Chemistry: molecular biology and microbiology inventions 12/08

20080318202 - Chimeric pancreas: Novel methods, tissues and compositions for increasing the pancreatic mass of a mammalian recipient including harvesting immature pancreatic tissue from a mammalian donor and transplanting said tissue into the peritoneal cavity of a mammalian recipient under conditions that allow the pancreatic tissue to become vascularized and mature, thereby developing a... Agent: Washington University-snr C/o Sonnenschein Nath & Rosenthal L.l.p

20080318203 - Novel microfluidic system and method for capturing cells: The invention concerns a microfluidic device and its uses for capturing subset of cells in a biological fluid. Said device comprises a chamber (1) for circulating fluids whereof an inner wall (5) is provided with a covalent immobilization surface in the form of an organized self-assembled silane layer, whereto is... Agent: Alston & Bird LLP

20080318208 - Dengue reporter virus and methods of making and using the same: The present invention relates to the production and uses of Dengue virus replicons and Dengue reporter virus particles. The present invention relates to methods of identifying inhibitors of Dengue virus infection, inhibitors of Dengue virus replication, and inhibitors of Dengue virus assembly.... Agent: Pepper Hamilton, LLP

20080318206 - Detection of herpes simplex virus types 1 and 2 by nucleic acid amplification: The present invention relates to a method of detecting the presence or absence of herpes simplex virus (HSV) in a sample based on amplifying a portion of the Glycoprotein G (US4) gene of HSV and detecting the presence of the amplified nucleic acid using primers and detector primers as described... Agent: Morgan & Finnegan, L.L.P.

20080318204 - Highly-sensitive genomic assays employing chimeric bacteriophage standards: Methods are provided for sensitively quantitating at least one pre-selected DNA sequence in a biological sample utilizing hybridization methodology, the method employing as an internal standard an infectious bacteriophage particle comprising a detectable target DNA sequence other than that present in the pre-selected DNA sequence or in DNA quantitated from... Agent: Klauber & Jackson

20080318205 - Hiv type and subtype detection: The present invention relates to the detection of HIV by amplification and PCR-based methods.... Agent: Birch Stewart Kolasch & Birch

20080318207 - Sequence covariance networks, methods and uses therefor: Methods of identifying targets for designing a therapeutic agent are disclosed. These methods comprise: determining an amino acid sequence of one or more polypeptides of each isolate of a plurality of isolates of a biological system; identifying covariance pairs of amino acid residues; establishing a network comprising the covariance pairs;... Agent: Sonnenschein Nath & Rosenthal LLP

20080318231 - 14-3-3 zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer type: Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more... Agent: Fulbright & Jaworski L.L.P.

20080318215 - Apparatus, methods and products for detecting genetic mutation: Methods for detecting genetic mutation allowing detection of very low frequency mutation. Methods comprise treating RNA:DNA heteroduplexes of interest with ribonuclease treatment coupled with DNA polymerase treatment. RNA:DNA heteroduplexes of interest are preferentially targeted for digestion by ribonuclease and subsequent sequence extension by DNA polymerase. Methods may be carried out... Agent: J. M. (mark) Gilbreth Gilbreth Roebuck

20080318210 - Bioinformatically detectable group of novel regulatory viral and viral associated oligonucleotides and uses thereof: The present invention relates to a first group of novel viral and human associated oligonucleotides, here identified as Genomic Address Messenger or GAM oligonucleotide, and a second group of novel operon-like viral and human polynucleotides, here identified as Genomic Record or GR polynucleotide. GAM oligonucleotides selectively inhibit translation of known... Agent: Rosetta-genomics C/o Psws

20080318228 - Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents: Biomarkers that are useful for identifying a mammal that will respond therapeutically or is responding therapeutically to a method of treating cancer that comprises administering a microtubule-stabilizing agent. In one aspect, the cancer is breast cancer, and the microtubule-stabilizing agent is an epothilone or analog or derivative thereof, or ixabepilone.... Agent: Louis J. Wille Bristol-myers Squibb Company

20080318222 - Cell based methods and systems for the identification of rna regulatory sequences and compounds that modulate their functions: The present invention is directed to an in vivo method for screening for and/or identifying RNA regulatory sequences involved in translational control. The method includes: culturing cells including: (i) a translational system; (ii) a reporter mRNA; and (iii) an RNA test sequence under suitable conditions for translation of the reporter... Agent: Hoffmann & Baron, LLP

20080318236 - Cell free screening assay and methods of use: Methods are disclosed for identifying agents for the treatment of cancer and/or Fanconi anemia using Xenopus egg cell free extracts from which the endogenous DNA has been removed. The assays and method described herein are easily adaptable to high throughput techniques for example to screen large numbers of agents as... Agent: Klarquist Sparkman, LLP

20080318235 - Chromosomal analysis by molecular karyotyping: The invention provides a method of karyotyping (for example for the detection of trisomy) a target cell to detect chromosomal imbalance therein, the method comprising: (a) interrogating closely adjacent biallelic SNPs across the chromosome of the target cell (b) comparing the result at (a) with the SNP haplotype of paternal... Agent: Michael Best & Friedrich LLP

20080318209 - Cjd prion testing: The present invention provides an assay method for detecting infectious prion protein in a sample from a mammalian subject, said method comprising: obtaining a prion protein containing sample from said subject; contacting said sample with an agent which serves to digest non-infectious prion protein and to partially digest infected prion... Agent: Bacon & Thomas, PLLC

20080318225 - Compositions and methods for detecting cancer: The present invention provides methods and compositions involving detecting the presence of and/or assessing the risk of cancer in a subject. These methods include methods of detecting and diagnosing cancer in an individual; methods of identifying individuals at risk of developing a cancer; and methods of staging a cancer. The... Agent: Bozicevic, Field & Francis LLP

20080318234 - Compositions and methods for diagnosing and treating cancer: The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles associated with solid tumor stem cells, as well as novel stem cell cancer gene signatures useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080318218 - Compositions and methods for inferring an adverse effect in response to a drug treatment: Methods are provided for inferring whether a subject to be treated with a drug such as a statin or an ACE inhibitor is likely to suffer an adverse effect due to the treatment. Also provided are compositions for practicing the methods.... Agent: Dla Piper LLP (us)

20080318239 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Goodwin Procter LLP Attn: Patent Administrator

20080318243 - Dna measuring system and method: The present invention provides a DNA sequencer using a FET sensor, capable of long-base decoding. Target DNAs are immobilized on the surfaces of spherical fine particles, the fine particles are disposed in the vicinity of metal electrodes each of which is connected electrically to a corresponding one of conductive wirings... Agent: Stanley P. Fisher Reed Smith LLP

20080318230 - Gene expression markers for response to egfr inhibitor drugs: The present invention concerns prognostic markers associated with cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed samples of cancer tissue, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR... Agent: Bozicevic, Field & Francis LLP

20080318214 - Genome analysis method: This invention makes it possible to perform analysis for estimating the characteristics of a population using sample data. By obtaining sample data, embedding genetic (statistical) knowledge in a first and second state variable that have duality, and having the first and second state variables converge to the original value, the... Agent: Akerman Senterfitt

20080318217 - Identification of gene associated with reading disability and uses therefor: The present invention relates to identification of a human gene, DCDC2 (MIM: 605755), associated with susceptibility for developing reading disability (RD), which is useful in identifying or aiding in identifying individuals at risk for developing RD, as well as for diagnosing or aiding in the diagnosis of RD.... Agent: Wolf Greenfield & Sacks, P.C.

20080318227 - Intermediates and enzymes of the non-mevalonate isoprenoid pathway: The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2-butenyl... Agent: Myers Bigel Sibley & Sajovec

20080318223 - Large deletions in human brca1 gene and use thereof: Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to cancer.... Agent: Myriad Genetics Inc. Intellecutal Property Department

20080318224 - Large deletions in human brca1 gene and use thereof: Large deletions have been identified in the BRCA1 gene in patients. The large deletions predispose the patients to breast cancer and ovarian cancer. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to cancer.... Agent: Myriad Genetics Inc. Intellecutal Property Department

20080318244 - Large-scale parallel nucleic acid analysis method: It is intended to provide a technique for amplifying, individually and in parallel, nucleic acids contained in a mixture of plural kinds of nucleic acid samples. The present invention provides a nucleic acid analysis method comprising amplification means, whereby amplification reaction is performed in a reaction solution comprising a homogeneous... Agent: Reed Smith LLP

20080318213 - Mass spectrometer: A mass spectrometer and a method of spectrometry are disclosed wherein liquid chromatography mass spectral data are probabilistically clustered on the basis of mass to charge ratio and retention time.... Agent: Waters Investments Limited C/o Waters Corporation

20080318229 - Method for diagnosing neuro-degenerative disease: A method for the diagnosis of Alzheimer's Disease (AD) or Parkinson's Disease (PD), comprises measuring the level of expression of one or more AD markers (Table 1) or PD markers (Table 2) in a sample of platelets isolated from a person suspected of having AD or PD, and determining whether... Agent: Oliff & Berridge, PLC

20080318220 - Method for the diagnosis and/or prognosis of alzheimer's disease: The present invention relates to a method for the diagnosis and/or prognosis of Alzheimer's disease by means of determining the ZMIZ1 gene expression level in a biological sample and comparing said level with a reference value, in which the alteration of said level is indicative of Alzheimer's disease.... Agent: Sughrue Mion, PLLC

20080318221 - Method for the diagnosis and/or prognosis of alzheimer's disease: The present invention relates to a method for the diagnosis and/or prognosis of Alzheimer's disease by means of determining the DARC gene expression level in a biological sample and comparing said level with a reference value, in which the disturbance of said level is indicative of Alzheimer's disease.... Agent: Sughrue Mion, PLLC

20080318238 - Method of detecting gene mutation: DNA amplification and hybridization are successively carried out in a reaction system containing primers for the DNA amplification and hybridization probes, followed by detecting the hybrid in the reaction solution by affinity chromatography, wherein at least one of the primers to be used in the DNA amplification is labeled with... Agent: Sonnenschein Nath & Rosenthal LLP

20080318219 - Methods and compositions for predicting drug responses: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.... Agent: Nixon Peabody LLP - Patent Group

20080318242 - Methods and devices for early detection of cancer cells and types through micromechanical interactions: Methods and devices for detecting a cancer cell and cancer cell types in a sample of a subject are provided.... Agent: Ogilvy Renault LLP

20080318241 - Methods and systems for detecting antiangiogenesis: The present invention provides methods and systems for the detection of tumor vessel response to antiangiogenic therapies. The present invention also provides compositions and methods for therapeutic and research applications. In particular, the present invention provides systems and methods that employ CD26, HIF-1, and HIF-1 pathway components as biomarkers for... Agent: Casimir Jones, S.c.

20080318216 - Methods for determining presence of cancer by analyzing the expression of cdk9 and/or cyclin t1 in lymphoid tissue: A method for determining presence of lymphoma in a patient is disclosed. A sample of bone marrow, thymus, spleen, lymph nodes, lymph and/or lymphocytes taken from the patient t is assayed to determine expression of CDK9 and CYCLIN T1. The presence of CDK9 and/or CYCLIN T1 is indicative of a... Agent: Reed Smith LLP

20080318240 - Methods for utilizing esr copy number changes in breast cancer treatments and prognoses: The present invention relates to methods for estimation of efficacy of therapeutic treatment of cancer patients, in particular breast cancer patients. The estimation is based on determining of the status of aberration of the estrogen receptor alpha gene (ESR1) in situ, and, optionally, the status of aberration of a gene... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080318237 - Methods of diagnosing endometriosis: The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for endometriosis by detecting the expression levels of biomarkers, which are differentially expressed (up- or down-regulated) in endometrial cells from a patient with... Agent: Townsend And Townsend And Crew, LLP

20080318232 - Nucleic acid biosensor with photoelectrochemical amplification: The present invention relates to electrode systems, methods, apparatus and chips for ultrasensitive detection and quantification of nucleic acids using photoelectrochemical amplification. Upon hybridization of a target nucleic acid to a nucleic acid capture probe, a photoreporter comprising a threading bis-intercalator selectively binds to double-stranded nucleic acid. The stability and... Agent: Townsend And Townsend And Crew, LLP

20080318212 - Orphan receptor tyrosine kinase as a target in breast cancer: Methods and materials relating to the orphan receptor tyrosine kinase (ROR1) are described. ROR1 exhibits restricted tissue expression in normal adult tissue and is overexpressed in certain breast cancer subtypes. ROR1 provides a diagnostic and/or therapeutic target for breast cancers.... Agent: Gates & Cooper LLP Howard Hughes Center

20080318226 - Signal amplification method: Provided are a signal amplification method of improving signal sensitivity, qualifying properties and handling property in detection of a target gene by using a PALSAR method, a method of detecting a target gene by using the method, and an oligonucleotide probe to be used in the method. A signal amplification... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080318233 - Source tagging and normalization of dna for parallel dna sequencing, and direct measurement of mutation rates using the same: This invention allows efficient tagging and normalization of DNA molecules prior to pooling and characterization using parallel DNA sequencing (e.g., commercially available 454 sequencers). The invention provides novel ways to process independent DNA samples (sources) so that similar numbers of molecules from each source are represented in the pool (i.e.,... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080318247 - Biomarker for cardiac transplant rejection: The invention provides a method of diagnosing a disease or disorder featuring an abnormal level of a ring-containing molecule in a tissue. In one embodiment, a method of diagnosing organ transplant rejection is provided.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20080318248 - Compositions and methods of screening apoproteins: The present invention is directed to compositions and methods of screening apoproteins for the elucidation of modulators of metalation of apoproteins.... Agent: Alston & Bird LLP

20080318246 - Deeply quenched enzyme sensors: Sensors for detecting enzyme activity are provided that include a substrate module comprising a substrate for the enzyme of interest and a fluorescent label, a quencher, and a detection module. The detection module binds to the substrate module either before or after the enzyme acts on the substrate and sequesters... Agent: Quine Intellectual Property Law Group, P.C.

20080318245 - Nanotube structures having a surfactant bilayer inner wall coating: Nanotubes and nanotube array structures comprise (a) a nanotube having an inner wall portion; and (b) a bilayer coating formed on the inner wall portions, with the bilayer coating comprised of surfactants. A secondary compound such as a protein, peptide or nucleic acid may be associated with the bilayer coating.... Agent: Myers Bigel Sibley & Sajovec

20080318250 - Compositions and methods for identifying sperm for forensic applications: Methods and compositions for identifying and isolating sperm cells from samples containing multiple cell types are described. The methods and compositions employ antibodies that specifically bind to sperm-specific antigens located on or internal to the sperm plasma membrane. A reporter molecule may be conjugated to the antibodies to aid in... Agent: University Of Virginia Patent Foundation

20080318251 - Mammalian sweet and amino acid heterodimeric taste receptors: The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening... Agent: Fenwick & West LLP

20080318252 - Rapid assay to test anti-cancer drugs under physiological conditions: This invention relates to an assay that allows for the rapid determination of the activity of a given drug against leukemic cells either taken from a patient or derived from a cell line. The assay is performed in the presence of whole blood or serum.... Agent: University Of Medicine And Dentistry Of New Jersey Office Of Patents And Licensing

20080318255 - Fluorescent labeled sphingosines: The present invention relates to a method (assay) for determining the activity of an enzyme selected from the group consisting of a sphingosine kinase and a phosphatase involved in the sphingolipid pathway by use of a labeled sphingosine.... Agent: Novartis Institutes For Biomedical Research, Inc.

