Chemistry: molecular biology and microbiology inventions 06/08

20080153077 - Substrates for immobilizing cells and tissues and methods of use thereof: Described herein are substrates for immobilizing cells and tissues and methods of use thereof.... Agent: Corning Incorporated

20080153078 - System for isolating biomolecules from a sample: The present invention provides an automated system for purification of a substance of interest. The system generally comprises an instrument for moving fluids through the system, a reagent pack for storing fluids, and a purification cartridge. The cartridge comprises two filtration units for binding substances based on different physical properties.... Agent: Latimer, Mayberry & Matthews Ip Law, LLP

20080153080 - Closed photobioreactor system for continued daily in situ production, separation, collection, and removal of ethanol from genetically enhanced photosynthetic organisms: The invention provides a device for growing genetically enhanced aquatic photoautotrophic organisms in a stable culture, causing said organisms to produce ethanol, and then separating, collecting, and removing the ethanol in situ.... Agent: Greenlee Winner And Sullivan P C

20080153079 - Seafood spoilage indicator: An enzyme based nondestructive sensor for the qualitative detection of spoilage in seafood is provided wherein the sensor does not alter the physical composition of the seafood specimen. The sensor comprises a sampling matrix, at least three or more enzymes in contact with the sampling matrix, and at least one... Agent: Buchanan Ingersoll & Rooney Pc

20080153081 - Human papilloma virus detection with dna microarray: A method is provided of detecting the presence of HPV comprising the following steps: a. amplification and labelling part of the E1 HPV gene, in particular its 3′ end; b. hydrizing the labelled fragment to a solid support containing microarrays with various HPV specific capture probes; c. removing uncaptured labeled... Agent: Kalow & Springut LLP

20080153082 - Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes: wherein n ranges from 1 to 200; L represents a moiety comprising a functional group for attaching the polyanion polymer to the nanoparticle surface; Z represents a bridging group, and X represents Q, X′ or -Q-X′, wherein Q represents a functional group for attaching a recognition probe to the polyanion... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080153083 - Settings for recombinant adenoviral-based vaccines: The present invention provides new uses of recombinant adenoviral vectors in vaccination regimens, such as prime/boost set-ups and subsequent vaccinations and applications for gene therapy. Moreover, the invention provides new assays to determine the best regimen for applying the most suitable recombinant viral vector in a vaccination or gene therapy... Agent: Trask Britt

20080153100 - Articles having localized molecules disposed thereon and methods of producing same: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected... Agent: Morgan, Lewis & Bockius LLP (sf)

20080153089 - Blocked enzyme-probe complex: t

20080153096 - Cartridge for conducting diagnostic assays: Provided is a cartridge for use in conducting diagnostic assays. The cartridge is configured to maintain sample fluids in a sealed manner and may be used to conduct one or more assays from a single patient sample within a single cartridge. Assays that may be conducted with the cartridge of... Agent: Sheppard, Mullin, Richter & Hampton LLP

20080153095 - Charge switch nucleotides: The present invention provides compounds, methods and systems for sequencing nucleic acid using single molecule detection. Using labeled NPs that exhibit charge-switching behavior, single-molecule DNA sequencing in a microchannel sorting system is realized. In operation, sequencing products are detected enabling real-time sequencing as successive detectable moieties flow through a detection... Agent: Townsend And Townsend And Crew, LLP

20080153090 - Circulating mrna as diagnostic markers: Methods and kits are provided for diagnosing, monitoring, or predicting the conditions of pre-eclaimpsia, fetal chromosomal aneuploidy, and pre-term labor in a pregnant woman, as well as for detecting pregnancy in a woman, by quantitatively measuring in the maternal blood the amount of one or more mRNA species encoding human... Agent: Townsend And Townsend And Crew, LLP

20080153101 - Compositions and methods for identifying agents that alter expression of survivin: Provided are compositions and methods for identifying agents that can modulate expression of the human survivin gene. The compositions include eukaryotic cells that contain a human survivin promoter sequence operably linked to a reporter gene. The method comprises determining whether a test agent can modulate transcription from a human survivin... Agent: Hodgson Russ LLP The Guaranty Building

20080153088 - Cystic fibrosis transmembrane conductance regulator gene mutations: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further... Agent: Foley & Lardner LLP

20080153103 - Label-free optical sensing and characterization of biomolecules by d8 or d10 metal complexes: The present invention provides a composition for detecting and/or characterizing a multiple-charged biomolecule comprising a charged d8 or d10 metal complex, wherein the metal complex electrostatically binds to the multiple-charged biomolecule to induce aggregation and self-assembly of the metal complex through metal-metal interactions, π . . . π interactions, or... Agent: Cooper & Dunham, LLP

20080153092 - Markers of renal transplant rejection and renal damage: The present invention relates to methods of detecting renal transplant rejection and other forms of renal damage. Protein markers or renal damage are provided, along with assays for detecting said markers. Also provided are methods for identifying markers of renal damage.... Agent: Dann, Dorfman, Herrell & Skillman

20080153087 - Method and apparatus for orienting aspherical cells: A method for the orientation of a sperm cell to determine cell differences due to size, mass, or density is used to distinguish X chromosome-bearing sperm cells from Y chromosome-bearing sperm cells and therefore have use in in-vitro and in-vivo fertilization procedures. The orientation of individual sperm cells is determined... Agent: Brooks Kushman P.c.

20080153091 - Method and device for detecting the presence of target nucleic acids in a sample, and microfluidic device for use in such methods: A method comprising loading sample into at least two sample chambers, subjecting the sample portions in each sample chamber to at least a first amplification step, and determining whether each sample portion contains at least one molecule of a target nucleic acid. If a sample portion contains at least a... Agent: Burr & Brown

20080153093 - Method for determining risk of adverse effect of irinotecan and kit for it: A method for determining the risk of adverse effects of irinotecan (CPT-11), a synthetic anticancer drug, by detecting polymorphisms in the TATA box within the promoter region of the UDP-glucuronosyl transferase gene. A kit for detecting the adverse effects of irinotecan containing at least one pair of nucleic acid probes.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080153086 - Method for rapid identification of alternative splicing: Alternatively spliced RNA, along with their normally-spliced counterparts, can be rapidly identified by hybridizing cDNA from normal tissue to cDNA from an abnormal or test tissue. The two cDNA populations are separately tagged prior to hybridization, which allows isolation of double-stranded cDNA containing both normal and alternatively spliced molecules. Within... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20080153097 - Methods and kits for detecting jak2 nucleic acid: Disclosed are methods, kits, and components for detecting JAK2 nucleic acids in a sample. In one aspect, the methods may be used to detect mutant JAK2 nucleic acid in a mixture of mutant JAK2 nucleic acid and wild-type JAK2 nucleic acid. The methods utilize primers and reporter molecules comprising non-natural... Agent: Foley & Lardner LLP

20080153098 - Methods for diagnosing and treating breast cancer based on a her/er ratio: Provided are improved, quantitative methods for determining whether a subject is likely to respond to a breast cancer therapy, methods for selecting breast cancer therapies and methods for diagnosis and prognosis of breast cancer in subjects.... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20080153084 - Obesity markers and uses thereof: The present invention relates to a method for identification of a nucleotide substitution in the gene encoding for the neuromedin- or quantifying its levels of mRNA, to allow the determination of the susceptibility or predisposition of a patient to obesity, or to disinhibition or susceptibility to hunger. Determination of the... Agent: Birch Stewart Kolasch & Birch

20080153085 - Optical detection of analytes by use of semiconductor nanoparticles: The present invention provides an optical method and device for the determination of an analyte in an assayed sample. The method and device of the invention are based on the use of semiconductor nanoparticles that carry a recognition agent. The detection is based on fluorescence resonance energy transfer (FRET) between... Agent: Nath & Associates

20080153099 - Quantitation of human genomic dna: Methods are provided for determining, in a single polymerase chain reaction (PCR) reaction, the quantity, quality, and gender of origin of DNA in a sample, and whether or not the sample contains PCR amplification inhibitors. The methods involve carrying out a single PCR multiplex reaction utilizing primer sets specific for... Agent: Fellers Snider Blankenship Bailey & Tippens

20080153094 - Reduction of nonspecific binding in nucleic acid assays and nucleic acid synthesis reactions: The present invention relates to at least two methods: (i) methods of reducing noise and increasing efficiency in nucleic acid assays; and (ii) methods of increasing efficiency and accuracy of nucleic acid synthesis. By increasing efficiency in assays, it is meant that the reaction time to achieve a given signal... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080153102 - Rooted plant assay system: Disclosed herein are rooted plant assay systems, methods of making rooted plant assay systems, and methods of using rooted plant assay systems for high throughput screening of test polynucleotides for their ability to effect phenotypic traits having agricultural value.... Agent: Basf Corporation

20080153104 - Gene overexpressed in cancer: Disclosed are a protein encoded by a gene having a nucleotide sequence represented by any of SEQ ID NOs: 1 to 65 or a fragment thereof, an antibody recognizing the protein or antigen-binding fragment thereof, and a polynucleotide having a sequence comprising at least 12 consecutive nucleotides of a nucleotide... Agent: Davidson, Davidson & Kappel

20080153109 - Immunoassay: A method for detection and/or quantification of cardiac troponin I (cTnI) in a sample derived from an individual's blood, the method being based on a sandwich immunoassay employing at least two capture antibodies and at least one tracer antibody, in which a first capture antibody is directed to the N-terminal... Agent: James C. Lydon

20080153106 - Me-5, me-2, and epp2: human protein antigens reactive with autoantibodies present in the serum of women suffering from endometriosis: Three human endometrial antigens, ME-5, ME-2 and EPP2, and combination thereof have been discovered that are the targets of antibodies present in the serum of women suffering from endometriosis. These protein products and the human antibodies reactive with them are used as tools for diagnostic assays that monitor patients with... Agent: Siemens Corporation Intellectual Property Department

20080153107 - Methods and means for modulating pge synthase activity: Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.... Agent: Dann, Dorfman, Herrell & Skillman

20080153105 - Optical sensor and methods for measuring molecular binding interactions: Methods and devices for the measurement of molecular binding interactions. Preferred embodiments provide real-time measurements of kinetic binding and disassociation of molecules including binding and disassociation of protein molecules with other protein molecules and with other molecules. In preferred embodiments ligands are immobilized within pores of a porous silicon interaction... Agent: John R. Ross Trex Enterprises

20080153108 - Use of cross-protection to identify novel vaccine candidates for infectious agents: This invention discloses methods for identifying Francisella tularensis vaccine candidates. It enables identification of novel vaccine candidates and quality assurance for vaccine batches, assessment of protection in vaccinates and identification of the infecting agent in vaccinates. Mice were first vaccinated with Brucella abortus O-polysaccharide (OPS) vaccine. These animals were then... Agent: Nixon & Vanderhye, Pc

20080153110 - Combination rapid detection cartridges for biological and environmental agents, methods of production and uses thereof: Hand-held test cartridges are described herein that comprise at least one assay, where each assay can simultaneously test for at least two different types of biological agents, environmental agents or combinations thereof. Methods of measuring biological and environmental agents are described herein that include: providing at least one multicomponent hand-held... Agent: Buchalter Nemer

20080153112 - Antigens targeted by prevalent pathogennic t cells in type 1 diabetes and uses thereof: The present invention is based on the identification of a predominant ligand of CD8+ T cells that are responsible eq for type 1 diabetes. That ligand is islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP). Several CD8+ T cell-binding peptides from IGRP are identified, including the peptide comprising amino acids 206-214 of... Agent: Amster, Rothstein & Ebenstein LLP

20080153113 - Tumour markers: A method of determining the immune response of a mammal to circulating tumour marker proteins is described in which a sample of bodily fluid, for example plasma or serum, is contacted with a panel of two or more distinct tumour marker antigen. The presence of complexes between the tumour marker... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20080153114 - Methods, compositions, and kits for the detection of bacteria in a sample: The present invention includes compositions, kits, and methods useful for the detection of bacteria. These agents and methods are primarily directed to a method of detecting the presence of bacteria in a sample, involving incubating the sample with an agent that binds to bacteria, such as, e.g., an agent specific... Agent: Seed Intellectual Property Law Group Pllc

20080153111 - Method and composition for detecting protein-protein and protein-nucleic acid interactions: The present invention provides methods and compositions for detecting protein-protein and/or protein-nucleic acid interactions in cells.... Agent: Banner & Witcoff, Ltd.

20080153115 - Compositions and methods for diagnosing patients with acute atherosclerotic syndrome: The present invention is in the field of autoimmunity. More specifically, the present invention relates to the detection of autoantibodies to domain 4 of beta 2-glycoprotein I (β2-GPI) as an indicator for atherosclerosis.... Agent: Gordon & Rees LLP

20080153116 - Diagnostic blood test using adsorption on filter paper: A diagnostic test and method is provided comprising mixing blood or another biological fluid sample with a test compound and spotting the blood on filter paper for subsequent analysis of the effect of the test compound on the blood. The biological fluid can be a cerebrospinal fluid, a peritoneal fluid,... Agent: Howson And Howson

20080153117 - Prion test: The invention is related to diagnostic methods for detecting transmissible spongiform encephalopathies (TSEs) such as BSE and scrapie and related disease in humans. The invention provides use of guanidine thiocyanate (gdnSCN), or a functional equivalent thereof, for treating at least one sample derived from a mammal, including humans, for reducing... Agent: Trask Britt

20080153118 - Method and device for determining the glucose concentration in tissue liquid: The invention relates to a method and a device for determining the glucose concentration in tissue fluid whereby test values for glucose and for an endogenous reference substance are detected in a sample liquid obtained by microdialysis, microperfusion or ultrafiltration, and the glucose value is corrected in accordance with the... Agent: Baker & Daniels LLP / Roche

20080153119 - Detecting the presence of pyruvate kinase isoenzyme in feces: In order to selectively, qualitatively or/and quantitatively detect the pyruvate kinase isoenzyme of the tumor M2-PK type (tumor M2-PK) which serves as a tumor marker in human and animal feces to detect a malignant process in the gastrointestinal tract, tumor M2-PK is detected in a stool specimen by an immunoassay... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080153120 - Salt taste receptor and its use in an assay for salt taste: A functional human salt taste receptor and a cell based assay that simulates human salt taste stimulation is disclosed. A method for the identification of enhancers or modulators of salt taste and food products that contain them is also disclosed. The method for the production of food products with desirable... Agent: Bell, Boyd & Lloyd LLP

20080153121 - Chemical sensor enhanced by direct coupling of redox enzyme to conductive surface: The invention provides a method, apparatus and system for detecting electrochemical oxidoreduction activity mediated by a redox enzyme at a site remote from the enzyme. In one embodiment, the method comprises immobilizing the redox enzyme on a first region of a conductive surface and contacting a substrate capable of producing... Agent: Karen S. Canady Canady & Lortz LLP

20080153122 - Method and system for enhancing self-treatment of onychomycosis: Methods, systems, and devices for medical therapy compliance for the treatment of onychomycosis with a topically applied antifungal agent.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20080153123 - Method for detection of camp and cgmp: The present invention relates to an in vitro method for detecting cAMP or cGMP comprising a) contacting a mixture with a complex of a tracer and a dequencher, wherein the tracer is a fluorophore covalently linked to a cAMP quencher, and b) measuring the change in fluorescence. Furthermore, the present... Agent: Hoffmann-la Roche Inc. Patent Law Department

20080153124 - Methods for improving the function of heterlogous g protein-coupled receptors: This invention relates to mutant G protein-coupled receptors with improved G-protein coupling and receptor response, yeast cells expressing such receptors, vectors useful for making such cells, and methods of making and using same.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080153125 - Rapid detection of microorganisms in fluids: A system for the rapid detection of microbial contamination in a fluid sample such as water, involving the use of a filter material having a surface adapted to receive the sample in order to retain substantially all microbes from the sample on the filter surface under conditions that minimize the... Agent: Intellectual Property Group Fredrikson & Byron, P.a.

20080153126 - Mutant aox1 promoters: A mutant Pichia pastoris alcohol oxidase 1 (AOX1) promoter of the wild type Pichia pastoris AOX1 promoter (SEQ ID No. 1) comprising at least one mutation selected from the group consisting of: a) a transcription factor binding site (TFBS), b) nucleotides 170 to 235 (−784 to −719), nucleotides 170 to... Agent: Chalker Flores, LLP

20080153127 - High quality, continuous throughput, tissue processing: A process and apparatus for rapid, continuous flow histological processing of tissues is disclosed. The steps of fixation, dehydration, clearing and impregnation are performed in less than one hour; this allows a pathologist to evaluate samples shortly after receipt, perhaps while the patient is still in the operating room. Rapid... Agent: Nixon & Vanderhye, Pc

20080153128 - Cell-free protein synthesis: The present invention relates to a method for synthesizing a protein in a cell-free synthesis system, which comprises the steps of: (a) amplifying a DNA molecule encoding the protein to prepare linear DNA molecules with a stem and loop sequence at their terminus, wherein the stem and loop sequence comprises... Agent: Clark & Elbing LLP

20080153129 - Method for universal enzymatic production of bioactive peptides: The invention provides methods for making peptides from a polypeptide containing at least one copy of the peptide using clostripain to excise the peptide from the polypeptide. The methods enable the use of a single, highly efficient enzymatic cleavage to produce any desired peptide sequence.... Agent: Schwegman, Lundberg & Woessner, P.a.

