Chemistry: molecular biology and microbiology inventions 05/08

20080124701 - Growth of neural precursor cells using umbilical cord blood serum and a process for the preparation for therapeutic purposes: This invention is concerned with stem cells derived from umbilical cord blood serum and a method for growing human embryonic stem cells and adult cells comprising sera separated from clotted umbilical cord blood, including growing and differentiating cord blood stem cells into neural precursors, comprising transdifferentiating CD34+, CD45= and CD133+... Agent: Lackenbach Siegel, LLP

20080124700 - Method and apparatus for controlling the flow rate of washing solution during the washing step in a blood centrifugation bowl: A method of washing blood mixed with undesirable elements not normally found in healthy whole blood to remove the undesirable elements, the method comprising: separating the blood into components according to relative densities of the components with a rotating centrifuge bowl; providing a port through which fluid exits the bowl,... Agent: Popovich, Wiles & O'connell, PA 650 Third Avenue South

20080124702 - Methods of diagnosing cervical cancer: The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus... Agent: Wilson Sonsini Goodrich & Rosati

20080124704 - Reagent for measuring clotting time and method for manufacturing the reagent: e

20080124703 - Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents: The present invention provides methods of multi-dimensional profiling of biologically active agents and determining their effects on biological systems. The methods of the present invention include real-time impedance monitoring of cellular responses to biologically active agents and categorization of cellular kinetic profiles into mechanism specific cellular response profile groups. The... Agent: David R Preston & Associates Apc

20080124712 - Alpha globin gene dosage assay: The methods, compositions and kits disclosed herein relate generally to the detection of nucleic acids and nucleic acid mutations, such as mutations that may be correlated with disease. More specifically, the methods, compositions and kits relate to the detection of mutations in the α-globin gene cluster, to determining the gene... Agent: Richard J. Warburg Foley & Lardner LLP

20080124721 - Analysis of rare cell-enriched samples: The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g., epithelial cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject by analyzing a cellular sample from... Agent: Wilson Sonsini Goodrich & Rosati

20080124726 - Biochemical analysis of partitioned cells: The invention relates to compositions and methods for the analysis of biomolecules associated with cells, where the presence or absence of a particular biomolecule (e.g., an expressed protein or a nucleic acid gene expression product) associated with the cells is examined. The invention provides methods for single cell biochemical analysis,... Agent: Quine Intellectual Property Law Group, P.C.

20080124713 - Cleavage of rna at redundant sites: The invention relates to methods for treating samples of RNA. In an embodiment the method includes contacting the sample of RNA with a set of oligodeoxynucleotides to provide a DNA/RNA duplex. The method includes contacting the DNA/RNA duplex with an enzyme having a DNA:RNA nuclease activity to provide a digested... Agent: Agilent Technologies Inc.

20080124723 - Combined thermal devices for thermal cycling: The invention relates to systems and methods including a combination of thermal generating device technologies to achieve more efficiency and accuracy in PCR temperature cycling of nucleic samples undergoing amplification.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080124722 - Cooling in a thermal cycler using heat pipes: A device for amplifying a nucleic acid sample may include a sample holder configured to receive a nucleic acid sample, a heating system configured to raise the temperature of the sample, a cooling system configured to lower the temperature of the sample, and a controller configured to operably control the... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080124724 - Cotton event pv-ghbk04 (531) and compositions and methods for detection thereof: The present invention provides assays for detecting the presence of the 531 cotton event nucleic acid sequences in a biological sample based on the DNA sequence of the recombinant construct inserted into the cotton genome and of genomic sequences flanking the insertion site in a cotton genome.... Agent: Howrey LLP

20080124736 - Detection of virulence markers of staphylococci: Methods, kits and compositions are provided for detection of virulence markers in pathogenic organisms. More specifically, methods, kits, arrays, and compositions are described which enable detection of marker genes useful in classifying Staphylococcus species, particularly Staphylococcus aureus. Compositions of probes targeted against virulence genes encoding Panton-Valentine leukocidin (PVL), Toxic shock... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080124710 - Devices for generating detectable polymers: This document provides systems, devices, and methods involved in generating detectable polymers. For example, diagnostic systems, diagnostic devices, primer systems, and collections of primer systems are provided.... Agent: Fish & Richardson P.C.

20080124705 - Homogeneous multiplex screening assays and kits: Highly multiplexed homogeneous in vitro screening assays for numerous possible nucleic acid targets, any of which might be present in a sample, utilize fluorescent hybridization probes that are combinatorially coded from a panel of fluorophores by subdividing each probe into portions and differently labeling each portion such that, when portions... Agent: Fish & Richardson P.C.

20080124708 - Labeled nucleotide composition: Embodiments of labeled nucleotide compositions are described. Methods are described in which a sample containing RNA is contacted with an enzyme having an RNA ligation activity in the presence of a labeled nucleotide composition to provide labeled RNA. Methods of performing an array analysis of a labeled RNA sample are... Agent: Agilent Technologies Inc.

20080124717 - Method and apparatus for label-free electronic real-time double-stranded nucleic acid detection: In various embodiments, the present invention is a method and apparatus for label-free detection and optional quantification of double-stranded nucleic acid comprising binding a first layer comprising a charged species to a sensing surface having an associated first charge, wherein the first layer confers to the sensing surface a second... Agent: Choate, Hall & Stewart LLP

20080124716 - Method and device for time-effective biomolecule detection: Rapid detection of biomolecules in samples involving biochemical amplification of the target biomolecule is achieved by collecting or separating aliquots of the amplification reaction mixture prior to completion of amplification and assaying these samples as they are collected.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080124735 - Method for detection of one or more cpg positions: The invention relates generally to novel and substantially improved methods for detecting CpG positions. Particular aspects relate to a method for detection of one or more CpG positions. Said method comprises: providing a sample, binding a protein or peptide onto the DNA of said sample, hybridizing a probe onto the... Agent: Kriegsman & Kriegsman

20080124732 - Method for optical measurement of multi-stranded nucleic acid: e

20080124715 - Method for rapid identification of porcine insulin-like growth factor 2 intron 7 point mutation: A method for rapidly identifying a point mutation in porcine insulin-like-growth factor 2 intron 7 uses published primers to amplify the target DNA fragments by polymerase chain reaction. The DNA fragments are cloned and sequenced for confirmation and method validation. The key positions of the sequence are modified to generate... Agent: Rosenberg, Klein & Lee

20080124714 - Method for stabilizing biological samples for nucleic acid analysis: Disclosed is a method for preparing nucleic acid containing biological samples for a nucleic acid integrity assay and/or multiple mutation analysis by incubating the biological sample with a stabilization solution that includes a buffer, a chelating agent and a salt.... Agent: Goodwin Procter LLP Patent Administrator

20080124720 - Method of sample analysis and apparatus therefor: A method and apparatus for processing and analysing samples. The invention can be used in relation to any sample analysis where processing of the sample with one or more reagents is required. The invention has particular relevance for the DNA analysis of biological materials. The method includes introducing the sample... Agent: Foley & Lardner LLP

20080124727 - Methods for rapidly transforming monocots: The present invention provides methods for transforming monocot plants via a simple and rapid protocol, to obtain regenerated plants capable of being planted to soil in as little as 4-8 weeks. Associated cell culture media and growth conditions are also provided, as well as plants and plant parts obtained by... Agent: Sonnenschein Nath & Rosenthal LLP

20080124718 - Methods of diagnosing, predicting therapeutic efficacy and screening for new therapeutic agents for leukemia: The invention discloses methods for leukemia diagnosis and determining the effectiveness of certain therapies. The methods of the present invention also encompass a way to predict a subject's responsiveness to therapeutic interventions for leukemia, as well as to monitor relapse during treatment due to therapeutic resistance. Further, the methods disclosed... Agent: Panacea Pharmaceuticals, Inc.

20080124737 - Microrna1 therapies: Delta protein expression in a cell is reduced by introducing miR-1 into the cell, and detecting a reduction of Delta protein expression in the cell.... Agent: Richard Aron Osman

20080124730 - Modified sirna constructs for detecting riscs: The present teachings provide novel methods, compositions, and kits for detecting siRNA-containing RISCs. In some embodiments, modified siRNA constructs are employed that contain an anti-sense strand and a sense strand, wherein the anti-sense strand comprises a 3′ end, wherein the 3′ end comprises a fluorophore, and wherein the sense strand... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080124731 - Natural food tracer: The present invention relates to tracers for foods comprising natural nucleotide sequences, methods for the production thereof, uses of said tracers and food products labeled with said tracers.... Agent: Nixon & Vanderhye, PC

20080124707 - Nucleic acid concatenation: The present invention provides a method of manipulating nucleic acids. In particular, of length-controlled concatenating of nucleotide fragments, the method comprising: (a) providing at least two nucleotide fragments, wherein each fragment has one ligatable end and one non-ligatable end; and (b) allowing the two fragments to ligate at the ligatable... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080124729 - Nucleic acid mutation detection by analysis of saliva: Methods for detection of a cell proliferative disorder, such as cancer, are provided utilizing analysis of target mutant nucleic acids in saliva specimens are described. The presence of target mutant nucleic acids is indicative of a neoplastic disorder of the lung or the head and neck.... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP

20080124706 - Nucleic acid probe, nucleic acid chip, method for detecting target nucleic acid, method for screening drug, apparatus for detecting target nucleic acid, and, gene diagnosis method: The nucleic acid probe of the invention is a nucleic acid probe for detecting a trace amount of target nucleic acid highly sensitively, highly accurately, and highly quickly, and is designed so that the nucleic acid probe undergoes a conformational change after hybridization to the target nucleic acid and that... Agent: Kratz, Quintos & Hanson, LLP

20080124709 - Nucleic acid size detection method: The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an optional second fragmentation, and identification using a marker sequence. In particular aspects, an expansion or reduction of tandem repeat sequences... Agent: Foley & Lardner LLP

20080124719 - Patterned spot microarray using photocatalyst and method of manufacturing the same: Provided is a method of preparing a patterned spot microarray using a photocatalyst. The method comprises coating the photocatalyst on a substrate to form a photocatalyst layer, coating a composition comprising a functional group to be connected to a biomolecule on the photocatalyst layer to form an organic layer, spotting... Agent: Cantor Colburn, LLP

20080124733 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 90 to 91 and complementary or modified sequences thereof or a... Agent: Fitzpatrick Cella Harper & Scinto

20080124711 - Protocol for detecting proteins in a culture containing an embryo: The present invention provides methods to determine the sex of an embryo by detecting the presence of a protein associated with the Y chromosome in a sample of culture medium obtained by sampling a culture medium containing the embryo. The present invention further provides methods to identify a protein associated... Agent: Darby & Darby P.C.

20080124728 - Removal of molecular assay interferences for nucleic acids employing buffered solutions of chaotropes: The present disclosure relates to methods, compositions, and systems for reducing and/or eliminating (“suppressing”) undesirable effects of a masking agent on a molecular assay. In addition, the present disclosure relates to molecular assays of nucleic acids in bodily fluids and/or excretions. Suppressing undesirable effects of a masking agent may include,... Agent: Baker Botts L.L.P. 1500 San Jacinto Plaza

20080124734 - Stable cell lines and methods for evaluating gastrointestinal absorption of chemicals: Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines comprising such nucleic acids and vectors. Methods for screening chemicals and biomolecules for gastrointestinal absorption in animals, and kits for practicing... Agent: Woodcock Washburn LLP

20080124725 - Tagged microorganisms and methods of tagging: The present invention provides methods for tagging and/or identifying microorganisms. In some preferred embodiments, the microorganisms are bacteria. In some particularly preferred embodiments, the bacteria are members of the genus Streptococcus, while in other embodiments, the bacteria are members of other genera. The present invention also provides microorganisms tagged using... Agent: Kamrin T. Macknight Danisco US Inc., Genencor Division

20080124739 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Heller Ehrman LLP

20080124738 - Compositions and methods of testing for tuberculosis and mycobacterium infection: The present disclosure concerns methods, compositions and apparatus for detecting pathogens and/or molecular markers. In a particular embodiment, the pathogen to be detected may be Mycobacterium bovis or any other Mycobacterium species that causes tuberculosis in a mammal. However, the disclosed methods are not limited and virtually any type of... Agent: Faegre & Benson LLP Patent Docketing

20080124741 - Canine cholecystokinin 1 receptor materials and their use: Canine CCK1 receptor materials are described, such as polypeptides having amino acid sequences corresponding to SEQ ID Nos.: 14, 15, and 16 or functional variants thereof and polynucleotides expressing them having nucleic acid sequences corresponding to SEQ ID Nos.: 11, 12, and 13 or complements thereof. Such materials are useful... Agent: Philip S. Johnson Johnson & Johnson

20080124743 - Diagnostics and therapeutics for diseases associated with neuromedin u1 receptor (u1): The invention provides a human NMU1 which is associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, inflammation diseases, cancer diseases, and disorders of the liver. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological... Agent: Banner & Witcoff, Ltd.

20080124742 - Modulators of odorant receptors: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and... Agent: Medlen & Carroll, LLP

20080124744 - Antibodies that specifically bind pms2: Antibodies against PMS2 and PMS2-134 and cells that produce the anti-PMS2 and anti-PMS2-134 antibodies are provided. The antibodies of the invention may be used in methods for detecting a PMS2 protein, including a truncated PMS2, and in methods for detecting an abnormal condition in a patient.... Agent: Woodcock Washburn LLP

20080124745 - Method and device for characterizing cellular components of a biological fluid: The invention concerns a method for differentiating and counting cellular components present in a biological fluid sample comprising a primary cytological analysis step typically implemented by a flow cytometry equipment (1) to obtain a set of primary results enabling the set of cellular components of the sample to be differentiated... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080124746 - Methods and compositions relating to anthrax pathogenesis: The structures of Edema Factor alone and Edema Factor bound to calmodulin without substrate has been crystallized and its structure determined by x-ray crystallography. Based upon these crystal structures, a method assaying for inhibitors of infection by a bacteria is presented which comprises obtaining a potential inhibitor, obtaining a calmodulin... Agent: Fulbright & Jaworski L.L.P.

20080124747 - Methods for detecting b. anthracis infection: This invention pertains to methods for detecting B. anthracis and antibodies to B. anthracis, the causative agent of anthrax, in a subject... Agent: Townsend And Townsend And Crew, LLP

20080124740 - Three dimensional coordinates of hypoxia inducible factor 1 alpha (hif-1 alpha)-prolyl hydroxylase (egln1) and uses thereof: The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate EGLN1 prolyl hydroxylase and thereby regulate HIF-regulated disorders.... Agent: Needle & Rosenberg, P.C.

20080124748 - Method of quantifying cholesterol in high density lipoprotein and reagent compositions: A method for specifically quantifying HDL cholesterol in which cholesterol in lipoproteins other than HDL is erased in the first step, and HDL cholesterol is specifically quantified in the second step, by which accurate values can be obtained even in measurements of abnormal samples such as disorder of lipid metabolism... Agent: Birch Stewart Kolasch & Birch

20080124749 - Device and method for measuring properties of a sample: Test strips designed to prevent or reduce false results when measuring the condition of a sample are provided. The test strips can be used for analysis of samples by methods including electrical and optical measurements. The reagent test strips and methods are particularly suited for use in the detection of... Agent: Wilson Sonsini Goodrich & Rosati

20080124750 - Method for determining the efficacy of an anthracycline anticancer agent and a device therefor: The present invention provides a method for determining susceptibility to an anthracycline anticancer agent, comprising the steps consisting of detecting the expression of activated Akt in a cancer cell or cancer tissue and determining the susceptibility of the cancer cell or cancer tissue to the anthracycline anticancer agent on the... Agent: Sughrue Mion, PLLC

20080124752 - Biomarkers related to metabolic age and methods using the same: Biomarkers relating to metabolic age are provided, as well as methods for using such biomarkers as biomarkers for determining metabolic age. In addition, methods for modulating the metabolic age of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for metabolic age.... Agent: Hutchison Law Group PLLC

20080124751 - Combinatorial rosamine library and uses thereof: o

20080124753 - Spicematrix technology for taste compound identification: The present invention is related to a screening method to identify compounds that impact taste. Reactivity profiles of spice compounds are determined by assaying activity in test cells expressing various ion channels. The reactivity profiles can be used to identify novel taste compounds having similar taste effects.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080124754 - Rapid method of detection and enumeration of sulfide- producing bacteria in food products: A rapid method for detecting spoilage of a food sample, particularly a fish sample, by detecting and enumerating sulfide-producing bacteria (SPB). A growth medium containing iron and sulfur is combined with the food sample forming an incubation mixture which is incubated for a period of time. In one embodiment, a... Agent: Dunlap Codding & Rogers, P.C.

20080124755 - Biosynthesis of beta-cryptoxanthin in microbial hosts using an arabidopsis thaliana beta-carotene hydroxylase gene: A method is disclosed for preparing β-cryptoxanthin from a microorganism transformed with the β-carotene hydroxylase gene from Arabidopsis thaliana by culturing the transformant in a medium and recovering β-cryptoxanthin from the resultant culture. Both bacteria and yeasts were successfully transformed. Surprisingly, β-cryptoxanthin is the dominant carotenoid produced by the transformant... Agent: Davis, Brown, Koehn, Shors & Roberts, P.C. The Financial Center

20080124761 - Cell culture method and utilization of the same: It is an object of the present invention to allow a cell to produce a protein at a high level using a medium containing an enzymatic degradation product of fish meat or a fish meat extract. A method of culturing a cell comprising starting culturing in an initial medium and... Agent: Foley And Lardner LLP Suite 500

20080124763 - Constructs and methods for expression of recombinant proteins in methylotrophic yeast cells: The current invention relates to vectors and methods for efficient expression of proteins in methylotrophic yeast cells. More particularly said vectors comprise the coding sequence for a lysozyme signal peptide or a functional equivalent thereof joined to a protein. Said lysozyme signal peptide is efficiently removed when the protein comprising... Agent: Nixon & Vanderhye, PC

20080124757 - Discrete acyltransferases associated with type i polyketide synthases and methods of use: Genetic and biochemical characterization of the leinamycin biosynthesis gene cluster from Streptomyces atroolivaceus S-140 revealed two PKS genes, lnmI and lnmJ, that encode six PKS modules, none of which contains a cognate AT domain. The AT activity is provided in trans by a discrete protein, LnmG, which loads the malonyl... Agent: Quarles & Brady LLP

20080124764 - Heterologous alpha amylase expression in aspergillus: The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same.... Agent: Lynn Marcus-wyner Genencor International, Inc.

