Chemistry: molecular biology and microbiology inventions 11/08

20080293034 - Organ arrest, protection, preservation and recovery: The present invention relates to a composition for controlling viability of a tissue including a potassium channel opener or adenosine receptor agonist a compound for inducing local anaesthesia and a compound for reducing the uptake of water by a cell in the tissue. The present invention also relates to the... Agent: Venable LLP

20080293035 - Nucleic acid isolation: The present invention relates to a method of isolating nucleic acid from a blood sample, said method comprising: (a) selectively isolating leucocytes from said sample by binding said leucocytes to a solid support by means of a binding partner specific for leucocytes; (b) lysing said isolated leucocytes; and (c) binding... Agent: Invitrogen Corporation C/o Intellevate

20080293042 - Detection of contamination of municipal water distribution systems: A system for the detection of contaminates of a fluid in a conduit. The conduit is part of a fluid distribution system. A chemical or biological sensor array is connected to the conduit. The sensor array produces an acoustic signal burst in the fluid upon detection of contaminates in the... Agent: Lawrence Livermore National Security, LLC

20080293040 - Influenza b viruses with reduced sensitivity to neuraminidase inhibitors: An isolated influenza B virus which has reduced sensitivity to one or more neuraminidase (NA) inhibitors, wherein the reduced sensitivity to one or more NA inhibitors is associated with a residue in NA other than Ile at position 222, a residue in NA other than Ser at a position 250,... Agent: Schwegman, Lundberg & Woessner, P.A.

20080293038 - Method for determining resistance of hiv to nucleoside reverse transcriptase inhibitor treatment: The present invention provides methods and devices for predicting whether an HIV-1 is resistant to an antiviral drug based on the HIV-1's genotype. In one aspect, the invention provides methods comprising determining whether a mutation or combination of mutations associated with NRTI resistance are present, as disclosed herein, thereby assessing... Agent: Jones Day

20080293041 - Methods and devices for detection of the strain of a pathogen: Provided are methods and devices for determining the strain of a pathogen in a sample.... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080293036 - Monoclonal antibodies to hiv-1 and methods of using same: The present invention provides monoclonal antibodies to HIV-1 Vpr and hybridoma cell lines that produce the monoclonal antibodies to HIV-1 Vpr. Methods for use of such antibodies in the detection of HIV-1 infection are also provided.... Agent: Townsend And Townsend And Crew, LLP

20080293037 - Sequences diagnostic for shrimp pathogens: Primers have been isolated that are diagnostic for the detection of the infectious hypodermal and hematopoietic necorsis virus (IHHNV). The primers are based on a new portion of the IHHNV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080293039 - Vp7 gene of human rotavirus and composition for diagnosis of human rotavirus infection comprising primer or probe specific to thereof: The present invention relates to a VP7 gene of human rotavirus and a composition for diagnosis of human rotavirus infection comprising primer or probe specific to thereof, and more particularly to a VP7 gene encoding the amino acid sequence set forth in SEQ ID NO:2 and a composition for diagnosis... Agent: Buchanan, Ingersoll & Rooney PC

20080293051 - proximity ligation assay: The present invention relates to compositions and methods for sensitive, rapid and convenient assays to detect and/or quantify one or more target using ribonucleic acid as probes, wherein the method includes binding a first and a second ribonucleic acid probe, each of which binds specifically to the target, wherein the... Agent: Chalker Flores, LLP

20080293058 - Association of gstm1 with autism and assays and methods based thereon: The present invention provides novel markers and assays for autism based on the association of GSTM1 with autism. The invention relates to the use and application of as a susceptibility marker for autism. GSTM1 may be combined with other markers in methods and assays for diagnosis, prenatal diagnosis, and assessment... Agent: Klauber & Jackson

20080293057 - Detection of unspecified genetically modified organism (gmo) on micro-arrays: The present invention is related to a method, kit and computer program for detecting the presence in a sample of an unspecified Genetically Modified Organism (GMO).... Agent: Knobbe Martens Olson & Bear LLP

20080293050 - Gene analysis for determination of a treatment characteristic: An apparatus, device, methods, computer program product, and systems are described that determine at least one amino acid sequence alteration of an amino acid sequence of a disease associated polypeptide, relative to an amino acid sequence of a corresponding non-disease associated polypeptide, identify a sub-sequence in the amino acid sequence... Agent: Searete LLC Clarence T. Tegreene

20080293054 - Hmgcr isoforms in prediction of efficacy and identification of cholesterol-modulating compounds: The present invention provides methods for assessing a subject's responsiveness to a HMGCR inhibitor therapy, and selection of a HMGCR inhibitor therapy based upon such methods. The invention further provides methods for identifying agents that modulate HMGCR activity, e.g., through modulating HMGCR mRNA splicing, while avoiding elevation of the statin-resistant... Agent: Bozicevic, Field & Francis LLP

20080293055 - K-ras mutations and anti-egfr antibody therapy: The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080293070 - Markers for memory t cells and uses thereof: Methods, uses, products and kits are described relating to monitoring, assessing and modulating immune function and more particularly memory T cell function. Methods of identifying agents for such modulation are also described, as well as uses of such agents for modulating immune function.... Agent: Wells St. John P.s.

20080293044 - Melks as modifiers of the rac pathway and methods of use: Human MELK genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of MELK are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20080293072 - Method for enumeration of mammalian micronucleated erythrocyte populations, while distinguishing platelets and/or platelet-associated aggregates: A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a second fluorescent labeled antibody having binding specificity for a surface marker for platelets, and a nucleic... Agent: Nixon Peabody LLP - Patent Group

20080293056 - Method for preparing cancer stem cells: The present invention provides a method for preparing cancer stem cells including the step of subjecting normal cells to Ras activation and p53 deficiency; the cancer stem cells prepared by the preparation method; a method for screening a cancer stem cell-targeting substance and a method for screening an anti-cancer substance... Agent: Studebaker & Brackett PC

20080293047 - Method for the diagnosis of aspirin intolerance: e

20080293043 - Method of detecting metastisizing cancer cells originating in stomach cancer: Metastatic cancer cells originating from gastric cancer are detected by a method comprising the step of collecting a biological sample from a subject, the step of detecting the presence of at least either aldehyde dehydrogenase or dopa decarboxylase in the biological sample of the subject, and the step of determining... Agent: Alston & Bird LLP

20080293059 - Method of identifying induced variability in in vitro cultures: The subject of the present invention is a method of identifying variability induced in in vitro cultures. The subject of the present invention may be used in the production of genetically stable lines, eg. of doubled haploids (determination of their genetic-apigenetic variability level), as well as facilitating a broadly understood,... Agent: Walker & Jocke, L.p.a.

20080293048 - Methods and kits based on ugt1a7 promoter polymorphism: The present invention relates to methods for predicting the efficacy, safety and toxicity of substances, e.g. of drugs and prodrugs. Furthermore, the present invention relates to a method for the stratification of mammalians for the treatment of a disease. Moreover, the present invention provides for kits and its use for... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20080293060 - Methods and compositions for identification of hydrocarbon response, transport and biosynthesis genes: Disclosed is a method using an alkane response element (ARE) from, e.g., Acinetobacter spp. to (i) identify and clone hydrocarbon biosynthesis genes, (ii) identify and clone hydrocarbon transporter genes (iii) identify and clone hydrocarbon response genes. Screening cells were developed that expressed a transcriptional activator, e.g., alkR, and included a... Agent: Fenwick & West LLP

20080293068 - Methods for engineering polypeptide variants via somatic hypermutation and polypeptide made thereby: Methods using somatic hypermutation (SHM) for producing polypeptide and nucleic acid variants, and nucleic acids encoding such polypeptide variants are disclosed. Such variants may have desired properties. Also disclosed are novel polypeptides, such as improved fluorescent proteins, produced by the novel methods, and nucleic acids, vectors, and host cells comprising... Agent: Townsend And Townsend And Crew, LLP

20080293049 - Methods, kids and polynucleotides for simultaneously diagnosing viruses: The present invention provides a simultaneous method for diagnosing HBV, HCV and HIV of a suspected patient. The present invention further provides different primer sets and specific probes for HBV, HCV and HIV. The present invention also provides a kit for simultaneous diagnosing of HBV, HCV and HIV.... Agent: Wpat, PC Intellectual Property Attorneys

20080293061 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080293062 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080293063 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080293064 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080293065 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080293066 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080293067 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080293069 - Rapid prognostic assay for malignancies treated with epidermal growth factor receptor: A molecular assay for determining the sensitivity or resistance of malignancies to chemotherapy prior to initiation of chemotherapy and which also allows for monitoring the therapeutic effects of the chemotherapy during treatment. The molecular assay measures tumor response to therapy with EGFR modulators and utilizes tumor mRNA as a starting... Agent: Hoxie & Associates LLC

20080293045 - Recombinase polymerase amplification: This disclosure describes related novel methods for Recombinase-Polymerase Amplification (RPA) of a target DNA that exploit the properties of recombinase and related proteins, to invade double-stranded DNA with single stranded homologous DNA permitting sequence specific priming of DNA polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo Attn: Patent Intake Customer No. 35437

20080293046 - Rna detection assays: The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a... Agent: Casimir Jones, S.c.

20080293071 - Sequencing and genotyping using reversibly terminating nucleotides: The invention provides a method of determining the nucleotide sequence of a target nucleic acid using a reversibly terminating nucleotide that is modified at the 2′ position.... Agent: Roche Molecular Systems, Inc. Patent Law Department

20080293053 - Shrna materials and methods of using same for inhibition of dkk-1: Methods and compositions for the treatment of soft tissue cancer are described. More specifically, the invention demonstrates that inhibiting or otherwise decreasing the activity of DKK-1 using shRNA or siRNA molecules will be effective at reducing the cancer phenotype of prostate cancer cells.... Agent: Marshall, Gerstein & Borun LLP

20080293052 - System and method for authenticating sports identification goods: A method for authenticating and verifying garment to be genuine is described. The method for authenticating a garment comprises applying a particular nucleic acid material/marker associated with a particular sequence of nucleic acid bases to a dye or paint and applying the marker to the garment. The method also comprises... Agent: Virtual Legal, P.C. Michael A. Kerr

20080293074 - Hemoglobin derivative measurement method, and reagent composition, measurement kit, analysis device and analysis system for use in the method: A sample solution including blood components is processed with a denaturalization reagent comprising a nonionic surface-activating agent and an oxidizing agent to denaturalize a hemoglobin derivative in the sample solution, and thereafter, an immunoassay is performing utilizing an antibody that is specific to a denaturalized site of the hemoglobin derivative... Agent: Steptoe & Johnson LLP

20080293075 - Method and composition for analyzing a carbohydrate polymer: Disclosed is a method for characterizing carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080293073 - Methods for assessing cdk5 activation and function: As described herein, signaling events occurring in neurons or at neuronal synapses have been identified that involve Cdk5 and various other molecules which bind to, are activated by, and/or activate Cdk5. Of particular relevance are interactions that stimulate calpain cleavage of p35 into p25, which binds Cdk5 in pathologic states.... Agent: Fulbright & Jaworski L.L.P.

20080293076 - Method to improve barrier function of cell-cell junctions: Described are methods of increasing the barrier function of a cell-cell junction, comprising activating a PDZ-GEF2 protein, wherein the PDZ-GEF2 protein comprises an amino acid sequence encoded by a gene corresponding to the RapGEF6 gene. Further described are methods for selecting an activator of PDZ-GEF2, comprising contacting a plurality of... Agent: Trask Britt

20080293077 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic and other uses: The invention relates to the discovery and characterization of several genes and the polypeptides they encode: thymotaxin (Tango-45), Tango-63d, Tango-63e, Tango-67, and huchordin (Tango-66). Thymotaxin is a new member of the C-C family of chemokines. Tango-63d and Tango-63e are two novel polypeptides within the tumor necrosis factor (TNF) receptor superfamily.... Agent: Millennium Pharmaceuticals, Inc.

20080293079 - Chip for diagnosing the presence of candida: The present invention concerns means and methods of detection of Candida and Candida-related fungal cells in clinical material by means of protein biochips.... Agent: Darby & Darby P.C.

20080293080 - Active immunization using a siderophore receptor protein: The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are... Agent: Mueting, Raasch & Gebhardt, P.A.

20080293078 - Method for the detection of atp in a sample with the aid of luminescene and a computer programme for that purpose: The present invention relates to a method for detecting ATP in a sample by using luminescence, wherein a luminescence reagent is added to the sample that has not undergone any pre-treatment with an extractant in order to effect the formation of an ATP complex, wherein the luminescence of the ATP... Agent: Foley And Lardner LLP Suite 500

20080293081 - Fluorescence polarization assays for acetyltransferase/deacetylase activity: Provided are methods for determining the activity of proteins that modulate the acetylation state of a protein substrate. The methods may be used for determining both acetyltransferase activity and deacetylase activity. The methods involve fluorescence polarization measurements for determining the acetylation state of a substrate peptide. The methods may also... Agent: Ropes & Gray LLP

20080293082 - Instrument: A method and apparatus for performing a first measurement on a biological fluid or control, which first measurement varies with both the concentration of a first component and at least one of the presence and concentration of a second component. The method and apparatus perform a second measurement on the... Agent: Barnes & Thornburg LLP (roche)

20080293084 - Fluorescence polarization assays for determining clostridial toxin activity: The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage... Agent: Allergan, Inc.

20080293085 - Fluorescence polarization assays for determining clostridial toxin activity: The present invention provides a method of determining the presence or activity of a clostridial toxin by (a) treating with a sample, under conditions suitable for clostridial toxin protease activity, a clostridial toxin substrate which includes a fluorophore; a bulking group; and a clostridial toxin recognition sequence containing a cleavage... Agent: Allergan, Inc.

20080293083 - Method and kit for peptide analysis: The present invention relates to a method for peptide analysis, comprising the following steps: a) tagging N-terminals of peptides in sample(s) with mass tagging reagent(s) and mass balancing C-terminals of said peptides with mass balancing reagent(s), or vice versa; and b) mass spectrometry analysis of said peptides. The present invention... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20080293091 - Apparatus and methods for automated diffusion filtration, culturing and photometric detection and enumeration of microbiological parameters in fluid samples: A system providing non-intrusive, automated culturing and photometric detection for analyzing microbiological parameters is described. The system includes a sealed non-intrusive sample cuvette, a housing with an enclosable cover, systems for incubation and photometric detection mounted within the housing. The sample cuvette consists of a clear graduated optically transmitive container... Agent: Bereskin And Parr

20080293089 - Assays for modulators of parkin activity using novel substrates: The invention provides in vitro and cell-based assays for parkin activity, in which parkin-mediated ubiquitination of the S5a subunit of the 26S proteasome is measured, or ubiquitination of troponin 1. The assays may be used to screen for agents that modulate parkin protein ligase activity.... Agent: Townsend And Townsend And Crew, LLP

20080293090 - Automated semi-solid matrix assay and liquid handler apparatus for the same: An improved liquid handling machine capable of regulating the temperature of assay compounds in the automated preparation of culture trays for biological assays is disclosed. The machine includes a horizontally movable table positioned beneath a vertically movable head. The table is divided into a plurality of stations holding mixing trays,... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080293092 - Calcium channel proteins and uses thereof: Described herein are compositions and uses thereof related to Ca2+ release-activated Ca2+ (CRAC) channel activity. Also described herein CRAC channel modulators for treating diseases or conditions that would benefit from inhibition of SOC channel activity.... Agent: Wilson Sonsini Goodrich & Rosati

20080293086 - Real time monitoring of microbial enzymatic pathways: This invention provides compositions and methods for monitoring and regulating the production of a target product of a biochemical pathway in an organism, such as butanol. A gene encoding a light-emitting reporter molecule, such as luciferase, is operatively linked with a transcription regulatory nucleotide sequence that regulates transcription of an... Agent: Wilson Sonsini Goodrich & Rosati

20080293087 - Sulfonylurea receptor short forms from mitochondria and uses thereof: The present invention relates to isolated sulfonylurea receptor polynucleotides and polypeptides, as well as vectors and cells lines containing the polynucleotides and polypeptides. The present invention also relates to methods of using cell lines containing the polynucleotides and polypeptides to identify agents that are useful in ischemic preconditioning.... Agent: Quarles & Brady LLP

