Chemistry: molecular biology and microbiology inventions 09/08

20080233552 - Method of cross-linking amnion to be an improved biomedical material: The present invention discloses a method of cross-linking amnion to be an improved biomedical material. The present invention adopts the amnion cross-linked by EDC (N-(3-dimethylaminopropyl)-N′-ethyl-carbodiimide HCI) or NHS (N-hydroxysuccinimide), and the cross-linked amnion not only has more resistance to protease, but also binds specific extracellular matrix (ECM) such as heparin... Agent: Alan D. Kamrath Nikolai & Mersereau, P.A.

20080233554 - Composition for preserving platelets and method of using the same: The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an anticoagulant, and an oxygen carrier, for maintaining the freshness of platelets. Additionally,... Agent: Morris Manning Martin LLP

20080233553 - Method and apparatus for separating and harvesting cells from a whole blood sample: An automated method and apparatus for separating and harvesting cells of interest, e.g., mononuclear cells, in a whole blood sample. The method of the invention uses the aspirating/dispensing probe of an automated sample preparation instrument to underlay a density gradient medium beneath a whole blood sample in a centrifugation tube,... Agent: Beckman Coulter, Inc.

20080233556 - Cytotonic protein and utlization thereof: This invention provides a cytotoxic protein (M toxin) produced by Helicobacter pylori, a partial peptide, and an antitumor agent containing the cytotoxic protein. The protein is obtained by culturing a transformant which is transformed with a recombination vector containing DNA coding the cytotoxin protein. This invention provides further the use... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080233555 - Homogeneous assay for enzymatic activity: An assay is disclosed for measuring activity of enzymes, such as kinases, phosphatases, and proteses. Measurements of enzymatic activity are accomplished in a homogenous assay format utilizing a fluorescence quenching technique employing paramagnetic metal ions.... Agent: Thompson Hine L.L.P. Intellectual Property Group

20080233560 - Dna-transfection system for the generation of infectious influenza virus: The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system may be used to synthesize any RNA virus, preferably viruses with a negative single stranded RNA genome.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080233559 - Inhibition of hiv-1 replication by disruption of the processing of the viral capsid-spacer peptide 1 protein: Inhibition of HIV-1 replication by disrupting the processing of the viral Gag capsid (CA) protein (p24) from the CA-spacer peptide 1 (SP1) protein precursor (p25) is disclosed. Amino acid sequences containing a mutation in the Gag p25 protein, with the mutation resulting in a decrease in the inhibition of processing... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080233558 - Inhibitors of viral entry screening method: In one aspect the invention relates to a method for identifying inhibitors or viral entry comprising providing an indicator cell wherein said cell expresses a reporter gene and wherein said cell is capable of supporting entry by an effector particle, providing a candidate inhibitor of viral entry, co-compartmentalizing said candidate... Agent: Edwards Angell Palmer & Dodge LLP

20080233561 - Method for measuring cytopathic effect due to viral infection in cells using electric cell-substrate impedance sensing: A method of measuring cytopathic effect in cells includes providing cells in culture, using electric cell-substrate impedance sensing (ECIS) to measure the resistance of current associated with the cells, and quantifying the cytopathic effect (CPE) associated with the cells based on the measured resistance. The cells may be identified as... Agent: Stites & Harbison, PLLC

20080233557 - Pna probes, kits, and methods for detecting lamivudine-resistant hepatitis b viruses: Disclosed are peptide nucleic acid (PNA) probes to detect lamivudine resistant mutants of hepatitis B virus (HBV), which causes acute and chronic hepatitis, kits for detecting lamivudine resistant HBV comprising the PNA probes, and methods for detecting lamivudine resistant HBV by using the kits. They can accurately detect mutations of... Agent: The Webb Law Firm, P.C.

20080233588 - Analytical method and kit: Analytical methods using RNA-containing probes for the detection or analysis of nucleic acid sequences is described. These probes are contacted with a sample suspected of containing the nucleic acid sequence and if they form duplexes, they are hydrolysed. This may be done, for example during an amplification reaction. AMP generated... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080233592 - Assay method for group transfer reactions: The present invention relates to methods for detecting, quantifying and high throughput screening of donor-products and the catalytic activities generating the donor-products in group-transfer reactions catalyzed by adenosine triphosphatase (ATPase) or guanine triphosphatase (GTPase). The invention further provides immunoassays, antibodies and kits that may be used to practice the methods... Agent: Quarles & Brady LLP

20080233583 - Biomarkers for preeclampsia: The present invention provides methods for predicting the development of and diagnosing preeclampsia, providing a prognosis, and predicting recurrence of the disease using molecular markers that are overexpressed or underexpressed in preeclampia. Also provided are methods to identify compounds that are useful for the treatment or prevention of preeclampsia.... Agent: Townsend And Townsend And Crew, LLP

20080233567 - Companion diagnostic assays for cancer therapy: A method for classifying cancer patients as eligible to receive cancer therapy with a small molecule inhibitor of Bcl-2 comprising determination of the presence or absence in a patient tissue sample of chromosomal copy number status at the chromosomal locus 13q14 comprising the microRNA's miR15a and miR16-1. The classification of... Agent: Vysis, Inc Patent Department

20080233589 - Complementation systems utilizing complexes of heteroproteins: The present invention provides heterologous complementation systems and methods of using the systems to detect molecular interactions. In particular, the heterologous complementation systems comprise polypeptide fragments derived from heterologous polypeptides. If a molecular interaction occurs, then the heterologous polypeptide fragments are able to associate and produce a detectable signal.... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080233568 - Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays: This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA, and to those methods of detecting and... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080233569 - Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays: This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA, and to those methods of detecting and... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080233590 - Device for the analysis of liquid samples: The present invention relates to devices for the analysis of liquid samples, comprising a rotational-symmetric rotor (1) which is insertable into a sample container (11), wherein an annular gap (32) is provided between the sample container (11) and the rotor (1), and the rotor (1) has at least one flow... Agent: Fulbright & Jaworski L.L.P.

20080233563 - Enhanced detection of rna using a panel of truncated gene-specific primers for reverse transcription: The present invention provides truncated gene-specific primers in panels that can be used during the reverse transcription step of RT-PCR to increase signal detection of cancer gene markers in a tissue sample. Also provided are forward and reverse primers for RT-PCR. Methods of using the primers are also provided.... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20080233573 - Gene expression profiling for identification, monitoring and treatment of transplant rejection: The present invention provides methods of characterizing organ transplant rejection or inflammatory conditions associated with organ transplant rejection using gene expression profiling.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080233581 - Histone deacetylase and methods of use thereof: The present invention provides nucleic acid molecules that encode histone deacetylase, as well as recombinant vectors and host cells that include the subject nucleic acid molecules. Also provided are histone deacetylase polypeptide compositions. The histone deacteylase nucleic acid molecules are useful in a variety of diagnostic and therapeutic applications, which... Agent: Bozicevic, Field & Francis LLP

20080233574 - Map-based genome mining method for identifying regulatory loci controlling the level of gene transcripts and products: The invention pertains to a method for identifying one or more regions within a genome of an organism of interest that mediate the expression of one or more genes of interest. The method comprises identifying a first and a second organism of interest, the first organism of interest is characterized... Agent: Quarles & Brady LLP

20080233591 - Method and test kit for quantitative determination of polynucleotides in a mixture: The invention relates to a method and test kit for quantitative determination of the amounts or relative proportions of polynucleotides in a mixture. The invention enables assessment of dynamic variations in a mixed population of organisms using affinity aided solution hybridization. The test kit comprises organized pools of polynucleotide probes... Agent: Arent Fox LLP

20080233578 - Method for detecting mutation of nucleic acid using single-stranded dna-binding protein: A method for judging the presence or absence of a mutation in a nucleic acid sequence, the method includes utilizing a single-stranded DNA-binding protein; the aforementioned method for judging the presence or absence of a mutation in a nucleic acid sequence, wherein the aforementioned presence or absence of a mutation... Agent: Birch Stewart Kolasch & Birch

20080233587 - Method for direct amplification from crude nucleic acid samples: The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the direct amplification of the nucleic acids in a crude sample with minimal sample purification.... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080233576 - Method for feature selection in a support vector machine using feature ranking: In a pre-processing step prior to training a learning machine, pre-processing includes reducing the quantity of features to be processed using feature selection methods selected from the group consisting of recursive feature elimination (RFE), minimizing the number of non-zero parameters of the system (l0-norm minimization), evaluation of cost function to... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20080233571 - Method for identifying compounds which affect synaptogenesis: A method is provided for identifying a compound which affects the formation of AMPA receptors into aggregates. A method is also provided for identifying a compound which affects the formation of synaptic connections. A method is provided for identifying a compound that modulates immediate early gene expression. A method is... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP

20080233577 - Method for producing ligands, ligands and test kit: The invention relates to a method for producing ligands, in particular aptamers. With this method, a target substance is offered to a set of candidate ligands, and the unbonded ligands are separated out by a cross-flow filtration process. The retentate, which contains ligand-target substance complexes, then undergoes further continuous cross-flow... Agent: Fleit Gibbons Gutman Bongini & Bianco P.l.

20080233572 - Methods and compositions for the detection and quantification of e.coli and enterococcus: The present invention is drawn to methods and compositions for the rapid assessment of fecal indicator bacteria in a sample. Provided herein are novel primer and probe compositions for use in detecting the presence of these organisms in a sample, particularly using quantitative PCR methods. Provided herein are novel oligonucleotide... Agent: Alston & Bird LLP

20080233566 - Methods and materials for detecting mutations in quasispecies having length polymorphisms: The present invention is directed to a method for detecting the presence or absence of a mutation of interest in the nucleic acid of a pathogen, wherein the mutation of interest is located adjacent to a length polymorphism defining multiple quasispecies of the pathogen.... Agent: Siemens Corporation Intellectual Property Department

20080233570 - Methods for identification of sepsis-causing bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of sepsis-causing bacteria by molecular mass and base composition analysis.... Agent: Casimir Jones, S.c.

20080233575 - Methods for increasing accuracy of nucleic scid sequencing: The invention provides methods for improving the fidelity of a sequencing-by-synthesis reaction by resequencing at least a portion of a nucleic acid template.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080233586 - Methods for preparing and preforming analysis: The invention relates to methods for preparing and performing quantitative PCR analyses, a new sealing device and a new use. According to the invention, a sample vessel containing the samples to be analyzed is sealed by placing a planar sealing device on the vessel to cover the samples and applying... Agent: Birch Stewart Kolasch & Birch

20080233565 - Pkhdl1, a homolog of the autosomal recessive kidney disease gene: Nucleic acids encoding fibrocystin-L polypeptides and fibrocystin-L polypeptides are provided. Antibodies against the polypeptides, vectors and host cells containing the nucleic acids, methods for using the nucleic acids and polypeptides, and compositions and articles of manufacture also are provided.... Agent: Fish & Richardson P.C.

20080233579 - Primer set for detecting overexpression of katp channel and kit comprising said primer set: The present invention relates to a primer set for confirming an increase of mRNA in an ATP-sensitive potassium channel (KATP channel)(Kir6.1) having an effect of protecting heart from hypoxia or an ischemic disease; a kit including the primer set; and a method of identifying an agent for treating an ischemic... Agent: Christie, Parker & Hale, LLP

20080233593 - Pseudo-tissue for quality control and quality control method using same: A pseudo-tissue for quality control is described, which includes a nucleic acid component selected from the group consisting of a nucleic acid and a cell including a nucleic acid, and a gel for holding nucleic acid component.... Agent: Sughrue Mion, PLLC

20080233584 - Rnai modulation of mll-af4 and uses thereof: The invention relates to compositions and methods for modulating the expression of the MLL-AF4 fusion gene, and more particularly to the downregulation of MLL-AF4 by chemically modified oligonucleotides.... Agent: Lowrie, Lando & Anastasi, LLP A2038

20080233582 - Single nucleotide polymorphisms associated with susceptibility to cardiovascular disease: The present invention provides SNPs, polymorphic variants, and haplotypes associated with cardiovascular disease. The invention also provides methods for detecting the SNPs, polymorphic variants, and haplotypes. The invention also provides methods for determining an individual's genotype with respect to one or more polymorphisms and/or haplotypes associated with cardiovascular disease. The... Agent: Siemens Corporation Intellectual Property Department

20080233580 - Transgenic animal model: The present invention is related to a transgenic, non-human animal, particularly a transgenic rodent, but especially a transgenic mouse model which allows for the simultaneous, tissue-specific and temporally-controlled regulation of transgene expression and can be used as a tool to investigate the consecutive steps involved in initiation and progression of... Agent: Buchanan, Ingersoll & Rooney PC

20080233585 - Use of differentially expressed nucleic acid sequences as biomarkers for cancer: The present invention relates to novel marker sequences that are differentially expressed in cancer cells or tissue of a subject with cancerous conditions. The present invention also relates to assays for diagnosis, prognosis, staging, monitoring, therapeutic treatment, and marker sequence related agents including probes, primers, antibodies, and therapeutic compositions.... Agent: Siemens Corporation Intellectual Property Department

20080233596 - Chimeric human t1r1 taste receptor polypeptides and compositions containing same: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department

20080233594 - Method for detecting an at least bivalent analyte using two affinity reactants: A method for the determination of an analyte which is a) present in a liquid sample 1 suspected of containing the analyte, and b) at least bivalent with respect to simultaneous affinity binding of at least two binding structures BSs. The method comprises formation of an affinity complex that comprises... Agent: Fulbright & Jaworski, LLP

20080233595 - Method for diagnosing intertility: The invention relates to methods for diagnosing conditions characterized by altered expression of a pregnancy related serine protease (PRSP) protein in a mammal. Such conditions include infertility caused by an inability to achieve or sustain embryo implantation, an inability to sustain a pregnancy, early abortion, insufficient placentation, pre-eclampsia, or intrauterine... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080233598 - Nucleic acid and corresponding protein entitled 121p2a3 useful in treatment and detection of cancer: A novel gene (designated 121P2A3) and its encoded protein, and variants thereof, are described wherein 121P2A3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 121P2A3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 121P2A3 gene... Agent: Agensys C/o Morrison & Foerster LLP

20080233599 - Immunogenic glycopeptides, screening, preparation and uses: The invention concerns immunogenic glycopeptides derived from pathogenic microorganisms, useful for vaccination and diagnosis of infections caused by said pathogenic microorganisms (bacteria or fungi), and methods for selecting them and preparing them. Said glycopeptides are selected in the group consisting of: a1) glycopeptides essentially consisting of a glycosylated T epitope,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080233597 - Method of detecting or differentiating rheumatoid arthritis and method of determining stage of disease or degree of dysfunction with regard to rheumatoid arthritis: The detection and differentiation of rheumatoid arthritis are performed by measuring the levels of L-PGDS in a sample such as a body fluid such that the measurement value is used as an index. Further, the stage of disease or the degree of dysfunction of a rheumatoid arthritis patient is determined... Agent: Greenblum & Bernstein, P.L.C

20080233600 - Method and kit for the measurement of neutrophil cell activation: The present invention is related to accurate detection methods for the measurement only of myelopexidase (MPO) levels or neutrophils, preferably equine neutrophils, in complex biological samples. The present invention is further related to ELISA and SIEFED assays for such detection. SIEFED detection sensitivity of active peroxidase activity was found to... Agent: Fitch Even Tabin And Flannery

20080233601 - Polymerizable chemiluminescent compounds: wherein R1 is selected from the group consisting of hydrogen, C1-C6 alkyl, amino, N-C1-C6-alkylamino, and N,N—C1-C6-dialkylamino; and ring “A” is selected from the group consisting of unsubstituted or substituted C4-C8-cycloalkenyl, unsubstituted or substituted bicyclo [2,2,1]alkenyl, and unsubstituted or substituted bicyclo [2,2,2]alkenyl, unsubstituted phenyl, and phenyl substituted with a moiety selected... Agent: Dewitt Ross & Stevens S.c. Intellectual Property Department

20080233602 - Detecting and profiling molecular complexes: Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first protein in a complex and one or more binding compounds specific for one or more second proteins... Agent: Monogram/fenwick

20080233603 - Fluorine nmr spectroscopy for biochemical screening: High-Throughput Screening (HTS) of large compound libraries is the method of drug-lead discovery. It is now well accepted that for a functional assay, quality is more important than quantity. A biochemical NMR method originally proposed by Percival and Withers (Biochemistry, 1992, 31, 498-505) is extended to the screening of Ser/Thr... Agent: Peter I. Bernstein Scully, Scott, Murphy & Presser

20080233604 - Methods for identifying compounds capable of modulating the hydrolase activity of clca protein: Methods for identifying compounds capable of modulating the hydrolase activity of a CLCA protein include screening and computer modelling methods. The compounds, including antibodies, may be useful as therapeutic agents to treat a variety of diseases.... Agent: Fish & Richardson P.C.

20080233605 - Method of assaying glycated protein: The invention is directed to a method for reducing the effect of a fructosyl lysine compound in an assay of fructosyl peptide or fructosyl amino acid contained in a sample, characterized by including causing an enzyme for assaying fructosyl peptide or fructosyl amino acid to act specifically on fructosyl peptide... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080233606 - Use of raman spectroscopy in enzyme activity assays: Provided herein are assays for detecting enzyme activity using Raman Spectroscopy.... Agent: Wilson Sonsini Goodrich & Rosati

20080233607 - Cell culture device: The invention provides cell culture devices comprising a channel, the channel comprising one or more inlets and one or more outlets, and a cell retention chamber defined by an internal surface of the channel and a plurality of projections extending therefrom. The invention further provides methods of use relating to... Agent: Klarquist Sparkman, LLP

20080233608 - Genes and proteins involved in lipid remodeling of gpi-anchored proteins and the use thereof: This invention provides proteins and genes thereof involved in the GPI lipid remodeling process and, thereby and constructing a system for screening for useful substances such as anticancer agents and a system for detecting abnormalities in the GPI lipid remodeling process.... Agent: Foley And Lardner LLP Suite 500

20080233610 - Somatic cell reprogramming: The present invention relates to methods for reprogramming a somatic cell to pluripotency by administering into the somatic cell at least one or a plurality of potency-determining factors. The invention also relates to pluripotent cell populations obtained using a reprogramming method.... Agent: Quarles & Brady LLP

20080233609 - Spirolactam targeting compounds and related compounds: Spirolactam targeting compounds, related compounds, uses of such compounds, and methods of making such compounds are disclosed.... Agent: Fish & Richardson PC

20080233611 - Orthogonal translation components for the in vivo incorporation of unnatural amino acids: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases,... Agent: Quine Intellectual Property Law Group, P.C.

20080233612 - Fungal hosts for expression of recombinant products: An isolated mutant Ophiostoma species having enhanced protein excretion capability as compared with its parent strain cultured under similar conditions.... Agent: Barnes & Thornburg LLP

20080233615 - Nucleic acid encoding two-component sensing and regulatory proteins, antimicrobial proteins and uses therefor: Stress-related nucleic acid molecules and polypeptides and fragments and variants thereof are disclosed in the current invention. In addition, stress-related fusion proteins, antigenic peptides, and anti-stress-related antibodies are encompassed. The invention also provides recombinant expression vectors containing a nucleic acid molecule of the invention and cells into which the expression... Agent: Alston & Bird LLP

20080233613 - Polypeptides having beta-glucosidase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes, Inc.

