Chemistry: molecular biology and microbiology inventions 10/08

20080261196 - Naphthalene diimide-zn(ii) complex having selectivity for pyrophosphate, preparation method thereof and detecting method of pyrophosphate using the same: The present invention provides a novel fluorescent chemosensor including a naphthalene diimide-Zn(II) complex, which can efficiently recognize pyrophosphate (PPi) at pH 7.4. The fluorescent chemosensor exhibits a new kind of excimer fluorescence, which is selective for PPi in 100% aqueous solution. Further, since the naphthalene diimide-Zn(II) complex of the present... Agent: Joseph Hyosuk Kim, Ph.d. Jhk Law

20080261203 - Detection of epstein-barr virus: The invention provides methods to detect EBV in biological samples using real-time PCR. Primers and probes for the detection of EBV are provided by the invention.... Agent: Fish & Richardson P.C.

20080261200 - Detection of nucleic acid mutations: A method for detecting a mutation in a target nucleic acid sequence in a sample, the target nucleic acid sequence comprising a first DNA strand and optionally the complementary strand thereof, said method comprising: (a) adding a detection primer to the nucleic acid, wherein the detection primer binds to the... Agent: Evan Law Group LLC

20080261198 - Diagnostic primers and method for detecting avian influenza virus subtype h5 and h5n1: The present invention provides primers directed to conserved regions of the HA and NA genes of avian influenza virus subtypes H5 or H5N1, and provides a method for detecting avian influenza subtype H5 or H5N1.... Agent: Klarquist Sparkman, LLP

20080261201 - Methods and compounds to alter virus infection: The invention provides a method to identify an agent that alters parvovirus transduction of mammalian cells. Also provided is a method to enhance transgene expression in a mammalian cell, as well as a method to identify an agent that alters NADPH oxidase activity in parvovirus transduced mammalian cells.... Agent: Schwegman, Lundberg & Woessner, P.A.

20080261197 - Nucleotide sequences of hiv-1 group (or subgroup) o retroviral antigens: An HIV-1 type (or subtype) O retrovirus protein, or a natural or synthetic polypeptide or peptide including at least a part of said protein, which is capable of being recognised by antibodies isolated from a serum resulting from infection by an HIV-1 type O VAU strain or an HIV-1 type... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080261199 - Rapid detection processes and related compositions: An improved detection method is described for an antigen such as a chemical compound, a peptide, or a nucleic acid. The detection time for an antigen can be dramatically reduced relative to conventional technologies. The technology can particularly be used, for example, to modify and reduce the detection time significantly... Agent: Eckert Seamans Cherin & Mellott

20080261202 - Tagged polyfunctional reagents capable of reversibly binding target substances in a ph-dependent manner: Polyfunctional reagents are disclosed that are capable of reversibly binding to target substances, for example nucleic acid, proteins, polypeptides, cells, cell components, microorganisms or viruses, for use in purifying or otherwise manipulating them. The reagents comprise a tagging group for manipulating and/or detecting the target substance when bound to the... Agent: Invitrogen Corporation C/o Intellevate

20080261208 - 2'-nitrobenzyl-modified ribonucleotides: This disclosure provides novel reversibly terminated ribonucleotides which can be used as a reagent for DNA sequencing reactions. Methods of sequencing nucleic acids using the disclosed nucleotides are also provided.... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo Attn: Patent Intake Customer No. 35437

20080261223 - Arl-1 specific antibodies: This invention provides antibodies immunologically specific for human ARL-1 (also referred to AKR1B10), a species of the aldo-keto reductase superfamily of proteins. The invention also provides methods of making and methods of using said antibodies.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080261213 - Assay: The invention relates to a method for screening for pre-eclampsia in a mammal, such as a human, by determining the amount and quality of foetal 2,3 bisphosphoglycerate mutase (2,3 BPGM) present. Reagents and kits for carrying out the method are also provided.... Agent: Barnes & Thornburg LLP

20080261210 - Assay method: The invention provides a cassette-based automated assay for homocysteine.... Agent: Bacon & Thomas, PLLC

20080261221 - Automated vntr genotyping method: The invention provides an automated VNTR genotyping method using multiple variable-number tandem repeats (VNTRs) loci based on mycobacterial interspersed repetitive units (MIRU) undergoing multiplex PGR and high throughput MEGABACE® capillary electrophoresis system. The method uses fluorescent dyes of 6-carboxytetramethylrhodamine(TAMRA), 6-carboxy fluorescein (FAM) and 6-carboxy-2′, 4, 4′, 5′, 7, 7′-hexachlorofluorescein (HEX)... Agent: Birch Stewart Kolasch & Birch

20080261226 - Biomarkers of neurodegenerative disease: The present invention provides biomarkers and diagnostic methods employing such biomarkers based on the discovery of genes that have a two-fold or greater difference in gene expression in the spinal cord of a pre-symptomatic mouse model of amyotrophic lateral sclerosis. Such biomarkers and diagnostic methods are useful for early detection... Agent: Biotechnology Law Group C/o Portfolioip

20080261218 - Detection of biomarkers for neuropsychiatric disorders: Systems and methods provide a comprehensive high-throughput approach toward the sequential identification, prioritization, verification, and validation of etiologic factors in neuropsychiatric disorders, some of which can also be utilized as biomarkers for these illnesses. The systems and methods determine patterns of gene expression in various tissues from various samples under... Agent: Schwegman, Lundberg & Woessner, P.A.

20080261231 - Diabetes gene: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect human diabetes mellitus predisposing gene, specifically the angiotensinogen (AGT) gene, some mutant alleles of which cause susceptibility to insulin-dependent diabetes mellitus (IDDM). More specifically, the... Agent: Myriad Genetics Inc. Intellecutal Property Department

20080261214 - Dna polymorphisms in sterol-regulator-element binding proteins: The invention relates to DNA polymorphisms in sterol regulator element binding proteins (SREBP) that are characteristic of a higher risk of genetic diseases in humans such as hyperchlolesterolemia. The corresponding polymorphisms, especially the polymorphisms on SREBP-1 and SREBP-2 are frequently observed in Alzheimer patients (SREBP-2). They are also characterized by... Agent: Richard F. Jaworski Cooper & Dunham LLP

20080261209 - Electrophoretic separation method for analyzing gene expression: The following invention relates to an improved method of quantitative or qualitative analysis of gene expression of a biological material.... Agent: Ostrolenk Faber Gerb & Soffen

20080261230 - Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes: Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080261216 - Herv group ii viruses in lymphoma and cancer: The present invention relates to compositions and methods for cancer diagnosis and therapy, including but not limited to, cancer markers. In particular, the present invention relates to HERV-K(HML-2) target titers as diagnostic markers, and HERV-K(HML-2) therapeutic targets for HIV-related cancers, and other cancers.... Agent: Casimir Jones, S.c.

20080261227 - Kinetic pcr assay for quantification of gene amplification on chromosome 17: Provided is a kinetic PCR (“kPCR”) assay for determining gene copy number of a target gene located on chromosome 17. The kPCR assay uses the MMP-28 gene located at the 17q11.2-17q12 loci as a control and thus, is capable of detecting gene copy number of any gene on chromosome 17... Agent: Siemens Corporation Intellectual Property Department

20080261225 - Method and kit for detecting a target protein using a dna aptamer: A method and a kit for detecting a target protein in a sample with a signal amplification strategy are provided. The signal amplification strategy is established for the aptamer-based molecular recognition of a target protein with concomitant release of single-stranded DNA (G-DNA), which binds complementarily to a single-stranded RNA comprising... Agent: Sughrue Mion, PLLC

20080261215 - Method for evaluating the allergen sensitivity of an individual: The present invention discloses a method for evaluating the allergen sensitivity of an individual and/or the clinical efficacy of an allergen immunotherapy comprising the steps: providing at least two samples selected from the group consisting of blood or fractions thereof, connective tissue, nasal, bronchial, skin or gut biopsy material from... Agent: Chalker Flores, LLP

20080261205 - Method for the simultaneous determination of blood group and platelet antigen genotypes: RBC and platelet (Plt) alloimmunization requires antigen-matched blood to avoid adverse transfusion reactions. Some blood collection facilities use unregulated Abs to reduce the cost of mass screening, and later confirm the phenotype with government approved reagents. Alternatively, RBC and Plt antigens can be screened by virtue of their associated single... Agent: David S. Resnick

20080261212 - Method of diagnosis/prognosis of human chronic lymphocytic leukemia comprising the profiling of lpl/adam genes: The present invention provides methods of diagnosis and prognosis of human chronic lymphocytic leukemia (CLL) in a patient in need thereof and methods to determine IgVH mutational status. The methods of the present invention involve measuring the expression profile of two known genes: LPL and ADAM29; and comparing the ratio... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080261207 - Method of measuring cancer susceptibility: An individual's susceptibility to cancer is assessed based on the individual's cellular response to mutagenic agents such as radiation. The level of a growth-suppressing marker is measured before and after the individual's cells are exposed to the mutagenic agent. The individual's susceptibility to cancer as a result of the mutagenic... Agent: Knobbe Martens Olson & Bear LLP

20080261217 - Methylation profile of cancer: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides methods of identifying methylation patterns in genes associated with specific cancers.... Agent: Andrus, Sceales, Starke & Sawall, LLP

20080261220 - Nucleic acid detection assays: The present invention relates to novel methods of producing oligonucleotides. In particular, the present invention provides an efficient, safe, and automated process for the production of large quantities of oligonucleotides.... Agent: Casimir Jones, S.c.

20080261206 - Oligonucleotide for detection of a microorganism, diagnostic kits and methods for detection of microorganisms using the oligonucleotide: The present invention relates to a method so called Bacterial Digitalcode System (BaDis) that identifies microorganism by using bacterial-specific, genus-specific and species-specific oligonucleotides from a variety of samples or specimens for detection and differential diagnosis of microorganism. Particularly, the present invention relates to bacterial-specific, genus-specific and species-specific oligonucleotides designed by... Agent: The Rafferty Patent Law Firm

20080261228 - Pca3 messenger rna species in benign and malignant prostate tissues: This invention concerns the discovery of two distinct PCA3 mRNA sequences. One of these sequences corresponds to a short PCA3 mRNA molecule whereas the other PCA3 RNA molecule is longer as it comprises an additional sequence between exon 3 and exon 4a. The short RNA is associated with prostate cancer... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080261224 - Pgc-1beta, a novel pgc-1 homologue and uses therefor: The invention provides isolated nucleic acid molecules, designated PGC-1β nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1β nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20080261204 - Polynucleotide ligation reactions: The method of the invention is useful in quantifying the absolute or relative number of unique molecules present in a sample after carrying out an analysis procedure on the sample, and comprises the steps of: (i) attaching a unique molecular tag to substantially all of the molecules in the sample;... Agent: Marshall, Gerstein & Borun LLP

20080261219 - Polynucleotide primers: A polynucleotide primer comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 1 to 18, 21 to 45 or 74 to 77.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080261222 - Rapid and comprehensive identification of prokaryotic organisms: An improved method for rapid identification of microorganisms is disclosed, along with sequences of PCR primers optimized for this purpose. The primers are designed based on information analysis of sequences from a large number of organism to amplify certain segments of genomic DNA whose sequences are unique among different organisms.... Agent: Lathrop & Gage Lc

20080261229 - Simultaneous rapid detection of microbes: The invention includes a method of simultaneously detecting the presence or absence of more than one microbe class (e.g., bacteria, yeast, and mold) in a sample. The method can include the step of applying a sample suspected of containing more than one microbe class to a growth medium, optionally fragmenting... Agent: Intellectual Property Group Fredrikson & Byron, P.A.

20080261211 - Variants in complement regulatory genes predict age-related macular degeneration: Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and... Agent: Townsend And Townsend And Crew, LLP

20080261233 - Assessment of biological activity of hepatocyte growth factor (hgf): In the present invention the methods for recognition of biologically active hepatocyte growth factor efficient for using in therapeutic components are presented. The biological activity can be determined using: i) an in vitro model of restitution of damaged cells, and/or ii) affinity measurements or epitope mapping using SPR, with the... Agent: Dinsmore & Shohl, LLP

20080261236 - Fgf21 upregulates expression of glut-1 in a beta klotho-dependent manner: A method is provided to identify a modulator of βKlotho-dependant glucose transporter-1 (GLUT-1) upregulation that specifically modulates interaction of βKlotho and an FGFR.... Agent: Richard Aron Osman

20080261235 - Novel green and orange fluorescent labels and their uses: The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulpbonic and disulphonic... Agent: David R. Saliwanchik Saliwanchik, Lloyd & Saliwanchik

20080261234 - Peptides and their use in assays for cardiovascular disease: A peptide having affinity for oxidised low density lipoprotein, in cyclised or multimeric form is useful in an enzyme immunosolvent assay, to detect oxLDL which is a marker of coronary heart disease.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080261232 - Use of precursors of enkephalins and/or their fragments in medical diagnostics: The invention relates to the diagnosis of disease based on the presence of biochemical components in human or animal body fluids, tissues and/or biomaterials. More specifically the invention relates to the use of precursors of enkephalins and/or its fragments isolated from body fluids, tissues or other biomaterials as a marker... Agent: Heslin Rothenberg Farley & Mesiti PC

20080261237 - Inositol-phosphate derivatives and method of detecting inositol-1-phosphate: e

20080261242 - Highly sensitive system and methods for analysis of troponin: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.... Agent: Wilson Sonsini Goodrich & Rosati

20080261245 - Antibodies, including fv molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use: Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to anti-mesothelin... Agent: Townsend And Townsend And Crew, LLP

20080261244 - Compositions and methods for treating and diagnosing pancreatic cancer: The present invention relates to the field of oncology and provides novel compositions and methods for diagnosing and treating pancreatic cancer. In particular, the present invention provides pancreatic cancer stem cells useful for the study, diagnosis, and treatment of solid tumors.... Agent: Casimir Jones, S.c.

20080261243 - Detection of elevated levels of her-2/neu protein on circulating cancer cells and treatment: The expression of Her-2/neu protein on circulating cancer cells in a blood sample is detected by isolating the cancer cells from the blood sample and then performing on the isolated cancer cells a sensitive Her-2/neu immunoassay. A positive result indicates the expression of Her-2/neu on cancer cells in the blood... Agent: Wellstat Management Company. LLC

20080261246 - Tissue inhibitor of matrix metalloproteinases type-1 (timp-1) as a cancer marker and postoperative marker for minimal residual disease or recurrent disease in patients with a prior history of cancer: The present invention describes a method for determining whether an individual is suffering from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual. The present invention furthermore describes a method for determining whether an individual is suffering from minimal residual disease or recurrent... Agent: Roberts Mlotkowski Safran & Cole, P.C. Intellectual Property Department

20080261247 - Method of detecting red cell antigen-antibody reactions: e

20080261248 - Method of detecting red cell antigen-antibody reactions:

20080261239 - Detecting molecular interactions: The present disclosure features a variety of compositions, kits, and methods that are useful for, inter alia, detecting and/or analyzing an interaction between two molecules, a target molecule and a target-specific binding agent which can be, e.g., proteins, nucleic acids, saccharides or polysaccharides, small molecules, or combinations of any of... Agent: Fish & Richardson PC

20080261240 - Method: A method for attenuating a microorganism which comprises inhibiting in the microorganism a metabolic pathway essential for viability, by promoting use of the substrate of the pathway in a different metabolic pathway which is non-essential to the microorganism whereby the substrate is unavailable to the essential pathway and the micro... Agent: Astrazeneca R&d Boston

20080261238 - Method for differentiation of factor xiii deficiency states in relation to fibrinogen deficiency states using thrombelastographic techniques: The invention relates to a method for determining a factor XIII deficiency, a method for determining a fibrinogen deficiency, and a method for differentiating between a factor XIII deficiency and a fibrinogen deficiency by means of thrombelastographic techniques. On the basis of the evaluation of the thrombelastographic parameters, a rapid... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080261241 - Targeted ubiquitination of proteins and screening methods using a new class of ubiquitin ligase proteins: Members of the IpaH superfamily constitute a novel class of E3 ubiquitin ligases which are useful for engineering products which modulate trafficking and destruction of target proteins inside a cell and useful targets for identifying new antimicrobial molecules which modulate, especially inhibit, E3 ligases.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080261249 - Detecting and quantifying host cell proteins in recombinant protein products: A single-step immunoassay method, kit, and reagents for detecting and quantifying contaminant host cell proteins in a recombinant protein sample are described. The method includes the step of adding to immobilized medium comprising a capture reagent including anti-host cell protein antibodies, both the recombinant protein sample and a detection reagent... Agent: Nikolaos C. George Jones Day

20080261250 - Methods for assessing the risk for development of cardiovascular disease: The present invention relates to diagnostic tests, methods and kits that are useful to assess a subject's risk of developing a pathologic condition related in part to the presence of HDL oxidation product. Measuring the quantity of one or more HDL oxidation products present in the blood is useful in... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20080261251 - Monoclonal antibodies, hybridomas, improved method for determining the protein ptx3 and kit for said determination: Method for determining the level of PTX3 protein in a sample of a biological fluid; hybridoma capable of producing a rat anti-PTX3 monoclonal antibody where said hybridoma is selected from the group comprising MNB10 and Pen-3; specific anti-PTX3 rat monoclonal antibody selected from the monoclonal antibodies produced by the hybridomas... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080261252 - Soluble interleukin-1 receptor accessory molecule: The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20080261253 - Methods and kits for the diagnosis of galactosemia: Provided are methods for the detection and diagnosis of galactosemia. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of galactosemia. At least two new biomarkers for galactosemia are... Agent: Foley And Lardner LLP Suite 500

20080261254 - Procedure for the determination of the reaction lag phase in an analyte-dependent reaction: The invention is in the field of analytical technique and relates to an improved procedure for determining the concentration or activity of an analyte, an analyte-dependent detection reaction being set in motion and the reaction kinetics determined being evaluated. The procedure makes possible an individual determination of the lag phase... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080261256 - Methods of assaying receptor activity and constructs useful in such methods: Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process. Constructs useful in such methods are... Agent: Morgan, Lewis & Bockius, LLP

20080261255 - Proteins, sensors, and methods of characterizing analytes using the same: A protein sensing molecule is capable of binding an analyte in a sample. The protein sensing molecule includes a first detectable quality that changes in a concentration dependent manner when the protein sensing molecule is bound to the analyte. The protein sensing molecule also includes a second detectable quality that... Agent: Rene A. Vazquez Williams Mullen

20080261259 - Culture media for expansion and differentiation of epidermal cells and uses thereof for in vitro growth of hair follicles: The invention is directed to a chemically defined animal cell culture media, and methods for preparing such a medium, wherein the media are suitable for culturing epidermal cells, preferably human epidermal cells, including cells of the hair follicle. The invention further provides for methods of culturing epidermal cells, hair follicles,... Agent: Wilmerhale/columbia University

20080261257 - Fluorescent proteins and related methods and compounds: The invention includes fusion polypeptides including a first fluorescent protein, e.g., a FRET donor protein, a second fluorescent protein, e.g., a FRET acceptor protein, and, linked to at least one of the fluorescent (e.g., FRET donor or FRET acceptor) proteins, an Fc-region of an immunoglobulin. The polypeptide can be immobilized... Agent: Fish & Richardson PC

20080261258 - Immune cell biosensors and methods of using same: The present invention relates to immunological cells that are useful in detecting changes in physiological states, which provide for methods of diagnosing diseases or monitoring the course of patient therapy. Also provided are arrays of antigen presenting cell-specific markers for detecting changes in physiological states, and methods of detecting such... Agent: Foley & Lardner LLP

20080261261 - System/unit and method employing a plurality of magnetoelastic sensor elements for automatically quantifying parameters of whole blood and platelet-rich plasma: A system/analyzer-unit and method/platform—using information obtained from at least one, adapted for a plurality of, magnetoelastic sensor elements in contact with one or more samples comprising blood from a patient—for automatically quantifying one or more parameters of the patient's blood. Information obtained from emissions measured from each of the sensor... Agent: Jean M. Macheledt

20080261260 - Use of gelsolin to treat infections: The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression.... Agent: Wolf Greenfield & Sacks, P.C.

20080261262 - Lysis/resealing process and device for incorporating an active ingredient, in particular asparaginase or inositol hexaphosphate, in erythrocytes: Lysis/resealing process for preparing erythrocytes which contain an active ingredient (e.g. aspariginase or inositol hexaphosphate), the process comprising the following steps: (1) placing a globular concentrate in suspension in an isotonic solution having a haematocrit level which is equal to or greater than 65%, with refrigeration at from +1 to... Agent: Stites & Harbison PLLC

20080261263 - In vitro evaluation of micro-organisms and their antimicrobial agent susceptibilities: A method of identifying a micro-organism and determining the susceptibility of the micro-organism to an antimicrobial agent by inserting a sample of the micro-organism in a primary culture container and allowing the micro-organism to multiply. The primary culture is then divided into a plurality of secondary cultures and the metabolic... Agent: D. Peter Hochberg Co. L.p.a.

20080261264 - Culture medium for detecting of clostridium perfringens: The invention relates to a culture medium for the detection of Clostridium perfringens. The invention consists in: dissolving protease peptone, microbiological peptone, yeast extract, sodium bisulphite and ferric ammonium citrate in deonized water; sterilising said solution at 121° C. for 15 minutes and cooling same; and, subsequently, adding cycloserine and... Agent: Merchant & Gould PC

20080261265 - Histological staining composition and methods related thereto: Embodiments of the invention relate to a method for histological staining, the method comprises immersing a tissue sample in a staining solution sufficient to impregnate the tissue sample, dehydrating the tissue sample, embedding the tissue sample, cutting the tissue sample, developing the tissue sample, fixing the tissue sample and mounting... Agent: Schwegman, Lundberg & Woessner, P.A.