20080124756 - Light utilization alteration of photosynthetic microorganisms: Methods provided herein are directed to increasing the efficiency of light utilization of photosynthetic microorganisms. Also provided are screening assays, genetic constructs, and photosynthetic microorganisms for increasing light utilization efficiency and production of molecules such as ATP, oxygen, hydrogen, and recombinant proteins. Methods provided herein can be performed with any... Agent: Solazyme, Inc.

20080124762 - Methods and materials for expression of a recombinant protein: Recombinant expression vectors are provided comprising a 3′ UTR of a light chain and an Epstein-Barr virus origin of replication. Also provided are host cells comprising such vectors and methods of producing recombinant protein with such vectors. Additional methods of producing a recombinant protein involve contacting cells with a first... Agent: Anne Dollard Xoma (us) LLC

20080124759 - Novel fgf homolog zfgf12: The present invention relates to polynucleotide and polypeptide molecules for zFGF12 a novel member of the FGF family. The present invention also includes antibodies to the zFGF12 polypeptides, and methods of using the polynucleotides and polypeptides.... Agent: Zymogenetics, Inc. Intellectual Property Department

20080124760 - Regulatory nucleic acid elements: TE elements bring about an increase in the expression of the product gene, particularly when stably integrated in the eukaryotic genome, preferably the CHO-DG44 genome. Chromosomal positional effects are thereby overcome, shielded or cancelled out. In this way the proportion of high producers in a transfection mixture and also the... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20080124758 - Transmembrane domain removed recombinant human tyrosinase and method of producing the same: Disclosed are recombinant human tyrosinase, which the transmembrane domain of human tyrosinase is removed and a method of producing the same. The method includes expressing human tyrosinase gene, which C-terminal transmembrane domain of human tyrosinase is removed, and separating and purifying the expressed recombinant human tyrosinase. The method according to... Agent: Buchanan, Ingersoll & Rooney PC

20080124765 - Expression of functional antibody fragments: Methods for the high yield production of antibody Fv-containing polypeptides, especially Fab′ and F(ab′)2 antibody fragments are provided. Expression of heavy and light chain Fv in a microbial secretory system is followed by recovery of Fv from the periplasm under conditions that maintain a cysteine residue as a free thiol.... Agent: Genentech, Inc.

20080124766 - Scaffold material capable of inducing biological hard tissue or soft tissue: To provide an implant material which exhibits relatively high mechanical binding with an osteoblast and also high strength. [MEANS FOR SOLVING PROBLEMS] A scaffold material (10) capable of inducing a biological hard tissue, which comprises a rod (11) having a trunk portion (21) and bride girders (22), a binding layer... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080124767 - Production and secretion of sucrose in photosynthetic prokaryotes (cyanobacteria): The present invention includes compositions and methods for making and producing sucrose from cyanobacteria, by growing a cyanobacterium in a growth medium; incubating the cyanobacteria in a salt containing medium under conditions that promote sucrose production; and exposing the cyanobacteria to acidic conditions, wherein the acidic conditions trigger sucrose secretion... Agent: Chalker Flores, LLP

20080124768 - Methods and compositions for amplification of dna: Compositions for the amplification of damaged nucleic acids are disclosed. The compositions generally comprise a mesophilc polymerase, a thermostable polymerase, and an AP endonuclease. Methods of using the same for the amplification of damaged DNA are also disclosed.... Agent: Senniger Powers LLP (sgm)

20080124769 - Apparatus and method for reducing non-specific amplification in multiplex pcr: Provided are a well plate for multiplex PCR including: a plurality of wells for multiplex PCR each well comprising at least two partitioned chambers formed by at least one barrier that extends in an upward direction from the bottom of the wells and has a lower height than the height... Agent: Cantor Colburn, LLP

20080124770 - Arabinose isomerase expressed from corynebacterium genus and tagatose manufacturing method by using it: The present invention relates to a thermophilic arabinose isomerase and a method of manufacturing tagatose using the same, and more precisely, a gene encoding arabinose isomerase originating from the thermophilic Thermotoga neapolitana DSM 5068, a recombinant expression vector containing the gene, a method of preparing a food grade thermophilic arabinose... Agent: Occhiuti Rohlicek & Tsao, LLP

20080124771 - Food grade thermophilic arabinose isomerase expressed from gras, and tagatose manufacturing method by using it: The present invention relates to a thermophilic arabinose isomerase and a method of manufacturing tagatose using the same, and more precisely, a gene encoding arabinose isomerase originating from the thermophile Geobacillus stearothermophilus DSM22, a recombinant expression vector containing the gene, a method of preparing a food grade thermophilic arabinose isomerase... Agent: Occhiuti Rohlicek & Tsao, LLP

20080124772 - Plant enzymes for bioconversion: The invention provides a method for converting sesquiterpene. The method includes reacting a sesquiterpene substract with a sesquiterpene converting enzyme. The enzyme is from a species or organism containing sesquiterpenes. The sesquiterpene substrate is not naturally present in the species or organism.... Agent: Hoffmann & Baron, LLP

20080124773 - Process for producing sulfur-containing hydroxycarboxylic acid: A process for producing a sulfur-containing α-hydroxycarboxylic acid compound, which comprises a step for reacting a sulfur-containing dihydroxy compound with a cell or a material from treated cell of a microorganism that has an ability to convert the sulfur-containing dihydroxy compound to a corresponding α-hydroxycarboxylic acid compound.... Agent: Sughrue Mion, PLLC

20080124774 - Solvent tolerant microorganisms and methods of isolation: Lactobacillus bacteria having enhanced tolerance to butanols have been isolated. The bacteria are useful for the fermentive production of butanol. New methods for the isolation of butanol tolerant Lactobacillus are also provided.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080124775 - Method for increased production of biogas: c

20080124776 - Carbodithioate ligands for nanotechnology and methods of use: The present invention is directed to methods and products related to carbodithioate ligands bonded to surfaces. The invention is further directed to methods of inducing cell injury or death. Such methods may be useful in the treatment of diseases such as cancer.... Agent: Bose Mckinney & Evans LLP James Coles

20080124777 - Method for releasing genetic material from solid phase: The present invention relates to systems for releasing genetic materials from a solid medium. The present invention also relates to methods for releasing genetic materials from a solid medium. The present invention further relates to methods for isolating genetic material from a biological sample.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080124778 - Electroporation cuvette with high field intensity and field-induced agitation: An electroporation cuvette is constructed as a cylinder with a filament electrode at the cylinder axis and one or more peripheral electrodes on the internal cylinder wall. An additional cuvette design is one with a plurality of peripheral electrodes distributed at various locations around the circumference of the cuvette wall... Agent: Townsend And Townsend And Crew, LLP

20080124779 - Microfluidic magnetophoretic device and methods for usig the same: A microfluidic device may employ one or more sorting stations for separating target species from other species in a sample. The separation is driven by magnetophoresis. A sorting station generally includes separate buffer and sample streams. A magnetic field gradient applied to the sorting station deflects the flow path of... Agent: Bozicevic, Field & Francis LLP

20080124780 - Hybrid immobilized catalytic system with controlled permeability: An immobilized catalytic system comprising a carrier layer containing a catalytic entity and a permeable screening layer for providing controlled access between the immobilizing catalytic entity and the surrounding environment and methods of making such systems are disclosed. The carrier layer includes the catalytic entity mixed with a neutral or... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20080124781 - Enzymes with modified amino acids: An enzyme for protein digestion is provided, having at least one amino acid containing an N-terminal amino group and/or an amino group side chain, which is modified by a substituent introduced into the enzyme so as to reduce autodigestion and/or enhance protein digestion of the. Furthermore, a method for modification... Agent: Agilent Technologies Inc.

20080124782 - Method for producing a multifunctional enzyme: This invention relates to a multifunctional enzyme having lysyl hydroxylase and glycosyltransferase activity and to the use of the enzyme in glycosylating hydroxylysine residues. In particular this invention relates to a method for producing glycosyltransferase activity, which comprises that a nucleotide sequence encoding lysyl hydroxylase and glycosyltransferase activity is introduced... Agent: Birch Stewart Kolasch & Birch

20080124783 - Multiply-substituted protease variants: Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino... Agent: Genencor International, Inc. Attention: Legal Department

20080124784 - Novel modified s-hydroxynitrile lyase: This invention relates to S-hydroxynitrile lyase having excellent tolerance to heat, organic solvents, and the like, which is obtained by modifying at least one amino acid in the helix D3′, helix A, and β-sheet 2 domains in the amino acid sequence of wild-type S-hydroxynitrile lyase.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080124785 - Alanine 2, 3-aminomutase: Alanine 2,3-aminomutase sequences are disclosed, as are cells having alanine 2,3-aminomutase activity and methods of selecting for such cells. Methods for producing beta-alanine, pantothenate, 3-hydroxypropionic acid, as well as other organic compounds, are disclosed.... Agent: Cargill, Incorporated

20080124786 - Acyltrasferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts: Two acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, the genes encoding phophatidylcholine-diacylglycerol acyltransferase (PDAT) and diacylglycerol acyltransferase (DGAT2) have been isolated from Y. lipolytica. These genes encode enzymes that participate in the terminal... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080124787 - Microinjection devices and methods of use: The present invention provides for microinjection devices comprising a needle and a viewing instrument wherein the viewing instrument provides viewing of an object to an operator from an angle other than a right angle to the object.... Agent: Avigenics, Inc.

20080124788 - Bioassay system and bioassay method: Bioassay equipment which prevents a variation in concentration of a medium or deposition/bonding of a substance in the medium to be caused by drying of the medium being stored or held in a reaction region providing an inter-substance interaction field. The bioassay equipment (2) comprises at least a means for... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080124789 - High throughput functional genomics: This invention focuses on the marriage of solid-state electronics and neuronal function to create a new high-throughput electrophysiological assay to determine a compound's acute and chronic effect on cellular function. Electronics, surface chemistry, biotechnology, and fundamental neuroscience are integrated to provide an assay where the reporter element is an array... Agent: NeifeldIPLaw, P.C.

20080124790 - Biosensor for the detection of protein kinase a, and kit comprising the same: The present invention relates to a biosensor specifically detecting a protein kinase A (PKA), and a diagnosis kit comprising the biosensor. In particular, the present invention relates to a biosensor for detecting a PKA comprising a cantilever, and a protein kinase inhibitor (PKI) immobilized on the surface of the cantilever;... Agent: Jhk Law

20080124791 - Device and method for collecting of organic waste: A device and method for collecting organic waste is disclosed. The invention comprises a biodegradable bag that hangs inside a rigid container covered by a perforated lid. A filter lines the inside of the lid which rests on the rim of the rigid container. The biodegradable bag is secured onto... Agent: Asmish G. Airan

20080124792 - Hybrid promoters: The invention includes hybrid promoters containing an LTR component and a promoter component, transgenic avians containing the hybrid promoters in their genome and methods of making the transgenic avians.... Agent: Avigenics, Inc.

20080124793 - Membrane fusion proteins derived from reovirus: In accordance with the present invention, a family of membrane fusion protein and polynucleotides encoding the proteins have been identified. The proteins and nucleotides are derived from the family Reoviridae. Two membrane fusion proteins have been isolated from reoviruses isolated from poikilothermic hosts: the p14 protein from reptilian reovirus (RRV)... Agent: Smart & Biggar P.o. Box 2999, Station D

20080124794 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080124795 - Vascular cell culture patterning substrate: e

20080124796 - Genetic constructs having heterologous 3' polyadenylation signal sequence motifs that function in plants: The present invention relates to heterologous genes comprising non-plant 3′ termination sequences and plant expression cassettes incorporating the heterologous genes. The present invention also comprises methods for construction of the plant expression cassettes and introducing the cassettes into plant cells.... Agent: Pioneer Hi-bred International, Inc.

20080124797 - Genetic constructs having heterologous 3' polyadenylation signal sequence motifs that function in plants: The present invention relates to heterologous genes comprising non-plant 3′ termination sequences and plant expression cassettes incorporating the heterologous genes. The present invention also comprises methods for construction of the plant expression cassettes and introducing the cassettes into plant cells.... Agent: Pioneer Hi-bred International, Inc.

20080124798 - Method for manufacturing glycoproteins having human-type glycosylation: The present invention provides a method for manufacturing a glycoprotein having a human-type sugar chain comprising a step in which transformed plant cell is obtained by introducing to a plant cell the gene of glycosyltransferase and the gene of an exogenous glycoprotein, and a step in which the obtained transformed... Agent: Wolf Greenfield & Sacks, P.C.

20080124799 - Plant activation of insect toxin: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20080124800 - Arabinogalactan protein compositions and methods for fostering somatic embryogenic competence: Methods for fostering somatic embryogenic competence of a plant cell or tissue by contacting the plant cell or tissue with an arabinogalactan protein (AGP) composition effective for fostering somatic embryogenic competence in plant species and varieties that are recalcitrant to somatic embryogenesis and/or regeneration are provided. AGP compositions useful for... Agent: Greenlee Winner And Sullivan P C

20080124801 - Pluripotent cell growth media: Self renewal of pluripotent cells in culture is promoted using a serum-free medium that comprises, inter alia, insulin and progesterone and has an osmolarity of 260-270 Osm/kg.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080124803 - Cdna corresponding to the antigenome of nonsegmented negative stranded rna viruses and process for the production of such viruses: The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080124802 - Method for labeling specific cells within living cells or tissues: The present invention discloses a method for labeling specific cells within living cells or tissues. The method comprises preparing the vectors with genes of photoactivable fluorescent proteins, followed by injecting the vectors containing genes of photoactivable fluorescent proteins together with genes of other fluorescent proteins into living cells or tissues,... Agent: Birch Stewart Kolasch & Birch

20080124804 - Methods of increasing polypeptide accumulation in plants: The present invention provides methods and compositions directed to the production of polypeptides in plant protein storage tissue. Methods of the invention include methods for producing polypeptides in protein storage tissues by decreasing the level of protease activity in the plant protein storage tissue. Compositions of the invention include plants... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20080118907 - Adhesion-preventing material and process for preventing adhesion: The present invention provides (1) an adhesion-preventing material comprising a crosslinked water absorbent poly-y-glutamic acid as an effective ingredient; (2) the adhesion-preventing material described above, wherein the crosslinked water absorbent poly-y-glutamic acid is in the form of powder having a water absorption coefficient in the range of 800-2000; (3) a... Agent: Wenderoth, Lind & Ponack, L.l.p.

20080118908 - Method of selecting a sperm cell based on its dna content: The method and process for sex selection based on a quantitative DNA measurement in spermatozoa with damaged plasma membrane.... Agent: Dmitri Dozortsev

20080118909 - Methods and kits for isolating sperm cells: Disclosed are methods for isolating sperm cells from an aqueous sample and kits for isolating sperm cells from an aqueous sample.... Agent: Michael Best & Friedrich LLP

20080118910 - Control nucleic acid constructs for use with genomic arrays: In some embodiments, nucleic acid constructs are provided which comprise a nucleic acid vector having an insert comprising a control nucleic acid molecule. The control nucleic acid molecule comprises a sequence complementary to a negative control probe in a microarray. Methods and kits for using the nucleic acid constructs as... Agent: Agilent Technologies Inc.

20080118911 - Test device for the in-vitro diagnosis of multi-analyte tests and use thereof: The present invention generally relates to the diagnosis of diseases and in particular novel methods and devices for an improved use of markers that are associated with diseases to be diagnosed. The present invention can find use in particular in the fields of diagnostics, diagnostic tests, and rapid tests.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080118918 - Compositions and methods for determining and predicting treatment responses for depression and anxiety: The invention provides genetic means, including compositions (e.g., kits) and methods, to predict the efficacy of a treatment in depression and anxiety and to predict a patient's response to a particular a specific medication or treatment. The invention provides methods for diagnosing the presence of a psychiatric disorder or determining... Agent: Morrison & Foerster LLP

20080118928 - Diagnostics and therapeutics for arterial wall disruptive disorders: The invention provides diagnostics, therapeutics and drug screening assays for arterial wall disruptive disorders, based on the discovery of a high level of correlation between the incidence of arterial wall disruptive disorders and the incidence of Age Related Macular Degeneration (AMD). In one embodiment, the arterial wall disruptive disorder is... Agent: Townsend And Townsend And Crew, LLP

20080118920 - Diagnostics and therapeutics for diseases associated with an il-1 inflammatory haplotype: Methods and kits for determining whether a subject has or is predisposed to developing a disease which is associated with IL-1 polymorphisms and assays for identifying therapeutics for treating and/or preventing the development of these diseases are provided.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c.

