comprises (a) digesting a biological sample containing proteins to provide peptide fragments; (b) contacting the digested sample with a binding reagent comprising a plurality of... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20090042209 - Neoplasia-specific tnox isoforms and methods: All neoplastic cells express one or more members of a unique family of cell surface ubiquinone (NADH) oxidase proteins with protein disulfide-thiol interchange activity (ECTO-NOX proteins) that are characteristically inhibited by quinone site inhibitors with anti-cancer activity. Cancers of different cellular or tissue origins express different tNOX cancer isoforms or... Agent: Greenlee Winner And Sullivan P C
20090042210 - Sensors and methods for detecting diseases caused by a single point mutation: A method for generating antibodies preferable to either a normal protein and a mutated form of the normal protein, respectively, where a mutation associated with the mutated form includes either a single point mutation or a small number of point mutations where the method includes creating first and second antigenic... Agent: Greer, Burns & Crain
20090042215 - Cell permeability assay in a living array of multiple cell types and multiple layers of a porous substrate: The present invention provides a device for determining drug efficacy on target cells comprising (1) a porous support (B) having first and second surfaces and at least one area with a plurality of through-going channels, wherein said area comprises on said first surface at least one region, which can be... Agent: Amster, Rothstein & Ebenstein LLP
20090042216 - Method for purifying proteins and/or biomolecule or protein complexes: The present invention relates to a method for detecting and/or unifying proteins and/or biomolecule or protein complexes, as well as fusion proteins, nucleic acids, vectors and cells suitable for this method.... Agent: Jones Day
20090042220 - Method for monitoring collagen type ii degradation in cartilage: A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals utilizes an immunoassay to detect fragments of collagen type II resulting from collagenase activity comprising an antibody directed against an epitope... Agent: Jacobson Holman PLLC
20090042219 - Novel transporter protein in mammal and utilization of the same: The present invention provides a lipid membrane that contains a polypeptide consisting of the amino acid sequence of SEQ ID NO: 2, 4, 6, 8, or 22. Use of the present invention enables screening for a chemical which regulates excretion of a chemical and/or a waste. Furthermore, use of the... Agent: King & Spalding
20090042221 - Precise efficacy assay methods for active agents including chemotherapeutic agents: An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying the best... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090042222 - Peptides for detection of antibody to anaplasma phagocytophilum: The invention provides compositions and methods for the detection and quantification of A. phagocytophilum (formerly known as Ehrlichia equi) antibodies and antibody fragments.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090042217 - Methods and kits for determining blood coagulation: A method of determining a coagulation status of a blood sample is provided. The method comprising determining an expression and/or activity ratio of Tissue Factor (TF) to Tissue Factor Pathway Inhibitor (TFPI) in cellular microparticles of the blood sample, wherein the ratio is indicative of the coagulation status of the... Agent: Martin D. Moynihan Prtsi
20090042218 - Labeling enzyme: The present invention relates to a labeling enzyme and a method of detecting and/or quantifying a target substance using this labeling enzyme. The present invention provides a labeling enzyme that catalyzes a reaction of gelling a substrate. By measuring changes in physical properties such as the film thickness and/or refractive... Agent: Nixon & Vanderhye, PC
20090042226 - Identification and cloning of a full-length human clnk-related gene, mist (mast cell immunoreceptor signal transducer): The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or... Agent: Louis J. Wille Bristol-myers Squibb Company
20090042225 - Method for selecting therapeutic agents for cancer treatment: An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying. One particularly... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090042223 - Methods for detection of immunosuppressant drugs: Methods and reagents are disclosed for enhancing the bioavailability of a hydrophobic drug, and in some embodiments for determining a hydrophobic drug, in a sample suspected of containing a hydrophobic drug. A combination is formed in a medium where the combination comprises the sample, a hemolytic agent where a determination... Agent: Dade Behring Inc. Legal Department
20090042224 - Methods for diagnosis and/or prognosis of ovarian cancer: In one embodiment, methods are provided for assessing the presence of mesothelin-expressing tumor cells in a human subject. In another embodiment, methods are provided for monitoring the efficacy of treatment of a human cancer patient diagnosed with a mesothelin-expressing tumor.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20090042227 - Amino(oligo)thiophene dyes, preparation thereof, and optical methods of use: Amino(oligo)thiophene dyes useful for studying the electrophysiology of organelles, cells, and tissues are described. Compared to previously known dyes, the amino(oligo)thiophene dyes exhibit improved (faster) response to membrane potential changes, as well as the ability to be excited by 1064 nanometer femtosecond pulses. Methods of preparing the amino(oligo)thiophene dyes are... Agent: Cantor Colburn, LLP
20090042228 - Nt-proanp and nt-probnp for diagnosing cardiac diseases: Described are methods for diagnosing a cardiac disease, particularly an acute cardiac event, in a patient presenting with symptoms of acute cardiac decompensation, comprising the steps of (a) measuring, typically in vitro, the level of NT-proBNP (N-terminal brain natriuretic peptide) or a variant thereof in a sample from the patient,... Agent: Roche Diagnostics Operations Inc.
20090042230 - Flea allantoinase proteins and uses thereof: The present invention relates to flea allantoinase proteins; to flea allantoinase nucleic acid molecules, including those that encode such flea allantoinase proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid... Agent: Heska Corporation Legal Department
20090042231 - Fret protease assays for clostridial toxins: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum... Agent: Allergan, Inc.
20090042229 - Platelet biomarkers for cancer: The present invention relates to the fields of immunology and biochemistry. Particularly, the present invention describes methods, devices and kits for early detection of clinical conditions having associated changes in systemic angiogenic activity, particularly cancers, inflammatory conditions, infections, and events associated with pregnancy and abortion.... Agent: Foley And Lardner LLP Suite 500
20090042232 - Mutant protein having diaphorase activity: A mutant diaphorase capable of having lower potential energy than that of wild-type diaphorase of sequence ID No. 1 when forming a complex with a coenzyme, flavin mononucleotide.... Agent: Bell, Boyd & Lloyd, LLP
20090042237 - Aptamer based point-of-care test for glycated albumin: The test is performed using a disposable strip or cassette that contains the testing reagents and the results are measured in a measuring instrument that automatically reads, calculates and displays the final result. The results of tests performed over a period of time are stored in the instrument's memory and... Agent: Henry John Smith
20090042238 - Method of evaluating cell function, system for evaluating cell function, fluorescent microscope system, phototherapy method and phototherapy system: A proposition is to accurately evaluate a phototoxic property (cell function) concerning a living cell. To this end, an evaluating method of cell function includes the operations of dyeing a specific site of the living cell with a fluorescent dye, irradiating the living cell with light to measure changes in... Agent: Oliff & Berridge, PLC
20090042236 - Method of identifying hydrogen evolving diazotrophic bacteria: MohC is required for expression of uptake hydrogenase in A. vinelandii and inactivation of this gene results in H2 evolution via nitrogenase 3. Since MohC− mutants are tungsten tolerant under nitrogen-fixing conditions, tungsten can be used to select spontaneous tungsten-tolerant mutants of nitrogen-fixing bacteria that are genetically uncharacterized. A major... Agent: Usda-ars-office Of Technology Transfer National Ctr For Agricultural Utilization Research
20090042233 - Novel protein member of the ras/mapk pathway, antibodies thereof and methods and kits of using same: A polypeptide comprising a SAM domain, the sequence of said SAM domain being as set forth in SEQ ID NO: 33.... Agent: Goudreau Gage Dubuc
20090042239 - Particle fusing systems and methods using acoustic radiation pressure: The present invention comprises methods and systems that use acoustic radiation pressure.... Agent: Peacock Myers, P.C.