20080318256 - Method for stabilizing coenzyme and composition therefor: Disclosed is a sugar and/or a sugar alcohol as a substance for suppressing dephosphorylation reaction of a phosphorylated coenzyme. Also disclosed is a method for stabilizing a phosphorylated coenzyme which is characterized by having at least a substance for suppressing dephosphorylation reaction of the phosphorylated coenzyme coexist with the phosphorylated... Agent: Greenblum & Bernstein, P.L.C

20080318249 - Methods and reagents to increase the sensitivity of enzyme metallographic detection: A test agent includes a composite probe having at least one nanoparticle having multiple metal atoms, a directing agent, and an enzyme. The directing agent attaches the probe to a target in a test sample. The test sample and bound probe are then treated with an enzyme substrate. A method... Agent: Alix Yale & Ristas LLP

20080318257 - Polynucelotides encoding novel variants of the trp channel family member, ltrpc3: The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h,... Agent: Louis J. Wille Bristol-myers Squibb Company

20080318258 - Method for measuring cholesterol in remnant-like lipoprotein: A method for measuring cholesterol in remnant-like lipoprotein, the method comprising subjecting a test sample containing lipoproteins to the action of a cholesterol esterase and a cholesterol oxidase or cholesterol dehydrogenase, and measuring the hydrogen peroxide or reduced coenzyme generated by the enzymatic reaction, wherein a surfactant having a benzenesulfonic... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080318259 - Hematocrit and analyte concentration determination: A method to determine an analyte concentration of an anticoagulated plasma by performing at least two different measurements on a mixture of a blood sample corresponding to said anticoagulant plasma and of liquid reagent is described. The method comprises a) mixing a volume of said blood sample with a five-fold,... Agent: Bacon & Thomas, PLLC

20080318260 - Methods and apparatus for measuring blood coagulation: The present invention provides apparatus and methods for performing assays for determining the time required for a sample of blood to coagulate. The apparatus comprises reaction chambers coated with one or more clotting agent. A drop of blood or equivalent is placed at the sample application port, diluted, and contacted... Agent: Fenwick & West LLP

20080318264 - Biomarkers associated with age-related macular degeneration: The invention relates to proteins associated with age-related macular degeneration (AMD). These proteins, which are present in blood, are expressed in individuals with AMD at either elevated or reduced levels compared to healthy individuals. The invention provides methods for diagnosing AMD. The invention provides methods for assessing the efficacy of... Agent: Townsend And Townsend And Crew, LLP

20080318263 - Method of identifying cancer biomarkers and cancer progression: An efficient method for identifying important cancer biomarkers and identifying progression of bladder cancer using pro-u-PA as a clinical tool is provided. Searching for biomarkers critical for bladder carcinoma diagnosis and prognosis, secreted proteomes of highly malignant U1 and pre-malignant U4 cell lines are first analyzed. Proteins in the cultured... Agent: Sinorica, LLC

20080318262 - Protein cleavage at aspartic acid using chemical reagents: The present invention relates to the methods of identifying and quantifying polypeptides in a given sample by mass spectrometric analysis. More specifically, the invention provides the methods for sample preparation for proteomic analysis: the methods for the fragmentation of proteins into peptides with the specific cleavage rule (cleavage at amino-terminal... Agent: LexyoumeIPGroup, LLC

20080318266 - Fluorescence polarization instruments and methods for detection of exposure to biological materials by fluorescence polarization immunoassay of saliva, oral or bodily fluids: The inventive subject matter relates to a method for detecting the presence of a biological substance of interest in a test sample of saliva or oral fluid, comprising combining said test sample with a fluorescence-labeled ligand to said biological substance and detecting a change in the fluorescence polarization of said... Agent: Naval Medical Research Center Office Of Counsel (code 00l)

20080318265 - Measuring the thickness of organic samples: This invention relates to a quality control method for improving histoprocessing, as well as a device for measuring the thickness of an organic tissue sample suited for use in the method.... Agent: Marshall, Gerstein & Borun LLP

20080318267 - Methods and compositions for ultra-high throughput screening of natural products: The present invention provides cells having more than two drug resistance genes and at least two different resistance genes that have been recombined into the chromosome of a cell. It also teaches the processes for preparing cells by recombining two or more different drug resistance genes into the chromosome of... Agent: K&l Gates LLP

20080318269 - devices and methods for the analysis of biofilm: This invention is a diagnostic plate that can be used to select antibiotic combinations with efficacy against microorganisms growing as a biofilm. The plate allows growth of biofilm on a plurality of projections, and the subsequent simultaneous challenge of biofilms on all projections of the plate to independent concentrations and... Agent: William J Bundren The Law Office Of William J Bundren

20080318268 - Devices and methods for the selection of agents with efficacy against biofilm: This invention is a diagnostic plate that can be used to select antibiotic combinations with efficacy against microorganisms growing as a biofilm. The plate allows growth of biofilm on a plurality of projections, and the subsequent simultaneous challenge of biofilms on all projections of the plate to independent concentrations and... Agent: William J Bundren The Law Office Of William J Bundren

20080318270 - Masking background fluorescence and luminescence in the optical analysis of biomedical assays: In a process for the quantitative optical analysis of fluorescently labelled biological cells 5, a cell layer on a transparent support at the bottom 2 of a reaction vessel 1 is in contact with a solution 3 containing the fluorescent dye 4. The sensitivity of analytical detection can be considerably... Agent: Norris, Mclaughlin & Marcus, Pa

20080318272 - Gene encoding methylated catechin synthase:

20080318273 - Mutant proteinase with reduced self-cleavage activity and method of purification: The present invention provides a mutant 27 kDa NIa proteinase having reduced self-cleavage activity relative to the self-cleavage activity of its wild-type proteinase. The mutant has the same substrate cleavage activity as the wild-type proteinase but is more stable than the wild-type proteinase. The present invention also provides a method... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080318271 - Subtilases: The present invention relates to novel JP170 like subtilases from wild-type bacteria, hybrids thereof and to methods of construction and production of these proteases. Further, the present invention relates to use of the claimed subtilases in detergents, such as a laundry or an automatic dishwashing detergent.... Agent: Novozymes North America, Inc.

20080318274 - Methods and compositions for combinatorial-based production of multivalent recombinant antigens: The present invention provides methods and compositions for rapidly producing multivalent recombinant vaccines using filamentous fungal heterokaryons. The present invention relies on the use of filamentous fungal heterokaryons that are generated from combinations of two or more parent strains into which recombinant DNA molecules encoding variants of antigens derived from... Agent: Morrison & Foerster LLP

20080318275 - Hepatitis c virus asialoglycoproteins: Two Hepatitis C Virus envelope proteins (E1 and E2) are expressed without sialylation. Recombinant expression of these proteins in lower eukaryotes, or in mammalian cells in which terminal glycosylation is blocked, results in recombinant proteins which are more similar to native HCV glycoproteins. When isolated by GNA lectin affinity, the... Agent: Novartis Vaccines And Diagnostics Inc.

20080318276 - Human coagulation factor vii variants: The invention concerns novel coagulation factor VII variants, wherein the Phe residue in position 374 of SEQ ID NO 1 has been replaced by another amino acid residue which can be encoded by nucleic acid constructs and, optionally, wherein at least one other amino acid residue in the remaining positions... Agent: Novo Nordisk, Inc. Intellectual Property Department

20080318277 - Expression of human milk proteins in transgenic plants: The invention is directed to seed and seed extract compositions containing levels of a human milk protein between 3-40% or higher of the total protein weight of the soluble protein extractable from the seed. Also disclosed is a method of producing the seed with high levels of extractable human milk... Agent: Perkins Coie LLP

20080318278 - Ammonia-specific 5'-xmp aminase mutant: Disclosed herein are ammonia-specific 5′-XMP aminase mutants and a method for preparing the same. A mutation is introduced into the active site of glutamine-dependent catalysis in 5′-XMP aminase. The resulting 5′-XMP aminase mutant is devoid of the glutamine-dependent activity and specifically reacts with external ammonia in converting 5′-XMP into 5′-GMP.... Agent: Lucas & Mercanti, LLP

20080318279 - Apparatus and method for purification of nucleic acids by phase separation using laser and beads: An apparatus and method for purification of nucleic acids of cells or viruses are provided. The nucleic acid purification apparatus includes: a cell lysis capillary having a sample inlet through which samples and magnetic beads are introduced; a vibrator attached to the capillary and mixing the samples and the magnetic... Agent: Cantor Colburn, LLP

20080318280 - Cover for an array of reaction vessels for one-step operation modus: The present invention relates to means for covering one or more sample(s) that are suitable to avoid or minimize evaporation and/or condensation of any vaporizable substance that may be present in the sample(s) or reaction mixture(s), in particular evaporation of substance at the fringes of a vessel or an array... Agent: King Spalding LLP

20080318282 - Nucleic acid amplification method: Provided is a simple and highly sensitive nucleic acid amplification method including hybridizing two types of oligonucleotide probes with a target gene and ligating the oligonucleotide probes with DNA ligase and amplifying the resultant single-stranded oligonucleotide in accordance with LAMP.... Agent: Reed Smith LLP Suite 1400

20080318281 - Thermostabillization of dna polymerase by protein folding pathway from a hyperthermophile archaeon, pyrococcus furiosus: The present invention relates to maintaining the activity and stability of enzymes and biologically active proteins at increased temperatures by contacting same with a combination of isolated passive and active chaperones from a hyperthermopilic Archaeon, wherein the chaperones may include heat shock proteins, prefoldin and/or chaperonin proteins.... Agent: Moore & Van Allen PLLC

20080318283 - Fermentation process for continuous plasmid dna production: A continuous process is described for the production of microbial plasmid DNA for use in biopharmaceutical and biotechnological applications. The process consists of: first growing microbial cells containing a plasmid at a reduced temperature in a continuous stage; followed by a second plasmid induction continuous culture stage with an increased... Agent: Brooks Kushman P.C.

20080318284 - Processes for producing a fermentation product: The present invention relates to processes for producing a fermentation product comprising (a) saccharifying starch-containing material below the initial gelatinization temperature in the presence of i) from 0.001-50 AGU/g DS, preferably 0.01 to 10 AGU/g DS alpha-glucosidase activity more than the native amount of endogenous alpha-glucosidase present in the starch-containing... Agent: Novozymes North America, Inc.

20080318211 - Color-encoding and in-situ interrogation of matrix-coupled chemical compounds: Disclosed is a method for the physico-chemical encoding of a collection of beaded resin (“beads”) allowing determination of the chemical identity of bead-anchored compounds, following identification of beads bearing compounds of interest in an assay, by in-situ interrogation of individual beads, which does not require isolation of the beads of... Agent: Eric P. Mirabel

20080318254 - Psca antibodies and hybridomas producing them: The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.... Agent: Townsend And Townsend And Crew, LLP

20080318253 - Psca prostate stem cell antigen and uses thereof: The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.... Agent: Townsend And Townsend And Crew, LLP

20080318261 - Small volume in vitro analyte sensor: A sensor designed to determine the concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a redox mediator that acts as an electron transfer agent between the analyte and the electrode. A second electron transfer agent,... Agent: Bozicevic, Field & Francis LLP

20080318285 - Method of producing meningococcal meningitis vaccine for neisseria meningitidis serotypes a, c, y, and w-135: Methods for producing quadrivalent meningococcal meningitis polysaccharide and conjugate vaccines for sero types A, C, Y and W-135 disclosed. Neisseria meningitidis fastidious medium was designed to maximize the yield of capsular polysaccharides and generate minimal cellular bio mass and endotoxin in a short duration of fermentation. The crude polysaccharides are... Agent: Jeeri R. Reddy

20080318287 - Fermentative production of organic compounds using substances containing dextrin: t

20080318286 - P1-35 expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080318288 - Enzymatic reduction for producing optically active alcohols: e

20080318289 - Fermentation processes for the preparation of tacrolimus: The present invention relates to improved fermentation processes for the preparation of tacrolimus or a salt or derivative thereof by culturing a microorganism capable of producing tacrolimus or a salt or derivative thereof under submerged aerobic conditions with fed-batch processing at a high aeration rate.... Agent: Ranbaxy Inc.

20080318290 - Novel aldolase and production process of substituted alpha-keto acids: 4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxalacetic acid) by using a novel aldolase derived from the genus Pseudomonas, Erwinia, Flavobacterium, or Xanthomonas.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080318291 - Corn and fiber refining: Plant materials such as corn kernels which contain starch and fiber comprising cellulose, hemicellulose, lignin, and pectin are refined. The starch, cellulose, hemicellulose, and pectin are converted to sugars which are then fermented to ethanol. Additional sources of starch and fiber are optionally added to the refining process to further... Agent: Philip L Bateman

20080318292 - Methods of generating protein variants: The present invention provides methods of designing and generating polypeptide variants that have altered properties compared to a parent polypeptide. The present invention further provides a computer program product for carrying out the design of a variant polypeptide. The present invention further provides nucleic acids encoding enzyme variants, as well... Agent: Bozicevic, Field & Francis LLP

20080318293 - Sulfotransferase inhibitors: wherein R1, R2 and R5 each independently represents SO3− or H, and at least one of them represents SO3−; R3 represents H, acetyl or SO3−; R4 represents H, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted... Agent: Sughrue-265550

20080318294 - Biomolecular hybrid material and process for preparing same and uses for same: Disclosed is a composition and method for fabricating novel hybrid materials comprised of, e.g., carbon nanotubes (CNTs) and crosslinked enzyme clusters (CECs). In one method, enzyme-CNT hybrids are prepared by precipitation of enzymes which are subsequently crosslinked, yielding crosslinked enzyme clusters (CECs) on the surface of the CNTs. The CEC-enzyme-CNT... Agent: Battelle Memorial Institute Attn:IPServices, K1-53

20080318295 - Ketoreductases and uses thereof: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of... Agent: Dechert, LLP

20080318296 - Mutant glycoprotein resistant to modification with asparagine-linked sugar chain: To obtain a mutant protein of an asparagine-linked glycoprotein, which has no N-linked sugar chain under ordinary circumstance, and remains a physiological activity of the glycoprotein before the mutation was introduced, at least one of the amino acids contained in the amino acid sequence motif (I) and/or (II) in the... Agent: Knobbe Martens Olson & Bear LLP

20080318297 - Inhibition of infiltration, and cell killing agent: As suppressor of binding between selectin binding sugar chain and selectin or cell killing agent, (1) siRNA suppressing expression of genes which relates to cell surface antigen CD43 and selectin ligand sugar chain by RNA interference; (2) an inhibitor of sugar chain synthesis such as analogue of substrates in sugar... Agent: Drinker Biddle & Reath (dc)

20080318299 - Isolated human cell, method for obtaining the same and their use: A novel cell suited for mass production of Hemagglutinating Virus of Japan (HVJ), a method for obtaining the cell and use of the cell are disclosed. The human cell is originated from a transformed human kidney cell line, the doubling time thereof in logarithmic growth phase in suspension culture in... Agent: Law Office Of Michael A. Sanzo, LLC

20080318298 - Uncoupling of dna insert propagation and expression of protein for phage display: The present invention provides an advance in phage display technology by permitting the uncoupling of the propagation of phages containing inserted sequences encoding heterologous polypeptides from the expression of said polypeptides. The invention provides phage constructs and methods for their use to permit phage coat protein expression, and thus phage... Agent: Jones Day

20080318300 - Method for inactivating viruses with slightly acidic arginine: The present invention provides a method for conveniently producing a protein formulation in which viruses are inactivated, without impairing the quality of the obtained protein formulation, characterized by including the step of exposing the protein formulation contaminated with the viruses to a 0.1-2M aqueous solution of arginine, an arginine derivative,... Agent: Cermak & Kenealy LLP Acs LLC

20080318301 - Methods for preparing cells and viruses: Methods for preparing cells and viruses such as poxviruses are provided herein.... Agent: Leydig, Voit & Mayer, Ltd.

20080318302 - Pcb-degrading recombinant bacterium, product for the bioremediation and method of bioremediation: A recombinant bacterium capable to completely degrade or mineralize pollutants such as polychlorobiphenyls (PCBs), which corresponds to Wautersia eutropha strain JMS34, deposited under the access number NRRL B-30817 a product for the bioremediation of environments contaminated with PCBs, where the product includes a bacterial inoculum of this recombinant strain and... Agent: Hasse & Nesbitt LLC

20080318303 - Anaerobic microbial composition and methods of using same: A microbial composition for concurrent dechlorination of a mixture of chlorinated ethanes and chlorinated ethenes includes a isolated consortium of bioremediative microorganisms comprising strains of microorganism comprising Clostridium, Acetobacterium, Dehalobacter, Bacteroides, and Proteobacteria. The composition may also include Methanomicrobia.... Agent: Office Of The Staff Judge Advocate U.s. Army Medical Research And Materiel Command

20080318304 - Cultivation of micro-algae and application to animal feeds, environments, field crops, and waste treatment: The present disclosure concerns producing a micro-algae product. In preferred embodiments, the method comprises collecting urine from lactating cows, mixing the collected urine with aerobically digested cow manure to form a mother liquor, fermenting the mother liquor in an algae growth tank; and forming two distinct layers of top water,... Agent: Law Offices Of Timothy Brisson

20080318305 - In situ heat induced antigen recovery and staining apparatus and method: An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do... Agent: Dunlap Codding, P.C.