20080118922 - Flap endonuclease mutants: A mutation is introduced into the substrate-binding site of flap endonuclease to prepare a mutant with modified substrate specificity. Using the mutant as a reagent for the analysis of genetic polymorphism, the analysis of genetic polymorphism can be performed more accurately, easily and sensitively as compared with conventional methods.... Agent: Sughrue Mion, Pllc

20080118914 - Follistatin gene as a genetic marker for first parity litter size in pigs: Disclosed herein are genetic markers for litter size in first parity gilts, methods for identifying such markers, and methods of screening pigs to determine those more or less likely to have large litters in their first parity and more or less likely to produce litters with offspring who also posses... Agent: Charlotte Dawn Blowe

20080118913 - Genetic manipulation of brain serotonin using the pet-1 transcriptional control region: Serotonin neurons modulate most homeostatic Central Nervous System (CNS) functions while influencing the expression of behavioral traits such as mood, aggression and anxiety. Serotonin neuron dysfunction has been implicated in depression, addiction, autism and sudden infant death syndrome. This disclosure describes a straightforward, highly reproducible method for genetically accessing serotonin... Agent: Raymond A. Miller Pepper Hamilton LLP

20080118917 - Isothermal snp detection method: In some embodiments, the present teachings provide a method for detecting a nucleotide of interest comprising; forming an amplification reaction mixture comprising a mismatched primer, a target polynucleotide, a strand-displacing polymerase lacking 3′ to 5′ exonuclease activity, a recombinase, and a single-stranded DNA binding protein; hybridizing a mismatched primer to... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080118923 - Method and compositions for discriminating gram-negative and gram-positive bacteria: Provided are an oligonucleotide primer set for amplifying at least one target sequence of the 16S rRNA gene in gram-negative bacteria and at least one target sequence of the 16S rRNA gene in gram-positive bacteria, a probe set specifically hybridizing with at least one target sequence of the 16S rRNA... Agent: Cantor Colburn, LLP

20080118927 - Method and kit for detection of microsatellite instability-positive cell: A method for detecting an abnormal cell based on gene expression analysis, which is useful for cancer diagnosis, is provided. A gene expression analysis method, comprising: measuring the expression level of a transcript of a human MLH1 gene containing the nucleotide sequence as shown in SEQ ID NO: 1 at... Agent: Stanley P. Fisher Reed Smith LLP

20080118926 - Method for detecting methylation in genes and method for examining neoplasm through detecting methylation in genes: An object of the present invention is to provide a method for detecting methylation in genes contained in a biological sample in a simple and economical manner. Further object of the present invention is to provide an accurate and good sensitivity examination method for a case the neoplasm is assayed... Agent: Jhk Law

20080118921 - Method for determining the amount of template nucleic acid present in a sample: A method for determining the amount of template nucleic acid present in a sample comprising the steps of: i) bringing into association with the sample all the components necessary for nucleic acid amplification, and all the components necessary for a bioluminescence assay for nucleic acid amplification and subsequently: ii) performing... Agent: Nixon & Vanderhye, Pc

20080118912 - Raman-enhancing, and non-linear optically active nano-sized optical labels and uses thereof: A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. In certain embodiments, the noble metal nanoclusters are encapsulated by a dendrimer,... Agent: Sutherland Asbill & Brennan LLP

20080118916 - Sequential analysis of biological samples: Methods for detecting multiple targets in a biological sample are provided. The methods includes contacting the sample with a first probe; physically binding the first probe to a first target; observing a first signal from the first probe; applying a chemical agent to modify the first signal; contacting the sample... Agent: General Electric Company Global Research

20080118915 - Synthesis of single-stranded dna: A method of producing single-stranded DNA. In one form, the method involves providing a uracil-containing oligonucleotide template molecule having a sequence that is complementary to a part of a target single-stranded DNA molecule of length greater than the template molecule; providing one or more parts of the target molecule including... Agent: Kirby Eades Gale Baker

20080118929 - Tif1-beta peptides and nucleic acids for diagnosis and therapy of cancer and colorectal cancerous disorders: Many disorders, especially neoplastic disorders such as cancer and polyps, are the result of hyperproliferative cells or of cells with differentiation disorders. For these types of disorders early detection is of pivotal importance and reliable and early biomarkers for common types of cancers such as colorectal cancer are still not... Agent: Sills Cummis Epstein & Gross P.c.

20080118925 - Tools and methods for the quantification of dna repeats: The invention relates to an assay method allowing the quantification of the copy number of a repeated nucleic acid sequence in a genetic sample. Typically such sample comprises the genome of a microbial, plan, animal or human subject. Furthermore, the invention provides a particular example wherein the assay is used... Agent: Bacon & Thomas, Pllc

20080118924 - Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases: The present invention relates to methods for the diagnosis and evaluation of subclinical atherosclerosis. In particular, patient test samples are analyzed for the presence and amount of one or more natriuretic peptides. A variety of additional markers are disclosed for assembling a panel of markers for such diagnosis and evaluation.... Agent: Foley & Lardner LLP

20080118919 - Yeast bacterial two-hybrid system and methods of use thereof: A combined yeast/bacterial two-hybrid system is disclosed.... Agent: Dann, Dorfman, Herrell & Skillman

20080118932 - Methods of analyzing glycomolecules: The invention relates to methods for analyzing glycomolecules such as glycoproteins, and glycan structures associated with preparations of such glycomolecules.... Agent: Fish & Richardson Pc

20080118930 - Screening method for agents capable of reversing fusidic acid resistance in bacteria: A screening method for agents which are capable of reversing resistance to the antibiotic fusidic acid in bacteria that contain the fusB resistance gene or a homologue thereof and that express the FusB fusidic acid resistance protein or a homologue thereof based on the interaction between the fusB resistance protein... Agent: Myers Bigel Sibley & Sajovec

20080118931 - Stabilized ornithine transcarbamylase and immunoassay method for ornithine transcarbamylase using the same: A method for stabilizing ornithine transcarbamylase (OTC) and a method of immunologically assaying OTC are provided. More specifically, the application provides a stabilized OTC solution having a pH of 5.5 to 7.0 as well as an immunological assay method of OTC including reacting an OTC antigen with an anti-OTC antibody... Agent: Bell, Boyd & Lloyd, LLP

20080118935 - Methods and compositions for diagnosing neoplastic disease: Methods and compositions for determining whether a subject at least has a neoplastic disease are provided. In practicing the subject methods, a sample from a subject is assayed for a soluble filamin analyte, such as a filamin A analyte, to determine whether the subject at least has the neoplastic disease.... Agent: Invitrogen Corporation C/o Intellevate

20080118934 - Sequential analysis of biological samples: Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one fluorescent probe to one or more target present in the sample, and binding at least at least one control probe to one... Agent: General Electric Company Global Research

20080118936 - Polyclonal antibodies against fibrinogen degradation products and associated methods of production and use: Monospecific polyclonal fibrinogen degradation product antibodies, their method of use, the methods to detect cancer and for monitoring the progress of anticancer treatment by immunochemically measuring the quantity of serum FDP in serum are disclosed. The present invention teaches that monospecific polyclonal FDP antibodies that bind to human fibrinogen degradation... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20080118937 - Antibody with protein a selectivity: Monoclonal antibodies, and antigen binding fragments thereof, which bind to Protein A of Staphylococcus aureus are provided.... Agent: 3m Innovative Properties Company

20080118938 - Methods and compositions for the detection of protein folding disorders: A method is provided for the detection of misfolded proteins in a sample. These methods may be used to diagnose or indicate the potential for developing a disease associated with protein aggregation. In particular a method for serial automated cyclic amplification of a misfolded protein is disclosed.... Agent: Fulbright & Jaworski L.l.p.

20080118939 - Conjugate and its use as a standard in an immunoassay: A composition comprising a conjugate of an anti-idiotype antibody specifically binding to a CDR region of a parent antibody and method of using polyclonal human serum immunoglobulin of class E, G, M, or A, and the use of said composition as a standard in an immunoassay is presented.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20080118940 - Proteasomal peptidase activity and the use thereof in clinical applications: Provided herein are methods for the diagnosis, prognosis, or management of hematological disorders and other diseases using the proteasome activity levels determined in acellular body fluids or cell-containing samples. Also provided are methods of monitoring treatment with proteasome inhibitors through assaying proteasome activity in acellular body fluids. Further provided are... Agent: Foley & Lardner LLP

20080118943 - Bacteria that naturally overproduce folate: The present invention relates to the mutant bacteria comprising high levels of folate and being resistant to methotrexate. Also provided are food and food supplement compositions comprising these bacteria and methods for isolating mutant bacteria.... Agent: Sughrue Mion, Pllc

20080118942 - Method of determining level of specified component in blood sample and apparatus for level determination: The present invention relates to a method for measuring the concentration of a particular component in a blood sample containing blood cells based on a variable correlated with the concentration of the particular component. In the present invention, a concentration (S) in blood plasma obtained by removing blood cell components... Agent: Hamre, Schumann, Mueller & Larson, P.c.

20080118944 - Sequential analysis of biological samples: Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets adhered to a solid support, binding at least one fluorescent probe to one or more target present in the sample, and observing a signal from the... Agent: General Electric Company Global Research

20080118941 - Signal peptide-semiconductor nanocrystal conjugates: The present invention provides signal peptide-semiconductor nanocrystal-peptide conjugates and methods for using the conjugates in methods for imaging live cells and subcellular trafficking processes.... Agent: Townsend And Townsend And Crew, LLP

20080118946 - System and method for mixing high viscous liquids with gas: A system and method for mixing high viscous liquids with gas is provided. The disclosed embodiments include a reactor or mixing vessel having a draft tube disposed therein, a gas injection subsystem adapted to inject gas into the reactor or mixing vessel proximate the entrance of the draft tube. The... Agent: Praxair, Inc. Law Department - M1 557

20080118947 - Method of separating collagen from the various animal tissues for producing collagen solution and product using the same: A method for separation the collagen from the various animal tissues is disclosed for preparing collagen solution and product using the same. The porcine tissues are processed to have proper form and size for acid-treatment. The acid-treatment is repeated with pepsin to separate type I or II collagens. The separated... Agent: Gwips Peter T. Kwon

20080118949 - Intracellular production of a nuclease: Methods and compositions are provided that relate to obtaining a recombinant DNA and RNA cleaving nuclease. This involves the over-expression of a fusion protein between maltose-binding protein and a truncated nuclease in a soluble form in the cytoplasm of a host cell from which it can be readily extracted.... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20080118950 - Method for production of a heterologous protein using yeast-type host cells: A heterologous protein is produced by a method in which yeast-type host cells are prepared, which, in addition to the at least one endogenous homologous DNA sequence coding for a first calnexin, includes at least one recombinant DNA sequence coding for the protein and at least one additional recombinant DNA... Agent: Fay Sharpe LLP

20080118951 - Nogo receptor homologues and their use: This invention relates to gene polypeptides and polynucleotides that encode proteins of the Nogo-66 receptor (NgR) family and are therefore called NgR homologue 2 (NgRH2). The invention further relates to their use in identifying compounds that may be agonists or antagonists that are potentially useful in regeneration and protection of... Agent: Novartis Corporate Intellectual Property

20080118948 - P ef-tu expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP

20080118953 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20080118955 - Method for precise temperature cycling in chemical / biochemical processes: A method for implementing a temperature cycling operation for a biochemical sample to be reacted includes applying an infrared (IR) heating source to the biochemical sample to be reacted at a first infrared wavelength selected so as to generate a first desired temperature for a first duration and produce a... Agent: Cantor Colburn LLP - Ibm Fishkill

20080118956 - Viral particles containing an alphavirus-derived vector and method for preparing said viral particle: Viral particle consisting of structural elements not derived from an alphavirus and containing an alphavirus-derived vector made replication-defective by deletion, or replacement with at least one transgene, of the structural genes, characterized in that the structural elements of said particle are not encoded by the genome of the alphavirus-derived vector.... Agent: Mathews, Shepherd, Mckay, & Bruneau, P.a.

20080118957 - Process for the production of maltodextrins and maltodextrins: There is disclosed a process for preparing liquid maltodextrin having a D.E. of about 5 to less than about 20, Also disclosed are liquid maltodextrins having a D.E. of about 9 to about 15.... Agent: Cargill, Incorporated

20080118933 - Methods of screening for inhibitors of antiplasmin cleaving enzyme: Novel inhibitors of circulating APCE can diminish α2AP inhibitory capacity within forming fibrin or blood clots thereby making fibrin deposits or blood clots more susceptible to removal by plasmin. Patients who are susceptible to atherosclerotic plaque formation or are susceptible to developing thrombi that compromise organ function will benefit by... Agent: Dunlap Codding & Rogers, P.c.

20080118945 - Use of gelsolin to treat infections: The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods for down-regulating pro-inflammatory cytokine expression.... Agent: Wolf Greenfield & Sacks, P.c.

20080118952 - Polynucelotides encoding novel variants of the trp channel family member, ltrpc3: The present invention provides novel polynucleotides encoding LTRPC3g, LTRPC3h, LTRPC3i, LTRPC3j, LTRPC3k, or LTRPC3l polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3g, LTRPC3h,... Agent: Louis J. Wille Bristol-myers Squibb Company

20080118954 - Transgenic cover plants containing hemicellulase and cellulase which degrade lignin and cellulose to fermentable sugars: The present invention provides transgenic cover crop plants which after harvest degrade the hemicellulose and cellulose therein to fermentable sugars which can further be fermented to ethanol or other products. In particular, the transgenic plants comprise cellulase, hemicellulase and optionally ligninase genes from microbes operably linked to a DNA encoding... Agent: Ian C. Mcleod Ian C. Mcleod, P.c.

20080118958 - Method for producing an l-tyrosine over-producing bacterial strain: An enteric bacterial strain was engineered to over-produce L-tyrosine using a one-step method. The pheA-tyrA chromosomal region of the bacterial genome was replaced with an engineered chromosomal segment, resulting in inactivation of the pheA coding region and strong expression of the tyrA coding region, resulting in high levels of L-tyrosine... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080118959 - Method for the production of sulpher-containing fine chemicals by fermentation: The invention relates to methods for the production of sulfur-containing fine chemicals, in particular L-methionine, by fermentation using bacteria in which a nucleotide sequence encoding an S-adenosylmethionine synthase (metK) gene is expressed.... Agent: Novak Druce Deluca + Quigg LLP

20080118960 - Novel gene sms 04: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also refeixed to as Vitamin C), The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, Pc

20080118961 - Biodiesel production from soapstock: A process for the production of fatty acid esters from any soapstock generated in the alkali refining process of soybean, sunflower, rice, corn, coconut, palm kernel, rapeseed or cotton oils, which soapstock comprises water, about 0.1-2.0%, fatty derivatives, including glycerides, neutralizing and splitting the soaps with strong acids, followed by... Agent: Cognis Corporation Patent Department

20080118962 - Process for the synthesis of cis-1,3-diols: A process for selectively reducing beta-hydroxy ketones, using a ketone reductase obtained from: Monosporium, Rhodococcus, Lechevalieria, Fusarium, Sporidiobolus, Streptomyces, Absidia, or Rhodotorula, to obtain the corresponding cis-1,3-diol. A purified ketone reductase obtained from an organism of the genera Monosporium, Rhodococcus, Lechevalieria, Fusarium, Sporidiobolus, Streptomyces, Absidia, or Rhodotorula.... Agent: Pfizer Inc.

20080118963 - Method of coagulating poly-3-hydroxyalkanoic acid: The present invention has for its object to provide a method for agglomerating particles of a poly-3-hydroxyalkanoic acid and enlarging its particle size. The present invention provides a method for agglomerating a poly-3-hydroxyalkanoic acid which comprises suspending particles of the poly-3-hydroxyalkanoic acid in a hydrophilic solvent or a mixture comprising... Agent: Kenyon & Kenyon LLP

20080118964 - Continuous-batch hybrid process for production of oil and other useful products from photosynthetic microbes: A process for cultivating photosynthetic microbes comprising Closed Systems for continuous cultivation and Open Systems for batch cultivation, in which (a) the Closed System Area occupies no more than 20% of the Total Land Area of the cultivation facility; (b) batch cultures in the Open Systems are initiated with an... Agent: Martin E Hsia Cades Schutte A Limited Liability

20080118965 - Method for producing a compound of interest in a filamentous fungal cell: The invention relates to a nucleotide sequence comprising: a synonymous nucleotide coding sequence with optimized codon frequency such that a native codon has been exchanged with a synonymous codon, said synonymous codon encoding the same amino acid as the native codon and having a higher frequency in codon usage as... Agent: Nixon & Vanderhye, Pc

20080118966 - Luminescent diamond particles: A method for preparing luminescent diamond particles (e.g., fluorescent nanodiamonds). The method includes irradiating diamond particles with an ion beam and heating the irradiated diamond particles in a non-oxidizing atmosphere at a temperature between 600 and 1000° C. The diamond particles have a diameter of 1 nm to 1 mm... Agent: Occhiuti Rohlicek & Tsao, LLP

20080118967 - Magnetic enrichment method, a reactor unit for micro particles and a magnet unit: Magnetic enrichment method, wherein the desired biological component is collected from a solution, which component is thereafter enriched in a liquid in such a manner that by means of the micro particles attached to the magnet or attached by means of at least one magnet at least one biological component... Agent: Kubovcik & Kubovcik

20080118968 - Nucleic acid sequences from cyanidium caldarium and uses thereof: Expressed Sequence Tags (ESTs) isolated from the unicellular red algae, Cyanidium caldarium, are disclosed. The invention encompasses nucleic acid molecules that encode Cyanidium caldarium protein homologs and fragments therof. In addition, antibodies capable of binding the proteins are encompassed by the present invention. The disclosed ESTs have particular utility in... Agent: Arnold & Porter, LLP

20080118969 - Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV)... Agent: Banner & Witcoff, Ltd.

20080118970 - Methods of adenovirus purification: A process for purifying virus particles, especially recombinant adenovirus vector particles, is presented. The process relies on various combinations of cell lysis, detergent-based precipitation of host cell contaminants away from the virus, depth filtration or centrifugation, ultrafiltration, nuclease digestion and chromatography to robustly and economically produce highly purified product. This... Agent: Merck And Co., Inc

20080118971 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20080118972 - Method and apparatus for isolating and purifying nucleic acid using a single surface: Provided is a method of isolating nucleic acid from cells using a single surface, wherein a compound represented by Formula 1 is bound to the surface. Also provided are an apparatus for isolation of nucleic acids, and a bead for isolating nucleic acids.... Agent: Cantor Colburn, LLP

20080118973 - Optical biosensor: The present invention relates to an optical biosensor comprising a porous matrix. In the specific case, reference is made to anodized porous alumina, on the surface of which the biological component specific for the analyte in question is immobilized, and to an optical-signal detector connected to said matrix. The present... Agent: Sughrue Mion, Pllc

20080118974 - Large scale cell culture vessel: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of flexible cell culture compartments in combination with a spacer material maintaining air space(s). The expandable compartments of the cell culture apparatus have imparted therein... Agent: Corning Incorporated

20080118975 - Sulfotransferase 2b1 pharmacogenetics: Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as are sulfotransferase allozymes. Methods for determining the sulfonator status of a subject also are described. In addition, methods for predicting the therapeutic efficacy of a compound in a subject are... Agent: Fish & Richardson P.c.