20080233614 - Production of recombinant collagenases colg and colh in escherichia coli: The present invention provides codon-optimized genes designed to help maximize heterologous protein expression level. The present invention provides codon-optimized recombinant colG and colH collagenase sequences.... Agent: Elmore Patent Law Group, PC

20080233616 - Method for carrying out the selective evolution of proteins in vitro: The present invention relates to the production of variants of a protein in an in vitro evolution method, comprising the steps: (A) provision of an in vitro expression system comprising (i) a nucleic acid sequence S which codes for a protein Y which is to be varied, (ii) a target... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080233562 - Method of estimating antitumor effect of histone deacetylase inhibitor: The present invention provides a method of obtaining a gene capable of becoming an index for predicting the efficacy of a histone deacetylase inhibitor, which comprises at least (I) a step of dividing tumor cells into a histone deacetylase inhibitor sensitive tumor cell and a histone deacetylase inhibitor resistant tumor... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080233564 - Methods of using databases to greate gene-expression microarrays, microarrays greated thereby, and uses of the microarrays: Methods of preparing biological databases, and databases prepared according to those methods. In some embodiments, the methods can be performed entirely using computer resources, relying solely on publicly available biological sequence information. The methods of the invention can be used to generate species-specific nucleic acid microarrays... Agent: Calfee Halter & Griswold, LLP

20080233617 - Process for the preparation of a aspartate and derived amino acids like lysine, threonine, isoleucine, methionine, or homoserine employing microorganism with enhanced isocitrate lyase and/or malate synthase expression: The present invention relates to increasing the product of aspartate or aspartate-derived metabolites by boosting the activity of the glyoxylate shunt. This is accomplished by increasing the activity of glyoxylate shunt specific enzymes and decreasing the activity of reactions consuming glyoxylate and its precursors.... Agent: Bozicevic, Field & Francis LLP

20080233618 - Biosynthetic gene cluster for leptomycins: Polypeptides and domains of leptomycin polyketide synthase and the nucleic acids encoding them are provided. Methods to prepare leptomycin, leptomycin analogs, and leptomycin derivatives are described, as are methods to prepare other polyketides using the nucleic acids encoding leptomycin polyketide synthase domains or modifying enzymes.... Agent: Bristol-myer Squibb Company

20080233619 - Process for the enantioselective enzymatic reduction of keto compounds: The present invention relates to a process for the enantioselective enzymatic reduction of keto compounds which is carried out in two phases and uses 4-methyl-2-pentanol, 5-methyl-2-hexanol and/or 2-heptanol for coenzyme regeneration.... Agent: Workman Nydegger

20080233620 - Novel transformant and process for producing polyester using the same: In the present invention, yeast in which a plurality of genes is disrupted is produced using the homologous recombination. Moreover, a transformant is obtained by introducing a plurality of enzyme genes involved with polyhydroxyalkanoic acid synthesis such as a polyhydroxyalkanoic acid synthase gene and an acetoacetyl CoA reductase gene into... Agent: Sughrue Mion, PLLC

20080233621 - Method for producing alcohol and carboxylic acid having optical activity: It is an object of the present invention to provide an inexpensive and efficient industrial method for obtaining (S)-2-pentanol, (S)-2-hexanol, 1-methylalkyl malonic acid and 3-methyl carboxylic acid at a high optical purity. The present invention provides a method of producing (S)-2-pentanol or (S)-2-hexanol which comprises allowing certain types of microorganisms... Agent: Greenblum & Bernstein, P.L.C

20080233622 - Novel methods for production of 5-epi-beta-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one, and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one: The present invention is directed to novel methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. In one embodiment the present invention describes a method for production of 5-epi-β-vetivone by the use of premnaspirodiene as starting material. In another embodiment the present invention describes... Agent: Catalyst Law Group, Apc

20080233623 - Genetically modified host cells for increased p450 activity levels and methods of use thereof: The present invention provides genetically modified host cells that exhibit modified activity levels of one or more gene products such that, when a cytochrome P450 enzyme is produced in the genetically modified host cell, the modified activity levels of the one or more gene products provide for enhanced production and/or... Agent: Bozicevic, Field & Francis LLP

20080233624 - Apparatus and method for biohydrogen production: An apparatus for biohydrogen production comprises a cell with an anion-selective membrane dividing the cell into first and second compartments. In use, the first compartment is placed into fluid communication with a bacterial fermentation culture and the second compartment is placed into fluid communication with a photoheterotrophic bacterial culture. Application... Agent: Berliner & Associates

20080233625 - Dietary supplements for regulating the central nervous system: Compositions comprising a plurality of yeast cells, wherein said plurality of yeast cells have been cultured in the presence of an alternating electric field having a specific frequency and a specific field strength for a period of time sufficient to increase the capability of said plurality of yeast cells to... Agent: Ropes & Gray LLP

20080233626 - Enhanced broad-spectrum uv radiation filters and methods: The present invention obtains from the discovery that combining traditional UV pigments, organic chemicals, or both, combined with NA, creates a broad spectrum UV absorbing additive that is much more efficient than using any of the ingredients by themselves. Methods for producing NA-coated particles as a UV protection additive to... Agent: Charles J. Prescott, P.A.

20080233629 - Enzymes for biopolymer production: In order to optimize the flux or flow of carbon intermediates from normal cellular metabolism into PHAs it is desirable to optimize the expression of the enzymes of the PHA biosynthetic pathway. Gene fusions are genetic constructs where two open reading frames have been fused into one and encode hybrid... Agent: Patrea L. Pabst Pabst Patent Group LLP

20080233628 - Incorporation of type iii polyketide synthases into multidomain proteins of the type i and iii polyketide synthase and fatty acid synthase families: Recombinant fusion proteins in which intermediates are covalently bound to the fusion proteins and transferred between domains of the fusion proteins are provided. The fusion proteins include proteins having type I polyketide or fatty acid synthase domains fused with type III polyketide synthase domains. Methods of making such recombinant fusion... Agent: Quine Intellectual Property Law Group, P.C.

20080233627 - Nicotianamine synthase and gene encoding the same: A nicotianamine synthase is isolated and purified. Then the gene of this enzyme is cloned and the base sequence and amino acid sequence thereof are determined. This gene is employed in constructing plants, in particular, grass plants highly tolerant to iron-deficiency. A nicotianamine synthase involved in the mugineic acid biosynthesis... Agent: Edwards Angell Palmer & Dodge LLP

20080233630 - Apparatus and method for magnetically separating cells from mixture: According to the conventional process of separating necessary cells from a cell mixture containing specific cells tagged with magnetic beads, there is a problem in that separation process is complicated when the separation efficiency is high whereas the separation efficiency is relatively low when the separation process is simplified. The... Agent: Lowe Hauptman Ham & Berner, LLP

20080233631 - Ventilating/stirring culture tank: The invention provides a ventilating/stirring culture tank that has a longitudinal tubular container 2 that is capable of freely containing culture fluid, within which a rotation shaft 3 that is supported coaxially with the axis of the container 2, a stirring impeller 4 that is attached to the rotation shaft... Agent: Drinker Biddle & Reath (dc)

20080233632 - Process for labeling and purification of nucleic acids of interest present in a biological sample to be treated in a single reaction vessel: e

20080233633 - Sheathing for packaging a predetermined volume of a biological substance designed to be immersed in a liquid cryogenic agent: The invention concerns a sheathing for packaging a predetermined volume of a biological substance designed to be immersed in a liquid cryogenic agent comprising a thin tube (6), characterized in that it further comprises a ballast (24) associated with said thin tube (6).... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080233635 - Methods and apparatus for high purity x-chromosome bearing and y-chromosome bearing populations of spermatozoa: Isolated non-naturally occurring populations of spermatozoa (15) having high purity and technologies to differentiate spermatozoa (28) based on characteristics such as mass, volume, orientation, or emitted light including methods of analysis and apparatus such as beam shaping optics (30) and detectors (32).... Agent: Santangelo Law Offices, P.C.

20080233634 - Nucleic acid detection device: A nucleic acid detection device is provided with a closed channel formed of a first channel portion, through which a washing reagent storage section for storing a washing reagent for washing a detection section for nucleic acid detection communicates with the detection section, and a second channel portion through which... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080233636 - Humidity-controlled gas-borne matter collection device: A system includes a device for collecting gas-borne matter therein and a humectant provided external to the device for maintaining a desired humidity level for collected matter in the device.... Agent: Foley & Lardner LLP

20080233637 - Melanoma antigens and their use in diagnostic and therapeutic methods: The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognoses a mammal afflicted with melanoma or metastata melanoma. This invention... Agent: Leydig, Voit & Mayer, Ltd.

20080233638 - Paad domain-containing polypeptides, encoding nucleic acids, and methods of use: The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NACHT domains and ARED domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that... Agent: Mcdermott, Will & Emery

20080233639 - Fusion protein delivery system and uses thereof: The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present... Agent: Bradley Arant Rose & White, LLP Intellectual Property Department-nwj

20080233640 - Prostate stem cell: We describe a method for the isolation of prostate stem cells, typically prostate stem cells which express CD 133 antigen; stem cells and cancer stem cells isolated by the method and their use.... Agent: Crowell & Moring LLP Intellectual Property Group

20080233641 - Simultaneous modulation of multiple genes: Disclosed herein are compositions and methods that regulate expression of two or more endogenous genes.... Agent: Robins & Pasternak

20080233642 - Mammalian immortalized liver cell: The present invention provides a mammalian immortalized liver cell obtained by transferring a cell proliferation factor gene located between a pair of site-specific recombination sequences into a mammalian liver cell.... Agent: Kratz, Quintos & Hanson, LLP

20080233643 - Differentiation of cd34 positive cell to megakaryocyte and multiplication: An object of the present invention is to provide a method for more efficiently differentiating CD34+ cells derived from umbilical cord blood into megakaryocytic lineage cells and for generating platelets. Coculture of CD34+ cells derived from umbilical cord blood with immortalized stromal cells in the presence of cytokines has enabled... Agent: Foley And Lardner LLP Suite 500

20080233644 - Chimeric transcription factor decoy oligonucleotides: A method for the treatment of the brain cancer glioblastoma multiforme (GBM) is provided. The method involves decreasing the expression of Matrix Metalloproteinase-1 (MMP-1) expression by providing transcription factor decoy nucleotides that mimic single nucleotide polymorphisms responsible for MMP-1 overexpression.... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20080233646 - Human dr4 antibodies and uses thereof: Human Death Receptor 4 (DR4) antibodies are provided. The human DR4 antibodies may be included in pharmaceutical compositions, articles of manufacture, or kits. Methods of treatment and diagnosis using the DR4 antibodies are also provided.... Agent: Genentech, Inc.

20080233645 - Methods and compositions of ig20 and denn-sv splice variants: Methods and compositions relating to IG20 expression, splice variants of IG20, effects of endogenous DENN-SV function with respect to processes regulating cell proliferation, cell survival and cell death are disclosed.... Agent: Barnes & Thornburg LLP

20080233647 - Novel neurotrophic factors: The invention relates to neublastin neurotrophic factor polypeptides, nucleic acids encoding neublastin polypeptides, and antibodies that bind specifically to neublastin polypeptides, as well as methods of making and methods of using the same.... Agent: Fish & Richardson PC

20080233648 - Biasing of cells toward retinal, corneal or lens development: Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells or mesenchymal stem cells are transfected... Agent: Beusse Wolter Sanks Mora & Maire

20080233649 - Pancreatic stem cells: Pancreatic progenitor cells isolated from the pancreas of a mammal. The invention also includes pancreatic cells or neural cells differentiated from the pancreatic progenitor cells.... Agent: Bereskin And Parr

20080233650 - Method for propagating adenoviral vectors encoding inhibitory gene products: The invention provides a method of propagating an adenoviral vector. The method comprises (a) providing a cell comprising a cellular genome comprising a nucleic acid sequence encoding a tetracycline operon repressor protein (tetR), and (b) contacting the cell with an adenoviral vector comprising a heterologous nucleic acid sequence encoding a... Agent: Leydig Voit & Mayer, Ltd

20080233651 - Method and medicament for inhibiting the expression of a given gene: The present invention relates to the specific inhibition of expression of a target gene in mammals using a short double stranded RNA. The dsRNA is less than 49 nucleotides in length and has a nucleotide sequence which is complementary to at least a part of the target gene. The dsRNAs... Agent: Lowrie, Lando & Anastasi, LLP A2038

20080227081 - Process for decomposing hydrogen sulfide by means of feeding oxygen: A process is provided for decomposing hydrogen sulfide in a biogas fermenter (10) for generating biogas from biomass, which is fed as a fermentation substrate into the biogas fermenter (10). A reaction gas with increased oxygen content compared to air is fed into a gas space (26) of the biogas... Agent: Mcglew & Tuttle, PC

20080227082 - Method of identifying a mhc class i restricted t cell response: Described are peptides and polypeptides derived from the MUC-1 polypeptide which are able to activate Cytotoxic T Lymphocyte (CTL) response, analogues of such peptides and polypeptides nucleotide sequences encoding such peptides and polypeptides and therapeutic uses thereof. Moreover, indications for selecting appropriate minimal antigenic MUC-1 polypeptides with reference to the... Agent: Buchanan, Ingersoll & Rooney PC

20080227083 - Optical detector for enzyme activation: Activation of an enzyme in a bodily fluid is detected based on the amount of cleavage of a substrate for the enzyme. The substrate is tagged with two fluorescent dyes—a donor and an acceptor. The tagged substrate is presented to the bodily fluid. A device emits energy at a first... Agent: Medtronic, Inc.

20080227084 - Analysis of hiv-1 coreceptor use in the clinical care of hiv-1-infected patients: A change in viral tropism occurs in many HIV positive individuals over time and can be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations... Agent: Frommer Lawrence & Haug

20080227088 - Approaches to identify less harmful tobacco and tobacco products: Aspects of the invention concern methods for detecting, identifying and evaluating tobacco and tobacco products to determine the potential that these compositions have to contribute to a tobacco-related disease. It is based, at least in part; on the discovery that exposure of pulmonary cells to smoke or smoke condensate obtained... Agent: Knobbe Martens Olson & Bear LLP

20080227096 - Assay for response to proteasome inhibitors: The invention relates to a method for predicting a response to a proteasome inhibitor in the prophylaxis or treatment of a cancer in an individual. The method comprises providing a sample of cancer cells of the cancer from the individual, and evaluating the level of at least one molecule in... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080227099 - Compositions and methods for increasing cholesterol efflux and raising hdl using atp binding cassette transporter protein abc1: The present invention relates to novel ABC1 polypeptides and nucleic acid molecules encoding the same. The invention also relates to recombinant vectors, host cells, and compositions comprising ABC1 polynucleotides, as well as to methods for producing ABC1 polypeptides. The invention also relates to antibodies that bind specifically to ABC1 polypeptides.... Agent: Cv Therapeutics, Inc.

20080227107 - Compositions and methods for labeling of nucleic acid molecules: The present invention is generally related to compositions, kits and methods for labeling nucleic acid molecules using reverse transcriptases, preferably multi-subunit reverse transcriptases such as ASLV reverse transcriptases. Specifically, the invention relates to methods, kits and compositions for fluorescently labeling nucleic acid molecules during nucleic acid synthesis. The labeled nucleic... Agent: Invitrogen Corporation C/o Intellevate

20080227106 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Goodwin Procter LLP Attn: Patent Administrator

20080227097 - Fluorescent protein and chromoprotein: It is an object of the present invention to provide a novel chromoprotein and a novel fluorescent protein. The present invention provides chromoproteins derived from Anthopleura inornata, which have certain property, and fluorescent proteins from Trachyphyllia geoffroyi and Scolymia vitiensis, which have certain fluorescent property.... Agent: Greenblum & Bernstein, P.L.C

20080227098 - Method for diagnosing cancer of the prostate: Methods for diagnosis and prognosis of prostate cancer are provided. The methods involve the detection of the level of expression of Claudin-1 in tissue or cell samples. Claudin-1 is underexpressed or non-expressed in the majority of prostate cancers.... Agent: Knobbe Martens Olson & Bear LLP

20080227105 - Method for diagnosing diseases: An improved method for diagnosing autoimmune or genetic diseases is provided in this disclosure. In particular, a method to diagnose diseases affecting the tissues of organs selected from the group of spleen, brain, heart, kidney, thyroid, eye, skin, intestine, liver, pancreas, adrenal gland, prostate and lungs or from the tissues... Agent: Dodds & Associates

20080227100 - Method for estimating herg inhibition of drug candidates using multivariate property and pharmacophore sar: The present invention provides a computational model and methods of use thereof for predicting whether a compound is likely to inhibit K+ flow through the hERG ion channel. Methods for in silico screening of compounds that have a lower likelihood of inhibiting hERG are also provided.... Agent: Louis J. Wille Bristol-myers Squibb Company

20080227103 - Method for identification of polynucleotides capable of cleaving target mrna sequences: Provided are methods for identifying a polynucleotide that can reduce the level of a target mRNA. The method can be performed by providing cells that express an RNA polynucleotide that contains a target mRNA sequence, an internal ribosome entry sequence (IRES) and a sequence encoding a secreted reporter protein; introducing... Agent: Hodgson Russ LLP The Guaranty Building

20080227089 - Method of diagnosing and/or predicting the development of an allergic disorder: The present invention relates to methods for diagnosing an allergic disorder, predicting the development of an allergic disorder in an animal, monitoring the progress of therapy targeted at an allergic disorder, classification of the allergic disorder into one or more clinical/immunological phenotypes, and/or determining the potentional responsiveness of individual animals... Agent: Schwegman, Lundberg & Woessner, P.A.

20080227094 - Method of judging lymph node metastasis of stomach cancer: Methods of judging the lymph node metastasis of stomach cancer, apparatuses for judging the lymph node metastasis of stomach cancer and kits used therefor are disclosed.... Agent: Sughrue Mion, PLLC

20080227085 - Methods and systems for the identification of rna regulatory sequences and compounds that modulate their function: The present invention is directed to a non-cell based method for identifying RNA regulatory sequences involved in translational control. The method includes: combining a translational extract; an RNA test sequence; and a reporter mRNA under suitable conditions for translation of the reporter mRNA. The method also includes measuring the effect... Agent: Hoffmann & Baron, LLP

20080227102 - Methods for identification of merle gene: Animals with mutations in SILV present with the merle coat color pattern phenotype. Methods for the identification of animals that harbor a mutation in the SILV gene are described. Mutations in the SILV gene can be identified from any biological sample such as a cell or tissue that contains genomic... Agent: Patrea L. Pabst Pabst Patent Group LLP

20080227101 - Methods for testing milk: The disclosure is related generally to methods for testing mammary fluid (including milk) to establish or confirm the identity of the donor of the mammary fluid. Such methods are useful in the milk-bank business to improve safety.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080227090 - Methods, apparatus, and computer programs for verifying the integrity of a probe: The present invention provides methods, apparatuses and computer programs for verifying the integrity of a probe by comparing the fluorescence value of a probe to a threshold value. The invention also provides for methods, apparatuses and computer programs for normalizing the fluorescence value of a probe and detecting a target... Agent: Townsend And Townsend And Crew, LLP

20080227108 - Molecular identification of aspergillus species: Novel techniques for the detection of Aspergillus in samples are disclosed. These techniques relate to PCR amplification and/or detection of Aspergillus ITS1 rDNA sequences, and the identification of particular species of Aspergillus by detecting differences in the ITS1-V1, ITS-V2, ITS-V3, ITS-V4, and ITS-V5 nucleic acid sequences of Aspergillus. The highly... Agent: Klarquist Sparkman, LLP

20080227093 - Phenylthiocarbamide (ptc) taste receptor: The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC... Agent: Klarquist Sparkman, LLP

20080227104 - Primer, primer set, and nucleic acid amplification method and mutation detection method using the same: where B is an atomic group having a nucleobase skeleton, E is an atomic group having a deoxyribose skeleton, a ribose skeleton, or a structure derived from either one of them, or an atomic group having a peptide structure or a peptoid structure, and Z11 and Z12 are each an... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20080227091 - Qtl controlling sclerotinia stem rot resistance in soybean: Markers associated with Sclerotinia stem rot resistance are provided. Methods of identifying resistant, and susceptible plants, using the markers are provided. Methods for identifying and isolating QTL are a feature of the invention, as are QTL associated with Sclerotinia stem rot resistance.... Agent: Law Offices Of Jonathan Alan Quine

20080227109 - Risk assessment for adverse drug reactions: The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most... Agent: Occhiuti Rohlicek & Tsao, LLP

20080227087 - Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa) of mrej types xi to xx: Described herein are novel SCCmec right extremity junction (MREJ) sequences for the detection and/or identification of methicillin-resistant Staphylococcus aureus (MRSA). Disclosed are methods and compositions based on DNA sequences for the specific detection of MREJ sequences designated types xi, xii, xiii, xiv, xv, xvi, xvii, xviii, xix, and xx for... Agent: Knobbe Martens Olson & Bear LLP

20080227092 - Solid-phase oligosaccharide tagging: a technique for manipulation of immobilized carbohydrates: The invention relates to methods of manipulating immobilised carbohydrates by derivatisation. Depending on the nature of the derivatisation, the carbohydrate may thereby be more easily detected and/or identified or handled. In particular, the invention relates to methods of preparing a reactive sugar comprising the steps of: i) providing a sample... Agent: Millen, White, Zelano & Branigan, P.C.

