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Chemistry: molecular biology and microbiology January recently filed with US Patent Office 01/09Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 01/29/2009 > patent applications in patent subcategories. recently filed with US Patent Office
20090029340 - Cryoprotective compositions and methods of using same: A cryoprotective composition which comprises nanostructures, liquid and at least one cryoprotective agent is provided.... Agent: Foley And Lardner LLP Suite 500
20090029341 - Sample support and sample store, especially for the cryopreservation of biological samples: A sample support (100, 101, 102, . . . ), in particular for cryopreservation of biological samples, is described and includes: a holder part (10) with a sample receiving chamber (11), a retaining device (12, 13) on which a sample can be disposed, and support connecting elements (14, 15) which... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
20090029342 - Medium and method for preserving platelets, red blood cells, and other non-nucleus cells and platelets-containing composition: The present invention provides a platelet-containing composition prepared by contacting platelets with a medium for preserving. The medium comprises anticoagulant, cryoprecipitate and thrombin. The present invention also provides a method for long-term preservation of platelets, comprising the steps of: (a) adding an anticoagulant, cryoprecipitate, thrombin in normal saline; (b) adding... Agent: Bacon & Thomas, Pllc
20090029344 - Compositions and assays utilizing adp or phosphate for detecting protein modulators: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the... Agent: Townsend And Townsend And Crew, LLP
20090029343 - Methods for isolation and analysis of sialylated and phosphorylated peptides: Changes in sialylation of cell surface or plasma proteins are often associated with various cancers and other disease conditions Provided are methods of detecting biomarkers of conditions associated with a change of sialylation status. Sialylated peptides are first isolated from biological and other samples by loading onto titanium dioxide (TiO2)... Agent: Budde, Schou & Ostenfeld, A/s
20090029345 - Modulating skeletal muscle: Methods of identifying skeletal muscle activators are provided. Methods of activating skeletal muscle using skeletal muscle activators are also provided.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090029346 - Detection of human papilloma virus: An assay for detecting HPV comprising treating the viral nucleic acid with an agent that modifies cytosine to form derivative viral nucleic acid, amplifying at least a part of the derivative viral nucleic acid to form an HPV-specific nucleic acid molecule, and looking for the presence of an HPV-specific nucleic... Agent: Knobbe Martens Olson & Bear LLP
20090029348 - Kit for detecting the antibody of hcv and its preparing method: A kit and its preparing method concerning dual-antigen sandwich method are used for detecting the antibody against HCV, and its detecting mode is ‘carrier-first antigen-antibody against HCV to be detected-second antigen-marker-distinguishable signal’. The kit ant its preparing method characterize in that the second antigen is the complex of a HCV... Agent: Marshall, Gerstein & Borun LLP
20090029352 - Method for detecting the presence of a nucleic acid in a sample: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.
20090029347 - Method for identifying multiple analytes using flow cytometry: The present disclosure is directed to a method of using antibodies attached to different types of microspheres against different antigens located within a biological sample. Optical and electronic particle detection may be used to separate the microspheres via flow cytometry, allowing the subsequent measurement of multiple analytes in a single... Agent: Lanier Ford Shaver & Payne P.c.
20090029351 - Method of measuring human cyp3a inducibility: e
20090029349 - Novel applications of acridinium compounds and derivatives in homogeneous assays: Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus to inhibit pseudo-base... Agent: Siemens Corporation Intellectual Property Department
20090029350 - Rapid diagnostic method for distinguishing allergies and infections and nasal secretion collection unit: A method for clinical scoring that involves evaluating certain parameters found in nasal secretia is disclosed. Contact of a nasal secretion with indicators for pH, protein content, leukocyte esterase activity, nitrite content, eosinophil content and/or TAME esterase activity permits diagnosis and differentiation between allergic, bacterial and viral conditions.... Agent: Timothy H. Van Dyke Beusse Brownlee Wolter Mora & Maire, P. A.
20090029355 - Abnormalities of phosphatase 2a (pp2a) for diagnosis and treatment of alzheimer's disease: This invention relates to methods of diagnosing Alzheimer's disease and methods of screening for compounds for the treatment or prevention of Alzheimer's disease. The methods are based upon newly discovered differences in protein phosphatase 2A (PP2A) function and related molecular events in Alzheimer's disease cells compared to control cells. In... Agent: Milbank, Tweed, Hadley & Mccloy LLP
20090029372 - Adam12 as a biomarker for bladder cancer: Particularly ADAM12 mRNA expression was significantly upregulated in bladder cancer, as determined by microarray analysis, and the level of ADAM12 mRNA correlated with disease stage. ADAM12 protein expression correlated with tumor stage and grade. ADAM12 was present in higher levels in the urine from bladder cancer patients than in urine... Agent: Knobbe Martens Olson & Bear LLP
20090029382 - Characterization of a membrane estrogen receptor: The present invention discloses the identification of a novel membrane associated estrogen receptor, termed mER. The membrane associated receptor is involved in rapid signal transduction. Amino acid sequences, nucleic acid sequences, vectors, and host cells are also discussed. Additionally, methods of detecting agonists and antagonists for the receptor are disclosed... Agent: Wyeth C/o Darby & Darby, P.c.
20090029356 - Corynebacterium glutamicum genes encoding novel proteins: Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090029377 - Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing: Embodiments of this invention provide methods, systems, and apparatus for determining whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a pregnant female. Nucleic acid molecules of the biological sample are sequenced, such that a fraction of the genome is sequenced. Respective amounts of a clinically-relevant chromosome... Agent: Townsend And Townsend And Crew, LLP
20090029359 - Diagnostic methods for early cancer detection: The present disclosure is directed to compositions and methods for detecting signs of telomere dysfunction as diagnostic indicators of metastatic disease. More particularly, diagnostic reagents and procedures are provided for analyzing samples to detect elevated expression of TRK2 protein or detect the presence of telomere fusions as an early diagnostic... Agent: Barnes & Thornburg LLP
20090029362 - Gene copy number profiling: The invention relates to copy number profile analysis. Specifically, copy number profile analysis is used to determine whether two or more separate tumors in a single individual are derived from a common source.... Agent: Myriad Genetics Inc. Intellecutal Property Department
20090029379 - Genetic markers for prognosis of antifolate treatment efficacy: Methods and kits for predicting the efficacy of antifolate (e.g., methotrexate) treatment of rheumatoid arthritis by detecting polymorphisms, particularly single nucleotide polymorphisms, in adenosine pathway genes.... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090029375 - Genetic models for stratification of cancer risk: The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of in multiple selected genes to identify individuals with increased or decreased risk of breast cancer. In addition, personal history measures such as age and family history are used... Agent: Fulbright & Jaworski L.l.p.
20090029369 - Genetic selection system to identify proteases, protease substrates and protease inhibitors: The present invention concerns a tester protein for identifying and/or monitoring protease activity in a cellular assay suitable for high throughput screenings by growth selection, wherein the tester polypeptide is a non-regulatory protein carrying a protease cleavage sequence. Upon co-expression of the protease recognizing said cleavage sequence the tester protein... Agent: Marshall, Gerstein & Borun LLP
20090029361 - Growth differentiation factor-7: The present invention provides methods of using polynucleotides that hybridize specifically with a polynucleotide encoding GDF-7 to identify GDF-7 in a sample.... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper Us LLP
20090029376 - High fidelity restriction endonucleases: Compositions and methods are provided for enzymes with altered properties that involve a systematic approach to mutagenesis and a screening assay that permits selection of the desired proteins. Embodiments of the method are particularly suited for modifying specific properties of restriction endonucleases such as star activity. The compositions include restriction... Agent: Harriet M. Strimpel, D. Phil.
20090029378 - High sensitivity multiparameter method for rare event analysis in a biological sample: A sample of blood containing CTCs, or other cells of interest, is stained with fluorescent markers for image analysis and scanned to identify the presence and location within the cartridge of target cells or subcellular elements. A sample containing desired target cells or subcellular elements is then further processed, in... Agent: Philip S. Johnson Johnson & Johnson
20090029380 - Human muty: A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid... Agent: Myriad Genetics Inc. Intellecutal Property Department
20090029386 - Kit for enumerating mammalian cell micronuclei with an emphasis on differentially staining micronuclei and the chromatin of dead and dying cells: The present invention relates a method for the enumeration of mammalian cell micronuclei, while distinguishing micronuclei from the chromatin of dead and dying cells. The method utilizes differential staining of chromatin from dead and dying cells, to distinguish the chromatin from micronuclei and nuclei that can be detected based upon... Agent: Nixon Peabody LLP - Patent Group
20090029368 - Method for determining the cell culture history of a cell unit labelled with more than one type of tag: The present invention relates in one aspect to a method for determining the cell culture history of a cell unit labelled with more than one type of tag comprising the steps of: (a) measuring one or more parameters of each tag that is used to label the cell unit; (b)... Agent: Edwards Angell Palmer & Dodge LLP
20090029371 - Method for determining vasoreactivity: The present invention is generally directed to methods and materials for determining the genotype of a patient to predict the patient's vasoreactivity. More particularly, the present invention is directed to a method of determining the vasoreactivity of a subject, comprising: obtaining from a subject a sample comprising a nucleic acid... Agent: Brinks Hofer Gilson & Lione/utah Utah Office
20090029357 - Method for diagnosing cancer using cancer-associated deletion gene marker: It is an object of the present invention to provide a novel method for diagnosing cancer by discovering a cancer-associated gene which could not be detected by a conventional technique, and detecting deletion, mutation, or an abnormal expression level of such cancer-associated gene. The present invention provides a method for... Agent: Birch Stewart Kolasch & Birch
20090029373 - Method for the quantitative detection of nucleic acids: Provided herein is a method for the quantitative detection of HHV-6 subtypes A and/or B based on the use of a calibrator, suitable primers and probes, and a nucleic acid polymerase with 5′-3′ nuclease activity.... Agent: Nixon & Vanderhye, Pc
20090029363 - Method of selection by two-dimensional separation, of nucleic acids that bind to a target with high affinity: The invention relates to a method of selection, by two-dimensional separation, of nucleic acids that bind to a target molecule with high affinity from a mixture of nucleic acids, including the following steps: a) subjecting the mixture of nucleic acids to a physico-chemical separation step, thereby obtaining a set of... Agent: Mayer & Williams Pc
20090029354 - Method on clinical applications in head neck cancer by using dsg3 molecule for predicting malignant degree of cancer, serving as a molecular target and using rna jamming sequence on inhibition-specific of dsg3 expression: The present invention provide a method for analyzing the DSG3 overexpression in tumor tissues with clinical features of cancer cells to validate that DSG3 overexpression is relates to size, depth and migration of tumor. Therefore, DSG3 overexpression is capable for using in clinical applications, determining malignant degree of tumor, serving... Agent: Nikolai & Mersereau, P.a.
20090029381 - Methods and compositions for analyzing ahasl genes: The invention relates to methods and compositions for analyzing plant acetohydroxy acid synthase large subunit (AHASL) genes. In particular, the invention relates to methods for the detection of wild-type AHASL alleles and mutant AHASL alleles that encode imidazolinone-tolerant AHASL proteins. The methods involve the use of PCR amplification and novel... Agent: Alston & Bird LLP Basf Corporation
20090029358 - Methods and compositions for the diagnosis and treatment of schizophrenia: Compositions and methods relating to the diagnosis and treatment of neuropsychiatric disorders, such as schizophrenia, schizoaffective disorders, and bipolar disorders are disclosed. Also provided are methods for screening therapeutic agents having efficacy for the treatment of such disorders.... Agent: Dann, Dorfman, Herrell & Skillman
20090029366 - Methods of identifying modulators of hyperpolarization-activated cyclic nucleotide-gated (hcn) channels: Methods, including high-throughput methods, for identifying modulators of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.... Agent: Pillsbury Winthrop Shaw Pittman, LLP
20090029353 - Molecular detector: Described herein are embodiments of a method and device comprising an electronic charge detector capable of detecting the presence of small quantities of electric charge generated through a universal signal generation process that is configured to detect any biological agents and biomolecular targets of interest. Electric charge results from signal... Agent: Paul Roath
20090029385 - Molecular redundant sequencing: Methods, systems and compositions where a target nucleic acid includes a registration sequence disposed therein for identification of the number or relative position of determined sequence from the template sequence. Particularly preferred aspects include a registration sequence in a circular template nucleic acid sequence which is, in turn, used in... Agent: Pacific Biosciences Of California, Inc.
20090029365 - Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of colon cancer: The invention relates to newly discovered nucleic acid molecules and proteins associated with colon cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human colon cancers are provided.... Agent: Fish & Richardson P.c.
20090029360 - Nucleic acid amplification and detection of mycobacterium species: Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus Mycobacterium are disclosed. Kits including such oligonucleotides are disclosed. Methods of detecting Mycobacterium species using the oligonucleotides in in vitro nucleic acid amplification are disclosed.... Agent: Gen Probe Incorporated
20090029367 - Polymorphisms in pon1 are associated with elevated alanine aminotransferase levels after ximelagatran or tacrine administration: This invention relates to a method for administering a pharmaceutically useful anticoagulant drug to certain suitable patients and a method for identifying those patients suitable for receiving the drug. In particular, the invention surrounds the identification of an association between certain SNPs in the PON1 gene and susceptibility to increased... Agent: Astrazeneca R&d Boston
20090029383 - Polynucleotide sequencing method: The subject invention pertains to a method for determining the sequence of a polynucleotide comprising the steps of (i) contacting a polynucleotide processive enzyme immobilised in a fixed position, with a target polynucleotide under conditions sufficient to induce enzyme activity; (ii) detecting an effect consequent on the interaction of the... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090029370 - Real time nucleic acid detection in vivo using protein complementation: The present invention relates to a method to detect nucleic acid molecules, such as RNA molecules in vivo using real time protein complementation methods. The invention further relates to methods for detecting nucleic acids, for example RNA in real-time in living cells with a high sensitivity, using a novel split... Agent: Ronald I. Eisenstein
20090029364 - Specific multiplex analysis of nucleic acids: A method of detecting the presence or absence of variant nucleotides within target nucleic acid sequences, said method comprising the use of at least one pair of target-specific amplification primers capable of hybridizing to target nucleic acid sequences, and the use of at least one set of diagnostic primers, each... Agent: Jacobson Holman Pllc
20090029374 - System and method for identifying networks of ternary relationships in complex data systems: A system and method for identifying high order associations between variables in complex systems that is particularly useful where there is no correlation or weak correlation between variables due to the influence of a third variable, a ternary relationship. The ternary relationship describes how the variation in the pattern of... Agent: John P. O'banion O'banion & Ritchey LLP
20090029384 - Techniques for recording signals: The present invention provides techniques of recording signals. In one aspect of the invention, a method of recording a signal comprises the following steps. One or more errors are selectively introduced during synthesis of a polymer in response to the signal. The one or more occurrences of the one or... Agent: Ryan, Mason & Lewis, LLP
20090029388 - Detection of antibodies: The present invention relates to a method for detecting antibodies against a target antigen in a sample which comprises contacting the sample with labelled target antigen, subjecting the sample to immunoprecipitation to precipitate antibodies in the sample and detecting the presence of antibodies against the target antigen in the sample... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.
20090029389 - Fluorescent metal ion indicators with large stokes shifts: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the... Agent: Invitrogen Corporation C/o Intellevate
20090029387 - Method for effectively measuring the activity of cytotoxic t lymphocytes in human and out-bred animals: A method for measuring the activity of cytotoxic T lymphocytes (CTLs) includes preparing peripheral blood mononuclear cells (PBMCs) from blood of an animal; preparing mature dendritic cells by isolating monocytes from the PBMCs, differentiating the monocytes into dendritic cells for presenting an antigen molecule and pulsing dendritic cells with the... Agent: The Rafferty Patent Law Firm
20090029393 - Method for preparing antibodies selective for activating fc receptors: The present invention relates to a method for preparing an antibody selective for activating antibody Fc region receptors (FcRs) comprising an ITAM motif or motifs (immunoreceptor tyrosine-based activation motif), comprising the steps of obtaining monoclonal antibodies from a hybridoma, from a heterohybridoma or from any animal, plant or human cell... Agent: Marsh, Fischmann & Breyfogle LLP
20090029394 - Novel assay for the detection of an antibody bound to a cell membrane receptor: This invention relates to the design of a novel immunoassay specific for the measurement of humanized antibody, Campath-1H, bound to the CD52 cell membrane receptor. The method can be used for pharmacokinetic studies and for monitoring purposes. The invention reveals improvements in higher specificities and sensitivities that can be obtained... Agent: Birch Stewart Kolasch & Birch
20090029395 - Methods for detection of chlamydia in samples: This invention relates to assays for Chlamydia which include the step of inactivating lipid oxidation activity in a biological sample, such as a blood or serum sample. This inactivation improves the detection of Chlamydia antigens or anti-Chlamydia antibodies. Methods and materials for the detection of Chlamydia and Chlamydial infection are... Agent: Nixon & Vanderhye, Pc
20090029392 - Magnetic-nanoparticle conjugates and methods of use: The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked... Agent: Fish & Richardson Pc
20090029391 - Reagents and methods for the determination of pk/adme-tox characteristics of new chemical entities and of drug candidates: Methods using colloidal conductive polymers, noble metal nanoparticles or of stable metal/conductive polymer composite colloids as reagents for at least the in vitro prediction of, if not the determination of, PK/ADME-tox properties of new chemical entities (NCEs) are provided. Also provided are kits that include the subject methods and reagents... Agent: Bozicevic, Field & Francis LLP
20090029396 - Assay kit and antibody for human low molecular weight cd14: The present invention provides an antibody prepared using a peptide as an antigen, the peptide having 8 to 30 amino acid residues selected from an amino acid sequence at positions 1 to 68 of human high-molecular-weight CD14, or an antibody that binds to a peptide having a specific amino acid... Agent: Birch Stewart Kolasch & Birch
20090029397 - Method for monitoring tocolytic treatment: A method of monitoring tocolytic therapy in a pregnant woman. The method comprises determining a first concentration of placental protein 13 (PP13) in a bodily substance of a woman who has not received treatment with a tocolytic agent, determining a second concentration of PP13 in a bodily substance of the... Agent: The Nath Law Group
20090029398 - Microbial atp extraction and detection system: The present invention is directed to compositions and methods for single-step extraction and detection of ATP levels from microbial cells. The disclosed compositions are formulated to efficiently elicit bioluminescent detection of ATP among a broad variety of different microorganisms using a common single-step reagent composition. Additional luminescence-based methods are provided... Agent: Brinks Hofer Gilson & Lione
20090029399 - Method for rapid determination of thiopurine methyltransferase activity: This document provides methods and materials related to rapid, quantitative determination of TPMT activity in biological samples. Also featured are compositions and kits useful for determination of TPMT activity in biological samples.... Agent: Fish & Richardson P.c.
20090029400 - Pharmaceuticals and methods for treating hypoxia and screening methods therefor: Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the... Agent: Fibrogen, Inc. Legal - Ip
20090029401 - Method for detecting biofuel producing microbes: A method for detecting biofuel producing microbes in a colorimetric assay by providing a microbe, a feedstock, and an assay solution. The assay solution contains an alcohol oxidase, a peroxidase, and a peroxidase co-substrate. The microbe is cultured with the feedstock as part of a culture medium that produces a... Agent: Rockey, Depke & Lyons, Llc
20090029402 - Assessment of biological or chemical samples: A method for monitoring consumption or release of a gaseous analyte such as oxygen by a liquid sample under investigation includes providing a cuvette (1) having an elongate narrow tube (12) of a material which is substantially gas impermeable and which is at least partly transparent to measurement excitation radiation... Agent: Jacobson Holman Pllc
20090029405 - Large stoke shift nir dyes: m
20090029404 - Modulation of aqueous humor outflow by targeting vascular-endothelial-cadherin in schlemm's canal cells: The present invention provides methods of inhibiting cadherins between Schlemm's canal cells, to a patient suffering from glaucoma as well as screening for substances that inhibit cadherins between the Schlemm's canal cells.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.
20090029406 - Npy y4 agonist as therapeutic agent for disease accompanied by intestinal tract dysfunction: The present invention has its object to provide an agent capable of ameliorating the intestinal tract dysfunction through a novel mechanism of action. It also has its object to provide a method for the evaluation of a compound, including the screening of the agent. A disease accompanied by intestinal tract... Agent: Merck And Co., Inc
20090029403 - Sesnsor for detecting a toxic or hazardous gas mixture and operating method: A sensor for detecting a gas mixture which substantially comprises air and contains one or a plurality of gases that exhibit a disadvantageous effect on living organisms, comprising: a sensor chip composed of silicon for reading out at least one signal which is generated at a sensitive substance given the... Agent: Staas & Halsey LLP
20090029407 - Systems and methods for analyzing and manipulating biological samples: A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnetic field to the... Agent: Martin D. Moynihan Prtsi
20090029408 - Methods for characterizing cell proximity: One aspect of the invention relates to a method of identifying cell adjacency in a coculture of cells. The method includes generating a first set of image data of the coculture of cells, the first set of image data comprising nuclear position data for each imaged cell; generating a second... Agent: Choate, Hall & Stewart LLP/wyeth
20090029409 - Method for determination of oxidative stress: Provided is a biomarker that enables easy and rapid detection of oxidative stress on a living organism and enables prevention of tissue damage or cell necrosis by drug administration, and which is a powerful marker for the study of toxicity and pharmacokinetics of various agents. Oxidative stress is determined by... Agent: Clark & Elbing LLP
20090029410 - Lipases from thermophilic anaerobes: The inventors have identified polypeptides having lipase activity in anaerobic thermo-philic bacteria. Accordingly, the invention provides a process for hydrolyzing an ester bond in a substrate, which comprises treating the substrate with a particular lipase (a polypeptide having lipase activity). The invention also provides a lipase for use in the... Agent: Novozymes North America, Inc.