20080118976 - Carrier for undifferentiated cell culture and subculture method thereof: A colony (cell mass) proliferated under the undifferentiated state is obtained by using a carrier for cell culture in which two or more of a concavity having a porous body in a surface are arranged on a substrate surface in the form of a matrix, inoculating an undifferentiated cell on... Agent: Foley And Lardner LLP Suite 500

20080118977 - Process to cary out a cellular cardiomyoplasty: A cellular cardiomyoplasty process based on the potential capacity of CD34+ cells to regenerate myocardium after acute myocardial infarct (AMI) and on their collection in blood in which the following phases are performed: Phase 1 a G-CSF-mobilization phase of CD-34+ cell is started as soon as the infarct is stabilized... Agent: Davis Bujold & Daniels, P.l.l.c.

20080118978 - Anti-tumor agent: The present invention provides an agent which is effective to a patient who is administered by an agent comprising anti-CD20 antibody as an active ingredient.... Agent: Morgan Lewis & Bockius LLP

20080118979 - Methods of regulating expression of genes or of gene products using substituted tetracycline compounds: The present invention relates, at least in part, to the use of substituted tetracycline compounds for regulation of expression of nucleic acids operably linked to a tetracycline operator system. The invention pertains to compounds used in a regulatory system which utilizes components of the Tet repressor/operator/inducer system of prokaryotes to... Agent: Lahive & Cockfield, LLP

20080118980 - Estrogen enhancing differentiation of human mesenchymal stromal cells and adipose-derived stromal cells: Adipose-derived stromal cells and bone marrow mesenchymal stem cells possess multiple differentiation potentials and can provide tissues for regenerative medicine and tissue engineering. The present invention provides a method of enhancing the differentiation and proliferation of adult stem cells, such as adipose-derived stromal cells and bone marrow mesenchymal stem cells,... Agent: Greenlee Winner And Sullivan P C

20080118981 - Methods for producing transgenic plants: A method of producing a stably transformed corn plant in a single container is demonstrated. This method allows for the automation of the transformation process and reduces labor, material, and ergonomic costs associated with traditional plant tissue culture systems.... Agent: Fulbright & Jaworski, L.l.p.

20080113331 - System, device, and method for mixing a substance with a liquid: A system, device, and method for mixing a substance with a liquid pumps the liquid into a container of the substance to produce a solution. The container may be part of a container assembly including a port assembly for coupling with the container to produce an inlet and/or and outlet... Agent: Michelle Saquet Temple

20080113333 - Method for preventing the adhesion of particles: A method for the prevention of the adhesion of particles, in particular cells and cellular components in solution to surfaces, characterized in that to the solution is added at least one polyalcohol.... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20080113332 - Method of using density maps based on marker values for the diagnosis of patients with diseases, and in particular tumors: The invention relates to a method of using density maps based on marker values, and in particular tumour markers and other indicator substances/values for the diagnosis of patients with diseases, in particular tumourous diseases, and especially prostate carcinoma.... Agent: Morgan & Finnegan, L.l.p.

20080113334 - Test method using cells and test kit therefor: The present invention provides a method for performing a biological test under conditions in which an artificially prepared cell pattern with initial position coordinates that can be determined is three-dimensionally cultured within a gelled matrix. The present invention relates to a biological test method that comprises testing a biological indicator... Agent: Sughrue Mion, Pllc

20080113339 - Combination hepatitis c virus antigen and antibody detection method: An in vitro method that allows detection of hepatitis C by detecting hepatitis C virus (HCV) core protein and antibodies to HCV core protein (anti-core antibodies) in a single assay is provided. Cross-reactivity is eliminated in the method preferably by utilizing short peptides, each of which has an amino acid... Agent: Paul D. Yasger Abbott Laboratories

20080113336 - Detection of intact recombinant viruses: In accordance with the present invention, there is provided a new method for detection and quantification of virus and viral particles, comprising the step of labeling the nucleic acids of an intact virus or viral particle with a dye that emits fluorescence once complexed with the nucleic acids and detecting... Agent: Ogilvy Renault LLP

20080113338 - Determination of risk of developing dengue hemorrhagic fever/dengue shock syndrome, methods and compositions therefor: The present specification discloses methods of determining risk of developing Dengue Hemorrhagic Fever/Dengue Shock Syndrome (DHF/DSS) in an individual infected with dengue virus (DV). The methods comprise determining, in a fluid or tissue sample of an individual, the presence, absence or quantity of dengue virus protein NS1, and determining, in... Agent: Sonnenschein Nath & Rosenthal LLP

20080113337 - Method of examining/judging presence of virus infection such as hiv or presence of prion infection by near-infrared spectroscopy and device used in same: The present invention provides a method and device of quantitatively or qualitatively examining and judging the presence of virus infection, such as HIV, or the presence of prion infection by: irradiating a sample derived from an examinee or other animal with light having a wavelength in a range of 400... Agent: Kirk Hahn

20080113335 - Novel hiv-based recombinant viral clones and use thereof in analytical methods: e

20080113353 - Biomolecule interaction using atomic force microscope: The present patent application describes a cantilever for atomic force microscopy (AFM), which includes a cantilever body having a fixed end and a free end, the free end having a surface region being chemically modified by a dendron in which a plurality of termini of the branched region of the... Agent: Jhk Law

20080113350 - Blood test to monitor the genetic changes of progressive cancer using immunomagnetic enrichment and fluorescence in situ hybridization (fish): Amplification and overexpression of theHER-2 oncogene in breast cancer is felt to be stable over the course of disease and concordant between the primary tumor and metastases. Therefore, patients with HER-2 negative primary tumors will rarely receive anti-HER-2 antibody therapy. A very sensitive blood test is used to capture circulating... Agent: Immunicon Corporation

20080113367 - Clip based sampling of seed for the removal of specific seed tissue or structures for seed analysis: Apparatus, methods, and systems for useful sampling of seed, wherein viability is maintained, are disclosed. Seed from one generation in a plant advancement experiment is individually sampled by removal and collection of tissue from the seed using a hand-held and manually operated tool having one or more cutting edges. The... Agent: Mckee, Voorhees & Sease, P.L.C Attn: Pioneer Hi-bred

20080113359 - Dnazymes and sensors incorporating the same: An arsenic ion active DNAzyme includes a nucleotide sequence, which has a base sequence selected from ATCTCCTCCTGTTC (SEQ ID NO: 62), ATCTGCTCCTGTTC (SEQ ID NO: 63), ATCTCCTCATGTTC (SEQ ID NO: 64), ATCTCCTCTTGTTC (SEQ ID NO: 65), ATCTCCAACCTGTTC (SEQ ID NO: 66), and CCGTAGCGCAAAT (SEQ ID NO: 67). A mercury ion... Agent: Julia Church Dierker Dierker & Associates, P.c.

20080113352 - Electrochemical patterning on multi-channel microelectrode array for biosensing applications: Described is a method for electrochemically patterning a microelectrode array (MEA) with at least two different kinds of macromolecules. Said method comprising the steps of: providing a platform with a surface that comprises individually addressable conductive microelectrode surfaces; covering said platform surface with an adlayer of resistant polymer; desorbing said... Agent: Richard F Jaworski C/o Cooper & Dunham LLP

20080113357 - Filter device for the isolation of a nucleic acid: The invention relates to methods of isolating nucleic acids from a sample using a filter device comprising a plurality of membranes. The invention also provides for devices comprising a plurality of membranes and kits suitable for isolating nucleic acids from a sample. The invention also provides for nucleic acids which... Agent: Millipore Corporation

20080113346 - Marker gene for arthrorheumatism test: It is intended to identify rheumatoid arthritis susceptibility genes by a highly efficient, low-cost mapping method using microsatellites. In the present invention, novel rheumatoid arthritis susceptibility genes, that is, TNXB, NOTCH4, RAB6A, MPRL48, UCP2, and UCP3 genes, in the human genomic DNA sequence were identified by conducting case-control association analysis... Agent: Bozicevic, Field & Francis LLP

20080113360 - Melanoma gene signature: Methods and compositions for evaluating gene expression in melanoma samples are provided herein.... Agent: Fish & Richardson Pc

20080113348 - Method for cleaning and isolating nucleic using cationic detergents: t

20080113349 - Method for detecting the presence of mammalian organisms using specific cytochrome c oxidase i (coi) and/or cytochrome b subsequences by a pcr based assay: The present invention relates to a PCR (polymerase chain reaction) based assay that is useful for detecting, identifying, quantitating and analysis of a target nucleic acid (target nucleic acid hereinafter) in a sample. More specifically, the present invention relates to a PCR based assay that can improve accuracy in detecting,... Agent: Bio Intellectual Property Services (bio Ips) Llc

20080113347 - Method for the in vitro diagnosis and prognosis of demyelinating diseases, and for the development of drugs against demyelinating diseases: The present invention refers to an in vitro method for detecting the presence of demyelinating diseases in an individual, for determining the stage or severity of said diseases in the individual, or for monitoring the effect of the therapy administered to an individual suffering said diseases; to the search, identification,... Agent: Moore & Van Allen Pllc

20080113343 - Method of inhibiting prostate cancer cell proliferation: The present invention relates to a method of inhibiting or reducing the proliferation of prostate cancer cells, such as androgen independent prostate cancer (AIPC) cells, the method comprising administering to the cells a PLA2 inhibitor. In one embodiment the PLA2 inhibitor is a conformationally constrained molecule derived from a peptide... Agent: Nixon & Vanderhye, Pc

20080113368 - Method of modeling dna molecules: A set of relationships using properties of the DNA molecule and its hydrogen bridge electron cycloid motion tied to the Fibonacci-Lucas series concepts and a complex number Argand diagram to provide a computer-implemented set of numbers to describe the number of DNA molecular bases traveling away from a starting point,... Agent: Kenyon & Kenyon LLP

20080113356 - Method of separating and purifying nucleic acid: A method for separating and purifying a nucleic acid comprising steps of: (1) adding a lysis solution to a biomaterial to prepare a sample solution containing a nucleic acid, and adding a water-soluble organic solvent or a solution containing a water-soluble organic solvent to the sample solution thereby preparing a... Agent: Birch Stewart Kolasch & Birch

20080113354 - Methods and compositions for high sensitivity fluorescent mutation detection with mismatch cutting dna endonucleases: Methods and kits are provided with DNA substrates having a fluorescent label positioned at a nucleotide internal from its 5′ end for use with CEL nuclease to determine whether a DNA sequence contains mutations or polymorphic changes.... Agent: Licata & Tyrrell P.c.

20080113344 - Methods and compositions for the response prediction of malignant neoplasia to treatment: The invention provides novel compositions, methods and uses, for the prediction, diagnosis, prognosis, prevention and treatment of malignant neoplasia and breast cancer in particular. Genes that are differentially expressed in breast tissue of breast cancer patients versus those of normal people are disclosed.... Agent: Choate, Hall & Stewart LLP

20080113355 - Methods for detecting the presence of expanded cgg repeats in the fmr1 gene 5' untranslated region: The invention provides improved methods for detecting the presence of expanded CGG repeats in the fragile X mental retardation 1 (FMR1) gene and for quantifying the amount of protein produced by the gene.... Agent: Townsend And Townsend And Crew, LLP

20080113362 - Methods for isolating and characterizing endogenous mrna-protein (mrnp) complexes: Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex and include cell cultures, cell extracts, and whole tissue, including tumor... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080113351 - Polynucleotides for causing rna interference and method for inhibiting gene expression using the same: l

20080113361 - Post-synthesis processing system for supported oligonucleotides, and method: A system is provided that can include: a plurality of retainment regions, where each retainment region is adapted to retain a respective type of an oligonucleotide supported on a respective support; a mixture retainment region; a handling device; a control unit adapted to control the handling device; and a separating... Agent: Kilyk & Bowersox, P.l.l.c.

20080113345 - Predicting response and outcome of metastatic breast cancer anti-estrogen therapy: Gene signatures, specific marker genes, and diagnostic assays for predicting progression free survival and objective response to anti-estrogen, e. g., tamoxifen therapy for recurring breast cancer patients are described.... Agent: Merchant & Gould Pc

20080113363 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 70 to 72 and complementary or modified sequences thereof or a... Agent: Fitzpatrick Cella Harper & Scinto

20080113364 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 84 to 86 and complementary or modified sequences thereof or a... Agent: Fitzpatrick Cella Harper & Scinto

20080113365 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 76 to 77 and complementary or modified sequences thereof or a... Agent: Fitzpatrick Cella Harper & Scinto

20080113366 - Probe, probe set, probe-immobilized carrier, and genetic testing method: A nucleic acid probe for classification of pathogenic bacterial species is capable of collectively detecting bacterial strains of the same species and differentially detecting them from other bacterial species. Any one of the base sequences of SEQ ID NOS. 68 to 69 and complementary or modified sequences thereof or a... Agent: Fitzpatrick Cella Harper & Scinto

20080113358 - Selection of cells using biomarkers: The present invention provides systems, apparatuses, and methods to isolate, select or detect the presence of a target cell (e.g., fetal cells) in a sample comprising mixed populations of cells that vastly outnumber the target cells. Target cells include fetal cells, such as nucleated red blood cells, and methods of... Agent: Wilson Sonsini Goodrich & Rosati

20080113382 - Device and method for detecting the presence of hemoglobin in a biological sample: A device and method for detecting the presence of hemoglobin in a biological sample, more particularly, the presence of blood in a fecal sample as an indicator of upper or lower gastrointestinal tract bleeding.... Agent: Fish & Richardson Pc

20080113381 - Hemoglobin a1c determination method, enzyme to be used therefor, and production method thereof: d

20080113383 - Hif prolyl hydroxylase activity assay: The present invention provides methods for measuring EGLN activity. The invention also provides novel peptides for use in the methods, and use of the methods to identify agents which modulate EGLN activity.... Agent: Fibrogen, Inc. Intellectual Property Department

20080113384 - Methods and apparatus and assays of bacterial spores: A sample of unknown bacterial spores is added to a test strip. The sample of unknown bacterial spores is drawn to a first sample region on the test strip by capillary action. Species-specific antibodies are bound to the sample when the unknown bacterial spores match the species-specific antibodies, otherwise the... Agent: Richard P. Berg, Esq. C/o Ladas & Parry

20080113385 - Monoclonal antibodies against hmgb1: In various embodiments, the present invention is drawn to antibodies or antigen-binding fragments thereof that bind to a vertebrate high mobility group box (HMGB) polypeptide, methods of detecting and/or identifying an agent that binds to an HMGB polypeptide, methods of treating a condition in a subject characterized by activation of... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20080113387 - Immunoassay for prion disease: This invention relates to the detection or assessment of prion disease in an individual by determining the binding of monoclonal antibodies specific for PrP to the surface of blood cells obtained from the individual. The binding of such antibodies is shown to correlate with the progression of prion disease. Methods... Agent: Wolf Greenfield & Sacks, P.c.

20080113389 - Detecting the presence of pyruvate kinase isoenzyme in feces: In order to selectively, qualitatively or/and quantitatively detect the pyruvate kinase isoenzyme of the tumor M2-PK type (tumor M2-PK) which serves as a tumor marker in human and animal feces to detect a malignant process in the gastrointestinal tract, tumor M2-PK is detected in a stool specimen by an immunoassay... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080113390 - Personalized assay for the identification of an effective therapy for cancer: Effective anticancer agents for use in treatment of particular cancers can be predicted by testing whether particular anticancer agents are effective in reducing the lactic acid production by sample cells removed from the particular cancerous tissue to be treated. Similarly, effective anticancer agents can be predicted by testing whether particular... Agent: Thorpe North & Western, LLP.

20080113388 - Nematode atp synthase subunit e-like sequences: Nucleic acid molecules from nematodes encoding ATP synthase subunit E polypeptides are described. ATP synthase subunit E-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of ATP synthase subunit E-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators,... Agent: Fish & Richardson Pc

20080113391 - Detection and quantification of analytes in bodily fluids: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.... Agent: Wilson Sonsini Goodrich & Rosati

20080113397 - Enzymatic measurement of imatinib mesylate: The present invention provides a method for the enzymatic measurement of protein tyrosine kinase inhibitors in biological samples. The present invention also provides assay reagents and packaged kits useful for performing enzymatic measurement of imatinib mesylate and other bcr-abl protein kinase inhibitors in biological samples.... Agent: Gibbons P.c.

20080113396 - Kits and peptides for transferases: Kits and peptide substrates for detecting transferase activity of a sample are provided. The kits include a substrate including a reporter compound, at least one of a phosphate group donor and a phosphate group acceptor, a buffer that supports enzymatic activity of the transferase, and a peptidase that cleaves a... Agent: Whyte Hirschboeck Dudek S.c.