20080227095 - Systems and methods of analyzing nucleic acid polymers and related components: Systems and methods of identifying, sequencing and/or detecting nucleic acid polymers, as well as related components (e.g., substrates, software and the like) are disclosed.... Agent: Wolf Greenfield & Sacks, P.C.

20080227086 - Test system and method for the detection of analytes: The invention relates to analytical test systems and analytical methods, in which molecular switches are used for the qualitative and quantitative determination of analytes in a sample, which have a broad application by means of a selection of the molecular switch suitable for the analyte. The molecular switch comprises a... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080227112 - Global polyclonal antibodies, process for depleting commonly shared proteins by same, devices using same: A method for removing abundance proteins from a biological sample comprises passing the biological sample through a support. The support is coated with an avian polyclonal antibody. The avian polyclonal antibody is capable of binding to substantially all proteins in the biological sample with concentrations higher than a predetermined value.... Agent: Brinks Hofer Gilson & Lione

20080227110 - Human genes, sequences and expression products: Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20080227113 - Methods, antibodies and kits for detecting cerebrospinal fluid in a sample: The present disclosure relates to detection of the presence or absence of cerebrospinal fluid (CSF) in a sample, in particular to the analysis of the CSF protein lipocalin-type prostaglandin D2 synthase (L-PGDS). The present disclosure provides assays for the analysis of L-PGDS indicating the presence or absence of CSF in... Agent: Cantor Colburn, LLP

20080227111 - Reagent kit and method for measuring hcv antibody: e

20080227114 - Compositions and methods for modulating c-rel-dependent cytokine production: The present invention is directed to compositions and methods for modulating c-Rel-dependent cytokine production without materially altering the level of expression of NFκB and/or the amount of IκB. The present invention is also directed to screening for modulators of c-Rel activity as determined by assaying for altered subcellular localization of... Agent: Edwards Angell Palmer & Dodge LLP

20080227119 - Elisa for vegf: The vascular endothelial growth factor (VEGF) activity in a patient's bloodstream or other biological sample can serve as a diagnostic and prognostic index for cancer, diabetes, heart conditions, and other pathologies. Antibody-sandwich ELISA methods and kits for VEGF as an antigen are provided to detect types of VEGF levels in... Agent: Genentech, Inc.

20080227120 - Fret-based assay for screening modulators of receptor cycling: Automated FRET imaging of membrane-bound receptor/ligand complexes can discriminate between a clustered organization of ligand/receptor complexes that occurs during the early endocytic stages following internalization and a random distribution characteristic of late stage disassociation of ligand from the receptor. In the case of the low density lipoprotein receptor (LDL-R) and... Agent: Heslin Rothenberg Farley & Mesiti PC

20080227121 - Inducible ligand for alpha1beta1 integrin and uses: The present invention is directed to the identification and use of agents, particularly peptides and monoclonal antibodies that disrupt the interaction between Collagen XIII and α1β1 integrin.... Agent: Mueting, Raasch & Gebhardt, P.A.

20080227118 - Protein immobilization method and quantification method: The present invention relates to a method for immobilizing a protein in a sample, which could not easily be immobilized by the conventional immobilization method, to a solid-phase; a method for quantitative determination of protein wherein an effect of inhibitory substance coexisting in a sample prepared using the immobilization method... Agent: Kratz, Quintos & Hanson, LLP

20080227122 - P2y purinergic receptor expression for identifying preneoplastic and neoplastic states: The present invention relates to methods for identifying pre-neoplastic and neoplastic states in mammals and in particular to a method for identifying pre-neoplasia and neoplasia in cells and tissues based on differential expression of P2Y purineric receptors.... Agent: Townsend And Townsend And Crew, LLP

20080227123 - Methods for specifically selecting antibody-producing cells: Methods are provided for selecting B cells that produce a desired antibody, comprising a step of culturing B cells, which have the properties of cell death being induced under specific conditions and that cell death being suppressed by a signal generated as a result of the binding between an antigen... Agent: Townsend And Townsend And Crew, LLP

20080227116 - Histaminase determination: Disclosed is a method for determining histaminase (DAO; EC 1.4.3.6) activity in a sample. Said method comprises the following steps: an aqueous solution is supplied which contains a predefined amount of a diamine; the aqueous solution is mixed and incubated with the sample for a given period of time in... Agent: Fulbright & Jaworski L.L.P.

20080227115 - Inhibition of cancer metastasis: The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-α (IKKα) and the IKKα-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.... Agent: Medlen & Carroll, LLP Suite 350

20080227124 - Solid phases optimized for chemiluminescent detection: Solid supports for chemiluminescent assays are provided. The solid support includes a plurality of probes covalently or physically attached to the support surface and a chemiluminescent enhancing moiety incorporated onto the surface or into the bulk of the support. The solid support can be a multi-layered support including an upper... Agent: Morris Manning Martin LLP

20080227117 - Peptides as biomarkers of copd: The present invention relates to the identification of biomarkers for the disease condition COPD. The uses of such biomarkers in diagnosis and therapy and a novel method for their identification is are also described.... Agent: Fish & Richardson P.C.

20080227127 - Human nk3-related prostate specific gene-1: The present invention relates to a novel member of the NK family of homeobox genes. In particular, isolated nucleic acid molecules are provided encoding the human NK-3 prostate specific gene 1 (NKX3.1) protein. NKX3.1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same.... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20080227126 - Optical waveguide type antibody chip and method of measuring antigen concentration: An optical waveguide type antibody chip includes a transparent substrate, an incident-side optical element and an emitting-side optical element placed at a distance from each other on a primary face of the substrate, a water repellent resin film formed on the primary face of the substrate including an optical waveguide... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080227125 - Secreted polypeptide species reduced in cardiovascular disorders: The invention discloses human secreted polypeptides that circulate at a decreased level in the plasma of patients with cardiovascular disorders. The invention also provides methods of using compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for these polypeptides, for diagnosis, prognosis, and for drug development.... Agent: Novartis Corporate Intellectual Property

20080227129 - Methods of protein destabilization and uses thereof: This invention is directed towards methods of destabilizing proteins in living cells, and their use for the development of novel assays. In one embodiment, the invention comprises the use of non-cleavable multimerized ubiquitin fusion proteins to destabilize a target protein, such as a reporter moiety. In one aspect of this... Agent: Lisa A. Haile, J.d., Ph.d Dla Piper US LLP

20080227128 - Resonance energy transfer system and method: The present invention relates to a novel BRET system. The BRET system can be used to identify modified recognition sites within a protein insert and to identify the compounds involved in modulation of a given modification. The BRET system of the present invention can also be used in a screening... Agent: Darby & Darby P.C.

20080227130 - Method for detecting exposure to ionizing radiation: A method for detecting exposure to ionizing radiation. An HbA1c test is performed on blood extracted from an animal at a first time, to establish a baseline glycosylated hemoglobin score, and a second HbA1c test is performed on blood extracted from the animal at a second time, to establish a... Agent: Richard A. Wilhelm

20080227131 - Signalling assay and cell line: The invention relates to a sensor for indicating the transduction and inhibition of stress signals through the p38-MAPK pathway in living cells. The sensor comprises a reporter gene product and an isoform of p38 Mitogen Activated Protein Kinase (MAPK). The invention also provides plasmid and viral vectors containing nucleic acids... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20080227132 - Hydrolase enzymes and their use in kinetic resolution: The invention relates to hydrolases and to polypeptides having hydrolase activity. In addition, the invention relates to the use of these hydrolase enzymes in kinetic resolution.... Agent: Verenium Corporation Intellectual Property Department

20080227133 - Kpni restriction endonucleases with reduced star activity: Methods are provided for making restriction endonucleases with reduced star activity by one or more targeted mutations to a catalytic site within the restriction endonuclease. Examples of modifications to restriction endonucleases with significant sequence identity with KpnI are provided and reduced star activity demonstrated.... Agent: Harriet M. Strimpel, D. Phil.

20080227135 - Autoimmune conditions and nadph oxidase defects: The invention relates to methods and materials involved in diagnosing and treating autoimmune conditions. In particular, the invention relates to methods and materials involved in diagnosing arthritis conditions that are accompanied by an NADPH oxidase deficiency, methods and materials involved in treating, preventing, or delaying the onset of arthritis conditions... Agent: Fish & Richardson P.C.

20080227136 - Cell culture improvements: The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20080227137 - Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells: A method of differentiating embryonic stem cells into ventral spinal progenitor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1−/Pax6+ in the presence of retinoic acid, wherein the cells... Agent: Quarles & Brady LLP

20080227138 - Methods to increase or decrease bone density: The SOST gene gives rise to sclerostin, a protein that leads to apoptosis of bone progenitor cells. The invention provides antagonists to the sclerostin protein, and methods for identifying new sclerostin antagonists. The invention also provides molecules that can depress expression of the SOST gene, as well as methods for... Agent: Marshall, Gerstein & Borun LLP

20080227139 - System, method and applications involving identification of biological circuits such as neurological characteristics: Various aspects are directed to systems and methods for assessing neural activity of a neural region having multiple subfields. In certain embodiments, a method includes evoking a cellular electrical response in at least one subfield due to neural activity in the neural region, capturing image data of the electrical response... Agent: Crawford Maunu PLLC

20080227140 - Trp/his exchange and kynurenine induced trp transport: The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present... Agent: Morgan Lewis & Bockius LLP

20080227141 - Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and... Agent: Fitzpatrick Cella Harper & Scinto

20080227142 - Invasive chemometry: The invention relates to methods and devices for assessing one or more components of a selected tissue in an animal. The present invention permits non-invasive assessment of tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of... Agent: Morgan, Lewis & Bockius LLP

20080227143 - Stabilized hematoxylin: A stabilized hematoxylin composition is disclosed that includes one or both of a host compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process without undue degradation prior to use of the composition to stain a biological sample. Methods of using and... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20080227144 - Tissue sample support and orientation device: Disclosed is a tissue sample support and orientation device comprising: (i) a base member formed of one or more materials which can be sectioned in a microtome and which is resistant to histological stains and to degradation from chemicals used to fix and process tissue; and (ii) a plurality of... Agent: Duane Morris LLP

20080227145 - Filamentous fungal mutants with improved homologous recombination efficiency: The present invention relates to a method for increasing the efficiency of targeted integration of a polynucleotide to a pre-determined site into the genome of a filamentous fungal cell with a preference for NHR, wherein said polynucleotide has a region of homology with said pre-determined site, comprising steering an integration... Agent: Nixon & Vanderhye, PC

20080227148 - Aspergillus promotors for expressing a gene in a fungal cell: The present invention relates to isolated promoter DNA sequences, to DNA constructs, vectors, and host cells comprising these promoters in operative association with coding sequences. The present invention also relates to methods for expressing a gene and/or producing a biological compound using the new promoters isolated. The present invention also... Agent: Nixon & Vanderhye, PC

20080227147 - Fungal cell wall degrading enzyme: A novel fungal enzyme having lysozyme activity has been isolated. The invention further relates to a fungal polypeptide having lysozyme activity and belonging to the GH25 family, wherein the enzyme is selected from the group consisting of (a) a polypeptide comprising an amino acid sequence, which has at least 80%... Agent: Novozymes North America, Inc.

20080227146 - Immortalized avian cell lines for virus production: The present invention relates to immortalized avian cell lines suitable for production of biologicals or viruses for vaccination. In particular, the cell lines are derived from primary cells which are transformed with at least two viral or cellular genes, one of which causes cell cycle progression whereas the other interferes... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20080227152 - In vivo incorporation of unnatural amino acids: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.... Agent: Quine Intellectual Property Law Group, P.C.

20080227149 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department

20080227151 - Method for simultaneous production of multiple proteins; vectors and cells for use therein: Described is the production of proteins in a host cell. Even more specifically, described are methods for improving expression of two or more proteins in a cells or host cell. The methods are suited for production of, for example, recombinant antibodies that can be used in pharmaceutical preparations or as... Agent: Trask Britt

20080227156 - Nucleic acids encoding neutralizing gdf8 epitope-based peptides and fusion proteins: The invention provides new, specific antigenic peptides from the protein GDF8. The invention also provides fusion proteins comprising the new peptides, immunogens and vaccines based on the new peptides and/or fusion proteins, antibodies that specifically bind to the new peptides of GDF8, and methods of treating animals in order to... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20080227150 - Overexpression of phytase genes in yeast systems: The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a heterologous phytase and the vectors used to produce the phytase are also... Agent: Nixon Peabody LLP - Patent Group

20080227155 - Pegylated soluble gp130-dimers useful as a medicament: A polypeptide-dimer comprising two soluble gp130 molecules is described, wherein at least one of said soluble gp130 molecules is covalently linked to polyethylene glycol. Furthermore, a pharmaceutical composition containing said dimer and various medical uses are described.... Agent: Wilson Sonsini Goodrich & Rosati

20080227154 - Protein expression: Disclosed is chimeric polynucleotides adopted for providing high-yield expression and secretion of recombinant polypeptides. The chimeric polynucleotide of the invention includes a functional secretion signal peptide derived from S. pombe carboxypeptidase Y (CPY). The invention also discloses methods for use of this cpy leader sequence.... Agent: Birch Stewart Kolasch & Birch

20080227153 - Site specific incorporation of keto amino acids into proteins: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids... Agent: Quine Intellectual Property Law Group, P.C.

20080227157 - Nucleic acids encoding fusion proteins based on ribosome-inactivating proteins of the mistletoe viscum album: The invention relates to nucleic acid molecules which encode fusion proteins which contain as components at least one effector module, a processing module and a targeting module. The nucleic acid molecules according to the invention preferably also encode a modulator module and/or an affinity module. The invention furthermore relates to... Agent: Panitch Schwarze Belisario & Nadel LLP

20080227158 - Novel polypeptide, novel dna and novel antibody: The present invention relates to a polypeptide having an activity of suppressing aging; DNA encoding the polypeptide; a method for improving livestock, using the DNA; a recombinant DNA prepared by inserting the DNA into a vector; a transformant harboring the recombinant; a method for preparing the polypeptide of the present... Agent: Fitzpatrick Cella Harper & Scinto

20080227159 - Compositions and methods using split polymerases: The invention relates to compositions and methods utilizing split polymerase enzymes composed of at least two discrete polypeptides that stably associate to form a single polymerase. The invention further relates to nucleic acid constructs for expressing the split polymerases of the invention, and methods for using the split polymerases of... Agent: Latimer, Mayberry & MatthewsIPLaw, LLP Suite 106

20080227160 - Circular dna vectors for synthesis of rna and dna: The present invention provides methods for synthesis and therapeutic use of DNA and RNA oligonucleotides and analogs. RNA oligonucleotides are synthesized using a small, circular DNA template which lacks an RNA polymerase promoter sequence. The RNA synthesis is performed by combining a circular single-stranded oligonucleotide template with an effective RNA... Agent: Mueting, Raasch & Gebhardt, P.A.

20080227161 - Methods for producing a hydrolysate and ethanol from lignocellulosic materials: A method for producing a hydrolysate from lignocellulosic materials generally includes fiberizing the lignocellulosic materials, separating the lignocellulosic materials into at least a first portion and a second portion, wherein at least the first portion includes lignin, treating the first portion to deactivate at least a portion of the lignin... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

20080227162 - Biomass pretreatment: A method for lignocellulose conversion to sugar with improvements in yield and rate of sugar production has been developed by using ionic liquid pretreatment. This new pretreatment strategy substantially improves the efficiency (in terms of yield and reaction rates) of saccharification of lignocellulosic biomass. Cellulose and hemicellulose, when hydrolyzed into... Agent: Emch, Schaffer, Schaub & Porcello Co

20080227134 - Glyoxylate assays and their use of inden tifying natural amidated compounds: Methods for detecting and assaying for glyoxylate, include enzyme-based assays and/or assays for hydrogen peroxide following liberation of hydrogen peroxide from glyoxylate, are disclosed. In some embodiments, the invention is directed to methods for assaying for glyoxylate produced by the reaction of peptidylglycine alpha-amidating monooxygenase (PAM). The subject invention also... Agent: Ostrolenk Faber Gerb & Soffen

20080227164 - Process for producing mycophenolic acid using penicillium arenicola bicc 7673: The present invention discloses the manufacture of MPA by fermentation under optimal fermentation parameters using a new strain of Penicillium arenicola.... Agent: Allen, Dyer, Doppelt, Milbrath & Gilchrist P.A.

20080227163 - Production of l-ribose and other rare sugars: The invention provides methods and compositions for the production of L-ribitol and other rare sugars using a mannitol-1-dehydrogenase.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080227165 - Process for producing conjugated fatty acid and food/drink produced by the process: A conjugated fatty acid such as the cis-9, trans-11 isomer of conjugated linoleic acid having high bioactivities is selectively and efficiently produced by conjugating an unsaturated fatty acid having at least two double bonds with the use of viral cells, dead cells or a cell extract of at least one... Agent: Frishauf, Holtz, Goodman & Chick, PC

20080227166 - Fermentation processes: The present invention provides an improved process for producing a fermentation product in a fermentation medium, including ethanol, which process include a fermentation step, comprising subjecting the fermentation medium to at least one surfactant and at least one carbohydrate-source generating enzyme.... Agent: Novozymes North America, Inc.

20080227167 - Process for immobilized nano-sized metal particles: The present invention provides a new process using biological method for the preparation of immobilized nano-particles of metals. Fungi are used to efficiently prepare immobilized nano-particles of various metals ions such as Au, Ag, Pd, Pt, Ni, Rh and Ru from their aqueous solutions.... Agent: Darby & Darby P.C.

20080227168 - Methods and materials for extra and intracellular delivery of carbon nanotubes: The present invention includes compositions and methods to deliver carbon nanostructures that include agents for delivery to cells, wherein the carbon nanostructure and the agent are made soluble by coating the carbon nanostructure with one or more polymers, e.g., low band gap conductive polymers.... Agent: Chalker Flores, LLP

20080227169 - Surface-bound fluorinated esters for amine capture: A method for immobilizing an amino-containing material to a substrate is described. The method involves providing a tethering compound with two reactive groups: a substrate reactive group and a fluoroalkoxycarbonyl group. The method further involves preparing a substrate-attached tethering group by reacting the substrate reactive group of the tethering compound... Agent: 3m Innovative Properties Company

20080227170 - Use of pit emulsions in biocatalytic reactions: Oil-in-water emulsions produced by the phase inversion temperature process, with droplet sizes of 50 to 400 nm, for use as the reaction medium for biocatalytic reactions.... Agent: Cognis Corporation Patent Department

20080227171 - Process for producing lactoperoxidase: A process for producing lactoperoxidase, including: a step (1) for bringing one or more milk materials into contact with a cation exchanger having weakly acidic groups as ion exchange groups to thereby effect adsorption treatment; a step (2) for washing the cation exchanger after the adsorption treatment; a step (3)... Agent: Wood, Herron & Evans, LLP

20080227172 - Sialyltransferase and dna encoding the same: p

20080227173 - Polypeptide: The invention describes a PS4 variant polypeptide derivable from a parent polypeptide having amylase activity selected from the group consisting of: (a) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 161, 178, 179, 223, 229, 272, 303, 307, 309 and... Agent: Frommer Lawrence & Haug

20080227174 - Starch debranching enzymes: The invention relates to a genetically engineered variant of a parent starch debranching enzyme, i.e. a pullulanase or an isamylase, the enzyme variant having an improved thermostability at a pH in the range of 4-6 compared to the parent enzyme and/or an increased activity towards amylopectin and/or glycogen compared to... Agent: Novozymes North America, Inc.