20080293088 - Two-photon probe for real-time monitoring of intracellular magnesium ions, method for preparing the two-photon probe and method for real-time monitoring of intracellular magnesium ions using the two-photon probe: The two-photon probe is very suitable for real-time imaging of intracellular magnesium ions. The two-photon probe shows 17-fold two-photon excited fluorescence enhancement in response to Mg2+, which is 7-fold stronger than commercial probes, thus enabling staining of cells in a greatly reduced amount. In addition, the two-photon probe has a... Agent: Christie, Parker & Hale, LLP

20080293093 - Determining presence of antibiotic in a fluid: A test system for the determination of the presence of an antibiotic in a fluid using Bromthymol Blue as an indicator.... Agent: Nixon & Vanderhye, PC

20080293094 - Novel enzymatic substrates derived from phenoxazinone and their use as developer in detection of microorganisms with peptidase activity: t

20080293095 - Polydiacetylene-containing solid colorimetric and/or fluorescent detector, method for its preparation and uses thereof: A colorimetric and/or fluorescent detector, which comprises a film of polydiacetylenes and lipids deposited on a substrate, wherein said film is coated with one or more layers, wherein at least one of said layers is capable of supporting the growth of microorganisms. Also provided are processes for preparing the novel... Agent: Nixon & Vanderhye, PC

20080293096 - Enzyme and template-controlled synthesis of silica from non-organic silicon compounds as well as aminosilanes and silazanes and use thereof: The present invention relates to a method for synthesis of amorphous silicon dioxide (silica, condensation products of silicic acid) and other polymeric metal (IV) compounds from non-organic silicon compounds or metal (IV) compounds as well as from aminosilanes and silazanes, whereby (I) a template (collagen or another molecule, interacting with... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080293097 - Biological production of zeaxanthin and carotenoid biosynthesis control: The present invention relates to the isolation of carotenoids and in particular the xanthophyll zeaxanthin (zeaxanthin-β,β-Carotene-3,3′-diol) and optionally other carotenoids such as lycopene, β,β-carotene, 3′-hydroxyechinenone β-cryptoxanthin and the colourless carotenoids, phytoene and phytofluene from a marine bacterium belonging to the genus Algibacter which is capable of producing the aforementioned compounds.... Agent: Myers Bigel Sibley & Sajovec

20080293104 - proteases and methods for producing them: A secreted mature polypeptide derived from an S2A or S1E protease which after maturation has protease activity, which polypeptide when expressed and before maturation comprises a heterologous pro-region.... Agent: Novozymes North America, Inc.

20080293102 - Compositions and methods for producing apolipoprotein: The disclosure relates to recombinant nucleic acids, expression vectors comprising the recombinant nucleic acids, and host cells comprising the expression vectors for expressing a protein of interest.... Agent: Dechert LLP

20080293098 - Dna encoding novel enzyme having d-serine synthase activity, method of producing the enzyme and method of producing d-serine by using the same: This invention relates to DNA encoding a novel enzyme having activity of synthesizing D-serine from formaldehyde and glycine, recombinant DNA constructed by integrating such DNA into a vector, a transformant transformed with the recombinant DNA, and a method for producing D-serine from formaldehyde and glycine with the use of the... Agent: Buchanan, Ingersoll & Rooney PC

20080293101 - Engineered microorganisms for increasing product yield in biotransformations, related methods and systems: There are disclosed recombinant microorganisms engineered to increase product yield in a biotransformation. In an embodiment, the microorganisms are engineered to increase the amount of NAD(P)H available for a NAD(P)H-requiring oxidoreductase involved in a biotransformation. There are also disclosed methods and systems for using recombinant microorganisms engineered to increase the... Agent: Enrica Bruno Patent Law

20080293099 - Lignan glycosidase and utilization of the same: The present invention provides an enzyme having the lignan glycosidation activity by identifying the enzyme that is involved in the production of lignan glycosides, identifying the amino acid sequence of the enzyme polypeptide and the base sequence for a polynucleotide encoding the polypeptide, and based on the information of these... Agent: Drinker Biddle & Reath (dc)

20080293100 - Method for the fermentative production of l-amino acids with the aid of coryneform bacteria capable of using glycerin as the only carbon source: The invention relates to a method for producing L-amino acids in which the following steps are carried out: a) the recombinant coryneform bacteria which produce the desired L-amino acid and in which at least one or several of the heterologous polynucleotides of the glycerol metabolism, selected among the group comprising... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080293103 - Stress protein compositions and methods for prevention and treatment of cancer and infectious disease: Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an... Agent: Karen S. Canady Canady & Lortz LLP

20080293106 - Method for the mass production of immunoglobulin fc region deleted initial methionine residues: Disclosed is a method for the mass production of a monomeric or dimeric immunoglobulin Fc region, free of initial methionine residues, using a recombinant expression vector comprising a nucleotide sequence coding for a recombinant immunoglobulin Fc region comprising an immunoglobulin Fc region linked at the N-terminus thereof to an immunoglobulin... Agent: Arent Fox LLP

20080293105 - Recombinant method for making multimeric proteins: The present invention relates to methods for making multimeric proteins comprising fusion of two or more cells expressing a single subunit of the multimeric protein to generate a single hybrid cell expressing the fully assembled multimeric protein.... Agent: Marshall, Gerstein & Borun LLP

20080293107 - Methods for using riboprimers for strand displacement replication of target sequences: Methods, compositions and kits for amplifying a target sequence by strand displacement replication using strand-displacing primers. The method uses primers that have only ribonucleotides or purine ribonucleotides and at least one 2′-substituted pyrimidine-2′-deoxyribonucleotide.... Agent: Casimir Jones, S.c.

20080293108 - Hyaluronate synthase gene and uses thereof: Disclosed are DNA sequences encoding hyaluronic acid synthase that are employed to construct recombinant cells useful in the production of hyaluronata synthase and hyaluronic acid (HA). In preferred aspects, chromosomal DNA encoding the HA synthase gene, hasA, was cloned from a Streptococcus pyoganas genomic library. These vectors were used to... Agent: Dunlap Codding, P.C.

20080293109 - Methods for degrading or converting plant cell wall polysaccharides: The present invention relates to methods for converting plant cell wall polysaccharides into one or more products, comprising: treating the plant cell wall polysaccharides with an effective amount of a spent whole fermentation broth of a recombinant microorganism, wherein the recombinant microorganism expresses one or more heterologous genes encoding enzymes... Agent: Novozymes, Inc.

20080293110 - Process for isolation of mycophenolic acid: Mycophenolic acid can be isolated from fermentation broth easily with low consumption or organic solvents to produce mycophenolic acid that is surprisingly high in purity. The process can be accomplished by addition of a suitable base to the whole fermentation broth. i.e., a suspension obtained by submerged cultivation of a... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20080293111 - Process for the enzymatic preparation of citronellal: c

20080293113 - Process for production of succinic acid: Disclosed is a process for production of succinic acid, which comprises the step of reacting a bacterium which has been modified so as to increase the expression of a sucE1 gene or a product produced by any treatment of the bacterium with an organic raw material in a reaction solution... Agent: Greenblum & Bernstein, P.L.C

20080293112 - Succinic acid-producing bacterium and process for producing succinic acid: Coryneform bacterium is modified so that an activity of acetyl-CoA hydrolase is decreased, and succinic acid is produced by using the bacterium.... Agent: Greenblum & Bernstein, P.L.C

20080293114 - Method of continuous processing of lignocellulosic feedstock: A continuous process for treating a lignocellulosic feedstock is provided. This method comprises pretreating the lignocellulosic feedstock under pressure in a pretreatment reactor at a pH between about 0.4 and about 2.0. One or more than one soluble base is added to this pressurized, pretreated feedstock after it exits the... Agent: Fitzpatrick Cella Harper & Scinto

20080293115 - Plant wall degradative compounds and systems: The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080293117 - Heat resistant bioactive composition: A bioactive composition includes a hydrogel matrix. At least one protein is immobilized in the hydrogel matrix. The digestive protein has a half-life at least 1000 times longer than the half-life of a free digestive protein counterpart.... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

20080293116 - Ovary-specific genes and proteins: Ovary specific proteins O1 180, O1 184 and O1 236, polynucleotides encoding them, antibodies which are immunoreactive with them and vectors and host cells containing O1 180, O1 184 or O1 236 are provided. Also provided are methods for detecting cell proliferative or degenerative disorders of ovarian origin and which... Agent: Fulbright & Jaworski, LLP

20080293118 - Magnetic fine particles having lower critical solution temperature: The present invention relates to magnetic fine particles having a lower critical solution temperature to which at least one substance selected from biotin and avidin is immobilized, and a method of converting a substance, a method of separating or concentrating a microorganism, a method of modifying a denatured protein, a... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080293119 - B12 dependent dehydratases with improved reaction kinetics: Sequences of B12-dependent dehydratases with improved reaction kinetics are presented. Use of these B12-dependent dehydratases reduce the rate of the enzyme's suicide inactivation in the presence of glycerol and 1,3-propanediol. The enzymes were created using error-prone PCR and oligonucleotide-directed mutagenesis to target the DhaB1 gene, which encodes the α-subunit of... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080293120 - lipolytic enzymes variants: The inventors have developed improved polypeptides by substituting or deleting specified amino acids in fungal lipolytic enzymes. More particularly, the polypeptides result in a reduction of dough stickiness when they are added to a dough. The polypeptides may particularly have activity on polar lipids.... Agent: Novozymes North America, Inc.

20080293121 - Human dnase i hyperactive variants: The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive variants, thereby enabling the production of these variants in quantities sufficient for clinical use. The invention also relates to pharmaceutical compositions and therapeutic... Agent: Genentech, Inc.

20080293122 - Method for activating prethrombin-1: Methods for converting prethrombin-1 to thrombin are disclosed. An aqueous solution of prethrombin-1 is applied to oscutarin-C immobilized on a solid support so as to provide from 500 mg to 4000 mg of prethrombin-1 per mL of the solid support and a contact time between the prethrombin-1 and the oscutarin-C... Agent: Zymogenetics, Inc. Intellectual Property Department

20080293123 - Compositions comprising viruses and methods for concentrating virus preparations: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.... Agent: Townsend And Townsend And Crew, LLP

20080293125 - Engineered microorganisms for producing isopropanol: wherein at least one DNA molecule is heterologous to the microbial host cell and wherein the microbial host cell produces isopropanol. In another embodiment, a method is disclosed for the production of isopropanol including providing a recombinant microbial host cell, the host cell of (i) with a fermentable carbon substrate... Agent: Paul, Hastings, Janofsky & Walker LLP

20080293124 - Multimeric oxidoreductases: The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for the multimeric complexes and methods of use thereof.... Agent: Genencor International, Inc. Attention: Legal Department

20080293126 - Novel lactobacillus living body activating lactobacillus preparation and preventive or therapeutic agent for living body infection: This problem was resolved by developing a Lactobacillus casei species having the following key properties. (1) The species can be grown in the presence of any of one to four amino acids as a nitrogen source necessary for growth. (2) When a growth-promoting culture medium is inoculated with the species... Agent: Kratz, Quintos & Hanson, LLP

20080293127 - Method to render pressure sensitive adhesive compatible with polymerase chain reaction systems: A method for substantially eliminating a cross-linking element of a pressure sensitive adhesive by heating the pressure sensitive adhesive at a temperature of at least 180° C. for a period of time required to thermally decompose the cross-linking element of the pressure sensitive adhesive.... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080293129 - Fluid handling unit and fluid handling apparatus using same: A fluid handling unit 16 has an outside large-diameter cylindrical portion 16a, an outside small-diameter cylindrical portion 16b and an inside cylindrical portion 16c, which are integral-molded so as to be integrated with each other. The inside cylindrical portion 16c has a plurality of slits 16d, which are extend from... Agent: Bachman & Lapointe, P.C.

20080293128 - Sensor of pyrophosphate and snp typing sensor using the same: A sensor of pyrophosphate which is characterized by including: an insulative substrate 1; an electrode system that is formed thereon and has a measurement electrode 2 and a counter electrode 3; and a plurality of reaction reagent layers that are provided on the substrate 1 and include pyrophosphatase, glyceraldehyde-3-phosphate dehydrogenase,... Agent: Mcdermott Will & Emery LLP

20080293130 - Biochip: A biochip that can make optical measurements without being affected by background fluorescence etc., originating from the outside environment, wherein the surface of the substrate of the biochip can be chemically treated by a simple procedure. The biochip has at least a nontransparent resin substrate, an immobilizing layer formed on... Agent: Sughrue Mion, PLLC

20080293131 - Culture observation equipment: The present application includes a culture chamber, an observation chamber having an optical system of observation to observe samples to be cultured in the culture chamber, and a movement stage provided at a boundary which separates the culture chamber and the observation chamber, functioning as a wall to maintain an... Agent: Oliff & Berridge, PLC

20080293132 - High density bioreactor system, devices, and methods: A bioreactor and bioreactor system are suitable for the growth of materials from algae. More specifically, the system preferred embodiments use concentrated sunlight in a solo- or co-generation system to produce algae and products therefrom as well as solar thermal energy.... Agent: Miles & Stockbridge PC

20080293133 - Textiles for use in bioreactors for expansion and maintenance of cells: A bioreactor for three-dimensional culture of liver cells is disclosed. The device is characterized by the use of textile vasculatures. A model and method for optimizing vasculature parameters is also disclosed. Liver acinar structure and physiological parameters are mimicked by sandwiching cells in the space between the two innermost woven... Agent: Foley And Lardner LLP Suite 500

20080293134 - Human cancer suppressor gene, protein encoded therein, expression vector containing same: Disclosed are a human cancer suppressor gene, a proteins encoded therein, an expression vectors containing the same, and a microorganism transformed with the vector. The genes of the present invention may be useful to diagnose and prevent the human cancers.... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20080293135 - Co-culture bioreactor system: Disclosed are multi-chambered cell co-culture systems. The systems can be utilized to encourage the growth and development of isolated cells in a dynamic three-dimensional in vitro environment. The cell chambers (10) of the system can be in biochemical communication with adjacent chambers containing cells of different types, but the different... Agent: Dority & Manning, P.A.

20080293136 - Nucleic acid compounds for inhibiting akt gene expression and uses thereof: The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing AKT gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one strand is complementary to an... Agent: Nastech Pharmaceutical Company Inc Mdrna, Inc.