20080113401 - Cell-based assay for the detection of toxic analytes: Assays for detecting potentially toxicdanalytes utilize a preparation of eukaryotic or prokaryotic cells which have signal-generating metabolic activity. The sensitivity of such assays is significantly improved by the employment of a particulate solid-phase adsorbent e.g. silica gel, which can be preliminarily mixed either with the suspected toxic analyte or with... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20080113400 - Methods and devices for culturing stem cells: Methods are described for the cultivation of stem cells (2, 3, 5), comprising the steps: Introduction of cell material comprising at least one stem cell (2, 3, 5) of a donor organism into a host egg (4) with a nutrient reservoir, and cultivation of the cell material in the host... Agent: Pearl Cohen Zedek Latzer, LLP

20080113403 - Infrared measurement for the rapid enumeration of microbial concentrations: A method for testing for presence of a microbe in a sample includes measuring an instantaneous transmission rate of two or more wavelengths through the sample (1403), providing predetermined transmission rates corresponding to positive or negative samples for the presence of the microbe for each of the two or more... Agent: Wallace & Wallace

20080113404 - Device and method for the detection and enumeration of multiple groups of microorganisms: A device and method simultaneously detects and enumerates two groups of microorganisms in a test sample, utilizing a single test container. In the container liquid growth media, a chromogenic substrate and a fluorogenic substrate are mixed with the test sample. The test container is incubated to allow bacterial growth and... Agent: John R. Benefiel

20080113405 - Gene-cassette for enhancement of protein production: There are disclosed methods and compositions for gene expression and enhancement of protein production and/or accumulation. The invention provides gene-cassettes and methods of introducing the same into host cells for enhanced expression of target genes and production and/or accumulation of encoded proteins or peptides, or the like.... Agent: Office Of Technology Transfer National Institutes Of Health

20080113407 - Genetically programmed expression of selectively sulfated proteins in eubacteria: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods... Agent: Quine Intellectual Property Law Group, P.c.

20080113406 - Modified bacteriocins and methods for their use: Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners, or receptors, such as those on the surface of... Agent: Townsend And Townsend And Crew, LLP

20080113408 - Biosynthetic polypeptide fusion inhibitors: Modified biosynthetic polypeptide fusion inhibitors, methods for manufacturing, and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080113409 - Transient protein expression methods: Described is a method for producing a protein of interest, the method comprising: a) providing a recombinant adenoviral vector comprising nucleic acid encoding the protein of interest under control of a promoter, wherein the adenoviral vector has deletions in a first region and in a second region of the adenovirus... Agent: Trask Britt

20080113410 - Method for rational pegylation of proteins: The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method.... Agent: Morgan, Lewis & Bockius, LLP

20080113411 - Modified human plasma polypeptide or fc scaffolds and their uses: Modified human plasma polypeptides or Fc and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080113412 - Modified human plasma polypeptide or fc scaffolds and their uses: Modified human plasma polypeptides or Fc and uses thereof are provided.... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080113413 - Expression of foreign cellulose synthase genes in photosynthetic prokaryotes (cyanobacteria): The present invention includes compositions and methods for making and using cyanobacteria that include a portion of an exogenous cellulose operon sufficient to express cellulose. The compositions and methods of the present invention may be used as a new global crop for the manufacture of cellulose, CO2 fixation, for the... Agent: Chalker Flores, LLP

20080113340 - Diagnosis and treatment of cervical cancer: In certain aspects, the invention relates to methods of diagnosing cervical cancer by using a combination of certain biomarkers such as hTERT, IGFBP-3, transferrin receptor, beta-catenin, Myc-HPV E6 interaction, HPV E7, and telomere length. In other aspects, the invention relates to methods of detecting immortalization of cervical cells by using... Agent: Wolf Greenfield & Sacks, P.c.

20080113341 - Fluorinated resorufin compounds and their application: The invention provides novel fluorinated resorufin compounds that are of use in a variety of assay formats. Also provided are methods of using the compounds and kits that include a compound of the invention and instructions detailing the use of the compound in one or more assay formats.... Agent: Invitrogen Corporation C/o Intellevate

20080113379 - Method for the detection of cytosine methylations in immobilized dna samples: A method is described for the analysis of cytosine methylation patterns in genomic DNA samples. In the first method step, the genomic DNA is isolated from cells or other accompanying materials and bound essentially irreversibly to a surface. Then the DNA bound to the surface is treated, preferably with a... Agent: Kriegsman & Kriegsman

20080113342 - Plant genome sequence and uses thereof: The present invention is in the field of plant biochemistry and genetics. More specifically the invention relates to nucleic acid sequences from plant cells, in particular, genomic DNA sequences from Arabidopsis thaliana plants. The invention encompasses nucleic acid molecules present in non-coding regions as well as nucleic acid molecules that... Agent: Arnold & Porter, LLP

20080113380 - Sensitizer-labeled analyte detection: The invention provides methods for detecting an analyte in a sample including the steps of: (a) exciting a sensitizer label on an analyte; (b) permitting energy from the excited sensitizer label to be transferred to and excite an acceptor molecule, whereby the sensitizer label returns to an unexcited state; (c)... Agent: Hoffmann & Baron, LLP

20080113373 - Sirna targeting amyloid beta (a4) precursor protein (app): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080113370 - Sirna targeting apolipoprotein b (apob): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080113371 - Sirna targeting beta secretase (bace): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080113369 - Sirna targeting diacylglycerol o-acyltransferase homolog 2 (dgat2): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080113374 - Sirna targeting fructose-1,6-bisphosphatase 1 (fbp1): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080113372 - Sirna targeting glucagon receptor (gcgr): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080113378 - Sirna targeting interleukin-1 receptor-associated kinase 4 (irak4): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080113376 - Sirna targeting myeloid differentiation primary response gene (88) (myd88): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080113377 - Sirna targeting proto-oncogene met: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080113375 - Sirna targeting superoxide dismutase 1 (sod1): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20080113386 - Predicting diabetic nephropathy: The invention relates to methods and compositions for identifying subjects who are predisposed to having diabetic nephropathy (DN).... Agent: Fish & Richardson Pc

20080113392 - Assays for cancer patient monitoring based on levels of analyte components of the plasminogen activator system in body fluid samples: The present invention describes clinically and medically important methods of examining, screening over time, and monitoring the outcome of a cancer patient who is undergoing treatment or therapy for his or her disease. More specifically, the invention provides a method of monitoring the progression of disease, or the effectiveness of... Agent: Siemens Corporation Intellectual Property Department

20080113395 - Methods for diagnosing bi-polar disorder: The invention relates to the use of Reelin as a marker for diagnosing psychiatric conditions. The disclosed tools and techniques can facilitate the diagnosis of psychiatric disorders including major depression, bipolar disorder, schizophrenia and autism.... Agent: Fish & Richardson P.c.

20080113394 - Methods for diagnosing major depression: The invention relates to the use of Reelin as a marker for diagnosing psychiatric conditions. The disclosed tools and techniques can facilitate the diagnosis of psychiatric disorders including major depression, bipolar disorder, schizophrenia and autism.... Agent: Fish & Richardson P.c.

20080113393 - Methods for diagnosing schizophrenia: The invention relates to the use of Reelin as a marker for diagnosing psychiatric conditions. The disclosed tools and techniques can facilitate the diagnosis of psychiatric disorders including major depression, bipolar disorder, schizophrenia and autism.... Agent: Fish & Richardson P.c.

20080113398 - Apparatus and method for quantitatively analyzing enzyme inhibitor: A method and an apparatus for quantitatively analyzing an enzyme inhibitor are provided. The apparatus includes a memory unit for storing at least one set of parameters, an interface for receiving a test strip, a reflective type optical detection unit for providing a light beam onto the test strip to... Agent: Reed Smith LLP

20080113399 - Novel 27875, 22025, 27420, 17906, 16319, 55092 and 10218 molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced,... Agent: Millennium Pharmaceuticals, Inc.

20080113402 - Magnetic particle capture of whole intact organisms from clinical samples: A method includes providing a sample containing at least one whole, intact particle or organism in a container; creating a mixture comprising the sample, at least one magnetically-responsive particle, and a remainder; and providing the mixture with a pH of less than about 7.0. By providing the mixture with a... Agent: David W. Highet Becton Dickinson And Company

20080113414 - Solid or semi-solid state fermentation of xanthan on potato or potato waste: The present invention presents a method for the aerobic production of xanthan by bacteria of the genus Xanthomonas on a solid or semi-solid substrate. In the exemplary embodiment of the method, a substrate is provided that has a total solids content of about 6.5% or higher. The substrate is sterilized... Agent: Kinney & Lange, P.a.

20080113415 - Glucose isomerase mutants: This invention describes a series of recombinant Thermoanaerobacterium saccharolyticum glucose isomerases having improved catalytic activity and thermostability. The recombinant glucose isomerases can be used for direct production of fructose syrup containing 55 wt % or higher concentration of fructose, or used for the production of fructose syrup containing less than... Agent: Nath & Associates

20080113416 - Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging the genus Escherichia or Pantoea, wherein said bacterium has attenuated expression of a gene encoding a toxin of a bacterial toxin-antitoxin pair.... Agent: Cermak & Kenealy LLP Acs Llc

20080113417 - Gene sms 12: The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the... Agent: Nixon & Vanderhye, Pc

20080113418 - Processes for producing a fermantation product: The present invention relates to processes for producing a fermentation product, such as ethanol, from milled starch-containing material comprising (a) saccharifying the milled starch-containing material with a glucoamylase having an amino acid sequence shown in SEQ ID NO: 2, or a glucoamylase being at least 70% identical thereto, at a... Agent: Novozymes North America, Inc.

20080113419 - Production of fatty acid alkyl esters by use of two lipolytic enzymes: A method for producing fatty acid alkyl esters, wherein a solution comprising triglyceride and alcohol is contacted with a first lipolytic enzyme having a relatively higher activity on free fatty acids than on triglyceride and a second lipolytic enzyme having a relatively higher activity on triglyceride than on free fatty... Agent: Novozymes North America, Inc.

20080113420 - Electrocompetent cells prepackaged for electroporation: Electrocompetent cells are prepackaged in a sterilized cuvette, and the cell contents frozen, such that electroporation can be performed simply by first thawing the cuvette contents, then electrically connecting the cuvette to a power source suitable for electroporation. The cuvette contains, in addition to the cells, a suspending medium, and... Agent: Townsend And Townsend And Crew, LLP

20080113421 - Stabilizing proteins against denaturation and inactivation by charged detergents using chemical modifications, including modifications that increase net charge: The present invention generally relates to enzymes and other proteins resistant to denaturation, and techniques for making and using the same. In one aspect, lysine and/or other charged residues within an enzyme are reacted in some fashion, which can render the enzyme more resistant to denaturation. For example, the lysine... Agent: Wolf Greenfield & Sacks, P.c.

20080113422 - Crystallographic structure of tcpraca and uses therefor: The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided, as are the drugs that are identified.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080113423 - Method of treating radioactive waste: This invention relates to a method of treating irradiated material which includes reducing irradiated material to particulate form, suspending the particulate irradiated material, or derivatives thereof, in a fluid to form a suspension, and removing radioisotopes from the suspension by biological treatment.... Agent: Millen, White, Zelano & Branigan, P.c.

20080113424 - Method for purifying modified major mite allergen: A method for purifying a modified major mite allergen obtained by the genetic recombination technique and a purified modified major mite allergen obtained by said method for purification are provided. A method for purifying a modified major mite allergen obtained by the genetic recombination technique, which comprises the purification steps:... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080113425 - Container for samples of organic tissue: m

20080113426 - Advanced tissue engineering system: The invention is an automated advanced tissue engineering system that comprises a housing in which one or more tissue engineering modules are accomodated together with a central microprocessor that controls functioning of the tissue engineering modules. In one embodiment, the tissue engineering module comprises a housing supporting one or more... Agent: Nath & Associates

20080113427 - Fecal occult test packaging: A specimen testing device, comprising: a folding top having a top inside and a top outside; a back portion having at least one flap opening in communication with the folding top; a front portion having at least one opening with the folding top covering the front portion and the front... Agent: Meredith & Keyhani, Pllc

20080113428 - Novel polypeptide hormone phosphatonin: The present invention relates to a novel human protein called phosphatonin, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this... Agent: Bozicevic, Field & Francis LLP

20080113429 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20080113430 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20080113431 - Methods and compositions for cryopreserving oocytes: Disclosed are methods and compositions useful for cryopreserving oocytes and, in particular, mammalian oocytes such as human oocytes.... Agent: Foley & Lardner LLP

20080113432 - Methods and compositions for reanimating cryopreserved oocytes: Disclosed are methods and compositions useful for thawing cryopreserved oocytes and, in particular, mammalian oocytes such as human oocytes.... Agent: Foley & Lardner LLP

20080113433 - Compositions and methods useful for culturing differentiable cells: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.... Agent: Invitrogen C/o Intellevates Sughrue Mion Pllc

20080113434 - Serum-free suspension culture system for mesenchymal progenitor cells: Non-hematopoietic, e.g., mesenchymal progenitor cells, are expanded under non-static, non-adherent conditions in serum-deprived medium.... Agent: Dimock Stratton LLP

20080113435 - Method for inducing differentiation to skeletal muscle cells: A method of efficiently and conveniently inducing differentiation from bone marrow stromal cells to skeletal muscle cells, which comprises the steps of: (a) the step of adding one or more kinds of substances selected from the group consisting of a cyclic AMP increasing agent, a cAMP analogue, and a cell... Agent: Greenblum & Bernstein, P.L.C

20080113436 - Buffer solution for electroporation and a method comprising the use of the same: A buffer solution for suspending animal or human cells and for dissolving biologically active molecules in order to introduce said biologically active molecules into the cells using electric current. The buffer solution includes at least one of sodium succinate, mannitol and sodium lactobionate. The buffer solution has a buffer capacity... Agent: Darby & Darby P.c.

20080113437 - In-vitro method for producing oocytes or eggs having targeted genomic modification: The invention relates to an in vitro method for introducing a targeted genome modification into an oocyte or an egg and a method for performing a random insertion in the genome of a host cell.... Agent: Harness, Dickey & Pierce, P.L.C

20080108044 - In vitro differentiation of hematopoietic cells from primate embryonic stem cells: Methods and compositions of CD45-positive hematopoietic cells and hemangioblasts derived b)y culturing human or non-human primate embryonic stem cells under serum-free conditions in cytokine-rich differentiation medium containing fibroblast growth factor or a related growth factor.... Agent: Quarles & Brady LLP

20080108043 - Rapid tissue processing system: A method for processing a biological tissue specimen using either manual or automated processing. The tissue specimen is sequentially contacted with components of a reagent system in the presence of increased temperature and/or agitation and in the absence of exogenous microwave radiation to facilitate processing in less than one working... Agent: Thompson Hine L.l.p. Intellectual Property Group

20080108050 - Influenza a virus vaccines and inhibitors: The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are... Agent: Chalker Flores, LLP

20080108051 - Methods and reagents for diagnosing hantavirus infection: Novel methods and immunodiagnostic test kits for the detection of hantavirus infection are disclosed. The methods and kits employ combinations of recombinant N and/or G1 antigens from at least six different hantavirus serotypes, including Hantaan (HTNV), Puumala (PUUV), Seoul (SEOV), Dobrava (DOBV), Sin Nombre (SNV) and Andes (ANDV). Additional hantavirus... Agent: Novartis Vaccines And Diagnostics Inc.

20080108052 - Use of ribozymes in the detection of adventitious agents: The present invention provides a method of detecting adventitious agents in a composition comprising a microorganism by using ribozyme-expressing indicator cells, as well as indicator cells useful in such detection.... Agent: Fish & Richardson P.c.

20080108063 - Assay methods: The invention provides an assay method for detection and/or quantification of a plurality of nucleic acid or protein targets in a sample. In the method probes are used to associate a detectable tag sequence with each of the selected targets present in the sample. Probes or primers sufficient to identify... Agent: Townsend And Townsend And Crew, LLP

20080108067 - Cloning of the retinoic acid inducible gene-1 promoter and uses thereof: The present invention relates to the human Retinoic Acid Inducible Gene-1 (hereafter, “RIG-1”) promoter. The present invention provides for the promoter itself which is inducible by interferon, virus infection, retinoic acid and double-stranded RNA. A further embodiment includes expression constructs comprising the RIG-1 promoter operatively linked to a gene of... Agent: Baker Botts L.l.p.

20080108062 - Determination of molecular age by detection of ink4a/arf expression: The presently disclosed subject matter provides methods for determining the molecular age of a tissue. Also provided are methods for employing a molecular age that has been determined for a tissue for assessing the appropriateness of various therapeutic applications for the tissue or a subject comprising the tissue.... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20080108068 - Device and method for multiple analyte detection: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid... Agent: Kilyk & Bowersox, P.l.l.c.

20080108061 - Method for detecting cancer and a method for suppressing cancer: An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating... Agent: Birch Stewart Kolasch & Birch

20080108056 - Method of detecting the expression of aspergillus gene: The present invention provides a method of detecting the expression of a koji mold gene, and a DNA for specifically assaying the fermentation conditions for a koji mold. Specifically, the DNA for specifically assaying the fermentation conditions for a koji mold of the present invention may be characterized in that... Agent: Foley And Lardner LLP Suite 500

20080108059 - Method of measuring heterogeneous nuclear ribonucleoprotein b1 (hnrnp b1) mrna: A method for assaying heterogeneous nuclear ribonucleoprotein B1 (hnRNP B1) mRNA present in a sample, the method comprising a step of using a first primer homologous to at least a portion downstream from the 5′-end of a specified nucleotlde sequence of the RNA and a second primer complementary to at... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080108058 - Methods for diagnosing systemic lupus erythematosus: The invention relates to methods and materials involved in diagnosing SLE. More particularly, the invention relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, the invention provides nucleic acid arrays that can be used to diagnose... Agent: Fish & Richardson P.c.