20090029411 - Biomaterial capable of successively performing a solution/gel transition and then a gel/solution transition: The invention relates to a biomaterial which can successively carry out a solution/gel transition then a gel/solution transition with given kinetics, said biomaterial comprising at least one monomer which may form polymers, at least on enzyme which may decompose said polymers and, optionally, an enzyme which may form covalent bonds... Agent: Choate, Hall & Stewart LLP
20090029414 - Cell-free synthesis of membrane bound polypeptides: Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of high yields of membrane- associated polypeptides.... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP
20090029413 - Process for the manufacture of a composite material: t
20090029412 - Solubility tags for the expression and purification of bioactive peptides: Peptide tags, referred to here as inclusion body tags, are disclosed useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a product that... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090029416 - Hyperthermostable protease gene: There are provided hyperthermostable proteases having an amino acid sequences represented by SEQ ID Nos. 1, 3 and 5 of the Sequence Listing or functional equivalents thereof and hyperthermostable protease genes encoding those hyperthermostable protease. There is also disclosed a process for preparation of a hyperthermostable protease by culturing a... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090029418 - Method for cloning and expression of stui restriction endonuclease and stui methylase in e. coli: The present invention relates to compositions including: (1) isolated DNA encoding the Stul restriction endonuclease and isolated DNA encoding cognate and non-cognate methylase; (2) vectors and cells containing the isolated DNA; and (3) methods for producing the Stul restriction endonuclease.... Agent: New England Biolabs, Inc
20090029415 - Peripheral nervous system specific sodium channels, dna encoding therefor, crystallization, x-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof: Cloning, expression, viral and delivery vectors and hosts which contain nucleic acid coding for at least one peripheral nervous system specific (PNS) sodium channel peptide (SCP), isolated PNS SCP, and compounds and compositions and methods, are provided, for isolating, crystallizing, x-ray analysing molecular modeling, rational drug designing, selecting, making and... Agent: Townsend And Townsend And Crew, LLP
20090029417 - Recombinant microorganism: The object of the invention is to provide a microorganism which enhances productivity of cellulase and is useful for industrial production of cellulase, and to provide a method for producing cellulase by use of the microorganism. The present invention provides a recombinant microorganism produced by transferring a gene encoding cellulase... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20090029419 - Expression of modified antibodies in avian cells: The present invention relates to construct and methods which allow the expression of immunoglobulins or functional fragments thereof which have been altered to that they are humanised. The expression of the immunoglobulins or fragments thereof takes place in avian cells, and the constructs used have been altered such that the... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20090029420 - Acid-resistant solubility tag for the expression and purification of bioactive peptides: An acid-resistant peptide solubility tag (an “inclusion body tag”) is provided that is effective in producing peptides of interest in an insoluble form. Fusion peptide constructs comprising the inclusion body tag fused to a peptide of interest are provided. An acid cleavable peptide moiety separates the inclusion body tag from... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center
20090029422 - Reactor plate and reaction processing method: The reactor plate preferably includes a sealed reactor, a reactor flow channel connected to the reactor, a sample container constituted from a sealed container provided separately from the reactor, a sample container flow channel to be connected to the sample container, a syringe for sending a liquid, a switching valve... Agent: Cheng Law Group, Pllc
20090029421 - Recombinase polymerase amplification: The present invention features novel, diverse, hybrid and engineered recombinase enzymes, and the utility of such proteins with associated recombination factors for carrying out DNA amplification assays. The present invention also features different recombinase ‘systems’ having distinct biochemical activities in DNA amplification assays, and differing requirements for loading factors, single-stranded... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo
20090029423 - Method for separating target component: A construct in which at least a part of the magnetic material is coated with a polyhydroxyalkanoate (PHA), and a method for producing a construct by immobilizing a PHA synthesizing enzyme on the surface of the magnetic material, thereby biosynthesizing and coating a PHA.... Agent: Fitzpatrick Cella Harper & Scinto
20090029424 - Recombinant enzyme with altered feedback sensitivity: The present invention relates to the use of recombinant homoserine transsuccinylase enzymes with altered feedback sensitivity (MetA*) and possibly recombinant S-adenosyl methionine synthetase enzymes with reduced activity (MetK*) for the production of methionine, its precursors or derivatives thereof.... Agent: Ip Group Of Dla Piper Us LLP
20090029425 - Process for the production of beta-lysine: Process for the production of -lysine by constructing a recombinant microorganism which has a deregulated lysine 2,3-aminomutase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diamino-pimelate dehydrogenase, arginyl-tRNA... Agent: Connolly Bove Lodge & Hutz, LLP
20090029426 - Process for preparing rapamycin 42-esters and fk-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies: Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional activated ester of dicarboxylic acid with a lipase.... Agent: Howson And Howson/wyeth Cathy A. Kodroff
20090029427 - Increased yield in gas-to-liquids processing via conversion of carbon dioxide to diesel via microalge: The present invention is generally directed to systems and methods for integrating gas-to-liquids (GTL) processing with biofuels production. In some embodiments of the present invention, carbon dioxide (CO2) generated by GTL processing is used to support grovel (via photosynthesis) of microalgae. In some such embodiments, the microalgae can be further... Agent: Chevron Services Company Law, Intellectual Property Group
20090029428 - Novel microorganism, lipid-modifying agent, and the method of manufacturing 2-acyl lysophospholipids: The present invention provides a new supply source of phospholipase A1, which is useful for phospholipid modification and lipid biochemical research, and offers a method capable of efficiently manufacturing a large amount of high DHA content phospholipids and lysophospholipids. A novel microorganism HFKI-0020 (FERM AP-20545) of the genus Pseudomonas which... Agent: Oliff & Berridge, Plc
20090029429 - Process for producing optically active 2-substituent-oxy-3-(4-substituent-oxyphenyl) propionic acid derivative: The present invention relates to a process for producing an optically active 2-substituent-oxy-3-(4-substituent-oxyphenyl)propionic acid derivative which comprises stereoselectively reducing an 2-oxo-3-(4-substituent-oxyphenyl)propionic acid by an enzyme and subjecting the thus-obtained optically active 2-hydroxy-3-(4-substituent-oxyphenyl)propionic acid to esterification of the carboxyl group according to need, then to alkylation of the hydroxyl group and,... Agent: Connolly Bove Lodge & Hutz LLP
20090029430 - Novel carbonyl reductase, gene therefor and use thereof: The present invention is to provide a process for efficiently producing an optically active alcohol including (R)-3-hydroxy-3-phenylpropanenitrile. One of the features of the present invention is a polypeptide having an activity of asymmetrically reducing 3-oxo-3-phenylpropanenitrile isolated from a microorganism belonging to the genus Candida to produce (R)-3-hydroxy-3-phenylpropanenitrile, DNA encoding the... Agent: Sughrue Mion, Pllc
20090029431 - Process for the preparation of 1,3-propanediol by a recombinant micro-organism in the absence of coenzyme b12 or one of its precursors: The invention concerns a method for preparing 1,3-propanediol from a carbon-containing substance, said method comprising a step which consists in culturing a recombinant micro-organism not producing coenzyme B12 in the absence of coenzyme B12 or one of its precursors. The invention also concerns a nucleic acid coding for a glycerol... Agent: Fulbright & Jaworski L.l.p.
20090029432 - Dry fractionation of corn: Novel grain processing methods and the products obtained therefrom are disclosed. Methods may include separation of pericarp fractions, hydrolysis of the pericarp fractions one or more time, and fractionation of the hydrolyzed pericarp fractions. Hydrolyzed pericarp fractions have applications including fermentation media, livestock feed, and fuel feedstocks.... Agent: Buchanan Ingersoll & Rooney Pc
20090029433 - Hydrogen producing microorganism useful for energy generation from diverse carbohydrates: The disclosed invention relates to an isolated hydrogen gas producing microorganism, termed Enterobacter sp. SGT 06-1™.... Agent: Patentique Pllc
20090029434 - Modular membrane supported bioreactor for conversion of syngas components to liquid products: A modular membrane supported bioreactor for anaerobic conversion of gas into liquid products including membrane module(s) having a plurality of hollow fibers packed across a cross sectional area of the membrane module in a direction transverse to the axis of the membrane module; a membrane vessel for retaining the membrane... Agent: Cardinal Law Group
20090029435 - Deactivation of linking moieties in antibody-enzyme conjugates: In some embodiments, the present invention pertains to a method for conjugating a first compound to a second compound wherein the conjugation involves an electrophilic moiety. The method comprises reacting the first compound with the second compound to form a conjugate. The improvement in embodiments of the present invention comprises... Agent: Dade Behring Inc. Legal Department
20090029436 - Substantially pure reverse transcriptases and methods of production thereof: The present invention provides substantially pure reverse transcriptases, which are preferably substantially free from contamination with nucleic acids. The invention also provides methods for the production of these enzymes, and kits comprising these enzymes which may be used in synthesizing, amplifying or sequencing nucleic acid molecules, including through the use... Agent: Invitrogen Corporation C/o Intellevate
20090029438 - Composite materials comprising supported porous gels: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20090029437 - Novel glucose dehydrogenase and method for producing the dehydrogenase: A novel glucose dehydrogenase, which is an enzyme that has high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal stability is obtained by culturing a microorganism belonging to the genus Burkhorderia and having... Agent: Knobbe Martens Olson & Bear LLP
20090029439 - Regeneration: The invention relates to the filed of regeneration of cells, self-renewal of (micro-organisms), and the vegetative propagation of plant parts such as plant tissues or organs.... Agent: Hoffmann & Baron, LLP
20090029440 - Lipase variants: The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.... Agent: Novozymes North America, Inc.
20090029441 - Bionanomaterials and their synthesis: The use of biomaterials, such as viruses and virus-like particles, to form nanostructures is generally disclosed. For instance, rod-like viruses can be used to form composite nanofibers that are fixed together in a head-to-tail assembly by a polymer. Also, 2-dimensional nanostructures formed from crosslinked viruses assembled in a single, film-like... Agent: Dority & Manning, P.a.
20090029442 - Estrogenic substance degradable microorganism and use thereof: A microorganism capable of degrading an estrogenic substance contained in wastewater and the like; a method for the simple and effective degradation of an estrogenic substance contained in domestic wastewater, wastewater discharged from a livestock farm, or the like by using the microorganism; and an apparatus for achieving the degradation... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.
20090029443 - Compositions and methods for enhanced bacterial exopolysaccharide production: The present invention provides nucleic acid sequences and variants thereof capable of modulating exopolysaccharide production in Sphingomonas, and provides methods of using such nucleic acid sequences to generate bacteria that hyper-produce exopolysaccharide in slime form.... Agent: Seed Intellectual Property Law Group Pllc
20090029444 - Novel recombinant anticoagulant proteins: Novel recombinant anticoagulation proteins, methods of their use and methods of their production are described. In particular, recombinant fusions of annexin V (ANV) and Kunitz protease inhibitors (KPI) that possess potent anticoagulant activity are provided. The fusions, abbreviated ANV:KPI, utilize ANV having high affinity for phosphatidyl-L-serine with various KPI's to... Agent: Sonnenschein Nath & Rosenthal LLP
20090029445 - Algae growth system for oil production: A biological growth reactor vessel for the cultivation of micro-algae, diatoms or other unicellular organisms, especially for oil production, is described which incorporates a dispensing rod to which are attached a plurality of clear paddles which increase surface area for the diffusion of light and growth enhancing admixtures such as... Agent: Wesley B. Ames
20090029448 - Compost heat recovery system and method: In a composting system for outdoor operation for large-scale composting of municipal and other wastes, one or more large compost piles or windrows are supported on a pad, and covered with a removable cover. Fluid circulation pipes are embedded within the pad, to recover heat generated by aerobic decomposition of... Agent: The Webb Law Firm, P.c.
20090029446 - Integrated process for conversion of hydrocarbonaceous assets and photobiofuels production: The present invention is generally directed to processes that integrate CO2-producing conversions of hydrocarbonaceous assets with biofuels processes that utilize CO2 in photosynthesis. In some embodiments, such processes involve the absorption of CO2 in an absorption liquid. In some such embodiments, such absorption is carried out in an absorption tower.... Agent: Chevron Services Company Law, Intellectual Property Group
20090029447 - Process for removing mercury from air or water: The present invention provides for the removal of mercury utilizing Mer proteins. After the Mer proteins have been expressed and isolated, or alternatively using the native Mer protein complex, either can be used as a chelating agent to remove mercury from any aqueous mercury containing environment. The Mer protein may... Agent: West Virginia University Research Corporation
20090029449 - Method and apparatus for substantially isolating plant tissues: The present invention discloses and claims methods and devices for the rapid mechanical isolation of monocot plant tissues suitable for transformation or tissue culture. The invention includes mechanical devices for substantially isolating target plant tissues for use as transformable explants, and propagation of transgenic plants and plant tissues.... Agent: Sonnenschein Nath & Rosenthal LLP
20090029450 - Incubator: An accommodating unit capable of accommodating a culture vessel, a transfer unit supporting and transferring the culture vessel, and taking in and out the culture vessel relative to the accommodating unit, and an observation unit observing a sample inside of the culture vessel via an observation optical system under a... Agent: Oliff & Berridge, Plc
20090029451 - Sterilization challenge specimen holder: A sterilization challenge specimen holder is used with a test indicator to challenge sterilization on a consistent basis. The holder includes a body having an internal chamber region. A cap is sealable on the holder. A plug is positioned in the body. The plug has a wall having a spiral... Agent: Levenfeld Pearlstein, Llc Intellectual Property Department
20090029452 - Apparatus and method for analyte detection: Disclosed is a testing device and methods for the identification of an analyte of interest in a sample. In a preferred embodiment, the testing device includes a front panel having at least one sample application aperture; a rear panel having at least one solvent application aperture; a sample collection matrix... Agent: Foley & Lardner LLP
20090029453 - Devices for the detection of multiple analytes in a sample: The present invention relates generally to an assay for detecting and differentiating multiple analytes, if present, in a single fluid sample, including devices and methods therefore.... Agent: Morrison & Foerster LLP
20090029454 - Sample block apparatus and method for maintaining a microcard on a sample block: A thermal cycling device for thermally cycling samples of biological material contained in a microcard having a top and bottom surface. The thermal cycling device can include a sample block having an upper surface configured for engaging the bottom surface of a microcard, a vacuum device, and a temperature control... Agent: Harness, Dickey & Pierce, P.L.C
20090029455 - Chimeric t1r1 taste receptor encoding nucleic acid sequences and vectors: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department
20090029457 - Pharmaceutical composition for inducing an immune response in a human or animal: The present invention relates to a pharmaceutical composition for inducing an immune response in a human or animal, comprising dendritic cells loaded with at least five cancer/testis antigen and no lineage specific differentiation antigens or substantially no lineage specific differentiation antigens provided from at least one cancer cell line, as... Agent: Birch Stewart Kolasch & Birch
20090029456 - Str50 and uses thereof: The present invention relates to use of a novel gene, STR50 and to STR50 modulators in diagnostic, therapeutic and screening aspects related to neurotoxic events. More particularly, the present invention concerns diagnosing and treating neurodegenerative diseases, and screening for species which can be useful in treating the same.... Agent: Cooper & Dunham, LLP
20090029458 - Chicken leukemia inhibitory factor (lif) and gene thereof: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for... Agent: Rader Fishman & Grauer Pllc
20090029459 - Method for the cultivation of primary cells and for the amplification of viruses under serum free conditions: The present invention relates to a method for the cultivation of primary cells. The primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of growth factors and attachment factors. The method for the cultivation of primary cells may be one step in... Agent: Law Office Of Salvatore Arrigo
20090029460 - Neoplasm-specific polypeptides and their uses: The present invention features novel polypeptides and methods of using these polypeptides in the diagnosis detection, monitoring, and treatment of neoplasms in mammal, e.g., a human.... Agent: Clark & Elbing LLP
20090029461 - Immortalised feeder cells: The invention relates to an immortalized feeder cell line. The immortalized feeder cell line may be derived from an embryonic fibroblast, which may be a mouse embryonic fibroblast. A culture of an immortalized feeder cell line according to the invention in a suitable culture medium is also provided, as is... Agent: The Firm Of Hueschen And Sage
20090029462 - Automated method and apparatus for embryonic stem cell culture: The invention concerns methods for automated culture of embryonic stem cells (ESCs) such as human ESCs. In some aspects, methods of the invention employ optimized culture media and limited proteolytic treatment of cells to separate cell clusters for expansion. Automated systems for passage and expansion of ESCs are also provided.... Agent: Fulbright & Jaworski L.l.p.
20090029465 - Culturing human embryonic stem cells: Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells in an undifferentiated state. It has now been found that if high levels of fibroblast growth factor are... Agent: Quarles & Brady LLP
20090029463 - Differentiation of multi-lineage progenitor cells to chondrocytes: Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described, as well as methods of differentiating the progenitor cells into chondrocytes.... Agent: Fish & Richardson P.c.
20090029464 - Feeder independent extended culture of embryonic stem cells: Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells in an undifferentiated state. It has now been found that if an antagonist of bone morphogenic protein is... Agent: Quarles & Brady LLP
20090029466 - Methods and compositions for the specific inhibition of gene expression by double-stranded rna: The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed to compositions that contain double stranded... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.
20090029467 - Method for targeting lysosomal enzymes: Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic agent and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor.... Agent: Choate, Hall & Stewart LLP
20090029468 - Zinc finger binding domains for cnn: Polypeptides that contain zinc finger-nucleotide binding regions that bind to nucleotide sequences of the formula CNN are provided. Compositions containing a plurality of polypeptides, polynucleotides that encode such polypeptides and methods of regulating gene expression with such polypeptides, compositions and polynucleotide's are also provided.... Agent: Schwegman, Lundberg & Woessner, P.a.
20090029469 - Method for in vitro proliferation of dendritic cell precursors and their use to produce immunogens: A method for producing proliferating cultures of dendritic cell precursors is provided. Also provided is a method for producing mature dendritic cells in culture from the proliferating dendritic cell precursors. The cultures of mature dendritic cells provide an effective means of producing novel T cell dependent antigens comprised of dendritic... Agent: Merix Bioscience, Inc.
20090029470 - Process and culturing unit for culturing biological cells: A targeted cultivation phase adjustment is provided in a process for the cultivation of cells in which biological cells are cultivated on at least one boundary surface between different, non-solid cultivation phases so that pre-determined cultivation conditions are given. A cultivation apparatus (100) for biological cells is also provided that... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
20090029471 - Microelectromechanical devices useful for manipulating cells or embryos, kits thereof, methods of making same, and methods of use thereof: The present invention relates generally to microelectromechanical systems (MEMS) devices for the manipulation of cells or groups of cells, such as oocytes, embryos, and sperm. In particular, the present invention relates to Cell Labeling MEMS devices (2F), Microinjection MEMS devices, IntraCytoplasmic Sperm Injection (“ICSI”) MEMS devices, Zona Coring MEMS devices,... Agent: Mathews, Shepherd, Mckay & Bruneau, P.a.01/22/2009 > patent applications in patent subcategories. recently filed with US Patent Office
20090023127 - Tissue system and methods of use: Apparatus and methods of use of a tissue system for culture and perfusion. The apparatus comprises a needle for injecting a fluid into the tissue.... Agent: Intellectual Property / Technology Law
20090023128 - Storage device for cryopreservation of biological samples: A cryopreservation storage device (100), in particular for cryopreservation of biological samples, comprises a plurality of multi sample modules (20) being adapted for accommodating the biological samples and sample memories, a module control device (30) controlling an access to sample memories accommodated by the multi sample modules (20), and a... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.