20080293137 - Compounds that abrogate dna damage induced cell cycle g2 checkpoint and/or augment anti-cancer activity of dna-damaging treatments: The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are... Agent: Pillsbury Winthrop Shaw Pittman LLP

20080293138 - Biologically active substance transfer sheet, cell culture kit constituted of cell culture plate and biologically active substance transfer sheet, producing method thereof and method for screening cell culture conditions utilizing the same: The invention provides a biologically active substance transfer sheet which can be formed with simple steps, a cell culture kit which comprises a cell culture plate and a biologically active substance transfer sheet, a producing method therefor, and a method for screening cell culture conditions with cells. The transfer sheet... Agent: Fitzpatrick Cella Harper & Scinto

20080293139 - Cell culture support for forming string-shaped cardiomyocyte aggregates: e

20080293140 - Propagation and/or derivation of embryonic stem cells: Embryonic stem (ES) cells are cultured in the presence of a compound which selectively inhibits propagation or survival of cells other than ES cells. The ES cells have not been genetically altered. Instead, the compound inhibits a signalling pathway which is essential for propagation of differentiated cells but is not... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080293141 - Cell for producing retrovirus vector: The N-acetylglucosaminyltransferase III activity is enhanced in a cell carrying retrovirus-origin gag-pol gene and env gene. By constructing a retrovirus vector with the use of the above cell, a retrovirus vector having a modified sugar chain structure can be obtained. The retrovirus vector constructed by this method shows a high... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080293142 - Multiple shrna expression vectors and methods of construction: A research or therapeutic tool for RNA interference (RNAi) is a single vector that expresses multiple short hairpin RNA (shRNA) sequences.... Agent: Fellers Snider Blankenship Bailey & Tippens

20080293143 - Generation of human embryonc stem-like cells using intronic rna: This invention generally relates to a method for developing, generating and selecting human embryonic stem (hES)-like pluripotent cells using transgenic expression of intronic microRNA-like RNA agents. More particularly, the present invention relates to a method and composition for generating a non-naturally occurring intron and its intronic components capable of being... Agent: Birch Stewart Kolasch & Birch

20080286745 - Methods and solutions for tissue preservation: Described herein are compositions and methods particularly useful in the medical arts. The compositions and methods may be used in connection with the preservation of a portion of a mammal, for example, tissues, organs, appendages, limbs, extremities, stem cells, myocytes, bone marrow, skeletal muscle as well as an array of... Agent: Davis Wright Tremaine LLP/los Angeles

20080286746 - Perfusion apparatus and method: A perfusion apparatus for perfusing an organ includes a pump for pumping perfusion liquid though a perfusion liquid conduit, the conduit having an outlet. A pressure sensor senses the pressure of the perfusion liquid downstream of the pump and upstream of the outlet. A controller controls the output of the... Agent: Akerman Senterfitt

20080286747 - Ex vivo methods for validating substance testing with human organs and/or tissues: Methods of validating results of assessments of test substances using human-derived tissues and/or organs, particularly tissues and/or organs unsuitable for transplantation, include assessing the suitability of the organ and/or tissue for substance testing, as well as inter-organ variability and use of exogenous and/or endogenous controls.... Agent: Oliff & Berridge, PLC

20080286748 - Blood collection tube with surfactant: Improvements in blood collection and testing. In one aspect, an improved method of manufacturing a blood collection tube, particularly illustrated for use in sedimentation rate testing, including providing an elongated glass tube with an open first end for receiving a venipuncture blood sample of at least 1 ml, formed with... Agent: Dobrusin & Thennisch PC

20080286749 - Enhanced protein expression using auto-induction media: Methods for refining the compositions of bacterial growth media to improve heterologous expression of desired recombinant target genes are provided. Also provided are compositions and culture media obtained using the above methods.... Agent: Warf/bhgl

20080286750 - Apparatus including ion transport detecting structures and methods of use: The present invention recognizes that the determination of ion transport function or properties using direct detection methods, such as whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and other fluidic components... Agent: Morrison & Foerster LLP

20080286756 - Compositions and methods for diagnosing and treating severe acute respiratory syndrome (sars): The present invention relates to the fields of immunochemistry and pharmacology. Methods and compositions are described for the diagnosis and treatment of SARS CoV infection. More specifically, the application discloses nucleic acids and peptides of the spike glycoprotein of SARS CoV that provide prognostic and therapeutic compositions in treatment of... Agent: Townsend And Townsend And Crew, LLP

20080286751 - Dispensing device for microfluidic droplets especially for cytometry: The invention relates to a dispensing device for droplets comprising a first channel (8, 10), known as main channel, for circulation of a first fluid flow, a second channel (12, 13) for circulation of fluid, which forms with the first channel an intersection zone (27) and terminates in an ejection... Agent: Thelen LLP

20080286759 - Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids: A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function... Agent: Loeb & Loeb, LLP

20080286755 - Immunoglobin igg3 as a marker for protecting against infectious viral diseases, and the uses of the same: The invention relates to a novel variant of isolated and/or purified immunoglobulin IgG3 which can be used as a marker for protecting against infectious viral diseases such as AIDS, as a diagnostic tool, or as a preventative and curative medicament. The invention also relates to corresponding in vitro diagnostic methods.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20080286757 - Method and apparatus for identification of microorganisms using bacteriophage: A sample is tested for the presence of bacteria, such as in an automatic blood culturing apparatus. If bacteria are determined to be present, a bacteriophage-based bacteria identification process is performed to identify the bacteria present. A plurality of bacteria detection processes, such as a blood culture test and Gram... Agent: Patton Boggs LLP

20080286752 - Methods for the production of hcv, assaying hcv entry, and screening drugs and cellular receptors for hcv: The invention provides cell culture methods that efficiently produce new infectious HCV virions where such methods are based on the unexpected finding that culturing cells at lower temperatures, i.e., from about 20° C. to about 34° C., enables efficient methods dependent upon HCV E1E2 mediated fusion. The invention also provides... Agent: Wilmerhale/new York

20080286754 - Mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance: The invention provides novel mutations, mutation combinations or mutational profiles of HIV-1 reverse transcriptase and/or protease genes correlated with phenotypic resistance to HIV drugs. More particularly, the present invention relates to the use of genotypic characterization of a target population of HIV and the subsequent correlation of this information to... Agent: Philip S. Johnson Johnson & Johnson

20080286758 - Reagents and kits for detection of influenza virus and the like: The present invention relates to reagents and methods for influenza virus detection. These reagents and methods disclosed in the present invention enable simple, rapid, specific and sensitive detection of influenza virus types A and B. These reagents are N-acetylneuraminic acid-firefly luciferin conjugates which can be cleaved by influenza virus neuraminidase.... Agent: Millen, White, Zelano & Branigan, P.C.

20080286753 - Wicking cassette method and apparatus for automated rapid immunohistochemistry: A sample processing system that may be configured to achieve automatic withdrawal of a substance at the end of appropriate processing sequences such as histochemical processing may involve a plurality of samples for which substances removed by moving a wicking cartridge that may have sequentially advanced absorbsant material on rolls... Agent: Santangelo Law Offices, P.C.

20080286797 - Accurate identification of organisms based on individual information content: An improved method for specific identification of any organisms by DNA hybridization or amplification is disclosed. Oligonucleotides are designed based on information analysis of sequences from a large number of related species. Oligonucleotide sequences that have the maximal specificity to certain nucleic acids from a particular species (or set of... Agent: Lathrop & Gage Lc

20080286782 - Analysis of dna samples: The invention provides an improved method for obtaining information about DNA analysis of samples of uncertain origin by establishing the likelihood that they arose in certain manners compared with other possible manners. In this way all of the analysis information is taken into account and likelihood ratios are provided to... Agent: Merchant & Gould PC

20080286766 - Comparing method for expression amount of the same gene from different sources by base sequence measurement: The present invention relates to an analysis method used to quantitatively compare the expression levels of the same gene from different sources. The method of the present invention can be used to quantitatively compare the gene expression level difference of the same gene of tissues or cells from different sources,... Agent: GlobalIPServices

20080286781 - Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer: The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are also provided.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080286798 - Controls for primers in multiplex amplification reactions: The present invention provides methods and compositions for confirming the integrity of primers and other components of amplification reactions, including multiplex amplification reactions.... Agent: Townsend And Townsend And Crew, LLP

20080286770 - Dna molecules encoding l-glutamate-gated chloride channels from rhipicephalus sanguineus: The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Rhipicephalus sanguineus glutamate gated chloride channels. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding R. sanguineus glutamate gated chloride channels, substantially purified forms of associated R. sanguineus... Agent: Judy Jarecki-black, J.d., Ph.d.

20080286762 - Gene detection field-effect device and method of analyzing gene polymorphism therewith: A gene detection field-effect device provided with an insulation film (2), a semiconductor substrate (3), and a reference electrode (4), includes:(a) the insulation film (2) including a nucleic acid probe (5) immobilized on one of the surfaces thereof and is in contact with a sample solution (6) containing at least... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080286796 - Genetic polymorphisms associated with neurodegenerative diseases, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic... Agent: Celera Corporation

20080286789 - Genomic polymorphism for predicting therapeutic response: The present invention relates to the use of genomic polymorphism to provide individualized therapeutic regimens to treat patients suffering from diseases such as cancer. The invention discloses methods for determining the efficacy or choice of chemotherapeutic drugs and regimens for use in treating a diseased patient by associating genomic polymorphism... Agent: Foley & Lardner LLP

20080286787 - High throughput method of dna methylation haplotyping: Particular aspects provide novel, high-throughput methods to quantify DNA methylation (e.g., at a single-base resolution) in an allele-specific manner. The methods comprise use of an allele-specific sequence polymorphism (e.g., allele-specific single nucleotide polymorphism; SNP) in sufficient proximity to a CpG methylation site to provide for distinguishing the methylation levels between... Agent: Davis Wright Tremaine, LLP/seattle

20080286779 - Host cells containing multiple integrating vectors: The present invention relates to the production of proteins in host cells, and more particularly to host cells containing multiple integrated copies of an integrating vector. Suitable integrating vectors for use in the present invention include retrovirus vectors, lentivirus vectors, transposon vectors, and adeno-associated virus vectors. Methods are provided in... Agent: Casimir Jones, S.c.

20080286765 - Human obesity susceptibility gene encoding a taste receptor and uses thereof: The present invention discloses the identification of a human obesity susceptibility gene, which can be used for the diagnosis, prevention and treatment of obesity and related disorders, as well as for the screening of therapeutically active drugs. The invention more specifically discloses that the TAS1R1 gene on chromosome 1 and... Agent: Fish & Richardson PC

20080286760 - Means and methods for the determination of camp in vitro and in vivo: The present invention relates to a chimeric peptide, comprising a cAMP binding moiety having only one cAMP binding site and at least two detectable labels, whereby the first of said two detectable labels is located at the carboxy terminus and the second of said two detectable labels is located at... Agent: Foley And Lardner LLP Suite 500

20080286800 - Method and system for biopsy and analysis of a body tissue: Methods and systems for performing biopsies and diagnosing tumors and suspect masses within the body. A biopsy sample is frozen while still in the body of a patient, then removed from the patient, stored frozen, and subject to IHC, microarray or other analysis to determine the amount, type or presence... Agent: Crockett & Crockett, P.C.

20080286784 - Method for detection of dna methyltransferase rna in plasma and serum: The methods of the invention detect in a qualitative or quantitative fashion DNA methyltransferase RNA in blood plasma, serum, and other bodily fluids. The inventive methods are useful for aiding detection, diagnosis, monitoring, treatment, or evaluation of neoplastic disease, and for identifying individuals who have a predisposition to disease or... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080286790 - Method for diagnosing overactive bladder: Techniques for diagnosing overactive bladder (OAB) in a patient are provided. For example, a technique for diagnosing overactive bladder in a patient includes the step of obtaining peripheral blood mononuclear cells (PBMC) from the patient to provide a reporter function in the patient.... Agent: Ryan, Mason & Lewis, LLP

20080286772 - Method for direct amplification from crude nucleic acid samples: The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the direct amplification of the nucleic acids in a crude sample with minimal sample purification.... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080286778 - Method for investigating cytosine methylations in dna: The invention relates to a method for sensitively and specifically detecting cytosine methylations. For this purpose, DNA is first analysed by reacting with the aid of a methylation specific restriction enzyme. In such a way, the background DNA is removed from a reaction preparation. At a next step, a specific... Agent: Kriegsman & Kriegsman

20080286801 - Method for the analysis of differential expression in colorectal cancer: A method for the analysis of differential expression in colorectal cancer based on the variation in the expression levels of genes encoding for proteins forming part of the condensin complex or associated proteins that occurs in patients with the disease and that can be used as markers for the diagnosis... Agent: Trask Britt

20080286763 - Method for the identification of sepsis: The invention relates to a method for the in vitro discrimination between systemic inflammatory non-infectious conditions and systemic inflammatory infectious conditions. The method comprises the following steps: a) sample RNA is isolated from a biological sample; b) the sample RNA and/or at least one DNA which represents a gene activity... Agent: Akerman Senterfitt

20080286773 - Method for typing an individual using short tandem repeat (str) loci of the genomic dna: The present invention relates to a novel STR typing strategy, which allows the simultaneous amplification and subsequent analysis of several (e.g. eleven) polymorphic systems with amplicon sizes of less than 270 bp. Thereby, after a PCR amplification the multiplex reaction is divided into two sets of STR multiplexes and analyzed... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080286793 - Method of analysis of primary structural change of nucleic acid: The object of the present invention is to offer a method for analyzing primary structure change of nucleic acid which has quantifiability, which has a high degree of sensitivity and reproducibility, and which can be conducted rapidly and at low cost. The method of analysis of primary structural change of... Agent: Scully Scott Murphy & Presser, PC

20080286767 - Method of analyzing dna sequence using field-effect device, and base sequence analyzer: e

20080286777 - Method of determining the diversity of t lymphocytes in a biological sample: The invention relates to the field comprising the diagnosis of possible immune system disorders and the analysis of immune responses. In particular, the invention relates to a method of determining the diversity of T lymphocytes in a biological sample, based on the molecular analysis of the structure of the junctions... Agent: Morgan Lewis & Bockius LLP

20080286795 - Method of nucleic acid amplification: A nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer can then be annealed to another immobilized primer and the other primer can be extended. Both extended... Agent: Klauber & Jackson

20080286771 - Method of predicting the responsiveness of a tumour to erbb receptor drugs: The invention relates to a method of selecting a mammal having or suspected of having a tumour for treatment with an erbB receptor drug which comprises testing a biological sample from the mammal for expression of anyone of the genes listed in Table 1 or 2 as defined herein whereby... Agent: Morgan Lewis & Bockius LLP

20080286769 - Method of quantitative and/or comparative measurement of mrna expression levels in small biological samples: The present invention provides a method for quantitative and/or comparative assessment of the relative amounts of mRNA transcripts present in a cell or tissue sample. In the method reverse transcription of the mRNA contained in the sample is first carried out using sequence-modifying primers for one or several genes in... Agent: Birch Stewart Kolasch & Birch

20080286785 - Method to predict or monitor the response of a patient to an erbb receptor drug: The invention provides a method of detecting ErbB receptor mutations comprising the steps of providing a bio-fluid sample from a patient; extracting DNA from said sample; and screening said DNA for the presence of one or more mutations that alter tyrosine kinase activity in the receptor.... Agent: Edwards Angell Palmer & Dodge LLP

20080286776 - Methods and compositions for assessment of pulmonary function and disorders: The present invention provides methods for the assessment of risk of developing lung cancer in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing lung cancer, and the suitability of a subject for... Agent: Sonnenschein Nath & Rosenthal LLP

20080286761 - Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders: The following application provides methods and nucleic acids for the detection of and/or differentiation between prostate cell proliferative disorders. This is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.... Agent: Davis Wright Tremaine, LLP/seattle

20080286794 - Methods and primers for diagnosing idiopathic congenital central hypoventilation syndrome: The present invention provides assays and kits for diagnosing idiopathic congenital central hypoventilation syndrome. The present assays and kits focus on the second polyalanine repeat of the PHOX2b gene or gene product, which is normally 20 residues in length. A polyalanine repeat 25 to 33 residues in length is strongly... Agent: Barnes & Thornburg LLP

20080286799 - Methods of and kits and compositions for diagnosing colorectal tumors...: In vitro methods of determining whether or not an individual has metastasized colorectal cancer cells are disclosed. In vitro methods of determining whether or not tumor cells are colorectal in origin are disclosed. In vitro kits for practicing the methods of the invention and to reagents and compositions useful to... Agent: Pepper Hamilton LLP

20080286775 - Methods of nonspecific target capture of nucleic acids: Methods for capturing a target nucleic acid from a sample by using a capture probe that binds nonspecifically to the target nucleic acid and binds specifically to an immobilized probe via a specific binding pair that has one member on the capture probe and one member on the immobilized probe... Agent: Gen Probe Incorporated

20080286786 - Methods of preparing nucleic acid for detection: Methods of preparing nucleic acid from polysaccharide-containing samples for detection by providing one or more glycosidases to the sample to degrade polysaccharides are provided. The nucleic acids can further be extracted from the sample. The method is particularly useful for detecting nucleic acid in samples with high starch content.... Agent: Brinks Hofer Gilson & Lione

20080286780 - Novel compositions and methods for the identification, assessment, prevention and therapy of human cancers: The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080286783 - Novel method of detecting genetic polymorphism: Provided is a method of determining the genotype of a subject in a genomic region comprising an SNP site, comprising a step for performing typing of the SNP site by the invader assay with a DNA-containing sample comprising the genomic region from the subject as the template, wherein fluorescence is... Agent: Leydig Voit & Mayer, Ltd

20080286788 - Nucleic acid ligands to complex targets and uses thereof: The present invention relates to a method for isolating a pool of nucleic acid ligands capable of binding to one or more target molecules in a complex mixture.... Agent: Birch Stewart Kolasch & Birch

20080286791 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080286792 - Probe, probe set, probe carrier, and testing method: A probe, a set of probes, and a probe carrier on which the probe or the set of probes is immobilized, are provided for classification of fungus species. The probe or the set of probes is capable of collectively detecting fungus of the same species and distinguishingly detecting those fungus... Agent: Fitzpatrick Cella Harper & Scinto

20080286774 - Real-time individualized therapy evaluation: A method of individually optimizing drug therapy to a patient that includes the steps of administering a dose of a radiolabeled drug or fluorescent tags or drugs with inherent fluorescent properties to the patient in connection with chemotherapy, collecting a sample from the patient, analyzing the sample producing an analysis,... Agent: Lawrence Livermore National Security, LLC

20080286768 - Sequencing a polymer molecule: A method for sequencing a target polymer molecule comprises the steps of: (i) treating the target polymer with an agent that degrades sequentially at least one end of the target polymer; (ii) converting at least a portion of the degraded end of different degraded polymers into a readable signal sequence,... Agent: Blank Rome LLP

20080286804 - Melanoma antigens and their use in diagnostic and therapeutic methods: The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognoses a mammal afflicted with melanoma or metastata melanoma. This invention... Agent: Leydig, Voit & Mayer, Ltd.

