Chemistry: molecular biology and microbiology inventions 08/08

20080206734 - High surface cultivation system with filler: An exemplary embodiment of a reversibly closable vessel suitable for the cultivation of cells and/or tissues can be provided. The exemplary vessel can comprise at least one reversibly closable aperture in the vessel wall, at least one wall provided in the interior of the vessel, with the wall being an... Agent: Dorsey & Whitney LLP Intellectual Property Department

20080206735 - High surface cultivation system with surface increasing substrate: An exemplary embodiment of a culture vessel suitable is provided for a cultivation of cells and/or tissues. The exemplary vessel comprising at least one reversibly closable aperture in the vessel wall, and at least one surface-increasing substrate within the vessel, with the substrate being made of a single mold. According... Agent: Dorsey & Whitney LLP Intellectual Property Department

20080206733 - Method of inducing differentiation of embryo-stem cell into hepatocyte and hepatocyte induced by the method: With respect to a method for differentially inducing embryo-stem cells into hepatocytes, in order to obtain safe hepatocytes that are adequately functionable and able to supply in large quantity, a method for differentially inducing embryo-stem cell into hepatocyte, wherein the embryo-stem cells are cultured in the presence of deletion type... Agent: Nath & Associates

20080206736 - Flavin n-oxides: new anti-cancer agents and pathogen eradication agents: Compounds comprising flavin N-oxides for treatments of solid tumors, non-solid tumor masses, leukemias, and non-small cell lung cancers and for eradicating contaminants in blood products. Methods of treating patients having solid type cancers comprising administering a therapeutically effective amount of a flavin N-oxide to a subject in need of treatment... Agent: Calfee Halter & Griswold, LLP

20080206739 - Analysis method for pesticide residues in plant samples: The invention relates to an analysis method for pesticide residues in plants. The method uses the interface device for the direct coupling of liquid chromatography and gas chromatography, called the TOTAD (Through Oven Transfer Adsorption Desorption) interface in scientific literature. The method only requires an extraction step prior to the... Agent: Ostrolenk Faber Gerb & Soffen

20080206738 - Compositions and methods for modulating s-nitrosoglutathione reductase: Disclosed herein are methods and compositions for modulating the levels and/or activity of S-nitrosoglutathione reductase (GSNOR) in vivo or in vitro. Specifically disclosed are GSNOR deletion constructs, host cells and non-human mammals comprising GSNOR deletions, and methods of screening employing GSNOR deletion mutants. Also specifically disclosed are reagents and procedures... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080206737 - Expression quantification using mass spectrometry: In various aspects, the present teachings provide systems, methods, assays and kits for the absolute quantitation of protein expression. In various aspects, the present teachings provide methods of determining the concentration of about the top forty-one proteins present in human plasma. In various aspects, the present teachings provide methods of... Agent: Ambion

20080206742 - Inhibition of hiv-1 virion production by a transdominant mutant of integrase interactor 1 (ini1)/hsnf5: Peptides comprising an Rpt1 domain of an INI1/hSNF5 which inhibit HIV-1 production in a human cell, and vectors encoding those peptides are provided. Also provided are methods of inhibiting HIV-1 production in a cell, or spread of the HIV-1 to another cell, by treating the cells with the above peptides... Agent: Amster, Rothstein & Ebenstein LLP

20080206740 - Sampling method and device: Disclosed herein is test device and method for detection of sample analytes in which after sampling has occurred a closure is provided. Such a test device and method can be usefully employed to detect a variety of analytes including microorganisms.... Agent: Richard J. Long Charm Sciences, Inc.

20080206741 - Virus recovery medium, use thereof and viral diagnostic kit including same: The present invention relates to a virus recovery medium and a viral diagnostic kit comprising the same. The virus recovery medium is supplemented with a hormone and an enzyme. The hormone is preferably a glucocorticoid hormone, more preferably dexamethasone. The enzyme is preferably a protease, more preferably trypsin.... Agent: Brooks Kushman P.c.

20080206774 - Automated cancer diagnostic methods using fish: In various embodiments methods for automated screening for gene amplification in biological tissue samples using an automated fluorescence microscope to analyze fluorescence in situ hybridized samples are provided. Various additional embodiments provide methods of high throughput screening for gene amplification.... Agent: Kelley Drye & Warren LLP

20080206756 - Biomarker panel for colorectal cancer: A panel of biomarkers has been identified for analysis of colorectal cancer. The panel, originally identified using a mouse colon cancer model, has been used to assess changes in human tissue from surgical and biopsy samples against a normal human control panel of biomarkers. The panel may be used for... Agent: Buchanan, Ingersoll & Rooney LLP

20080206766 - Compositions and methods for detecting and treating prostate disorders: The present invention relates to compositions and methods for the detecting, treating, and empirically investigating cellular proliferation disorders and cellular motility disorders. In particular, the present invention provides compositions and methods for using CXCL chemokines (e.g., CXCL1, CXCL5, CXCL6, CXCL12), CXCL receptors (e.g., CXCR1, CXCR2, CXCR4, CXCR7), and/or pathway related... Agent: Casimir Jones, S.c.

20080206773 - Dna fingerprinting using allelic specific oligonucleotide reversed dot blot (aso-rdb) flow through hybridization process and device: The present invention disclosed the use of single nucleotide polymorphism (SNP) as the detection assay for human identification. Using the reversed dot-blot format and the flow through hybridization process, the process can be more efficient, less expensive and with similar or better power of exclusion in definitive identification. The present... Agent: Law Offices Of Albert Wai-kit Chan, Pllc

20080206761 - Ex vivo gene expression in whole blood as a model of assessment of individual variation to dietary supplements: A method is disclosed for individually tailoring the administration of dietary components such as supplements. In the method, whole blood of a mammal is exposed to a dietary component. The level of a marker mRNA linked to a disease state is measured in leukocytes after exposure to the dietary component,... Agent: Knobbe Martens Olson & Bear LLP

20080206778 - Feline hemoplasma isolate: A newly identified hemoplasma agent, Candidatus Mycoplasma turicensis, is disclosed. Also disclosed are detection methods, screening methods and methods of diagnosis for the hemoplasma agent.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080206764 - Flowcell system for single molecule detection: The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection... Agent: Townsend And Townsend And Crew, LLP

20080206744 - Functional genomics and gene trapping in haploid or hypodiploid cells: The present invention provides methods and compositions for performing functional genomics and gene trapping using haploid cells, including haploid or hypodiploid vertebrate cells. The present invention further provides methods for identifying genes involved in cellular signaling pathways.... Agent: Foley & Lardner LLP

20080206777 - Gene and protein expression profiles associated with the therapeutic efficacy of egfr-tk inhibitors: The present invention provides protein and gene expression profiles indicative of whether a patient afflicted with non-small cell lung cancer is likely to be responsive to treatment with a therapeutic compound that is a EGFR-TK inhibitor. By identifying such responsiveness, a treatment provider may determine in advance those patients who... Agent: Paula C. Evans Nuclea Biomarkers, Llc

20080206759 - Gene regulatory networks and methods of interdiction for controlling the differentiation state of a cell: The invention provides a method of modulating a regulatory state of a cell. The method consists of: (a) identifying a point of interdiction within a cis regulatory network specifying a genetic regulatory architecture of a cell, and (b) introducing into a progenitor cell two or more network elements within said... Agent: Ropes & Gray LLP

20080206751 - Method for carrying out a multi-step reaction, breakable container for storing reagents and method for transferring solid reagent using an electrostatically charged wand: The application relates to a method of performing a multi-step reaction vessel (68) having at least two compartments (685, 680). The reagents are placed in the first compartment (685) and moved to second one (680) by centrifugation, after which another set of reagents may be placed in the first compartment... Agent: Polsinelli Shalton Flanigan Suelthaus Pc

20080206760 - Method for detecting dna methylation using labelled s-adenosylmethionine analogs: The invention relates to a method for detecting the methylation status in DNA samples. According to the invention, a DNA methyl transferase and a labeled S-adenosylmethionine derivative allow a detectable label to be covalently bonded to the DNA, in accordance with the respective methylation status of the DNA sample.... Agent: Kriegsman & Kriegsman

20080206755 - Method for genetic detection using interspersed genetic elements: The way to design a “filled” site (which contains an interspersed element) primer set to target a particular locus is to design one of the two primers such that it encompasses that unique information (e.g., interspersed element+flanking genomic sequence+direct repeat). The way to design an “empty” site primer is to... Agent: Robert E. Bushnell Suite 300

20080206754 - Method for producing monoclonal antibodies: An improved method for the production of monoclonal antibodies is disclosed.... Agent: Wyeth/finnegan Henderson, LLP

20080206771 - Method for recovering nucleic acid from a mixed cell suspension, without centrifugation: A method for selectively recovering nucleic acid from a first cell type in a sample containing cells of at least a first cell type and a second cell type, and a cell suspension medium comprising extracellular impurities, is provided. The method entails combining the sample with particles responsive to a... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080206762 - Method for the diagnosis of alzeimer's disease: The invention relates to a method for the diagnosis and/or prognosis of Alzheimer's disease, consisting in determining the expression level of a gene encoding a lysosomal marker.... Agent: Katten Muchin Rosenman LLP

20080206752 - Method for the photochemical attachment of biomolecules to a substrate: Methods and devices for attaching biomolecules to a solid substrate surface for example to the inner surface of a capillary. In particular, the invention relates to compounds and methods for creating patterned arrays of biomolecules inside fused silica capillaries so that a plurality of bioassays can be conducted simultaneously.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080206775 - Method of amplifying nucleic acids, reagent kit for amplifying nucleic acids, method of detecting single nucleotide polymorphism, and reagent kit for detecting single nucleotide polymorphism: An object of the present invention is to provide a nucleic acid amplification method for amplifying a desired nucleic acid while suppressing amplification of byproducts in a PCR reaction, a reagent kit used for nucleic acid amplification, a method of detecting single nucleotide polymorphism to detect single nucleotide polymorphism by... Agent: Buchanan, Ingersoll & Rooney Pc

20080206757 - Methods and compositions for detecting rare cells from a biological sample: The present invention provides methods and compositions for isolating and detecting rare cells from a biological sample containing other types of cells. In particular, the present invention includes a debulking step that uses a microfabricated filters for filtering fluid samples and the enriched rare cells can be used in a... Agent: Morrison & Foerster LLP

20080206749 - Methods and kits for diagnosis, prognosis or monitoring of epstein-barr virus (ebv)-associated cancer: Disclosed is a non-invasive method for diagnosis, prognosis or monitoring of Epstein-Barr virus (EBV)-associated cancer by detecting and/or quantifying EBV associated nucleic acid fragments in a urine sample from an individual. Kits for diagnosis, prognosis or monitoring of cancer are also disclosed.... Agent: Seed Intellectual Property Law Group Pllc

20080206779 - Methods and kits for multiplex hybridization assays: The invention provides a method for genotyping interfering polymorphic loci in a target polynucleotide, such as a strand of genomic DNA, in a multiplex hybridization-based assay. The invention also provides nucleic acid standards for validating the performance of such hybridization-based assays. In one aspect, the method of the invention is... Agent: Affymetrix, Inc Attn: Chief Ip Counsel, Legal Dept.

20080206753 - Methods for cancer prognosis: A method for assessing prognosis in a subject having a breast tumor comprises determining the level of expression of at least one Notch receptor gene, Notch ligand gene or Notch signaling target gene. A method of treating a subject suffering from a breast tumor associated with increased Notch signaling comprises... Agent: Myers Bigel Sibley & Sajovec

20080206748 - Methods for genetic analysis of dna to detect sequence variances: Methods for determining genotypes and haplotypes of genes are described. Also described are single nucleotide polymorphisms and haplotypes in the ApoE gene and methods of using that information.... Agent: Fish & Richardson Pc

20080206763 - Methods for isolating and characterizing endogenous mrna-protein (mrnp) complexes: Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex and include cell cultures, cell extracts, and whole tissue, including tumor... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080206747 - Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation: This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.... Agent: Applied Biosystems

20080206765 - Mn gene and protein: Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked... Agent: Leona L. Lauder

20080206769 - Molecular prognostic signature for predicting breast cancer distant metastasis, and uses thereof: The present invention is based on the discovery of a unique 14-gene molecular prognostic signature that is useful for predicting breast cancer metastasis. In particular, the present invention relates to methods and reagents for detecting and profiling the expression levels of these genes, and methods of using the expression level... Agent: Celera, An Applera Business Unit

20080206750 - Novel fetal genes: Novel fetal genes (fls353 and fls485) have been successfully isolated from human fetal liver-derived cDNAs. These genes were specifically expressed in tissues including fetal tissues which are thought to contain a large number of undifferentiated cells and actively differentiating/proliferating cells. High levels of expression of these genes were observed also... Agent: Fish & Richardson Pc

20080206745 - Nucleic acid extraction solution and use thereof: Disclosed are methods and compositions for extracting nucleic acids from a biological sample. In particular, disclosed is a nucleic acid extraction solution together with methods using such a solution for extracting nucleic acid sequences from biological samples containing cells, cellular debris or both. The nucleic acid extraction solution contains a... Agent: Theodore Allen Cytyc Corporation

20080206746 - Plasmid dna isolation: Apparatus, reagents, and methods for isolating plasmid DNA from bacteria by alkaline lysis using a solid or immobilized P2 and/or P3 reagent in combination with a DNA-binding matrix.... Agent: Jonathan Claypool

20080206758 - Polynucleic acid-attached particles and their use in genomic analysis: Disclosed are methods for preparing particle-linked polynucleotides, and using the particle linked polynucleotides in genomic analysis. The particles as disclosed are characterized as having a size variance of less than 2%.... Agent: Woodcock Washburn LLP

20080206768 - Predicting a response to olanzapine: The invention relates generally to the relative effect of specific genetic polymorphisms in predicting the clinical outcome of olanzapine therapy in patients suffering from a psychiatric disease such as schizophrenia.... Agent: Edwards Angell Palmer & Dodge LLP

20080206743 - Rapid and specific detection of enterobacter sakazakii: The present invention provides a method for specifically detecting pathogenic Enterobacter sakazakii in a complex sample. The complex sample can be a food sample, water sample, or selectively enriched food matrix. The method of detection may utilize PCR amplification with, or without, an internal positive control, and appropriate primer pairs.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080206772 - Sample treatment solution and reagent kit for preparing sample for detecting dna methylation: The present invention provides a sample treatment solution for preparing a sample for DNA methylation which can achieve stable detection results in detection of DNA methylation and be easily pretreated, comprising an aqueous solution containing a protease.... Agent: Sughrue Mion, Pllc

20080206770 - Screening methods used to identify compounds that modulate skin stromal cells (fibroblasts) ability to modify function of extracellular matrix: The cellular response to cosmetic products has been characterized on the molecular level through the use of gene and protein expression technologies. Nucleic acid and protein molecules, the expression of which are induced or repressed in response to exposure to cosmetics, are identified according to a temporal pattern of altered... Agent: Biotech Beach Law Group , Pc

20080206767 - System and method for tracking and controlling infections: The present invention is a system and method for performing real-time infection control over a computer network. The method comprises obtaining a sample of a microorganism at a health care facility, sequencing a first region of a nucleic acid from the microorganism sample, comparing the first sequenced region with historical... Agent: Bingham Mccutchen LLP

20080206776 - Use of both rd9 and is6110 as nucleic acid targets for the diagnosis of tuberculosis, and provision of multiplex-compliant is6110 and rd9 targets: The present invention relates to the use of both RD9 and IS6110 as nucleic acid targets, for the specific and sensitive detection of a mycobacterium of the Mycobacterium tuberculosis complex (MtbC), and/or for the specific and sensitive discrimination of Mycobacterium tuberculosis and Mycobacterium canetti on one hand, from the other... Agent: Birch Stewart Kolasch & Birch

20080206780 - Antibody libraries: The invention relates to a composition comprising a plurality of antibody fragments, each comprising a framework region having a murine VH14 heavy chain and a murine VK2 light chain, or homologues thereof, each antibody fragment further comprising at least one different CDR.... Agent: Marshall, Gerstein & Borun LLP

20080206781 - Assay and kit for drug efflux transporter activity: The present invention relates to high-throughput cell-based assays for real-time monitoring of multi-resistant drug protein activity. The present invention is an improvement over existing assays in that in addition to a fluorescent drug efflux probe as an indicator of MDR protein activity, the instant assays provide an o-tolidine-based dye for... Agent: Dann, Dorfman, Herrell & Skillman

20080206782 - Methods for determining the bivalency of protein and antibody therapeutics: The invention provides methods and kits for detecting or quantitating intact bivalent antibody molecules in a sample and distinguishing those molecules from monovalent fragments.... Agent: Nikolaos C. George Jones Day

20080206785 - Assays for sensory modulators using a sensory cell specific g-protein alpha subunit: The invention identifies nucleic acid and amino acid sequences of a sensory cell specific G-protein alpha subunit that are specifically expressed in sensory cells, e.g., taste cells, antibodies to such G-protein alpha subunits, methods of detecting such nucleic acids and subunits, and methods of screening for modulators of a sensory... Agent: Townsend And Townsend And Crew, LLP

20080206784 - Target substance-capturing body, device for capturing target substance, and instrument, kit and method for detecting target substance by use of them: It is intended to provide a target substance-capturing body comprising: a base consisting of a soluble protein; and two or more functional domains capable of binding to different target substances.... Agent: Fitzpatrick Cella Harper & Scinto

20080206786 - Trace amine receptor 1 of the african green monkey: A trace amine receptor 1 has been isolated from the genome of Cercopithecus aethiops (African green monkey). Described is the amino acid sequence of the receptor, the nucleic acid encoding the receptor, and methods for using the receptor to identify analytes that are agonists or antagonists of the receptor.... Agent: Merck And Co., Inc

20080206790 - Assay for determining the presence or amount of newly synthesized antibodies: The present invention provides a method of determining the presence or amount of newly synthesised antibody in a sample in response to an immunogen by detecting the released antibodies or parts thereof in a sample containing lymphocytes which have been disrupted whereby to release the synthesised antibodies or parts thereof... Agent: Morgan Lewis & Bockius LLP

20080206789 - Method of screening mhc molecules: The invention relates to a method for screening the binding properties of constituent peptides of MHC molecules by providing in solution MHC molecules or their constituent peptides for a set of MHC molecules including a plurality of subsets of MHC molecules, wherein the MHC molecules of each subset differ from... Agent: Foley And Lardner LLP Suite 500

20080206791 - Method for detecting an unknown contaminant concentration in a substance: A method for determining a concentration of a contaminant in a first sample, the method including producing the first sample, including adding a plurality of immuno-beads to a test substance; exposing a crystal microbalance immunosensor to the first sample; determining a change in a first motional resistance of the crystal... Agent: Michael Best & Friedrich LLP

20080206787 - Process to determine enzyme activity: The present invention provides for various processes for determining enzyme activity. In one embodiment, a process for detecting an enzyme activity includes contacting a blood component with a substrate comprising a cleavage site of the enzyme and a tag moiety to produce a sample comprising a cleavage product having a... Agent: Foley And Lardner LLP Suite 500

20080206792 - Method of identifying compounds useful to treat neuronal degenerative diseases: Methods of identifying agents that inhibit ROS by altering the binding of a GTPase such as Rac to SOD, agents identified by the method, and methods of using compounds that inhibit ROS to inhibit or treat neuronal degenerative diseases, are provided.... Agent: Schwegman, Lundberg & Woessner, P.a.