20090023130 - Prevention of transfusion related acute lung injury using riboflavin and light: This invention is directed toward a method of preventing the formation of bioactive substances in a pathogen inactivated blood component. The steps include illuminating the blood component with light at a sufficient energy so that an alloxazine photosensitizer present in the blood component may be photolyzed to inactivate any pathogens... Agent: Caridianbct, Inc. Mail Stop: 810 1f2
20090023129 - White blood cell differentiation reagent and method of use thereof: The present disclosure provides a white blood cell differentiation reagent comprising a fluorescent dye compound of Formula I, wherein R1, R2, R3, R4, Y− and n are as defined in the specification. The present disclosure also provides a white blood cell detection kit comprising the white blood cell differentiation reagent,... Agent: Mindray C/o Stoel Rives LLP
20090023131 - Circuit arrangement for injecting nucleic acids and other biologically active molecules into the nucleus of higher eucaryontic cells using electrical current: The invention relates to a novel circuit arrangement for electrotransfection or electrofusion, which enables the transportation of DNA and/or other biologically active molecules to the nucleus of higher eukaryotic cells or the fusion of cells, independent of cell division and with reduced cell mortality.... Agent: Darby & Darby P.c.
20090023132 - Hydraulic device for a blood analysis apparatus, associated method and analysis apparatus equipped with such a device: Hydraulic device for a blood analysis apparatus includes elements 302, 106 for injecting a flow of blood sample into a flow-through optical tank 300 and for creating a flow of sleeving liquid 303 around the sample flow, with a sleeving liquid. The device also includes elements 134, 150 for adjusting... Agent: Young & Thompson
20090023133 - Genomic markers of hepatitis b virus associated with hepatocellular carcinoma: The present invention provides methods of predicting a pre-disposition of HBV-infected individuals to develop hepatacellular carcinoma (HCC).... Agent: Townsend And Townsend And Crew, LLP
20090023140 - Crosslinking agent, crosslinking method, method of controlling gene expression, and method of examining gene function: According to the present invention, crosslinking between double-stranded nucleic acids between a nucleic acid and a protein or a polypeptide, or between proteins or polypeptides, in particular, between double-stranded RNA can be easily formed, and in addition, the crosslinking can also be easily removed, so that the expression of a... Agent: Leydig Voit & Mayer, Ltd
20090023135 - Detection of enhanced multiplex signals by surface enhanced raman spectroscopy: Various methods of using Raman-active or SERS-active probe constructs to detect analytes in biological samples, such as the nucleic acid and/or protein-containing analytes in a body fluid are provided.... Agent: Client 21058 C/o Darby & Darby P.c.
20090023146 - Device for processing an analyte and a method of processing and/or detecting an analyte using said device: The present invention relates to a device for processing an analyte and to a method of processing and/or detecting an analyte using said device.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.
20090023147 - Diagnostics and therapeutics for osteoporosis: Diagnostics and therapeutics for osteoporosis, which are bases upon the identification of a subjects IL-1 haplotype and genotype pattern are described.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20090023150 - Dna diagnostics based on mass spectrometry: Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processes can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection... Agent: Grant Anderson LLP C/o Portfolioip
20090023137 - Esr1 and cervical cancer: The present invention provides methods and kits for detecting susceptibility to, or the incidence of, cervical cancer in a sample comprising determining the methylation status of the ESR1 gene, optionally as part of a panel of genes. Also provided are methods and kits which involve determining the expression levels of... Agent: Foley And Lardner LLP Suite 500
20090023136 - Hsd3b1 sequence variants: Isolated HSD3B1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as are HSD3B1 allozymes. Methods for determining whether a subject contains an HSD3B1 sequence variant also are provided.... Agent: Fish & Richardson P.c.
20090023144 - Method and its kit for quantitatively detecting specific analyte with single capturing agent: The invention provides a method and its kit for quantitatively detecting a specific analyte with a single capturing agent. The quantitative detection of a specific analyte with a single capturing agent comprises: firstly combining the tested analyte with a solid phase capturing agent, then labeling analyte which has been trapped... Agent: Schmeiser, Olsen & Watts
20090023141 - Method for detecting bacteria of the genus mycobacterium (acid-fast bacteria) and kit for the same: An object of the present invention is to provide an oligonucleotide for rapidly and conveniently detecting bacteria of the genus Mycobacterium (acid-fast bacteria) or for identifying the bacterial species thereof, and a method and kit for detecting bacteria of the genus Mycobacterium (acid-fast bacteria) using such oligonucleotid. The present invention... Agent: Birch Stewart Kolasch & Birch
20090023139 - Method for site-specifically introducing non-natural amino acid into protien using mitochondrial protein and method for effectively preparing trna: This invention is intended to provide a protein synthesis system used for producing a tryptophan analogue-containing non-natural-amino-acid-containing protein that satisfies the following conditions: (i) tRNA that transfers a non-natural amino acid is not recognized by an endogenous aminoacyl tRNA synthetase (aaRS); (ii) it is recognized selectively by aaRS exclusive for... Agent: Birch Stewart Kolasch & Birch
20090023151 - Method for the labeling and detection of small polynucleotides: Methods and kits for use in isolating, labeling or detecting a small polynucleotide of interest from a sample. The method entails hybridizing the small polynucleotide to a capture probe, lengthening the small polynucleotide by primer extension and/or ligation, and degrading the capture probe to provide a single stranded extension product.... Agent: Sheldon Mak Rose & Anderson Pc
20090023142 - Methods for detecting minimum residual disease: The present invention features methods and compositions for identifying markers of minimum residual disease (MRD), as well as markers of metastatic cells. The present invention further provides methods for detecting MRD and metastatic cell in a subject.... Agent: Edwards Angell Palmer & Dodge, LLP
20090023145 - Methods of diagnosing or prognosing alzheimer's disease: e
20090023149 - Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy: The present invention features methods, kits, and devices for predicting the sensitivity of a patient to a compound or medical treatment. The invention also features methods for identifying gene biomarkers whose expression correlates to treatment sensitivity or resistance within a patient population or subpopulation.... Agent: Clark & Elbing LLP
20090023134 - Neoplasia diagnostic compositions and methods of use: The invention generally features compositions and methods for the diagnosis and monitoring of a neoplasia (e.g., a prostatic neoplasia) in a subject, as well as methods of treatment selection.... Agent: Edwards Angell Palmer & Dodge LLP
20090023138 - Oral cancer markers and their detection: Methods of detecting progression from precancer to cancer are provided utilizing toluidine blue staining as well as detecting allelic variation at microsatellite loci. An allelic variation in one or more locus is indicative of a progression from precancer to cancer.... Agent: Jeffer, Mangels, Butler & Marmaro, LLP
20090023143 - Predicting agent for metastasis: By disclosing part of metastasis mechanisms in cancer cells, the metastatic potential of cancer cells will be determinable. Anti-galectin-9 Ab against galectin-9 is contained as an effective component with or without others, thereby enabling the evaluation or detection of galectin-9 expression levels in cancer cells wherein the metastatic potential of... Agent: Wenderoth, Lind & Ponack, L.l.p.
20090023154 - Relating to marking: The invention provides a marking system, markers and methods of use of such marking systems and markers which enable unique marking of articles and subsequent detection of that marking. In particular the invention provides a marking system, the marking system comprising a plurality of different DNA fragment types, each of... Agent: Merchant & Gould Pc
20090023148 - Sensors for biomolecular detection and cell classification: A sensor device is provided for detecting an analyte in a sample in which an analyte is bound to a detection reagent to form a bound complex. The device comprises (a) a sample (5) comprising an ionic analyte and a detection reagent in a conductive fluid, wherein the detection reagent... Agent: Richard R. Muccino
20090023153 - Targeted modification of chromatin structure: Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.... Agent: Robins & Pasternak
20090023152 - Transcription factor mhc class ii genes, substances capable of inhibiting this transcription factor and medical uses of these substances: The present invention relates to a transcription factor of MHC class II genes and its derivatives, inhibitors down-regulating the expression of MHC class II molecules, process to identify these inhibitors and medical uses of these inhibitors.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20090023158 - Compositions and methods for identifying substrate specificity of inhibitors of gamma secretase: The invention provides assays and methods for determining the substrate specificity of gamma secretase inhibitors and for identifying substrate-selective (and substrate isoform-selective) inhibitors of gamma secretase. The invention provides assays and methods for determining whether a compound inhibits gamma secretase in a site specific or substrate specific manner. The invention... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090023156 - Methods and reagents for quantifying analytes: The present invention relates to methods and reagents for quantifying analytes. More specifically, the present invention related to methods and reagents for measuring one or more analytes present in a sample.... Agent: Morgan, Lewis & Bockius, LLP.
20090023155 - Polyelectrolyte multilayer films at liquid-liquid interfaces and methods for providing and using same: The present invention is directed to methods for providing a polyelectrolyte multilayer film at a liquid-liquid interface. Such methods include steps of sequentially-depositing layers of cationic and anionic polyelectrolytes at a liquid-liquid interface that is formed between immiscible first and second liquids whereby a polyelectrolyte multilayer film is provided at... Agent: Quarles & Brady LLP
20090023157 - Proteome epitope tags and methods of use thereof in protein modification analysis: Disclosed are methods for reliably detecting the presence of proteins, especially proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc.) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a set of proteins (Proteome Epitope Tags,... Agent: Goodwin Procter LLP Patent Administrator
20090023159 - Method for the in vitro diagnosis of alzheimer's disease using a monoclonal antibody: The invention relates to a method for the in vitro diagnosis of Alzheimer's disease using a monoclonal antibody. Said antibody can bind at least to amino acids 12-16 of the β-amyloid peptide, specifically detecting the neuritic plaques which are characteristic of Alzheimer's disease, without detecting diffuse plaques which are not... Agent: Ladas & Parry LLP
20090023160 - Antibodies specific for cyp1b1: Antibodies that can specially bind to cytochrome P450 CYP1B1 and methods of making them are disclosed, in particular antibodies that bind to amino acid sequence VNQWSVNHDPVKWPN or PExFDPARFLDKDGy, where x is D or N and y is L or F, or an antigenic fragment thereof. The antibodies can be used... Agent: Quine Intellectual Property Law Group, P.c.
20090023161 - Structural basis for targeting hiv-1 gag proteins to the plasma membrane for virus assembly: The present invention provides for testing methods to determine an effective testing agent that affects the activity of the HIV Gag protein at the plasma membrane of a cell, and specifically, effecting changes in the structural conformation of at least one fatty acid of PI(4,5)P2, a member of a family... Agent: Moore & Van Allen Pllc
20090023162 - Method for the identification of atypical p-anca: The invention relates to a method for the identification of atypical p-ANCA, kits suitable for the same and application of said method to the diagnosis of chronic inflammatory intestinal diseases and autoimmune liver diseases.... Agent: Joyce Von Natzmer Pequignot + Myers Llc
20090023163 - Method of measuring enzyme activity and method of evaluating compound: It is intended to provide a method of measuring an activity, which is a method of measuring an activity of an enzymatic reaction in which a lipid-soluble reaction product is formed by catalyzing an addition reaction of two or more kinds of substrates, characterized by comprising a labeling step in... Agent: Merck And Co., Inc
20090023164 - Compositions and methods for the detection of hiv-1/hiv-2 infection: This invention relates to compositions and methods or the detection of immunodeficiency virus infection, especially immunodeficiency virus-1 (HIV-1) infection. The invention particularly concerns compositions and methods that may be used in HIV vaccine recipients whose sera may contain vaccine-generated anti-HIV-1 antibodies.... Agent: Woodcock Washburn LLP
20090023166 - Method for the in vitro diagnosis of autoimmune immune response by detection of antibodies directed against the pentraxin 3 antigen: A method for the in vitro diagnosis of an autoimmune immune response in an individual by detection, in a biological fluid from said individual, of antibodies directed against the pentraxin 3 (PTX3) antigen, characterized in that the presence of antibodies directed against the PTX3 antigen (anti-PTX3 antibodies) are determined in... Agent: Pauley Petersen & Erickson
20090023165 - Methods for early diagnosis of kidney disease: The invention provides reagents and methods for diagnosing kidney disease in a human or animal.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090023167 - Method, reagent and kit for determination of cholesterol in remnant-like particles (rlp): The present invention provides a method, a reagent and a kit for simple and sensitive determination of cholesterol in remnant-like particles without separation of components of a sample. A method for quantitatively determining remnant-like particle cholesterol in a sample, which comprises: in an aqueous medium containing the sample and in... Agent: Fitzpatrick Cella Harper & Scinto
20090023169 - High throughput sarcomeric assay: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.... Agent: Townsend And Townsend And Crew, LLP
20090023168 - Method of screening placental proteins responsible for pathophysiology of preeclampsia, and marker for early diagnosis and prediction of preeclampsia: The present invention relates to a method of screening placental proteins responsible for pathophysiology of preeclampsia, and a marker for early diagnosis and prediction of preeclampsia. In accordance with one aspect of the present invention, there is provided a method of screening placental proteins responsible for pathophysiology of preeclampsia by... Agent: Christie, Parker & Hale, LLP
20090023172 - Gtp cyclohydrolase ii as a target for fungicides: The present invention relates to the identification of fungal GTP cyclohydrolase II as a target for fungicides, to a method for identifying antifungal agents based on fungal GTP cyclohydrolase II, and also to the use of compounds identified as fungicides via the abovementioned method.... Agent: Brinks, Hofer, Gilson & Lione
20090023173 - Luminescence-based methods and probes for measuring cytochrome p450 activity: The invention provides compounds, compositions, methods, substrates, and kits useful for analyzing the metabolic activity in cells, tissue, and animals and for screening test compounds for their effect on cytochrome P450 activity. In particular, a one-step and two-step methods using luminogenic molecules, e.g. luciferins or coelenterazines, that are cytochrome P450... Agent: Schwegman, Lundberg & Woessner, P.a.
20090023171 - Method for determining specific groups constituting heparins or low molecular weight heparins: The invention provides methods for analysing heparins, low-molecular-weight heparins, ultralow-molecular-weight heparins, and oligosaccharides by high performance liquid chromatography a stationary phase dynamically coated with a quaternary ammonium salt. The methods of the invention may be used to analyse samples without pre-treatment or to analyse samples that have been partially or... Agent: Sanofi - Aventis / Finnegan Henderson LLP
20090023170 - Methods and kits for the detection of biotoxic and antibiotic residues: The invention provides a kit for the detection of antibiotic residues comprising inducible bacterial spores which produce an induced enzyme after germination and induction; a germinant that triggers rapid germination of said spores; an inducer that triggers the production of the specific enzyme of interest; a substrate upon which said... Agent: Baker Botts LLP C/o Intellectual Property Department
20090023174 - Methods and compositions for detecting immune responses: Methods and compositions for detecting immune responses and antigen-specific cells are described herein.... Agent: Leydig, Voit & Mayer, Ltd.
20090023177 - Assays and methods for determining stim2 activity: The present invention provides assays and methods for determining levels of STIM2 activity, thus providing tools for the characterization and study of the regulation of intracellular calcium levels.... Agent: Morgan, Lewis & Bockius, LLP
20090023175 - Device for sampling a fluid and detecting an analyte therein: Provided is a device for detecting an analyte in a fluid comprising a first compartment (1) having an open end (1.2) and a closed end (1.1) wherein said closed end holds a medium (1.3) comprising a substance with which said analyte can be detected and a second compartment (2) having... Agent: Nixon & Vanderhye, Pc
20090023176 - Devices, systems and methods for isometric and isotonic contraction of blood vessels using an isovolumetric myograph: The present invention discloses devices, systems and methods for the isovolumic measurement of vasoactivity in a blood vessel (3). The length and volume of the blood vessel (3) are maintained constant while a chemical or pressure is exposed to the blood vessel (3). The reaction of the blood vessel (3)... Agent: Ice Miller LLP
20090023178 - Parkin substrate and assay: The invention provides in vitro, ex vivo, and in vivo assays for Parkin activity, in which Parkin-mediated ubiquitination of a Sept4 protein is measured. The assays may be used to screen for agents that modulate Parkin protein ligase activity.... Agent: Townsend And Townsend And Crew, LLP
20090023180 - Reduction of shading in microalgae: Methods provided herein are directed to increasing the efficiency of light utilization of photosynthetic microorganisms. Also provided are screening assays, genetic constructs, and photosynthetic microorganisms for increasing light utilization efficiency and production of molecules such as ATP, oxygen, hydrogen, and recombinant proteins. Methods provided herein can be performed with any... Agent: Beyer Weaver LLP
20090023181 - Method and device for detection of erythromycin-induced clindamycin resistance: A device and method are provided for determination of erythromycin-induced clindamycin resistance. The device is preferably a test panel containing one or more wells each having a known concentration(s) of erythromycin and known concentration(s) of clindamycin. After inoculation of the wells with a sample and incubation, the wells are analyzed... Agent: Dade Behring Inc. Legal Department
20090023182 - Complementary metabolizing organisms and methods of making same: The invention provides a non-naturally occurring set of microbial organisms. The set of organisms includes: at least a first constituent complementary metabolizing organism (CMO) exhibiting the ability to metabolize a first carbon substrate and having substantially impaired metabolic capacity for a second carbon substrate, and at least a second constituent... Agent: Mcdermott, Will & Emery
20090023183 - Method for preparing recombinant peptide from spider venom and analgesic composition containing the peptide: The present invention relates to a method for producing a recombinant, spider toxin peptide and analgesic compositions containing said peptide. More specifically, the present invention relates to a method in which the gene for GsMTx4 is subcloned into a vector, so that it is linked to a secretion signal sequence... Agent: Sughrue Mion, Pllc
20090023185 - Avidin mutants: Two circularly permuted avidin monomers are designed. The circularly permuted monomers (cpAvd5→4 and cpAvd6→5) are fused and the resulting fusion peptides (dcAvd) form a pseudo-tetrameric dual-chain avidin, which is biologically active in biotin binding and shows similar structural characteristics as wild-type avidin. The dcAvd makes the development of dual-affinity avidins... Agent: Young & Thompson
20090023186 - Use of valproic acid for enhancing production of recombinant proteins in mammalian cells: Culturing cells for the commercial production of proteins for diagnosis and therapy is a costly and time consuming process. The equipment required is expensive, and production cost are high. In order to provide commercially viable processes it is desirable to use cell lines which produce large quantities of product with... Agent: Markus Hildinger
20090023187 - Method of obtaining a product sugar stream from cellulosic biomass: A process for obtaining a product sugar stream from cellulosic biomass is disclosed. In one process, the cellulosic biomass is pretreated at a pH between about 0.4 to 2.0 by adding one or more than one acid to produce a pretreated cellulosic biomass comprising acetic acid. One or more than... Agent: Fitzpatrick Cella Harper & Scinto
20090023188 - Heparin/heparosan synthase from p. multocida and methods of making and using same: The presently claimed and disclosed invention relates, in general, to dual action heparin synthases and, more particularly, to dual action heparin synthases obtained from Pasteurella multocida. The presently claimed and disclosed invention also relates to heparosan, heparin and heparin-like molecules provided by recombinant techniques and methods of using such molecules... Agent: Dunlap Codding, P.c.
20090023189 - Apparatus and methods for preparation of subtantially uniform emulsions containing a particle: Methods and systems for forming water-in-oil emulsions are described. For example, an apparatus is described which includes: a first compartment containing a plurality of particles dispersed in an aqueous phase; a second compartment containing an oil phase; a porous layer separating the first and second compartments; and a device for... Agent: Mila Kasan, Patent Dept. Applied Biosystems
20090023190 - Sequence amplification with loopable primers: The present disclosure relates to the amplification of target nucleic acid sequences. This can be accomplished via the use of various primers. The use of these primers, as described herein, results in nucleic acid structures that can reduce the amplification of nonspecific hybridization events (such as primer dimerization) while allowing... Agent: Knobbe Martens Olson & Bear LLP
20090023191 - Gene rcs 23: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, Pc
20090023192 - Process for producing ethanol: A process for producing ethanol including a combination of biochemical and synthetic conversions results in high yield ethanol production with concurrent production of high value coproducts. An acetic acid intermediate is produced from carbohydrates, such as corn, using enzymatic milling and fermentation steps, followed by conversion of the acetic acid... Agent: Sheridan Ross Pc
20090023193 - Anaerobic reactor and corresponding method for digesting organic material: The present invention is an anaerobic reactor and preferably a vertically oriented plug flow anaerobic reactor for producing methane from various organic materials. The organic materials preferably have a high organic content. The reactor includes cutting members for cutting bridged or agglomerated material within the reactor. The present invention also... Agent: Carlton Fields, P.a. Attn: Ip Dept.
20090023194 - Device and method for the cultivation and generation of biological material in a nutrient mist: The present invention relates to a device and a method for the cultivation and generation of biological material.... Agent: Knobbe Martens Olson & Bear LLP
20090023195 - Bio-based method for making mannitol: Mannitol is produced in a highly efficient fermentative method using Lactobacillus intermedius NRRL B-30560, or in a biochemical method using mannitol dehydrogenase isolated from this strain. Fructose serves as the primary carbon substrate in both the fermentative and biochemical conversions, but important secondary carbon sources include glucose, maltose, mannose and... Agent: Usda-ars-office Of Technology Transfer National Ctr For Agricultural Utilization Research
20090023196 - Stocks of replication-deficient adenovirus: Presented are ways to address the problem of replication-competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with a selected vector are suited for large scale production of recombinant adenoviruses. A system for use with the invention produces replication-defective adenovirus. The... Agent: Trask Britt
20090023197 - Method for purifying a viral suspension: e
20090023198 - Optimizing expression of active botulinum toxin type a: Nucleic acid molecules that comprise modified open reading frames providing increased expression of the encoded active BoNT/A in a heterologous cell, expression constructs and cells comprising such nucleic acid molecules and methods useful for expressing the encoding active BoNT/A from such nucleic acid molecules, expression constructs and cells.... Agent: Allergan, Inc.