20080153132 - Genetic recombinant ecarin and process for preparing the same: A recombinant ecarin protein that specifically activates prothrombin, said protein being efficiently prepared by the genetic engineering technique comprising the steps: (1) culturing a transformant microorganism or animal cell transformed with an expression vector in which a gene encoding ecarin is incorporated to the downstream of a promoter so as... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080153131 - Soluble t cell receptors: The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all or part of a TCR α chain, except the transmembrane domain thereof, and (ii) all or part of a TCR β chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain... Agent: Banner & Witcoff, Ltd.

20080153130 - Ubp1 protease mutant and its coding sequence, their applications and heterogonous protein expression system: Invention relates to novel and improved UBP1 protease mutants with a substitution at position (754), a deletion of amino-acids at position (1-54) and at least a portion of the amino-acids found at position (55-98) and their coding sequence as well as their applications and heterogonous protein expression system comprising thereof.... Agent: Gary J Gershik Cooper & Dunham

20080153133 - Metabolically engineered escherichia coli for enhanced production of sialic acid: A metabolically engineered E. coli strain which produces sialic acid and a method of making said strain. In the engineered E. coli cells, the nanT (sialic acid transporter) and nanA (sialic acid adolase) genes are inactivated, and the neuC and neuB genes of sialic acid biosynthesis in Neisseria meningitidis group... Agent: Bond, Schoeneck & King, Pllc

20080153135 - Methods and apparatus for conducting amplification reactions on high density hydrophilic patterned microplates: A microplate for use in performing PCR on a target. The microplate having a substrate with a hydrophobic surface and a plurality of hydrophilic reaction spots on the hydrophobic surface of the substrate. Each of the reaction spots having a capacity to retain less than 5 nanoliters of an aqueous... Agent: Harness, Dickey & Pierce, P.L.C

20080153134 - Methods and apparatus for generating hydrophilic patterning of high density microplates using an amphiphilic polymer: A microplate having a substrate with a hydrophobic surface and a plurality of hydrophilic reaction spots on the hydrophobic surface. Each of the plurality of reaction spots having an amphiphilic polymer and a polynucleotide conjugated to the amphiphilic polymer.... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080153136 - Acid-stable alpha amylases having granular starch hydrolyzing activity and enzyme compositions: The present invention relates to an acid-stable alpha amylase (asAA) derived from a strain of Aspergillus kawachi, which has granular starch hydrolyzing (GSH) activity, the heterologous expression of the asAA having GSH activity in filamentous fungal host cells and enzyme compositions including the same which optionally include glucoamylase.... Agent: Lynn Marcus-wyner Genecor International, Inc.

20080153137 - Stereoinversion of amino acids: A process is described to prepare a single enantiomer of an amino acid from its opposite enantiomer or from a racemic mixture, using an oxidase biocatalyst and a supported metal catalyst in separate, sequential reactions in water. The process can be operated in batch or continuous mode.... Agent: Rosenbaum & Associates, P.c.

20080153138 - Method for producing l-amino acids using escherichia bacteria: A method for producing an L-amino acid, such as L-phenylalanine and L-threonine, is provided using an Escherichia bacterium, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing the activity of the protein encoded by the yedA gene. A further method is provided for producing a lower alkyl... Agent: Cermak & Kenealy LLP Acs Llc

20080153139 - Method for the fermentative production of l-valine and suitable microorganism: The invention relates to a method for producing L-valine and to a suitable microorganism. The inventive method is characterized by preferably enhancing the transaminase C activity of a coryneform bacterium, especially Corynebacteriuim glutamicum. The organisms so modified have a yield in L-valine which is 35.8% higher than that of non-modified... Agent: K.f. Ross P.c.

20080153140 - Method for the enantioselective enzymatic reduction of keto compounds: The present invention relates to a process for the enantioselective enzymatic reduction of keto compounds, in particular of 4-halo-3-oxobutyric acid esters, to the corresponding R-alcohols or S-4-halo-3-hydroxybutyric acid esters, respectively, using an R-specific oxidoreductase in the presence of a cofactor.... Agent: Birch Stewart Kolasch & Birch

20080153143 - Compositions which can be used as biofuel: A composition comprising alkyl esters, with a C1-C8 alkyl group, and partial glycerides, with a free glycerol content of, at most, 2%, by weight, based on the weight of the composition, derived in an enzymatically-catalyzed reaction from saturated or unsaturated, straight or branched C8-C22 fatty acids of vegetable oils, and... Agent: Cognis Corporation Patent Department

20080153141 - Delta - 9 desaturase and its use in making polyunsaturated fatty acids: The present invention relates to a Δ9 desaturase, which has the ability to convert palmitic acid [16:0] or stearic acid [18:0] into palmitoleic acid [16:1] or oleic acid [18:1], respectively. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ9 desaturase along with a method of making long... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080153142 - Process for producing triglycerides constituted by three polyunsaturated fatty acid residues of one type and utilization thereof: The invention provides a process, for producing fats or oils in which the rate of triglycerides constituted by the same polyunsaturated fatty acids linking to the three hydroxyl groups of glycerol is 20% or more by weight for the total triglycerides, which comprises culturing a microorganism capable of producing said... Agent: Drinker Biddle & Reath (dc)

20080153144 - Method for converting herbaceous plant fibers into fuel alcohol: This disclosure teaches a method of converting herbaceous plant fibers into fuel alcohol comprising the following steps: The pre-treatment stage consists of grinding; using ultrasonic waves; adding the liquids mixed with alcohol, liquid ammonia, and water; adding NaOH; and then stirring and cooking. The second stage involves the recovery of... Agent: Matthias Scholl

20080153145 - Process for conversion of dairy cow waste to biofuel products: A process and system for converting animal waste to useful biofuel products, and more particularly a process and system for converting excrement from lactating dairy cattle to a combination of ethanol, methane, carbon dioxide and fertilizer is presented. The system uses a continuous process to place the animal waste into... Agent: Kauth , Pomeroy , Peck & Bailey ,llp

20080153146 - Apparatus and method for electrically contacting biological cells suspended in a liquid: An apparatus for electrically contacting biological cells suspended in a liquid has a substrate having at least one opening and an electrode for electrically contacting a cell immobilized above the opening. A contact unit with a contact tip is arranged below said opening. A top end of the contact tip... Agent: Knobbe Martens Olson & Bear LLP

20080153147 - Compositions, organisms and methodologies employing a novel human kinase: This invention provides compositions, organisms and methodologies employing a novel human protein kinase, MCRK1. The novel human kinase has sequence homology to rat myotonic dystrophy kinase-related Cdc42 binding kinase (MRCK) alpha. The gene encoding the novel kinase is localized in locus 11q13 of human chromosome 11. The novel protein kinase... Agent: Choate, Hall & Stewart LLP/wyeth

20080153148 - Increasing bioavailability of carotenoids: A method of increasing a fraction of free carotenoids in a source of carotenoids in which at least some of the carotenoids are fatty acid esterified carotenoids is disclosed. The method is effected by contacting the source of carotenoids with an effective amount of an esterase under conditions effective in... Agent: Martin D. Moynihan Prtsi, Inc.

20080153149 - Purification of thin stillage from dry-grind corn milling with fungi: The present invention is directed to an improved method of processing thin stillage from ethanol production and/or other industrial processes to produce high value fungal biomass that can be recovered by simple means. The effluent is sanitized and recycled using a novel disinfection technique. This innovative approach generates revenue from... Agent: Mckee, Voorhees & Sease, P.L.C

20080153150 - Delivery of molecules to a lipid bilayer: A method of delivering a molecule, such as a membrane protein, to a lipid bilayer uses a probe capable of holding the molecule on a carrier surface thereof. The molecule is deposited on the carrier surface and the probe is moved to engage the carrier surface against the lipid bilayer.... Agent: Nixon & Vanderhye, Pc

20080153152 - Microfluidic chip: A microfluidic chip, includes: a first port for inputting: a sample liquid; and a first liquid; a second port for inputting a second liquid; a third port for supplying air pressure; a first channel (A) for mixing the sample liquid and the first liquid to generate a first mixed liquid;... Agent: Birch Stewart Kolasch & Birch

20080153151 - System and apparatus for use in detecting microorganisms: A system and an apparatus for use in detecting a target microorganism or agent is disclosed which involves a solid support carrying a binding partner specific for the particular microorganism or agent and the solid support being characterised in that it defines means for protecting the binding partner from being... Agent: Nixon & Vanderhye, Pc

20080153153 - Microorganism testing device: A measurement chip 10 includes: a specimen container 151; a reaction container 170 for mixing a specimen and a dyeing reagent into a liquid mixture; a bacteria detection portion 18 being irradiated with excitation light; a detection liquid waste container 163 into which liquid mixture which has passed the bacteria... Agent: Antonelli, Terry, Stout & Kraus, LLP

20080153154 - Water treatment system including foam block: The water to be treated might be river water which needs to be clarified, or might be septic tank effluent which needs to have its BOD and dissolved organics content diminished, and its ammonium oxidised. Treatment is done by passing the water through a block of soft open-cell foam. The... Agent: Anthony Asquith

20080153155 - Microchannel chip: A microchannel chip for introducing an inspected liquid, includes: a micro channel; and a reagent that is mixed with a heat soluble binder and is carried at a predetermined position in the micro channel, wherein dissolution of the reagent is promoted at the predetermined position as temperature of the inspected... Agent: Birch Stewart Kolasch & Birch

20080153156 - Expression of factor ix in gene therapy vectors: Two mechanisms are provided for improving the expression of Factor IX in gene therapy vectors. The first is the use of a specific Factor IX polynucleotide coding sequence designed for optimal expression. The second is the use of transcriptional regulatory regions minimized in size so that they can be used... Agent: St. Jude Children's Research Hospital Office Of Technology Licensing

20080153158 - Method and apparatus for tissue processing: A method of melting material (1), for use in tissue processing, includes placing the material in solid form (1) into a bath (16, 18, 20), and applying heat. The material (1) has a total volume that substantially equates to a predetermined fill volume of the bath (16, 18, 20), sufficient... Agent: Sughrue Mion, Pllc

20080153157 - Method of obtaining viable small tissue particles and use for tissue repair: The invention provides a composition including isolated small living tissue particles, a method of making the tissue particles, and a method of using the composition to ameliorate a tissue defect. The tissue particles are composed of cells and their associated extracellular molecules and are sized, in certain embodiments, to be... Agent: Wood, Herron & Evans, LLP (zimmer)

20080153159 - Therapeutic and diagnostic agents: The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides molecules having structural features characteristic of immunoregulatory signalling (IRS) molecules and which are expressed by cells of haematopoietic lineages such as, in particular, leukocytes. The molecules of the present invention find broad application inter... Agent: Knobbe Martens Olson & Bear LLP

20080153160 - Human malignant cystosarcoma phyllodes derived mouse cell line and its applications: A new mouse cell line, MCP-5, derived from human malignant cystosarcoma phyllodes was established. This invention provides methods for establishing MCP-5. MCP-5 may serve as both in vitro and in vivo models for studying pathogenesis and experimental therapy of human malignant cystosarcoma.... Agent: Robert D. Katz Cooper & Dunham LLP

20080153162 - Double-stranded and single-stranded rna molecules with 5' triphosphates and their use for inducing interferon: Double-stranded and single-stranded RNA molecules, and their use in methods for inducing interferon are provided. The interferon induction provides anti-viral and other medically useful effects, such as anti-cancer effects. Also provided are methods for reducing or inhibiting interferon induction exhibited by such molecules, particularly siRNA and shRNA molecules produced in... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080153161 - Genetically encoded photosensitizers and methods for using same: The present invention provides genetically encoded photosensitizers developed based on fluorescent or chromo-proteins. Specific genetically encoded photosensitizers and nucleic acid molecules encoding the same are provided. Also of interest are host cells, stable cell lines and transgenic organisms comprising the above-referenced nucleic acid molecules and proteins. The subject protein and... Agent: Patterson & Sheridan, L.l.p.

20080153163 - Compositions and methods for the expansion and differentiation of stem cells: The instant invention provides methods and compositions for the expansion and differentiation of stem cells.... Agent: Edwards Angell Palmer & Dodge LLP Client: Jhu

20080153164 - Culture medium named mv06 for both endothelial and myocardiac cells: A culture medium named MV06 enabling growth in vitro of both endothelial progenitor and myocardiac progenitor cells, composed of: Iscove's Modified Dubellco's Medium, Fetal calf serum, Horse serum, L-Glutamin (200 mM (100×)) Penicillin (10000 u/mL)/Streptomycin (1000 μg/mL), Hu-R Bone Morphogenetic Protein 2 (BMP-2), Hu-R Fibroblast Growth Factor 2 (FGF2), and... Agent: Davis Bujold & Daniels, P.l.l.c.

20080153165 - Method for the production of biomass from plant differentiated tissue: The present invention provideS a method and a culture medium for the production of food biomass by directly culturing seed kernel tissue, or seed cotyledonary differentiated tissue. The culture medium of the present invention contains at least DKW culture medium, Vitamin MS culture medium with an enriched concentration of thiamine,... Agent: John J. Martinez Md. Jd.

20080153166 - Stable lipid-comprising drug delivery complexes and methods for their production: Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention... Agent: Morrison & Foerster LLP

20080153167 - In vivo amplification of neural progenitor cells: The invention is directed to methods for in vivo amplification of neural progenitor cells using the proliferative environment of glial neoplasms in adult brain. The progenitor cells have the capacity to proliferate and differentiate into mature brain cells which can be used for cell replacement therapies. The invention also provides... Agent: Wilmerhale/columbia University

20080145833 - Organ transportation device: An organ transportation device includes a fluid-tight organ container and structure within the organ container for engaging an organ within the organ container. A base assembly is provided, and structure for rotating the organ engaging structure and the organ relative to the base assembly. The base assembly can have a... Agent: Akerman Senterfitt

20080145834 - Freeze-dried platelets as a diagnostic agent: The present invention provides freeze-dried platelets and compositions comprising freeze-dried platelets for use as a diagnostic and calibration reagent for blood coagulation function. The invention also provides methods of diagnosing or monitoring blood coagulation function, including diagnosing or monitoring blood coagulation diseases and disorders. Kits for performing the methods of... Agent: Latimer, Mayberry & Matthews Ip Law, LLP

20080145836 - Compositions and methods for detection of lysosomal storage disease: The present invention provides compositions for performing assays of enzyme activity associated with lysosomal storage diseases. The invention further provides methods for determining enzyme activity, and methods for the screening for lysosomal storage disease in an individual.... Agent: Edwards Angell Palmer & Dodge LLP

20080145835 - Multistep reaction lateral flow capillary device: Disclosed is a lateral flow capillary device and uses thereof comprising a unipath bibulous capillary flow matrix and at least two reservoirs each in fluid communication with the capillary flow matrix wherein a reservoir contacts the capillary flow matrix through a passage having a rim pressing the matrix. The pressure... Agent: Martin D. Moynihan Prtsi

20080145838 - Method of measuring interaction between biomaterial and sugar chain, method of evaluating biomaterial in sugar chain selectivity, method of screening biomaterial, method of patterning biomaterials, and kits for performing these methods: This invention provides a method of screening or patterning a biomaterial in terms of their specificities to sugar chains by performing real-time and comprehensive measurement of an interaction between sugar chains and the biomaterial concurrently with a very small amount of the biomaterial without labeling. It is a method of... Agent: Morrison & Foerster LLP

20080145837 - Non-elispot assay: A method of detecting the production of an analyte by cells in a sample, which method comprises: (i) providing an antibody capable of binding to said analyte and a first agent capable of enhancing detection of said analyte, wherein said antibody and said first agent are immobilised on the same... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20080145858 - Detection and identification of toxicants by measurement of gene expression profile: A screen for detecting, identifying, and characterizing chemicals as toxicants is based on the affect of the chemical on gene expression in animal cleavage stage embryos. A microarray screen for detecting and measuring the affects of chemicals on gene expression in animal cleavage stage embryos. A screen for detecting, identifying... Agent: Amy E. Rinaldo Kohn & Associates, Pllc

20080145859 - Diagnosis and treatment of cancer: s

20080145841 - Diagnostic tool for diagnosing benign versus malignant thyroid lesions: The present invention relates to the use of genes differentially expressed in benign thyroid lesions and malignant thyroid lesions for the diagnosis and staging of thyroid cancer.... Agent: Needle & Rosenberg, P.c.