20080206788 - Reagents and methods for the detection and quantification of vancomycin in biological fluids: t

20080206793 - Ischemic biomarkers and their use to predict adverse neurological events from surgery: Methods are provided for predicting the occurrence of adverse neurological events from surgery. Such adverse events include, for example, stroke, delirium and transient ischemic attach (TIA). The methods are based on the discovery that levels of circulating cerebral NMDA receptor peptides and antibodies can be used to identify patients who... Agent: Clark G. Sullivan Arnall Golden Gregory LLP

20080206795 - Novel supports, in particular for immunodetection of molecules of interest: The invention concerns supports or receptacles for solubilized or suspended biological entities whereof the walls are made of plastics surface-treated by an electromagnetic plasma followed by a polymer deposition. It can be in the form of tubes or multiple-well plates. It provides among other things the possibility of storing, transferring... Agent: Alston & Bird LLP

20080206794 - Systems and methods for characterizing contrast induced-nephropathy: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of contrast-induced nephropathy by detection of cytokines, cytokine-related compounds, and chemokines in urine. The present invention further relates to methods and compositions for assessing the... Agent: Casimir Jones, S.c.

20080206796 - Use of the salivary protein cd14 as an indicator of the low risk to developing dental caries: It is generally accepted that salivary components are important for dental health, but till now no clear correlation has been found between one or more of said components and the onset of dental caries. The present invention relates to an assay method comprising analysing the presence and/or the content of... Agent: Roylance, Abrams, Berdo & Goodman, L.l.p.

20080206797 - Csf diagnostic in vitro method for diagnosis of dementias and neuroinflammatory diseases: CSF diagnostic in vitro method for the diagnosis of dementias and neuroinflammatory diseases, in which a determination of the procalcitonin immunoreactivity (PCT immunoreactivity) is carried out in a sample of cerebrospinal fluid (CSF) of a patient who is suffering from a dementia or neuroinflammatory disease or is suspected of suffering... Agent: Heslin Rothenberg Farley & Mesiti Pc

20080206798 - Kits for detection of atp: Methods and kits for detecting the presence of ATP, for measuring ATP concentrations, and for detecting viable cells using a composition comprising an ATP-dependent enzyme and one or more ATPase inhibitors.... Agent: Indianapolis Office 27879 Brinks Hofer Gilson & Lione

20080206799 - Carbohydrate ratio testing using frequent blood glucose input: An apparatus comprising a user interface configured to generate an electrical signal to begin a carbohydrate ratio test when prompted by a user, an input configured to receive sampled blood glucose data of a patient that is obtained during a specified time duration (including a time duration after delivery of... Agent: Schwegman, Lundberg & Woessner, P.a.

20080206800 - Method for measuring tyrosine kinase phosphorylation: Method, kit and composition for measuring the autophosphorylation of one or more tyrosine kinases in presence of a kinase inhibitor compared to the absence of said kinase inhibitor for kinase specificity profiling of kinase inhibitors.... Agent: Millen, White, Zelano & Branigan, P.c.

20080206804 - Arrangements and methods for multidimensional multiplexed luminescence imaging and diagnosis: Exemplary embodiments of arrangements and methods providing information associated with a sample are described. For example, using such exemplary arrangements and methods, it is possible to receive an unpartitioned electro-magnetic radiation from the sample. Further, first data associated with first luminescent characteristics of at least one first molecule of the... Agent: Dorsey & Whitney LLP Intellectual Property Department

20080206801 - Biological indicator for use with vaporous microbial deactivating agents and method for making same: A biological indicator and method of making same. The biological indicator includes a carrier having a recess formed therein in order to restrict movement of an inoculum deposited onto the carrier. The inoculum includes microorganisms (e.g., bacterial spores) suspended in a suspension medium. The microorganisms are prepared by removing extraneous... Agent: Kusner & Jaffe Highland Place Suite 310

20080206805 - Compounds and related methods for mutant p53 reactivation: Ketoamine compounds and related methods for reactivation of tumor suppressor protein p53.... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator

20080206803 - Metabolic genes and related methods and compositions: Certain aspects of the invention provide nucleic acid constructs that can be used to cause a cell to be dependent on a particular enzymatic activity or on the presence of a particular small molecule. Certain aspects of the invention also provide methods for cloning genes involved in the synthesis, modification... Agent: Ropes & Gray LLP

20080206806 - Method for evaluating or screening hair growth-regulating agent: The present invention is directed to a method for evaluating or screening a hair growth-regulating agent which comprises subjecting hair follicles of a pig to an organ culture in the presence of a test substance, and evaluating or selecting a substance which promotes or suppresses the growth of the hair... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080206802 - Microinjection device and microinjection method: A fluorescence-intensity detecting unit detects fluorescence intensity by injecting a first solution containing a fluorescent reagent into a second solution that does not form an interface with the first solution through an injecting member. A calculating unit calculates the injection amount of the first solution from the fluorescence intensity based... Agent: Staas & Halsey LLP

20080206807 - Methods, reagents, devices and instrumentation for preparing impregnated tissue samples suitable for histopathological and molecular studies: A process for the production of paraffin sections of biological tissue, especially for molecular pathology studies is disclosed. In the process, the tissue sample is simultaneously fixed, dehydrated and cleared in a first step, subsequently dehydrated and cleared in a second step and infiltrated with an inert specimen matrix in... Agent: Knobbe Martens Olson & Bear LLP

20080206808 - Galactosyl nucleotide sugar: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.... Agent: Morgan, Lewis & Bockius LLP (sf)

20080206813 - Means and methods for regulating gene expression: Described are means and methods for regulating gene expression and production of proteinaceous molecules. Described are methods for producing a proteinaceous molecule in a cell comprising selecting a cell for its suitability for producing the proteinaceous molecule, providing a nucleic acid encoding the proteinaceous molecule with a nucleic acid comprising... Agent: Trask Britt

20080206814 - Method for extracellular production of target proteins by co-expression of ompf and target proteins: The present invention relates to a method for secreting and producing a target protein into cell culture broth. More particularly, the invention relates to a microorganism co-transformed with a recombinant expression vector containing E. coli outer membrane protein F (OmpF) and a recombinant expression vector containing a target protein to... Agent: Intellectual Property / Technology Law

20080206812 - Methods for generating high titer helper-free preparations of released recombinant aav vectors: This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector... Agent: Morrison & Foerster LLP

20080206809 - Peptide tags for the expression and purification of bioactive peptides: Peptide tags, referred to here as inclusion body tags, are disclosed and are useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080206815 - Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes, Inc.

20080206811 - Process for producing polypeptide: A process for producing a target protein at low temperature, comprising inducing expression of not only a vector having introduced therein a gene coding for the target protein but also a vector having a chaperone gene introduced therein.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080206810 - Truncated st6galnaci polypeptides and nucleic acids: The present invention features compositions and methods related to truncated mutants of ST6GalNAcI. In particular, the invention features truncated human, mouse, and chicken ST6GalNAcI polypeptides. The invention also features nucleic acids encoding such truncated polypeptides, as well as vectors, host cells, expression systems, and methods of expressing and using such... Agent: Townsend And Townsend And Crew, LLP

20080206816 - Yeast host, transformant and method for producing heterologous proteins: The protease-associated gene is at least one gene selected from the group consisting of psp3 (SPAC1006.01), is sxa2 (SPAC1296.03c), ppp51 (SPAC22G7.01c) and ppp52 (SPBC18A7.01) or at least two genes selected from the group consisting of metalloprotease genes and serine protease genes, especially, three genes psp3 (SPAC1006.01), isp6 (SPAC4A8.04) and ppp53... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080206818 - Process for the fermentative production of antibodies: The present invention relates to a process for producing a correctly folded and assembled full-length antibody using an E. coli strain, which comprises fermenting an E. coli strain which leaks periplasmic proteins into the medium, comprising a gene coding for the heavy chain of an antibody functionally linked to a... Agent: Brooks Kushman P.c.

20080206817 - Rhamnose promoter expression system: The prokaryotic signal sequence is selected from signal peptides of periplasmatic binding proteins for sugars, amino acids, vitamins and ions. The expression of the nucleic acid sequence is controlled by the promoter region. The vector is used for the regulated heterologous expression of a nucleic acid sequence in a prokaryotic... Agent: Fisher, Christen & Sabol

20080206819 - Intensified perfusion production method: The invention comprises a process for producing a protein of interest in a perfusion system using induction agents without a substantial loss of cell viability. The invention also comprises methods of growing cells in a perfusion system using induction agents without a substantial loss of cell viability.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080206820 - Labeling methods with oxygen isotopes: The present invention provides methods for labeling One or two oxygen atom(s) in a carboxyl group of a carboxyl-containing compound with an oxygen isotope selected from oxygen-17 (17O) or oxygen-18 (18O). The methods of the present invention are characterized in that an activated ester of the carboxyl-containing compound (carboxylic acid)... Agent: Birch Stewart Kolasch & Birch

20080206821 - Method for manufacturing xylitol with high-yield and high-productivity: The present invention provides a method for manufacturing xylitol with high-yield and high-productivity by using a xylitol dehydrogenase-deficient mutant of xylitol producing microorganism. This goal is achieved through modification of the metabolic pathway of the xylitol producing microorganism, preferably a natural xylose-assimilating yeasts and fungi, by disrupting or inactivating the... Agent: Fish & Richardson Pc

20080206822 - Method for improving the thermostability of sucrose phosphorylase (sp): A sucrose phosphorylase (SP) having improved thermostability obtained by modifying a natural SP and a method for producing the SP having improved thermostability is provided. This SP having improved thermostability has an amino acid residue which is different from that of the natural sucrose phosphorylase, in at least one position... Agent: Mark D. Saralino (general) Renner, Otto, Boisselle & Sklar, LLP

20080206823 - Method of making a complex: Provided is a method of making at least one inclusion complex comprising a useful complexant and a cyclodextrin, wherein said method comprises the steps of (a) making said cyclodextrin, and (b) mixing said cyclodextrin with said useful complexant, wherein said method is conducted without purifying said cyclodextrin. Also provided is... Agent: Rohm And Haas Company Patent Department

20080206824 - Method for producing optically active alcohols from alkanones using a dehydrogenase of azoarcus: The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocylic or heterocyclic ring, and R1 represents halogen, SH, OH, NO2, NR2R3 or NR2R3R4+X−,... Agent: Connolly Bove Lodge & Hutz, LLP

20080206825 - Method of biosynthesizing tetrodotoxin: The present invention relates methods for the biosynthesis of tetrodotoxin (TTX) involving the steps of obtaining a culture possessing one or more of a Vibrio species, such as through a seed culture, inoculating the culture and tissue extract from a textrodotoxin-bearing organism in a fermenter medium, and isolating and purifying... Agent: Attn: Maquita Wong The Hong Polytechnic University

20080206826 - Method for producing single enantiomer epoxides by the adh reduction of a-leaving group-substituted ketones and cyclization: wherein LG may stand for F, Cl, Br, I, OSO2Ar, OSO2CH3, OSO2R or OP(O)OR2, and R1, R2 and R3, independently of one another, stand for hydrogen, a branched or unbranched, optionally substituted C1-C20-alkyl radical, symbolize an optionally randomly substituted C3-C1-10-cycloalkyl or alkenyl radical or a randomly substituted carbo- or heterocyclic... Agent: Propat, L.l.c.

20080206827 - Method for producing chiral a-hydroxycarboxylic crystalline acids: The invention relates to a method for producing chiral α-hydroxycarboxylic crystalline acids consisting in transforming cyanhydrins (R) or (S) into α-hydroxycarboxylic acids (R) or (S), respectively by enzymatic hydrolysis in the presence of Rhodococcus erythropolis NCIMB 11540.... Agent: Nixon & Vanderhye, Pc

20080206828 - Device for introducing substance into cell, cell clamping device and flow path forming method: A device for introducing a substance into a cell which can realize a high-efficient external substance introduction by means of electro-poration not depending on a cell size, a cell clamping device capable of clamping a cell at many locations, and a flow path forming method capable of efficiently forming a... Agent: Sughrue Mion, Pllc

20080206829 - Epoxy enhanced polymer membrane to increase durability of biosensors: The present invention provides a polymer membrane enhanced with cured epoxy resin for use as the outer membrane of biosensors. The membrane includes approximately 30-80% epoxy resin adhesives, 10-60% polymer such as poly(vinyl chloride), polycarbonate and polyurethane and 0-30% plasticizers and 5-15% surface modifier reagent such as polyethylene oxide-containing block... Agent: Smith Hopen, Pa

20080206830 - Granule with hydrated barrier material: A granule having high stability and low dust is described. The granule includes a hydrated barrier material having moderate or high water activity. Also described are methods of producing the granules.... Agent: Genencor International, Inc. Attention: Legal Department

20080206831 - Substrates useful for cell culture and methods for making and using same: Described herein are substrates coated with crystals having uniform crystalline morphology on the surface of the substrate. The coated substrates are useful in culturing and performing functional assays on cells such as, for example, resorption studies on bone cells. New methods for producing such coated substrates are also disclosed.... Agent: Corning Incorporated

20080206832 - Selection and enrichment of proteins using in vitro compartmentalization: Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a genetic sequence. The selection and enrichment occurs in aqueous droplets formed in an emulsion that compartmentalize individual... Agent: Harriet M. Strimpel, D. Phil.

20080206833 - Mutant glucose dehydrogenase: A mutant glucose dehydrogenase having an improved substrate specificity to glucose, which is a protein comprising the amino acid sequence depicted in SEQ ID NO:3 or an amino acid sequence having the substitution, deletion, insertion or addition of one or more amino acid residues excluding amino acid 365 in the... Agent: Knobbe Martens Olson & Bear LLP

20080206834 - Recombinant organophosphorous acid anhydrase and methods of use: The bacterial gene (opd) encodes an organophosphorus anhydrase which is capable of hydrolyzing a wide spectrum of neurotoxins ranging from insecticides to mammalian neurotoxins. The cloned gene has been expressed in a number of hosts and the purified enzyme has been characterized. These advances have led to a number of... Agent: Daffer Mcdaniel, LLP

20080206835 - Methods and compositions relating to gene silencing: A method for obtaining a mixture of heterogenous short double-stranded RNA molecules suitable for use in gene silencing (hsiRNA) by subjecting large double-stranded RNA to enzymatic cleavage under specified conditions. The resulting mixture consistently includes enhanced representation of fragments having a size of 21-22 nucleotides absent any fractionation step. The... Agent: Harriet M. Strimpel, D. Phil.

20080206836 - Cellulase variants: m

20080206838 - Nanoscaling ordering of hybrid materials using genetically engineered mesoscale virus: The present invention includes methods for producing nanocrystals of semiconductor material that have specific crystallographic features such as phase and alignment by using a self-assembling biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to semi-conductor material. One form of the... Agent: Foley And Lardner LLP Suite 500

20080206837 - Stable adenoviral vectors and methods for propagation thereof: Provided are methods and means to increase the stability and/or the packaging capacity of recombinant adenoviruses, by overexpression of pIX in an adenoviral packaging cell, by retaining at least a part of the E1B-55K region in the recombinant adenoviral vector or by regulating pIX with a heterologous promoter. The invention... Agent: Trask Britt

20080206839 - Use of thermophilic sulphate-reducing archaea for the implementation of a process for the degradation of hydrocarbons: The aim of the invention is to use sulphate-reducing thermophilic archaeobacteria for carrying out a method for degrading linear or branched, saturated or unsaturated, when necessary sulphur, aromatic hydrocarbons under anaerobic conditions.... Agent: Young & Thompson

20080206840 - Cytotoxin-based biological containment: Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and... Agent: Knobbe Martens Olson & Bear LLP

20080206841 - Nucleic acid sequences from chlorella vulgaris and uses thereof: Expressed Sequence Tags (ESTs) isolated from the unicellular green algae, Chlorella vulgaris, are disclosed. The invention encompasses nucleic acid molecules that encode Chlorella protein homologs and fragments thereof. In addition, antibodies capable of binding the proteins are encompassed by the present invention. The disclosed ESTs have particular utility in isolating... Agent: Arnold & Porter, LLP

20080206842 - Method of conversion of biodegradable hygienically non-stabilized substrate into hygienically stabilized product: The pack, made of biodegradable, hygienically non-stabilized, i.e. potentially unhealthy substrate, is placed into a space separated from the surrounding atmosphere and put through aerobic fermentation involving the step of exposing the whole volume of the pack at the same time to the temperature of 70°-80° C. for 30-60 min.... Agent: Oppedahl Patent Law Firm Llc

20080206843 - Compositions and methods for prion decontamination: The invention relates to compositions and methods for prion degradation, decontamination or disinfection. The composition comprises an oxidizing agent, one or more proteases and a surfactant such as an ionic surfactant/detergent. The method comprises contacting a prion contaminated entity with a prion-degrading composition comprising an effective amount of an oxidizing... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080206844 - Method and apparatus for treatment of gases: A method and apparatus for the treatment of contaminated gas which comprises placing a biofilter material (28) into a vessel (10) which is arranged to be sealed. A compressor (14) and valve (16) are provided for feeding pressurised contaminated gas into the vessel (10). A valve (20) is provided for... Agent: Duane Morris, LLP Ip Department

20080206845 - Bioreactor analysis system: A bioreactor analysis system for incubating and analysis of a bioreactive material. The system comprises at least one bioreactor, preferably controlled environment bioreactors. The bioreactor may be held in a sleeve, and multiple sleeves may form a series that moving bioreactors into various storage and interventional positions. At least one... Agent: Gallagher & Dawsey Co., L.p.a.

20080206846 - Thermocycler: A thermocycler is provided that includes a temperature-controlled receiving segment for reaction vials, a top which can be assembled to said base and which in the assembled state may be moved from an open position into an operational position above the receiving segment, an optics configured in the top, where... Agent: Rankin, Hill & Clark LLP

20080206847 - Probe connector assembly and method of use: A probe assembly includes a tubular sleeve having a passage extending between a first end and an opposing second end. The tubular sleeve is movable between an extended position wherein the first end and the opposing second end are spaced apart and a collapsed position wherein the first end and... Agent: Workman Nydegger

20080206849 - Assay device & method: There is disclosed a lateral flow assay device and method of producing the same. The device, which is for identifying carbohydrate antigens in a biological sample comprises a substrate having, a) a sample receiving zone, b) an extraction zone for receiving the sample from said sample receiving zone and which... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080206850 - Methods and compositions for dna synthesis: In some embodiments, the present disclosure relates to new phosphoramidite compositions, that have Silyl-containing carbonate or thiocarbonate or ether as 5′-hydroxyl protecting groups useful of the synthesis of DNA, and in particular for the synthesis of long sequences of DNA (e.g., >50 mer). In some embodiments, there are provided methods... Agent: Agilent Technologies Inc.

20080206851 - Methods and compositions for rna synthesis: In some embodiments, the present disclosure relates to new phosphoramidite compositions, that have Silyl-containing carbonate or thiocarbonate or ether as 5′-hydroxyl protecting groups useful fo the syntheis of RNA, and in particular for the synthesis of long sequences of RNA (e.g., >50 mer). In some embodiments, there are provided methods... Agent: Agilent Technologies Inc.

20080206848 - Nucleic acid analysis device by optical detection using disk: There is provided a method or structure of carrying out optical measurement for the change of the state of the reactive sample solution at two or more measurement points of the channel simultaneously and continuously in a flow system reaction in which the reactive proceeds according to the elapsed time... Agent: Knobbe Martens Olson & Bear LLP

20080206854 - Reactors (medical devices) in which chemical, biochemical, biological reactions - activations take place and their final products are used: Reactors (medical devices), which contains one or more independent of each other solutions and has two or more openings with corresponding indented hollow caps and/or pump and/or needle on the other opening as delivery system. The caps contain within them sensitive or incompatible enzymes, chemical, biological, or synthetic substances in... Agent: Mathews, Shepherd, Mckay, & Bruneau, P.a.