20090023199 - Micro-organism production system and method: A micro-organism production system having at least one micro-organism growth unit for maintaining therein micro-organisms in solution. Upon the receipt of a predetermined amount of live organisms, liquid and nutrients within the at least one micro-organism growth unit and the application of radiation thereto, the system produces the rapid growth... Agent: Burns & Levinson, LLP
20090023200 - Particle for detecting enzyme activity, method for detecting the enzyme activity and enzyme activity detection device by the use thereof: The particle 1 for detecting the enzyme activity of the present invention comprises a particle 2 and a first compound 3 binding the particle 2 to one end, binding a first fluorescent group 4 to the other end and having a cleavage site by an enzyme 5 in a sample... Agent: Sughrue Mion, Pllc
20090023201 - Nucleic acid detecting cassette and nucleic acid detecting apparatus: In a nucleic acid detecting cassette in which a heating treatment chamber and a liquid delivery channel are constituted of a stationary member and flexible members, the heating treatment chamber is held by convex heating sections from both sides, whereby the heat treatment chamber and the liquid delivery channel are... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.
20090023202 - Nucleic acid analysis device and nucleic acid analyzer using the same: The present invention relates to a nucleic acid analysis device for analysis of nucleic acid in a sample through fluorometry, in which a localized surface plasmon by light irradiation, and in which a nucleic acid probe or a nucleic acid synthase for the analysis of the nucleic acid in the... Agent: Mcdermott Will & Emery LLP
20090023203 - Sensor device for interrogation of changes in the contents of a sealed container: A device and method allowing evaluation of the contents of a sealed primary container by means of an integral sensor which is separated from the contents of the sealed primary container yet provides information on quality of the contents of the primary container without breaking the sealed system. The integral... Agent: The Webb Law Firm, P.c.
20090023204 - A device for the storage and treatment of biodegradable wet solid waste: The present invention relates to a device for the storage and treatment of biodegradable wet solid waste, especially for vegetarian household waste materials. The device consists of a bucket shaped container with a mesh bottom and a removable cover with a hole at the center. The container is provided with... Agent: Greenlee Winner And Sullivan P C
20090023205 - Method for the separation of living cells: The present in invention relates to a method for the separation of living cells from a mixture of dead and living cells which optionally can also possibly contain cell fragments.... Agent: Mcdermott Will & Emery LLP
20090023206 - Microinjection apparatus and method of injecting fluid: A microinjection apparatus allows a capillary to stick into an object. A discharge pressure is supplied to the capillary. The supplied discharge pressure allows the discharge of a first fluid from the tip end of the capillary. The first fluid is injected into the object. The remains of the object... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20090023207 - Chromosome 3p21.3 genes are tumor suppressors: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90%... Agent: Steven L. Highlander, Fulbright & Jaworski L.l.p. Suite 2400
20090023208 - Cultivation of primate embryonic cells: The invention relates to methods for culturing human embryonic stem cells by culturing the stem cells in an environment essentially free of mammalian fetal serum and in a stem cell culture medium including amino acids, vitamins, salts, minerals, transferring, insulin, albumin, and a fibroblast growth factor that is supplied from... Agent: Quarles & Brady LLP
20090023209 - Solution for the indefinite maintenance of nucleic acids in the cell of origin thereof: The invention relates to a product having characteristics which enable a biological sample obtained from an individual to be maintained under conditions such that the quality of nucleic acids later extracted is not affected, thereby guaranteeing the integrity of the sample regardless of the time that elapses between the sample... Agent: Schiff Hardin, LLP Patent Department
20090023210 - B-cyclodextrin derivatives and their use against anthrax lethal toxin: The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of β-cyclodextrin. Per-substituted alkylamino derivatives displayed inhibitory activity, and they were protective against anthrax lethal toxin action at low micromolar concentrations. Also, the addition... Agent: Keown & Zucchero, LLP
20090023211 - Blood platelet lysate and method of producing the same: A method of preparing a blood platelet lysate starting from platelet-rich plasma from whole blood of animals, to which blood a citrate has been added to prevent coagulation, is described. The method is characterised by concentrating the platelet-rich plasma by ultrafiltration to obtain a plasma that is richer in platelets,... Agent: Buchanan, Ingersoll & Rooney Pc
20090023212 - Method for transforming soybean (glycine max): The present disclosure provides methods for the transformation of soybean cells or tissue and regeneration of the soybean cells or tissue into transformed plants. The disclosed methods utilize an explant prepared from an immature soybean inflorescence, shoot apex, leaf axillary, shoot axillary, or combination thereof which can be induced directly... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20090023213 - Method to increase the rate of transgenic embryo formation after inoculation of immature cotyledons with agrobacterium: The present disclosure provides methods for the transformation of soybean cells or tissue and regeneration of the soybean cells or tissue into transformed plants. The disclosed methods utilize an explant prepared from an immature soybean cotyledon which can be induced directly to form shoots that give rise to transgenic plants... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20090023214 - Rescue of plant cell cultures and suspensions after cryopreservation-induced damage: The subject invention relates to recovery of cryopreserved plant cell cultures after cryopreservation. The use of canine IL-4 and human gamma interferon is exemplified in some preferred embodiments.... Agent: Ronald S. Maciak Dow Agrosciences Llc
20090023216 - Double-stranded oligonucleotides: Antisense sequences, including duplex RNAi compositions, which possess improved properties over those taught in the prior art are disclosed. The invention provides optimized antisense oligomer compositions and method for making and using the both in in vitro systems and therapeutically. The invention also provides methods of making and using the... Agent: Invitrogen Corporation C/o Intellevate
20090023215 - Novel reagents for transfection of eukaryotic cells: Compositions and methods for improved delivery of macromolecules into eukaryotic cells are provided. Fusogenic peptides from fusion proteins of non-enveloped viruses enhance the efficiency of transfection of eukaryotic cells mediated by transfection agents such as cationic lipids, polycationic polymers such as PEI and dendrimers. These fusogenic peptides are used as... Agent: Proskauer Rose LLP01/15/2009 > patent applications in patent subcategories. recently filed with US Patent Office
20090017439 - Compositions and methods for enhancing the viability of animal cells, tissues, and organ explants: Disclosed are compositions and methods for the preservation, storage, and transport of living biological tissues, organs, and populations of isolated cells. In particular, the disclosed compositions and processes permit mammalian cells, tissues, and organs to be harvested from suitable donor animals, stored for prolonged periods, and transported to the site... Agent: Medtronic Attn: Noreen Johnson -IPLegal Department
20090017437 - Fixative composition: The invention relates to a fixative composition for preservation of tissue and biological samples. Current fixative compositions have the drawback that they do not sufficiently protect against DNA/RNA degeneration. In addition their use impairs extractability and compromises amplifiability of extracted DNA. The invention solves the combined but related problems and... Agent: Ladas & Parry LLP
20090017438 - Methods and compositions for the preservation of cells and tissues: Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be harvested from suitable donor animals, stored for prolonged periods under refrigerated, cryogenic,... Agent: Medtronic Attn: Noreen Johnson -IPLegal Department
20090017440 - Increasing the viability and stress tolerance of viable biological material: The present invention relates to a method for improving viability and/or stress tolerance of viable biological material and using the said material comprising applying hydrostatic pressure to said biological material; keeping the said viable biological material at the hydrostatic pressure for a predetermined time period; releasing the hydrostatic pressure; and... Agent: Hahn & Voight PLLC
20090017441 - Asymmetric cyanine fluorescent dyes: The present disclosure provides the asymmetric cyanine fluorescent dyes of formula I in which X, n, R1, R2, R3, R4, R5 and Y− are as defined in the specification. The present disclosure also provides conjugates of the fluorescent dyes, methods for preparation thereof, compositions comprising the fluorescent dyes, and methods... Agent: Mindray C/o Stoel Rives LLP
20090017442 - In-vitro diagnostic medical devices for determining saliva volume: The invention relates to a method of collecting saliva from the oral cavity for detecting a test substance, comprising the steps of (a) cleaning the oral cavity, (b) stimulating saliva secretion with a saliva-collecting solution, (c) removing the saliva-saliva collecting solution mixture from the oral cavity and collecting it in... Agent: Collard & Roe, P.C.
20090017449 - Compounds and methods for assaying fusion of an individual, enveloped virus with target membrane: Compositions and methods for monitoring viral fusion are provided. Methods of labelling virions are also provided. A novel, detectable label is provided. A mobile lipid bilayer is also provided.... Agent: Banner & Witcoff, Ltd.
20090017447 - Human endogenous retrovirus with foamy-like properties and uses thereof: The invention relates to the discovery of a human endogenous retrovirus (HERV) family, Type I HERV-K (HML-2) which appear to be active in vitro and in vivo, infectious, and which have the have the salient features and properties of foamy retroviruses. Based on its natural replication in humans, and that... Agent: Ade & Company Inc.
20090017446 - Method and set of tools for checking the crystallisation conditions of biological macromolecules: The invention relates to a method and set of tools for checking and ascertaining the crystallisation conditions of biological macromolecules using the counter-diffusion technique which employs precipitating agents, additives and buffers. The concentration of the precipitating agent(s) in the medium (solution or gel) is greater than those currently used with... Agent: Wenderoth, Lind & Ponack, L.L.P.
20090017445 - Method for detecting and removing endotoxin: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins... Agent: Fulbright & Jaworski L.L.P.
20090017443 - Method for detection of hepatitus b virus: To provide a method for detection or quantification of hepatitis B virus (HBV) antigens in serum and a simple and highly user-friendly method for sample treatment for use in the detection or quantification thereof. The method for treatment of a sample containing hepatitis B virus (HBV) is characterized in that... Agent: Birch Stewart Kolasch & Birch
20090017444 - Screening method for modulators of viral transcription or replication: The invention provides methods to identify modulators of viral transcription or replication.... Agent: Schwegman, Lundberg & Woessner, P.A.
20090017448 - Screening tool for antiviral agents: A method is provided for screening anti-adenovirus agents. The method includes reducing the activation of the immune system of a small mammal, administering a human adenovirus vector to the small mammal, monitoring the tumor cells in the mammal, and analyzing infectious virus units within the tumor cells and the organs... Agent: Husch Blackwell Sanders LLP
20090017454 - Biosensors, method for obtaining the same and uses thereof: The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090017465 - Compound screening using cardiomyocytes: This invention provides populations human cells of the cardiomyocyte lineage. The cells are obtained by causing cultures of pluripotent stem cells to differentiate in vitro, and then harvesting cells with certain phenotypic features. Differentiated cells bear cell surface and morphologic markers characteristic of cardiomyocytes, and a proportion of them undergo... Agent: Geron Corporation Attn. David J. Earp
20090017456 - Detection, identification and differentiation of eubacterial taxa using a hybridization assay: The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the... Agent: Nixon & Vanderhye, PC
20090017461 - Diagnosis of gynecological neoplasms by detecting the levels of oviduct-specific glycoprotein: The present invention provides a method for detecting cancer in a patient. A sample from the patient is provided, and the level of oviduct-specific glycoprotein (OGP) in the sample is determined and compared to a control sample. Increased levels of OGP in the sample as compared to the control indicates... Agent: Bereskin And Parr
20090017460 - Differential expression profiling analysis of cell culture phenotypes and uses thereof: The present invention provides, among other things, systems and methods for identifying genes and proteins that regulate and/or are indicative of cell phenotypes based on expression profiling analysis. The present invention further provides methods of manipulating identified genes and proteins to engineer improved cell lines.... Agent: Choate, Hall & Stewart LLP
20090017458 - Disease diagnosis apparatus and method using photocurrent of amorphous silicon: Provided is a disease diagnosis apparatus and method for detecting a specific disease. The disease diagnosis chip, includes: a light sensing layer; a probe molecule fixed on the light sensing layer; and an electrode connected to the light sensing layer to detect an electric signal corresponding to photoelectric charges of... Agent: Rabin & Berdo, PC
20090017451 - Generation of recombinant genes in saccharomyces cerevisiae: The present invention relates to methods for generating and detecting recombinant DNA sequences in Saccharomyces cerevisiae and plasmids and Saccharomyces cerevisiae cells used for conducting the inventive methods.... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B482
20090017457 - Identification of modulators of serine protease inhibitor kazal and their use as anti-cancer and anti-viral agents: This invention describes a relevant etiology of cancer and a novel anti-cancer therapeutic strategy, based on the discovery that a protein named serine protease inhibitor (SPIK/SPINK/PSTI) was up-regulated by hepatitis B and C virus infections consequently suppressing the cell apoptosis. Accordingly, this invention provides an inhibitor of SPIK and/or a... Agent: Woodcock Washburn LLP
20090017459 - Measuring analytes using competitive interference and recuperation of enzyme activity: The present teaching generally discloses a method of measuring the concentration of an analyte in a solution. The method includes selecting a binding compound; selecting an analog to an analyte and conjugating the analog to a polynucleotide substrate to construct a reagent for measuring the amount of the analyte in... Agent: Tips Group C/o Intellevate LLC
20090017452 - Methods and compositions relating to the pharmacogenetics of different gene variants: The present invention is directed to methods and compositions for determining the presence or absence of polymorphisms within an ABCC2, UGT1A1, and/or SLCO1B1 gene and correlating these polymorphisms with activity levels of their gene products and making evaluations regarding the effect on their substrates, particularly those substrates that are drugs.... Agent: Fulbright & Jaworski L.L.P.
20090017455 - Methods and systems for detecting and/or sorting targets: Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded-protein and substrate polynucleotides. The polynucleotide-encoded protein is comprised of a protein that specifically binds to a predetermined target and of an encoding polynucleotide that specifically binds to a substrate... Agent: Steinfl & Bruno
20090017464 - Methods for drug discovery, disease treatment, and diagnosis using metabolomics: The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090017463 - Methods for predicting prostate cancer recurrence: The present invention relates to the identification of four cytokine biomarkers in prostatic tissue that exhibit differential expression following prostatectomy that, in combination at least one other factor, are able to reliably predict the development of biochemical recurrence following surgery. This marker combination improves the risk stratification of patients after... Agent: Fulbright & Jaworski L.L.P.
20090017453 - Nicking and extension amplification reaction for the exponential amplification of nucleic acids: The invention is in general directed to the rapid exponential amplification of short DNA or RNA sequences at a constant temperature.... Agent: Grant Anderson LLP C/o Portfolioip
20090017450 - Primer for detection of human papillomavirus: Disclosed are primers specific to the genome of HPV genotypes 11, 16, 18 and 31. Also disclosed are a kit for detecting the HPV genome comprising the primers and a method of detecting the HPV genome using the primers.... Agent: Medlen & Carroll, LLP
20090017462 - Recombinase polymerase amplification: This disclosure describe three related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo Attn: Patent Intake Customer No. 35437
20090017466 - Separation-free assay method: This invention relates to a separation-free assay method employing a binding partner label and a nonspecifically binding label, wherein a signal from said binding partner label or said nonspecifically binding label is measured in a binding event, said method comprising the use of a) two or more binding partners, and... Agent: James C. Lydon
20090017471 - Soluble erbb3 method of detection: The present invention discloses a method using human soluble ErbB3, for example p85-sErbB3, as a negative regulator of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present invention also discloses p85-sErbB3 binding to heregulin with an affinity comparable to that of full-length ErbB3, and competitively inhibiting high affinity heregulin binding to... Agent: Tumor Biology Investment Group, Inc.
20090017472 - Biomarkers predictive of the responsiveness to tnfalpha inhibitors in autoimmune disorders: The invention provides methods for predicting responsiveness to TNFα inhibitors in a subject suffering from an autoimmune disorder, such as rheumatoid arthritis. The methods involve assaying for expression of one or more biomarkers in the subject that are predictive of responsiveness to TNFα inhibitors. A preferred biomarker of the invention... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090017473 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Goodwin Procter LLP Attn: Patent Administrator
20090017474 - Systems and methods for detecting abnormal cells: Systems and methods of interrogating clusters of cells for two or more biological markers that do not, or rarely, occur in the same cell during normal cellular growth, development and function, to indicate the existence of cells that are part of a local area where a pre-neoplastic or neoplastic lesion... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20090017475 - Method to determine pseudo-allergic reactions: Method and kit for determining the possible appearance of adverse reactions (such as anaphylactoid reactions) in patients in need to undergo to an administration of a pharmaceutical compound. The method for determining potential hypersensitivity in a patient to pseudo-allergic reactions comprises adding a predetermined amount of a compound with anaphylatoxic... Agent: Bracco Research Usa Inc.
20090017476 - Multiple component nanoparticles for multiplexed signaling and optical encoding: The present invention provides multiple-luminophore silica nanoparticles for multiplexed signaling in bioanalysis. In specific embodiments, two inorganic luminophores, Tris(2,2′-bipyridyl)osmium(II) bis(hexafluorophosphate) (OsBpy) and Tris(2,2′-bipyridyl)dichlororuthenium(II) hexahydrate (RuBpy), or three organic luminophores 5-Fluorescein isothiocyanate (5-FITC), 5-carboxyrhodamine 6G, succinimidyl ester (5-CR6G, SE), 6-carboxy-X-rhodamine, succinimidyl ester (6-ROX, SE) can be simultaneously entrapped inside silica nanoparticles... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090017467 - Composition exhibiting a von willebrand factor (vwf) protease activity comprising a polypeptide chain with the amino acid sequence aaggilhlellv: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.... Agent: Baxter Healthcare Corporation
20090017477 - Method for determination of concentration, charge or unit size of a substance: This invention relates to a method comprising the steps of a) contacting a sample containing a sample substance and a solid phase comprising a signal element, and optionally a substance containing a signal element, i.e. a signal element substance; wherein at least one of said sample substance, said solid phase,... Agent: James C. Lydon
20090017468 - Method of screening compound directly activating glycogen synthase: The present invention provides a therapeutic agent for diabetes comprising a compound directly activating glycogen synthase as an active ingredient. The present invention further provides a method for screening compounds directly activating glycogen synthase.... Agent: Merck And Co., Inc
20090017470 - Immunological analytical reagent for the determination of advance glycosylation end products (ages): The invention provides a reagent for determination of Advance Glycosylation End Products (AGEs), comprising a suspension disposed with displaying carrier and the antigen or antibody immobilized on the surface of the said displaying carrier; and a test strip, comprising of: a base plate, and constitutive parts provided on said base... Agent: Bacon & Thomas, PLLC
20090017469 - Use of holographic sensor: The present invention relates to a process for the detection of an analyte in a sample, comprising a) bringing the sample into contact with a first ligand which binds specifically to the analyte and which is immobilised on a substrate, and b) prior to or subsequent to step (a), bringing... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090017478 - High-throughput enzyme-linked immuno absorbent assay (elisa) for determination of rho-kinase (rok) activity: The invention is referring to an assay for measuring the activity of a ROK (Rho Kinase) protein by means of a biotinylated peptide.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC
20090017479 - Ly6h gene: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SEQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the... Agent: Sughrue, Mion, Zinn, Macpeak & Seas, PLLC
20090017480 - Bioamplification for microbial sensor signal transduction: A process of detection of the causative agent of Johne's disease (Mycobacterium avium subsp. paratuberculosis) (MAP) by detecting shedding of surface protein of MAP. A preferred way is use of surface enhanced Raman Spectroscopy. The system of detecting MAP shedding of protein provides early detection and diagnosis, and therefore allows... Agent: Mckee, Voorhees & Sease, P.L.C
20090017481 - Method for identifying at least two groups of microorganisms: p
20090017482 - Luminogenic and nonluminogenic multiplex assay: A method to detect the presence or amount of at least one molecule for an enzyme-mediated reaction in a multiplex luminogenic/nonluminogenic assay is provided.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.