20080145860 - Encapsulated cell indicator system: The invention features an encapsulated cell indicator system that includes (a) indicator cells having a signal-responsive element operably linked to a reporter gene; (b) encapsulating material; and (c) a permeable membrane. In this encapsulated cell indicator system, the indicator cells are encapsulated in the encapsulated material and the encapsulated material... Agent: Clark & Elbing LLP

20080145843 - Enzyme detection techniques: A lateral flow assay device for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The lateral flow assay device utilizes a molecular substrate to facilitate the detection of an enzyme or enzyme inhibitor via detection of the substrate and/or a product formed in an enzyme-catalyzed... Agent: Dority & Manning, P.a.

20080145846 - Hla alleles associated with adverse drug reactions and methods for detecting such: This invention relates to a method of determining the presence of certain HLA alleles, such as HLA-B*1502 or HLA-B*5801, and a kit for carrying out this method. Also disclosed is a method for assessing whether a patient is at risk for developing adverse drug reactions (e.g., Stevens-Johnson syndrome, toxic epidermal... Agent: Occhiuti Rohlicek & Tsao, LLP

20080145840 - Isothermal titration calorimetry assays: A method for identifying a modulator of a biological process or a biomolecule.... Agent: Astrazeneca R&d Boston

20080145850 - Mass labels: Provided herein are sets of mass labels. Each mass label in a set includes: 1) a mass marker moiety; 2) a mass normalisation moiety; and 3) a cleavable linker connecting the mass marker moiety to the mass normalisation moiety. Each mass marker moiety is characterized as having a mass different... Agent: Crowell & Moring LLP Intellectual Property Group

20080145856 - Method and apparatus for detecting a ligand in a fluid: In a method for detecting at least one ligand that is suspected to be contained in the fluid that is being tested, at least one marker that is suitable for binding to the ligand is placed in the fluid. At least one measured value for the diffusion rate of the... Agent: The Webb Law Firm, P.c.

20080145848 - Method and kit for detecting mycobacterium avium subsp. paratuberculosis (map) in samples of faeces, body tissues or milk: Method for the detection of Mycobacterium avium subsp. paratuberculosis (MAP) in fecal, body tissue or milk samples, in which a DNA extract is obtained from the samples, the DNA extract is processed by means of PCR in the presence of MAP-specific primers (MAP primers), and it is tested whether or... Agent: Rankin, Hill & Clark LLP

20080145845 - Method and kit for the identification and/or detection and/or quantification of large number of genes related to antibiotic resistance in (micro) organisms: The present invention is related to a method and kit (or device) for identifying and/or quantifying in an array mRNA nucleotide sequences related to resistance to antibiotic(s) being expressed in a (micro)organism present in a sample.... Agent: Knobbe Martens Olson & Bear LLP

20080145839 - Method and nucleic acids for the differentiation of astrocytoma, oligoastrocytoma and oligodenroglioma tumor cells: Chemically modified nucleic acid sequences of genomic DNA, oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA. In addition, a method for ascertaining genetic and/or epigenetic parameters of genes for the characterization, classification, differentiation, grading, staging, treatment and diagnosis of oligodendrogliomas, astrocytomas and oligoastrocytomas.... Agent: Davidson, Davidson & Kappel, Llc

20080145854 - Method for efficiently detecting double-stranded nucleic acid: This invention relates to a method for efficiently detecting double-stranded nucleic acids. More particularly, this invention relates to a method for reducing signals derived from an intercalator bound to a single-stranded nucleic acid, wherein a compound that reacts more preferentially with an intercalator bound to a single-stranded nucleic acid than... Agent: Fish & Richardson P.c.

20080145852 - Methods and compositions for detecting adenoma: Aspects of the invention relate to methods and compositions for detecting adenomas in biological samples. Aspects of the invention provide panels of genetic markers that can be used to detect adenomas in biological samples with different levels of sensitivity. Embodiments of the invention may be used to screen stool samples... Agent: Goodwin Procter LLP Patent Administrator

20080145853 - Methods and kits for detection of chromosome aneuploidy by high performance liquid chromatography with post-column fluorescence detection: Methods and kits for determining aneuploidy of selected chromosomes by multiplex polymerase chain reaction (PCR) and post-column fluorescence high performance liquid chromatography (PCF-HPLC) are provided.... Agent: Licata & Tyrrell P.c.

20080145849 - Methods for diagnosing and treating neuroendocrine cancer: The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods for preventing and treating neuroendocrine cancers are also disclosed.... Agent: Licata & Tyrrell P.c.

20080145847 - Methods for identification of sepsis-causing bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of sepsis-causing bacteria by molecular mass and base composition analysis.... Agent: Casimir Jones, S.c.

20080145844 - Methods of cdna preparation: The present invention provides an improved method for cDNA preparation. The method of the present invention comprises the following steps: (1) contacting mRNA with a cDNA synthesis primer which can anneal to RNA and a suitable enzyme which possesses reverse transcriptase activity under conditions sufficient to permit the template-dependent extension... Agent: Patterson & Sheridan, L.l.p.

20080145861 - Methods of protein production in cell lines: The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins.... Agent: Avigenics, Inc.

20080145851 - Methods, kits and assay system for detecting drug-resistant mycobacterium tuberculosis: The present invention relates to methods, kits and assay system for detecting drug-resistant Mycobacterium tuberculosis of suspected patient. The system of the present invention largely reduces the whole process of drug-resistant M. tuberculosis detection in less than 5 hours.... Agent: Bruce H. Troxell

20080145857 - Microorganism detection system: A microorganism detection system in the present invention has an analysis chip and an analyzer. Necessary reagents are stored in advance in the analysis chip. A sample is injected into the analysis chip, which is then inserted into the analyzer. The analyzer has a pressure source for supplying a gas... Agent: Antonelli, Terry, Stout & Kraus, LLP

20080145855 - Mutations in the ferroportin 1 gene associated with hereditary haemochromatosis: The present invention relates to mutations in the gene coding for ferroportin 1 associated with hereditary haemochromatosis and methods for the diagnosis of hereditary haemochromatosis based on the identification of such mutations.... Agent: Jones Day

20080145842 - Novel test method for taste abnormality: A method for testing dysgeusia, which is characterized in that it comprises amplifying at least a portion of a gene encoding a taste receptor belonging to the THTR family and a gene encoding a taste receptor belonging to the T2R family collected from a sample derived from the oral cavity;... Agent: Birch Stewart Kolasch & Birch

20080145863 - Affinity selected signature peptides for protein identification and quantification: A method for protein identification in complex mixtures that utilizes affinity selection of constituent proteolytic peptide fragments unique to a protein analyte. These “signature peptides” function as analytical surrogates. Mass spectrometric analysis of the proteolyzed mixture permits identification of a protein in a complex sample without purifying the protein or... Agent: Mueting, Raasch & Gebhardt, P.a.

20080145865 - Assays for rab5 activity: Methods of determining intracellular levels of Rab5 activity are disclosed, as well as fusion proteins utilized in such methods and recombinant constructs encoding such fusion proteins. The fusion protein contains a Rab5-binding domain that specifically binds to an activated form of Rab5-GTP, and a tag conjugated thereto, wherein the tag... Agent: Dunlap Codding & Rogers, P.c.

20080145864 - Diagnosis method of alcoholic or non-alcoholic steato-hepatitis using biochemical markers: The present invention is drawn to a new diagnosis method for detecting the extent of alcoholic or non-alcoholic steato-hepatitis in a patient, in particular in a patient suffering from a disease involving alcoholic or non-alcoholic steato-hepatitis or who already had a positive diagnosis test of liver fibrosis and/or presence of... Agent: Foley And Lardner LLP Suite 500

20080145862 - Molecular microarrays and helical peptides: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a... Agent: Intel/blakely

20080145866 - Modified human thymic stromal lymphopoietin: Modified, furin resistant human TSLP polypeptides and polynucleotides encoding the modified human TSLP polypeptides are provided. Pharmaceutical compositions, B and T cell activation agents, assays and methods of use are also described.... Agent: Immunex Corporation Law Department

20080145872 - Expression of hla proteins on non human cells: The present invention is directed to a composition that includes a functionally active, individual HLA trimolecular complex expressed on the surface of an immortalized, non-human cell line. Methods of obtaining high expression of the transferred HLA molecule, as well as assays that utilize such recombinant cell line as a platform,... Agent: Dunlap Codding & Rogers, P.c.

20080145870 - Marker for neuromyelitis optica: The present invention provides for methods and materials for diagnosing and treating neuromyelitis optica (NMO).... Agent: Fish & Richardson P.c.

20080145871 - Method for determining an allergic response: The present invention concerns a method for determining an allergic response by determining the extent of degranulation of human IgE sensitized cells upon activation by allergens in food products.... Agent: Foley And Lardner LLP Suite 500

20080145873 - Proteomic interaction and genomic action determinations in the presence of associated redox state conditions: Genomic actions and/or proteomic interactions for pathophysiological processes and for physiological processes are determined at associated redox state conditions. Protein interactions are correlated with oxygen tensions. Identification of markers for disease including epitopes is effected in the presence of simulated redox state perturbations. Screening for previously unknown receptors and activating... Agent: Eric S. Spector Jones, Tullar & Cooper, P.c.

20080145875 - Anti-tenascin monoclonal antibody immunoassays and diagnostic kits: The present invention provides immunoassays for detecting a tumor in a subject, comprising producing an antibody that specifically binds to tenascin, contacting the antibody with a biological sample suspected of containing tumor cells and determining the binding of the antibody to the biological sample. The present invention further provides methods... Agent: Darby & Darby P.c.

20080145874 - Ca ix-specific inhibitors: e

20080145876 - Poly(ethylene glycol) anti-body detection assays and kits for performing thereof: The present invention discloses an assay for determining the presence of an anti-PEG antibody in a biological sample. Embodiments according to this aspect of the present invention will generally have the steps of: (1) providing an antigen probe capable of forming an antibody-antigen complex with the anti-PEG antibody; (2) contacting... Agent: Hogan & Hartson L.l.p.

20080145867 - Genes encoding a novel type of lysophophatidylcholine acyltransferases and their use to increase triacylglycerol production and/or modify fatty acid composition: Nucleic acid molecules identified in encode lyso-phosphatidylcholine (LPC) acyltransferases. Over-expression of the LPC acyltransferases in a cell may lead to enhanced production of PUFA, or other unusual fatty acids, and/or to increased oil content in the cell.... Agent: Trask Britt

20080145877 - Ca ix-specific inhibitors: c

20080145869 - Immunoassay method: The present invention provides a method for immunoassaying an object to be analyzed including: causing to act, on a specimen or a sample including the specimen, a first protein (Y), which can specifically recognize the object to be analyzed in the specimen and is modified by a labeling substance, so... Agent: Taiyo Corporation

20080145868 - Method for diagnosing diabetes in a mammal: Provided are mammalian secreted and non-secreted diabetes mediating proteins, including protective and deleterious diabetes-mediating proteins, as well as polynucleotides encoding same, drug screening methods for identifying a test compound capable of altering the expression of a diabetes-mediating protein, and methods of preventing or ameliorating diabetes by administering a compound capable... Agent: Merchant & Gould Pc

20080145879 - Medium for the specific detection of resistant microorganisms: o

20080145878 - Method of differentiating between blood and control solutions containing a common analyte: Glucose measured in blood samples is distinguished from glucose measured in the control solutions used to test the optical instruments which make such measurements. The control solutions contain a labeling substance recognized by the optical instrument to distinguish glucose measurements made of control solutions from those made of blood samples.... Agent: Nixon Peabody LLP

20080145880 - Assays for measuring phosphate modification enzyme activity: The present invention relates to assays that can measure the activity of enzymes that catalyze phosphate modifications, such as kinases, phosphatases, cyclases and phosphodiesterases. The assays can also be used to identify and screen for substances that modulate the activity of kinases, phosphatases, cyclases and phosphodiesterases.... Agent: Roche Palo Alto Llc Patent Law Dept. M/s A2-250

20080145881 - Chromogenic medium for the detection and identification of vancomycin resistant enterococci and method therefor: A microbe-specific medium, containing specific chromogenic substrates, for the detection of vancomycin-resistant enterococci in a biological sample, whereby both the detection and identification of vancomycin-resistant enterococci at the species level is achieved utilizing one sample and one test.... Agent: David W. Highet, Vp & Chief Ip Counsel Becton, Dickinson And Company

20080145882 - Mutant hydrolase proteins with enhanced kinetics and functional expression: The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides and mutant proteins.... Agent: Schwegman, Lundberg & Woessner, P.a.

20080145883 - Biomarker in inflammatory diseases: The use of SPP2 as a target in inflammatory responses, e.g. as a biomarker, e.g. for immune disorders associated with inflammation, such as psoriasis; diagnostic kits comprising means for determining the level of SPP2 and a method for identifying agents that modulates SPP2 activity.... Agent: Novartis Institutes For Biomedical Research, Inc.

20080145884 - Sfrp and peptide motifs that interact with sfrp and methods of their use: This disclosure relates to a peptide motif and proteins containing the motif that are capable of binding to secreted Frizzled-related protein family members. Accordingly, the disclosure also includes methods of regulating the interaction of sFRP-1 with proteins containing the motif.... Agent: Klarquist Sparkman, LLP

20080145885 - Proteome standards for mass spectrometry: The invention relates generally to standard sets of proteins, polypeptides, or peptides, and methods of using the standard sets to standardize laboratories, laboratory procedures, or laboratory equipment, and to certify laboratories and laboratory technicians. In certain aspects, the invention relates to standard sets of proteins, polypeptides, or peptides, that may... Agent: Invitrogen Corporation C/o Intellevate

20080145886 - Assay for cytochrome p450 isoforms 3a4 and 3a5: A rapid and sensitive radiometric assay for assessing the activity of cytochrome P450 (CYP) 3A4/5 and the potential of an analyte to inhibit CYP3A4/5 activity or induce CYP3A4/5 expression is described. All the steps of the assay, including incubations, product separation, and radioactivity counting are preferably performed in a multiwell... Agent: Merck And Co., Inc

20080145888 - Assessment method: A method of assessing the viability of a cell comprises incubating the cell in a culture medium. The culture medium includes a plurality of amino acids and the change in concentration in the medium of at least one amino acid is determined.... Agent: Myers Bigel Sibley & Sajovec

20080145887 - Cytological filter with data storage: A read/write storage device is attached to a cytological filter used to collect cells from a container having a solution carrying a cytological specimen in the solution. Data including a flow rate of a first fluid (e.g., air) through the filter is stored in the data storage device, and may... Agent: Vista Ip Law Group LLP

20080145889 - Islet cells from human embryonic stem cells: This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High quality populations of islet cells can be produced in commercial quantities for use in research,... Agent: Geron Corporation

20080145890 - Detection of signaling molecules in a biological environment: A method of detecting and identifying bacteria, micro-organisms or plants in a liquid or gaseous medium, the bacteria, micro-organisms or plants being of the kind which produce signaling molecules in intercellular space. The method includes positioning a biosensor in the liquid or gaseous medium, the biosensor having a biolayer matched... Agent: Gowling, Lafleur Henderson LLP

20080145891 - Apparatus and method for processing histological specimens: Apparatuses for processing histological specimens are provided. One apparatus includes a cap that is placed on a vessel used for holding stains. The cap has a door through which a microscope slide and specimen can be inserted in order to apply stain thereon. Removal of the slide causes the door... Agent: J. Bennett Mullinax, Llc

20080145896 - Anti hiv-i bacterial and baculovirus recombinant epap-1: The invention relates to an anti HIV-1 active recombinant Epap-1 expressed in bacterial and baculovirus which significantly binds to gp120 of HIV-1 virus isolates.... Agent: The Webb Law Firm, P.c.

20080145892 - Genes and proteins for the biosynthesis of the glycopeptide antibiotic a40926: The present invention relates to the field of antibiotics, and more specifically to the isolation of nucleic acid molecules that code for the biosynthetic pathway of the glycopeptide antibiotic A40926. Disclosed are the functions of the gene products involved in A40926 production. The present invention provides biosynthetic genes that code... Agent: Pfizer Inc.