20080261266 - Methods and compositions for a microemulsion-based tissue treatment: The invention is directed to methods and compositions for deparaffinizing paraffin-embedded biological samples for subsequent tissue staining. The compositions are microemulsions that may include water/oil/surfactant microemulsions, and optionally a cosurfactant. The microemulsions enable deparaffinization without the use of xylene or toluene, and also enable solvent exchange without the use of... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20080261268 - 5-substituted hydantoin racemase, dna encoding the same, recombinant dna, transformed cell, and process for production of optically active n-carbamylamino acid or optically active amino acid: Disclosed are a novel hydantoin racemase and a process for producing an optically active N-carbamylamino acid or an optically active amino acid using the hydantoin racemase. A novel hydantoin racemase isolated and purified from Bacillus sp. Strain KNK519HR; a gene encoding the hydantoin racemase; a recombinant plasmid having the gene... Agent: Sughrue Mion, PLLC

20080261269 - Alleles of the oxyr gene from coryneform bacteria: The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.... Agent: Smith, Gambrell & Russell

20080261267 - Cellulases from rumen: The invention provides polypeptides coding for new cellulases from rumen, particularly from rumen ecosystem. The invention also relates to functional fragments or functional derivatives thereof as well as to nucleic acids encoding the polypeptides of the invention, vectors and host cells containing said nucleic acids, a method for producing the... Agent: Klauber & Jackson

20080261271 - Expression of hiv polypeptides and production of virus-like particles: The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation... Agent: Novartis Vaccines And Diagnostics Inc.

20080261272 - Fungal cell wall synthesis gene: A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these... Agent: Townsend And Townsend And Crew, LLP

20080261273 - Process for producing hmg-coa reductase inhibitors: r

20080261270 - Soluble erbb3 receptor isoforms: The present invention discloses a system and method using isoforms of the human ErbB3 receptor as negative regulators of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present invention also discloses a system and method of one such isoform, p85-sErbB3 binding to heregulin with an affinity comparable to that of full-length... Agent: Cohen & Grigsby, P.C.

20080261274 - Restoration of cholesterol independence and its use as a selectable marker in ns0 cell culture: Gene complementation is used to restore cholesterol independence in NS lineage murine myeloma cells, such as NSO and NS 1, yielding a selectable system for recombinant production of polynucleotides and polypeptides.... Agent: Gargi Seth

20080261275 - Cdna production from cells after laser microdissection: The present invention provides a new procedure for the synthesis of CDNA from single cells after microdissection. It has the advantage that it is cost-efficient and can be carried out quickly with only few steps, even by less skilled laboratory employees. For the first time, the time-consuming and risky step... Agent: K.f. Ross P.C.

20080261276 - Micro-fluidic device based upon active matrix principles: A micro-fluidic device (1) including a two-dimensional array of a plurality of components (2) for processing a fluid and/or for sensing properties of the fluid is suggested. Each component (2) is coupled to at least one control terminal (9,10) enabling an active matrix to change the state of each component... Agent: Philips Intellectual Property & Standards

20080261277 - Prna chimera: A circularly permuted chimeric pRNA molecule carrying a stabilized biologically active RNA, such as a ribozyme.... Agent: Mueting, Raasch & Gebhardt, P.A.

20080261278 - Method for producing l-amino acid using bacteria belonging to the genus escherichia: There is provided a method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine using a bacterium belonging to the genus Escherichia wherein the L-amino acid productivity of the bacterium is enhanced by enhancing the activities of the proteins coded by the b2682 and b2683 genes, or the protein coded... Agent: Cermak & Kenealy LLP Acs LLC

20080261279 - Method for producing l-amino acid using bacteria belonging to the genus escherichia: A method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine is provided using Escherichia bacteria wherein the L-amino acid productivity of the bacteria is enhanced by increasing the activity of proteins encoded by the b2682 and b2683 genes, or proteins encoded by the b1242 or b3434 gene.... Agent: Cermak & Kenealy LLP Acs LLC

20080261280 - Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms: Disclosed are the uses of specific genes of the mevalonate and isoprenoid biosynthetic pathways, and of inactive gene sites (the pseudogene) to (1) enhance biosynthesis of isopentenyl diphosphate, dimethylallyl diphosphate and isoprenoid pathway derived products in the plastids of transgenic plants and microalgae, (2) create novel antibiotic resistant transgenic plants... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080261281 - Novel carbonyl reductase, gene thereof and method of using the same: s

20080261282 - Fermentation process for preparing coenzyme q10 by the recombinant agrobacterium tumefaciens: The present invention relates to a transformed Agrobacterium tumefaciens BNQ-pGPRX11 (Accession No. KCCM-10554) harboring a recombinant expression vector (pGPRX11). Further, the present invention also provides a fermentation method for maximum production of coenzyme Q10 using a transformed Agrobacterium tumefaciens deposited to Korean Culture Center of Microorganism with accession number KCCM-10554... Agent: Kenyon & Kenyon LLP

20080261283 - Biooxidation capabilities of candida sp: A bioprocess for producing carboxylic acids, alcohols and aldehydes is provided by culturing Candida sp. in a fermentation medium containing various defined substrates.... Agent: Synnestvedt & Lechner LLP

20080261284 - Method for the production of lactic acid or a salt thereof by simultaneous saccharification and fermentation of starch: The present invention pertains to a method for the production of lactic acid or a salt thereof, wherein starch is subjected to a process of simultaneous saccharification and fermentation, the method comprising saccharifying starch in a medium comprising at least a glucoamylase and simultaneously fermenting the starch using a microorganism,... Agent: Oliff & Berridge, PLC

20080261285 - Method for the production of lactic acid or a salt thereof by simultaneous saccharification and fermentation of starch: The present invention pertains to a method for the production of lactic acid or a salt thereof wherein starch is subjected to a process of simultaneous saccharification and fermentation, the method comprising saccharifying starch in a medium comprising at least a glucoamylase and simultaneously fermenting the starch using a microorganism,... Agent: Oliff & Berridge, PLC

20080261286 - Methods for producing optically active alpha-hydroxy amides: An enzyme exhibiting high stereoselectivity was purified from a number of Saccharomyces cerevisiae enzymes with 2-chlorobenzoyl formamide-reducing activity, and the biochemical properties of the purified enzyme were analyzed. The analysis of a partial internal amino acid sequence of the purified enzyme revealed that the enzyme may be encoded by the... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080261287 - Metabolic engineering of xylos fermentation: The present invention relates to further genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers the host cell the ability of isomerising xylose to xylulose. The further genetic modifications are aimed at improving the efficiency of xylose metabolism and include e.g. reduction... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080261288 - Micro-organ device: A method for fabricating a micro-organ device comprises providing a microscale support having one or more microfluidic channels and one or more micro-chambers for housing a micro-organ and printing a micro-organ on the microscale support using a cell suspension in a syringe controlled by a computer-aided tissue engineering system, wherein... Agent: Nasa Johnson Space Center

20080261289 - Compositions comprising viruses and methods for concentrating virus preparations: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.... Agent: Townsend And Townsend And Crew, LLP

20080261290 - Tetrahymena heat inducible promoters and their use: c

20080261291 - Method of obtaining cyanogenic glycoside and related glycosides, as well as genin and sapogenins derivatives of plants of the family sapotaceae for the preparation of cosmetics and dermatological compositions: Procedure for the obtaining of genin and sapogenins extracts by enzymatic hydrolysis of kernels derived of the family Sapotaceae, genus Calocarpum, Chrysophyllum and Lucuma. The enzymes that catalyzes the hydrolysis are exogenous β-glucosidases, of vegetable or microbial origin. The process uses mainly diverse kernel (seeds removed of the endocarp) derived... Agent: Hoffman Wasson & Gitler, P.c Crystal Center 2, Suite 522

20080261293 - Homogeneous method to prepare sperm dna from sexual assault cases: The present invention provides a method for the isolation of sperm DNA from swabs taken from rape victims without having to perform a change in buffers. Non-sperm cells from the victim are digested with an enzyme and solubilized, and then in the same buffer an enzyme capable of digesting soluble... Agent: Alex Garvin

20080261292 - Method enabling the use of extracellular ribonucleic acid (rna) extracted from plasma or serum to detect, monitor or evaluate cancer or premalignant conditions: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound RNA, lipid-RNA complexes, lipoprotein (proteolipid)-RNA complexes, protein-RNA... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080261294 - Apparatus for chemiluminescent assay and detection: An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement... Agent: Mattingly, Stanger, Malur & Brundidge, P.C.

20080261295 - Cell sorting system and methods: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of... Agent: O''melveny & Myers LLP Ip&t Calendar Department La-1118

20080261296 - Process challenge device for assessing the effective performance of a biocontamination deactivation process: A process challenge device (PCD) for determining the effectiveness of a microbial deactivation process that uses a vaporous deactivating agent (e.g., vaporized hydrogen peroxide) as a deactivating agent. The PCD includes first and second layers that are joined together to form (1) a chamber dimensioned to receive a biological and/or... Agent: Kusner & Jaffe Highland Place Suite 310

20080261297 - Assay device: An assay device (1) having a rotatable platform (2) with a test chamber (6) and a sensor (20) which undergoes displacement when subject to a particular substance such as a chemical, biological species or other organism. The sensor is a cantilever beam (21) with a porous section (23) to enhance... Agent: Townsend And Townsend And Crew, LLP

20080261298 - Method and device for the multiplex analysis of cells and tissues: This invention is used for the multiplex analysis method of cells or tissues by combination of multiple cubicles and permeable membrane. Utilizing the diffusion based reagents administration; cells and tissues in multiple cubicles receive signals evenly in their cubicles as parallel manner. This device makes efficient multiplex cells or tissues... Agent: Hiroyuki Yonekawa

20080261299 - Pneumatic bioreactor: A pneumatic bioreactor having a containment vessel which includes a semi-cylindrical concavity defined by the vessel bottom. A mixing apparatus includes a rotational mixer rotatably mounted within the containment vessel about a horizontal axis. The rotational mixer has buoyancy-driven mixing cavities which are fed by a gas supply beneath the... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080261300 - Synthetic genes: The invention provides strategies, methods, vectors, reagents, and systems for production of synthetic genes, production of libraries of such genes, and manipulation and characterization of the genes and corresponding encoded polypeptides. In one aspect, the synthetic genes can encode polyketide synthase polypeptides and facilitate production of therapeutically or commercially important... Agent: Townsend And Townsend And Crew, LLP

20080261301 - Antibody composition-producing cell: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for... Agent: Sughrue-265550

20080261302 - Methods of diagnosing or treating neurological diseases and cell degeneration: The invention discloses an isolated nucleic acid molecule encoding a protein molecule, the function of which is to protect cells against degeneration and/or cell death, wherein the amino acid sequence of the protein comprises the sequence shown in SEQ ID NO. 2 or a functional variant thereof.... Agent: Jacobson Holman PLLC

20080261303 - Method and medicament for inhibiting the expression of a given gene: The present invention relates to the specific inhibition of expression of a target gene in mammals using a short double stranded RNA. The dsRNA is less than 49 nucleotides in length and has a nucleotide sequence which is complementary to at least a part of the target gene. The dsRNAs... Agent: Lowrie, Lando & Anastasi, LLP A2038

20080261304 - Methods and compositions for enhancing delivery of double-stranded rna or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells: A double-stranded RNA, preferably a small, interfering (si)RNA or a siHybrid, to which cholesterol moieties are linked.... Agent: Nastech Pharmaceutical Company Inc

20080261305 - Tgf-beta-mediated osteogenic differentiation of mesenchymal stem cells: Methods and compositions are provided for the culture of MSC to provide osteogenic progenitor cells.... Agent: Bozicevic, Field & Francis LLP Stanford University Office Of Technology Licensing

20080261306 - Method for creating perfusable microvessel systems: A method for creating networks of perfusable microvessels in vitro. A mandrel is drawn through a matrix to form a channel through the matrix. Cells are injected into the channel. The matrix is incubated to allow the cells to attach inside the channel. The channel is perfused to remove unattached... Agent: George A Leone, Sr Citadel Patent Law

20080261307 - Method of isolating and proliferating autologous antigen-specific cd8+ t cell using anti-4-1bb antibodies: Provided are methods of isolating and proliferating antigen-specific CD8+ T cells using anti-4-1BB antibodies. The methods of isolating and proliferating CD8+ T cells may yield cells at a higher recovery rate than a conventional isolation method, and the isolation method using humanized anti-4-1BB antibodies may also yield cells at a... Agent: Reed Smith LLP Suite 1400

20080261308 - Dry powder cell culture products and methods of production thereof: The present invention relates to nutritive medium, medium supplement, media subgroup and buffer formulations. The present invention provides powder nutritive medium, medium supplement and medium subgroup formulations, e.g., cell culture medium supplements (including powdered sera such as powdered fetal bovine serum (FBS)), medium subgroup formulations and cell culture media comprising... Agent: Invitrogen Corporation C/o Intellevate

20080261309 - In vitro multiplication of hoodia plants: A tissue culture micropropagation process for Hoodia plants, which achieves new shoots in the multiplication stage of the process by using an inventive combination of phytohormones.... Agent: Unilever Patent Group

20080261310 - In vitro rooting of hoodia plants: An in vitro tissue culture process of rooting Hoodia explants by using an inventive combination of phytohormones.... Agent: Unilever Patent Group

20080261311 - In vivo incorporation of unnatural amino acids: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.... Agent: Quine Intellectual Property Law Group, P.C.

20080261196 - Naphthalene diimide-zn(ii) complex having selectivity for pyrophosphate, preparation method thereof and detecting method of pyrophosphate using the same: The present invention provides a novel fluorescent chemosensor including a naphthalene diimide-Zn(II) complex, which can efficiently recognize pyrophosphate (PPi) at pH 7.4. The fluorescent chemosensor exhibits a new kind of excimer fluorescence, which is selective for PPi in 100% aqueous solution. Further, since the naphthalene diimide-Zn(II) complex of the present... Agent: Joseph Hyosuk Kim, Ph.d. Jhk Law

20080261203 - Detection of epstein-barr virus: The invention provides methods to detect EBV in biological samples using real-time PCR. Primers and probes for the detection of EBV are provided by the invention.... Agent: Fish & Richardson P.C.

20080261200 - Detection of nucleic acid mutations: A method for detecting a mutation in a target nucleic acid sequence in a sample, the target nucleic acid sequence comprising a first DNA strand and optionally the complementary strand thereof, said method comprising: (a) adding a detection primer to the nucleic acid, wherein the detection primer binds to the... Agent: Evan Law Group LLC

20080261198 - Diagnostic primers and method for detecting avian influenza virus subtype h5 and h5n1: The present invention provides primers directed to conserved regions of the HA and NA genes of avian influenza virus subtypes H5 or H5N1, and provides a method for detecting avian influenza subtype H5 or H5N1.... Agent: Klarquist Sparkman, LLP

20080261201 - Methods and compounds to alter virus infection: The invention provides a method to identify an agent that alters parvovirus transduction of mammalian cells. Also provided is a method to enhance transgene expression in a mammalian cell, as well as a method to identify an agent that alters NADPH oxidase activity in parvovirus transduced mammalian cells.... Agent: Schwegman, Lundberg & Woessner, P.A.

20080261197 - Nucleotide sequences of hiv-1 group (or subgroup) o retroviral antigens: An HIV-1 type (or subtype) O retrovirus protein, or a natural or synthetic polypeptide or peptide including at least a part of said protein, which is capable of being recognised by antibodies isolated from a serum resulting from infection by an HIV-1 type O VAU strain or an HIV-1 type... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080261199 - Rapid detection processes and related compositions: An improved detection method is described for an antigen such as a chemical compound, a peptide, or a nucleic acid. The detection time for an antigen can be dramatically reduced relative to conventional technologies. The technology can particularly be used, for example, to modify and reduce the detection time significantly... Agent: Eckert Seamans Cherin & Mellott

20080261202 - Tagged polyfunctional reagents capable of reversibly binding target substances in a ph-dependent manner: Polyfunctional reagents are disclosed that are capable of reversibly binding to target substances, for example nucleic acid, proteins, polypeptides, cells, cell components, microorganisms or viruses, for use in purifying or otherwise manipulating them. The reagents comprise a tagging group for manipulating and/or detecting the target substance when bound to the... Agent: Invitrogen Corporation C/o Intellevate

20080261208 - 2'-nitrobenzyl-modified ribonucleotides: This disclosure provides novel reversibly terminated ribonucleotides which can be used as a reagent for DNA sequencing reactions. Methods of sequencing nucleic acids using the disclosed nucleotides are also provided.... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo Attn: Patent Intake Customer No. 35437

20080261223 - Arl-1 specific antibodies: This invention provides antibodies immunologically specific for human ARL-1 (also referred to AKR1B10), a species of the aldo-keto reductase superfamily of proteins. The invention also provides methods of making and methods of using said antibodies.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080261213 - Assay: The invention relates to a method for screening for pre-eclampsia in a mammal, such as a human, by determining the amount and quality of foetal 2,3 bisphosphoglycerate mutase (2,3 BPGM) present. Reagents and kits for carrying out the method are also provided.... Agent: Barnes & Thornburg LLP

20080261210 - Assay method: The invention provides a cassette-based automated assay for homocysteine.... Agent: Bacon & Thomas, PLLC

20080261221 - Automated vntr genotyping method: The invention provides an automated VNTR genotyping method using multiple variable-number tandem repeats (VNTRs) loci based on mycobacterial interspersed repetitive units (MIRU) undergoing multiplex PGR and high throughput MEGABACE® capillary electrophoresis system. The method uses fluorescent dyes of 6-carboxytetramethylrhodamine(TAMRA), 6-carboxy fluorescein (FAM) and 6-carboxy-2′, 4, 4′, 5′, 7, 7′-hexachlorofluorescein (HEX)... Agent: Birch Stewart Kolasch & Birch

20080261226 - Biomarkers of neurodegenerative disease: The present invention provides biomarkers and diagnostic methods employing such biomarkers based on the discovery of genes that have a two-fold or greater difference in gene expression in the spinal cord of a pre-symptomatic mouse model of amyotrophic lateral sclerosis. Such biomarkers and diagnostic methods are useful for early detection... Agent: Biotechnology Law Group C/o Portfolioip

20080261218 - Detection of biomarkers for neuropsychiatric disorders: Systems and methods provide a comprehensive high-throughput approach toward the sequential identification, prioritization, verification, and validation of etiologic factors in neuropsychiatric disorders, some of which can also be utilized as biomarkers for these illnesses. The systems and methods determine patterns of gene expression in various tissues from various samples under... Agent: Schwegman, Lundberg & Woessner, P.A.

20080261231 - Diabetes gene: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect human diabetes mellitus predisposing gene, specifically the angiotensinogen (AGT) gene, some mutant alleles of which cause susceptibility to insulin-dependent diabetes mellitus (IDDM). More specifically, the... Agent: Myriad Genetics Inc. Intellecutal Property Department

20080261214 - Dna polymorphisms in sterol-regulator-element binding proteins: The invention relates to DNA polymorphisms in sterol regulator element binding proteins (SREBP) that are characteristic of a higher risk of genetic diseases in humans such as hyperchlolesterolemia. The corresponding polymorphisms, especially the polymorphisms on SREBP-1 and SREBP-2 are frequently observed in Alzheimer patients (SREBP-2). They are also characterized by... Agent: Richard F. Jaworski Cooper & Dunham LLP

20080261209 - Electrophoretic separation method for analyzing gene expression: The following invention relates to an improved method of quantitative or qualitative analysis of gene expression of a biological material.... Agent: Ostrolenk Faber Gerb & Soffen

20080261230 - Fermentive production of isobutanol using highly active ketol-acid reductoisomerase enzymes: Methods for the fermentative production of isobutanol is provided by the fermentative growth of a recombinant microorganism expressing a highly active ketol-acid reductoisomerase enzyme in addition to other enzymes required for conversion of glucose to isobutanol.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080261216 - Herv group ii viruses in lymphoma and cancer: The present invention relates to compositions and methods for cancer diagnosis and therapy, including but not limited to, cancer markers. In particular, the present invention relates to HERV-K(HML-2) target titers as diagnostic markers, and HERV-K(HML-2) therapeutic targets for HIV-related cancers, and other cancers.... Agent: Casimir Jones, S.c.

20080261227 - Kinetic pcr assay for quantification of gene amplification on chromosome 17: Provided is a kinetic PCR (“kPCR”) assay for determining gene copy number of a target gene located on chromosome 17. The kPCR assay uses the MMP-28 gene located at the 17q11.2-17q12 loci as a control and thus, is capable of detecting gene copy number of any gene on chromosome 17... Agent: Siemens Corporation Intellectual Property Department

20080261225 - Method and kit for detecting a target protein using a dna aptamer: A method and a kit for detecting a target protein in a sample with a signal amplification strategy are provided. The signal amplification strategy is established for the aptamer-based molecular recognition of a target protein with concomitant release of single-stranded DNA (G-DNA), which binds complementarily to a single-stranded RNA comprising... Agent: Sughrue Mion, PLLC

20080261215 - Method for evaluating the allergen sensitivity of an individual: The present invention discloses a method for evaluating the allergen sensitivity of an individual and/or the clinical efficacy of an allergen immunotherapy comprising the steps: providing at least two samples selected from the group consisting of blood or fractions thereof, connective tissue, nasal, bronchial, skin or gut biopsy material from... Agent: Chalker Flores, LLP

20080261205 - Method for the simultaneous determination of blood group and platelet antigen genotypes: RBC and platelet (Plt) alloimmunization requires antigen-matched blood to avoid adverse transfusion reactions. Some blood collection facilities use unregulated Abs to reduce the cost of mass screening, and later confirm the phenotype with government approved reagents. Alternatively, RBC and Plt antigens can be screened by virtue of their associated single... Agent: David S. Resnick

20080261212 - Method of diagnosis/prognosis of human chronic lymphocytic leukemia comprising the profiling of lpl/adam genes: The present invention provides methods of diagnosis and prognosis of human chronic lymphocytic leukemia (CLL) in a patient in need thereof and methods to determine IgVH mutational status. The methods of the present invention involve measuring the expression profile of two known genes: LPL and ADAM29; and comparing the ratio... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080261207 - Method of measuring cancer susceptibility: An individual's susceptibility to cancer is assessed based on the individual's cellular response to mutagenic agents such as radiation. The level of a growth-suppressing marker is measured before and after the individual's cells are exposed to the mutagenic agent. The individual's susceptibility to cancer as a result of the mutagenic... Agent: Knobbe Martens Olson & Bear LLP

20080261217 - Methylation profile of cancer: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides methods of identifying methylation patterns in genes associated with specific cancers.... Agent: Andrus, Sceales, Starke & Sawall, LLP

20080261220 - Nucleic acid detection assays: The present invention relates to novel methods of producing oligonucleotides. In particular, the present invention provides an efficient, safe, and automated process for the production of large quantities of oligonucleotides.... Agent: Casimir Jones, S.c.

