Chemistry: molecular biology and microbiology inventions 07/08

20080182233 - Methods and compositions for depleting specific cell populations from blood tissues: The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover even rare cell types in high yield.... Agent: Fish & Richardson P.C.

20080182234 - Methods and compositions for modulating adenosine triphosphate (atp) in cells and preventing cell injury or death via post-translational modifications to atp synthase: Compositions and methods for modulating adenosine triphosphate (ATP) in cells via altering post-translational modifications of ATP synthase subunits or precursors thereof such as the ATP synthase β chain and its precursor are provided. These compositions and methods are useful in preconditioning organs and preventing cell injury or cell death via... Agent: Licata & Tyrrell P.C.

20080182235 - Detection of analytes in samples using liposome-amplified luminescence and magnetic separation: The invention relates to the encapsulation of luminescence-related molecules, including but not limited to, adenosine triphosphate (ATP), adenylate kinase (AK), alkaline phosphatase (ALP), luminol and luciferin/luciferase cocktails, within liposomes. These liposomes can be employed to enhance the luminescence detection of microorganisms and compounds in various products and samples. The liposomes... Agent: Loeb & Loeb, LLP

20080182253 - Automated method for detecting cancers and high grade hyperplasias: Automated methods for detecting cancer and related hyperplasias in biological samples.... Agent: Kelley Drye & Warren LLP

20080182256 - Corn event das-59122-7 and methods for detection thereof: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DAS-59122-7 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and... Agent: Pioneer Hi-bred International, Inc.

20080182257 - Detection of chromosomal region copy number changes to diagnose melanoma: This invention provides methods of detecting melanoma. The methods comprises detecting a gain or loss of certain chromosomal regions that undergo copy number changes in melanoma.... Agent: Townsend And Townsend And Crew, LLP

20080182254 - Detection of nucleic acids by multiple sequential invasive cleavages: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a... Agent: Casimir Jones, S.c.

20080182249 - Expression systems for mammalian and mycobacterial desaturases: Expression system for components of a desaturase complex is provided. The system includes expression of a desaturase and an oxidoreductase. The system may be used for expression of mycobacterial desaturases or for expression of mammalian desaturases. The system may further include cell-free expression of other components of the desaturase complex.... Agent: Brinks Hofer Gilson & Lione

20080182255 - Gene expression profiling in biopsied tumor tissues: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon... Agent: Goodwin Procter LLP Attn: Patent Administrator

20080182252 - Genotyping hla loci: This invention provides for an improved method for genotyping HLA loci using PCR.... Agent: Townsend And Townsend And Crew, LLP

20080182241 - Identification and use of cytochrome p450 nucleic acid sequences from tobacco: The present invention relates to P450 enzymes and nucleic acid sequences encoding P450 enzymes in plants, more specifically tobacco, and methods of using those enzymes and nucleic acid sequences to alter plant phenotypes.... Agent: Fish & Richardson P.C.

20080182250 - Method for detecting multiple myeloma and method for inhibiting the same: It is an object of the present invention to identify a gene that relates to exhibition of behavior peculiar to cancer such as multiple myeloma to provide a method for detecting cancer and a cell-growth inhibitor. The present invention provides a method for detecting cancer which comprises detecting and/or typing... Agent: Birch Stewart Kolasch & Birch

20080182269 - Method for identifying gene function: Methods are provided which utilize promoter hairpin constructs to suppress gene expression and thereby identify function of a gene of interest. Also provided are methods for restoring the original phenotype.... Agent: Pioneer Hi-bred International, Inc.

20080182259 - Method for judging lymph node metastasis of stomach cancer and kit used therefor: The present invention provides a novel marker capable of accurately diagnosing the lymph node metastasis of stomach cancer. An mRNA, or a fragment thereof, coding for at least one protein selected from TFF1, AGR2, PRSS8, MUC1, MUC4 and MUC17 can be useful as a lymph node metastasis marker.... Agent: Sughrue Mion, PLLC

20080182265 - Method for measuring the number of oral streptococci and a pcr primers-probe set used for the same: The object can be solved by a method for measuring the number of oral streptococci using the combination of a forward primer comprising a primer oligonucleotide part of at least 15 sequential bases in the base sequence of SEQ ID NO: 1 and a reverse primer comprising a probe oligonucleotide... Agent: Heslin Rothenberg Farley & Mesiti PC

20080182267 - Method for predicting a drug transport capability by abcg2 polymorphisms: The present invention provides polymorphisms of ABCG2 polypeptide and polynucleotide coding therefor, which is related to the intracellular accumulation of indolocarbazole compounds, as well as methods for detecting the polymorphisms, comprising collecting a sample from mammals, and determining a polymorphism of the nucleotide sequence of ABCG2 gene or a polymorphism... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080182260 - Method for quantifying a ratio between at least two nucleic acid sequences: The invention provides a method for quantifying an initial ratio of the amounts of at least two nucleic acids of interest in a sample by means of a multiplex nucleic acid amplification reaction, comprising amplifying the nucleic acids of interest in the amplification reaction, measuring the amount of at least... Agent: Trask Britt

20080182262 - Methods and compositions for risk stratification: The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in... Agent: Bozicevic, Field & Francis LLP

20080182245 - Methods and compositions involving microrna: The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.... Agent: Fullbright & Jaworski L.L.P.

20080182247 - Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory disease: The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering... Agent: Casimir Jones, S.c.

20080182242 - Methods for isolating novel antimicrobial agents from hypermutable mammalian cells: Dominant-negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into mammalian cells new cell lines with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation or introduction of mutations by... Agent: Woodcock Washburn LLP

20080182246 - Methods of predicting distant metastasis of lymph node-negative primary breast cancer using biological pathway gene expression analysis: The present invention provides a method for predicting distant metastasis of lymph node negative primary breast cancer by obtaining breast cancer cells; isolating nucleic acid and/or protein from the cells; and analyzing the nucleic acid and/or protein to determine the presence, expression level or status of a Biomarker selected from... Agent: Philip S. Johnson Johnson & Johnson

20080182239 - Methods, compositions, and kits for detection of microrna: The present invention provides methods, nucleic acids, compositions, and kits for detecting microRNA (miRNA) in samples. The methods comprise designing mRNA-specific primers, adding a polyA tail to the miRNA, and using reverse transcription and amplification to detect the miRNA. The nucleic acids, compositions, and kits typically comprise some or all... Agent: Agilent Techologies Inc

20080182261 - Non-invasive method for isolation and detection of fetal dna: A method of detecting the presence or absence of the fetal DNA sequence of interest in fetal DNA derived from a sample of peripheral blood obtained from a pregnant woman is described. The method involves obtaining a sample peripheral blood from a pregnant woman, treating the sample of peripheral blood... Agent: Lahive & Cockfield, LLP

20080182248 - Parallel genotyping of multiple patient samples: The present invention relates to parallel genotyping (or other sample analysis) of multiple patients by direct sample immobilization onto microspheres of an array. The patient beads can then be used in a variety of target analyte analyses.... Agent: Mcdermott, Will & Emery

20080182244 - Pre-implantation genetic diagnosis test: A method for determining viable normal blastomeres for implantation entailing labeling the blastomere with an antibody to hyperglycoslyated hCG and determining the binding of chromosomal probes directed to chromosomal regions of the chromosome.... Agent: Kelley Drye & Warren LLP

20080182238 - Process and apparatus for reducing interferences in biochemical assays: A method of conducting a biochemical assay that allows for a reduction of assay interferences. The method comprises treating a mixture of cell sample and cell constituents solubilizing agent, with an insoluble agent prior to conducting the assay. There is also provided a device as well as a kit for... Agent: Harness, Dickey & Pierce, P.L.C

20080182258 - Q3 sparc deletion mutant and uses thereof: The invention provides for SPARC polypeptides with a mutation corresponding to a deletion of the third glutamine in the mature form of the human SPARC protein, nucleic acids encoding such polypeptides, antibodies against such polypeptides, and methods of the use of such polypeptides, nucleic acids, and antibodies.... Agent: Leydig Voit & Mayer, Ltd

20080182268 - Schizophrenia associated genes, proteins and biallelic markers: The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080182264 - Systems and methods for baseline correction using non-linear normalization: Systems and methods for normalizing detected emission data collected in real-time polymerase chain reaction (RT-PCR) and other reactions, are provided. In some embodiments, a sample plate can be loaded with a fluorescent dye and subjected to a real-time PCR reaction. During the initial cycles, detected emissions that correspond to the... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080182263 - Systems and methods for calibration using dye signal amplification: The present teachings relate to a method of generating calibration information during a real-time polymerase chain reaction (RT-PCR) or other amplification reaction. A sample well plate or other support can contain one or more dyes or other reference materials that are subjected to the same RT-PCR thermal cycles or other... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080182243 - Systems for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: Searete LLC Clarence T. Tegreene

20080182266 - Trp8, a transient receptor potential channel expressed in taste receptor cells: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion... Agent: Nixon Peabody LLP - Patent Group

20080182251 - Ultra low strength electric field network-mediated ex vivo gene, protein and drug delivery in cells: Ex vivo gene, protein or drug delivery to macroscopic quantities of various types of cells, cell clusters, or tissues using ultra low strength LSEFN strategies is disclosed in which the bioengineered cells and tissues are then systemically transfused, delivered or implanted into the various organs or tissue for the treatment... Agent: Myers Dawes Andras & Sherman, LLP

20080182240 - Uses and methods of making microarrays of polymeric biomaterials: A microarray of polymeric biomaterials is provided. Specifically, a microarray of polymeric biomaterials that comprises a base with a cytophobic surface, and a plurality of discrete polymeric biomaterial elements bound to the cytophobic surface, is provided. Preferably said polymeric biomaterials comprise a synthetic polymer. Said polymeric biomaterials may also comprise... Agent: Choate, Hall & Stewart LLP

20080182271 - Methods for screening and therapeutic applications of kinesin modulators: The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The present invention also provide methods and compositions for treatment of disorders mediated... Agent: Townsend And Townsend And Crew, LLP

20080182273 - Microfluidic free interface diffusion techniques: A static fluid and a second fluid are placed into contact along a microfluidic free interface and allowed to mix by diffusion without convective flow across the interface. In accordance with one embodiment of the present invention, the fluids are static and initially positioned on either side of a closed... Agent: Townsend And Townsend And Crew, LLP

20080182274 - Monitor proteins usable for analyzing expression of membrane proteins: A monitor protein for measuring the expression of a membrane protein on a cell membrane is provided. The monitor protein includes a fusion protein in which the membrane protein and a luminescence protein are linked. Also provided are a DNA encoding the monitor protein; an expression vector for the DNA;... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080182272 - Rapid resuscitation, growth, capture and detection of microorganisms: A method and system for the detection and identification of a target pathogen in a sample is disclosed. The method and system involve the use of a capture matrix throughout resuscitation, growth, and detection. The method includes the steps of: placing the sample in a sampling container containing a medium... Agent: Patton Boggs LLP

20080182276 - Method and quantification assay for determining c-kit/scf/pakt status: This invention provides methods for determining or predicting response to cancer therapy in an individual using differential image analysis of immunohistochemically stained tumor samples.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080182277 - Assays and methods using biomarkers: Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of GalNac-T related molecules, such as GalNac-T14 or GalNac-T3, is predictive or indicative that the tissue or cell sample will... Agent: Genentech, Inc.

20080182278 - Identification and isolation of transitional cell carcinoma stem cells: Transitional cell carcinoma stem cells (TCCSC) are identified. The cells can be prospectively isolated or identified from primary tumor samples, and are shown to possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation, and in cancer diagnosis.... Agent: Bozicevic, Field & Francis LLP

20080182279 - Method of detecting broad-spectrum delta-endotoxins: Disclosed are novel synthetically-modified B. thuringiensis chimeric crystal proteins having improved insecticidal activity against coleopteran, dipteran and lepidopteran insects. Also disclosed are the nucleic acid segments encoding these novel peptides. Methods of making and using these genes and proteins are disclosed as well as methods for the recombinant expression, and... Agent: Howrey LLP

20080182275 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Heller Ehrman LLP

20080182280 - Methods of diagnosing inflammatory bowel disease: The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with inflammatory bowel disease (IBD) or a clinical subtype thereof. In particular, the present invention is useful for classifying a sample from an individual as an IBD sample using a statistical... Agent: Townsend And Townsend And Crew, LLP

20080182281 - Antibody directed against gastrin-releasing peptide precursor and use thereof: Disclosed is a novel method for determination of ProGRP which is free from problems such as the dispersion in the values of measurements and operational constraints such as handling of a test sample. A method for the determination of a gastrin-releasing peptide precursor or a digest thereof using at least... Agent: Edwards Angell Palmer & Dodge LLP

20080182282 - Methods for comparitive analysis of carbohydrate polymers and carbohydrate polymers identified using same: Disclosed is a method for characterizing a carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080182283 - Inhibitors of human plasmin derived from the kunitz domains: This invention provides: novel proteins, which are homologous to the first Kunitz domain (K1) of lipoprotein-associated coagulation inhibitor (LACI), and which are capable of inhibiting plasmin; uses of such novel proteins in therapeutic, diagnostic, and clinical methods; and polynucleotides that encode such novel proteins.... Agent: Lowrie, Lando & Anastasi, LLP

20080182284 - Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes: The invention describes methods for labeling or detecting of immobilized poly(amino acids), including peptides, polypeptides and proteins, on membranes and other solid supports, using fluorescent dipyrrometheneboron difluoride dyes. Such immobilized poly(amino acids) are labeled or detected on blots or on arrays of poly(amino acids), or are attached to immobilized aptamers.... Agent: Invitrogen Corporation C/o Intellevate

20080182285 - Method for measuring animal alpha-amylase: It is an object of the present invention to provide a method capable of measuring a high concentration (up to 2500 U/L) of animal sample without dilutions, which is further capable of specifically measuring α-amylase even in a sample comprising animal α-amylase (EC 3.2.1.1) and glucoamylase (EC 3.2.1.3). The present... Agent: Birch Stewart Kolasch & Birch

20080182286 - Immersion sensor for measuring the concentration of an analyte with the help of an oxide: The invention relates to measuring the concentration of analytes with the aid of an oxidase in an immersion sensor situated in a fluid or in a matrix containing fluid. Oxygen diffuses into the enzyme layer from within, from a gas-filled space connected to the atmosphere and/or to an oxygen reservoir.... Agent: Dorsey & Whitney LLP Intellectual Property Department

20080182287 - Gel formulations and uses thereof: The present invention provides the use of a composition comprising a block polymer as a support matrix in the manipulation, processing or analysis of particles, such as cells and fluorescent beads. In a preferred embodiment, the composition exhibits gel-sol thermoreversibility, micelle formation under gelling conditions, optically compatible, controllable surfactant properties,... Agent: Patrea L. Pabst Pabst Patent Group LLP

20080182288 - High-throughput screen for identifying selective persistent sodium channels channel blockers: A method for identifying a selective persistent Na+ channel blocker by measuring the ability of the blocker to reduce or inhibit a persistent Na+ current to a greater degree than a transient Na+ current. Aspects of the present method provide Na+ depletion/repletion methods for identifying a selective blocker of a... Agent: Allergan, Inc.

20080182289 - High-throughput screen for identifying selective persistent sodium channels channel blockers: A method for identifying a selective persistent Na+ channel blocker by measuring the ability of the blocker to reduce or inhibit a persistent Na+ current to a greater degree than a transient Na+ current. Aspects of the present method provide Na+ depletion/repletion methods for identifying a selective blocker of a... Agent: Allergan, Inc.

20080182290 - Apparatus and methods for determining viability of cell-based products: The invention described herein pertains to an apparatus and methods for testing cell-based products, and more particularly to automated machinery that integrates various functions to determine cell viability at point of care locations.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080182291 - Diagnosis of constipation by analysis of methane concentration: Disclosed are methods of diagnosing constipation and constipation-predominant irritable bowel syndrome by screening for the presence of abnormally high levels of methane and/or methanogenic organisms in a subject.... Agent: Davis Wright Tremaine LLP/los Angeles

20080182292 - Methods and means for influencing intercellular communication and intercellular organelle transport: The invention relates to a method for the investigation of intercellular communication and intercellular transport, wherein after singularisation cells are investigated for membrane tubes which contain F-actin and myosin, have a diameter of 50 to 400 nm, as a rule are up to 50 micrometers long or in same cases... Agent: Birch Stewart Kolasch & Birch

20080182293 - Computerized control of high-throughput transdermal experimental processing and digital analysis of comparative samples: The present invention relates to computer-controlled high-throughput systems, computer-program products, and methods of use to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal transfer, of components in each combination. The methods... Agent: Workman Nydegger

20080182294 - Activatable recombinant neurotoxins: Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.... Agent: Allergan, Inc.

20080182295 - Apparatus and methods for osmotically shocking cells: A method of preparing a recombinant polypeptide of interest includes fermenting a host cell being transformed with a recombinant expression system capable of bringing about secretion of a polypeptide of interest into the periplasm of said host cell. The polypeptide of interest is extracted from the periplasm by applying a... Agent: Trask Britt

20080182296 - Pcr-directed gene synthesis from large number of overlapping oligodeoxyribonucleotides: The present invention provides methods of PCR-directed gene synthesis that may be used for all genes, including those with a high G+C content and/or a long sequence. The invention relates to methods of gene synthesis using overlapping oligonucleotides and polymerase chain reaction (PCR), wherein several PCR parameters, e.g., the concentration... Agent: Fitzpatrick Cella (wyeth)

20080182297 - Medium for the protein-free and serum-free cultivation of cells: A medium is described for the protein-free and serum-free cultivation of cells, especially mammalian cells, whereby the medium contains a proportion of soy hydrolysate.... Agent: Baxter Healthcare Corporation

20080182298 - Method and system for the transformation of molecules,to transform waste into useful substances and energy: The system, based on a recirculating Carbon Flow Loop, neutralizes toxins within municipal waste or other feedstock. A Plasma Syngas Gasifier is used to generate ultra high temperatures in an oxygen controlled atmosphere. This breaks down the feedstock into its basic elements, predominantly hydrogen and carbon monoxide, known as syngas.... Agent: Andrew Day Eric Day

20080182299 - Novel brain natriuretic peptide variants and methods of use thereof: Novel BNP variants. The novel BNP variants according to the present invention may optionally be used for diagnosis of a BNP variant-detectable disease as described herein.... Agent: Staas & Halsey LLP

20080182300 - Methods and compositions for transcription-based nucleic acid amplification: Methods for isothermal exponential amplification of a target polynucleotide are disclosed. The methods employ two transcription modules, the first module providing linear amplification resulting in RNA transcripts, and a second module providing for further (generally cyclical) amplification resulting in more RNA transcripts. In one aspect, the amplification of the first... Agent: Wilson Sonsini Goodrich & Rosati

20080182301 - Microfluidic system for amplifying and detecting polynucleotides in parallel: The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept... Agent: Fish & Richardson P.C.

20080182236 - Asthma susceptibility locus: The present invention describes a susceptibility locus which is functionally related to asthma. The locus maps within human chromosome 7p15-p14. The invention also describes a novel human gene, GPRA. The invention provides diagnostic methods and materials for analysing allelic variation in said locus and the GPRA gene. The invention also... Agent: Birch Stewart Kolasch & Birch

20080182237 - Lung cancer-related nucleic acids: Described are polynucleotides associated with lung cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of lung cancer. Also described are methods that can be used to identify modulators of the disease-associated polynucleotides. Also... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080182270 - Combinatorial artificial receptors including peptide building blocks: R6 can be hydrogen or any suitable blocking or protecting group for an carboxyl-terminal carboxyl group of a peptide. Suitable blocking or protecting groups include those described in Green, T W; Wuts, PGM (1999), Protective Groups in Organic Synthesis Third Edition, Wiley-Interscience, New York, 779 pp. In an embodiment, R6... Agent: Merchant & Gould PC

20080182302 - The gene cluster involved in safracin biosynthesis and its uses for genetic engineering: A gene cluster has open reading frames which encode polypeptides sufficient to direct the synthesis of a safracin molecule.... Agent: King & Spalding

20080182303 - Methods for making simvastatin and intermediates: The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention.... Agent: Verenium C/o Mofo S.d.