20080286803 - Method for the functional determination of mannan-binding-lectin associated serine proteases (masps) and complexes thereof: This invention relates to the field of determining, assaying or quantifying activity of components of the complement system. More particularly, the invention relates to methods for detecting the presence or level of activity in a sample of mannan-binding-lectin associated serine proteases (MASPs) or complexes of such proteases with lectins and... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20080286802 - System and method for large scale detection of hazardous materials in the mail or in other objects: A system and method that enables early detection of hazardous materials, such as explosives and biological materials, in the early phases of mail handling or processing.... Agent: Burns & Levinson, LLP

20080286806 - Ligand for g-protein coupled receptor gpr43 and uses thereof: The present invention is related to the G-protein coupled orphan receptor GPR43 and the identification of short chain fatty acids as natural ligands of the receptor. The invention further relates to assays for the identification of agents that modulate GPR43 ligand binding and signalling activity, as well as compositions consisting... Agent: Edwards Angell Palmer & Dodge LLP

20080286807 - Methods and reagents for elimination or reduction of false positives in the analysis of a sample: Methods, apparatuses, and systems for eliminating or reducing false positives in assays are provided. More specifically, there is provided a method to absorb a false positive signal with an absorber in favor of detecting a true positive signal. Embodiments of the present invention include but are not limited to systems... Agent: Schwabe, Williamson & Wyatt, P.C. Pacwest Center, Suite 1900

20080286805 - Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use: Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080286813 - Antibody specific for mutant presenilin 1 and method of use thereof: The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcripts and products of these genes are useful in detecting and diagnosing... Agent: Ropes & Gray LLP

20080286814 - Biomarkers for detecting cancer: The disclosure features, inter alia, a variety of biomarkers (e.g., biomarker peptides), compositions, and kits for use in methods for diagnosing a cancer. The biomarkers can be used, e.g., in methods for detecting a cancer in a subject. In addition, the disclosure also features methods of selecting a therapy for,... Agent: Fish & Richardson PC

20080286815 - Spectrophotometric assay for human histone deacetylase 8: The present invention relates to the development of a novel assay for determining the activity of human histone deactylase 8 (HDAC8). As shown in FIG. 3, thioactyl-lysine-containing peptide is used as the substrate for the HDAC8-catalyzed dethioacetylation reaction. Thioacetate, which is formed during this reaction, is subsequently reacted with Ellman's... Agent: Roetzel And Andress

20080286809 - Methods: A method for identifying a compound expected to be useful in modulating a WNK (With No Lysine Kinase) isoform protein kinase activity, the method comprising the steps of (1) determining whether a test compound modulates the protein kinase activity of a WNK isoform polypeptide on the substrate SPAK (STE20/SPS1-related Proline-Alanine-rich... Agent: Sheridan Ross PC

20080286808 - Methods for production of unstructured recombinant polymers and uses thereof: The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these entities. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous... Agent: Wilson Sonsini Goodrich & Rosati

20080286810 - Use of inhibtors of glutaminyl cyclases for treatment and prevention of disease: Novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC, methods for screening for such effectors, and the use of such effectors and pharmaceutical compositions comprising such effectors for the treatment of conditions that can be treated by modulation of QC-activity. Preferred compositions additionally comprise inhibitors... Agent: Sonnenschein Nath & Rosenthal LLP

20080286812 - Alcohol oxidase-based enzyme-linked immunosorbent assay: Disclosed is an assay for detecting an analyte. The method includes the steps of contacting a solution suspected of containing the analyte with capture antibodies specific for the analyte, wherein analyte contained in the solution is captured by the capture antibodies. Then contacting the capture antibodies with a solution containing... Agent: Intellectual Property Department Dewitt Ross & Stevens S.c.

20080286811 - Cyr61 as a biomarker for diagnosis and prognosis of cancers of epithelial origin: Urinary Cyr61 protein levels are up regulated in patients that have cancers of epithelial origin, i.e. breast cancer and ovarian cancer. Accordingly, the present invention is directed to methods for prognostic evaluation, and diagnosis of cancers of epithelial origin. Further, the amount of Cyr61 protein detected in a urine sample... Agent: Goodwin Procter LLP Patent Administrator

20080286816 - Detection of methamphetamine group drugs: The present invention provides immunoassays which are highly specific for detection in biological samples of methamphetamine and other drugs of abuse of the methamphetamine group such as ecstasy and other ecstasy class drugs. More particularly, competitive assays are provided comprising: (a) contacting said sample with (i) a pseudoephedrine/carrier conjugate in... Agent: Morrison & Foerster LLP

20080286817 - Novel allergens and treatment: The present invention is related to novel nucleotide sequences encoding a louse allergen and a methods for diagnosing, treating and preventing lice infestation and associated allergic disease with the nucleotide sequences and protein allergen of the invention. The present invention also relates to kits for diagnostic assays.... Agent: Knobbe Martens Olson & Bear LLP

20080286818 - Blood sample handling methods for improved assays for myeloperoxidase: The invention provides a method for determining concentration of myeloperoxidase (MPO) in a human blood sample comprising: (a) providing a human peripheral blood sample stored under MPO preservation conditions; and (b) determining concentration of MPO in a plasma sample derived from the human peripheral blood sample. In a preferred embodiment,... Agent: Paul D. Yasger Abbott Laboratories

20080286819 - Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof: The present invention provides reagents, methods and systems for predicting the cytotoxic activity of an antibody or variant thereof comprising: determining a binding affinity of the antibody or variant thereof to a Fc activating receptor; determining a binding affinity of the antibody or variant thereof to a Fc inhibitory receptor,... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20080286820 - Novel phenoxazinone derivatives as enzyme substrates and use thereof as indicator in the detection of microorganisms with peptidase activity: e

20080286829 - Apparatus and method for detecting live cells with an integrated filter and growth detection device: A device for rapid concentration and detection of live cells in fluids includes a filter to capture a cell sample. The filter includes a first physical barrier with apertures of a first size and a second physical barrier with apertures of a second size smaller than the first size to... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080286823 - Apparatus and method to measure platelet contractility: An apparatus and method for measuring blood platelet contractility, hereinafter called a “retractometer” is disclosed. Also disclosed is a system apparatus and method for automatically measuring platelet contractility in a plurality of samples, having an array of retractometer units and an electronic solenoid valve controller to fully automate screening in... Agent: Fuess & Davidenas

20080286827 - Biomarkers: The invention relates to biomarkers for use in diagnosing cancer and in classifying tumors.... Agent: Myriad Genetics Inc. Intellecutal Property Department

20080286826 - Luminescent particle and method of detecting a biological entity using a luminescent particle: The invention provides a luminescent particle (10) and a method of detecting a biological entity using a luminescent particle, the luminescent particle comprising a core area (20) and a shell area (30), the core area (20) being covered by the shell area (30), the core area (20) conferring a luminescent... Agent: Philips Intellectual Property & Standards

20080286828 - Materials and methods relating to g-protein coupled receptor oligomers: The invention provides materials and methods relating to G-protein coupled receptor (GPCR) oligomers. Complexes of two or more GPCRs associated with G-proteins are provided. Also provided are fusion proteins comprising a GPCR and a G-protein, nucleic acids, expression vectors and host cells. Methods of producing the complexes and fusion proteins... Agent: Bozicevic, Field & Francis LLP

20080286825 - Methods for diagnosing and monitoring the progression of cancer: Methods for measuring c-Met levels in urine and blood samples are provided. Methods for diagnosis and prognosis evaluation for cancer are also provided.... Agent: Woodcock Washburn LLP

20080286821 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Knobbe, Martens, Olson & Bear, LLP

20080286824 - System for screening cells for high expression of a protein of interest (poi): This invention refers to industrial production of proteins. More particularly, the invention refers to a fusion protein as a novel chimeric selection marker comprising a peptide conferring resistance to an antibiotic, or a fragment, allelic variant, splice variant or mutein thereof, and at least one sequence comprising SEQ ID NO:... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080286822 - Systems and methods for detecting toxins in a sample: In one aspect the invention provides a system for detecting the presence of toxins in a sample that includes a plurality of chambers for culturing organisms and observing the organism's motility response when introduced into a sample containing a toxin. The toxicity measurement system may include an imaging module to... Agent: Ropes & Gray LLP

20080286830 - Analysing breath samples for volatile organic compound: The invention describes the use of a biomarker pentylfuran to detect bacterial and/or fungal pathogens. Pentylfuran is released from certain pathogens and detected in the headspace gas of an in vitro culture or in the breath sample of a patient. Pentylfuran is particularly useful in the detection of Aspergillus species,... Agent: Knobbe Martens Olson & Bear LLP

20080286831 - Sample collector and tester: Provided are devices and methods for testing solid, semi-solid, or liquid animal or environmental specimens. The multi-part device comprises a breakable seal that separates a specimen treatment chamber from a testing chamber.... Agent: Grant Anderson LLP C/o Portfolioip

20080286833 - Expression vector, a transformant carrying the same and a method for producing heterologous protein: The present invention provides an expression for use in the fission yeast Schizosaccharomyces pombe, a transformant carrying the expression vector, a method for producing a heterologous protein using the transformant, in particular a method for producing a heterologous protein in which a heat shock protein gene promoter in Schizosaccharomyces pombe... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080286832 - Methods for obtaining optically active epoxides and vicinal diols from 2,2-disubstituted epoxides: The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific 2,2-disubstituted epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vectors containing such nucleic acid molecules, and cells containing such vectors. Also embraced by the invention are methods for... Agent: Fish & Richardson P.C.

20080286834 - Leader sequences for directing secretion of polypeptides and methods for production thereof: The present invention provides leader sequences that are useful for the production of heterologous secretable polypeptides; heterologous secreted polypeptides; nucleic acid constructs that encode such leader sequences and heterologous secreted polynucleotides; vectors that contain such nucleic acid constructs; recombinant host cells that contain such nucleic acid constructs; vectors, polypeptides, and... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080286835 - Isothermal amplification of nucleic acids: A process of amplifying a nucleic acid template dependent on partial destruction of primer molecules which have extended onto the template molecule followed by strand invasion of the partially destroyed primer template by a replacement primer. The destruction of the primer molecule may be performed by either endonuclease or exonuclease... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080286836 - Method and means for producing high titer, safe recombinant lentivirus vectors: Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the transgene enhances virus... Agent: Jones Day

20080286837 - Nucleotide analogs: The disclosure provides nucleotide analogs and methods of their use. Analogs of the invention comprise a reporter molecule (label) attached via the N4, N6, O4, or O6 position of the nitrogenous base portion of the analog. In a preferred embodiment, nucleotide analogs of the invention comprise a label attached to... Agent: Docketing Specialist Sullivan & Worcester LLP

20080286764 - Method of mass spectrometry: A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally... Agent: Waters Investments Limited C/o Waters Corporation

20080286838 - Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides: A shortened process for producing a solution containing substantially purified capsular polysaccharides from a cellular Streptococcus pneumoniae lysate broth is described. Ultrafiltering and diafiltering a clarified S. pneumoniae lysate followed by pH adjustment to less than 4.5, preferably about 3.5, precipitated at least 98% of the protein in the solution... Agent: Alston & Bird LLP

20080286839 - Container and method for production of biomembrane: A method and a container for production of a biomembrane are disclosed in the present invention. The biomembrane produced in the method and in the container of the present invention can be processed into a mask, wherein processes for changing the shape of the biomembrane are unnecessary. The mask produced... Agent: Bacon & Thomas, PLLC

20080286840 - Microorganisms comprising enzymes express with low gamma-elimination activity: A microorganism in which enzymes are expressed that have one or several of the following activities cystathionine-γ-synthases and/or phosphohomoserine sulfhydrylase and/or acylhomoserine sulfhydrylases and that have at the same time low γ-elimination activity is disclosed and also relates to recombinant enzymes that have one or several of the following activities... Agent: Ip Group Of Dla Piper US LLP

20080286841 - Pgro expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080286842 - Process for the production of macrolides using a novel strain, streptomyces sp. bicc 7522: The present invention discloses a new strain of Streptomyces sp. BICC 7522, its variants or mutants and use of the strain for the production of macrolides, process of production and purification of microlides.... Agent: Marjama Muldoon Blasiak & Sullivan LLP

20080286843 - Process for preparing 2-hydroxy-substituted pyridines: wherein R is a methyl group, a carboxyl group, a carbamoyl group, a hydroxyiminomethyl group or a cyano group, to obtain the corresponding 2-hydroxy-4-substituted pyridine compound. The novel microorganisms are the Delftia species YGK-A649 (FERM BP-10389), Delftia species YGK-C217 (FERM BP-10388), or Acidovorax species YGK-A854 (FERM BP-10387) and the novel... Agent: Heslin Rothenberg Farley & Mesiti PC

20080286844 - Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof: A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA,... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080286845 - Fermentation process: The present invention relates to processes of fermenting plant derived material into a desired fermentation product. The invention also relates to an antifoaming system for use in a fermentation process.... Agent: Novozymes North America, Inc.

20080286846 - Method and equipment for treating microcystin-containing water: The method for treating microcystin-containing water which detoxifies microcystin in the microcystin-containing water, the method comprises the step of: bringing the microcystin-containing water into contact with a Sphingomonas bacterium to degrade biologically the microcystin in the microcystin-containing water, wherein: the Sphingomonas bacterium is a strain FERM P-19480 which is deposited... Agent: Oliff & Berridge, PLC

20080286847 - Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules: A composition having an agent adapted to affect a multimeric protein by binding to a binding site of the multimeric protein and thereby affecting an equilibrium of units, wherein the multimeric protein has an assembly having a plurality of said units, wherein each of the units has a first complementary... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20080286848 - Recovery of recombinant human parainfluenza virus type 2 (hpiv2) from cdna and use of recombinant hpiv2 in immunogenic compositions and as vectors to elicit immune responses against piv and other human pathogens: Recombinant human parainfluenza virus type 2 (HPIV2) viruses and related immunogenic compositions and methods are provided. The recombinant HPIV2 viruses, including HPIV2 chimeric and chimeric vector viruses, provided according to the invention are infectious and attenuated in permissive mammalian subjects, including humans, and are useful in immunogenic compositions for eliciting... Agent: Birch, Stewart, Kolasch & Birch, LLP

20080286849 - Herbal extract having anti-virus activity and preparation of same: The invention relates to the herbal extract having anti-viral activity. More specifically, it relates to the herbal extract produced by extracting the comminuted Fructus Ligustri Lucidi (privet fruit), Rhizoma Polygonati (sealwort), Herba Agrimoniae (agrimonia), Radix Rehmanniae Glutinosae Conquitae (steamed glutinous rehmannia) or the mixture thereof, with a low polar solvent,... Agent: Bacon & Thomas, PLLC

20080286850 - Mdck cell lines supporting viral growth to high titers and bioreactor process using the same: The present invention relates to novel MDCK cells which can be to grow viruses, e.g., influenza viruses, in cell culture to higher titer than previously possible. The MDCK cells can be adapted to serum-free culture medium. The present invention further relates to cell culture compositions comprising the MDCK cells and... Agent: Medimmune, LLC Jonathan Klein-evans

20080286851 - Large-scale photo-bioreactor using flexible materials, large bubble generator, and unfurling site set up method: A closed photo-bioreactor, which in at least one example comprises a plurality of flexible, repeating, substantially enclosed, parallel chambers flexibly connected along their lengths, where a liquid growth media is substantially still without the need for turbulent mixing of the bulk liquid. In many examples, each is connected into integrated,... Agent: Arnold & Knobloch, L.L.P.