20080227175 - Protease crystals in broth: e

20080227176 - Highly efficient gas permeable devices and methods for culturing cells: This invention relates to methods and devices that improve cell culture efficiency. They include the use of gas permeable culture compartments that reduce the use of space while maintaining uniform culture conditions, and are more suitable for automated liquid handling. They include the integration of gas permeable materials into the... Agent: Patterson, Thuente, Skaar & Christensen, P.A.

20080227178 - Polypeptide factor from a thermophilic eubacterial species and use thereof in the production of functional, heterologous proteins in an expression host: A polypeptide factor derived from the thermophilic eubacterial species Thermus thermophilus has universal protein expression-assisting activity. The polypeptide factor has been named the CzrB protein active in fill length or truncated form has the potential to act as a universal protein expression-assisting molecule which can increase the yields of all... Agent: Birch Stewart Kolasch & Birch

20080227177 - Process for culturing bacteria of the family streptococcaceae: This invention relates to an improved process for culturing bacteria of the family Streptococcaceae (such as of the genus lactococcus), a medium for culturing the bacteria, and the obtained bacteria cells.... Agent: Foley And Lardner LLP Suite 500

20080227179 - New bioremediation enhancing agents and methods of use: A new and improved method for treating contaminated water or other contaminated media has been developed. Bioremediation enhancing agents (BEAs) such as yeast metabolites (YM) and other yeast derived products are used to facilitate microbial treatment of the contaminated material. Polysaccharides are also an effective BEA when used alone or... Agent: Lathrop & Gage Lc

20080227180 - Organic waste management system: A method of managing organic waste and an organic waste management system. The method includes the steps of receiving organic waste liquids and solids in a collection vessel, such as a grease trap. The dissolved oxygen is monitored, the pH level is monitored, the flow is monitored, and the temperature... Agent: Head, Johnson & Kachigian

20080227181 - System and process for treating waste gas employing bio-treatment technology: A waste gas treatment process using biological treatment technology including filtering waste gas to be treated, and introducing the filtered waste gas into a biological treatment system periodically and switchably from two ends of the system.... Agent: Senniger Powers LLP

20080227182 - Systems and methods for enzymatic hydrolysis of lignocellulosic materials: Systems and methods for enzymatic hydrolysis of lignocellulosic materials are provided. A system for enzymatic hydrolysis of lignocellulosic materials generally includes a reactor vessel configured to contain a mixture of lignocellulosic stock and enzymes. The reactor vessel includes a first agitator for mixing in the reactor vessel. The system further... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

20080227183 - Apparatus for supporting diagnosis of cancer: A cancer diagnosis supporting apparatus is provided with a memory for storing a predetermined reference value, a diagnosis support information preparer for preparing the diagnosis support information of cancer by comparing a measurement value obtained from a malignant tumor collected from a cancer patient and the reference value, and a... Agent: Brinks Hofer Gilson & Lione

20080227184 - Method, apparatus and system for quantifying the content of genetically modified material in a sample: A method including providing an initial test sample including a primary material and a relatively smaller amount of at least one adventitious material; combining the initial test sample with a standard addition of at least one adventitious material to form a final test sample, wherein the standard addition has a... Agent: Cargill, Incorporated

20080227186 - Active, micro-well thermal control subsystem: Devices and systems for active thermal control of sample holding devices for bDNA testing, polymerase chain reaction testing, chemiluminescent immuno-assay testing, and so forth. The thermal control subsystem includes a fluidic circuit, first and second heater assemblies, a centrifugal pump, and a heat exchange device. The first and second heater... Agent: Siemens Corporation Intellectual Property Department

20080227185 - Diagnostic system for carrying out a nucleic acid sequence amplification and detection process: An integrated lab-on-a-chip diagnostic system for carrying out a sample preparation process on a fluid sample containing cells and/or particles, the system comprising: (a) an inlet for a fluid sample; (b) a lysis unit for lysis of cells and/or particles contained in the fluid sample; (c) a nucleic acid extraction... Agent: Senniger Powers LLP

20080227188 - Biosensor with optically matched substrate: The matching of refractive index of a nanoporous membrane with an analyte solution used with the membrane for use in a sensor is described. Scattering of the excitation and/or emitted light is reduced by matching the refractive indices. This improves efficiency when the porous translucent membrane is used in flow-through... Agent: Philips Intellectual Property & Standards

20080227187 - Cellular physiology workstations for automated data acquisition and perfusion control: Cellular physiology workstations for automated data acquisition and perfusion control are described. The cellular physiology workstation may be used for physiological and electrophysiological experiments. Methods for employing such cellular physiology workstations in physiological and electrophysiological experiments are also disclosed. The cellular physiology workstations comprise one or more recording chambers each... Agent: Edwards Angell Palmer & Dodge LLP

20080227189 - Device for pressurized perfusion especially for culturing and/or treating cells: The invention relates to a device for pumping a fluid into a bioreactor. Polsatile pumping is made possible by valve arrangement so that growth of the cells in the bioreactor is increased. Pumping function can be achieved though several mechanisms. A piston can be displaced in a cylinder, especially by... Agent: Lerner Greenberg Stemer LLP

20080227190 - Cell expansion apparatus with plate bioreactor: A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being adjacent a plate and separated from said supply area by a membrane. The bioreactor comprises a plurality of plates. The plates have a... Agent: Gambro Bct, IncIPDepartment

20080227191 - Cell culture vessel and cell culture apparatus: A vessel and an apparatus for culturing cells are provided in which a temperature difference is effected so that any position in the vessel can be brought into a temperature at which cells can be attached and a temperature at which cells cannot be attached, thereby freely selecting and recovering... Agent: Fitzpatrick Cella Harper & Scinto

20080227192 - Nematode atp synthase subunit e-like sequences: Nucleic acid molecules from nematodes encoding ATP synthase subunit E polypeptides are described. ATP synthase subunit E-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of ATP synthase subunit E-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators,... Agent: Fish & Richardson PC

20080227193 - Nematode fatty acid desaturase-like sequences: Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators of fatty acid... Agent: Fish & Richardson PC

20080227194 - Canine pancreatic lipase: Isolated nucleic acid molecules having a nucleotide sequence encoding canine pancreatic lipase polypeptides, allelic variants and fragments thereof. Vectors and host cells containing the polynucleotide sequences and methods for expressing the polypeptides. Monoclonal antibodies that specifically binds to the canine pancreatic lipase polypeptides. Cell lines secreting the monoclonal antibodies. Methods... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080227195 - Expanding the eukaryotic genetic code: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic... Agent: Quine Intellectual Property Law Group, P.C.

20080227196 - Antibody composition-producing cell: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for... Agent: Nixon & Vanderhye P.C.

20080227197 - Allogeneic stem cell bank: This invention provides methods for supplying a therapy for individuals exposed to radiation following a nuclear event, through the prospective establishment of an undesignated allogeneic stem cell bank with prospective HLA typing of healthy potential recipients.... Agent: Townsend And Townsend And Crew, LLP

20080227198 - Immunoregulatory antibodies and uses thereof: A combination antibody therapy for treating B cell malignancies using an immunoregulatory antibody, especially an anti-B7, anti-CD23, or anti-CD40L antibody and a B cell depleting antibody, especially anti-CD19, anti-CD20, anti-CD22 or anti-CD37 antibody is provided. Preferably, the combination therapy will comprise anti-B7 and anti-CD20 antibody administration.... Agent: Pillsbury Winthrop Shaw Pittman LLP

20080227201 - In vitro model for neuronal death: This invention demonstrates the formation of a novel polarized membrane lipid raft signaling module in neurons, in response to several diverse neurotoxic stimuli. This polarization occurs well before neurons commit to die, and is an early mechanism in death signaling. The formation of this signaling module is dependent on cholesterol... Agent: Chester G. Moore Baker, Donelson, Bearman, Caldwell & Berkowitz, PC

20080227199 - Method for simultaneous production of multiple proteins; vectors and cells for use therein: Described is the production of proteins in a host cell. More specifically, described are methods for improving expression of two or more proteins in a cell or host cell. The methods are suited for production of, for example, recombinant antibodies that can be used in pharmaceutical preparations or as diagnostic... Agent: Trask Britt

20080227200 - Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and dna coding for the same: A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation... Agent: Robins & Pasternak

20080227202 - Method of promoting differentiation of one or more human stem cells into human coronary endothelial cells on a synthetic tubular structure: A method of promoting differentiation of one or more human stem cells into human coronary endothelial cells on at least one surface of a synthetic tubular structure to be used to make a human hybrid hemodialysis access graft is provided. The method includes arranging a plurality of human stem cells... Agent: Rene A. Vazquez

20080227203 - Cell culture support and manufacture thereof: An object of the present invention is to provide a cell culture support making the detachment of a cell sheet easy as well as enabling the formation of a uniform cell sheet. The present invention relates to a method for manufacturing a cell culture support having a temperature responsive polymer... Agent: Sughrue Mion, PLLC

20080227204 - Process for producing cytotoxic lymphocyte: The present invention relates to a method for preparing a cytotoxic lymphocyte characterized in that the method comprises the step of carrying out at least one of induction, maintenance and expansion of a cytotoxic lymphocyte in the presence of fibronectin, a fragment thereof or a mixture thereof.... Agent: Birch Stewart Kolasch & Birch

20080227205 - Incorporation on non-naturally encoded amino acids into proteins: The invention provides methods and compositions for in vivo incorporation of non-naturally encoded amino acids into polypeptides by Pseudomonas species and strains derived therefrom. Also provided are compositions including proteins with non-naturally encoded amino acids made by Pseudomonas species and strains derived therefrom.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080220406 - Physiologically acceptable aqueous solutions and methods for their use: Artificial plasma-like solutions and methods for their use are provided. The subject solutions include: electrolytes and an oncotic agent. The subject solutions find use in a variety of applications, particularly in those applications where at least a portion of a host's blood volume is replaced with a blood substitute.... Agent: Bozicevic, Field & Francis LLP

20080220407 - Fluorescent water-soluble conjugated polyene compounds that exhibit aggregation induced emission and methods of making and using same: The presently described subject matter is directed to water-soluble conjugated polyene compounds that exhibit aggregation induced emission, as well as to water dispersible, fluorescent, polymeric microparticles and/or nanoparticles comprising the water-soluble conjugated polyene compounds. Also provided are methods of making and using the compounds and particles. The described conjugated polyene... Agent: Nath & Associates

20080220409 - Antigen of dengue virus type 1: Antigens and B-cell epitopes derived from dengue virus type 1 are provided. The antigens are specifically immunoreactive with sera from individuals infected with dengue virus type 1 but not reactive with sera from healthy individuals and individuals infected with dengue virus type 2. The antigens and epitopes are useful for... Agent: Wpat, Pc Intellectual Property Attorneys

20080220412 - Method and means for determining the replication rate of a viral population: The present invention relates to methods and means for determining the replication rate of a viral population. More specifically, the invention provides methods and means for determining the replication rate of a viral population by performing a linear regression on signal data generated by cells infected with dilutions of the... Agent: Philip S. Johnson Johnson & Johnson

20080220410 - Method for replicating the hepatitis c virus: The invention concerns the use of cells capable of carrying out a process of prenylation of proteins coded by the hepatitis C virus (HCV) genome, such as prenylation of the NS5A protein, for replicating and, if required, the production of HCV or derivative viable mutants, in a suitable culture medium.... Agent: Young & Thompson

20080220411 - Non-linear rotation rates of remotely driven particles and uses thereof: The present invention relates to biological sensors. In particular, the present invention relates to the use of remotely driven nonlinear rotation of particles (e.g., magnetic particles) for detection of cells such as microorganisms (e.g., bacteria and viruses). The present invention further relates to the use of remotely driven nonlinear rotation... Agent: Casimir Jones, S.c.

20080220408 - Protein scaffolds and viral particles for detecting analytes: The present invention relates to compositions and methods for detecting analytes using detectably labeled fluorescent protein scaffolds. In certain embodiments of the invention, the scaffolds are viral particles in which the capsid viral structure provides a scaffold to attach detectably labeled fluorescent dyes and capture moieties that can be utilized... Agent: Naval Research Laboratory Associate Counsel (patents)

20080220431 - Cell fusion method: The invention provides methods for fusing a first cell with a second cell to form a hybrid cell. The methods involve incubating a first parental cell producing a first partner of a fusogenic binding partner pair on its surface with a second parental cell producing a second partner of the... Agent: Bozicevic, Field & Francis LLP

20080220413 - Clean-up beads: The present invention provides a material for separating an analyte from an undesired constituent, which material comprises a solid phase and a coating, wherein the solid phase is capable of binding the undesired constituent, and wherein the coating covers the exposed surface of the solid phase to an extent that... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080220428 - Compositions and methods for detecting methicillin-resistant s. aureus: The present invention relates to methods of detecting the presence or absence of methicillin-resistant S. aureus (MRSA) in a sample, the method comprising performing an amplifying step, a hybridizing step and a detecting step. Furthermore, the present invention relates to primers, probes and kits for the detection of MRSA.... Agent: Fish & Richardson P.c.

20080220433 - Detecting methylated mammalian nucleic acid in stool: This document includes methods and materials for enriching and detecting cancer markers. For example, this document includes methods and materials for enriching methylated mammalian nucleic acid from stool samples.... Agent: Fish & Richardson P.c.

20080220415 - Detection method of dna amplification using probe labeled with intercalating dye: The present invention relates to a detection method of nucleic acid amplification using probe labeled with intercalating dye. More particularly, the present invention is directed to a real-time detection method of nucleic acid amplification, comprising the steps of i) producing an aqueous buffer which contains a nucleic acid, a pair... Agent: Nath & Associates

20080220434 - Detection of molecule proximity: The present invention provides methods, compositions and kits for identifying molecules such as proteins or nucleic acids that are found in proximity to each other in vitro or in vivo. For example, the present invention provides for the modification of one or more molecules that are complexed with, or in... Agent: Casimir Jones, S.c.

20080220421 - Isothermal screening for nucleic acids associated with diseases and conditions of the gi tract: The presently described technology relates generally to the art of molecular diagnostics and more particularly to point-of-care diagnostic methods and materials. The diagnostic methods and materials of the presently described technology are suitable for a variety of uses including but not limited to the bedside or field diagnosis of infectious... Agent: Mcandrews Held & Malloy, Ltd

20080220435 - Method for detecting target substance utilizing probe desorption: It is an object of the present invention to provide a method for detecting a target substance in a specimen with the use of fine particles, whereby the target substance can be readily detected with the exclusive use of a single type of probe and the detection limit is improved.... Agent: Sughrue Mion, Pllc

20080220424 - Method for predicting responsiveness to drugs: The present invention provides a novel method to determine the likelihood of effectiveness of a treatment in an individual affected with or at risk for developing cancer. The method involves detecting the presence or absence of Met amplification in an individual. The presence of Met amplification indicates that a Met... Agent: David S. Resnick

20080220420 - Method of detecting gene polymorphism, method of diagnosing, apparatus therefor, and test reagent kit: The object of the invention is to carry out typing for multiple SNP sites automatically from the stage of sample preparation. A mixture of sample (2) and PCR reaction solution (4) is subjected to PCR reaction according to a given temperature cycle. After the completion of PCR reaction, invader reagent... Agent: Kratz, Quintos & Hanson, LLP

20080220419 - Method of isolating p450 gene: The present invention further provides a fused cytochrome P450 monooxygenase containing a peptide which is linked to the C-terminus of a P450 protein with a linker portion disposed therebetween and which has the same function as that of a reductase domain contained in a cytochrome P450 monooxygenase originating from Rhodococcus... Agent: Birch Stewart Kolasch & Birch

20080220414 - Method, chip, device and integrated system for detection biological particles: The present invention relates to a method, a chip, a device, and a system for detection of biological particles. The method of the invention typically comprises collecting the biological particles from a gaseous sample, contacting the biological particles with a first liquid reagent, extracting biological material from the collected biological... Agent: Knobbe Martens Olson & Bear LLP

20080220425 - Methods and compositions for detecting target sequences: The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for amplifying a synthetic DNA from a target nucleic acid, forming a nucleic acid cleavage structure on the synthetic DNA, and... Agent: Casimir Jones, S.c.

20080220436 - Methods and compositions for rapid light-activated isolation and detection of analytes: The present invention relates to novel methods for isolating a target molecule from a sample suspected of containing the target molecule. The methods of the present invention utilize solid substrates as a means for capturing, separating, and releasing target molecules, such as chemical or biological compounds. The present invention is... Agent: Brinks Hofer Gilson & Lione

20080220430 - Methods for assessing risk for cardiac dysrythmia in a human subject: The present invention relates to methods for assessing the risk of a patient for developing a potentially fatal cardiac dysrhythmia and for diagnosing Andersen's Syndrome. A tissue sample from a patient is obtained and the DNA or proteins of the sample isolated. From the DNA and protein isolates the sequence... Agent: The Mccallum Law Firm, P. C.

20080220439 - Microorganism detecting kit, microorganism counting apparatus, and microorganism counting process: A microorganism detecting kit according to the present invention includes a self-adhesive layer 102 containing the following compounds incorporated therein: 4′,6-diamidino-2-phenylindole dihydrochloride 2 for staining living and dead cells, propidium iodide 3 for staining dead cells, 6-carboxyfluorescein diacetate 4 for staining living cells and 4-methylumbelliferyl-β-D-galactoside 5 reacting with a substance... Agent: Kratz, Quintos & Hanson, LLP

20080220426 - Mn gene and protein: Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked... Agent: Leona L. Lauder

20080220417 - Novel alanine transaminase enzymes and methods of use: Novel alanine transaminase (ALT) polypeptides and the use thereof as a diagnostic marker to predict and monitor tissue damage and/or tissue malfunction. The ALT polypeptides are murine and/or rattus ALT polypeptides and said ALT polypeptides are used to detect, predict and/or determine hepatic processes of an animal, particularly mice and/or... Agent: Pauley Petersen & Erickson

20080220423 - Oligonucleotide probes useful for detection and analysis of microrna precursors: The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNA precursors and their targets. The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single transcripts, mutations, deletions, or duplications of particular... Agent: Clark & Elbing LLP

20080220432 - Optimized host cells for protein production: The present invention relates to methods for isolating cells that express increased levels of an RNA or protein of interest, wherein the cells exhibit altered growth profiles, such as cells with increased or decreased rates of proliferation, increased or decreased rates of apoptosis, or cells with a biphasic growth profile.... Agent: Ropes & Gray LLP

20080220422 - Rare cell analysis using sample splitting and dna tags: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves labeling regions of genomic DNA in each cell in said mixed sample with... Agent: Wilson Sonsini Goodrich & Rosati

20080220429 - Single nucleotide polymorphisms and the identification of lactose intolerance: The present invention relates generally to methods, kits, genotyping and/or nucleic acid molecules associated with the identification of a predisposition for lactase persistence, lactase non-persistence, lactose tolerance and/or lactose intolerance. The methods of the present invention comprise in general determining the presence or absence of at least one variant allele... Agent: Kramer & Amado, P.c.