20080206852 - Sample processing apparatus: The present invention provides a sample processing apparatus and a sample container. In a sample processing apparatus, only after a locking member provided on a sample container engages with a sample container receiving portion, the locking member is released. Thereby, a sample fluid is transferred from the sample container to... Agent: Fitzpatrick Cella Harper & Scinto

20080206853 - Signal enhancement system with multiple labeled-moieties: Dipstick tests for detecting analyte are described. In a preferred embodiment, a multiple biotinylated antibody capable of binding analyte is bound to an anti-biotin antibody labeled with colloidal gold and wicked up the dipstick with test solution thought to contain analyte. Complex formed between analyte, biotinylated anti-analyte antibody, and colloidal... Agent: Proskauer Rose LLP

20080206855 - Automated compound screening using gel-permeation matrix and pin-based sample transfer: A system for identifying biological activity of one or more samples using prolonged signaling. The system includes a sample plate, an assay in a permeable media, a test plate, an automated liquid handler and an electronic reader. The sample plate includes one or more individual wells which are used for... Agent: Global Patent Group - Kal Attn: Ms Lavern Hall

20080206856 - Waste converter: A waste converter (10) for domestic use includes two waste conversion regions. Household waste is placed in a primary waste conversion region (40) which includes flies and maggots. When waste has sufficiently decomposed it falls through to a secondary waste conversion region which includes composting worms and woodlice.... Agent: Brooks Kushman P.c.

20080206857 - Device and method for reducing bubble formation in cell culture: A device for minimizing the formation of bubbles or foam in cell culture is disclosed. The device has a manifold which directs the inflow of cells and cell culture media into a cell culture vessel so as to allow for displaced air or gas to vent from the cell culture... Agent: Corning Incorporated

20080206858 - Method and apparatus for producing platelet rich plasma and/or platelet concentrate: Platelet rich plasma and/or platelet concentrate is prepared by placing whole blood in a first chamber of a sterile processing disposable having two chambers. The processing disposable is subjected to a first centrifugation to separate red blood cells, and the resulting platelet rich plasma supernatant is decanted to the second... Agent: Clark & Brody

20080206859 - Live bacteria liquid product applicator: An applicator for applying a liquid carrier having live bacteria suspended therein, which are in a dormant state, to a target host comprising a pump having inlet and discharge sides, with the inlet side of the pump being in fluid communication with the liquid carrier. A first fluid conduit extends... Agent: Thomte Law Office, L.l.c.

20080206863 - Embryonic stem cells capable of differentiating into desired cells lines: An embryonic stem cell which may be induced to differentiate homogeneously into a desired primary cell line. The embryonic stem cell may be engineered with DNA, which encodes a protein or polypeptide which promotes differentiation of the stem cell into a specific cell line, such as, for example, a neuronal... Agent: Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein

20080206862 - High surface cultivation system bag: An exemplary embodiment of a reversibly closable bag suitable for the cultivation of cells and/or tissues can be provided. The exemplary bag can comprise at least one reversibly closable aperture in the bag wall, and a surface-increasing convection arrangement inside the bag. The convection arrangement is capable to generate and/or... Agent: Dorsey & Whitney LLP Intellectual Property Department

20080206860 - Vessel and culture system including: A vessel includes a gas reservoir. The vessel also includes at least one gas outlet. The gas outlet includes an integral gas permeable membrane. A culture system includes the vessel as a first vessel. The first vessel is coupled to a second vessel that includes or otherwise contains a cell,... Agent: Patent Administrator Katten Muchin Rosenman LLP

20080206864 - Methods and materials for culturing murine embryonic stem cells: This disclosure provides methods for culturing murine ES cells in an undifferentiated state using human foreskin fibroblasts (HFF) feeder layer cells in the absence of exogenous Leukemia Inhibitory Factor (LIF).... Agent: Fish & Richardson P.c.

20080206865 - Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells: A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1−/Pax6+ in the presence of FGF2, FGF4, FGF8, FGF 9,... Agent: Quarles & Brady LLP

20080206867 - Fc variants with optimized fc receptor binding properties: The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.... Agent: Morgan, Lewis & Bockius, LLP

20080206866 - Reagency and method for preventing time-dependent expression in biological cells: The present invention relates to a reagent for prevention of time-dependent, induced expression in biological cells in a sample. It likewise relates to a method for this purpose and also to cell preparations treated in this manner, the reagent for prevention of time-dependence induced expression in biological cells in a... Agent: Fulbright & Jaworski L.l.p.

20080206868 - Methods for storing conifer somatic embryo germinants: In one aspect, the present invention provides methods of storing conifer somatic embryo germinants germinated on a sterile germination medium for delayed transplanting into a growth medium. The methods of the invention comprise the steps of: (a) placing the germinants while still on sterile germination medium into a cold environment... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

20080206869 - Nucleic acid complex: The present invention relates to modification of nucleic acids for specific delivery in vitro and in vivo. More specifically, the present invention relates to modification of RNA or DNA molecules in order to add functions in terms of delivery and specificity to RNA interference or antisense technology. A specific binding... Agent: Young & Thompson

20080206870 - Pneumatic capillary gun for ballistic delivery of microscopic particles into tissue: The capillary gun for delivery of ballistic particles to a target includes an inner capillary tube disposed concentrically within an outer capillary tube with the input end of the inner tube connected to a channel through which a continuous flow of high speed helium gas carrying ballistic particles is introduced.... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20080206871 - Large-scale production of recombinant transmembrane and cytosolic proteins: The present invention provides a method for producing large quantities of transmembrane and cytosolic proteins in a mammalian muscle cell. The method involves transfecting skeletal muscle cells in vivo with nucleic acids encoding the proteins by electroporation. The invention results in production of the desired protein on the order of... Agent: Dla Piper Us LLP

20080206872 - Nucleic acid integration in eukaryotes: The invention relates to methods for directing integration of a nucleic acid of interest towards homologous recombination and uses thereof. The present invention discloses factors involved in integration of a nucleic acid by illegitimate recombination which provides a method of directing integration of a nucleic acid of interest to a... Agent: Trask Britt

20080206873 - Complex: A complex comprising a double-stranded DNA containing a terminal repeated sequence originating in a retrovirus and a DNA having a base sequence which does not occur in this retrovirus and a retrovirus-origin protein component.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080199843 - Bioartificial heart tissue graft and method for the production therefor: The invention relates to a method for producing a bioartificial heart tissue graft, which leads to excellent biomechanical properties on the product and guarantees a high cell freedom with optimal preservation of the matrix. During the method, biological cells of a heart tissue preparation, particularly a heart valve or a... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20080199844 - Solution for the storage and perfusion or organs awaiting transplantation: A storage solution to maintain and perfuse organs awaiting transplantation comprising (a) an isotonic balanced solution comprising a physiologically acceptable amount of potassium, mono acidic phosphate, biacidic phosphate, chloride, sodium and bicarbonate ions; (b) 50-250 mM glucose; (c) 0.2-20 mM of an alkanoyl L-carnitine or a physiologically acceptable salt thereof;... Agent: Nixon & Vanderhye, PC

20080199845 - Compositions and methods for prolonging survival of platelets: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to... Agent: Foley & Lardner LLP

20080199846 - Poultry semen extender: A medium for preserving and extending the viable useful life of poultry (e.g., turkey) semen, in vitro, is provided. Semen is preserved without loss of fertility for up to about 24 hours in the medium. The medium contains di-potassium phosphate, sodium glutamate, fructose, sodium acetate, mono-potassium phosphate, potassium citrate, magnesium... Agent: Usda, Ars, Ott

20080199850 - Egfr dependent modulation of chemokine expression and influence on therapy and diagnosis of tumors and side effects thereof: The invention relates to diagnosis and therapy of tumors utilizinging the epidermal growth factor (EGFR) by means of chemical inhibitors or monoclonal antibodies. The invention relates also to skin irritations, preferably skin rash, in conjunction and associated with the treatment of tumor cells that utilize EGF receptor with anti-cancer agents.... Agent: Goodwin Procter LLP Patent Administrator

20080199848 - Method for determining the concentration of asymmetric dimethylarginine (adma): The invention relates to a method for determining the concentration of asymmetric dimethylarginine (ADMA) simultaneously with arginine and with symmetric dimethylarginine (SDMA) in biological samples by means of HPLC-MS-MS. The sample preparation consists exclusively of adding a solution of isotope-labeled internal standards (13C6-argininc and D6-ADMA) and of adding a mixture... Agent: Norris, Mclaughlin & Marcus

20080199847 - Method for predicting the metabolism of drug in human liver and liver function: The invention provides a method for precisely predicting the metabolism of a drug in human liver and the effect of the drug on liver function. The invention provides a method for predicting a metabolite of a test substance produced in human liver and functions of the liver, wherein the method... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080199849 - Method of deriving progenitor cell line: We disclose a method comprising: (a) providing an embryonic stem (ES) cell; and (b) establishing a progenitor cell line from the embryonic stem cell; in which the progenitor cell line is selected based on its ability to self-renew. Preferably, the method selects against somatic cells based on their inability to... Agent: Cohen & Grigsby, P.C.

20080199852 - Detection method for human pappilomavirus (hpv) and its application in cervical cancer: Embodiments of the invention provide methods, assays, and kits for detecting HPV infection and HPV associated epithelial cell abnormalities, most notably those associated with pre-malignant and malignant epithelial cell lesions. Detection of HPV DNAs, genomes, and/or oncoproteins by nucleic acid hybridization assays and immunological assays can be used in early... Agent: Shu-ling Cheng

20080199851 - Methods and compositions for analyte detection: The present invention is directed to methods and apparatus for detection of one or more analytes. Analytes include agents or components of infectious agents such as pathogenic virus, as well as enzymes, proteins and biomarkers.... Agent: Wilson Sonsini Goodrich & Rosati

20080199876 - method of detection of alterations in msh5: We have now discovered that mammals have a DNA gene analogous to that existing in bacteria. MSH5 defects or alterations in this mismatch repair pathway in a mammal, such as a human can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer. We have discovered and... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20080199862 - Active biochip for nucleic acid analysis: Embodiments of the invention relate to an active biochip for nucleic acid analysis. The biochip comprises an inlet for introducing a nucleic acid sample, fluid channels, valves in contact with the fluid channels and pumps in contact with the fluid channels and adapted to generate a carrier gas or move... Agent: Honeywell International Inc.

20080199873 - Companion diagnostic assays for cancer therapy: Methods for identifying cancer patients eligible to receive Bcl-2 family inhibitor therapy and for monitoring patient response to Bcl-2 family inhibitor therapy comprise assessment of the expression levels of the biomarker combinations set out in TABLES 1, 2, 3, 4, 5 or 6 in a patient tissue sample. The methods... Agent: Paul D. Yasger Abbott Laboratories

20080199870 - Compositions and methods for the identification of inhibitors of protein synthesis: Compositions and methods for identifying inhibitors of RNA-target molecule interactions are provided as well as identifying inhibitors that block the role of tRNA in protein synthesis. The methods involve forming a mixture comprising a tRNA fragment molecule containing a modified nucleotide, a target molecule capable of binding to the tRNA... Agent: Hutchison Law Group PLLC

20080199874 - Controllable strand scission of mini circle dna: The invention provides methods and compositions for the controlled termination of polymerase mediated primer extension reactions. The methods and compositions of the invention are broadly useful, and in a preferred aspect can be used in identifying sequence elements of template nucleic acids. Control of termination not only provides temporal control... Agent: Morgan, Lewis & Bockius LLP (sf)

20080199878 - Detection, identification and differentiation of eubacterial taxa using a hybridization assay: The present invention relates to a method for the specific detection and/or identification of Staphylococcus species, in particular Staphylococcus aureus, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between... Agent: Nixon & Vanderhye, PC

20080199855 - Identification and characterization of a subset of glioblastomas sensitive to treatment with imatinib: The present invention relates to methods for in vitro diagnosing a cell proliferative disease in a mammal, for predicting the behaviour of a mammal having a cell proliferative disease in response to a medical treatment using at least one PDGF receptor antagonist, and for selecting a mammal having a cell... Agent: Novartis Corporate Intellectual Property

20080199859 - Identification marker responsive to interferon therapy for renal cell cancer: The present invention provides an identification marker responsive to IFN therapy for renal cell cancer and a means of detecting the same. Namely, a method which comprises preparing a genomic DNA of a human gene or a complementary strand thereof from a specimen of a patient with renal cell cancer,... Agent: Sughrue Mion, PLLC

20080199868 - Massive parallel method for decoding dna and rna: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise... Agent: John P. White Cooper & Dunham LLP

20080199872 - Method and kit for analyzing a target nucleic acid sequence: This invention discloses methods for determining the presence of a target nucleic acid sequence using oligonucleotides that cooperate in a nucleic acid processing reaction to produce a detectable signal. In some embodiments, the methods also facilitate quantification of a target nucleic acid sequence. The present invention further discloses kits that... Agent: Baker & Daniels LLP

20080199858 - Method for detecting estrogen-like chemicals by plant: The present invention is a transformed plant, which is transformed by transducing effector 1 sequence, effector 2 sequence, a target DNA and a reporter gene, wherein said effector 1 sequence has a promoter, a nuclear localization signal, and a chimeric gene comprising a domain coding a polypeptide binding to a... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20080199857 - Method of increasing specificity of nucleic acid hybridization using zwitterionic compound: A method of increasing the specificity of nucleic acid hybridization, comprising hybridizing nucleic acid in a solution containing a zwitterionic compound selected from the group consisting of 3-(cyclohexylamino)-1-propanesulfonic acid (CAPS), 3-[(3-cholamidopropyl)dimethylammonio]-1-propane sulfonate (CHAPS), 3-(cyclohexylamino)-2-hydroxy-1-propane sulfonate (CAPSO), and 2-(cyclohexylamino)ethane sulfonate (CHES) is provided. The method allows a reduction in the yield... Agent: Cantor Colburn, LLP

20080199854 - Methods and compositions for identifying rna-binding proteins: The present invention includes compositions, methods and kits for the identification of a polypeptide that binds to a predetermined RNA sequence. The invention comprises, in part, a photoreactive moiety to aid in identification of such a polypeptide.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20080199864 - Methods for cell screening of compounds capable of modulating the activity of ubiquitin-ligase scf complexes and their uses: The invention concerns methods for cell screening of agents capable of modulating the activity of SCF.sup.Met30 complexes comprising the following steps: (i) contacting the product to be tested with a modified yeast strain, including (a) a hybrid sequence comprising a sequence coding for a Met4 protein, in its wild or... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080199865 - Methods for detecting and treating the early onset of aging-related conditions: Certain aspects of the invention relate to methods for determining a subject's susceptibility to the early onset or progression of aging-related conditions. In certain aspects the invention relates to accessing the genotype of a subject with respect to an allele of IL-1 pattern 1, pattern 2 and/or pattern 3. In... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080199867 - Multiple mode multiplex reaction quenching method: Methods for balancing multiplexed PCR reactions are provided which exploit differences in primer and amplicon Tms. The methods may be controlled by a computer process. Also provided are articles of manufacture useful in such methods and compositions containing primers and probes useful in such methods.... Agent: Jesse A. Hirshman, Esq.

20080199869 - Novel mycobacterium tuberculosis protein composition: Mycobacterium tuberculosis proteins and protein compositions that are components of a desaturase complex are provided. The Mycobacterium tuberculosis desaturase complex may include a desaturase and an oxidoreductase. The complex may include the rv3229c and rv3230c gene products of Mycobacterium tuberculosis. Vectors for expressing the desaturase and the oxidoreductase can be... Agent: Brinks Hofer Gilson & Lione

20080199877 - Oligonucleotide probes for detecting enterobacteriaceae and quinolone-resistant enterobacteriaceae: Oligonucleotide probes for detecting Enterobacteriaceae species. Unique gyrA coding regions permit the development of probes specific for eight different species: Escherichia coli, Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, Klebsiella oxytoca, Klebsiella pneumoniae, Providencia stuartii and Serratia marcescens. The invention thereby provides methods for the species-specific identification of these Enterobacteriaceae in... Agent: Klarquist Sparkman, LLP

20080199856 - Probe for diagnosis of marfan syndrome and a method for screening using the probe: i

20080199863 - Probes and methods for detection of pathogens and antibiotic resistance: Described are probes and methods for detecting pathogens and antibiotic resistance of a specimen. The method comprises contacting the specimen with a growth medium; and lysing the specimen to release nucleic acid molecules from the specimen. The lysate of the specimen is contacted with a capture probe immobilized on a... Agent: Karen S. Canady Canady & Lortz LLP

20080199861 - Real-time microarray apparatus and methods related thereto: Embodiments of the invention relate to a real-time microarray apparatus comprising an upper substrate, a lower substrate, a buffer positioned between the upper and lower substrate, a microarray positioned on either the upper substrate or the lower substrate, a heater positioned near the microarray, a pump positioned near the buffer... Agent: Honeywell International Inc.

20080199866 - Snp detection and other methods for characterizing and treating bipolar disorder and other ailments: The present application relates to the use of SNPs and differential exon expression to characterize, diagnose or treat bipolar disorder and other mental illnesses, such as major depressive disorder and schizophrenia.... Agent: Townsend And Townsend And Crew, LLP

20080199871 - Systems and methods of analyzing nucleic acid polymers and related components: Systems and methods of identifying, sequencing and/or detecting nucleic acid polymers, as well as related components (e.g., substrates, software and the like) are disclosed.... Agent: Wolf Greenfield & Sacks, P.C.

20080199875 - Unsymmetrical cyanine dimer compounds and their application: Embodiments of the present invention provide methods and nucleic acid reporter molecules for the detection of nucleic acid in a sample. The nucleic acid reporter molecule comprises two unsymmetrical cyanine monomer moieties, which may be the same or different, that are covalently attached by a linker comprising at least one... Agent: Invitrogen Corporation C/o Intellevate

20080199860 - Variants of the alpha 1 subunit of human ampk: Variants of the α subunit of AMPK, nucleic acids encoding such variants, and methods for their use are provided.... Agent: Fish & Richardson P.C.