20080286852 - Electroporation of mycobacterium and overexpression of antigens in mycobacteria: Recombinant Mycobacterium strains with improved vaccinal properties for use as vaccinating agents are provided. The parent strains of the recombinant Mycobacterium strains are selected for their potent immunogenicity. The Mycobacterium strains do not display antibiotic resistance, and do not exhibit horizontal transfer to gram-negative bacteria.... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20080286853 - Process for producing a bio-pesticide composition containing trichoderma harzianum and pseudomonas fluorescens: A process for the production of organic and combination formulation of bio-pesticide containing Trichoderma harzianum and Pseudomonas fluorescens comprising preparation of mother culture, liquid fermentation as well as solid fermentation of T. harzianum, preparation of mother culture, liquid fermentation as well as solid fermentation of P. fluorescens separately, followed by... Agent: The Webb Law Firm, P.C.

20080286854 - Method for enriching lignocellulose residues with yeast protein: The invention relates to the use of sugar cane molasses and distillery slop for carrying out a method for enriching lignocellulose residue, especially bagasse or straw, with yeast protein. The invention also relates to said lignocellulose residue enrichment method, and to the product thus obtained.... Agent: Young & Thompson

20080286855 - Thermacetogenium phaeum consortium for the production of materials with enhanced hydrogen content: An isolated microbial consortium is described that includes a first microbial consortium having Thermacetogenium phaeum to metabolize a complex hydrocarbon substrate into metabolic products comprising an acetate compound. The consortium also includes a second microbial consortium having a methanogen to convert the acetate compound into a final product that includes... Agent: Townsend And Townsend And Crew, LLP

20080286856 - Nanostructure enhanced luminescent devices: The present invention relates to nanostructures for use in luminescent devices.... Agent: Woodcock Washburn LLP

20080286857 - Multi-functional polymer-entrapped-cell-bead airlift bioreactor for odor or gaseous emission treatment: The invention provides a multi-functional polymer-entrapped-cell-bead airlift bioreactor for odor or gaseous emission treatment. Especially, it refers to a reactor that mainly treats a low-and-medium gas flow rate and concentration of volatile organic emission or odorous substances. Particularly, it utilizes synthetic material (PAA beads) and microbial entrapment technology as the... Agent: Troxell Law Office PLLC

20080286858 - Reaction vessel with integrated optical and fluid control elements: The present invention provides disposable, semi-reusable, or single use reaction vessels with integrated optical elements for use with diffraction based assay systems. The vessel for assaying liquids for analytes includes a housing having at least one chamber or well for receiving a liquid therein and an optical element integrally formed... Agent: Ralph A. Dowell Of Dowell & Dowell P.C.

20080286859 - Apparatus for producing thin sections: An apparatus for producing flat thin sections of a specimen (3) comprises a blade edge (7), a specimen carrier (4), a drive device (14) for producing a relative motion between the blade edge (7) and the specimen carrier (4) in a sectioning plane (5), and a light light-ribbon micrometer (8)... Agent: Hodgson Russ LLP The Guaranty Building

20080286860 - Cancer specific promoters: The present invention regards cancer-specific control sequences that direct expression of a polynucleotide encoding a therapeutic gene product for treatment of the cancer. Specifically, the invention encompasses breast cancer-, prostate cancer-, and pancreatic cancer-specific control sequences. Two breast cancer-specific sequences utilize specific regions of topoisomerase IIα and transferrin receptor promoters,... Agent: Fulbright & Jaworski, LLP

20080286861 - Compositions and methods for the treatment of immune related diseases: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.... Agent: Goodwin Procter LLP

20080286863 - Method and solutions for cryopreserving oocytes, especially fresh human oocytes: In a method for cryopreserving fresh human oocytes, freezing and thawing solutions are used, which solutions include 1,2 propanediol (PROH) and sucrose at a concentration of at least 0.3M. The oocytes are exposed for 13-15 minutes to a solution including 1.5M PROH and 0.3M sucrose before starting the freezing process.... Agent: Klein, O'neill & Singh

20080286862 - Physiochemical culture conditions for embryonic stem cells: Physiochemical parameters to improve the culturing and sub-culturing (here called cloning) of human embryonic stem cells have been investigated. Low levels of oxygen and higher than expected levels of osmolarity in the culture medium have both been found to contribute to the improved culture of human stem cells.... Agent: Quarles & Brady LLP

20080286864 - Choroid plexus preparation and uses thereof: The present invention is directed to the use of choroid plexus cells and/or choroid plexus conditioned media for enhancing the growth, survival and/or maintenance of function of non-choroid plexus cells grown in long term or short term culture.... Agent: Greenlee Winner And Sullivan P C

20080286865 - Methods for the preservation of platelet efficacy during storage: Invented is a method for the preservation of human platelet lifespan and/or efficacy during storage which comprises the addition of an effective amount of a non-peptide TPO receptor agonists to a storage solution containing human platelets.... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20080286866 - Nucleic acid compounds for inhibiting vegf gene expression and uses thereof: The present disclosure provides meroduplex ribonucleic acid molecules (mdRNA) capable of decreasing or silencing VEGFA, VEGFB, VEGFC, FIGF, or PGF gene expression. An mdRNA of this disclosure comprises at least three strands that combine to form at least two non-overlapping double-stranded regions separated by a nick or gap wherein one... Agent: Nastech Pharmaceutical Company Inc Mdrna, Inc.

20080286867 - Method of inducing embryonic stem cells into pancreatic cells: The present invention provided a simple three-step approach based on the combinational induction with activin A, all-trans retinoic acid and, optionally, other maturation factors which are able to induce embryonic stem cells to differentiate into insulin-producing cells. A kit used to induce embryonic stem cells to differentiate into insulin-producing cells... Agent: Osha Liang L.L.P.

20080286868 - Metal binding compounds and their use in cell culture medium compositions: The present invention is directed generally to metal binding compounds which may be added to cell culture media to replace factors required for cultivation of the cells (e.g. transferrin) which are of animal or human origin. More specifically, the invention is directed to metal binding compounds or complexes thereof comprising... Agent: Invitrogen Corporation C/o Intellevate

20080286869 - Retroviral vector: Provided herein is a retroviral vector comprising, and capable of expressing, a nucleotide of interest (NOI), wherein the NOI encodes an RNA or protein which is harmful to a cell.... Agent: Frommer Lawrence & Haug

20080286871 - Modular genomes for synthetic biology and metabolic engineering: The invention provides methods and compositions for assembling a modular replacement genome in a host microorganism. After such assembly, the host organism's genome is inactivated or ablated to permit full control of host cellular functions by the replacement genome. A modular replacement genome comprises an assembly of nucleic acid fragments,... Agent: Bc Cancer Agency Technology Development Office

20080286870 - Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production: A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental by-product of xylose metabolism. It also consumes more xylose and produces more ethanol during mixed sugar... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080280282 - Method for early detection of various cancers and gastrointestinal disease and monitoring of transplanted organs: A method for the early diagnosis of breast, lung, pancreatic and colon growths and cancers as well as conditions associated with donor and recipient organ transplants, both before and after transplantation to identify and allow treatment of possible transplanted organ rejection and other disease conditions related and unrelated to the... Agent: Thorpe North & Western, LLP.

20080280281 - Method of altering the binding specificity of plasma proteins by oxidation-reduction reactions: The binding specificity of at least one plasma protein suspended or dissolved in a liquid medium is altered by exposing the protein to an oxidizing agent or an electric current sufficient to alter its binding specificity. A masked protein such as an autoantibody can be recovered from blood or blood... Agent: Antonelli, Terry, Stout & Kraus, LLP

20080280283 - Methods for assessing fatigue level and applications thereof: Level of fatigue that accompanies everyday life or a disease can be simply, easily, and quantitatively assessed by obtaining a body fluid from a test subject and measuring the amount of human herpesvirus in the body fluid. Furthermore, the anti-fatigue potency of anti-fatigue substances and anti-fatigue food products can be... Agent: Hunton & Williams LLP Intellectual Property Department

20080280284 - Nucleic acid sequences that can be used as primers and probes in the amplification and detection of hsv dna and method for the amplification and detection of hsv dna using a transcription based amplification: The present invention is related to a pair of oligonucleotide primers for the amplification of HSV nucleic acid comprising: a) an oligonucleotide, 10-50 nucleotides in length, preferably 10-35 nucleotides in length, comprising at least a fragment of 10 nucleotides of a sequence selected from the group consisting of: 5′-ACGTTCACCAAGCTGCTGCT-3′, or... Agent: Myers Bigel Sibley & Sajovec

20080280285 - Systems and methods for testing using microfluidic chips: Disclosed are methods, devices and systems for biological and chemical sample processing using microfluidic chips. The disclosed microfluidic chips contain at least two detection zones for interacting with pre-selected RNA sequences, DNA sequences, antibodies, or antigens to determine their presence in the sample. Systems are also described comprising a cassette... Agent: Woodcock Washburn LLP

20080280288 - Assay method to predict sensitivity of cancer cell to anticancer drug: If a cancer cell sampled from a cancer patient by biopsy or the like can be examined with respect to its expressed molecules to evaluate sensitivity of the cancer cell to the present compound, the present compound can be selectively administered only to the cancer patient who is expected to... Agent: Birch Stewart Kolasch & Birch

20080280297 - Compositions and methods for differential diagnosis of chronic lymphocytic leukemia: The invention provides compositions and methods for determining a prognosis of a B cell chronic lymphocytic leukemia (CLL) in a subject based on the level of expression of at least one marker gene. Marker genes provided by the invention are SEPTlO, KIAA0799, Hs.23133, and ADAM29. The marker genes can be... Agent: Wilmerhale/columbia University

20080280286 - Compositions and methods for gene expression: The invention provides nucleotide sequences that mediate one or more functions of IKKα, kits and methods for using these sequences to identify therapeutic compounds that alter IKKα related pathology.... Agent: Meden & Carroll

20080280291 - Compositions and methods utilizing dna polymerases: The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′ to 5′ exonuclease activity and/or exhibit reduced discrimination against non-conventional nucleotides relative to the wild-type form of the polymerase.... Agent: Agilent Techologies Inc

20080280303 - G-protein coupled receptors high-throughput functional assay: Disclosed herein are methods for enabling or improving functional assays of G-protein coupled receptors through the use of co-expression of helper genes. In some cases, chimeras linking the regulatory domain of the rap1B protein to the effector region of the ras oncogene are used in conduction with existing functional assays... Agent: Knobbe Martens Olson & Bear LLP

20080280294 - Inherited mitochondrial dna mutations in cancer: A method is provided for identifying a subject likely to have, or at risk of developing a disease condition correlated with increased reactive oxygen species (ROS), including cancer, by identifying in the subject a missense mutation in a nucleic acid of Complex III, IV and/or V of the OXPHOS system.... Agent: Greenlee Winner And Sullivan P C

20080280292 - Late-pcr: A non-symmetric polymerise chain reaction (PCR) amplification method employing a limiting primer in low concentration whose concentration-adjusted melting point at least equals, and preferably exceeds, that of the excess primer, the latter in turn not being more than 25° C. below the melting temperature of the amplicon. Assays employing such... Agent: Foley And Lardner LLP Suite 500

20080280301 - Lrp4/corin dopaminergic neuron proliferative progenitor cell markers: According to the present invention, Lrp4, a gene that is specifically expressed in dopaminergic neuron proliferative progenitor cells prior to cell cycle exit, was identified. The use of Lrp4 expression in cells as an index allows for the isolation. of cells suitable for transplantation therapy of neurodegenerative diseases such as... Agent: Townsend And Townsend And Crew, LLP

20080280300 - Method: There is described a method for identifying a potential modulator of a cell signalling pathway, comprising the steps of: (a) providing a cell of a first cell type, wherein said first cell type may be differentiated to a second cell type via a progenitor cell by sequentially exposing said first... Agent: Steptoe & Johnson LLP

20080280290 - Method and device for the collection and isolation of nucleic acid: A device for collecting and preserving nucleic acids in a sample, the device comprising: a) a support; b) one or more than one sample zone in the support for loading the sample onto the device; and c) a composition comprising i) one or more than one absorbent, and ii) one... Agent: Sheldon Mak Rose & Anderson PC

20080280304 - Method for detecting target plant genus: The method for detecting species in a target plant genus, particularly an allergenic plant genus such as the genus Fagopyrum, can make it possible to detect with high sensitivity, for example, about 1 ppm of the plant(s) in cases where the plant(s) is contained in a food ingredient or food... Agent: Hoffmann & Baron, LLP

20080280296 - Method for detection of foot-and-mouth disease virus with chromatographic strip test: The present invention discloses a method for detection of foot-and-mouth disease virus with chromatographic strip test. Firstly, the nucleic acid sequence of FMDV NSPs is set up, the nucleic acid sequence is amplified by the reverse transcriptase polymerase chain reaction (RT-PCR) method, the recombinant vector is constructed and performed through... Agent: Rabin & Berdo, PC

20080280299 - Method for specific detection of legionella pneumophila: A method for specific detection of the presence of Legionella pneumophila in a sample that is suspected to contain L. pneumophila and which further comprises one or more other microorganism(s).... Agent: Berenbaum, Weinshienk & Eason, P.c

20080280293 - Method of examining inflammatory disease and method of screening remedy for imflammatory disease: A gene polymorphism on a Toll-like receptor gene is analyzed and an inflammatory disease is examined based on the results of the analysis. A remedy for an inflammatory disease is screened by selecting a substance capable of altering the interaction between Toll-like receptor and galectin-2.... Agent: Birch Stewart Kolasch & Birch

20080280302 - Multigene diagnostic assay for malignant thyroid neoplasm: The present invention provides methods for diagnosing, providing a prognosis, and staging thyroid cancer, using panels of molecular markers that are differentially expressed in thyroid cancer. Also provided are methods to identify compounds that are useful for the treatment or prevention of thyroid cancer.... Agent: Townsend And Townsend And Crew, LLP

20080280287 - Oligonucleotides for the detection of hepatitis b virus: The invention relates to specific oligonucleotide primers and probes for rapid and sensitive detection of hepatitis B virus by amplification of the HBV nucleic acid, and to methods using the same. It is also concerned with kits useful to perform these detection tests.... Agent: Jacobson Holman PLLC

20080280289 - Primers, methods and kits for detecting killer-cell immunoglobulin-like receptor alleles: Embodiments of the present invention describe primer pairs, methods and kits for identifying and/or detecting killer-cell immunoglobulin-like receptor (KIR) alleles. The present primer sets include one or more primer pairs that can produce amplicons specific for an individual KIR allele and that are less than 1000 bp in size. Additionally,... Agent: Invitrogen Corporation C/o Intellevate

20080280298 - Satb1: a determinant of morphogenesis and tumor metastasis: It is proposed that cancer cells express SATB1, and that SATB1 acts as a determinant for the acquisition of metastatic activity by controlling expression of a specific set of genes that promote metastatic activity. In order for cancer cells to gain the ability to metastasize, SATB1 re-organizes or re-packages genomic... Agent: Townsend And Townsend And Crew, LLP

20080280295 - Use of panel of pairs of primers complementary to reporter genes of cell differentiation: The present invention to a panel comprising at least two pairs of primers that are complementary to at least two different reporter genes, the expression of which are i) either up- or down-regulated upon cell differentiation, and ii) display a similar expression profile in at least two different cell lines... Agent: Buchanan, Ingersoll & Rooney PC