20080261206 - Oligonucleotide for detection of a microorganism, diagnostic kits and methods for detection of microorganisms using the oligonucleotide: The present invention relates to a method so called Bacterial Digitalcode System (BaDis) that identifies microorganism by using bacterial-specific, genus-specific and species-specific oligonucleotides from a variety of samples or specimens for detection and differential diagnosis of microorganism. Particularly, the present invention relates to bacterial-specific, genus-specific and species-specific oligonucleotides designed by... Agent: The Rafferty Patent Law Firm

20080261228 - Pca3 messenger rna species in benign and malignant prostate tissues: This invention concerns the discovery of two distinct PCA3 mRNA sequences. One of these sequences corresponds to a short PCA3 mRNA molecule whereas the other PCA3 RNA molecule is longer as it comprises an additional sequence between exon 3 and exon 4a. The short RNA is associated with prostate cancer... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080261224 - Pgc-1beta, a novel pgc-1 homologue and uses therefor: The invention provides isolated nucleic acid molecules, designated PGC-1β nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1β nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20080261204 - Polynucleotide ligation reactions: The method of the invention is useful in quantifying the absolute or relative number of unique molecules present in a sample after carrying out an analysis procedure on the sample, and comprises the steps of: (i) attaching a unique molecular tag to substantially all of the molecules in the sample;... Agent: Marshall, Gerstein & Borun LLP

20080261219 - Polynucleotide primers: A polynucleotide primer comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 1 to 18, 21 to 45 or 74 to 77.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080261222 - Rapid and comprehensive identification of prokaryotic organisms: An improved method for rapid identification of microorganisms is disclosed, along with sequences of PCR primers optimized for this purpose. The primers are designed based on information analysis of sequences from a large number of organism to amplify certain segments of genomic DNA whose sequences are unique among different organisms.... Agent: Lathrop & Gage Lc

20080261229 - Simultaneous rapid detection of microbes: The invention includes a method of simultaneously detecting the presence or absence of more than one microbe class (e.g., bacteria, yeast, and mold) in a sample. The method can include the step of applying a sample suspected of containing more than one microbe class to a growth medium, optionally fragmenting... Agent: Intellectual Property Group Fredrikson & Byron, P.A.

20080261211 - Variants in complement regulatory genes predict age-related macular degeneration: Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polymorphisms in the BF, C2 and/or CFH genes. Microarrays and... Agent: Townsend And Townsend And Crew, LLP

20080261233 - Assessment of biological activity of hepatocyte growth factor (hgf): In the present invention the methods for recognition of biologically active hepatocyte growth factor efficient for using in therapeutic components are presented. The biological activity can be determined using: i) an in vitro model of restitution of damaged cells, and/or ii) affinity measurements or epitope mapping using SPR, with the... Agent: Dinsmore & Shohl, LLP

20080261236 - Fgf21 upregulates expression of glut-1 in a beta klotho-dependent manner: A method is provided to identify a modulator of βKlotho-dependant glucose transporter-1 (GLUT-1) upregulation that specifically modulates interaction of βKlotho and an FGFR.... Agent: Richard Aron Osman

20080261235 - Novel green and orange fluorescent labels and their uses: The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulpbonic and disulphonic... Agent: David R. Saliwanchik Saliwanchik, Lloyd & Saliwanchik

20080261234 - Peptides and their use in assays for cardiovascular disease: A peptide having affinity for oxidised low density lipoprotein, in cyclised or multimeric form is useful in an enzyme immunosolvent assay, to detect oxLDL which is a marker of coronary heart disease.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080261232 - Use of precursors of enkephalins and/or their fragments in medical diagnostics: The invention relates to the diagnosis of disease based on the presence of biochemical components in human or animal body fluids, tissues and/or biomaterials. More specifically the invention relates to the use of precursors of enkephalins and/or its fragments isolated from body fluids, tissues or other biomaterials as a marker... Agent: Heslin Rothenberg Farley & Mesiti PC

20080261237 - Inositol-phosphate derivatives and method of detecting inositol-1-phosphate: e

20080261242 - Highly sensitive system and methods for analysis of troponin: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.... Agent: Wilson Sonsini Goodrich & Rosati

20080261245 - Antibodies, including fv molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use: Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to anti-mesothelin... Agent: Townsend And Townsend And Crew, LLP

20080261244 - Compositions and methods for treating and diagnosing pancreatic cancer: The present invention relates to the field of oncology and provides novel compositions and methods for diagnosing and treating pancreatic cancer. In particular, the present invention provides pancreatic cancer stem cells useful for the study, diagnosis, and treatment of solid tumors.... Agent: Casimir Jones, S.c.

20080261243 - Detection of elevated levels of her-2/neu protein on circulating cancer cells and treatment: The expression of Her-2/neu protein on circulating cancer cells in a blood sample is detected by isolating the cancer cells from the blood sample and then performing on the isolated cancer cells a sensitive Her-2/neu immunoassay. A positive result indicates the expression of Her-2/neu on cancer cells in the blood... Agent: Wellstat Management Company. LLC

20080261246 - Tissue inhibitor of matrix metalloproteinases type-1 (timp-1) as a cancer marker and postoperative marker for minimal residual disease or recurrent disease in patients with a prior history of cancer: The present invention describes a method for determining whether an individual is suffering from cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual. The present invention furthermore describes a method for determining whether an individual is suffering from minimal residual disease or recurrent... Agent: Roberts Mlotkowski Safran & Cole, P.C. Intellectual Property Department

20080261247 - Method of detecting red cell antigen-antibody reactions: e

20080261248 - Method of detecting red cell antigen-antibody reactions:

20080261239 - Detecting molecular interactions: The present disclosure features a variety of compositions, kits, and methods that are useful for, inter alia, detecting and/or analyzing an interaction between two molecules, a target molecule and a target-specific binding agent which can be, e.g., proteins, nucleic acids, saccharides or polysaccharides, small molecules, or combinations of any of... Agent: Fish & Richardson PC

20080261240 - Method: A method for attenuating a microorganism which comprises inhibiting in the microorganism a metabolic pathway essential for viability, by promoting use of the substrate of the pathway in a different metabolic pathway which is non-essential to the microorganism whereby the substrate is unavailable to the essential pathway and the micro... Agent: Astrazeneca R&d Boston

20080261238 - Method for differentiation of factor xiii deficiency states in relation to fibrinogen deficiency states using thrombelastographic techniques: The invention relates to a method for determining a factor XIII deficiency, a method for determining a fibrinogen deficiency, and a method for differentiating between a factor XIII deficiency and a fibrinogen deficiency by means of thrombelastographic techniques. On the basis of the evaluation of the thrombelastographic parameters, a rapid... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080261241 - Targeted ubiquitination of proteins and screening methods using a new class of ubiquitin ligase proteins: Members of the IpaH superfamily constitute a novel class of E3 ubiquitin ligases which are useful for engineering products which modulate trafficking and destruction of target proteins inside a cell and useful targets for identifying new antimicrobial molecules which modulate, especially inhibit, E3 ligases.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080261249 - Detecting and quantifying host cell proteins in recombinant protein products: A single-step immunoassay method, kit, and reagents for detecting and quantifying contaminant host cell proteins in a recombinant protein sample are described. The method includes the step of adding to immobilized medium comprising a capture reagent including anti-host cell protein antibodies, both the recombinant protein sample and a detection reagent... Agent: Nikolaos C. George Jones Day

20080261250 - Methods for assessing the risk for development of cardiovascular disease: The present invention relates to diagnostic tests, methods and kits that are useful to assess a subject's risk of developing a pathologic condition related in part to the presence of HDL oxidation product. Measuring the quantity of one or more HDL oxidation products present in the blood is useful in... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20080261251 - Monoclonal antibodies, hybridomas, improved method for determining the protein ptx3 and kit for said determination: Method for determining the level of PTX3 protein in a sample of a biological fluid; hybridoma capable of producing a rat anti-PTX3 monoclonal antibody where said hybridoma is selected from the group comprising MNB10 and Pen-3; specific anti-PTX3 rat monoclonal antibody selected from the monoclonal antibodies produced by the hybridomas... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080261252 - Soluble interleukin-1 receptor accessory molecule: The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20080261253 - Methods and kits for the diagnosis of galactosemia: Provided are methods for the detection and diagnosis of galactosemia. The methods are based on the discovery that abnormal levels of selected analytes in sample fluid, typically blood samples, of patients who are at risk are supportive of a diagnosis of galactosemia. At least two new biomarkers for galactosemia are... Agent: Foley And Lardner LLP Suite 500

20080261254 - Procedure for the determination of the reaction lag phase in an analyte-dependent reaction: The invention is in the field of analytical technique and relates to an improved procedure for determining the concentration or activity of an analyte, an analyte-dependent detection reaction being set in motion and the reaction kinetics determined being evaluated. The procedure makes possible an individual determination of the lag phase... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080261256 - Methods of assaying receptor activity and constructs useful in such methods: Described are methods of detecting G-protein coupled receptor (GPCR) activity in vivo and in vitro; methods of assaying GPCR activity; and methods of screening for GPCR ligands, G protein-coupled receptor kinase (GRK) activity, and compounds that interact with components of the GPCR regulatory process. Constructs useful in such methods are... Agent: Morgan, Lewis & Bockius, LLP

20080261255 - Proteins, sensors, and methods of characterizing analytes using the same: A protein sensing molecule is capable of binding an analyte in a sample. The protein sensing molecule includes a first detectable quality that changes in a concentration dependent manner when the protein sensing molecule is bound to the analyte. The protein sensing molecule also includes a second detectable quality that... Agent: Rene A. Vazquez Williams Mullen

20080261259 - Culture media for expansion and differentiation of epidermal cells and uses thereof for in vitro growth of hair follicles: The invention is directed to a chemically defined animal cell culture media, and methods for preparing such a medium, wherein the media are suitable for culturing epidermal cells, preferably human epidermal cells, including cells of the hair follicle. The invention further provides for methods of culturing epidermal cells, hair follicles,... Agent: Wilmerhale/columbia University

20080261257 - Fluorescent proteins and related methods and compounds: The invention includes fusion polypeptides including a first fluorescent protein, e.g., a FRET donor protein, a second fluorescent protein, e.g., a FRET acceptor protein, and, linked to at least one of the fluorescent (e.g., FRET donor or FRET acceptor) proteins, an Fc-region of an immunoglobulin. The polypeptide can be immobilized... Agent: Fish & Richardson PC

20080261258 - Immune cell biosensors and methods of using same: The present invention relates to immunological cells that are useful in detecting changes in physiological states, which provide for methods of diagnosing diseases or monitoring the course of patient therapy. Also provided are arrays of antigen presenting cell-specific markers for detecting changes in physiological states, and methods of detecting such... Agent: Foley & Lardner LLP

20080261261 - System/unit and method employing a plurality of magnetoelastic sensor elements for automatically quantifying parameters of whole blood and platelet-rich plasma: A system/analyzer-unit and method/platform—using information obtained from at least one, adapted for a plurality of, magnetoelastic sensor elements in contact with one or more samples comprising blood from a patient—for automatically quantifying one or more parameters of the patient's blood. Information obtained from emissions measured from each of the sensor... Agent: Jean M. Macheledt

20080261260 - Use of gelsolin to treat infections: The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression.... Agent: Wolf Greenfield & Sacks, P.C.

20080261262 - Lysis/resealing process and device for incorporating an active ingredient, in particular asparaginase or inositol hexaphosphate, in erythrocytes: Lysis/resealing process for preparing erythrocytes which contain an active ingredient (e.g. aspariginase or inositol hexaphosphate), the process comprising the following steps: (1) placing a globular concentrate in suspension in an isotonic solution having a haematocrit level which is equal to or greater than 65%, with refrigeration at from +1 to... Agent: Stites & Harbison PLLC

20080261263 - In vitro evaluation of micro-organisms and their antimicrobial agent susceptibilities: A method of identifying a micro-organism and determining the susceptibility of the micro-organism to an antimicrobial agent by inserting a sample of the micro-organism in a primary culture container and allowing the micro-organism to multiply. The primary culture is then divided into a plurality of secondary cultures and the metabolic... Agent: D. Peter Hochberg Co. L.p.a.

20080261264 - Culture medium for detecting of clostridium perfringens: The invention relates to a culture medium for the detection of Clostridium perfringens. The invention consists in: dissolving protease peptone, microbiological peptone, yeast extract, sodium bisulphite and ferric ammonium citrate in deonized water; sterilising said solution at 121° C. for 15 minutes and cooling same; and, subsequently, adding cycloserine and... Agent: Merchant & Gould PC

20080261265 - Histological staining composition and methods related thereto: Embodiments of the invention relate to a method for histological staining, the method comprises immersing a tissue sample in a staining solution sufficient to impregnate the tissue sample, dehydrating the tissue sample, embedding the tissue sample, cutting the tissue sample, developing the tissue sample, fixing the tissue sample and mounting... Agent: Schwegman, Lundberg & Woessner, P.A.

20080261266 - Methods and compositions for a microemulsion-based tissue treatment: The invention is directed to methods and compositions for deparaffinizing paraffin-embedded biological samples for subsequent tissue staining. The compositions are microemulsions that may include water/oil/surfactant microemulsions, and optionally a cosurfactant. The microemulsions enable deparaffinization without the use of xylene or toluene, and also enable solvent exchange without the use of... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20080261268 - 5-substituted hydantoin racemase, dna encoding the same, recombinant dna, transformed cell, and process for production of optically active n-carbamylamino acid or optically active amino acid: Disclosed are a novel hydantoin racemase and a process for producing an optically active N-carbamylamino acid or an optically active amino acid using the hydantoin racemase. A novel hydantoin racemase isolated and purified from Bacillus sp. Strain KNK519HR; a gene encoding the hydantoin racemase; a recombinant plasmid having the gene... Agent: Sughrue Mion, PLLC

20080261269 - Alleles of the oxyr gene from coryneform bacteria: The invention relates to mutants and alleles of the oxyR gene of coryneform bacteria coding for variants of the OxyR transcription regulator and processes for producing amino acids using bacteria which comprise these alleles.... Agent: Smith, Gambrell & Russell

20080261267 - Cellulases from rumen: The invention provides polypeptides coding for new cellulases from rumen, particularly from rumen ecosystem. The invention also relates to functional fragments or functional derivatives thereof as well as to nucleic acids encoding the polypeptides of the invention, vectors and host cells containing said nucleic acids, a method for producing the... Agent: Klauber & Jackson

20080261271 - Expression of hiv polypeptides and production of virus-like particles: The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation... Agent: Novartis Vaccines And Diagnostics Inc.

20080261272 - Fungal cell wall synthesis gene: A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these... Agent: Townsend And Townsend And Crew, LLP

20080261273 - Process for producing hmg-coa reductase inhibitors: r

20080261270 - Soluble erbb3 receptor isoforms: The present invention discloses a system and method using isoforms of the human ErbB3 receptor as negative regulators of heregulin-stimulated ErbB2, ErbB3, and ErbB4 activation. The present invention also discloses a system and method of one such isoform, p85-sErbB3 binding to heregulin with an affinity comparable to that of full-length... Agent: Cohen & Grigsby, P.C.

20080261274 - Restoration of cholesterol independence and its use as a selectable marker in ns0 cell culture: Gene complementation is used to restore cholesterol independence in NS lineage murine myeloma cells, such as NSO and NS 1, yielding a selectable system for recombinant production of polynucleotides and polypeptides.... Agent: Gargi Seth

20080261275 - Cdna production from cells after laser microdissection: The present invention provides a new procedure for the synthesis of CDNA from single cells after microdissection. It has the advantage that it is cost-efficient and can be carried out quickly with only few steps, even by less skilled laboratory employees. For the first time, the time-consuming and risky step... Agent: K.f. Ross P.C.

20080261276 - Micro-fluidic device based upon active matrix principles: A micro-fluidic device (1) including a two-dimensional array of a plurality of components (2) for processing a fluid and/or for sensing properties of the fluid is suggested. Each component (2) is coupled to at least one control terminal (9,10) enabling an active matrix to change the state of each component... Agent: Philips Intellectual Property & Standards

20080261277 - Prna chimera: A circularly permuted chimeric pRNA molecule carrying a stabilized biologically active RNA, such as a ribozyme.... Agent: Mueting, Raasch & Gebhardt, P.A.

20080261278 - Method for producing l-amino acid using bacteria belonging to the genus escherichia: There is provided a method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine using a bacterium belonging to the genus Escherichia wherein the L-amino acid productivity of the bacterium is enhanced by enhancing the activities of the proteins coded by the b2682 and b2683 genes, or the protein coded... Agent: Cermak & Kenealy LLP Acs LLC

20080261279 - Method for producing l-amino acid using bacteria belonging to the genus escherichia: A method for producing L-threonine, L-valine, L-proline, L-leucine, L-methionine and L-arginine is provided using Escherichia bacteria wherein the L-amino acid productivity of the bacteria is enhanced by increasing the activity of proteins encoded by the b2682 and b2683 genes, or proteins encoded by the b1242 or b3434 gene.... Agent: Cermak & Kenealy LLP Acs LLC

20080261280 - Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms: Disclosed are the uses of specific genes of the mevalonate and isoprenoid biosynthetic pathways, and of inactive gene sites (the pseudogene) to (1) enhance biosynthesis of isopentenyl diphosphate, dimethylallyl diphosphate and isoprenoid pathway derived products in the plastids of transgenic plants and microalgae, (2) create novel antibiotic resistant transgenic plants... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080261281 - Novel carbonyl reductase, gene thereof and method of using the same: s

20080261282 - Fermentation process for preparing coenzyme q10 by the recombinant agrobacterium tumefaciens: The present invention relates to a transformed Agrobacterium tumefaciens BNQ-pGPRX11 (Accession No. KCCM-10554) harboring a recombinant expression vector (pGPRX11). Further, the present invention also provides a fermentation method for maximum production of coenzyme Q10 using a transformed Agrobacterium tumefaciens deposited to Korean Culture Center of Microorganism with accession number KCCM-10554... Agent: Kenyon & Kenyon LLP

20080261283 - Biooxidation capabilities of candida sp: A bioprocess for producing carboxylic acids, alcohols and aldehydes is provided by culturing Candida sp. in a fermentation medium containing various defined substrates.... Agent: Synnestvedt & Lechner LLP

20080261284 - Method for the production of lactic acid or a salt thereof by simultaneous saccharification and fermentation of starch: The present invention pertains to a method for the production of lactic acid or a salt thereof, wherein starch is subjected to a process of simultaneous saccharification and fermentation, the method comprising saccharifying starch in a medium comprising at least a glucoamylase and simultaneously fermenting the starch using a microorganism,... Agent: Oliff & Berridge, PLC

20080261285 - Method for the production of lactic acid or a salt thereof by simultaneous saccharification and fermentation of starch: The present invention pertains to a method for the production of lactic acid or a salt thereof wherein starch is subjected to a process of simultaneous saccharification and fermentation, the method comprising saccharifying starch in a medium comprising at least a glucoamylase and simultaneously fermenting the starch using a microorganism,... Agent: Oliff & Berridge, PLC

20080261286 - Methods for producing optically active alpha-hydroxy amides: An enzyme exhibiting high stereoselectivity was purified from a number of Saccharomyces cerevisiae enzymes with 2-chlorobenzoyl formamide-reducing activity, and the biochemical properties of the purified enzyme were analyzed. The analysis of a partial internal amino acid sequence of the purified enzyme revealed that the enzyme may be encoded by the... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080261287 - Metabolic engineering of xylos fermentation: The present invention relates to further genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers the host cell the ability of isomerising xylose to xylulose. The further genetic modifications are aimed at improving the efficiency of xylose metabolism and include e.g. reduction... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080261288 - Micro-organ device: A method for fabricating a micro-organ device comprises providing a microscale support having one or more microfluidic channels and one or more micro-chambers for housing a micro-organ and printing a micro-organ on the microscale support using a cell suspension in a syringe controlled by a computer-aided tissue engineering system, wherein... Agent: Nasa Johnson Space Center

20080261289 - Compositions comprising viruses and methods for concentrating virus preparations: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.... Agent: Townsend And Townsend And Crew, LLP

20080261290 - Tetrahymena heat inducible promoters and their use: c

20080261291 - Method of obtaining cyanogenic glycoside and related glycosides, as well as genin and sapogenins derivatives of plants of the family sapotaceae for the preparation of cosmetics and dermatological compositions: Procedure for the obtaining of genin and sapogenins extracts by enzymatic hydrolysis of kernels derived of the family Sapotaceae, genus Calocarpum, Chrysophyllum and Lucuma. The enzymes that catalyzes the hydrolysis are exogenous β-glucosidases, of vegetable or microbial origin. The process uses mainly diverse kernel (seeds removed of the endocarp) derived... Agent: Hoffman Wasson & Gitler, P.c Crystal Center 2, Suite 522

20080261293 - Homogeneous method to prepare sperm dna from sexual assault cases: The present invention provides a method for the isolation of sperm DNA from swabs taken from rape victims without having to perform a change in buffers. Non-sperm cells from the victim are digested with an enzyme and solubilized, and then in the same buffer an enzyme capable of digesting soluble... Agent: Alex Garvin

20080261292 - Method enabling the use of extracellular ribonucleic acid (rna) extracted from plasma or serum to detect, monitor or evaluate cancer or premalignant conditions: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound RNA, lipid-RNA complexes, lipoprotein (proteolipid)-RNA complexes, protein-RNA... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080261294 - Apparatus for chemiluminescent assay and detection: An apparatus includes a system for guiding chemiluminescence and a system for preventing a variation in dark currents. The apparatus includes a first light shielding BOX having a sample container holder and a shutter unit therein, the shutter unit including a top plate which is partly formed by a movement... Agent: Mattingly, Stanger, Malur & Brundidge, P.C.