20090017485 - Alzheimer's disease examination method: [Means for Solving Problems] A reaction liquor, which is prepared by mixing an amyloid β protein with a body fluid collected from a subject and a buffer solution is reacted. After the polymerization of the amyloid β protein comes to equilibrium, the degree of the amyloid β protein polymerization is... Agent: Kanesaka Berner And Partners LLP
20090017483 - Analytical instrument having improved arrangement of reagent section and analytical method: The present invention relates to an analytical instrument (1) which includes a flow path (5) for moving a sample containing blood cells, an introduction port (50) for introducing the sample into the flow path (5), a reagent portion (51) arranged in the flow path (5), and an electron detection medium... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20090017487 - Biogas production from bmr plants: Methods and compositions to produce biogas and fertilizer from plant material that have reduced lignin content relative to a wild-type plant material, for example, a brown midrib (BMR) plant, are disclosed. Methane yields from BMR plants including BMR corn are significantly higher, thereby increasing the efficiency of methane production. Anaerobic... Agent: Dow Agrosciences LLC
20090017484 - Markers for atherosclerosis: A method for the diagnosis, prognosis or identification of a predisposition towards atherosclerosis and the susceptibility to the development of atherosclerotic plaques and/or vascular obstruction is described, the method comprising analysing a sample to determine the percentage frequency of multiple sub-populations of T-lymphocytes and comparing the data obtained against comparative... Agent: Edwards Angell Palmer & Dodge LLP
20090017486 - Method and test kit for the identification of compounds specifically modulating the action of cortical axo-axonic cells: The present invention provides a method for identifying an agent capable of specifically modulating or eliminating the action of axo-axonic cells, an experimental kit for performing the said method and compounds identifiable by the said method, as well as methods for the treatment or prevention different neurological symptoms by modulating... Agent: Hahn & Voight PLLC
20090017488 - Methods for identifying modulators of ion channels: The invention provides methods for identifying modulators of ion channels without the use of recombinant cell lines over-expressing the ion channel proteins or the use of detection labels.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090017489 - Methods for modulating the development of dopamine neuron by the dopamine d2 receptor and compositions thereof: The present invention relates to a composition for modulating the activation of Nurr1, the composition comprising an agonist or an antagonist of a dopamine D2 receptor, methods for modulating the activation of Nurr1 by the dopamine D2 receptor, a method and composition for treating Nurr1-related diseases using the dopamine D2... Agent: Casimir Jones, S.c.
20090017490 - Dna fragment method for producing transformant for protein production and utilization thereof: An expression vector is constructed by transferring recombinant tomato mosaic virus (ToMV) cDNA, in which a coat protein gene of ToMV having a suppressor against a virus resistant reaction has been substituted by a GFP gene, into the downstream of a promoter capable of inducing steroid hormone-dependent transcription. In a... Agent: Harness, Dickey & Pierce, P.L.C
20090017491 - Apparatus and method for biological sample processing: An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate-supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate... Agent: Ventana Medical Systems, Inc. Attention: Legal Department
20090017493 - Gene sms 02: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, PC
20090017492 - Svph1-26 dna and polypeptides: DNA encoding SVPH1-26 polypeptides and methods for using the encoded proteinase and polypeptides are disclosed. SVPH1-26 is expressed in testis.... Agent: Immunex Corporation Law Department
20090017494 - Tick octopamine receptor nucleic acid molecules, proteins and uses thereof: The present invention relates to tick octopamine receptor nucleic acid molecules; to tick octopamine receptor proteins encoded by such nucleic acid molecules; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain such proteins, nucleic acid... Agent: Heska Corporation Legal Department
20090017495 - Escherichia coli-derived vaccine and therapy against botulism: A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an expression vector comprising DNA encoding HCR protein, (b) inducing expression of the HCR protein at a reduced temperature in a culture... Agent: Quarles & Brady LLP
20090017496 - Co-expression of multiple protein chains or subunits: A recombinant genetic construct is provided that includes at least two expression cassettes. Each cassette encodes for a chain or subunit of a target protein. The genetic construct preferably targets any expressed protein to the secretory pathway of the host cell. An application of present invention is found in expressing... Agent: Duan Wu
20090017498 - Fibroblast growth factor-like polypeptides: The present invention provides novel Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with FGF-like polypeptides.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090017497 - Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast: Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between... Agent: Novo Nordisk, Inc. Intellectual Property Department
20090017500 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department
20090017501 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department
20090017502 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department
20090017499 - Rank ligand-binding polypeptides: The present invention relates to a polypeptide having an amino acid sequence that differs from and is at least 70% identical to the amino acid sequence of hRANK, and which has a binding affinity to RANKL that is at least as high as the binding affinity of hRANK to RANKL,... Agent: Maxygen, Inc. Intellectual Property Department
20090017503 - Method and apparatus for saccharide precipitation from pretreated lignocellulosic materials: A method for separating saccharide components and lignin fractions from a concentrated acid treated lignocellulosic biomass is disclosed. The method involves precipitating the saccharide components by adding an organic solvent to the biomass slurry. The acid may then be recovered, for example, by filtration or by countercurrent washing and the... Agent: Lathrop & Gage Lc
20090017504 - Method for preparing 20-o-beta-d-glucopyranosyl-20(s)-protopanaxadiol (ginsenoside m1) by using sanqi leaves and stems: The present invention provides a method for preparing 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (Ginsenoside M1) by using Sanqis leaves and stems. The method of the invention includes the steps of: (a) provides powder of Sanqi leaves and stems; (b) provides a fungus for fermenting the Sanqi leaves and stems, wherein the fermentation temperature is... Agent: Birch Stewart Kolasch & Birch
20090017505 - Process and device for mixing microdroplets: In a process for mixing microdroplets (2a, 2b, 2c), at least two carriers (3a, 3b) are provided whose surfaces (4a, 4b) are each structured in such a way that at least one hydrophilic surface domain (5a, 5b) is delimited by at least one hydrophobic surface domain (6a, 6b). A first... Agent: The Webb Law Firm, P.C.
20090017506 - Continuous fermentation process to produce bacterial cellulosic sheets: A process to obtain multiple bacterial cellulose sheets without the need to replace new fermentation medium in the tray is provided. The medium is prepared and medium components in water are dissolved. The medium is sterilized and heated to 115° C. for 20 minutes, cooled to 30° C., inoculated with... Agent: Volpe And Koenig, P.C.
20090017507 - Dry granulated product containing l-lysine as main component: Hydrochloric acid, sulfuric acid or an L-lysine solution having an equivalent ratio of anion/L-lysine higher than 0.95 is added to a raw material L-lysine solution having an equivalent ratio of anion/L-lysine lower than 0.68 to adjust the equivalent ratio of anion/L-lysine of the raw material solution to be in the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090017508 - Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins: The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. avermitilis. The present invention further relates to vectors, host cells, and mutant strains... Agent: Pfizer Inc.
20090017509 - Method for the production of ramipril: An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC
20090017510 - Enzymic method for the enantioselective reduction of keto compounds: The invention relates to an enzymatic method for the enantioselective reduction of organic keto compounds to the corresponding chiral hydroxy compounds, an alcohol dehydrogenase from Lactobacillus minor and a method for the enantioselective production of (S)-hydroxy compounds from a racemate.... Agent: Propat, L.L.C.
20090017511 - Alcohol product processes: The present invention relates to processes for production of an alcohol product from granular starch comprising a pre-treatment at an elevated temperature below the initial gelatinization temperature of said granular starch followed by simultaneous saccharification and fermentation, and optionally recovery of ethanol.... Agent: Novozymes North America, Inc.
20090017512 - Apparatus and methods for the production of ethanol, hydrogen and electricity: The compositions, methods and apparatus of the present invention allow the production of electricity, ethanol and hydrogen, and combinations thereof. In some embodiments, the invention provides a process for generating electricity or hydrogen comprising supplying a microbial catalyst and a fuel source to a microbial fuel cell or a bio-electrochemically... Agent: Fulbright & Jaworski L.L.P.
20090017513 - Process for producing hydrocarbon molecules from renewable biomass: Provided is a process for producing hydrocarbon molecules from biomass utilizing microorganisms that are resistant to extreme heat and pressure, that comprise nucleic acid molecules encoding enzymes which degrade compounds selected from the group consisting of cellulose, lignin, xylan and hemicellulose, and which are capable of generating hydrocarbon molecules from... Agent: Hunton & Williams/new York Intellectual Property Dept.
20090017514 - Membrane supported bioreactor for conversion of syngas components to liquid products: Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO2 and H2 with a surface of a membrane under anaerobic conditions and transferring these components in contact with a biofilm on the opposite side of the membrane. These steps provide a... Agent: Cardinal Law Group
20090017515 - Process for microbial production of a valuable compound: The present invention relates to a process for the production of a valuable compound by cultivation of a microorganism comprising cultivating the microorganism in a medium wherein all nutrients are provided in excess over the whole cultivation period and wherein a suitable amount of oxygen is fed to the culture... Agent: Nixon & Vanderhye, PC
20090017516 - Target physiological function inactivator using photosensitizer-labeled fluorescent protein: An object of the present invention is to provide a method of generating reactive oxygen species in a light irradiation-dependent manner, so as to inactivate any target physiological function. The present invention provides a target physiological function inactivator which consists of a photosensitizer-labeled fluorescent protein, wherein fluorescence resonance energy transfer... Agent: Greenblum & Bernstein, P.L.C
20090017517 - Preparation of negative-stranded rna viruses by electroporation: The present invention encompasses methods of preparing non-segmented negative-stranded RNA viruses from cells utilizing electroporation.... Agent: Medimmune, LLC Jonathan Klein-evans
20090017518 - Magnetic particles and fabrication method thereof: A magnetic particle and fabrication method thereof. The magnetic particle comprises a polymer core, a magnetic material layer covering the polymer core, and a silicon containing layer covering the magnetic material layer. In addition, the magnetic particle may further comprise a coupling agent on the silicon containing layer, and an... Agent: Birch Stewart Kolasch & Birch
20090017519 - Enzyme preparations for use as biocatalysts: The invention is directed to enzyme preparations which are obtainable by enzyme immobilizates which comprise enzymes or microorganisms containing enzymes immobilized on an inert carrier being provided with a silicone coating obtained by hydrosilylation, to a process for producing such enzyme preparations and to the use of enzyme preparations as... Agent: Frommer Lawrence & Haug
20090017520 - Process and materials for production of glucosamine: The present invention relates to a method and materials for producing glucosamine by fermentation of a genetically modified microorganism. Included in the present invention are genetically modified microorganisms useful in the present method for producing glucosamine, as well as recombinant nucleic acid molecules and the proteins produces by such recombinant... Agent: Sheridan Ross PC
20090017521 - Chimaeric phages: The invention relates to the field of generating helper phages and phage display libraries for the identification of binding molecules. The invention provide chimaeric phages having a coat comprising a protein mixture. The protein mixture comprises a fusion protein having a proteinaceous molecule fused to a functional form of a... Agent: Trask Britt
20090017522 - Polynucleotides encoding promyostatin polypeptides: The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can specifically hybridize to such polynucleotides. The present invention also provides an isolated polynucleotide encoding a mature myostatin peptide.... Agent: Dla Piper LLP (us)
20090017523 - Virus purification methods: Provided is a method for purifying a virus from a host cell, the method comprising: a) culturing host cells, b) infecting the host cells with a virus, c) treating the cell culture with nuclease, and d) lysing the host cells to provide a lysate comprising the virus. The virus may... Agent: Trask Britt
20090017524 - Product for the treatment of wastewaters and sewage: Biodegradable support carrying a mixture of non-pathogenic bacteria that synergistically cooperate in decomposing the organic pollutants present in toilet wastewaters and in sewage collection and processing tanks.... Agent: Arent Fox LLP
20090017525 - S-triazine-herbicide-degrading bacteria, product for the bioremediation and method of bioremediation: The present invention provides a bacterial strain which is able to degrade or mineralize s-triazine compounds, such as simazine, which corresponds to Pseudomonas sp. strain MHP41, deposited under the accession number NRRL B-30908. The present invention provides a product for the bioremediation of environments contaminated with s-triazine, where the product... Agent: Merchant & Gould PC
20090017526 - Method of using endophytic fungi to decontaminate and decompose human and animal wastes: A method of treating human and/or animal waste products comprising contacting the waste products with an effective amount of Fusarium culmorum and Muscodor albus, together with a buffering agent and starch. The treatment process covered by the present invention can be employed in connection with pit toilets, portal a toilets,... Agent: Antoinette M. Tease
20090017527 - Advanced genetic vaccines: Reagents useful in nucleic acid immunization techniques are described. More particularly, adjuvanted genetic vaccine compositions are described, as are methods of using those compositions for inducing an enhanced immune response against a selected antigen.... Agent: Foley And Lardner LLP Suite 500
20090017528 - Nucleic acid hybridization device: The present invention relates to a hybridization device coupled by means of vibration to shorten the time needed for hybridization. This hybridization device of the present invention comprises an oscillation generating unit; a spacer attached to the top of the oscillation generating unit, which wraps around to form a tank,... Agent: Wpat, PC Intellectual Property Attorneys
20090017529 - Scalable wall bioreactor for culture of plant and animal tissues: A flexible wall bioreactor is described that uses a small droplet size mist unit, a lower rate ambient air flow rate, and a flexible wall culture chamber to provide an environment that allows for the growth of dense root matrix, shoot cultures, and 2 and 3 dimensional animal tissues.... Agent: Burns & Levinson, LLP
20090017531 - Method for isolating plasmids from suspended bacterial or yeast cells: A method for isolating plasmids from suspended bacterial or yeast cells using a filter matrix, at least one lysing substance being added to the suspension and predamaging or completely lysing the predominant portion of the suspended cells, at least one conformation-altering substance being added to the suspension to alter the... Agent: Rankin, Hill & Clark LLP
20090017532 - Vector: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.... Agent: Marshall, Gerstein & Borun LLP
20090017530 - Viral vectors whose replication and, optionally, passenger gene are controlled by a gene switch activated by heat in the presence or absence of a small-molecule regulator: The present invention relates to conditionally replicating viruses or pairs of viruses containing a gene switch that is activatable by transient heat or other proteotoxic stress in the presence or absence of a small molecule regulator. The gene switch controls the expression of a gene for a protein required for... Agent: Voellmy, Richard
20090017533 - Optimized messenger rna: The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common... Agent: Lowrie, Lando & Anastasi, LLP
20090017534 - Slo2 and slo4, novel potassium channel proteins from human brain: The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods... Agent: Townsend And Townsend And Crew, LLP
20090017535 - Modified green fluorescent proteins and methods for using same: The present invention provides nucleic acid molecules encoding mutant fluorescent proteins as well as proteins encoded by these nucleic acids. In addition, host-cells, stable cell lines and transgenic organisms comprising the above-referenced nucleic acid molecules are provided. The subject protein and nucleic acid compositions find use in a variety of... Agent: Patterson & Sheridan, L.L.P.
20090017536 - Modified vaccinia ankara virus variant and cultivation method: The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and the use of the virus, or its recombinants, as a... Agent: Law Office Of Salvatore Arrigo
20090017537 - Ht2r54 receptor polypeptides and nucleic acid sequences: Functional assays that detect the effect of a particular compound or compounds on the activation of at least one human T2R polypeptide are provided. These assays include e.g., assays which detect the effect of said compound on intracellular calcium, second messengers such as cAMP, cGMP, current e.g., by use of... Agent: Hunton & Williams LLP Intellectual Property Department
20090017538 - Mammalian mdm2 binding proteins and uses thereof: Isolated nucleic acid sequences encoding mammalian binding protein and polypeptide sequences for the mammalian MDM2 binding protein are provided. Also provided are vectors containing these nucleic acid sequences, host cells which express these proteins and antibodies targeted to these proteins. In addition, methods and compositions for modulating the G1 phase... Agent: Licata & Tyrrell P.C.
20090017539 - Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics: The invention provides means and methods for stem cell proliferation and subsequent generation and expansion of progenitor cells. The invention in particular provides media and other culture conditions for the same. The cells are preferably used as effector cells as clinical therapeutics.... Agent: Hoffmann & Baron, LLP
20090017540 - Method of culturing cells under regulation in the extension direction: [Means for Solving Problems]A cell culture plate having a plural number of side walls (1) and a plural number of space structures (3) for providing cultured cells which are formed by the side walls (1), wherein the side walls (1) are provided with openings (2) so that the space structures... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090017541 - Porous sheet-form material for cell culture, and bioreactor and culturing method utilizing same: The present invention provides a bioreactor having a system that can grow cells, tissue, etc. while maintaining or improving their function, and finally recover the cells as they are with good efficiency. The bioreactor has a porous sheet-form material disposed in its main body, the porous sheet-form material being formed... Agent: Sughrue Mion, PLLC
20090017542 - High-efficiency wild-type-free aav helper functions: The present invention provides methods and compositions for producing high titer, wild-type-free preparations of recombinant AAV (“rAAV”) virions. The compositions of the present invention include novel nucleic acids encoding AAV helper functions and AAV helper function vectors. The present invention also includes host cells transfected by the claimed nucleic acids,... Agent: Robins & Pasternak
20090017543 - Viral vectors: The present invention relates to an integration defective retroviral vector particle for gene therapy comprising a viral genome, wherein said vector particle is capable of infecting a mammalian target cell.... Agent: Frommer Lawrence & Haug01/08/2009 > patent applications in patent subcategories. recently filed with US Patent Office
20090011399 - Method and apparatus for biopsy sample processing: A container for use in processing a biopsy sample. Biopsy sample and materials are received within a sample processing area of the container. A semi-permeable barrier is positioned at a downstream portion of the sample processing area and prevents the prevent passage of the biopsy sample. A cap is positioned... Agent: Wolf Greenfield & Sacks, P.C.
20090011401 - Group of reagent carriers that is combined to form a composite: The invention concerns a group of reagent carriers that is combined to form a composite, each one of said carriers having at least one test region located in a shallow trough-like depression, where the reagent carriers in the composite are held together exclusively by interconnected protective covers for the test... Agent: Dinsmore & Shohl, LLP One Dayton Centre
20090011400 - Substrate switched ammonia lyases and mutases: Crystal structure information is used to make substrate-switched amino acid ammonia lyase enzymes, including TALs, PALs and HALs. Related methods, systems, compositions, cells and transgenic organisms are provided.... Agent: Quine Intellectual Property Law Group, P.C.
20090011402 - Biosensors based on directed assembly of particles: A sensor system for detecting an effector or cofactor comprises (a) a nucleic acid enzyme; (b) a substrate for the nucleic acid enzyme, comprising a first polynucleotide; (c) a first set of particles comprising a second polynucleotide at least partially complementary to the substrate, where the polynucleotide is attached to... Agent: Evan Law Group LLC
20090011403 - Microporous materials, methods of making, using, and articles thereof: Described herein are methods for separating one or more analytes present in a fluid sample. The methods involve passing the fluid through or into a microporous material, wherein the analytes are localized near the surface of the microporous material. Additional processing steps such as hybridization and amplification can be performed... Agent: Ballard Spahr Andrews & Ingersoll, LLP
20090011409 - Antibodies against cells of fetal origin: This invention relates to antibodies that specific bind to fetal CD36+ cells in preference to binding to maternal CD36+ cells and methods for using these antibodies to detect and separate fetal cells from adult biological fluids including maternal peripheral blood.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090011424 - Cancer-suppressing agents: It is an object of the present invention to provide a cancer-suppressing agent comprising a novel cancer-suppressing gene based on the discovery of such cancer-suppressing gene. The present invention provides a cancer-suppressing agent which comprises NR1I2 gene or a homologous gene thereof; and a cancer-suppressing agent which comprises NR1I2 protein... Agent: Birch Stewart Kolasch & Birch
20090011418 - Functional toll-like receptors (tlr) on melanocytes and melanoma cells and uses thereof: The invention relates to a method of detecting Toll-like receptor (TLR) gene expression or protein activity in a melanocyte or melanoma cell. Also disclosed are a method of modulating TLR gene expression or protein activity in a melanocyte or melanoma cell by contacting the cell with a TLR modulating agent... Agent: Hogan & Hartson L.L.P.
20090011423 - Genes for prognosis of cancer: To provide a novel method for determining the risk of lymph node metastasis of breast cancer uses as an index the difference in the expression levels of marker genes between metastatic breast cancer tissue (or cell) and non-metastatic breast cancer tissue (or cell). The method involves (1) measuring the expression... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20090011412 - Hip1 cancer markers: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, HIP1 cancer markers. In particular, the present invention provides compositions and methods of using HIP1 in the diagnosis and treatment of lymphoma and brain cancers.... Agent: Casimir Jones, S.c.
20090011414 - Human autism susceptibility gene encoding a kinase and uses thereof: The present invention discloses the identification of a human autism susceptibility gene, which can be used for the diagnosis, prevention and treatment of autism and related disorders, as well as for the screening of therapeutically active drugs. The invention more specifically discloses that the MARK1 gene on chromosome 1 and... Agent: Occhiuti Rohlicek & Tsao, LLP
20090011411 - Method for detecting and quantifying endogenous wheat dna sequence: It is an object of the present invention to provide partial sequences of endogenous wheat DNA (genome) which are single copies and which allow wheat to be specifically detected without cross-reacting with other plants in PCR, and to provide primers for amplifying these partial sequences, along with a good method... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20090011413 - Method for screening colon cancer cells and gene set used for examination of colon cancer: Colon cancer cells in a sample are screened by analyzing the amount of expression of at least 2 or more genes or products thereof selected from the group of genes listed in Tables 1 and 30. As compared to conventional method, patients having colon cancer can be detected with higher... Agent: Fitzpatrick Cella Harper & Scinto
20090011410 - Method for tailoring administration of drugs by quantitation of mrna: The present invention discloses a method for tailoring drug protocols to individual patients based on the levels of marker mRNA measured in leukocytes after stimulation of whole blood of the patient with candidate drugs. A method of measuring a patient's responsiveness to a drug is disclosed that includes exposing whole... Agent: Knobbe Martens Olson & Bear LLP
20090011406 - Method of judging fatigue: A method of judging fatigue, which comprises judging fatigue by using, as an index, a value obtained by quantitatively analyzing an adenine nucleotide in a sample to be measured.... Agent: Greenblum & Bernstein, P.L.C
20090011422 - Methods for cloning small rna species: This invention pertains to methods for cloning microRNA (miRNA) and other small ribonucleic acid (RNA) species from relevant cell sources.... Agent: John Petravich Integrated Dna Technologies, Inc.