20080220437 - Substrate material for handling and analysing samples: The invention relates to a substrate material for analyzing one or more fluid samples for the presence, amount or identity of one or more analytes in the samples, whereby the substrate material is adapted in that way that a flow of the sample or parts thereof in and/or with the... Agent: Philips Intellectual Property & Standards

20080220438 - Telomerase promoter sequences for screening telomerase modulators: Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is turned off in mature differentiated cells, but is turned back on again in hyperplastic diseases, including many cancers. This disclosure provides regulatory elements that promote... Agent: Geron Corporation Attn. David J. Earp

20080220427 - Test for determining blood type in the cat: The present invention provides compositions and methods for detecting mutations associated with blood type determination in the cat.... Agent: Townsend And Townsend And Crew, LLP

20080220441 - Advanced drug development and manufacturing: X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and... Agent: Los Alamos National Security, Llc

20080220442 - Difference detection methods using isoelectric focusing chips: The present invention provides an isoelectric focusing difference detection method, as well as an isoelectric focusing chip and device. The method entails labeling proteins in the first sample with a first label, and labeling proteins in the second sample with a second, different label, wherein each label has ionic and... Agent: Beyer Weaver LLP

20080220443 - Methods of screening for modulators of h2-calponin activity: The invention provides methods for identifying modulators of mammalian, e.g., human, h2-calponin, the calponin isoform of relatively neutral pI. H2-calponin exerts an effect on the migration and proliferation of a variety of muscle (smooth muscle) and non-muscle cells and is an actin filament-associated regulatory protein influencing the structure of the... Agent: Marshall, Gerstein & Borun LLP

20080220440 - Waveguide sensors optimized for discrimination against non-specific binding: A system for interferometrically detecting the present of bound material using a wave propagating waveguide and the influence on propagation time of bound material in the proximity of the waveguide. The waveguide layer thickness and the radiation wavelength λ are selected so that the effects on phase difference between the... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20080220444 - Bone marrow proliferation assay: Disclosed herein are assay methods for assessing the myelotoxicity of a pharmacologic agent or a putative pharmacologic agent. Also, disclosed are kits and mixtures of cytokines and growth factors useful in the assay methods disclosed herein.... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20080220446 - Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein: The invention relates to the field of aqueous solutions comprising a protein. More specifically, the invention relates to the detection and/or removal of conformationally altered proteins and/or peptides comprising a cross-β structure from an aqueous solution comprising a protein. The invention provides methods for detecting and/or removing proteins and/or peptides... Agent: Trask Britt

20080220445 - Method of screening transmembrane enzyme inhibitory substance: The present invention provides a screening method for a compound inhibiting a transmembrane enzyme activity by binding to a transmembrane region of the enzyme, characterized by using (a) a protein having a part or all of an amino acid sequence of the enzyme, comprising a region comprising an active center... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080220452 - Kit for determining polysaccharide-binding ability of mononuclear cells present in peripheral blood: A kit for the determination of the ability of a peripheral blood mononuclear cell to bind to a polysaccharide herein provided comprises a detection reagent comprising a fluorescence-labeled immunostimulant polysaccharide; and a reference reagent comprising a fluorescence-labeled material of a polysaccharide different from that used in the fluorescence-labeled immunostimulant polysaccharide,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080220450 - Population based prediction methods for immune response determinations and methods for verifying immunological response data: The present invention provides means to assess immune response profiles of populations. In particular, the present invention provides means to qualitatively assess the immune response of human populations, wherein the immune response directed against any protein of interest is analyzed. The present invention further provides means to rank proteins based... Agent: Genencor International, Inc. Attention: Legal Department

20080220451 - T1r2 binding assays: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department

20080220453 - Identification and isolation of squamous carcinoma stem cells: Squamous carcinoma stem cells (SCSC) are identified. The cells can be prospectively isolated or identified from primary tumor samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and to form unique histological microdomains useful in cancer... Agent: Bozicevic, Field & Francis LLP

20080220454 - Identification of genotype- selective anti-tumor agents: The present invention relate to methods of identifying a genotype-selective agent. In certain embodiments, the invention relates to agents that are selectively toxic to engineered human tumorigenic cells.... Agent: Ropes & Gray LLP

20080220455 - P53-dependent apoptosis-inducing protein and method of screening for apoptosis regulator: p53-dependent Damage-Inducible Nuclear Protein 1 (p53DINP1 protein) is a p53-induced nuclear protein that induces p53-dependent apoptosis by regulating p53 function through Ser 46 phosphorylation. A DNA encoding p53DINP1 can be applied as anticancer agents for destroying neoplasms such as tumors, and as therapeutic or preventive agents for diseases associated with... Agent: Townsend And Townsend And Crew, LLP

20080220458 - Antibodies specific to antigens of bartonella henselae and use of these antigens in immunoassays: Disclosed are antibodies that bind to the antigenic proteins GroES, RpIL, GroEL, SodB, UbiG, the ABC transporter, and an expressed antigenic protein of unknown function (the “BepA” protein) of Bartonella henselae, and use of these antigenic proteins in immunoassays in order to determine whether a sample from a subject contains... Agent: Dunlap Codding, P.c.

20080220456 - Luminescence resonance energy transfer (lret) assays for clostridial toxin activity: Clostridial toxin substrates comprising a lanthanide donor complex, an acceptor, and a Clostridial toxin recognition sequence including a cleavage site; methods for determining the activity of a Clostridial toxin from a test sample using such Clostridial toxin substrates; cell compositions comprising such Clostridial toxin substrates and a Clostridial toxin receptor;... Agent: Dean G. Stathakis (t2-7h) Allergan, Inc.

20080220457 - Serum bactericidal assay for n. meningitidis specific antisera: The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular N. meningitidis. The SBA assay is the most important method for measuring functional activity of serum antibodies against meningococcus. In order to determine whether a subject or a population is seropositive... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B482

20080220447 - Method for the detection of disease-related prion: Methods for the detection of the disease associated conformation of the prion protein as an indication of transmissible spongiform encephalopathies (TSEs), including preclinical detection of infected live animals and humans, and post-mortem detection methods are disclosed. In one aspect, the tissue or body fluid sample of a test subject is... Agent: Rankin, Hill & Clark LLP

20080220448 - Antigenic protein conjugates and process for preparing same: An improved process for the preparation of antigenic protein conjugates is provided. The conjugates preferably are formed through reaction with one or more free sulfhydryl groups in the antigenic protein. The process of the present invention preferably employs a trialkylphosphine as the reducing agent and allows for reduction of disulfide... Agent: Paul D. Yasger Abbott Laboratories

20080220449 - Biomarkers and assays for alzheimer's disease: Methods, compositions and systems are provided for diagnosing, stratifying, or monitoring the progression or regression of Alzheimer's disease (AD), the methods, compositions and systems comprise detecting in a sample a level of at least one AD biomarker, the AD biomarker comprising at least phosphorylated tau pT217, soluble tau oligomer, tau-amyloid-beta... Agent: Kalow & Springut LLP

20080220459 - Diagnosis of collagen ix destruction: A method for detecting or monitoring the presence of protein fragments, cleaved at novel cleaving sites near the N-terminal part of the collagen IX alpha 1 chain, close to the C-terminal part of the NC4 domain, and at the COL3 domain close to the NC3 domain. Neoepitope antibodies against the... Agent: Lynn E Barber

20080220461 - Methods for using a diagnostic test strip for collecting and detecting an analyte in a fluid sample: A test strip for use of the determination of an analyte in a fluid sample according to one embodiment of the present invention is disclosed. The test strip comprises a base having a top and a bottom, a collection chamber that extends between the top and the bottom of the... Agent: John C. Gatz Nixon Peabody LLP

20080220460 - Modified flavin adenine dinucleotide dependent glucose dehydrogenase: Method for Achieving the Object: A modified flavin adenine dinucleotide dependent glucose dehydrogenase (FADGDH) with more improved heat stability than FADGDH derived from wild-type FADGDH, the modified FADGDH being derived from preferably a eukaryote, more preferably a filamentous fungus, and furthermore preferably an Aspergillus fungus, and, for example, those having... Agent: Leydig Voit & Mayer, Ltd

20080220462 - Kit for detection of hemolytic streptococcus: A reagent is provided for the detection of an exotoxin protein produced by a beta-hemolytic streptococcus bacteria suspected of being present in a host biological fluid collected from a subject. An enzyme inhibitor is present to inhibit rogue protein modification of the substrate to prevent a false positive result of... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20080220464 - Blood test instrument using a disposable cartridge: A blood test instrument using a disposable cartridge and a method of measuring a blood sample using the instrument are disclosed. The instrument includes a cell counting station for counting blood cells by electrical resistance measurement, a pressure actuating component adapted to apply a pressure alternately on two flexible receptacles... Agent: Birch Stewart Kolasch & Birch

20080220463 - Method of cell chromatography: A method is provided of conducting cell chromatography with a group of cells. Each cell has a fluorescence intensity. The method includes the step of depositing the group of cells into a first chamber for a first predetermined time period such that a first portion of cells of the group... Agent: Boyle Fredrickson S.c.

20080220465 - Antibiotic sensitivity testing method: The method includes several steps including obtaining a bacterial sample; identifying the type of bacteria in the bacterial sample; selecting a set of antibiotics based on the identity of the bacteria in the bacterial sample; obtaining a control sample from the bacterial sample; placing the bacterial sample in solutions containing... Agent: The Webb Law Firm, P.c.

20080220467 - Filter snapper: A device for applying an axial compressive force to a fluid contamination detection system comprising a cup joined by a frangible connection to a filter ring, the force being sufficient to break the frangible connection and collapse a portion of the ring into the cup without damaging the ring. The... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080220466 - In vitro techniques for use with stem cells: A method is provided for use with extracted blood, including (a) applying blood to a first gradient suitable for selecting first-pass cells having a density less than 1.077 g/ml; (b) applying the first-pass cells to a second gradient suitable for selecting second-pass cells having a density between 1.055 and 1.074... Agent: Cooper & Dunham, LLP

20080220468 - Histological tissue specimen treatment: A tissue processor for processing tissue samples for histological analysis. The processor comprises two retorts, wax baths, reagent containers, a pump and valve. The vale distributes the reagent from one container to either retort. Separate reagent lines connect the wax baths to the retorts. A method of infiltrating a sample... Agent: Shook, Hardy & Bacon LLP Intellectual Property Department

20080220469 - Method and devices for the cross-referencing of identification of tissue slice supports for microtomised analytical samples: The invention relates to a method and device for the cross-referencing of identification (1) of tissue slice supports (2), for microtomised analytical samples still to be mounted thereon, with identification information (3) of a tissue sample holder (4) of a tissue sample (5) which is not yet microtomised. The conventional... Agent: Kohler Schmid Moebus

20080220470 - Protein hydrolysate rich in tripeptides: The present invention describes a protein hydrolysate which is rich in tripeptides whereby the tripeptides are rich in proline at one end of the peptide.... Agent: Nixon & Vanderhye, Pc

20080220473 - Endo-n-acetyl-beta-d-glucosaminidase enzymes of filamentous fungi: The present invention discloses mannosyl-glycoprotein endo-beta-N-acetylglucosamidase (E.C.3.2.1.96, endo-N-acetyl-beta-D-glucosaminidase acting on the di-N-acetylchitobiosyl part of N-linked glycans) from filamentous fungi such as Trichoderma reesei.... Agent: Clark & Elbing LLP

20080220474 - Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast: The promoter regions associated with the Yarrowia lipolytica glyceraldehyde-3-phosphate dehydrogenase (gpd) and phosphoglycerate mutase (gpm) genes have been found to be particularly effective for the expression of heterologous genes in oleaginous yeast. The promoter regions of the invention have been shown to drive high-level expression of genes involved in the... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080220472 - In vivo incorporation of alkynyl amino acids into proteins in eubacteria: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate alkynyl amino acids such as para-propargyloxyphenylalanine into proteins produced in a eubacteria host such as E. coli. The invention provides novel orthoghonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing... Agent: Quine Intellectual Property Law Group, P.c.

20080220475 - Mtor ligands and polynucleotides encoding mtor ligands: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mTOR activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag... Agent: Intrexon Corporation

20080220477 - Non-natural labeled amino acid and method for producing a conjugate of said amino acid and trna: This invention relates to: a labeled amino acid that can be introduced into a protein with the aid of a protein synthesis system; a functional protein having functions derived from a label compound; a labeled amino acid comprising an aromatic ring bound to an amino acid side chain and a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080220476 - Thermostable alpha-amylases: i

20080220471 - Vectors and methods using same: The present invention is directed to vectors and to methods of using same.... Agent: Genentech, Inc.

20080220478 - Trimerizing polypeptides: The present invention relates to a method of preparing a trimeric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a ZymoZipper (ZZ) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion of... Agent: Zymogenetics, Inc. Intellectual Property Department

20080220480 - Method for producing methanol, dimethyl ether, derived synthetic hydrocarbons and their products from carbon dioxide and water (moisture) of the air as sole source material: A method for producing methanol and dimethyl ether using the air as the sole source of materials is disclosed. The invention relates to a method for producing methanol by removing water from atmospheric air, obtaining hydrogen from the removed water, obtaining carbon dioxide from atmospheric air; and converting the carbon... Agent: Winston & Strawn LLP Patent Department

20080220479 - Polynucleotides encoding il-17 receptor a antigen binding proteins: The present invention relates to IL-17 receptor A (IL-17RA or IL-17R) antigen binding proteins, such as antibodies, and the polynucleotide sequences encoding them, as well as host cells, expression vecotors, and methods of making IL-17 receptor A antigen binding proteins.... Agent: Amgen Inc. Law Department

20080220481 - Sample plate assembly and method of processing biological samples: The invention concerns a v-bottomed sample plate, a frame for sample plates and a kit and method for processing biological samples. The kit comprises a tray assembly and a plurality of sample plates designed to fit into the tray assembly. The tray assembly comprises a frame having a central plate... Agent: Birch Stewart Kolasch & Birch

20080220482 - Production of crystalline short chain amylose: A process for producing a starch comprises treating a feed starch that comprises amylopectin with glucanotransferase to produce a chain-extended starch, and treating the chain-extended starch with a debranching enzyme to produce a starch product that comprises amylose fragments. At least about 38% by weight of the amylose fragments have... Agent: Williams, Morgan & Amerson, P.c.

20080220416 - Compositions for inhibiting cell growth and inducing apoptosis in cancer cells and methods of use thereof: This invention provides compounds, methods and pharmaceutical compositions for inhibiting cancer cell growth and inducing apoptosis in cancer cells, particularly cells resistant to conventional chemotherapeutic drug treatment.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080220418 - Method for providing dna fragments derived from an archived sample: Aspects of the present invention relate to compositions and methods for providing DNA fragments from an archived sample (e.g., paraffin-embedded and/or fixed-tissue biopsies, etc). Particular aspects provide methods whereby high yields of DNA are isolated as well as a substantial portion of the DNA consists of long DNA fragments, and... Agent: Davis Wright Tremaine, LLP/seattle

20080220483 - Compound for derivatizing polypeptides and method for sequencing and quantifying amino acids in polypeptides using the same: The present invention relates to a compound for N-terminal substitution of polypeptides which is used in sequencing and quantifying amino acids and a method for sequencing and quantifying an amino acid sequence using the same. The method for sequencing and quantifying amino acids in accordance with the present invention leads... Agent: Christie, Parker & Hale, LLP

20080220484 - Novel dehydrogenases, the derivatives thereof, and method for the production of optically active alkanols: The present invention relates to proteins having an enzymatic activity of reducing substituted alkanones such as 3-methylamino-1-(2-thienyl)-propan-1-one. The invention furthermore relates to nucleic acids coding for said proteins, nucleic acid constructs, vectors, genetically modified microorganisms and to methods for preparing optically active substituted alkanols, such as, for example, (S)-3-methylamino-1-(2-thienyl)-(S)-propanol.... Agent: Connolly Bove Lodge & Hutz, LLP

20080220485 - Enzymatic conversion of epoxides: The invention relates to a process for converting an epoxide to an alcohol. The process according to the invention is enzymatically catalyzed and highly enantioselective and regiospecific.... Agent: Dechert, LLP

20080220486 - Method for growing photosynthetic organisms: A method of growing photosynthetic organisms comprising providing the organisms with flue gases from a fossil-fuel power plant, the gases being previously treated by desulfurization. The carbon dioxide (CO2) concentration of the flue gases may be increased over the CO2 concentration as released from the power plant. Also disclosed is... Agent: Nath & Associates

20080220487 - Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols: The present invention relates to compositions and methods utilizing thermostable and novel alcohol dehydrogenase enzymes for biosynthesizing chiral specific molecules for use as precursor molecules in synthesizing pharmaceutical compounds. Particularly, in preferred embodiments, the invention relates to directed engineering of an enzymatic catalytic site of an alcohol dehydrogenase enzyme gene... Agent: Peter G. Carroll Medlen & Carroll, LLP

20080220489 - Efficient use of biogas carbon dioxide in liquid fuel synthesis: The invention provides methods for producing methanol, higher alcohols (containing 2 or more carbons), in particular ethanol, or diesel fuel from biological wastes such as manure, sewage, and crop wastes, as well as from other organic materials. In the methods, organic material is first fermented by anaerobic microorganisms to a... Agent: Hugh Mctavish Mctavish Patent Firm

20080220488 - Process for making isooctenes from dry 1-butanol: The present invention relates to a process for making isooctenes using dry 1-butanol derived from fermentation broth. The isooctenes so produced are useful for the production of fuel additives.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080220490 - Method for improving organisms using flux scanning based on enforced objective flux: The present invention relates to a method for improving useful substance-producing organisms using metabolic flux analysis, and more particularly to a method for improving a host organism producing a useful substance, the method comprising: calculating a maximum flux value corresponding to the theoretical maximum yield of the useful substance in... Agent: Intellectual Property / Technology Law

20080220491 - Method and device for electroporation of biological cells: Described are methods for electrical treatment of biological cells, in particular using electrical field pulses, involving the steps: arrangement of the cells (1) on apertures (2) of a solid planar carrier element (3) which divides a measuring chamber (10) into two compartments (11, 12); and temporary formation of an electrical... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20080220492 - Stabilization of biological materials through inactivation of metalloenzymes: Methods are disclosed for the sterilization of functional biological materials, and for their preservation for shelf storage at uncontrolled temperatures. Biological contaminants are significantly reduced in titer or eliminated while maintaining preservation of functional integrity of sterilized and stabilized products. The sterilized and stabilized functional biological material can be stored... Agent: Fulwider Patton LLP

20080220493 - Composite electroporation plate with interchangeable well inserts: Electroporation on a plurality of samples of membranous structures is performed in an electroporation well plate that includes a frame that can hold a plurality of well strips to form a two-dimensional array of wells, and a set of well strips, the set containing strips that differ in the number... Agent: Townsend And Townsend And Crew, LLP

20080220494 - Method of transforming extracellular components of the dermis into a gelatinized substance: The present invention relates to a method to transform all extracellular components of a dermis into a gelatinized substance with long permanence, wherein these extracellular components are obtained from autologous samples of skin of a patient. This method eliminates epidermic cells completely and allows obtaining autologous dermis. The extracellular components... Agent: Defillo & Associates, Inc.

20080220496 - Catalase decomposition of hydrogen peroxide in surfactants: A process comprising the steps of continuously adding a catalase enzyme to a process stream, wherein the process stream comprises an amine oxide surfactant and hydrogen peroxide; and mixing the process stream and catalase enzyme.... Agent: The Procter & Gamble Company Intellectual Property Division - West Bldg.

20080220495 - Delta3, fthma-070, tango85, tango77, spoil, neokine, tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof: The invention provides novel Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 proteins, the invention further provides isolated Delta3, FTHMA-070, Tango85, Tango77, SPOIL, NEOKINE, Tango129 and A259 fusion proteins,... Agent: Millennium Pharmaceuticals, Inc.

20080220497 - Modulation of protein functionalities: New methods for the rational identification of molecules capable of interacting with specific naturally occurring proteins are provided, in order to yield new pharmacologically important compounds and treatment modalities. Broadly, the method comprises the steps of identifying a switch control ligand forming a part of a particular protein of interest,... Agent: Hovey Williams LLP

20080220498 - Variant buttiauxella sp. phytases having altered properties: The present invention relates to variant phytase enzymes having altered properties.... Agent: Lynn Marcus-wyner Genencor International, Inc.