20080145893 - Method for producing a recombinant protein at high specific productivity, high batch yield and high volumetric yield by means of transient transfection: Recombinant proteins are of great commercial interest. Yet, most current production methods in mammalian cells involve the time- and labor-consuming step of creating stable cell lines. Production methods based on transient gene expression are advantageous in terms of speed and versatility, yet, thus far, those methods have not shown the... Agent: Markus Hildinger

20080145894 - Methods and materials for expression of a recombinant protein: Recombinant expression vectors are provided comprising a 3′UTR of a light chain and an Epstein-Barr virus origin of replication. Also provided are host cells comprising such vectors and methods of producing recombinant protein with such vectors. Additional methods of producing a recombinant protein involve contacting cells with a first and... Agent: Anne Dollard Xoma (us) Llc

20080145895 - Methods and materials for increasing expression of recombinant polypeptides: The present invention provides novel methods and materials for increasing the expression of recombinant polypeptides. Methods and materials of the invention allow increased expression of transcription units that include recombinant DNA sequences which encode polypeptides of interest. The present invention provides expression vectors which contain multiple copies of a transcription... Agent: Anne Dollard Xoma (us) Llc

20080145897 - Polymerase enhancing factor (pef) extracts, pef protein complexes, isolated pef protein, and methods for purifying and identifying: The invention provides novel extracts, proteins, and complexes that improve the polymerization activity of nucleic acid polymerases. Included within the aspects of the invention are methods for identifying compositions with a polymerase enhancing activity, methods for purifying and using these compositions, and specific extracts, proteins, and complexes that function to... Agent: Agilent Techologies Inc

20080145898 - Sequencing methods: The present teachings provide methods and compositions for sequencing one or more target nucleic acids. High levels of multiplexing are provided by the use of an emulsion PCR comprising primer-immobilized beads. The resulting reaction products can be sequenced by any of a variety of mobility-dependent analytical techniques, such as mass... Agent: Knobbe Martens Olson & Bear LLP

20080145899 - Production of oligosaccharides by microorganisms: The present invention relates to the enzymatic synthesis of oligosaccharides, including sialylated product saccharides. In particular, it relates to the use of recombinant cells to take up low cost precursors such as glucose, pyruvate and N-actyl-glucosamine, and to synthesize activated sugar moieties that are used in oligosaccharide synthesis. The methods... Agent: Townsend And Townsend And Crew, LLP

20080145900 - Process for hydrolyzing starch without ph adjustment: An alpha-amylase enzyme obtained from Bacillus acidocaldarius species is utilized to liquefy starch at a pH as low as 3.0 without the need to add thermostabilizing agents such as calcium. The alpha-amylase produces acceptable DE yields in a single liquefaction step and does not need to be inactivated prior to... Agent: Janet Kaiser Castaneda Genencor International, Inc.

20080145901 - Novel process for the preparation of 3,5-di-o-acyl-2-fluoro-2-c-methyl-d-ribono-gamma-lactone: The present invention provides novel methods for preparing a key intermediate, 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-γ-lactone (2), for the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-β-D-ribofuranosyl)cytosine (1), which is a potent and selective anti-hepatitis C virus agent.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20080145902 - Method for preparation of polyunsaturated fatty acid-containing phosphatidylserine: A method for the preparation of highly polyunsaturated fatty acid-containing phosphatidylserine and phosphatidic acid by phospholipase D-catalyzed transphosphatidylation of fish liver phosphatidylcholine and L-serine is disclosed.... Agent: Law Office Of Michael A. Blake

20080145903 - Processes of producing fermentation products: The invention relates to a process of fermenting plant material into a fermentation product using a fermenting organism, wherein one or more phytohormones are present during fermentation.... Agent: Novozymes North America, Inc.

20080145904 - Method for producing primary alcohols: The present invention relates to a process for the production of primary alcohols from aldehydes with the said of whole-cell catalysts or isolated enzymes. Employed are an alcohol dehydrogenase and an enzyme which is capable of regenerating the cofactor, where it is preferred to have a substrate concentration of >150... Agent: Fulbright & Jaworski, LLP

20080145905 - Cosmetics: Cosmetics containing an active component comprising lactic acid bacteria fermented rice obtained by fermenting rice with lactic acid bacteria; a skin brightening and caring agent comprising lactic acid bacteria fermented rice obtained by fermenting rice with lactic acid bacteria; and an emulsifier comprising as the main component lactic acid bacteria... Agent: Antonelli, Terry, Stout & Kraus, LLP

20080145906 - Methods of increasing lipolysis: Methods for increasing lipolysis in a cell are described herein. Such methods comprise the application of an electrical current to a cell. In an embodiment, the application of the electrical current does not substantially alter the viability of such cell and/or preserves the viability of such cell. In an embodiment,... Agent: Birch Stewart Kolasch & Birch

20080145907 - N-sulfonyldicarboximide containing tethering compounds: Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonyldicarboximide group... Agent: 3m Innovative Properties Company

20080145908 - Selective deposition of materials on contoured surfaces: m

20080145909 - Methods for avoiding contamination of negative sample material with analyte-containing samples when using pipetting robots: A method is disclosed for reducing the contamination of reaction containers which are empty or already fitted with analyte-free sampling material or sampling material having a low analyte concentration, inside a configuration of reaction containers which are spatially close to each other, when pipetting samples or reagents using an automatic... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080145910 - Stabilized compositions of thermostable dna polymerase and anionic or zwitterionic detergent: The present invention provides compositions, methods, and kits for protecting thermostable DNA polymerase during amplification reactions conducted at a temperature ranging from about 40° C. to greater than 100° C. The composition comprises a thermostable DNA polymerase and an anionic detergent or zwitterionic detergent.... Agent: Polsinelli Shalton Flanigan Suelthaus Pc

20080145911 - Photocontrol of sugar redox reactions: A method is described for modifying a redox reaction using selected non-ionizing radiation. In a model reaction, oxidation of a sugar such as glucose in the presence of glucose oxidase can be completely inhibited with a non-coherent excited state oxygen spectral energy wavelength.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080145912 - Endoglucanases: wherein, at position 3 of the first sequence, the amino acid is Trp, Tyr or Phe; at position 4 of the first sequence, the amino acid is Trp, Tyr or Phe; at position 8 of the first sequence, the amino acid is Arg, Lys or His; at positions 9, 10,... Agent: Novozymes North America, Inc.

20080145913 - Nucleic acid molecules encoding mismatch endonucleases and methods of use thereof: We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective amount of enzymes having strand cleavage activity, 3′ to 5′ exonuclease activity, and... Agent: Novici Biotech Llc

20080145914 - Subcutaneous administration of coagulation factor vii: The invention relates to the use of a Factor VIIa for the manufacture of a medicament for treatment of a condition affectable by Factor VIIa, said medicament being for subcutaneous, intramuscular or intradermal administration, and to the use of a Factor VIIa for the manufacture of a medicament for treatment... Agent: Novo Nordisk, Inc. Intellectual Property Department

20080145915 - Hepatitis c virus vaccine: The present invention relates to isolation of a novel Hepatitis C virus, more particularly, the present invention relates to a viral class Hepatitis C, polypeptides, polynucleotide, vaccine and antibodies derived there from.... Agent: Oliff & Berridge, Plc

20080145916 - Moraxella catarrhalis outer membrane protein-106 polypeptide, gene sequence and uses thereof: The invention discloses the Moraxella catarrhalis outer membrane protein-106 (OMP106) polypeptide, polypeptides derived therefrom (OMP106-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies that specifically bind the OMP106 polypeptide and/or OMP106-derived polypeptides. Also disclosed are immunogenic, prophylactic or therapeutic compositions, including vaccines, comprising OMP106 polypeptide and/or OMP106-derived polypeptides. The invention... Agent: Foley And Lardner LLP Suite 500

20080145917 - Method of degrading tbp using a photosynthetic bacterial strain: The invention relates to: a method of treating liquid waste (liquid agricultural or industrial effluents or aquatic sites) which is loaded or polluted with tributyl phosphate (TBP), modified bacterial strains which can be used in the aforementioned treatment method, a method for monitoring changes in TBP pollution, and the device... Agent: Alston & Bird LLP

20080145918 - Method for the detoxification of a hazardous compound: It is an object of the present invention to provide a method for the safe and effective detoxification of a hazardous compound containing the arsenic and or the like. The method for the detoxification of a hazardous compound according to the present invention is characterized in that the hazardous compound... Agent: Hamre, Schumann, Mueller & Larson, P.c.

20080145920 - Method of manufacturing a tissue-engineered prosthesis: Developing heart valves are exposed to dynamic strains by applying a dynamic pressure difference over the leaflets. The flow is kept to a minimum, serving only as a perfusion system, supplying the developing tissue with fresh nutrients. Standard heart valves were engineered based on B trileaflet scaffolds seeded with cells... Agent: Davis Wright Tremaine, LLP/seattle

20080145919 - Portable organ and tissue preservation apparatus, kit and methods: An organ and tissue preservation and transport apparatus comprising a chamber, a temperature control mechanism and a system monitor. A medium bathes an organ within the chamber. The temperature control mechanism adjusts the temperature of the medium. The system monitor receiving and records the temperature of the chamber.... Agent: Dunlap Codding & Rogers, P.c.

20080145921 - Tissue bath system with air heating: A tissue bath system with containers and sample holders for holding tissue sample inside tissue medium in the containers, where each sample holder is connected to a force transducer for measuring force exerted on the holder by contraction of the tissue sample upon stimulation. The system further comprises a temperature... Agent: Roberts, Mlotkowski & Hobbes

20080145922 - Device for performing analysis on cell cultures: A device (1) for the carrying out of investigations on cell cultures (2) which take place in a liquid culture medium (4). The device possesses at least a receptacle (3) to contain the culture medium (4) including the cell culture (2), wherein one or more sensors (6) for measurement of... Agent: Volpe And Koenig, P.c.

20080145923 - High throughput device for performing continuous-flow reactions: A high-throughput device is structured to perform a continuous-flow reaction, e.g., a polymerase chain reaction (PCR) requiring repetitive temperature control in a timely fashion.... Agent: Sughrue Mion, Pllc

20080145924 - Cell culture apparatus and control method thereof: A cell culture apparatus is provided in which a plurality of culture vessels can be mounted and removed in a set, which has a regulation mechanism that can fix each culture vessel in the correct position, and which enables suppression of production costs. The cell culture apparatus has one or... Agent: Stanley P. Fisher Reed Smith LLP

20080145925 - Cell culture chamber: A cell culture chamber includes: a top compartment and a bottom compartment that are separated by a semi-permeable membrane inside a supporting body; a culture solution supply flow path that supplies culture solution to an interior of the bottom compartment; a culture solution discharge flow path that discharges culture solution... Agent: Kenyon & Kenyon LLP

20080145926 - Reactor and reactor unit with hollow fibers: This invention relates to a reactor unit with a first chamber and a second chamber, wherein the first chamber is formed by the interior of a housing and wherein the second chamber is formed by the interior of a plurality of hollow fibers arranged in the housing. The hollow fibers... Agent: Jacobson Holman Pllc

20080145927 - Stresscopins and their uses: The invention provides novel nucleic acids and polypeptides, referred to herein as stresscopin 1 and stresscopin 2, which preferentially activate the CRH-R2 receptor over the R1 receptor. Stresscopins, analogs and mimetics, and related CRH-R2 agonists suppress food intake and heat-induced edema; but do not induce substantial release of ACTH. Stresscopin... Agent: Bozicevic, Field & Francis LLP

20080145928 - Factor taking part in transcription control: HDART binds with HDAC (histone deacetylase) and function as a repressor. HDART directly binds with Skip functioning as a transcription co-activator of a nuclear receptor to repress the transcription of the nuclear receptor. Moreover, HDART is one of transcription co-repressors of nuclear receptor, and binds with HDAC thereby enabling intense... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080145929 - Method for the preparation of a dermal papilla tissue having hair follicle inductive potency: The inventive method for the preparation of a dermal papilla tissue in accordance with the present invention makes it possible to form a quantity of the dermal papilla tissues having hair follicle inductive ability, and accordingly, it can be effectively used for the treatment of alopecia through cell transplantation.... Agent: Sughrue Mion, Pllc

20080145930 - Methods and compositions for reanimating cryopreserved oocytes: Disclosed are methods and compositions useful for thawing cryopreserved oocytes and, in particular, mammalian oocytes such as human oocytes.... Agent: Foley & Lardner LLP

20080145931 - Mature dendritic cell compositions and methods of culturing same: This invention provides methods to prepare and use immunostimulatory cells for enhancing an immune response. The invention provides a method for preparing mature dendritic cells (DCs), comprising the sequential steps of: (a) signaling isolated immature dendritic cells (iDCs) with a first signal comprising an interferon gamma receptor (IFN-γR) agonist and/or... Agent: Merix Bioscience, Inc.

20080145932 - Method and apparatus for cell recovery: A method and apparatus for recovering cells from stool are provided for diagnosing colorectal cancer from stool naturally voided by multiple specimens. The method includes the steps of preparing a sample of naturally voided and collected stool, to which sample a buffer solution is added, causing cancer cells in the... Agent: Antonelli, Terry, Stout & Kraus, LLP

20080145933 - Systems and methods for parenterally procuring bodily-fluid samples with reduced contamination: The present invention is directed to the parenteral procurement of bodily-fluid samples. The present invention is also directed to systems and methods for parenterally procuring bodily-fluid samples with reduced contamination from dermally-residing microbes. In some embodiments, a bodily-fluid withdrawing system is used to withdraw bodily fluid from a patient for... Agent: Darby & Darby P.c.

20080145934 - Tissue-engineering scaffolds containing self-assembled-peptide hydrogels: The present invention is directed to tissue-engineering scaffolds containing both a microporous scaffold made from a biocompatible material suitable for use in tissue-engineering scaffolds and a nanofiberous, nanoporous hydrogel formed from a self-assembling peptide, where at least a portion of the hydrogel is disposed within the pores of the microporous... Agent: Woodcock Washburn LLP

20080145936 - Control of es cell self renewal and lineage specification, and medium therefor: Self renewal of pluripotent cells in culture is promoted using a combination of an activator of a signalling pathway downstream of a receptor of the TGF-β superfamily and an activator of a gp130 downstream signalling pathway.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080145935 - Mutant receptors and their use in a nuclear receptor-based inducible gene expression system: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a... Agent: Sughrue Mion, Pllc

20080145937 - In vivo transformation of pancreatic acinar cells into insulin-producing cells: The present invention includes compositions and methods for transforming cells into glucose-responsive, insulin-production cells using a construct that expresses betacellulin and PDX1, e.g., transforming pancreatic acinar cells using one or more expression vectors that expressed betacellulin and PDX1 using ultrasound targeted microbubble destruction (UTMD).... Agent: Chalker Flores, LLP

20080145938 - Buffer solution for electroporation and a method comprising the use of the same: A buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce the biologically active molecules into the cells using electric current. The buffer solution includes HEPES and at least 10 mmol*1−1 magnesium ions (Mg2+). The buffer solution has a buffer capacity of... Agent: Darby & Darby P.c.

20080138791 - Compositions and methods for prolonging survival of platelets: The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical composition containing the modified platelets and for administering the pharmaceutical composition to a mammal to... Agent: Foley & Lardner LLP

20080138790 - Methods and compositions for simultaneously isolating hemoglobin from red blood cells and inactivating viruses: The present invention relates to methods arid compositions for isolating hemoglobin from red blood cells. Such methods and compositions also facilitate viral inactivation in a manner that allows recovery of biologically active hemoglobin. More particularly, this method relates to the use of solvents and detergents that are capable of facilitating... Agent: Gordon & Rees LLP

20080138792 - Vasodilator eluting medical devices with a specific polyphosphazene coating and methods for their manufacture and use: The present invention is directed to medical devices in which flow is channeled of blood and blood products for the purpose of effecting a chemical exchange to remove desired chemicals from the blood or blood products, and to impart nitric oxide, other smooth muscle relaxant compounds, or other desired chemicals... Agent: Sutherland Asbill & Brennan LLP

20080138793 - Method for cholesterol determination: The present invention relates to a sampling device for taking up a blood sample and for providing the blood sample for analysis of total cholesterol in said blood sample. The device comprises a receiving cavity for receiving, through capillary action, the blood sample to be analysed, said receiving cavity having... Agent: Buchanan, Ingersoll & Rooney Pc

20080138794 - Method for detecting or measuring hbv: A Method for detecting hepatitis B virus as well as a kit and a reagent therefor, comprising using a phosphate buffer that specifically binds to hepatitis B virus, for example a monoclonal antibody that specifically binds to a specific site of core-related protein of hepatitis B virus.... Agent: Foley And Lardner LLP Suite 500

20080138795 - Use of intramolecularly, covalently cross-linked proteins as binding partners in immunoassays: The invention concerns the use of intramolecularly, covalently cross-linked proteins and covalently cross-linked reverse transcriptase from HIV as immunological binding partners in immunoassays. It also concerns immunological test procedures for detecting an analyte in a sample in which intramolecularly, covalently cross-linked proteins are used as binding partners, and it further... Agent: Barnes & Thornburg LLP (roche)

20080138823 - Biochip for archiving and laboratory-medical analysis of biological smple material, process for its production, and its use in diagnostic methods: A biochip for diagnostic purposes comprises a sample carrier made of a solid matrix, on the surface of said sample carrier is bound the sample material to be analysed which originates from a biological organism.... Agent: Birch Stewart Kolasch & Birch

20080138810 - Biomarker for gestational trophoblastic disease: A relatively specific trophoblastic-associated biomarker, HSD3B1, is disclosed. A method for screening gestational trophoblastic disease using HSD3B1 is also disclosed.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20080138806 - Biomarkers and detection methods for gastric diseases: The present invention provides a biomarker for detecting gastric diseases, especially gastric cancer selected from: a nucleic acid sequence of GroES, complementary strand, or derivatives thereof or an amino acid sequence of GroES, derivatives, fragments or variants thereof or antibodies against said amino acid sequences or combinations thereof, yet provides... Agent: Bacon & Thomas, Pllc

20080138804 - Buffer composition: The invention provides compositions for improving the accuracy of a sequencing-by-synthesis reaction by minimizing the incorporation of unlabeled dNTPs.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080138826 - Compositions and methods for assaying herg channel binding: The present invention provides compositions and methods useful for assaying binding of compounds to the hERG K+ channel. According to a method of the present invention, a compound of interest is added to the hERG K+ channel in the presence of a selenium analog of a competitive inhibitor of the... Agent: Peters Verny , L.l.p.