20090011408 - Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase: The invention relates to and methods for generating a signal indicative of the presence of a target nucleic acid in a sample. The compositions and methods include a reverse transcriptase, a nuclease, an upstream primer and downstream probe.... Agent: Agilent Techologies Inc
20090011405 - Modulating screening thresholds for n-hybrid screening: The present invention provides improved N-hybrid assays. In particular, the present invention provides an improved reverse N-hybrid assay comprising modulating the amount of a substrate of a reporter gene and/or the amount of a reporter gene thereby enhancing cell death in the absence of a peptide inhibitor of a DNA-protein... Agent: Knobbe Martens Olson & Bear LLP
20090011407 - Polymorphic cd24 genotypes that are predictive of multiple sclerosis risk and progression: An image data correction apparatus has a motion information acquisition section, a correction section, and a composition section. The motion information acquisition section acquires motion information indicating spatial distribution of the magnitude of motion, in actual space, of a to-be-imaged portion of a subject. Based on the motion information, the... Agent: Calfee Halter & Griswold, LLP
20090011419 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto
20090011416 - Random array dna analysis by hybridization: The invention relates to methods and devices for analyzing single molecules, i.e. nucleic acids. Such single molecules may be derived from natural samples, such as cells, tissues, soil, air and water without separating or enriching individual components. In certain aspects of the invention, the methods and devices are useful in... Agent: Morgan, Lewis & Bockius, LLP
20090011415 - Regulation of neuronal expression of apolipoprotein e: The present invention provides nucleic acids comprising a nucleotide sequence encoding an apolipoprotein E (apoE) splice variant, e.g., an unprocessed apoE, that retains intron 3; and vectors and host cells comprising same. The present invention further provides screening methods to identify agents that inhibit cleavage of intron-3 from the apoE... Agent: Bozicevic, Field & Francis LLP
20090011420 - Sparsely cross-linked nanogels: a novel polymer structure for microchannel dna sequencing: The present invention is generally directed to novel polymeric materials for use in the electrophoretic separation of nucleic acids. In particular, the novel polymer materials are sparsely crosslinked nanogels, dissolved in an aqueous buffer to form solutions with moderate to high viscosity. The present invention further provides methods for generating... Agent: Casimir Jones, S.c.
20090011421 - Susceptibility to bone damage: In one aspect, the present invention provides methods for determining susceptibility to bone damage in a subject. In some embodiments, the methods comprise screening for polymorphisms in the MTHFR and collagen Iα1 genes that are associated with susceptibility to bone damage. In some embodiments, the methods comprise screening for elevated... Agent: Sheridan Ross PC
20090011417 - Testing device: The invention provides, in different aspects, a system, sample preparation device, sample processing cartridge, kit, methods of use, business methods, and computer program product.... Agent: Wilson Sonsini Goodrich & Rosati
20090011427 - Assays for preimplantation factor and preimplantation factor peptides: The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently... Agent: Pepper Hamilton LLP
20090011429 - Diagnosis of pre-eclampsia: The present invention relates to a method of predicting pre-eclampsia (PE). The present invention also relates to a diagnostic kit for performing a method of predicting PE. In particular, the method determining the level of two or more markers selected from placenta growth factor (P1GF), plasminogen activator inhibitor-1 (PAI-1), plasminogen... Agent: Banner & Witcoff, Ltd.
20090011428 - Fluid membrane-based ligand display system for live cell assays and disease diagnosis applications: A supported membrane based, strategy for the presentation of soluble signaling molecules to living cells is described. In this system, the fluidity of the supported membrane enables localized enrichment of ligand density in a configuration reflecting cognate receptor distribution on the cell surface. Display of a ligand in non-fluid supported... Agent: Lawrence Berkeley National Laboratory
20090011425 - Incubation device for serology and histology slides: This application relates to an incubation device for serology or histology supports. It also relates to any apparatus comprising one such device, and to the use of said apparatuses and/or devices in analysis or diagnosis methods.... Agent: Heslin Rothenberg Farley & Mesiti PC
20090011426 - Methods of diagnosis and treatment of m.tuberculosis infection and reagents therefor: The present invention provides diagnostic, prognostic and therapeutic reagents for infection of an animal subject such as a human by M. tuberculosis, and conditions associated with such infections, such as, for example, tuberculosis. More particularly, the present invention provides a recombinant protein of M. tuberculosis designated “BSX” (SEQ ID NO:... Agent: Cozen O'connor, P.C.
20090011430 - Electrical detection using confined fluids: A device having: a laminar flow channel for liquids; two or more electrodes; a confining fluid inlet; a sample inlet; and a meter for measuring the impedance of any fluid between the electrodes. The device may have one or more specific binding sites, or it may have sheathing and unsheathing... Agent: Naval Research Laboratory Associate Counsel (patents)
20090011437 - Methods of detecting antibodies specific for denatured hla antigens: The invention is directed to methods of screening for HLA antibodies comprising detecting antibodies specific for native HLA antigens and denatured HLA antigens. The invention also provides for method of predicting whether a transplant recipient has an increased risk for rejecting the transplanted organ.... Agent: Marshall, Gerstein & Borun LLP
20090011438 - Collagen vi and cancer: Methods of determining whether a cancer is progressing by measuring surface-bound collagen VIα3 are provided. Also provided are methods of identifying hyperplasia in a tissue by measuring surface-bound collagen VIα3. Additionally, methods of identifying carcinoma in a tissue by measuring surface-bound collagen VIα3 are provided. Further provided are methods of... Agent: Craig J. Arnold, Esq. Amster, Rothstein & Ebenstein LLP
20090011441 - Novel methods of cancer diagnosis and therapy targeted against a cancer stem line: Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.... Agent: Jones Day
20090011439 - Prognosis and therapy predictive markers and methods of use: Disclosed is a set of genes differentially expressed in chemotherapy and radiation resistant tumors useful in predicting response to therapy and assessing risk of local-regional failure, survival and metastasis in cancer patients. Also disclosed are methods for characterizing tumors according to gene expression and kits for use in the methods... Agent: Michael Best & Friedrich LLP
20090011440 - Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy: The invention provides a method for determining the activation status of receptor tyrosine kinase (RTK) pathways in either cell samples or patient samples by measuring receptor dimerization and relative amounts of protein-protein complexes or activated effector proteins that are characteristic of an RTK pathway. The invention also provides a method... Agent: Monogram/fenwick
20090011442 - Tb diagnostics based on mycobacterium tuberculosis excretory secretory antigens and their specific immunoglobulins: The present invention relates to isolation and identification of novel M. tuberculosis excretory secretory antigen proteins released in vitro/in vivo, raising the specific immunoglobulins and their use as diagnostic reagents for tuberculosis. The invention further relates to a combination of antigens and immunoglobulins for effective detection and immunomonitoring of pulmonary... Agent: Dr. Harinath C. Bhaskar
20090011432 - Detecting and profiling molecular complexes: Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first protein in a complex and one or more binding compounds specific for one or more second proteins... Agent: Monogram/fenwick
20090011431 - Diagnosis of sepsis by the selective determination of the concentration of cu/zn superoxide dismutase (cu/zn sod) in patient samples: The present invention relates to a method for the early determination of the risk of mortality of patients in intensive care units or emergency care units during which the concentration of Cu/Zn superoxide dismutase (Cu/Zn SOD) in a serum sample or plasma sample of the patient is selectively determined, and... Agent: Heslin Rothenberg Farley & Mesiti PC
20090011433 - Recombinant biotin carboxylase domains for identification of acetyl coa carboxylase inhibitors: A peptide comprising an Acetyl CoA carboxylase (ACCase) having a deleted biotin binding domain, having a deleted carboxy transferase domain, and having a functional biotin carboxylase (BC) domain is described. A nucleic acid that encodes the peptide described above and a recombinant host cell that contains the nucleic acid and... Agent: Myers Bigel Sibley & Sajovec
20090011435 - Assays for detecting antibodies to therapeutics: The disclosed invention relates to methods and devices for detecting a biologic in a test sample. In particular, the disclosed assay utilizes EPO as a target to detect endogenous anti-EPO antibodies in a sample and does not manipulate or modify the target EPO antibody.... Agent: Morrison & Foerster LLP
20090011434 - Methods and compositions for diagnosing breast cancer: Mammastatin has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and 49 kDa. Metastatic mammary cells either do not express Mammastatin at all, or do not express the 53 kDa or 49... Agent: Casimir Jones, S.c.
20090011444 - Detection and diagnosis of inflammatory disorders: Soluble H4 (sH4) levels have been discovered to correlate with the stage or severity of inflammatory disorders including autoimmune disorders. In particular, circulating levels of sH4 can be used as a diagnostic for determining the severity of an inflammatory disorder or the propensity for developing an inflammatory disorder. The severity... Agent: Patrea L. Pabst Pabst Patent Group LLP
20090011445 - Method and apparatus for in vivo collection of circulating biological components: The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of... Agent: Knobbe Martens Olson & Bear LLP
20090011443 - Methods for simultaneously detecting both members of a binding pair: Methods and kits for simultaneously measuring both members of a binding pair are described.... Agent: Fish & Richardson P.C.
20090011446 - Colony assay miniaturization with enumeration output: A system combining a clonogenic differentiation assay with an instrument-based ATP bioluminescence proliferation assay to produce a standardized colony-forming stem and progenitor cell potency assay is provided.... Agent: Rosenbaum & Associates, P.C.
20090011448 - Pretreatment agent for limulus test: A pretreatment agent for a sample to be subjected to Limulus assay comprising an alkali metal sulfate and/or an alkaline earth metal sulfate wherein the sulfate(s) has a final concentration of 20 mM or more when the sulfate(s) is allowed to contact with the sample, or an alkali metal halide... Agent: Sughrue-265550
20090011447 - Quantification of vitellogenin: The present invention is directed to a simple method for absolute quantification of plasma vitellogenin from two or more different fish species such as Rainbow trout and Atlantic salmon, or Atlantic cod and haddock. In the case of Rainbow trout and Atlantic salmon, plasma samples obtained from control and β-estradiol... Agent: The Farrell Law Firm, P.C.
20090011449 - No calibration analyte sensors and methods: A meter and sensors, for use in combination, where no calibration code has to be entered by the user or is read by the meter. The meter is configured with a predetermined slope and y-intercept built into the meter. If the slope and y-intercept of the sensor are within a... Agent: Bozicevic, Field & Francis LLP
20090011450 - Dry analytical element for lipase measurement: It is an object of the present invention to provide a dry analytical element for pancreatic lipase analysis having high selectivity with respect to pancreatic lipase, whose multianalyte correlation has been improved. The present invention provides a dry analytical element for measurement of pancreatic lipase contained in a body fluid,... Agent: Birch Stewart Kolasch & Birch
20090011455 - Disease model incorporation into an artificial immune system (ais): The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the tissues of the immune system in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates and... Agent: Merchant & Gould PC
20090011454 - Fluorescent sensors for cellular amines: The invention provides compounds of formulas I, II, and III, methods of making them, and methods of their use. The compounds of the invention can be used as fluorescent sensors, for example, to detect an amine-containing analyte in a biological sample. The compounds can be selective for one type of... Agent: Schwegman, Lundberg & Woessner, P.A.
20090011452 - Method of prognosis of mental diseases, e.g. autism and cerebral palsy: The invention provides a method of prognosis for applied behavioral analysis treatment of mental disease, in particular autism or cerebral palsy, in a human subject. The method includes analyzing a sample of body tissue or fluid from the subject for the presence or absence of a chemical marker indicative of... Agent: Knobbe Martens Olson & Bear LLP
20090011453 - Methods for producing proteins using hamster igf-1: A polypeptide selected from the group consisting of: (1) a polypeptide having the amino acid sequence of SEQ ID NO: 1, and (2) a polypeptide having an amino acid sequence in which the third amino acid of the amino acid sequence of SEQ ID NO: 1 is substituted by another... Agent: Foley And Lardner LLP Suite 500
20090011456 - Methods for the diagnosis and prognosis of graft versus host disease by measurement of peripheral cd3+cd4+cd8beta+ cells: Acute graft versus host disease (GvHD) is one of the most significant clinical problems in allogeneic blood and marrow transplantation. Currently, there is no unequivocal diagnostic test for GvHD until the disease is well developed and can be recognized histologically. The invention provides a blood based test for diagnosis and/or... Agent: Borden Ladner Gervais LLP Anne Kinsman
20090011451 - Microfluidic device and leucocyte antigen mediated microfluidic assay: The present invention relates to an leucocyte antigen mediated microfluidic assay and a microfluidic device for analyzing a subjects' body fluids containing leucocytes to determine if the subject has been previously exposed to a predetermined antigen.... Agent: Passe' Intellectual Property, LLC
20090011457 - Method and device for testing the bactericidal effect of substances: The method for checking the degree of microbial loading of laundry after a wash cycle is characterized in that a defined amount of living microorganisms are washed together with the laundry, in that the number of microorganisms still living after the end of the wash process is determined and in... Agent: Moetteli & Associates Sarl
20090011458 - Method for selectively staining microorganisms: A method for selectively flagging target microorganisms in a liquid sample also including background particles comprises the steps of adding a lysing agent selected to breach the background particles to the sample, adding a dye selected to flag the target microorganisms to the sample, adding a suppressing agent selected to... Agent: Jennifer L. Bales
20090011460 - Calcium-binding photoprotein, gene encoding the same, and use thereof: A protein according to the invention can be used to detect or measure calcium ions is provided. Further the protein is useful as a reporter protein or a luminescence marker. A polynucleotide according to the invention is also useful as a reporter gene.... Agent: Hogan & Hartson LLPIPGroup, Columbia Square
20090011461 - Human spasmolytic polypeptide in glycosylated form: p
20090011462 - Polypeptides having lipase activity and polynucleotides encoding same: The present invention relates to polypeptide having lipase activity and which further has a RP of at least 0.8 and a BR of at least 1.1 at the test conditions given in the specification.... Agent: Novozymes North America, Inc.
20090011463 - Pcka modifications and enhanced protein expression in bacillus: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins, wherein the pckA gene has been modified or deleted. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein... Agent: Genencor International, Inc. Attention: Legal Department
20090011465 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department
20090011466 - Concatameric immunoadhesion molecule: Disclosed are concatameric proteins comprising two soluble domains, in which the C-terminus of a soluble domain of a biologically active protein is linked to the N-terminus of an identical soluble domain or a distinct soluble domain of a biologically active protein. Also, the present invention discloses dimeric proteins formed by... Agent: Greenblum & Bernstein, P.L.C
20090011464 - Humanized immunoglubulin reactive with alph4beta7 integrin: The present invention relates to isolated nucleic acids encoding humanized immunoglobulins having binding specificity for α4β7 integrin, isolated nucleic acids encoding a humanized immunoglobulin heavy chain and isolated nucleic acids encoding a humanized light chain having binding specificity for α4β7 integrin. The invention also relates to expression vectors and host... Agent: Mcdermott Will & Emery LLP
20090011468 - Method for improving protein production: The present invention relates to the production of proteins in a cell or host cell. The invention uses a TRAnscription Pause (TRAP) sequence to enhance a protein expression characteristic of a protein expression unit. The TRAP sequence is thought to prevent, at least in part, formation of antisense RNA or... Agent: Trask Britt
20090011467 - Novel fructosyl peptide oxidase: A novel fructosyl peptide oxidase having physicochemical properties useful as an enzyme for clinical diagnosis, and a method for producing a novel fructosyl peptide oxidase are provided herein, the method comprising: culturing a microorganism capable of producing the oxidase in a medium; and collecting the oxidase from the culture. Furthermore,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090011469 - Method and formulation for the extraction of nucleic acids from any complex starting materials: The invention relates to a universal and greatly simplified method as well as a composition for isolating nucleic acids from different starting materials containing nucleic acids. The composition contains at least one buffer solution for proteolytically solubilizing biological samples, the buffer containing no chaotropic or antichaotropic component, at least one... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090011470 - Nucleic acid sample preparation by exclusion of dna: Devices and methods are provided for separation of nucleic acids from waste materials in a biological sample, and then reacting the separated nucleic acids. In some embodiments, the methods comprise mixing a cell lysate having nucleic acids and waste materials with a waste-binding matrix to capture the cellular waste materials... Agent: Kilyk & Bowersox, P.l.l.c.
20090011471 - Engineered plasmids and their use for in situ production of genes: Nucleic acid sequences encoding at least a portion of a polypeptide are directly incorporated into a plasmid by DNA polymerization or reverse transcription of a nucleic acid template. In particularly preferred embodiments, nucleic acid sequences encoding at least a portion of an antibody are directly incorporated into a plasmid by... Agent: Ropes & Gray LLP
20090011472 - Isothermal dna amplification: Provided herein are nucleic acid synthesis methods and agents that employ an endonuclease for example, endonuclease V, to introduce a nick into a target DNA including one or more inosine, and uses a DNA polymerase to generate amplicons of the target DNA.... Agent: General Electric Company Global Research
20090011474 - Process for producing sugars from cellulosic biomass: A process for increasing production of sugars from cellulose in a plant biomass using ammonia after swelling of the biomass with water and enzymatic hydrolysis is described. The sugars are preferably fermented to an alcohol, particularly ethanol as a fuel for vehicles.... Agent: Ian C. Mcleod, P.C.
20090011473 - Saccharifying cellulose: Dissolution, partial dissolution or softening of cellulose in an ionic liquid (IL) and its subsequent contact with anti-solvent produces regenerated cellulose more amorphous in structure than native cellulose, which can be separated from the IL/anti-solvent mixture by mechanical means such as simple filtration or centrifugation. This altered morphology of IL-treated... Agent: Emch, Schaffer, Schaub & Porcello Co
20090011404 - Methods and compositions for optical detection of single-stranded polynucleotides: The invention relates to products and methods for determining, localizing, and quantitating single-stranded polynucleotides. The methods of the invention include the use of Gp32F protein and mutant Gp32F protein to monitor polynucleotide reactions such as DNA replication, annealing, and excision and to determine single-stranded polynucleotide structures such as gaps, flaps,... Agent: Wolf Greenfield & Sacks, P.C.
20090011476 - Gene cluster and method for the biosynthesis of terrequinone a: The present invention provides a novel gene cluster containing five genes (tdiA-E) involved in indole alkaloid synthesis. Disruption of tdiB, encoding an enzyme with prenyltransferase activity, transferring dimethylallylpyrophosphate to C-2 of an indole structure, eliminated the production of the antitumor compound terrequinone A, a metabolite not known from A. nidulans.... Agent: Quarles & Brady LLP
20090011477 - Stability of secondary metabolite mass production through synchronized plant cell cultures: This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from the procambium to promote the stability of the plant-derived biologically active substances production by solving... Agent: Moore & Van Allen PLLC
20090011478 - Biochemical synthesis of 1,4-butanediamine: The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as compared to the native level of the ornithine decarboxylase activity, wherein in the microorganism also an increased activity of N-acetylglutamate formation is present... Agent: Nixon & Vanderhye, PC
20090011479 - Biotransformation of colchicinoid compounds: The present invention relates to a biotransformation process, effected by means of selected microbial strains, for the preparation of 3-O-glycosyl derivatives of colchicinoid compounds.... Agent: Ladas & Parry LLP
20090011480 - Use of cellulosic materials for cultivation of microorganisms: The invention provides methods of cultivating oil-bearing microbes using cellulosic material. Also provided are microorganisms that manufacture non-alcohol-based fuels and fuel feedstocks through a process of converting cellulosic materials into oils. Also provided are compositions comprising depolymerized cellulosic materials and oil-bearing microbes. Some methods of microbial fermentation are provided that... Agent: Townsend And Townsend And Crew, LLP
20090011481 - Process for fermenting sugars containing oligomeric saccharides: Sugar mixtures containing nonfermentable oligomers are fermented in the presence of certain enzymes that depolymerise the oligomers simultaneously with the fermentation process.... Agent: Gary C. Cohn, PLLC
20090011482 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP
20090011483 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP
20090011484 - Concurrent saccharification and fermentation of fibrous biomass: A process for simultaneous saccharification and fermentation of a cellulosic solids fraction extracted from a lignocellulosic feedstock. The viscosity of the cellulosic solids fraction is reduced by intermixing with a liquid carbohydrate stream. A suitable liquid carbohydrate stream is a de-lignified liquids fraction that was previously separated from the solids... Agent: Fasken Martineau Dumoulin, LLP
20090011485 - Method of retrovirus storage: A method of retrovirus storage, characterized in that a retrovirus is sustained in the presence of a substance with retrovirus binding activity immobilized on a solid phase. Further, there is provided a retrovirus composition characterized in that a retrovirus in the form of binding to a substance with retrovirus binding... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20090011486 - Biodegradable elastomers: The present inventions in various aspects provide elastic polymers compositions for encapsulation of cells. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked in the presence of glycerol and... Agent: Choate, Hall & Stewart LLP
20090011488 - Methods for storing compositions useful for synthesizing nucleic acid molecules: In one aspect, the present invention provides methods for storing a composition useful for synthesizing nucleic acid molecules. The methods of this aspect of the invention include the steps of: (a) freezing multiple aliquots of a liquid composition comprising from 1000 units/mL to 5000 units/mL of a reverse transcriptase, or... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20090011487 - Production of ugppase: What are disclosed are a purified novel enzyme protein, UGPPase, which naturally occurs in animal cells, its production by means of recombinant technology, an antibody to the enzyme protein, a method of carrying out ELISA for measurement of the amount of UGPPase in an analyte and a method for determination... Agent: Millen, White, Zelano & Branigan, P.C.