20080199882 - Method for detection of biomarkers for exposure to stachybotrys: A method of determining exposure of an individual to a macrocyclic trichothecene comprises isolating a sample of at least a portion of a naturally occurring protein from an individual, and detecting a reaction of the sample with a macrocyclic trichothecene. The macrocyclic trichothecene may be a product of Stachybotrys, such... Agent: Hahn Loeser & Parks, LLP

20080199879 - Method of assaying alzheimer's disease and diagnostic reagent: It is possible to assay Alzheimer's disease by measuring a total amount of β-amyloid 1-42 and β-amyloid 1-42 fragments each of which retains a C-terminal site of the β-amyloid 1-42 in the biological sample by an immunological assay in which an antibody which recognizes the C-terminal site of β-amyloid 1-42... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080199881 - Mn gene and protein: Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked... Agent: Leona L. Lauder

20080199880 - Spin array method: An improvement in heterogeneous immunoassays to significantly reduce assay time, from as much as 50% up to 90% of what used to be typical assay times. The improvement involves rotating the captured substrate during incubation times for antigen capture and during incubation times for sample labeling.... Agent: Mckee, Voorhees & Sease, P.L.C

20080199884 - Method for measuring protozoan oocyst and detecting reagent: Magnetic fine particles of 5 to 500 nm particle diameter having, immobilized thereto, binding factors for specific recognition of oocyst are added to an analyte containing a protozoan oocyst to form oocyst/binding factor/magnetic fine particle complexes by using a binding reaction to the oocyst, the formed complexes are recovered by... Agent: Greenblum & Bernstein, P.L.C

20080199883 - Schizophrenia related gene and protein: The invention relates to polynucleotides of the PAPAP gene, polypeptides encoded by the PAPAP gene, and antibodies directed specifically against such polypeptides. The invention also concerns methods for the treatment or diagnosis of schizophrenia, bipolar disorder or related CNS disorder. The invention also concerns the interaction of PAPAP with schizophrenia... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080199889 - Human orphan g protein-coupled receptors: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.... Agent: Ropes & Gray LLP

20080199888 - Non-endogenous, constitutively activated versions of human g protein coupled receptor: fshr: The invention disclosed in this patent document relates to transmembrane receptors, particularly to a human G protein-coupled receptor, more particularly to a follicle stimulating hormone receptor (FSHR), and most particularly to mutated (non-endogenous) versions of the human FSHR for evidence of constitutive activity.... Agent: Bozicevic, Field & Francis LLP

20080199890 - Methods of determining cellular chemosensitivity: The present invention provides methods of determining cell sensitivity to a therapeutic agent.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080199891 - Reagents and methods for use in cancer diagnosis, classification and therapy: Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents... Agent: Choate, Hall & Stewart LLP

20080199886 - Igf binding proteins: IGFBP-3 fusion proteins are provided that are useful, for example, in cell-based assays, as IGF antagonists, and in mapping IGF-I and IGF-II binding sites on other molecules such as wild-type IGFBP-3 and IGF agonist peptides identified by phage display. Methods for making such fusion proteins are also provided.... Agent: Heller Ehrman LLP

20080199885 - Overexpression of mammaglobin b in ovarian and endometrial tumors - a new diagnostic and therapeutic marker: The invention involves the discovery that the mammaglobin B gene is the single most overexpressed gene in primary ovarian serous papillary cancer over normal ovarian epithelium among over 14,000 genes tested. It is expressed over 800-fold higher in primary ovarian tumors than normal ovarian epithelium. Mammaglobin B gene expression was... Agent: Hugh Mctavish Mctavish Patent Firm

20080199887 - Compounds and methods for use in detecting gabapentin: Compounds and methods for use in detecting gabapentin in a sample suspected of containing gabapentin are disclosed. Gabapentin derivatives are used to produce gabapentin conjugates. A gabapentin-immunogenic carrier conjugate may be used as an immunogen for the preparation of an anti-gabapentin antibody. A gabapentin-detectable label may be used in a... Agent: Bozicevic, Field & Francis LLP

20080199892 - Process for screening glycoform-specific antibodies: The present invention relates to the use of the assessment of the binding between—antibodies elicited against a first glycoprotein, and—at least one glycoform of a second glycoprotein, said second glycoprotein being itself a glycoform of the first protein, wherein said glycoform of the second glycoprotein is selected from a group... Agent: Nixon & Vanderhye, PC

20080199894 - Device and method for automatic data acquisition and/or detection: Methods and system for providing diabetes management including automatic time acquisition protocol and expiration date detection are provided.... Agent: Jackson & Co., LLP

20080199893 - Medical biosensor by means of which biological liquids are analyzed: Medical biosensor by means of which biological liquids are analyzed, having at least three layers; a functional layer to which a contact adhesive strip, adhesive on both sided, is applied, and a structural film applied to the contact adhesive strip.... Agent: Norris, Mclaughlin & Marcus, P.A.

20080199896 - Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions... Agent: Casimir Jones, S.c.

20080199895 - Highly purified and stabilized na,k-atpase isoforms and methods of producing same: A composition of matter comprising active Na,K-ATPase is disclosed, each Na,K-ATPase comprising an α and β subunit, the Na,K-ATPase being at least 85% purified. Methods of purifying same and uses thereof are also disclosed.... Agent: Martin D. Moynihan Prtsi, Inc.

20080199897 - Class ii histone deacetylase whole cell enzyme assay: The invention relates to enzymatic assays and substrates for Class II histone deacetylases. More particularly, the invention relates to such assays and substrates utilizing whole cells, extracts of such whole cells, extracts of sub-cellular compartments of such whole cells, or bodily fluids.... Agent: Keown & Zucchero, LLP

20080199898 - Compositions for the detection of enzyme activity in biological samples and methods of use thereof: The present invention provides for novel reagents whose fluorescence increases in the presence of particular proteases. The reagents comprise a characteristically folded peptide backbone conjugated to two fluorophores such that the fluorophores are located opposite sides of a cleavage site. When the folded peptide is cleaved, as by digestion with... Agent: Beyer Weaver LLP

20080199902 - Biosensor for determining the biochemical oxygen demand (bod) by respirometry: A removable cartridge that contains an adjustable number of capsules inside of which there are adjustable masses of immobilized microorganisms, allowing the design of a simple, portable apparatus and the use of a reactor with less priming time. A circulating pump injects maintenance water into the reactor, and the used... Agent: Eric Hanscom

20080199900 - Disposable device for one or more introductions, treatment and sampling of biological material from at least one of the separation phases present within the device, under sterility conditions and constant pressure: A disposable device (1) for introduction, treatment and sampling of biological material from at last one of the separation phases under sterility and constant pressure conditions includes a sealed sterile test tube (2), having a first opening (4), or sampling opening, a second opening (7) or inlet opening, and a... Agent: Young & Thompson

20080199899 - Method for screening modulators of mitochondrial functioning and new modulators obtained: The invention relates to a method for screening modulators of mitochondrial function comprising adding a compound to be tested in a purified, isolated mitochondria preparation and simultaneously using fluorimetric analysis of mitochondrial morphology, and especially real-time fluorimetric analysis, combining analysis of morphometric parameters (SSC/FSC parameters) with analysis of membrane integrity... Agent: Nixon & Vanderhye, PC

20080199901 - Method of monitoring microbiological activity in process streams: An apparatus and method for monitoring microbiological activity in a process stream by measuring dissolved oxygen is disclosed. Bulk microbiological activity and surface associated biological activity are measured using this apparatus and method.... Agent: Nalco Company

20080199903 - Biological indicator: A biological indicator for monitoring the effectiveness of a sterilizing, disinfecting, etc., compound or condition is disclosed which comprises a substrate having a surface layer containing functional groups thereon desirably free of silicone linking groups. The functional groups are desirably in the form of a monolayer of a uniformed distribution... Agent: Hudak, Shunk & Farine, Co., L.p.a.

20080199904 - Apparatus and method for detecting and identifying microorganisms: The present invention is an apparatus for detecting the presence, quantity and identity of one or more microorganisms in a sample and a method for using the same. The apparatus is composed of one or more chambers and a sensing element for sensing microorganisms. In particular embodiments, the sensing element... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20080199905 - Catalytic domains of beta(1,4)-galactosyltransferase i having altered metal ion specificity: Disclosed are mutants of galactosyltransferases that can catalyze formation of oligosaccharides in the presence of magnesium; mutants of galactosyltransferases having altered donor and acceptor specificity which can catalyze formation of oligosaccharides in the presence of magnesium; methods and compositions that can be used to synthesize oligosaccharides; methods for increasing the... Agent: Edwards Angell Palmer & Dodge LLP (client Reference No. 47992)

20080199907 - Method for preparing a target protein using the shsps: The present invention relates to a method for separating and purifying a target protein, a method for preparing a target protein, and a method for bioconversion by a whole cell enzyme or a partially purified enzyme. According to the present invention, when the sHSPs are added in cultivation, separation and... Agent: Intellectual Property / Technology Law

20080199906 - Optimized nucleotide sequences encoding sgp 130: Described are codon optimized sgp130 encoding nucleic acid molecules as well as a method for the highly efficient recombinant production of sgp130 in mammalian cells or bacteria using a nucleic acid molecule of the invention.... Agent: Wilson Sonsini Goodrich & Rosati

20080199908 - Production of cellulase: The invention relates to a process of producing cellulase in a host cell, comprising cultivating said host cell capable of producing cellulase under conditions conducive for production of cellulase, wherein pre-treated ligno-cellulosic material is added to induce cellulase production. The invention also relates to use of pre-treated ligno-cellulosic material as... Agent: Novozymes North America, Inc.

20080199909 - Methods for expression and purification of recombinant human growth hormone: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080199912 - Methods for obtaining optically active epoxides and diols from 2,3-disubstituted and 2,3-trisubstituted epoxides: The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific internal epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vectors containing such nucleic acid molecules, and cells containing such vectors. Also embraced by the invention are methods for... Agent: Fish & Richardson P.C.

20080199913 - Production of recombinant il-18 binding protein: The invention relates to a process for the production of IL-18 binding protein (IL-18BP), and to a composition comprising IL-18BP characterized by a specific glycosylation pattern.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080199910 - Production of recombinant insulin-like growth factor-i (igf-i) and insulin-like growth factor binding protein-3 (igfbp-3) in transgenic monocots: Two important human proteins, insulin growth factor I (IGF-I) and insulin growth factor binding protein 3 (IGFBP-3) have been produced in monocots. The recombinantly produced proteins exhibit the known activities of the native forms.... Agent: Morrison & Foerster LLP

20080199911 - Vp1 of foot-and-mouth disease virus: A pure, water-soluble polypeptide containing one or more monomers of a VP1 protein of a foot-and-mouth disease virus; or a pure, water-insoluble polypeptide comprising two or more monomers of a VP1 protein of a foot-and-mouth disease virus. Also disclosed are a vaccine containing the polypeptide, a method of producing the... Agent: Occhiuti Rohlicek & Tsao, LLP

20080199914 - Modified alginates, methods of production and use: Process for preparing a modified alginate polymers are disclosed. The processes comprise the steps of covalently attaching a modifying moiety to one or more unmodified monomeric subunits of an alginate polymer; and changing one or more unmodified mannuronic (M) monomeric subunits of the alginate polymer to one or more unmodified... Agent: Patent Administrator Fmc Corporation

20080199915 - Methods and kits for mass production of dsrna: The invention relates to methods and kits for propagating target nucleic acid in the form of double stranded RNA. This invention relates in particular to a method for mass production of dsRNA. The method comprises that a target nucleic acid is provided in a form replicable by an RNA-dependent RNA... Agent: Foley And Lardner LLP Suite 500

20080199916 - Multiplex targeted amplification using flap nuclease: Methods for multiplex amplification of a plurality of targets of distinct sequence from a complex mixture are disclosed. In one aspect targets are circularized using a single circularization probe that is complementary to two regions in the target that flank a region to be amplified. The targets may hybridize to... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20080199917 - Means and methods for producing adenovirus vectors: The invention relates to methods and means for producing adenoviral vectors on complementing cell lines, wherein the early region 4 open reading frame 6 (E4-orf6) encoding nucleic acid is present in the adenoviral vector and wherein the E4-orf6 gene product is compatible with one or more products of the E1... Agent: Trask Britt

20080199853 - Methods and compositions for diagnosis and monitoring auto immune and chronic inflammatory diseases: Methods of diagnosing or monitoring auto immune and chronic inflammatory diseases, particularly systemic lupus erythematosis and rheumatoid arthritis, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring auto immune and chronic inflammatory diseases, particularly systemic... Agent: Morrison & Foerster LLP

20080199918 - Starch process: The present invention relates to a process for enzymatic hydrolysis of granular starch into a soluble starch hydrolysate at a temperature below the initial gelatinization temperature of said granular starch... Agent: Novozymes North America, Inc.

20080199919 - Method for producing l-lysine or l-arginine by using methanol assimilating bacterium: A DNA encoding a variant of a protein having a loop region and six hydrophobic helixes which is involved in excretion of L-lysine to outside of a cell is described, wherein the DNA encodes a mutant protein which does not contain the loop region that is present in the wild-type... Agent: Cermak & Kenealy LLP Acs LLC

20080199920 - S-adenosylmethionine-6-n-lysine-methyltransferase from neurospora crassa, a gene encoding the same, a vector and host cell containing the same, and method for producing trimethyllysine using the host cell: Provided is S-adenosylmethionine-6-N-lysine-methyl-transferase obtained from Neνrospora crassa, a polynucleotide encoding the same, a vector and host cell containing the polynucleotide, and a method of producing trimethyllysine by culturing the host cell.... Agent: Cantor Colburn, LLP

20080199921 - Process for producing glutamate derivatives: The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080199922 - Chemoenzymatic process for the synthesis of escitalopram: A process is described for the preparation of escitalopram and the pharmaceutically acceptable salts thereof starting from 5-cyanophthalide by a process which provides an enantioselective enzymatic deacylation reaction of a complex of the formula (IV) where R represents a C1-C4 alkyl residue or an aryl residue under the action of... Agent: Perkins Coie LLP

20080199923 - Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids: Disclosed is a process for growing the microflora Thraustochytrium, Schizochytrium, and mixtures thereof, which includes the growing of the microflora in fermentation medium containing non-chloride containing sodium salts, in particular sodium sulfate. In a preferred embodiment of the present invention, the process produces microflora having a cell aggregate size useful... Agent: Sheridan Ross P.C.

20080199925 - Method for producing an aqueous polymer dispersion: A process for preparing an aqueous polymer dispersion, in which, in an aqueous medium, in a first reaction stage, a hydroxycarboxylic acid compound is reacted in the presence of an enzyme and of a dispersant, and also, if appropriate, of a low water solubility organic solvent and/or of an ethylenically... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080199924 - Production of degummed fatty acid alkyl esters: The present invention relates to a method for producing fatty acid alkyl esters, such as fatty acid methyl esters (FAME) and fatty acid ethyl esters with a low level of impurities such as phospholipids. The method of the invention is simplified by combining two process steps into one single process... Agent: Novozymes North America, Inc.

20080199926 - Methods and organisms for growth-coupled production of 3-hydroxypropionic acid: The invention provides a non-naturally occurring microorganism having one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory coupling 3-hydroxypropionic acid production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby the one or more... Agent: Mcdermott, Will & Emery

20080199927 - Aspergillus kawachi acid-stable alpha amylase and applications in granular starch hydrolysis: The present invention relates to a method for producing an end product and particularly an alcohol which comprises contacting a granular starch substrate with an acid-stable alpha amylase (asAA) having granular starch hydrolyzing (GSH) activity and a glucoamylase (GA) in a fermentation step which also comprises ethanologenic microorganisms at a... Agent: Lynn Marcus-wyner Genencor International

20080199928 - Producing hydrogen by heterologous expression of a type ii nad (p)h deshydrogenase in chlamydomonas: The invention concerns the use of a type II NAD(P)H dehydrogenase (NDH-II), or of a polynucleotide encoding said NDH-II, to increase the capacity of a green algae to produce hydrogen. Said polynucleotide is in particular useful for transforming said green algae, so as to improve its hydrogen production.... Agent: Alston & Bird LLP

20080199930 - Method and apparatus for the rapid disruption of cells or viruses using micro beads and laser: A method and apparatus for rapid disruption of cells or viruses using beads and a laser are provided. According to the method and apparatus for rapid disruption of cells or viruses using beads and a laser, cell lysis within 40 seconds is possible, the apparatus can be miniaturized using a... Agent: Cantor Colburn, LLP

20080199929 - Method and system for collecting cells following laser microdissection: A method of collecting target regions from a target object is described. The method in one embodiment comprises mounting a negatively-charged membrane on a first side of a substrate, mounting a target object on the membrane, positioning a collection material adjacent to the target object, and passing a laser beam... Agent: Trexler, Bushnell, Giangiorgi, Blackstone & Marr, Ltd.

20080199931 - Polynucleotide encoding an intracellular estradiol binding protein: Described herein is a novel intracellular estradiol binding protein (“IEBP”), as well as a polynucleotide encoding this protein and various cells and cell lines producing and/or overexpressing it. IEBP is believed to play a role in the modulation of estrogen signaling and in the physiological resistance to the same. Abnormally... Agent: Davis Wright Tremaine LLP/los Angeles

20080199932 - Active surface coupled polymerases: Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.... Agent: Quine Intellectual Property Law Group, P.C.

20080199933 - Amine oxidase inhibitors: A therapeutic agent for selectively inhibiting amine oxidases associated diseases and conditions in humans includes at least one compound selected from the group consisting of propargylamines, polypropargylamines, homopropargylamines, 4-substituted-2-butynylamines, 2- and 3-halloallylamines, pyrroline derivatives, cycloalkenyl branched primary amines, propargyl diamines, homopropargyl amines and diamines, allenyl amines and diamines, chloroallyl diamines,... Agent: Tarolli, Sundheim, Covell & Tummino, LLP

20080199934 - Functional peptide fiber, production method thereof and method for recovering peptide chains: This invention provides a functional peptide fiber which comprises a plurality of peptide structure units each containing at least one peptide chain, wherein peptide chains contained in each adjacent peptide structure units do not form peptide bond but are structured into a fibrous form by taking a β-sheet structure, and... Agent: Oliff & Berridge, PLC

20080199935 - Compositions and methods utilizing dna polymerases: The invention features a novel isolated Family B DNA polymerase, a Thermococcus polymerase JDF-3, and mutant recombinant forms thereof. Mutant polymerases of the invention are deficient in 3′ to 5′ exonuclease activity and/or exhibit reduced discrimination against non-conventional nucleotides relative to the wild-type form of the polymerase.... Agent: Agilent Techologies Inc

20080199936 - Fen endonucleases: The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a... Agent: Casimir Jones, S.c.

20080199937 - Reagent composition and methods of using and forming the same: A reagent composition containing GDH-PQQ as an enzyme-co-factor and screen-printed on working and counter electrodes of electrochemical biosensors, maintains activity of the enzyme reagents by proper selection of components. A preferred composition includes hydrophilic polymers, amorphous untreated silica, buffers, surfactants, and a mediator For example, the biosensor is useful in... Agent: Nixon Peabody LLP

20080199938 - Novel cellulase resistant to surfactant: Disclosed is a novel cellulose having an amino acid sequence in which the 162nd and/or 166th amino acid residues in the amino acid sequence of cellulose NCE5 are substituted. Further, a polynucleotide encoding the novel cellulose, an expression vector containing the polynucleotide, a host cell transformed with the expression vector,... Agent: Sughrue Mion, PLLC

20080199939 - Adenoviral vectors and uses thereof: The present invention relates to recombinant adenoviral vectors based on adenoviruses that encounter pre-existing immunity in a minority of the human population and which harbour a chimeric capsid. The chimeric capsid comprises fiber proteins that have at least the knob domain of a human adenovirus that binds to the Coxsackievirus... Agent: Trask Britt

20080199940 - Farnesyl dibenzodiazepinone and processes for its production: This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in... Agent: Merchant & Gould PC

20080199941 - Fusobacterium polypeptides and methods of use: The present invention provides isolated polypeptides isolatable from a Fusobacterium spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.... Agent: Mueting, Raasch & Gebhardt, P.A.

20080199942 - Method of engineering a cytidine monophosphate-sialic acid synthetic pathway in fungi and yeast: The present invention provides methods for generating CMP-sialic acid in a non-human host which lacks endogenous CMP-Sialic by providing the host with enzymes involved in CMP-sialic acid synthesis from a bacterial, mammalian or hybrid CMP-sialic acid biosynthetic pathway. Novel fungal hosts expressing a CMP-sialic acid biosynthetic pathway for the production... Agent: Merck And Co., Inc

20080199943 - Material solubiliser reactor for hydrolysis and/or wet fermentation and waste treatment plant with such a solubiliser and reactor: The invention relates to a method for the treatment of waste with organic components, whereby in standardized method steps, various material solubilisers, for dissolving the organic material in a solvent and various reactors for carrying out a hydrolysis and/or a wet fermentation are used depending on the particle size and... Agent: Boyle Fredrickson S.c.

20080199944 - Pressure controllable incubation system: A pressure controllable incubation system is provided for constantly maintaining a concentration of carbon dioxide while keeping a pressure chamber, in which living organisms to be cultured are placed, at a pressure higher than atmospheric pressure. The pressure controllable incubation system comprise a bomb that stores air containing high-concentration carbon... Agent: Casimir Jones, S.c.