20080220499 - Novel protease for industrial applications: The present invention relates to an extracellular enzyme protease obtained by growing the culture of Pseudomonas aeruginosa MCM B-327 isolated from vermiculture pit soil and deposited in MTCC, IMTECH, Chandigarh with designation MTCC 5270, in production medium of pH 7.0; containing soybean meal and tryptone as raw materials, at 30°... Agent: Luedeka, Neely & Graham, P.c.

20080220500 - Human elongase genes, uses thereof, and compounds for modulating same: The present invention relates to elongase genes, their polypeptides and their control regions, and the use of such genes, polypeptides and control regions in determining compositions for use in the treatment of disease. The identified compositions regulate the expression of the elongase genes or modulate the activity of their protein... Agent: Howrey LLP - Dc

20080220501 - Continuous culture apparatus with mobile vessel, allowing selection of filter cell variants: Method and device that increases the rate of reproduction (through increased speed of reproduction and/or increased reproductive yield) of living cells in suspension or of any culturable organisms through the process of natural selection, said device comprising: a) a flexible, sterile tube (7) containing culture medium, b) a system of... Agent: Young & Thompson

20080220502 - Directed evolution of microorganisms: The present invention provides methods for directing the evolution of microorganisms comprising the use of mutator genes and growth under conditions of selective pressure. The method discloses mutator genes which can be used in the methods of the present invention and provides ATCC deposits which exemplify the evolved microorganisms produced... Agent: Genencor International, Inc. Attention: Legal Department

20080220503 - Screening method for genes of brewing yeast: Provided herein are a method for selecting a gene participating in the desire brewing character and compiling a database of the whole genome sequence of industrial yeast; identifying a gene participating in a brewing characteristic from the database; functional analysis of the gene; and a DNA array of the whole... Agent: Drinker Biddle & Reath (dc)

20080220504 - Bioremediation methods: A method and composition for bioremediation of environmental material. In one embodiment, material to be bioremediated is debris is obtained from a metropolitan street cleaning operation. An environmentally safe all natural non-pathogenic microbial composition is used under conditions sufficient to bioremediate the material.... Agent: Thompson Hine L.l.p. Intellectual Property Group

20080220505 - Recovery and purification of polyhydroxyalkanoates: The present invention relates to a method to recover, purify and isolate polyhydroxyalkanoate (PHA) biopolymers from PHA-containing cell mass, which includes: (a) solubilizing the non-PHA cell mass in an acidic solution, leaving a suspension of partially crystallized PHA granules; (b) adjusting the pH of the suspension to 7-11 and separating... Agent: Duane Morris, LLP Ip Department

20080220507 - Kit for packaging predetermined volume of substance to be preserved by cryogenic vitrification: The invention concerns an assembly for packaging a volume of substance to be preserved by cryogenic vitrification characterized in that it comprises a sheathing (2) including a thin tube (6) having a predetermined internal diameter (Di) and a predetermined length (L); a support (3) comprising a zone for receiving said... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080220506 - Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof: A tubular tissue scaffold is described which comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube where the pitch of the helical pattern changes with the radial position in the tube wall. The... Agent: Marcia T. Greci

20080220508 - Bacteriophages that infect bacillus bacteria (anthrax): The invention provides bacteriophages that infect Bacillus bacteria, including Bacillus anthracis, and compositions containing the bacteriophages. The invention also provides methods for using the bacteriophages of the invention to prevent and treat infection of an organism by Bacillus bacteria. Methods and materials to decontaminate a surface or an organism that... Agent: Intellectual Property Group Fredrikson & Byron, P.a.

20080220510 - Device for diluting a fluid and detecting analytes within a diluted fluid: The present invention provides a device for processing, sampling, and diluting a fluid and for detecting an analyte within the processed, sampled, and diluted fluid. In the device for processing, sampling, and diluting a fluid, an amount of fluid to be processed, sampled, and diluted is accepted by a compressible... Agent: Christensen, O'connor, Johnson, Kindness, Pllc

20080220509 - Nucleic acid amplifier: Disclosed herein is a nucleic acid amplifier for carrying out a nucleic acid amplification reaction, the amplifier including at least: a plurality of wells configured to carry out the nucleic acid amplification reaction; a heating unit provided for every well; optical means capable of irradiating excitation light of a specified... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080220511 - Cell for measuring biological activities and/or physiological parameters of micro-organisms: Device for the measurement of biological activities and/or physiological magnitudes, includes a measuring cell, equipped with a chamber suitable to receive micro-organisms to be analyzed, and one or more probes opening into the chamber. The probes are connected to measuring resources and resources for processing the electrical signals emitted by... Agent: Young & Thompson

20080220512 - Tunable laser-based spectroscopy system for non-invasively measuring body water content: The present disclosure relates to a tunable laser-based spectroscopy system for accurately and non-invasively measuring body water content. The body water content is one of the important health indicators, by which one can quantitatively monitor the hydration level of body and determine if it is necessary to supplement or reduce... Agent: Nellcor Puritan Bennett Llc Attn: Ip Legal

20080220513 - Device and method for collecting of organic waste: A device and method for collecting organic waste is disclosed. The invention comprises a biodegradable bag that hangs inside a rigid container covered by a perforated lid. A filter lines the inside of the lid which rests on the rim of the rigid container. The biodegradable bag is secured onto... Agent: Asmish G. Airan

20080220514 - Alga microbe photosynthetic reaction system: An alga microbe photosynthetic reaction system is used to circularly cultivate alga microbes and a culture medium infused in the system. The system comprises a photosynthetic reaction unit, a communicating unit, a pressure liquid infusion unit, an injection and oxygen discharging device, and a regulation area. The photosynthetic reaction unit... Agent: Rosenberg, Klein & Lee

20080220515 - Apparatus and methods for production of biodiesel: A photobioreactor includes a cultivation zone configured to contain a liquid culture medium and facilitate growth of a microalgae biomass, a plurality of parallel edge-lit light transmitting devices mounted within the cultivation zone, and a collection zone oriented in relation to the cultivation zone such that at least a portion... Agent: Townsend And Townsend And Crew, LLP

20080220516 - Multi-well micropatterning by ablation: The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20080220517 - Site-specific cell perforation technique: A technique for controlling membrane denaturation reactions other than physical shear force was developed. For example, the present invention provides, a method for causing membrane disruption at a specific site by reacting a stimulus such as light with a compound that is activated by the stimulus, where the reaction occurs... Agent: Nixon Peabody LLP - Patent Group

20080220518 - Method from the selection of biomolecules from biomolecules variant libraries: The invention relates to a method from the selection of biomolecules from variant libraries, in particular of biocatalytically active biomolecules, comprising the steps: a) production of a variant library, b) division of the library into a number of compartments, which is smaller than the total number of variants in the... Agent: Crowell & Moring LLP Intellectual Property Group

20080220519 - Mutated e. coli heat-labile enterotoxin: This invention relates to a mutant E. coli heat-labile enterotoxin (LT) subunit A that can be used as an adjuvant. This subunit A mutant contains an amino acid substitution at a position corresponding to position 61 of a wild-type LT. An LT containing this mutated subunit A exhibits reduced toxicity... Agent: Occhiuti Rohlicek & Tsao, LLP

20080220520 - Cryopreservation of human embryonic stem cells in microwells: The present invention relates to methods and structures for preparing stem cells for use in cryopreservation methods. Stem cell colonies are provided between first and second matrix portions and are exposed to a carbohydrate-containing cryoprotecting medium and a freezing medium. The methods of the invention yield cryopreserved cells that maintain... Agent: Quarles & Brady LLP

20080220521 - Sheet for guiding regeneration of mesenchymal tissue and production method thereof: To provide a sheet for guiding regeneration of mesenchymal tissue having improved formability, strength, absorbability and efficiency, the sheet is produced by steps of containing a culture medium in a surface of a porous sheet produced by freezing a bioabsorbable polymer material dissolved with an organic solvent and drying it,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080220522 - Methods to control cell movement in hollow fiber bioreactors: This invention is directed toward methods of moving cells throughout a hollow fiber bioreactor using fluid flow.... Agent: Gambro Bct, Inc Ip Department

20080220523 - Cell expansion system and methods of use: Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits... Agent: Gambro Bct, Inc Ip Department

20080220524 - Three dimensional gum matrices for cell culture, manufacturing methods and methods of use: This invention relates three dimensional porous cell culture matrices or scaffolds which have directional porous structure. More particularly, this invention relates to three dimensional porous cell culture matrices or scaffolds for cell culture which are derived from or contain gums including naturally occurring gums, plant gums, galactomannan gums or derivatives... Agent: Corning Incorporated

20080220525 - Culture substrate provided with an oxidised silicone coating: i

20080220526 - Gum coatings for cell culture, methods of manufacture and methods of use: This invention relates to coatings for cell culture surfaces. More particularly, this invention relates to coatings for cell culture surfaces which are derived from or contain gums including naturally occurring gums, plant gums, galactomannan gums or derivatives thereof. The invention also relates to articles of manufacture (e.g., cell culture vessels... Agent: Corning Incorporated

20080220527 - Modular transfection systems: The present invention relates to a method for transfection of cells using at least one protein capable of forming nucleoprotein filaments, wherein the protein is initially modified with at least one functional component which influences one or more steps of the transfection, the nucleic acid to be transfected is then... Agent: Joyce Von Natzmer Pequignot + Myers Llc

20080220528 - Hiv gene cloning strategy: The invention relates to methods for cloning Human Immunodeficiency Virus (HIV) genes, in particular HIV envelope genes. The invention also relates to cloning strategies for mapping resistance determinants for HIV genes, in particular HIV envelope genes.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20080213742 - High surface cultivation system: An exemplary embodiment of a reversibly closable vessel suitable for the cultivation of cells and/or tissues can be provided. The exemplary vessel can comprise at least one reversibly closable aperture in the vessel wall, a convection arrangement inside the vessel which can comprise at least one blade. The arrangement can... Agent: Dorsey & Whitney LLP Intellectual Property Department

20080213743 - Method for adjusting sedimentation rates: One or more chemicals are added to a physiological fluid to alter the density and/or shape of cells in the fluid to provide a desired sedimentation rate of the cells. In a preferred embodiment, the chemical to be added is an anticoagulant, preferably ACD.... Agent: Clark & Brody

20080213744 - Method of determining hypoxia: A method of determining hypoxia in fetal scalp blood sampled during labor comprises the determination of total lactate dehydrogenase (LDH) in plasma obtained from the sample. The method can comprise the additional determination of K, Mg, Ca, AST, ALT, lactate in the plasma and/or blood. Increased values of one or... Agent: Alston & Bird LLP

20080213745 - Biomarkers of metabolic responses to hepatotoxicants and carcinogens: Methods for the measurement and prediction of response to hepatotoxicants and carcinogens through the detection of metabolites in a mammal are provided. The metabolites can be used as biomarkers, including efficacy biomarkers, surrogate biomarkers, and toxicity biomarkers. The methods find use for early prediction of toxicity, target identification/validation, and monitoring... Agent: Hutchison Law Group PLLC

20080213746 - Methods of diagnosis and risk stratification of adverse events in post myocardial infarction patients using pro-adrenomedullin: The invention provides methods for the diagnosis and risk stratification of adverse events in post-myocardial infarction patients by means of proADM, whereby a determination of the marker pro-adrenomedullin or partial sequence or a fragment thereof or contained in a marker combination (panel, cluster) is carried out on a post-myocardial infarction... Agent: Connolly Bove Lodge & Hutz, LLP

20080213752 - Bacteriophages as selective agents: Compositions containing bacteriophages and methods of using bacteriophages in microorganism detection assays and microbial growth and plating media are disclosed. The lytic ability of these phages to control the growth of non-target populations provides superior sensitivity and specificity to detection assays and reduces false negative and false positive results. The... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20080213749 - Compositions and methods for detecting human metapneumovirus: Disclosed are oligonucleotides useful in methods for determining whether a sample contains a human metapneumovirus or has an increased likelihood of containing a human metapneumovirus, a virus which is a causative agent of respiratory tract disease in humans. These oligonucleotides, which have nucleotide sequences derived from a coding segment of... Agent: Medical Diagnostic Laboratories LLC

20080213747 - Fluorescent polymer superquenching-based bioassays: A chemical composition including a fluorescent polymer and a receptor that is specific for both a target biological agent and a chemical moiety including (a) a recognition element, (b) a tethering element, and (c) a property-altering element is disclosed. Both the fluorescent polymer and the receptor are co-located on a... Agent: Peacock Myers, P.C.

20080213750 - Hcv variants and related methods: HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive subpassage greater than HCV that have wild-type polyprotein coding regions. Expression vectors comprising the above polynucleotides and HCV variants are also described, as are the... Agent: Thompson Coburn LLP Attn: Richard E. Haferkamp

20080213748 - Method for detection and analysis of macromolecular complexes: V

20080213753 - Method for the verification of the removal of viruses to validate filters and filtering processes: Disclosed is a method for verification of the removal of viruses to validate filters, filtering processes, physical and chemical inactivation processes, or adsorptive removal processes in predefined process conditions that are simulated on a small scale. According to said method, viruses are cultured in suitable cell lines in a first... Agent: Sughrue Mion, PLLC

20080213761 - Agonists of bitter taste receptors and uses thereof: The present invention relates to agonists of the hTAS2R1, hTAS2R3, hTAS2R7 and hTAS2R40 bitter taste receptors, respectively, and their role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or block hTAS2R1, hTAS2R3, hTAS2R7 or hTAS2R40 bitter taste transduction or bitter taste... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080213789 - Assay for detecting methylation status by methylation specific primer extension (mspe): The present invention relates to detecting the relative methylation levels at one or more CpG sites on a nucleic acid molecule, by using the methylation specific primer extension reaction (MSPE). MSPE uses an agent to modify unmethylated cytosine at a CpG site to uracil and subsequently amplify the chemically treated... Agent: Siemens Corporation Intellectual Property Department

20080213769 - Automated method for detecting cancers and high grade hyperplasias: Automated methods for detecting cancer and related hyperplasias in biological samples.... Agent: Kelley Drye & Warren LLP

20080213760 - Compositions and methods for protein isolation: The invention provides for polynucleotides and vectors comprising at least two tag sequences. The invention also provides for polynucleotides and vectors comprising a streptavidin binding peptide sequence and a calmodulin binding peptide sequence. The invention also provides for polynucleotides and vectors wherein a gene of interest is fused in frame... Agent: Agilent Techologies Inc

20080213767 - Detection of nucleic acids by target-catalyzed product formation: A method is disclosed for modifying an oligonucleotide, which method has application to the detection of a polynucleotide analyte. An oligonucleotide is reversibly hybridized with a polynucleotide, for example, a polynucleotide analyte, in the presence of a 5′-nuclease under isothermal conditions. The polynucleotide analyte serves as a recognition element to... Agent: Casimir Jones, S.c.

20080213788 - Gene coding for scytalone dehydratase exhibiting resistance to agricultural fungicidal agent: m

20080213792 - Homogeneous multiplex screening kits: Kits for highly multiplexed homogeneous in vitro screening assays for numerous possible nucleic acid targets, any of which might be present in a sample, that utilize fluorescent hybridization probes that are combinatorially coded from a panel of fluorophores by subdividing each probe into portions and differently labeling each portion such... Agent: Synnestvedt & Lechner, LLP

20080213765 - Human autism susceptibility genes encoding a neurotransmitter transporter and uses thereof: The present invention discloses the identification of a human autism susceptibility gene, which can be used for the diagnosis, prevention and treatment of autism and related disorders, as well as for the screening of therapeutically active drugs. The invention more specifically discloses that the SLC6A1 or SLC6A11 gene on chromosome... Agent: Occhiuti Rohlicek & Tsao, LLP

20080213763 - Human protooncogene and protein encoded by same, and expression vector containing same: Disclosed are a novel protooncogene and a protein encoded by same. The protooncogene of the present invention is a novel gene, and may be effectively used for diagnosing the cancers, including leukemia, uterine cancer, lymphoma, colon cancer, lung cancer, skin cancer, etc., as well as producing transformed animals, etc.... Agent: Cohen, Pontani, Lieberman & Pavane LLP

20080213764 - Human protooncogene and protein encoded therein: Disclosed are a novel protooncogene and a protein encoded therein. The protooncogene of the present invention, which is a novel gene that takes part in human carcinogenesis and simultaneously has an ability to induce cancer metastasis, may be effectively used for diagnosing the cancers, including lung cancer, leukemia, uterine cancer,... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20080213768 - Identification and use of biomarkers for non-invasive and early detection of liver injury: The present invention provides methods for identifying and evaluating suites of biochemical and/or gene entities useful as biomarkers for early prediction of disease and/or toxicity, disease staging, target identification/validation, and monitoring of drug efficacy/toxicity. The present invention further provides suites of small molecule entities as biomarkers for non-invasive and early... Agent: Hutchison Law Group PLLC

20080213791 - Materials and methods for assaying for methylation of cpg islands associated with genes in the evaluation of cancer: Provided are methods, reagents, and kits for evaluating cancer, such as prostate cancer, in a subject. Disclosed methods of evaluating cancer include methods of diagnosing cancer, methods of prognosticating cancer and methods of assessing the efficacy of cancer treatment. The methods include assaying a biological sample for methylation of a... Agent: Leydig Voit & Mayer, Ltd

20080213766 - Method and device for detecting the presence of a single target nucleic acid in samples: A method comprising for each individual sample of a plurality of samples, loading at least one sample portion of the individual sample into at least one respective sample chamber of a plurality of sample chambers, subjecting the sample portions to at least a first amplification step; and then determining whether... Agent: Burr & Brown

20080213755 - Method and device for detection of nucleic acid sequences: A device (420) and method for real-time amplification and detection of a large number of target nucleic acids contained in a large number of biological samples is provided. The device (420) can comprise a substrate (422) and an optically transparent cover, wherein the substrate can comprise a first surface, at... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080213758 - Method for estimating end use qualities of wheat at growth stage: The invention provides a means for estimating the end use qualities of wheat flour that will be obtained in the future from the harvested wheat at an early stage before maturation of the wheat seeds. The invention relates to a method for estimating the end use qualities of a matured... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080213790 - Method for synthesizing polynucleotides: The present invention realized isothermal and rapid polynucleotide synthesis by using as templates polynucleotides having a structure capable of forming loops, and combining a plurality of primers capable of providing a starting point for complementary strand synthesis to such loops. If the LAMP method is applied, all reactions can be... Agent: Nixon Peabody LLP - Patent Group

20080213776 - Method for treating autoimmune diseases and screening method for preventive or therapeutic agent for the same: The present invention is directed to a method for treating autoimmune diseases comprising administering RBAp48 production suppressor or inhibitor; a screening method for a preventive or therapeutic agent for autoimmune diseases comprising determining RBAp48 production suppressing effect or inhibitory effect of a sample; a diagnosis agent or a diagnosing kit... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080213754 - Method of amplifying atp and use thereof: The ATP amplification method of the present invention is a method for amplifying and detecting a very trace amount of exogenous ATP by allowing a fusion protein (PPK-ADK) of a polyphosphate kinase and an adenylate kinase, the fusion protein not containing ADP, to act on a mixture of ATP, AMP,... Agent: Amin, Turocy & Calvin, LLP

20080213770 - Method of determining the nucleotide sequence of oligonucleotides and dna molecules: The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080213762 - Method of gene sequence examination: The present invention provides a method for detecting quantitatively a specific nucleic acid sequence and for detecting gene polymorphism or mutation by homogenous system simply, promptly, accurately, and inexpensively, and an oligonucleotide probe used therefor. The nucleic acid having a specific sequence is quantitatively detected and gene polymorphism or mutation... Agent: Joseph Hyosuk Kim Jhk Law

20080213785 - Method of predicting a benefit of antioxidant therapy for prevention or treatment of vasclar disease in hyperglycemic individuals: This invention relates to methods and compositions of determining the benefit of therapy using antioxidant for the treatment of cardiovascular events in individuals with diabetes mellitus based on their haptoglobin phenotype and the treatment of the cardiovascular events using antioxidants based on the haptoglobin phenotype.... Agent: Pearl Cohen Zedek Latzer, LLP

20080213787 - Methods and compositions for kir genotyping: The present invention provides methods for single nucleotide polymorphism (SNP)-based killer cell immunoglobulin-like receptor (KIR) gene cluster genotyping using the matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer. In general, the methods involve amplifying a plurality of target sequences of a plurality of KIR genes, and detecting the presence or absence... Agent: Bozicevic, Field & Francis LLP

20080213771 - Methods and compositions for large-scale analysis of nucleic acids using dna deletions: The present invention is related generally to analysis of polynucleotides, particularly polynucleotides derived from genomic DNA. The invention provides methods, compositions and systems for such analysis. Encompassed by the invention are constructs that include pairs of target sequences which are separated by a known distance in the polynucleotide from which... Agent: Morgan, Lewis & Bockius, LLP

20080213775 - Methods and materials for identifying polymorphic variants, diagnosing susceptibilities, and treating disease: The invention is directed to materials and methods associated with polymorphic variants in two enzymes involved in folate-dependent and one-carbon metabolic pathways: MTHFD1 (5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase) and methylenetetrahydrofolate dehydrogenase (NADP+dependent) 1-like (MTHFD1L). Diagnostic and therapeutic methods are provided involving the correlation of polymorphic variants in MTBFD1, MTHFD1,... Agent: Leydig, Voit & Mayer, Ltd.