20080182304 - Processes for the production of triglycerides of unsaturated fatty acids in the presence of enzymes: Processes for the enzyme-catalyzed production of triglycerides using polyunsaturated fatty acids, in which (a) the reaction of polyunsaturated fatty acids and/or C1-4 alkyl esters thereof with glycerol in vacuo in the presence of an immobilized enzyme to form heir triglycerides is accelerated by addition of an additive from the group... Agent: Cognis Corporation Patent Department

20080182305 - Method of obtaining inorganic salt and acetate salt from cellulosic biomass: A process for obtaining inorganic salt and acetate salt from cellulosic biomass is disclosed. The cellulosic biomass is pretreated by adding one or more than one acid or base to produce a pretreated cellulosic biomass comprising acetic acid or acetate salt. One or more than one base or acid is... Agent: Fitzpatrick Cella Harper & Scinto

20080182306 - Bacillus subtilis mutant strain and a fermentation method for producing acetoin using this organism: The present invention provides a mutant strain of Bacillus subtilis SFA-H31 and includes an optimized method for producing of acetoin using this strain. The advantage of this method to produce acetoin has been defined by its high-yield without mixture with diacetyl or 2,3 butanedinol, both of which are usually accompanied... Agent: Matthias Scholl

20080182307 - Method for preparing para-hydroxystyrene by biocatalytic decarboxylation of para-hydroxycinnamic acid in a biphasic reaction medium: A biocatalytic method for preparing para-hydroxystyrene from para-hydroxycinnamic acid is described. The method uses an enzyme source having para-hydroxycinnamic acid decarboxylase activity to catalyze the decarboxylation of para-hydroxycinnamic acid in a biphasic reaction medium to produce para-hydroxystyrene, which is extracted into the organic phase of the biphasic reaction medium. The... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080182308 - Fermentive production of four carbon alcohols: Methods for the fermentive production of four carbon alcohols is provided. Specifically, butanol, preferably 1-butanol is produced by the fermentive growth of a recombinant bacterium expressing a 1-butanol biosynthetic pathway.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080182309 - Method and apparatus for magnetic fermentation: A method for magnetic fermentation is provided which includes subjecting a biological material in a medium to a static magnetic field in order to affect fermentation of the biological material into a fermented product. The fermentation reaction may occur in an acidic or alkaline medium. The magnetic field may be... Agent: Mckee, Voorhees & Sease, P.L.C

20080182310 - Device and method for rapidly lysing cells or viruses: A cell lysis device for lysing cells or viruses, comprising a cell lysis tube having a sample inlet; a pump connected to the cell lysis tube for transferring a sample into the tube; a sealing unit for reversibly sealing a specific region of the tube; and a laser source for... Agent: Cantor Colburn, LLP

20080182311 - Novel trehalose synthase from picrophilus torridus and methods of use thereof: The present invention relates to the isolation and functional identification of a novel acid and heat resistant trehalose synthase enzyme cloned from Picrophilus torridus. More particularly, the present invention discloses the DNA sequence for the Picrophilus torridus trehalose synthase gene, PTTS, which when expressed in a heterologous host such as... Agent: Catalyst Law Group, Apc

20080182312 - Stable reagents and kits useful in loop-mediated isothermal amplification (lamp): Provided herein is a reagent preparation for loop-mediated isothermal amplification of nucleic acids comprising: at least one polymerase enzyme, a target-specific primer set, and dinucleotide triphosphates (dNTPs) in a single, dry format; wherein said reagent preparation is water soluble and stable above 4° C.... Agent: Morrison & Foerster LLP

20080182313 - Gsk3 polypeptides: The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of... Agent: Novartis Vaccines And Diagnostics Inc.

20080182314 - Neuronal serine threonine protein kinase: The present invention relates to a gene and the coded protein thereof that is involved in the development of sequelae of local ischaemia. The new protein is a serine threonine protein kinase and provides a new therapeutic approach to the prophylaxis and therapy of apoplexy.... Agent: Needle & Rosenberg, P.C.

20080182315 - Novel ion channel-like polypeptide and use thereof: A single polypeptide is disclosed that without the need of any direct ion flow, is capable of converting electrical signals to chemical signals. The polypeptide of at least one embodiment of the present invention can be a novel membrane protein including a specified domain capable of independently functioning as a... Agent: Harness, Dickey & Pierce, P.L.C

20080182317 - Glass fibre compositions: The invention relates to glass fibres having a chemical composition that contains the following constituents in the limits defined hereafter and expressed in percentage by weight, namely: 38 to 49 SiO2; 15 to 25 Al2O3; 1 to 15 CaO; 0 to 4 MgO; 14 to 25 Na2O; 0 to 10... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080182316 - Nucleic acids encoding opiate receptors: The invention provides isolated nucleic acid molecules, host cells that contain an isolated nucleic acid molecule, and substantially pure polypeptides. For example, the invention provides isolated nucleic acid molecules that encode polypeptides having mu3 opiate receptor activity, host cells that contain an isolated nucleic acid molecule that encodes a polypeptide... Agent: Fish & Richardson P.C.

20080182318 - Generation of materials with enhanced hydrogen content from anaerobic microbial consortia including desulfuromonas or clostridia: An isolated microbial consortia is described. The consortia may include a first-bite microbial consortium that converts a starting hydrocarbon that is a complex hydrocarbon into two or more first-bite metabolic products. The consortia may also include a downstream microbial consortium that converts a starting hydrocarbon metabolic product into a downstream... Agent: Townsend And Townsend And Crew, LLP

20080182319 - Methods of obtaining a specific binding member that binds eotaxin: Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralise eotaxin-1 activity. The antibodies VH and/or VL domain of the scFv fragment herein termed CAT-212 and of the IgG4 antibody herein termed CAT 213. One or more complementary determining... Agent: Seed Intellectual Property Law Group PLLC

20080182320 - Two-step immunization procedure against chlamydia infection: A host is immunized against infection by a strain of Chlamydia by initial administration of an attenuated bacteria harbouring a nucleic acid encoding a Chlamydia protein followed by administration of a Chlamydia protein in ISCOMs. This procedure enables a high level of protection to be achieved.... Agent: Sim & Mcburney

20080182321 - Hybrid mushroom strain j9277 and its descendants: A novel hybrid fungus culture, designated J9277, of the mushroom species Agaricus bisporus produces crops of mushrooms having white, rounded, thick-fleshed caps and proportionally long stems in a relatively short interval of time. Diverse additional strains can be developed from J9277 by various means including somatic and tissue culture selection,... Agent: Renner Kenner Greive Bobak Taylor & Weber

20080182322 - Enzymatic degumming utilizing a mixture of pla and plc phospholipases: A method for degumming an oil composition comprises the steps of (a) providing an oil composition containing a quantity of phospholipids, (b) contacting said oil composition simultaneously with one or more phospholipase A enzymes and one or more phospholipase C enzymes, under conditions sufficient for the enzymes to react with... Agent: Jones Day

20080182323 - Enzymatic hydrolysis of biomasses having a high dry matter (dm) content: Disclosed are processes for liquefaction and saccharification of polysacharide containing biomasses having high dry matter content (>20%) and preferably possessing large average particle size. The polysaccharide containing biomasses are subject to enzymatic hydrolysis in a mixer that utilizes “free fall” mixing. “Free fall” mixing provides mechanical degradation of the biomass... Agent: Budde, Schou & Ostenfeld, A/s

20080182324 - Method and reagent system with non-regenerable enzyme-coenzyme complex: The present invention is generally directed towards a reagent system for detecting an analyte in a sample. The reagent system has a detection reagent comprising an enzyme-coenzyme complex in a form such that no regeneration of the coenzyme takes place, whereby the enzyme-coenzyme complex is employed in an at least... Agent: The Law Office Of Jill L. Woodburn, LLC

20080182325 - System including a tunable light and method for using same: The present invention provides a system and method for providing light, which can be used to promote growth of biological material. The light includes a ceramic core, including a catalyst and a containment vessel. Light forms as fuel is ignited within the containment vessel. Use of the ceramic core increases... Agent: Snell & Wilmer L.L.P. (main)

20080182326 - Sulfotransferase 1e1 sequence variants: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are described.... Agent: Fish & Richardson P.C.

20080182327 - Cytotoxin-based biological containment: Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including the E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria... Agent: Knobbe Martens Olson & Bear LLP

20080182328 - Mammalian extraembryonic endoderm cells and methods of isolation: An isolated mammalian extraembryonic endoderm-like cell line is provided. Methods for producing isolated mammalian extraembryonic endoderm-like cell line derived from a mammalian pluripotent stem cell culture are provided. Primate or human embryonic stem cells (ESCs) spontaneously generate the primate or human extraembryonic endoderm-like cell line wherein the extraembryonic endoderm-like cells... Agent: Woodcock Washburn LLP

20080182329 - Methods and products related to metabolic interactions in disease: The invention involves methods of regulating cell growth and division to control disease processes by manipulating mitochondrial metabolism and the expression of cell surface immune proteins. The invention also involves related compositions and screening assays.... Agent: Wolf Greenfield & Sacks, P.C.

20080182330 - Method and apparatus for preparation of genetically transformable plant tissue: A process of mechanical separation of embryos from seeds for genetic transplantation employs counter-rotating cylinders together with one or more culling, hydration, separation, and viability testing steps to provide high-throughput of viable, transplantable tissue.... Agent: Sonnenschein Nath & Rosenthal LLP

20080182331 - Procedure for specific replacement of a copy of a gene present in the recipient genome by the integration of a gene different from that where the integration is made: DNA gene inactivation constructs for homologous recombination in the genome of a mammalian cell are provided.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080182332 - Optimized non-canonical zinc finger proteins: Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC zinc fingers as well as polynucleotides encoding these proteins. Methods of using these proteins for gene editing and gene regulation are also described.... Agent: Robins & Pasternak

20080176206 - Cardiovascular tissue culture substrate: The substrate for culturing a cardiovascular tissue of the present invention is a substrate for culturing a cardiovascular tissue, which is tubular, and comprises a foam comprising a bioabsorbable material reinforced with a reinforcing material comprising a bioabsorbable material, the foam comprising lactide (D, L, DL isomer)-ε-caprolactone copolymer containing lactide... Agent: Brinks Hofer Gilson & Lione

20080176205 - Process and formulation to improve viability of stored cells and tissue: Methods and compositions for the preservation of cells using glucosaminoglycans and derivatives thereof.... Agent: Needle & Rosenberg, P.c.

20080176207 - Stem cell derived factors for treating pathologic conditions: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080176210 - Blood treatment system: A blood treatment system including a computer with a program library containing data sets for the functional processes of blood treatment apparatus. The computer is used to generate data sets with the aid of a catalog of questions to be responded to interactively. In this manner, data sets can be... Agent: Ratnerprestia

20080176209 - Integration of sample storage and sample management for life science: Compositions and methods are disclosed for substantially dry storage at ambient temperatures of biological samples such as nucleic acids and cells in a form from which nucleic acids can be recovered, using a dissolvable or dissociable dry storage matrix that permits recovery of biologically active materials. Compositions and methods are... Agent: Seed Intellectual Property Law Group Pllc

20080176208 - Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light: Methods and apparatuses are provided for reduction of pathogens in fluids containing blood products. Preferred methods include the steps of adding an effective, non-toxic amount of a photosensitizer such as riboflavin to the blood product and exposing the fluid to light having a peak wavelength.... Agent: Gambro Bct, Inc Ip Department

20080176211 - Microfabricated cell sorter: The invention provides a microfabricated device for sorting cells based on a desired characteristic, for example, reporter-labeled cells can be sorted by the presence or level of reporter on the cells. The device includes a chip having a substrate into which is microfabricated at least one analysis unit. Each analysis... Agent: Townsend And Townsend And Crew, LLP

20080176212 - All optical nanoscale sensor: A composition comprising a nanoparticle and at least one adsorbate associated with the nanoparticle, wherein the adsorbate displays at least one chemically responsive optical property. A method comprising associating an adsorbate with a nanoparticle, wherein the nanoparticle comprises a shell surrounding a core material with a lower conductivity than the... Agent: Conley Rose, P.c. David A. Rose

20080176213 - Control of chemical modification: Provided is a method for controlling the degree of labeling (DOL) of a carrier molecule or solid support by the addition of a reactive label competitor to the labeling reaction. When the reactive label competitor is added to the labeling solution the competitor competes with the carrier molecule or solid... Agent: Invitrogen Corporation C/o Intellevate

20080176219 - Assay to detect hcv receptor binding: Identification of HCV receptor target cells using HCV receptor-binding ligands and cell separation by flow cytofluorimetry is described. HCV receptor target cells are employed to conduct assays for HCV receptor-binding ligands in order to identify potential HCV vaccine candidates. HCV receptor target cells are used to measure antibody neutralisation to... Agent: Novartis Vaccines And Diagnostics Inc.

20080176215 - Detection of hpv: The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of... Agent: Casimir Jones, S.c.

20080176214 - Dna for evaluating the progression potential of cervical lesions: The present invention relates to an nucleic acid which is suitable for evaluating the progression potential of cervical lesions, wherein the nucleic acid is obtainable by a process in which RNA from early and late passages of HPV-immortalized cells is isolated and the RNAs characteristic for the early passages and... Agent: Moore & Van Allen Pllc

20080176217 - Method of predicting influenza outbreaks by correlating an increase in replikin count in shrimp white spot syndrome virus and/or taura syndrome virus: The present invention provides a method of predicting outbreaks in influenza virus comprising monitoring concentrations of small peptides having defined structure in influenza viruses, and in particular viral pathogens of shrimp.... Agent: Kenyon & Kenyon LLP

20080176216 - Multifunctional encoded particles for high-throughput analysis: Method for making multifunctional particles. The method includes flowing a first monomer stream loaded with a fluorescent entity along a microfluidic channel and flowing a second monomer stream loaded with a probe adjacent to the first monomer stream along the microfluidic channel. The monomer streams are polymerized to synthesize particles... Agent: Choate, Hall & Stewart LLP

20080176218 - Variants of hepatitis b virus with resistance to anti-viral nucleoside agents and applications thereof: The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral... Agent: Knobbe Martens Olson & Bear LLP

20080176231 - Apoptin-associating proteiins: The invention relates to the field of apoptosis. The invention provides novel therapeutic possibilities, for example novel combinatorial therapies or novel therapeutic compounds that can work alone, sequentially to, or jointly with apoptin, especially in those cases wherein p53 is (partly) non-functional.... Agent: Trask Britt

20080176221 - Assay and compositions for detection of bacillus anthracis nucleic acid: The invention includes compositions and methods of detection of Bacillus anthracis that use oligonucleotide probes specific for genetic material contained in the pXO1 and pXO2 plasmids in nucleic acid hybridization reactions. Embodiments of the method may include additional probes specific for other gene sequences to distinguish B. anthracis from other... Agent: Gen Probe Incorporated

20080176235 - Corn event das-59122-7 and methods for detection thereof: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DAS-59122-7 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and... Agent: Pioneer Hi-bred International, Inc.

20080176245 - Detection of viable agents: A quantitative PCR method has been developed for the simultaneous detection and quantitation of an agent in samples of biologically derived materials. Unlike conventional quantitative PCR detection methods, this assay allows for the detection of viable agents.... Agent: Glaxosmithkline Corporate Intellectual Property - Uw2220

20080176234 - Diagnostics and therapeutics for diseases associated with oxytocin receptor (oxtr): The invention provides a human OXTR which is associated with lung cancer and colon cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of lung cancer and colon cancer.... Agent: Banner & Witcoff, Ltd.

20080176227 - Dna carrier, method of producing the same and collection system using the same: Provided are a DNA carrier where DNA is firmly held in a substrate, which can reduce the elution of DNA into water and can take full advantage of the capability of DNA to selectively and specifically collect a substance; and a method of producing the DNA carrier. Also provided is... Agent: Fitzpatrick Cella Harper & Scinto

20080176229 - Gene expression markers for response to egfr inhibitor drugs: The present invention concerns prognostic markers associated with cancer. In particular, the invention concerns prognostic methods based on the molecular characterization of gene expression in paraffin-embedded, fixed samples of cancer tissue, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR... Agent: Heller Ehrman LLP

20080176243 - Gene regulator: The invention relates to the modulation of gene expression in a cell, also called gene control, in particular in relation to the treatment of a variety of diseases. The invention provides a method for modulating expression of a gene in a cell comprising providing the cell with a signalling molecule... Agent: Trask Britt

20080176239 - Genes associated with schizophrenia: Genes associated with schizophrenia are identified. Methods of screening small molecule compounds for use in treating schizophrenia are described.... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B482

20080176240 - Genes associated with schizophrenia identified using a whole genome scan: Genes associated with schizophrenia are identified. Methods of screening small molecule compounds for use in treating schizophrenia are described.... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B482

20080176236 - Materials and methods for prognosing lung cancer survival: The invention provides methods of prognosing and classifying lung cancer patients into poor survival groups or good survival groups. The invention also includes kits for use in the methods of the invention.... Agent: Bereskin And Parr

20080176225 - Membrane bound reporter gene system: A recombinant DNA construct is provided and includes a first DNA fragment encoding a β-glucuronidase and a second DNA fragment encoding a membrane anchoring domain. The β-glucuronidase may be a human β-glucuronidase or a mouse β-glucuronidase. In one embodiment, an expression vector for delivering a gene of interest or portion... Agent: Patterson & Sheridan, L.l.p.

20080176233 - Method for detecting small oligonucleotides: A method for detecting small oligonucleotides includes providing a biological isolate containing at least one small oligonucleotide. The biological isolate may be contacted with at least one detection oligonucleotide having a label moiety and at least one bridge oligonucleotide under conditions such that the at least one small oligonucleotide and... Agent: Tarolli, Sundheim, Covell & Tummino, LLP

20080176220 - Method, kit and system for enhanced nested pcr: The present invention relates to a method, a kit and a system for sensitive detection of a target nucleic acid molecule. The target nucleic acid molecule may e.g. be specific for a certain microorganism, e.g. a pathogenic microorganism such as B. anthracis. The methods and kits relate to so-called nested... Agent: Knobbe Martens Olson & Bear LLP

20080176223 - Methods and compositions for modulating telomerase reverse transcriptase (tert) expression: Nucleic acid compositions comprising a region and a TERT minimal promoter activator binding site that acts to activate transcription of the telomerase reverse transcriptase (TERT) coding sequence, as well as vectors and constructs including the same, are provided. Also provided are methods of modulating, e.g., inhibiting, the TERT transcription activation... Agent: Bozicevic, Field & Francis LLP

20080176226 - Methods and kits for the detection of nucleotide mutations using peptide nucleic acid as both pcr clamp and sensor probe: Disclosed herein is a method for determining whether a target polynucleotide sequence contained in a nucleic acid sample has nucleotide variation(s) in a selected region thereof, the steps of which involve the use of a pair of primers that allows the formation of a PCR product having a sequence covering... Agent: Hunton & Williams LLP Intellectual Property Department

20080176224 - Methods for identifying a patient as a candidate for treatment with a long acting beta agonist and for predicting a patient's response to long acting beta2 agonist therapy by analysing polymorphisms in the beta2-adrenergic receptor gene: A method for identifying a patient as a candidate for treatment with a long acting beta agonist comprises isolating a biological sample from a patient and identifying the presence or absence of at least one haplotype C. The presence of at least one haplotype C in a patient sample indicates... Agent: Fish & Richardson P.c.

20080176241 - Mitigation of photodamage in analytical reactions: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage... Agent: Morgan, Lewis & Bockius LLP (sf)

20080176237 - Non-invasive prenatal genetic screen: The present invention provides methods and kits useful for genetic testing or screening of fetuses using nucleic acid samples isolated from cervical mucus samples of fetus hosts.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080176228 - Nucleic acid enzyme biosensors for ions: Disclosed are compositions and methods for the sensitive and selective detection of ions using nucleic acid enzymes.... Agent: Evan Law Group Llc

20080176238 - Plant farnesyltransferases: This invention relates to an isolated nucleic acid fragment encoding a farnesyltransferase subunit. The invention also relates to the construction of a chimeric gene encoding all or a portion of the farnesyltransferase subunit, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080176232 - Reaction system for performing in the amplification of nucleic acids: A method of carrying out an amplification reaction, said method comprising supplying to a well in a disposable unit (a) a sample which contains or is suspected of containing a target nucleic acid sequence (b) primers, nucleotides and enzymes required to effect said amplification reaction and (c) a buffer system,... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20080176230 - Systems and methods for real-time pcr: In one aspect, the present invention provides a systems and methods for the real-time amplification and analysis of a sample of DNA.... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080176242 - Two stage nucleic acid amplification using an amplification oligomer: This invention provides methods, compositions and systems to detect a nucleic acid of interest in a two-stage amplification. The two-stage amplification begins with a first non-enzymatic accumulation of an amplification oligomer that is the target substrate for a second nucleic acid amplification or assay. Two or more amplification oligomers can... Agent: Quine Intellectual Property Law Group, P.c.