20090042235 - Photoregulated peptide, and method for regulation of peptide-protein complex formation using the photoregulated peptide: The present invention provides a method of photoregulating the formation of a peptide-protein complex by using a novel peptide in which a structural change for recognizing a protein is photoregulated, in the formation of a complex between a peptide capable of recognizing a protein and a protein of interest. A... Agent: Cheng Law Group, PLLC
20090042234 - Ultra sensitive biosensor for detecting bio-signal transmitters, and detector and detecting method using the same: The present invention relates to a novel use of a transfected cell as a biosensor, wherein the transfected cell expresses a receptor specific to a bio-signal transmitter, and a highly sensitive detector and a highly sensitive detecting method of a bio-signal transmitter using the biosensor. The bio-signal transmitter detecting technique... Agent: LexyoumeIPGroup, LLC
20090042240 - Rapid detection of antimicrobial drug residues: The present invention relates to a novel method for the rapid detection of the presence or absence of antimicrobial drug residues belonging to the class of the quinolones in liquid samples such as milk, meat juice, serum, urine, blood, eggs or extracts obtained from animal tissues or food products.... Agent: Nixon & Vanderhye, PC
20090042241 - Microfluidic device: Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations. One particular embodiment relates a device and methods of using the... Agent: Davis Wright Tremaine LLP/los Angeles
20090042242 - Two-step gram staining method: The present invention provides a two-step Gram staining method. The method is conducted by using a clean slide, followed by adding 10˜30 μl primary stain from a reagent kit, adding an equivalent amount of specimens uniformly on said slide without drying and frame fixing, then immediately adding 30˜60 μl counter-stain... Agent: Wpat, PC Intellectual Property Attorneys
20090042243 - Automated tissue staining system and reagent container: An automated staining system and a reagent container designed for use with the automated staining apparatus. The reagent container includes a reagent containment section capable of containing a volume of a reagent. The reagent containment section includes an upper wall and a base wall that are spaced apart along an... Agent: Wood, Herron & Evans, LLP
20090042244 - Protein expression yield enhancement in cell-free protein synthesis systems by addition of antifoam agents: Compositions and methods are provided for the in vitro synthesis of biological molecules in reaction mixtures comprising anti-foam agents. The reaction mix comprising antifoam agent may be a scaled up reaction, e.g. in reaction volume greater than at least about 15 ul. Reactions may be performed in various reactors, as... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP
20090042250 - Methods and compositions for inactivating alpha 1,6 fucosyltransferase (fut8) gene expression: Disclosed herein are methods and compositions for inactivating a FUT8 gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.... Agent: Robins & Pasternak
20090042246 - Methods for the production and secretion of modified peptides: The invention relates to the production of heterologous polypeptides in a recombinant host cell. More specifically, it relates to the production and secretion of peptides, such as biologically active peptides, that are modified by one or more lantibiotic-synthesizing enzymes. Provided is a nucleic acid construct encoding a polypeptide comprising 1)... Agent: Trask Britt
20090042245 - Methods of overexpression and recovery of porcine circovirus type 2 orf2: An improved method for recovering the protein expressed by open reading frame 2 from PCV2 is provided. The method generally involves the steps of transfecting recombinant virus containing open reading frame 2 coding sequences into cells contained in growth media, causing the virus to express open reading frame 2, and... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation
20090042247 - N-acetylglucosaminyltransferase vb coding sequences, recombinant cells and methods: A previously unknown mammalian UDP-N-acetylglucosamine:α-6-D-mannoside β-1,6-N-acetylglucosaminyl-transferase (termed GlcNAc T-Vb herein) coding sequence, protein, recombinant host cells and antibodies which specifically bind GlcNAc T-Vb are described. In particular, GlcNAc T-Vb of mouse is disclosed.... Agent: Greenlee Winner And Sullivan P C
20090042249 - Vectors for cloning: p
20090042252 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department
20090042251 - Chimeric fusion protein: The invention discloses the cloning, expression and uses of a chimeric fusion protein with superior chaperone and folding activities compared to the wild type chaperones. This invention relates to a chimeric fusion protein encoded by a recombinant DNA molecule comprising nucleotide sequences coding for a polypeptide binding segment of a... Agent: Roche Diagnostics Operations Inc.
20090042253 - Use of perfusion to enhance production of fed-batch cell culture in bioreactors: The invention relates to methods of improving protein production, e.g., large-scale commercial protein production, e.g., antibody production, utilizing a modified fed-batch cell culture method comprising a cell growth phase and a polypeptide production phase. The modified fed-batch cell culture method combines both cell culture perfusion and fed-batch methods to achieve... Agent: Fitzpatrick Cella (wyeth)
20090042254 - Expression of soluble antibody fragment by truncation of ch1 domain: Improved expression of active antibody fragments (Fabs) is achieved by truncating a heavy chain constant region. Truncation of the CH1 domain of a Fab fragment can increase yield of soluble active antibody fragment in Pseudomonas fluorescens. Another embodiment of the invention includes secretion of the light chain and a fragment... Agent: Traskbritt, P.C.\dow Global Technologies Inc.
20090042255 - Method for recovering sperm nucleic acid from a forensic sample: A method for selectively recovering nucleic acid from a sperm cell in a sample containing cells of at least a sperm cell and an epithelial cell, and a cell suspension medium comprising extracellular impurities, is provided. The method entails introducing a sample into a vessel, sequestering the cells from the... Agent: Darby & Darby P.C.
20090042256 - Reactor plate and reaction processing method: Disclosed herein is a reactor plate including a sealed reaction well, a reaction well channel connected to the reaction well, and a reaction well air vent channel connected to the reaction well. The reaction well contains a reagent contained in the bottom thereof and a thermally fusible material which is... Agent: Cheng Law Group, PLLC
20090042257 - Adenoviral fiber exchange shuttle system: The instant invention provides methods and compositions for generating recombinant adenoviral vectors. The invention also provides kits comprising for the generation of recombinant adenoviral vectors.... Agent: Edwards Angell Palmer & Dodge LLP
20090042258 - Methods and compositions for dna manipulation: Methods and compositions are provided for generating a single-stranded extension on a polynucleotide molecule, the single-stranded extension having a desired length and sequence composition. Methods for forming single-stranded extensions include: the use of a cassette containing at least one nicking site and at least one restriction site at a predetermined... Agent: Harriet M. Strimpel, D. Phil.
20090042259 - Process for enzymatically converting a plant biomass: The present invention describes a process for at least a 90% conversion of a plant biomass preferably by a reduction of the units of cellulase needed and by using a xylanase which acts synergistically with the cellulase to improve the yield of xylose and glucose as sugars. The process enables... Agent: Ian C. Mcleod Ian C. Mcleod, P.C.
20090042261 - Process for the preparation of optically active 5-substituted 2-oxazolidinones from racemic epoxides and cyanate employing a halohydrin dehalogenase: A process for the production of an optically enriched oxazolidinone of the formula (2a) or (2b), by reacting an epoxide of the formula (1) with cyanate in the presence of halo-hydrin dehalogenase.... Agent: Connolly Bove Lodge & Hutz, LLP
20090042262 - Preparation of pregabalin and related compounds: Materials and Methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed.... Agent: Pfizer Inc.
20090042263 - Immobilized enzymes and methods of using thereof: The disclosed matter relates to immobilized enzymes and methods of use thereof.... Agent: Ballard Spahr Andrews & Ingersoll, LLP
20090042264 - Compositions and methods for manipulating carbon flux in cells: Nucleotide sequences and genetic constructs that can be used to regulate genes encoding enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as a R. oryzae cell, are provided. Methods of manipulating carbon flux in a cell also... Agent: K&l Gates LLP Henry W. Oliver Building
20090042265 - Thermophilic microorganisms with inactivated lactate dehydrogenase gene (ldh) for ethanol production: A mutated thermophilic microorganism is prepared, with a modification to inactivate the lactate dehydrogenase gene of a wild-type microorganism. The mutated microorganism is used in the production of ethanol, utilising C3, C5 or C6 sugars as the substrate.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090042266 - Treatment of cellulosic material and enzymes useful thererin: The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used e.g. for producing fermentable sugars for the production of bioethanol from lignocellulosic material. Cellulolytic enzymes and their production by recombinant technology is described, as well as uses of the enzymes and enzyme... Agent: Banner & Witcoff, Ltd.
20090042267 - Food waste treatment device using microorganisms: The present invention is directed to a composition for decomposing a majority of food waste into water and carbon dioxide comprising an effective combination of at least two species of microorganisms chosen from bacillus, lactobacillus, burkholderia, yeast fungus, eumycetes or any combinations thereof. A preferred embodiment comprises a combination of... Agent: Davidson, Davidson & Kappel, LLC
20090042268 - Iminosugar compounds with antiflavirus activity: wherein R2, R3, R4 and R5 are the same or different and are selected from the group consisting of hydrogen, acyl, benzyl, alkyl, aryl, sulfonyl, phosphonyl, silyl, R6 is at least one of alkyl or branched alkyl, heteroalkyl or aryl, R6′ is a bridging group selected from at least one... Agent: Woodcock Washburn LLP
20090042269 - Isolation of quiescin-sulfhydryl oxidase from milk: Methods for isolating a highly purified QSOX enzyme from milk or whey are described. The enzyme may be used to generate intermolecular and intramolecular disulfide bridges and to facilitate oxidative protein folding.... Agent: Ratnerprestia
20090042270 - Activatable recombinant neurotoxins: Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.... Agent: Allergan, Inc.