20080199945 - Cantilever for measuring intra-cellular and inter-cellular microspaces: A cantilever for measuring intra-cellular and inter-cellular microspaces of the present invention includes a support portion, a lever portion provided to the support portion so as to protrude therefrom, and a probe portion provided near a free end of the lever portion. The probe portion includes a conductive probe made... Agent: Scully Scott Murphy & Presser, PC

20080199946 - Biochip: The present invention relates to a biochip for nucleic acid hybridization. The biochip of the present invention comprises a hybridization chamber which is in the form of a cavity, a porous matrix pressed in the hybridization chamber; and at least one first circulation hole and at least one second circulation... Agent: Lin & Associates Intellectual Property, Inc.

20080199947 - Blood cell analyzer, blood cell analyzing method, and computer program product: A blood cell analyzer is provided with a first detection unit for electrically detecting blood cells in blood sample; a second detection unit for optically detecting blood cells in blood sample; a volume information obtainer for obtaining volume information of red blood cells based on the electrically detected blood cells;... Agent: Brinks Hofer Gilson & Lione

20080199949 - Device for sampling blood droplets under vacuum conditions: A blood extraction device (100) and method for withdrawing a controlled number of drops of blood from a patient, in whom there is created an incision of such dimension that blood does not freely flow therefrom. A release unit (160) urges drops of blood to flow from the incision, for... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080199948 - System for detecting infectious agents using computer-controlled automated image analysis: A method for recognizing an object in an image is disclosed wherein a fractal map of the image is generated by estimating the fractal dimension of each pixel in the image. The fractal map may be segmented by thresholding and locations of candidate objects are determined. The pixel value of... Agent: Kelley Drye & Warren LLP

20080199950 - Enhanced bio-assays by using gradient nanotopgraphy: ABSTRACT A system and method for using gradient nanotopography to increase mammalian cell attachment and cell confinement on surfaces. A surface platform consisting of a thin film of gold possessing a gradient of topography on the surface and self-assembled monolayers of alkanethiols presenting desired functional groups is formed. A gradient... Agent: Bond, Schoeneck & King, PLLC

20080199951 - Device for the storage and treatment of biodegradable wet solid waste: The present invention relates to a device for the storage and treatment of biodegradable wet solid waste, especially for vegetarian household waste materials. The device consists of a bucket shaped container with a mesh bottom and a removable cover with a hole at the center. The container is provided with... Agent: Greenlee Winner And Sullivan P C

20080199952 - Compositions and methods for treating or preventing pneumococcal infection: The invention provides polypeptides, polysaccharide-polypeptide conjugates, and expression vectors for treating or preventing pneumococcal infection. The compositions induce an anti-pneumococcal immune response when administered to a mammal. The compositions can be used prophylactically to vaccinate an individual and/or therapeutically to induce a therapeutic immune response in an infected individual.... Agent: Occhiuti Rohlicek & Tsao, LLP

20080199954 - Methods for sorting dimorphic daughter cells: This invention relates to methods for distinguishing and sorting cells. In particular it includes methods for distinguishing and sorting post-mitotic and post-meiotic daughter cells into two classes according to differential cellular features. Labeling, tagging, or marking of the cells' chromatin proteins, RNA, or DNA may assist in distinguishing the daughter... Agent: Kirton And Mcconkie

20080199953 - System and method for forming a connective tissue construct: A system and method are provided for forming a connective tissue construct, such as a tendon construct, in vitro. A substrate is provided with at least two anchors secured thereto in spaced relationship. Fibroblast cells are provided on the substrate in the absence of a synthetic matrix, where at least... Agent: Brooks Kushman P.C.

20080199955 - Tissue infiltration apparatus: A tissue infiltration apparatus (1) for specimens present in cassettes (5). comprises at least two liquid containers (7, 11, 13, 15) and a transport apparatus (6). A liquid having a definable property is introducible into a liquid container (7, 11, 13, 15). Multiple cassettes (5) are receivable in a transport... Agent: Hodgson Russ LLP The Guaranty Building

20080199956 - Storage medium for cells: The invention relates to a method for storages of human cells in particular, cell media for storage of cells and the use of such cell media for storage of cells, wherein the vitality of the cells is preserved during the storage.... Agent: Darby & Darby P.C.

20080199957 - Enhanced transport using membrane disruptive agents: Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20080199958 - Suspension culture vessels: A cell culture vessel comprising a housing chamber which has an inverted frusto-conical bottom having a vertical axis. The culture vessel further comprises an upper and lower section which are concentric. The vessel requires little or no shear-force and less stress by shaking or impellor action.... Agent: Occhiuti Rohlicek & Tsao, LLP

20080199959 - Method for cell culture: The present invention relates to a method for cell culture, more precisely small scale cell culture. In the present invention a screening tool is used which comprises particulate matter or microcarriers, such as beads, attached to a solid support, such as a microtiter plate, for the cultivation of cells on... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20080199960 - Methods for the delivery of oligomeric compounds: The presently disclosed subject matter relates to the delivery of oligonucleotides to cells through the delivery of a composition or reagent comprising a hybridization complex comprising a first antisense oligonucleotide which is modified to have a higher stability against degradation, and a second sense oligonucleotide which is prone to degradation.... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20080199961 - Antisense composition and method for inhibition of mirna biogenesis: The present disclosure relates to compounds and methods for inhibiting the formation of miRNAs that inhibit translation of one or more identified proteins. The compounds comprise antisense oligonucleotides targeting the pri-miRNA precursor of miRNAs.... Agent: Perkins Coie LLP

20080193910 - System and method for forming skeletal muscle constructs having functional tissue interfaces: A system and method for forming a skeletal muscle construct include primary muscle cells provided on a substrate without disposing the cells within an exogenous scaffold, the cells cultured in vitro such that the cells form a confluent monolayer; at least two anchors secured to the monolayer in spaced relationship;... Agent: Brooks Kushman P.c.

20080193911 - Sulfide perfusion: An apparatus for establishing sulfide perfusion is described and includes a sulfide supply for introducing sulfide into fluid for perfusion, an apparatus for delivery of the perfusion fluid, a fluid chemistry monitor for monitoring the concentration of sulfide and other components of the perfusion fluid, and an electronic controller connected... Agent: Tomas Friend, Llc

20080193912 - Compositions and methods for preparation of nucleic acids from microbial samples: Methods and compositions for releasing the nucleic acids from a variety of different types of microorganisms are provided. The method relies on a simplified lysis procedure that can be applied to many types of bacteria and fungal cells and is readily automated for high throughput screening methods. The method utilizes... Agent: Novartis Vaccines And Diagnostics Inc.

20080193913 - Diluent, methods of manufacture and use: The use of diluent to reduce non-specific drug binding (NSB) provides a simple, flexible and biocompatible way to reduce chemical entity (such as drugs, drug candidates and other small molecules) NSB so that bioassay results may more closely predict the behavior of these compounds in vitro. Additionally, the use of... Agent: Millipore Corporation

20080193914 - Biomarker derivation method: A method for deriving a quantitative value for a specific biomarker of an individual includes providing a set of biomarkers from a blood sample of the individual, the set of biomarkers not including the specific biomarker. Adjusted marker values for biomarkers not present in the set of biomarkers are provided.... Agent: Robert A. Parsons

20080193917 - Biological detection system and method: The present disclosure provides a biological detection system and method. One detection system may include a genetically engineered phage that expresses a surface molecule able to bind a target molecule; a bacterium susceptible to infection by the phage; and a detection component able to determine whether the bacterium has been... Agent: Baker Botts L.l.p. Patent Department

20080193918 - Compositions and methods for monosynaptic transport: Disclosed herein are methods of expressing a heterologous nucleic acid sequence, such as a sequence encoding a detectable protein, in a primary neuron (or plurality of primary neurons) and other neurons that are monosynaptically connected to the primary neuron (or plurality of primary neurons). Such methods involve viruses (such as,... Agent: Klarquist Sparkman, LLP

20080193915 - Isotope labeled dinitrophenylhydrazines and methods of use: The subject invention provides novel isotope-labeled dinitrophenylhydrazines (DNPHs) and methods for their use in detecting and/or quantifying carbonyl groups in proteins and other analytes. In particular, the present invention provides novel methods for identifying biomarkers of oxidative stress, which can be used to either forecast or detect diseases and/or conditions... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080193916 - Method of detecting hepatitis b virus s antigen: e

20080193920 - Methods and systems for producing recombinant viral antigens: The present invention relates to recombinant expression vectors which express segments of deoxyribonucleic acid that encode recombinant HIV and HCV antigens. These recombinant expression vectors are transformed into host cells and used in a method to express large quantities of these antigens. The invention also provides compositions containing certain of... Agent: Joseph E. Mueth, Esq.

20080193921 - Methods to identify agents that bind the flap-tip helix of rna polymerase: The invention provides methods to identify moieties which specifically bind the flap-tip helix of the β subunit of RNA polymerase and to identify inhibitors of the interaction between those moieties and the flap-tip helix.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.a.

20080193919 - Systems and methods for receiving pathogen related information and responding: The present disclosure relates to methods and systems that may be used for detection of one or more pathogens and determining one or more agents in response to pathogen detection.... Agent: Searete Llc Clarence T. Tegreene

20080193924 - Cardiovascular safety assay: The present invention provides assays and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. Said assays and kits are based on the finding that the interaction of astemizole with the HERG potassium channel can be exploited to predict cardiotoxicity of compounds during... Agent: Philip S. Johnson Johnson & Johnson

20080193943 - Companion diagnostic assays for cancer therapy: A method for classifying cancer patients as eligible to receive cancer therapy with a small molecule inhibitor of Bcl-2 comprising determination of the presence or absence in a patient tissue sample of chromosomal copy number status at the chromosomal locus 13q14 comprising the microRNA's miR-15a and miR-16-1 or at the... Agent: Vysis, Inc Patent Department

20080193939 - Corneodesmosin based test and model for inflammatory disease: The present invention relates to a polynucleotide encoding the corneodesmosin protein having one or more nucleotide insertions, deletions, or substitutions at one or more novel positions. The invention also relates to the corneodesmosin protein having one or more amino acid insertions, deletions, and substitutions. These nucleotide and amino acid polymorphisms... Agent: Christensen, O'connor, Johnson, Kindness, Pllc

20080193935 - Detection of dna sequence motifs in ruminants: A method for detecting a repeat element in a target ruminant nucleic acid sequence, the method comprising the steps of: (a) contacting a nucleic acid probe capable of hybridizing with a nucleotide sequence flanking said element; and (b) detecting the complex formed between the probe and the target nucleic acid... Agent: Davidson, Davidson & Kappel, Llc

20080193926 - Device and method for extracting a smear sample: A device is disclosed for extracting a smear sample. The device includes a cavity, into which a sample carrier carrying a smear sample can be introduced. Liquid can be introduced into the cavity through at least one liquid feed connected to the cavity, and the liquid can be removed from... Agent: Harness, Dickey & Pierce, P.L.C

20080193923 - Human obesity susceptibility gene encoding a potassium voltage-gated channel and uses thereof: The present invention discloses the identification of a human obesity susceptibility gene, which can be used for the diagnosis, prevention and treatment of obesity and related disorders, as well as for the screening of therapeutically active drugs. The invention more specifically discloses that the KCNAB2 gene on chromosome 1 and... Agent: Occhiuti Rohlicek & Tsao, LLP

20080193937 - Identification of a sterol acyltransferase gene: The present invention relates to the use of genetic engineering to produce sterol esters. In one embodiment, an isolated or recombinant nucleic acid molecule encoding a sterol acyltransferase is disclosed. In another embodiment, a cell transformed with the isolated or recombinant nucleic acid molecule encoding a sterol acyltransferase is disclosed.... Agent: Ade & Company Inc.

20080193938 - Materials and methods relating to breast cancer classification: The invention provides materials and methods for classifying breast cancer in patients. Particularly there is provided a novel gene expression signature which acts as a predictive signature for response to treatment including hormonal therapies (e.g. tamoxifen) and chemotherapy.... Agent: Dann, Dorfman, Herrell & Skillman

20080193945 - Method and kit for the diagnosis of ulcerative colitis: The differentiation between ulcerative colitis and Crohn's disease is made possible by a multi-gene approach where gene expression profiles in biopsy samples obtained from inflamed, and optionally also non-inflamed, areas in the intestines of a patient are studied.... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper Us LLP

20080193927 - Method for determining the abundance of sequences in a sample: The invention relates to a method for determining the abundance of a given sequence or several sequences identical or nearly identical to the given sequence in a sample. The method comprises the following steps: carrying out one or more amplification reactions by means of which several different sections of the... Agent: Dilworth & Barrese, LLP

20080193933 - Method of generating transgenic organisms using transposons: The invention relates to a method for generating a transgenic organism. The invention also relates to a method for detecting and characterizing a genetic mutation in a transgenic organism. The invention further relates to a method for isolating a gene which is correlated with a phenotypic characteristic in a transgenic... Agent: Edwards Angell Palmer & Dodge LLP

20080193931 - Method of rapidly quantifying global dna methylation: This invention is related to a method and assay kit for rapidly quantifying global DNA methylation through immobilizing DNA by simple dry-capture on the plastic carrier followed by immunodetection of 5-methylcytosine structure that is the marker of DNA methylation.... Agent: Weiwei Li

20080193922 - Methods and compositions for inferring eye color and hair color: Methods for inferring eye color or eye shade of an individual from a nucleic acid sample of the individual by detecting the nucleotide occurrence of an eye color related single nucleotide polymorphism (SNP) as set forth in SEQ ID NOS: 1 to 7 and, optionally, SEQ NOS:8 to 10 and/or... Agent: Dla Piper Us LLP

20080193928 - Methods and compositions for modulating apoptosis: Provided are compositions and methods useful for treating and diagnosing cell proliferative disorders associated with Hsp90 and/or ZAP-70.... Agent: Buchanan, Ingersoll & Rooney LLP

20080193929 - Methods and systems for identifying and isolating stem cells and for observing mitochondrial structure and distribution in living cells: Methods and systems for a) identifying and isolating stem cells, b) assessing mitochondrial distribution and structure in living cells and c) performing fluorescence microscopy on living cells while the cells remain within a condition-controlled cell culture chamber.... Agent: Stout, Uxa, Buyan & Mullins LLP

20080193932 - Methods of inhibiting the activity of hsp90 and/or aryl hydrocarbon receptor: The present invention relates to a method of screening compounds for binding to hsp90 by exposing a compound to hsp90 or a polypeptide fragment thereof containing amino acid residues 538-728 of the full length protein and determining whether the compound binds to hsp90 of the polypeptide fragment thereof. Also disclosed... Agent: Nixon Peabody LLP - Patent Group

20080193944 - Novel cark protein and nucleic acid molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated CARK nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CARK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a CARK gene has been introduced... Agent: Millennium Pharmaceuticals, Inc.

20080193941 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of cardiac disease: Novel markers for cardiac disease that are both sensitive and accurate. These markers are differentially and/or specifically expressed in cardiac tissue, as opposed to other types of tissues, optionally and preferably including muscle tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the... Agent: Staas & Halsey LLP

20080193936 - Polymorphism detection method: A method for detecting the presence or absence of a polymorphism at a particular position within a nucleic acid sequence in a sample, said method comprising i) annealing a pair of probes to said nucleic acid sequence, said probes being designed such that they anneal adjacent each other, and only... Agent: Polsinelli Shalton Flanigan Suelthaus Pc

20080193930 - Quantitation of cellular dna and cell numbers using element labeling: Methods and kits for the quantitation of cellular DNA and cell numbers are provided. Passive element uptake, element-labeled DNA intercalators, and element labeled affinity reagents are used to quantify DNA and cells. The DNA and the cells are analyzed by elemental analysis, including ICP-MS. The methods and kits provide a... Agent: Torys LLP

20080193934 - Specialized oligonucleotides and their use in nucleic acid amplification and detection: Described herein are labeled probes and unlabeled oligonucleotides that are useful for use in nucleic acid amplification reactions. These probes and oligonucleotides are modified to alter their sensitivity to primer-independent 5′ exonuclease activity of a thermostable DNA polymerase relative to its corresponding unmodified counterpart. Non-symmetric polymerase chain reaction (PCR) amplification... Agent: Foley And Lardner LLP Suite 500

20080193942 - System and method for identifying erythropoietin-responsive genes: The present invention relates to the generation of a population of Epo-responsive marrow derived cells that express Epo-responsive genes and gene products. The present invention also relates to the detection of Epo-responsive genes and gene products as well as to the detection of the administration of Epo, Epo-derivatives and Epo-mimetics... Agent: Kevin M. Farrell Pierce Atwood

20080193940 - Systems and methods for detecting nucleic acids: A method and kit for detecting a target nucleic acid in a sample is described. The sample to be analyzed may include a primer which hybridizes to at least a portion of the target nucleic acid, a probe having a first region which hybridizes to at least a portion of... Agent: Morris Manning Martin LLP

20080193925 - Thermostable y-family polymerases and chimeras: The present disclosure is related to thermostable Y-family polymerases, in particular several novel Y-family polymerases and chimeras made therefrom, as well as methods of identifying other Y-family polymerases, methods of generating other chimeric Y-family polymerases, methods of amplifying ancient or damaged DNA, and methods of incorporating fluorescent or modified nucleotides... Agent: Klarquist Sparkman, LLP

20080193946 - Universal and target specific reagent beads for nucleic acid amplification: The present invention relates to methods and compositions providing optimized reaction conditions for nucleic acid amplification reactions and for methods and compositions that reduce contamination of amplification reactions during set up.... Agent: Townsend And Townsend And Crew, LLP

20080193947 - Complementary peptides for beta-amyloid 29-42 peptide: The invention relates to peptides derived from the wild type ApolipoproteinE3 peptidic fragment 270-287 (ApoE WT) of sequence EDMQRQWAGLVEKVQAAV (SEQ ID NO: 2), having improved interaction with the β-Amyloid peptidic fragment 29-42 (Aβ 29-42) GAIIGLMVGGVVIA (SEQ ID NO: 1), in a [Aβ 29-42/ApoE mutant n] complex.... Agent: Knobbe Martens Olson & Bear LLP

20080193948 - Identification and screening of triptolide target molecules: The identification of triptolide target molecules is described. Also described are methods of screening triptolide-related compounds for binding to these molecules, including screening for enhanced and/or selective binding, and expression analysis of the target molecules in normal and in diseased tissue.... Agent: Perkins Coie LLP

20080193949 - Methods for diagnosing and treating hemostatic disorders by modulating p-selectin activity: The present invention identifies P-selectin as a modulator of hemostasis. Accordingly, the present invention relates to methods for the identification and use of modulators of P-selectin activity as modulators of hemostasis. The invention also relates to methods and compositions for the diagnosis and treatment of hemostatic disorders, including, but not... Agent: Rissman Jobse Hendricks & Oliverio, LLP

20080193950 - Assay for cytochrome p450 isoform 2c9: A Rapid And Sensitive Radiometric Assay For Assessing The Activity Of Cytochrome P-450 (CYP) 2C9 And The Potential Of An Analyte To Inhibit CYP2C9 Activity Or Induce CYP2C9 Expression is described. All the steps of the assay, including incubations, product separation, and radioactivity counting are preferably performed in a multiwell... Agent: Merck And Co., Inc

20080193951 - Mn gene and protein: Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized MN protein. Such MN proteins/polypeptides prevent cell-cell adhesion and the formation of intercellular contacts. The MN protein binding site is a therapeutic target that can be blocked... Agent: Leona L. Lauder

20080193952 - Inducible nitric oxide synthase binds, s-nitrosylates, and activates cyclooxygenase-2: Cyclooxygenase (COX2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Inducible NOS specifically binds to COX2 and S-nitrosylates it, enhancing COX2 catalytic activity. Selectively disrupting iNOS-COX2 binding prevents NO-mediated activation of COX2. The synergistic molecular interaction between two inflammatory systems permits assays for developing anti-inflammatory drugs.... Agent: Banner & Witcoff, Ltd.