20080176244 - Usage of exocyst complex component or sec3 or its homolog in delivery of exogenous molecules in transit: The invention relates to the usage of Exocyst complex component or Sec3 or its homolog as a molecular marker for monitoring an exogenous molecule like nucleic acid in transit and optimizing the delivery of the exogenous molecule to a cell. Delivery of the molecule is monitored by detecting expression of... Agent: Birch Stewart Kolasch & Birch

20080176246 - Multiplex protein fractionation: The invention provides methods, compositions, and kits for multiplex fractionation of proteins in a sample. Protein-binding molecules, such as small epitope antibodies or small epitope aptamers, are used for multiplex fractionation of proteins in a protein containing sample. Detection of fractionated proteins may be used for characterization of proteins in... Agent: Morrison & Foerster LLP

20080176247 - Trimeric collagen scaffold antibodies: A collagen scaffold domain, including a collagenous or collagen-like domain, which directs self-trimerization is provided. The collagen scaffold domain can be fused to one or more heterologous domains, such as an antibody domain. Methods for generating and using the scaffold domains and fusion proteins are also provided.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080176248 - Phage display affinity and specificity filters and forward screen: The invention provides an affinity filter for the binding of phage-displayed proteins to dissolved target molecules. The phage-displayed proteins are contacted with immobilized target in the presence and absence of dissolved target; the behavior of the phage-displayed proteins as a function of concentration of dissolved target permits approximation of the... Agent: Jones Day

20080176254 - Affinity separation compositions and methods: The present invention provides compositions and methods for affinity separation of targets from mixtures. In particular, disclosed are avian IgY antibodies coupled to solid supports and their methods of use.... Agent: Perkins Coie LLP

20080176252 - Amyloid beta-derived diffusible ligands (addls), addl-surrogates, addl-binding molecules, and uses thereof: The invention herein comprises amyloid beta-derived diffusible ligands (ADDLs), compositions comprising ADDLs, ADDL-surrogates, ADDL-binding molecules, and methods of using any of the foregoing compounds and compositions. ADDLs comprise amyloid β protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of... Agent: Jane Massey Licata, Esquire Licata & Tyrrell P.c.

20080176253 - Detecting human or animal immunoglobin-e: Methods, systems, and apparatus for detecting the presence of human or animal immunoglobin-E are described. A fluid or gas sample may pass through a particle-based detection system of a cartridge. Detection and analysis techniques may be applied to determine the identity and quantity of the captured IgE.... Agent: Fulbright & Jaworski L.l.p.

20080176255 - Mold detection composition and methods: This invention relates to compositions and methods for the detection of mold. Specifically, provided herein are compositions and methods for the detection of mold by detecting differences in light intensity of fluoresence resulting from interaction between the mold and the compositions described herein.... Agent: Pearl Cohen Zedek Latzer, LLP

20080176249 - Gfp-snap25 fluorescence release assay for botulinum toxin protease activity: The present invention provides a nucleic acid molecule which contains a nucleotide sequence encoding a SNAP-25 substrate which includes (i) a green fluorescent protein; (ii) a first partner of an affinity couple; and (iii) a portion of SNAP-25 that includes a BoNT/A, BoNT/C1 or BoNT/E recognition sequence containing a cleavage... Agent: Allergen, Inc. (t2-7h)

20080176250 - Method of testing for atp load in commercial laundry and for data tracking the results: A method of testing for sanitization of textiles comprises the steps of cleaning textiles in a water solution and testing the water solution for the presence of contaminants such as adenosine triphosphate (ATP), typically with a luminometer. Typically, the water solution will be drained from a cleaning vessel and tested.... Agent: Sand & Sebolt

20080176251 - Preparation of high purity phenothiazine n-alkylsulfonates and their use in chemiluminescent assays for the measurement of peroxidase acitivity: A process is described for preparing, efficiently and with a high degree of purity N-alkylsulfonates of phenothiazine. The process consists in (a) the preparation of the phenothiazine anion, and (b) the reaction of said anion with cyclic alkyl sulfonates, such as 1,3-propane sultone and 1,4-butane sultone. This process is simpler,... Agent: Nixon & Vanderhye, Pc

20080176256 - Method for detecting prp using at least one positive charge and/or at least one glycosidic bond and a ligand other than a protein ligand: The invention relates to a method for detecting PrP in a biological human or animal sample that may contain PrP. The inventive method is characterised in that it uses a molecule containing at least one positive charge and/or at least one osidic bond and a ligand other than a proteinic... Agent: Oliff & Berridge, Plc

20080176258 - Soluble form of carbonic anhydrase ix (s-ca ix), assays to detect s-ca ix, ca ix's coexpression with her-2/neu/c-erbb-2, and ca ix-specific monoclonal antibodies to non-immunodominant epitopes: Disclosed herein among other MN/CA IX-related inventions are new MN/CA IX-specific antibodies generated from MN/CA IX-deficient mice, preferably monoclonal antibodies and immunoreactive fragments and engineered variants thereof. Subsets of the new antibodies are to either the proteoglycan-like (PG) domain or to the carbonic anhydrase (CA) domain of MN/CA IX, and... Agent: Leona L. Lauder

20080176259 - Uses of carbamoyl phosphate synthetase 1 (cps 1) and it's fragments for the diagnosis of liver diseases: Use of carbamoyl phosphate synthetase 1 (CPS 1) and/or of fragments of the N-terminal part of CPS 1 from body fluids or body tissues as marker peptides for the diagnosis and for the prognosis and the monitoring of inflammations and infections, including sepsis, and of liver failure as part of... Agent: Kathy Smith Dias, Esq. Heslin Rothenberg Farley & Mesiti P.c.

20080176260 - Method of testing for atp load in commercial laundry and for data tracking the results: A method of testing for sanitization of textiles comprises the steps of cleaning textiles in a water solution and testing the water solution for the presence of contaminants such as adenosine triphosphate (ATP), typically with a luminometer. Typically, the water solution will be drained from a cleaning vessel and tested.... Agent: Sand & Sebolt

20080176261 - Colorimetric substrate and methods for detecting poly(adp-ribose) polymerase activity including parp enzymes parp-1, vparp, and tankyrase-1: Disclosed are compositions and methods capable of facilitating the detection and measurement of poly(ADP-ribose)polymerases (PARP enzymes). PARP enzyme activity can be monitored using a novel calorimetric substrate, ADP-ribose-para-nitrophenol. The substrate can be synthesized from beta nicotinamide adenine dinucleotide (β-NAD+) and para-nitrophenol. In an embodiment, a continuous assay was developed to... Agent: Greenlee Winner And Sullivan P C

20080176263 - Materials and methods for efficient and accurate detection of analytes: The present invention provides diagnostic methods and devices that can be used to assay a medium, such as tissue in vivo or a sample in vitro (e.g. biological sample or environmental sample), in order to determine the presence, quantity, and/or concentration ratio of one or more target analytes.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080176262 - Wound dressing: A dressing for wounds includes a useful material, such as dye or biocide, trapped within or behind a gelatin barrier. On application to a wound, metalloproteinases naturally present in the wound diffuse into the dressing and degrade the gelatin, releasing the trapped material. The released material serves various useful purposes,... Agent: Susan L. Parulski Patent Legal Staff

20080176272 - Assay device and method: A device and method for the separation of a component in a liquid sample prior to the detection of an analyte in said sample, wherein a sample is added to a receiving zone on a substrate, said substrate further optionally comprising a reaction zone, a transport or incubation zone connecting... Agent: Morrison & Foerster LLP

20080176265 - Biofilm preparation using potassium permanganate: A method for preparing a biofilm includes the steps of rinsing the biofilm. There is the step of staining the biofilm with potassium permanganate and water.... Agent: Ansel M. Schwartz Attorney At Law

20080176266 - Biomarkers of metabolic responses to hepatotoxicants and carcinogens: Methods for the measurement and prediction of response to hepatotoxicants and carcinogens through the detection of metabolites in a mammal are provided. The metabolites can be used as biomarkers, including efficacy biomarkers, surrogate biomarkers, and toxicity biomarkers. The methods find use for early prediction of toxicity, target identification/validation, and monitoring... Agent: Hutchison Law Group Pllc

20080176269 - Method for determination of dht levels in tissue samples: Provided is a method for determining the presence or amount of 5-α-dihydro-3-keto steroids (ADKSs) comprising the steps of preparing a sample for chromatographic separation, subjecting the sample to chromatographic separation, subjecting the chromatographically separated sample to atmospheric pressure photoionization (APPI), and detecting the amount of alkylated parent ions using mass... Agent: Hodgson Russ LLP The Guaranty Building

20080176267 - Method for obtaining primary culture tumour cells from tumour tissue, in particular breast carcinoma, primary-culture tumour cells and their use: The present invention relates to methods for obtaining primary-culture tumour cells from tumour tissue. More precisely, the present invention relates to a method for obtaining primary-culture tumour cells from tumour tissue, in particular breast carcinoma, where, in one method step, the tumour tissue is divided into tumour-tissue sections of a... Agent: Whitham, Curtis & Christofferson & Cook, P.c.

20080176268 - Mn gene and protein: Herein disclosed is a novel oncogene named MN or alternatively MN/CA IX. Abnormal expression of the MN gene is shown to signify oncogenesis, and diagnostic/prognostic methods for pre-neoplastic/neoplastic disease to detect or detect and quantitate such abnormal MN gene expression. Also disclosed are methods to treat pre-neoplastic/neoplastic disease involving the... Agent: Leona L. Lauder

20080176264 - Osteoclast culture vessels and methods of use: Osteoclast culture vessels comprising and adherent layer of bone particles for detecting osteoclast function.... Agent: Banner & Witcoff, Ltd.

20080176271 - Sensors for detecting substances indicative of stroke, ischemia, infection or inflammation: A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction... Agent: Knobbe Martens Olson & Bear LLP

20080176270 - Use of cross-protection to identify novel vaccine candidates for infectious agents: This invention discloses methods for identifying Francisella tularensis vaccine candidates. It enables identification of novel vaccine candidates and quality assurance for vaccine batches, assessment of protection in vaccinates and identification of the infecting agent in vaccinates. Mice were first vaccinated with Brucella abortus O-polysaccharide (OPS) vaccine. These animals were then... Agent: Nixon & Vanderhye, Pc

20080176273 - Optical method and device for the detection and enumeration of microorganisms: A new device and method for detecting the presence of living microorganisms in test samples are described. The device comprises a container with at least one section transparent to light, a growth zone located in said container containing a mixture of growth media capable of supporting growth of the microorganisms,... Agent: John R. Benefiel

20080176274 - Method of classifying and counting leucocytes: n

20080176276 - Cell observation apparatus, cell observation method, and program product: A cell observation apparatus includes a cell recognition unit that recognizes a cellular region representing a cell from cell image data acquired by imaging the cell at a plurality of time points; and a cell parameter measurement unit that measures cell parameters characteristic of the cellular region recognized by the... Agent: Scully Scott Murphy & Presser, Pc

20080176275 - Method for isolating a part of a layer of a biological material: A film with a tissue section is placed with the tissue section downward on a microscope slide and the microscope slide positioned in the object plane of an inverse microscope; where an adhesive tape is arranged, with a bonding agent downward, above the film and therefore above the tissue section;... Agent: Henry M. Feiereisen Henry M. Feiereisen, Llc

20080176277 - Expanding the eukaryotic genetic code: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic... Agent: Quine Intellectual Property Law Group, P.c.

20080176282 - Bgl5 beta-glucosidase and nucleic acids encoding the same: The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl5, and the corresponding BGL5 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL5, recombinant BGL5 proteins and methods for producing the same.... Agent: Genencor International, Inc. Attention: Legal Department

20080176280 - Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel ecdysone receptor/chimeric retinoid X receptor-based inducible gene expression system and methods of modulating gene expression in a host cell for applications... Agent: Sughrue Mion, Pllc

20080176285 - Glcnac phosphotransferase of the lysosomal targeting pathway: The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080176279 - Human cyclin-dependent kinase (hpnqalre): A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for treating proliferative disorders and neoplasia are also provided.... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20080176281 - Secreted proteins and uses thereof: The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further... Agent: Millennium Pharmaceuticals, Inc.

20080176284 - Site specific incorporation of keto amino acids into proteins: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids... Agent: Quine Intellectual Property Law Group, P.c.

20080176283 - Thermotoga neapolitana dsm 5068 alkaline phosphatase (phoa) gene and recombinant enzyme production: The present invention relates to compositions and methods for providing a recombinant thermostable Thermotoga neapolitana alkaline phosphatase enzyme. More particularly, the invention relates to engineering Escherichia coli with T. neapolitana alkaline phosphatase gene expression vectors for providing an inducible system for thermostable enzyme production, wherein the expressed enzyme is readily... Agent: Medlen & Carroll, LLP

20080176278 - Two helix binders: Provided herein are isolated polypeptides derived from the staphylococcal protein A protein B domain comprising a pair of anti-parallel alpha helices that are capable of binding a target. Also provided are nucleic acid sequences encoding such two helix binders, vectors containing the nucleic acid sequences encoding for two helix binders,... Agent: General Electric Company Global Research

20080176287 - Highly phosphorylated and sulfated recombinant factor ix: The present invention relates to a purified recombinant blood coagulation factor IX (rFIX) preparation, wherein at least 25% of the rFIX in the preparation is fully phosphorylated and sulfated, a cell culture expressing a rFIX resulting in said preparation, a pharmaceutical composition for treating a bleeding disorder comprising said preparation,... Agent: Baxter Healthcare Corporation

20080176286 - Method for making monoclonal antibodies and cross-reactive antibodies obtainanble by the method: A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically cross-react with two or more different receptors to which Apo-2 ligand (Apo-2L) can bind.... Agent: Genentech, Inc.

20080176288 - Recombinant production of polyanionic polymers, and uses thereof: A polyanionic polymer can improve the bioactivity and water-solubility properties of a drug to which it is joined. The inventive method provides a monodispersed preparation of a recombinantly-produced polyanionic polymer that can be easily manipulated, such as lengthened. An active moiety may be chemically or recombinantly joined to a polyanionic... Agent: Foley And Lardner LLP Suite 500

20080176290 - Apparatus for high throughput chemical reactions: Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise addressable units that can be addressed according to the temperature of the reaction to be run. The subject apparatus, systems, and chips are particularly suited for performing... Agent: Wilson Sonsini Goodrich & Rosati

20080176291 - Methods and compositions for selectively cleaving dna containing duplex nucleic acids in a complex nucleic acid mixture, and nuclease compositions for use in practicing the same: Methods of selectively cleaving DNA containing duplex nucleic acids in a complex nucleic acid mixture, as well as nuclease containing compositions for use therein, are provided. In the subject methods, a nuclease or composition thereof is employed to provide for selective cleavage of DNA containing duplex nucleic acids in a... Agent: Bozicevic, Field & Francis LLP

20080176292 - Portable buoyancy driven pcr thermocycler: A closed loop convective flow thermocycler for amplifying DNA sequences via polymerase chain reaction establishes buoyancy driven flow in response to an applied temperature gradient, so that PCR reagents are continuously cycled among temperature zones corresponding to denaturing, annealing and extension temperatures.... Agent: Conley Rose, P.c. David A. Rose

20080176293 - Rna-dependent rna polymerase, methods and kits for the amplification and/or labelling of rna: The invention relates to an RNA-dependent RNA-polymerase, to methods and kits for marking and/or amplifying in a primary dependent or independent manner a ribonucleic acid (RNA), in particular a viral, eucaryontic, procaryontic and double-stranded ribonucleic acid (RNA) for the biological and medical use thereof. Said RNA-dependent RNA-polymerase comprises a right-hand... Agent: St. Onge Steward Johnston & Reens, Llc

20080176289 - System and method for rapid thermal cycling: At least one exemplary embodiment is directed to an apparatus that includes a microfluidic channel and at least one energy absorbing element, where the energy absorbing element is configured to absorb at least a portion of an incident electromagnetic radiation. The absorption of the radiation by the energy absorbing element... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080176294 - Method for amplification of rna sequences: The invention relates to a method for amplification of a target RNA sequence, wherein the first primer comprises a hybridizing sequence of 7 to 14 nucleotides, which is capable of binding to a first segment of the target RNA sequence, a transcription enhancing sequence, and an anchor which is capable... Agent: Myers Bigel Sibley & Sajovec

20080176222 - Multiplex pcr for the detection of ampc beta-lactamase genes: Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain AmpC beta-lactamases. The primers can be employed in methods to detect the presence or absence of an AmpC beta-lactamase gene in samples, and to identify nucleic acid characteristic of AmpC beta-lactamase genes in samples, particularly, in clinical... Agent: Mueting, Raasch & Gebhardt, P.a.

20080176257 - Assay for antibodies: The presence and quantity of an antibody of interest in a patient's bloodstream or other biological sample can serve as an important clinical or other analytical or diagnostic tool. ELISA methods, and kits for such assays, as well as anti-idiotypic antibodies and hybridomas producing them, are developed to detect levels... Agent: Genentech, Inc.

20080176295 - Pef-ts expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP

20080176296 - Gene coding for glucose-6-phosphate-dehydrogenase proteins: The present invention relates to isolated nucleic acid molecules encoding mutants of glucose-6-phosphate dehydrogenase, and vectors and hosts cells including such nucleic acid molecules. These nucleic acid molecules are involved in the biosynthesis of a fine chemical, e.g., an amino acid such as lysine. The present invention also relates to... Agent: Lahive & Cockfield, LLP

20080176297 - Gene rcs 21: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, Pc

20080176298 - Oil recovery from dry corn milling ethanol production processes: A corn oil extraction process is disclosed. The process includes the recovery of corn oil and other co-products, including but not limited to steam, electric power and chemicals, from an ethanol production process and in particular, a process that involves dry corn milling methods. The process involves extraction of oil... Agent: Dorsey & Whitney LLP Intellectual Property Department

20080176299 - Production of peracids using an enzyme having perhydrolysis activity: A process is provided for producing peroxycarboxylic acids from carboxylic acid esters. More specifically, carboxylic acid esters are reacted with an inorganic peroxide, such as hydrogen peroxide, in the presence of an enzyme catalyst having perhydrolysis activity. The present perhydrolase catalysts are classified as members of the carbohydrate esterase family... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080176300 - Microbial conversion of sugar acids and means therein: A DNA molecule comprising a fungal gene encoding an enzyme protein capable of converting L-galactonic acid into L-threo-3-deoxy-hexulosonic acid has been cloned and heterologously expressed. The enzyme is involved in the metabolic conversion of sugar acids, which are present in biological waste material such as sugar beet pulp and other... Agent: Banner & Witcoff, Ltd.

20080176301 - Hydrogen processing, and impurity removal and cleaning methods in a biomass conversion process: In one embodiment, the disclosure includes a method of biomass conversion including fermenting biomass to produce a carboxylic acid or carboxylate salt and hydrogen gas, recovering the hydrogen gas, and converting the carboxylic acid or carboxylate salt to an alcohol using the hydrogen gas. In one embodiment, the hydrogen produced... Agent: Baker Botts L.l.p. Patent Department

20080176302 - Process for the biological production of 1,3-propanediol with high yield: The present invention provides a microorganism useful for biologically producing 1,3-propanediol from a fermentable carbon source at higher yield than was previously known. The complexity of the cofactor requirements necessitates the use of a whole cell catalyst for an industrial process that utilizes this reaction sequence to produce 1,3-propanediol. The... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080176303 - Farm scale ethanol plant: An energy-efficient cycle for the production of ethanol and optionally natural gas from sunlight and biomass comprising first producing or obtaining biomass, for example by planting and harvesting of either an annual or perennial crop or both, and optionally tilling, fertilizing and obtaining wood wastes or paper wastes on-site or... Agent: Bromberg & Sunstein LLP

20080176304 - Designer organisms for photosynthetic production of ethanol from carbon dioxide and water: The present invention provides a revolutionary photosynthetic ethanol production technology based on designer transgenic plants, algae, or plant cells. The designer plants, designer algae, and designer plant cells are created such that the endogenous photosynthesis regulation mechanism is tamed, and the reducing power (NADPH) and energy (ATP) acquired from the... Agent: Scully Scott Murphy & Presser Pc

20080176305 - Functional composition: A functional composition containing as an active ingredient a lactic acid fermented product obtained by fermenting a component of soybean origin using a lactic acid bacterium belonging to the genera Lactobacillus, Leuconostoc, or Pediococcus. It has various activities such as growth hormone secretagogue activity, fatigue accumulation preventing activity, circadian rhythm... Agent: Young & Thompson

20080176306 - Methods for sterilizing biological materials: Methods are disclosed for sterilizing biological products to reduce the level of active biological contaminants such as viruses, bacteria, yeasts, molds, mycoplasmas and parasites.... Agent: Morgan Lewis & Bockius LLP

20080176307 - Method of isolating cell or sample to be analyzed in cell: There is disclosed a method of irradiating a specimen which is laid on a substrate and which includes a cell with a laser beam to remove an unnecessary specimen portion other than a cell portion from the substrate, next inserting the cell portion into one opening in a cylindrical member... Agent: Frishauf, Holtz, Goodman & Chick, Pc

20080176308 - Heterodimers and methods of using them: Novel heterodimers of tetrahydroacridines and tetrahydroquinolinones are disclosed. The heterodimers are capable of acting as both acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists. The heterodimers may be used to improve cognitive defects via treatment or prevention in both humans and non-humans.... Agent: Heslin Rothenberg Farley & Mesiti Pc

20080176309 - Inhibition of shp2/ptpn11 protein tyrosine phosphatase by nsc-87877, nsc-117199 and their analogs: Compounds and associated methods for inhibiting a protein tyrosine phosphatase. By a combination of experimental and virtual screenings of the NCI Diversity Set chemical library, NSC-87877 and NSC-117199 have been identified as Shp2 PTP inhibitors. Significantly, NSC-87877 is active in cell-based assays and has no detectable off-target effects in the... Agent: Smith Hopen, Pa

20080176310 - Soluble form of carbonic anhydrase ix (s-ca ix), assays to detect s-ca ix, ca ix's coexpression with her-2/neu/c-erbb-2, and ca ix-specific monoclonal antibodies to non-immunodominant epitopes: Disclosed herein is the discovery of a soluble MN/CA IX (s-CA IX) in body fluids, such as, urine and serum. Said s-CA IX comprises the extracellular domain of CA IX or portions thereof. The predominant s-CA IX species is the extracellular domain comprising a proteoglycan-like (PG) domain and carbonic anhydrase... Agent: Leona L. Lauder

20080176311 - Methods and compositions for transcription-based nucleic acid amplification: Methods for isothermal exponential amplification of a target polynucleotide are disclosed. The methods employ two transcription modules, the first module providing linear amplification resulting in RNA transcripts, and a second module providing for further (generally cyclical) amplification resulting in more RNA transcripts. In one aspect, the amplification of the first... Agent: Wilson Sonsini Goodrich & Rosati

20080176312 - Composition exhibiting a von willebrand factor (vwf) protease activity comprising a polypeptide chain with the amino acid sequence aaggilhlellv: The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV, vWF cleaving complexes and methods for their production.... Agent: Baxter Healthcare Corporation

20080176313 - Multiply-substituted protease variants: Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino... Agent: Genencor International, Inc. Attention: Legal Department

20080176314 - Apparatus for perforating membrane: A method of perforating a membrane 10 and apparatus therefore is presented. The method comprises: bringing a membrane-denaturing substance into contact with or close proximity to at least a site of said membrane 10, said substance inducing a membrane-denaturing reaction by a stimulus; providing said stimulus to said substance so... Agent: Christensen, O'connor, Johnson, Kindness, Pllc

20080176315 - Apparatus for temporal immersion culture of cells: The present invention provides an apparatus for temporal immersion cell culture comprising: A first container for holding culture media; A second container for holding the culturing cells; At least, one tube that connects a port in the first container to a port in the second container; and, A mechanism to... Agent: John J. Martinez Md. Jd.