20080280305 - Assays for detecting hiv-1 tat protein in hiv-1 infection: A method for detecting or measuring HIV-1 Transactivating (Tat) protein in a biological sample comprising contacting the biological sample with an amount of a basic protein effective to reduce interference with binding between anti-HIV-1 Tat Epitope 2 ligand and Tat that is caused by acidic components within the sample or... Agent: Howson And Howson

20080280307 - Chimeric recombinant antigens of toxoplasma gondii: The invention described herein relates to a method for combining antigen fragments of Toxoplasma gondii proteins, in the form of chimeric fusion products, and their use as diagnostic and immunogenic agents.... Agent: Steinfl & Bruno

20080280308 - G protein coupled receptor signaling modulation: This invention relates to methods for identifying peptides and other compounds which block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which stabilize a particular conformer of a G protein coupled receptor. Assays, methods of treatment and other methods developed in conjunction with these... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080280306 - Immunoassay for determining the release of neurotensin into the circulation: The invention relates to an immunodiagnostic method for determining the release of neurotensin into the circulation of mammals based on the selective determination of an immunoreactivity of the N-terminal portion of a mammal proneurotensin (PNT immunoreactivity) m a serum or plasma sample of a mammal; this immunoreactivity is not neurotensin... Agent: Heslin Rothenberg Farley & Mesiti PC

20080280309 - Monoclonal antibodies and uses thereof: The technology relates to monoclonal antibodies useful in the identification of cancer cells. In one embodiment, mAbs with specificity for tumor antigens are provided. In one embodiment, methods for treating cancer using mAbs are provided. In another embodiment, methods for detecting cancerous cells are provided. In another embodiment, kits for... Agent: Patrick J. Halloran, Ph.d., J.d

20080280310 - Testing for blood group immunological reaction without the use of anti-human globulin: A method testing for blood antigens (known as forward blood grouping) is presented wherein known antibodies are attached to a solid surface and the red blood cell sample for immunological reaction is centrifuged to physically overcome the natural repellent force between two red cells (know in the industry as the... Agent: Louis Panagopoulos

20080280311 - Immunoassay for the simultaneous immunochemical determination of an analyte (antigen) and a treatment antibody targeting the analyte in samples (recovery immunoassay): The invention relates to an immunoassay for the simultaneous immunochemical determination of an analyte (antigen) and a treatment antibody targeting the analyte in samples (recovery immunoassay). The inventive immunoassay comprises an optionally marked catcher antibody bound to a surface, a marked treatment antibody, or a marked antibody which has the... Agent: Buchanan Ingersoll & Rooney PC

20080280312 - Mutant glucose dehydrogenase: Substrate specificity for glucose of a glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 13 is improved by substituting another amino acid residue for the amino acid residue at position 472 and/or 475.... Agent: Knobbe Martens Olson & Bear LLP

20080280313 - Coccidian parasite casein kinase i as a chemotherapeutic target for antiprotozoal agents: Isolated nucleic acid molecules encoding coccidian casein kinase I, CKI, enzymes from the species Eimeria tenella and Toxoplasma gondii are disclosed. The isolation of these coccidian CKI cDNA sequences results in the disclosure of purified forms of E. tenella and T. gondii CKI proteins, recombinant vectors and recombinant hosts which... Agent: Merck And Co., Inc

20080280314 - Devices and methods for profiling enzyme substrates: The present invention relates to apparatus and methods for separating and detecting enzyme substrates using separation gels. For example, the apparatus and methods can be used to separate and detect kinase substrates for further analysis. The apparatus and methods can also be used to detect enzyme inhibitors, such as kinase... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080280315 - Swatch for testing the washing performance of an enzyme: The present invention relates to a swatch comprising a pH-indicator substance and a substrate for an enzyme for testing the washing performance of the enzyme, e.g. an enzyme for use in detergent compositions.... Agent: Novozymes North America, Inc.

20080280317 - Comprehensive characterization of complex proteins at trace levels: A combination of “bottom up” and “top down” MS analysis of posttranslational modifications in complex proteins is described. The method comprises digestion of the protein with an enzyme that forms larger peptide fragments than trypsin (>3000 D), performing HPLC with the fragments and applying a new data acquisition strategy using... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20080280316 - Method of detection, separation and identification for expressed trace protein/peptide: A method of detection separation and identification for expressed trace protein/peptide; and a system therefor. There is provided a method of detecting, separating and identifying a minute amount of expressed protein and/or peptide, characterized in that a fluorescent derivative of protein and/or peptide contained in a test subject sample having... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080280320 - Formulation of antigen: The present invention regards methods and formulations for diagnosis, prevention and treatment of disease. More particularly, the present invention teaches methods and formulations for diagnosis, prevention and treatment with antigen in autoimmune disease, allergy, rejection of transplants and cancer. Examples illustrate how the methods of formulations of the invention may... Agent: Roger A. Gilcrest

20080280319 - Gsh adducts and uses thereof: This invention relates to biomarkers of oxidative stress and their use. Specifically, the invention relates to thiadiazabicyclo-4-oxo-2(E)-nonenal-Glutathione adduct as a novel biomarker of oxidative stress and its diagnostic use.... Agent: Pearl Cohen Zedek Latzer, LLP

20080280318 - Isolation and culture of a high purity population of cone photoreceptor cells by tissue dissociation and pna-panning, and biological applications thereof: The present invention provides a process and kit for isolating cone photoreceptor cells from retinal tissue with a purity level of at least 80%, typically of about 90%. The isolation process uses a PNA-panning procedure conducted on dissociated retinal tissue. The present invention also provides a culture medium enabling the... Agent: Marshall, Gerstein & Borun LLP

20080280324 - Glycoengineering in mushrooms: The invention relates to the field of genetic engineering, more specifically to the field of production of glycoproteins, more specifically to the engineering of the glycosylation pattern of glycoproteins. Provided is a method for producing a glycoprotein in a recombinant host cell, comprising allowing expression of said glycoprotein in a... Agent: Hoffmann & Baron, LLP

20080280323 - Method for producing epidermal growth factor using fusion proteins comprising fas-1 domain: The present invention provides a fusion protein in which a polypeptide comprising Fas-1 domain is fused in frame to N-terminal or C-terminal of human EGF, a nucleotide sequence encoding the fusion protein, an expression vector containing the nucleotide sequence, a transformant transformed by the nucleotide sequence and a method for... Agent: Harness, Dickey & Pierce, P.L.C

20080280326 - Novel gonadotropin-releasing hormone, precursor peptides thereof and genes encoding the same: e

20080280325 - Polypeptides having endoglucanase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes North America, Inc.

20080280327 - Novel p-selectin ligand protein: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the... Agent: Wyeth/finnegan Henderson, LLP

20080280328 - Glucoamylase variants: The present invention relates to glucoamylase variants with improved properties and methods of utilizing the glucoamylase variants.... Agent: Novozymes North America, Inc.

20080280329 - Enzymatic synthesis of deoxyribonucleosides: The present invention relates to a method for the in vitro synthesis of deoxyribonucleosides and enzymes suitable for this method.... Agent: Fulbright & Jaworski, LLP

20080280330 - Cover for sample with sample-size independent height adjustment: The present invention relates to a device and a method for controlling the temperature of at least one sample. The device comprises at least the following means: (a) means for accommodating at least one sample; (b) means for heating and/or cooling at least one sample; (c) means for covering at... Agent: King Spalding LLP

20080280331 - Microfluidic analysis system: A thermal cycling device (3) device a number of fixed thermal zones (11, 12, 13) and a fixed conduit (10) passing through the thermal zones. A controller maintains each thermal zone including its section of conduit (10) at a constant temperature. A series of droplets flows through the conduit (10)... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080280322 - Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity: The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to glycosylation engineering to generate proteins with improved therapeutic properties, including antibodies with increased antibody-dependent cellular cytotoxicity.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080280321 - Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof: The present invetion relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also realtes to an isolated nucleic acid encoding the leafhopper ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene eypression in an ecdysone receptor-based gene expression modulation... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080280332 - Production of resistant starch product having tailored degree of polymerization: A process for producing a starch comprises treating a feed starch that comprises amylopectin with glucanotransferase to produce a chain-extended starch, treating the chain-extended starch with a debranching enzyme to produce a starch product that comprises amylose fragments, crystallizing at least part of the starch product, heating the starch product... Agent: Williams, Morgan & Amerson, P.C.

20080280333 - Use of the repressor glxr for the synthesis of lysine in corynebacterium glutamicum: Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080280334 - Method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds: A process is disclosed for preparing (3R,4R)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (I), or (3S,4S)-3-hydroxy-4-hydroxymethylpyrrolidine, the compound of formula (Ia) involving, as a key step, the enzyme-catalysed enantioselective hydrolysis of a racemic 3,4-trans-disubstituted pyrrolidinone compound of formula (II).... Agent: Amster, Rothstein & Ebenstein LLP

20080280335 - Manufacturing method of kaempferol: Disclosed is a kaempferol preparing method comprising isolating kaempferol from kaempferol glucosides using an acid, a base, an enzyme or a microbe producing the enzyme. More specifically, the method comprises obtaining a plant extract containing kaempferol glycosides from a plant using water or an organic solvent; and hydrolyzing the plant... Agent: Merchant & Gould PC

20080280336 - Process for the preparation of dihydroxy esters and derivatives thereof: wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy... Agent: Morgan Lewis & Bockius LLP

20080280337 - Process for the production of citronellal: The invention relates to a process for the production of optically active Citronellal by enzymatic reduction of Citral with a reductase from Zymomonas mobilis.... Agent: Connolly Bove Lodge & Hutz, LLP

20080280338 - Biofuel processing system: According to one embodiment, a biofuel processing system includes a biomass conversion system, a gasification reactor and/or a pyrolysis reactor, and a synthetic fuel creation system. The biomass conversion system uses a biological process to create a low-molecular-weight hydrocarbon stream from a biomass. The reactor generates heat and hydrogen using... Agent: Baker Botts L.L.P.

20080280339 - Cell training for local field stimulation: A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080280340 - Method and apparatus for bacterial transformation by electroporation with waveforms incorporating pulsed rf between 3 and 125 mhz: A method and apparatus for electroporation includes placing a mixture of bacterial suspension and transforming DNA into an electroporation cuvette. The resulting sample is subjected through a current-limiting device to a complex 5 waveform including a burst of high-voltage radio-frequency current, which in some embodiments is superimposed on a biphasic... Agent: Lathrop & Gage Lc

20080280341 - System and method for local field stimulation: A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080280342 - Molecular communication system: There is provided a molecular communication system capable of transmitting an information molecule in which predetermined information is encoded to a target destination under good controllability. The molecular communication system includes a molecular transmitter for transmitting the information molecule with prescribed information encoded, a molecular receiver for receiving the information... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080280343 - Thrombin purification: The invention relates to thrombin compositions with reduced levels of high molecular weight impurities. In particular, the levels of factor Va, prions and/or viral agents are greatly reduced. This invention also relates generally to methods for the preparation of thrombin having a high degree of purity and high specific activity.... Agent: King Pharmaceuticals, Inc.

20080280345 - Screening method: The present invention relates to a method for screening for variant peptides using mass spectrometry (MS). The present invention also relates to a system and a kit for performing the method.... Agent: Banner & Witcoff, Ltd.

20080280344 - Subtilase variants having altered immunogenictiy: The present invention relates to subtilase subtilases with an altered immunogenicity, particularly subtilases with a reduced allergenicity. Furthermore, the invention relates to expression of said subtilase variants and subtilases and to their use, such as in detergents and oral care products.... Agent: Novozymes North America, Inc.

20080280346 - System for the production of dimeric proteins based on the transport system of hemolysin of escherichia coli: The system comprises a DNA construct comprising: a) a first nucleic acid sequence containing the nucleotide sequence coding for a product of interest; b) a second nucleic acid sequence containing the nucleotide sequence coding for a dimerization domain; and c) a third nucleic acid sequence containing the nucleotide sequence coding... Agent: Moore & Van Allen PLLC

20080280347 - Method for manufacture of sanitised organic sludge: It is described a method for manufacture of sanitised organic sludge, said method comprising the following steps: mechanical mixing of a cellulose containing component, a super absorbent and dewatered organic sludge; leading the mixture to a sanitising container; continuously supplying air to the sludge mixture until the desired temperature has... Agent: Brooks Kushman P.C.

20080280348 - Method for converting aloeresin a to aloesin: The invention provides a process for hydrolytically converting aloeresin A to aloesin by the following reaction: The amount of aloesin available for extraction from sap of aloe plants is thereby increased and the extraction and purification of the aloesin is also made easier and less costly. As aloesin is more... Agent: Marshall, Gerstein & Borun LLP

20080280350 - Real-time pcr system: A real-time PCR system for detecting gene expression levels includes plural reaction regions, a like plural number of heating portions arranged corresponding to the reaction regions and having heat sources, respectively, an optical unit capable of irradiating exciting light of a specific wavelength to all of the plural reaction regions,... Agent: Bell, Boyd & Lloyd, LLP

20080280349 - Temperature control device: The present invention has an object to selectively culture either one of mold and yeast, both of which are fungi, with priority. In order to attaint the object, a cell parts group 101 is heated by a heating mechanism 102 and cooled by a cooling mechanism 103. These operations are... Agent: GlobalIPCounselors, LLP

20080280351 - Method and apparatus for preparing cells for microtome sectioning and archiving nucleic acids and proteins: A method and apparatus for embedding cells that utilizes a flow-through embedding technique maximizes the efficiency of extractions and decreases time for embedding the cell fragments, minimizes cell loss, and automatically positions cell samples at the position in which a microtome blade will section them. The apparatus includes a cell... Agent: Wolf Greenfield & Sacks, P.C.

20080280352 - Method and equipment for cultivating anaerobic ammonium-oxidizing bacteria: The present invention can feed substrates without waste to generate seed sludge with high bacterial cell concentrations and can start up operation within a short time, in cultivating anaerobic ammonium oxidizing bacteria with ammonium and nitrite as substrates. Equipment for cultivating anaerobic ammonium-oxidizing bacteria, which cultivates, in a cultivation tank,... Agent: Oliff & Berridge, PLC

20080280353 - Hybrid nucleic acid assembly: A detection device comprised of a hybrid nucleic acid assembly. The device further comprises a nucleic acid polymer, a first nanoparticle conjugated to the nucleic acid polymer, a second nanoparticle conjugated with the nucleic acid polymer, a means for introducing energy into the first nanoparticle, means for detecting energy from... Agent: Buchanan, Ingersoll & Rooney PC

20080280356 - Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site: Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective protein or polypeptide coding sequence. The vector constructs include the coding... Agent: Ropes & Gray LLP

20080280355 - Control of gene expression with the use of a transcription attenuator: This invention relates to a system for the expression of heterologous genes, comprising an attenuator element which inhibits the elongation of the transcription of the heterologous genes, the expression of which is to be controlled, and two regulating modules which control the expression of the attenuator element. The invention also... Agent: Arent Fox LLP

20080280354 - Recombinant poxvirus for chimeric proteins of the human immunodeficiency virus: The invention relates to HIV chimeric gene formed by the union of fragments of different genes of said virus, wherein said fragments contains epitopes for cytotoxic T cells (CTL) or HIV-1 auxiliary T cells, which are presented by a wide range of antigens of type Major Histocompatibility Complex (HLA-I). Recombinant... Agent: Hoffmann & Baron, LLP

20080280357 - Cryopreservation of hepatocytes: The invention relates to processes for the preparation of liver cells for cryopreservation, processes for cryopreservation of isolated liver cells and processes for the preparation of a culture of cryopreserved isolated liver cells.... Agent: Ostrolenk Faber Gerb & Soffen

20080280359 - Oligoribonucleotide inhibiting growth of tumor cells and method therefor: A cytostatic agent for bile duct carcinoma and others containing an oligoribonucleotide comprising a segment of bases identical or complementary to less than 30 consecutive bases of nucleotide sequence of SEQ ID NO: 1, which includes at least 19 consecutive nucleotides of bases 403-423, 507-527 or 989-1009 of SEQ ID... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20080280358 - Synthetic peptides that cause f-actin bundling and block actin depolymerization: Synthetic peptides derived from sucrose synthase, and having homology to actin and actin-related proteins, sharing a common motif, useful for causing acting bundling and preventing actin depolymerization. Peptides exhibiting the common motif are described, as well as specific synthetic peptides which caused bundled actin and inhibit actin depolymerization. These peptides... Agent: Lawrence Berkeley National Laboratory

20080280360 - Method for producing biomaterial scaffolds: The present invention provides a multilayer scaffold for tissue engineering. The scaffold comprises at least a first layer comprised of a polymer having a pattern of microchannels therein; and at least a second layer comprised of a polymer having a pattern of microchannels therein. The first and second layers are... Agent: David S. Resnick

20080280361 - Preparation and use of plant embryo explants for transformation: The present invention relates to excision of explant material comprising meristematic tissue from seeds, and storage of such material prior to subsequent use in plant tissue culture and genetic transformation. Methods for tissue preparation, storage, and transformation are disclosed, as is transformable meristem tissue produced by such methods, and apparati... Agent: Sonnenschein Nath & Rosenthal LLP

20080280362 - Methods for reprogramming somatic cells: The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated... Agent: Ropes & Gray LLP

20080280363 - Pseudotyped baculovirus and its use: A viral G protein-pseudotyped baculovirus, in which the G protein is truncated and comprises the ectodomain, transmembrane domain and cytoplasmic tail domain. Such a baculovirus can be used for transduction of cells and for gene therapy.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080274446 - Cryopreserved human neuronal cultures: Cryopreserved cultures of post-mitotic neuronal or neural-like cells are provided having a viability after thaw of greater than 10%, typically greater than 50%. Once thawed, the cells are capable of further differentiation. In one embodiment, less than 20% of the cryopreserved cells are self-proliferating cells. The cells can be provided... Agent: Coleman Sudol Sapone, P.C.