20080193953 - Convenient detection method, detection apparatus and detection kit: This invention provides a simple detection method with excellent sensitivity and specificity, which allows prompt detection of an analyte by allowing a labeled reagent to effectively react with the analyte in the process of treating an analyte-containing specimen, such as during removal of impurities, a detection apparatus, and a detection... Agent: Foley And Lardner LLP Suite 500

20080193954 - Method for identifying a subject at risk of developing heart failure by determining the level of galectin-3 or thrombospondin-2: The present invention relates to a method for identifying a subject at risk of developing hypertensive end organ damage, such as and in particular heart failure, comprising: a) obtaining a biological sample of said subject; b) determining the level of at least one non-myocytal marker in said sample; c) comparing... Agent: Meyertons, Hood, Kivlin, Kowert & Goetzel, P.c.

20080193955 - Kit and method for the detection of anti-hepatitis c virus (hcv) antibodies: The present invention provides a kit for the detection of anti-hepatitis C virus (HCV) antibodies using a double-antigen sandwich technique, said kit carries out the detection by the process ‘solid support-first antigen-HCV antibody to be detected-second antigen-enzyme linked substance-recognizable signal’, wherein one or more coupling reactions between the second antigen... Agent: Marshall, Gerstein & Borun LLP

20080193956 - Nanostructure enhanced luminescence: The present invention relates to nanostructures for use in luminescent assays as well as methods for the production of nano-sized tube and rods, including arrays of nanotubes and nanorods from a nylon.... Agent: Woodcock Washburn LLP

20080193957 - Diagnostic methods for measuring elastase activity levels: The present invention relates to methods and kits for the diagnosis and confirmation of Chronic Fatigue Syndrome (CFS) by measuring elastase activity in a patient sample, preferably a PBMC sample. The assays of the invention can also be used to characterize CFS, to determine the disease stage, the disease progression,... Agent: Bozicevic, Field & Francis LLP

20080193959 - Enzyme substrates: This invention provides new methods for detecting enzyme activity using enzyme substrates comprising an enzyme cleavable portion and a chromogenic portion. The enzyme cleavable portion is a β-D-ribofuranosyl group and the chromogenic portion forms a detectable indicator following enzyme cleavage. In one aspect of this invention the chromogenic β-D-ribofuranoside substrate... Agent: Whitham, Curtis & Christofferson & Cook, P.c.

20080193958 - Method for the high-speed detection and/or measurement of a lipase or phospholipase activity: i

20080193960 - Method for determination of glycosylated protein and determination kit: The present invention relates to a method for quantitative determination of an α-glycated peptide in a sample, comprising causing protease to act on a whole blood and/or blood cell sample, causing an elimination reagent containing one or a plurality of types of ketoamine oxidase to act on the resultant, eliminating... Agent: Foley And Lardner LLP Suite 500

20080193964 - Compositions and methods for regulation of calcium-dependent signaling in brain: Methods are provided for screening agents for activity as modulators of calcium signaling in brain tissue.... Agent: Hoxie & Associates Llc

20080193961 - Localized control of thermal properties on microdevices and applications thereof: The present invention relates to microfluidic devices (20), and in particular, heat management in such devices. To achieve desired thermal properties in selected areas of a microfluidic or nanofluidic device, selective removal or addition of material (thermal mass) can be effected in certain selected regions of the device to control... Agent: Blank Rome LLP

20080193963 - Method of determining the state of activation of a protein: The present invention relates to a method for determining the state of activation of a (poly)peptide, comprising the steps of: (a) immobilizing a (poly)peptide on a carrier; (b) attaching the (poly)peptide immobilized on the carrier to a force measuring device of a force spectroscope; (c) applying a pulling force to... Agent: Frost Brown Todd, Llc

20080193962 - Simple analysis method of drugs: The invention provides a method for simple, rapid and inexpensive analysis of drugs such as nicotine and other drugs which are accumulated in biological samples of addictive drugger of tobacco, stimulant drug and the like. The method comprises the steps of introducing the biological sample into an injection needle, inserting... Agent: Nixon & Vanderhye, Pc

20080193965 - Microorganism detection and analysis using carbohydrate and lectin recognition: Methods of binding and detecting a microorganism on a solid substrate. The microorganism is bound on a solid substrate covalently bound to a capture agent having a saccharide moiety. A lectin capable of binding to the microorganism and the saccharide moiety of the capture agent is added to the sample... Agent: Ian C. Mcleod Ian C. Mcleod, P.c.

20080193966 - Multiple-valent opsonophagocytic assay selection panel arrays and uses therefor: This application discloses a multivalent opsonophagocytosis assay that does not rely on counting of bacterial colonies to determine bacteria viability following opsonophagocytosis. Instead, the method uses a metabolic colorimetric indicator to determine if viable bacteria are present. Also disclosed are arrays that can be used to determine the viability of... Agent: Klarquist Sparkman, LLP

20080193967 - Colorimetric sensor constructed of diacetylene materials: Colorimetric sensors for detection of an analyte are disclosed. Methods of using the colorimetric sensor and a kit for the colorimetric detection of an analyte are also disclosed.... Agent: 3m Innovative Properties Company

20080193968 - Therapeutic uses of artificial nanostructures: The present invention provides a method for controlling the fate of mammalian cells or microorganisms by the enzymatic formation of intracellular nanostructures. Enzymatic reactions trigger the intracellular self-assembly to convert a proper precursor into another molecule or nanoobject that will aggregate inside cells or inside or between tissues or organs.... Agent: Law Offices Of Albert Wai-kit Chan, Pllc

20080193969 - Hemoglobin overexpression in fungal fermentations: The present invention relates to fungal host cells that are transformed with a nucleic acid construct encoding a fungal oxygen-binding proteins or fragments thereof that comprise the oxygen-binding domain. Upon transformation of the host cell with the construct, the oxygen-binding protein confers to the host cell improved fermentation characteristics as... Agent: Nixon & Vanderhye, Pc

20080193970 - Method for producing carotenoids and bacteria used therefor: The invention concerns a method for synthesizing non-photosynthetic carotenoids using photosynthetic bacteria while producing at least one photosynthetic carotenoid of which one of the synthesis intermediates is lycopene. The inventive method is characterized in that it comprises a number of steps: the deletion and insertion of specific genes; the culturing... Agent: Nixon & Vanderhye, Pc

20080193971 - Lactoferrin cleavage of neisserial proteins: Meningococcal antigens are cleaved by human lactoferrin. The invention is based on the identification of the cleavage products of this reaction, and provides a method for cleaving a neisserial polypeptide, comprising the step of mixing the polypeptide with a lactoferrin enzyme. The invention also provides polypeptides obtainable by this process... Agent: Novartis Vaccines And Diagnostics Inc.

20080193973 - Bacillus subtilis strain and its use in preparing pharmaceuticals for treating thrombosis: A new Bacillus subtilis strain and its use in preparing medicine for treating thrombosis are provided. Particularly, the use of fibrinolytic enzyme produced by Bacillus subtilis in preparing medicine for treating thrombosis is provided. The present invention also discloses a method for producing said fibrinolytic enzyme (nattokinase). It is efficient... Agent: Workman Nydegger

20080193974 - Bacterial leader sequences for increased expression: Compositions and methods for improving expression and/or secretion of protein or polypeptide of interest in a host cell are provided. Compositions comprising a coding sequence for a bacterial secretion signal peptide are provided. The coding sequences can be used in vector constructs or expression systems for transformation and expression of... Agent: Alston & Bird LLP

20080193972 - Gene rcs 25: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, Pc

20080193975 - Mutated d-aminotransferase and method for producing optically active glutamic acid derivatives using the same: A D-aminotransferase can be modified so as to efficiently produce (2R,4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by mutating the amino acid sequence of a wild-type D-aminotransferase represented in SEQ ID NO:4.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080193976 - Pseudomonas exotoxin a cd4+t-cell epitopes: The present invention provides PE CD4+T-cell epitopes, as well as novel variants that exhibit reduced immunogenic responses, as compared to the parental PE. The present invention further provides DNA molecules that encode novel PE variants, host cells comprising DNA encoding novel PE variants, as well as methods for making PEs... Agent: Medimmune, Llc

20080193977 - Gene expression technique: The present invention provides a method for producing a desired protein (such as a desired heterologous protein) comprising: (a) providing a host cell comprising a first recombinant gene encoding a protein comprising the sequence of a first chaperone protein, a second recombinant gene encoding a protein comprising the sequence of... Agent: Novozymes North America, Inc.

20080193979 - Method for generating diversity: The invention relates to a method for preparing an antibody-producing cell line capable of directed constitutive hypermutation of a specific nucleic acid region, comprising the steps of: a) screening a clonal cell population for V gene diversity; b) isolating one or more cells which display V gene diversity and comparing... Agent: Wilson Sonsini Goodrich & Rosati

20080193978 - Preparation of scfv antibody fragments: The invention relates to methods of preparing antibody fragments. The invention further relates to antibody fragments prepared by said methods. The invention further relates to antibody variable regions comprised in antibody fragments producible by said methods.... Agent: Fulbright & Jaworski L.l.p.

20080193980 - Fusion protein of fc-binding domain and calcium-binding photoprotein, gene encoding the same and use thereof: The invention provides a calcium-binding photoprotein which has a high ability to bind to IgG and is capable of more sensitively detecting IgG. A fusion protein of the present invention composed of a ZZ domain having the ability to bind to the Fc region of IgG and the calcium-binding photoprotein... Agent: Hogan & Hartson LLP Ip Group, Columbia Square

20080193981 - Polyelectrolyte precipitation and purification of proteins: Methods are presented for isolating and purifying proteins by adding a polyelectrolyte to a cell culture fluid, such as a harvested cell culture fluid, and precipitating a protein-polyelectrolyte complex or a complex of impurities and the polyelectrolyte.... Agent: Genentech, Inc.

20080193982 - Production of enzymes: The present invention relates to a process of producing desired enzyme(s) in a host cell, comprising cultivating said host cell capable of producing the desired enzyme(s) under conditions conducive for production of the desired enzyme(s) using a substrate for the host cell comprising liquefied and/or saccharified starch-containing plant material.... Agent: Novozymes North America, Inc.

20080193983 - Quasirandom structure and function guided synthesis methods: The present invention is directed to the synthesis of molecules guided b connector polynucleotides (CPNs capable of hybridizing to complementary connector polynucleotides (CCPNs) harbouring at least one functional entity comprising at least one reactive group. At least one of said CCPNs capable of hybridize to at least two CPNs. Each... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080193984 - Process for producing amino acid derivative from hydroxyimino acid: wherein R1 and n have the same meanings as those of R1 and n in the general formula (I), wherein the microorganism and/or the enzyme is capable of catalyzing the reaction.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080193985 - Method for recovering a basic amino acid form a fermentation liquor ll: The invention relates to a method for recovering a basic amino acid from the fermentation liquor of a micro-organism strain that produces the basic amino acid. According to said method: a) the fermentation liquor is acidified with an acid, whose pKs value in water at 25° C. ranges between 2... Agent: Connolly Bove Lodge & Hutz, LLP

20080193986 - Mutant strain of amycolatopsis orientalis and process for preparing vancomycin hydrochloride: The present invention provides a process for preparing vancomycin hydrochloride using a mutant strain of Amycolatopsis orientalis (accession No. KCCM-10836P) comprising the steps of i) mutating and isolating a strain of Amycolatopsis orientalis (accession No. KCCM-10836P) for producing vancomycin from mother strain of Amycolatopsis orientalis (accession No. ATCC-19795) using NTG(N-methyl-N′-nitro-N-nitrosoguanidine)... Agent: Kenyon & Kenyon LLP

20080193987 - Process for extracting and recovering polyhydroxyalkanoates (phas) from cellular biomass: A process for extracting and recovering polyhydroxyalkanoates (PHAs) from cellular biomass comprising the steps of: extracting the polyhydroxyalkanoate with at least one non-halogenated solvent which is non-aggressive to the environment; heating the cellular biomass, in order to form a suspension comprising PHA solvent with the dissolved PHA and insoluble residues;... Agent: Darby & Darby P.c.

20080193988 - Process for the preparation of sulfonamide derivatives: The invention relates to a process for the preparation of compounds of formula (I) wherein Q1 is a group selected from formulae (II) & (III) and a group *-NR6-Q2-A or, if appropriate, their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof, as well as intermediates used in... Agent: Pfizer Inc.

20080193989 - Energy efficient methods to produce products: The invention relates to processes that efficiently convert carbon-containing materials, such as biomass, into products in such a manner that the energy, carbon, and mass content of the materials are efficiently transferred into such products. Such methods include converting the materials into at least one intermediate by a biological conversion... Agent: Sheridan Ross Pc

20080193990 - Tow-step method for producing polyesterols: e

20080193991 - Process for improving the yield and efficiency of an ethanol fermentation plant: A process for improving the yield and efficiency of an ethanol fermentation plant that receives organic fermentable feedstock material, prepares the feedstock for fermentation, ferments the feedstock with yeast to produce ethanol, and produces stillage as a byproduct of ethanol fermentation. The process steps which can be operated independently or... Agent: Kirton And Mcconkie

20080193992 - Kluyveromyces strains metabolizing cellulosic and hemicellulosic materials: This invention relates to the use of microorganisms for the generation of ethanol from lignocellulosic waste materials. Yeast strains of the genus Kluyveromyces which have the capability to ferment cellulose, hexose sugars to ethanol are provided. Also provided are methods for converting cellulose, hexoses, or mixed hydrolysates of hexoses to... Agent: Knobbe Martens Olson & Bear LLP

20080193993 - Method and plant for producing biogas from bio-organic residual matters: The invention relates to a plant and method for producing a biogas from different organic waste materials from household, agriculture, forestry, industry and commerce sectors (bioorganic residues) by anaerobic alkaline sludge digestion. The aim of said invention, in particular, is to substantially reduce a production and energy costs and, thereby... Agent: Brooks Kushman P.c.

20080193994 - Systems and methods for the co-treatment of solid organic waste and sewage: Solid organic waste is processed into a suitable feedstock that can be mixed with sewage for anaerobic digestion. The processing of the solid organic waste initially transforms the solid organic waste into a uniform biomass. The uniform biomass is then subjected to hydrolysis and volatile acid fermentation to dissolve the... Agent: Carr & Ferrell LLP

20080193995 - Biological material fixed carrier enclosing tip, biological material fixed carrier treatment apparatus, and treatment method thereof: A biological material fixed carrier enclosing tip, a biological material fixed carrier treatment apparatus, and a treatment method thereof. An object is to obviate attachment control and suction control for storing and retaining the carrier in the tip form vessel, to simplify complex reaction processes, and to make processing of... Agent: Haynes And Boone, LLP

20080193996 - Methods for separating molecules: The present invention provides compositions and methods for the separation of metals or molecules such as polypeptides, nucleic acids, or endotoxins using a metal-modified solid support. The metals or molecules are isolated from a starting material using the modified solid supports of the invention. Also provided by the invention are... Agent: Michael Best & Friedrich LLP

20080193997 - Liquid preparation of physiologically active peptide: An effective liquid preparation achieves high bioavailability (BA) of physiologically active peptides or proteins, including ghrelins, that are administered as drugs. Also provided is a method for improving the BA of physiologically active peptides or proteins, including ghrelins, that are subcutaneously injected in aqueous solutions. The liquid preparation contains: a... Agent: Hunton & Williams LLP Intellectual Property Department

20080193998 - Enzymes: The present invention relates to modified GTP cyclohydrolase II enzymes that display increased specific activity, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing... Agent: Stephen M Haracz Bryan Cave LLP

20080193999 - Alpha-amylase variants with altered properties: The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: substrate specificity, substrate binding, substrate cleavage pattern, thermal stability, pH/activity profile, pH/stability profile, stability towards... Agent: Novozymes North America, Inc.

20080194001 - Chimeric virus for the treatment of cancer: The invention provides a chimeric virus and a method for its use in the treatment of cancer. In one embodiment, the chimeric virus includes a herpes simplex virus type-1 (HSV-1)/human papillomavirus type-16 (HPV-16) chimera useful in the treatment of an oral or pharyngeal cancer.... Agent: Hoffman Warnick Llc

20080194000 - Novel listeria monocytogenes bacteriophage and uses thereof: The present invention is directed to isolated Listeria monocytogenes bacteriophage, and methods of using Listeria monocytogenes bacteriophage, or polynucleotides and polypeptides derived therefrom, to control the growth or contamination of food products by Listeria monocytogenes. The present invention also contemplates the use of Listeria monocytogenes bacteriophage, and polynucleotides and polypeptides... Agent: Hunton & Williams LLP Intellectual Property Department

20080194002 - Compositions comprising viruses and methods for concentrating virus preparations: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.... Agent: Townsend And Townsend And Crew, LLP

20080194003 - System for producing food and feed: A system including a harvested plant material degradation system, a microbial growth system in fluid contact with the harvested plant material degradation system, and an intermediary animal system in biomass-transfer interaction with the microbial growth system is disclosed. The intermediary animal can be fed to a product animal for consumption... Agent: Jere Northrop

20080194004 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20080194005 - Transformation system in the field of filamentous fungal hosts: A novel transformation system in the field of filamentous fungal hosts for expressing and secreting heterologous proteins or polypeptides is described. The invention also covers a process for producing large amounts of polypeptide or protein in an economical manner. The system comprises a transformed or transfected fungal strain of the... Agent: Morgan & Finnegan, L.l.p.

20080194006 - Methods of releasing sporocysts from oocysts using controlled shear forces: Methods of releasing sporocysts/sporozoites from oocysts are provided wherein a solution of oocysts is subjected to controlled shear forces sufficient to rupture the oocysts walls and release sporocysts/sporozoites therefrom. A solution of oocysts is passed through a Microfluidizer® processor chamber unit under defined conditions of chamber diameter, chamber geometry, and... Agent: Pfizer Inc Steve T. Zelson

20080194007 - Methods for in situ acceleration of biological degradation of chlorohydrocarbon in a soil: The invention provides methods for in situ acceleration of biological degradation of chlorinated hydrocarbons in a soil. The invention particularly provides a method for in situ acceleration of biological degradation of chlorinated hydrocarbons in a soil comprising adding H2, CO2 and acetate.... Agent: Trask Britt

20080194008 - Methods for reducing chlorine dioxide associated corrosion: Methods for inhibiting chlorine dioxide associated corrosion in industrial equipment by treating industrial equipment (e.g., pipes, washers and other metallic, e.g., stainless steel surfaces) or process streams in contact with industrial equipment with one or more haloperoxidases, preferably, a chloroperoxidase, in an amount effective to reduce chlorine dioxide associated corrosion.... Agent: Novozymes North America, Inc.