20080213781 - Methods of detecting methylation patterns within a cpg island: A method of increasing sensitivity of a DNA methylation assay by determining complementation within a CpG island of the methylated DNA.... Agent: Philip S. Johnson Johnson & Johnson

20080213757 - Methods of distinguishing types of spinal neurons using corl1 gene as an indicator: As a result of screening for genes that are selectively expressed in fetal mouse brain region by subtraction method, the present inventors obtained a cDNA fragment encoding Corl1. The expression of Corl1 was examined by RT-PCR, in situ hybridization, and immunostaining using polyclonal antibodies. The results demonstrated that Corl1 was... Agent: Townsend And Townsend And Crew, LLP

20080213780 - Multi-color time resolved fluorophores based on macrocyclic lanthanide complexes: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary... Agent: Morgan, Lewis & Bockius LLP (sf)

20080213774 - Mutations in kit confer imatinib resistance in gastrointestinal stromal tumors: The present invention relates to methods and compositions concerning resistance to a drug for cancer comprising aberrant KIT signal, such as aberrant KIT sequence or expression. In a specific embodiment, the cancer is also initially responsive to imatinib therapy, such as in gastrointestinal stromal tumors (GISTs). In particular embodiments, a... Agent: Fulbright & Jaworski, LLP

20080213779 - Nalp7-based diagnosis of female reproductive conditions: Methods, reagents and kits are described for the diagnosis of a female reproductive condition, based on the detection of an alteration in a NALP7-encoding nucleic acid or a NALP7 polypeptide, relative to a corresponding wild-type NALP7-encoding nucleic acid or NALP7 polypeptide.... Agent: Goudreau Gage Dubuc

20080213759 - Novel angiogenesis inhibitor: Because AK022567 has angiogenesis inhibitory activity, it is useful as an angiogenesis inhibitor. Furthermore, 4 splicing variants obtained from the same gene are also useful as an angiogenesis inhibitor. These 5 polypeptides, polynucleotides encoding the polypeptides and antibodies against the polypeptides are useful for screening of a candidate compound as... Agent: Birch Stewart Kolasch & Birch

20080213778 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses: The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of... Agent: Millennium Pharmaceuticals, Inc.

20080213756 - Real-time pcr point mutation assays for detecting hiv - 1 resistance to antiviral drugs: Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase or protease of HIV as disclosed herein. Thus, provided is an oligonucleotide comprising any one of the nucleotide sequences set for in SEQ ID... Agent: Gifford,krass,sprinkle,anderson&citkowsi, PC

20080213784 - Screening methods and sequences relating thereto: wherein the difference comprises a specified variation. The specified variation can be the known mutation in the human MYH protein, G382D-hMYH or a nucleotide sequence encoding it, or it can be one or more novel variations, namely, Y165C, E466X, and Y90X, or the respective corresponding nucleotide sequences. The method is... Agent: Myriad Genetics Inc. Intellecutal Property Department

20080213773 - Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16s ribosomal rna gene and identification of bacterial species by amplicon sequencing: A method for identifying an RNA form of a bacteria, comprising reverse transcribing RNA material; conducting PCR using primers for a first highly conserved genetic sequence generic of the bacteria; conducting nested PCR using primers for a second highly conserved genetic sequence within the first genetic sequence of the bacteria;... Agent: Milde & Hoffberg, LLP

20080213783 - Site-specific enzymatic deposition of metal in situ: The present invention provides compositions, kits, assembles of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In particular, the invention relates to use of enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also... Agent: Wilson Sonsini Goodrich & Rosati

20080213782 - Socs-1 gene methylation in cancer: Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2 protein (CIS) family member (SOCS/CIS) gene such as the SOCS-1 gene. In addition, methods of treating a cancer patient, wherein cancer cells in the patient exhibit methylation-silenced transcription... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP

20080213786 - Treatment of rheumatoid arthritis with galectin-3 antagonists: The invention encompasses a novel method of treating an inflammatory disease, such as rheumatoid arthritis, and novel methods of identifying and screening for drugs useful in the treatment of inflammatory diseases, such as rheumatoid arthritis, and their clinical symptoms. The inventors have made the discovery that the activity of galectin-3,... Agent: Entelos, Inc. C/o Law Offices Of Karen E. Flick

20080213777 - Tumor suppressor pathway in c. elegans: The invention provides novel lin-8, lin-56, and lin-61 genes and polypeptides involved in cell fate determination and in cell proliferation. In addition, the invention includes mutants of these three genes, as well as methods for utilizing these genes, and their encoded polypeptides, in diagnosing and treating abnormal cell proliferation.... Agent: Clark & Elbing LLP

20080213772 - Use of microphthalmia for diagnosis, prognosis and/or treatment of melanoma: Microphthalmia (Mi) while present in melanocytes, a cells and osteoclast, is not normally present in other cells. We have found that Mi is present in the nucleus of melanoma cells. Melanoma can be diagnosed by contacting a malignant cell with a probe for Mi. If the probe identities Mi in... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20080213793 - Antibodies that bind receptor protein designated 2f1: 2F1 polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing the polypeptides. Soluble 2F1 polypeptides find use in inhibiting prostaglandin synthesis and treating inflammation.... Agent: Immunex Corporation Law Department

20080213795 - Dna sequences encoding peptide sequences specific for the hepatic stages of p. falciparum bearing epitopes capable of stimulating the t lymphocytes: The invention discloses isolated DNA sequences encoded by polypeptides characterized by the presence in their structure of one or more sequences bearing all or part of the one or more T epitopes, and possibly other epitopes, particularly B epitopes, characteristic of proteins resulting from the infectious activity of P. falciparum... Agent: Buchanan, Ingersoll & Rooney PC

20080213796 - Gfp-snap25 fluorescence release assay for botulinum toxin protease activity: The present invention provides a nucleic acid molecule which contains a nucleotide sequence encoding a SNAP-25 substrate which includes (i) a green fluorescent protein; (ii) a first partner of an affinity couple; and (iii) a portion of SNAP-25 that includes a BoNT/A, BoNT/C1 or BoNT/E recognition sequence containing a cleavage... Agent: Allergan, Inc.

20080213797 - Immunoassays exhibiting a reduction in prozone phenomena: The present invention relates to immunoassays for detecting or quantifying at least one analyte of interest in a test sample. Specifically, the immunoassays of the present invention exhibit a reduction in prozone phenomena.... Agent: Paul D. Yasger Abbott Laboratories

20080213794 - Screening for gestational disorders: The invention relates to methods and compositions for identifying subjects having, or predisposed to having, gestational diabetes, preeclampsia, and gestational hypertension. The methods are applicable to urine and/or blood samples and can be conducted prior to the third trimester of pregnancy.... Agent: Fish & Richardson PC

20080213799 - Method for detection of substance bound to nuclear receptor: Provided is a detection method including exposing, to contact with a surface to which a cofactor has been bound, a nuclear receptor protein serving as a counterpart of the cofactor and a test sample; and detecting a substance which is contained in the test sample and which binds to the... Agent: Oliff & Berridge, PLC

20080213798 - Novel c. elegans p21-activated kinase (pak) gene and associated loss-of-function phenotypes that facilitate screening for small molecule modulators of pak activity in the nematode, caenorhabditis elegans: The invention refers to a novel C. elegans p21-activated kinase gene, the pak-3 gene, and associated loss-of-function phenotypes. These phenotypes can be used to elucidate PAK signaling pathways in C. elegans and to screen compounds that modulate PAK signaling.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080213803 - Assessment of neurons in the arcuate nucleus to screen for agents that modify feeding behavior: Screening methods of use in identifying agents that affect caloric intake, food intake, appetite, and energy expenditure are disclosed herein. These methods are used to identify agents of use in treating obesity, or that can be used to decrease the weight of a subject. These methods can also be used... Agent: Klarquist Sparkman, LLP

20080213805 - method for distinguishing follicular thyroid adenoma (fta) from follicular thyroid carcinoma (ftc): Follicular thyroid adenoma (FTA) is distinguished from follicular thyroid carcinoma (FTC) by comparing amount of an expression product of at least one gene selected from the group consisting of DDIT3, ARG2, ITM1, Clorf24, TARSH, and ACO1 in a test follicular thyroid specimen to a normal control thyroid specimen. The test... Agent: Banner & Witcoff, Ltd.

20080213804 - Parallel processing fluidic method and apparatus for automated rapid immunohistochemistry: A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a... Agent: Santangelo Law Offices, P.C.

20080213806 - Enriched antibody for detecting mycobacterial infection, methods of use and diagnostic test employing same: The disclosed technology provides an enriched antibody population, highly specific for an antigen of a surface polysaccharide, from a mycobacterium. In a related embodiment, the antibody is enriched by having been raised in an environment that maintains antigenically active antigen. These antibodies may be used in an immunoreactive environment for... Agent: Bromberg & Sunstein LLP

20080213800 - Method for examing interstitital cystitis: It has been found that the urine from an IC patient shows a high value in amount and the existence of activity of an azurophilic granular substance, thereby to establish a method for examining IC. The present invention relates to a method for examining interstitial cystitis using the kinetics of... Agent: Sughrue Mion, PLLC

20080213801 - Monomeric streptavidin muteins: The invention includes a streptavidin mutein having at least one mutation chosen to cause one or more of steric hindrance, charge repulsion, or improvement of solubility by changing interfacial hydrophobic residues to less hydrophobic or hydrophilic residues. The mutein may exist in monomeric form even in the presence of biotin,... Agent: Fulbright & Jaworski L.L.P.

20080213802 - Diagnosis of neurodegenerative diseases: The invention relates to a method of diagnosis of vCJD in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being: beta-actin... Agent: Arent Fox LLP

20080213807 - Methods of using bone morphogenic proteins as biomarkers for determining cartilage degeneration and aging: Methods are provided for determining cartilage degeneration, regeneration, or aging in a joint tissue in a patient by measuring levels of osteogenic protein-1 (OP-1) protein and/or mRNA in synovial fluid or joint tissue. The methods according to the invention are useful for detecting, diagnosing, predicting, determining a predisposition for, or... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP (formerly Kirkpatrick & Lockhart Nicholson Graham)

20080213808 - Mediators for photometric tests and means and methods relating to use thereof: Embodiments of a detection reagent, as well as test elements and analytical kits including such reagent, and methods for using such reagent, are disclosed herein for optical detection and/or measurement of an analyte in a fluid sample.... Agent: Roche Diagnostics Operations Inc.

20080213809 - Stable nad/nadh derivatives: The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of these derivatives and their use in biochemical detection methods and reagent kits.... Agent: Roche Diagnostics Operations Inc.

20080213812 - Methods and compositions for modulating telomerase reverse transcriptase (tert) expression: Methods and compositions are provided for modulating, e.g., increasing or decreasing, the expression of telomerase reverse transcriptase (TERT). In the subject methods, the binding interaction of the TERT Site C repressor site with a Site C repressor protein complex made up of one or more proteins is modulated to achieve... Agent: Bozicevic, Field & Francis LLP

20080213810 - Screening method for hiv rt inhibitors: The present invention is directed to methods for identifying a specific class of inhibitors of HIV reverse transcriptase that act differently from known reverse transcriptase inhibitors. In particular, the invention is based on identifying inhibitors which have higher inhibitory activity in presence of a nucleoside triphosphate or pyrophosphate.... Agent: Philip S. Johnson Johnson & Johnson

20080213811 - Sensor proteins and assay methods: The present invention relates to biosensors. In some embodiments, the biosensors are modified ligand binding molecules. In some embodiments, the modified ligand binding molecule is a phosphate binding protein (PBP). In some embodiments, the modified ligand binding molecules are labeled to be capable of RET, e.g., comprising a donor and... Agent: Invitrogen Corporation C/o Intellevate

20080213813 - Histone deacetylase inhibitor and use thereof: To provide a novel apoptosis inducer, and a method of screening an apoptosis inducer. For example, an apoptosis inducer comprising inhibiting HDAC6 such as an antisense oligonucleotide to the gene of histone deacetylase 6 (HDAC6), and anti-cancer agent comprising this apoptosis inducer, and the present invention also provides a method... Agent: Millen, White, Zelano & Branigan, P.C.

20080213814 - Enzymatic assay for lspr: The present invention provides a method of detecting changes in the refractive index at the surface of a localized surface plasmon resonance (LSPR) detection system. The method includes generating an insoluble product from an enzymatic substrate using an immobilized enzyme, wherein the insoluble product accumulates at a LSPR supporting surface.... Agent: Townsend And Townsend And Crew, LLP

20080213815 - Diagnosing breast cancer by seprase level: A method of diagnosing subjects for breast cancer comprising the steps of (a) establishing the seprase level of a subjects test material and (b) determining those subjects with seprase levels above about 0.0008 nmoles.min−1.mg−1 (by wgt); or above about 0.05 nmoles.min−1.ml−1 (by volume) as positive for breast cancer and other... Agent: Brown Rudnick LLP

20080213816 - Mitochondrial enoyl coenzyme a hydratase 1 as marker for diagnosing stomach cancer: The present invention relates to mitochondrial protein that can be used as a marker for diagnosing stomach cancer. According to the present invention, the marker for diagnosing stomach cancer comprises mitochondrial enoyl coenzyme A hydratase 1.... Agent: Christie, Parker & Hale, LLP

20080213818 - Cellular immunity test with peptides attached to a solid support: The invention concerns a method for detecting cellular immunity (with respect to an antigen), using a solid support whereon is fixed an assortment of peptides constituting T cell epitopes of the antigen to be tested, kits for implementing said method.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080213817 - Enhancement of th2-dependent and inflammatory response: The present invention relates to altering the levels of Th2 cytokine production, and in particular, biasing the cytokine expression profile towards Th2 cytokine production through mitogen-activated protein kinase/ERK kinase kinase 1 (MEKK1), the screening of agents that increase Th2 cytokine production, and the treatment of Th1 associated autoimmune diseases in... Agent: Medlen & Carroll

20080213819 - Device for preparing a body fluid for a bacteriological analysis: The invention concerns a device for preparing a body fluid for a bacteriological analysis thereof comprising a container provided with a chamber (4) wherein a piston (5) is mobile between an opening position and a closing position, the chamber (4) including a separation zone (7) and means for introducing (15,... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20080213820 - Method for determining the selectivity of a pre-synaptic neuromuscular blocking substance: e

20080213823 - Capillary-channeled polymer film flow cytometry: The present invention relates to methods for counting, sorting, and manipulation of cells, organelles, and/or cellular material using capillary-channeled polymer films.... Agent: Needle & Rosenberg, P.C.

20080213822 - Methods for diagnosing celiac sprue and reagents useful therein: Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.... Agent: Bozicevic, Field & Francis LLP Stanford University Office Of Technology Licensing

20080213821 - Microfluidic cell sorter system: A microfluidic system for separating, purifying and counting cell sub-populations, utilising steering of liquid flows in microfluidic channels in a cell focusing region (first dotted circle area); having the integration of the optical detection mechanism and a microchannel structure made from moulding. A master is photolithographically patterned on a soft... Agent: Knobbe Martens Olson & Bear LLP

20080213824 - Synthesis of labeled probes: Improvements in FISH staining employing an aqueous acetonitrile/dimethylsulfoxide mixture in a fluorophore coupling reaction.... Agent: Kelley Drye & Warren LLP

20080213825 - Hyperbaric criogenesis chambers: The Hyperbaric Cryogenesis Chambers are equipment for medical usage, extracorporeal, and capable of promoting the proliferation and preservation of cells in a way mainly microbiologic, “not biologic”. They are compartments with containers that host tissues or cells in solution with nutrients, that bear pressures higher and lower to sea level... Agent: Fulbright & Jaworski, LLP

20080213826 - Compound microbial preparation manufacturing process: A manufacturing process for making compound microbial preparation to improve soil quality, activate soil, effectively degrade soil pollution, and help growth of crops is comprised of having first individual cultivation of multiple single microbial series; each microbial series during the individual cultivation producing multiple life organisms; followed by crossing cultivation... Agent: Troxell Law Office PLLC

20080213828 - Glycoprotein synthesis: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a... Agent: Quine Intellectual Property Law Group, P.C.

20080213827 - Process for producing dipeptides or dipeptide derivatives: t

20080213837 - Apo-3 ligand polypeptide: A tumor necrosis factor and lymphotoxin homolog having apoptotic activity, identified as Apo-3 Ligand, is provided. Nucleic acid molecules encoding Apo-3 Ligand, chimeric molecules and antibodies to Apo-3 Ligand are also provided.... Agent: Genentech, Inc.

20080213830 - Degradable clostridial toxins: The specification discloses modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a Clostridial toxin binding domain; polynucleotide molecules encoding modified Clostridial toxins comprising a PAR ligand domain, a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and a... Agent: Allergan, Inc.

20080213838 - Dna, vector, transformant and method for producing apa protein: In order to recover an active site of the human APA protein (a site in the human APA protein effective in therapy or the like of preeclampsia) in a large quantity and easily, the recombinant human APA protein (hereinafter referred to as a secretory APA) in which the amino acid... Agent: Arent Fox LLP

20080213834 - Gsk3 ligands and polynucleotides encoding gsk3 ligands: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate GSK3 activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or... Agent: Intrexon Corporation

20080213831 - Human cytokine receptor: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor18.”... Agent: Zymogenetics, Inc. Intellectual Property Department

20080213829 - Materials and methods to increase peptide chain expression: DNA sequences that increase peptide chain expression when operably linked to a gene encoding the peptide chain and methods of generating a peptide chain expression host cell using the foregoing are disclosed. Peptide chain expression host cells are also disclosed.... Agent: Philip S. Johnson Johnson & Johnson

20080213839 - Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptides. Other aspects of the invention include vectors containing messes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific... Agent: Robins & Pasternak

20080213833 - Methods for obtaining optically active glycidyl ethers and optically active vicinal diols from racemic substrates: The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific glycidyl ether hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vectors containing such nucleic acid molecules, and cells containing such vectors. Also embraced by the invention are methods for... Agent: Fish & Richardson P.C.