20090011489 - Multiply-substituted protease variants: Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino... Agent: Genencor International, Inc. Attention: Legal Department
20090011490 - Immunogenic minicells and methods of use: The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.... Agent: Knobbe Martens Olson & Bear LLP
20090011491 - Culture media for increasing biopesticide producing microorganism's pesticidal activity, methods of producing same, biopesticide producing microorganisms so produced: A media for growing a biopesticide producing microorganism comprising waste water sludge having undergone thermal alkaline hydrolysis performed by adjusting the pH of the wastewater sludge between about 8 and about 12 with an alkaline solution selected from the group consisting of NaOH, KOH, CaOH2 and MgOH2 at a temperature... Agent: Kevin M. Farrell Pierce Atwood LLP
20090011492 - Photobioreactor cell culture systems, methods for preconditioning photosynthetic organisms, and cultures of photosynthetic organisms produced thereby: Certain embodiments of the invention involve methods and systems for preselecting, adapting, and preconditioning one or more species of photosynthetic organisms, such as algae, to specific environmental and/ or operating conditions to which the photosynthetic organisms will subsequently be exposed during utilization in a photobioreactor apparatus of a gas treatment... Agent: Wolf Greenfield & Sacks, P.C.
20090011493 - Device containing cytophilic islands that adhere cells separated by cytophobic regions: The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The... Agent: Wolf Greenfield & Sacks, P.C.
20090011494 - Method for controlling biological function with mechanical vibration and device therefor: Methods and apparatus for controlling biological functions with mechanical vibration are provided. Stimulation is applied to cells of one of an organism, bacteria or virus by mechanical vibration. The biological function comprises biological functions relating to cell growth. The biological functions relating to cell growth may include at least one... Agent: Lipsitz & Mcallister, LLC
20090011495 - Incubator apparatus and method: The present invention relates to a method of processing analyte using a portable incubator apparatus. The incubator apparatus 10 has a plurality of cavities 20 each configured to receive analyte to be incubated. The method comprises: receiving analyte in each of the plurality of cavities; incubating the analyte in the... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group
20090011498 - Expansion of nk cells and therapeutic uses thereof: The present invention relates to novel methods for preferentially activating and expanding NK cells. The methods utilize the stimulatory effects of IL-15 and CD137 ligand to preferentially expand and activate NK cells in a mixed cell culture comprising NK cells.... Agent: Alston And Bird LLP St. Jude Children's Research Hospital
20090011497 - Peptides and related compounds having thrombopoietic activity: The present invention relates generally to novel peptides and related compounds that have thrombopoietic activity. The compounds of the invention may be used to increase production of platelets or platelet precursors (e.g. megakaryocytes) in a mammal.... Agent: Amgen Inc.
20090011496 - Enhancement of mammalian embryo development: A method of enhancing in vitro development of a mammalian embryo is disclosed which comprises supplementing the culture medium with a prostaglandin, or a prostaglandin analog, in an amount effective to promote complete hatching of the embryo (i.e., freeing of the embryo from the zona pellucida). The quality of human... Agent: Conley Rose, P.C. David A. Rose
20090011499 - Antibodies that bind ldcam: The invention is directed to LDCAM as a purified and isolated protein, the DNA encoding the LDCAM, host cells transfected with cDNAs encoding LDCAM, processes for preparing LDCAM polypeptides and compositions and methods for treating utilizing LDCAM polypeptides.... Agent: Immunex Corporation Law Department
20090011500 - G+c rich binding protein: A novel transcription regulator of G+C-rich promoters, the murine G+C-rich Promoter Binding Protein (mGPBP), and its interaction pattern with other transcription factors are disclosed. A human homologue of mGPBP, hGPBP, is described as well.... Agent: Howrey LLP - Dc
20090011501 - Novel death domain proteins: In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules encoding DD, DED and NB-ARC domain proteins, vectors containing these nucleic acid molecules and host cells containing the vectors. The invention also... Agent: Mcdermott, Will & Emery
20090011502 - Pdx1 expressing endoderm: Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of... Agent: Knobbe Martens Olson & Bear LLP
20090011503 - Primate embryonic stem cells: A purified preparation of primate embryonic stem cells is disclosed. This preparation is characterized by the following cell surface markers: SSEA-1 (−); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+); and alkaline phosphatase (+). In a particularly advantageous embodiment, the cells of the preparation are human embryonic stem cells, have normal karyotypes,... Agent: Drinker Biddle & Reath LLP One Logan Square
20090011504 - Cultured cell construct which contains spheroids of cultured animal cells and the use thereof: Parenchymal cells are cultivated on cultivated endothelial cells or cultivated fibroblasts which have been separated by a surface of a specific hydrophilic polymer, and which have been patterned. A culture which contains thus formed patterned spheroids of cultivated parenchymal cells is thereby provided by this invention. This culture maintains a... Agent: Wenderoth, Lind & Ponack, L.L.P.
20090011505 - Method and device for the cryo-conservation of samples: A method and a device for the cryo-conservation of a hydrous sample, in particular biological sample, wherein the sample is introduced into a cavity of a container, remaining free space of the cavity if any is filled with a hydrous liquid, the cavity is closed in a liquid-tight manner and... Agent: Alexander R Schlee SchleeIPInternational P.C.
20090011506 - Apparatus and process for washing tissue and/or cell: An apparatus for washing cells and/or tissue includes an outer sleeve, an inner assembly, and a filter. The outer sleeve includes a closed end and an open end. The inner assembly is axially movable in the outer sleeve. The filter is affixed to the inner assembly, wherein a chamber is... Agent: Quintero Law Office, PC
20090011507 - scaffolds for use in tissue engineering to culture cells: A method of creating a scaffold, for use in tissue engineering to culture cells, comprises the steps of providing a base substrate; and embroidering a plurality of interconnected stitches (12, 14, 32) in the base substrate, each stitch (12, 14, 32) being embroidered using a biocompatible thread (16). A method... Agent: Dann, Dorfman, Herrell & Skillman
20090011508 - Method for the production of a strain having a deleted region in chromosome: The present invention is related to a method for the production of a strain having a deleted region in chromosome using a transformant having an increased frequency of homologous recombination due to suppression of a Ku gene, which is a mitosporic filamentous fungus belonging to Trichocomaceae, comprising transforming said transformant... Agent: Birch Stewart Kolasch & Birch
20090011509 - Integrase fusion proteins and their use with integrating gene therapy: In a method of targeting intergration of a transgene comprising retrovirus-like DNA into a eukaryotic genome, the genome is cleared by an endonuclease and the transgene is introduced at the site of cleavage, wherein the endonuclease is specific to a site in an abundant rDNA locus and is fused to... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20090011510 - Device and method for biolistic transformation of cells: The present invention provides a device and method for biolistic bombardment of cells. In a preferred embodiment, the device comprises a hollow tube or cylinder that attaches to a standard biolistic transformation apparatus, and focuses the nucleic acids at cells and tissue sections. In a typical configuration, the device has... Agent: Latimer, Mayberry & MatthewsIPLaw, LLP01/01/2009 > patent applications in patent subcategories. recently filed with US Patent Office
20090004640 - Method of paraffin-penetration treatment for tissue preparation and apparatus for the treatment: The present invention provides a paraffin-penetration treatment method for a tissue preparation, which is capable of enabling sufficient penetration of paraffin even into a tissue preparation, into which paraffin can hardly penetrate by a conventional paraffin-penetration treatment method. When the penetration of the paraffin into the tissue preparation is performed... Agent: Birch Stewart Kolasch & Birch
20090004642 - In vitro method for the determination of glycemic index of food products: The present invention provides an in vitro method for determining the glycemic index values for various food products. The present invention provides an accurate and inexpensive in vitro method for determining the glycemic index of a wide variety of both food ingredients and finished food products.... Agent: Fitch Even Tabin & Flannery
20090004641 - Site-specific labeling of affinity peptides in fusion proteins: The present invention provides methods and fluorescent compounds that facilitate detecting and labeling of a fusion protein by being capable of selectively binding to an affinity tag. The fluorescent compounds have the general formula A(B)n, wherein A is a fluorophore, B is a binding domain that is a charged chemical... Agent: Invitrogen Corporation C/o Intellevate
20090004644 - Methods and compositions for processes of rapid selection and production of nucleic acid aptamers: Embodiments herein relate to compositions and methods for making and using aptamers, for example, DNA aptamers (DCEs) and/or RNA aptamers. In some embodiments, methods relate to making and amplifying target DCEs. In certain embodiments, methods for making capture elements or aptamers concern using a reporter moiety and signal reducing moiety... Agent: Faegre & Benson LLP Patent Docketing
20090004643 - Methods for concurrent identification and quantification of an unknown bioagent: The present invention provides methods for the quantification of an unknown bioagent in a sample by amplification of nucleic acid of the bioagent, and concurrent amplification of a known quantity of a calibration polynucleotide from which are obtained a bioagent identifying amplicon and a calibration amplicon. Upon molecular mass analysis,... Agent: Casimir Jones, S.c.
20090004657 - 7b2 knockout transgenic animals as models of endocrine disease: In general, the invention features methods and uses for transposon-mediated gene targeting which greatly enhance the insertion and detection of desired genes in genomic exons by homologous recombination. The invention also features transgenic non-human mammals, and eukaryotic cells, wherein a gene encoding 7B2 protein is modified, as well as nucleic... Agent: Ropes & Gray LLP
20090004649 - Everninomicin biosynthetic genes: This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. The DNA sequence for the gene clusters responsible for encoding everninomicin... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)
20090004664 - Hcv ns3 replicon shuttle vectors: The present invention provides for novel HCV NS3 replicon shuttle vectors useful for cloning in HCV polynucleotide sequences from samples of HCV-infected patients and testing the resulting replicons for drug susceptibility.... Agent: Roche Palo Alto LLC Patent Law Dept. M/s A2-250
20090004658 - Integrin alpha 7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma: Methods are provided for determining the presence of a cancer in a biological sample, such as a tissue biopsy. The methods comprise determining if integrin alpha 7 expression is decreased in the biopsy which is indicative of the presence of a cancer or likelihood of relapse of a cancer. This... Agent: Jesse A. Hirshman, Esq.
20090004662 - Method and compositions for nucleic acid amplification: The present teachings provide methods, compositions, and kits for nucleic acid amplification. In some embodiments of the present teachings, amplification reactions are performed with at least one high stability primer. In some embodiments, the present teachings provide a method comprising a high stability primer for amplification of a nucleic acid... Agent: Mila Kasan, Patent Dept. Applied Biosystems
20090004660 - Method for detecting neuroblastoma and its malignancy and method for suppressing the same: An object of the present invention is to provide a method for detecting cancer and a cell growth inhibitor through identification of genes exhibiting characteristic behavior in the cases of cancer such as neuroblastoma. The present invention provides a method for detecting cancer, which comprises detecting canceration including malignancy of... Agent: Birch Stewart Kolasch & Birch
20090004667 - Method for generating aptamers with improved off-rates: The present disclosure describes improved SELEX methods for producing aptamers that are capable of binding to target molecules and improved photoSELEX methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having... Agent: Swanson & Bratschun, L.L.C.
20090004646 - Method for quantifying methylated dna: The inventive method makes it possible to quantify methylated DNA by combining the restricted digestion and real-time PCR. For this purpose, the inventive method consists in isolating the examined DNA from a biological sample, in reacting the isolated AND with a methylation specific restriction enzyme, in amplifying by means of... Agent: Kriegsman & Kriegsman
20090004654 - Method for the detection of bacterial species of the genera anaplasma/ehrlichia and bartonella: The present invention relates to a method for the detection and identification of bacterial species belonging to the genera Anaplasma/Ehrlichia and Bartonella, and also provides triggers and probes required for its application, as well as associated kits.... Agent: Darby & Darby P.C.
20090004666 - Method of detecting nucleotide sequence with an intramolecular probe: A nucleotide sequence-detecting method, including preparing a first intramolecular detecting sequence having a sequence complementary to a first sequence located at a 3′-side of the detecting site contained in the nucleotide sample and a second intramolecular detecting sequence having a sequence complementary to a second sequence located at a 5′-side... Agent: Scully Scott Murphy & Presser, PC
20090004661 - Method of growing mesenchymal stem cells from bone marrow: The present invention provides a method for culturing mesenchymal stem cells using cord blood serum, for therapeutic purposes in regenerative medicine; and in particular the present invention provides for the use of these cells in the treatment of PD, and the present invention has provided proliferation and neuronal differentiation of... Agent: Lackenbach Siegel, LLP
20090004647 - Method of judging grade of malignancy of carcinoma cell: Means for easily determining the grade of malignancy of cancer cells. The amount of ATBF1 in the whole cell structure of test cancer cells separated from a living organism is detected, and on the basis of detection results, the grade of malignancy of test cancer cells is judged. Alternatively, the... Agent: Kratz, Quintos & Hanson, LLP
20090004665 - Methods and compositions for isolating nucleic acid sequence variants: The invention is drawn to isolating sequence variants of a genetic locus of interest using a modified iterative primer extension method. The nucleic acids analyzed are generally single stranded and have a reference sequence which is used as a basis for performing iterative single nucleotide extension reactions from a hybridized... Agent: Bozicevic, Field & Francis LLP
20090004650 - Methods for detecting a cyclophilin b snp associated with herda: This invention provides compositions and methods for identification of carriers of Hereditary Equine Regional Dermal Asthenia (HERDA) in equine species. In particular, this invention identifies a single nucleotide polymorphorism (SNP) in cyclophlin B that can be used to identify carriers of HERDA and individuals affected by HERDA.... Agent: Townsend And Townsend And Crew, LLP
20090004652 - Methods for identifying and using snp panels: Described are methods for identifying single nucleotide polymorphism (SNPs) that are useful for analyzing genetic samples, and for using said SNPs to determine genetic identity of samples.... Agent: Fish & Richardson PC
20090004645 - Methods for identifying genes that mediate a response of a living cell to an agent: In one aspect, the present invention provides methods for determining whether a gene mediates the response of a living cell to an agent. In another aspect, the present invention provides methods to identify a mammalian subject responsive to a KSP inhibitor.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20090004669 - Methods of diagnosing pre-eclampsia or eclampsia: Disclosed herein are methods for diagnosing pre-eclampsia and eclampsia. Also disclosed herein are methods for treating pre-eclampsia and eclampsia using compounds that increase VEGF or PlGF levels or compounds that decrease sFlt-1 levels. Compounds that inhibit the binding of VEGF or PlGF to sFlt1- are also disclosed herein for the... Agent: Clark & Elbing LLP
20090004648 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of ovarian cancer: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623
20090004668 - Pre-mirna loop-modulated target regulation: By employing essential nucleotides from both the stem and loop of precursor-miRNA, greater specificity is achieved as to the mRNAs that are repressed. It is found that besides the seed sequence of the stem of the pre-miRNA, nucleotides in the loop affect the activity and specificity of the cursor- and... Agent: Robins & Pasternak
20090004659 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto
20090004663 - Real-time assays of neuro-humoral factors to assess cardiovascular stress: The present invention relates to rapid assays for neuro-humoral factors modulated in response to cardiovascular stress and integration of data obtained from such assays to provide profiles of response to cardiovascular stress that can guide therapy.... Agent: Baker Botts L.L.P.
20090004655 - Rna bioassay: The present invention relates to methods for evaluating the cell damaging potential of an agent by determining the ability of the agent to increase messenger RNA release in cells.... Agent: Pfizer Inc.
20090004651 - Screening methods for compounds that modulate the activity of g-protein coupled receptors: The present invention relates to a screening system for modulators of GPCRs. Further it relates to recombinant vector systems for the heterologous expression of heterodimeric g-protein coupled receptors (GPCRs) in eucaryotic host cells. Preferably the functional expression of engineered GPCRs for the perception of sweet and L-amino acid taste or... Agent: Propat, L.L.C.
20090004653 - Sulfonated [8,9]benzophenoxazine dyes and the use of their labelled conjugates: Fluorescent, sulfonated 3,7-diamino-[8,9]benzophenoxazine dyes are provided that are especially useful for labelling biopolymers and other substrates. The dye-labelled conjugates can be used in a variety of contexts, including cell surface assays employing intact, live cells and in nucleic acid detection methods. The new dyes are water soluble and can be... Agent: Brinks Hofer Gilson & Lione
20090004656 - Thermostable polymerases having altered fidelity and methods of identifying and using same: The present invention provides a method for identifying a thermostable polymerase having altered fidelity. The method consists of generating a random population of polymerase mutants by mutating at least one amino acid residue of a thermostable polymerase and screening the population for one or more active polymerase mutants by genetic... Agent: Nixon Peabody LLP - Patent Group
20090004672 - 17867, a novel human aminopeptidase: The present invention relates to a newly identified human aminopeptidase. The invention also relates to polynucleotides encoding the aminopeptidase. The invention further relates to methods using the aminopeptidase polypeptides and polynucleotides as a target for diagnosis and treatment in aminopeptidase-related disorders. The invention further relates to drug-screening methods using the... Agent: Banner & Witcoff, Ltd.
20090004671 - Marker protein for use in diagnosis of pancreatic cancer: Disclosed herein are a pancreatic carcinoma marker protein that is a blood protein having a molecular weight of 28,080±15, 17,272±9, 17,253±9, 8,766±5, or 14,779±8 (m/z) and a method for detecting pancreatic carcinoma using the marker protein as an indicator.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.
20090004673 - Method for determining condition of disseminated intravascular coagulation: A method for determining a condition of disseminated intravascular coagulation (DIC), by analyzing the amount and/or enzyme activity of a von Willebrand factor (vWF)-cleaving protease (ADAMTS13) (preferably also the amount of vWF) in a patient suffering from DIC, and a kit for determining a condition of DIC, comprising an antibody... Agent: Heslin Rothenberg Farley & Mesiti PC
20090004670 - Methods for fabricating surface enhanced fluorescent (sef) nanoparticles and their applications in bioassays: Embodiments of the invention relate to SEF nanoparticles with increased fluorescence, methods of making SEF nanoparticles, and their application in various bioassays for the detection of target bioanalytes. One embodiment includes the SEF nanoparticle itself, a second embodiment includes the fabrication of SEF nanoparticles, a third embodiment includes methods of... Agent: Client 21058 C/o Darby & Darby P.C.
20090004674 - Acpl-related assays: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.... Agent: Immunex Corporation Law Department
20090004676 - T1r3 receptor binding assays for identification of taste modulatory compounds: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically. T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department
20090004675 - Method of identifying compounds for bacterial growth modulation: The present invention relates to a method of identifying a candidate compound for modulating bacterial growth. This the method involves providing a β clamp peptide from a bacterial replicase, providing a second peptide that binds to at least one amino acid of SEQ ID NO:9 that is not designated X,... Agent: Nixon Peabody LLP - Patent Group
20090004677 - Quantitative determination of bcl10: Methods of and kits for quantitatively determining the concentrations of Bcl10 in a biological sample were developed that provide an accurate means of identifying therapeutic molecules with a plurality of therapeutic effects. A solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) for human Bcl10 that provides reproducible, precise measurements was developed and... Agent: Akerman Senterfitt
20090004680 - Determining and reducing immunoresistance to botulinum toxin therapy using botulinum toxin a peptides: The present invention provides BoNT/A peptide compositions, tolerogizing compositions, BoNT/A immune response inducing compositions and antibody compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of preventing or reducing immunoresistance to botulinum toxin therapy in an individual, methods of vaccinating an individual against... Agent: Allergan, Inc.