20080261295 - Cell sorting system and methods: Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of... Agent: O''melveny & Myers LLP Ip&t Calendar Department La-1118

20080261296 - Process challenge device for assessing the effective performance of a biocontamination deactivation process: A process challenge device (PCD) for determining the effectiveness of a microbial deactivation process that uses a vaporous deactivating agent (e.g., vaporized hydrogen peroxide) as a deactivating agent. The PCD includes first and second layers that are joined together to form (1) a chamber dimensioned to receive a biological and/or... Agent: Kusner & Jaffe Highland Place Suite 310

20080261297 - Assay device: An assay device (1) having a rotatable platform (2) with a test chamber (6) and a sensor (20) which undergoes displacement when subject to a particular substance such as a chemical, biological species or other organism. The sensor is a cantilever beam (21) with a porous section (23) to enhance... Agent: Townsend And Townsend And Crew, LLP

20080261298 - Method and device for the multiplex analysis of cells and tissues: This invention is used for the multiplex analysis method of cells or tissues by combination of multiple cubicles and permeable membrane. Utilizing the diffusion based reagents administration; cells and tissues in multiple cubicles receive signals evenly in their cubicles as parallel manner. This device makes efficient multiplex cells or tissues... Agent: Hiroyuki Yonekawa

20080261299 - Pneumatic bioreactor: A pneumatic bioreactor having a containment vessel which includes a semi-cylindrical concavity defined by the vessel bottom. A mixing apparatus includes a rotational mixer rotatably mounted within the containment vessel about a horizontal axis. The rotational mixer has buoyancy-driven mixing cavities which are fed by a gas supply beneath the... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080261300 - Synthetic genes: The invention provides strategies, methods, vectors, reagents, and systems for production of synthetic genes, production of libraries of such genes, and manipulation and characterization of the genes and corresponding encoded polypeptides. In one aspect, the synthetic genes can encode polyketide synthase polypeptides and facilitate production of therapeutically or commercially important... Agent: Townsend And Townsend And Crew, LLP

20080261301 - Antibody composition-producing cell: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for... Agent: Sughrue-265550

20080261302 - Methods of diagnosing or treating neurological diseases and cell degeneration: The invention discloses an isolated nucleic acid molecule encoding a protein molecule, the function of which is to protect cells against degeneration and/or cell death, wherein the amino acid sequence of the protein comprises the sequence shown in SEQ ID NO. 2 or a functional variant thereof.... Agent: Jacobson Holman PLLC

20080261303 - Method and medicament for inhibiting the expression of a given gene: The present invention relates to the specific inhibition of expression of a target gene in mammals using a short double stranded RNA. The dsRNA is less than 49 nucleotides in length and has a nucleotide sequence which is complementary to at least a part of the target gene. The dsRNAs... Agent: Lowrie, Lando & Anastasi, LLP A2038

20080261304 - Methods and compositions for enhancing delivery of double-stranded rna or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells: A double-stranded RNA, preferably a small, interfering (si)RNA or a siHybrid, to which cholesterol moieties are linked.... Agent: Nastech Pharmaceutical Company Inc

20080261305 - Tgf-beta-mediated osteogenic differentiation of mesenchymal stem cells: Methods and compositions are provided for the culture of MSC to provide osteogenic progenitor cells.... Agent: Bozicevic, Field & Francis LLP Stanford University Office Of Technology Licensing

20080261306 - Method for creating perfusable microvessel systems: A method for creating networks of perfusable microvessels in vitro. A mandrel is drawn through a matrix to form a channel through the matrix. Cells are injected into the channel. The matrix is incubated to allow the cells to attach inside the channel. The channel is perfused to remove unattached... Agent: George A Leone, Sr Citadel Patent Law

20080261307 - Method of isolating and proliferating autologous antigen-specific cd8+ t cell using anti-4-1bb antibodies: Provided are methods of isolating and proliferating antigen-specific CD8+ T cells using anti-4-1BB antibodies. The methods of isolating and proliferating CD8+ T cells may yield cells at a higher recovery rate than a conventional isolation method, and the isolation method using humanized anti-4-1BB antibodies may also yield cells at a... Agent: Reed Smith LLP Suite 1400

20080261308 - Dry powder cell culture products and methods of production thereof: The present invention relates to nutritive medium, medium supplement, media subgroup and buffer formulations. The present invention provides powder nutritive medium, medium supplement and medium subgroup formulations, e.g., cell culture medium supplements (including powdered sera such as powdered fetal bovine serum (FBS)), medium subgroup formulations and cell culture media comprising... Agent: Invitrogen Corporation C/o Intellevate

20080261309 - In vitro multiplication of hoodia plants: A tissue culture micropropagation process for Hoodia plants, which achieves new shoots in the multiplication stage of the process by using an inventive combination of phytohormones.... Agent: Unilever Patent Group

20080261310 - In vitro rooting of hoodia plants: An in vitro tissue culture process of rooting Hoodia explants by using an inventive combination of phytohormones.... Agent: Unilever Patent Group

20080261311 - In vivo incorporation of unnatural amino acids: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.... Agent: Quine Intellectual Property Law Group, P.C.

20080254439 - Plant extract and use thereof as a cryoprotective agent: A cryopreservation medium comprising a protein-containing plant extract is disclosed. Methods, compositions, uses and kits for cryopreservation of biological material, such as a molecule, organelle, cell, embryo, tissue or organ, are also disclosed.... Agent: Goudreau Gage Dubuc

20080254440 - Anti-sars virus antibody, hybridoma producing the antibody and immunoassay reagent using the antibody: A monoclonal antibody which specifically recognizes SARS virus is provided, and an immunoassay, immunoassay reagent and immunoassay device for detecting the SARS virus using the monoclonal antibody are disclosed. The monoclonal antibody according to the present invention is a monoclonal antibody against a nucleoprotein of a corona virus causing severe... Agent: Birch Stewart Kolasch & Birch

20080254442 - Crystal structures of human peptide deformylase: The present invention provides the three-dimensional structure of human mitochondrial Homo sapiens peptide deformylase (HsPDF) protein, and HsPDF complexed to a binding compound, such as a PDF inhibitor. This crystallographic information will aid in the identification and development of novel binding compounds of HsPDF and other PDF family members which... Agent: Choate, Hall & Stewart LLP Sloan-kettering Institute For Cancer Research

20080254444 - Immunoassay devices and use thereof: An immunoassay device has a housing defining a first opening for receiving a solution and a second opening through which a liquid sample is deposited, a strip of sorbent material having a test site with immobilized antigen or antibody for the ligand to be tested, and a filter for filtering... Agent: Gordon & Jacobson, P.C.

20080254441 - Lateral-flow test device providing improved test result validity: The present invention refers to a lateral-flow test device providing improved test result validity comprising at least one indication means indicating whether a test result will be inconclusive and/or at least one indication means indicating that a test result is ready for read. It is further referred to a use... Agent: Schmeiser, Olsen & Watts

20080254443 - Norovirus detection, methods and compositions therefor: A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a... Agent: Sonnenschein Nath & Rosenthal LLP

20080254476 - il-1 gene cluster and associated inflammatory polymorphisms and haplotypes: The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080254477 - il-1 gene cluster and associated inflammatory polymorphisms and haplotypes: The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080254462 - Altered zdhhc8 expression as a marker of increased risk of schizophrenia: The present invention relates to the role of mutations that perturb expression of ZDHHC8 in increased susceptibility to schizophrenia. It is based, at least in part, on the discovery of a mechanism by which a high risk allele disrupts expression of functional ZDHHC 8, and on the discovery that two... Agent: Baker Botts L.L.P.

20080254448 - Analysis chip with reference range, kits and methods of analysis: Analysis chip of at least one analyte, said chip comprising at least one analysis spot for recognition and immobilization specific to the analyte; and a reference range (G) comprising several reference spots each arranged on said chip in a defined manner and independently of one another, each reference spot of... Agent: Mckenna Long & Aldridge LLP

20080254453 - Analysis of methylation using selective adaptor ligation: Methods of analyzing DNA to identify regions of the genome that are methylated in a genomic sample are disclosed. In one aspect genomic DNA is fragmented using a restriction enzyme with a degenerate recognition site, methylated restriction fragments are separated from unmethylated fragments by affinity purification. The complexity of the... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20080254471 - Apparatus and method for microbial and forensic sampling and manipulation: The present invention provides a sterile collection package and methods for sample procurement and manipulation including microbial and forensic testing. The collection package comprises a tissue or sample collection container with a sealable opening, at least one drain container, and at least one tubing set that connects the tissue or... Agent: Wong, Cabello, Lutsch, Rutherford & Brucculeri, L.L.P.

20080254465 - Assays for measuring nucleic acid binding proteins and enzyme activities: Processes for measuring DNA or RNA binding proteins, specific nucleic acids, as well as enzyme activities using labeled nucleic acids of labeled protein/peptide molecules are provided.... Agent: Foley & Lardner LLP

20080254467 - Automated high-throughput flow-through real-time diagnostic system: An automated real-time flow-through system capable of processing multiple samples in an asynchronous, simultaneous, and parallel fashion for nucleic acid extraction and purification, followed by assay assembly, genetic amplification, multiplex detection, analysis, and decontamination. The system is able to hold and access an unlimited number of fluorescent reagents that may... Agent: Lawrence Livermore National Security, LLC

20080254451 - Compositions and methods for treating schizophrenia and related disorders: The present invention relates, generally, to methods and compositions for detecting or treating mental disorders, such as schizophrenia. The present invention more particularly discloses the identification of human genes which can be used for the diagnosis, prevention and treatment of schizophrenia and related disorders, as well as for the screening... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080254455 - Detecting prostate cancer: Methods and kits for detecting prostate cancer in urine samples include detecting the methylation status of various genes.... Agent: Philip S. Johnson Johnson & Johnson

20080254463 - Detection method for differentiating between chicken-derived ingredients and egg-derived ingredients in products: The present invention relates to a detection method to differentiate between egg-derived ingredients and chicken-derived ingredients (chicken parts/tissues, excluding eggs) in foods or other products and primer pairs and probes used for specifically detecting chicken in foods or products.... Agent: Wpat, PC Intellectual Property Attorneys

20080254474 - Dna methylation analysis by digital bisulfite genomic sequencing and digital methylight: Provided are novel sensitive methylation assays referred to herein as Digital MethyLight, comprising stochastically distributing and compartmentalizing bisulfite-treated genomic DNA over multiple PCR reaction wells for detection of individually methylated DNA molecules in a large background of unmethylated DNA. Digital Bisulfite Genomic DNA Sequencing methods are also provided for high-resolution... Agent: Davis Wright Tremaine, LLP/seattle

20080254456 - Gene marker for human hepatocellular carcinoma diagnosis: The present invention relates to a gene marker for diagnosis of human hepatocellular carcinoma (HCC), which is selected from the group consisting of IGF2, VEGF, MET, SUMO2, CDK4, MMP9, PLK1, AFP, Rb1, CYP3A4, LAP3, RIZ, DLC1, ITIH1, FetB, ALDOB, SULT2A1, ASS, HP, SERIND1, EI24, HGD, RODH, F2, SORD, and KNG.... Agent: Birch Stewart Kolasch & Birch

20080254454 - Genetic markers for assessing risk of premature birth resulting from preterm premature rupture of membranes: A method to identify women who are at risk for preterm delivery due to premature rupture of membranes (PPROM) is provided. The method entails detecting the presence of SERPINH1 gene variants that express low levels of the gene product, heat shock protein Hsp47. The occurrence of a T (rather than... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20080254466 - Heregulin-like factor: The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20080254450 - Human obesity susceptibility genes encoding peptide hormones and uses thereof: The present invention discloses the identification of human obesity susceptibility genes, which can be used for the diagnosis and prevention of obesity and related disorders. The invention more specifically discloses that the PPY and PYY gene on chromosome 17 and certain alleles thereof are related to susceptibility to obesity. The... Agent: Fish & Richardson PC

20080254464 - Identification of genetic markers of biological age and metabolism: A method of measuring the biological age of a multicellular organism is disclosed. In one embodiment this method comprises the steps of obtaining a sample of nucleic acid isolated from the organism's organ, tissue or cell and determining the expression pattern of a panel of sequences within the nucleic acid... Agent: Jean C. Baker, Esq. Quarles & Brady LLP

20080254478 - Il-gene cluster and associated inflammatory polymorphisms and haplotypes: The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080254447 - Method and nucleic acids for the improved treatment of breast cell proliferative disorders: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine... Agent: Davis Wright Tremaine, LLP/seattle

20080254472 - Method for detecting nucleic acid in sample, method for designing probes, system for designing probes therefor: Accurate detection of a target microorganism from a sample, which may contain a plurality of microorganisms, is intended. This can be realized by eliminating a possibility of cross-hybridization of a microorganism with other probes, which can accelerate the designing speed, detecting microorganisms one-by-one in the designed order, and absorbing all... Agent: Fitzpatrick Cella Harper & Scinto

20080254469 - Method for regenerating hydrophilic and osteophilic surface of an implant: Described herein are methods for testing an aged surface on an implant, methods for regenerating a hydrophilic and osteophilic surface on the implant and kits therefor.... Agent: Squire, Sanders & Dempsey L.L.P.

20080254446 - Method of detecting target molecule by using aptamer: An aptamer-probe complex for detecting the presence of a target molecule is disclosed. The complex of the present invention contains an aptamer moiety which is able to bind to an indicator protein and change the properties of the indicator protein, and a probe moiety which is able to bind to... Agent: Birch Stewart Kolasch & Birch

20080254460 - Method of fetal cell enrichment: The present invention provides a method of enriching fetal cells in a maternal blood sample wherein cells which are CD34+ and capable of adhering to a solid support are selected, an analysable sample of fetal cells obtainable by the methods of the invention and a kit for use in the... Agent: Knobbe Martens Olson & Bear LLP

20080254458 - Method of pre-treating in pleural effusion for detection of mycobacterium tuberculosis: e

20080254459 - Methods and biomarkers for detecting nanoparticle exposure: Methods for gene expression profiling for exposure to nanoscale particulates or nanomaterials is provided together with identified biomarkers for nanomaterial exposure. A toxicogenomic exposure profile for nanomaterial contact is provided in accordance with a systems biology approach by iteratively sampling a test system several times after contact with nanomaterials of... Agent: Wong, Cabello, Lutsch, Rutherford & Brucculeri, L.L.P.

20080254470 - Methods and nucleic acids for the analysis of gene expression associated with the prognosis of cell proliferative disorders: The present application provides methods and nucleic acids for providing a prognosis of cell proliferative disorders, most preferably cancer but not breast cancer.... Agent: Davis Wright Tremaine, LLP/seattle

20080254457 - Methods for evaluating drug-resistance gene expression in the cancer patient: The methods of the invention detect in a qualitative or quantitative fashion drug-resistance RNA and DNA in blood plasma, serum, and other bodily fluids. The methods of the invention thereby enable the assessment of drug resistance in a neoplasm without the requirement of a tissue biopsy. The inventive methods are... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080254461 - Methods for isolating and characterizing endogenous mrna-protein (mrnp) complexes: Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex and include cell cultures, cell extracts, and whole tissue, including tumor... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080254468 - Micro-fluidic temperature driven valve: Subject of the present invention is a micro-fluidic device for the use in an apparatus for analyzing a liquid sample by nucleic acid amplification, an apparatus for analyzing a liquid sample by nucleic acid amplification, a method for analyzing a liquid sample and a method for amplifying nucleic acids in... Agent: Roche Molecular Systems, Inc. Patent Law Department

20080254475 - Nematodes as model organisms for the investigation of neurodegenerative diseases, in particular parkinsons disease, uses and methods for the discovery of substances and genes which can used in the treatment of the above disease states and identification o: The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases, in particular, Parkinsons disease, uses and methods for the discovery of substances and genes which can be used in the treatment of the above disease states and identification of a nematode gene, From C elegans, which... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080254452 - Pkp3 oncogene as a prognostic indicator for lung cancer: The present invention provides the method of predicting an non-small cell lung cancer (NSCLC) prognosis.... Agent: Townsend And Townsend And Crew, LLP

20080254449 - Polynucleotides for the detection of escherichia coli 0157: Polynucleotide primers and probes for the amplification and detection of E. coli O157 in a test sample are provided. The primers and probes can be used in real time diagnostic assays for rapid detection of E. coli O157 in a variety of situations, including clinical samples, microbiological pure cultures, food,... Agent: K&l Gates LLP

20080254473 - Predicting post-treatment survival in cancer patients with micrornas: This invention provides a method for predicting the post-treatment survival prospect of a cancer patient based on the expression level(s) of microRNAs hsa-miR137, hsa-miR372, hsa-miR182*, hsa-miR221, and hsa-let-7a in that cancer patient.... Agent: Occhiuti Rohlicek & Tsao, LLP

20080254445 - Prognosis in cancer patients vaccinated with a cancer antigen peptide-associated agent: The correlation of clinical benefits and immune responses to peptides in cancer patients who were vaccinated with CTL-directed peptides is shown. The invention relates to a process for determining prognosis in a cancer patient vaccinated with a cancer antigen peptide-associated agent, which comprises measuring a level of an antibody specific... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080254482 - Autoimmune disease biomarkers: Provided herein are novel panels of biomarkers for the diagnosis of autoimmune diseases, and methods and kits for detecting these biomarkers in samples of individuals suspected of having an autoimmune disease. Also provided are methods of monitoring the progression of an autoimmune disease and methods of monitoring the efficacy and... Agent: Greenlee Winner And Sullivan P C

20080254483 - In vitro method for diagnosing and monitoring renal cell carcinoma (rcc) using mmp-7 as humoral biomarker for rcc: The present invention relates to the use of matrix metalloproteinase 7 (MMP-7) and/or its precursors and fragments with MMP-7 immunoreactivity, or of circulating anti-MMP-7 antibodies, as humoral biomarkers in diagnostic in vitro methods for the detection, early detection, monitoring and/or prognosis of renal cell carcinoma (RCC) in human patients.... Agent: Heslin Rothenberg Farley & Mesiti PC

20080254481 - Methods and kits for detecting prostate cancer biomarkers: Provided herein are novel autoantibody biomarkers, and panels for detecting autoantibody biomarkers for prostate cancer, and methods and kits for detecting these biomarkers in the serum of individuals suspected of having prostate cancer.... Agent: Greenlee Winner And Sullivan P C

20080254479 - Methods and kits for predicting risk for preterm labor: The invention is directed to kits and methods that allow one to predict the risk for preterm labor in a pregnant woman. The inventors have discovered that various extracellular matrix components can be detected in cervical secretions. The quantification of certain extracellular matrix proteins found within cervical secretions can be... Agent: Sonnenschein Nath & Rosenthal LLP

20080254480 - Microcytoxicity assay by pre-labeling target cells: The standard or original microcytotoxicity assay (OMCA) has significant advantages over other cytotoxicity assays, since it is able to detect both cell necrosis and apoptosis and it is simpler, safer, more practical, and more economical. OMCA has serious weaknesses, however, such as low accuracy, low selectivity, and low sensitivity. These... Agent: Foley And Lardner LLP Suite 500

20080254484 - Preparation of deallergenized proteins and permuteins: e

20080254487 - Connective tissue growth factor signaling: The present invention provides compounds and agents that modulate CTGF-mediated cell adhesion and/or binding of CTGF to cells. The invention further provides assays that may be used to identify additional modulators of CTGF-mediated cell adhesion and CTGF binding to cells, and assays that may be used to identify compounds or... Agent: Fibrogen, Inc. Intellectual Property Department

20080254488 - Cancer test: The CD133 marker has been found to be diagnostic of malignant lung cancers. Tests and kits to show such cells and uses for such cells are disclosed.... Agent: Greenlee Winner And Sullivan P C

20080254489 - Methods and compositions for risk stratification: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in... Agent: Bozicevic, Field & Francis LLP Stanford University Office Of Technology Licensing

20080254485 - Methods and compositions for monitoring and risk prediction in cardiorenal syndrome: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to monitor cardiorenal syndrome using assays that detect NGAL, preferably together with assays that detect natriuretic peptides such as BNP. Such... Agent: Inverness Medical Innovations / Wsgr Wilson Sonsini Goodrich & Rosati, P.C.

20080254486 - Prion sensors for diagnosis of transmissible spongiform encephalopathy or for detection of prions, and use thereof: Disclosed are prion sensors that may be used as a diagnostic tool to diagnose TSE, or to detect PrPSc molecules, in biological and environmental samples, and methods for using these sensors. The prion sensor may comprise an acoustic sensor, such as a TSM sensor, coated with PrPC molecules, whose resonance... Agent: Bennett Jones C/o Ms Roseann Caldwell

20080254490 - Salivary protease assays for identifying increased risk of preterm delivery induced by premature rupture of fetal membranes: Assay methods for identifying an increased risk of preterm delivery induced by premature rupture of the fetal membranes are provided. More specifically, the invention provides salivary protease assays indicative of amniochorion and fetal membrane concentrations of proteases involved in the degradation of the fetal membranes leading to rupture. An increase... Agent: Law Office Of Kenneth K. Sharples

20080254491 - Method and device for monitoring aspirin response: The invention provides a method of monitoring the response of platelets to a COX1 inhibitor such as aspirin. The method involves collecting platelet-containing mammalian blood treated with a COX 1 inhibitor; mixing the blood with a COX 1-dependent platelet agonist, such as arachidonic acid, monitoring extracellular ATP in the agonist-activated... Agent: Millen, White, Zelano & Branigan, P.C.

20080254492 - Immunoassay method, reagent kit for detecting alkaline phosphatase, and reagent kit for immunoassay: e

20080254494 - Assays for measuring nucleic acid binding proteins and enzyme activities: Processes for measuring DNA or RNA binding proteins, specific nucleic acids, as well as enzyme activities using labeled nucleic acids of labeled protein/peptide molecules are provided.... Agent: Foley & Lardner LLP

20080254493 - Screening method identifying protease secretion-deficient mutants of microorganisms: o

20080254495 - Method of diagnosing apoplectic stroke/asymptomatic brain infarction using polyamine and acrolein contents, polyamine oxidase activity or protein content thereof as indication: The present invention provides a diagnostic method for stroke/asymptomatic cerebral infarction and a screening method for patients with stroke/asymptomatic cerebral infarction, which comprise measuring acrolein content or polyamine content; or polyamine oxidase activity or protein content of polyamine oxidase in plasma. The knowledge of the present invention indicates the possibility... Agent: Greenberg Traurig LLP (la)

20080254496 - Methods for detection of fungal disease: The present invention describes the use of enzymes having D-arabinitol oxidase activity with the concomitant generation of hydrogen peroxide for the diagnosis of fungal infections of humans and other organisms, and for the detection of fungal organisms that are present on or in surfaces or permeable materials. The present invention... Agent: Passe' Intellectual Property, LLC

20080254498 - Fluorescent ion indicators and their applications: Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations.... Agent: Kolisch Hartwell, P.C.