20080138814 - Compositions and methods for modulation of ksr1 and ksr2 interactions: Materials and methods for identifying agents which modulate KSR mediated signal transduction are provided.... Agent: Dann, Dorfman, Herrell & Skillman

20080138797 - Detection systems and methods: Detection systems and methods of their use are provided. An exemplary system comprises a chamber for holding culture media, the chamber having a cellular attachment surface, and a detector disposed in the chamber comprising a surface modified with a binding agent for binding a target substance wherein the detection system... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20080138822 - Differentiating nucleic acids with ultraviolet radiation: A method of using ultraviolet radiation to differentiate nucleic acids (DNA, RNA) with particular application to forensic science. The illustrative embodiment shows an ultraviolet radiation reactor made of a block (10) fitted with an optical chamber (12) and sample tube insertion hole (14). A UV light source (16) is fitted... Agent: Roy L. Rike

20080138813 - Dyslipoproteinemia associated with venous thrombosis: The present invention provides methods of determining a human subject's risk for venous thrombosis based on the finding that venous thrombosis patients have significantly lower levels of large HDL particles, HDL-cholesterol and apolipoprotein AI and higher levels of small LDL particles, LDL-cholesterol and apolipoprotein B. Genotyping showed that venous thrombosis... Agent: Morgan & Finnegan, L.l.p.

20080138802 - Gene detection method and gene detection apparatus: There are provided a gene detection method and an apparatus thereof, for detecting a gene having a specific sequence in a specimen with high sensitivity. The gene detection method comprises a gene sample conformation step of conforming a gene sample by denaturing a gene to be detected in the specimen... Agent: Wenderoth, Lind & Ponack L.l.p.

20080138818 - Gene reporter assay, kit and cells with improved sensitivity and/or specificity for determining the level of an extracellular signal: The present invention provides a reporter gene containing cell line with increased specificity and/or sensitivity for a particular extracellular signal of interest so that it can be used in a gene-reporter assay to accurately determine the presence and/or level of the extracellular signal of interest in the presence of other... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080138805 - Isolation, gene expression, and chemotherapeutic resistance of motile cancer cells: Methods of isolating motile cells of interest from an animal tissue is provided. Also provided are methods of determining mRNA or protein expression of a gene in motile cells of interest from an animal tissue. Additionally, methods of determining whether a cancer in a tissue of a mammal is likely... Agent: Amster, Rothstein & Ebenstein LLP

20080138799 - Method and a system for extracting a genotype-phenotype relationship: At least one genotype-phenotype relationship is extracted based on genotype data of a group of genes for different organisms of a group of organisms. A first database stores genotype data of each organism of the group of organisms. For each organism a genotype vector is stored having a vector component... Agent: Staas & Halsey LLP

20080138819 - Method for detection of melanoma: The present invention provides non-invasive methods for detecting, monitoring, staging, and diagnosing malignant melanoma in a skin sample of a subject. The methods include analyzing expression in skin sample of one or more melanoma skin markers. The melanoma skin markers include IL-1 RI, endothelin-2, ephrin-A5, IGF Binding Protein 7, HLA-A0202... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper Us LLP

20080138820 - Method for determining genotoxicity: Disclosed are compositions and methods which provide an integrated approach to genotoxicity assessment procedures by employing a genetically engineered cell line to report on a number of key indicators of genotoxicity effects and mechanisms. Imaging and analysis of cells exposed to test agents allows automated analysis using high content cellular... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20080138807 - Method for identifying gene with varying expression levels: This invention relates to a method for searching for a genetic polymorphism for identifying a gene whose expression level is different between alleles and to a method for searching for a phenotype-associated genetic polymorphism. More particularly, the invention relates to a method for effectively identifying a gene whose expression level... Agent: Foley And Lardner LLP Suite 500

20080138803 - Method of detecting cystic fibrosis associated mutations: The present invention describes a method for the simultaneous identification of two or more single base changes, insertions, deletions or translocations in a plurality of target nucleotide sequences that are markers associated with cystic fibrosis. Multiplex detection is accomplished using multiplexed tagged allele specific primer extension (ASPE) and hybridization of... Agent: Goodwin Procter LLP Patent Administrator

20080138815 - Method of loading sample into a microfluidic device: A method comprising loading a sample into a microfluidic device which comprises plural sample chambers, subdividing the sample into a plurality of sample portions, such that respective sample portions are positioned in each of a plurality of the sample chambers, and subjecting the sample portions loaded into the respective sample... Agent: Burr & Brown

20080138825 - Methods and compositions for selectively cleaving dna containing duplex nucleic acids in a complex nucleic acid mixture, and nuclease compositions for use in practicing the same: Methods of selectively cleaving DNA containing duplex nucleic acids in a complex nucleic acid mixture, as well as nuclease containing compositions for use therein, are provided. In the subject methods, a nuclease or composition thereof is employed to provide for selective cleavage of DNA containing duplex nucleic acids in a... Agent: Bozicevic, Field & Francis LLP

20080138824 - Methods and kits for determining sperm cell number: A flow cytometry method and kit is provided for quantifying an absolute number of mature sperm cells in a semen sample, the method comprising (a) determining a total particle number (T); (b) determining a number of DNA comprising particles (D); (c) determining a number of cells which are not mature... Agent: Martin D. Moynihan Prtsi, Inc.

20080138808 - Methods for identification of sepsis-causing bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of sepsis-causing bacteria by molecular mass and base composition analysis.... Agent: Casimir Jones, S.c.

20080138816 - Methods for preparing and analyzing cells having chromosomal abnormalities: The present invention provides methods for preparing cells with highly condensed chromosomes, such as sperm, and methods for detecting and quantifying specific cellular target molecules in intact cells. Specifically, methods are provided for detecting chromosomes and chromosomal abnormalities, including aneuploidy, in intact cells using fluorescence in situ hybridization of cells... Agent: Seed Intellectual Property Law Group Pllc

20080138809 - Methods for the diagnosis of fetal abnormalities: The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a... Agent: Wilson Sonsini Goodrich & Rosati

20080138800 - Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection: The invention provides methods and processes for the identification of polymorphisms at one or more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site.... Agent: Eric P. Mirabez

20080138817 - Novel functional peptide nucleic acid monomer and process for producing the same: e

20080138821 - Process for prognosis of disease using gene gna11: The invention relates to the use of a genomic gene modification in the gene for the Gα11 subunit of human G-proteins which sub-unit is encoded by the gene GA11, for the prognosis of disease risks, disease developments and the response to disease therapies by pharmacological and non-pharmacological measures and for... Agent: Amster, Rothstein & Ebenstein LLP

20080138798 - Reference markers for biological samples: The present invention provides methods, compositions and kits that include reference markers in biological samples. The reference samples can be marked with DNA oligomers that can be derived from sequences that do not to exist in the human genome. These sequences can be determined by an algorithm used to search... Agent: Dykas, Shaver & Nipper, LLP

20080138812 - Screening method for competitive hiv rt inhibitors: The present invention is directed to methods for identifying a specific class of competitive inhibitors of HIV reverse transcriptase that act differently from known reverse transcriptase inhibitors.... Agent: Philip S. Johnson Johnson & Johnson

20080138801 - Surface plasmon resonance sensor for detecting changes in polynucleotide mass: The present invention provides methods for detecting nucleic acids by generating mass changes in a ligand on an SPR surface through target-dependent enzymatic reaction.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080138811 - Tissue-based assay system for alzheimer-specific degeneration and pathology: The present invention relates to modified brain slice cultures and assay systems based thereon. In particular, the invention relates to a tissue-based assay system for screening agents capable of modulating etiopathology of neuronal cells, in particular in the context of Alzheimer's disease related brain lesions.... Agent: Cermak Kenealy & Vaidya LLP

20080138827 - Agent for predicting and judging the recurrence after treating liver cancer: A method for prognosing possible recurrence after treatment of the liver cancer, characterized by measuring GPC3 contained in a test sample by use of an anti-GPC3 antibody.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080138832 - Diagnosis of sepsis or sirs using biomarker profiles: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of... Agent: David W. Highet, Vp & Chief Ip Counsel Becton, Dickinson And Company

20080138831 - Immunological assay and chip: The present invention provides an immunological assay suitable to be carried out on a chip. After an antigen-antibody complex in which an antigen to be measured and an antibody have bound to each other was obtained in a reaction chamber, the reaction chamber is washed using a sample solution and... Agent: Mcdermott Will & Emery LLP

20080138829 - Method for detecting and/or determining the concentration of at least one ligand: The invention relates to a method for detecting and/or determining the concentration of a ligand contained in a solution to be analyzed, during which a receptor, which can enter into a specific bond with the ligand, is immobilized on a semiconductor chip at a test location. In order to bind... Agent: The Webb Law Firm, P.c.

20080138830 - Method for measuring proinsulin and c-peptide and a kit therefor: Methods to determine the concentrations in a sample of proinsulin and of molecules comprising C-peptide are disclosed. The concentrations are determined within the same reaction compartment and using only one capture antibody, specific for an epitope within C-peptide. Kits are disclosed for use in the disclosed methods. Methods to determine... Agent: Knobbe Martens Olson & Bear LLP

20080138833 - Methods and compositions for assessing il-12 or the neutralization of il-12 in a sample: Methods for detecting the presence or amount of Interleukin-12 (IL-12), particularly human IL-12, or antibodies that neutralize the activity of human IL-12 in a human biological sample, involve incubating the biological sample with an NK cell line or progeny thereof. A correlation is determined between the presence or amount of... Agent: Howson And Howson/wyeth Cathy A. Kodroff

20080138828 - Microgravity bioreactor systems for production of bioactive compounds and biological macromolecules: The present invention relates to compositions and methods of plant, fungal and bacterial cell culture that can be effectively utilized for three-dimensional plant, fungal, and bacterial cell growth and production of bioactive compounds of interest. The culture methods employ a microgravity environment such that rapid establishment and expansion of cells... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080138834 - Cellular antagonists of gpcr physiology: The present invention provides a new approach for the treatment of G-protein coupled receptor based disease. This approach comprises altering the physiology of G-protein coupled receptor based responses by exerting chemical control over the cellular distribution of the receptor. This approach allows a method for phenotypic screening for candidate compounds... Agent: Edwards Angell Palmer & Dodge LLP

20080138837 - Methods and kits for detecting and measuring adamts13/fxi complexes: Provided are assays and kits to detect ADAMTS13 activity using peptide substrates and ADAMTS13/Factor XI complexes using ELISA. These assays and kits can be used for diagnostic applications and to evaluate treatment of thrombotic or hemostatic disorders, for example, thrombotic thrombocytopenic purpura (TTP). Also provided is a novel form of... Agent: Frommer Lawrence & Haug

20080138838 - Diagnosis of zd1839 resistant tumors: Described herein are genes whose expression are regulated in specific cancers. Related methods and compositions that can be used for diagnosis of those cancers are disclosed. Also described herein are methods that can be used to identify modulators of selected cancers.... Agent: Davis Wright Tremaine LLP/los Angeles

20080138840 - Assay for antibodies to mycobacterium paratuberculosis: A method of detecting an immune response to a paratuberculosis-specific antigen, comprising incubating a sample from a subject with the paratuberculosis-specific antigen and detecting the presence of an antibody in the sample as an indication of an immune response to the paratuberculosis-specific antigen. The antigen may be obtained from a... Agent: Brinks Hofer Gilson & Lione

20080138839 - Methods for ionophorically screening pore forming bacterial protein toxins and receptors: One embodiment of the present invention is directed to methods for ionophorically screening pore forming bacterial protein toxins and receptors. The method includes: a) forming a membrane comprising a lipid and a receptor, b) contacting the membrane with the pore forming bacterial protein toxin and an ion solution, and c)... Agent: Dinsmore & Shohl, LLP

20080138841 - Monitoring system for sensing microorganisms: A monitoring system comprising a sensing means operable to sense a prescribed microorganism in a prescribed environment and a human interfacing means, wherein the sensing means comprises means for emitting UV light and measuring resulting emissions from microorganisms, and the human interfacing means is operatively coupled to the sensing means... Agent: James C. Wray

20080138836 - Kinase and ubiquination assays: Compositions, including antibodies, polypeptides, and organic molecules, kits, and methods for probing molecular interactions (e.g., deubiquination, ubiquination and kinase activity) using resonance energy transfer (RET) are provided.... Agent: Invitrogen Corporation C/o Intellevate

20080138835 - Mutants of staphylococcal mrs and methods of use: Mutant bacterial MRS nucleic acids and proteins are provided, as well as uses for the nucleic acids and proteins, such as in a high-throughput screen for inhibitors of the mutant proteins.... Agent: Swanson & Bratschun, L.l.c.

20080138842 - Indirect lateral flow sandwich assay: Disclosed herein are indirect lateral flow sandwich assays, in which the target analyte binds an analyte-specific reagent comprising a first member of a conjugate pair, forming a complex which contacts and binds a colored particulate label comprising a complementary member of said conjugate pair, forming a second complex. Capture of... Agent: Genzyme Corporation Legal Department

20080138843 - Method for determining the total clotting activity of a blood or plasma sample: The invention relates to a method for determining the total clotting activity of a blood or plasma sample, characterized in that a highly specific, not irreversible thrombin inhibitor is added to a blood or plasma sample in a defined amount, the clotting of the blood or plasma sample is induced... Agent: Edwards Angell Palmer & Dodge LLP

20080138844 - Methods for diagnosis and monitoring of neurological disease by detection of an encephalotoxin: Encephalotoxin produced by activated mononuclear phagocytes is present in individuals having neurological disease including neurodegenerative and neuro-inflammatory diseases, such as Alzheimer's disease (AD), HIV-1-associated dementia (HAD), Creutzfeldt-Jakob disease, Mild Cognitive Impairment, prion disease, minor cognitive/motor dysfunction, acute stroke, acute trauma, or neuro-AIDS. Biochemical detection of encephalotoxin according to the methods... Agent: Woodcock Washburn LLP

20080138846 - Method for analysis of albumin in sample solution: The present invention provides a method of analyzing albumin in a sample solution, which is characterized by pretreating a sample solution before subjecting the sample solution to mass spectrometry or liquid chromatography. The present invention further provides a method of accurately and stably analyzing the amount and ratio of oxidized... Agent: Cermak & Kenealy LLP Acs Llc

20080138845 - Method of de novo sequencing of peptide using the maldi mass spectrometry, method and apparatus for preparing sample for maldi mass spectrometry: The present invention relates to a method of peptide sequencing by MALDI (matrix-assisted laser desorption ionization) tandem mass spectrometry, which comprises the steps of chemically modifying a sample peptide with at least one chemical modification method selected from the group consisting of guanidination and esterification in order to change the... Agent: Lexyoume Ip Group, Llc

20080138847 - Bcl-2 family member and bh-3 only proteins for use in development of peptidomimetics: Embodiments of the present invention relate to the molecular interactions of Bcl-2 family members. The design of peptidomimetics that discriminate between anti-apoptotic and pro-apoptotic Bcl-2 family members and uses the same to modulate apoptosis are described herein.... Agent: Pepper Hamilton LLP

20080138848 - Microfluidic device and method of using same: The invention relates to a microfluidic device comprising one or more fluid channels, one or more fluid ports, and a V-shaped particle retention structure. The fluid channel is generally opposite the particle retention structure, fluid ports are located between the fluid channel and the particle retention structure, and the particle... Agent: Oyen, Wiggs, Green & Mutala LLP 480 - The Station

20080138850 - Skin model: The present invention relates to the use of a pig skin sample as a skin model, particularly for the assessment of pharmacological and cosmetic effects.... Agent: Connolly Bove Lodge & Hutz, LLP

20080138849 - Use of mdck cell line to predict corneal penetration of drugs: A new method of evaluating the ability of drug molecules to penetrate the cornea is described. The permeation rate of the drug molecules in MDCK cells is utilized to predict the ability of the molecules to penetrate the cornea. The method is useful for in vitro screening of potential new... Agent: Alcon

20080138851 - Trophic conversion of obligate phototrophic algae through metabolic engineering: Most microalgae are obligate photoautotrophs and their growth is strictly dependent on the generation of photosynthetically-derived energy. In this study it is shown that the microalga Phaeodaclylurn tricornutum can be engineered to import glucose and grow in the dark through the introduction of genes encoding glucose transporters. Both the human... Agent: Hunton & Williams LLP Intellectual Property Department

20080138852 - Identification of blood elements using inverted microscopy: A method of identifying the elements of a blood sample including placing an aliquot of blood on a transparent substrate such as a coverslip. The blood is allowed to stand and the cells to settle to form a layer or matrix. Inverted microscopy is used to identify the elements in... Agent: Gauthier & Connors LLP

20080138853 - Method for evaluating the degree of maturity of corneocytes: Disclosed is an evaluating method for the properties of a corneocyte in a horny layer sample originating in the skin. In the above method, detected and evaluated are selective staining of a cornified envelope in a corneocyte, selective staining of a nuclear component and the antigenicity.... Agent: Wenderoth, Lind & Ponack, L.l.p.