20090042271 - Esters of long-chain alcohols and preparation thereof: m
20090042272 - Processing of peptides and proteins: The invention provides novel methionine aminopeptidase enzymes and their use.... Agent: Novo Nordisk, Inc. Intellectual Property Department
20090042273 - Recovery of virus from cell culture using hypertonic salt solution: A process of harvesting a herpesvirus from a cell culture infected therewith comprises treating said culture with a hypertonic aqueous salt solution to yield a virus suspension, e.g. to give improved yield of virus for live virus vaccine where otherwise cell-disruption might be used to harvest the virus by disrupting... Agent: Klarquist Sparkman, LLP
20090042274 - Method of purifying virus envelope: An industrial purification method of a virus (e.g., Hemagglutinating Virus of Japan, HVJ) envelope is provided. To be specific, a method of purifying an inactivated virus envelope at a high recovery rate by ion exchange chromatography and hydrophobic chromatography, while maintaining the cell fusion activity of the virus, is provided.... Agent: Fitch, Even, Tabin & Flannery
20090042275 - Novel plasmids and utilization thereof: A shuttle vector is constructed by preparing a DNA region replicable in bacteria belonging to the genus Rhodococcus from a Rhodococcus-derived plasmid having the nucleotide sequence set forth as SEQ ID NO: 73 and a plasmid or its DNA fragment having the nucleotide sequence set forth as SEQ ID NO:... Agent: Osha Liang L.L.P.
20090042276 - Use of hop acids in fuel ethanol production: Six hop acids are common to hops and beer: alpha acid, beta acids, isoalpha acids, rho-isoalpha acids, tetrahydro-isoalpha acids, and hexahydro-isoalpha acids. The six hop acids were tested to determine which were the most effective in inhibiting the growth of bacteria common to fuel ethanol production. The bacteria used in... Agent: Edwards Angell Palmer & Dodge LLP
20090042278 - Method of protein production in yeast: Vectors, host cells, and methods are provided for the production of proteins in yeast. The vectors generally contain a selection gene, a yeast 2 micron sequence, and a polynucleotide encoding a polypeptide, where the polynucleotide is operably linked to promoter, and where the polynucleotide contains one or more yeast-preferred codons.... Agent: Goodwin Procter LLP Attn: Patent Administrator
20090042277 - Nucleic acids encoding recombinant soluble endoproteases: The present invention relates to the expression and secretion in Saccharomyces cerevisiae of readily purifiable soluble variants of the Kex1 endopeptidase of Kluyveromyces lactis and the purification and use thereof for the in vitro processing of recombinant proteins usable in industrial applications. The soluble Kex1 endoproteases described here are free... Agent: Darby & Darby P.C.
20090042279 - Method of detecting mild impaired glucose tolerance or insulin secretory defect: It is intended to provide a noninvasive method of conveniently detecting mild impaired glucose tolerance and/or insulin hyposecretion at the early stage with the use of an enzyme. Namely, mild impaired glucose tolerance and/or insulin hyposecretion at the early stage are detected by quantifying myoinositol secreted into the urine before... Agent: Birch Stewart Kolasch & Birch
20090042281 - Compound profiling devices, systems, and related methods: High throughput compound profiling systems, and related devices and sub-systems that can be used to perform various compound profiling processes are provided. These systems typically include work perimeters that are organized for optimum efficiency and processing accuracy. Further, these systems are readily adaptable for performing a wide array of assays,... Agent: Genomics Institute Of The Novartis Research Foundation
20090042280 - Fluidic cartridges for electrochemical detection of dna: A flow cell cartridge for the detection of differences in nucleic acid sequences is disclosed. The flow cell cartridge has an electrode array and two openings, in which one opening is for the entry and exit of sample, and the other opening is for the control of the entry and... Agent: Knobbe Martens Olson & Bear LLP
20090042282 - Preparation of protective antigen: f
20090042284 - Method for labeling/separation of cells and agent for labeling/separation of cells: Disclosed are a cell labeling/separation method and a cell labeling/separation agent capable of identifying a target cell in a simplified manner while achieving a significantly high degree of accuracy in cell separation. The method comprises adding a micro- or nano-capsule 1 encapsulating gas 2, into a solution containing a target... Agent: Jordan And Hamburg LLP
20090042283 - Optimized messenger rna: The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common... Agent: Lowrie, Lando & Anastasi, LLP
20090042285 - Antibodies at t cell receptor mimics, methods of production and uses thereof: The present invention relates to a methodology of producing antibodies that recognize peptides associated with a tumorigenic or disease state, wherein the peptides are displayed in the context of HLA molecules. These antibodies will mimic the specificity of a T cell receptor (TCR) but will have higher binding affinity such... Agent: Dunlap Codding, P.C.
20090042287 - Pdx1 expressing endoderm: Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of... Agent: Knobbe Martens Olson & Bear LLP
20090042286 - Use of the aca glycoprotein for obtaining/maintaining pluripotent non-embryonic stem cells: Described is the use of a glycosylphosphatidylinositol (GPI)-anchored glycoprotein ACA or activator of ACA for obtaining pluripotent non-embryonic stem cells or for maintaining the pluripotenial phenotype of non-embryonic stem cells.... Agent: Klauber & Jackson
20090042288 - Method of producing organotypic cell cultures: The present invention relates to cell and tissue culture. In particular, the present invention provides a method for preparing an organotypic culture using dissociated cells or microexplants obtained from an animal organ. The method for preparing an organotypic culture comprises culturing cells from an organ on a surface characterised in... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP
20090042289 - Preservation of cells: The present invention relates to methods for preserving cells, in particular primary cells such as hepatocytes. In particular, the present invention relates to preserving cells within a gel comprising a hydrolysed gelatin and culturing the cells at a temperature between 0 and 15° C.... Agent: Banner & Witcoff, Ltd.
20090042292 - B7-dc variants: Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector functions of T cells and/or promoting T cell survival) are provided. Suitable compositions include variant B7-DC polypeptides, fragments and fusion proteins thereof. Variant B7-DC polypeptides have... Agent: Patrea L. Pabst Pabst Patent Group LLP
20090042290 - Method of modifying a macromolecule without prior extraction from a sample: The present invention encompasses a method of modifying a macromolecule without prior extraction from a sample by converting the macromolecule in the sample with a chemical, removing or converting chemical intermediates, if necessary; and purifying the resulting modified macromolecule.... Agent: Philip S. Johnson Johnson & Johnson
20090042291 - Optimized fc variants: The present invention relates to optimized Fc variants, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.... Agent: Dorsey & Whitney, LLP Intellectual Property Department
20090042293 - Cell culture apparatus, cell culture method, cell culture program and cell culture system: The invention intends to provide a cell culture apparatus which is able to realize an adequate culture according to the culture state of cells while alleviating the labor of an operator. The cell culture apparatus includes a culture bag for causing the cells to proliferate, a cell inoculation cassette (or... Agent: Frishauf, Holtz, Goodman & Chick, PC
20090042294 - Hydroxyphenyl cross-linked macromolecular network and applications thereof: A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic macromolecular network for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are... Agent: Pearne & Gordon LLP
20090042295 - Cell culture substrate and its production method: d
20090042298 - Compositions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells: Polynucleotide delivery-enhancing polypeptides are admixed or complexed with, or conjugated to, nucleic acids for enhancing delivery the nucleic acids into cells. The transported nucleic acids are active in target cells as small inhibitory nucleic acids (siNAs) that modulate expression of target genes, mediated at least in part by RNA interference... Agent: Nastech Pharmaceutical Company Inc Mdrna, Inc.
20090042297 - Piggybac transposon-based vectors and methods of nucleic acid integration: Disclosed herein are compositions comprising integrating enzymes that can deliver nucleic acids to a target DNA. Additionally, the methods of using the compositions disclosed herein relate to treatments for a variety of infections, conditions, and genetic disorders.... Agent: Ballard Spahr Andrews & Ingersoll, LLP
20090042296 - Transfection ready eukaryotic cells: Described herein are frozen populations of transfection ready competent eukaryotic cells, transfection kits comprising the frozen populations of transfection ready competent cells, and methods of using the same.... Agent: Knobbe Martens Olson & Bear LLP
20090042299 - Vectors and methods for tissue specific synthesis of proteins in eggs of transgenic hens: Vectors and methods are provided for introducing genetic material into cells of a chicken or other avian species. More particularly, vectors and methods are provided for transferring a transgene to an embryonic chicken cell, so as to create a transgenic hen wherein the transgene is expressed in the hen's oviduct... Agent: Wilmerhale/boston
20090042300 - Method for enhancing gene expression in plants: The invention relates to the field of gene expression in plants and describes methods and constructs using the first intron of a FAD2 gene in order to enhance gene expression.... Agent: Connolly Bove Lodge & Hutz, LLP
20090042302 - Isolated polynucleotides and methods of promoting a morphology in a fungus: The invention includes isolated polynucleotide molecules that are differentially expressed in a native fungus exhibiting a first morphology relative to the native fungus exhibiting a second morphology. The invention includes a method of enhancing a bioprocess utilizing a fungus. A transformed fungus is produced by transforming a fungus with a... Agent: Wells St. John P.s.