20080254499 - Multiphoton in vivo flow cytometry method and device: u

20080254497 - Response predictors for erbb pathway-specific drugs: The invention provides a method of determining whether tumor cells or tissue is responsive to treatment with an ErbB pathway-specific drug. In accordance with the invention, measurements are made on such cells or tissues to determine values for total ErbB receptors of one or more types, ErbB receptor dimers of... Agent: Monogram/fenwick

20080254500 - Microorganism-collecting chip, microorganism-collecting kit, method of quantifying microorganisms, specimen for confirming normal state of microorganism-quantifying apparatus and microorganism-quantifying apparatus: A microorganism-collecting chip of the invention basically comprises a filter for removing contaminants and a filter for trapping microorganisms. A microorganism-collecting kit comprises the foregoing microorganism-collecting chip and a suction filtration unit. The suction filtration unit is, for example, a negative pressure tube provided at an opening with a rubber... Agent: Kratz, Quintos & Hanson, LLP

20080254501 - Chemical probe compounds that become fluorescent upon reduction, and methods for their use: Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including... Agent: Invitrogen Corporation C/o Intellevate

20080254502 - Method and apparatus for detection of bioaerosols: A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with... Agent: Francis A. Cooch, Office Of Patent Counsel The Johns Hopkins University

20080254504 - Method and apparatus for handling tissue samples: A tissue handling apparatus is provided comprising a support and a locator, for processing and embedding tissue samples. The support and cover form a chamber, within which a tissue sample is oriented prior to processing. After processing, the tissue sample within the chamber is embedded and the locator is removed,... Agent: Banner & Witcoff, Ltd.

20080254503 - Method and system for use of treatment liquids in an apparatus for staining of tissue specimens on microscope slides: A method and a system for use of treatment liquids in an apparatus for staining of tissue specimens on microscope slides, wherein the apparatus comprises a plurality of vessels (4) for receiving different liquids for treatment of the tissue specimens, a plurality of tanks (11) for treatment liquids, connecting lines... Agent: Frommer Lawrence & Haug

20080254505 - Whey protein hydrolysate: The present invention relates to a method of producing a whey protein hydrolysate using a microbial endopeptidase which specifically cleaves on the carboxy terminal side of arginine or lysine. The invention also relates to use of such whey protein hydrolysate in sports drinks or in clinical nutrition.... Agent: Novozymes North America, Inc.

20080254507 - Anti-hiv drug, polypeptide constituting the same, gene encoding the polypeptide and method of producing the anti-hiv drug: It is intended to provide an anti-HIV drug characterized by containing multimeric actinohivin, a polypeptide which is multimeric actinohivin; a gene encoding the same; and a method of producing the anti-HIV drug. The anti-HIV drug inhibits the synctium formation and has an enhanced effect... Agent: Sughrue Mion, PLLC

20080254506 - Claudin polypeptides: This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify compounds that alter Claudin polypeptide activities.... Agent: Immunex Corporation Law Department

20080254510 - Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto: In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or... Agent: Mcdermott, Will & Emery

20080254509 - Nucleotidyl transferases with enhanced nucleotide triphosphate flexibility: The present invention provides mutant Rm1A enzymes possessing an increased purine/pyrimidine bias in nucleotide triphosphate substrate specificity as compared to a corresponding non-mutated Rm1A enzyme. Such enzymes expand the types of substrates that can be used in enzymatic glycorandomization methods thereby increasing diversity of chemical libraries.... Agent: Quarles & Brady LLP

20080254508 - Type i polyketide synthase extender units: Novel extender units for Type I polyketide synthases are provided. Also provided are genes, compounds, and methods for generating these units, and for incorporation of the novel extender units into polyketides for the purpose of generating new structural derivatives of polyketide-containing products.... Agent: Brinks Hofer Gilson & Lione

20080254511 - Process for the fermentative production of proteins: The present invention relates to a process for producing a heterologous protein by means of an E. coli strain in a fermentation medium. The process comprises fermenting an E. coli strain in a fermentation medium. The E. coli strain has a mutation in the lpp gene or in the promoter... Agent: Brooks Kushman P.C.

20080254512 - Hybrid immunoglobulins with moving parts: Hybrid immunoglobulins containing moving parts are provided as well as related compositions and methods of use and methods of production. In addition, analogous genetic devices are provided as well as related compositions and methods of use and methods of production.... Agent: Cooper & Dunham, LLP

20080254513 - Cell culture medium: The invention relates to nutrient media, in particular cell culture media, which contain at least one substance selected from the group comprising citric acid, succinic acid, malic acid, α-keto-glutaric acid, fumaric acid, oxalacetic acid, isocitric acid, oxalosuccinic acid, tartaric acid, lactic acid, adipic acid and mixtures thereof and salts, derivatives... Agent: Ostrolenk Faber Gerb & Soffen

20080254515 - Fermentative production of organic compounds: The invention relates to a method for producing at least one organic compound comprising at least 3 C-atoms or at least 2 C-atoms and at least 1 N-atom by fermentation. Said method comprises the following steps: i) a starch source is ground in order to obtain a grinding material which... Agent: Connolly Bove Lodge & Hutz LLP

20080254514 - Production of a polypeptide in a serum-free cell culture liquid containing plant protein hydrolysate: The invention concerns a method for large-scale production of a polypeptide in eukaryote cells contained in a serum-free culture liquid, said method comprising (i) a propagation phase for said cells, where the cells are propagated in a first cell culture liquid, and (ii) a production phase for said cells, where... Agent: Novo Nordisk, Inc. Intellectual Property Department

20080254516 - Method of isolating nucleic acid targets: The invention provides efficient methods of isolating specific nucleic acid targets to obtain information from target nucleic acid sequences in a relatively short time period. DNA or cDNA is enzymatically digested into smaller fragments, double-stranded DNA linkers are added onto the ends of the DNA fragments to flank each fragment... Agent: Sheridan Ross PC

20080254517 - Thermal cycler with optimized sample holder geometry: The invention concerns a thermal cycler and a microtiter plate. The cycler comprises a sample holder having a first surface and a surface and means for automated, controlled heating and cooling of the sample holder. The first surface of the sample holder is designed to hold a plurality of samples... Agent: Birch Stewart Kolasch & Birch

20080254518 - Liquefaction processes: The present invention relates to method of liquefying starch-containing material, wherein the method is carried out in stages. The invention also relates to a process of producing ethanol comprising a liquefaction step carried out according to the liquefaction method of the invention.... Agent: Novozymes North America, Inc.

20080254520 - Method for reducing impurity level in mycophenolic acid fermentation: The present invention relates to methods for reducing impurities of mycophenolic acid during fermentation by controlling the level of carbon source during fermentation of mycophenolic acid and for the isolation and use as a standard marker of the impurity homo-mycophenolic acid.... Agent: Kenyon & Kenyon LLP

20080254519 - Process for producing picolinic acid compounds: wherein, H1 is an optionally substituted heterocyclic group, A1 is a single bond or an optionally substituted C1-4 alkylene group or alkenylene group, P2 is an optionally substituted phenyl group, and C1 is an optionally substituted cyclic hydrocarbon group (excluding a phenyl group), and where formula II does not represent... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080254521 - Delta-8 desaturases and their use in making polyunsaturated fatty acids: The present invention relates to Δ8 desaturase genes, which have the ability to convert eicosadienoic acid (EDA; 20:2 ω-6) to dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) and/or eicosatrienoic acid (ETrA; 20:3 ω-3) to eicosatetraenoic acid (ETA; (20:3 ω-3). Isolated nucleic acid fragments and recombinant DNA constructs comprising such fragments encoding Δ8... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080254522 - Delta-9 elongases and their use in making polyunsaturated fatty acids: The present invention relates to Δ9 elongases, which have the ability to convert linoleic acid (LA; 18:2 ω-6) to eicosadienoic acid (EDA; 20:2 ω-6) and/or α-linolenic acid (ALA; 18:3 ω-3) to eicosatrienoic acid (ETrA; 20:3 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ9 elongases along... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080254523 - Methods for the production of products in host cells: The invention provides methods and host cells for the production of ascorbic acid intermediates. The invention also provides host cells having a modification in a polynucleotide that uncouples the catabolic pathway from the oxidative pathway by deleting the encoding for an endogenous enzymatic activity that phosphorylates D-glucose at its 6th... Agent: Genencor International, Inc. Attention: Legal Department

20080254524 - Increased ethanol production from xylose: Methods and compositions for the production of ethanol from lignocellulosic starting materials are provided herein. Embodiments of the invention provide methods of manipulating the carbon flux of a host cell transformed with plasmids of the invention. Plasmids of the invention may include nucleotides that encode pyruvate decarboxylase. In one embodiment,... Agent: Buchanan Ingersoll PC (archer Daniels Midland Company)

20080254525 - Dna polymerase blends and mutant dna polymerases: A thermostable DNA polymerase composition comprising at least two DNA polymerases, one of which is substantially reduced in 5′-exonuclease activity and one of which has 5′-exonuclease activity. This polymerase may be used in methods including, but not limited to, nucleic acid synthesis, DNA sequencing, nucleic acid amplification and cDNA synthesis,... Agent: Invitrogen Corporation C/o Intellevate

20080254526 - Mutated xylanase gene with a broad ph range of reaction and site-specific mutagenesis method thereof: A mutated xylanase gene with a broad pH range of reaction includes a forty-first amino acid or a twenty-first amino acid generated from transforming asparagine to aspartic acid so as to form the mutated xylanase gene. A site-specific mutagenesis method includes the step of: mutating the forty-first amino acid or... Agent: Kamrath & Associates P.A.

20080254527 - Von willebrand factor (vwf) - cleaving protease: This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partial sequence, and more preferably comprises a polypeptide chain... Agent: Foley And Lardner LLP Suite 500

20080254528 - Baculovirus expression system: Described herein are baculovirus vectors, host cells containing the baculovirus vectors, methods of using the baculovirus vectors for cloning genes, and kits containing the baculovirus vectors.... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20080254529 - Biomass cultivation system and corresponding method of operation: A liquid culture medium containing photosynthetic organisms dispenses from a droplet generator combined with a screen in the presence of light, and in the presence of a gaseous medium to form a liquid culture medium gas-enriched with the gaseous medium. Specifically, the droplets exiting the droplet generator entrain the gaseous... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080254530 - Isolation and characterization of a single mitochondrion: A system for identifying mitochondrial heteroplasmy within eukaryotic cells is provided. This system includes means for isolating and capturing a single mitochondrion from at least one eukaryotic cell, wherein the means for isolating and capturing a single mitochondrion further includes optical tweezers or a similar optical technology; means for analyzing... Agent: Mcnees Wallace & Nurick LLC

20080254531 - Apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy: A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20080254532 - Thermal cycler with optical detector: A reaction vessel having a reaction chamber for holding a sample is fabricated by producing a housing having a rigid frame defining the minor walls of the chamber. The housing also defines a port for introducing fluid into the chamber. At least one sheet or film is attached to the... Agent: Townsend And Townsend And Crew, LLP

20080254533 - Cell expansion system and methods of use: Cell expansion systems are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second fluid flow paths associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. The hollow fibers have a hydrophilic interior surface and a hydrophobic... Agent: Gambro Bct, IncIPDepartment

20080254534 - Slide composter: The invention relates to a device for the composting of biogenic materials, wherein material introduced at the top of a container as in FIG. 2b reaches a storage chamber (2) arranged below a reactor chamber (1) passing therethrough only by gravity with air introduction. Slide surfaces are provided which brake... Agent: David A. Guerra International Patent Group, LLC

20080254535 - Cell separation apparatus: A conventional method of retrieving spheroids formed needs to chemically label the spheroids and may physically damage the spheroids. An apparatus according to the present invention has a nanopillar cell culture sheet, a flow speed generating section, and a spheroid retrieval section. The present invention uses the nanopillar cell culture... Agent: Antonelli, Terry, Stout & Kraus, LLP

20080254536 - Method of elevating photosynthesis speed of plant by improving pyruvate phosphate dikinase: The present invention relates to the transformation of C4 plants. It also relates to the high-level expression of foreign genes in C4 plants. More specifically, the present invention relates to the creation of C4 plants retaining an excellent photosynthetic capacity at low temperature by achieving high-level expression of an enzyme... Agent: Birch Stewart Kolasch & Birch

20080254537 - Compositions and methods for inducing the activation of immature monocytic dendritic cells: The present invention provides methods for inducing the maturation of immature dendritic cells (DC) and for activating those cells without the use of a dendritic cell maturation agent. The activated DC can be used for inducing an antigen specific T cell response. Methods of the invention can also comprise the... Agent: Townsend And Townsend And Crew, LLP

20080254538 - Treatment of neurological deficits in the striatum or substanta nigra pars compacta: The present invention is directed to methods of treating neurological deficits resulting from injury or disease to the striatum or substanta nigra pars compacta of a human by administering BMP7 to the striatum or substanta nigra pars compacta of a human in amounts effective to induce cell populations having the... Agent: Philip S. Johnson Johnson & Johnson

20080254539 - Mutated xylanase gene with high reaction activity and site-specific mutagenesis method thereof: A mutated xylanase gene with high reaction activity includes a fifty-eighth amino acid or a thirty-eighth amino acid generated from transforming asparagine to aspartic acid so as to form the mutated xylanase gene. A site-specific mutagenesis method includes the step of: mutating the forty-first amino acid or the thirty-eighth amino... Agent: Kamrath & Associates P.A.

20080254540 - Methods of genetically encoding unnatural amino acids in eukaryotic cells using orthogonal trna/synthetase pairs: This disclosure concerns compositions and methods for genetically encoding and expressing prokaryotic tRNAs in eukaryotic cells. In some embodiments, the disclosure concerns methods and compositions for expressing unnatural amino acids in eukaryotic cells using orthogonal tRNA/synthetase pairs. In certain embodiments, the methods involve expressing prokaryotic tRNA/synthetase pairs in eukaryotic cells,... Agent: Klarquist Sparkman, LLP

20080248458 - Purification, characterization and reconstitution of a ubiquitin e3 ligase: The present invention provides a native or reconstituted complex comprising Bmi1 and/or Ring1 and/or Ring2, wherein the complex has ubiquitin E3 ligase activity. Optionally, the complex further comprises HPH2 and/or HPC3. Also disclosed are methods of producing the reconstituted complex, methods of identifying compounds that modulate the ubiquitin E3 ligase... Agent: Myers Bigel Sibley & Sajovec

20080248457 - Sensor chip and manufacturing method thereof: A sensor chip is provided including: a substrate; a cover layer; a spacer layer sandwiched between the substrate and the cover layer; a hollow reaction section provided between the substrate and the cover layer; and a detection section provided in the hollow reaction section, wherein the substrate and the cover... Agent: Mcdermott Will & Emery LLP

20080248460 - Composition and method for modulating an inflammatory response: The invention relates to compositions and methods comprising lymphotoxin-beta receptor (LTβR) modulators, which activate or inhibit LTβR signaling. LTβR modulators are useful for treating lymphocyte mediated immunological diseases and cancer, and more particularly, for regulating mitochondrial-mediated apoptosis. This invention relates to soluble forms of the LTβR complex proteins that act... Agent: Ivor R. Elrifi, Esq. Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20080248459 - Multiplex detection of agricultural pathogens: Described are kits and methods useful for detection of seven agricultural pathogens (BPSV; BHV; BVD; FMDV; BTV; SVD; and VESV) in a sample. Genomic sequence information from 7 agricultural pathogens was analyzed to identify signature sequences, e.g., polynucleotide sequences useful for confirming the presence or absence of a pathogen in... Agent: Llnl/fenwick John H. Lee, Assistant Laboratory Counsel

20080248461 - Pna probes, kits, and methods for detecting genotypes of human papillomavirus: Disclosed are PNA probes capable of genotype specifically binding with Human Paillomavirus (HPV) DNA, kits for detecting HPV genotypes comprising the probes, and methods for detecting HPV genotypes by using the kits, which enables the accurate detection of all 24 genotypes of HPV found in cervix, diagnosis of combined infection... Agent: The Webb Law Firm, P.C.

20080248474 - Amplification methods: Methods are provided for amplification and monitoring of oligonucleotide amplification in which a primer has an overlap with one or more bases of a detection probe.... Agent: Townsend And Townsend And Crew, LLP

20080248482 - Biomarkers for toxic algae: The present invention is directed toward biomarkers that identify characteristics of algae. The invention is further directed toward biomarkers that serve to identify algae species and strains of algae species as well as detect the presence of algal toxins. Additional embodiments feature methods utilizing algal biomarkers and polypeptides that can... Agent: Knobbe Martens Olson & Bear LLP

20080248462 - Diagnostics and therapeutics for diseases associated with arginyl aminopeptidase (aminopeptidase b)-like 1 (rnpepl1): The invention provides a human RNPEPL1 which is associated with the cardiovascular diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases, urological diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular... Agent: Banner & Witcoff, Ltd.

20080248476 - Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods... Agent: Celera, An Applera Business Unit

20080248470 - Genetic screening for predicting antidepressant drug response based on the monoamine transporter gene polymorphism combination: The present invention discloses is a method of selecting a drug based on personal genetic information when prescribing an antidepressant for a depressed patient. According to the invention, either a noradrenaline reuptake inhibitor (NRI) antidepressant or a selective serotonin reuptake inhibitor (SSRI) antidepressant can be selected based on the combination... Agent: Mckee, Voorhees & Sease, P.L.C

20080248472 - Method and kit for determination of thymidine kinase activity and use thereof: A method and assay kit for determination of thymidine kinase (TK) activity in a biological sample, such as blood, serum, plasma, Cerebral Spinal Fluid (CSF), pleural fluid, ascites, tissues, cells and extracts thereof, is described. The method comprises contacting, in a buffer, a Basic Reaction Mixture comprising: solid surface-attached primer... Agent: Bacon & Thomas, PLLC

20080248473 - Method and kit for the detection of bacterial species by means of dna analysis: The present invention relates to the detection and identification of different bacterial species, all of which cause zoonosis, based on DNA analysis. More specifically, the invention provides the primers, probes, genes and genic regions required to apply a method for the simultaneous detection of bacteria and bacterial groups belonging to... Agent: Darby & Darby P.C.

20080248468 - Method for improved selection of rnai transfectants: The present invention is directed to a method for inactivation of expression of a gene in a eucaryotic cell comprising (i) transfection of a eucaryotic cell with DNA comprising an expression cassette for expression of a cell surface protein and an expression cassette for expression of a RNAi compound, said... Agent: Hoffmann-la Roche Inc. Patent Law Department

20080248484 - Method for the early detection of pancreatic cancer and other gastrointestinal disease conditions: The present invention uses peripheral blood monocyte-lymphocyte for the early diagnosis of pancreatic cancer, as well as other conditions of the pancreas and other organs. The peripheral blood lymphocytes recognize the new neoplasm in the pancreas, as well as disease processes in other organ systems. The evaluation of this specific... Agent: Thorpe North & Western, LLP.

20080248466 - Method of detecting mutations in the gene encoding cytochrome p450-2c19: The present invention describes a method for the simultaneous identification of two or more mutations located in the gene encoding Cytochrome P450-2C19. Multiplex detection is accomplished using multiplexed tagged allele specific primer extension (ASPE) and hybridization of such extended primers to a probe, preferably an addressable anti-tagged support.... Agent: Goodwin Procter LLP Patent Administrator

20080248464 - Method of dna shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process: Disclosed is a process of performing “sexual” PCR which includes generating random polynucleotides by interrupting or blocking a synthesis or amplification process to show or halt synthesis or amplification of at least one polynucleotide, optionally amplifying the polynucleotides, and reannealing the polynucleotides to produce random mutant polynucleotides. Also provided are... Agent: Verenium Corporation Intellectual Property Department

20080248475 - Methods and compositions for modulating gluconeogenesis using pgc-1: The invention provides novel methods and compositions for modulating gluconeogenesis through modulation of PGC-1 activity or expression. Also provided are methods for identifying compounds that modulate gluconeogenesis through modulation of PGC-1 activity or expression, as well as methods for identifying compounds that modulate the interaction of PGC-1 with PGC-1 target... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20080248471 - Methods for disease detection: The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.... Agent: Goodwin Procter LLP Patent Administrator

20080248469 - Methods for identifying nucleotides of interest in target polynucleotides: In some embodiments, the present teachings provide a method of identifying a nucleotide of interest in a target polynucleotide. In some embodiments, the method can comprise forming an amplification strand, wherein the amplification strand comprises a hairpinning end region; hybridizing the hairpinning end region of the amplification strand with a... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080248479 - Methods for isolating and characterizing endogenous mrna-protein (mrnp) complexes: Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex and include cell cultures, cell extracts, and whole tissue, including tumor... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080248481 - Methods of evaluating cells and cell cultures: Methods of evaluating the composition of a cell culture (e.g., to distinguish chondrocytes from fibroblasts) and methods for evaluating the phenotype of an individual cell (e.g., as a chondrocyte) are disclosed. The methods may be used, for example, for assessing chondrocyte cultures used for treatment of cartilage defects. In some... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080248483 - Methods of identifying therapeutic compounds in a genetically defined setting: The invention provides a method of identifying therapeutic compounds in a genetically defined setting. The method consists of contacting a cell indicative of a pathological condition from a diseased individual and a cell from a genetically related normal individual with a plurality of candidate therapeutic compounds under suitable assay conditions,... Agent: Mcdermott, Will & Emery

20080248478 - Molecular histological analysis of multicellular samples: The present invention provides modified digital images of a multicellular sample using molecular profiles of cells from said multicellular sample for a molecular histological analysis.... Agent: Roche Diagnostics Operations Inc.