20080318306 - Device for supplying blood tubes to a whole blood analyser: A device including a pre-analytical module provided with at least one tube stirrer for homogenizing blood and preventing clot formation and disposed on a line for single-tube transfer between an area for storing analyzable tubes, and at least one unitary operating whole blood analyzer and automatic tube-loading/unloading device arranged between... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080318307 - Incubation condition monitoring device: An incubation condition monitoring device has at least one reader unit (10) to measure selected characteristics with an incubator (2). The reader unit transmits the information to a receiver/transmitter (12) within the incubator to receive the measurements and to transmit the measurements of the selected characteristics to a data logger... Agent: Brinks Hofer Gilson & Lione/chicago/cook

20080318308 - Aerating organic matter container: The present invention consists of a container of arbitrary size, shape, and density configured with ventilating holes of arbitrary size, shape, and distribution to promote air circulation and drainage. In some variations of the present invention a hinged rotatable cover or a supported removable cover prevents the entry of rain... Agent: John Alfred Hinchey

20080318309 - Submerged membrane bio-reactor: A submerged membrane bio-reactor (MBR) is provided. The submerged MBR includes a submerged membrane module having a membrane with a hollow fiber structure, a cylindrical tube covering an outer circumference of the submerged membrane module, and a nozzle or a porous diffuser provided within a treatment vessel to supply air... Agent: Larson And Larson

20080318310 - Method and apparatus for automatically isolating microbial species: This invention relates to an apparatus for streaking a sample on a media-coated (agar) plate in a predefined pattern utilizing a plate carousel system to house and retrieve a plate to a fixed location, a streaking mechanism having a floating stylus having a tip capable of gliding over the agar... Agent: Merck And Co., Inc

20080318311 - Encapsulated bacteriophage formulation: An encapsulated bacteriophage formulation and a method for preparing encapsulated bacteriophage formulation is provided. The method for producing the encapsulated bacteriophage composition involves injection of a molten coating substance comprising stearic acid and palmitic acid present at a ratio of 50:50, into a granulator chamber containing immobilized bacterio-phages. The immobilized... Agent: Brinks, Hofer, Gilson & Lione

20080318312 - Pancreatic islet transcription factor and uses thereof: The present invention provides a pancreatic islet transcription factor and methods of treating and diagnosing diabetes.... Agent: Townsend And Townsend And Crew, LLP

20080318313 - Method to prevent graft rejection using tgf-beta to induce t suppressor cells: The invention relates to compositions and methods useful for preventing graft rejection in a recipient following organ transplantation.... Agent: Morgan, Lewis & Bockius, LLP

20080318314 - Production from blood of cells of neural lineage: A method including in vitro stimulating a core cell population (CCP) of at least 5 million cells that have a density of less than 1.072 g/ml, and at least 1.5% of which are CD34+CD45−/dim, to differentiate into a neural progenitor/precursor cell population (NPCP). Other embodiments are also described.... Agent: Cooper & Dunham, LLP

20080318316 - Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same: A method is provided for controlling the survival, proliferation, and/or differentiation of hepatic progenitors in vitro by using specific types of mesenchymal feeder cells or one of more of the paracrine signals produced by those feeders.... Agent: Foley And Lardner LLP Suite 500

20080318315 - Reverse-flow perfusion of three-dimensional scaffolds: The invention is a reverse-flow method and system for the loading, proliferation and differentiation of cells into and throughout an implantable biocompatible three-dimensional scaffold.... Agent: The Nath Law Group

20080318317 - Kit for preparing a composition comprising fat cells: A kit for preparing a composition including fat cells includes: a) at least one sterile tube (1) adapted to be centrifuged, including a body (11) and a plug (12) including an element made of elastic and retractable material, the body (11) being hermetically sealed by the plug (12), the plug... Agent: Young & Thompson

20080318318 - Filler-dispersed melt-kneaded products, molded resin products thereof, and production method thereof: A melt-kneading method for filling material-containing resin or elastomer includes: a step of preparing a filling material as a filler and a resin or elastomer comprising an incompatible blend; and a step of introducing the filling material-containing resin or elastomer into a material feed part provided at an end of... Agent: K.a. Patents

20080318319 - Novel method of nucleic acid transfer: m

20080318320 - Targeting vector to the urokinase plasminogen activator receptor: The present invention relates to the targeted delivery of a delivery vehicle construct which specifically binds to and stimulates endocytosis into cells expressing the urokinase plasminogen activator receptor (uPAR), and particularly human airway epithelia. The delivery vehicle construct comprises a portion of uPA and a cargo linked thereto and is... Agent: Mckee, Voorhees & Sease, P.L.C

20080318321 - Methods for generating hypermutable microbes: Bacteria are manipulated to create desirable output traits using dominant negative alleles of mismatch repair proteins. Enhanced hypermutation is achieved by combination of mismatch repair deficiency and exogenously applied mutagens. Stable bacteria containing desirable output traits are obtained by restoring mismatch repair activity to the bacteria.... Agent: Banner & Witcoff, Ltd.

20080311552 - Use of sirnas in organ storage/reperfusion solutions: The invention is the modification of organs, tissues and cells with a storage/reperfusion solution comprising siRNAs specific for genes whose expression is associated with loss of viability or cell damage. The presence of siRNAs in the storage/reperfusion solution minimizes and/or prevents organ, tissue and cell damage such that the organs,... Agent: Knobbe Martens Olson & Bear LLP

20080311553 - Perfusion and/or preservation solution for organs: The present invention relates to a solution for preservation, perfusion, and/or reperfusion of an organ, especially the heart, for transplantation. The solution contains peptide inhibitor(s) of protein kinase C βII (PKC βII) and/or of protein kinase C ζ (PKC ζ) and/or peptide activator(s) of protein kinase C δ (PKCδ). Methods... Agent: Blank Rome LLP

20080311555 - In vitro root-nematode assay in multi-well plates: The invention provides an improvement in the method of screening roots, both transgenic and non-transgenic, for activity against parasitic nematodes. In particular, the improvement of the invention is use of multi-well cell culture plates for root culture and nematode infection steps.... Agent: Basf Corporation

20080311554 - Methods for monitoring patients with severe sepsis and septic shock and for selecting treatments for these patients: Methods of identifying, monitoring and matching patients with appropriate treatments who are at risk for developing a systemic inflammatory condition using a systemic mediator-associated physiologic test profile are provided. The methods of the present invention increase the likelihood of demonstrating clinical efficacy in clinical trial datasets.... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20080311559 - Detection of nucleic acids from multiple types of human papillomaviruses: Nucleic acid oligonucleotide sequences are disclosed which include amplification oligomers and probe oligomers which are useful for detecting multiple types of human papillomaviruses (HPV) associated with cervical cancer. Methods for detecting multiple HPV types in biological specimens by amplifying HPV nucleic acid sequences in vitro and detecting the amplified products... Agent: Gen Probe Incorporated

20080311557 - Device, kit and method for hookworm antigen capture and detection: A device, kit and method for detecting the presence or absence of hookworm antigens. The device, kit and method of the present invention may be used to confirm the presence or absence of hookworm in a fecal sample that may be infected with one or more of roundworm, whipworm, tapeworm... Agent: Chris A. Caseiro

20080311561 - Kits and method for detecting human papilloma virus with oligo nucleotide bead array: Provided are determining methods of human papillomavirus (HPV) genotypes with a high sensitivity. The method includes performing two-step PCRs on an HPV L1 gene in a sample to be analyzed as a biotin-labeled, single-stranded L1 gene, performing a hybridization reaction on the biotin-labeled, single-stranded L1 gene with a HPV genotype... Agent: Casimir Jones, S.c.

20080311558 - Methods for rapid identification of pathogens in humans and animals: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or... Agent: Casimir Jones, S.c.

20080311560 - Oligonucleotides for detecting human papilloma virus in a test sample: Oligonucleotides targeted to HPV Type 16 and/or Type 18 nucleic acid sequences which are particularly useful to aid in detecting HPV type 16 and or 18 are described. The oligonucleotides can aid in detecting HPV Type 16 and/or Type 18 in different ways such as by acting as hybridization assay... Agent: Gen Probe Incorporated

20080311556 - Sense antiviral compound and method for treating ssrna viral infection: The invention provides sense antiviral compounds and methods of their use in inhibition of growth of viruses of the Flaviviridae, Picornoviridae, Caliciviridae, Togaviridae, Coronaviridae families and hepatitis E virus in the treatment of a viral infection. The sense antiviral compounds are substantially uncharged morpholino oligonucleotides having a sequence of (12-40)... Agent: King & Spalding LLP

20080311570 - Cancer screening method: A method for screening cancer comprises the following steps: (1) providing a test specimen; (2) detecting the methylation state of the CpG sequence in at least one target gene within the genomic DNA of the test specimen, wherein the target genes is consisted of SOX1, PAX1, LMX1A, NKX6-1, WT1 and... Agent: Wpat, PC Intellectual Property Attorneys

20080311583 - Chromosome manipulation method: A universal method for chromosome modification (deletion of a desired DNA region) which does not require any special enzymes or sequences is provided. Further, a method for determining whether the DNA region to be deleted contains a gene essential for growth of the cell under certain culture conditions is provided... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080311568 - Compositions and methods for nucleic acid analysis of sequences with insertions or deletions: Contemplated methods and kits include a plurality of single stranded oligonucleotides that comprise a discriminating sequence that is encompassed on one end by a label and on the other end by a unique tag sequence. In one preferred aspect, the discriminating sequence is an RNA repeat unit, forms a heteroduplex... Agent: Fish & Associates, PC Robert D. Fish

20080311573 - Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080311581 - Functional polymorphisms of the interleukin-1 locus affecting transcription and susceptibility to inflammatory and infectious diseases: The invention provides methods and reagents for detecting a polymorphism associated with in an upstream region of the interleukin-1β (IL-B) gene (IL-1B (−3737)) that affects transcription of the gene and susceptibility to inflammatory and infectious diseases such as diffuse coronary artery disease.... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris,

20080311579 - Hybridisation beacon and method of rapid sequence detection and discrimination: A method for detecting specific DNA sequences and discriminating single nucleotide polymorphisms (SNPs) using fluorescently labelled oligonucleotide probes is disclosed. Oligonucleotide probes are labelled with reporter molecules preferentially attached to an internal nucleotide residue. The fluorescence emission of oligonucleotide probes varies significantly when in single-stranded and double-stranded states despite the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080311586 - Method for measuring in vivo hematotoxicity with an emphasis on radiation exposure assessment: The present invention relates a method for assessing in vivo hematotoxicity. The method utilizes differential staining of nucleated and non-nucleated blood cells, and also differential labeling of cells with functional versus dysfunctional mitochondrial membrane potential. Quantitative analyses can be conducted on stained whole blood specimens, and is based on blood... Agent: Nixon Peabody LLP - Patent Group

20080311566 - Method for quantification of methylated dna: The present invention relates to a method for the quantification of methylated cytosines in DNA. In the first step of the invention unmethylated cytosines in the DNA to be analysed are chemically converted into uracil while 5-methylcytosines remain unchanged. In a second step the converted DNA is amplified methylation specifically... Agent: Kriegsman & Kriegsman

20080311569 - Method for quantitative measurement of gene expression for indentifying individuals at risk for bronchogenic carcinoma: A method measure expression of multiple target genes in a progenitor cell for bronchogenic carcinoma comprising the use of reverse transcription-polymerase chain reaction (RT-PCR) to allow simultaneous expression measurement of the multiple target genes is disclosed.... Agent: Wilson Sonsini Goodrich & Rosati

20080311577 - Method for the identification of sulfo-oxidizing bacteria and for the monitoring of elemental sulfur in the environment: A method is described for the identification of sulfooxidizing bacteria comprising the extraction of the DNA from environmental samples and the subsequent identification of at least one fragment of the Thio 16S gene or SoxB gene present in these bacteria. The method can be used for determining the level of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080311572 - Methods and compositions for correlating ccl3l1/ccr5 genotypes with disorders: The present invention provides compositions and methods for identifying persons at an increased risk of infection by, transmission of, or accelerated progression of a disease caused by an HIV-1 virus. Diagnostic and therapeutic kits are also provided.... Agent: Myers Bigel Sibley & Sajovec

20080311565 - Methods and kits for detecting germ cell genomic instability: Disclosed are methods for detecting microsatellite instability in the germ line of males, methods of assessing risk for developing testicular cancer, methods of evaluating the microsatellite stability of putative cancer or precancerous cells or a tumor, methods for evaluating germ cells for exposure to mutagens, and kits for use in... Agent: Michael Best & Friedrich LLP

20080311584 - Methods for detection of mutations in myostatin variants: Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a predisposition for increased muscle mass as compared to subjects having wild-type myostatin. Increased muscle mass is particularly desirable for identification of animals used to... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP

20080311563 - Methods for selecting medications: Methods for selecting a medication for a patient are described that include determining the patient's genotype for a panel of genes and selecting the medication based on the genotype. Articles of manufacture also are provided that include nucleic acid molecules for detecting alleles of genes encoding drug metabolizing enzymes and... Agent: Fish & Richardson P.C.

20080311582 - Methods using pores: The invention relates to a method of identifying an individual nucleotide, comprising (a) contacting the nucleotide with a transmembrane protein pore so that the nucleotide interacts with the pore and (b) measuring the current passing through the pore during the interaction and thereby determining the identity of the nucleotide. The... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080311575 - Modulation of muci-dependent anti-estrogen resistance: The present invention provides methods for identification and use of compounds that modulate the association of MUC1 with estrogen receptors and thereby antagonize MUC1-related resistance to anti-estrogen treatment.... Agent: Fulbright & Jaworski L.L.P.

20080311580 - Novel genes encoding proteins involved in proanthocyanidin synthesis: e

20080311574 - Novel missense mutations and single nucleotide polymorphisms in the rabphillin-3a-like gene and uses thereof: The invention relates to methods and compositions of matter for determining or predicting aggressiveness of a subject's tumor, for determining a subject's predisposition to cancer, for diagnosing cancer in a subject, and for selecting a therapy for a subject with cancer. Also provided are methods and compositions of matter for... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20080311571 - Nucleic acid fragments for detecting nucleic acid and method for detecting nucleic acid: A nucleic acid fragment set according to the present invention comprises a plural number of nucleic acid fragments capable of individually hybridizing with a plural number of target sequences, in which each nucleic acid fragment has a region ligatable with each other and the affinity between such ligatable regions is... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080311562 - Nucleic acid sequencing: n

20080311576 - Replication competent hepatitis c virus and methods of use: The present invention provides a replication competent hepatitis C virus that includes a heterologous polynucleotide. The invention also includes methods for modifying a hepatitis C virus polynucleotide, selecting a replication competent hepatitis C virus polynucleotide, detecting a replication competent hepatitis C virus polynucleotide, and identifying a compound that inhibits replication... Agent: Mueting, Raasch & Gebhardt, P.A.

20080311564 - Sequences and methods for detection of cytomegalovirus: Amplification primers and methods for specific amplification and detection of a CMV target are disclosed. The primer-target binding sequences are useful for amplification and detection of the CMV target in a variety of amplification and detection reactions.... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20080311585 - System and method for multiplex liquid handling: The present invention generally relates to microfabricated devices for carrying out and controlling chemical reactions and analysis. In particular, the present invention provides systems, methods, devices and computer software products related to multiplex liquid handling systems utilizing lab cards related to biological assays.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20080311578 - System for screening eukaryotic membrane proteins: The present invention provides methods and compositions for expressing eukaryotic membrane proteins.... Agent: Ropes & Gray LLP

20080311567 - Tumor markers for use in the diagnosis of colorectal carcinomas and/or metastases originating therefrom: The invention relates to a method (i) for detecting a carcinoma, especially an adenocarcinoma, preferably a gastrointestinal carcinoma and more preferably a colorectal carcinoma, (ii) for predicting metastases, preferably liver metastases, depending on a primary colon carcinoma and/or (iii) for predicting the response of metastases to a 5-fluorouracil-containing chemotherapy. The... Agent: Siemens Corporation Intellectual Property Department

20080311587 - Use of genetic information to detect a predisposition for bone density conditions: The invention relates to kits and methods for assessing susceptibility of a human to an undesirable bone density condition, such as osteopenia and osteoporosis, and advising appropriate interventions. The methods involve contemporaneously assessing occurrence in the human's genome of a plurality of polymorphisms (e.g., single nucleotide polymorphisms) that occur in... Agent: Brandy C Hill

20080311589 - Method of high-throughput screening of molecules and compounds for their effects on biological and chemical processes: The present invention provides a system for high-throughput analysis of chemical compounds. Assays are performed in a high density platform, and compounds having pre-determined desirable effects are identified. Preferably, the compounds have biological effects, more preferably, the assays and detection are performed on whole cells.... Agent: Choate, Hall & Stewart LLP

20080311588 - Neurogenin: The invention relates to novel neurogenin proteins, nucleic acids and antibodies.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080311590 - Portable materials and methods for ultrasensitive detection of pathogen and bioparticles: The present invention provides systems for ultrasensitive detection of pathogens and bioparticles. One embodiment of the system comprises an optical detection scheme that allows for the detection of the fluorescence signal of bacteria or other bioparticles in less than about 20 minutes. A microflow channel allows for an assay probing... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080311593 - Methods of diagnosing non-alcoholic steatohepatitis (nash): Non-invasive methods for detecting non-alcoholic fatty liver disease (NAFLD) and identifying the presence or absence of non-alcoholic steatohepatitis (NASH) in a subject utilize one or more biomarkers. The methods can differentiate between subjects with NASH and those with simple steatosis. Kits containing one or more agents for measuring the level... Agent: Kilyk & Bowersox, P.l.l.c.