20080274447 - Method and apparatus for implementing threshold based correction functions for biosensors: A biosensor system, method and apparatus are provided for implementing threshold based correction functions for biosensors. A primary measurement of an analyte value is obtained. A secondary measurement of a secondary effect is obtained and is compared with a threshold value. A correction function is identified responsive to the compared... Agent: Nixon Peabody LLP

20080274448 - Method for detecting a hydrophobic region of a target substance: An object of the present invention is to provides a method for detecting a hydrophobic region of a target substance that is capable of forming a hydrophobic region, such as a protein, which can detect a fluorescent analyte with high sensitivity with the use of a simple detection apparatus. The... Agent: Sughrue Mion, PLLC

20080274449 - Assay for detection of human parvovirus b19 nucleic acid: Nucleic acid oligomers specific for human parvovirus B19 genomic DNA are disclosed. An assay for amplifying and detecting human parvovirus B19 nucleic acid in biological specimens is disclosed. Compositions for detecting the presence of parvovirus B19 genomic DNA in human biological specimens are disclosed.... Agent: Gen Probe Incorporated

20080274451 - Body for flow-through cells and the use thereof: A system of flow-through cells is obtained by assembling a body with a base plate. The body has a first spring element and a first stop, disposed on opposite end sections of the body, at least one second spring element and a corresponding second stop, disposed on opposite faces of... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080274450 - Methods and applications of molecular beacon imaging for identifying and validating genomic targets, and for drug screening: A method for characterizing the gene expressions of a sample of cells of a living subject, where the sample of cells is characterized by one or more marker sequences. In one embodiment, the method includes the steps of providing one or more types of molecular beacons, each type of molecular... Agent: Morris Manning Martin LLP

20080274469 - C-kit oncogene mutations in melanoma: The present invention provides methods of detecting c-KIT-dependent-melanoma for diagnostic and prognostic purposes. The invention further provides methods of treating such melanoma by inhibiting c-KIT.... Agent: Townsend And Townsend And Crew, LLP

20080274460 - Common allele on chromosome 9 associated with coronary heart disease: Disclosed are methods and compositions for determining whether a person carries an allele associated with increased risk for coronary atherosclerosis by determining whether the person has had RA-CHR9 allel, such as by determining whether the person has an RA-CHR9 allele-associated single nucleotide polymorphism (SNP).... Agent: Richard Aron Osman

20080274453 - Diagnostics and therapeutics for macular degeneration: The invention relates to diagnostics and therapeutics and animal models for macular degeneration, specifically as they relate to the association described herein between macular degeneration and arterial wall disruptive disorders. In one embodiment, the invention provides kits and methods for diagnosing macular degeneration comprising identifying a marker for an arterial... Agent: Townsend And Townsend And Crew, LLP

20080274466 - Enrichment through heteroduplexed molecules: The present invention relates to the enrichment of specific target sequences Enrichment can be achieved through the formation of a heteroduplex that includes the specific target sequence and then the specific cleavage of the heteroduplex. A binding moiety is then added to the cleaved heteroduplex, allowing for the subsequent manipulation... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080274464 - Gene detecting method: Disclosed is a gene detecting method for determining mutation of a specific base or presence/absence of a specific base in a target gene. There are provided a the target gene sample and a control gene sample having a base sequence which is wild-type or standard-type with respect to the target... Agent: Fay Sharpe LLP

20080274465 - Method for breast cancer diagnosis/prognosis: s

20080274459 - Method for collecting and storing biological materials: A method for collecting and storing biological material includes the steps of obtaining a patient identity of a patient and a biological material from a patient. A DNA identity analysis is performed to establish a DNA identity for the patient. The DNA identity is associated with the patient identity and... Agent: Akerman Senterfitt

20080274463 - Method for quantifying biomolecules conjugated to a nanoparticle: Disclosed embodiments concern quantifying a biomolecule conjugated to a nanoparticle. Quantifying typically comprises determining the number of biomolecules per nanoparticle. Any suitable biomolecule can be used, including but not limited to, amino acids, peptides, proteins, haptens, nucleic acids, oligonucleotides, DNA, RNA, and combinations thereof. A single type of biomolecule may... Agent: Klarquist Sparkman, LLP

20080274456 - Methods and compositions for modifying gene regulation and dna damage in ageing: The invention relates to gene regulation in ageing, and age-related cognitive decline. The invention, in particular relates to methods for screening a subject for a propensity to develop diseases associated with oxidative stress, and for age-related conditions, by examining the up-regulation and/or down-regulation of at least one gene associated within... Agent: Nutter Mcclennen & Fish LLP

20080274471 - Methods for detecting an increased risk for coronary heart disease: The invention relates generally to an allele on human chromosome 9 associated with increased risk for coronary heart disease and the use or detection of such an allele in determining whether a human has an increased risk for coronary heart disease. In one aspect, the invention relates to methods for... Agent: Perlegen Sciences, Inc. Legal Department

20080274457 - Methods for differentiating malignant from benign thyroid tissue: Methods of identifying malignant thyroid tissue comprising testing a thyroid tissue sample for the expression of at least two genes chosen from CCND2, PCSK2, and PLAB. Kits for use in the disclosed methods are also provided.... Agent: Calfee Halter & Griswold, LLP

20080274470 - Non-invasive detection of endometrial cancer: The present invention provides a non-invasive method of obtaining a sample of endometrial cells for use in the diagnosis of endometrial cancer, as well as methods and kits for diagnosing, determining the prognosis of, and monitoring endometrial cancer.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080274472 - Novel kinases and uses thereof: Novel kinase polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length kinase proteins, the invention further provides isolated kinase fusion proteins, antigenic peptides, and anti-kinase antibodies. The invention also provides kinase nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host... Agent: Millennium Pharmaceuticals, Inc.

20080274468 - Novel means for the diagnosis and therapy of ctcl: The invention relates to a novel molecule, termed SC5 by the inventors, to a novel allelic form of p140, and to the biological applications of SC5 and p140 molecules, notably in the diagnosis and therapy of CTCL.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080274467 - Novel therapeutic targets in cancer: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20080274458 - Nucleic acid quantitation methods: The invention relates to a method of determining the amount of a target nucleic acid sequence in a sample, the method comprising: obtaining multiple distinguishable amplicons of the target nucleic acid sequence, each comprising a distinguishing tag and a target portion; amplifying the amplicons in a single reaction volume; and... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080274461 - Perinucleolar compartment markers for cancer: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.... Agent: Casimir Jones, S.c.

20080274452 - Process for large scale production of plasmid dna by e.coli fermentation: The present invention relates generally to a method for increasing the yield of plasmid DNA production. The method includes the steps of selecting a highly productive clonal subtype of a strain of E. coli, including but not limited to the DH5 strain, harboring a DNA plasmid and cultivating said clonal... Agent: Merck And Co., Inc

20080274454 - Reversible and chemically programmable micelle assembly with dna block-copolymer amphiphiles: The present invention is directed to amphiphilic block copolymers. More particularly the present invention is directed to amphiphilic block copolymers comprising a polynucleotide block and a hydrophobic polymer block, to micelles formed from the block copolymers, and to methods of using the micelles.... Agent: Marshall, Gerstein & Borun LLP

20080274462 - Universal bases for nucleic acid analyses, methods for using universal bases, and kits comprising universal bases: Compounds, methods and kits for making and analyzing primer extension products incorporating one or more universal bases are described, including methods and kits for nucleic acid sequencing and microsatellite analysis.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080274455 - Use of genes as molecular markers in diagnosis of schizophrenia and diagnostic kit for the same: m

20080274473 - Amyloid binding assays: Provided herein are amyloid-binding assays that simulate in situ brain conditions by combining binders with various A-beta species on mammalian brain tissue. In general the amyloid-binding assays comprise the steps of (a) contacting a mammalian brain tissue sample with at least one A-beta species; (b) applying a putative binder to... Agent: General Electric Company Global Research

20080274474 - Authentication method and system for authenticating security documents, security document and security element: An authentication system for authenticating security documents contains at least an enzyme and a substrate and any co-enzymes and/or co-factors needed, capable of an enzymatic conversion. This conversion leads to a detectable change. The security-document contains at least one of the enzyme and the substrate. According to the invention the... Agent: Hoffmann & Baron, LLP

20080274475 - Hla-e binding: The invention relates to a method of testing a compound for biological activity, which method comprises providing cells expressing one of the CD94/NKG2 family of receptors, contacting the cells with recombinant HLA-E under binding conditions in the presence of the test compound, and determining whether the presence of the compound... Agent: Volpe And Koenig, P.C.

20080274480 - Botulinum toxin type a immunoresistant assay: The present specification discloses methods for determining Botulinum Toxin Type A immunoresistance in a mammal by detecting the amount of BoNT/A toxin-BoNT/A receptor complexes or the amount of free BoNT/A present or absent in a sample.... Agent: Allergan, Inc.

20080274481 - Methods for diagnosing ovarian cancer: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition.... Agent: Edwards Angell Palmer & Dodge LLP

20080274476 - Assay method: There is disclosed a method for determining the activity of gamma-secretase in a text subject, using a biological sample from the subject.... Agent: Merck And Co., Inc

20080274477 - Forms of factor xiia: A 53 Kd novel form of factor XIIa and related products, including nucleic acid molecules, monoclonal and polyclonal antibodies and hybridoma cell lines. Also assays for a 53 Kd form of factor XIIa and uses of said assays in diagnostic and prognostic methods, for example in the prediction of survival... Agent: Leon R Yankwich Yankwich & Associates

20080274478 - Novel aromatic prenyltransferases, nucleic acids encoding same and uses therefor: In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation of a C—C bond between a prenyl group and a compound containing an aromatic nucleus, and also... Agent: Foley & Lardner LLP

20080274479 - Assay of ubiquitinization of synoviolin and use thereof in screening: The present invention relates to an assay method for determining a auto-ubiquitination activity of synoviolin, comprising reacting synoviolin and ubiquitin in a reaction system containing them and determining an amount of ubiquitin binding to synoviolin, to a method of screening a substance capable of regulating such an activity, and to... Agent: Dickstein Shapiro LLP

20080274482 - Beta 1 integrin activation as a marker for asthma: Methods are provided in which β1 integrin activation on eosinophils is detected. In a first version of the method, a sample including the eosinophils is obtained from a subject. In one embodiment, the sample is whole blood. An amount of activation of β1 integrin in the eosinophils is detected. The... Agent: Whyte Hirschboeck Dudek S.c.

20080274483 - Method for diagnosing renal disorder, hemolytic uremic syndrome and enterohemorrhagic infectious disease caused by escherichia coli: Methods for diagnosing renal disorder, hemolytic uremic syndrome and enterohemorrhagic E. coli infectious disease at an early stage, and for diagnosing the severity of these diseases are provided. Detection of excretion of AQP2 and/or molecules derived therefrom into urine of a subject, or determination of the amount of excretion of... Agent: Marshall, Gerstein & Borun LLP

20080274484 - Method for diagnosing renal disorder, hemolytic uremic syndrome and enterohemorrhagic infectious disease caused by escherichia coli: Methods for diagnosing renal disorder, hemolytic uremic syndrome and enterohemorrhagic E. coli infectious disease at an early stage, and for diagnosing the severity of these diseases are provided. Detection of excretion of AQP2 and/or molecules derived therefrom into urine of a subject, or determination of the amount of excretion of... Agent: Marshall, Gerstein & Borun LLP

20080274485 - Enhancing a luminescent signal: Methods and compositions are described for assaying luciferase bioluminescence in vitro and in vivo cells. The compositions provide at least one of enhanced stability of signal or magnitude of signal by varying the composition of the buffer. One or more of the following parameters have been varied: the presence or... Agent: Harriet M. Strimpel, D. Phil.

20080274486 - Method of assaying fad synthetase: The present invention relates to methods of determining activity of flavin adenine dinucleotide (FAD) synthetase, and methods of identifying compounds that modulate the activity of this enzyme.... Agent: Astrazeneca R&d Boston

20080274487 - Use of serum/glucocorticoid-regulated kinase: The invention relates to the use of an SGK protein, a functional derivative or fragment thereof, or a nucleic acid coding for one such protein, fragment or derivative, in order to discover active ingredients for the prevention or treatment of degenerative cartilage changes.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080274488 - Covalent tethering of functional groups to proteins and substrates therefor: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20080274489 - Methods for detecting organisms and enzymatic reactions using raman spectroscopy: The present disclosure provides systems for the rapid and sensitive detection of organisms and molecules in samples. Reactants that produce Raman-active products are used in combination with Raman light scattering. The present disclosure can also be used to measure enzyme-kinetics.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080274493 - Apparatus and methods for conducting assays and high throughput screening: The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of... Agent: Townsend And Townsend And Crew, LLP

20080274492 - Detection of platinum group metals with fluorophores via allylic oxidative insertion: A method of detecting platinum group metals in a sample is provided. The method comprises the step of contacting the sample with a fluorophore capable of undergoing allylic ether or allylic ester cleavage. The fluorophore has an oxygen-protected moiety, the protecting group having an allylic functionality. A reducing agent and... Agent: Meyer Unkovic & Scott LLP

20080274494 - Method and apparatus for co2 sequestration: A method and apparatus for growing algae for sequestering carbon dioxide and then harvesting the algae includes a container for a suspension of algae in a liquid and a bioreactor having a translucent channel in fluid communication with the container to absorb CO2 and grow the algae. A monitor determines... Agent: Conley Rose, P.C. David A. Rose

20080274491 - Modulation of the integrin linked kinase signaling pathway to promote cardiac cell proliferation and self-renewal: Modulation of the integrin-linked kinase (ILK) signaling pathway is used to enhance the remodeling process relevant to a wide range of cardiac diseases. More specifically, a process to instigate beneficial human cardiac hypertrophy or for post myocardial infarction (MI) remodeling comprising illiciting an overexpression of ILK, is described. The ILK... Agent: Mchale & Slavin, P.A.