20080248477 - Novel italy, lor-2, strife, trash, bdsf, lrsg, and stmst protein and nucleic acid molecules and uses therefor: Novel ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST proteins, the invention further provides isolated ITALY, LOR-2, STRIFE, TRASH, BDSF, LRSG, and STMST fusion proteins, antigenic peptides and anti-ITALY,... Agent: Millennium Pharmaceuticals, Inc.

20080248480 - Novel nucleotide mixture for improved nucleic acid amplification performance: The present invention relates to modification of amplification buffer used in amplification reactions. The modifications result in a significant improvement in results of amplification. In particular, the present invention provides methods and buffers for performing an amplification reaction utilizing a buffer comprising nucleotide triphosphates comprising treating the buffer to substitute... Agent: Elizabeth S. Worley, Esq. Biomerieux, Inc.

20080248465 - Polymorphisms in the fcgr2b promoter and uses thereof: The invention relates to the FCGR2B gene and its promoter. In particular, the invention relates to FCGR2B promoters with specific nucleotides at polymorphic sites. Characterization of the nucleotides at polymorphic sites is useful for characterizing the gene and the protein and is useful for determining predisposition or susceptibility to certain... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20080248463 - Split enzyme linked immunosorbent and nucleic acid assays: A method for detecting the presence of an analyte in a solution. The analyte includes at least two mutually exclusive recognition sites that are capable of binding to corresponding recognition molecules. Biosensors are provided that include the recognition molecules, which are attached to the inactive portions of a split enzyme.... Agent: Venable LLP

20080248467 - System for pulling out regulatory elements using yeast: Disclosed are methods for identifying molecular interactions between DNA sequences and proteins in vivo. The methods of the invention employ known or suspected DNA-binding proteins and genomic DNA in a plasmid library. Interacting molecules direct the expression of a reporter gene, the expression of which is then assayed. Also disclosed... Agent: Adams And Reese LLP

20080248491 - Biomarker fragments for the detection of human bnp: The present invention relates among other things to a composition comprising at least two (2) human BNP fragments, wherein each of the human BNP fragments of the composition are cross-linked to at least one of the other human BNP fragments of the composition.... Agent: Paul D. Yasger Abbott Laboratories

20080248489 - Methods and compositions for directed microwave chemistry: The present invention concerns a novel means by which specific chosen reactions can be accelerated through the use of a new type of artificial enzyme. The invention allows specific reactions to occur at an accelerated rate, even in the presence of other non-chosen molecules, which may be very similar in... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20080248487 - Modulation of protein functionalities: New methods for the rational identification of molecules capable of interacting with specific naturally occurring proteins are provided, in order to yield new pharmacologically important compounds and treatment modalities. Broadly, the method comprises the steps of identifying a switch control ligand forming a part of a particular protein of interest,... Agent: Hovey Williams LLP

20080248488 - Platelet-derived microparticles as a novel diagnosis maker for a cardiovascular disease: The present invention relates to a diagnosis maker for a cardiovascular disease comprising platelet-derived microparticles. The present invention also relates to a method for diagnosing a cardiovascular disease in a subject with symptoms of cardiovascular disease or suspected of having cardiovascular disease, wherein said method comprises: (a) obtaining a sample... Agent: Birch Stewart Kolasch & Birch

20080248485 - Radiolabeled 3-[3- (benzoyl-amido) benzyloxy] aspartic acid derivative and method of producing the same: wherein X represents a substituent containing a radioactive atom(s) which is selected from a straight or branched lower aliphatic alkyl group, a hydroxyl group, a straight or branched lower aliphatic alkoxy group, an amino group, a straight or branched lower aliphatic acylamido group, a halogen atom and a straight or... Agent: Drinker Biddle & Reath (dc)

20080248490 - Reagents for the detection of protein phosphorylation in leukemia signaling pathways: The invention discloses nearly 288 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose.... Agent: Simona Levi-minzi, Ph.d. General Counsel

20080248486 - Type pept1 protein assay: The present invention relates to a type PepT1 protein assay and in particular a process for identifying a substrate and/or a modulator of the PepT1 protein.... Agent: D. Peter Hochberg Co. L.p.a.

20080248492 - Membrane based assays: Membrane-based assays using surface detector array devices suitable for use with a biosensor are disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by... Agent: Perkins Coie LLP

20080248495 - Guinea pig proteinase-activated receptor 4 and its activating peptide: This invention relates to nucleic acid encoding guinea pig PAR 4 and to the protein encoded thereby. The guinea pig DNA and protein are useful for the development of models of human platelet aggregation. The invention further relates to an animal model to assess the role of PAR antagonists in... Agent: Philip S. Johnson Johnson & Johnson

20080248496 - Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver, and uses thereof: Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-gel electrophoresis or by specific binding partners, such as antibodies.... Agent: Foley And Lardner LLP Suite 500

20080248497 - Detection of anaplasma platys: The invention provides compositions and methods for the detection of Anaplasma platys polynucleotides and polypeptides.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080248498 - Methods and compositions to diagnose trichomonas infection: The present invention provides methods and compositions for diagnosing Trichomonas infection by detecting an antibody that specifically binds a Trichomonas α-actinin protein in a sample from a subject.... Agent: Myers Bigel Sibley & Sajovec

20080248500 - Apolipoprotein a-ii isoform as a biomarker for prostate cancer: The present invention provides a protein-based biomarker, ApoA-II isoform, that is useful in determining prostate cancer status in a patient. In particular, the biomarker of this invention is useful to classify a biological sample as prostate cancer or non-prostate cancer. The ability of ApoA-II to detect disease in patients with... Agent: Wilmerhale/dc

20080248499 - Methods and apparatus for the isolation and enrichment of circulating tumor cells: Embodiments in accordance with the present invention relate to methods and apparatuses for concentrating and isolating Circulating Tumor Cells (CTCs) from body fluids. One embodiment of the present invention includes a micro-fabricated or nano-fabricated device having channels configured for separating and excluding. Embodiments in accordance with the present invention utilize... Agent: Townsend And Townsend And Crew, LLP

20080248501 - Methods of diagnosing ovarian cancer and kits therefor: A method for the diagnosis of ovarian cancer comprising providing a biological sample from a subject (subject sample), and detecting the expression level of each of the markers FGF-2, CA 125 and IL-18 in the subject sample A kit comprising means for detection of an expression level of each of... Agent: Goudreau Gage Dubuc

20080248502 - Methods for detecting th1 cells: The inventors discovered that the adhesion molecule CAR, known to be localized in intracellular adhesion sites, functioned as an adhesion molecule for activated lymphocytes. Further, the inventors identified CARL, a novel CAR ligand expressed in lymphocytes, and clarified that the ligand was expressed selectively in Th1 cells. In addition, they... Agent: Townsend And Townsend And Crew, LLP

20080248503 - Methods of screening compounds to predict toxicity and residual proliferative and differentiation capacity of the lympho-hematopoietic system: The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that provide a method of screening compounds for cytotoxicity or other effects on target cell populations of the lymphohematopoietic system, including specific lineages. The methods measure the luminescent... Agent: Rosenbaum & Associates, P.C.

20080248504 - Agglutination assay: The invention relates to agglutination assays and related kits, reagents and devices. In particular methods of assaying small analytes having few epitopes are disclosed, by means of using hub moieties to which multiple analytes may be bound by a first epitope, together with a further moiety capable of binding a... Agent: Speckman Law Group PLLC

20080248505 - Detection of lipid oxidising abzymes in samples: This invention relates to the finding that lipid oxidising abzymes damage Chlamydia antigens in a sample and the extent of damage provides a measure of the level or activity of the abzymes in the sample. Lipid oxidising abzymes may be measured or detected, for example, by abrogating or abolishing abzyme... Agent: Nixon & Vanderhye, PC

20080248493 - Acridinium phenyl esters useful in the analysis of biological samples: The present invention relates to methods and kits for detecting an analyte in a test sample using acridinium-9-carboxylate aryl esters.... Agent: Paul D. Yasger Abbott Laboratories

20080248494 - Test methods and devices: A method and test device for differentiating between states of an analyte that can exist in different forms, such as follicle stimulating hormone (FSH). The method or test device uses two contemporaneous assays, the first of which does not differentiate between the two analyte states and the second of which... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080248507 - C-erbb-2 external domain: gp75: m

20080248506 - Method of monitoring anti-tumor activity of an hdac inhibitor: The present invention relates to the method of determining the anti-tumor activity of a histone deacetylase inhibitor by measuring the phosphorylation of the histone variant H2AX or the level of cytokeratin-18 fragment aa 387-397.... Agent: Wilson Sonsini Goodrich & Rosati

20080248508 - Methods of making a chitosan product having an ultra-low endotoxin concentration and the ultra-low endotoxin chitosan product derived therefrom and method of accurately determining inflammatory and anti-inflammatory cellular response to such materials: Chitosan is a natural product having wide range of applications in the food and cosmetic industries. Food and commodity grade chitosan are laden with pyrogens, such as endotoxins and proteins which limit its applicability in the biological and medical arenas, as minute amounts of endotoxins may induce adaptive and innate... Agent: Bartunek & Bhattacharyya, Ltd.

20080248510 - Human fc gamma receptor iii: The present invention relates to the field of human immunoglobulin receptors, specifically the glycostructure of a human Fc gamma receptor IIIa recombinantly expressed in human embryonic kidney cells and Chinese hamster ovary cells.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20080248509 - Method for diagnosis of alzheimer's disease with determination of lasp-1 immunoreactivity: Method for early diagnosis and diagnosis, for prognosis and assessment of the severity and for therapy-accompanying monitoring of inflammatory diseases and infections, in particular sepsis-like systemic infections and Alzheimer's disease, in which the presence and/or amount of the protein LASP-1 (SEQ ID NO:1) or of the protein LAP-1 (SEQ ID... Agent: Kathy Smith Dias, Esq. Heslin Rothenberg Farley & Mesiti P.C.

20080248511 - Methods to quench light from optical reactions: The present invention relates to single and dual reporter luminescence assays utilizing reagents to quench an optical, e.g., an enzyme-mediated luminescence, reaction. In one embodiment of the invention, a reagent is added to an assay which selectively quenches a first enzyme-mediated luminescence reaction without affecting a subsequent distinct enzyme-mediated luminescent... Agent: Schwegman, Lundberg & Woessner, P.A.

20080248512 - Methods for detection of lysosomal storage disease: The present invention provides compositions for performing assays of enzyme activity associated with lysosomal storage diseases. The invention further provides methods for determining enzyme activity, and methods for the screening for lysosomal storage disease in an individual.... Agent: Edwards Angell Palmer & Dodge LLP

20080248513 - Methods for detection of lysosomal storage disease: The present invention provides compositions for performing assays of enzyme activity associated with lysosomal storage diseases. The invention further provides methods for determining enzyme activity, and methods for the screening for lysosomal storage disease in an individual.... Agent: Edwards Angell Palmer & Dodge LLP

20080248514 - Electrochemical method for glucose quantification, glucose dehydrogenase composition, and electrochemical sensor for glucose measurement: A method of quantifying glucose in a solution characterized in that electric potential measurement is conducted by potentiometry using a glucose dehydrogenase that requires a flavin compound as a coenzyme. It is preferable to carry out the quantification using a glucose dehydrogenase derived from a filamentous fungus, in particular derived... Agent: Leydig Voit & Mayer, Ltd

20080248516 - Method for using division arrested cells in screening assays: Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays.... Agent: Invitrogen Corporation C/o Intellevate

20080248515 - Optimizing culture medium for cd34<+> hematopoietic cell expansion: The present invention provides a method of determining the optimal composition of a serum-free, eukaryotic cell culture medium supplement, using 2-level factorial design and the deepest ascent method. The invention further provides a method of making a serum-free eukaryotic cell culture medium supplement and the generated thereof. The invention further... Agent: Wpat, PC Intellectual Property Attorneys

20080248517 - Diagnostic device: Diagnostic devices for detecting the presence of an analyte in a sample are provided. Devices of the present invention comprise a means for inducing a pressure differential on a sample to direct the sample to a test surface. In one embodiment, the means for inducing a pressure differential on a... Agent: Dority & Manning, P.A.

20080248518 - E.coli and salmonella test kit: A method for testing for the presence of bacteria in the field includes using a mixer and frother or a reagent to disrupt bacteria cells. A sample is collected from a source suspected to be contaminated by bacteria. A mixer and frother or similar mixer is used to mix the... Agent: Averill & Varn

20080248519 - Agitator for a fermenter, fermenter and method for operating a fermenter: m

20080248520 - Process for production of 5-ene-3-one or 3,6-dione derivatives of sterols, processes for production of lipid metabolism improvers, foods, drinks, and animal feeds, and analytical method: The process for production of 5-ene-3-one or 3,6-dione derivatives of sterols of the present invention involves preparing a culturing solution containing an Arthrobacter bacterium, which is a microorganism exhibiting a cholesterol oxidase activity, and then, adding to the culturing solution an equivalent amount of hexane so as to prepare a... Agent: Morgan Lewis & Bockius LLP

20080248521 - Enhanced cell-free synthesis of active proteins containing disulfide bonds: Compositions and methods are provided for the enhanced in vitro synthesis of active polypeptides containing disulfide bonds. In certain embodiments of the invention, the reaction mix includes a biological extract derived from a bacterial cell in which the glutathione reductase gene has been inactivated, which is pre-treated with a low... Agent: Bozicevic, Field & Francis LLP

20080248522 - High-pressure inclusion body solubilization and protease clipping of recombinant fusion proteins: Described herein are methods for the solubilization and proteolytic cleavage of fusion protein aggregates, including autocatalytic fusion proteins, at pressures greater than atmospheric pressure to yield soluble target polypeptides.... Agent: Morrison & Foerster LLP

20080248524 - Amp deaminase originating streptomyces and utilization thereof: It is intended to provide a thermostable AMP deaminase originating in a microorganism. Namely, an AMP deaminase having the following characteristics. (1) Catalyzing the reaction: 5′-adenylic acid+H2O→5′-inosinic acid+NH3; (2) being stable at a temperature of 65° C. or below (in an acetate buffer (pH 5.6)); (3) having a molecular weight... Agent: Edwards Angell Palmer & Dodge LLP

20080248527 - Binding phenol oxidizing enzyme-peptide complexes: The present application relates to peptides which bind to a target stain, phenol oxidizing enzyme-binding peptide complexes wherein the binding peptide is attached to the C-terminus of the phenol oxidizing enzyme or is inserted or substituted into the phenol oxidizing enzyme. In a preferred embodiment the phenol oxidizing enzyme is... Agent: Genencor International, Inc. Attention: Legal Department

20080248526 - Recombinant cell lines for the stable and high-level production of biologically active dkk1 protein: This invention relates to the use of specific recombinant cell lines in order to produce biologically active DKK1 protein in a stable and high-level manner. The invention also relates to these recombinant cell lines, as well as a method for stable and high-level production of biologically active DKK1 protein, implementing... Agent: Crowell & Moring LLP Intellectual Property Group

20080248525 - Twin-arginine translocation in bacillus: Described herein are methods to enhance protein secretion in a host cell. In preferred embodiment, the host cell is a gram-positive microorganism such as a Bacillus. In another preferred embodiment, the host cell is a gram-negative microorganism. Preferably the gram-negative microorganism is an Escherichia coil or a member of the... Agent: Genencor International, Inc. Attention: Legal Department

20080248523 - Utilisation of constructs comprising recombination sequence motifs for enhancing gene expression in moss: A method of amplifying gene expression in a moss plant cell or moss tissue, DNA constructs therefor, moss plant cells and uses thereof for the production of protein.... Agent: Griffin & Szipl, PC

20080248528 - Erythrovirus and its applications: The invention relates to nucleic sequences derived from a human erythrovirus type V9, fragments of the sequences and their methods of use including applications as a diagnostic reagent and as immunogenic agent.... Agent: Foley & Lardner LLP

20080248529 - Modified anti-cd52 antibody: The present invention provides for modified forms of anti-CD52 antibodies with reduced numbers of potential T-cell epitopes that are expected to display decreased immunogenicity.... Agent: Fulbright & Jaworski L.L.P.

20080248530 - Use of fungal mutants for expression of antibodies: The present invention relates to a filamentous fungal cell in which an endogenous alkaline protease activity, an endogenous neutral metalloprotease activity and an endogenous serine protease activity of the subtilisin type have been completely or partially inactivated. Particularly the endogenous alkaline protease activity, the endogenous neutral metalloprotease activity and the... Agent: Novozymes North America, Inc.

20080248531 - Preparation of fully human antibodies: The present invention provides a method of preparing fully human antibodies that recognize a pre-determined antigen without relying on human donors that have already been exposed to the antigen. To this end, lymphocytes from naive human donors are immunized in vitro with the antigen of interest, and cells that produce... Agent: Li-te Chin

20080248532 - Enzymatic method for producing dihydroxyacetone phosphate: e

20080248533 - method for in vitro molecular evolution of protein function:

20080248534 - Adaptive thermal block temperature control method and system: Aspects of the present teachings describe a method and apparatus for automatically controlling a block temperature to reduce undershooting and overshooting of the temperatures of a sample contained in the block and participating in a polymerase chain reaction (PCR). The adaptive thermal block temperature control begins when a sample temperature... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080248535 - Rapid one-step reverse transcriptase pcr: The present invention is directed to a method for performing a one-step RT-PCR for amplifying a target RNA comprising the steps (i) providing a sample which is supposed to contain said target RNA (ii) adding a reaction mixture comprising all reagents necessary to reverse transcribe said target RNA into cDNA... Agent: Roche Diagnostics Operations Inc.

20080248536 - Polynucleotide ligation reactions: The method of the invention improves the specificity of a ligation reaction carried out between a first double-stranded polynucleotide having a single-stranded portion and a second polynucleotide having a complementary single-stranded portion, the second polynucleotide being present in a sample comprising a mixture of different polynucleotides. The method comprises contacting... Agent: Marshall, Gerstein & Borun LLP

20080248537 - Biocatalytic asymmetric reduction in preparation of (s)-n-[5-(1,2-dihydroxy-ethyl)-pyrazinyl]-2,2-dimethyl-propionamide: e

20080248538 - Cyanide-tolerant nitrile hydratases: Disclosed herein are cyanide-tolerant nitrile hydratases especially from Pseudomonas putida or Pseudomonas marginalis strains which exhibit increased cyanide tolerance. Also disclosed are methods of preparing amides from nitriles in the presence of cyanides and polynucleotide sequences coding for cyanide-tolerant nitrile hydratases.... Agent: Smith, Gambrell & Russell

20080248539 - Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor: The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure... Agent: Dechert LLP

20080248540 - Methods of producing butanol: A method of producing butanol from carbohydrates is provided. A feedstock comprising a carbohydrate source is fermented in the presence of bacteria to produce butyric acid and hydrogen. The butyric acid is then hydrogenated in the presence of a catalyst to produce butanol.... Agent: Dinsmore & Shohl LLP

20080248542 - Clostridium difficile culture and toxin production methods: The invention provides methods and compositions for use in culturing Clostridium difficile and producing Clostridium difficile toxins.... Agent: Pearl Cohen Zedek Latzer, LLP

20080248541 - Equipment and method for dry ferment: The present invention relates to a method for dry fermentation and equipment for carrying out the same. The invention equipment comprises a fermentation tank for dry fermentation which includes a tank body 5 for accommodating materials, a flexible sealing membrane 7 for covering said tank body 5, and a tight... Agent: Gottlieb Rackman & Reisman PC

20080248543 - Method for removing enzyme and method of base exchange or hydrolysis of phospholipid using the same: A method of removing an enzyme from a liquid enzyme reaction mixture used in a hydrolysis reaction or a base exchange reaction of a phospholipid is provided. The method includes the step of treating the liquid enzyme reaction mixture with a solvent mixture of water and an organic solvent, wherein... Agent: The Webb Law Firm, P.C.

20080248544 - Methods and compositions for grafting functional loops into a protein: The present invention provides targeted enzymes that bind to targets better than the corresponding pre-targeted enzymes bind the target under like conditions, methods of making targeted enzymes, methods of using targeted enzymes to treat diseases, and pharmaceutical compositions comprising targeted enzymes.... Agent: H. Thomas Anderton, Jr. Genencor International, Inc.

20080248545 - Methods for generating novel stabilized proteins: The disclosure provides methods for identifying and producing stabilized chimeric proteins.... Agent: Gavrilovich Dodd & Lindsey LLP Joseph R. Baker, Apc

20080248546 - Mutant 2,5-diketo-l-gluconic acid reductases: Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated from the environment using PCR methods are described.... Agent: Richard T. Ito Genencor International, Inc.

20080248549 - Glutathione s-transferase sequence variants: Isolated GSTO2 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as GSTO2 allozymes. Methods for determining if a subject contains a GSTO2 sequence variant also are described.... Agent: Fish & Richardson P.C.

20080248548 - Modulation of protein functionalities: New methods for the rational identification of molecules capable of interacting with specific naturally occurring proteins are provided, in order to yield new pharmacologically important compounds and treatment modalities. Broadly, the method comprises the steps of identifying a switch control ligand forming a part of a particular protein of interest,... Agent: Hovey Williams LLP

20080248547 - Novel glyphosate-n-acetyltransferase (gat) genes: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds,... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20080248550 - Enhancement of vanadium-containing phosphatase inhibitors: The present invention is directed to a composition comprising a vanadium-containing phosphatase inhibitor and a polyol. In the presence of the polyol the effect of the inhibitor is enhanced, even in the presence of chelating agents or reducing agents. The invention also concerns the use of the inventive composition for... Agent: Roche Diagnostics Operations Inc.