20080311594 - Use of fibroblast growth factor 7 (fgf7) and of the receptor fgfr2b as biomarkers: n

20080311595 - Rapid fungal detection assay and product: The present invention relates to the use of an assay and product for rapid detection of fungi in a variety of samples suspected of containing fungi, particularly swab samples from the human vaginal area, but also in other environments such as in food and feeds. The product of the invention... Agent: Lynn E Barber

20080311596 - Genes of porphyromonas gingivalis w83 involved in invasion of human cells: Compositions and methods are provided for detection and treatment of Porphyromonas gingivalis infection.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080311597 - Modified cardiolipin and uses therefor: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, oxidized cardiolipins, which may be conjugated with a variety of attachment molecules, such as BSA, KLH, biotin, synthetic protein MAPS, IgY, streptavidin, or avidin, are described. Such oxidized... Agent: Klarquist Sparkman, LLP

20080311591 - Differential immunoassay: The invention provides assay methods and kits that in general measure the level of a first analyte in a sample reduced by the level of a second analyte present in the same sample. In one embodiment, where levels of a first analyte from a first source is desirably determined and... Agent: Morgan, Lewis & Bockius LLP (sf)

20080311592 - Allosteric control of proteins by manipulating mechanical tension: A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the polypeptide, attaching a second end of the polymer to a second portion of the polypeptide, and altering the... Agent: Karen S. Canady Canady & Lortz LLP

20080311598 - Magnetic biosensor for determination of enzymic activity: Magnetic sensors are very suitable for use in determination of enzymatic activity. In a preferred embodiment the invention relates to a method for determining activity of an enzyme in modification of substrate (2) to product (3), comprising binding substrate or a binding composition that may bind e.g. substrate or product,... Agent: Philips Intellectual Property & Standards

20080311599 - Antibodies against caspase-8, their preparation and use: The invention relates to antibodies to a specific region in caspase-8, and to their use.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080311603 - Diagnostic test for inflammatory endothelial dysfunctions in pregnancies: The present invention relates to a diagnostic test for inflammatory endothelial dysfunctions in pregnant women. Particularly, the present invention relates to a method of diagnosing or evaluating the risk of contracting an inflammatory endothelial dysfunction of the maternal compartment comprising the following steps: a) detecting the plasma levels of long... Agent: Dickstein Shapiro LLP

20080311601 - Methods for prediction and prognosis of cancer, and monitoring cancer therapy: The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of VEGF as a biomarker for multi-kinase inhibitors.... Agent: Leona L. Lauder

20080311602 - Rapid elisa processes and related compositions: The present invention provides improved and rapid detection methods for an antigen such as a chemical compound, a peptide, a nucleic acid, or a protein released from cells or virus particles in situ. The detection time for an antigen can be dramatically reduced relative to conventional technologies. The technology can... Agent: Genscript Corporation

20080311600 - Roundworm coproantigen detection: A composition, device, kit and method for detecting the presence or absence of roundworm in a fecal sample. The composition, device, kit and method of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may also be... Agent: Chris A. Caseiro

20080311604 - Methods for prediction and prognosis of cancer, and monitoring cancer therapy: The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of soluble VEGF-R2 as a biomarker for multi-kinase inhibitors.... Agent: Leona L. Lauder

20080311605 - Kit and method to perform a biological test designed to evaluate minerals potential for being bioleached: A kit and method to perform a biological assay for evaluating the bioleaching potential of minerals, which allows to know the metallurgic response of minerals for geo-mining-metallurgic short and mid term planning, wherein the kit comprises a propylene tube-type container which has a line that specifies the liquid filling level,... Agent: Maria De La Luz Osses Klein Et Seq LLC

20080311606 - Platelet activation markers and predictors of desease and of response to therapy and for monitoring therapeutic progress: Methods for assessing patient risk for platelet-affected disease states are disclosed. Also disclosed are methods for predicting the appropriateness of platelet antagonist therapy, and for monitoring patients during therapeutic intervention or during a combined regimen of therapy and angioplasty.... Agent: Woodcock Washburn LLP

20080311608 - Antagonist of the oncogenic activity of the protein mdm2, and use thereof in the treatment of cancers: The present invention relates to the utilization of a compound capable of antagonizing at least partially the oncogenic activity of the protein Mdm2 for the preparation of a pharmaceutical composition intended more particularly to a treatment of cancers with no p53 context. It further relates to the viral vector comprising... Agent: Wiley Rein LLP

20080311613 - Artificial skin surface film liquids: An artificial skin surface film liquid (SSFL) is disclosed that mimics the chemical composition and biological action of both human sweat and sebum. The artificial sweat formulation contains a comprehensive combination of constituents. When combined with the sebum component it is particularly effective at modeling the effect of the skin... Agent: Klarquist Sparkman, LLP

20080311612 - Functional expression of higher plant nitrate transporters in pichia pastoris: The present invention relates to a system for functional expression of higher plant nitrate transporter (Nrt) genes in Pichia pastoris, an in vivo nitrate uptake assay using these Pichia pastoris transformants, and an assay for readily identifying successful transformants.... Agent: Pioneer Hi-bred International, Inc.

20080311610 - Method for the identification of macromolecule targets of analytes: There is provided a method for the identification of macromolecule targets of analytes such as drugs in biological samples comprising complex mixtures of macromolecules. A biological sample is contacted with one or more analyte and the mixture is resolved such that the analyte and its target are co-eluted and analyzed... Agent: Bereskin And Parr

20080311611 - Methodology for verifying carbon storage in seawater: A method for verifying carbon storage in seawater to which a growth stimulant has been supplied for stimulating a bloom of nitrogen fixing organisms for enhancing carbon storage therein, comprises selecting a region of seawater including a surface mixed layer, a euphotic zone extending below the surface mixed layer, and... Agent: Mcdermott Will & Emery LLP

20080311607 - Methods and compositions for regulation of stem cell survival, proliferation, and differentiation by protein ubiquitination: Compositions and methods for regulating in vitro cell growth are disclosed, and for providing undifferentiated stem cells or embryonic cells that are suitable for transplantation into damaged tissues or organs, or for use in tissue repair. A representative method includes causing the overexpression or underexpression of GalT binding protein (GtBP),... Agent: Conley Rose, P.C. David A. Rose

20080311614 - Methods for measuring ph in a small-scale cell culture system and predicting performance of cells in a large-scale culture system: The present invention is directed to methods/systems for measuring the pH of a cell culture medium in a small-scale system utilizing a pH-sensitive dye. The present invention is also directed to methods for predicting the performance of cells in a large-scale culture system.... Agent: Fitzpatrick Cella (wyeth)

20080311609 - Novel molecular probes: The present invention relates to novel molecular probes having the formula (I) (I) useful for the characterization, detection, localization and isolation of the γ-secretase enzyme.... Agent: Pepper Hamilton LLP

20080311616 - Hydrophilic ir transparent membrane, spectroscopic sample holder comprising same and method of using same: The present invention features hydrophilic IR-transparent porous membranes, particularly hydrophilic IR-transparent porous polyethylene membranes and methods of preparing the hydrophilic membranes by treatment of hydrophobic IR-transparent porous membranes with plasma. The present invention further features spectroscopic sample holders which incorporate the hydrophilic IR-transparent porous membranes and methods of identifying bacteria... Agent: Edwards Angell Palmer & Dodge LLP

20080311615 - Method for chiral separation of lactic acid enantiomers: A method for the separation and simultaneous determination of urinary D- and L-lactic acid enantiomers by high performance liquid chromatography tandem mass spectrometry (HPLC/MS/MS). The chiral separation was done using a chirobiotic teicoplanin aglycone column varying mobile phase parameters such as the acetic acid/triethylamine content and the aqueous/organic ratio.... Agent: E. J. Asbury Iii, Esq

20080311617 - Modified transketolase and use thereof: The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds.... Agent: Nixon & Vanderhye, PC

20080311622 - Activatable recombinant neurotoxins: Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.... Agent: Allergan, Inc.

20080311618 - Expression system, components thereof and methods of use: Recently, the development of inducible expression systems has involved exploitation of the p-cym operon from Pseudomonas putido. Disclosed herein are novel expression systems and components thereof, which involve the development of CymR variants with reverse DNA binding activity, such that they exhibit increased affinity for DNA in a presence rather... Agent: Kirby Eades Gale Baker

20080311620 - Novel genes: The present invention is directed to novel genes mediating the carbon catabolite repression (CCR) of gluconeogenic genes. Furthermore, the polypeptides encoded by said genes as well as the use of said genes in a process for the production of a target fermentation product is provided. Processes for generating such microorganisms... Agent: Nixon & Vanderhye, PC

20080311621 - Polypeptides and nucleic acids encoding same: DNAs are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and... Agent: Goodwin Procter LLP Attn: Patent Administrator

20080311619 - Recombinant carboxypeptidase b: A nucleic acid coding for pro-carboxypeptidase B (Pro-CPB), comprising three segments A, B and C, wherein at least one of the segments has one of the sequences according to SEQ ID No. 1, 2 or 3.... Agent: Ohlandt, Greeley, Ruggiero & Perle, LLP

20080311623 - Plasmid system for multigene expression: The present invention provides a plasmid system which facilitates the construction of a single amplifiable plasmid that, having the potential to accommodate many independent expression cassettes, has the ability to express multi-subunit complex proteins such as antibodies and receptors.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20080311624 - Chimeric immunogens: Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory... Agent: Sim & Mcburney

20080311625 - Immortal pluripotent stem cell line, cell lines derived therefrom, methods of preparing thereof and their uses: The present invention relates to immortal pluripotent stem cells derived from a human leukaemia cell line, preferably a human monocytoid cell line and more preferably the human monocytoid cell line, THP1. The present invention further relates to cell lines derived from the immortal pluripotent stem cell line having the phenotype... Agent: Steinfl & Bruno

20080311627 - Compositions and methods for preventing carry-over contamination in nucleic acid amplification reactions: Particular aspects provide methods for the specific amplification of template DNA in the presence of potentially contaminating PCR products from previous amplification experiments, but wherein the contaminating prior reaction amplificates (carry-over contaminants) are rendered non-amplifiable, based on use of particular contaminant degradation enzymes, and use of at least one primer... Agent: Davis Wright Tremaine, LLP/seattle

20080311629 - Development of pcr primers and primer mixtures for amplification of cnp60 target sequences: We have developed the primer pair H1511 and H1261 as a replacement for primer pair H279/H280 for specific amplification of cpn60 universal target sequences in genomic DNA or in complex DNA mixtures, including those with high G+C content.... Agent: Ade & Company Inc.

20080311626 - Dna polymerases having strand displacement activity: The invention provides novel strand displacement DNA polymerases which can be used in a rapid and efficient strand displacement amplification reactions. The polymerases are significantly more thermostable than prior art polymerase and retain high activity at elevated temperatures. Also disclosed are genes encoding the polymerases and vectors comprising the genes.... Agent: Birch Stewart Kolasch & Birch

20080311628 - Methods and compositions for rapid amplification and capture of nucleic acid sequences: A method for amplifying a nucleic acid sequence includes the steps of (i) providing a first pair of primers that include one or more uracil nucleotides, the primers being complementary to a portion of a genomic template, (ii) introducing the first pair of primers, the genomic template and a first... Agent: James P. Broder Roeder & Broder LLP

20080311630 - Dna constructs for specific inhibition of gene expression by rna interference: The invention relates to expression constructs for targeted inhibition of gene expression and methods for their production and which, after transfection thereof into eukaryotic cells, are suitable for inhibiting in a targeted manner these cells formation of defined proteins by RNA interference, wherein the method is a three step method... Agent: Ursula B. Day, Esq.

20080311631 - Biosynthetic production of 4-amino 4-deoxychorismate (adc) and [3r,4r]-4-amino-3-hydroxycyclohexa-1,5-diene-1-carboxylic acid (3,4-cha): The invention relates to a process for the biosynthetic production of 4-amino-4-deoxychorismate (ADC) performed fermentatively in vivo with a 4-amino-4-deoxychorismate synthase, preferably a PabAB bipartite protein (which may be a fusion protein), at an increased level of activity, thereby obtaining a broth comprising ADC and 4-amino-4-deoxyprephenate (ADP), that are recovered.... Agent: Nixon & Vanderhye, PC

20080311632 - Methods for producing methionine by culturing a microorganism modified to enhance production of cysteine: A method of producing methionine, derivatives or precursors thereof comprising culturing a microorganism modified to enhance production of cysteine in a culture medium comprising a source of carbon and a source of sulfur and recovering methionine from the culture medium. A microorganism for fermentative production of methionine or its derivatives... Agent: Ip Group Of Dla Piper US LLP

20080311633 - Plasmid vectors for transformation of filamentous fungi: m

20080311634 - Flavonoids-rich tissue from belamcanda chinensis and methods for culturing the same: The present invention provides an in vitro flavonoid-rich tissue of Belamcanda chinensis, which is produced in a tissue culture system using a B. chinensis tissue capable of proliferation, such as a seed, an embryo of said seed, a root, a leaf, a base of a leaf, or a young inflorescence... Agent: Andrews Kurth LLP Intellectual Property Department

20080311635 - Process for the preparation of (s)(+)-3-(aminomethyl)-5-methylhexanoic acid: e

20080311636 - Method for producing optically active alpha-hydroxycarboxylic acid: An efficient method for producing an optically active α-hydroxycarboxylic acid represented by the following general formula (I) [A represents a residue of a 5- or 6-membered cyclic compound, * indicates a carbon atom in the S- or R-configuration, X represents hydrogen atom or an alkyl group having 1 to 4... Agent: Greenblum & Bernstein, P.L.C

20080311637 - Apparatus and methods for ethanol production: Apparatus and methods for ethanol production use shock waves and pulsed electric fields to increase the conversion of starch and/or cellulosic material into sugar. The shock waves or the pulsed electric fields may also control bacteria levels in the ethanol production facility. The shock waves and the pulsed electric fields... Agent: Cyr & Associates, P.A.

20080311639 - Pulsed electric field apparatus and methods for ethanol production: Apparatus and methods for ethanol production use pulsed electric fields to increase the conversion of starch and/or cellulosic material into sugar. The pulsed electric fields may also control bacteria levels in the ethanol production facility. The pulsed electric fields may be generated by a pulsed electric field generator such as... Agent: Cyr & Associates, P.A.

20080311638 - Shock wave apparatus and methods for ethanol production: Apparatus and methods for ethanol production use shock waves to increase the conversion of starch and/or cellulosic material into sugar. The shock waves may also control bacteria levels in the ethanol production facility. The shock waves may be generated by a shock wave generator that includes a pulsed electric field... Agent: Cyr & Associates, P.A.

20080311640 - Anaerobic production of hydrogen and other chemical products: Described herein are methods for producing chemical products by anaerobically fermenting a particular biomass using anaerobic bacteria. Such chemical products include hydrogen and other gases, acetic acid and other volatile organic acids, solvents, solids, and salts of volatile organic acids.... Agent: Wilson Sonsini Goodrich & Rosati

20080311641 - Crystallization of enzyme and method for producing same: The present invention provides a method of crystallizing of enzymes. The method is for rapidly crystallizing enzymes from impure mixtures. The method is simple and cheap, and it is compatible to industrial requirements. T1 lipase was able to form crystals at low protein concentration (2.5 mg/ml) in a day. High... Agent: Edwards Angell Palmer & Dodge LLP

20080311642 - Methods of purifying chondroitinase and stable formulations thereof: An aspect of the present invention relates to stable formulations of chondroitinase and to methods of purifying chondroitinase. The methods of purifying chondroitinase includes the steps of extracting the enzyme from a cell, separating the chondroitinase from the crude cell extract using cation-exchange chromatography, removing impurities through gel filtration chromatography,... Agent: Pepper Hamilton LLP

20080311643 - Novel pseudomonas aeruginosa: bacteriophage and uses thereof: The present invention is directed to isolated bacteriophage having strong lytic activity against strains of Pseudomonas aeruginosa, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth of Pseudomonas aeruginosa in various settings.... Agent: Hunton & Williams LLP Intellectual Property Department

20080311644 - Amino methylated 2-pyridinones: Novel amino methylated 2-pyridinones, precursors, intermediates, and derivatives; the methods for the preparation of the same; uses of the same for inhibiting pili formation in bacteria; and pharmaceutical compositions comprising these compounds are described in this application. The present compounds may be employed to inhibit biofilm formation and thereby inhibit... Agent: Senniger Powers LLP (wshu)

20080311645 - Method of culturing a microorganism: A method of culturing a microorganism capable of producing at least any one of a highly unsaturated fatty acid or a compound containing a highly unsaturated fatty acid as a constituent fatty acid in a culture medium containing at least a carbon source and a nitrogen source, using an aeration-agitation... Agent: Drinker Biddle & Reath (dc)

20080311646 - Carbon supply device for cultivating miro algae in large and its application method and use: Disclosed herein is a carbon supply device for supplying carbon dioxide during large scale cultivation of micro-algae in open pond, and its application method and use. The device comprises a trap container in which a partition plate is installed vertically and has a 10-50 cm gap from the container bottom,... Agent: Volpe And Koenig, P.C.