20080176316 - Mitigation of photodamage in analytical reactions: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage... Agent: Morgan, Lewis & Bockius LLP (sf)

20080176317 - System and device for transformation and detection of substances: A system and method for transformation of at least one harmful analyte that is difficult to detect to a substance or substances that are more readily detectable by a detector unit and includes parts and steps for detection and quantification of a target analyte or a plurality of analytes. The... Agent: Bradley D. Goldizen

20080176318 - Highly efficient devices and methods for culturing cells: This invention relates to methods and devices that improve cell culture efficiency. They include the use of gas permeable culture compartments that reduce the use of space while maintaining uniform culture conditions, and are more suitable for automated liquid handling. They include the integration of gas permeable materials into the... Agent: Patterson, Thuente, Skaar & Christensen, P.a.

20080176319 - Methods and compositions for modulating apoptotic pathways: The present invention relates to methods, compositions and systems for modulating apoptotic pathways. In particular, the present invention relates to methods, compositions and systems for inducing apoptosis in cancer cells. The present invention further relates to methods, compositions and systems for identifying drugs that modulate apoptotic pathways.... Agent: Peter G. Carroll Medlen & Carroll, LLP

20080176320 - Selective lysis of sperm cells: The teaching provides a method for selectively lysing sperm cells in a mixed cell sample, particularly in the field of forensic sciences. Reagents and kits for carrying out the methods are also provided.... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080176321 - Survivin-binding proteins, encoding nucleic acids, and methods of use: In accordance with the present invention, there are provided novel Survivin-binding-proteins (SBPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SBPs can be employed in a variety of ways, for example, for the production of anti-SBP antibodies thereto, in therapeutic compositions and in... Agent: Mcdermott, Will & Emery

20080176322 - Nucleic acids and proteins of insect or83b odorant receptor genes and uses thereof: The present invention relates to insect odorant receptor genes and methods for identifying odorant receptor genes. The invention provides nucleotide sequences of insect odorant receptor genes Or83b, amino acid sequences of their encoded proteins (including peptides or polypeptides), and related products and methods. The nucleic acids of the invention may... Agent: Norman D. Hanson Fulbright & Jaworski L.l.p.

20080176323 - Polynucleotides encoding e38n interferon gamma polypeptides: A conjugate exhibiting interferon gamma activity and comprising at least one first non-polypeptide moiety covalently linked to an IFG polypeptide, the polypeptide comprising an amino acid sequence that differs from that of a parent IFNG polypeptide in at least one introduced and/or at least one removed amino acid residue comprising... Agent: Maxygen, Inc. Intellectual Property Department

20080176324 - In vitro maturation of immature human oocytes: The invention provides methods for in vitro maturation of immature human oocytes. In one aspect, the invention provides a method for in vitro maturation of immature human oocytes, comprising the steps of: (a) inducing in a female human subject an increase in endogenous luteinizing hormone levels, said subject having not... Agent: Woodcock Washburn LLP

20080176325 - Method for obtaining and storing multipotent stem cells: The invention provides an isolated tissue comprising a source of millions of postnatal stem cells expressing embryonic stem cell markers, and a method of storing or banking such isolated tissue to provide stems cells for later therapeutic use for the donor or for allogeneic transplant with donor permission.... Agent: Maginot, Moore & Beck, LLP Chase Tower

20080176326 - Delivery of high cell mass in a syringe and related methods of cryopreserving cells: This invention relates to methods and apparatus for cryopreserving biological materials for extended periods of time. In an exemplary embodiment, the method comprises suspending biological materials in a cryosolution, freezing the biological materials in the apparatus, and removing the frozen biological materials from the apparatus to thaw them for use.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080176327 - Method for the evolutionary design of biochemical reaction networks: The present invention relates to methods for achieving an optimal function of a biochemical reaction network. The methods can be performed in silico using a reconstruction of a biochemical reaction network of a cell and iterative optimization procedures. The methods can further include laboratory culturing steps to confirm and possibly... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper Us LLP

20080176328 - Method of inducing differentiation of mesenchymal stem cells into neurons: The present invention relates to a method for inducing differentiation of bone marrow-derived mesenchymal stem cells into mature neurons by culturing them in an optimal medium supplemented with necessary composition. According to the pre-induction method of the invention and a method for inducing differentiation of mesenchymal stem cells into neurons... Agent: Jhk Law

20080176329 - Methods for generating hypermutable yeast: Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast cells with the defective mismatch repair system are hypermutable, but after selection of desired mutant yeast strains, they can be rendered genetically stable... Agent: Banner & Witcoff, Ltd.

20080171312 - Methods for identifying and analyzing biomarkers from plasma-derived microparticles: The present invention provides methods for identifying candidate biomarkers in the plasma microparticle proteome. It also provides methods for isolating, identifying, and analyzing microparticles derived from plasma, particularly platelet-poor plasma.... Agent: Feldmangale, P.A.

20080171314 - Method for controlling the microbiological quality of an aqueous medium and kit therefor: Disclosed is a method for controlling the microbiological quality of an environmental aqueous medium, suspected of containing various micro-organisms, having the following steps: selecting a reference set, having at least three micro-organisms, representing jointly or separately a microbiological quality level; providing a microbiological detection kit, having at least three probes... Agent: Oliff & Berridge, PLC

20080171313 - Viral variants: The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus variants exhibiting complete or partial resistance to nucleoside analogues and/or reduced interactivity with antibodies to viral surface components including... Agent: Nixon & Vanderhye, PC

20080171333 - Corn event das-59122-7 and methods for detection thereof: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DAS-59122-7 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and... Agent: Pioneer Hi-bred International, Inc.

20080171334 - Corn event das-59122-7 and methods for detection thereof: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DAS-59122-7 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and... Agent: Pioneer Hi-bred International, Inc.

20080171332 - Cystic fibrosis transmembrane conductance regulator gene mutations: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further... Agent: Foley & Lardner LLP

20080171330 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the... Agent: Nixon Peabody LLP - Patent Group

20080171318 - Epigenetic methods and nucleic acids for the detection of lung cell proliferative disorders: The invention provides methods, nucleic acids and kits for detecting, classifying and/or distinguishing between or among lung cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and... Agent: Davis Wright Tremaine, LLP/seattle

20080171329 - Gel microdrops in genetic analysis: The invention provides methods of nucleic acid analysis. Such methods entail forming a population of gel microdrops encapsulating a population of biological entities, each entity comprising a nucleic acid, whereby at least some microdrops in the population each encapsulate a single entity. The population of gel microdrops is then contacted... Agent: Townsend And Townsend And Crew, LLP

20080171323 - Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections: The present invention includes compositions, systems and methods for the early detection and consistent determination of the extent, type and nature of a host immune response and the nature of the infectious disease using gene expression data.... Agent: Chalker Flores, LLP

20080171315 - Homogeneous assay system: A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification, assay.... Agent: Roche Molecular Systems, Inc. Patent Law Department

20080171325 - Method and device for detecting the presence of a single target nucleic acid in a sample: A method comprising loading a sample portion into a sample chamber inside a microcapillary device, subjecting the sample portion to at least a first amplification step, and then determining whether the first sample portion contains at least one molecule of a target nucleic acid. Also, a microfluidic device comprising a... Agent: Burr & Brown

20080171326 - Method and device for detecting the presence of a single target nucleic acid in a sample: A method comprising depositing a sample portion in a sample retaining means, and forcing a curable fluid across an exposed surface of the sample retaining means, thereby displacing excess first sample from the exposed surface without displacing the sample from the sample retaining means. Also, a method comprising depositing a... Agent: Burr & Brown

20080171327 - Method and device for detecting the presence of a single target nucleic acid in a sample: A method comprising subjecting one or more sample portion(s) to a single amplification step, thereby amplifying a single molecule in the sample portion to a detectable level, and, in some embodiments, then determining whether the sample portion contains at least one molecule of the target nucleic acid. In some embodiments,... Agent: Burr & Brown

20080171335 - Method for personalized diet design: The invention provides methods and kits for designing a diet with a desired fat content for an individual in need thereof to allow the individual to, for example, maintain or reduce healthy weight, manage diabetes, for example by managing weight or accommodate a food allergy. The method comprises determining whether... Agent: David S. Resnick

20080171324 - Method for quantifying number of molecules of target nucleic acid contained in a sample: A method comprises loading one or more sample portions into respective sample chambers, subjecting each of the sample portions to an amplification step, for each sample portion, determining whether the sample portion contains at least one molecule of a target nucleic acid; and then quantifying a number of the sample... Agent: Burr & Brown

20080171331 - Methods and compositions for large-scale analysis of nucleic acids using dna deletions: The present invention is related generally to analysis of polynucleotides, particularly polynucleotides derived from genomic DNA. The invention provides methods, compositions and systems for such analysis. Encompassed by the invention are constructs that include pairs of target sequences which are separated by a known distance in the polynucleotide from which... Agent: Morgan, Lewis & Bockius, LLP

20080171320 - Methods for identifying hierarchies of constitutively expressed proteins of cell types that determine and can evoke mental states that do not contain smaller constituents: The invention provides methods for identifying brain cells that determine and can evoke subjective states that do not contain smaller constituents, by establishing a correspondence between intrinsic function of a cell type with its hierarchy of constitutively-expressed proteins. The hierarchy level of a dysfunctional protein is of diagnostic value and... Agent: Daniel Alroy

20080171338 - Methylation profile of neuroinflammatory demyelinating diseases: The present invention relates to compositions and methods for diagnosing neuroinflammatory demyelinating diseases, including but not limited to, multiple sclerosis. In particular, the present invention provides methods of identifying methylation patterns in genes associated with neuroinflammatory demyelinating diseases.... Agent: Andrus, Sceales, Starke & Sawall, LLP

20080171322 - Molecular biosensors for use in competition assays: The invention generally provides molecular biosensors. The molecular biosensors are useful in competition assays to detect the presence of a target molecule.... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080171316 - Molecular characterization with carbon nanotube control: There is provided a first reservoir containing a liquid solution including a molecule to be characterized and a second reservoir for containing a liquid solution including a molecule that has been characterized. A solid state support structure is provided including an aperture having a molecular entrance providing a fluidic connection... Agent: Theresa A Lober T.a. Lober Patent Services

20080171337 - Nucleic acid isolation method by heating on magnetic support: A method for isolating a nucleic acid from a cell-containing sample by using a magnet with a removable cover attached thereto and a plurality of containers arranged on a table, the plurality of containers having (1) a first container for mixing a cell-containing sample and magnetic beads to which cells... Agent: Cantor Colburn, LLP

20080171319 - Osteoporosis associated markers and methods of use thereof: Disclosed are methods of identifying subjects with osteoporosis or osteopenia, subjects at risk for developing osteoporosis, osteopenia, and bone fractures, methods of evaluating the effectiveness of osteoporosis treatments in subjects with osteoporosis or osteopenia, and methods of selecting therapies for treating osteoporosis or osteopenia, using biomarkers.... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo Attn: Patent Intake Customer No. 35437

20080171336 - Polymorphisms in the urocortin 3 gene and their associations with marbling and subcutaneous fat depth in beef cattle: Aspects of the present invention also provide methods based on novel UCN3 nucleotide polymorphisms selected from the group consisting of AAFC03043460.1:g.8272-8281AATAATAAAT(SEQ ID NO: 9)>GGAGC, g.8208C>T, g.8265C>T, g.8287T>C, g.8412A>G, g.8426T>A, c.8786C>T, g.9074T>C, c.12609C>T, c.12621T>C, c.12667T>G and c.12669C>A, which may provide novel markers for marbling and/or subcutaneous fat. Additional aspects provide for... Agent: Frommer Lawrence & Haug

20080171321 - Qtl controlling sclerotinia stem rot resistance in soybean: Markers associated with Sclerotinia stem rot resistance are provided. Methods of identifying resistant, and susceptible plants, using the markers are provided. Methods for identifying and isolating QTL are a feature of the invention, as are QTL associated with Sclerotinia stem rot resistance.... Agent: Law Offices Of Jonathan Alan Quine

20080171328 - Screening assays for hedgehog agonists and antagonists: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by embryonic patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods... Agent: Ropes & Gray LLP

20080171317 - Site-specific labeling of proteins for nmr studies: Methods of producing and/or analyzing spectroscopically labeled proteins, e.g., proteins site-specifically labeled with NMR active isotopes, spin-labels, chelators for paramagnetic metals, and the like, are provided. The labeled proteins are produced in translation systems including orthogonal aminoacyl tRNA synthetase/tRNA pairs. Methods for assigning NMR resonances, e.g., methods using isotopically labeled... Agent: Quine Intellectual Property Law Group, P.C.

20080171340 - Detection of analytes using reorganization energy: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.... Agent: Morgan, Lewis & Bockius, LLP

20080171341 - Detection of conformationally altered proteins and prions: The invention provides methods and kits for detecting conformationally altered proteins and prions in a sample. In one embodiment, the conformationally altered proteins and prions are associated with amyloidogenic diseases.... Agent: Foley And Lardner LLP Suite 500

20080171342 - Fluidic devices and controlling methods thereof: A fluidic device for performing assays can include control components such as vacuum pumps, gas pumps, “broken open valves,” and “self-close valves” for controlling the flow of fluids in the fluidic device. The vacuum pump can be used to pull a fluid in a specific direction in a channel, and... Agent: Jianq Chyun Intellectual Property Office

20080171339 - Novel members of the capsaicin/vanilloid receptor family of proteins and uses thereof: The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR-2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors... Agent: Banner & Witcoff, Ltd.

20080171343 - Screening assays for binding antagonists of the amd-associated variant of factor h (h384): The invention relates to identifying agents which have the ability to preferentially inhibit binding to targets such as heparin of the H384 allotypic variant of human complement Factor H, the allotypic variant associated with age-related macular degeneration (AMD), and the non-disease associated form of the same factor (Y384). The targets... Agent: Morrison & Foerster LLP

20080171345 - Biomarkers of tuberculosis that distinguish disease categories: use as serodiagnostic antigens: Mycobacterial proteins from culture filtrate or cytosol are disclosed as being useful B cell antigens for early diagnosis of mycobacterial disease, particularly in humans. These proteins include four that had not previously been recognized as B cell antigens (LppZ protein encoded by Mtb gene Rv3006; SodC protein encoded by Mtb... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080171346 - Immunosensors: scfv-linker design for surface immobilization: An apparatus and methods for binding an analyte of interest in a sample are provided. The apparatus comprises a substrate with an exposed surface with an compound, that is electrostatically charged or capable of forming hydrogen bonds, provided bound to the solid substrate. A recombinant single chain antibody (scFv) molecule... Agent: Ian C. Mcleod Ian C. Mcleod, P.C.

20080171344 - Methods, kits and materials for diagnosing disease states by measuring isoforms or proforms of myeloperoxidase: There exists a need in the art for diagnosing specific disease states through measuring a concentration myeloperoxidase (MPO) isoform and/or proform or a combination thereof in a test sample. The claimed method provides a high specificity assay that has improved diagnostic specificity and improved sensitivity in that it reduces detection... Agent: Sterne Kessler Goldstein & Fox, P.l.l.c.

20080171347 - Determining and reducing immunoresistance to botulinum toxin therapy using botulinum toxin a peptides: The present invention provides BoNT/A peptide compositions, tolerogizing compositions, BoNT/A immune response inducing compositions and antibody compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of preventing or reducing immunoresistance to botulinum toxin therapy in an individual, methods of vaccinating an individual against... Agent: Allergan, Inc.

20080171348 - Gfp-snap25 fluorescence release assay for botulinum toxin protease activity: The present invention provides a nucleic acid molecule which contains a nucleotide sequence encoding a SNAP-25 substrate which includes (i) a green fluorescent protein; (ii) a first partner of an affinity couple; and (iii) a portion of SNAP-25 that includes a BoNT/A, BoNT/C1 or BoNT/E recognition sequence containing a cleavage... Agent: Allergen, Inc. (t2-7h)

20080171349 - Alzheimer's disease secretase, app substrates therefor and uses therefor: The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates,... Agent: Marshall, Gerstein & Borun LLP

20080171352 - Methods and compositions for highly sensitive detection of molecules: Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide... Agent: Wilson Sonsini Goodrich & Rosati

20080171354 - Natriuretic peptide ratio for diagnosing cardiac dysfunctions: The present invention is a method for diagnosing a cardiac dysfunction in a subject comprising the steps of measuring, preferably in vitro, the level of a BNP-type peptide in a sample from the subject, measuring, preferably in vitro, the level of an ANP-type peptide in a sample from the subject,... Agent: Roche Diagnostics Operations Inc.

20080171350 - Neural cell differentiation method from es cells: A method for inducing differentiation of embryonic stem cells into neuronal precursors is provided as well as an assay for neuronal precursor or progenitor cells and a method for identifying agents that inhibit or reduce an increase in neurite degeneration.... Agent: Novartis Corporate Intellectual Property

20080171353 - Novel guanosine triphosphate-binding protein-coupled receptor place6002312, its gene, and production and uses thereof: The clone PLACE6002312 having a structure characteristic of G protein-coupled receptor was isolated from a human placental full-length cDNA library prepared by the oligo-capping method. Database search revealed that PLACE6002312 had the highest homology to HISTAMINE H2 RECEPTOR. Analysis for the expression of PLACE6002312 gene in human tissues revealed that... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080171351 - Probes for anionic cell surface detection: Embodiments of the present invention are generally directed to compositions comprising a class of molecular probes for detecting the presence of anionic cell surfaces. Embodiments include compositions that are enriched for these compositions and preparations, particularly preparations suitable for use as laboratory/clinical reagents and diagnostic indicators, either alone or as... Agent: Schwabe, Williamson & Wyatt, P.C. Pacwest Center, Suite 1900

20080171355 - Device for testing the effectiveness of disinfectants on protozoan parasites: This invention relates to a device for testing the efficacy of any disinfectant treatment, such as water disinfectants or equipment disinfectants. The device includes a culture of live unsporulated free-living protozoan parasites. If the disinfectant treatment successfully kills all or a substantial number of parasites, then the treatment is effective.... Agent: Smart & Biggar P.o. Box 2999, Station D

20080171357 - Method for producing tripeptides and/or peptides longer than tripeptides: A method is disclosed that allows the production of peptides having three or more amino acid residues easily, inexpensively and at high yield without going through a complex synthesis method. A novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium is... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080171356 - Process for producing soybean protein: A soybean protein that without any soybean odor and nasty aftertastes, such as acerbity and astringency, is refreshing and ensures excellent flavor, and that when used in a protein beverage, etc., excels in powder dispersion and dissolution at the time of dissolving operation and is free of roughness thereof, realizing... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080171361 - Cap-independent translational enhancer for protein synthesis in wheat germ extract and transgenic cereals: Novel cap-independent translational enhancers (CITEs) from monocot-infecting members of the virus family Tombusviridae (e.g. Maize necrotic streak virus) are provided. The CITEs can be used to produce uncapped mRNA that is efficiently translated into protein, for example, in wheat germ extract or in transgenic cereals or grasses.... Agent: Fellers Snider Blankenship Bailey & Tippens

20080171358 - Expression system: The present invention relates generally to methods and compositions for expression of polypeptides or delivery of interfering RNA's in various cell types.... Agent: Fish & Richardson, PC

20080171360 - Penicillium capsulatum arabinofuranosidases: The present invention relates to isolated polypeptides having alpha-L-arabinofuranosidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.... Agent: Novozymes North America, Inc.