20090042301 - Temperature regulated gene expression: A method for regulation of gene expression by variation of temperature uses a riboswitch. The riboswitch includes a 5′-UTR construct of crhC which alters its secondary structure in response to temperature, resulting in a more stable transcript at lower temperatures, permitting translation. At higher temperatures, the transcript is destabilized and... Agent: Edward Yoo C/o Bennett Jones02/05/2009 > patent applications in patent subcategories. patent applications/inventions, industry category
20090035744 - Apparatus and method for separating and storing human reproductive material in a cryotank: Apparatus and method for separating individual human reproductive material from a fertilization dish and storing the material in a cryotank for future fertilization and implantation. The apparatus includes an elongate cryostraw having a first open end and second heat-sealable open end, a channel extending between said ends, and an internal,... Agent: Joseph M. Konieczny, P.C.
20090035743 - Assay system: The present invention provides an agglutination based assay system for determining the presence and/or amount of analyte in a sample comprising a test device having one or more capillary pathways comprising detection regions adapted for non-visual detection of a sample which is releasably engageable with a reader which comprises detection... Agent: Speckman Law Group PLLC
20090035745 - Site-specific dosing of cellular cultures: Systems and methods for site-specific dosing of cellular cultures are provided. Some of the systems provided comprise at least two laminar flow channels; and an ablatable membrane that is disposed between the at least two laminar flow channels. Other systems provided comprise at least two laminar flow channels; and an... Agent: Baker Botts, LLP
20090035746 - Device and method for preparing a sample for an analysis and device and method for analyzing a sample: A device and method are disclosed for preparing a sample for an analysis and a device and method are disclosed for analyzing a sample. In at least one embodiment, a device is disclosed for preparing a sample for analysis including means for binding at lest one biological structure of the... Agent: Harness, Dickey & Pierce, P.L.C
20090035748 - Bromelain as a clinical sample pre-treatment, lysis agent and nuclease inhibitor: This invention generally relates to the use of the proteolytic enzyme bromelain for treating samples for diagnostic assays. More specifically, the present invention relates to the use of bromelain in methods for pre-treating clinical samples primarily for the purpose of obtaining extractable and amplifiable DNA or RNA from prokaryotic or... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company
20090035750 - Method of detecting human papilloma virus by using nucleic acid amplification method and nucleic acid chain-immobilized carrier: Provided is a nucleic acid primer for LAMP amplification for use in the detection of human papilloma virus and identification of its genotype. The present invention also provides a method of detecting human papilloma virus and identifying its genotype, includes a step of amplifying the nucleic acid chains in a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090035747 - Nucleic acid and gene derived from novel hcv strain and replicon-replicating cell using said gene: The present invention relates to a gene derived from a novel fulminant hepatitis C virus strain, an HCV replicon RNA with a high replication efficiency obtained using the gene, and an HCV replicon-replicating cell transfected with the replicon RNA. When the HCV replicon RNA and the HCV replicon-replicating cell of... Agent: Birch Stewart Kolasch & Birch
20090035762 - Allele-specific copy number measurement using single nucleotide polymorphism and dna arrays: Methods and systems for allelic detection and allele-specific copy number are provided herein. The described methods use identification of single nucleotide polymorphism using restriction enzymes and CGH analyses. Microarrays comprising probes designed by the described methods are provided. Also included are methods for identifying SNP sites and copy number in... Agent: Agilent Technologies Inc.
20090035782 - Breeding plants: A process for breeding plants which comprises growing plants of a species in an array of containers charged with growing medium of uniform characteristics in an environment of controlled climatic conditions with controlled supply of nutrients and feed water and changing the positions of the containers within the environment as... Agent: Connolly Bove Lodge & Hutz, LLP
20090035760 - Caldag-gef1 gene mutations associated with thrombopathy: The present invention relates to methods and compositions for detecting mutations associated with thrombopathy. In particular, the invention relates to methods and composition for detecting mutations in the CalDAG-GEF1 gene that are associated with thrombopathy.... Agent: Andrus, Sceales, Starke & Sawall, LLP
20090035780 - Detection of methicillin-resistant and methicillin-sensitive staphylococcus aureus in biological samples: Disclosed are methods of identifying a methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-sensitive Staphylococcus aureus (MSSA) in a sample. The present invention provides a diagnostic method comprising modification of sequences of S. aureus by converting non-methylated cytosine residues ultimately into thymidine residues in the target nucleic acid. The invention further provides... Agent: Foley & Lardner LLP
20090035769 - Genetic markers associated with scoliosis and uses thereof: The present invention relates to novel genetic markers associated with scoliosis, risk of developing scoliosis and risk of scoliosis curve progression, and methods and materials for determining whether a human subject has scoliosis, is at risk of developing scoliosis or is at risk of scoliosis curve progression.... Agent: Michael R. Schramm Axial Biotech, Inc.
20090035772 - Genetic markers associated with scoliosis and uses thereof: The present invention relates to novel genetic markers associated with scoliosis, risk of developing scoliosis and risk of scoliosis curve progression, and methods and materials for determining whether a human subject has scoliosis, is at risk of developing scoliosis or is at risk of scoliosis curve progression.... Agent: Michael R. Schramm Axial Biotech, Inc.
20090035771 - Hepatocellular carcinoma-related genes and polypeptides, and method for detecting hepatocellular carcinomas: Genes up-regulated in hepatocellular carcinomas and polypeptides encoded by these genes are provided. Vectors, transformants and methods for producing the recombinant polypeptides are also provided. Probes and primers of these genes and antibodies against the polypeptides are also provided. The probes, primers and antibodies can be used as reagents for... Agent: Ingrid A. Beattie Mintz, Levin, Cohn, Ferris,
20090035777 - High throughput nucleic acid sequencing by expansion: Nucleic acid sequencing methods and related products are disclosed. Methods for sequencing a target nucleic acid comprise providing a daughter strand produced by a template-directed synthesis, the daughter strand comprising a plurality of subunits coupled in a sequence corresponding to a contiguous nucleotide sequence of all or a portion of... Agent: Seed Intellectual Property Law Group PLLC
20090035770 - Inline-injection microdevice and microfabricated integrated dna analysis system using same: Methods and microfluidic circuitry for inline injection of nucleic acids for capillary electrophoresis analysis are provided. According to various embodiments, microfabricated structures including affinity-based capture matrixes inline with separation channels are provided. The affinity-based capture matrixes provide inline sample plug formation and injection into a capillary electrophoresis channel. Also provided... Agent: Weaver Austin Villeneuve & Sampson LLP
20090035759 - Method and device for detecting the presence of a single target nucleic acid in a sample: A method comprises loading a sample portion into a sample chamber which comprises means for minimizing diffusion of the sample portion, subjecting the sample portion to an amplification step, and determining whether the sample portion contains at least one molecule of a target nucleic acid. If the sample portion contains... Agent: Burr & Brown
20090035776 - Method and kit for hla-b genotyping based on real-time pcr: Method and kit based on real-time PCR with specific primers and probes that allow to achieve a high degree of subtyping of the complete HLA-B locus. The main advantages are the greater speed (65 minutes, including the interpretation); the ease of automation, since only eighteen tubes are necessary to obtain... Agent: Berenbaum, Weinshienk & Eason, P.c
20090035774 - Method for characterizing primary tumors: The invention relates to a method for the detection and characterisation of primary tumours and separate areas of primary tumours, respectively. Clusters of tumour cells, extracted from sample material, are isolated and concentrated, followed by an analysis of genetic changes in these isolated cell clusters.... Agent: Leydig Voit & Mayer, Ltd
20090035761 - Method for isolation of dna, rna and proteins from formalin-fixed paraffin-embedded tissue specimens: Methods are disclosed for rapid, reliable and simple isolation of RNA from formalin-fixed paraffin-embedded tissue samples. RNA purified in this manner can be used to monitor gene expression levels. The tissue sample can be a tumor or other pathological tissue.... Agent: Berliner & Associates
20090035768 - Method of determining predisposition to scoliosis and uses thereof: The present invention relates to novel genetic markers associated with scoliosis, risk of developing scoliosis and risk of scoliosis curve progression, and methods and materials for determining whether a human subject has scoliosis, is at risk of developing scoliosis or is at risk of scoliosis curve progression.... Agent: Michael R. Schramm Axial Biotech, Inc.