20080311647 - Method of biotreating a solid material comprising an organic compound: A method of biotreating a solid material including an organic compound is provided. According to the method, a nonstirred bioreactor having a void volume of greater than or equal to 25% with a mixture including a solid material to be biotreated and a plurality of coarse substrates having a particle... Agent: Jones Day

20080311648 - Biosensor for analyzing quantitatively analyte with a predetermined size and larger than, and manufacturing method thereof: The present invention discloses a biosensor for quantitatively analyzing a bio-material and a manufacturing method thereof. The biosensor has an exposed conductive region of a few-nanometer scale distributed on an insulated metallic substrate in a desired pattern or randomly. The quantitative analysis of protein can be carried out by means... Agent: Macpherson Kwok Chen & Heid LLP

20080311649 - Pressurized flexible tubing system for producing algae: An apparatus for producing algae circulates algae fluid through flexible reactor tubing that is at least partially translucent to sunlight. The reactor tubing lies flat when not pressurized. Preferably, the reactor tubing is made of clear polyethylene with UV inhibitors, the polyethylene being between 6 and 15 mil thick. The... Agent: Etherton Law Group, LLC

20080311650 - Bioreactor for tissue engineering: The present invention relates to a method and apparatus for growing cells in a three-dimensional scaffold. Relative movement of the scaffold and an end cap of the culture chamber results in circulation of the growth medium through the scaffold. The invention is also suited for introduction of cells into a... Agent: Joyce Von Natzmer Pequignot + Myers LLC

20080311651 - Instrumentality for sequestering liquids based on density: method and apparatus: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is... Agent: Audrey A. Millemann Weintraub Genshlea Chediak

20080311652 - Mage-c2 antigenic peptides and uses thereof: This invention relates to isolated peptides derived from MAGE-C2, nucleic acid molecules that encode MAGE-C2 and the isolated peptides derived from MAGE-C2, expression vectors comprising the nucleic acid molecules, host cells transformed or transfected with the nucleic acid molecules or the expression vectors, and to tetramers comprising the peptides, HLA... Agent: Norman D. Hanson Fulbright & Jaworski L.L.P.

20080311653 - Method and apparatus for regulating optimum flow of semen and separating motile sperms: The present invention discloses method and apparatus for regulating optimum flow of semen and separating motile sperms. The device consists of; a first cylindrical shape container, comprising a first external diameter, second external diameter, a thirds external diameter and a mesh, wherein said mesh is comprised of plurality of pores... Agent: Barry Choobin

20080311654 - Chicken leukemia inhibitory factor (lif) and gnne thereof: The present invention is to provide a chicken LIF gene. Based on this genetic information, LIF protein derived from the chicken can be stably supplied and it solves the problems of the creation of transgenic chickens in the past. In addition, the present invention provides not only transgenic chickens for... Agent: Rader Fishman & Grauer PLLC

20080311655 - Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation: Disclosed are methods for producing fusion proteins with the heterodimeric cytokine, interleukin-12. In order to insure that the proper ratio of fused and non-fused subunits are obtained in the fusion protein, a specific stepwise approach to genetic engineering is used. This consists of first expressing the non-fused p40 IL-12 subunit... Agent: Goodwin Procter LLP Patent Administrator

20080311656 - Meiosis arrest in oocytes in vitro: The method for in vitro synchronisation of nuclear and cytoplasmatic maturation of GV oocytes from domestic animals or from primates can be improved if a phosphodiesterase type 3 inhibitor is added to the medium after collection of the oocytes and, thereafter, said phosphodiesterase type 3 inhibitor is removed to allow... Agent: Novo Nordisk, Inc. Intellectual Property Department

20080311657 - Killing human lymphoma and leukemia cancer cells and tcr-activated normal human cells by dopamine d1r agonists: The dopamine D1/D5 receptor is highly over-expressed in various types of human and animal leukemia, lymphoma and activated T-cells. The dopamine D1 receptor is also expressed in dramatically elevated or even moderate levels in other types of cancer cells. Selective dopamine D1 receptor agonists, such as fenoldopam mesylate, rapidly, potently... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080311658 - Combined hairpin-antisense compositions and methods for modulating expression: A nucleotide construct comprising a nucleotide sequence that forms a stem and a loop, wherein the loop comprises a nucleotide sequence that modulates expression of a target, wherein the stem comprises a nucleotide sequence that modulates expression of a target, and wherein the target modulated by the nucleotide sequence in... Agent: Traskbritt, P.C. / Brookhaven

20080311659 - Ribonucleic acid interference molecules of oryza sativa: Sequences of ribonucleic acid interference molecules are provided. For example, in one aspect, at least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ_ID NO: 1 through SEQ_ID NO: 11,928 and one or more corresponding mature sequences having SEQ_ID NO: 11,929 through SEQ_ID... Agent: Ryan, Mason & Lewis, LLP

20080311660 - Dry powder cell culture products and methods of production thereof: The present invention relates to nutritive medium, medium supplement, media subgroup and buffer formulations. The present invention provides powder nutritive medium, medium supplement and medium subgroup formulations, e.g., cell culture medium supplements (including powdered sera such as powdered fetal bovine serum (FBS)), medium subgroup formulations and cell culture media comprising... Agent: Invitrogen Corporation C/o Intellevate

20080311661 - Ribonucleic acid interference molecules of arabidopsis thaliana: Sequences of ribonucleic acid interference molecules are provided. For example, in one aspect, at least one nucleic acid molecule comprising at least one of one or more precursor sequences having SEQ_ID NO: 1 through SEQ_ID NO: 3,197 and one or more corresponding mature sequences having SEQ_ID NO: 3,198 through SEQ_ID... Agent: Ryan, Mason & Lewis, LLP

20080305468 - Assays for preimplantation factor and preimplantation factor peptides: The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently... Agent: Pepper Hamilton LLP

20080305469 - Fluorimetric determination of analytes by an intramolecular quencher-fluorophore conjugate: A method and reagent for detecting the presence or amount of an analyte by a redox reaction and a fluorimetric determination, is disclosed. The reagent comprises a compound of the general formula Q-F as a redox indicator, wherein Q is a quencher group and F is a fluorophore group. The... Agent: Roche Diagnostics Operations Inc.

20080305467 - Generation of pulsating pressure waves, e.g. for cell lysis: The present invention relates to a method by which a controlled source of heat (preferably a laser 3) generates a pulsating vapour bubble 4 in an enclosed liquid. The pulsating rate (the frequency) is preferably in the ultrasonic region, whereby cavitation occurs in the liquid. The cavitation effect will cause... Agent: Steven Bent Foley & Lardner L.l.p

20080305490 - Amplification of human mdm2 gene in human tumors: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human... Agent: Banner & Witcoff, Ltd.

20080305483 - Biallelic markers derived from genomic regions carrying genes involved in arachidonic acid metabolism: The invention provides polynucleotides including biallelic markers derived from genes involved in arachidonic acid metabolism and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one... Agent: Frank C. Eisenchenk, Ph.d. Saliwanchik, Lloyd & Saliwanchik

20080305479 - Detection and quantification of biomolecules using mass spectrometry: The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and release labels for detection... Agent: Grant Anderson LLP C/o Portfolioip

20080305492 - Detection of gleevec resistance: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for... Agent: Klarquist Sparkman, LLP

20080305485 - Genetic marker for increased risk for obesity-related disorders: The present invention relates to methods of determining an increased risk of a subject to acquire a trait of an obesity disorder or an obesity disorder, with the method comprising determining the genetic sequence of at least one taste receptor gene in the subject and reviewing the test genetic sequence(s)... Agent: Morgan Lewis & Bockius LLP

20080305484 - Genetic methods for speciating campylobacter: Species-specific identification of campylobacters is problematic, primarily due to the absence of suitable biochemical assays for their differentiation and the existence of atypical strains. The phylogeny of twelve Campylobacter species was studied based on partial (1020-bp) gyrB gene (DNA topoisomerase beta-subunit gene) sequences. The topology of the resulting phylogenic neighbor-joining... Agent: Usda, Ars, Ott

20080305476 - Immunoassay methods: The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid from said mammalian subject wherein said antibody is a biological marker of a disease state or disease susceptibility, the... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20080305491 - Mcm6 and mcm7 monoclonal antibodies and methods for their use in the detection of cervical disease: Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics of an MCM6 or MCM7 antibody of the invention are further provided.... Agent: Alston & Bird LLP

20080305474 - Method and apparatus for using slc2a10 genetic polymorphisms for determining peripheral vascular disease in patients with type-2 diabetes: Recent data indicate that a loss-of-function mutation of the SLC2A10 gene causes arterial tortuosity syndrome (ATS) via upregulation of the TGF-β pathway in the arterial wall, a mechanism possibly causing vascular changes associated with diabetes. It is determined that SLC2A10 (Solute carrier family 2, facilitated glucose transporter, member 10) genetic... Agent: Law Offices Of Lai And Associates, P.C.

20080305472 - Method of detecting influenza bacillus, primer set for detection of influenza bacillus and kit for detection of influenza bacillus: Nucleic acid amplification is carried out using the DNA of H. influenzae as a template, and also using the LAMP primers as shown in SEQ ID NOS: 1 to 5 given as examples of the present invention. Thus, the presence or absence of the amplified product is detected. When primers... Agent: Birch Stewart Kolasch & Birch

20080305482 - Methods and compositions for nucleic acid amplification: Compositions that are used in nucleic acid amplification in vitro are disclosed, which include a target specific universal (TSU) promoter primer or promoter provider oligonucleotide that includes a target specific (TS) sequence that hybridizes specifically to a target sequence that is amplified and a universal (U) sequence that is introduced... Agent: Gen Probe Incorporated

20080305475 - Microbial community analysis: The present invention provides a method which can enhance the precision of identification of bacterial species using a T-RFLP method and achieve, by itself, the identification of bacteria constituting a bacterial flora and the tracing of distribution changes thereof. The present invention provides a method for analyzing a bacterial community... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080305489 - Near-infrared dyes as surface enhanced raman scattering reporters: e

20080305477 - Novel iminecalixarene derivatives and aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-dna by using the self-assembled monolayer, and oligo-dna chip prepared by the met: The present invention relates to novel iminecalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method. Also, the present invention relates to novel aminocalixarene derivatives, method of preparation thereof, and self-assembled... Agent: Howrey LLP-ca

20080305480 - Novel tumor marker: The present invention concerns a gene product largely homologous to the epithelial growth factor receptor (EGFR). It further refers to mRNA coding for such epithelial growth factor receptor. The present invention provides such an epithelial growth factor receptor which is characterized in that either exons 12 to 14 or exons... Agent: Fulbright & Jaworski L.L.P.

20080305470 - Nucleic acid sequencing: e

20080305471 - Optoelectronic device and method of fabricating the same: A modified isolated polypeptide comprising an amino acid sequence encoding a photocatalytic unit of a photosynthetic organism being capable of covalent attachment to a solid surface and having a photocatalytic activity when attached thereto is disclosed.... Agent: Martin D. Moynihan Prtsi, Inc.

20080305487 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080305488 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080305478 - Processes using dual specificity oligonucleotide and dual specificity oligonucleotide: The present invention relates to various processes by a template-dependent extension reaction using a dual specificity oligonucleotide and a dual specificity oligonucleotide composed of three different Tm portions therefor. Demonstrated in the present invention are the features of the dual specificity oligonucleotide, which are high hybridization specificity and mismatch tolerance.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080305473 - Propagation of primary cells: The present invention provides a method of propagating cells of interest obtained from a biological specimen by enriching the cells under conditions that maintain sufficient cell viability; and propagating the cells under conditions effective to allow cell viability, proliferation and integrity.... Agent: Philip S. Johnson Johnson & Johnson

20080305486 - Signal amplification using circular hairpin probes: The present invention provides methods for detecting a target nucleic acid using a circular dual-hairpin probe that is formed upon the presence of the target nucleic acid. The detection methods find use in detecting the presence of antibody-antigen complexes and for detecting the binding of a ligand to its binding... Agent: Townsend And Townsend And Crew, LLP

20080305481 - Systems and methods for multiplex analysis of pcr in real time: The present invention provides methods and systems for real-time measurements of PCR with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the PCR process, and an imaging chamber of a measurement device that is also capable... Agent: Fulbright & Jaworski L.L.P.

20080305494 - Chemokine ccl18 as a biomarker: The invention relates to a diagnostic tool, e.g. to the chemokine CCL18 as a biomarker in a sample of a body fluid of an individual and its use in various methods.... Agent: Novartis Corporate Intellectual Property

20080305493 - Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods: Methods for identifying antineoplastic agents by using their ability to modify expression of specific genes or the biological activity of polypeptides encoded by such genes, wherein said genes are located in specific chromosomal regions, called amplicons, or regions of interest, and the presence of such amplified regions within a cancerous... Agent: Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein

20080305495 - Methods for determining the redox status of proteins: A method for determining the redox status of a protein sample, the method comprising the steps of: a) contacting the sample with a first label adapted to bind to at least one reduced cysteine group therein; b) contacting the sample with a reducing agent to reduce at least one oxidized... Agent: Edwards Angell Palmer & Dodge LLP

20080305499 - Anti-synoviolin antibody: The present invention relates to an antibody against synoviolin or a fragment thereof for providing a monoclonal antibody capable of recognizing a part of synoviolin, which monoclonal antibody is capable of inhibiting the auto-ubiquitination of synoviolin.... Agent: Dickstein Shapiro LLP

20080305498 - Biomarkers for use in vessel disorders: The present invention relate to a method of diagnosing a subject having a vessel disorder. More particularly, a biological sample is obtained from a subject suspected of having a vessel disorder. A protein profile is determined or measured in the sample using procedures described herein, for example, mass spectrometry or... Agent: Fulbright & Jaworski L.l.p

20080305501 - Compositions and methods for modulating rank activities: The present invention provides methods for identifying agents capable of modulating RANK-mediated invention also provides pharmaceutical compositions and methods of using the same for treating osteoporosis or other diseases. The present invention is based on the functional and structural analysis of a novel RANK signaling motif that was found to... Agent: Sutherland Asbill & Brennan LLP

20080305500 - Novel cell-based assays for identifying enhancers or inhibitors of t1r taste receptors (t1r2/t1r3 sweet) and umami (t1r1/t1r3 umami) taste receptors: This invention relates to improved assays for identifying modulators (enhancers or inhibitors) of sweet (T1R2/T1R3) and umami (T1R1/T1R3) taste receptors. These receptors may comprise the endogenous T1Rs e.g., from humans or rodents, or may comprise functional variants such as chimeric taste receptors comprising the extracellular portion of one T1R or... Agent: Hunton & Williams LLP Intellectual Property Department

20080305502 - Method of screening baff suppressor or inhibitor: A method of screening a novel BAFF suppressor or inhibitor. More specifically speaking, a method which comprises adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell to thereby induce the production of BAFF by the cell; a method of screening a substance capable... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20080305503 - Diagnostic test: The invention provides a method of diagnosing Mycobacterium tuberculosis infection in a human, or of determining whether a human has been exposed to Mycobacterium tuberculosis, comprising: (i) contacting T-cells from said human with one or more of (a) a peptide having the sequence shown in SEQ ID NO: 1; (b)... Agent: Fulbright & Jaworski, LLP

20080305504 - Compositions, methods, and kits for assaying complement activation: The present invention provides a fluorogenic composition for assaying complement activation that comprises a substrate for C3 convertase that is linked to a first fluorophore and a second fluorophore, wherein the fluorescence of the first and second fluorophores are mutually substantially quenched when the two fluorophores are present at a... Agent: General Electric Company Global Research

20080305496 - Method for identifying a compound that modulates sir2 protein activity: The present invention relates to a method for identifying compounds that modulate the activity of sirtuin deacetylase protein family members. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified nicotinamide inhibition and base... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20080305497 - Polymeric carriers for immunohistochemistry and in situ hybridization: Certain disclosed embodiments of the present invention concern the synthesis, derivatization, conjugation to immunoglobulins and signal amplification based on discrete, relatively short polymers having plural reactive functional groups that react with plural molecules of interest. Reactive functional groups, such as hydrazides, may be derivatized with a variety of detectable labels,... Agent: Klarquist Sparkman, LLP

20080305505 - Method for dissolution testing of pharmaceutical products: The present invention relates to the field of dissolution measurement and, more particularly to methods for reproducible dissolution testing of pharmaceutical products such as allergen vaccines.... Agent: Darby & Darby P.C.

20080305506 - Fluorescent dyes for use in glucose sensing: A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte detection.... Agent: Knobbe Martens Olson & Bear LLP

20080305507 - Methods and compositions for assaying homocysteine: This invention relates generally to the field of homocysteine detection. In particular, the invention provides a method for determining homocysteine presence or concentration in samples, which method comprises: contacting a sample containing or suspected of containing Hcy with a Hcy co-substrate and a Hcy converting enzyme in a Hcy conversion... Agent: Morrison & Foerster LLP

20080305509 - Fluorescence polarization assays for determining clostridial toxin activity: The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage... Agent: Allergan, Inc.