20080108066 - Methods of identifying compounds that modulate il-4 receptor mediated ige synthesis utilizing a clld8 protein: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and... Agent: Bozicevic, Field & Francis LLP

20080108064 - Peptide nucleic acid probes for analysis of certain staphlococcus species: The present invention relates to peptide nucleic acid (PNA) probes, PNA probe sets and methods for the analysis of certain Staphylococcus species optionally present in a sample. The invention further relates to diagnostic kits comprising such PNA probes or PNA probe sets.... Agent: Edwards Angell Palmer & Dodge LLP

20080108060 - Polynucleotides for the detection of staphylococcus aureus: Polynucleotide primers and probes for the specific amplification and detection of S. aureus in samples are provided. The polynucleotide primers and probes are targeted to the S. aureus gene and are capable of detecting a wide range of S. aureus strains. The primers and probes can be used in real... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080108065 - Systems and diagnostic methods for breast cancer using mmp-1 markers: The present disclosure relates to methods of diagnosing cancer and pre-cancerous conditions in human breast. The disclosure further relates to methods of prognosticating the likely success of clinical treatments for breast cancer. The disclosure further relates to kits suitable for performing the present methods.... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080108084 - Cancer detection methods and reagents: Sensitive and specific methods are provided for use in detecting the presence of cancer marker proteins in the body fluids of a mammal. Also provided are autoantibodies for use in these methods, and immortalized cells which are a source of the autoantibodies.... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20080108083 - Methods of determining active levels of drugs in fluid samples: Methods for determining the presence and level of active drugs in fluid samples are provided. Advantageously, entire families or classes of drugs can be tested for in one test by identifying the enzyme or receptor upon which members of that drug family act and measuring enzyme activity levels or binding... Agent: Hovey, Williams, Timmons & Collins

20080108090 - Methods of identifying small molecules for renewal, survival and migration of cardiac progenitors: The present invention relates to a small molecule high-throughput screening assay consisting of detectably labeled cardiac progenitor cells. The invention also describes a method of identifying small molecules from the high-throughput assay affecting cardiogenesis and/or modulating cardiac progenitor cell development. Also described are methods of stimulating maturation of cardiac progenitor... Agent: Dla Piper Us LLP

20080108094 - Determination of apoptotic products in tumor patients undergoing therapy: The present invention concerns a method for the determination of apoptotic products in samples taken from patients in which apoptosis is induced as a result of disease or therapy, which is characterized in that the concentration of the apoptotic products in samples taken from patients is correlated with the effectiveness... Agent: Barnes & Thornburg LLP (roche)

20080108095 - Microchip and method for detecting molecules and molecular interactions: A microchip with flow-through inlet (104) and outlet (106) channels and test channels (108). The test channels (108) are in fluid communication with the inlet (104) and outlet (106) channels, through inlets (114) and outlets (116) respectively. Each test channel (108) has one test site therein for detection of specific... Agent: Dinsmore & Shohl LLP

20080108097 - Method for producing complex of biotin-labeled cypridina (cypridina noctiluca) luciferase with streptoavidin and method for stabilizing the same: The present invention relates to a method for producing Cypridina luciferase labeled with hydrophilic biotin, characterized in that a biotin reagent containing a polyalkylene glycol structure as a spacer is reacted with Cypridina luciferase, and biotin-labeled Cypridina luciferase wherein a sugar chain in Cypridina luciferase has been biotinylated.... Agent: Knobbe Martens Olson & Bear LLP

20080108101 - Novel classification method of blood cells and tailor-made therapy and prevention based thereupon: A diagnostic technology to provide more efficient treatment for diagnosis of diseases such as leukemia, is provided according to the present invention. The present invention provides a method for identifying a stage of differentiation-maturation of a cell comprising the steps of: A) measuring an expression level of at least one... Agent: Seed Intellectual Property Law Group Pllc

20080108045 - Use of a human amniotic membrane composition for prophylaxis and treatment of diseases and conditions of the eye and skin: A method of preparing an amniotic membrane extract including the steps of obtaining a healthy amniotic membrane from a pregnant mammal, such as a pig, cow, horse or human, homogenizing the membrane to obtain a homogenate solution, freezing the homogenate solution, and lyophilizing the frozen homogenate solution to dryness is... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20080108047 - Method for separating cells: The present invention is related to a method for separating a first population of cells from a second population of cells in a sample by discontinuous density gradient separation using dense particles to target the first population of cells and a density separation medium (DSM) that is at least about... Agent: Bereskin And Parr

20080108046 - Method of sorting cells: A method of sorting cells, particularly, but not exclusively, sperm cells, is described. The method comprises the use of a surface decontamination medium to strip the cells of any extra-cellular surface contamination and to then subject to stripped cells to a charge based on separation.... Agent: Bozicevic, Field & Francis LLP

20080108048 - Model predictive control of fermentation temperature in biofuel production: System and method for controlling temperature of a batch fermenter in a biofuel production process. A nonlinear predictive integrating temperature model for a batch fermentation process is provided that is a function of fermenter level. An objective for the batch fermentation process specifying a target fermenter temperature for the batch... Agent: Jeffrey C. Hood Meyertons Hood Kivlin Kowert & Goetzel Pc

20080108049 - Chimeric protein and its use in electron transfer methods: A chimeric protein comprises a redox catalytic domain from one source and an electron transfer domain from a different source. The protein is used in a method in which a substrate for the redox catalytic domain is acted on, electrons are transferred between the redox catalytic domain and the electron... Agent: Sughrue Mion, Pllc

20080108053 - Compositions and methods for purifying and crystallizing molecules of interest: A composition-of-matter is provided. The composition comprising at least one antibody binding moiety capable of binding an antibody-labeled target molecule, cell or virus of interest, said at least one antibody binding moiety being attached to at least one coordinating moiety selected capable of directing the composition-of-matter to form a non-covalent... Agent: Martin D. Moynihan Prtsi, Inc.

20080108054 - Detecting early hiv infection in genital tract cells and secretions: Provided are methods of diagnosing HIV in a woman. Also provided are methods of diagnosing HIV in an HIV-seronegative woman. Additionally provided are methods of determining whether to recommend that a woman should undergo anti-HIV therapy. The methods comprise detecting HIV in a sample of genital tract cells and/or genital... Agent: Amster, Rothstein & Ebenstein LLP

20080108055 - Method for detecting west nile virus nucleic acids in the 3' non-coding region: Compositions, methods and kits for detecting flavivirus nucleic acids. Particularly described are methods for detecting West Nile virus nucleic acids in the 3′ non-coding region.... Agent: Gen Probe Incorporated

20080108057 - Allelic imbalance in the diagnosis and prognosis of cancer: Methods for assessing the extent of allelic imbalance in a genomic nucleic acid sample. Methods for diagnosing cancer and determining the prognosis of a patient with cancer, including breast or prostate cancer, by assessing the extent of allelic imbalance in a genomic nucleic acid sample.... Agent: Mueting, Raasch & Gebhardt, P.a.

20080108069 - Forensic identification: The invention provides allelic ladder mixtures and individual alleles suitable for use in such mixtures. The allelic ladder mixtures give improved identification and distinguishing capabilities, particularly suitable in forensic investigations.... Agent: Workman Nydegger

20080108079 - Genes associated with copd: A method of screening a small molecule compound for use in treating COPD, comprising screening a test compound against a target selected from the group consisting of the gene products encoded by CELSR3, CHRNA5-THRU-CHRNB4, GPR55, LGR8, PMPCB, SENP1, UCHL1, UQCRC1, BRD2, CCK, HTR6, KCNK3, MBTPS2, NCOA6, PRSS7, SMO, THRA, or... Agent: Glaxosmithkline Corporate Intellectual Property

20080108078 - Genes associated with migraine: A method of screening a small molecule compound for use in treating Migraine, comprising screening a test compound against a target selected from the group consisting of the gene products encoded by APOE, GNAL, NEDD4L, PDIP, TPCN1, TRPM8, ADRA1B, P2RX4, TAAR2, TAAR3, USP11, CHRNA5, RAB5A, DPP8, F2RL1, FZD5, PTGER1, SPI,... Agent: Glaxosmithkline Corporate Intellectual Property

20080108080 - Genes associated with obesity: A method of screening a small molecule compound for use in treating obesity, comprising screening a test compound against a target selected from the group consisting of the gene products encoded by IRS1, IL12A, ADAMTS7, APG4C, CITED1, GGTLA1, PKD1, TSC2, APG4B, CST7, CXCL5, GPR75, CAPN9, DPYS, F13A1, HFE, GPR173, A2M,... Agent: Glaxosmithkline Corporate Intellectual Property

20080108077 - Genes associated with rheumatoid arthritis: A method of screening a small molecule compound for use in treating rheumatoid arthritis, comprising screening a test compound against a target selected from the group consisting of the gene products encoded by ACHE, ADAMTS16, AGER, BAT3, BRD2, C2, BF, C4A-THRU-TNXB, C6ORF21, LY6G6D, CACNA1D, CCR4, CLIC1, DNM1, EDG1, FAS, HLA-DQB1,... Agent: Glaxosmithkline Corporate Intellectual Property

20080108076 - Genes associated with unipolar depression: A method of screening a small molecule compound for use in treating unipolar depression, comprising screening a test compound against a target selected from the group consisting of the gene products encoded by ADCYAP1R1, HMGB1, MIP, NIPSNAP3A, SRC, WFS1, CLIC6, GABRR3, KDR, PKD1L1, ADARB2, MAP3K1, PPARGC1A, DRD3, PTHR1, BF, CART,... Agent: Glaxosmithkline Corporate Intellectual Property

20080108081 - Genetic polymorphisms associated with coronary stenosis, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with coronary stenosis. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods... Agent: Celera, An Applera Business Unit

20080108075 - Kits and methods for assessing oxidative stress: The invention relates to kits and methods for assessing the susceptibility of a human to oxidative stress or damage. The methods involve assessing occurrence in the human's genome of one or more polymorphisms (e.g., single nucleotide polymorphisms) that occur in one or more genes associated with oxidative stress and that... Agent: Thompson Hine L.l.p. Intellectual Property Group

20080108072 - Maize event dp-098140-6 and compositions and methods for the identification and/or detection thereof: Compositions and methods related to transgenic glyphosate/ALS inhibitor-tolerant maize plants are provided. Specifically, the present invention provides maize plants having a DP-098140-6 event which imparts tolerance to glyphosate and at least one ALS-inhibiting herbicide. The maize plant harboring the DP-098140-6 event at the recited chromosomal location comprises genomic/transgene junctions having... Agent: Alston & Bird LLP

20080108074 - Methods and compositions for efficient nucleic acid sequencing: Disclosed are novel methods and compositions for rapid and highly efficient nucleic acid sequencing based upon hybridization with two sets of small oligonucleotide probes of known sequences. Extremely large nucleic acid molecules, including chromosomes and non-amplified RNA, may be sequenced without prior cloning or subcloning steps. The methods of the... Agent: Marshall, Gerstein & Borun LLP

20080108071 - Methods and systems to determine fetal sex and detect fetal abnormalities: Non-invasive methods for determining the sex of a human fetus and predicting other genetic abnormalities are disclosed. The methods include screening a maternal sample for biomarkers known to be associated with risk of genetic abnormalities; removing all or substantially all nucleated and anucleated cell populations from the maternal sample to... Agent: Baker Botts, LLP

20080108073 - Methods of analysis of methylation: Methods for determining the methylation status of a plurality of cytosines are disclosed. In some aspects genomic DNA target sequences containing CpGs are targeted for analysis by multiplex amplification using target specific probes that can be specifically degraded prior to amplification. The targets may be modified with bisulfite prior to... Agent: Affymetrix, Inc Attn: Chief Ip Counsel, Legal Dept.

20080108070 - Methods, compositions, and kits for the detection and monitoring of colon cancer: Methods and compositions for the diagnosis and monitoring of colon cancer are disclosed.... Agent: Seed Intellectual Property Law Group Pllc

20080108082 - Polymerase enzymes and reagents for enhanced nucleic acid sequencing: Compositions that include DNA polymerases having increased residence times for nucleotide analogues, particularly modified recombinant Φ29-type DNA polymerases with such increased residence times, are provided. Methods of making the polymerases and of using the polymerases in sequencing and DNA amplification are also provided. Compositions including α-thiophosphate nucleotide analogues with four... Agent: Quine Intellectual Property Law Group, P.c.

20080108085 - Method and detection of the presence of prions protein: The invention relates to methods for determining the presence of prions in a tissue/organ or fluid therefrom; said method comprising the steps of: contacting the tissue/organ with one or more devices, wherein said devices are capable of binding prions; removing said devices from contact with said tissue/organ; determining if said... Agent: Marshall, Gerstein & Borun LLP

20080108087 - Method of processing and testing powdered samples using immunochromatographic strip tests: A method and kit for processing and testing powdered samples are provided herein. The powdered sample is combined with a fluid to produce a slurry or liquid suspension, and the slurry is contacted with an immunochromatographic test strip containing detectable reagents that are immunoreactive with an analyte to be detected... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20080108086 - Parathyroid hormone antagonists and uses thereof: The present invention relates to parathyroid hormone (PTH) antagonists. More particularly, the present invention provides for pharmaceutical compositions, kits and combinations comprising the PTH antagonist. The present invention also provides for methods for preventing, treating or delaying a disease or disorder associated with excessive bone mineral, e.g., calcium, loss or... Agent: Morrison & Foerster LLP

20080108088 - T2r, a novel family of taste receptors: The invention provides nucleic acid and amino acid sequences for a novel family of taste transduction G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste transduction G-protein coupled receptors.... Agent: Townsend And Townsend And Crew, LLP

20080108092 - Monoclonal antibody for nkx3.1 and method for detecting same: The present invention pertains to a monoclonal antibody, or fragment thereof, having an antigen-binding specific region for NKX3.1 and to a hybridoma cell line for producing the monoclonal antibody. The present invention also pertains to a method for detecting the presence of NKX3.1 in a sample. The method comprises (a)... Agent: Licata & Tyrrell P.c.

20080108093 - Novel 27875, 22025, 27420, 17906, 16319, 55092 and 10218 molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced,... Agent: Millennium Pharmaceuticals, Inc.

20080108091 - Proteomic patterns of cancer prognostic and predictive signatures: The invention provides method for predicting whether a cancer patient will respond to a therapy. Methods of the invention may involve examining protein from a cell of the cancer patient by determining the binding of a panel of antibodies to the protein. Methods of the invention may be used to... Agent: Fulbright & Jaworski L.l.p.

20080108089 - Methods for predicting pregnancy outcome in a subject by hcg assay: The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin... Agent: John P. White Cooper & Dunham LLP

20080108096 - Analytical method: The instant invention describes an analytical assay to accurately measure an analyte in the presence of an interfering substance.... Agent: Heller Ehrman LLP

20080108098 - Novel germinal kinase proteins, compositions and methods of use: The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins, and proteins so encoded which are capable of modulating proliferation, survival, morphology, and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation,... Agent: Klarquist Sparkman, LLP

20080108100 - Method of determining lymph node metastasis: A method of determining lymph node metastasis in a subject is disclosed, comprising determining at least one structural or functional parameter of a lymph node cell of a lymph node tissue of the subject, wherein an alteration in the at least one structural or functional parameter with respect to a... Agent: Martin D. Moynihan Prtsi, Inc.

20080108099 - Methods for diagnosing chronic diarrhea: Methods for diagnosing chronic diarrhea and other gastrointestinal conditions are disclosed. In the methods, a sample of gastrointestinal secretions may be obtained from a control group; or a group of people who have been diagnosed with either healthy gastrointestinal tracts or a gastrointestinal condition, like chronic diarrhea. The samples from... Agent: Kirton And Mcconkie

20080108102 - Fluorescent substrates for neurotransmitter transporters: The invention is based on the finding that IDT307 and analogs thereof are fluorescent substrates transported by several neurotransmitter transporters. Provided are methods for the analysis of neurotransmitter transport and binding using IDT307 and its analogs. The invention also provides rapid methods for screening for modulators of neurotransmitter transport.... Agent: Fulbright & Jaworski L.l.p.

20080108103 - Methods of discriminating cancer/atypical cell and particle agglomerate, and cytoanalyzer: Highly accurate and easy discrimination of cancer/atypical cells is achieved. A cancer/atypical cell discrimination method comprises: measuring a plurality of cells by a flow cytometer; acquiring a scattered light signal for each of the cells; calculating at least one characteristic parameter by analyzing the waveform of the scattered light signal;... Agent: Brinks Hofer Gilson & Lione

20080108104 - Identification of bacterial species and subspecies using lipids: The use of free, extractable lipids found in bacteria for identification of bacterial species and subspecies is described. Bacteria have been found to differ sufficiently in their extracted lipid compositions to effect identification using thin layer chromatographic techniques. Burkholderia pseudomallei, Burkholderia thailandensis, and Burkholderia mallei have been distinguished in this... Agent: Cochran Freund & Young Llc

20080108107 - Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits: Composition of matter comprising the causative agent of Mystery Swine Disease, Lelystad Agent, in a live, attenuated, dead, or recombinant form, or a part or component of it. Vaccine compositions and diagnostic kits based thereon. Recombinant nucleic acid comprising a Lelystad Agent-specific nucleotide sequence. Peptides comprising a Lelystad Agent-specific amino... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20080108105 - Fungal transcriptional activators useful in methods for producing a polypeptide: The present invention relates to functional cDNA and genomic sequences encoding PrtT proteins, which have transcriptional activity on a protease promoter, to PrtT proteins and to their use. The invention further relates to two distinct types of filamentous fungal cells. Filamentous fungal cells are transformed to over-express these PrtT proteins:... Agent: Nixon & Vanderhye, Pc

20080108106 - Glycolysis-inhibiting substances in cell culture: An improved system for large scale production of proteins and/or polypeptides in cell culture is provided. In accordance with the present invention, cells expressing the protein or polypeptide of interest are grown in media that comprise a glycolysis-inhibiting substance. Additionally and/or alternatively, cells expressing the protein or polypeptide of interest... Agent: Choate, Hall & Stewart LLP/wyeth

20080108108 - Novel p. pastoris pastoris promoters, and the use thereof to direct expression of proteins in yeast, preferably using a haploid mating strategy: Novel promoters which are derived from P. pastoris pastoris which are inducible or repressible under specific growth conditions are provided. These promoters are useful for regulating the expression of a desired structural gene, e.g., a mammalian polypeptide. Particularly preferred is the use of these novel promoters to regulate gene expression... Agent: Hunton & Williams LLP Intellectual Property Department

20080108109 - Biosynthesis of ta antibiotic: A method of producing an antibiotic TA comprising (i) expressing in a host cell an exogenous polynucleotide sequence encoding at least one polypeptide selected from the group consisting of SEQ ID NOs: 1 and 3-19; and (ii) culturing the host cell under conditions suitable for synthesis of the antibiotic TA,... Agent: Martin D. Moynihan Prtsi, Inc.