20090035758 - Method of measurement of micronucleated erythrocyte populations: A method of measuring micronucleated erythrocyte populations is disclosed. The method includes contacting a sample containing erythrocyte populations with a fluorescently labeled antibody specific to immature erythrocytes among erythrocyte populations; adding an aqueous permeation reagent to the sample and incubating the formed permeation sample mixture for an incubation time sufficient... Agent: Beckman Coulter, Inc. Mitchell E. Alter
20090035778 - Methods and compositions for correlating genetic markers with multiple sclerosis: The present invention provides, in certain aspects, a method of identifying a subject as having an increased risk of developing multiple sclerosis, comprising detecting in the subject the presence of a nucleotide variant in the interleukin 7 receptor alpha chain gene, whereby the presence of said variant identifies the subject... Agent: Myers Bigel Sibley & Sajovec
20090035754 - Methods and compositions for detecting steroids: The present invention provides for methods and systems for detecting steroids. Examples of such steroids include estrogen, progesterone, androgen, testosterone, and derivatives and analogs thereof. Systems useful for carrying out the method include tripartite constructs including a DNA-binding domain, a ligand binding domain, and an activation domain. The present invention... Agent: The Mccallum Law Firm, P. C.
20090035781 - Methods and compositions for identifying a subject with an increased risk of gram negative bacterial infection: The present invention provides method of identifying a subject as having an increased risk of developing a Gram negative bacterial infection and/or as having an increased risk of mortality, comprising genotyping the subject for the presence of particular alleles of the lipopolysaccharide binding protein gene, wherein the presence of said... Agent: Myers Bigel Sibley & Sajovec
20090035764 - Methods and systems for evaluating cgh candidate probe nucleic acid sequences: Methods of evaluating candidate CGH probe nucleic acid sequences are provided. Aspects of the methods include providing a candidate CGH probe nucleic acid sequence for a target sequence of a copy number variation (CNV) of a genome. A proximity score is then determined for the candidate CGH probe nucleic acid... Agent: Agilent Technologies Inc.
20090035766 - Methods for analyzing high dimension data for classifying, diagnosing, prognosticating, and/or predicting diseases and other biological states: A method of diagnosing, predicting, or prognosticating about a disease that includes obtaining experimental data, wherein the experimental data is high dimensional data, filtering the data, reducing the dimensionality of the data through use of one or more methods, training a supervised pattern recognition method, ranking individual data points from... Agent: National Institutes Of Health
20090035756 - Methods for arbitrary peptide synthesis: Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.... Agent: Searete LLC Clarence T. Tegreene
20090035763 - Methods for detecting progression of low grade cervical dysplasia and for detecting adenocarcinomas: The invention provides methods for identifying conditions of low grade cervical dysplasia and assessing the progressive potential of individual lesions to develop into high grade cervical dysplasia and cervical squamous cell cancer as well as cervical adenocarcinoma.... Agent: Edwards Angell Palmer & Dodge LLP
20090035773 - Nucleic acid sequences for detecting genetic markers for cancer in a biological sample: Nucleic acid sequences for detecting the presence of nucleic acids, particularly mRNA, encoding human prostate-associated genetic markers encoding prostate-specific antigen (PSA), prostate specific membrane antigen (PSMA) or human kallikrein 2 (hK2) are disclosed. Preferred combinations of nucleic acid sequences amplifying and detecting the prostate-associated genetic markers RNA, used in methods... Agent: Gen Probe Incorporated
20090035775 - Pcr-based detection method for chlamydia treachomatis: A process for designing of PCR-based detection method for Chlamydia trachomatis comprising designing of PCR primers from the genome sequence of Chlamydia trachomatis selecting DNA sequence of genes for PCR based diagnostic of Chlamydia trachomatis, optimizing the PCR conditions of the PCR primers; subjecting the said genes and primers to... Agent: The Webb Law Firm, P.C.
20090035752 - Polynucleotide participating in rheumatoid arthritis and utilization of the same: Analysis is made on the DNA methylation of the region (including a promoter region) upstream from the translation initiation point of a rheumatoid arthritis-associated gene DR3 in human genome. As a result, it is found out that an allele-specific methylation occurs in a CpG sequence located about −380 to −180... Agent: Nixon & Vanderhye, PC
20090035765 - Polynucleotides and methods for making plants resistant to fungal pathogens: This invention relates to polynucleotide sequences encoding a gene that can confer resistance to the plant pathogen Colletotrichum, which causes anthracnose stalk rot, leaf blight and top dieback in corn and other cereals. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which... Agent: Pioneer Hi-bred International, Inc.
20090035767 - Primer for bacterium genome amplification reaction: i
20090035751 - Single molecule detection using molecular motors: The present invention provides methods and compositions for highly sensitive nucleic acid detection, down to the single nucleic acid molecule level. In one aspect, the present invention provides methods for detecting a target nucleic acid comprising: (a) providing first and second target-specific nucleic acids, wherein the first and second target-specific... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090035757 - Substractive single label comparative hybridization: Provided are methods of determining differences between nucleic acids in a test sample and a reference sample. In certain embodiments the methods are used for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale... Agent: Foley & Lardner LLP
20090035779 - Systems and methods for determining cross-talk coefficients in pcr and other data sets: Systems and methods for determining cross-talk coefficients in curves, such as sigmoid-type or growth curves, and PCR curves and nucleic acid melting curves in particular, as well as for applying the cross-talk coefficients to produce cross-talk corrected data sets using a linear subtractive model. Cross-talk signal coefficients are determined using... Agent: Townsend And Townsend And Crew, LLP
20090035755 - Yeast strain and screening method for identifying inhibitors of the expression of the hexose transporter genes by a positive phenotype: The present invention provides screening procedures for identifying inhibitors of components of regulatory networks by a positive phenotype and modified yeast cell lines suitable for said screening. The screening procedures are especially suited to screen for substances that re-sensitize resistant pathogenic microorganisms or tumor cells by suspending the expression of... Agent: Ballard Spahr Andrews & Ingersoll, LLP
20090035787 - Enzymatic synthesis of sulfated polysaccharides without iduronic acid residues: Iduronic acid (IdoUA)-free heparan sulfate (HS)-like compounds are provided. Also provided are methods of synthesizing IdoUA-free HS-like compounds. The methods can include providing at least one O-sulfotransferase (OST) enzyme and a reaction mixture comprising 3′-phosphoadenosine 5′-phosphosulfate (PAPS); and incubating a polysaccharide substrate with the at least one OST and the... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20090035783 - Fluorescent proteins and uses thereof: A fluorescent sensor and methods for producing and using the fluorescent sensor. Such fluorescent sensors have broad applicability in characterizing cells and organisms, in detecting or measuring various cellular parameters, and in detecting or measuring protein-protein/peptide interactions.... Agent: Christopher B. Linder Thomas, Kayden, Horstemeyer & Risley, L.L.P.
20090035785 - Immunoassay method and reagent therefor: The present invention provides a novel immunoassay method with high reaction specificity and high sensitivity. The present invention also provides a method for immunoassaying a target antigen utilizing reactivation of an apoenzyme, which includes simultaneously or sequentially adding a test sample to an antibody specific to the target antigen, the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090035786 - Multi-analyte affinity column: A multi-analyte column is disclosed. The column may contain at least one unit of resin having ochratoxin specific affinity and, for each unit of resin having ochratoxin specific affinity, the column further contains about 0.95 to 1.05 units of resin containing antibody having specificity for zearalenone, about 1.9 to 2.1... Agent: Edwards Angell Palmer & Dodge LLP
20090035784 - Npc1l1 and npc1l1 inhibitors and methods of use thereof: The present invention provides a novel gene, designated herein as “NPC1L1”, that is associated with lipid or glucose metabolism. The invention further provides the use of the NPC1L1 gene and its corresponding protein to diagnose a lipid condition in a cell or tissue and to screen for novel therapeutic compounds... Agent: Darby & Darby P.C.