20080194009 - Novel hvac pathogen neutralization system: A novel process neutralizes airborne pathogens by using microwave powered ultra violet light combined with catalyzed filters and impingement media made of a layer of Filtrite filter media or comparable brand filter media covering an aerogel blanket. The geometric design maximizes the efficiency of the UV light, and impingement of... Agent: Rodger T. Marentis

20080194010 - Three dimensional cell culture construct and apparatus for its making: The present invention relates to a three dimensional construct formed from non-biodegradable and non-cytotoxic polymers that provide an internal and external space for living cells to attach, proliferate and differentiate. The construct is composed of polymer struts and/or fibers which are joined together in a designed 3 dimensional pattern. The... Agent: Patent Docket Administrator Lowenstein Sandler Pc

20080194011 - Laser-micro-dissection method and device for laser-micro-dissection: The invention relates to a laser-micro-dissection method and to a device for laser micro-dissection. A dissection from a biological sample, which is applied to a planar carrier, is cut by means of laser pulses along a closed cutting line. The parameters, which determine the laser pulses and the cut lines,... Agent: Foley And Lardner LLP Suite 500

20080194012 - Microfluidic particle analysis method, device and system: The method, device, and system relate to particle analysis, and in particular, to a microfluidic device designed for trapping particles for analysis. Particles include beads and cells.... Agent: Perkins Coie LLP

20080194013 - Chromatography detection apparatus, detection method, and kit utilizing the same: This invention provides an immunochromatography detection apparatus exhibiting excellent convenience, sensitivity, and specificity, a detection method therefor, a kit using the same, and a method for producing such apparatus and kit, by constructing a solid-phase support, on which the conditions for the reaction wherein an analyte specifically binds to a... Agent: Foley And Lardner LLP Suite 500

20080194014 - Caps for sample wells and microcards for biological materials: A cover for a biological sample well tray, comprising a cap for sealing a sample well. The cap comprises a well lens for focusing light into the sample well and collecting light from the sample. In another aspect, the cap comprises an elongate portion configured to permit incoming light to... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080194015 - Algae mass-producing device having radiation source for hormesis: Algae are irradiated to obtain a hormesis so that its thickness is increased or its growth time is shortened. A cubic rack with an adhesion unit is used so that more algae are planted to be cultured on the adhesion unit through the irradiation for mass production.... Agent: Troxell Law Office Pllc

20080194017 - Culture insert carrier, culture insert and culture insert system: The present invention relates to a culture insert carrier, a culture insert and a culture system for culturing and testing of different kinds of cells, such as for example skin models. A culture insert carrier for supporting at least one culture insert in a culture tray having at least one... Agent: Volentine & Whitt Pllc

20080194016 - Tissue container, and devicer and method for providing such a tissue container with data: The invention relates to a container for containing tissue, comprising at least one receiving space for tissue and at least one information surface for arranging data, wherein the information can be arranged by means of a laser. The invention also comprises a device provided with a laser for arranging information... Agent: Renner Otto Boisselle & Sklar, LLP

20080194018 - Isolated myeloid-like bone marrow cell populations and methods of treatment therewith: The present invention provides an isolated myeloid-like bone marrow cell population comprising a majority of cells that are lineage negative, and which express both CD44 antigen and CD11b antigen. These cells have beneficial vasculotrophic and neurotrophic activity when intraocularly administered to the eye of a mammal, particularly a mammal suffering... Agent: Olson & Cepuritis, Ltd.

20080194020 - Methods for producing dendritic cells that have acquired ctl-inducing ability: The present inventors worked on elucidating the mechanism of antigen cross-presentation by dendritic cells, and revealed that foreign antigens taken up in dendritic cells are degraded by proteasomes after undergoing polyubiquitination. Based on the novel finding that polyubiquitination is involved in cross-presentation, the promotion of polyubiquitination was attempted by a... Agent: Foley & Lardner LLP

20080194019 - Tumor suppressor lkb1 kinase directly activates amp-activated kinase: The invention relates to modulation of LKB1 or AMP kinase protein activity for treating disorders including diabetes and cancer. The invention also relates to screening for agents that modulate the activity of LKB1 or AMP kinase protein, which are useful in the treatment of diabetes and cancer, as well as... Agent: Wolf Greenfield & Sacks, P.c.

20080194021 - Use of a gsk-3 inhibitor to maintain potency of culture cells: The present invention is directed to the culture of non-embryonic cells, that can differentiate into cell types of more than one embryonic lineage, in culture under conditions that maintain differentiation capacity during expansion; more particularly, culturing non-embryonic cells in the presence of at least one GKS-3 inhibitor, such as BIO.... Agent: Anne Brown Thompson Hine LLP

20080194024 - Culture of non-embryonic cells at high cell density: The present invention is directed to the culture of non-embryonic cells, that can differentiate into cell types of more than one embryonic lineage, at high densities in culture under conditions that maintain differentiation capacity during expansion; more particularly, culturing non-embryonic cells at high densities in the presence of a GKS-3... Agent: Anne Brown Thompson Hine LLP

20080194023 - Generating vascular smooth muscle cells in vitro from es cells: A simplified and inexpensive method for the in-vitro identification, isolation and culture of human vasculogenic progenitor cells is provided. The method and the progenitor cells provided herein can be used for in-vitro vascular engineering, treatment of congenital and acquired vascular and hematological abnormalities, for evaluation and development of drugs affecting... Agent: Martin D. Moynihan Prtsi, Inc.

20080194022 - Isolation and use of solid tumor stem cells: s

20080194025 - Stability of secondary metabolite mass production through synchronized plant cell cultures: This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from the procambium or cambium to promote the stability of the plant-derived biologically active substances production... Agent: Moore & Van Allen Pllc

20080194026 - Commercially viable process for in vitro mass culture of jatropha curcas: The present invention relates to a commercially viable process for in vitro mass culture of Jatropha curcas. The process for in vitro mass culture of Jatropha curcas is simple, faster, and suitable for production of disease-free root tubers of uniform quality and employs media with a reduced concentration of phytohormones.... Agent: Morrison & Foerster LLP

20080194027 - Compositions, methods and kits based on small nuclear rnas: The present invention includes methods for modulating the expression of a gene or mRNA in a cell using small nuclear RNAs comprising specific sequence and structural features and further comprising a nucleic acid cargo.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20080194028 - Highly potent hsirna mixtures and method for gene splicing: Compositions and methods for making the same and uses of the composition are provided where the composition has a plurality of dsRNA fragments with overlapping sequences, each fragment having a size in the range of 18-30 nt, such that the composition is formed by enzymatic digestion of one or more... Agent: Harriet M. Strimpel, D. Phil.

20080194029 - Method for increasing the ratio of homologous to non-homologous recombination: Gene targeting allows the deletion (knock out), the repair (rescuing) and the modification (gene mutation) of a selected gene and the functional analysis of any gene of interest. Targeting of nuclear genes has been a very inefficient process in most eukaryotes including plants and animals due to the dominance of... Agent: Clark & Elbing LLP

20080194031 - Alterations utilizing nanoparticles: Alterations utilizing nanoparticles. Certain embodiments of the invention are methods of delivering a substance to a target using a delivery-aid which includes nanoparticles. Those nanoparticles may be nanocarbon particles. Other embodiments are methods of delivering nanoparticles to a target involving placing a mask between a source of ballistic delivery of... Agent: Rader Fishman & Grauer Pllc

20080194030 - L-methionine producting microorganism and method of producing l-methionine using the microorganism: Disclosed herein are a method of preparing an L-methionine production strain by overexpressing proteins involved in L-methionine biosynthesis in an L-threonine production strain, a strain prepared by the method, and a method of producing L-methionine using the strain.... Agent: Casimir Jones, S.c.

20080194032 - Methods and compositions for curing persistent i-complex super-family plasmids: Methods are provided for curing a host cell of a persistent plasmid of the I-complex super-family. The method proceeds via the direct introduction of a second plasmid containing a gene expressing at least a portion of an I-complex super-family-type Inc RNA. The second plasmid may be cured from the host... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080187901 - Composition for cold preservation and perfusion of organs: The current invention provides a new organ preservation solution, suitable for machine perfusion, for maintaining viability of organs, parts of organs and tissues. This solution has been designed to overcome a number of problems associated with hypothermic machine perfusion of donor organs, in particular organs obtained from non-heart-beating donors. The... Agent: Foley And Lardner LLP Suite 500

20080187902 - Retention of counterions in the separative bioreactor: A bioreactor with an anode and a cathode, and a plurality of reaction chambers each having an inlet and an outlet and each including a porous solid ion exchange wafer having ion-exchange resins. Each of the reaction chambers is interleaved between a cation exchange membrane and an anion exchange membrane... Agent: Harry M. Levy Olson & Cepuritis, Ltd.

20080187903 - Hcv rna-dependent rna polymerase: The present invention features NS5B polypeptides from different clinically important HCV genotypes. The polypeptides can be used individually, or as part of a panel of RNA-dependent RNA polymerases, to evaluate the effectiveness of a compound to inhibit NS5B activity.... Agent: Merck And Co., Inc

20080187904 - Metal chelate-labelled pepetides: The invention concerns a process for the production of metal chelate-labelled peptide antigens, peptides obtainable by this process and their use in an immunological method of detection.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080187905 - Nucleic acid isolation using polidocanol and derivatives: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to... Agent: Roche Molecular Systems, Inc. Patent Law Department

20080187925 - Biomarkers of cancer risk and their use in cancer detection and prevention: Certain embodiments of the present invention provide methods for identifying subjects that have, or are at risk for developing, cancer and for determining the effectiveness of preventive cancer treatments.... Agent: Viksnins Harris & Padys Pllp

20080187907 - Catalytic production of biomakers from biological materials: An apparatus and method for detecting a biological material, such as bacterial spores (e.g. Anthrax) which reacts non-volatile biomarker precursors to volatile precursors by heating the biological material in the presence of a catalyst.... Agent: James Sonntag James Sonntag, Patent Attorney

20080187909 - Classification of breast cancer patients using a combination of clinical criteria and informative genesets: The present invention provides prognostic methods for conditions such as cancer, for example, breast cancer, comprising classifying an individual by a plurality of phenotypic, genotypic or clinical characteristics of the condition into a plurality of patient subsets, and analyzing the pattern of expression of prognosis-informative genes identified for that subset... Agent: Jones Day

20080187917 - Compositions and methods for repressing the ink4a and arf senescence pathways: The present invention relates to methods and compositions for regulating cell growth and development. In particular, the present invention relates to methods and compositions for repressing Ink4a and Arf pathways.... Agent: Casimir Jones, S.c.

20080187926 - Detection of small nucleic acids: The present invention relates to compositions and methods for the detection and characterization of interfering RNAs such as micro RNAs (miRNAs) and small interfering RNAs (siRNAs) and other short nucleic acid molecules. More particularly, the present invention relates to improved methods for the detection and quantitation of interfering RNA expression.... Agent: Casimir Jones, S.c.

20080187913 - Determination of genotype of an amplification product at multiple allelic sites: e

20080187920 - Diagnostics and therapeutics for diseases associated with an il-1 inflammatory haplotype: Methods and kits for determining whether a subject has or is predisposed to developing a disease which is associated with IL-1 polymorphisms and assays for identifying therapeutics for treating and/or preventing the development of these diseases are provided.... Agent: Beth Arnold Foley, Hoag LLP

20080187923 - Flow-cytometric heteroduplex analysis for detection of genetic alterations: The present invention provides methods and kits useful for the detection of genetic alterations and to diagnose a disease condition caused by a genetic alteration. The invention involves two different PCR products, one control “unaltered” product and one sample product, which may contain “altered” DNA, that are mixed, denatured, and... Agent: Davis Wright Tremaine LLP/los Angeles

20080187930 - Gene expression profiling based identification of genomic signature of high-risk multiple myeloma and uses thereof: The present invention discloses a method of gene expression profiling to identify genomic signatures linked to survival specific for a disease and a kit that can be used for performing such a method. Also disclosed herein is the use of such a method in classifying the disease into subsets, predicting... Agent: Benjamin Aaron Adler Adler & Associates

20080187908 - Granulocyte subtype-selective receptors and ion channels and uses thereof: The invention relates, in part, to granulocyte type selective markers that are preferentially expressed in granulocytes and their use in drug screening assays. Additionally, the granulocyte type selective markers are useful in the diagnosis and treatment of granulocyte disorders and in the assessment of the efficacy of therapies of granulocyte... Agent: Wolf Greenfield & Sacks, P.C.

20080187933 - Hdv nucleic acid molecules, fragments and applications thereof: The invention concerns nucleic acid molecules derived from novel hepatitis D virus strains or isolates constituting genotypes different from known I, II and III genotypes, their fragments, corresponding proteins and their uses as diagnostic reagents. The invention also concerns a method for sensitive diagnosis of the hepatitis D virus (or... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080187919 - Hpv primers: The present invention provides methods, kits, and compositions related to human papillomavirus (HPV) primers, which may be used, for example, in nucleic acid detection assays for use in basic research, clinical research, and for the development of clinical detection assays.... Agent: Casimir Jones, S.c.

20080187916 - Identification of cell culture contaminants among mollicutes species by a pcr based assay: The present invention encompasses nucleic acids, methods, compositions, and kits for sensitive, rapid and specific detection of Mycoplasma, Acholeplasma, Ureaplasma, Phytoplasma and Spiroplasma species in a sample. The invention utilizes specific primers and amplification methods that permit differentiation between species due to specific amplification of target nucleic acids of contaminating... Agent: Bio Intellectual Property Services (bio Ips) LLC

20080187914 - Induced heteroduplex generators: Heteroduplex band resolution is found to be improved by modifying the induced heteroduplex generator (IHG) molecule such that the identifier is spaced apart from the nucleotide position immediately adjacent to the site of the polymorphism which is to be genotyped. Unexpectedly, it is found that, when such modified IHG molecules... Agent: Welsh & Katz, Ltd

20080187906 - Method and kit for assessing the risk of cardiovascular pathologies with atheromatous etiology: The invention relates to a molecular method for in vitro assessment of the predisposition of a subject to develop cardiovascular pathologies, associated with rupture of an atherosclerotic plaque. The method is characterized by the identification of a polymorphism in the COX-2 gene promotor, using genomic DNA sample(s) of the subject... Agent: Knobbe Martens Olson & Bear LLP

20080187934 - Method and probes for the detection of chromosome aberrations: A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at least one set comprising one or more peptide nucleic acid probes capable of hybridising to specific nucleic acid sequences related to a... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080187929 - Method for determining preeclampsia risk: A method for determining the risk of a mother of a fetus to develop preeclampsia during pregnancy comprising: (a) providing a sample of genomic DNA from an individual related to the fetus; (b) analyzing the DNA for the presence of one or more mutations in the PP13 gene; and (c)... Agent: The Nath Law Group

20080187924 - Method for the treatment of a sample containing biomolecules: The invention generally provides a method for the sample preparation for a subsequent preparation, processing or analysis method of a sample containing an at least one species of nucleic acid and/or one species of protein, whereby the method comprises the following steps: A) providing a sample which contains at least... Agent: Womble Carlyle Sandridge & Rice, PLLC

20080187918 - Method of diagnosing the risk of thermolabile phenotype diseases by using gene: The invention relates to a method of diagnosing a risk of a thermolabile phenotype disease including or caused by influenza encephalitis/encephalopathy, Reye's syndrome, RS virus infectious disease, adenovirus infectious disease, rhinovirus infectious diseases, bastard measles, Japanese encephalitis, malaria infectious disease, Kawasaki disease and sudden infant death syndrome, characterized by examining... Agent: Sughrue Mion, PLLC

20080187922 - Method of screening drug-resistance protein of mycobacterium tuberculosis: The present invention belongs to the field of molecular biology. Specially, the invention relates to the screenings of a new drug target, a vaccine antigen and a test target of anti-tuberculosis treatment. Specially, based on the differential proteome technology and by the techniques of gene sequencing, in vitro protein expression,... Agent: Ladas & Parry

20080187911 - Methods and compositions for analysis of mitochondrial-related gene expression: The invention provides arrays for analyzing the expression of mitochondrial-related coding sequences. The invention allows the efficient analysis of expression levels across each of these coding sequences. The invention has important applications in the field of medicine for the screening and diagnosis of patients with ailments associated with aberrant mitochondrial... Agent: Fulbright & Jaworski L.L.P.

20080187921 - Methods and compositions for genetically detecting improved milk production traits in cattle: An isolated nucleic acid molecule comprising a polymorphic site selected from the group consisting of positions 164, 269, 284, 407 and 989 of SEQ ID NO: 1, an array or a kit comprising the same. Also provided are a method for detecting single nucleotide polymorphism (SNP) in bovine proteinase inhibitor... Agent: Kening Li Pinsent Masons

20080187928 - Methods for enhancing exercise performance: Disclosed herein are methods for enhancing one or more effects of exercise in a subject by administering a PPARδ agonist (e.g., GW1516) to the subject in combination with an exercise program. Also disclosed are gene expression profiles unique to the combination of agonist-induced PPARδ activation and exercise. Such profiles are... Agent: Klarquist Sparkman, LLP

20080187931 - Mutations associated with iron disorders: The invention features a method of diagnosing an iron disorder, e.g., hemochromatosis, or a genetic susceptibility to developing such a disorder in a mammal by determining the presence of a mutation in exon 2 or in an intron of an HFE nucleic acid.... Agent: Fish & Associates, PC Robert D. Fish

20080187910 - Nucleic acid assay and method of detecting the presence of a nucleic acid sequence: The present invention is directed to an assay and a method of detecting the presence of a specific sample nucleic acid sequence in a sample suspected of containing the same. The assay utilizes nucleic acid matrices to facilitate reactions which detect the presence of a nucleic acid sequence through formation... Agent: Watov & Kipnes, P.C.

20080187912 - Oligonucleotide arrays for high resolution hla typing: Arrays of HLA Class I oligonucleotide probes on a solid support are provided, wherein the probes are sufficient to represent at least 80% of the known polymorphisms in exons 2 and 3 of the HLA Class I locus.... Agent: Myers Bigel Sibley & Sajovec

20080187932 - Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to infection and asthma: A gene related to a susceptibility of infection and asthma—the Protein-Tyrosine Phosphatase Receptor-type Delta (PTPRD) gene—a method of detecting the asthma-associated gene, a method of predicting the occurrence of asthma, a method of identifying asthma-associated alleles in PTPRD gene, a method of screening PTPRD for drugs useful in the treatment... Agent: Baker & Mckenzie LLP

20080187915 - Systems and methods for controlling the position of a charged polymer inside a nanopore: Techniques for controlling the position of a charged polymer inside a nanopore are provided. For example, one technique includes using electrostatic control to position a linear charged polymer inside a nanopore, and creating an electrostatic potential well inside the nanopore, wherein the electrostatic potential well controls a position of the... Agent: William E. Lewis Ryan, Mason & Lewis, LLP

20080187927 - Using hug1 promoter and a reporter gene to detect genotoxicity and genoprotection: Methods are disclosed for genotoxicity testing and genoprotection testing using genetic constructs having a hydroxyurea- and UV- and gamma radiation-induced promoter linked to a reporter gene, such as green fluorescent protein.... Agent: Quarles & Brady LLP

20080187935 - Homo and heterodimer proteins of the abcg family, methods for detection and screening modulators thereof: The invention relates to methods for screening selective modulators of half transporter proteins of the ABCG family, more closely of ABCG1 and ABCG4. In particular the invention relates to methods for determining whether a substance is a selective activator, an inhibitor or a substrate of an ABCG1 or ABCG4 homodimer... Agent: Hahn & Voight PLLC

20080187936 - Identification of bitter ligands that specifically activate human t2r receptors and related assays for identifying human bitter taste modulators: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. The invention further relates to the use of these receptors in assays for identifying ligands that modulate the activation of these taste receptors by these bitter ligands... Agent: Hunton & Williams LLP Intellectual Property Department

20080187937 - Method for measuring dynamics of self-assembling systems of biological molecules in vivo and uses for discovering or evaluating therapeutic agents: The Applicants have established a simple, rapid assay of measuring the dynamics of self-assembling systems of biological molecules, based on stable isotope labeling technology that can be used in intact animals including humans. Examples of self-assembling systems of biological molecules include microtubule polymers, actin filaments, amyloid-beta plaques or fibrils, prion... Agent: Morgan, Lewis & Bockius, LLP

20080187940 - Transformed saccharomyces cerevisiae and method for mass-production of lk8 protein using the same: The present invention relates to a method for preparing LK8 protein, more precisely, a method for mass-production of LK8 protein using Saccharomyces cerevisiae transformed by a gene coding LK8 protein having angiogenesis inhibiting activity. The transformed strain of the present invention and production processes of LK8 protein are expected to... Agent: Gates & Cooper LLP Howard Hughes Center

20080187938 - Aldh1 as a cancer stem cell marker: The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides a novel stem cell cancer marker, ALDH1, useful for the diagnosis, characterization, and treatment of solid tumor stem cells.... Agent: Casimir Jones, S.c.