20080108110 - Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same: The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, in order to create a variety of glycosaminoglycan oligosaccharides having a natural or chimeric or hybrid sugar structure with a targeted size... Agent: Dunlap Codding & Rogers, P.c.

20080108111 - Novel polyphosphate: amp phosphotransferase: (wherein NMP represents nucleoside monophosphate, NDP represents nucleoside diphosphate, dNMP represents deoxynucleoside monophosphate, dNDP represents deoxynucleoside diphosphate, n represents degree of polymerization of the polyphosphate which is an integer of up to 100); (B) substrate specificity: specific to AMP, GMP, IMP, dAMP, and dGMP, also acting with CMP, UMP, dCMP,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080108112 - Apparatus and methods for parallel processing of micro-volume liquid reactions: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays... Agent: Edwards Angell Palmer & Dodge LLP

20080108113 - Methods for the enrichment of trehalose using alumosilicates: The invention relates to a process for enriching trehalose from solutions, in which the enrichment is performed using an adsorbent, in which the adsorbent is an aluminosilicate. Preferably, the aluminosilicate is a zeolite. The invention further relates to the enrichment and purification of trehalose from fermentation broths, in particular as... Agent: Lahive & Cockfield, LLP

20080108114 - Glucan preparations: A method for producing particulate β-glucan utilizes surfactant extraction to reduce lipid impurities that decompose to volatile organic compounds (VOCs). The resulting particulate β-glucan is essentially free of VOCs.... Agent: Biopolymer Engineering , Inc. Dba Biothera , Inc

20080108115 - Enhanced production of taxol and taxanes by cell cultures of taxus species: This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g., brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e., media composition and operating modes) have been... Agent: Hunton & Williams LLP Intellectual Property Department

20080108116 - Stereoselective preparation of gamma-lactones: Method for stereoselectively preparing a (R) or (S) gamma-lactone consists in microbially biosynthesising gamma-lactone, wherein the biosynthesis is carried out from a substrate selected from C5 to C20 fatty acids with the aid of a strain selected from those enabling a stereoselective hydroxylation in C4 of the substrate, in particular... Agent: Young & Thompson

20080108117 - Method for producing an optically active 2-methyl-alkane-1-ol from the corresponding 2-methylalk-2-en-1-al, comprising carbonyl-selective reduction, enantioselective hydration and lipase-catalyzed stereoselective acylation in order to enrich the desired: t

20080108118 - Production of a fermentation product from a composite material: A method of converting a composite material derived from municipal solid waste into alcohol is provided.... Agent: Waddey & Patterson, P.c.

20080108119 - Method, chip, device and system for extraction of biological materials: The present invention relates to a method, a chip, a device and a system for extraction of biological material form biological cells. The invention involves exposing the biological particles to an alternating electric field in a sample chamber and may also involve subsequent analysis of the biological material after the... Agent: Knobbe Martens Olson & Bear LLP

20080108120 - Centrifugal force-based microfluidic device for nucleic acid extraction and microfluidic system including the microfluidic device: A centrifugal force-based microfluidic device for nucleic acid extraction and a microfluidic system are provided. The microfluidic device includes a body of revolution; a microfluidic structure disposed in the body of revolution, the microfluidic structure including a plurality of chambers, channels connecting the chambers, and valves disposed in the channels... Agent: Sughrue Mion, Pllc

20080108121 - Method of arranging cells and electrode array applied thereto: A method of arranging cells comprises: (a) applying a voltage to two electrodes so as to allow a plurality of cells suspended in a dielectrophoresis-manipulating buffer (DEP-manipulating buffer) to be driven to be arranged into a pattern; (b) replacing the DEP-manipulating buffer with a solution comprising calcium ion and magnesium... Agent: Rabin & Berdo, Pc

20080108123 - Magnetic substance-biosubstance complex structure, peptide fragment capable of linking to magnetic substance and gene therefor, and process for producing the complex structure: A magnetic substance-biosubstance complex structure comprises a magnetic substance-containing carrier and a biosubstance immobilized on the carrier, the biosubstance being immobilized through a spacer comprising an amino acid sequence on a surface of the carrier.... Agent: Fitzpatrick Cella Harper & Scinto

20080108122 - Microchemical nanofactories: Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining a reactor and a separator. Such apparatuses, or portions thereof, generally have dimensions ranging from about 1 micrometer to about 100 micrometers. To implement... Agent: Klarquist Sparkman, LLP

20080108124 - Polymerase inhibitor and method of using same: The present invention provides nucleic acid based polymerase inhibitors and methods for reducing non-specific polymerase extension and amplification in nucleic acid amplification reactions. The polymerase inhibitors provide a double stranded nucleic acid portion that is recognized by a polymerase enzyme as a template for extension but is incapable of being... Agent: Foley & Lardner LLP

20080108125 - Expression of granular starch hydrolyzing enzyme in trichoderma: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.... Agent: Lynn Marcus-wyner Genencor International, Inc.

20080108126 - Pullulanase variants with increased productivity: The invention relates to novel variants of the enzymatic peptide pullulanase, the gene sequences encoding said novel peptides, expression vectors comprising those gene sequences as well as organisms expressing the novel pullulanase variants. The novel pullulanase variants of the present invention were made empirically by the use of codon-optimization procedures,... Agent: Jennifer A. Haynes, Ph.d. Genencor International, Inc.

20080108127 - Plant activation of insect toxin: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20080108128 - Resonance energy transfer assay system for multi-component detection: The present invention relates to a system for detecting molecular associations. In particular, the present invention relates to a multi-component detection system comprising: i). a first agent comprising a first interacting group coupled directly or indirectly to a first tag, which first tag emits light of a first wavelength upon... Agent: Fish & Richardson P.c.

20080108129 - Method for obtaining modified proteins and viruses with intact native binding site: Methods for obtaining modified proteins or virus with an intact native binding site and decreased antigenicity and modified proteins or virus obtainable by said methods are provided. The methods of protein or virus modification comprise masking with non-immunogenic molecules the protein or the virus surface, except for the protein or... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080108130 - Sensor device: A sensor device enabling quick and uniform dissolution of reagents is provided. The sensor device includes a holding member having a liquid sample holding section for holding a liquid sample containing an analyte. A reagent that reacts or interacts with the analyte in the liquid sample and an effervescent agent... Agent: Mcdermott Will & Emery LLP

20080108131 - Detection of biomolecules using porous biosensors and raman spectroscopy: The invention provides methods used to analyze the contents of a biological sample, such as blood serum, with cascade Raman sensing. A fluorescence producing nanoporous biosensor having probes that bind specifically to known analytes is contacted with a biological sample and one or more bound complexes coupled to the porous... Agent: Intel Corporation C/o Darby & Darby P.c.

20080108132 - Kit for immobilizing organic substance, organic substance-immobilized structure, and manufacturing methods therefor: To provide an organic substance-immobilized structure employing a novel immobilizing technique and a manufacturing method thereof using the novel immobilizing technique, where, when an organic substance, particularly a biological substance is immobilized on the surface of a substrate, the organic substance, particularly the biological substance can be stably immobilized on... Agent: Fitzpatrick Cella Harper & Scinto

20080108133 - Adenocarcinoma specific antibody sam-6, and uses thereof: A purified polypeptide that binds to neoplastic cells, which may be an antibody, is produced by the hybridoma SAM-6, a method for its production and use in the treatment and diagnosis of neoplasms.... Agent: Pillsbury Winthrop Shaw Pittman LLP

20080108134 - Bioengineered tissue constructs and methods for producing and using thereof: Cultured tissue constructs comprising cultured cells and endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. Some tissue constructs of the invention are comprised of multiple cell layers or more than one cell type. The tissue constructs of the invention have... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20080108135 - Internalizing erbb2 antibodies: This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.... Agent: Quine Intellectual Property Law Group, P.c.

20080108136 - Method and apparatus of cultivating multipotent stem cell: In a method of cultivating multipotent stem cells, the multipotent stem cells are cultivated while suppressing differentiation of the multipotent stem cells sealed in a first cultivating container. Then, the cultivated multipotent stem cells are cultivated while applying a force to the cultivated multipotent stem cells sealed in a second... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20080108137 - Dispersion devices for aggregates: The present invention encompasses a flow-through dispersion device for the dispersion of cell aggregates, the device comprising a first or upstream inlet obstacle and a second or downstream outlet obstacle, each obstacle having at least one traversing hole wherein no two holes align. Between the two obstacles is a turbulence... Agent: Judy Jarecki-black Ph.d., J.d.

20080108138 - Bioactive compositions and their use in cell patterning: The present application relates to a bioactive composition comprising a arcuoid substrate and a polymeric film deposited on the surface of the substrate. The bioactive composition can control the patterning of a cell. The present application also relates to a method of modulating the patterning of a cell. This particular... Agent: Ogilvy Renault LLP

20080108139 - Composition of matter comprising primary nucleic acid component: The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics... Agent: Cheryl H Agris Phd

20080108140 - Ceacam1 mediated protective immunity: The presently described technology relates to the modulation of specific immune responses to create a protective immunity in the treatment of autoimmune diseases and diseases requiring the transplantation of tissue. In particular, the present technology relates to the suppression of immune responses in a targeted fashion, by increasing the functional... Agent: Mcandrews Held & Malloy, Ltd

20080102439 - Biological tissue for surgical implantation: A method of treating a biological tissue that enables dry storage of said tissue is disclosed. In one embodiment, the method comprises contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C1-C3 alcohol and removing a portion of the treatment solution from the solution-treated... Agent: Edwards Lifesciences Corporation

20080102438 - Novel technique to fabricate molded structures having a patterned porosity: The present invention relates to a process for fabricating molded structures having a radially organized pore structure. The molded structures are formed using a spinning-induced sedimentation technique such that sedimentation of a multi-component liquid suspension produces the internal geometry and porosity of the structure. The porous molded structures of the... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080102441 - Analyte sensors and methods: Methods of determining analyte concentration. The methods use a fraction of the predicted total charge, from analyte electrolysis, instead of using time, for determination of a data collection endpoint. The total charge is then extrapolated from the data collection endpoint. The analyte concentration is determined from the total charge.... Agent: Merchant & Gould PC

20080102440 - Biological sensor: A biological sensor, especially a barosensor, which can be operated using a neuronal network is described. Neuronal cultures suitable for use in such a sensor are also described.... Agent: Nixon & Vanderhye, PC

20080102443 - Column cartridge, column cartridges assembly, analyzer, and analyzing method: The present invention is to present a column cartridge that enables the obtainment of a plurality of analysis objects from a single sample easily. The column cartridge comprises: a first liquid sample receiving part having an opening for receiving a liquid sample; a carrier for isolating a target substance from... Agent: Sughrue Mion, PLLC

20080102442 - Food sample collector: The present invention provides novel methods and devices for detection of pathogens or other microbes in an analyzed sample (e.g., food, industrial, pharmaceutical, botanical, environmental etc., sample). The inventive methods and devices provide for increasing the power of detection for pathogens on food surfaces, comprising increasing the number of independent,... Agent: Davis Wright Tremaine, LLP/seattle

20080102451 - Companion diagnostic assays for endothelin receptor antagonists: Methods for identifying cancer patients eligible to receive endothelin receptor antagonist therapy and for monitoring patient response to endothelin receptor antagonist therapy comprise assessment of the expression levels of at least one of PAI-1, uPA, TGFbeta2, IL-6, IL-8 and OPG in a patient tissue sample. The methods of the invention... Agent: Vysis, Inc Patent Department

20080102456 - Compositions and methods for obesity screening using polymorphisms in npy2r: Methods and constructs are provided that are predictive of a subject's susceptibility to developing a metabolic disorder, such as obesity. The disclosed naturally-occurring SNPs located upstream of the NPY2R gene can be used as targets for the design of diagnostic reagents and the development of therapeutic agents, as well as... Agent: Nutter Mcclennen & Fish LLP

20080102452 - Control nucleic acid constructs for use in analysis of methylation status: In some embodiments, control nucleic acid constructs useful as spiking reagents are provided which comprise a nucleic acid vector having an insert comprising a control nucleic acid molecule. In some embodiments, the insert contains at least one methyltransferase recognition site, such as a CpG dinucleotide. In some embodiments, the insert... Agent: Agilent Technologies Inc.

20080102450 - Detecting dna methylation patterns in genomic dna using bisulfite-catalyzed transamination of cpgs: Methods and compositions for identifying or detecting methylation patterns in a target nucleic acid are described. Cytosine residues in regions of interest are transaminated and labeled. The labeled residues are then hybridized to a microarray containing probes complementary to the region of interest, to identify the amount of methylation in... Agent: Agilent Technologies Inc.

20080102461 - Device and method for multiple analyte detection: The invention is directed to a method and device for simultaneously testing a sample for the presence, presence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, device for detecting or quantitating a plurality of different analytes in a liquid sample.... Agent: Kilyk & Bowersox, P.l.l.c.

20080102462 - Device and method for multiple analyte detection: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid... Agent: Kilyk & Bowersox, P.l.l.c.

20080102455 - Method of detecting aneuploidy: The present invention provides a method for detecting aneuploidy in a subject. This method has applications for the detection of aneuploidy in single cells, embryos and complete organisms. The present invention has particular application for the detection of aneuploidy in human and other animal embryos generated by in-vitro fertilization. Pre-implantation... Agent: Knobbe Martens Olson & Bear LLP

20080102459 - Method of screening antiobesity agents: The present invention relates to a method of screening for an antiobesity agent, an antidiabetic agent, and/or a hypolipidemic agent, comprising the step of analyzing whether or not a substance to be tested promotes an expression and/or a function of an angiopoietin-related growth factor. The present invention relates to a... Agent: Sughrue Mion, PLLC

20080102449 - Methods and compositions for detecting and identifying species of candida: Methods and compositions useful in the detection and identification of species of Candida are disclosed. These species include Candida albicans, Candida glabrata, Candida parapsilosis, and Candida tropicalis, each of which is a causative agent for vaginal candidiasis. The compositions of the invention are combinations of oligonucleotides. These oligonucleotides include pairs... Agent: Medical Diagnostic Laboratories LLC

20080102453 - Methods and systems and analysis of cgh data: Methods, systems and computer readable media for analysis of comparative genomic hybridization data analysis, including creating a centralization curve from log ratio data values for DNA copy numbers of a genome of a test sample relative to a genome of a reference sample, wherein the reference sample has a known... Agent: Agilent Technologies Inc.

20080102448 - Novel vector and utilization of the same: A vector characterized by having two restriction recognition sequences different in nucleotide sequence both of which are recognized by a first restriction enzyme, one of the restriction recognition sequences comprising a part of a restriction recognition sequence recognized by a second restriction enzyme that is different from the first restriction... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080102458 - Polymorphic loci that differentiate escherichia coli 0157:h7 from other strains: The present invention relates generally to the field of microbiology and food sciences. More particularly, the inventor has discovered several polynucleotide sequences encoding the gnd gene and corresponding 6-phosphogluconate dehydrogenase (6-PGD) proteins from different strains of Escherichia Coli and polymorphic sequences therein. Novel biotechnological tools, diagnostics, and food screening techniques... Agent: Seed Intellectual Property Law Group PLLC

20080102454 - Reducing size of analytes in rna sample: The invention relates to methods for treating samples of RNA. In an embodiment the method includes contacting the sample of RNA with a set of oligodeoxynucleotides to provide a DNA/RNA duplex. The method includes contacting the DNA/RNA duplex with an enzyme having a DNA:RNA nuclease activity to provide a digested... Agent: Agilent Technologies Inc.

20080102460 - System and method for quantifying the sequence specificity of nucleotide binding factors: Systems and methods for determining free energy parameters for predicting binding affinities of nucleotide sequences are provided. The disclosed subject matter obtains phenotypic measurements for nucleotide sequences (for example a DNA sequence or RNA sequence), links the phenotypic measurements to the nucleotide sequences to obtain linked pairs of phenotypic measurements... Agent: Baker Botts L.L.P.