20090035788 - Genetically encoded bioindicators of calcium-ions: The present invention relates to novel types of cellular calcium probes that are based on Troponin C and two chromophors suitable for FRET (fluorescence resonance energy transfer). The Troponin C-based calcium sensors of the invention function in diverse subcellular environments, for example even when tethered to a cellular membrane. The... Agent: Foley And Lardner LLP Suite 500
20090035791 - Neural colony forming assay: A neural colony forming cell (NCFC) assay is described. The assay allows one to distinguish neural stem cells from neural progenitor cells. In one embodiment, the present invention provides a method for identifying neural stem cells or neural progenitor cells comprising: (a) suspending neural cells in a semi-solid medium which... Agent: Dann, Dorfman, Herrell & Skillman
20090035792 - Drug selection for lung cancer therapy using antibody-based arrays: The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of... Agent: Townsend And Townsend And Crew, LLP
20090035789 - Monitoring enzyme mixtures: This invention provides a method for simultaneously detecting the presence of at least two enzymes in a sample, said method comprising the steps of; i) providing a first substrate for a first enzyme, said first substrate being labeled with a first fluorophore, ii) providing a second substrate for a second... Agent: Quarles & Brady LLP
20090035790 - High sensitivity immunoassays and kits for the determination of peptides and proteins of biological interest: The invention relates to immunoassays which allow the detection of polypeptides in samples with a higher sensitivity than assays of the state of the art. The invention also relates to kits which provide the components needed for carrying out said immunoassays.... Agent: Moore & Van Allen PLLC
20090035794 - Method for detecting, screening, and/or monitoring cancer in an individual: The invention relates to a method for screening and/or detecting and/or monitoring a cancer in an individual, said method comprising determining a first parameter represented by the concentration of TIMP-1 in at least one excreta, e.g. saliva, from the individual. The invention provides a method that without the need to... Agent: Roberts Mlotkowski Safran & Cole, P.C. Intellectual Property Department
20090035793 - Microchip for cell response evaluation: In a microchip which enables cell cultivation and accurate cell count measurement, fine particles affixed with cells are trapped within a passage by making the minimum width of a solution and fine particle inlet into a cell culture portion larger than the maximum diameter of the fine particles, and making... Agent: Oliff & Berridge, PLC
20090035795 - Method and composition for forming a uniform layer on a substrate: A method of reducing thickness non-uniformity in a microjet-deposited solids layer is disclosed which comprises depositing onto a substrate by microjet deposition a composition containing a liquid vehicle, at least one reagent; and a polyol which is present at a concentration that enhances thickness uniformity of a solids layer, containing... Agent: Hewlett Packard Company
20090035796 - Enzyme sensors including environmentally sensitive or fluorescent labels and uses thereof: Sensors for detecting enzyme activity are provided. The sensors include substrate modules having environmentally sensitive labels and detection modules whose binding to the substrate modules results in changes in signals from the environmentally sensitive labels or polypeptides or polypeptide substrates including environmentally sensitive or fluorescent labels. Compositions including substrate modules,... Agent: Quine Intellectual Property Law Group, P.C.
20090035797 - Detection of disease associated proteolysis: Described herein are methods and techniques to study the “degradome”. The degradome of a specific protease is the complete product of the natural substrate repertoire of that enzyme in a cell, tissue or organism. The complete set of proteases that are expressed at a particular moment or circumstance by a... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP
20090035798 - Methods for reducing the immunogenicity of cytokines and removal of cell surface markers: The present invention provides means to assess the comparative allergenicity of proteases. In particular, the present invention provides means to qualitatively assess the potential for any protease to induce an allergic response in humans. In addition, the present invention provides means to select proteases with reduced allergenicity for use in... Agent: Kamrin T. Macknight Genencor International
20090035799 - Novel trypsin family serine proteases: Two novel trypsin-family serine proteases specifically expressed in adult mouse testis (“Tespec PRO-1” and “Tespec PRO-2”), and a novel trypsin-family serine protease derived from mouse (“Tespec PRO-3”) have been isolated. Also, two novel trypsin-family serine proteases derived from human (“Tespec PRO-2” and “Tespec PRO-3”) have been isolated. It has been... Agent: Clark & Elbing LLP
20090035800 - Novel use of fluorescence resonance energy transfer: A novel use of Fluorescence Resonance Energy Transfer wherein a labelled protein comprising a Fluorescent energy donor label and at least one energy acceptor moiety capable of accepting energy from the donor label by Förster energy transfer is exposed to incident electromagnetic energy to excite the donor moiety and the... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090035807 - Analysis of polypeptide production: The present invention is directed to methods of evaluating a process to produce a polypeptide preparation or evaluating an element of a process to produce a polypeptide preparation. The methods comprise providing a sample comprising the polypeptide, wherein the sample has not been subjected to affinity chromatography, and subjecting the... Agent: Wyeth Patent Law Group
20090035805 - C3a serum-free clonal cell line and methods of use: A serum-free C3A clonal cell line and methods for generating the same are provided. The C3A cell line has a reduced doubling time in serum-free medium compared to a corresponding C3A cell line from which it is derived. Methods using the cells of the serum-free C3A clonal cell line for... Agent: Dla Piper LLP (us)
20090035804 - Constitutively open herg (kv11.1) mutant channels: We disclose a cell having double mutations of the HERG gene that lead to charge reversal amino acid substitutions at residues 466 and 534 of the wild type Kv11.1 channel protein. These double charge reversal mutations result in cells having constitutively open Kv11.1 channels. Such cells could be used in... Agent: Quarles & Brady LLP
20090035802 - Method for detection and enumeration of cell surface markers: Disclosed is a method for detecting and counting cell surface markers using a difference in fluorescence intensities. A fluorescent material having a relatively lower fluorescence intensity is conjugated with one marker and another fluorescent material having a relatively higher fluorescence intensity is conjugated with the other marker. The two markers... Agent: Edwards Angell Palmer & Dodge LLP
20090035806 - Method for identification of age of an ancient ware by using microbes: This invention is related to a method for identification of age of the ancient wares, particularly a method for identification of age of the ancient wares by using the microbe. The method of this invention includes the following steps: establish database corresponding to the microbe parameters in wares to be... Agent: GlobalIPServices
20090035803 - Method for stabilization of peptides in a biological sample: The present invention provides a simple method for the stabilization of a peptide in a biological sample and a reagent for the stabilization, a simple method for the preservation of a biological sample comprising a peptide and a reagent for the preservation, and a method for the accurate measurement of... Agent: Fitzpatrick Cella Harper & Scinto
20090035801 - Twelve (12) protein biomarkers for diagnosis and early detection of breast cancer: The invention relates to 12 identified protein biomarkers for diagnosis, determination of disease severity, and therapeutic response monitoring of patients with breast cancer. The method is based on the use of 2-dimensional (2D) gel electrophoresis to separate the complex mixture of proteins found in blood serum, the quantitation of up... Agent: Power3 Medical Products, Inc. Steven B. Rash
20090035808 - Medium for detecting microorganisms: Provided is a culture medium for microorganisms present in contaminated working fluids such as coolants. More particularly, said culture medium is particularly suitable for supporting growth of microorganisms colonizing metalworking fluids and allows for specific detection of both bacterial microorganisms and fungal microorganisms the latter depending on the added selective... Agent: Tarolli, Sundheim, Covell & Tummino L.L.P.
20090035809 - Modified carbocyanine dyes and their conjugates: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein... Agent: Invitrogen Corporation C/o Intellevate
20090035810 - Modified carbocyanine dyes and their conjugates: Chemically reactive carbocyanine dyes incorporating an indolium ring moiety that is substituted at the 3-position by a reactive group or by a conjugated substance, and their uses, are described. Conjugation through this position results in spectral properties that are uniformly superior to those of conjugates of spectrally similar dyes wherein... Agent: Invitrogen Corporation C/o Intellevate
20090035811 - Artificial scaffolding material for protein retention and use of the same: The present invention provides an artificial scaffolding material for retaining proteins suitable for placing contiguously one species or two or more species of proteins such as enzymes. To this end, the artificial scaffolding material for retaining proteins is provided with a cell and scaffolding proteins heterologous to the cell and... Agent: Oliff & Berridge, PLC
20090035812 - Microbial hydrogen-producing process and system thereof: The present invention provides a microbial hydrogen-producing process, comprising: providing at least one Clostridium microbe and at least one Bacillus microbe; and co-culturing said at least one Clostridium microbe and said at least one Bacillus microbe in a fermentation culture system to produce hydrogen. The present invention also provides a... Agent: Bacon & Thomas, PLLC
20090035814 - Method for producing circular or multimeric protein species in vivo or in vitro and related methods: A method is disclosed for forming multimeric proteins. The method relies on intermolecular trans-splicing of a split intein either in vivo or in vitro.... Agent: Harriet M. Strimpel, D. Phil.