20080248551 - Methods and compositions for live attenuated viruses: Embodiments herein relate to compositions of and methods for live viruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated viruses and compositions to reduce inactivation and/or degradation of the live, attenuated virus. In other embodiments, the live, attenuated virus... Agent: Faegre & Benson LLP Patent Docketing

20080248552 - Method of cell cultures and device for implementing it: The invention generally provides a cell culture vessel having at least one first zone and at least one second zone, wherein the first zone is a transfer zone for a culture medium which essentially contains no cells and the second zone is a cell culture zone. The invention further includes... Agent: Clark & Elbing LLP

20080248553 - Production of bioavailable folic acid: The invention provides a process of producing bio-available folate, i.e., folic acid having an increased proportion of monoglutamyl folate and a decreased proportion of polyglutamyl folate, by culturing food-grade microorganisms containing an active heterologous or homologous polyglutamyl hydrolase activity or containing increased activities of folate biosynthesis enzymes. The genes encoding... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080248554 - Devices and methods for selectively lysing cells: A device for generating microbubbles in a gas and liquid mixture and injection device, the device comprising: a housing defining a mixing chamber; means for mixing solution contained in the mixing chamber to generate microbubbles in the solution; a needle array removably attached to the housing and in fluid connection... Agent: Fulwider Patton - Cabochon Aesthetics

20080248555 - Bacterial consortium nbc2000 and method for biologically treating endocrine disrupters using the nbc2000: Disclosed is a novel bacterial consortium comprise bacterial strains useful for effectively treating endocrine disrupters and a method for treating endocrine disrupters using the same. The invention provides a method for biologically restoring soils, wastes and water, etc. which are polluted with chlorinated compounds such as polychlorinated biphenyl (PCBs), dioxin,... Agent: Casella & Hespos

20080248557 - Method of detoxication of yperite by using haloalkane dehalogenases: The method of detoxification of yperite—bis(2-chloroethyl)sulfide—by the use of a haloalkane dehalogenases or their compositions, the method of preparation of dehalogenationating enzymes and of decontamination compositions which contains at least one wild type and/or modified haloalkane dehalogenase (EC 3.8.1.5) as an chemically active component. The preferred dehalogenases are LinB from... Agent: Notaro And Michalos

20080248556 - Use of sonication to eliminate prions: The present disclosure generally relates to methods for disinfecting surfaces. More particularly, the present disclosure relates to methods for destroying prion molecules using a combination of ultrasonic energy and enzyme treatment that is effective to denature and degrade prion proteins.... Agent: Christopher M. Goff (27839) Armstrong Teasdale LLP

20080248558 - Methods for preventing, removing, reducing, or disrupting biofilm: The present invention relates to methods for preventing, removing, reducing, or disrupting biofilm present on a surface, comprising contacting the surface with an alpha-amylase derived from a bacterium.... Agent: Novozymes North America, Inc.

20080248559 - Method for selectively separating and purifying rna and method for separating and purifying nucleic acid: A method for selectively separating and purifying RNA from a mixture solution of nucleic acid containing DNA and RNA, wherein the method comprising the steps of: (1-a) adsorbing nucleic acid; (1-b) washing; (1-c) subjecting to a DNase treatment; (1-d) washing; and (1-e) desorbing the RNA from a nucleic acid-adsorbing porous... Agent: Birch Stewart Kolasch & Birch

20080248560 - Method of treatment of tissue processing fluid and apparatus therefor: The present invention relates to the field of tissue processing, particularly, to the treatment of fluids used in tissue processing. In one embodiment the present invention provides for treating a tissue processing fluid comprising first processing fluid comprising a first processing fluid and a second contaminating fluid, by: gradually varying... Agent: Sughrue Mion, PLLC

20080248561 - Molecular characterization with carbon nanotube control: There is provided a first reservoir containing a liquid solution including a molecule to be characterized and a second reservoir for containing a liquid solution including a molecule that has been characterized. A solid state support structure is provided including an aperture having a molecular entrance providing a fluidic connection... Agent: Theresa A Lober T.a. Lober Patent Services

20080248562 - Microorganism separation device: A microorganism separation device includes: sample solution supply means (30) for supplying a sample solution (40) stored within a sample solution reservoir (32) to a first flow path (12); a microorganism sensor (22) that is capable of detecting a monadelphous microorganism in the sample solution (40) that passes through the... Agent: Mattingly, Stanger, Malur & Brundidge, P.C.

20080248563 - Specimen container for the micro manipulation and biopsy in in-vitro fertilization: A container or dish is useful for the micro manipulation, micro injection, biopsy and fertilization in oocyte and embryo manipulation and culturing. The dish allows the user to more readily perform procedures used to fertilize oocytes by Intracytoplasmic sperm injection (ICSI) or other procedures, biopsy embryos and perform additional procedures... Agent: William W. Jones

20080248564 - Novel property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses: The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics... Agent: Cheryl H Agris Phd

20080248565 - Isolated phospholipid-protein particles: Systems and methods are provided for producing a protein of interest that is typically not amenable to expression in soluble form in in vitro expression systems. In some aspects, the invention provides methods of synthesizing proteins using in vitro protein synthesis systems that include a scaffold protein such as apolipoprotein... Agent: Invitrogen Corporation C/o Intellevate

20080248566 - Matriptase, a serine protease and its applications: The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or two-chain forms of matriptase in the tissue. The invention is further directed to a method of treating malignancies, which... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20080248567 - Methods and products for embryonic stem cell culture: The invention relates to methods and media for preparing and maintaining self-renewing pluripotent embryonic stem cells. The methods include, in some embodiments, culturing embryonic stem cells in culture medium that includes culture medium conditioned by cells that express wnt3a.... Agent: Wolf Greenfield & Sacks, P.C.

20080248568 - Directed neural differentiation: Differentiation towards a neural fate, and away from a non-neural fate, is promoted by activation of Notch signalling in ES cells and then transferring the cells into neural differentiation protocols. Media for neural differentiation comprises a Notch activator, e.g. a notch ligand that can be clustered. Genetic manipulation is used... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080248569 - Self-assembling peptide amphiphiles for tissue engineering: The present invention provides for compositions and methods for creating self-assembled peptide amphiphile (PA) structures. In particular, the present invention provides for two and three-dimensional structures of crosslinked PA microtexture structures useful for tissue engineering and drug discovery.... Agent: Casimir Jones, S.c.

20080248570 - Complexes of hyaluronans, other matrix components, hormones and growth factors for maintenance, expansion and/or differentiation of cells: A method is provided of propagating hepatic cells including hepatic progenitors ex vivo on or in hyaluronans with or without other extracellular matrix components (such as collagens, basal adhesion molecules, proteoglycans or their glycosaminoglycans) and with or without hormones and/or growth factors. Compositions comprising the matrix are also disclosed. Also,... Agent: Foley And Lardner LLP Suite 500

20080248571 - Method of production of artificial skin: A method for production of artificial skin by administering matrix metalloproteinase inhibitor or matrix metalloproteinase inhibitor and matrix protein production promoting agent. The matrix metalloproteinase inhibitor is N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](3-picolyl)amino]-3-methylbutanamide hydrochloride.... Agent: Fish & Richardson PC

20080248572 - Bioreactor surfaces: The present invention relates to treatment of polymeric bioreactor surfaces, to promote the proliferation of adherent cells.... Agent: Gambro Bct, IncIPDepartment

20080248573 - Mixture for oocytes maturation in art laboratory: Women over 40 years and those who had ovarian problems suffer from low pregnancy rate after Assisted Reproduction Technology (ART) procedure due to immature oocytes. According to the invention a mixture is added to these oocytes. This mixture consists of two substances: Substance 1 which has the ability of stimulating... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20080248574 - Antagonists of the interaction of melanoma inhibitory activity (mia) and p66shc: The invention provides polypeptides, nucleic acids encoding the polypeptides, optionally in a vector, and their use in methods to disrupt the interaction between p66shc and Melanoma Inhibitory Activity (MIA) in a cell and to sensitize a cell to oxidative stress.... Agent: Leydig Voit & Mayer, Ltd

20080248575 - Drug and gene delivery by polymer nanonozzle and nanotip cell patch: Delivery of drugs or genes to individual cells is achieved on a nanoscale using electroporation techniques. In one method, a flow-through bioreactor having an inlet and an outlet connected by a flow chamber and a nanoporous membrane positioned in the flow chamber is used. Cells to be electroporated are flowed... Agent: Standley Law Group LLP

20080248576 - Genetic inhibition of double-stranded rna: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of... Agent: Morgan Lewis & Bockius LLP

20080241815 - Methods for inducing the differentiation of blood monocytes into functional dendritic cells: Methods are provided for inducing differentiation of blood monocytes into functional antigen presenting dendritic cells. The blood monocytes are treated by exposing the monocytes to proteins adhered to the surface of a treatment device to induce differentiation of the monocytes in to dendritic cells. The treated monocytes may be co-incubated... Agent: Mccarter & English LLP Cityplace I

20080241817 - Detection of no by using guanylyl cyclase and cgmp production as a readout system: The present invention relates to a method for determining NO enzymatically and its use for the identification of substances which can modulate a nitric oxide synthase activity.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20080241816 - Method for stabilizing oxidizable color developing reagent: A method of storing/stabilizing an oxidizable color-assuming reagent, especially a leuco dye; and a stabilized reagent obtained thereby. The method of stabilizing an oxidizable color-assuming reagent comprises storing the oxidizable color-assuming reagent in a solution having a pH of 1 to 5.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080241821 - Assay for porcine circovirus production: The present invention provides methods for the determination of the viral titer of a culture of host animal host cells infected with a circovirus. The FACS-based methods of the invention may include determining the viability of the host cells in a cell culture medium supernatant and of those cells that... Agent: Frommer Lawrence & Haug

20080241819 - Method and apparatus for enhanced bacteriophage-based diagnostic assays by selective inhibition of potential cross-reactive organisms: A sample to be tested for the presence of a target microorganism is exposed to bacteriophage and conditions are provided to inhibit phage attachment to or replication in a potentially cross-reactive, non-target microorganism. The sample is incubated and assayed to detect the presence or absence of a bacteriophage marker to... Agent: Patton Boggs LLP

20080241818 - Method and microarray for detecting herpesviruses: The present invention relates to a method and to a microarray for detecting herpesviruses. The invention provides new primers and oligonucleotides for detecting herpesviruses, in particular herpesviruses selected from the group comprising HSV-1, HSV-2, CMV, EBV, VZV, HHV-6A, HHV-6B and HHV-7. By using the method of the invention several different... Agent: Dodds & Associates

20080241820 - Multiplex cellular assays using detectable cell barcodes: We describe herein a cell-based multiplexing technique called detectable cell barcoding (DCB). In DCB, each individual sample is labeled with a different DCB signature that distinguishes each sample by one or both of detected intensity or type of detection characteristic. The samples are then combined and analyzed for a detectable... Agent: Bozicevic, Field & Francis LLP

20080241837 - Automated method for determining the presence of a target nucleic acid in a sample: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080241828 - Detection of dna methylation using raman spectroscopy: Epigenetic events such as DNA methylation play important roles in the regulation of gene expression. DNA methylation patterns have been found to differ between healthy and diseased tissue, such as healthy and cancerous tissue, thereby allowing DNA methylation to serve as a biomarker for disease states. Embodiments of the invention... Agent: Intel/bstz Blakely Sokoloff Taylor & Zafman LLP

20080241844 - Devices and methods for the performance of miniaturized in vitro assays: This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention specifically provides devices and methods for performing miniaturized in vitro assays on biological samples, such as the polymerase chain reaction and Sanger sequencing reactions. Methods specific for the apparatus of the invention for... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080241835 - Differentially expressed genes involved in angiogenesis, the polypeptides encoded thereby, and methods of using the same: The present invention is directed to nucleic acid sequences and the polypeptides encoded thereby that are differentially expressed in angiogenesis. Also provided are methods for stimulating or inhibiting angiogenesis in mammals, including humans. Pharmaceutical compositions based on polypeptides, agonists, or antagonists thereto are also provided. Additionally, the invention also provides... Agent: Merchant & Gould PC

20080241830 - Digital amplification: The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable for this purpose. Single molecules... Agent: Banner & Witcoff, Ltd.

20080241842 - Gene methylation as a biomarker in sputum: The present invention provides for a method to monitor the health of a subject. The method includes obtaining a test sample from the patient. A first probe specific for a CpG promoter region of a biomarker selected from p16, MGMT, PAX-α, PAX5-β, RASSF1A, HLHP, GATA4, GATA5, SFRP1, LAMC2, IGFBP3, H-cadherin,... Agent: Peacock Myers, P.C.

20080241846 - Genetic polymorphisms associated with coronary events and drung response, methods of detection and uses thereof: The present invention provides compositions and methods based on genetic polymorphisms that are associated with coronary heart disease (particularly myocardial infarction), aneurysm/dissection, and/or response to drug treatment, particularly statin treatment. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid... Agent: Celera, An Applera Business Unit

20080241822 - Genome-wide location and function of dna binding proteins: The present invention relates to a method of identifying a region (one or more) of a genome of a cell to which a protein of interest binds. In the methods described herein, DNA binding protein of a cell is linked (e.g., covalently crosslinked) to genomic DNA of a cell. The... Agent: Bozicevic, Field & Francis LLP (whitehead Institute Of Biomedical Research)

20080241825 - Materials and methods for treatment of cancer: Glypican 5 is shown for the first time to have a role in proliferation of cancer cells, including tumours which do not show chromosomal amplification at 13q31. The use of glypican 5 (GPC5) antagonists and binding agents for the treatment of cancer, particularly rhabdomyosarcoma and breast cancer, is disclosed.... Agent: Heller Ehrman LLP

20080241847 - Method and apparatus for in vivo surveillance of circulating biological components: The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis.... Agent: Knobbe Martens Olson & Bear LLP

20080241841 - Method and apparatus for sample preparation: A method of the present invention comprises fractionating a sample solution containing analyte DNA molecules into small droplets, wherein the number M of the droplets is greater than the total number N of the DNA molecules, subjecting an emulsion containing the droplets to, for example, PCR amplification, and detecting the... Agent: Stanley P. Fisher Reed Smith LLP

20080241839 - Method for correlating differential brain images and genotypes; genes that correlate with differential brain images: Methods of assigning quantitative phenotype measurement summary statistics to differential brain image information associated with neuropsychiatric disorders are provided. Summary statistics are correlated to genotype information to identify loci that correlate with differential brain image phenotypes. Methods of identifying modulators of genes at the loci are provided, as well as... Agent: Quine Intellectual Property Law Group, P.C.

20080241823 - Method for hla typing: A method for the identification of DNA sequence elements in complex and highly variable sequences is described. The method consists of identifying a short sequence element of several DNA bases (2-6 bases) at a given position in the genome simultaneously on all parental alleles. The method allows differentiating mini-haplotypes on... Agent: Foley And Lardner LLP Suite 500

20080241834 - Method for improving neoadjuvant chemotherapy: Disclosed is a method and composition for optimizing the efficiency of breast cancer neoadjuvant chemotherapy, depending on the particular constitutional genotype characteristics of the gene BRCA1 in each patient. Generally, the invention concerns a new method to improve neoadjuvant therapy depending on a particular constitutional genotype. Subject of invention allow... Agent: Cooper & Dunham, LLP

20080241832 - Method of detecting and quantifying hepatitis c virus: Methods, reagents, and kits for detecting hepatitis C virus (HCV) in biological samples.... Agent: Dykema Gossett PLLC

20080241845 - Method of extracting chromatin fractions from intact cells: Methods are provided for isolation of chromatin fractions of nucleoproteins containing histone H1, H2A, H2B, H3 and H4 proteins and/or histone H1, H2A, H2B, H3 and/or H4 proteins, from intact cells. The methods preserve original patterns of covalent modifications of the histone proteins.... Agent: Jesse A. Hirshman, Esq.

20080241849 - Methods and compositions for diagnosing epithelial cell cancer: Provided is a method for detecting metastases of epithelial cancers, comprising detecting in non-primary tissue overexpression of a nucleic acid of KS1/4, or detecting in non-primary tissue overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20080241829 - Methods and kits for producing labeled target nucleic acid for use in array based hybridization applications: Methods for producing labeled probe nucleic acids from genomic nucleic acid template are provided. In some embodiments of the subject methods, a plurality of sequence-specific primers are employed to enzymatically generate a set of labeled target nucleic acids corresponding to coding regions of genes from a genomic template via a... Agent: Agilent Technologies Inc.

20080241838 - Methods and systems for detecting nucleic acids: Methods and kits for detecting a target nucleic acid in a sample are described. In some embodiments, the sample to be analyzed includes a primer which hybridizes to at least a portion of the target nucleic acid, a probe having a first region which hybridizes to at least a portion... Agent: Morris Manning Martin LLP

20080241827 - Methods for detecting a mutant nucleic acid: The invention relates to methods for detection of genomic variation. The invention may be used to analyze nucleic acid sequences to detect low frequency mutations in a sample and/or screen for the presence of a disease.... Agent: Goodwin Procter LLP Patent Administrator

20080241831 - Methods for detecting small rna species: The invention provides a method of detecting small target nucleotide sequences, in particular, small RNA species that are present in a sample. The method generally comprises a poly-A polymerization step or a ligation step to add a universal sequence to the 3′-end of all RNA molecules, followed by a universal... Agent: Mcdermott, Will & Emery

20080241848 - Methods for prenatal diagnosis of aneuploidy: Methods are disclosed for the automated prenatal genetic diagnosis of aneuploidy using an automated fluorescence microscope, conducted on samples of maternal blood that have been hybridized with FISH probes.... Agent: Kelley Drye & Warren LLP

20080241840 - Methods of detection using immuno-q-amp technology: The present invention describes, in certain embodiments, a composition for detecting a tau protein comprising a modified detector molecule having two ends, a first end capable of binding the tau protein and a second end comprising a single-stranded DNA template, wherein the template is capable of being replicated by an... Agent: Kalow & Springut LLP

20080241824 - Mutation associated with lacunar strokes: The present invention relates to a method of identifying a subject predisposed to lacunar stroke. The method includes the step of identifying in the subject the presence of a thymine to cytosine mutation at position -107 in both alleles of the paraoxonase 1 locus.... Agent: Birch Stewart Kolasch & Birch

20080241826 - Probe and primer for tubercle bacillus detection, and method of detecting human tubercle bacillus therewith: An object of the present invention is to provide a novel primer and prove for detecting tubercle bacillus capable of avoiding false positive, and an easy-to-use, rapid and high-sensitivity method for detecting human tubercle bacillus (Mycobacterium tuberculosis) using the same. The present invention relates to an oligonucleotide comprising a part... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080241836 - Process for self-assembly of structures in a liquid: A process and apparatus for self-assembling a number of elements and determining their sequence is provided. In the field of DNA analysis, an iterative process is disclosed wherein an apparatus with a set of reaction chambers in which a species of recognition element nucleotides are differentially added and subjected to... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20080241843 - Single-cell analysis systems, methods of counting molecules in a single-cell, cylindrical fluorescence detection systems: Embodiments of the present disclosure provide for single-cell analysis systems, methods of detecting target components in a single cell, cylindrical fluorescence detection systems, and the like.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20080241833 - System and method for nucleic acid sequencing by polymerase synthesis: This invention relates to improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single molecule detection of fluorescent labeled PPi moieties released from NTPs as a polymerase extension product is created.... Agent: Townsend And Townsend And Crew, LLP

20080241851 - Cartilage intermediate layer protein 2 c1 and its use to differentiate osteoarthritis from rheumatoid arthritis and non-disease conditions: A method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of human cartilage intermediate layer protein 2(CILP-2) in body fluids and more specifically, measuring in the sample the concentration of the N-terminal part of CILP-2 (2C1) or fragments... Agent: Lynn E Barber

20080241852 - Compositions, kits, and methods for identification, assessment, prevention, and therapy of endometriosis: The invention relates to newly discovered marker polypeptides associated with endometriosis. Compositions, kits, and methods for detecting, characterizing, preventing, and treating endometriosis are provided.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080241856 - Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo: The disclosure provides a method of labeling of cellular glycans bearing azide groups via a fluorescent labeling technique based on Cu(I)-catalyzed [3+2]cycloaddition (click activation) of a probe comprising an alkynyl group. The method entails generating a fluorescent probe from a nonfluorescent precursor, 4-ethynyl-N-ethyl-1,8-naphthalimide, by Cu(I)-catalyzed [3+2]cycloaddition of the alkyne group... Agent: Greenberg Traurig LLP (la)

20080241854 - Kits and methods for evaluating hair: The invention relates to kits and methods for analyzing hair, particularly for determining the amount of damage to hair, including placing hair into a solution containing at least one metal ion so that an amount of the metal ion is attached to the hair, removing the hair from the solution,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080241855 - Method for simultaneously detecting an antigen of, and an antibody against, an infectious microorganism: The invention relates to a method for detecting, in vitro, an infection with a microorganism, such as the hepatitis C virus, in a biological sample, by simultaneously detecting an antigen of this microorganism and the antibodies against this same antigen, and also to the reagents and kits implementing this method.... Agent: Jacobson Holman PLLC

20080241850 - Method of protein measurement: The present invention relates to a technique of measuring a protein based on a degree of coloring in a liquid sample mixed with a protein measurement indicator. In the present invention, information reflecting creatinine concentration in the liquid sample is obtained, and then an influence quantity caused by creatinine to... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20080241853 - Microtiter spin array: An improvement in heterogeneous immunoassays in microtiter plates to significantly reduce assay time, from as much as 50% up to 90% of what used to be typical assay times. The improvement involves the rotation of the liquid in a microtiter plate and during incubation times for antigen capture and during... Agent: Mckee, Voorhees & Sease, P.L.C

20080241857 - Netrin receptors: The invention provides methods and compositions relating to vertebrate UNC-5 proteins which function as receptor proteins for netrins, a family of cell guidance proteins. The proteins may be produced recombinantly from transformed host cells from the disclosed vertebrate UNC-5 encoding nucleic acid or purified from human cells. The invention provides... Agent: Townsend And Townsend And Crew, LLP

20080241859 - Aglyco products and methods of use: Glycoconjugates, therapeutic compositions containing the glycoconjugates and therapeutic methods of using the glycoconjugates are disclosed. In particular, peptide constituents of aglyco 10B, which are immunogenic epitopes responsible for recognition of antigens by the immune system are provided. These glycoconjugates are useful in prevention of influenza virus binding to cells, treatment... Agent: Kenyon & Kenyon LLP

20080241860 - Methods and apparatus to recognize nerve injuries: Methods and apparatus are described to recognize nerve injuries, specifically brachial plexus injuries, and their severity, preferably of newborn children. To achieve an inexpensive and quick test, which can be executed without harming the patient, it is proposed to measure the motor neuron loss by measuring a biochemical marker, i.e.... Agent: Hanley, Flight & Zimmerman, LLC

20080241858 - Rapid microbial detection and antimicrobial susceptibiility testing: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.... Agent: Dorsey & Whitney, LLP Intellectual Property Department

20080241862 - Propionyl and butyryl lysine modifications in proteins: While the identification of acetylated lysine residues on proteins is well-known, the modification of lysine residues through propionylation and butyrylation is not very well understood. A method for the identification and mapping of propionylated and butyrylated lysine residues has been developed. Anti-acetyllysine antibody, normally used to affinity purify a protein... Agent: Fulbright & Jaworski L.L.P.