20080171359 - Recombinant yeasts for synthesizing epoxide hydrolases: The invention provides isolated Y. lipolytica cells and substantially pure cultures of Y. lipolytica cells containing exogenous nucleic acids encoding EH polypeptides, e.g., enantioselective EH polypeptides. Also featured by the invention are methods for the production of the EH polypeptides and methods for hydrolysing epoxides and for producing optically active... Agent: Fish & Richardson P.C.

20080171363 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department

20080171362 - Polynucleotides encoding proteins with clot-specific streptokinase activity: The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen... Agent: Sughrue Mion, PLLC

20080171364 - Methods and compositions for amplification and capture of nucleic acid sequences: A method for amplification and capture of nucleic acid sequences can include the steps of annealing a forward primer to a DNA or RNA template in a first reaction vessel that includes fewer than four different dNTPs; extending the forward primer with the dNTPs to form an extended primer that... Agent: James P. Broder Roeder & Broder LLP

20080171366 - Method and apparatus for disrupting cells and amplifying nucleic acids using gold nanorods: Provided is a method of disrupting cells comprising adding gold nanorods to a solution containing cells and irradiating the gold nanorods with a laser to disrupt the cells. A method and an apparatus for continuously disrupting cells and amplifying nucleic acids in a single microchamber are also provided, wherein the... Agent: Cantor Colburn, LLP

20080171365 - Method of mutagenesis: The present invention relates to a method of mutagenesis for introducing mutations into a molecule and, in particular, to methods that may be applied to populations of molecules for the generation or screening of libraries involving the mutation of multiple molecules.... Agent: Klarquist Sparkman, LLP

20080171367 - Heparan sulfate glycosaminoglycan lyase and uses thereof: The invention provides recombinant B. thetaiotaomicron GAG lyase polypeptides. The invention also provides nucleic acid molecules encoding such polypeptides, recombinant expression vectors containing B. thetaiotaomicron GAG lyase nucleic acid molecules, and host cells into which the expression vectors have been introduced. Characterization, diagnostic and therapeutic methods utilizing compositions of the... Agent: Lowrie, Lando & Anastasi, LLP

20080171368 - Microorganism of enterobacteriacae genus haboring genes associated with l-carnitine biosynthesis and method of producing l-carnitine using the microorganism: Provided is a microorganism that belongs to Enterobacteriacae and a method of producing L-carnitine using the same. The microorganism includes polynucleotide encoding activity of S-adenosylmethionine-6-N-iysine KDa methyltransferase from Neurospora crassa, polynucleotide encoding activity of 6-N-trimethyllysine hydroxylase, polynucleotide encoding activity of 3-hydroxy-6-N-trimethyllysine aldolase, and polynucleotide encoding activity of γ-trimethylaminoaldehyde dehydrogenase and... Agent: Cantor Colburn, LLP

20080171369 - Method for employing ear corn in the manufacture of ethanol: Ear corn is picked from corn fields by ear corn harvesters and transported to a central shelling station associated with an ethanol manufacturing facility. Shelled corn from the central shelling station is processed into ethanol at the ethanol manufacturing facility, and corn cobs from the central shelling station are burned... Agent: Marshall, Gerstein & Borun LLP

20080171370 - Detoxifying pre-treated lignocellulose-containing materials: The invention relates to a process of detoxifying pretreated lignocellulose-containing maternal by subjecting pre-treated material to a detoxifying compound capable of binding 1) pre-treated lignocellulose degradation products and/or 2) acetic acid. The detoxifying compound may also be an amidase and/or and anhydrase. The invention also relates to a process of... Agent: Novozymes North America, Inc.

20080171371 - Dna fragment having promoter function: e

20080171372 - Process for dynamic concentration and separation of bacteria: A method and apparatus for concentration and separation of bacteria in confined geometries such as in thin fluid films and in channels. The bacteria live in an environment of a specified level of pH, so that an increase or decrease of pH levels stimulates the bacteria to avoid areas of... Agent: Joan Pennington

20080171373 - Processes for producing coenzyme q10: The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus-produced reduced coenzyme Q10. The present invention also... Agent: Brinks Hofer Gilson & Lione

20080171374 - Method to improve the stability and broaden the ph range of family g/11 xylanases: The present invention relates to protein engineering, and concerns especially family G/11 xylanases, and genes encoding said enzymes. In specific, the invention concerns Trichoderma reesei XYNII gene, which codes for endo-1,4-β-xylanase (EC 3.2.1.8). The invention describes how site-directed mutagenesis can be used to improve the properties of an enzyme to... Agent: Genencor Division Danisco Us, Inc.

20080171375 - Heparan sulfate glycosaminoglycan lyase and uses thereof: The invention provides recombinant B. thetaiotaomicron HSGAG lyase polypeptides. The invention also provides nucleic acid molecules encoding such polypeptides, recombinant expression vectors containing B. thetaiotaomicron HSGAG lyase nucleic acid molecules, and host cells into which the expression vectors have been introduced. Characterization, diagnostic and therapeutic methods utilizing compositions of the... Agent: Lowrie, Lando & Anastasi, LLP

20080171376 - Modified bacteriocins and methods for their use: Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed as are methods for producing them in GRAS organisms. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners,... Agent: Townsend And Townsend And Crew, LLP

20080171377 - Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid: The present invention relates to crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, pharmaceutical compositions and dosage forms comprising the crystalline forms, methods of making the crystalline forms and methods for their use for the treatment, prevention or management of diseases ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay.... Agent: Jones Day

20080171378 - Genetically modified host cells and use of same for producing isoprenoid compounds: The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for... Agent: Bozicevic, Field & Francis LLP

20080171379 - Compositions and methods for removing hard water deposits with growth medium: Compositions and methods for removing hard water deposits through the use of a microorganism growth medium are disclosed. Any known or novel growth medium may be used for the purpose of removing hard water deposits. The growth medium may be applied to the hard water deposits, left long enough for... Agent: Kirton And Mcconkie

20080171380 - Microfluidic assembly with reagent: A microfluidic assembly, comprises a first region having a first affinity to a first fluid sample and a second region having a second affinity to the first fluid sample. The first affinity is greater than the second affinity. A first reagent is positioned within at least the first region, the... Agent: Burr & Brown

20080171382 - Method and device for detecting the presence of a single target nucleic acid in a sample: A microfluidic device comprising a first sample chamber and a first sample portion positioned in the first sample chamber. If the first sample portion contains a single molecule of a target nucleic acid, the first sample portion would attain a detectable concentration of the target nucleic acid after a single... Agent: Burr & Brown

20080171381 - Method and device for the multiplex cells and tissues analysis: We combined different particles in same reaction vessel for realizing multiple assays for cells or tissues analysis. These particles are identified by their mark as different color or fluorescence. Then differently identified cells/tissues are analyzed according to their response to the outside signals evenly. We can apply any signals as... Agent: Hiroyuki Yonekawa

20080171383 - Optical interface for disposable bioreactors:

20080171385 - Culture of stem cells: While culture medium and systems have been described that permit the culture and proliferation of human embryonic stem cells in feeder free and animal product free conditions, these conditions will not readily support cloning of an embryonic stem cell culture meaning, at least here, the initiation of a sub-culture using... Agent: Quarles & Brady LLP

20080171384 - Method of obtaining a population of human haemopoietic stem cells: The present invention relates to a method for the isolation of large numbers of hematopoietic stem cells. In particular the invention relates to a method for the isolation of viable haemopoietic stem cells from the placenta. The uses of these isolated cells in various applications are also described.... Agent: Edwards Angell Palmer & Dodge LLP

20080171386 - Method and apparatus for sustaining viability of biological cells on a substrate: A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular... Agent: Ornl-utb-luedeka, Neely & Graham

20080171388 - Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis: The present invention relates to nucleic acid inhibitors, compositions and method for enhancing synthesis of nucleic acid molecules. In a preferred aspect, the invention relates to inhibition or control of nucleic acid synthesis, sequencing or amplification. Specifically, the present invention discloses nucleic acids having affinity for polypeptides with polymerase activity... Agent: Invitrogen Corporation C/o Intellevate

20080171387 - Method for modulating cell proliferation: Methods for modulating transcriptional activation and cellular proliferation based on targeting the direct interaction of BRCA1 with the mammalian SWI/SNF complex through association with its BRG1 subunit are provided. Also provided are compositions for modulating cellular proliferation by modulating chromatin remodeling activity in mammalian cells which targets a BRG1 subunit... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20080171389 - Nitrile hydratases from metagenome libraries: The present invention is concerned with the preparation of novel nitrile hydratases. These latter are preferably obtained from nonculturable organisms by means of a PCR-based screening, in metagenome DNA libraries, using special degenerate primers.... Agent: Pillsbury Winthrop Shaw Pittman LLP

20080171390 - Adenovirus vectors containing cell status-specific response elements and methods of use thereof: The present invention provides adenoviral vectors comprising cell status-specific transcriptional regulatory elements which confer cell status-specific transcriptional regulation on an adenoviral gene. A “cell status” is generally a reversible physiological and/or environmental state. The invention further provides compositions and host cells comprising the vectors, as well as methods of using... Agent: Ropes & Gray LLP

20080171391 - Methods and means for altering fiber characteristics in fiber-producing plants: Methods and means are provided for modulating fiber length in fiber producing plants such as cotton by altering the fiber elongation phase. The fiber elongation phase may be increased or decreased by interfering with callose deposition in plasmodesmata at the base of the fiber cells.... Agent: Buchanan, Ingersoll & Rooney PC

20080166694 - Plant tissue packaging process: A method is provided for packaging harvested plant tissues, such as agricultural products. Embodiments of the present invention mitigate damage to harvested plant tissues due to excessive ripening and spoilage, by contacting the plant tissues with ozone during transportation and storage. For example, in some embodiments harvested plant tissues are... Agent: Carr & Ferrell LLP

20080166695 - Solution for the storage and perfusion of organs awaiting transplantation: A storage solution to maintain and perfuse organs awaiting transplantation comprising (a) an isotonic balanced solution comprising a physiologically acceptable amount of potassium, mono acidic phosphate, biacidic phosphate, chloride, sodium and bicarbonate ions; (b) 50-250 mM glucose; (c) 0.2-20 mM of an alkanoyl L-carnitine or a physiologically acceptable salt thereof;... Agent: Nixon & Vanderhye, PC

20080166697 - Determination of testosterone by mass spectrometry: Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present... Agent: Foley & Lardner LLP

20080166696 - Method for analyzing proteins: o

20080166698 - Antibodies for cancer therapy and diagnosis: The present application describes a method for making antibodies which can be used for cancer diagnosis or therapy. The application also discloses a method for identifying an antigen which is differentially expressed on the surface of two or more distinct cell populations. The application additionally describes human antibodies directed against... Agent: Heller Ehrman LLP

20080166701 - Immunoassay method and immunoassay kit to be used therein: In an immunoassay method using an antibody sensitization particle, the occurrence of false positives is prevented. The immunoassay method of the present invention is an immunoassay method for detecting or quantifying an analyte in a specimen by mixing an antibody sensitization particle obtained by sensitizing a particle with an antibody... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20080166700 - Method for detecting viable cells in a sample by using a virus: A method for detecting viable cells such as bacterial cells, within a sample, said method comprising (i) incubating said sample with a virus which is able to infect said cells under conditions which allow said virus to infect and replicate within any such cells which are viable; (ii) detecting any... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080166699 - Method to identify disease resistant quantitative trait loci in soybean and compositions thereof: The present invention is in the field of plant breeding and genetics, particularly as it pertains to the genus, Glycine. More specifically, the invention relates to a method for screening soybean plants containing one or more quantitative trait loci for disease resistance, species of Glycine having such loci and methods... Agent: Monsanto Company

20080166702 - Viral diagnostic method and well for use in same: The present invention relates to a single flat-based well suitable for use in a viral diagnostic method. More particularly, the well has a planar or flat base, as opposed to a curved base. The invention also relates to a viral diagnostic method that employs such single wells. In an embodiment... Agent: Brooks Kushman P.C.

20080166717 - Angiopoietin-like 2 as a biomarker of vascular endothelial cell abnormal function and senescence: A method for assessing a physiological state of a mammal. The method includes: obtaining from the mammal a biological sample; measuring the expression of angiopoietin-like 2 in the biological sample; and assessing the physiological state of the mammal by comparing the measured expression of the angiopoietin-like 2 to a predetermined... Agent: Louis Tessier

20080166711 - Assays for tert promoter modulatory agents: Methods and compositions for assaying an agent for TERT promoter modulatory activity are provided. In the subject methods, an agent is contacted with a cell comprising a mutant telomerase structural RNA component (TR) that results in a detectable phenotype in the presence of telomerase reverse transcriptase (TERT). Also provided are... Agent: Bozicevic, Field & Francis LLP

20080166713 - Atm related kinase, atx, nucleic acids encoding same and methods of use: The invention provides an isolated nucleic acid molecule having substantially the same nucleotide sequence as SEQ ID NO:1. Also provided is an isolated oligonucleotide having at least 15 contiguous nucleotides of a nucleotide sequence referenced as SEQ ID NO:11. An isolated polypeptide having substantially the same amino acid sequence as... Agent: Mcdermott, Will & Emery

20080166723 - Cdk5 genetic markers associated with galantamine response: Haplotypes in the CDK5 gene associated with cognitive response to galantamine treatment are disclosed. Compositions and methods for detecting and using these CDK5 haplotypes in a variety of clinical applications are disclosed. Such applications include articles of manufacture comprising galantamine or derivatives thereof that are approved for treating patients having... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080166725 - Corn event das-59122-7 and methods for detection thereof: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DAS-59122-7 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and... Agent: Pioneer Hi-bred International, Inc.

20080166726 - Corn event das-59122-7 and methods for detection thereof: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DAS-59122-7 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and... Agent: Pioneer Hi-bred International, Inc.

20080166710 - Detection of nucleic acid associated with disease: The present invention provides methods for obtaining information regarding nucleic acid from an individual and nucleic acid associated with a disease of the individual, in particular when the disease is associated with a pathogenic microorganism present within the individual. The present invention also provide probe-immobilized substrates, such as probe-immobilized chips,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080166712 - Gene detection method: A gene detection method comprises an immobilization step of forming a single-stranded capture probe having a base sequence that is complementary to the target gene to be detected, and immobilizing the capture probe to a solid phase; a gene sample formation step of forming a gene sample by denaturing the... Agent: Wenderoth, Lind & Ponack L.L.P.

20080166727 - Heat and ph measurement for sequencing of dna: The present method involves sequencing by synthesis in which a template strand having an attached primer is immobilized in a small volume reaction mixture. In one embodiment, the reaction mixture is in contact with a sensitive heat sensor, which detects the heat of reaction from incorporation of a complementary base... Agent: The Board Of Trustees Of The Leland Stanford Junior University

20080166708 - Markers and methods for prenatal of chromosal alberrations: The invention concerns prenatal screening of chromosomal aberrations, more particularly, through identification of novel markers of chromosomal aberrations, in particular, trisomy 21, whereof the assay based on a body fluid of the pregnant woman enables, alone or in combination with other assays, the probability that the fetus suffers from a... Agent: Alston & Bird LLP

20080166709 - Marks as modifiers of the p53 pathway and methods of use: Human MARK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MARK are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20080166720 - Method and apparatus for rapid nucleic acid analysis: A system for detecting the presence of a target nucleic acid sequence in a sample includes a microfluidic device having a droplet generation region for forming a plurality of droplets, the droplet generation region being operatively coupled to a sample inlet coupled to a sample source, a molecular beacon inlet... Agent: VistaIPLaw Group LLP

20080166707 - Method for detecting ncrna: Described is a novel method for the detection of ncRNA molecules. The disclosed method is especially useful for the detection miRNA and siRNA. The method can be used to generate a profile of the ncRNA molecules present in a sample. In addition, using the methods of the present disclosure a... Agent: Bradley Arant Rose & White, LLP Intellectual Property Department-nwj

20080166733 - Method for determining the prognosis of cancer patients by measuring levels of bag expression: In accordance with the present invention, there are provided methods for determining a prognosis of disease free or overall survival in a patient suffering from cancer. Also provided are methods for predicting the risk of tumor recurrence or spread in an individual having a cancer tumor. Methods for screening a... Agent: Mcdermott, Will & Emery

20080166704 - Method for quantitative evaluation of a rearrangement or a targeted genetic recombination of an individual and uses thereof: A method for quantitative evaluation of a rearrangement or targeted genetic recombination of an individual and the immunity repertoire of an individual and the uses thereof, particularly in the case of follow-up to a treatment or in the diagnosis and/or prognosis of certain pathologies. Said method comprises at least: (a)... Agent: Morgan Lewis & Bockius LLP

20080166729 - Method of predicting risk of lung cancer recurrence, and a composition, kit and microarray for the same: Provided is a method of predicting risk of lung cancer recurrence in a lung cancer patient or after a patient has lung cancer treatment, the method including: obtaining a biological sample from a lung cancer patient; measuring an expression level of at least one marker gene from the biological sample,... Agent: Cantor Colburn, LLP

20080166721 - Methods and compositions for determining predisposition to inflammation-mediated cardiovascular disease: The present invention provides methods and compositions for detecting a predisposition to an inflammation-mediated cardiovascular disease in a human subject by detecting a level of leukotriene C4 synthase (LTC4S) gene product in a sample from a human subject indicative of a predisposition to an inflammation-mediated cardiovascular disease or detecting the... Agent: Bozicevic, Field & Francis LLP

20080166719 - Methods for diagnosing irritable bowel syndrome: The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with irritable bowel syndrome (IBS). In particular, the present invention is useful for classifying a sample from an individual as an IBS sample using a statistical algorithm and/or empirical data. The... Agent: Townsend And Townsend And Crew, LLP

20080166706 - Novel gold nanoparticle aggregates and their applications: The invention is drawn to novel gold nanoparticles that are used in a dual optical method for sensitive and selective detection of antigens. The gold nanoparticle aggregates are synthesized from gold hydrochloride and sulfur salts in an aqueous solution. The aggregates can be selectively sized using a spectral notch filter... Agent: Bell & Associates

20080166732 - Novel human poly(a)polymerase gamma (pap gamma): The present invention relates to a novel human poly(A) polymerase enzyme (PAP), its nucleic and amino acid sequence and use thereof as well as an antibody against the novel enzyme and use thereof. The novel enzyme named PAPγ and is not related to the previously known PAPs.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080166705 - Optoelectronic detection system: The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080166731 - Plant caffeic acid-3-o-methytransferase homologs: This invention relates to an isolated nucleic acid fragment encoding a protein involved in phenylpropanoid metabolism. The invention also relates to the construction of a chimeric gene encoding all or a portion of the protein involved in phenylpropanoid metabolism, in sense or antisense orientation, wherein expression of the chimeric gene... Agent: Potter Anderson & Corroon LLP Attn: Kathleen W. Geiger, Esq.

20080166703 - Rapid and low cost method for isolating nucleic acid: The invention relates to a rapid method for isolating nucleic acid from a nucleic acid source, wherein the nucleic acid source is lysed in the absence of a chaotropic salt and in the absence of an alcohol. The lysate is subsequently filtered through a porous matrix consisting of a material... Agent: Mcdermott Will & Emery LLP

20080166718 - Repertoire determination of a lymphocyte b population: The present invention provides a process for determining the quantitative and qualitative profile of the repertoire of a given type of an immunoglobulin (Ig) heavy chain expressed by a B lymphocyte population present in a tissue sample, and kits and uses thereof. It also provides a set of VH forward... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080166722 - Sequences diagnostic for shrimp pathogens: Primers have been isolated that are diagnostic for the detection of Vibrio harveyi. The primers are based on a portion of the Vibrio harveyi LuxR gene and may be used in primer directed amplification or nucleic acid hybridization assay methods.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080166728 - System and method of measuring methylation of nucleic acids: The present embodiments relate to a system and method of measuring the methylation level of DNA. Some embodiments relate to a system and method of measuring methylation level of DNA with a gene array.... Agent: Knobbe Martens Olson & Bear LLP

20080166714 - Systems for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: Searete LLC Suite 110

20080166715 - Systems for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: Searete LLC Clarence T. Tegreene

20080166716 - Systems for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: Searete LLC Clarence T. Tegreene

20080166730 - Therapeutic and diagnostic proteins comprising a socs box: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated signal transduction. The molecules of the present invention are useful, therefore, in modulating cellular responsiveness to cytokines as well as... Agent: Scully, Scott, Murphy & Presser

20080166724 - Vegf-modulated genes and methods employing them: e

20080166734 - Genes and methods of using the same for diagnosis and for targeting the therapy of cardiovascular disease: The invention is a method of classifying, diagnosing, prognosticating, and predicting cardiovascular disease conditions or other biological states using genes identified using microarray technology.... Agent: Agilent Technologies Inc.