20090035813 - Oligosaccharide mixture: An oligosaccharide mixture derived from animal milk, food products comprising said oligosaccharide mixture and a process for producing said oligosaccharide mixture.... Agent: Bell, Boyd & Lloyd LLP
20090035816 - Process for the preparation of a polypeptide: A process for the preparation of a polypeptide made from amino acids L-alanine, L-glutamic acid, L-lysine, and L-tyrosine comprising using N-thiocarboxyanhydride of at least one amino acid as a starting material.... Agent: Cohen, Pontani, Lieberman & Pavane LLP
20090035815 - Synthetic gene for enhanced expression in e. coli: A novel nesiritide synthetic cDNA chimera encoding human b-type natriuretic peptide (hBNP) or nesiritide and a process for the preparation of the said novel chimera. Further, the inventors disclose the use of nesiritide synthetic cDNA chimera to obtain an expressible construct to produce mature nesiritide. Particularly, the inventors disclose an... Agent: Pharmaceutical Patent Attorneys, LLC
20090035819 - Ca125 gene and its use for diagnostic and therapeutic interventions: The CA125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The CA125 molecule comprises three major domains: an extracellular amino terminal domain (Domain 1); a large multiple repeat domain (Domain 2); and a carboxy terminal domain (Domain 3) which includes a... Agent: Hugh Mctavish Mctavish Patent Firm
20090035821 - Expression of proteins in e.coli: Plasmid comprising a DNA tag encoding a peptide tag of the sequence MX1(X2X3)n wherein X1 represents K, R or H; X2 represents A, G, H, M, S or T; X3 represents K, R, H, A, Q or V; n represents an integer of 1 or larger; and wherein said DNA... Agent: Novo Nordisk, Inc. Intellectual Property Department
20090035817 - Method for preparing transformants expressing benzaldehyde dehydrogenase and preparation of 2,6-naphthalene dicarboxylic acid using the transformants: Disclosed herein are a method for preparing a transformant which carries a gene encoding benzaldehyde dehydrogenase derived from Sphingomonas aromaticivorans KCTC 2888 and expresses the enzyme, and biological purification of the crude naphthalene dicarboxylic acid, obtained upon the oxidation of 2,6-dimethylnaphthalene with the concomitant production of 2-formyl-6-naphthoic acid, by applying... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090035820 - Microbial trypsin mutants having chymotrypsin activity and nucleic acids encoding same: The present invention relates to microbial trypsin variants having chymotrypsin-like activity, comprising: (a) a one or more substitutions corresponding to positions 144, S193A, 198, 201, 218, 223, 227, 228, 229, 230, and 231 of amino acids 25 to 248 of SEQ ID NO: 2, (b) one or more deletions corresponding... Agent: Novozymes, Inc.
20090035818 - Novel polypeptide, polynucleotide encoding the polypeptide and use the polypeptide and polynucleotide: In one embodiment of the present application, a polypeptide capable of binding to a sugar chain is disclosed, particularly a high-mannose-type sugar chain bound to an antibody, more preferably a sugar chain bound to a chicken antibody. Also disclosed is a method for the purification of an antibody (specifically a... Agent: Harness, Dickey & Pierce, P.L.C
20090035822 - Fusion proteins: A single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a nociceptive sensory afferent; a Targeting Moiety that is capable of binding to a Binding Site on the nociceptive... Agent: Merchant & Gould - Syntaxin
20090035825 - Devices, systems, and methods for preparing emulsions: A vortex mixer and method for forming an emulsion wherein the mixer is adapted to form an emulsion with a desired droplet size and having a desired volume. The vortex mixer provides improved uniformity in emulsion preparation and may be used to create multiple emulsions simultaneously.... Agent: Mila Kasan, Patent Dept. Applied Biosystems
20090035823 - Ligation-based synthesis of oligonucleotides with block structure: The present invention relates to a method of producing single-stranded nucleic acid molecules from oligo- or polynucleotides wherein each of said oligo- or polynucleotides has a predefined 5′ or 3′ terminus, comprising the steps of (a) annealing an adaptor oligonucleotide simultaneously or step by step to (aa) a first oligo-... Agent: Knobbe Martens Olson & Bear LLP
20090035824 - Nucleic acid-templated chemistry in organic solvents: The present invention provides methods and compositions for performing nucleic acid mediated chemistry in a variety of organic solvents. A variety of nucleic acid mediated chemical reactions may be efficiently carried out in organic solvents.... Agent: Goodwin Procter LLP Patent Administrator
20090035826 - Method for the production of alcohol from a pretreated lignocellulosic feedstock: A process for the production of glucose from a pretreated lignocellulosic feedstock is provided. The method comprises enzymatically hydrolyzing the pretreated lignocellulosic feedstock with cellulase enzymes to produce a hydrolyzate slurry comprising glucose and unhydrolyzed cellulose and fermenting the hydrolyzate slurry in a fermentation reaction to produce a fermentation broth... Agent: Fitzpatrick Cella Harper & Scinto
20090035749 - Analysis of hiv-1 coreceptor use in the clinical care of hiv-1 infected patients: A change in viral tropism occurs in many HIV positive individuals over time and can be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations... Agent: Frommer Lawrence & Haug
20090035753 - Novel druggable regions in the dengue virus envelope glycoprotein and methods of using the same: The present invention relates to novel druggable regions discovered in dengue virus envelope glycoprotein, or dengue virus E protein, which is a class II viral E protein. The present invention further relates to methods of using the druggable regions to screen potential candidate therapeutics for diseases caused by viruses having... Agent: Foley Hoag LLP Patent Group
20090035827 - O-acetyltransferase from neisseria meningitidis, compositions and methods: Provided are recombinant DNA molecules that do not occur in nature encoding a Lot3 O-acetyltransferase, vectors that direct expression of a Lot O-acetyltransferase, recombinant host cells which express a Lot3 O-acetyltransferase, methods for recombinant production of a Lot3 O-acetyltransferase, methods for acetylating lipooligosaccharides, especially those of a Neisseria meningitidis using... Agent: Greenlee Winner And Sullivan P C
20090035828 - Method for the preparation of cross linked protein crystals: A protein such as an enzyme is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent. The crosslinked protein crystals may be lyophilized for storage. A preferred protein is an enzyme such as amyloglucosidase, Horse radish peroxidase, plant peroxidases etc. Crosslinked enzyme crystals preferably retain at least... Agent: Luedeka, Neely & Graham, P.C.
20090035829 - Enzymatic process for the preparation of paliperidone and its intermediate cmhtp: The present invention provides a process for the preparation of a 4H-pyrrido[1,2-a]-pyrimidin-4-one derivative, wherein the 4H-pyrrido[1,2-a]-pyrimidin-4-one derivative is Paliperidone or 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one (‘CMHTP’), said process comprising enzymatically hydroxylating Risperidone or 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one (‘ClMTTP’), respectively, with at least one oxidoreductase enzyme; and optionally isolating or purifying the Paliperidone or CMHTP, wherein the at... Agent: Kenyon & Kenyon LLP
20090035830 - Method for preparing optically active amines: The present invention relates to a method of preparing optically active amines and chiral amines prepared thereby. The method includes reacting an amine compound, a metal catalyst, a biocatalyst including a lipase, and an acyl donor compound in an organic solvent to obtain a chiral amide compound, and then hydrolyzing... Agent: Marshall, Gerstein & Borun LLP
20090035831 - Enantioselective immobilized lipase: Immobilization of Candida rugosa lipase on a carrier selected from the group consisting of macroporous adsorbent resin of the acrylic type, synthetic epoxy activated resin and Mg—Al-hydrotalcite enhances its enantioselectivity by six to seven folds. The immobilized Candida rugosa lipase is suitable for use in resolution of racemic alcohols and/or... Agent: Birch Stewart Kolasch & Birch
20090035835 - Method and device for producing biomass of photosynthesizing microorganisms/phototrophical algae and biomass of these microorganisms pigments: The invention relates to biotechnology, in particular to methods and means of physical action on biological structures of photosynthesing microorganisms, phototrophic algae in particular. The invention can be used in pharmaceutical, cosmetic and foodstuff industries, as well as for obtaining biofuel from algae In the process of the method implementation... Agent: Vladimir Slavin
20090035836 - Modulating ph-sensitive binding using non-natural amino acids: The invention provides methods, systems and reagents for regulating pH-sensitive protein interaction by incorporating non-natural amino acids into the protein (e.g. an antibody, or its functional fragment, derivative, etc.). The invention also relates to specific uses in regulating pH-sensitive binding of antibodies to tumor site, by conferring enhanced tumor-specificity/selectivity. In... Agent: Seed Intellectual Property Law Group PLLC
20090035838 - Microfabricated crossflow devices and methods: A microfluidic device for analyzing and/or sorting biological materials (e.g., molecules such as polynucleotides and polypeptides, including proteins and enzymes; viruses and cells) and methods for its use are provided. The device and methods of the invention are useful for sorting particles, e.g. virions. The invention is also useful for... Agent: Townsend And Townsend And Crew, LLP
20090035837 - Virus production: An improved process for recovery of virus from allantoic fluid of virus-infected chick embryos. Virus associated with granular and fibrous debris in the allantoic fluid can be disassociated from the debris and recovered, thereby increasing viral yield. Dissociation can be achieved by subjecting the virus-debris complex to conditions of increased... Agent: Marshall, Gerstein & Borun LLP
20090035839 - Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof: A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA,... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090035840 - Thermacetogenium phaeum consortium for the production of materials with enhanced hydrogen content: An isolated microbial consortium is described that includes a first microbial consortium having Thermacetogenium phaeum to metabolize a complex hydrocarbon substrate into metabolic products comprising an acetate compound. The consortium also includes a second microbial consortium having a methanogen to convert the acetate compound into a final product that includes... Agent: Townsend And Townsend And Crew, LLP
20090035841 - Enzymatic production of glycolic acid: Various methods are provided for the enzymatic production of glycolic acid from glycolonitrile. These methods include: 1) use of Acidovorax facilis 72W nitrilase mutants having improved nitrilase activity for converting glycolonitrile to glycolic acid, and 2) methods to improve catalyst stability and/or productivity. The methods to improve catalyst stability/productivity include... Agent: Woodcock Washburn LLP
20090035842 - Sucrose feedstock utilization for oil-based fuel manufacturing: The invention provides methods of manufacturing oils and oil-based products such as transportation fuels, industrial chemicals, edible oils, lubricants and plastics using sugar cane, sugar beets, and cane/beet agricultural processing byproducts as a feedstock for bioproduction processes. The disclosed processes utilize oil-bearing microbes as a conversion technology to convert chemical... Agent: Townsend And Townsend And Crew, LLP
20090035843 - Liquid mycorrhiza compositions: The present invention relates to liquid mycorrhiza compositions and to methods for colonizing a plant, grass, tree or shrub with one or more mycorrhizas.... Agent: Novozymes North America, Inc.