20080138854 - Biopsy support with sectionable resilient cellular material: A histologic tissue sample support device includes a tissue support formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. A resilient cellular material is coupled to the tissue support and is configured... Agent: Wood, Herron & Evans, LLP

20080138856 - Enzymatic enantioselective ester or amide hydrolysis or synthesis: The enantioselectivity of fungal lipolytic enzymes can be altered by substituting a suitably selected amino acid residue. The residue to be substituted is selected from its location in the 3D structure of the enzyme and an ester substrate (or a substrate analogue). A residue in the lid may be selected... Agent: Novozymes North America, Inc.

20080138855 - Glycoprotein synthesis and remodeling by enzymatic transglycosylation: A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an activated oligosaccharide moiety, in the presence of a catalyst comprising endoglycosidase (ENGase), to... Agent: Moore & Van Allen Pllc

20080138857 - Methods of in vitro protein synthesis: Biological macromolecules are synthesized in vitro under conditions wherein oxidative phosphorylation is activated.... Agent: Bozicevic, Field & Francis LLP Stanford University Office Of Technology Licensing

20080138858 - Expression system for recombinant human arginase i: A novel recombinant protein expression system is provided for improving expression of recombinant human arginase I. The system contains an isolated and purified nucleic acid molecule for constructing plasmid and E. coli strain in order to improve the expression of recombinant human arginase I. In another aspect of the present... Agent: Eagle Ip Limited

20080138860 - Method for improving antibody: The present invention provides for a method for improving properties of an antibody such as an expression level and stability. A method for obtaining an antibody with an improved expression level and/or stability by modifying a human antibody or a humanized antibody, characterized by that at least any one of... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080138859 - Novel promoter nucleic acid derived from corynebacterium genus bacteria, expression cassette comprising the promoter and vector comprising the cassette, host cell comprising the vector and method for expressing a gene using the cell: Provided are a promoter including at least one polynucleotide selected from the group consisting of SEQ ID NOS: 1 to 7, an expression cassette including the same, a vector including the expression cassette, a host cell including the vector, and a method of expressing a gene using the host cell.... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080138861 - Production of attenuated respiratory syncytial virus vaccines involving modification of m2 orf2: Recombinant respiratory syncytial virus (RSV) are provided in which expression of the second translational open reading frame encoded by the M2 gene (M2ORF2) is reduced or ablated to yield novel RSV vaccine candidates. Expression of M2 ORF2 is reduced or ablated by modifying a recombinant RSV genome or antigenome to... Agent: Birch, Stewart, Kolasch & Birch, LLP

20080138862 - Enzymatic hydrolysis of biomasses having a high dry matter (dm) content: The present invention relates to a process for liquefaction and saccharification of polysaccharide containing biomasses, having a relatively high dry matter content. The present invention combines enzymatic hydrolysis with a type of mixing relying on the principle of gravity ensuring that the biomasses are subjected to mechanical forces, primarily shear... Agent: Budde, Schou & Ostenfeld, A/s

20080138863 - Methods for cloning nucleic acids in a desired orientation: The present invention provides highly accurate methods for cloning nucleic acids in a desired, pre-defined orientation, and additionally provides for a library of cloned oriented nucleic acids. The ability to control the orientation of a nucleic acid being cloned is highly important in various molecular biology applications.... Agent: Cooper & Dunham, LLP

20080138864 - Starch process: The present invention relates, inter alia, to the use of a glucoamylase derived from Talaromyces sp. and an acid alpha-amylase comprising a carbohydrate-binding module in a starch saccharification process in which starch is degraded to glucose.... Agent: Novozymes North America, Inc.

20080138796 - Nrif3, a novel co-activator for nuclear hormone receptors: Nucleic acids encoding NRIF3 are described. Polypeptides having amino acid sequences of NRIF3 proteins are also provided. A method is also provided for isolating and cloning NRIF3 cDNA. NRIF3 is useful in development/implementation of high throughput screens to identify novel thyroid hormone receptor (TR) and retinoid X receptor (RXR) agonists... Agent: Darby & Darby P.c.

20080138865 - Optimisation of culture conditions for production and process of purification of high molecular weight hyaluronic acid: The present invention provides an efficient and improved process for the production and purification of high molecular weight hyaluronic acid (HA). One embodiment relates to providing growth conditions for production of high molecular weight HA in Streptococcus zooepidemicus. For example, growth in medium comprising a lower protein concentration, e.g., 1%... Agent: Foley And Lardner LLP Suite 500

20080138866 - Process for the preparation of (r)-4,4-dialkoxy-pyran-3-ols such as (r)-4,4-dimethoxy-pyran-3-ol: The present invention is concerned with novel processes for the preparation of (R)-4,4-dimethoxy-pyran-3-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity including CCR2 antagonists.... Agent: Merck And Co., Inc

20080138867 - Continuous process and apparatus for enzymatic treatment of lipids: A method and system for the enzymatic treatment of a lipid containing feedstock comprises contacting the feedstock with a processing aid, then causing the feedstock to pass at a substantially constant flow rate through a treatment system comprising a plurality of enzyme-containing fixed bed reactors connected to one another in... Agent: Sandra B. Weiss Jones Day

20080138868 - Mutant delta-8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids: The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 ω-3, ETrA] to eicosatetraenoic acid [20:3 ω-3, ETA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ8 desaturase... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080138869 - Novel supported catalyst systems: The present invention relates to a supported catalyst system. The supported catalyst of the present invention comprises an inorganic support having attached to at least one surface thereof non-acidic, hydrophillic, hydroxyl-containing organic R10 groups having no or substantially no surface charge in solution, and at least one linker capable of... Agent: W.r. Grace & Co.-conn.

20080138870 - Solvent tolerant microorganisms: Pediococcus bacteria having enhanced tolerance to butanols have been isolated. The bacteria are useful for the fermentative production of butanol.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080138871 - Fermentation product production processes: The present invention relates to a process for producing a fermentation product from starch-containing material, comprising liquefying said starch-containing material with an alpha-amylase; treating with a protease; saccharifying in the presence of a carbohydrate-source generating enzyme; fermenting in the presence of a fermenting organism.... Agent: Novozymes North America, Inc.

20080138872 - Processes for producing fermentation products: The present invention provides a process of producing a fermentation product comprises the steps of i) pre-treating lignocellulosic material to release or separate cellulose, hemi-cellulose and/or lignin, ii) subjecting the pre-treated material to a cellulase, iii) fermenting in the presence of a fermenting organism, wherein xylose isomerase is added in... Agent: Novozymes North America, Inc.

20080138874 - Breeding method of lipid producing fungi and use of such a method: A method of breeding a lipid-producing strain belonging to the genus Mortierella. According to the method of breeding a lipid-producing strain which involves an expression-inhibiting step of inhibiting the expression of a specific gene in the lipid-producing strain as described above, a lipid-producing strain belonging to the genus Mortierella can... Agent: Drinker Biddle & Reath (dc)

20080138875 - Method to generate fungal biomass from a culture of differentiated mycelium: The present invention provides method to produce fungi biomass from mycelia comprising inoculating differentiated cells or mycelia into a culture medium which contains at least NaNO3, KH2PO4, MgSO4, KCl, and a source of carbon. This method also includes incubation of said culture under a specific wave length in a specially... Agent: John J. Martinez Md. Jd.

20080138873 - Yeast strains with improved fructose fermentation capacity: The present invention relates to yeast strains with improved carbohydrate fermentation capacity, in particular to strains transformed with a gene encoding an improved hexose transporter gene, more in particular a mutated HXT3 gene.... Agent: Nixon & Vanderhye, Pc

20080138876 - Transfection in electronically driven continuous flow: Biological cells and other membranous structures are transfected in a flow-through system by using a moving charge pattern on a longitudinal wall of a channel to cause the cells to travel through the channel due to an electrostatic interaction between the cells and the moving charge pattern. As the cells... Agent: Townsend And Townsend And Crew, LLP

20080138877 - Apparatus and method for electroporation of biological samples: The present invention relates to methods and apparatus for the encapsulation of biologically-active substances in various cell populations. More particularly, the present invention relates to a method and apparatus for the encapsulation of biologically-active substances in various cell populations in blood by electroporation to achieve therapeutically desirable changes in the... Agent: Fulbright & Jaworski L.l.p.

20080138878 - Novel hot start nucleic acid amplification: Methods and compositions for performing nucleic acid duplication and amplification reactions are provided. A single-stranded nucleic acid binding protein is selected and provided in the reaction mixture which is assembled at a low, nonstringent temperature to include all of the necessary reagents for successful nucleic acid duplication or amplification reactions.... Agent: Pearne & Gordon LLP

20080138879 - Method for controlled release of enzymatic reaction components: Compositions and reaction kits are provided for controlling an enzymatic process. The compositions and kits include a substantially water-insoluble, water-permeable polymer and a poorly water-soluble salt of an essential ionic enzymatic reactant. The disclosed compositions and methods are particularly useful for improving the specificity and performance of PCR.... Agent: Brinks Hofer Gilson & Lione

20080138880 - Family 44 xyloglucanases: The present invention relates to xyloglucanases belonging to family 44 of glycosyl hydrolases and having a relative xyloglucanase activity of at least 30% between pH 5 and pH 8 are derived from the genus Paenibacillus, especially from a strain of Paenibacillus polymyxa or Paenibacillus sp. The xyloglucanases exhibit high performance... Agent: Novozymes North America, Inc.

20080138881 - Microorganism culture device and microorganism culture medium comprising the same: A microorganism culture device comprising a porous matrix layer having a basis weight of 40 to 100 g/m2 and an air permeability of 7 to 24 cm/sec, and at least one layer of a water-soluble polymer layer laminated with the matrix layer.... Agent: Merchant & Gould Pc

20080138882 - Microorganism of escherichia sp, or corynebacterium sp, comprising foreign nadp dependent glyceraldehyde-3-phospate dehydrogenase gene and method for prodicing l-lysine using the same: Provided are an Escherichia species microorganism and Corynebacterium species microorganism that are transformed with a foreign NADP dependent glyceraldehydes-3-phosphate dehydrogenase gene and have the ability to produce L-lysine and a method of producing L-lysine using the microorganisms.... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080138883 - Method for bioremediation and biodegradable product therefor: A product for bioremediation, comprising a biodegradable carrier and a tablet or powder consisting essentially of microorganisms capable of digesting hydrocarbons, an inert material, and optionally trace oil in an amount sufficient to maintain the microorganisms in a dormant state, said microorganisms located entirely within said biodegradable carrier, and wherein... Agent: Birch Stewart Kolasch & Birch

20080138885 - Method and device for the anaerobic fermentation of organic material: Method for the anaerobic fermentation of organic material, whereby the organic material to be fermented is put in a fermentation tank (1) together with an inoculant and moves or is moved from an inlet (6) of the fermentation tank (1) to an outlet (9) thereof, whereby the fermented material is... Agent: Bacon & Thomas, Pllc

20080138884 - Method for separating and purifying nucleic acid: A method for separating and purifying nucleic acid, the method comprising: (1) a step of contacting a sample solution containing nucleic acid with a solid phase to adsorb the nucleic acid on the solid phase; (2) a step of contacting a washing solution with the solid phase to wash the... Agent: Birch Stewart Kolasch & Birch

20080138886 - Upstream and a downstream purification process for large scale production of plasmid dna: Methods of isolating clinical-grade plasmid DNA from manufacturing processes, including large-scale fermentation regimes, are disclosed which encompass alternatives to two core unit operations common to plasmid DNA purification processes. The novel upstream and downstream purification processes disclosed herein provide for reduced production costs and increase process robustness. Either or both... Agent: Merck And Co., Inc

20080138887 - Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.... Agent: Kilyk & Bowersox, P.l.l.c.

20080138888 - Fermenter comprising an agitator: A plug-flow operated, horizontal fermenter for anaerobic fermentation of biogenic waste includes a fermenter tank having an inlet and an outlet that is configured to be filled with a biomass material. The fermenter also includes an agitator having a shaft passing through the fermenter tank in its longitudinal direction, wherein... Agent: Ziolkowski Patent Solutions Group, Sc (zps)

20080138889 - Semiconductor device: A semiconductor device with improved convenience is provided by having an antenna for converting an electromagnetic wave into an electric signal, a detecting portion for detecting chemical reaction, and a control portion for controlling the antenna and the detecting portion. The detecting portion includes at least a detecting element, and... Agent: Eric Robinson

20080138890 - Blood analysis apparatus: The present invention provides a blood analysis apparatus which needs no mixing of multiple solutions described above, and has no deterioration of an analysis apparatus by application of a dry chemistry reagent which is good for storage, and thereby makes minimization of apparatus accomplishable, by introducing very small amount (several... Agent: Wenderoth, Lind & Ponack, L.l.p.

20080138891 - Small scale cell culture container: A bioreactor formed of a material such as glass or plastic is provided having a first closed wall spaced apart from a second closed wall. At least a portion of the height of the first closed wall extends toward the center of the bioreactor so that gas introduced at the... Agent: Millipore Corporation

20080138892 - Hepadna virus core proteins as vaccine platforms and methods of use thereof: The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core proteins or nucleic acids for use in vaccine formulations.... Agent: Medlen & Carroll, LLP

20080138893 - Optimizing expression of active botulinumtoxin type e: Nucleic acid molecules that comprise modified open reading frames providing increased expression of the encoded active BoNT/E in a heterologous cell, expression constructs and cells comprising such nucleic acid molecules and methods useful for expressing the encoding active BoNT/E from such nucleic acid molecules, expression constructs and cells.... Agent: Allergan, Inc.

20080138894 - Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use: The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried... Agent: Nixon & Vanderhye, Pc

20080138895 - Cultures of gfap+ nestin+ cells that differentiate to neurons: Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. The cells can be proliferated in adherent or suspension cultures.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c Attn: Patent Intake Customer No. 30623

20080138897 - Method for preventing hiv-1 infection of cd4+ cells: This invention provides methods for inhibiting fusion of HIV-1 to CD4+ cells which comprise contacting CD4+ cells with a non-chemokine agent capable of binding to a chemokine receptor in an amount and under conditions such that fusion of HIV-1 to the CD4+ cells is inhibited. This invention also provides methods... Agent: John P. White Cooper & Dunham LLP

20080138898 - Methods for improving antibody production: The present invention encompasses manufacturing of antibody variants, such as variant of huC242, or fragments thereof, wherein the variants are manufactured by substituting one or more amino acid residues in a parent antibody. Such substitution(s) is preferably done in a variable region framework sequence of the parent antibody comprising a... Agent: Sughrue Mion, Pllc

20080138896 - Methods for inhibiting melanocyte stem cell loss: The invention relates to methods and compositions useful for altering and assessing melanocyte stem cell self-maintenance. Loss of such self-maintenance results in loss of melanocyte stem cells and loss of natural pigmentation of hair (e.g., graying hair). Methods for identifying candidate agents to inhibit melanocyte stem cell loss and to... Agent: Wolf Greenfield & Sacks, P.c.