20080166735 - Metabolic method to identify compounds: The invention is concerned with the identification of compounds as flavours or fragrances, their precursors, or as modulators of the perception of fragrances or flavours. The method comprises a reaction of a compound with a metabolic enzyme expressed in the nose, mouth or respiratory tract, followed by a method of... Agent: Curatolo Sidoti Co., Lpa

20080166737 - Method for diagnosing tumors: The present invention describes a method for diagnosing tumours of the reproductive organs which is characterised by determination of the afamin content in a sample of a body fluid or in a tissue sample, wherein a tumour is diagnosed if the afamin content in the sample is decreased compared to... Agent: Fulbright & Jaworski L.L.P.

20080166738 - Methods and assays for detecting gp73-specific autoantibodies: The present invention provides a method for detecting autoantibodies in a subject which reacts with a GP73 antigen. Increased levels of GP73-specific autoantibodies in a sample from the subject which bind to GP73 antigen are indicative of liver disease in the subject.... Agent: Gordon & Rees LLP

20080166736 - Pdz domain interactions and lipid rafts: Methods for modulating immune cell signaling are provided. In general such methods involve modulating an interaction between a PDZ protein and a PDZ ligand protein whose interaction affects the composition and/or distribution of lipid rafts in an immune cell. Modulators that enhance or inhibit such interactions are also disclosed, as... Agent: Townsend And Townsend And Crew, LLP

20080166739 - Gfp-snap25 fluorescence release assay for botulinum toxin protease activity: The present invention provides a nucleic acid molecule which contains a nucleotide sequence encoding a SNAP-25 substrate which includes (i) a green fluorescent protein; (ii) a first partner of an affinity couple; and (iii) a portion of SNAP-25 that includes a BoNT/A, BoNT/C1 or BoNT/E recognition sequence containing a cleavage... Agent: Allergan, Inc.

20080166740 - Multiple immunochemistry assays on an element: A method of analyzing a sample for one or more analytes of interest includes: providing an element having a base layer; a layer containing streptavidin; a spreading layer, wherein the streptavidin may or may not be in the spreading layer; providing immunocomponents and labeled immunoreactants which may be in the... Agent: Philip S. Johnson Johnson & Johnson

20080166741 - Method for diagnosing membranous glomerulonephritis disease and a kit thereof: Some specific autoantigens of MGN are discovered by using the integrated platform. Moreover, according to the specificity between antibodies and antigens, a method for diagnosing MGN are constructed. This diagnostic method is cooperated with ELISA, RIA, immunofluorescence, or other immunochromatography techniques. Finally, a diagnostic kit is provided to implement the... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20080166742 - Method of detecting or monitoring a malignant plasma cell disease: A method of detecting or monitoring a malignant plasma cell disease comprising detecting in a sample the ratio between the relative amounts of immunoglobulins having: (i) a heavy chain class bound to λ light chains; and (ii) immunoglobulins having the same heavy chain class but bound to κ light chains.... Agent: Barnes & Thornburg LLP

20080166744 - Method and device for monitoring inhibition of platelet function: The invention provides a method of monitoring the response of platelets to a COX1 inhibitor such as aspirin. The method involves collecting platelet-containing mammalian blood treated with a COX1 inhibitor; mixing the blood with a COX1-dependent platelet agonist, such as arachidonic acid, monitoring extracellular ATP in the agonist-activated blood to... Agent: Lemaire Patent Law Firm, P.l.l.c.

20080166743 - Trp8, a transient receptor potential channel expressed in taste receptor cells: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion... Agent: Nixon Peabody LLP - Patent Group

20080166745 - Device and method for measuring ldl-associated cholesterol: An assay device and method for determining the concentration of low density lipoprotein (LDL)-associated cholesterol (LDL-C) in a body-fluid sample, such as a blood sample is described.... Agent: Wilson Sonsini Goodrich & Rosati

20080166746 - Method of lipid assay and reagent for use therein: A method of lipid assay characterized by assaying the lipids contained in a blood component in the presence of an organic silicon compound. The method can cause specific conditions for direct methods while satisfying requirements such as no influence on precision of assay, no burden on assay apparatus, and easy... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080166747 - Biosensor: Biosensors are made by attaching covalently or non-covalently at least one reporter group to one or more specific positions of a bacterial periplasmic binding protein (bPBP). Upon binding of ligand to the biosensor, there is a change in the signal transduced by the reporter group.... Agent: Nixon & Vanderhye, PC

20080166749 - Fluorescent protein sensors of post-translational modifications: The present invention includes a fluorescent compound that can detect an activity, such as an enzymatic activity, and exhibits quenching. The fluorescent compound can include a fluorescent protein, such as an Aequorea-related green fluorescent protein. The fluorescent compound can include a substrate site for an enzymatic activity such as a... Agent: Invitrogen Corporation C/o Intellevate

20080166748 - Method of identifying protein cams (constitutively active mutants): The present invention relates to a method of identifying protein Constitutively Active Mutants (CAMs) and the use thereof.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080166751 - Method of analyzing dynamics in the differentiation of vascular endothelial progenitor cells: The present invention provides a method of forming an EPC colony with good reproducibility, and a method of analyzing the dynamics of EPC differentiation in the body of patient. More specifically, the present invention provides a method of analyzing the dynamics of differentiation of endothelial progenitor cells, which includes culturing... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080166750 - Methods of optimizing drug therapeutic efficacy for treatment of immune-mediated gastrointestinal disorders: The present invention provides a method of optimizing therapeutic efficacy and reducing toxicity associated with 6-mercaptopurine drug treatment of an immune-mediated gastrointestinal disorder such as inflammatory bowel disease. The method of the invention includes the step of determining the level of one or more 6-mercaptopurine metabolites in the patient having... Agent: Townsend And Townsend And Crew, LLP

20080166752 - Microbial sampling device: Aspects of the present invention provide novel apparatus and methods for sampling microbial organisms present on surfaces. Preferred apparatus comprises: a reservoir suitable for providing microbial collection fluid; a sterilizable sample collection chamber; a sterilizable, integrated collection fluid delivery and collection fluid recovery member, suitable to deliver collection fluid to... Agent: Davis Wright Tremaine, LLP/seattle

20080166753 - Microbial growth assay: Susceptibility of sessile microorganisms to antimicrobial agents is tested with a method comprising growing the microorganisms on a support to form a biofilm, contacting the biofilm with a metabolic substrate having a chromogenic and/or fluorogenic moiety to continue a base-line metabolic activity of the biofilm, contacting the biofilm with one... Agent: Fish & Richardson P.C.

20080166754 - Plant caffeic acid-3-o-methyltransferase homologs: This invention relates to an isolated nucleic acid fragment encoding a protein involved in phenylpropanoid metabolism. The invention also relates to the construction of a chimeric gene encoding all or a portion of the protein involved in phenylpropanoid metabolism, in sense or antisense orientation, wherein expression of the chimeric gene... Agent: Potter Anderson & Corroon LLP Attn: Kathleen W. Geiger, Esq.

20080166758 - Adeno-associated viruses and uses thereof: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention... Agent: Schwegman, Lundberg & Woessner, P.A.

20080166759 - Altered polypeptides with increased half-life: Polypeptides that are cleared from the kidney and do not contain in their original form a Fc region of an IgG are altered so as to comprise a salvage receptor binding epitope of an Fc region of an IgG and thereby have increased circulatory half-life.... Agent: Morrison & Foerster LLP

20080166760 - Compositions and methods for enzymatic detachment of bacterial and fungal biofilms: Isolated nucleic acid sequences and amino acid sequences for soluble, β-N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm are provided. An isolated mutant bacteria which forms biofilm colonies which tightly adhere to surface but which are unable to release cells into the... Agent: Merchant & Gould PC

20080166764 - Dna construct and process for the fermentative production of fusion proteins: A DNA construct that allows the inexpensive production of a target protein in E. coli, consisting of a nucleic acid sequence encoding a signal peptide which is operably linked with a gene coding for a carrier protein which is linked with a gene coding for the target protein via a... Agent: Brooks Kushman P.C.

20080166767 - Efficient production of f(ab')2 fragments in mammalian cells: The present invention provides immortalized eukaryotic cells and methods useful for the production of immunologically active bivalent antibody fragments, such as F(ab′)2 fragments. The methods and cells of the invention result in a desirable ratio of bivalent to monovalent antibody fragments.... Agent: Trask Britt

20080166765 - Fungal cell wall synthesis gene: A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, fungal genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by... Agent: Townsend And Townsend And Crew, LLP

20080166766 - Genetic incorporation of unnatural amino acids into proteins in mammalian cells: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins in mammalian host cells, for example, primate host cells and rodent host cells. The invention provides, for example but not limited to, translation systems that include host cells (e.g., primate or... Agent: Quine Intellectual Property Law Group, P.C.

20080166762 - Heterologous production of interleukin 1 receptor antagonist (il-1ra) in pichia pastoris: The invention relates to the production and expression of Interleukin 1 receptor antagonist (IL-1Ra) in expression systems, such as Pichia Pastoris (P. pastoris). For example, the present invention encompasses an engineered Pichia strain x-33/pGAPZαA/IL-1Ra constructed by cloning the IL-1Ra gene in pGAPZαA and transforming the recombinant vector into Pichia Pastoris... Agent: Foley And Lardner LLP Suite 500

20080166763 - Human toll homologues: The invention relates to the identification and isolation of novel DNAs encoding the human Toll proteins PRO285 and PRO286, and to methods and means for the recombinant production of these proteins. The invention also concerns antibodies specifically binding the PRO285 or PRO286 Toll protein.... Agent: Gates & Cooper LLP Howard Hughes Center

20080166756 - Method of producing an antibody using a cell in which the function of fucose transporter is inhibited: The present invention relates to a method of producing a recombinant protein particularly an antibody using a cell in which the function of a fucose transporter is inhibited. According to the present invention, a cell in which the expression of fucose transporter genes on both homologous chromosomes is artificially suppressed... Agent: Birch Stewart Kolasch & Birch

20080166761 - Novel peptide-forming enzyme gene: DNA and recombinant DNA that encode a peptide-forming enzyme, a method for producing a peptide-forming enzyme, and a method for producing a dipeptide are disclosed. A method for producing a dipeptide includes producing a dipeptide from a carboxy component and an amine component by using a culture of a microbe... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080166757 - Twin-arginine translocation in bacillus: Described herein are methods to enhance protein secretion in a host cell. In preferred embodiment, the host cell is a gram-positive microorganism such as a Bacillus. In another preferred embodiment, the host cell is a gram-negative microorganism. Preferably the gram-negative microorganism is an Escherichia coli or a member of the... Agent: Victoria L. Boyd Genencor Internationsl, Inc.

20080166768 - Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptide and heterodimer thereof: Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of... Agent: Amgen Inc.

20080166769 - High-copy-number, high-expression vector having methionine aminopeptidase gene: Provided is a high-copy-number, high-expression vector capable of producing a protein having satisfactory functions and activity of the same level as that of a natural form of the protein, in a large quantity and in a simple manner. Also provided is a vector including: (A) a target gene or a... Agent: Kubovcik & Kubovcik

20080166770 - Method and apparatus for amplifying and synthesisizing nucleic acid with denaturant: The invention relates generally to the field of treating a nucleic acid. More particularly, the invention provides a method for amplifying a nucleic acid and an apparatus for amplifying a nucleic acid, as well as method and apparatus for synthesizing nucleic acid to be used for the amplification.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080166771 - Method and system for detection of nucleic acids: In detecting a nucleic acid by using the nucleic acid amplification method, it is intended to shorten the time required for the measurement so as to systematically and efficiently examine a gene, etc. To achieve this object, use is made of a method of directly amplifying a nucleic acid by... Agent: Sughrue Mion, PLLC

20080166772 - Methods of increasing the concentration of a nucleic acid: We describe a method of selecting an enzyme having replicase activity, the method comprising the steps of: (a) providing a pool of nucleic acids comprising members each encoding a replicase or a variant of the replicase; (b) subdividing the pool of nucleic acids into compartments, such that each compartment comprises... Agent: Edwards Angell Palmer & Dodge LLP

20080166773 - Vectors, kits and methods for cloning dna: Vector preparations and cloning constructs suitable for use in cloning are provided. Vector preparations are double-stranded DNA molecules having two 3′ termini, each terminus having a single base pair overhang that is capable of hybridizing to a single base pair overhang on a double stranded polynucleotide sequence to be cloned.... Agent: Michael Best & Friedrich LLP

20080166755 - Intracellular delivery of osteoinductive proteins and peptides: The invention provides fusion polypeptides comprising protein transduction domains and osteoinductive polypeptides, as well as methods of using such polypeptides to induce osteogenesis and to promote proteoglycan synthesis. The invention also provides osteoinductive peptides which have demonstrated the ability to induce bone formation in vivo.... Agent: Fox Rothschild, LLP

20080166774 - Process for the production of amino acids without trehalose: The invention relates to a method for producing an amino acid comprising culturing a microorganism of the genus Corynebacterium or Brevibacterium wherein said microorganism is partially or completely deficient in at least one of the gene loci of the group which is formed by otsAB, treZ and treS, and subsequent... Agent: Lahive & Cockfield, LLP

20080166775 - P ef-tu expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP

20080166776 - Method for preparing a useful secondary metabolite by effective elimination of biological by-products: The present invention relates to a method that improves productivity of a useful secondary metabolite by eliminating biological by-products effectively during the culture of a useful secondary metabolite-producing microorganism, and more particularly, in order to efficiently eliminate biological by-products formed during the culture of Sorangium cellulosum, the present invention relates... Agent: Intellectual Property / Technology Law

20080166777 - Microorganisms and processes for enhanced production of pantothenate: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate... Agent: Lahive & Cockfield, LLP

20080166778 - Method of organic polymer degradation by dihydrolipoamide dehydrogenase: A dihydrolipoamide dehydrogenase (DLD) in a germ is recombined. The new DLD is applied in a solution to degrade an ether bond of an organic polymer. With the present invention, bioremediation is accomplished without secondary pollution of compounds which have environmental hormones.... Agent: Troxell Law Office PLLC

20080166779 - Photoautotrophic growth of microalgae for omega-3 fatty acid production: The invention provides methods of cultivating microalgae photoautotrophically outdoors to prepare concentrated microalgae products containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) docosahexaenoic acid, two long-chain polyunsaturated fatty acids found in fish oil that are very important for human and animal health. It also provides concentrated microalgae products containing EPA... Agent: Hugh Mctavish Mctavish Patent Firm

20080166780 - Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids: Disclosed is a process for growing the microflora Thraustochytrium, Schizochytrium and mixtures thereof, which includes the growing of the microflora in fermentation medium containing non-chloride containing sodium salts, in particular sodium sulfate. In a preferred embodiment of the present invention, the process produces microflora having a cell aggregate size useful... Agent: Sheridan Ross PC

20080166781 - Production of polyunsaturated fatty acids using novel cell treatment method: A method for isolating one compound or more than one compound from a biomass which contains microorganisms that have produced the compound or compounds, the method comprising the following steps: (a) preparing or obtaining wet cells having an average moisture content of between 30% and 80%; (b) subjecting the wet... Agent: Drinker Biddle & Reath (dc)

20080166782 - Abasic site endonuclease assay: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.... Agent: Townsend And Townsend And Crew, LLP

20080166783 - In vivo incorporation of unnatural amino acids: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.... Agent: Quine Intellectual Property Law Group, P.C.

20080166784 - Stable and filterable enveloped virus formulations: Envelope viruses (e.g. Newcastle disease virus (NDV)) are formulated for storage at moderately cold temperatures (e.g. −20 C). The formulation is an aqueous solution containing the enveloped virus at a concentration of from 106 PFU/mL to 1012 PFU/mL; and a non-reducing saccharide (e.g. sucrose). When the non-reducing saccharide is a... Agent: Wellstat Management Company. LLC

20080166785 - Polynucleotides allowing the expression and secretion of recombinant hbsag virus-like particles containing a foreign peptide, their production and use: The hepatitis B surface antigen (HBsAg) can assemble into sub-virion virus like particles (VLPs). Vectors comprised of polynucleotides, identified as GA1xFlag-M and GA3xFlag-M, are provided for the expression of foreign proteins in such VLPs, and for release of the VLPs from host cells containing the vectors. In one example, an... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080166786 - Pump unit, syringe unit, method for delivering particles, and method for delivering cells: The present invention relates to a pump unit or the like which feeds particles in a liquid with particles dispersed therein to a predetermined area. An object of the present invention is to obtain a sufficient solution feeding resolution while inhibiting mixture of bubbles. The pump unit includes a moving... Agent: Arent Fox LLP

20080166788 - Escherichia coli strains which over-produce l-threonine and processes for the production of l-threonine by fermentation: The present invention relates to the fields of microbiology and microbial genetics. More specifically, the invention relates to novel bacteria strains and processes employing these strains for the fermentative production of amino acids such as threonine.... Agent: Buchanan Ingersoll PC (archer Daniels Midland Company)

20080166787 - T cell apoptosis inducer: An inducer of T cell apoptosis and a health food for inducing T cell apoptosis comprising as an active ingredient of a lactic acid bacterium belonging to the genus Lactobacillus or the genus Bifidobacterium are disclosed. Particularly preferred lactic acid bacteria belonging to the genus Lactobacillus or the genus Bifidobacterium... Agent: Birch Stewart Kolasch & Birch

20080166789 - Compostable vinyl acetate polymer compositions, composites and landfill biodegradation: Compositions of vinyl acetate polymers such as polyvinyl acetate (PVAc) are rendered compostable by a monomeric adduct of an organotitanate or zirconate as a prodegradant. PVAc sheets and composites are compostable in landfills.... Agent: Wood, Herron & Evans, LLP

20080166790 - Method and system for the transformation of molecules: a process used to transform waste into energy and feedstock without releasing carbon dioxide greenhouse gas emissions: The system, based on an enclosed recirculating Carbon Flow Loop, uses plasma to neutralizes toxins within municipal waste or other feedstock. This breaks down the feedstock into its basic elements, predominantly hydrogen and carbon monoxide, known as syngas. The syngas is further processed using combustion, to transform the carbon monoxide... Agent: Eric Day

20080166791 - Universal glucometer/glucovial connector: A universal glucometer connector system comprising: a glucometer for measuring glucose concentration of blood, and having a top, bottom and side surface; a jacket for retaining the glucometer; a first opening in the jacket for receiving a glucovial that can be one of a plurality of shapes and sizes.... Agent: Seyfarth Shaw, LLP

20080166792 - Detection of analytes in materials liquids using capillary colorimetric detection: Systems and methods for the rapid and reliable detection of analytes in liquid solutions such as water, drinking fluids, extracts of solids such as foods, soils, industrial fluids such as oils, cooling water, fuels, solutions of drugs or chemicals, etc. The systems preferably include an inexpensive and disposable capillary containing... Agent: Intellectual Property / Technology Law

20080166793 - Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture: A system for identifying all of the known and unknown pathogenic or non-pathogenic organisms in a sample. A droplet generator creates droplets from the sample. The droplets constitute sub-nanoliter volume reactors containing the organism sized particles. A lysis device performs lysis of the organisms to release the nucleic acids. An... Agent: Eddie E. Scott Assistant Laboratory Counsel

20080166794 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati

20080166795 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati

20080166796 - Device for cell culture on deformable surfaces: Device for the in vitro culture of cells comprising: a planar deformable substrate (3) with a culture surface (4), substrate deforming means for modifying the size of said culture surface (4), characterized by the fact that it furthermore comprises: substrate holding elements (5) which are located near the periphery of... Agent: Nixon & Vanderhye, PC

20080166797 - Adenovirus vectors containing cell status-specific response elements and methods of use thereof: The present invention provides adenoviral vectors comprising cell status-specific transcriptional regulatory elements which confer cell status-specific transcriptional regulation on an adenoviral gene. A “cell status” is generally a reversible physiological and/or environmental state. The invention further provides compositions and host cells comprising the vectors, as well as methods of using... Agent: Ropes & Gray LLP

20080166801 - Filtration system and method for obtaining a cytology layer: A filter assembly for separating and collecting a layer of particulate matter (e.g., cells) from a liquid containing the particulate matter (e.g., a biological fluid specimen). The filter assembly has a holder and contiguous inner and outer fluid pervious media. The outer fluid pervious medium is attached to the sidewall... Agent: Foley And Lardner LLP Suite 500

20080166799 - Fluorescent protein: f

20080166800 - Method and medicament for inhibiting the expression of a given gene: The invention relates to an isolated RNA that mediates RNA interference of an mRNA to which it corresponds and a method of mediating RNA interference of mRNA of a gene in a cell or organism using the isolated RNA.... Agent: Lowrie, Lando & Anastasi, LLP A2038

20080166798 - Trimerizing polypeptides and their uses: A method for trimerizing collagenous molecule monomers comprising the step of contacting a collagen domain and a non-collagenous trimerization domain is provided. In addition, methods of trimerizing heterologous peptides is provided. Trimerizing polypeptides, vectors, cells, and trimerized polypeptides are also provided.... Agent: Sonnenschein Nath & Rosenthal LLP

20080166802 - Human antibodies specific for interleukin 15 (il-15): Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing... Agent: Lahive & Cockfield, LLP

20080166803 - Novel cell-based assays employing voltage and calcium dyes: Disclosed are novel compositions and methods employing cyclic nucleotide-gated channels and fluorescence dyes and other indicators in detecting changes of intracellular cAMP levels, for instance in response to the stimulation of G-protein-coupled receptors. CNG mutants comprising one or more pore mutations that enhance sensitivity to cAMP and decrease divalent cation-mediated... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080166804 - Compostions and methods for growing human embryonic stem cells: Methods for deriving and cultivating human embryonic stem (ES) cells and maintaining their pluripotency in culture is provided by utilizing secreted products obtained from the culture medium of human embryonic germ (EG) cell derivatives, such as embryoid body-derived cells. Substrates include compounds such as collagen I, fibronectin, or superfibronectin, or... Agent: Pearl Cohen Zedek Latzer, LLP

20080166805 - Culturing human cells and tissues in an n-glycolylneuraminic acid-free environment: This application is in the field of sialic acid chemistry, metabolism, antigenicity, and the production of transgenic non-human mammals with altered sialic acid production. More particularly, this application relates to N-glycolylneuraminic acid (Neu5Gc) being an immunogen in humans, and the production of Neu5Gc-free mammalian products for laboratory and human use.... Agent: Buchanan, Ingersoll & Rooney LLP

20080166806 - Attenuated effector ligand: Methods and compositions are provided for effecting physiological processes using a conjugate of a binding member binding to a surface membrane marker and a ligand for a cell surface receptor, where the ligand is attenuated as compared to the natural ligand. The composition finds particular application in discriminating between cells... Agent: Mark Wehrman

20080166807 - Autologous progenitor stem cells of gastrointestinal origin: This invention relates to the discovery of autologous stem cells of gastrointestinal origin in fecal matter. More particularly, the invention relates to the isolation and propagation of said stem cells in continuous culture. Furthermore, the invention describes a method of directing and converting these gastrointestinal progenitor stem cells into immunoglobulin... Agent: Mishrilal Jain

20080166808 - Bioartificial liver system: A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are also described for forming spheroid aggregates from isolated hepatocytes.... Agent: Fish & Richardson P.C.