20080305510 - Fluorescence polarization assays for determining clostridial toxin activity: The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage... Agent: Allergan, Inc.

20080305508 - Methods of screening for compounds that modulate tafia activity, compounds, and methods of using the compounds: Provided are methods of screening compounds for any aspirin-related activity other than TAFI inhibition, and also for non-inhibition of TAFI. Compounds identified by the screening methods can be used to treat, prevent or manage in a patient pain, fever, colon cancer, pancreatic cancer or an inflammatory, platelet aggregation, fibrinolytic or... Agent: Frommer Lawrence & Haug

20080305511 - Method for screening antioxidant using mutant bacteria and chlorophyllide, and antioxidant screened by the method: The present invention enables easy screening of an antioxidant on an industrial scale, by monitoring growth profiles of mutant bacteria via the use of mutant bacteria and chlorophyllide. In particular, the antioxidant screening method in accordance with the present invention is very useful for selective screening of an amphiphilic antioxidant.... Agent: Christie, Parker & Hale, LLP

20080305512 - Assay for cardiac troponin autoantibodies: The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among... Agent: Paul D. Yasger Abbott Laboratories

20080305513 - Method of measuring cancer aggressiveness and detection thereof: Erythrocyte sedimentation rate (“ESR”) determinations of a patient's blood that has been combined either with blood serum from pregnant mammals or with fetal embryonic serum yield measurable results correlating well with the presence of an on-going cancer. This cancer detection method is based on differential ESR determinations and uses paired... Agent: Rosenberg, Klein & Lee

20080305514 - Method for detecting microbes: The present invention relates to methods for detecting microbes in a sample comprising filtering the sample through a fluid-permeable surface, contacting the surface with a viability stain, scanning the surface for viability stain to form a first scan, contacting the surface with a nucleic acid stain, scanning the surface for... Agent: Alcon

20080305515 - Pathology sample processing workstation: A pathology sample processing workstation. The samples are positioned on containers having RFID tags and processed at stations having RFID transceivers coupled to a computer. Information regarding the samples can stored on the RFID tags and retrieved using the transceivers.... Agent: Faegre & Benson Attn: Patent Docketing

20080305516 - Method of producing antibodies: Methods for producing immunoglobulin molecules or immunologically functional immunoglobulin fragments, the fragments comprising at least functional portions of the variable domains of immunoglobulin heavy and light chains, are described. The methods comprise producing the heavy and the light chains in two separate host cells and refolding the immunoglobulin molecule or... Agent: Novo Nordisk, Inc. Intellectual Property Department

20080305519 - Biochemical method for specific protein labeling: An improved method for protein labeling comprising the steps of providing a synthetic small molecule tag, providing a target protein to be tagged, providing at least two enzymes for catalyzing a conjugation reaction between the tag and the target protein, incubating the tag, the protein and the enzyme, and allowing... Agent: Phillips Lytle LLP Intellectual Property Group

20080305518 - O-linked glycoforms of polypeptides and method to manufacture them: The present invention relates to compositions comprising glycoproteins having altered patterns of O-linked glycosylation, in particular Factor VII, Factor IX, and methods for making these.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20080305517 - Transglutaminase crosslinked collagen biomaterial for medical implant materials: The present invention provides a method for producing an improved biomaterial comprising treating a collagen biomaterial with a transglutaminase under conditions which permit the formation of cross-links within the collagen. Preferably, the transglutaminase is a tissue transglutaminase, a plasma transglutaminase or a microbial transglutaminase. In a preferred embodiment, the collagen... Agent: Fish & Richardson PC

20080305523 - Fungal promoter for expressing a gene in a fungal cell: The present invention relates to isolated fungal promoter DNA sequences, to DNA constructs, vectors, and fungal host cells comprising these promoters in operative association with coding sequences encoding polypeptides. The present invention also relates to methods for expressing a gene and/or producing a polypeptide using the new promoters isolated. The... Agent: Nixon & Vanderhye, PC

20080305521 - Method for overproducing specific recombinant protein with p. cinnabarinus monokaryotic strains: The use of monokaryotic strains of filamentous fungi of the Pycnoporus species of the basidiomycete group, for implementing a method for preparing a specific recombinant protein, the method being carried out by overexpressing the gene encoding the protein in the Pycnoporus monokaryotic strain.... Agent: Young & Thompson

20080305524 - Molecular glue: The present invention relates to an adhesive material being composed and/or consisting of at least one protein obtained or obtainable from flagella from archaea. Furthermore, the present invention relates to the use of at least one protein obtained from flagella from archaea for the method for the preparation of an... Agent: Fulbright & Jaworski L.L.P.

20080305522 - Novel taste-modifying polypeptide nas, dna thereof and use thereof: (B) a polypeptide comprising an amino acid sequence with the substitution, deletion, insertion, addition or inversion of one or several amino acids in the amino acid sequence shown in SEQ ID NO.2 in the sequence listing, which polypeptide can form the neoculin dimer having a taste-modifying activity together with the... Agent: Antonelli, Terry, Stout & Kraus, LLP

20080305525 - Novel hansenula polymorpha gene coding for alpha 1,6-mannosyltransferase and process for the production of recombinant glycoproteins with hansenula polymorpha mutant strain deficient in the same gene: Disclosed are a novel Hansenula polymorpha gene coding for α-1,6-mannosyltransferase initiating outer chain elongation in N-linked glycosylation, an H. polymorpha mutant strain having a deficiency in the gene, and a process for producing recombinant glycoprotein using such a mutant strain.... Agent: Casimir Jones, S.c.

20080305526 - Melibiose operon expression system: New vectors expressible in a host comprising the promoter region of the melibiose operon operably linked to a transcriptional unit that includes nucleic acid sequence which is heterologous to the host. The expression of the nucleic acid sequence is controlled by the promoter region of the melibiose operon. The new... Agent: Fisher, Christen & Sabol

20080305527 - Single chain pan ecto-nox variable region (scfv) antibody, coding sequence and methods: The present Specification describes compositions and methods for production of a recombinant single chain variable region (ScFv) antibody useful for the detection of members of the ECTO-NOX family of cell surface proteins on Western blots. This single chain antibody is especially useful in the detection, diagnosis and monitoring of neoplastic... Agent: Greenlee Winner And Sullivan P C

20080305528 - Isolation of nucleic acids: A method for extracting nucleic acids from a biological material such as blood comprises contacting the mixture with a material at a pH such that the material is positively charged and will bind negatively charged nucleic acids and then eluting the nucleic acids at a pH when the said materials... Agent: Invitrogen Corporation C/o Intellevate

20080305529 - Glucose isomerase mutants, dna thereof and use thereof: This invention provides a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases with improved catalytic activity and thermostability obtained by using recombinant techniques. These recombinant glucose isomerases comprise amino acid variation including phenylalanine Phe) at position 139, alanine (Ala) at position 182, serine (Ser) at position 187, and glutamine (Gln) at... Agent: The Webb Law Firm, P.C.

20080305520 - Mechanosensitive ion channels and methods of use: The present invention provides methods for identifying agents that decrease the activity of a mechanosenitive ion channels, preferably, a mechanosensitive Ca2+-permeable channel (MscCa) channel. The present invention also provides methods for using agents that decrease the activity of mechanosenitive ion channels, including, for instance, methods for treating cancer, methods for... Agent: Mueting, Raasch & Gebhardt, P.A.

20080305530 - Method for producing (r)-and (s)-4-(1-ammoniumethyl)benzoic acid methylester-sulphate from racemic 4-(1-aminoethyl)benzoic acid methylester by lipase catalysed enantoselective acylation and subsequent precipitation with sulphuric acid: A method for preparing optically active methyl 4-(1-ammoniumethyl)benzoate sulfate by reacting racemic methyl 4-(1-aminoethyl)benzoate with an acylating agent in the presence of a lipase to give methyl 4-(1-aminoethyl)benzoate and subsequently precipitating methyl 4-(1-ammoniumethyl)benzoate sulfate by adding sulfuric acid.... Agent: Connolly Bove Lodge & Hutz, LLP

20080305531 - Compositions and methods for making and modifying oils: The invention provides novel methods for making or modifying oils, e.g., plant, animal or microbial oils, such as vegetable oils or related compounds, that are low in a particular fatty acid(s), for example, low linoleic oils, low linolenic oils, low palmitic oils, low stearic oils or oils low in a... Agent: Verenium C/o Mofo S.d.

20080305532 - Gene for coenzyme pqq synthesis protein b from gluconobacter oxydans: The present invention relates to a newly identified gene that encodes a protein that is involved in the synthesis of L-ascorbic acid (hereinafter also referred to a Vitamin C). The protein is coenzyme PQQ synthesis protein B. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel... Agent: Nixon & Vanderhye, PC

20080305533 - Recombinant microorganisms for increased production of organic acids: Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf) gene. The recombinant... Agent: Womble Carlyle Sandridge & Rice, PLLC

20080305534 - Novel glycerol dehydrogenase, gene therefor, and method of utilizing the same: Furthermore, the present invention provides a polypeptide comprising the amino acid sequence represented by SEQ ID NO: 1 in the Sequence Listing, a DNA encoding the polypeptide, and a transformant producing the polypeptide in large quantities. Still furthermore, the present invention provides a manufacturing method by using the above polypeptide... Agent: Sughrue Mion, PLLC

20080305535 - In vitro amplification of nucleic acid molecules via circular replicons: Methods and compositions suitable for accomplishing the in vitro amplification of nucleic acid molecules via enzymatic means are provided. The preferred means employ circular rather than linear replicons. Means for producing such circular replicons from linear reactants are also provided.... Agent: K&l Gates LLP

20080305536 - Method for culturing microorganisms: The present invention is a method for the production of thermophilic microorganisms suitable for the production of ethanol, comprising: (i) culturing a thermophilic microorganism under aerobic or anaerobic conditions in a suitable culture media; and (ii) incorporating amounts of ethanol into the culture media to induce ethanol tolerance.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080305537 - Microchips and its manufacturing methods thereof: A microchip is provided with a lower substrate configured as the lower portion of the microchip, an intermediate section formed on the top of the lower substrate, and an upper substrate formed on the top of the intermediate section, wherein the lower substrate, the intermediate section, and the upper substrate... Agent: Law Offices Of Albert Wai-kit Chan, PLLC

20080305538 - Rapid and sensitive detection of bacteria in blood products, urine, and other fluids: The invention provides methods of detecting bacteria in fluids, including blood, platelets and other blood products for transfusion, and urine. The methods are based on lysing the bacteria to release ATP and detecting the ATP. Eukaryotic cell contamination is a problem to be overcome, because eukaryotic cell contain large amounts... Agent: Hugh Mctavish Mctavish Patent Firm

20080305539 - Membrane supported bioreactor for conversion of syngas components to liquid products: Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO2 and H2 with a surface of a membrane and transferring these components in contact with a biofilm on the opposite side of the membrane. These steps provide a stable system for... Agent: Cardinal Law Group

20080305540 - Membrane supported bioreactor for conversion of syngas components to liquid products: Ethanol and other liquid products are produced by contacting syngas components such as CO or a mixture of CO2 and H2 with a surface of a membrane under anaerobic conditions and transferring these components in contact with a biofilm on the opposite side of the membrane. These steps provide a... Agent: Cardinal Law Group

20080305541 - Recombinant vectors for use in position-independent transgene expression within chromatin: The embodiments of the present invention are directed to discrete, cis-acting regulatory elements that include a barrier element, an insulating element, a silencing element, and matrix attachment regions (“MARs”). Additional embodiments of the present invention are directed to nucleic acid molecules that are useful for facilitating stable transgene expression within... Agent: Olympic Patent Works PLLC

20080305542 - Human t2r61 taste receptor for identifying human bitter taste modulators: The claimed invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R61 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor.... Agent: Hunton & Williams LLP Intellectual Property Department

20080305543 - Rna interference pathway genes as tools for targeted genetic interference: Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080305546 - Method for cultivating tendon cells from pluripotent cells of mesenchymal origin: A method for cultivating tendon cells from non-embryonic pluripotent cells of mesenchymal origin is described, wherein the isolated cells are cultivated in a culture medium under standard culture conditions in a culture vessel. In order to increase the collagen secretion, it is proposed that before their complete confluence, the cells... Agent: Collard & Roe, P.C.

20080305544 - Method of producing nerve cell: An Object of the present invention is to provide a process for producing a nerve cell by inducing differentiation of an embryonic stem cell, a method for inducing differentiation of the embryonic stem cell into a nerve cell, a medium to be used in the production process or differentiation induction... Agent: Fitzpatrick Cella Harper & Scinto

20080305545 - Shape memory thermoplastics and polymer networks for tissue engineering: Methods and compositions are described herein for reconstruction of different functional tissues. Dissociated cells, differentiated cells, adult mesenchymal stem cells or embryonic stem cells are seeded on a scaffold. The scaffold will consist of a biocompatible, biodegradable shape memory (“SM”) polymers. In addition bioactive substances may be incorporated in the... Agent: Hogan & Hartson LLPIPGroup, Columbia Square

20080305547 - Method for enhanced functional expression of cell receptors: The invention relates to methods for enhancing functional expression of receptor molecules in recombinant cells, preferably heterologous cells. In the method, a eukaryotic cell is transformed or transfected with all of the nucleic acid molecule which encodes the receptor, one which encodes a GEF, such as Ric-8A or Ric-8B, and... Agent: Fulbright & Jaworski, LLP

20080299536 - Material and methods for nerve grafting: The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue using nerve grafts and preparation of nerve grafts. The compositions and methods of the subject invention can be employed to restore the continuity of nerve interrupted by disease, traumatic events or surgical procedures. Compositions of... Agent: Goodwin Procter LLP Patent Administrator

20080299535 - Preservative solution for cells, tissues and organs comprising rare sugar and preservation method with the use of the same: [Means for Resolution] A preservative solution for cryopreservation of animal or human organs and animal or plant tissues or cells, the solution containing a rare sugar D-allose. A preservative solution for cryopreservation of the human kidney, cells derived from animals or humans, or human or animal sperm and/or ovum and/or... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20080299537 - Apparatus and methods for selecting capacitated spermatozoa and uses thereof: The present invention relates to apparatus, systems and methods for generating a subpopulation of spermatozoa enriched for capacitated spermatozoa, by exposure of a population of spermatozoa to a suitable temperature gradient, and retrieving the enriched subpopulation of spermatozoa for further applications, such as, for diagnosis or fertility treatments.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080299538 - Pathogen inactivation of whole blood: This invention is directed toward a method of pathogen inactivating whole blood. The steps include collecting whole blood from a donor into a bag; illuminating the whole blood with light at a sufficient energy so that an alloxazine photosensitizer present in the whole blood may be photolyzed to inactivate any... Agent: Caridianbct, Inc. Mail Stop: 810 1f2

20080299539 - Parallel integrated bioreactor device and method: In one embodiment, the present invention introduces integrated fluid injection and mixing devices to enable pH control in a miniature parallel integrated bioreactor array system. In another embodiment, the environmental conditions of the growth chamber is enabled through fluidic injections in a miniature parallel cell culture system. In still another... Agent: Choate, Hall & Stewart LLP

20080299540 - Hormone responsive tissue culture system and uses thereof: The invention also provides methods to transform normal primary cells so cultured into “cancer stem cells.” The genetically defined cancer stem cell tumor model mimics the behavior of the disease closely, e.g., the cells are invasive, hormone responsive and metastatic when injected into mice. The tumor cells express genes that... Agent: Ropes & Gray LLP

20080299542 - Identification of oxidatively modified peptide sequences in the proteome (loscalzo): The invention relates, in part, to identifying protein target(s) that undergo oxidative modification and the specific peptide sequences bearing oxidation-induced modifications.... Agent: Wolf Greenfield & Sacks, P.C.

20080299541 - Method and apparatus for measuring enzymatic activity by use of laser: A method of measuring an enzymatic activity, includes measuring the quantity of a substrate metabolite produced upon metabolism of a substrate by an enzyme, through detecting a radiant wave generated from a multiple photon excitation process of the substrate or the substrate metabolite.... Agent: Bell, Boyd & Lloyd, LLP

20080299543 - Method for assessing trace element related disorders in blood plasma: The present invention provides for spectrometric methods of analyzing plasma or serum for metal distribution in metalloproteins. The methods can be used to assess such conditions as toxicity and disease in subjects.... Agent: Fulbright & Jaworski L.L.P.

20080299545 - Chromatographic methods for assessing adenovirus purity: Methods for determining the quantity, quality and purity of a previously purified virus sample are disclosed. Such methods, which include the use of high performance size exclusion chromatography to determine these attributes are also disclosed.... Agent: Fulbright & Jaworski L.L.P.

20080299544 - Hcv multiple epitope fusion antigens with modified proteolytic cleavage sites and uses thereof: Modified HCV multiple epitope fusion antigens (MEFAs) are described. The proteins include modified sequences such that proteolytic cleavage of the MEFAs by HCV NS3 protease is inhibited. HCV immunoassays including the modified MEFAs are also described.... Agent: Novartis Vaccines And Diagnostics Inc.