20080187939 - Protein kinase c gamma as a biomarker for neuropsychological and cognitive functions in the central nervous system: Embodiments of the present invention are directed to a biological marker, the gamma isoform of protein kinase C (PKCg), which surprisingly allows rapid identification of compromised cognitive, behavioral, and neuropsychological functions under conditions associated with acute, transient hypoxia in humans. It was surprisingly discovered that PKCg is released from neural... Agent: Novak Druce Deluca + Quigg LLP

20080187941 - Method for preparing fusion protein by trans-splicing method: An object to be achieved by the present invention is to provide a method that enables convenient production of a target fusion protein within a short time without constructing any expression vector. The present invention provides a method for producing a fusion protein comprising a first protein and a second... Agent: Sughrue Mion, PLLC

20080187942 - Methods of using chimeric receptors to identify autoimmune disease: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much... Agent: Peter G. Carroll Medlen & Carroll, LLP

20080187943 - 1,5-anhydroglucitol (1,5-ag) assay and a1c/1,5-ag assay combination for measuring blood glucose excursions in general and postprandial hyperglycemia in diabetic patients: The invention is a method of measuring blood glucose excursions in general, and postprandial hyperglycemia in diabetic patients in particular, by the 1,5-anhydroglucitol assay (1,5-AG) or A1C/1,5-AG assay combination. 1,5-AG levels and percent changes of 1,5-AG levels in short period are indicative of differing postmeal glucose levels in moderately-controlled diabetic... Agent: Darby & Darby P.C.

20080187944 - Butyrylcholinesterase as a marker of low-grade systemic inflammation: The present invention relates to a strategy or method of detecting, diagnosing, and prognosticating low-grade systemic inflammatory conditions such as insulin resistance, type 2 diabetes mellitus, hypertension, hyperlipidemias, and Alzheimer's disease; various cancers, and acute and chronic collagen vascular diseases including rheumatoid arthritis (RA), and lupus; proliferative diabetic retinopathy; macular... Agent: Undurti N. Das #321

20080187945 - Method for the detection of proteolytic enzymes: The present invention provides an improved protease assay in which the proteases are detected on basis of their capability to cleave a modified pro-caspase which will yield an activated caspase which can then further be detected. Also part of the invention are the modified pro-caspases and kits comprising said modified... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20080187946 - Apparatus for and method of detecting microorganism or micro-particle in real time by using electrical charging method: An apparatus for detecting a microorganism or micro-particle in real time includes an electrical charging module which electrically charges a microorganism or micro-particle in an atmosphere, a collection module which collects the electrically charged microorganism or micro-particle by using a potential difference, a preprocessing module which applies a fluorescent material... Agent: Cantor Colburn, LLP

20080187952 - Biomarkers of ionizing radiation response: The invention provides methods for measuring cellular response to ionization radiation (IR). The invention also provides a plurality of diagnostic and prognostic cancer biomarkers for assessing cellular response to IR.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080187947 - Cholesterol-mimetic pyrene probes: The invention concerns compounds called pyrene-cholesterols, of general formula (I), wherein: X represents a CH2 group or an oxygen atom and n is an integer from 2 to 10, as well as their use for implementing a method for detecting and measuring the effects of specific products on biological membranes,... Agent: Young & Thompson

20080187948 - Erbb heterodimers as biomarkers: A method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more heterodimers of ErbB, or Her, cell surface membrane receptors measured directly in a patient sample is described. The invention includes a method of determining a status of a... Agent: Monogram/fenwick

20080187951 - Hematological analyzer, method for analyzing body fluid and computer program product: A hematological analyzer for measuring blood, sets a body fluid measurement mode; receives a measurement start instruction; irradiates a measurement sample with light and obtains optical information from cells contained in the measurement sample; and classifies at least white blood cells and nucleated cells other than white blood cells contained... Agent: Sughrue Mion, PLLC

20080187950 - Identification and isolation of acute myeloid leukemia stem cells: Acute myeloid leukemia stem cells (AMLSC) are identified. The cells can be prospectively isolated or identified from patient samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and in cancer diagnosis.... Agent: Bozicevic, Field & Francis LLP

20080187949 - Multiplexed assays of cell migration: Systems, including methods, apparatus, compositions, and kits, for multiplexed assay of cell migration with subdivided cell holders and/or microplates.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080187953 - Neomycin-phosphotransferase-genes and methods for the selection of recombinant cells producing high levels of a desired gene product: The invention relates to modified neomycin phosphotransferase genes and their use in a selection method for high-producing recombinant cells. The invention further relates to expression vectors which contain a modified neomycin phosphotransferase gene and a gene of interest functionally linked to a heterologous promoter and a method of preparing heterologous... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20080187956 - Aldehyde tags, uses thereof in site-specific protein modification: The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a formylglycine (FGly) residue. The aldehyde moiety of FGly residue can be exploited as... Agent: Bozicevic, Field & Francis LLP

20080187955 - Erythropoietin: remodeling and glycoconjugation of erythropoietin: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.... Agent: Morgan, Lewis & Bockius LLP (sf)

20080187954 - Method for producing antibodies: A novel method for expression of immunoglobulines is devised.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080187957 - Method for sequence specific biotinylation: A method of preparing a biotinylated polypeptide in a cell-free peptide synthesis reaction mixture by contacting, under suitable conditions, a polypeptide to be biotinylated, with a reaction mixture that includes ribosomes, tRNA, ATP, GTP, nucleotides, biotin and amino acids, and a polypeptide that includes an enzymatically active domain of a... Agent: Hoffmann-la Roche Inc. Patent Law Department

20080187964 - Aspergillus niger promoter for expressing genes in host cells: The present invention relates to isolated promoter sequences, particularly a promoter isolated from Aspergillus niger designated herein as A4-L or A4 and DNA constructs and vectors including the same.... Agent: Genencor International, Inc. Attention: Legal Department

20080187960 - Non-cytotoxic protein conjugates: A non-cytotoxic protein conjugate for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell, comprising: (i) a Targeting Moiety (TM), wherein said TM is an agonist of a receptor present on said nociceptive sensory afferent cell, and wherein said receptor undergoes endocytosis to be incorporated into an... Agent: Merchant & Gould PC

20080187961 - Polynucleotides encoding signal peptide-containing molecules: The invention provides human signal peptide-containing proteins (HSPP) and polynucleotides which identify and encode HSPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HSPP.... Agent: Foley And Lardner LLP Suite 500

20080187962 - Polypeptides, polynucleotides and uses thereof: A recombinant polynucleotide encoding migrating stimulating factor (MSF) or variants or fragments or derivatives or fusions thereof or fusions of said variants or fragments or derivatives. Reagents are disclosed which can distinghish MSF and fibronectin, and which can distinguish polynucleotides which encode MSF or fibronectin. These reagents are believed to... Agent: Knobbe Martens Olson & Bear LLP

20080187958 - Subtilases: The present invention relates to novel JP170 like subtilases from wild-type bacteria, hybrids thereof and to methods of construction and production of these proteases. Further, the present invention relates to use of the claimed subtilases in detergents, such as a laundry or an automatic dishwashing detergent.... Agent: Novozymes North America, Inc.

20080187959 - Sulfotransferase, peptide thereof and dna encoding the same: A glycosaminoglycan sulfotransferase, a peptide thereof, a nucleic acid comprising a nucleotide sequence encoding the same, an enzyme agent for the synthesis of a glycosaminoglycan, which comprises the above-described enzyme or polypeptide, and a process for producing a glycosaminoglycan, which uses the enzyme agent.... Agent: Sughrue Mion, PLLC

20080187963 - Use of lepa for improving the accuracy of protein synthesis in vitro: The present invention relates to methods, systems, compositions and kits for the synthesis of proteins in vitro, wherein the protein synthesis is carried out in the presence of the ribosomal factor LepA in order to significantly improve the accuracy of protein synthesis.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080187966 - Antibodies and methods for making and using them: The present invention provides methods for producing humanized antibodies and increasing the yield of antibodies and/or antigen binding fragments when produced in cell culture. In one aspect of the invention, at least one framework region amino acid residue of the variable domain is substituted by a corresponding amino acid from... Agent: Morrison & Foerster LLP

20080187965 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080187967 - Device and method for the production of biologically active compounds by fermentation: The present invention relates to a process and an apparatus for the fermentational production of biologically active materials, wherein a fermenter is located in an insulator which, in turn, is located within a working chamber or is adjacent to it. A pressure gradient in relation to ambient pressure prevails in... Agent: The Firm Of Hueschen And Sage

20080187968 - Emulsion compositions: An emulsion is useful in allowing a wide variety of gene products to be expressed via eukaryotic in vitro expression. The emulsion comprises a silicone based surfactant, a hydrophobic phase and a hydrophilic phase; wherein the hydrophilic phase comprises a plurality of compartments containing a functional in vitro eukaryotic expression... Agent: Edwards Angell Palmer & Dodge LLP

20080187969 - Nucleic acid amplification using non-random primers: The present invention provides methods for selectively amplifying a target population of nucleic acid molecules (e.g., all mRNA molecules expressed in a cell type except for the most highly expressed mRNA species). The present invention also provides populations of oligonucleotides including the nucleic acid sequences set forth in SEQ ID... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20080187970 - Beta-fructofuranosidase variants: An object of the present invention is to provide a β-fructofuranosidase variant whose reaction specificity is improved to be suitable for the production of fructooligosaccharides. According to the present invention, there is provided a β-fructofuranosidase variant consisting of a mutated amino acid sequence of SEQ ID NO: 2 or a... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080187971 - Glucoamylase variants: The invention relates to a variant of a parent fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates.... Agent: Novozymes North America, Inc.

20080187972 - Saponin-decomposing enzyme, gene thereof and large-scale production system for producing soyasapogenol b: The present invention provides a protein having saponin-decomposing activity, more specifically a protein which can decompose a glycoside having soyasapogenol B as an aglycone to produce soyasapogenol B, a polynucleotide encoding such a protein, and a method of producing soyasapogenol B on a large scale using the same. A protein... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080187973 - Ethanol production using xylitol synthesis mutant of xylose-utilizing zymomonas: Production of ethanol using a strain of xylose-utilizing Zymomonas with a genetic modification of the glucose-fructose oxidoreductase gene was found to be improved due to greatly reduced production of xylitol, a detrimental by-product of xylose metabolism synthesized during fermentation.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080187974 - Process for preparing ethyl tert-butyl ether using ethanol dewatered by a membrane process: A process for preparing ethyl tert-butyl ether (ETBE) using low-water ethanol obtained by membrane dewatering at least two streams of relatively water-rich ethanol that have a different water content. by dewatering at membranes.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080187975 - Process for rapid anaerobic digestion of biomass using microbes and the production of biofuels therefrom: A process for effecting anaerobic digestion of plant biomass, which entails the step of anaerobically digesting plant biomass with at least one species of rumen microorganisms.... Agent: Dickinson Wright PLLC

20080187976 - Three-step biomethanation process: A triphasic biomethanation process, to convert starch or sugary agricultural feed stock into a methane rich gas mixture for facilitating generation of biogas to be used as kitchen fuels, electrical power or transportation from renewable biomass in a cost-effective manner. The process brings about conversion of starch-rich or sugar-rich biomass... Agent: Brooks Kushman P.C.

20080187977 - Method for production of physiologically active substance-immobilized substrate: An object of the present invention is to provide a method for production of a physiologically active substance-immobilized substrate, which can prevent the inactivation of a physiologically active substance and/or can immobilize a physiologically active substance at a high concentration onto a substrate surface without use of electrostatic attraction. The... Agent: Sughrue Mion, PLLC

20080187978 - Anti-inflammatory medicaments: Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.... Agent: Hovey Williams LLP

20080187979 - Method for preparing sample solution and sample solution preparing apparatus: A method for preparing a sample solution, which is a step preceding a process for separating and purifying a nucleic acid by extracting a nucleic acid from the sample solution, the method comprising: injecting a sample solution into a container for preparation; subjecting the sample solution to a treatment of... Agent: Birch Stewart Kolasch & Birch

20080187980 - Method for identifying potential agonists or antagonists using the three-dimensional structure of caspase-7: The present invention relates to a data storage medium encoded with the structural coordinates of crystallized molecules and molecular complexes which comprise the active site binding pockets of caspase-7. Such data storage material is capable of displaying such molecules and molecular complexes, or their structural homologues, as a graphical three-dimensional... Agent: Ropes & Gray LLP

20080187981 - Thermo-stable bio-matrix: A method for producing a thermo-stable biodegradable medium for storage of biological materials is disclosed. The method includes the preparation of a bio polymer as a matrix for biological materials. The biological material can be selected from a wide range which includes cellular organisms and micro-organisms. The medium can be... Agent: Knobbe Martens Olson & Bear LLP

20080187982 - Methods for removal of non-living plant matter: A method of accelerating decomposition of non-living plant material from a ground surface. The method employs the application of a saprotroph containing suspension to non-living plant material such as leaves or the stubble of a cultivated crop. The suspension is formulated with a pH and nutrient level whereby the physiologic... Agent: Eric S. Heinz

20080187983 - Artemisinic epoxide and methods for producing same: The present invention provides artemisinic epoxide, and methods of synthesizing artemisinic epoxide in a genetically modified host cell. The present invention further provides methods for producing artemisinin. The present invention further provides variant enzymes that catalyze the oxidation of amorpha-4,11-diene to artemisinic epoxide; nucleic acids encoding the variant enzymes; as... Agent: Bozicevic, Field & Francis LLP

20080187984 - Myo-inositol oxygenases: The invention provides methods and materials related to the production of organic products such as glucuronic acid, ascorbic acid, and glucaric acid. Specifically, the invention provides cells, methods for culturing cells, isolated nucleic acid molecules, and methods and materials for producing various organic products such as glucuronic acid, ascorbic acid,... Agent: Cargill, Incorporated

20080187985 - High density growth of t7 expression strains with auto-induction option: A bacterial growth medium for promoting auto-induction of transcription of cloned DNA in cultures of bacterial cells grown batchwise is disclosed. The transcription is under the control of a lac repressor. Also disclosed is a bacterial growth medium for improving the production of a selenomethionine-containing protein or polypeptide in a... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory

20080187986 - High density growth of t7 expression strains with auto-induction option: A bacterial growth medium for promoting auto-induction of transcription of cloned DNA in cultures of bacterial cells grown batchwise is disclosed. The transcription is under the control of a lac repressor. Also disclosed is a bacterial growth medium for improving the production of a selenomethionine-containing protein or polypeptide in a... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory

20080187987 - Composite yeast suitable for high concentration alcohol fermentation: The present invention relates to a composite yeast for high concentration alcohol fermentation, which includes thermostable Saccharomyces cerevisiae, acid protease, phytase, cellulose, β-glucanase, and pectinase, and is suitable for the high concentration alcohol fermentation for various raw materials. In addition to normal fermentation, the composite yeast of the present invention... Agent: Frommer Lawrence & Haug

20080187988 - Cytoplasmic antigens for detection of candida: The present invention relates to a method and a means of diagnosing Candida infection. In particular the present invention relates to a method of diagnosing Candida infection by measuring the levels of antibody to Candida cytoplasmic antigen present in a biological sample taken from a subject at risk of, or... Agent: Foley And Lardner LLP Suite 500

20080187989 - Apparatus and method for rapid reliable electrothermal tissue fusion: Pieces of tissue are fused together by compressing the pieces together at an interface, delivering an impulse of electrical power which is converted into sufficient thermal energy to fuse the pieces together at the interface. The impulse and the fusion occur within a preferable time of 0.5-2.0 seconds but no... Agent: John R Ley, LLC

20080187990 - Sample analyzer and computer program product: A sample analyzer prepares a measurement sample from a blood sample or a body fluid sample which differs from the blood sample; measures the prepared measurement sample; obtains characteristic information representing characteristics of the components in the measurement sample; sets either a blood measurement mode for measuring the blood sample,... Agent: Sughrue Mion, PLLC

20080187991 - Process for sorting motile particles from lesser-motile particles and apparatus suitable therefor: Motile particles are sorted from non-motile particles in a microfluidic sorting device wherein a stream of sort fluid containing motile and non-motile particles is caused to flow adjacent a media stream in non-turbulent fashion through a sort channel, during which flow motile particles cross the interface between the adjacent flow... Agent: Casimir Jones, S.c.

20080187992 - Methods for inhibiting tumor cell proliferation: The subject invention concerns methods for inhibition of STAT biological functions using platinum complexes.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080187993 - Method and antisense composition for selective inhibition of hiv infection in hematopoietic cells: A method and conjugate for selectively targeting activated hematopoietic cells, e.g., macrophage or T-lymphocyte cells, are disclosed. The conjugate is composed of a substantially uncharged antisense compound targeted against HIV, and a reverse TAT (rTAT) polypeptide coupled covalently to the antisense compound. The rTAT polypeptide is effective to produce selective... Agent: Perkins Coie LLP

20080187994 - Small peptides and methods for stabilizing the cell membrane of an immune cell: Methods for treating cutaneous inflammation, are described. Also described is a method for inhibiting the mucous release into airways of a patient, a method for blocking IgE activation of a lymphocyte, a method for stabilizing the cell membrane of a lymphocyte, thereby preventing their further involvement in the increased inflammatory... Agent: Lathrop & Gage Lc

20080187995 - use of topographic cues to modulate stem cell behaviors: Surfaces, kits, and methods for the modulation of cell behavior in vitro by patterned nanoscale topography. The invention is particularly useful for providing means to affect and control the growth and differentiation of human embryonic stem cells.... Agent: Brinks Hofer Gilson & Lione

20080187996 - Nanofibers, nanofilms and methods of making/using thereof: Described herein are compositions for making nanofibers and nanofilms composed of metal oxides, organic polymers, or combinations thereof. Also described herein are methods for making nanofibers and nanofilms where the fibers are formed from a solution having more than one solvent, where the solvents are immiscible. Nanofibers and nanofilms composed... Agent: Corning Incorporated

20080187997 - Novel lentiviral packaging cells: Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing recombinant retroviruses from the cell lines. Retroviruses produced by the cell lines include lentiviruses, such as HIV, capable of transferring heterologous DNA to... Agent: Lahive & Cockfield, LLP

20080187998 - Sulfonamide-based oligomers and polymers for destabilization of biological membranes: Oligomeric sulfonamides for use as endosomolytic reagents for transfection with polymeric or lipid-based vectors are described. A mixture of an oligomeric sulfonamide with a polymeric or lipid-based gene carrier and a nucleic acid results in a polyplex that exhibits 6-12-fold better gene expression than controls. A method of transfecting cells... Agent: Alan J. Howarth

20080188000 - Methods and compositions for modification of the human glucocorticoid receptor locus: Disclosed herein are methods and compositions for inactivation of the human glucocorticoid receptor (GR) gene by targeted cleavage of genomic DNA encoding the GR. Such methods and compositions are useful, for example, in therapeutic applications which require retention of immune function during glucocorticoid treatment.... Agent: Robins & Pasternak

20080187999 - Methods and systems for high homologous recombination (\"hr\") targeting efficiency: Disclosed are vectors, kits and methods useful in the construction of recombinant cells and DNAs via enhanced efficiency homologous recombination. The vectors are targeting vectors that contain a gene-of-interest spliced between two ends that are homologous to a genome target site. The ends of the vector may be protected from... Agent: Joseph E. Zahner

20080188001 - Methods for gene targeting: The present invention provides methods for generating and characterizing gene targeting events by using tags. More specifically, the invention employs methods to enrich for cells that have undergone the desired targeting event.... Agent: Michael Strathmann