20080138899 - Rg1 antibodies and uses thereof: The present invention relates to antibodies, and antigen-binding antibody fragments, directed against an RG1 polypeptide. The invention further relates to methods for utilizing the antibodies, and antibody fragments, for diagnostic and therapeutic applications.... Agent: Mandel & Adriano

20080138900 - Cellular tissue microchip and method of forming cellular tissue: e

20080138902 - Method of expressing recombinant protein in cho cells: Method of expressing recombinant protein in CHO cells, by using an expression vector comprising the murine IgG 2A gene locus.... Agent: Nixon & Vanderhye, Pc

20080138901 - Packaging systems for human recombinant adenovirus to be used in gene therapy: Presented are ways to address the problem of replication-competent adenovirus in adenoviral production for use with, for example, gene therapy. Packaging cells having no overlapping sequences with a selected vector are suited for large scale production of recombinant adenoviruses. A described system produces replication-defective adenovirus. The system includes a primary... Agent: Trask Britt

20080138903 - Regulating metabolism by modifying the level of trehalose-6-phosphate: Method for the inhibition of carbon flow in the glycolytic direction in a cell by increasing the intracellular availability of trehalose-6-phosphate.... Agent: Syngenta Biotechnology, Inc. Patent Department

20080138904 - Method of breeding cells to improve tolerance to short chain fatty acids: The present invention provides a method of breeding cells to improve tolerance to a short chain fatty acid, wherein a gene encoding a protein having a function of transporting a short chain fatty acid from the inside of cells to the outside of cells, is transformed into and expressed in... Agent: Antonelli, Terry, Stout & Kraus, LLP

20080138905 - Method of inducing homologous recombination: The present invention provides a novel method of significantly promoting the ratio of homologous recombination in desirable cells. In order to enhance the ratio of homologous recombination in desirable cells such as eukaryotic cells, mutation is introduced into genes encoding factors necessary for non-homologous recombination, such as KU70 or KU80,... Agent: Pearne & Gordon LLP

20080131867 - Method for determining the effectiveness of a treatment for preeclampsia: A method for determining the effectiveness of a treatment for preeclampsia of a pregnant woman at risk for preeclampsia, the method comprising: (a) determining a first concentration of placental protein 13 (PP13) in a bodily substance of the woman obtained prior to the treatment; (b) determining a second concentration of... Agent: Nath & Associates

20080131868 - Buffy coat separator float system and method: A tube and float system for use in separation and axial expansion of the buffy coat includes a transparent or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells and plasma. The float includes a main body portion of reduced... Agent: Fay Sharpe LLP

20080131871 - Compositions and methods for identifying antigens which elicit an immune response: This invention relates to an expression vector wherein said expression vector comprises a polynucleotide promoter sequence, a polynucleotide encoding a signal sequence, a polynucleotide encoding an antigen protein or peptide, a polynucleotide encoding a cell binding element, and a polynucleotide polyadenylation sequence all operatively linked. More particularly, it relates to... Agent: Morgan Lewis & Bockius LLP

20080131873 - Compositions and methods for treating hiv infection with cupredoxin and cytochrome c: The present invention relates to cupredoxin, specifically Pseudomonas aeruginosa azurin, and/or Pseudomonas aeruginosa cytochrome c551 and their use in inhibiting of viral infection, and in particular infection of mammalian cells by the Human Immunodeficiency Virus (HIV). The invention also relates to variants and derivatives of cupredoxin and cytochrome c that... Agent: Don J. Pelto Sheppard, Mullin, Richter & Hampton LLP

20080131869 - Method for detecting an analyte: The present invention discloses an improved method for detecting an analyte. The present invention may be used for sensing devices which have a higher sensitivity and which can be used to detect very low concentration of analyte. In one embodiment, the method comprises the steps of providing a substrate, said... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080131872 - Oligonucleotides and methods for detection of west nile virus: The invention provides methods of detecting West Nile virus and oligonucleotide reagents derived from a West Nile virus consensus sequence that are useful in the methods of the invention.... Agent: Connolly Bove Lodge & Hutz, LLP

20080131870 - T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection: The present invention relates to systems, methods and kits for low-level detection of nucleic acids, detecting at least two different viral sequences in a single reaction vessel, and increasing the dynamic range of detection of a viral target nucleic acid in a sample. The present invention also relates to T-structure... Agent: Casimir Jones, S.c.

20080131892 - Affinity-shifted probes for quantifying analyte polynucleotides: Compositions, methods and devices for detecting and quantifying levels of an analyte polynucleotide in homogeneous assays using collections of soluble or immobilized hybridization probes. In certain preferred embodiments, the probes are immobilized in an array format. Polynucleotides may be quantified directly, or amplified in an in vitro nucleic acid amplification... Agent: Gen Probe Incorporated

20080131903 - Alleles of the gnd gene from coryneform bacteria: The invention relates to mutants and alleles of the gnd gene from coryneform bacteria coding for 6-phosphogluconate dehydrogenases which contain at position 329 or a comparable position of the amino acid sequence any amino acid other than L-valine, and to processes for the production of amino acids, preferably L-lysine and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080131891 - Biochemical reagents and their uses: A method for adding a first and a second functional nucleic acid sequence to a reaction mixture, in particular an amplification reaction mixture in a predetermined stoichiometry and/or at a predetermined point in time, said method comprising adding to the reaction mixture an oligonucleotide comprising a first and a second... Agent: Polsinelli Shalton Flanigan Suelthaus Pc

20080131885 - Biomarkers for cancer treatment: The present invention provides identification of a thirty-five gene set that predicts the anticancer activity of inhibitors of the RAF/MEK/MAPK pathway, methods of qualifying cancer status in a subject, methods of identifying an anti-tumor response in a subject, methods of monitoring the efficacy of a therapeutic drug in a subject,... Agent: Edwards Angell Palmer & Dodge LLP

20080131877 - Chd7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis: The present invention includes compositions and methods for diagnosis of polymorphisms associated with susceptibility to idiopathic scoliosis in a patient by determining the presence of a mutation in a nucleic acid sample provided from the patient for a mutation in a transcription factor binding site in one or more non-coding... Agent: Chalker Flores, LLP

20080131878 - Compositions and methods for the detection of small rna: Embodiments of the invention include methods of detecting one or more RNA by reverse transcribing one or more RNA target using one or more reverse transcription primer comprising in a 5′ to 3′ direction (i) a primer segment, (ii) a probe segment distinct from the primer segment, and (iii) a... Agent: Fullbright & Jaworski L.l.p.

20080131901 - De novo dna cytosine methyltransferase genes, polypeptides and uses thereof: De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine methyltransferase polynucleotides and polypeptides in diagnostic assays, for an in vitro DNA methylation application and therapeutic applications such as the treatment of neoplastic disorders.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080131890 - Detection of nucleic acids: The present invention relates to compositions and methods for the detection and characterization of small nucleic acid molecules (e.g., RNA (e.g., small RNAs such as micro RNAs (miRNAs) and small interfering RNAs (siRNAs)) and other short nucleic acid molecules). More particularly, the present invention relates to methods for the detection... Agent: Medlen & Carroll, LLP

20080131879 - Detection of subjects at risk for chd by a genotype evaluation associated with serum plant sterols enabling individualized (drug) treatment on demand: The present invention provides the use of at least one genotype selected from the group consisting of ABCG8 T400K an ABCG8 D19H as a diagnostic tool for the detection of an increased risk for coronary events in all individual based oil all elevated sitosterol concentration in a blood sample from... Agent: Kalow & Springut LLP

20080131894 - Enzymatic methods for genotyping on arrays: The invention relates to methods for enzymatic, genotyping of polymorphisms on solid supports. In some aspects the methods include ligation of allele or base specific interrogation probes to an array probe. The array probe is labeled by ligation of the interrogation probe. Ligation is dependent on the identity of the... Agent: Affymetrix, Inc Attn: Chief Ip Counsel, Legal Dept.

20080131887 - Genetic analysis systems and methods: The present invention provides methods of assessing an individual's genotype correlations by analyzing the individual's genomic profile to a database of medically relevant genetic variations that have been established to correlate to a phenotype.... Agent: Wilson Sonsini Goodrich & Rosati

20080131883 - Homogeneous analyte detection: The present invention provides novel binding pair compositions of defined and limited stability comprising nucleic acid detection markers useful for the homogeneous, sensitive detection of analytes. Also provided are methods for the sensitive homogeneous detection of analytes, particularly analytes of clinical relevance. Kits for preparing binding pairs of the invention... Agent: Paul, Hastings, Janofsky & Walker LLP

20080131881 - Markers for brain damage: Methods to identify markers for brain damage using fresh brain tissue and methods and compositions for detecting these markers are disclosed.... Agent: Morrison & Foerster LLP

20080131895 - Massive parallel method for decoding dna and rna: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise... Agent: John P. White Cooper & Dunham LLP

20080131874 - Method for efficient post-transcriptional gene silencing using intrinsic direct repeat sequences and utilization thereof in functional genomics: It is well documented that transgenes with inverted repeats can efficiently trigger post-transcriptional gene silencing (PTGS), presumably via a double stranded RNA induced by complementary sequences in their transcripts. We show here that transgenes with intrinsic direct repeats can also induce PTGS at a very high frequency (80-100%). A transgene... Agent: Suiter Swantz Pc Llo

20080131898 - Method for measuring biological sample and measuring apparatus therefor: The present invention relates to a method for measuring a biological sample and a measuring apparatus therefor and in particular to a method for measuring a biological sample in which hematopoietic progenitor cells can be counted highly accurately by distinguishing them from other hemocytes and a measuring apparatus therefor.... Agent: Sughrue Mion, Pllc

20080131886 - Method for rapid amplification of dna: The present disclosure relates to methods of DNA amplification with a first primer that has a random sequence of nucleotides at its 3′ end and a generic sequence 5′ of the random nucleotides, as well as a second primer with the generic sequence of the first primer. The disclosure further... Agent: Invitrogen Corporation C/o Intellevate

20080131897 - Methods for multiplexing amplification reactions: A two-step multiplex amplification reaction includes a first step which truncates the standard initial multiplex amplification round to “boost” the sample copy number by only a 100-1000 fold increase in the target. Following the first step the product is divided into optimized secondary single amplification reactions, each containing one of... Agent: Hogan & Hartson LLP

20080131896 - Methods of transforming plants and identifying parental origin of a chromosome in those plants: Methods for plant transformation, for improving transformation efficiency, and for producing transgenic plants are provided. The methods comprise crossing a recipient plant from a genetic line of a plant species of interest with a donor plant selected from a transformation competent genetic line of the same plant species or of... Agent: Pioneer Hi-bred International, Inc.

20080131905 - Multiparameter analysis for drug response and related methods: The invention provides a method of determining a comparative expression profile in an individual by comparing the expression levels of a sample of molecules in a population of molecules in a specimen from the individual with a health-associated reference expression region of the sample of molecules, wherein expression levels within... Agent: Mcdermott, Will & Emery

20080131875 - Multiplex assays: The present invention relates to compositions and methods for the detection and characterization of nucleic acid molecules. More particularly, the present invention relates to methods and compositions employing non cross-hybridizing and minimally cross-hybridizing tags on the 5′ ends of invasive cleavage probes.... Agent: Casimir Jones, S.c.

20080131889 - Novel human genes and gene expression products: ii: This invention relates to novel human genes, to proteins expressed by the genes, and to variants of the proteins. The invention also relates to diagnostic assays and therapeutic agents related to the genes and proteins, including probes, antisense constructs, and antibodies. The subject nucleic acids have been found to be... Agent: Edwards Angell Palmer & Dodge LLP

20080131899 - Nucleic acid amplification method: A nucleic acid amplification method, and probes for use within the method are described.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080131888 - Nucleic acid variants in the ficolin genes associated with altered innate immunity: The present invention relates to a method and kit for identifying a subject at risk of, or having, an indication associated with altered innate immunity. The present invention is based on the determination of ficolin genotypes and/or serum levels.... Agent: Howrey LLP

20080131902 - Personalized skin care composition and method for production thereof: A method for providing a personalized skin-care composition for an individual includes sampling the skin of an individual for whom a personalized skin-care composition is to be provided, testing for a predetermined set of biomarkers so as to produce an individual biomarker profile, analyzing the biomarker profile using a biomarker... Agent: Bacon & Thomas, Pllc

20080131880 - Pna-dna oligomers and methods of use thereof: Peptide nucleic acid (PNA)-deoxyribonucleic acid (DNA) oligomers and methods of using the PNA-DNA oligomers to detect and/or amplify a target nucleic acid in a sample are provided. The PNA-DNA oligomers of the invention are relatively insensitive to ionic concentration and many inhibitory proteins and, consequently, are particularly advantageous for direct... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20080131893 - Predicting parkinson's disease: This document relates to methods and materials involved in predicting Parkinson's disease. For example, methods for assessing the genotype of a human to determine whether or not the human has an increased susceptibility of developing Parkinson's disease are provided. In addition, diagnostic devices containing probe or primer collections designed to... Agent: Fish & Richardson P.c.

20080131882 - Procedure for structural characterization of a recombinant polylonal protein or a polyclonal cell line: The present invention provides a structural characterization platform that can be used to assess the stability of a polyclonal cell line during production, as well as batch-to-batch consistency of the final polyclonal products. The structural characterization platform is based on genetic analyses as well as protein characterization techniques that alone... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080131906 - Quantum dot-encoded bead set for calibration and quantification of multiplexed assays, and methods for their use: Control beads are disclosed that allow for improved quantitation of analytes in multiplexed bead assays. The control beads have a range of concentrations of calibration moieties that provide for the preparation of a titration curve. The titration curve can be used to quantify the concentration of the analytes. The titration... Agent: Invitrogen Corporation C/o Intellevate

20080131876 - Sample processing for nucleic acid amplification: Methods are described for the processing of biological samples for direct use in nucleic acid amplification without extracting or isolating the nucleic acids from the sample. In preferred embodiments, the processed sample provides the nucleic acid template in PCR-based assays.... Agent: Foley & Lardner LLP

20080131904 - Sequencing by incorporation: Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking groups include phosphate groups and carbamate groups. Fluorescent nucleotides are used to perform sequencing by synthesis with detection by... Agent: Caliper Life Sciences, Inc.

20080131884 - Tubulin mutation diagnostic: The present invention relates to methods for determining the potential of a subject to respond to a particular therapeutic agent, by determining the presence of one or more nucleotide or amino acid variants in the β-tubulin gene or protein. Also provided are methods for treating subjects whose potential to respond... Agent: Novartis Corporate Intellectual Property

20080131900 - Variants of alpha-fetoprotein coding and expression sequences: The invention discloses the sequences of variant forms of alpha-fetoprotein transcripts that have been identified in human hemopoietic progenitors but not in differentiated mature cells. The variant forms of AFP (vAFP) cDNA sequences isolated from a multipotent hemopoietic cell line, K562, differ from the authentic AFP transcript, consisting of 15... Agent: Foley And Lardner LLP Suite 500

20080131907 - Assays for detecting native-state proteins and identifying compounds that modulate the stability of native-state proteins: This invention relates to assays for detecting native-state proteins and to screening methods to identify compounds that modulate the stability of the native-state of proteins. Compounds identified by such screens can be used to treat diseases associated with protein misfolding, such as Alzheimer's Disease, familial amyloidotic polyneuropathies, and lysosomal storage... Agent: Fish & Richardson Pc

20080131909 - Ion-selective quantum dots: The invention provides ion-selective sensors comprising quantum dots capable of selectively measuring ions, e.g., Na+, K+, Cl−, etc., in various environments, including in the cytosol of a living cell. Quantum dots are attractive probes for microscopy due to their photophysical advantages over fluorescent dyes, including prolonged photostability, brightness and quantum... Agent: Ropes & Gray LLP

20080131911 - Method for quantitatively determining ldl cholesterols: A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene tribenzylphenyl ethers and a cholesterol-assaying enzyme reagent so as to preferentially react cholesterols in high density- and very low density-cholesterols among lipoproteins, and subsequently determining the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080131908 - Novel anti-notch3 antibodies and their use in the detection and diagnosis of disease: The present invention relates to novel antibodies that bind specifically to human Notch 3 and their use in the detection and/or diagnosis of Notch 3 related diseases, such as cancer. The present invention also includes nucleic acids encoding these novel antibodies, vectors and cell lines harboring the nucleic acids, and... Agent: Genentech, Inc.

20080131910 - Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use: The invention relates to the molecule referred to as ALK-1, and its role as a type I receptor for members of the TGF-β family. The molecule has a role in the phosphorylation of Smad-5 and Smad1, which also act as activators of certain genes. Aspects of the invention relate to... Agent: Fulbright & Jaworski, LLP

20080131912 - Recombinant antibodies against hepatitis c virus and methods of obtaining and using same: Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents... Agent: Paul D. Yasger Abbott Laboratories

20080131914 - Assessing risk of cerebrovascular thrombosis by measuring c4d: The present invention provides methods for the convenient, economical and sensitive assessment of the risk of whether a person will suffer from a thrombotic stroke. The present invention also provides methods for diagnosing or monitoring cerebrovascular thrombosis in a person as well as assessing the degree of severity of a... Agent: Gwen R. Wood, Ph.d., J.d. Eckert Seamans Cherin & Mellott, Llc

20080131913 - Canine 5-hydroxytryptamine 2a and 2b receptor materials and their use: Canine 5-hydroxytryptamine 2 receptor materials are described, including polypeptides corresponding to SEQ ID NOs:8 and 10 and polynucleotides expressing them corresponding to SEQ ID NOs:7 and 9. Such materials are useful as reagents in drug screening assays to identify compounds having 5-HT2 receptor-modulating activity.... Agent: Philip S. Johnson Johnson & Johnson

20080131915 - Gpr30 estrogen receptor in breast cancers: The invention provides methods of identifying metastatic disease as well as ligands such as antibodies that bind to GPR30. These antibodies are useful in the detection or treatment of endocrine tumors.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c.