20080213836 - Modified enteropeptidase protein: Disclosed are novel enteropeptidase polypeptides, polynucleotides encoding the polypeptides, nucleotide constructs, vectors, host cells comprising the polynucleotides, and methods for producing the polypeptides and polynucleotides. Such polypeptides are useful as protein engineering tool for enzymatic cleavage of fusion proteins. Also provided are kits comprising the polypeptides of the invention.... Agent: Edwards Angell Palmer & Dodge LLP

20080213835 - Polypeptides having cellobiohydrolase ii activity and polynucleotides encoding same: The present invention relates to polypeptides having cellobiohydrolase II activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid constructs as well as methods for producing and using the polypeptides.... Agent: Novozymes North America, Inc.

20080213832 - Sesquiterpene synthases and methods of use: The invention relates to sesquiterpene synthases and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthases. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of... Agent: Winston & Strawn LLP Patent Department

20080213840 - Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have... Agent: Wilson Sonsini Goodrich & Rosati

20080213841 - Novel method for assembling dna metasegments to use as substrates for homologous recombination in a cell: The invention relates to a novel method for obtaining DNA metasegment comprising ligating adjoining DNA fragments at least 10 Kb in size containing at least one overlapping region.... Agent: Cheryl H Agris Phd

20080213842 - Kit for synthesizing polynucleotides: The present invention realized isothermal and rapid polynucleotide synthesis by using as templates polynucleotides having a structure capable of forming loops, and combining a plurality of primers capable of providing a starting point for complementary strand synthesis to such loops. If the LAMP method is applied, all reactions can be... Agent: Nixon Peabody LLP - Patent Group

20080213843 - Glucoamylase variants: The invention relates to a variant of a parent fungal glucoamylase, which exhibits altered properties, in particular improved thermal stability and/or increased specific activity.... Agent: Novozymes North America, Inc.

20080213751 - Ilcs based pattern recognition of sepsis: The present invention refers to a method for recognizing and/or characterizing cellular activity patterns, in particular for diagnostic purposes and/or for tracking the therapy of diseases. Blood cells are stimulated in a culture medium at least with toll-like receptor ligands (TLR ligands) and the stimulated blood cells and/or the culture... Agent: Foley And Lardner LLP Suite 500

20080213844 - Dura substitute and a process for producing the same: The invention relates to dura substitutes to be used as prostheses for dural defects in the field of neurosurgery and processes for producing the same. The present invention provides artificial dura mater materials comprising sheets of microbial-derived polysaccharide processed to have the necessary strength characteristics, conformability and physical properties.... Agent: Woodcock Washburn LLP

20080213845 - Method to increase the yield and improve purification of products from transaminase reactions: A process for producing high yields of enantioselective amino acids and chiral amines by reacting a keto acid or ketone and an amino acid donor in the presence of a transaminase biocatalyst to produce a keto acid by-product and an amino acid or amine product. Further reacting the keto acid... Agent: Rockey, Depke & Lyons, LLC

20080213846 - Method of production of para-hydroxycinnamic acid using a thermostable tal enzyme: A thermostable TAL enzyme was identified from the fungus Phanerochaete chrysosporium, which has high activity at temperatures of 40° C. to about 60° C. The enzyme was produced in engineered cells and used for production of para-hydroxycinnamic acid (pHCA) from tyrosine. When the pHCA production reaction was run at high... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080213847 - Process for producing prenyl alcohols: A method of producing a prenyl alcohol(s) by culturing a mutant cell into which a fusion gene of farnesyl diphosphate synthase gene and geranylgeranyl diphosphate synthase gene has been introduced and recovering the prenyl alcohol(s) from the resultant culture.... Agent: Kenyon & Kenyon LLP

20080213848 - Methods for increasing the production of ethanol from microbial fermentation: A stable continuous method for producing ethanol from the anaerobic bacterial fermentation of a gaseous substrate containing at least one reducing gas involves culturing in a fermentation bioreactor anaerobic, acetogenic bacteria in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor; and manipulating the bacteria in the bioreactor... Agent: Howson And Howson

20080213849 - Ethanol production from solid citrus processing waste: Method for producing ethanol from solid citrus waste by reducing the concentration of limonene in citrus waste to allow fermentation. In one embodiment ground solid citrus waste is partially hydrolyzed and pasteurized by heating using a jet cooker and then injected into a flash tank to remove limonene. The heated... Agent: Usda, Ars, Ott

20080213850 - Pretreatment of waste mushroom bed and method of converting the same to yield sugars and ethanol: It is an objective of the present invention to develop a method of pretreating a waste mushroom bed so as to easily and efficiently obtain sugars and ethanol with the use of such waste mushroom bed. It is another objective of the present invention to develop a method of converting... Agent: Davidson, Davidson & Kappel, LLC

20080213851 - Enzymatic method for producing bioactive, osteoblaststimulating surfaces and use thereof: The invention relates to a method for producing bioactive surfaces by enzymatic modification of molecules or molecular aggregates, in particular, collagen, on surfaces of glass, metals, metallic oxides, plastics, biopolymers or other materials with an amorphous silicon dioxide (silica) or silicones in the cell culture, by tissue engineering or in... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080213852 - Novel gene sts 18: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, PC

20080213853 - Magnetofluidics: Magnetofluidic systems and techniques. In one aspect, a magnetofluidic device includes a superhydrophobic surface and a fluid sample in physical contact with the superhydrophobic surface, the fluid sample comprising a collection of particles coated with a passivating layer. The particles are magnetically active in that they respond to an applied... Agent: Fish & Richardson, PC

20080213854 - Device and method for stabilising the flow through a chamber: A device 1 with at least one electrode 8 for generating an electrical field in a chamber 7 is disclosed. The device 1 comprises at least one input channel 6 for introducing a fluid into the chamber 7, and at least one output channel 11 for discharging the fluid from... Agent: Joyce Von Natzmer Pequignot + Myers LLC

20080213855 - Planar electroporation apparatus and method: An electroporation apparatus provides for the electroporation of adherent cells attached to an electrode surface or suspended cells in close proximity to an electrode surface. In one embodiment, the electrodes are transparent to allow cell viewing using a microscope or an automated image analysis machine. The geometry of the electrodes... Agent: Parteq Research & Development Innovations

20080213856 - Method and device for isolating micro-organisms: A process for isolating at least one micro-organism from a medium including a) introducing a selected quantity of magnetic or magnetizable particles into a sample of the medium; b) incubating the particles and the medium for a time sufficient for the micro-organisms to develop and adhere to surfaces of the... Agent: Ip Group Of Dla Piper US LLP

20080213857 - Patterning substrate and cell culture substrate: In order to attain the object, the invention provides a patterning substrate comprising a base material, a photocatalyst-containing layer which is formed on the base material and comprises at least a photocatalyst, and a cell adhesion-inhibiting layer which is formed on the photocatalyst-containing layer and comprises a cell adhesion-inhibiting material... Agent: Ladas & Parry LLP

20080213858 - Stabilization of enzymes: A process for producing enzymes structures includes providing an emulsion of droplets of a first liquid phase dispersed in a second liquid phase. The one liquid phase is a hydrophilic phase, while the other liquid phase is a hydrophobic phase which is immiscible with the hydrophilic phase. Enzyme molecules are... Agent: Knobbe Martens Olson & Bear LLP

20080213859 - Methods for the reduction of stutter in microsatellite amplification: The invention provides a method for reducing stutter in the amplification of a microsatellite comprising the steps of providing a sample comprising a microsatellite having a G+C content of 50% or less; contacting the sample with at least one enzyme having nucleic acid polymerase activity; and incubating the sample with... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080213860 - Nicking endonuclease methods and compositions: A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or gutamic acid corresponding to position 507 and position 546 respectively in SEQ ID NO:6.... Agent: Harriet M. Strimpel, D. Phil.

20080213861 - Methods and compositions for rna interference: The present invention provides methods for attenuating gene expression in a cell, especially in a mammalian cell, using gene-targeted double stranded RNA (dsRNA), such as a hairpin RNA. The dsRNA contains a nucleotide sequence that hybridizes under physiologic conditions of the cell to the nucleotide sequence of at least a... Agent: Ropes & Gray LLP

20080213862 - Polypeptides having alpha-amylase activity and polynucleotides encoding same: The present invention relates to polypeptides having alpha-amylase activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to a polypeptide having carbohydrate-binding affinity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors,... Agent: Novozymes North America, Inc.

20080213863 - Method of controlling viral outbreak: Disclosed is a novel application for β-cyclodextrin (β-CD, a cholesterol depletor), and a novel technique for the creation of immunogens. Topical application of β-CD inhibits or reduces the severity of viral outbreaks such as oral or genital herpes by disrupting lipid rafts, through which viral entry and outbreak occur. Viral... Agent: Chester G. Moore Baker, Donelson, Bearman, Caldwell & Berkowitz, PC

20080213864 - Apparatus for producing and handling a flowing substance: A system (1) for producing a dough starter culture is provided which comprises a plurality of reservoirs (15) pre-loaded with a small amount (“mother level”) of a previously obtained starter culture. Into the reservoirs (15) are inoculated the other ingredients required for the preparation of starter culture and the contents... Agent: Baker, Donelson, Bearman, Caldwell & Berkowitz

20080213865 - Compound microbial preparation: A compound microbial preparation includes multiple single microbial series, hormones produced from each of those multiple single microbial series separately cultivated, and hormones produced from cross cultivation among those multiple single microbial series to be applied in modifying soil quality, activating soil, effectively degrading soil pollution, and helping growth of... Agent: Troxell Law Office PLLC

20080213867 - Liquid media for chlamydospore production of the fungus pochonia chlamydsporia: This invention refers to the creation of liquid media to grow the fungus Pechonica chlamydosporia designed to produce conidia of the aleuriospore type, also denominated chlamydospores. These media using easily carried out fermentation processes, achieved productions over 106 chlamydospores/ml. The chlamydospores can then be easily extracted using processes of filtration... Agent: Sughrue Mion, PLLC

20080213866 - Method for preparing an expanded product for fermentation: i

20080213868 - Concentrated aqueous suspensions of microalgae: The invention relates to a method and apparatus for concentrating an aqueous suspension of microalgae. The suspension of microalgae is passed through a tangential filtering device for partially removing water from the suspension without rupturing the microalgae, thereby obtaining a concentrated suspension of microalgae and filtered water. Such a method... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20080213869 - Hydrogel for separating cell and method of separating cell: Cell/organism is separated by using a hydrogel capable of selectively moving a cell in accordance with a difference in the concentration of a physiologically active substance. The invention provides a hydrogel capable of conducting separation (fractionation, differential separation, fractional collection) of cell/organism having a variety of taxes, which could not... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080213870 - Methods for obtaining modified dna from a biological specimen: The present invention provides a method for obtaining modified DNA from a biological specimen by obtaining a cell suspension from the specimen, if necessary; passing the cell suspension through a first filter under conditions sufficient to obtain filter-bound cells and suspended DNA; lysing the filter-bound cells under conditions sufficient to... Agent: Philip S. Johnson Johnson & Johnson

20080213871 - Altering regulation of maize lignin biosynthesis enzymes via rnai technology: The present invention relates to compositions and methods for providing RNA Interference (RNAi) vectors comprising maize lignin biosynthesis enzymes for altering lignin content of plants. Specifically, plants comprising RNAi maize lignin vectors for reducing or altering lignin content are provided for reducing pretreatment costs of biofuel production. Additionally, RNAi maize... Agent: Peter G. Carroll Medlen & Carroll, LLP

20080213872 - Disposable and removable nucleic acid extraction and purification cartridges for automated flow-through systems: Removable cartridges are used on automated flow-through systems for the purpose of extracting and purifying genetic material from complex matrices. Different types of cartridges are paired with specific automated protocols to concentrate, extract, and purifying pathogenic or human genetic material. Their flow-through nature allows large quantities sample to be processed.... Agent: Lawrence Livermore National Security, LLC

20080213873 - Laboratory apparatus with two cabinets: A laboratory apparatus for use in IVF treatment of infertility comprises first (10) and second cabinets (11) interconnected by a passageway (12) and a closure for closing said passageway. The first cabinet has an open front wall (13) and is arranged to allow air to be circulated within the cabinet... Agent: Fulwider Patton LLP

20080213874 - Weight measurements of liquids in flexible containers: Articles and methods for measuring weight of a liquid in a disposable bag bioreactor are presented. In certain embodiments, bioreactor systems described herein include a supported container (e.g., a flexible bag in a reusable housing) for containing a liquid, and at least two pressure indicating sensors operatively associated with the... Agent: Wolf Greenfield & Sacks, P.C.

20080213875 - Assay devices and methods: A device for determining an assay result may include a test strip, a light source system, a light detection system, and a processor.... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080213876 - Composting apparatus: A composting apparatus is disclosed which comprises a container (10) formed from a plurality of segments (12a, 12b and 12c). An aerator (20, 521) is located in the container for receiving air from the exterior of the container and distributing the air into the composting mass within the container. The... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080213877 - Filtration device for biological samples: An open-topped container (10) is sealed by a cap (12) to the underside of which is fixed a sealed enclosure (13) containing a fixative solution. At the end of the enclosure remote from the cap is a receptacle (14) for a faecal specimen and this is surrounded by protrusions (15)... Agent: Young & Thompson

20080213878 - Novel human membrane proteins and polynucleotides encoding the same: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.... Agent: Lexicon Pharmaceuticals, Inc.

20080213879 - Chimeric gfp-aequorin as bioluminescent ca++ reporters at the single cell level: A modified bioluminescent system comprising a fluorescent molecule covalently linked with a photoprotein, wherein said link between the two proteins has the function to stabilize the modified bioluminescent system and allowing the transfer of the energy by Chemiluminescence Resonance Energy Transfer(CRET).... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080213880 - Chimeric t1r1 taste receptor encoding nucleic acid sequences and vectors: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department

20080213881 - Isolated nucleic acid molecules which encode t cell inducible factors (tifs), the proteins encoded, and uses thereof: The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the... Agent: Wyeth/finnegan Henderson, LLP

20080213882 - Method for isolating dermal papilla cells and uses thereof: The present invention relates to dermal papilla-specific markers and a method for isolating dermal papilla cells using the same. Dermal papilla cells isolated in accordance with the method of the invention and treated with BMP6 are useful for promoting hair growth.... Agent: Licata & Tyrrell P.C.

20080213883 - Silica nanoparticles in basic amino acid-silica sols: In general, in one aspect, the invention features a method that includes preparing a mixture comprising water, a basic amino acid, and a metal oxide precursor under conditions which result in the formation of metal oxide nanoparticles from the metal oxide precursor.... Agent: Fish & Richardson PC

20080213884 - Vectors for tissue-specific replication: The invention generally relates to targeted gene therapy using recombinant vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional vectors and methods for using them. Such vectors are able to selectively replicate in a target tissue to provide a therapeutic benefit from the presence of the vector per... Agent: Ropes & Gray LLP

20080213885 - Composition and method for enabling proliferation of pluripotent stem cells: The present disclosure is directed to the development of compositions, such as extracellular matrices, and processes for using the same, for culturing stem cells in vitro in an undifferentiated state. In this regard, it has been discovered that when pluripotent mouse and human embryonic stem cells are cultured on plates... Agent: Fay Sharpe LLP

20080213886 - Albumin fusion proteins: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080213887 - Methods and compositions for cryopreserving oocytes: Disclosed are methods and compositions useful for cryopreserving oocytes and, in particular, mammalian oocytes such as human oocytes.... Agent: Foley & Lardner LLP

20080213888 - Neural precursor cells, method for the production and use thereof in neural defect therapy: The invention relates to isolated and purified neural precursor cells, to methods for the generation of such precursor cells in unlimited quantities from embryonic stem cells, and to their use for the therapy of neural defects, particularly in mammals, preferably in human beings, and for the generation of polypeptides.... Agent: Wilmerhale/boston

20080213890 - Antibody-avidin fusion proteins as cytotoxic drugs: Methods and compositions for inducing apoptosis and/or inhibiting proliferation of cells. The method includes exposing the cells to a cytotoxic agent which is made up of a targeting moiety and an avidin moiety wherein the targeting moiety is capable of binding to one or more receptors located on the cells.... Agent: Quine Intellectual Property Law Group, P.C.

20080213889 - Inhibitors of phosphodiesterases in infertility: The present invention is directed to methods of increasing oocyte production in a mammal. More specifically, the specification describes methods and compositions for inducing follicular maturation using a PDE inhibitor. The inhibitor may be used alone at high doses. Alternatively, the follicular maturation is achieved by combining a low dose... Agent: Howrey LLP - Dc

20080213891 - Rnai agents comprising universal nucleobases: One aspect of the present invention relates to an oligonucleotide agent comprising at least one universal nucleobase. In certain embodiments, the universal nucleobase is difluorotolyl, nitroindolyl, nitropyrrolyl, or nitroimidazolyl. In a preferred embodiment, the universal nucleobase is difluorotolyl. In certain embodiments, the oligonucleotide is double-stranded. In certain embodiments, the oligonucleotide... Agent: Foley Hoag, LLP

20080213892 - Self-renewal of neural stem cells is promoted by wnt proteins: Mammalian neural progenitor or stem cells are expanded in vitro by culture in the presence of one or more wnt polypeptides. The expanded cells substantially maintain their original phenotype including the ability to give rise to multiple types of differentiated cells.... Agent: Bozicevic, Field & Francis LLP

20080213893 - Isolation of neural stem cells using gangliosides and other surface markers: During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem cells (RSCs). The NSC-specific markers identified included... Agent: Knobbe Martens Olson & Bear LLP

20080213894 - Disposable tubing set for use with a cell expansion apparatus and method for sterile sampling: A disposable apparatus for cell expansion, having at least one bioreactor. The bioreactor has a cellular growth area and a supply area, the cellular growth area being separated from said supply area by a membrane. A fluid recirculation path in fluid communication with the cellular growth area allows for hermetically... Agent: Gambro Bct, IncIPDepartment

20080213895 - Method for culturing dendritic cells (dc) and cytokine-induced killer cells (d-cik) and applications thereof: A mass production of dendritic cells (DC) and cytokine-induced killer cells (D-CIK) cells from the umbilical cord blood or peripheral blood via the activation with a cellular activator “Koyo” derived from the purified tumor cells during the aggregation and proliferation of the purified tumor cells is provided. A preparation of... Agent: J.c. Patents

20080213896 - Methods for storing conifer somatic embryo germinants: In one aspect, the present invention provides methods of storing conifer somatic embryo germinants germinated oil a sterile germination medium for delayed transplanting into a growth medium. The methods of the invention comprise the steps of: (a) placing the germinants while still on sterile germination medium into a cold environment... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

20080213897 - Methods for storing conifer somatic embryo germinants: In one aspect, the present invention provides methods of storing conifer somatic embryo germinants germinated on a sterile germination medium for delayed transplanting into a growth medium. The methods of the invention comprise the steps of: (a) placing the germinants while still on sterile germination medium into a cold environment... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

20080213898 - Compositions and methods for nucleic acid delivery: Compositions and methods are described for non-viral nucleic acid delivery. A targeting peptide capable of mediating targeting to a cell or subcellular compartment is derivatized with a photoaffinity label. Following an ionic interaction with a polynucleotide, such as DNA, and photolysis, the bioactive peptide becomes covalently attached to the DNA.... Agent: Foley & Lardner LLP

20080213900 - Engineered protein kinases which can utilize modified nucleotide triphosphate substrates: Engineered protein kinases which can utilize modified nucleotide triphosphate substrates that are not as readily utilized by the wild-type forms of those enzymes, and methods of making and using them. Modified nucleotide triphosphate substrates and methods of making and using them. Methods for using such engineered kinases and such modified... Agent: Morgan Lewis & Bockius LLP

20080213899 - Rotationally oscillating injector: A microinjection device is provided that includes an injection element defining a longitudinal axis, and that further includes a motor. The injection element is rotatable about the longitudinal axis by the rotational motor. The injection element is for penetrating a target, such as a cell. A microinjection system is provided... Agent: Mccarter & English , LLP Stamford Office

20080213901 - Methods for producing heterologous polypeptides in trichothecene-deficient filamentous fungal mutant cells: The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the polypeptide, wherein (i) the mutant cell comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence... Agent: Novozymes, Inc.