20080166809 - Method of inducing genome reorganization via intracellular activation of thermostable multifrequency dna-cleaving enzyme: The present invention relates to a method for increasing genetic recombination frequency in a genomic DNA and a method for inducing genome rearrangement. Specifically, according to the present invention there are provided: the method for increasing genetic recombination frequency in a cell in which genetic recombination takes place at any... Agent: Bozicevic, Field & Francis LLP

20080166810 - Systems for genome selection: Systems, methods, compositions and apparatus relating to genome selection are disclosed.... Agent: Searete LLC Clarence T. Tegreene

20080166811 - Site-specific recombination system to manipulate the plastid genome of higher plants: A site specific recombination system and methods of use thereof are disclosed for manipulating the genome of higher plants.... Agent: Dann, Dorfman, Herrell & Skillman

20080160496 - Preserved viable cartilage, method for its preservation, and system and devices used therefor: The present invention provides methods for providing cartilage-containing tissue for grafting, comprising providing excised cartilage-containing tissue; and treating said excised cartilage-containing and cryogenically preserving the treated cartilage-containing tissue under appropriate cryogenic preservation conditions so as to yield cryogenically preserved cartilage-containing tissue having at least 10% viable chondrocytes throughout the cartilage... Agent: Nath & Associates

20080160498 - Gel microdrops in genetic analysis: The invention provides methods of nucleic acid analysis. Such methods entail forming a population of gel microdrops encapsulating a population of biological entities, each entity comprising a nucleic acid, whereby at least some microdrops in the population each encapsulate a single entity. The population of gel microdrops is then contacted... Agent: Townsend And Townsend And Crew, LLP

20080160497 - Methods and systems for determining mid-value titers: The invention provides methods for determining the mid-value titer of a substance in a composition. In some methods the substance comprises at least one anti-hemagglutinin (HA) antibody. The invention also provides systems and computer-readable media for use in association with such methods.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080160504 - Breath test: A method of assessing the state of the lining of the small intestine in a mammal or human injesting a suitable labelled test substrate which requires conversion by a brush border enzyme for transport across the small intestinal lining. Suitable substrates include sucrose and maltose. The transport of these can... Agent: Knobbe Martens Olson & Bear LLP

20080160505 - Diagnostic methods for age related macular degeneration: Diagnostic methods for identifying a test subject who has or is at risk of developing age-related macular degeneration (AMD) or an analogous disease associated with oxidation of DHA-containing lipids are provided. In one aspect, the methods comprise: assaying for the presence of elevated levels of 2-(ω-carboxyethyl) pyrrole (CEP) adducts in... Agent: Calfee Halter & Griswold, LLP

20080160506 - Immunological analytical method and device for the determination of advanced glycosylation end products (ages): The invention provides an immunological analytical method and devices for determination of the advanced glycosylation end products (AGEs), comprising a reagents for determining the AGEs, which comprises a displaying carrier suspension and the antigen or antibody immobilized on the surface of the said displaying carrier; and a test strip, comprising... Agent: Bacon & Thomas, Pllc

20080160500 - Low volume assay apparatus and method: Apparatus and method for analysing a biological fluid sample to determine a disturbance of haemostasis resulting in a change of viscosity.... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080160499 - Non-denaturing lysis reagent: The invention provides a lysis reagent and method for preparing a test sample for use in an assay, wherein the method yields a homogeneous lysis mixture suitable for use in automated pipetting systems without the need for a centrifugation step. The lysis reagent includes a glycol and an alcohol. Other... Agent: Beyer Weaver LLP

20080160501 - Plasma protein-binding ligands: The invention provides an isolated or purified peptide that binds at least one plasma protein. In one embodiment, the isolated or purified peptide binds to fibrinogen, comprises no more than 10 amino acids, and comprises an amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5, and amino acid sequence Gly-Xaa6-Arg-Xaa7, or an amino acid sequence... Agent: Merchant & Gould Pc

20080160502 - Portable biological testing device and method: A device and method for providing portable biological testing capabilities free from biological contamination from an environment outside the device are provided. The device includes a portable housing. The device further includes a volume surrounded by the housing and sealed against passage of biological materials between the volume and the... Agent: Knobbe Martens Olson & Bear LLP

20080160503 - Rapid analysis of oral bioavailability: Provided herein are procedures for rapidly determining oral bioavailability of two or more compounds by administering the two or more compounds to an animal, extracting fluid from an eye region of the animal and determining the amount of each of the two or more compounds in the fluid by mass... Agent: Morrison & Foerster LLP

20080160508 - Assay method and assay kit for virus respiratory infection: An assay method for virus respiratory infection, is provided with steps of: providing a first immunochromatographic test device for assaying a first virus respiratory infection, and a second immunochromatographic test device for assaying a second virus respiratory infection different from the first virus respiratory infection; preparing an assay sample by... Agent: Sughrue Mion, Pllc

20080160509 - Assays for predicting and assessing predisposition to male pattern baldness: A method of predicting the likelihood that a subject will develop alopecia, a method for identifying an individual as a candidate for treatment of androgenetic alopecia, a method for identifying a male subject infected with HSV as a candidate for treatment of androgenetic alopecia, a method of managing a treatment... Agent: Christensen, O'connor, Johnson, Kindness, Pllc

20080160507 - Hiv capsid assembly-associated compositions and methods: A cell-free method for translation and assembly of retroviral, particularly HIV, capsid and capsid intermediates is disclosed. Also disclosed are novel HIV capsid assembly intermediates and novel host proteins which bind to such assembly intermediates. The invention also includes a screening method for compounds that alter retrovirus capsid assembly, and... Agent: Quine Intellectual Property Law Group, P.c.

20080160534 - Altering memory by affecting staufen: The present invention provides cell-based screening methods for identifying pharmaceutical agents which are capable of modulating (have the ability to modulate) STAUFEN function by screening for STAUFEN function.... Agent: Heller Ehrman LLP

20080160533 - Assay for prediction of response to met antagonists: A method for classifying cancer patients as likely to have lower response to MET receptor antagonist therapy comprises assessment of the presence or absence of a single nucleotide polymorphism in the MET promoter in a patient tissue sample. The invention provides more effective identification of patients to receive MET receptor... Agent: Vysis, Inc Patent Department

20080160523 - Association of single nucleotide polymorphisms, dairy form and productive life: The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention relates to the identification of a single nucleotide polymorphisms (SNPs) within the... Agent: Frommer Lawrence & Haug

20080160521 - Benzimidazolium dyes and their use as fluorescent chemosensors: R is (aromatic)o-(linker)p-with the linker being saturated or unsaturated C1-C5 hydrocarbons, each aromatic independently being a substituted or unsubstituted aromatic or heteroaromatic, o being 1 or 2, and p being 0 or 1. Methods of making and using these compounds are also disclosed.... Agent: Nixon Peabody LLP - Patent Group

20080160516 - Capture and detection format versatility for dipstick assays: Dipsticks for testing for the presence of a target nucleic acid in a sample solution are described the dipsticks comprise a universal capture probe immobilised at a capture zone of the dipstick. The universal capture probe is capable of hybridising to a hook capture probe which is hybridised to the... Agent: Proskauer Rose LLP

20080160513 - Characterization of mcra subunits and uses thereof: Compositions and methods are provided in which the composition is a protein with at least 50% but less than 100% amino acid sequence identity with McrA or is a variant McrA protein with at least one amino acid sequence modification. The variant or protein has the property of cleaving DNA... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20080160519 - Depression gene: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human depression predisposing gene, specifically the apoptotic protease activating factor 1 (APAF1) gene, some mutant alleles of which cause susceptibility to depression. More specifically,... Agent: Knobbe Martens Olson & Bear LLP

20080160514 - Enzymatic treatment of pulp: Carbon dioxide is used to adjust the pH of cellulosic pulp or biomass to 6.5 to 7.5 prior to or during the application of enzymes to and the interaction of the enzymes with the cellulosic pulp. The carbon dioxide is applied as a gas into a pulp stream or biomass... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

20080160530 - High throughput genome specific molecular markers for erucic acid content genes in brassica napus: A single base change in the Bn-FAE1.1 gene in the A genome and a two-base deletion in the Bn-FAE1.2 gene in the C genome produce the nearly zero content of erucic acid observed in canola. A BAC clone anchoring Bn-FAE1.1 from a B. rapa BAC library and a BAC clone... Agent: Ade & Company Inc.

20080160525 - Method and device for detecting the presence of a single target nucleic acid in a sample: A method comprises loading a sample portion into a first porous structure, subjecting the sample portion to an amplification step, and determining whether the sample portion contains at least one molecule of a target nucleic acid. If the sample portion contains a single molecule of the target nucleic acid, the... Agent: Burr & Brown

20080160511 - Method and substances for isolating mirnas: A capture probe suitable for use with a method for isolating miRNAs. A method for isolating an miRNA of interest from a sample comprising the miRNA of interest comprising providing the capture probe. A method for identifying an miRNA of interest.... Agent: Sheldon Mak Rose & Anderson Pc

20080160512 - Method for rapid detection and identification of bioagents: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent.... Agent: Casimir Jones, S.c.

20080160510 - Method of detecting carcinogenesis caused by hepatitis b virus: A method for detecting, in liver tissue isolated from a human subject and suspected of being cancerous, integration of HBV-DNA into the MLL4 gene, this integration of HBV-DNA indicating the cancerous nature of a tissue. In a typical case, this integration can be detected by carrying out PCR using a... Agent: Sughrue Mion, Pllc

20080160517 - Method of determining a chemotherapeutic regimen by assaying gene expression in primary tumors: The invention relates to a method for determining a chemotherapeutic regimen for an individual, comprising obtaining a mRNA sample from a primary tumor specimen; determining a gene expression level for a tumor gene determinant in the specimen; comparing the gene expression level for the tumor gene determinant with a predetermined... Agent: Kenyon & Kenyon LLP

20080160520 - Methods and composition for diagnosing and treating cancer: The present invention provides methods of detecting and treating cancer.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080160524 - Methods and compositions for detecting target sequences: The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for amplifying a synthetic DNA from a target nucleic acid, forming a nucleic acid cleavage structure on the synthetic DNA, and... Agent: Casimir Jones, S.c.

20080160529 - Methods and compositions for nucleic acid analysis: The present invention relates to improved methods and composition for nucleic acid analysis. In particular, the present invention provides improved methods and compositions for carrying out nucleic acid analysis using modified nucleotides.... Agent: Casimir Jones, S.c.

20080160535 - Methods and reagents for detecting target binding by nucleic acid ligands: The present invention provides novel methods and reagents for detecting the binding of protein targets to nucleic acid ligands. Using Universal Protein Stains (UPS), proteins bound by nucleic acid ligands may be labeled with a detectable moiety. The methods and reagents are particularly useful for the detection of protein targets... Agent: Swanson & Bratschun, L.l.c.

20080160526 - Mismatched end dna ligase: A mismatched end DNA ligase is provided, which ligates two single strands to each other at a high efficiency, even if the other two single strands are not compatible. In one embodiment, the polypeptides of the ligase are Ku, Cernunnos, and XRCC4/Ligase4 (XL). This association can ligate DNA ends with... Agent: Bozicevic, Field & Francis LLP

20080160532 - Nucleic acid probes and methods for detecting plasmodium parasites: This invention relates to novel nucleic acid probes and methods for detecting Plasmodium parasites as well as detecting different Plasmodium parasites selectively from one another.... Agent: Kevin M. Farrell Pierce Atwood

20080160527 - One-tube nested pcr for detecting mycobacterium tuberculosis: The present invention relates to a kit and method for detecting M. tuberculosis of suspected patient. The present invention also relates to primers and probe used to detect M. tuberculosis by performing one tube nested PCR.... Agent: Dougherty & Troxell One Skyline Place

20080160522 - Primer for detecting food poisoning and method for rapid detection of food born pathogene: The present invention relates to a primer of detecting a food-borne pathogen, and to a method of detection for food poisoning. In particular, the invention relates to a PCR primer which is specific to and is used for rapid and accurate detection of the Salmonella spp., Staphylococcus aureus, E. coli... Agent: Lexyoume Ip Group, Llc

20080160518 - Tracer reagents that enhance reaction-product analysis: A composition suitable for formulation of an enzymatic reaction mixture, the composition comprising a reaction component essential for an ex-vivo non-polymerase enzymatic reaction in which a substrate is catalyzed by an enzyme in a reaction mixture to form a product, and a tracer compatible with the enzyme, the composition being... Agent: Senniger Powers LLP

20080160531 - Uniform surfaces for hybrid material substrates and methods for making and using same: Devices, systems and methods of using same where hybrid substrate materials are provided with a substantially uniform surface to provide uniformity of properties, including interaction with their environments. Uniform surfaces are applied as coatings over, e.g., hybrid metal/silica, metal/polymer, metal/metal surfaces to mask different chemical properties of differing regions of... Agent: Morgan, Lewis & Bockius LLP (sf)

20080160515 - Use of c3a and derivatives thereof as a biomarker for colorectal adenoma and/or carcinoma; method for detection and test system: The present invention is directed to a method for detecting colorectal adenoma and/or colorectal carcinoma comprising the steps: a) providing an isolated sample material which has been taken from an individual, b) determining the level of C3a or a derivative thereof in said isolated sample material, c) comparing the determined... Agent: Raymond J Lillie Carella Byrne Bain Gilfillan

20080160528 - Use of nucleases for degrading nucleic acids in the presence of chaotropic agents and/or surfactants: The invention relates to the use of nucleases, especially DNA-degrading nucleases, for degrading nucleic acids in the presence of one or several chaotropic agents and/or one or several surfactants. The invention further relates to a method for purifying RNA from mixtures of DNA and RNA as well as kits for... Agent: Nixon & Vanderhye, Pc

20080160538 - Lateral flow test kit and method for detecting an analyte: A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.... Agent: Charm Sciences, Inc. Attn: Richard J. Long

20080160536 - Methods for detecting calcium ion influx: A method for detecting influx of calcium ions into a eukaryotic cell comprising providing a eukaryotic cell having a detectable reporter capable of translocation from the cytosol to associate with the plasma membrane in response to an influx of calcium ions, and, monitoring association of the detectable report with the... Agent: Goodwin Procter LLP Patent Administrator

20080160541 - Methods of screening compounds inhibiting signal transduction through inflammatory cytokines: Revealed are that the actions of inflammatory cytokine and the production of inflammatory cytokines such as IL-1 and TNF induced by an inflammatory stimulus as well as the production of other inflammatory cytokines such as IL-6 induced by the former class of inflammatory cytokines are all suppressed by inhibiting the... Agent: Fish & Richardson Pc

20080160537 - Particle based binding assay: The present invention provides a method for detecting the presence or amount of an analyte in a sample, said method comprising: a porous surface to which particles having attached thereto a binding substance, analyte and binding substance coated label particles are added. If said analyte is present in the sample... Agent: Clark & Elbing LLP

20080160540 - Polypeptides related to natriuretic peptides and methods of their identification and use: The present invention relates to the identification and use of polypeptides that bind to antibodies directed to a desired polypeptide of interest. Using natriuretic peptides and their precursors, and in particular BNP, as an example, the present invention describes a number of natriuretic peptides fragments produced in biological samples, most... Agent: Townsend And Townsend And Crew, LLP

20080160539 - Substrates, devices, and methods for cellular assays: The present invention relates to the field of molecular diagnostics. In particular, the present invention provided improved substrates and methods of using liquid crystals and other biophotonically based assays for quantitating the amount of an analyte in a sample. The present invention also provides materials and methods for detecting non-specific... Agent: Casimir Jones, S.c.

20080160542 - Method for activating an antigen, method for detecting a cell, and solution for activating an antigen: A method of activating an antigen is herein described. The method comprises providing an antigen activation solution and contacting the cell with the solution to activate the antigen. A method of detecting a cell fixed by a nonbridging fixation solution is also described. The method comprises providing an antigen activation... Agent: Sughrue Mion, Pllc

20080160544 - High throughput assay of hematopoietic stem and progenitor cell proliferation: The present invention relates generally to kits that provide reagent mixes and instructions for the use thereof, in performing high-throughput assay methods that determine the proliferative status of isolated target cell populations. The methods measure the luminescent output derived from the intracellular ATP content of incubated target cells, and correlate... Agent: Rosenbaum & Associates, P.c.