20090035844 - Mechanical cell wounder device and related method: Disclosed is a device and related method for biological manipulation. With greater particularity, disclosed is a novel device and method for uniform cellular manipulation with economies of scale and operational uniformity. The device and related method utilize a cellular wounder (101) to uniformly remove portions of a cell monolayer in... Agent: Fay Sharpe LLP
20090035845 - Method and device for extracting and/or collecting blood from placenta and/or umbilical cord: A device for extracting and collecting blood from a delivered placenta comprising a compartment to contain and support a delivered placenta and umbilical cord. The compartment includes a flexible membrane which can be displaced (preferably under the influence of a fluid (preferably gas) pressure differential between the compartment side and... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20090035846 - Device for measuring extracellular potential and method of manufacturing device: A device for measuring an extracellular potential of a test cell includes a substrate having a well formed in a first surface thereof and a first trap hole formed therein. The well has a bottom. The first trap hole includes a first opening formed in the bottom of the well... Agent: Wenderoth, Lind & Ponack L.L.P.
20090035847 - Centrifugal force-based microfluidic device for nucleic acid detection and microfluidic system including the same: Provided are a centrifugal force-based microfluidic device for separating and amplifying a nucleic acid of a target cell and a microfluidic system including the same. The microfluidic device includes a rotary platform; a target cell nucleic acid extraction unit; and a polymerase chain reaction (PCR) unit wherein in a microfluidic... Agent: Sughrue Mion, PLLC
20090035848 - Moving bed biofilm reactor (mbbr) system for conversion of syngas components to liquid products: A moving bed bioreactor (MBBR) produces liquid products from a gaseous substrate of CO and/or CO2/H2 using a biomass that grows on the surface of carrier suspended in a fermentation broth into which the gaseous substrate is at least partially dissolved. The injection devices include gas spargers and preferably a... Agent: Cardinal Law Group
20090035849 - Depletion of plasma proteins: m
20090035850 - P49/strap is a novel protein involved in gene regulation and cell proliferation: The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in... Agent: Hugh Mctavish Mctavish Patent Firm
20090035851 - Modulators of nod1 signaling: The present invention relates to intracellular signaling molecules, in particular the Nod1 protein. The present invention provides methods of identifying modulators of Nod1 signaling. The present invention further provides methods of altering Nod1 signaling.... Agent: Casimir Jones, S.c.
20090035854 - Methods and compositions for the specific inhibition of gene expression by double-stranded rna: The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090035852 - Stable atomic quantum clusters, production method thereof and use of same: Stable atomic quantum clusters, AQCs, characterized by being composed of at least 500 metal atoms, its production process characterized by having a kinetic control and by maintaining a low concentration of reagents in the reaction medium, as well as the uses of these clusters as sensors (fluorescent, magnetic or chemical),... Agent: Darby & Darby P.C.
20090035853 - Tsg101-gag interaction and use thereof: Isolated protein complexes are provided comprising Tsg101 and HIV GAG or GAGp6. The protein complexes are useful in screening assays for selecting compounds effective in modulating the Tsg101-HIV GAG or GAGp6 interaction within the protein complexes.... Agent: Myriad Genetics Inc. Intellecutal Property Department
20090035855 - Three-dimensional reconstituted extracellular matrices as scaffolds for tissue engineering: A biomaterial scaffold comprising: a) reconstituted extracellular matrix; and b) polyelectrolyte complex fibers; wherein the matrix and the fibers are functionally associated.... Agent: Townsend And Townsend And Crew, LLP
20090035856 - Continuous perfusion bioreactor system: Systems and methods for containing and manipulating liquids, including vessels and unit operations or components of cell culture, cell containment, bioreactor, and/or pharmaceutical manufacturing systems, are provided. In certain embodiments, such vessels and unit operations are directed to continuous perfusion reactor or bioreactor systems and may include one or more... Agent: Xcellerex, Inc. Attention: Jacqueline Arendt
20090035857 - Cell culture processing devices and methods: Embodiments are directed to devices and methods for processing, cultivating or otherwise manipulating cell cultures which may be disposed on a flat or substantially flat surface such as cell culture substrate material. Devices and methods are disclosed for dividing a cell culture layer into divided portions, including isolated divided portions,... Agent: Invitrogen Corporation C/o Intellevate
20090035858 - Tissue engineering support: Cell cultures or tissue engineering supports, include at least a porous matrix based on a collagen sponge which defines first pores and a porous three-dimensional knit which defines second pores, the porous matrix filling the three-dimensional knit and all the first and second pores being at least partially interconnected with... Agent: Carter, Deluca, Farrell & Schmidt, LLP
20090035859 - Method and devices for preventing restenosis in cardiovascular stents: Described herein are devices and methods fabricating devices having nanostructures that allow adhesion or growth of one cell type, such as endothelial cells, more than another cell type, such as smooth muscle cells. In particular, stent covers having such nanostructures are described, and methods for fabricating these stent covers. Also... Agent: Shay Glenn LLP
20090035860 - Stem cell growth media and methods of making and using same: The invention provides media formulations. A complete media formulation of the invention includes, for example, the following components: albumin, an iron carrier, glutamine, a glycosidase or hydrolase, fibroblast growth factor (FGF), a salt or mineral, and essential amino acids, at an osmolarity of about 220-330 mOsm/Liter.... Agent: Pillsbury Winthrop Shaw Pittman LLP
20090035861 - Rnai medicine having no adverse effects: An shRNA used for sequence-specific RNA interference without interferon and/or cytotoxicity induction and a medicine and a reagent containing the shRNA are provided, such shRNA comprising a sense strand comprising a sequence homologous to a target sequence of the target mRNA and an antisense strand comprising a sequence complementary to... Agent: Birch Stewart Kolasch & Birch
20090035862 - Methods and compositions for genomic modification: The present invention provides methods of site-specifically integrating a polynucleotide sequence of interest in a genome of a eucaryotic cell, as well as, enzymes, polypeptides, and a variety of vector constructs useful therefore. In the method, a targeting construct comprises, for example, (i) a first recombination site and a polynucleotide... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP
20090035863 - Method for the deletion of a large chromosomal region: In order to efficiently delete a large chromosomal region with a length of from several tens to hundreds kb such as a cluster of biosynthesis genes encoding a toxic substance such as Aflatoxin, the present invention provides a method for the deletion of a large chromosomal region comprising transforming a... Agent: Birch Stewart Kolasch & Birch
20090035864 - Plasmids for transforming bacteria of the acidithiobacillus spp. genus, and transformation method: The present invention discloses functional plasmids in bacteria of the Acidithiobacillus genus, such as the Acidithiobacillus ferrooxidans, Acidithiobacillus thiooxidans and Acidithiobacillus caldus species. And a method to successfully transform bacteria of the Acidithiobacillus genus, such as the Acidithiobacillus ferrooxidans, Acidithiobacillus thiooxidans and Acidithiobacillus caldus species, with these plasmids.... Agent: Merchant & Gould PCPrevious industry: Education and demonstration
Next industry: Chemistry: analytical and immunological testing
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