20080131917 - Products and methods for single parameter and multiparameter phenotyping of cells: A method of single parameter and multiparameter characterizing of cells, particularly immunophenotyping of cells, is provided. The method preferably uses antibody coated microspheres which are adapted to bind to specific types of cells. One or more sets of coated microspheres are added simultaneously or sequentially to a suspension of cells... Agent: Pearne & Gordon LLP

20080131916 - Reagents and methods for use in cancer diagnosis, classification and therapy: Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents... Agent: Choate, Hall & Stewart LLP

20080131918 - Cholesterol assay: The present invention relates to a method of determining the concentration of cholesterol in a sample (e.g. a blood sample). The method comprising the steps of adding to the sample reagents which cause the Liebermann-Burchard (L-B) reaction; and then determining the total cholesterol concentration in the sample using fluorescence analysis.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20080131919 - Glucose level measuring method and glucose sensor utilizing glucose dehydrogenase: The present invention relates to a technique for measuring a glucose level by utilizing a reaction system containing an enzyme and an electron carrier. In accordance with the glucose level measuring method of the present invention, glucose dehydrogenase with cytochrome C attached thereto or glucose dehydrogenase derived from a microorganism... Agent: Hamre, Schumann, Mueller & Larson, P.c.

20080131922 - Cell culture detection apparatus, cell culture observation apparatus, and cell culture observation method: A cell culture detection apparatus includes a culture vessel that houses cells together with a culture liquid, a culturing device that cultures the cells under predetermined culturing conditions, a detection device that detects a feature of the cells among the cells being cultured, and a light blocking device that blocks... Agent: Scully Scott Murphy & Presser, Pc

20080131920 - Ion flux in biological processes, and methods related thereto: The present invention provides methods for promoting dedifferentiation and/or regeneration by modulating membrane potential and/or intracellular pH in non-naturally regenerating cells.... Agent: Ropes & Gray LLP

20080131921 - Neurodegenerative markers for psychiatric conditions: The present invention relates to methods for detecting a psychiatric condition optionally associated with a depression comprising the steps of measuring the concentration of at least one in vivo degradation product of tryptophan. Further, the present invention relates to the use of said values as predictive markers for the detection... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080131923 - Test unit and method for testing whether a sterilizing packaging unit is effective against recontamination, and container packaging suitable for applying said method: A testing unit and a method of testing a sterilization packaging unit for microbial contamination of sterilized objects after they have been sterilized are disclosed. The testing unit includes a dry matrix for accommodating a nutrient medium and a receptacle containing a liquid. By applying the liquid onto the matrix,... Agent: Synnestvedt & Lechner, LLP

20080131924 - Methodologies, processes and automated devices for orientation, sampling and collections of seed tissues from individual seeds: Apparatus, methods, and systems for high throughput, useful sampling of seed, wherein viability is optionally maintained, are disclosed. Seed from one generation in a plant advancement experiment is individually sampled by removal and collection of tissue from the seed. The tissue is then processed to derive one or more biochemical,... Agent: Mckee, Voorhees & Sease, P.L.C Attn: Pioneer Hi-bred

20080131925 - Production of beta-lactams in single cells: The present invention describes the transformation of a microorganism that does not naturally produce a β-lactam compound with polynucleotides involved in the biosynthesis of β-lactam compounds and the use of such transformed microorganisms in the production of β-lactam compounds or in the identification of genes or factors involved in the... Agent: Nixon & Vanderhye, Pc

20080131926 - Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and... Agent: Fitzpatrick Cella Harper & Scinto

20080131927 - Alleles of the opca gene from coryneform bacteria: The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.... Agent: Smith, Gambrell & Russell

20080131930 - Means and methods for regulating gene expression: The invention relates to means and methods for regulating gene expression and production of proteinaceous molecules. The invention provides a method for producing a proteinaceous molecule in a cell comprising selecting a cell for its suitability for producing the proteinaceous molecule, providing a nucleic acid encoding the proteinaceous molecule with... Agent: Trask Britt

20080131929 - Methods for producing mammalian cells: The invention relates to methods for producing mammalian cells having enhanced characteristics such as faster growth rates and the ability to grow to higher cell densities. The invention also relates to methods for producing cells having the ability to grow in media lacking components such as insulin and insulin substitutes.... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.

20080131931 - Mouse cytokine receptor zcytor16: Cytokines and their receptors have proven usefulness in both basic research, animal models, and as therapeutics. The present invention provides polynucleotides encoding a new cytokine receptor designated as “mouse Zcytor16”, which can bind and antagonize the IL-TIF cytokine. The present invention also provides corresponding vectors, cells, and methods of production.... Agent: Zymogenetics, Inc. Intellectual Property Department

20080131928 - Viral particle-like construct and method of forming the same under physiological conditions: There is provided a novel method of forming uniform viral particles under physiological conditions. The method of forming uniform-sized viral particle aggregates composed of viral protein is characterized by incubating a viral protein such as SV40 virus VP1 at pH 5.0 to 7.0, room temperature, in the presence of 130... Agent: Millen White Zelano Branigan Pc

20080131932 - Expression in filamentous fungi of protease inhibitors and variants thereof: Described herein are protease inhibitors, variants thereof and methods for their production.... Agent: Genencor International, Inc. Attention: Legal Department

20080131933 - Process of producing a plastid-targeted protein in plant cells: A process of producing a protein of interest in cells of a predetermined plant, comprising: introducing into said cells a vector encoding a fusion protein comprising from the N-terminus to the C-terminus (i) a transit peptide for targeting said fusion protein into plastids and, contiguous thereto, (ii) said protein of... Agent: Alston & Bird LLP

20080131934 - Process for cell culturing by continuous perfusion and alternating tangential flow: The invention relates to a process for the culturing of cells by continuous perfusion culturing of a cell culture comprising cell culture medium and cells, wherein cell culture medium is added to the cell culture, the cell culture is circulated over a filter module comprising hollow fibers resulting in an... Agent: Nixon & Vanderhye, Pc

20080131935 - Industrially useful microorganism: The present invention provides a microorganism which comprises a chromosomal DNA lacking a part or entire of the gene encoding a protein having the amino acid sequence as shown in SEQ ID NO: 1 or 2, or the gene encoding a protein having 80% or more homology with the amino... Agent: Fitzpatrick Cella Harper & Scinto

20080131937 - Conversion of target specific amplification to universal sequencing: The present teachings provide methods, compositions, and kits for amplifying nucleic acids. The amplified nucleic acids can then be sequenced. The sequencing reaction for such amplified nucleic acids can provide additional sequence information, and less redundancy, as compared to conventional approaches. In some embodiments, a target polynucleotide is amplified with... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080131939 - Simultaneous amplification and detection of ribonucleic acid be an optical method using surface plasmon resonance: Methods of performing PCR are provided. Methods may include using an optical source to provide heating for thermocyling the PCR reaction. Methods may include using surface plasmon resonance and/or fluorescence resonance enhanced transfer to allow real-time monitoring of a PCR reaction. Methods may include immobilizing a template, primer, or polymerase... Agent: Trask Britt

20080131938 - Use of predetermined nucleotides having altered base pairing characteristics in the amplification of nucleic acid molecules: The present invention provides improved methods for amplifying a nucleic acid molecule. More specifically, the invention provides methods for nucleic acid amplification which use primers having equivalent priming efficiency.... Agent: Invitrogen Corporation C/o Intellevate

20080131940 - Target cell-specific short interfering rna and methods of use thereof: The present invention provides nucleic acids that include a nucleotide sequence that encodes an siRNA, which nucleotide sequence is operably linked to a target cell-specific promoter RNA polymerase II promoter. The present invention further provides vectors, including expression vectors, which include a subject nucleic acid; and host cells that harbor... Agent: Bozicevic, Field & Francis LLP

20080131866 - Tissue preservation media: Tissue preservation media comprising a polyoxyethylene/polyoxypropylene copolymer are used to preserve tissues and organs for storage and transplantation. In particular embodiments, the polyoxyethylene/polyoxypropylene copolymer is Pluronic F68 or FLOCOR (CRL-5861; purified poloxamer 188), and the medium is Steinhardt medium, polyoxyethylene/polyoxypropylene copolymer-supplemented Optisol GS or polyoxyethylene/polyoxypropylene copolymer-supplemented ViaSpan.... Agent: Richard Aron Osman

20080131936 - Lipolytic enzyme: uses thereof in the food industry: The invention encompasses the use of a lipolytic enzyme obtainable from one of the following genera: Streptomyces, Corynebacterium and Thermobifida in various methods and uses, wherein said lipolytic enzyme is capable of hydrolysing a glycolipid or a phospholipid or transferring an acyl group from a glycolipid or phospholipids to an... Agent: Frommer Lawrence & Haug

20080131941 - Method of producing glycogen: A method of producing glycogen comprising a step of: allowing a branching enzyme having the ability to synthesize glycogen to act on a substrate in a solution to produce a glycogen, wherein the substrate is an α-glucan being linked mainly with α-1,4-glucosidic bonds and having a degree of polymerization of... Agent: Mark D. Saralino (general) Renner, Otto, Boisselle & Sklar, LLP

20080131942 - Process for modifying the genome of cornynebacteria: The invention relates to a process for producing corynebacteria comprising one or more modified genomic sequences, where a vector is used which does not replicate in corynebacteria and whose nucleic acid is not recognized by corynebacteria as foreign.... Agent: Lahive & Cockfield, LLP

20080131943 - Polynucleotides for production of farnesyl dibenzodiazepinones: This invention provides genes and their encoded proteins, involved in the biosynthesis of farnesyl dibenzodiazepinones, including ECO-04601. The invention relates to expression vectors comprising the genes and to host cells transformed with these vectors. The invention further relates to methods of producing farnesyl dibenzodiazepinone compounds using the genes and proteins... Agent: Merchant & Gould Pc

20080131944 - Process for the production of (s)-5-chloro-2-ispropylpent-4-enoic acid esters: A process for preparing a compound of formula (1) in enantiomerically enriched form, which comprises selective hydrolysis of the corresponding racemic compound (2) catalysed by an enzyme derived from a non-mammalian source and having esterase or lipase activity, wherein R is methyl or C2-10 linear or branched alkyl. The non-mammalian... Agent: The Dow Chemical Company

20080131945 - Method for producing 3-hydroxypropionaldehyde: A method for producing 3-hydroxypropionaldehyde from glycerin in high conversion ratio is provided. The method is characterized by comprising a step of dehydrating glycerin using a microbial cell and/or a treated microbial cell containing diol dehydratase and/or glycerol dehydratase, and optionally diol dehydratase reactivating factor and/or glycerol dehydratase reactivating factor,... Agent: Occhiuti Rohlicek & Tsao, LLP

20080131946 - Geraniol synthase, methods of production and uses thereof: The present invention relates to novel type of monoterpene synthase, a key enzyme in the production of the monoterpene aroma compound geraniol. More specifically, the present invention relates to nucleic acid sequences coding for CUES from flowers and herbs species, in particular sweet basil, as well as to vectors containing... Agent: Harness, Dickey & Pierce, P.L.C

20080131947 - Treatment of cellulosic material for ethanol production: The invention is directed to a process for converting cellulosic material to ethanol comprising adding an enzyme capable of releasing sugars to cellulosic material to form a cellulosic material and enzyme mixture; treating the mixture with microwave energy to enhance enzymatic digestion of the cellulosic material by the enzyme to... Agent: Faegre & Benson LLP Patent Docketing

20080131948 - Process for making isooctenes from dry 2-butanol: The present invention relates to a process for making isooctenes using dry 2-butanol derived from fermentation broth. The isooctenes so produced are useful for the production of fuel additives.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080131949 - Apparatus and method for isolating a nucleic acid from a sample: A method for preparing a nucleic acid component of a sample for amplification includes contacting the sample with a porous support that deactivates a nucleic acid amplification inhibitor component of the sample and directing a fluid through the porous support, whereby the nucleic acid component of the sample is directed... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20080131950 - Recombinant murine leukemia virus reverse transcriptases, the genes encoding and the method for expressing it: This invention provides recombinant murine leukemia virus reverse transcriptases, genes encoding these proteins and expression methods. The said murine leukemia virus reverse transcriptases are a series of MLV-RT proteins wherein the 84th amino acid residue (Q84) from the N-terminus is replaced with amino acid X, which is an amino acid... Agent: Sughrue Mion, Pllc

20080131951 - Lipolytic enzyme variants: The substrate specificity of a lipolytic enzyme can be modified by making alterations to the amino acid sequence in a defined region of the lipolytic enzyme, so as to increase the level of a desired activity or to decrease the level of an undesired activity. Thus, the inventors have developed... Agent: Novozymes North America, Inc.

20080131952 - Labeled nucleotides and nucleosides and methods for their use in dna sequencing: Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3′-OH group is derivatized at the nucleobase to include a fluorescent dye attached via a linker... Agent: Fulbright & Jaworski, LLP

20080131953 - Bacterial treatment: An isolated Bacillus strain for suppressing the growth of a fungus.... Agent: Stinson Morrison Hecker LLP Attn: Patent Group

20080131954 - Method of separating target dna from mixed dna: The present invention relates to methods of separating target DNA from mixed DNA in a sample. In some embodiments, the target DNA may be viral DNA, prokaryotic DNA, fungal DNA or combinations thereof. In some embodiments the mixed DNA includes target DNA and non-target DNA.... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080131955 - Method of separating target dna from mixed dna: The present invention relates to methods of separating target DNA from mixed DNA in a sample. In some embodiments, the target DNA is present in target organisms. In other embodiments, the target organisms may be viruses, bacteria, fungi or combinations thereof. In some embodiments the sample contains cells having nuclei.... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080131956 - Natural convection-driven pcr apparatus and method using disposable polymer chip: Provided is a natural convection-driven polymerase chain reaction (PCR) apparatus and method, which can periodically change temperature of a sample to make a natural convection-driven flow in a loop-shaped channel on a disposable polymer chip and contacting heating metal members maintained at different temperatures with channels. The natural convection-driven PCR... Agent: Rabin & Berdo, Pc

20080131957 - Disposable spinner flask: The present invention relates generally to a cell culture stirring vessel and associated impeller. More particularly, it relates to a fully integrated, disposable spinner flask vessel having a suspended impeller assembly permanently integrated therein. The invention is particularly suitable for use in applications where cells are suspended within a liquid... Agent: Corning Incorporated

20080131958 - Energy production with hyperthermophilic organisms: The present invention relates to the field of degradation with hyperthermophilic organisms, and in particular to the use of hyperthermophilic degradation to produce heat from a biomass. In some embodiments, a biomass is fermented in the presence of hyperthermophilic organisms to produce heat. The heat is used to heat a... Agent: Medlen & Carroll, LLP

20080131959 - Bioreactor construction: A bioreactor formed of a flexible material is provided having a constant aspect ratio and an adjustable length.... Agent: Millipore Corporation

20080131960 - Self standing bioreactor construction: A bioreactor formed of a flexible material is provided having a constant aspect ratio and an adjustable length. The bioreactor is rendered self standing by a support means secured to the bioreactor.... Agent: Millipore Corporation

20080131961 - Biological apparatus: An apparatus for processing biological materials, the apparatus comprising a plurality of stacked, rotatable platforms, each platform having a plurality of sample receiving areas located thereon. The apparatus has a first dispensing member mounted for dispensing reagent and/or a sample to a sample receiving area on a first stacked platform... Agent: Champions Business Park

20080131962 - Engineered cleavage half-domains: Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence.... Agent: Robins & Pasternak

20080131963 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20080131964 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20080131965 - Preform produced by electrospinning, method for producing the same and use of such a preform: The invention relates to a method for producing a preform by means of an electrospinning process. The present invention also relates to the use of the present preform as a substrate for growing human or animal tissue thereon. The present invention furthermore relates to a method for growing human or... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080131966 - Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells: A method of manufacturing a tissue matrix for implantation into a patient is disclosed. The method sets forth collecting embryonic stem cells from a placenta which has been treated to remove residual cord blood and seeding the collected stem cells onto or into a tissue matrix. The seeded tissue matrix... Agent: Jones Day

20080131967 - Keratinocytes useful for the treatment of wounds: The invention relates to new keratinocytes which may be cultured in vitro and the advantageous use thereof for preparing a product which can be used to treat acute and chronic wounds.... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20080131968 - Near-infrared electromagnetic modification of cellular steady-state membrane potentials: Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (ΔΨ-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ΔΨ of the irradiated... Agent: Mcdermott Will & Emery LLP

20080131969 - Neomycin-phosphotransferase-genes and methods for the selection of recombinant cells producing high levels of a desired gene product: The invention relates to modified neomycin phosphotransferase genes and their use in a selection method for high-producing recombinant cells. The invention further relates to expression vectors which contain a modified neomycin phosphotransferase gene and a gene of interest functionally linked to a heterologous promoter and a method of preparing heterologous... Agent: Michael P. Morris Boehringer Ingelheim Corporation