20080299546 - Canine cd20 gene: It is intended to clarify the CD20 amino acid sequence and its gene sequence which are essentially required in constructing an anti-CD20 antibody useful in treating animal malignant lymphoma. It is also intended to provide a method of diagnosing canine malignant lymphoma by using the gene sequence. Using monocytes in... Agent: Young & Thompson

20080299564 - Control of preservation by biomarkers: The invention lies in the field of microbiology, more particularly in the field of (food) preservation and testing of viability of microbiological spores. It is shown that measurement of the integrity of both rRNA and mRNA in spores is an accurate indicator of viability. Nucleotide assays then form a significant... Agent: Lucas & Mercanti, LLP

20080299582 - Culture system for rapid expansion of human embryonic stem cells: This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described here, the role of feeder cells is replaced by components added to... Agent: Geron Corporation Attn. David J. Earp

20080299548 - Gene expressed specifically in es cells and utilization of the same: The present invention relates to an ES cell detection marker containing a polynucleotide derived from any one of ECAT15-1 gene, ECAT15-2 gene, ECAT16 gene, Rnf17 gene and LOC380905(TDRD4) gene.... Agent: Leydig Voit & Mayer, Ltd

20080299554 - Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with liver fibrosis and related pathologies. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, including groups of nucleic acid molecules that may be used as a signature marker set, variant proteins... Agent: Celera Corporation

20080299563 - Human map2 gene promoter: The human MAP2 gene promoter as well as various fragments thereof are disclosed. Nucleic acids and host cells that contain the promoter sequences are also disclosed. Further disclosed are various methods involving the use of these sequences.... Agent: Quarles & Brady LLP

20080299568 - Materials and methods for detection of hepatitis c virus: Disclosed are methods and compositions for detecting hepatitis C virus (HCV) in a sample. Typically, the methods include amplifying nucleic acids and detecting signals, such as signals emitted from fluorophores. The signals may be correlated to the presence and/or quantity of the hepatitis C viral genome in the sample. In... Agent: Foley & Lardner LLP

20080299583 - Method and system for analyzing reactions using an information system: A method and system for determining the quantity of an analyte initially present in a chemical and or biological reaction as well as a computer implemented method and system to automate portions of the analysis comprising mathematical or graphical analysis of an amplification reaction.... Agent: Paul D. Yasger Abbott Laboratories

20080299558 - Method for detecting nucleic acid: The present invention provides a method for detecting a nucleic acid by specific binding between ligand and receptor, in particular, a method of detecting a SNP by the specific binding between a ligand and receptor. The present invention also provides a method for detecting a nucleic acid that is simpler,... Agent: Scully Scott Murphy & Presser, PC

20080299552 - Method for determining the function of nucleic acid sequences and expression products coded thereby: The invention relates to a method for the investigation and determination of the function of nucleic acid sequences and nucleic acid expression products by the introduction of RNA into host cells.... Agent: Olson & Cepuritis, Ltd.

20080299549 - Methods and compositions for the detection of a nucleic acid by a cleavage reaction: The invention provides methods, compositions and kits for generating a signal indicative of the presence of a target nucleic acid sequence in a sample comprising forming a cleavage structure by incubating a sample comprising a target nucleic acid sequence with upstream and downstream oligonucleotides, and cleaving the cleavage structure with... Agent: Agilent Techologies Inc

20080299550 - Methods and kits for the prediction of therapeutic success and recurrence free survival in cancer therapy: The invention provides novel compositions, methods and uses, for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia and breast cancer. The invention further relates to genes that are differentially expressed in breast tissue of breast cancer patients versus those of normal “healthy” tissue. Differentially expressed genes for the... Agent: Barbara A. Shimei Director, Patents & Licensing

20080299559 - Methods for authenticating articles with optical reporters: This invention pertains to methods for authenticating an article comprising tagging the article with light emitting optical reporter particles, and more specifically tagging the articles with up-converting phosphor particles (UCP), linked to nucleic acids of detectable sequence.... Agent: Virtual Legal, P.C. Michael A. Kerr

20080299551 - Methylation of estrogen receptor alpha and uses thereof: Methods for diagnosis, prognosis, and treatment of cancer based on the methylation status of the ER-α gene promoter are disclosed. Methylation of the ER-α gene promoter is indicative of cancer and unfavorable prognosis. The cancer can be treated with a demethylation agent.... Agent: Hogan & Hartson L.L.P.

20080299566 - Methylation of gene promoters as a predictor of effectiveness of therapy: The present invention provides methods for identifying, diagnosing, evaluating or monitoring a disease state in a subject comprising identifying the methylation status of a panel of genes in the subject. The present invention also relates to identifying, diagnosing, evaluating or monitoring the responsiveness of a subject to a therapeutic regimen,... Agent: Sughrue Mion, PLLC

20080299555 - Multicolor chromogenic detection of biomarkers: The present invention provides compositions, kits, assembles of articles and methodology for detecting multiple target molecules in a sample, such as in a tissue sample. In particular, site-specific deposition of elemental metal is used in conjunction with other means of detection, such as other chromogenic, radioactive, chemiluminescent and fluorescent labeling,... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20080299579 - Novel cancer marker and use thereof: This invention provides a method for cancer diagnosis comprising measuring an endogenous antisense RNA whose relative expression to a sense RNA changes cancer-specifically in RNA-containing samples collected from a mammal. Also provided are endogenous antisense RNAs useful as cancer markers, and cancer diagnostic reagents containing the same.... Agent: Leydig Voit & Mayer, Ltd

20080299547 - Novel stra6 polypeptides: The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention... Agent: Merchant & Gould PC

20080299561 - Novel therapeutic targets in cancer: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20080299562 - Nucleic acid-based tests for rhd typing, gender determination and nucleic acid quantification: The invention in part provides nucleic acid-based assays, which are particularly useful for non-invasive prenatal testing. The invention in part provides compositions and methods for RhD typing, detecting the presence of fetal nucleic in a sample, determining the relative amount of fetal nucleic acid in a sample and determining the... Agent: Grant Anderson LLP C/o Portfolioip

20080299560 - Nucleophosmin protein (npm) mutants, corresponding gene sequences and uses thereof: The invention relates to new nucleophosmin protein (NPM) mutants, corresponding gene sequences and relative uses thereof for diagnosis, monitoring of minimal residual disease; prognostic evaluation and therapy of the acute myeloid leukaemia (AML)... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo Attn: Patent Intake Customer No. 35437

20080299553 - Oligonucleotide probes for the genomic typifying of erythrocyte systems, methods and relative diagnostic kits: The invention relates to oligonucleotide probes for the genomic typifying of erythrocyte systems, relative methods and diagnostic kits.... Agent: Hedman & Costigan P.C.

20080299567 - Primer and probe sequences for detecting chlamydia trachomatis: The present invention relates to primers and probes that can be used in various assays to detect a new strain of Chlamydia trachomatis. The invention further provides for the simultaneous detection of other diseases, especially Neisseria gonorrhoeae.... Agent: Paul D. Yasger Abbott Laboratories

20080299565 - Probe for nucleic acid sequencing and methods of use: A nanoprobe for sequencing of nucleic acid molecules is provided, as well as methods for using the nanoprobe. In particular examples, the probe includes a polymerizing agent and one or more molecular linkers that carry a chemical moiety capable of reversibly binding to the template strand of a nucleic acid... Agent: Klarquist Sparkman, LLP

20080299569 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080299570 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080299571 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080299572 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080299573 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080299574 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080299575 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080299576 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080299577 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080299578 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080299557 - Sample lysis and coating of reaction surface: The present invention provides copolymers that facilitate nucleic acid analysis, compositions that comprise such copolymers, and methods for making or using such copolymers.... Agent: Seed Intellectual Property Law Group PLLC

20080299581 - Screening for expressible transfectants in a eukaryotic system: The present invention relates to the field of molecular cloning and to the field of expression cloning in higher, eukaryotic cells. In particular, the present invention relates to a method for fast and reliable identification of vectors and vector DNA which will be capable of providing a desired expression product... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080299580 - Targeted integration into the ppp1r12c locus: Disclosed herein are methods and compositions for targeted integration of an exogenous sequence into the human PPP1R12C locus, for example, for expression of a polypeptide of interest.... Agent: Robins & Pasternak

20080299588 - Methods for measuring bone formation: The present invention relates to methods for detecting and monitoring bone mineralization. The invention provides antibodies, kits, and methods of use for detecting or monitoring the rate of bone mineralization associated with bone disorders such as osteoporosis.... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080299587 - Methods of measuring inhibition of platelet aggregation by thrombin receptor antagonists: A method is provided for measuring inhibition of platelet aggregation by a thrombin receptor antagonist. First, a blood sample is obtained from a patient treated with a thrombin receptor antagonist. The blood sample is mixed in combination with particles including an immobilized GPIIb/IIIa receptor ligand and a thrombin receptor activator.... Agent: Morrison & Foerster LLP

20080299586 - Olfactory receptors for isolvaleric acid and related malodorants and use thereof in assays for identification of blockers: A subgenus of olfactory receptors (ORs) that are activated by isovaleric acid (IVA) are identified as well as assays that utilize one or more of these ORs. These assays are useful for identifying potential anti-odorants which may be used in deodorants, air and carpet fresheners, fabric deodorizers, and other compositions... Agent: Hunton & Williams LLP Intellectual Property Department

20080299589 - Methods and materials for examining the p13k/akt pathway in gliomas and prostate cancers: The invention disclosed herein provides methods for the examination and/or quantification of the PI3K/Akt and Ras/MAPK biochemical pathways that are disregulated in pathologies such as cancers of the prostate and gliomas. The invention disclosed herein further provides reagents and kits adapted for performing such methods.... Agent: Gates & Cooper LLP Howard Hughes Center

20080299590 - Shc protein-related methods and compositions: The present invention provides a method for predicting whether an individual (e.g., patient) will benefit from a (one or more) treatment for cancer comprising determining the amount of p66-Shc present in cancerous cells or precancerous cells (e.g., displasia) of the individual. If the amount of p66-Shc present in the cells... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080299591 - Identification of porphyromonas gingivalis virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases: The invention provides compositions and methods for the detection of Porphyromonas gingivalis and for the treatment and prevention of diseases and infections caused by P. gingivalis.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080299585 - Methods for detection and measurement of secretory phospholipase a2 levels (spla2) in biological fluids: Elevated levels of secretory phospholipase A2 (sPLA2) are associated with a variety of inflammatory conditions, e.g., multiple sclerosis, arteriosclerosis, rheumatoid arthritis, osteoarthritis and sickle cell. ELISA-based assays have been developed for detecting and measuring sPLA2 levels in biological fluids, but these methods are too time-consuming for practical clinical diagnostic use.... Agent: Perkins Coie LLP

20080299584 - Oncoprotein protein kinase antibody kit: An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP

20080299593 - Luminogenic and fluorogenic compounds and methods to detect molecules or conditions: A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.... Agent: Schwegman, Lundberg & Woessner, P.A.

20080299592 - Red-shifted luciferase: The compositions described herein shift the light output of luciferases to the near-IR by resonance energy transfer to a targetable near-IR fluorophore.... Agent: Fish & Richardson PC

20080299594 - Proteomic analysis of biological fluids: The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns the identification of the proteome of amniotic fluid... Agent: Goodwin Procter LLP Attn: Patent Administrator

20080299595 - Tailored glycoproteomic methods for the sequencing, mapping and identification of cellular glycoproteins: The present disclosure relates to tailored glycoproteomic methods, and more particularly to methods for the sequencing, mapping and identification of cellular glycoproteins using saccharide-selective bioorthogonal probes. A method is disclosed for saccharide-selective glycoprotein identification (ID) and glycan mapping (GIDmap) that generates glycoproteins tailored with bioorthogonally tagged alkynyl saccharides that can... Agent: Greenberg Traurig LLP (la)

20080299597 - Methods for assaying percentage of glycated hemoglobin: The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular... Agent: Morrison & Foerster LLP

20080299596 - Substrates and assays for beta-secretase activity: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.... Agent: Marshall, Gerstein & Borun LLP

20080299601 - Adhering surfaces: The present invention relates, in part, to compositions useful for cell culture having one surface in adherence to another surface, e.g., a cell culture matrix in adherence to a surface. The present invention also relates, in part, to methods of adhering one surface to another surface, e.g., adhering a cell... Agent: Invitrogen Corporation C/o Intellevate

20080299600 - Apparatus assembly and method for detecting an analyte: An apparatus assembly for detecting an analyte in a sample of material includes a generally self-contained housing and an indicator cap. The housing is moveable between a sample preparation orientation and a testing orientation and is configured to interchangeably receive a sample collection device and the indicator cap having a... Agent: 3m Innovative Properties Company

20080299598 - Detector comprising a membrane perturbation - detecting polymer and functional membrane fragments: A construct comprising functional membrane fragments and one or more perturbation-detecting polymers associated therewith, wherein said construct responds to perturbations of said membrane fragments by means of a detectable change in one or more physical or chemical properties associated with said construct.... Agent: Nixon & Vanderhye, PC

20080299599 - Fluorescent proteins for monitoring intracellular superoxide production: Protein probes and methods for measuring real-time changes in intracellular superoxide formation are provided. The probes include superoxide sensitive variants of yellow fluorescent and green fluorescent proteins. The probes, or nucleic acids encoding the probes, may be delivered to cells or organisms. Changes in the fluorescence of the probes may... Agent: Blank Rome LLP

20080299602 - Methods of employing vascular leakage to diagnose a capillary leak disorder: A method of diagnosing a capillary leak disorder in a patient includes monitoring the marinobufagenin level in blood and/or urine as indicators of vascular permeability and, if a substantial elevation in marinobufagenin exists with respect to that of a normal person, concluding that a capillary leak disorder exists. The method... Agent: Arnold B. Silverman Eckert Seamans Cherin & Mellott, LLC

20080299603 - Predictive assay for immune response: The present invention relates to an in vitro method for determining the ability of a vaccine composition which comprises one or more antigens or a nucleic acid molecule which encodes one or more antigens to stimulate a T cell response. In one embodiment, the method comprises the steps of: (1)... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080299604 - Methods and tools for detecting collagen degradation: Fluorophore-labeled collagen covalently bound to a cell culture vessel can be used to assay collagen degradation by a variety of cell types, including osteoclasts and tumor cells. Such assays provide a high throughput platform for rapid screening of large numbers of potential modulators of, for example, tumor metastasis or osteoclast... Agent: Banner & Witcoff, Ltd.

20080299605 - Useful specimen transport apparatus with integral capability to allow three dimensional x-ray images: The present invention provides new and useful features and mechanisms for the localization and transport of biopsy specimens. The invention having a specimen board, an absorbent material in operative engagement and in coplanar alignment with the specimen board, a compression sheet, radio opaque indicia located within the specimen board, and... Agent: Mchale & Slavin, P.A.

20080299606 - Fermentative production of organic compounds: b) addition of the liquid (1) which comprises mono- or oligosaccharides together with metabolizable mono-, di- or oligosaccharides or together with a composition which comprises metabolizable mono-, di- or oligosaccharide in a concentration of at least 50% by weight and which is essentially free from solids which are insoluble in... Agent: Connolly Bove Lodge & Hutz, LLP

20080299607 - Enzymatic process to produce highly functional soy protein from crude soy material: This invention relates generally to the processing of soy-derived materials for use in various products. More particularly, the invention relates to a process producing highly functional soy protein using ultrafiltration followed by an enzymatic treatment.... Agent: Fitch Even Tabin & Flannery

20080299615 - Beta1,3-n-acetyl-d-galactosamine transferase protein, nucleic acid encoding the same and method of examining canceration using the same: The N-acetyl-D-galactosamine transferase protein of the present invention is characterized by transferring N-acetyl-D-galactosamine to N-acetyl-D-glucosamine with β1,3 linkage, and it preferably has the amino acid sequence shown in SEQ ID NO: 2 or 4. The canceration assay according to the present invention uses a nucleic acid for measurement which hybridizes... Agent: Nixon & Vanderhye, PC

20080299613 - Compositions for degrading cellulosic material: The present invention relates to cellulolytic compositions for degrading or converting cellulose-containing material and methods of producing and using the compositions.... Agent: Novozymes, Inc.

20080299612 - Fusion proteins with cleavable spacers and uses thereof: A polypeptide comprising a first protein domain, a second protein domain, and a dithiocyclopeptide spacer containing at least one protease cleavage site, wherein the dithiocyclopeptide is exogenous relative to the first or second protein domain, and wherein the first and second protein domains are operably linked by the dithiocyclopeptide. Also... Agent: Hogan & Hartson L.L.P.