20080160546 - Methods and marker combinations for screening for predisposition to lung cancer: The present invention relates to rapid, sensitive methods for determining whether a subject is at risk of developing lung cancer or has lung cancer based on certain combinations or biomarkers or biomarkers and biometric parameters.... Agent: Paul D. Yasger Abbott Laboratories

20080160545 - Pro-grp as a surrogate marker to predict and monitor response to bcl-2 inhibitor therapy: A method for classifying cancer patients as eligible to receive cancer therapy with a Bcl-2 inhibitor comprising determination of the presence or absence in a patient tissue sample of levels of pro-GRP, as a surrogate marker for the presence of chromosomal copy number gain at chromosomal locus 18q21-q22. The classification... Agent: Vysis, Inc Patent Department

20080160543 - Electrochemical immunostrip and its preparation method: An electrochemical immuno diagnostic strip and its preparation method are disclosed herein. A screen-printed electrode is prepared on an insulating substrate, which is divided into an electrode area and a connecting area. An electrochemical precursor is placed on the electrode area and a reaction membrane is provided on the electrode... Agent: Rosenberg, Klein & Lee

20080160548 - Microoptical detection system and method for determination of temperature-dependent parameters of analytes: The invention relates to a microoptical detection system and a method for detecting analytes by means of time-resolved luminescence. This serves for determination of temperature-dependent parameters of analytes, in particular for determination of point mutations of nucleic acids (DNA), for which a time-resolved detection is required.... Agent: Leydig Voit & Mayer, Ltd

20080160549 - Immunochromatography kit: An immunochromatography kit including an inorganic silver salt or a silver complex, a reducing agent for silver ions, and a metal colloid label or a metal chalcogenide label. The immunochromatography kit uses an immune reaction of an analyte and an antibody or antigen that can specifically bind to the analyte,... Agent: Birch Stewart Kolasch & Birch

20080160553 - Method of preparing heart muscle cells and method of searching for remedy for heart diseases: The present invention relates to a method of preparing primary heart muscle cells, characterized by washing a fine fragmented heart tissue with a phosphate-buffered physiological saline to thereby eliminate non-heart muscle cells and then hemolyzing the heart tissue digested with a protease to thereby eliminate erythrocytes. According to this method,... Agent: Edwards Angell Palmer & Dodge LLP

20080160552 - Methods and compounds for treating inflammation: The invention relates in embodiments to methods for identifying compounds that inhibit phosphorylation of GD-1, to compositions comprising such inhibitors, including pharmaceutical compositions, and to the use of such inhibitors and compositions to treat diseases, such as inflammatory diseases.... Agent: Larry S. Millstein Holland & Knight LLP

20080160551 - Microorganisms and assays for the identification of antibiotics: The present invention features methods for the identification of compounds and compositions useful as antibiotics and antibacterial agents. In particular, the invention features methods for the identification of modulators of a previously unidentified target protein, termed CoaX. High-throughput assay systems are featured as well as assay kits for the identification... Agent: Lahive & Cockfield, LLP

20080160550 - Monitoring enzyme-substrate reactions: Methods of electrochemically monitoring enzyme-substrate reactions are described. The substrate is tagged with a redox-active group. Modification of the substrate by an enzyme can then be monitored electrochemically by means of the redox-active group. Such methods can be used in particular to monitor non-redox enzyme reactions, such as kinase, phosphatase,... Agent: Seed Intellectual Property Law Group Pllc

20080160554 - Methods for diagnosing bipolar disorders and attention-deficit/hyperactivity disorder: Changes that occur in Na+K+ ATPase regulation and therefore in the membrane potential in cells from bipolar individuals, as compared to cells from unaffected control individuals, are utilized to provide a diagnostic assay for bipolar I and bipolar II disorders. The diagnostic assay may also or instead exploit the similarity... Agent: Sughrue Mion, Pllc

20080160555 - Detecting a microorganism strain in a liquid sample: The invention concerns a medium for detecting, identifying and differentiating a microorganism strain in a liquid medium by contacting said liquid sample with a combination of chromogens substrates of enzymes expressed or not by the strain to be detected, the final coloration of the mixture being detectable in the wavelengths... Agent: Alston & Bird LLP

20080160556 - Bioassay element and producing method thereof: The present invention relates to a low-priced bioassay element, comprising: a carrier comprising a porous cellulose filter paper and a stationary layer, wherein said stationary layer comprises casein and calcium ions, and covers on said porous cellulose filter paper; a coating film comprising casein and calcium ions, which covers on... Agent: Bacon & Thomas, Pllc

20080160557 - Diagnostic test for head and facial pain: A diagnostic test for head and facial pain includes providing a series of antibodies to several biological markers on a test strip, collecting a sample of saliva, and applying the saliva sample to the series of antibodies. If one or more of the anticipated biological markers are present in the... Agent: Husch Blackwell Sanders LLP

20080160558 - Process for generating sequence-specified proteases by directed evolution and use thereof: A process for generating sequence-specific proteases by screening-based directed evolution is disclosed. The use of the process provides proteases recognizing and cleaving user-definable amino-acid sequences with high sequence-specificity. Proteases obtainable by the process can be used in a variety of medical, diagnostic and industrial applications.... Agent: Norris, Mclaughlin & Marcus, Pa

20080160564 - High throughput assay for identifying compounds capable of modulating the proliferative status of stem cells: The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to high-throughput assays for screening compounds that modulate the growth of hematopoietic stem and progenitor cells and for identifying subpopulations thereof that are suitable for... Agent: Rosenbaum & Associates, P.c.

20080160563 - High throughput stem cell assay for identifying stem cells useful for transplantation: The present invention relates generally to high-throughput assay methods that determine the proliferative status of hematopoietic stem and progenitor cells. The present invention further relates to high-throughput assays for screening compounds that modulate the growth of hematopoietic stem and progenitor cells and for identifying subpopulations thereof that are suitable for... Agent: Rosenbaum & Associates, P.c.

20080160560 - In vitro resveratrol-rich callus tissues derived from vitis thunbergii sieb.et zucc and method for producing the same: The present invention provides an in vitro resveratrol-rich callus tissue of Vitis thunbergii Sieb. et Zucc. which is a callus tissue developed from a tissue culture system containing one or more plant growth regulators (PGRs) and cultured from a stem or a petiole tissue explant of a wild type of... Agent: Andrews Kurth LLP Intellectual Property Department

20080160561 - Lipophilic dye-based fret assays for clostridal toxin activity: Compositions useful for detecting Clostridial toxin activity comprising a cell that comprises a membrane-associated Clostridial toxin substrate comprising a first member of a fluorescence resonance energy transfer pair; and a Clostridial toxin recognition sequence including a cleavage site; and a membrane-associated second member of the FRET pair and methods useful... Agent: Allergan, Inc.

20080160562 - Method for assessing arteriosclerosis and diabetic nephropathy: A method for assessing arteriosclerosis comprising measuring the serotonin level in whole blood, serum or platelet-rich plasma and rating the serotonin level on such a scale that the lower it is, the more serious the arteriosclerosis is.... Agent: Sughrue Mion, Pllc

20080160559 - Thermo-responsive blends and uses thereof: Described herein are thermo-responsive blends. Also described herein are articles, substrates, and kits composed of thermo-responsive blends for immobilizing cells or tissue and methods of use thereof.... Agent: Corning Incorporated

20080160565 - Human abo blood group-binding lactobacilli: Lactobacillus screening methods were carried out using surface plasmon resonance spectrums and human intestinal mucin and blood group antigens as probes. A trial to set selection criteria in the above-mentioned methods of screening for lactobacilli was made to adapt the methods to mass screening, and it was discovered that lactobacilli... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080160566 - Method, device and system for volumetric enumeration of white blood cells: A sample acquiring device for volumetric enumeration of white blood cells in a blood sample comprises a measurement cavity for receiving a blood sample. The measurement cavity has a predetermined fixed thickness. The sample acquiring device further comprises a reagent, which is arranged in a dried form on a surface... Agent: Buchanan, Ingersoll & Rooney Pc

20080160567 - Bacterial poly(hydroxy alkanoate) polymer and natural fiber composites: A biocomposite is produced from natural fiber fabrics embedded in a matrix of biosynthetic polyhydroxy-alkanoate (PHA) polymers. The PHA is synthesized using aerobic microbial biosynthesis using mixed bacterial cultures and a feedstock containing anaerobic degradation products such as methane and volatile fatty acids derived from microbial biodegradation of organic waste... Agent: Lumen Patent Firm, Inc.

20080160568 - Automated process for performing consecutive reaction involving weighting of material: This invention relates to an automated process for performing two or more consecutive reactions in a reaction vessel, said reaction vessel comprising an outlet at the base of said reaction vessel, and said process comprising: i) performing a first reaction is said reaction vessel, said first reaction comprising reacting one... Agent: Nixon & Vanderhye, Pc

20080160569 - Stable biodegradable, high water absorbable polyglutamic acid hydrogel by 3-dimensional cross-linking and its preparation method: i

20080160572 - Aminopeptidase: A gram-negative bacterial cell is described that is deficient in a chromosomal gene present in a wild-type such cell which gene shares at least 80% sequence identity with the native sequence of the yfcK gene and encodes an aminopeptidase. Alternatively, a gram-negative bacterial cell is deficient in a chromosomal gene... Agent: Genentech, Inc.

20080160571 - Antibodies that bind tnf-alpha converting enzyme: A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof,... Agent: Immunex Corporation Law Department

20080160574 - Chimeric coiled coil molecules: The present application describes a fusion molecule that includes coiled coil domain, which renders the molecule soluble and provides potent activity.... Agent: Jhk Law

20080160570 - Method for production of recombinant growth hormone in form of hybrid protein: A method of producing somatotropin encompassing the microbiological expression of a recombinant protein containing somatotropin and hybrid polypeptide containing the amino-acid sequence of ubiquitin and the amino-acid sequence of somatotropin.... Agent: Paul Lunn, Esq.

20080160573 - Mutant alpha-amylases: Novel variant α-amylase enzymes are disclosed in which the residues corresponding to R179 and G180 in Bacillus stearothermophilus (SEQ ID NO.2) are deleted. The disclosed variant α-amylase enzymes show altered or improved stability and/or activity profiles.... Agent: Genencor International, Inc.

20080160575 - Method for producing protein: By culturing a methanol-assimilating bacterium which harbors a DNA construct which contains a promoter sequence that functions in the methanol-assimilating bacterium and a nucleotide sequence that encodes a polypeptide containing a signal sequence and an objective protein which is functionally connected to the promoter sequence, in a liquid medium containing... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080160576 - Anti-alphabeta3 humanized monoclonal antibodies: This invention relates to novel humanized and other recombinant or engineered antibodies or monoclonal antibodies to the vitronectin αvβ3 receptor and to the genes encoding same. Such antibodies are useful for the therapeutic and/or prophylactic treatment of αvβ3-mediated disorders, such as restenosis, in human patients.... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20080160577 - Optimization of heterologous polypeptide expression: This invention relates to methods for controlling deamidation of at least one type of heterologously expressed polypeptide in cell culture.... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20080160578 - Production of recombinant proteins in synthetic medium: The invention relates to a method for the production of recombinant proteins by eucaryotic cells in synthetic culture media, wherein said eucaryotic cells are transfected with a composition comprising a synthetic transfection reagent based on a polyhydroxylated polyalkyleneimine.... Agent: Nixon & Vanderhye, Pc

20080160580 - Methods of nucleic acid amplification and sequencing: Methods for amplification and sequencing of at least one nucleic acid comprising the following steps: (1) forming at least one nucleic acid template comprising the nucleic acid(s) to be amplified or sequenced, wherein said nucleic acid(s) contains at the 5′ end an oligonucleotide sequence Y and at the 3′ end... Agent: Klauber & Jackson

20080160581 - Methods for amplification of nucleic acid sequences using promoter templates: Methods and kits are provided for producing sense RNA molecules. The sense RNA molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20080160582 - Isomaltulose synthases, polynucleotides encoding them and uses therefor: The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose isomerases, methods for isolating such polynucleotides and nucleic acid constructs that express these polynucleotides. Also disclosed are cells, including transformed bacterial or plant cells, and... Agent: Proskauer Rose LLP

20080160584 - Alpha-agarase and process for producing the same: A polypeptide having an α-agarase activity, a gene encoding the polypeptide, a method for producing the polypeptide by genetic engineering and a method for producing an agarooligosaccharide using the polypeptide.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080160583 - Process for co-fermentation of phellinus linteus fungus with chinese herbal medicines: The present invention relates to a process of fermenting a strain of Phellinus linteus fungus, in which the fungus is incubated in a medium under the condition for the best yield control with the aim to obtain the best yield of mycelia and polysaccharides, where the best ratio of the... Agent: Kamrath & Associates P.a.

20080160585 - Methods for the preparation of lysine by fermentation of corynebacterium glutamicum: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of... Agent: Lahive & Cockfield, LLP

20080160586 - Process for the purification of tacrolimus: A process for the purification and recovery of Tacrolimus (I) (17-allyl-1,14-dihydroxy-12-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methyvinyl]-23,25- dimethoxy-13,19,21,27-tetramethyl-11,28-dioxi-4-azatricyclo-[22.3.1.04.9]octacos-18-en-2,3,10,16-tetraone), starting from Streptomyces sp fermentation broth. The process is particularly advantageous in terms of productivity and selectivity of the separation of impurities.... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080160587 - Stemphones and production thereof: The present invention relates to novel stemphones having enhancing effect of β-lactam antibiotic used as an antibacterial agent, and a process for production thereof. The process is comprised of culturing microorganism belonging to genus Aspergillus and having ability to produce stemphones, the microorganism of which is Aspergillus sp. FKI-2136 NITE... Agent: Young & Thompson

20080160588 - Alcohol dehydrogenase gene from gluconobacter oxydans: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, Pc

20080160589 - Gene rcs 24: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, Pc

20080160590 - Salt formulations for the fermentation of marine microorganisms: Growth medium are disclosed for use in fermenting a marine microorganism. The medium comprise Potassium, Calcium, Strontium, Borate and Fluoride at specific concentrations. Alternatively, the growth medium comprises cobalt at specified concentrations or comprises vitamin B12 at specified concentrations. Methods of producing certain desired compound by fermentation of a marine... Agent: Knobbe Martens Olson & Bear LLP

20080160591 - Diffuse light extended surface area water-supported photobioreactor: A scalable photobioreactor system for efficient production of photosynthetic microorganisms such as microalgae and cyanobacteria is described. In various embodiments, this system may include the use of extended surface area to reduce light intensity and increase photosynthetic efficiency, an external water basin to provide structure and thermal regulation at low... Agent: Faegre & Benson LLP Patent Docketing

20080160592 - Class of enzymes in the biosynthetic pathway for the production of triacylglycerol and recombinant dna molecules encoding these enzymes: The present invention relates to the isolation, identification and characterization of nucleotide sequences encoding an enzyme catalysing the transfer of fatty acids from phospholipids to diacylglycerol in the biosynthetic pathway for the production of triacylglycerol, to the said enzymes and a process for the production of triacylglycerols.... Agent: Novak Druce Deluca + Quigg LLP

20080160593 - Two-stage process for producing oil from microalgae: A process for production of biofuels from algae can include cultivating an oil-producing algae by promoting sequential photoautotrophic and heterotrophic growth. The method can further include producing oil by heterotrophic growth of algae wherein the heterotrophic algae growth is achieved by introducing a sugar feed to the oil-producing algae. An... Agent: Thorpe North & Western, LLP.

20080160594 - Methods of light activated release of ligands from endosomes: Methods for delivering ligands to a cell by using light to activate fluorescent ligands causing their release from endosomes. The instant methods thus increasing the efficiency of ligands, e.g. in vitro or at localized sites within a subject. The invention provides for the release of ligands by shining a light... Agent: Invitrogen Corporation C/o Intellevate

20080160595 - Nematode atp synthase subunit e-like sequences: Nucleic acid molecules from nematodes encoding ATP synthase subunit E polypeptides are described. ATP synthase subunit E-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of ATP synthase subunit E-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators,... Agent: Fish & Richardson Pc

20080160596 - Artificial biomembrane and the method for manufacturing the same: The present invention relates to an artificial biomembrane and a method for manufacturing such an artificial biomembrane. The beneficial microbial strains, authorized for use in the nation, are concentrated after fermentation. Film-forming raw materials in the water, such as polyvinyl alcohol, sodium alginate and sodium carboxymethyl cellulose, are dissolved into... Agent: Matthias Scholl

20080160597 - Method and apparatus for cultivating cells utilizing wave motion: During said swivelling of the container said pivot axis follows a cyclical closed-loop path. Also provided is an apparatus for performing said method, and an assembly for said method. Further part of the invention are disposable bags for cell or bacterial culture of which the volume can be changed in... Agent: Banner & Witcoff, Ltd.

20080160598 - Organic monolith reactor and the preparation method thereof: In an organic monolith reactor according to the present invention, a horseradish peroxidase is embedded onto a microscopic area with a photopolymerized polymer. The method of preparing an organic monolith reactor according to the present invention comprises (a) dispersing a horseradish peroxidase in a mixed solution of a photopolymerizable monomer... Agent: Flynn Thiel Boutell & Tanis, P.c.

20080160599 - Unit for processing microbiological samples: A unit for processing microbiological samples has a conveyor for transporting samples, for example in microtitre plates. At a processing station, samples for processing are transferred in their sample containers from the transport device to a processing device, which can have several processing areas, of which only one is ever... Agent: Duane Morris, LLP Ip Department

20080160601 - Heater unit for microfluidic diagnostic system: The present technology provides for a heater substrate that contains networks of heater elements configured to controllably and selectively deliver heat to one or more PCR reaction chambers in a microfluidic substrate with which the heater substrate makes contact. In exemplary embodiments, the heater substrate can deliver heat to 12,... Agent: Fish & Richardson P.c.

20080160602 - Microcolumn-based, high-throughput microfluidic device: A biological assay device for use in molecular biology, pharmaceutical research, genomic analysis, combinatorial chemistry, and in the general field of the analysis of molecules that may be deposited on supports of various kinds is provided. Specifically, the present invention includes a fluidic or microfluidic device, which integrates fluidic capability... Agent: Corning Incorporated

20080160600 - Rapid monitoring system for blood groups and immunohematological reaction detection: A system for monitoring blood groups and for detecting immunohematological reactions uses a detection device consisting of a quartz crystal microbalance (QCM), a device able to measure very small variations in mass (down to fractions of a nanogram).... Agent: Greenberg Traurig LLP (la)

20080160603 - Flow stabilization in micro-and nanofluidic devices: Embodiments of the present invention provide microfluidic devices having deformable polymer membranes as components. The devices can be fabricated from a single polymeric block. Actuation of the membranes within the device allows the fluid contained within a microfluidic channel to be manipulated. Exemplary microfluidic devices, such as, peristaltic pumps, sample... Agent: Intel/blakely

20080160604 - Apparatus for producing a stable oxidizing biocide: The invention relates to an apparatus for the production of oxidizing biocides. The apparatus can be used as a remote production system where the product is stored use or it can be an in situ production system where the product can be in fluid connection with the system being treated.... Agent: Nalco Company

20080160605 - Filter contamination control device: A biological specimen filter, for use in a biological specimen collection and transfer system having a vacuum source, comprises a tubular body having an exterior surface, an interior chamber, a first end configured to couple to the vacuum source, and a second end having an opening in communication with the... Agent: Vista Ip Law Group LLP

20080160607 - Dna construct encoding ce7-specific chimeric t cell receptor: Genetically engineered, CE7-specific redirected immune cells expressing a cell surface protein having an extracellular domain comprising a receptor which is specific for CE7, an intracellular signaling domain, and a transmembrane domain, and methods of use for such cells for cellular immunotherapy of CE7+ neuroblastoma are disclosed. In one embodiment, the... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080160606 - Genetically engineered p30 antigen, improved antigen cocktail, and uses thereof: The present invention relates to a genetically engineered P30 antigen and a combination or mixture of antigens (e.g., the genetically engineered P30 antigen and P35) that may be used in the detection of IgM and/or IgG antibodies to Toxoplasma gondii. Furthermore, the present invention also relates to methods of using... Agent: Paul D. Yasger Abbott Laboratories

20080160608 - Method for the separation and sorting of different biological objects utilizing differences in their viscoelastic properties: A method for separating a multitude of biological objects by the type of the object. The method utilizes the differences in the viscoelastic properties for the different types of objects. As an example but not limited to: the method can be applied to most tumor cells that might be present... Agent: Foley And Lardner LLP Suite 500

20080160609 - Overexpression of aminoacyl-trna synthetases for efficient production of engineered proteins containing amino acid analogues: Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallylglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine.... Agent: Seed Intellectual Property Law Group Pllc

20080160610 - Methods for stem cell expansion and differentiation: The present invention provides methods, culture media, and apparatus to produce useful amounts of specific cell populations ex vivo by the modulation of Opn and/or an active Opn fragment. The present invention provides ex vivo expanded populations of HSC for use in transplantation therapy and in clinical and research activities,... Agent: Bozicevic, Field & Francis LLP

20080160611 - Non-isopyknic cell purification using percoll: A method of “non-isopyknic” cell isolation and purification has the steps of adding a sample of blood to a defined volume to a corresponding ratio volume of EDTA solution to produce a volume of anti-coagulated blood; taking a predetermined volume of the anti-coagulated blood and placing it in a first... Agent: David L. King, Sr.

20080160613 - Nonhuman model animal lacking the ability to control lymphocyte migration: The present invention provides a animal model useful in identifying a molecule controlling in a lymphocyte-specific manner migration and thus elucidating immune-related diseases and pathogenic conditions such as allergy, autoimmune diseases, GvH and graft rejections at a molecular level, or in developing a novel therapy. A nonhuman animal model such... Agent: Frommer Lawrence & Haug

20080160612 - Treatment of infected tissues with hypochlorous acid: Super-oxidized water based on hypochlorous acid, such as is obtained by the electrochemical treatment of a saline solution, may be used in the treatment of leg ulcers or other open wounds. Preferably, the pH of the super-oxidized water is in a range of 4 to 7, and the water has... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080160614 - Stable differentiation of adult stem cells: A method of differentiating adult stem cells, such as those derived from a teratocarcinoma cell line, the Ntera2/D1 clone (NT2). The developed cells exhibit a stable neurotransmitter phenotype without the required use of growth factors or retinoic acid in differentiation process, which may be difficult to completely remove during commercial... Agent: Smith Hopen, Pa

20080160615 - Flavonoids-rich tissues from neomarica gracilis and methods for culturing the same: The present invention provides an in vitro flavonoid-rich rhizome tissue of Neomarica gracilis, which is obtained from a tissue culture preparation of an N. gracilis tissue capable of proliferating, such as a root, a leaf, a basal portion of a leaf, and/or a rhizome. The in vitro flavonoid-rich rhizome tissue... Agent: Andrews Kurth LLP

20080160616 - Nucleotide sequence encoding the enzyme i-scei and the uses thereof: An isolated DNA encoding the enzyme I-SceI is provided. The DNA sequence can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080160617 - Agent for inducing embryonic stem cell to ectodermal cell, method for obtaining the same, and use of the same: A method for obtaining a solution having activity to induce differentiation of an embryonic stem cell into an ectodermal cell or ectoderm-derived cell, which comprises culturing a stromal cell in a culture comprising a polyanionic compound and recovering the culture; a solution having activity to induce differentiation of an embryonic... Agent: Fitzpatrick Cella Harper & Scinto