20080274490 - Pd-1, a receptor for b7-4, and uses therefor: Disclosed is a method for modulating an immune response by modulating signaling via PD-1. The immune response may be downregulated by increasing signaling via PD-1, or may be upregulated by decreasing signaling via PD-1. Agents which are useful for stimulating signaling via PD-1 to downregulate an immune response include an... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20080274495 - Diagnostic method for testing hydration and other conditions: Methods for the non-invasive collection of a liquid sample in small quantities, such as urine for testing hydration in infants and incontinent adults, directly at the source of that sample, isolation of the collected sample from a testing site, the transportation of that sample to a site for testing contained... Agent: Townsend And Townsend And Crew, LLP

20080274496 - Methods, reagents and instrumentation for preparing impregnated tissue samples suitable for histopathological and molecular studies: A process and kit for the production of paraffin sections of biological tissue, especially for molecular pathology studies, is described. In the process, the tissue sample is simultaneously fixed, dehydrated and cleared in a first step, subsequently dehydrated and cleared in a second step and infiltrated with an inert specimen... Agent: Knobbe Martens Olson & Bear LLP

20080274502 - Bacillus thuringiensis cryet33 and cryet34 compositions and uses therefor: Disclosed are Bacillus thuringiensis strains comprising novel crystal proteins which exhibit insecticidal activity against coleopteran insects including red flour beetle larvae (Tribolium castaneum) and Japanese beetle larvae (Popillia japonica). Also disclosed are novel B. thuringiensis crystal toxin genes, designated cryET33 and cryET34, which encode the colepteran-toxic crystal proteins, CryET33 (29-kDa)... Agent: Howrey LLP

20080274501 - Method of purifying acidic proteins expressed in plants: The present invention provides a rapid and relatively simple process for purification of acidic proteins expressed in tobacco cells. The process comprises three main purification steps: precipitation with polyethyleneimine, column chromatography with a hydrophobic interaction resin, and column chromatography with hydroxyapatite. The process provides pure or essentially pure protein at... Agent: Latimer, Mayberry & MatthewsIPLaw, LLP

20080274498 - Methods for producing modified glycoproteins: Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower... Agent: Merck And Co., Inc

20080274503 - Modified shine-dalgarno sequences and methods of use thereof: Novel Shine-Dalgarno (ribosome binding site) sequences, vectors containing such sequences, and host cells transformed with these vectors are provided. Methods of use of such sequences, vectors, and host cells for the efficient production of proteins and fragments thereof in prokaryotic systems are also provided. In particular embodiments of the invention,... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20080274505 - Polynucleotide encoding a novel trp channel family member, ltrpc3, and splice variants thereof: The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides.... Agent: Louis J. Wille Bristol-myers Squibb Company

20080274499 - Polypeptides having alpha-glucosidase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes, Inc.

20080274500 - Promoter variants for expressing genes in a fungal cell: The present invention relates to methods for producing a biological substance, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the biological substance, wherein the fungal host cell comprises a first nucleic acid sequence encoding the biological substance operably linked to a second nucleic... Agent: Novozymes, Inc.

20080274497 - Recombinant protein production in a human cell: Methods and compositions for the production of recombinant proteins in a eukaryotic cell line are disclosed. The methods and compositions are particularly useful for generating stable expression of recombinant proteins of interest that are modified post-translationally, for example, by glycosylation. Such proteins may have advantageous properties in comparison with their... Agent: Trask Britt

20080274504 - Soluble erbb3 receptor isoforms: The present invention discloses a method using human soluble ErbB3, for example p85-sErbB3, as a negative regulator of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present invention also discloses p85-sErbB3 binding to heregulin with an affinity comparable to that of full-length ErbB3, and competitively inhibiting high affinity heregulin binding to... Agent: Cohen & Grigsby, P.C.

20080274506 - Polypeptide variants with altered effector function: The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function as a consequence of one or more amino acid modifications in the Fc region thereof.... Agent: Genentech, Inc.

20080274508 - Expression system for enhancing solubility and immunogeneicity of recombinant proteins: Expression system for enhancing solubility and immunogenicity of recombinant proteins. The expression system includes a protein expression vector that contains a chimeric gene encoding a chimeric protein. The chimeric protein contains three polypeptidyl fragments: (a) a first polypeptidyl fragment at the N-terminal end of the chimeric protein that contains a... Agent: Ipc Intellectual Property Connections, Inc.

20080274507 - Methods of protein production using anti-senescence compounds: Methods of producing a protein in cell culture comprising an anti-senescence compound, such as the antioxidant carnosine, are provided. According to teachings of the present invention, cells grown in a cell culture medium comprising an anti-senescence compound exhibit increased viability and productivity. Furthermore, cell cultures grown in the presence of... Agent: Choate, Hall & Stewart LLP/wyeth

20080274509 - Process for preparing sugar-containing hydrolyzates from lignocellulose: A sugar-containing hydrolyzate is produced from a lignocellulose-containing material by a) pretreating the lignocellulose-containing material with a chemical compound selected from sulphuric acid, alkali, peroxodisulphates, potassium peroxide, potassium hydroxide, and mixtures thereof, in the presence of water, thereby obtaining an aqueous phase, and b) after removing of the aqueous phase... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080274510 - Synthetic genes: The invention provides strategies, methods, vectors, reagents, and systems for production of synthetic genes, production of libraries of such genes, and manipulation and characterization of the genes and corresponding encoded polypeptides. In one aspect, the synthetic genes can encode polyketide synthase polypeptides and facilitate production of therapeutically or commercially important... Agent: Townsend And Townsend And Crew, LLP

20080274511 - Device for carrying out chemical or biological reactions: The invention relates to a device for carrying out of chemical or biological reactions with a reaction vessel receiving element for receiving a microtiter plate with several reaction vessels, wherein the reaction vessel receiving element has several recesses arranged in a regular pattern to receive the respective reaction vessels, a... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080274513 - Method and device for conducting biochemical or chemical reactions at multiple temperatures: Methods and devices for conducting chemical or biochemical reactions that require multiple reaction temperatures are described. The methods involve moving one or more reaction droplets or reaction volumes through various reaction zones having different temperatures on a microfluidics apparatus. The devices comprise a microfluidics apparatus comprising appropriate actuators capable of... Agent: Ward And Smith, P.A.

20080274514 - Penetrable cap having spaced-apart grooves: A cap having a plurality of spaced-apart grooves in a downwardly tapered inner wall of the cap to facilitate the formation of air passageways as the cap is penetrated by a pipette tip. The air passageways aid in venting air from a fluid-holding vessel closed with the cap.... Agent: Gen Probe Incorporated

20080274512 - Reagent transfer device: A device for transferring reagents in solid or liquid form from one place to another on an apparatus, said device comprising an upper portion, adapted to be held, and a lower portion adapted to hold reagents in solid or liquid form, in an available manner. For example, the reagents may... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20080274515 - Animal component free meningococcal polysaccharide fermentation and seedbank development: Animal-free meninge fermentation media and process is developed based upon use of a chemically defined medium. To improve polysaccharide production, fed-batch fermentation is examined using different feed solutions and feeding strategies. A feed solution containing glucose, amino acids, and trace metal elements produces Group A polysaccharide at approximately 3 times... Agent: Sanofi Pasteur, Inc.

20080274516 - Psod expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080274517 - Process for the manufacture of non-steroidal anti-inflammatory agents and intermediates thereof: e

20080274518 - Polypeptides and biosynthetic pathways for the production of monatin and its precursors: Methods and compositions that can be used to make monatin from glucose, tryptophan, indole-3-lactic acid, indole-3-pyruvate, and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid, are provided. Methods are also disclosed for producing the indole-3-pyruvate and 2-hydroxy 2-(indol-3-ylmethyl)-4-keto glutaric acid intermediates. Compositions provided include nucleic acid molecules, polypeptides, chemical structures, and cells. Methods include... Agent: Cargill, Incorporated

20080274519 - Flavonoid concentrates: t

20080274520 - Novel gene sms 37: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, PC

20080274521 - Delta-5 desaturases and their use in making polyunsaturated fatty acids: The present invention relates to Δ5 desaturases, which have the ability to convert dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) to arachidonic acid (ARA; 20:4 ω-6) and/or eicosatetraenoic acid (ETA; 20:4 ω-3) to eicosapentaenoic acid (EPA; 20:5 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturases along... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080274522 - Method for the production of 2-butanone: A method for the production of 2-butanone by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanone product.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080274523 - Production of isoprenoids: The present invention provides methods for a robust production of isoprenoids via one or more biosynthetic pathways. The invention also provides nucleic acids, enzymes, expression vectors, and genetically modified host cells for carrying out the subject methods. The invention also provides fermentation methods for high productivity of isoprenoids from genetically... Agent: Wilson Sonsini Goodrich & Rosati

20080274524 - Method for the production of 1-butanol: A method for the production of 1-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080274525 - Method for the production of 2-butanol: A method for the production of 2-butanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080274526 - Method for the production of isobutanol: A method for the production of isobutanol by fermentation using a microbial production host is disclosed. The method employs a reduction in temperature during the fermentation process that results in a more robust tolerance of the production host to the butanol product.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080274528 - Biofuel production methods and compositions: The invention provides methods for increasing the level of fermentable carbohydrates in a biofuel crop plant such as alfalfa or switchgrass, by modification of the lignin biosynthetic pathway. Also provided are plants prepared by the methods of the invention. Methods for processing plant tissue and for producing ethanol by utilizing... Agent: Sonnenschein Nath & Rosenthal LLP

20080274527 - Hydrolysis of arabinoxylan: The present invention relates to a process for enzymatic hydrolysis of arabinoxylan, and an enzyme composition suitable for use in such a process.... Agent: Novozymes North America, Inc.

20080274529 - Photoporation of cells: An opening is formed in a cell using laser radiation. A Bessel beam is formed using the laser radiation and the Bessel beam is directed onto the cell to form an opening. The guiding of material towards the opening may be involved using optical trapping/manipulation. The material may change cellular... Agent: Alston & Bird LLP

20080274530 - Peptide-forming enzyme gene: DNA and recombinant DNA that encode a peptide-forming enzyme, a method for producing a peptide-forming enzyme, and a method for producing a dipeptide are disclosed. A method for producing a dipeptide includes producing a dipeptide from a carboxy component and an amine component by using a culture of a microbe... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080274531 - Exo-specific amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof: This invention relates to amylase polypeptides, and nucleic acids encoding the polypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically the amylases of the current invention show an altered exospecifity.... Agent: Genencor International, Inc.

20080274532 - Blood coagulation accelerator and container for blood examination: The present invention provides a blood coagulation accelerator excellent under severe conditions at ordinary or higher temperatures and capable of exhibiting high blood coagulation performance stably over a long period of time, as well as a container for blood examination wherein the blood coagulation accelerator is accommodated. Disclosed is a... Agent: Sughrue Mion, PLLC

20080274533 - T4 bacteriophage bound to a substrate: T4 bacteriophages are bound to substrates such as liposomes using a binder.... Agent: Jagtiani + Guttag

20080274534 - Virus filtration of liquid factor vii compositions: The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).... Agent: Novo Nordisk, Inc. Intellectual Property Department

20080274535 - Hepatocyte bioreactor system for long term culture of functional hepatocyte spheroids: A rotating wall vessel is used as a culture vessel and bioreactor for the cultivation of hepatocytes in the form of spheroids to generate a culture with many properties of the intact liver. These properties include enzyme activity comparable to fresh cells and long-term maintenance of viability and cellular function... Agent: Loeb & Loeb, LLP

20080274536 - Culture double container and a method of culture: A culture double container 1 comprises a gas-permeable culture container 2 having an inlet and an outlet 6, a gas-impermeable container 3 covering the culture container 2, and joint portions 12 and 13 for holding the culture container 2 in the gas-impermeable container 3 in such a manner that space... Agent: Hedman & Costigan P.C.

20080274537 - Tool head for an apparatus for the automatic isolation and treatment of cell clones: The invention relates to a tool head for a device that is used to automatically isolate and treat cell clones by means of a cloning dome, which isolates the respective cell clone from the environment, said cloning dome being held in a detachable manner by the tip of a pipette... Agent: Bodner & O'rourke, LLP

20080274538 - Acoustic radiation for ejecting and monitoring pathogenic fluids: The invention relates to methods and devices that use focused radiation to handle and/or monitor pathogenic fluids. In particular, a method is provided for dispensing one or more droplets of a fluid containing a pathogen. The method involves providing the pathogen-containing fluid in a reservoir and applying focused radiation to... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20080274539 - Bioreactor for studying the effects of imposed stimuli on cellular activity: A bioreactor device for studying the effects of physical, chemical, mechanical and electromagnetic stimuli on the cellular activity. In particular, the device uses a sensorized premixing chamber (1), a culture chamber (2) for observing the development of the cells by a microscope (40). Output signals are transmitted to a control... Agent: Dennison, Schultz & Macdonald

20080274540 - Blood testing bottomed tube, stopper for blood testing bottomed tube and blood testing container: The present invention relates to a blood testing bottomed tube, which comprises a tubular member having an open one end and closed another end, and a coating layer formed on at least a part to be contacted with blood on said tubular member, said coating layer being made of a... Agent: Sughrue Mion, PLLC

20080274541 - Disposable bioreactor system: A cylindrical or annular polymeric bioreactor is disclosed which provides enhanced mixing and aeration of the growth medium while simultaneously offering reduced mechanical shear force.... Agent: Herbert Burkard

20080274542 - Polypeptide: Canine and feline 5T4 polypeptide sequences and nucleotide sequences encoding them are provided. A vector system comprising a nucleic acid encoding 5T4 and a 5T4-specific agent are also provided.... Agent: Marshall, Gerstein & Borun LLP

20080274543 - Neuronal cell propagation using rotating wall vessel: The present invention provides methods of propagating transformed neurons in a simulated microgravity environment generated by a rotating wall vessel (“3-D culture”) so that the phenotype of the transformed neurons so cultured becomes closer to that of non-transformed neurons (primary neurons) and less like the phenotype of transformed neurons cultured... Agent: Chester G. Moore Baker, Donelson, Bearman, Caldwell & Berkowitz, PC

20080274544 - Promotor for introducing extracellular substance into mammalian ovum and introduction method: The present invention provides a method, upon introducing an extracellular substance, such as sperm, a cell nucleus, a nucleic acid, and a protein, into a mammalian oocyte, for introducing the extracellular substance into a mammalian oocyte, which is safe for the mammalian oocyte, enables efficient introduction, and is technically easy.... Agent: Alston & Bird LLP

20080274545 - Bioreactor chamber apparatus, and method and system for fabricating and mechanically stimulating natural and engineered tissues: A bioreactor chamber assembly including a bioreactor chamber and an outer chamber assembly is provided. In one design, the bioreactor chamber includes an upper grip assembly having a plurality of struts extending downward terminating in upper grips, each strut terminating in an upper grip, and a lower grip assembly containing... Agent: Edwards Angell Palmer & Dodge LLP

20080274546 - Artificial physiological salt solution and manufacturing method for same: An artificial physiological salt solution, wherein the active hydrogen reaction value is 0.01 to 1, the pH is 4.0 to 7.9 and the osmotic pressure is 260 mOsm/L to 2560 mOsm/L, as well as a manufacturing method for the same are provided as a novel artificial physiological salt solution, which... Agent: Birch Stewart Kolasch & Birch

20080274547 - Use of nitric oxide modulators in agrobacterium-mediated plant transformation: Use of nitric oxide modulators during the transformation process can enhance Agrobacterium-mediated transformation of plants.... Agent: Sonnenschein Nath & Rosenthal LLP

20080274548 - Dopominergic neurons differentiated from embryonic cells for treating neurodegenerative diseases: Disclosed herein are methods for generating dopaminergic neurons in vitro by inhibiting a pathway component of a TGF-β signaling pathway and overexpressing one or more cell fate-inducing polypeptides in pluripotent cells, causing differentiation of the pluripotent cells into dopaminergic neurons. Also disclosed are methods for treating a neurodegenerative disease in... Agent: Foley & Lardner LLP

20080274549 - System and method for electroporating a sample: A system and method are described for electroporating a sample that utilizes one or more sets of electrodes that are spaced apart in order to hold a surface tension constrained sample between the electrodes. The first electrode is connected to the lower body of the system while the second electrode... Agent: Baker Botts L.L.P. Patent Department

20080274550 - Use of replicators to prevent gene silencing: Regulatory elements, specifically replicators and transgene constructs containing replicator nucleic acid sequences, are disclosed herein. Methods of using replicators and transgene constructs including replicators to inhibit, delay, or prevent gene silencing are also disclosed herein.... Agent: Klarquist Sparkman, LLP