20080299611 - Host cell protein knock-out cells for production of therapeutic proteins: The present invention relates to methods and means for making Vitamin K-dependent protein compositions which are devoid or substantially devoid of protein contaminants. In particular, methods and means useful for the reduction or elimination of protein contaminants also being Vitamin K-dependent proteins are described.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20080299610 - Human toll homologue: The invention relates to the identification and isolation of novel DNAs encoding the human Toll protein PRO358 and its variants, and to methods and means for the recombinant production of these proteins. The invention also concerns antibodies specifically binding the PRO358.... Agent: Gates & Cooper LLP Howard Hughes Center

20080299614 - Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters: The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the... Agent: Danisco US Inc., Genencor Division

20080299608 - Method for the in vivo modification of the synthesis activity of a metabolite by means of the modification of a gene the activity of which is not the original activity: The invention relates to a method for altering a protein X such as to modify the characteristics thereof by a) obtaining the mutants X* of the sequence coding for protein X, by means of aleatory mutagenesis, b) transformation of cells with a phenotype [P-] with vectors comprising the mutated nucleic... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080299609 - Uracil-dna glycosylase of psychrobacter sp. hj147 and use thereof: The present invention provides uracil-DNA glycosylase (UDG) gene originating from Psychrobacter sp. HJ147, and amino acid sequences deduced from the gene; expression and purification of Psp HJ147 UDG gene in Escherichia coli; and characterization of UDG obtained therefrom, and the use thereof in a polymerase chain reaction (PCR). The UDG... Agent: Edwards Angell Palmer & Dodge LLP

20080299616 - Malate synthase regulatory sequences for heterologous gene expression in pichia: The present invention relates to the isolation of DNA regulatory regions of the malate synthase 1 gene (MLS1) from the yeast, Pichia pastoris. The present invention further relates to the expression of heterologous proteins which have been introduced into a P. pastoris host cell and can be expressed under the... Agent: Merck And Co., Inc

20080299617 - Methods and host cells for recombinant protein expression: Methods for expressing recombinant polypeptides in host cells and host cells for polypeptide expression are provided.... Agent: Woodcock Washburn LLP

20080299618 - Single domain ligands, receptors comprising said ligands, methods for their production and use of said ligands and receptors: The present invention relates to single domain ligands derived from molecules in the immunoglobulin (Ig) superfamily, receptors comprising at least one such ligand, methods for cloning, amplifying and expressing DNA sequences encoding such ligands, preferably using the polymerase chain reaction, methods for the use of said DNA sequences in the... Agent: Nixon & Vanderhye, PC

20080299619 - Trichoderma reesei glucoamylase and homologs thereof: The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for the glucoamylases, vectors and host cells incorporating the DNA sequences,... Agent: Genencor International, Inc. Attention: Legal Department

20080299620 - Escherichia strain capable of converting xmp to gmp and maintaining the inactivated state of gene(s) associated with gmp degradation and methods of using the same: Provided are mutant strains derived from Escherichia sp. GPU1114 (Accession No. KCCM-10536), having cumulative inactivation of deoD, aphA, appA, and hprt genes, and methods of using the same.... Agent: Occhiuti Rohlicek & Tsao, LLP

20080299621 - Miniprep system for simple and rapid plasmid dna extraction: The invention relates to a modified microspin system for the isolation and purification of plasmid DNA. A disposable pre-filter column is used in combination with the traditional microspin column for increase speed and quality of plasmid DNA preparation. The disposable pre-filter column includes a pre-filter and a depth filter for... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20080299622 - Starch hydrolysis using phytase with an alpha amylase: The present invention relates to a method for liquefying starch comprising contacting a slurry of a starch substrate with an enzyme composition comprising a phytase and an alpha amylase. The invention also relates to an enzyme mixture comprising a phytase derived from Buttiauxella sp. and variants thereof and an alpha... Agent: Jennifer A. Haynes Danisco Us, Inc., Genencor Division

20080299556 - Alkylguanyltransferase assays: This invention provides a method to determine alkylguanyltransferase activity in a sample, comprising steps of placing the sample in an appropriate condition so that the AGT is functional; contacting the sample with an AGT Detector under conditions permitting the binding of AGT and AGTD to produce a signal; and measuring... Agent: Law Offices Of Albert Wai-kit Chan, PLLC

20080299623 - Enzyme catalysis in the presence of ionic liquids: The invention relates to the implementation of enzyme-catalysed reactions in the presence of ionic liquids.... Agent: Dann, Dorfman, Herrell & Skillman

20080299624 - Continuous fermentation apparatus and method: The present invention includes a method for the continuous fermentation of a desired product by the establishment of a steady state condition in a reactor followed by the nonsequential discharge of nutrient media through a plurality of intake ports. The nonsequential discharge of a plug of nutrient media causes a... Agent: Simpson & Simpson, PLLC

20080299625 - Microbial strains producing sphingoid bases or derivatives thereof: The present invention provides microbial strains, in particular yeast strains, that produce at least 0.1 mg per g biomass dry weight of a sphingoid base. The present invention further provides a method to obtain sphingoid base-producing microbial strains comprising incubating a population of microbial cells in the presence of a... Agent: Oliff & Berridge, PLC

20080299626 - Process for the production of an optically enriched tertiary alcohol: A process for the production of an optically enriched tertiary alcohol of the formula (2a) or (2b), by reacting an epoxide of the formula (1) with a nucleophilic agent Nu in the presence of halohydrin dehalogenase.... Agent: Connolly Bove Lodge & Hutz, LLP

20080299627 - Method for production of high purity polyhydroxyalkanonate (phas): The present invention relates to a method of producing polyhydroxyalkanoates (PHAs) using Bacillus sp. with succinate as a carbon source. The PHAs comprise more than 95% of poly(3-hydroxyvalerate-co-4-hydroxyvalerate) (P3HV-co-P4HV).... Agent: Wpat, PC Intellectual Property Attorneys

20080299628 - Continuous counter-current organosolv processing of lignocellulosic feedstocks: A modular process for organosolv fractionation of lignocellulosic feedstocks into component parts and further processing of said component parts into at least fuel-grade ethanol and four classes of lignin derivatives. The modular process comprises a first processing module configured for physico-chemically digesting lignocellulosic feedstocks with an organic solvent thereby producing... Agent: Fasken Martineau Dumoulin, LLP

20080299629 - Continuous counter-current organosolv processing of lignocellulosic feedstocks: A modular process for organosolv fractionation of lignocellulosic feedstocks into component parts and further processing of said component parts into at least fuel-grade ethanol and four classes of lignin derivatives. The modular process comprises a first processing module configured for physico-chemically digesting lignocellulosic feedstocks with an organic solvent thereby producing... Agent: Fasken Martineau Dumoulin, LLP

20080299630 - Ethanol fermentation process and products: The present invention provides a novel process for ethanol fermentation which uses a high concentration of fresh yeast to co produce ethanol and good quality yeast.... Agent: The Webb Law Firm, P.C.

20080299631 - Ethanol production from graminaceous plants by using immobilized carbohydrate hydrolases on nanoparticles: The present invention relates to a carbohydrate hydrolase-immobilized magnetic nanoparticle; a method of preparing ethanol from graminaceous plants and a continuous system of preparing ethanol.... Agent: Wpat, PC Intellectual Property Attorneys

20080299632 - Methods for recovering oil from a fractionated dry milling process: Processes for recovering oil from thin stillage produced during a fractionation-based dry milling process. The thin stillage can be heated or heated in combination with centrifuging to separate and recover oil from the thin stillage. Optionally, the thin stillage may be concentrated prior to recovering the oil.... Agent: Cantor Colburn, LLP

20080299633 - Systems and processes for cellulosic ethanol production: A cellulosic ethanol production process. An implementation of a process for producing fuel ethanol and biodiesel from cellulose may include: providing a raw cellulose stream by mixing a waste cellulose stream and an algae cellulose stream, hydrolyzing the raw cellulose stream to form a hydrolyzed cellulose stream, liquefying the hydrolyzed... Agent: Booth Udall, PLC

20080299634 - Biogas installation for production of biogas from biomass, and methods for operation of the biogas installation: A biogas installation for production of biogas from biomass and methods for starting and shutting down a fermenter are disclosed. When biomass in a fermenter is used up, biogas production must stop, the fermented biomass removed, and the fermenter filled with fresh biomass. Biogas production and utilisation is maintained for... Agent: Morrison & Foerster, LLP

20080299635 - Biogenic fuel gas generation in geologic hydrocarbon deposits: A method for stimulating methane production from a carbonaceous material is described. The methods may include the step of contacting the material with cells of a methanogenic consortium under anaerobic conditions to form a reaction mixture. The method may also include maintaining anaerobic conditions for a time sufficient to permit... Agent: Townsend And Townsend And Crew, LLP

20080299636 - System and method for inactivating microorganisms with a femtosecond laser: The invention relates to a method of inactivating or diminishing the activity of microorganisms and an apparatus implementing that method. Microorganism activity is diminished through exciting the vibrational state of a microorganism with pulses of radiation femtoseconds in width. The wavelength of the pulses is in a range of the... Agent: Schmeiser Olsen & Watts

20080299637 - Production of conjugates: A method of reacting a first chemical entity and a second chemical entity to form a conjugate in which the first and second chemical entities are covalently bound with respect to each other, comprises bringing into simultaneous contact the first chemical entity, the second chemical entity and a thiol generator,... Agent: Morgan Lewis & Bockius LLP

20080299638 - Pharmaceutical composition and method of treating hepatitis with arginases: The invention discloses methods for treating hepatitis with human arginase I modified by polyethylene glycol and uses of it in manufacturing of a medicament.... Agent: EagleIPLimited

20080299639 - Anti-inflammatory medicaments: Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.... Agent: Hovey Williams LLP

20080299640 - Acid alpha-glucosidase and fragments thereof: Targeted acid alpha-glucosidase therapeutics that localize to the lysosome are provided. The targeted therapeutics include a therapeutic agent, GAA, and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular localization of the targeted therapeutic upon internalization of the receptor. Nucleic acids, cells,... Agent: Choate, Hall & Stewart LLP

20080299641 - Novel e. coli 0157:h7 bacteriophage and uses thereof: The present invention is directed to isolated bacteriophage having strong lytic activity against strains of E. coli O157:H7, and methods of using that bacteriophage, and/or progeny or derivatives derived therefrom, to control the growth of E. coli O157:H7 in various settings.... Agent: Hunton & Williams LLP Intellectual Property Department

20080299642 - Vectors with modified protease-dependent tropism: The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modified to be cleaved by different proteases, were produced. In cells transfected with these... Agent: Clark & Elbing LLP

20080299643 - Systems and methods for large-scale production and harvesting of oil-rich algae: Systems and methods for the growing of microorganisms such as algae, yeast, and bacteria are described. Seed fermentation units are associated with final fermentation ponds in various arrangements. Continuous, semicontinuous, fed batch, and batch modes of operation of the seed and final fermentations are included. Harvest methods for the cellular... Agent: Sonnenschein Nath & Rosenthal LLP

20080299644 - E.coli mutant containing mutant genes related with tryptophan biosynthesis and production method of tryptophan by using the same: The present invention relates to a Tryptophan-producing E. coli mutant strain CJ285 (KCCM-10534) containing single or multi mutant genes related with Tryptophan biosynthesis and production method of Tryptophan using the same. More particularly, DNA base sequences and amino acid sequences aroF, aroG, trpR, and tyrR originated from tryptophan producing E.... Agent: Buchanan, Ingersoll & Rooney PC

20080299645 - Novel method for growing cordyceps sinensis on a substrate and novel method for hybridizing different strains of cordyceps sinensis: Strains of Cordyceps sinensis, are grown in a substrate at 20 to 22° C. at sea level atmospheric pressure for 28 to 30 days in diffuse light, and thereafter in an atmosphere containing approximately 50% of oxygen of the sea level atmosphere, at approximately 3° C. with exclusion of light,... Agent: Gabor L. Szekeres

20080299646 - Process for producing polysaccharide gum: The invention provides a process for producing polysaccharide gum comprising extracting a plant material with an aqueous solvent to produce a polysaccharide gum-containing extract; contacting the extract with at least one proteolytic enzyme to at least partially digest proteins in the extract; adding an organic solvent to the extract to... Agent: Myers Bigel Sibley & Sajovec

20080299647 - Cell capturing plate, microinjection apparatus, and method of producing cell capturing plate: A cell capturing plate has a flat surface, an opening formed in one surface of the flat surface and supporting the cell therein, and a through-hole penetrating from the opening to the other surface of the flat surface and having a cross section parallel to the flat surface smaller than... Agent: Staas & Halsey LLP

20080299648 - Diagnostic kit: The present invention relates to a diagnostic kit and more specifically to a self contained diagnostic kit providing analysis of a sample by a sample collectin element and an immunochromatography test strip.... Agent: Don J. Pelto Sheppard, Mullin, Richter & Hampton LLP

20080299649 - Cell culture apparatus for co-culture of cells: A multilayered cell culture apparatus for the co-culturing of at least two cell types is disclosed. The cell co-culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in... Agent: Corning Incorporated

20080299650 - Biological production of ethanol from waste gases: Apparatus for biological production of ethanol from waste gases includes a bioreactor including a plurality of tunnels each having inlet and outlet passageways, a gasifier reactor generates a continuous supply of syngas from waste gases into the upper portion of each tunnel. A mixing device provides a continuous supply of... Agent: Arthur G. Yeager, P.A.

20080299651 - Thermal cycle for automatic performance of the polymerase chain reaction with close temperature control: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.... Agent: Kilyk & Bowersox, P.l.l.c.

20080299652 - Shaking apparatus for cell culture incubator or the like: An apparatus for shaking a plurality of vessels, for example in an incubator, has at least one rotatable support 10 (101,102) defining a plurality of support locations for vessels 50 at predefined positions 12 around an upright axis and the support or supports 10 are rotatable around the upright axis... Agent: John P. De Luca

20080299653 - Established cell lines from lymantria xylina: The present invention relates to Lymantria xylina cell lines established from pupal tissues of L. xylina Swinhoe, including NTU-LY-1, NTU-LY-2, NTU-LY-3, and NTU-LY-4. These four cell lines were confirmed to be newly established cell lines derived from L. xylina by random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) and isozyme analysis.... Agent: Birch Stewart Kolasch & Birch

20080299654 - Methods of inhibiting smooth muscle cell migration and proliferation: In particular embodiments, the present invention provides methods of inhibiting smooth muscle cell responses and methods of treating or preventing vascular proliferative disease caused by smooth muscle cell migration and proliferation. More specifically, smooth muscle cell responses are inhibited by introducing an agent into smooth muscle cells, wherein the agent... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080299655 - Methods of tissue repair and regeneration and tissue engineered compositions: Provided are methods and compositions for constructing stable mammalian embryonic epithelial tissues and organs as well as constructing kidney tissue, and treating renal failure. Disclosed are methods of using an active epithelial growth factor having the capability of effectuating induction of growth and morphogenesis is cells.... Agent: Gavrilovich Dodd & Lindsey LLP Joseph R. Baker, Apc

20080299656 - Isolation of multi-lineage stem cells: The present application discloses a method of manipulating a biological sample of cells, which includes multi-lineage stem cells, progenitor cells, other marrow stromal cells: allowing the sample of cells to settle in a container; transferring supernatant from the container to another container; and isolating cells from the supernatant, which has... Agent: Jhk Law

20080299657 - Aligned nanofibers and related methods of use: The present invention relates to nanofibers. In particular, the present invention provides aligned nanofiber bundle assemblies. In some embodiments, the aligned nanofiber bundle assemblies are used for tissue regeneration, controlled growth of cells, and related methods (e.g., diagnostic methods, research methods, drug screening).... Agent: Casimir Jones, S.c.

20080299658 - Highly transformable elite doubled haploid line phwvz: A novel double haploid maize line designated PHWVZ and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing double haploid maize line PHWVZ with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into... Agent: Pioneer Hi-bred International, Inc.

20080299659 - Nucleic acid compounds for inhibiting apob gene expression and uses thereof: The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing ApoB gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to an... Agent: Nastech Pharmaceutical Company Inc Mdrna, Inc.

20080299660 - Methods for transfecting natural killer cells: Methods for stably transfecting mammalian natural killer cells comprising: transfecting a packaging cell line with a retroviral expression vector; culturing the transfected packaging cell line in a cell culture medium; and culturing the mammalian natural killer cells with the cell culture medium. Natural killer cells transfected according to the disclosed... Agent: Calfee Halter & Griswold, LLP

20080299661 - Cloning and/or sequencing vector: A cloning and/or sequencing vector enables recombinant clones to be selected directly. The vector encodes a fusion protein which includes a protein poison.... Agent: Knobbe Martens Olson & Bear LLP

20080299662 - Method for mrna stabilization: A method to increase the production of a desired chemical compound in a microorganism by introduction of a DNA sequence at the 5′ end of the encoding DNA gene sequence capable of forming a stem loop and capable of increasing the stability of mRNA transcripts from one or more genes,... Agent: Nixon & Vanderhye, PC