20080241861 - Biological materials and methods useful in the diagnosis and treatment of diseases: The present invention relates to a method of making a β-form of a prion protein which preferably has more β-sheet than α-helix structure and is soluble in the absence of a denaturant and/or is non-aggregated and exhibits partial resistance to digestion with proteinase K. The invention also relates to use... Agent: Nikolai & Mersereau, P.A.

20080241863 - Biomarkers for liver diseases and method for using the same: Biomarkers for liver diseases and method for using the same are provided. For detecting liver cirrhosis and liver cancer, the biomarkers are selected from any one of the amino acid sequences with SEQ ID NO:1 to SEQ ID NO:24 or derivatives or fragments or variants or the combination thereof or... Agent: Bacon & Thomas, PLLC

20080241864 - Eia for monitoring legionella pneumophila presence in water samples: A qualitative and quantitative EIA for detecting L. pneumophila in water samples is disclosed. Critical to the disclosed levels of sensitivity of these EIA's is the use of antigen-specific antibodies to the target L. pneumophila antigen that have been rendered antigen-specific by affinity purification on a chromatographic column, which antibodies... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080241866 - Systems and methods for enhancing fluorescent signals: Composition, systems, apparatus and methods of enhancing fluorescent signals in biochemical are described. Metal particle proximity to enzymes that produce fluorescent products provide enhanced fluorescence of the product and plasmon resonance of the metal particle. Multi-labeled nucleotides enhance signal production. Reflectance of illumination light and emitted fluorescence increase signal strength... Agent: Quine Intellectual Property Law Group, P.C.

20080241865 - Visible to near-infrared light probe comprising complex of cypridina luciferase and quantum dot: The invention relates to a bioactive substance labeled with Cypridina luciferase and a quantum dot, the bioactive substance being at least one species selected from the group consisting of antibodies, peptides, organic compounds, hormones, enzyme substrates, sugar chains and nucleic acids.... Agent: Warren M. Cheek, Jr. Wenderoth, Lind & Ponack, L.L.P.

20080241867 - Apparatuses and methods for determining protease activity: The present invention relates to compositions and an apparatuses for determining protease activity. The compositions of the invention contain a reporter protein fused to at least one protease cleavage sequence, and a linker for attaching the protease cleavage sequence to a solid support. Methods for determining protease activity and characterizing... Agent: Licata & Tyrrell P.C.

20080241868 - Method for increasing light emission from a chemiluminescent reaction: Method for increasing the emission of light from a chemiluminescent reaction including luminol, a peroxidase enzyme, an oxidant and a mediator of electrons through the use of a hypernucleophilic acylation catalyst belonging to the class of 4-aminopyridines. It is also described the use in diagnostic assays of chemiluminescent substrates containing... Agent: Nixon & Vanderhye, PC

20080241870 - Composition for creating an artificial bone marrow like environment and use thereof: The present invention is in the domain of cell biology and medicine and relates to composition and in vitro methods for creation of artificial bone-marrow like environment and uses thereof.... Agent: Merchant & Gould PC

20080241869 - Compositions and methods for ameliorating hyperlipidemia: The invention provides compositions and methods for treating hyperlipidemia by administering a Microsomal Triglyceride Transfer Protein (MTP) inhibitor in combination with a Liver Fatty Acid-Binding Protein (L-FABP) inhibitor, methods of preventing the development of hepatic steatosis, methods of identifying an agent useful for treating hyperlipidemia, and methods of screening for... Agent: Dla Piper US LLP

20080241871 - Luminescence measuring apparatus: The present invention provides a luminescence measuring method that can be accurately and quickly carried out while inhibiting a possible background associated with viable bacteria adhering to a nozzle or Adenosine Tri Phosphate remaining in the nozzle, and an apparatus for the method. The present invention uses a washing apparatus... Agent: Stanley P. Fisher Reed Smith LLP

20080241874 - Method and device for manipulating individual small objects: A method for individually moving small objects, such as cells, from one location to another as well as a device for implementing the method is disclosed. A small object such as a cell is isolated at some initial location and moved to some destination location by the movement of the... Agent: Martin D. Moynihan Prtsi, Inc.

20080241872 - Methods of modulating cold sensory perception: The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein family, CMR1, which is involved in modulation of the perception of cold sensations and pain. The invention further relates to methods... Agent: Townsend And Townsend And Crew, LLP

20080241873 - Multi-use multimodal imaging chelates: Cyclen-based chelates can be used as contrast agents for multi-modal imaging of tissue cells. The cyclen-based chelates are preferably polyazamacrocyclic molecules formed from 1,4,7,10 tetraazacyclododecane (“cyclen”) having varying chelating ions, phosphoester chains, and light harvesting moieties. By changing the chelating ion, phosphoester chain length and/or the light harvesting moiety different... Agent: Stites & Harbison PLLC

20080241875 - Apparatus and method of detecting microorganism or micro-particle in real time: An apparatus for detecting a microorganism or micro-particle in real time includes a collection module comprising a condensation element unit which condenses water particles in an atmosphere and forms a droplet to which a microorganism or micro-particle in the atmosphere adheres to, and a collection channel unit which gathers the... Agent: Cantor Colburn, LLP

20080241876 - Information notification sample processing system and methods of biological slide processing: A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080241877 - Immobilised enzymes: The present invention relates to a method for immobilizing enzymes in a solid porous support, and to enzymes immobilized in solid porous supports. Specifically, the present invention uses a fluid containing the enzyme under high pressure (such as 25 to 50 Mpa) to immobilize the enzyme (such as CALB) on... Agent: Jones Day

20080241878 - Method for enzmatic cross-linking of a protein, cross-linked protein thus obatained and use thereof: The present invention provides methods for enzymatic cross-linking of a protein comprising performing a reaction for enzymatic cross-linking of said protein in the presence of a phenolic saccharide, wherein said reaction comprises the step of forming protein-protein cross-links. The present invention further provides a cross-linked protein obtainable by a method... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20080241879 - Microorganism and protease decomposing proteins recalcitrant to proteolysis: The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and... Agent: Bacon & Thomas, PLLC

20080241880 - Methods and compositions for determination of glycated proteins: This invention relates generally to the field of glycated protein detection. In particular, the invention provides chimeric proteins, nucleic acids encoding the chimeric proteins, methods and kits for assaying for a glycated protein in a sample, using inter alia, an amadoriase.... Agent: Morrison & Foerster LLP

20080241882 - Methods and materials relating to novel stem cell growth factor-like polypeptides and polynucleotides: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human... Agent: Robins & Pasternak

20080241881 - Modified clostridial toxins with enhanced translocation capabilities and altered targeting activity for clostridial toxin target cells: The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain, a translocation facilitating domain and an altered target domain; polynucleotide molecules encoding such modified Clostridial toxins; and methods of producing such modified Clostridial toxins.... Agent: Dean G. Stathakis (t2-7h) Allegan, Inc.

20080241883 - Recombinant expression vector elements (reves) for enhancing expression of recombinant proteins in host cells: Compositions and methods comprising recombinant expression vector elements (rEVEs) to enhance the level of expression of recombinant proteins are described. Other compositions and methods for lowering, substantially suppressing, or essentially silencing expression of a recombinant protein are also described.... Agent: Yankwich & Associates, P.C. (and Abbott Bioresearch Center)

20080241884 - Fused protein composition: The present invention provides a fusion protein composition comprising a fusion protein molecule of an antibody Fc region having complex type N-glycoside-linked sugar chains in the Fc region, wherein the complex type N-glycoside-linked sugar chains have a structure in which fucose is not bound to N-acetylglucosamine in the reducing end... Agent: Sughrue-265550

20080241885 - Process for producing cellulase: Various methods for the production of cellulase are disclosed. In one embodiment the method for producing cellulase includes contacting a culture comprising a sophorolipid producer and a cellulase producer with a substrate that is consumed by the sophorolipid producer. In addition, a microorganism culture made from a sophorolipid producer and... Agent: Roetzel And Andress

20080241886 - Process for the treatment of methane emissions: The invention relates generally to a system and method for the treatment of gaseous emissions comprising methane, and in one specific embodiment, to a system and method for the treatment of emissions through the use of methanotrophic microorganisms. Certain embodiments of the invention are particularly advantageous because they reduce environmentally-destructive... Agent: Knobbe Martens Olson & Bear LLP

20080241887 - Polypeptides with starch debranching activity: Polypeptides comprising a catalytic starch debranching domain and a starch binding domain are disclosed. The polypeptides comprising the starch binding domain have an improved functionality in raw starch degradation compared with same catalytic unit in same amount but without the starch binding domain.... Agent: Novozymes North America, Inc.

20080241888 - Method for producing purine nucleosides and nucleotides by fermentation using bacterium belonging to the genus bacillus or escherichia: Methods for producing purine nucleosides, and purine nucleotides, such as inosine and 5′-inosinic acid are provided which include using a bacterium belonging to the genus Bacillus or to the genus Escherichia wherein the purine nucleoside productivity of said bacterium is enhanced by increasing an activity of the YdhL protein. Also... Agent: Cermak & Kenealy LLP Acs LLC

20080241889 - Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites: The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites and/or multiple topoisomerase recognition sites. The methods permit the simultaneous cloning of two or more different nucleic acid molecules. In some embodiments the molecules are fused together while in other embodiments the... Agent: Invitrogen Corporation C/o Intellevate

20080241891 - Method for the amplification and detection of hbv dna using a transcription based amplification: The present invention provides a method for the transcription based amplification of a target HBV nucleic acid sequence starting from HBV DNA optionally present in a sample, comprising the steps of, —incubating the sample, suspected to contain HBV, in an amplification buffer with one or more restriction enzymes capable of... Agent: Myers Bigel Sibley & Sajovec

20080241893 - Methods for amplifying trichomonas vaginalis-derived nucleic acid: Oligonucleotides useful for determining the presence of Trichomonas vaginalis in a test sample. The oligonucleotides may be incorporated into detection probes, helper probes, capture probes and amplification oligonucleotides, and used in various combinations thereof.... Agent: Gen Probe Incorporated

20080241892 - Modified surfaces for immobilization of active molecules: Modified surfaces, substrates, and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide either non-reactive surfaces or low density reactive groups, preferably on an otherwise non-reactive surface, for use in different applications including single molecule analyses.... Agent: Quine Intellectual Property Law Group, P.C.

20080241890 - Pcr process and arrangement for dna amplification using dry reagents: A PCR process for DNA amplification with thermocyclisation of the corresponding reagents is disclosed, in which total integration of all substances and process steps is achieved in a closed, single-use unit (so-called cartridge) in which the reagents are stored in a storage-stable form at room temperature. According to the process,... Agent: Harness, Dickey & Pierce, P.L.C

20080241894 - Vector constructs: Improved vector constructs useful in the expression of double-stranded RNA are provided. The constructs are particularly useful for expression of double-stranded RNA in vitro and in vivo.... Agent: Wolf Greenfield & Sacks, P.C.

20080241895 - N-acetyl-(r,s)-beta-amino acid acylase gene: The present invention provides genes that encode the N-acetyl-(R,S)-β-amino acid acylases. The N-acetyl-(R,S)-β-amino acid acylases were isolated and purified from bacterial cells and the nucleotide sequences were determined. A host, such as Escherichia coli, was used to construct a high-expression system for these genes. The N-acetyl-(R)-β-amino acid acylase produced by... Agent: Cermak & Kenealy LLP Acs LLC

20080241896 - Process for production of optically active hydroxymethyl-substituted phenylalanine: e

20080241897 - Enzymatic oil interesterification: An improved process for enzymatic interesterification of oil containing a chelating agent with a base and a lipase.... Agent: Novozymes North America, Inc.

20080241898 - Application of glucose transport mutants for production of aromatic pathway compounds: This invention describes methods for enhancing carbon flow into a pathway of a host cell to enhance the biosynthetic production of compounds therefrom, the host cells being selected based on being phenotypically Pts−/glucose+.Such host cells are capable of transporting glucose without consuming PEP, resulting in conservation of PEP which can... Agent: Genencor International, Inc.

20080241899 - Poly (3-hydroxyalkanoate) block copolymer having shape memory effect: i

20080241900 - Highly active xylose reductase from neurospora crassa: A new xylose reductase encoding gene from Neurspora crassa was heterologously expressed in E. coli as a His-tag fusion protein and subsequently purified in high yield. This xylose reductase was shown to have a high turnover rate and catalytic efficiency, high stability at room temperature, broad pH profile, and a... Agent: Barnes & Thornburg LLP

20080241901 - Hybrid enzymes: The present invention relates to a hybrid enzyme comprising at least one carbohydrate-binding module amino acid sequence and at least the catalytic module of a glucoamylase amino acid sequence. The invention also relates to the use of the hybrid enzyme in starch processing and especially ethanol production.... Agent: Novozymes North America, Inc.

20080241902 - Production of biodiesel, cellulosic sugars, and peptides from the simultaneous esterification and alcoholysis/hydrolysis of oil-containing materials with cellulosic and peptidic content: The present invention relates to a method for producing fatty acid alkyl esters as well as cellulosic simplified sugars, shortened protein polymers, amino acids, or combination thereof resulting from the simultaneous esterification and hydrolysis, alcoholysis, or both of algae and other oil containing materials containing free fatty acids (FFA), glycerides,... Agent: Darby & Darby P.C.

20080241903 - In vivo site-sepecific incorporation of n-acetyl-galactosamine amino acids in eubacteria: Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.... Agent: Quine Intellectual Property Law Group, P.C.

20080241904 - Process for producing isomaltose and uses thereof: A novel process for producing isomaltose and uses thereof and comprising the steps of contacting saccharides, which have a glucose polymerization degree of at least two and α-1,4 glucosidic linkage as a linkage at the non-reducing end, with an α-isomaltosylglucosaccharide-forming enzyme, in the presence or the absence of α-isomaltosyl-transferring enzyme... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080241905 - Transgene delivering retrovirus targeting collagen exposed at site of tissue injury: A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at... Agent: Wilson Sonsini Goodrich & Rosati

20080241906 - Scleroprotein of an adeno-associated virus with modified chromatographic properties, the production thereof and use of the same: The invention relates to a scleroprotein of an adeno-associated virus which contains at least one mutation. Said mutation causes the chromatographic properties to be modified. The invention also relates to the production of said scleroprotein and the use thereof.... Agent: Clark & Elbing LLP

20080241907 - Extracellular bioreduction: A method for processing environmental or industrial samples to remove, reclaim or otherwise reduce the level of chemical species present in the sample that act as redox active species. The redox active species is kept in a waste chamber and is separated from an aqueous bacterial culture that is held... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory

20080241908 - Petroleum based processed detergent for dry cleaning and its use: The present invention provides compositions and methods for dry cleaning garments. The present invention provides a petroleum based processed detergent for dry cleaning and methods of use. The present invention provides methods of using the petroleum based processed detergent for dry cleaning wherein use of the detergent decreases the proliferation... Agent: Baker Botts L.L.P.

20080241911 - Analyzer: A sample analyzer for analyzing a biological sample is disclosed that comprising: a measurement specimen preparation section for preparing a measurement specimen by using a reagent and the biological sample; a irradiator for irradiating the measurement specimen with a light; a first light receiving section for receiving a light from... Agent: Brinks Hofer Gilson & Lione

20080241910 - Devices for pathogen detection: The present disclosure relates to methods, systems, devices, and microfluidic chips that may be used for the detection of pathogens.... Agent: Searete LLC Suite 110

20080241909 - Microfluidic chips for pathogen detection: The present disclosure relates to methods, systems, devices, and microfluidic chips that may be used for the detection of pathogens.... Agent: Searete LLC Clarence T. Tegreene

20080241913 - Chromatographic test device and method for detecting analyte: The present invention provides a chromatographic test device, comprising a first blood cell separation member, a second blood cell separation member and a chromatographic carrier disposed in this order from the upstream side of the direction of development of a sample, wherein the first blood cell separation member is constituted... Agent: Sughrue Mion, PLLC

20080241914 - System for automatically performing separation or purification of biological materials: A system for automatically performing the operations of separating and purifying a variety of biological materials for processing nucleic acids or biological materials from biological samples using solid materials. A base plate, a carriage attachment frame assembly including a frame and a plurality of mounting units, a magnetic bar assembly... Agent: Blakely Sokoloff Taylor & Zafman LLP

20080241915 - Dna cloning vector plasmids and methods for their use: The present invention is a group of cloning vector plasmids for use in constructing DNA molecules, such as transgenes, for the purpose of gene expression or analysis of gene expression. The present invention is also a method for using the cloning vector plasmids in a variable series of cloning steps... Agent: Intrexon Corporation

20080241916 - Multiple gene expression for engineering novel pathways and hyperexpression of foreign proteins in plants: The present invention relates in part to a tobacco chloroplast transformation vector effective for stably transforming a tobacco plant to express a multi-gene operon.... Agent: Allen, Dyer, Doppelt, Milbrath & Gilchrist, P.A.

20080241917 - Vector for delivering target substance into nucleus or cell: It is intended to provide a vector for delivering a target substance into a nucleus or a cell. This object is achieved by providing a vector for delivering a target substance into a nucleus or a cell which comprises a lipid membrane structure having a lipid membrane containing an anionic... Agent: Edwards Angell Palmer & Dodge LLP

20080241918 - Hemagglutinin polypeptides, and reagents and methods relating thereto: The present invention provides a system for analyzing interactions between glycans and interaction partners that bind to them. The present invention also provides HA polypeptides that bind to umbrella-topology glycans, and reagents and methods relating thereto.... Agent: Choate, Hall & Stewart LLP

20080241919 - Defined media for pluripotent stem cell culture: Stem cells, including mammalian, and particularly primate primordial stem cells (pPSCs) such as human embryonic stem cells (hESCs), hold great promise for restoring cell, tissue, and organ function. However, cultivation of stem cells, particularly undifferentiated hESCs, in serum-free, feeder-free, and conditioned-medium-free conditions remains crucial for large-scale, uniform production of pluripotent... Agent: Biotechnology Law Group C/o Portfolioip

20080241920 - Method of promoting differentiation of one or more human stem cells into human coronary endothelial cells on a synthetic tubular structure: A method of promoting differentiation of one or more human stem cells into human coronary endothelial cells on at least one surface of a synthetic tubular structure to be used to make a human hybrid carotid graft is provided. The method includes arranging a plurality of human stem cells on... Agent: Rene A. Vazquez Williams Mullen

20080241921 - Method of promoting differentiation of one or more human stem cells into human coronary endothelial cells on a synthetic tubular structure: A method of promoting differentiation of one or more human stem cells into human coronary endothelial cells on at least one surface of a synthetic tubular structure to be used to make a human hybrid coronary graft is provided. The method includes arranging a plurality of human stem cells on... Agent: Rene A. Vazquez Williams Mullen

20080241924 - Antibody-mediated induction of tumor cell death: This invention provides methods and reagents for inducing cell death in tumor cells. The invention provides said reagents relating to inducing tumor cell death that are antibodies to a specific target, L1CAM, and methods for using said antibodies for inducing cell death. Pharmaceutical compositions of the L1CAM antibodies for use... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080241923 - Humanized anti-ccr2 antibodies and methods of use therefor: The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of... Agent: Lowrie, Lando & Anastasi, LLP

20080241922 - Use of biocistronic dna constructs for identifying compounds that inhibit ires-dependent translation: The present invention relates to use of bicistronic DNA constructs for identifying compounds that inhibits IRES-dependent translation activity of an infectious enterovirus (EV) or encephalomyocarditis virus (EMCV) without affecting CAP-dependent translation activity of a host subject. The compounds thus identified are useful in preparation of a medicament for treating EV... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20080241925 - Three-dimensional self assembly in suspension of adherent cells: Methods and vessels for three-dimensional self-assembly of cells in suspension. The methods and vessels involve pre-coating a cell culture vessel with an adhesion-inhibiting substance such as Pluronic prior to culturing a cell therein.... Agent: Howard M Cohn Patent Attorney LLC

20080241926 - Cell adhesion on surfaces of varying topographies: Micro-topography of a surface influences cell adhesion and proliferation. To improve adhesion, polyelectrolyte multilayers (PEMs) are built on patterned support layers to increase surface wettability, thereby improving attachment and spreading of the cells. Physical parameters, such as pattern size and pitch, in part, regulate cell adhesion and proliferation. Varying the... Agent: Harness, Dickey & Pierce, P.L.C

20080241927 - Novel glyphosate-n-acetyltransferase (gat) genes: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds,... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20080241928 - Methods and compositions for acid phosphatase-1 gene inhibition: The ACP1 *A allele provides a means for diagnosing susceptibility of a human subject to hyperlipidemia, especially hyperlipidemia associated with metabolic syndrome, a means for treating, or preventing the onset of, hyperlipidemia and metabolic syndrome, and a means for screening and identifying drugs suitable for use in treating or preventing... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080241929 - Method and means for producing high titer, safe, recombinant lentivirus vectors: Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector carrying the... Agent: Jones Day

20080241930 - Paramyxoviridae virus preparations: This document involves methods and materials related to obtaining Paramyxoviridae virus preparations.... Agent: Fish & Richardson P.C.

20080241931 - System for expression of genes in plants: The present invention provides trans-complementation systems for expressing gene products in plants. In general, the invention provides systems including a carrier vector and a producer vector, both based on plant viruses. The producer vector is defective for at least one function needed for successful systemic infection of a plant, e.g.,... Agent: Choate, Hall & Stewart LLP