20090004679 - Method for determining plasminogen activator inhibitor: A method is provided for determining active plasminogen activator inhibitor—Type 1 (PAI-1) in a biological fluid, the method comprising the steps of (i) providing a sample of a biological fluid; and (ii) measuring the amount of PAI-1/multimeric vitronectin complex in the sample to determine active PAI-1 in the sample. A... Agent: Myers Bigel Sibley & Sajovec
20090004678 - Method for screening fertility and new compounds or molecules, using crt or erp57 translocation: A screening method for testing the immunogenicity of new molecules and compounds and for testing fertility and sterility conditions. The method includes inducing a translocation of a calreticulin protein and/or an ERP57 protein, to a cellular membrane in order to determine the immunogenicity of the new molecules and compounds, or... Agent: Samuel A. Kassatly
20090004681 - Platelet aggregation measuring method and platelet aggregation measuring apparatus: A platelet aggregation measuring method comprising: preparing a measurement sample which contains a sample and a reagent which includes a platelet activator; mixing the measurement sample at a first speed; mixing the measurement sample at a second speed which is greater than the first speed after mixing the sample at... Agent: Sughrue Mion, PLLC
20090004682 - Method for measuring glucose concentration in blood using infrared spectroscopy and instrument employing it: The objective of the present invention is to provide a method and instrument for measuring glucose concentration in blood using infrared spectroscopy. Glucose concentration in blood is measured based on an integrated value obtained by measuring an absorption spectrum that includes the wavelength range of 1020-1040 cm−1, and by integrating... Agent: Baker Botts L.L.P.
20090004683 - Indicator agent for noninflammatory stress response and use thereof: A system enabling the molecular biological visualization and quantitative detection of events in a stress-exposed living organism and a means enabling the management of stress are provided. An indicator agent for non-inflammatory stress responses mediated by superoxide, which comprises IL-18, a visualizing agent for non-inflammatory stress responses for detecting the... Agent: Wenderoth, Lind & Ponack, L.L.P.
20090004684 - Compositions and methods for detection and quantification of protein oxidation: Compositions and methods for detecting carbonyl functional groups on polypeptides are disclosed.... Agent: Dann, Dorfman, Herrell & Skillman
20090004685 - Interface device and method for using the same: The present disclosure is related to an interface device for providing access to a network to be monitored. The interface device includes a plurality of elements, the elements being sensors and/or actuators. A selection means is provided for selecting a subset of elements among the plurality of elements, each element... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20090004686 - Measurement and uses of oxidative stress: The present invention provides a method of determining the overall oxidative status of a body fluid or a tissue of a patient by measuring the oxidation-reduction potential (ORP) of the body fluid or tissue. The method has been found to be useful in the diagnosis, evaluation and monitoring of patients... Agent: Sheridan Ross PC
20090004687 - Predictive markers for ovarian cancer: Methods are provided for predicting the presence, subtype and stage of ovarian cancer, as well as for assessing the therapeutic efficacy of a cancer treatment and determining whether a subject potentially is developing cancer. Associated test kits, computer and analytical systems as well as software and diagnostic models are also... Agent: Cooley Godward Kronish LLP Attn: Patent Group
20090004688 - Sampling system and method: A sampling system and method may use a kit that has a package enclosing a swab and a receptacle. The swab may have a shaft and a tip. The tip may be substantially made of calcium alginate. The receptacle may contain a diluent, such as sodium citrate, and glass beads.... Agent: Beem Patent Law Firm
20090004689 - Lineage restricted glial precursors from the central nervous system: A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM− glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5− fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from... Agent: Kathleen A. Tyrrell Licata & Tyrell P.C.
20090004690 - Composition and methods for making 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine: Presented is a method to detect precancerous states in mammalian cell and tissue samples comprising incubating a sample with solubilized 5, 10, 15, 20-tetrakis (carboxyphenyl)porphine (TCPP), measuring TCPP fluorescence in the sample, and categorizing the sample as non-cancerous, precancerous or cancerous based on TCPP fluorescence, as correlated with the respective... Agent: Peacock Myers, P.C.
20090004691 - Enhanced fluidic method and apparatus for automated rapid immunohistochemistry: A sample processing system that may be configured to achieve rapid sample processing such as rapid histochemical processing may involve a wave element that can use angular microscopic slide movements to cause repeated elimination and reapplication of a fluidic substance perhaps through the action of capillary motion in order to... Agent: Santangelo Law Offices, P.C.
20090004692 - Methods to enhance the activity of lignocellulose-degrading enzymes: Methods for hydrolyzing lignocellulose are provided, comprising contacting the lignocellulose with at least one chemical treatment. Methods for pretreating a lignocellulosic material comprising contacting the material with at least one chemical are also provided. Methods for liberating a substance such as an enzyme, a pharmaceutical, or a nutraceutical from plant... Agent: Alston & Bird LLP
20090004695 - Process for constructing strain having compactin hydroxylation ability: The present invention is directed to methods and compositions for microbial based production of pravastatin. The compositions of the invention include novel strains of microorganisms that are capable of efficiently hydroxylating compactin (ML-236 B) resulting in production of pravastatin. In particular, the microorganisms of the invention are genetically engineered to... Agent: Kenyon & Kenyon LLP
20090004693 - Production of polypeptides by improved secretion: The present invention relates to polypeptides that have an activity corresponding to at least one activity of the SEC61 polypeptide, polynucleotides encoding these polypeptides and the use thereof in the preparation of host cells suitable for production of a polypeptide of interest. Such host cells may have an increased capacity... Agent: Nixon & Vanderhye, PC
20090004694 - Sequence of thermotolerant l-rhamnose isomerase gene and use of the same: [PROBLEMS] To provide the sequence of a thermotolerant L-rhamnose isomerase gene. [MEANS FOR SOLVING PROBLEMS] A DNA comprising the base sequence represented by SEQ ID NO:1. A protein comprising the amino acid sequence represented by SEQ ID NO:2. A protein originating in Bacillus pallidus strain 14a (FERM AP-20172) and having... Agent: Westerman, Hattori, Daniels & Adrian, LLP
20090004696 - Stabilized bioactive peptides and methods of identification, synthesis, and use: An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group... Agent: Mueting, Raasch & Gebhardt, P.A.
20090004697 - Generation of chemical building blocks from plant biomass by selective depolymerization: The invention concerns a method for the enzymatic treatment of raw polymeric feedstock comprising the following steps: (a) preferably separation of soluble components from the raw polymeric feedstock, (b) treating the raw polymeric feedstock with an enzyme system in order to liberate defined soluble monomeric or oligomeric building blocks from... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20090004698 - Methods to enhance the activity of lignocellulose-degrading enzymes: Methods for hydrolyzing lignocellulose are provided, comprising contacting the lignocellulose with at least one chemical treatment. Methods for pretreating a lignocellulosic material comprising contacting the material with at least one chemical are also provided. Methods for liberating a substance such as an enzyme, a pharmaceutical, or a nutraceutical from plant... Agent: Alston & Bird LLP
20090004699 - Process for producing beta-chitin: The method of the present invention for producing β-chitin comprises a step of cultivating an alga capable of producing β-chitin using a medium that contains nitrogen (N), phosphorus (P), silicon (Si), and selenium (Se), wherein the weight ratio of phosphorus to nitrogen (P/N) is 0.1 or above, the weight ratio... Agent: Mcleland Patent Law Office, P.l.l.c.
20090004700 - Chemical induction in quiescence in bacteria: Quiescence is induced in cells using indole compounds. Expression continues from extra-chromosomal vectors within the cells during quiescence, while chromosomal expression is suppressed. The cells may be used as factories for the production of large amounts of polypeptides of interest, particularly polypeptides which normally have an adverse effect on cell... Agent: Klarquist Sparkman, LLP
20090004702 - Codon specific mutagenesis: Materials and Methods are provided for replacing one or more amino acids in a polypeptide with an amino acid of choice to form mutant proteins. Both naturally and non-naturally occurring amino acids can be inserted. A population of mutant proteins can be created in which an amino acid residue has... Agent: Arent Fox LLP
20090004701 - Multiplex oligonucleotide addition and target amplification: Methods for appending oligonucleotides directly to nucleic acid templates, particularly to defined sites internal to single-stranded templates, are described. Appending first and second common priming sites to each of a plurality of templates of distinct sequence allows the subsequent stoichiometric amplification of a plurality of templates of distinct sequence.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.
20090004703 - Method for the production of suitable dna constructs for specific inhibition of gene expression by rna interference: The invention relates to a method for the production of vectors which, following transfection thereof in eukaryotic cells, are suitable for targeted inhibition of the formation of defined proteins therein by RNA interference. The method for the production of such vectors does not include any PCR steps. It is a... Agent: Joyce Von Natzmer Pequignot + Myers LLC
20090004704 - Xylitol dehydrogenase-inactivated and arabinose reductase-inhibited mutant of candida tropicalis, method of producing high-yield of xylitol using the same, and xylitol produced thereby: Disclosed herein are Xylitol dehydrogenase-inactivated and arabinose reductase-inhibited mutant of Candida tropicalis, a method of producing a high yield of xylitol using the same, and xylitol produced by the method. More specifically, disclosed are a method for producing a high yield of xylitol, in which a high concentration of xylose... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20090004705 - Psod expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000
20090004706 - Methods to enhance the activity of lignocellulose-degrading enzymes: Methods for hydrolyzing lignocellulose are provided, comprising contacting the lignocellulose with at least one chemical treatment. Methods for pretreating a lignocellulosic material comprising contacting the material with at least one chemical are also provided. Methods for liberating a substance such as an enzyme, a pharmaceutical, or a nutraceutical from plant... Agent: Alston & Bird LLP
20090004707 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP
20090004708 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP
20090004709 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP
20090004710 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP
20090004711 - Process for producing glycolic acid from formaldehyde and hydrogen cyanide: A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile having low concentrations of impurities. The glycolonitrile is subsequently converted to an aqueous solution of ammonium glycolate using an enzyme catalyst having nitrilase activity derived... Agent: Woodcock Washburn LLP
20090004712 - Drying apparatus and methods for ethanol production: The apparatus and methods disclosed herein relate to the production of dried co-products from stillage produced by an ethanol production facility. In various aspects, the apparatus and methods disclosed herein relate to an ethanol production facility that produces ethanol and stillage from grain, and a pulse combustion dryer in communication... Agent: Cyr & Associates, P.A.
20090004713 - Membrane-augmented distillation with pressure change to separate solvents from water: Processes for removing water from organic solvents, such as ethanol. The processes include distillation in two columns operated at sequentially higher pressure, followed by treatment of the overhead vapor by one or two membrane separation steps.... Agent: Membrane Technology And Research Inc.
20090004714 - Non-pressurised pre-treatment, enzymatic hydrolysis and frementation of waste fractions: The present invention relates to a process for production of fermentation products, including bioethanol by non-pressurised pre-treatment, enzymatic hydrolysis and fermentation of waste fractions containing mono- and/or polysaccharides, having a relatively high dry matter content. The process in its entirety, i.e. from non-pressurised pre-treatment over enzymatic hydrolysis and fermentation to... Agent: Budde, Schou & Ostenfeld, A/s
20090004715 - Glycerol feedstock utilization for oil-based fuel manufacturing: The invention provides methods of manufacturing biodiesel and other oil-based compounds using glycerol and combinations of glycerol and other feedstocks as an energy source in fermentation of oil-bearing microorganisms. Methods disclosed herein include processes for manufacturing high nutrition edible oils from non-food feedstock materials such as waste products from industrial... Agent: Townsend And Townsend And Crew, LLP
20090004716 - Compositions comprising high concentration of biologically active molecules and processes for preparing the same: Large scale processes for producing high purity samples of biologically active molecules of interest from bacterial cells are disclosed. The methods comprise the steps of producing a lysate solution by contacting a cell suspension of said plurality of cells with lysis solution; neutralizing said lysate solution with a neutralizing solution... Agent: Pepper Hamilton LLP
20090004717 - Device and method to facilitate directed delivery and electroporation using a charged stream: A method for facilitating a delivery of a molecule into an interior space of a cell includes the steps of introducing a molecule into a biological structure comprising a cell and applying a substantially continuous low-level electric field, in the form of non-thermal plasma (ionized gas) generated by a direct... Agent: Smith Hopen, Pa
20090004718 - Antioxidant fermenting microorganism agent reducing volatile organic compounds from polyurethane foam, and urethane foam comprising the same: Disclosed is an antioxidant fermenting microorganism agent and a polyurethane foam including the same. The antioxidant fermenting microorganism agent is used to generate a substance that is capable of reducing an amount of volatile organic compounds generated from the polyurethane foam and has an antimicrobial ability. The polyurethane foam containing... Agent: Hamre, Schumann, Mueller & Larson, P.C.
20090004719 - Protein-protein interactions in human immunodeficiency virus: The present invention relates to protein-protein interactions involved in AIDS. More specifically, the present invention relates to complexes of polypeptides or polynucleotides encoding the polypeptides, fragments of the polypeptides, antibodies to the complexes, Selected Interacting Domains (SID®) which are identified due to the protein-protein interactions, methods for screening drugs for... Agent: Lerner, David, Littenberg, Krumholz & Mentlik
20090004720 - Smart biocatalysts for organic synthesis: The present disclosure relates to compositions, systems, and methods that include a reusable biocatalyst. A reusable biocatalytic composition may include a stimulus-responsive support operable to be soluble under at least one first condition and insoluble under at least one second condition; and a biocatalyst bound to the stimulus-responsive support complex.... Agent: Baker Botts L.L.P.
20090004721 - Dengue virus mutant strain mbu 01-2002: The invention includes a genetic construct and a mutant dengue virus, designated as strain MBU 01-2002, which is a mutant dengue virus generated by genetic modification of the 13-amino acid sequence just proximal to the pr-M junction within the prM coding region of the genome. The modification involves increasing the... Agent: Ms. Nuttina Netsuwan
20090004722 - Recombinant parainfluenza virus expression systems and vaccines: The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. The chimeric viruses and expression products... Agent: Medimmune, LLC Jonathan Klein-evans
20090004723 - Methods and compositions concerning poxviruses and cancer: The present invention concerns methods and compositions for the treatment of cancer and cancer cells using altered poxviruses, including a vaccinia virus that has been altered to generate a more effective therapeutic agent. Such poxviruses are engineered to be attenuated or weakened in their ability to affect normal cells. In... Agent: Fulbright & Jaworski L.L.P.
20090004724 - Method for enhancing production of isoprenoid compounds: The present invention provides methods of producing an isoprenoid or an isoprenoid precursor in a genetically modified host cell. The methods generally involve modulating the level of hydroxymethylglutaryl-CoA (HMG-CoA) in the cell, such that the level of HMG-CoA is not toxic to the cell and/or does not substantially inhibit cell... Agent: Bozicevic, Field & Francis LLP
20090004725 - Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby: Namely, the present invention includes a protein participating in the addition of mannose phosphate to a sugar chain of a glycoprotein; a gene coding this protein; a mutant of this gene; a vector carrying the mutant gene; a yeast strain belonging to the genus Pichia having been transformed by this... Agent: Kilyk & Bowersox, P.l.l.c.
20090004726 - Inhibitor tolerant saccharomyces cerevisiae strain: Furfural and 5-hydroxymethylfurfural (HMF) are representative inhibitors to ethanologenic yeast generated from biomass pretreatment using dilute acid hydrolysis. Few yeast strains tolerant to inhibitors are available. A novel tolerant strain of Saccharomyces cerevisiae, NRRL Y-50049, having enhanced biotransformation ability to convert furfural to furan methanol (FM), HMF to furan di-methanol... Agent: Usda-ars-office Of Technology Transfer National Ctr For Agricultural Utilization Research
20090004727 - Method for the separation of microorganisms adhered to a solid sample by means of a phosphate-based damper and sonication of the sample: The present invention provides a method for the separation of microorganisms of a microbiological community present in a solid sample. And once the microorganisms are isolated, they are used in microbiological techniques, or their nucleic acids, both DNA and RNA, are extracted from them for carrying out molecular biology techniques.... Agent: Merchant & Gould PC
20090004728 - Method of biotreatment for solid materials in a nonstirred surface bioreactor: A method of biotreating a solid material to remove an undesired compound using a nonstirred surface bioreactor is provided. According to the method, the surface of a plurality of coarse substrates is coated with a solid material to be biotreated to form a plurality of coated coarse substrates. The coarse... Agent: Jones Day
20090004729 - Reaction device: A reaction device including: a plurality of reaction areas; and a plurality of heating parts configured to be each provided for a respective one of the reaction areas, wherein each of the heating parts includes: a heat source; a scan line for selecting the heating part; a data line that... Agent: Bell, Boyd & Lloyd, LLP
20090004730 - Cell obsevation aiding instrument and method of cell observation therewith: A cell observation support instrument having opposed first and second surface members 115 and 117 and stoppers that are positioned between the first and second surface members 115 and 117 in order to prevent movement of cells. The first and second surface members 115 and 117 form a cell-containing space... Agent: Antonelli, Terry, Stout & Kraus, LLP
20090004731 - Cell culture apparatus and a fabricating method of the same: A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of:... Agent: Bacon & Thomas, PLLC
20090004732 - Chemical temperature control: Exothermic and/or endothermic chemical reactions in combination with phase change materials can produce output temperature(s) within strict tolerances without requiring expensive and complicated external equipment to generate and maintain an output temperature. Similarly, an exothermic phase change material, which generates heat as a consequence of crystallizing a supercooled liquid, can... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.
20090004734 - Mutated anti-cd22 antibodies with increased affinity to cd22-expressing leukemia cells: Recombinant immunotoxins are fusion proteins composed of the Fv domains of antibodies fused to bacterial or plant toxins. RFB4 (Fv)-PE38 is an immunotoxin that targets CD22 expressed on B cells and B cell malignancies. The present invention provides antibodies and antibody fragments that have improved ability to bind the CD22... Agent: Townsend And Townsend And Crew, LLP
20090004733 - Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides, and uses thereof: The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations... Agent: Novartis Vaccines And Diagnostics Inc.
20090004735 - Promoter and its use: A promoter comprising nucleotides from positions 2489-3038 of FIG. 3.... Agent: Millen, White, Zelano & Branigan, P.C.
20090004736 - Generation of neural stem cells undifferentiated human embryonic stem cells: The present invention relates to the generation of neural cells from undifferentiated human embryonic stem cells. In particular it relates to directing the differentiation of human ES cells into neural progenitors and neural cells and the production of functioning neural cells and/or neural cells of a specific type. The invention... Agent: Scully, Scott, Murphy & Presser, P.C.
20090004737 - Microfluidic devices and methods for fabricating the same: A microfluidic device includes, in one embodiment, a first silk film coupled to a second silk film with at least one microchannel therebetween.... Agent: Goodwin Procter LLP Patent Administrator
20090004738 - Method and apparatus for maintenance and expansion of hemopoietic stem cells and/or progenitor cells: A method of preparing a stromal cell conditioned medium useful in expanding undifferentiated hemopoietic stem cells to increase the number of the hemopoietic stem cells is provided. The method comprising: (a) establishing a stromal cell culture in a stationary phase plug-flow bioreactor under continuous flow on a substrate in the... Agent: Martin D. Moynihan D/b/a Prtsi, Inc.
20090004739 - Efficient method of preparing dna inverted repeat: In this invention, a cassette construct comprising an arbitrary adaptor sequence and an inverted adaptor sequence separated by an arbitrary spacer sequence or a plasmid vector comprising such cassette construct incorporated therein is prepared, a target sequence is ligated to either or both ends of the cassette construct, or a... Agent: Greenblum & Bernstein, P.L.C
20090004741 - Biodegradable polyphosphoramidates for controlled release of bioactive substances: The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery... Agent: Greenberg Traurig LLP (la)
20090004740 - Primate totipotent and pluripotent stem cells produced by somatic cell nuclear transfer: Purified totipotent stem cells and pluripotent stems cells derived by somatic cell nuclear transfer are disclosed herein, as well as cell lines, multipotent cells and differentiated cells produced from these stem cells. The stem cells are produced from an enucleated host cell from a first donor and nuclear genetic material... Agent: Klarquist Sparkman, LLP
20090004742 - Selection of antigen-specific t cells: The requirement of T cell activation for efficient expression of genes after messenger ribonucleic acid (mRNA) transfection is leveraged to identify and enrich antigen-specific T cells responding to antigen-pulsed dendritic cells (DCs). RNA transfection of marker genes is used for the selection and enrichment of antigen-specific T cells for use... Agent: Banner & Witcoff, Ltd.
20090004743 - Helper virus-free aav production: A method for the production of adeno-associated virus stocks and recombinant adeno-associated virus stocks that are substantially free of contaminating helper virus is described. The method utilizes transfection with helper virus vectors to replace the infection with helper virus used in the conventional method.... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20090004744 - Minicells as vaccines: The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.... Agent: Knobbe Martens Olson & Bear LLP
20090004745 - P19 expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000Previous industry: Education and demonstration
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