20080102469 - System for analysis of gene sequence: A conventional large-scale parallel pyrosequencing apparatus has the disadvantage that throughput decreases because much time and a large number of procedures are required for introduction of measurement beads, and analysis accuracy is deteriorated due to a reduction in accuracy of reagent replacement. There is provided an apparatus, wherein the apparatus... Agent: Antonelli, Terry, Stout & Kraus, LLP

20080102457 - Target protein and target gene in drug designing and screening method: The present invention provides target proteins and target genes for bioactive substances such as drugs, and means that enable the development of novel bioactive substances using the same. To be specific, the present invention provides target proteins and target genes for bioactive substances; screening methods for substances capable of regulating... Agent: Leydig Voit & Mayer, Ltd

20080102474 - Detection of a therapeutic antibody in an experimental animal: The present invention relates to the field of therapeutic antibodies. It especially relates to the study of therapeutic antibodies in an experimental animal. The present invention discloses a method of detecting a therapeutic antibody in a sample obtained from an experimental animal comprising the steps of a) providing the sample... Agent: Hoffmann-la Roche Inc. Patent Law Department

20080102473 - Method and system to improve contrast in lateral flow assay: A lateral flow assay includes one or more optically-reactive test regions that are examined using light propagating at a wavelength that matches or nearly matches an absorption wavelength associated with each optically-reactive test region. The presence or absence of a color or absorption in each optically-reactive test region may be... Agent: Kathy Manke Avago Technologies Limited

20080102476 - Analyzing histamine h4 receptor-mediated effects in whole blood: Assay methods for analyzing whole blood to detect histamine H4 receptor-mediated effects, such as eosinophil shape change, cytoskeletal change, adhesion molecule up-regulation, or calcium flux are described. Such methods are useful in clinical and diagnostic applications.... Agent: Philip S. Johnson Johnson & Johnson

20080102477 - Method for screening an anticancer drug using acetylated bubr1: A method of screening for an anticancer drug comprising treating a cancer cell with candidate compounds and assessing the change in acetylated BubR1 level of the cancer cell is useful for efficiently screening an anticancer drug. An antibody which specifically binds to the 250th amino acid residue, Lys, of BubR1... Agent: Sughrue Mion, PLLC

20080102481 - Assay for cardiac troponin autoantibodies: The invention provides among other things methods and kits based on assaying for cardiac troponin autoantibodies, either in conjunction with an assay for cardiac troponin and/or as an independent indicator of cardiac pathology, such as myocarditis, cardiomyopathy, and/or ischemic heart disease. Assay methods of the invention can be employed among... Agent: Paul D. Yasger Abbott Laboratories

20080102480 - Method and apparatus of enzyme-link immunosorbent assay: An improved method of enzyme-link immunosorbent assay (ELISA) is disclosed, which can be adapted to be implemented by an analytic apparatus having a testing platform and a conducting platform, being arranged separate from the testing platform, and comprises steps of: applying a specific agent upon a reaction zone of the... Agent: Wpat, PC

20080102482 - Apparatus for detecting drugs in a beverage: A test kit for detecting the presence of one or more drugs in a beverage comprising a support having a plurality of detector strips attached thereto. Drugs to be detected are e.g. benzodiazepines, gamma hydroxy butyrate GHB), Ketamines, Ectasy (MDMA), cocaine barbiturates, opiates, cannabis and flunitrazepam (Rohypnol®).... Agent: Sonnenschein Nath & Rosenthal LLP

20080102487 - Method and apparatus for non-invasive rapid fungal specie (mold) identification having hyperspectral imagery: In a method and apparatus for identifying and distinguishing fungal species, a hyperspectral imaging scanner is used to acquire hyperspectral image data for radiation obtained from a sample area in which at least one unknown fungal species is present. A computer compares the acquired hyperspectral image data with spectral signature... Agent: Crowell & Moring LLP Intellectual Property Group

20080102486 - Method for detection of yeast cell wall: Methods are provided for detecting the presence of a yeast cell wall in a food or animal feed suspected of containing the yeast cell wall. The method includes the steps of solubilizing the yeast cell wall, adding a lectin which preferentially binds to a mannose component of the solubilized yeast... Agent: King & Schickli, PLLC

20080102485 - Methods and systems for ensuring the security of grain stores: Aspects include claims, systems, and methods for testing bulk grain stores to identify the presence of contaminants. Such contaminants tested for may include biological, chemical, or radio nuclear material. Another aspect is marking and/or tracking grain stores that have been certified as either being contaminated or safe. Still another aspect... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20080102488 - Microorganism of enterobacteriacae genus haboring genes associated with l-carnitine biosynthesis and method of producing l-carnitine using the microorganism: Provided is a microorganism belonging to the family Enterobacteriaceae including: a polynucleotide encoding N-trimethyllysine hydroxylase activity derived from Neurospora crassa; a polynucelotide encoding 3-hydroxy-6-N-trimethyllysine aldolase activity derived from Neurospora crassa; a polynucleotide encoding γ-trimethylaminoaldehyde dehydrogenase activity derived from Neurospora crassa; and a polynucleotide encoding γ-butyrobetaine hydroxylase activity derived from Neurospora... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080102493 - Isolation of rna and dna from a biological sample: The invention relates to methods of isolating nucleic acids from a sample using a filter device comprising a plurality of membranes. The invention also provides for devices comprising a plurality of membranes and kits suitable for isolating nucleic acids from a sample.... Agent: Millipore Corporation

20080102494 - Dna amplification method: It is intended to provide a DNA amplification method whereby a single-stranded DNA in a desired direction and in a desired region can be conveniently and efficiently prepared. Namely, a DNA amplification method with the use of a DNA as a template which comprises: the first step wherein use is... Agent: Wood, Herron & Evans, LLP

20080102495 - Multi-stage amplification reactions by control of sequence replication times: The present invention provides methods and kits for conducting multiplex nucleic acid amplification reactions by controlling target sequence replication times. In one aspect, such control is exerted by selecting different lengths of target polynucleotides for amplification. In another aspect, control is exerted by providing sequence-specific polymerase inhibitors, such as specific... Agent: Townsend And Townsend And Crew, LLP

20080102496 - Expression of nitrile hydratases in a two-vector expression system: The present invention relates to a novel system for expressing nitrile hydratase. In this system, the nitrile hydratases, which are composed of subunits, are formed such that the respective subunits are located on different plasmids and are expressed simultaneously in E. coli.... Agent: Pillsbury Winthrop Shaw Pittman LLP

20080102444 - Methods and compositions for detecting rhinoviruses: The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based (e.g., DNA based) detection of human rhinovirus (HRV) in a sample. In general, the methods involve detecting a target nucleic acid having a target sequence of a conserved 5′ untranslated region of the HRV genome. The... Agent: Foley & Lardner LLP

20080102447 - Methods for diagnosing chronic fatigue syndrome: Methods are provided for detecting enteroviral antigens in the stomach of patients having symptoms consistent with chronic fatigue syndrome (CFS). The presence of enteroviral viral antigens in the stomach of these patients is then correlated with the patients' symptoms to establish a diagnosis of CFS.... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20080102445 - Nucleic acid amplification controls: The present invention discloses positive control material for nucleic acid amplification based detection of microorganisms in biological samples. The control material comprises purified microorganism that is rendered non-infectious but is amenable to nucleic acid amplification. Also disclosed is a process for making and using the control material.... Agent: Hodgson Russ LLP The Guaranty Building

20080102446 - Nucleic acid amplification controls: The present invention discloses positive control material for nucleic acid amplification based detection of microorganisms in biological samples. The control material comprises purified microorganism that is rendered non-infectious but is amenable to nucleic acid amplification. Also disclosed is a process for making and using the control material.... Agent: Hodgson Russ LLP The Guaranty Building

20080102468 - Compositions and methods for treatment of non-hodgkin's lymphoma: The present invention is directed to compositions of matter useful for the treatment of non-Hodgkin's lymphoma in mammals and to methods of using those compositions for the same.... Agent: Genentech, Inc.

20080102463 - Gene 4: A nucleotide acid sequence is provided encoding a protein having NAALAdase like activity. NALADase activity has been found to be decreased in schizophrenic brain tissue. Its encoded protein can be used to screen for glutamate peptidase modulators.... Agent: Organon Usa, Inc. Patent Department

20080102464 - Method and device to probe a membrane by applying an in-plane electric field: The present invention disposes a membrane, for example, a biological cell membrane including amphiphilic lipids, cholesterol and proteins, between two electrical conductive walls having a height at least as great as the thickness of the membrane. The conductive walls are fabricated on an electrically insulative chip base. Electrical conductors extend... Agent: Pearne & Gordon LLP

20080102466 - Method of generating nested sets of double stranded dna circles: The invention provides a method of generating nested sets of double stranded DNA (dsDNA) circles that may be used as size ladders in nucleic acid separations and as templates in DNA sequencing operations. In one aspect, the invention provides methods for generating nested sets of double stranded DNA circles in... Agent: Stephen C. Macevicz

20080102470 - Methods and substances for isolation and detection of small polynucleotides: A capture probe suitable for use with methods for isolating, labeling or detecting small polynucleotides. A method for isolating a small polynucleotide of interest from a sample comprising hybridizing the small polynucleotide to the capture probe and lengthening the small polynucleotide by primer extension or ligation. A method for detecting... Agent: Sheldon Mak Rose & Anderson PC

20080102467 - Methods to identify patients at risk of developing adverse events during treatment with antidepressant medication: The invention provides a method of screening patients to identify those patients more likely to exhibit an increased risk of treatment-emergent suicidal ideation comprising: (a) obtaining a sample of genetic material from the patients, and (b) assaying the sample for the presence of a genotype in the patients which is... Agent: Leydig, Voit & Mayer, Ltd.

20080102472 - Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same: Oncokinase fusion polypeptides associated with hyperproliferative disorders and the polynucleotides encoding for such fusion polypeptides are provided. The fusion polypeptides have a C-terminal tyrosine kinase domain fused to an N-terminal domain that is not normally fused to the C-terminal tyrosine kinase domain and they possess constitutively activated tyrosine kinase activity.... Agent: Theravance, Inc.

20080102471 - Plant myb transcription factor homologs: This invention relates to an isolated nucleic acid fragment encoding a Myb-related transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the Myb-related transcription factor, in sense or antisense orientation, wherein expression of the chimeric gene results in production of... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080102465 - Pthrp-based prediction and diagnosis of bone disease: The invention provides methods of diagnosing bone disease and/or a susceptibility thereto, in an individual. The method includes screening a biological sample obtained from the individual for one or more genetic indicators of bone disease in said PTHrP gene of the individual, and diagnosing the individual based on a characterization... Agent: Ogilvy Renault LLP

20080102475 - Alternatively spliced isoform of phosphodiesterase 4b (pde4b): The present invention features nucleic acids and polypeptides encoding novel splice variant isoform of phosphodiesterase 4B (PDE4B). The polynucleotide sequence of PDE4Bsv1 is provided by SEQ ID NO: 3. The amino acid sequence of PDE4Bsv1 is provided by SEQ ID NO: 4. The present invention also provides methods for using... Agent: R. Douglas Bradley Merck & Co., Inc.

20080102478 - 3d micro-scale engineered tissue model systems: A polymeric chip having at least one three-dimensional porous scaffold, a microfluidic channel inlet to the porous scaffold, and a microfluidic channel outlet from the porous scaffold. In one embodiment, the polymeric chip has two three-dimensional porous scaffolds: one scaffold comprises liver cells and the other scaffold comprises cancer cells.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20080102479 - Method of diagnosing lawsonia intracellularis: The present invention relates to the field of animal health and in particular to Lawsonia intracellularis. In particular, the invention relates to a method of diagnosing Lawsonia intracellularis infection and a diagnostic test kit using Lawsonia intracellularis-specific antibodies. The invention also relates to the use of the method or test... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20080102483 - Device and direct method for detection of antibiotic-inactivating enzymes: A method for determining whether a microorganism produces an AmpC β-lactamase is disclosed in which a culture of a microorganism suspected of producing a β-lactamase that inactivates a β-lactam-containing antibiotic is admixed with an effective amount of each of i) a β-lactam-containing antibiotic, ii) a β-lactamase inhibitor to which AmpC... Agent: Stinson Morrison Hecker LLP Attn: Patent Group

20080102484 - Dendritic cell transmembrane serine protease: Isolated Dendritic Cell Transmembrane Serine Proteases (DCTSPs), DNAs encoding such DCTSPs, and pharmaceutical and/or diagnostic compositions made therefrom, are disclosed. The isolated DCTSPs can be used to hydrolyze peptide bonds. The DCTSPs are also useful in screening for inhibitors or agonists thereof.... Agent: Immunex Corporation Law Department

20080102491 - Bacterial host cell for the direct expression of peptides: Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth... Agent: Ostrolenk Faber Gerb & Soffen

20080102489 - Dna molecules encoding ligand gated ion channels from dermacentor variabilis: The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Dermacentor variabilis ligand gated ion channel proteins. The present invention also relates to recombinant vectors and recombinant hosts which contain a DNA fragment encoding D. variabilis LGIC/GluCl channels, substantially purified forms of associated D. variabilis channel... Agent: Judy Jarecki-black, Ph.d., J.d. Merial Ltd.

20080102490 - Interferon-like protein zcyto21: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.... Agent: Zymogenetics, Inc. Intellectual Property Department

20080102492 - Methods and compositions for the prevention and treatment of anemia: Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a... Agent: Amgen Inc.

20080102497 - Enzymatic hydrolysis of starch: Provided herein are methods of increasing the enzymatic rate of hydrolysis of starch substrates. In certain embodiments the method comprises contacting a starch substrate with one or more amylase family enzymes in the presence of greater than 0.001 mM manganese ions. In certain embodiments, the method comprises contacting a starch... Agent: Calfee Halter & Griswold, LLP

20080102498 - Methods for the separation of streptococcus pneumoniae type 3 polysaccharides: The present invention provides improved methods for the reduction or removal of protein impurities from a complex cellular Streptococcus pneumoniae lysate or centrate comprising serotype 3 polysaccharides involving steps relating to post-lysis heating or pH adjustment. In certain methods, the lysate is heated for a time and at a temperature... Agent: Alston & Bird LLP

20080102499 - Method of enhancing l-tyrosine production in recombinant bacteria: Tyrosine production in a tyrosine over-producing enteric bacterial strain was enhanced by expression of a tyrosine insensitive prephenate dehydrogenase. The prephenate dehydrogenase expressed was the cyclohexadienyl dehydrogenase encoded by the Zymomonas mobilis tyrc gene.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080102500 - Lipase powder compositions: The present invention provides a lipase powder composition which comprises a filter aid(s) and a product obtained by pulverizing a Thermomyces sp.-derived lipase immobilized to a silica carrier(s) into the average particle diameter of 1 μm or more and less than 300 μm. This lipase powder composition improves the lipase... Agent: Buchanan, Ingersoll & Rooney PC

20080102501 - Method of production of optically active halohydrocarbons and alcohols using hydrolytic dehalogenation catalysed by haloalkane dehalogenases: A method of production of optically active compounds, particularly halohydrocarbons, haloalcohols, alcohols, halopolyols and polyols using hydrolytic dehalogenation of racemic or prochiral halegenhydrocarbons by dehalohenation catalysed by haloalkane dehalogenases (the enzyme code number EC 3.8.1.5) where at least one wild type or modified haloalkane dehalogenase is applied to at least... Agent: Notaro And Michalos

20080102502 - Inorganic salt recovery during processing of lignocellulosic feedstocks: A method for recovering inorganic salt during processing of a lignocellulosic feedstock is provided. The method comprises pretreating the lignocellulosic feedstock by adding an acid or a base to the feedstock to produce a pretreated lignocellulosic feedstock. A soluble base or acid is then added to the pretreated lignocellulosic feedstock... Agent: Fitzpatrick Cella Harper & Scinto

20080102503 - Systems and processes for cellulosic ethanol production: A cellulosic ethanol production process. Implementations may include providing a raw cellulose stream by mixing a waste cellulose feed and an algae cellulose feed and hydrolyzing the raw cellulose stream to form a hydrolyzed cellulose stream by reacting the raw cellulose stream with one or more fungi from the phylum... Agent: Booth Udall, PLC

20080102504 - Methods and apparatus for characterizing polynucleotides: Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure having a nanopore aperture and a molecular motor, e.g., a polymerase, adjacent the nanopore aperture.... Agent: Clark & Elbing LLP

20080102505 - Method of treating viral infections with ultraviolet light: A method of treating a viral infection by stimulating cell mediated immunity in a subject. Specifically, the instant method is performed by applying ultraviolet light to stimulating the subject's immune system to activate potent cell mediate immune responses, including inducing gene expression of various cytokines, against the specific viruses such... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20080102506 - Method for obtaining mesenchymal stem cells: The invention relates to the field of cell biology. In detail it relates to the obtainment of mesenchymal stem cells from human tissue. This invention might be applicable in healing within the frame of the treatment of several diseases. Due to the invention it will be possible to obtain mesenchymal... Agent: Klarquist Sparkman, LLP

20080102507 - Avian embryo particulate biomass for the production of virus antigens: The present invention provides a biomass which comprises avian embryonic particles having a particle size of about 0.5 mm to 10.0 mm and the use thereof in a method for the production of virus antigens. Also provided is a method for the preparation of a vaccine useful for the amelioration... Agent: Wyeth Patent Law Group

20080102508 - Formulation of adenovirus for gene therapy: The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use of bulking agents, cryoprotectants and lyoprotectants imparts desired properties that allow both lyophilized and liquid adenovirus formulations to be stored at 4°... Agent: Fulbright & Jaworski L.L.P.

20080102509 - Bacterial host cell for the direct expression of peptides: Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth... Agent: Ostrolenk Faber Gerb & Soffen

20080102510 - Bacterial host cell for the direct expression of peptides: Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with a special selection of hosts, and/or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth... Agent: Ostrolenk Faber Gerb & Soffen

20080102511 - Process for the joint culture of an association of microorganism, using pyrite (fes2) as and energy source: The invention publishes a process for the joint culture of an association of microorganisms using pyrite (FeS2) as an energy source. This invention particularly publishes the use of a pyrite ore as an energy source in the joint culture of an association of Acidithiobacillus ferrooxidans and Acidithiobacillus thiooxidans type isolated... Agent: Merchant & Gould PC

20080102512 - Culture method of antrodia camphorata: A culture method of a fruiting body of Antrodia camphorata is provided, which includes: (a) fermenting a culture medium containing yeast at 5-35° C. for 3-30 days; (b) adding wood flour to the fermented culture medium with stirring; (c) placing the wood flour and the culture medium into a vessel;... Agent: Bacon & Thomas, PLLC

20080102513 - Methods and mediums for cultivating dinophysis acuminata: Disclosed are a method and a medium for cultivating the marine dinoflagellate Dinophysis acuminata. The laboratory culture of D. acuminata causing diarrhetic shellfish poisoning, whose cultivation was known difficult, has been first established, thereby contributing to a better understanding of ecophysiology, biology and toxicology of Dinophysis species, as well as... Agent: Jhk Law

20080102514 - Reactor for the culture, biooxidation of solutions and/or large-scale propagation of isolated microorganisms and/or native microorganisms that are useful in ore leaching: The invention publishes a reactor and method for the culture, biooxidation of cations in solution and/or large-scale propagation of jointly isolated microorganisms, with or without native microorganisms that are useful in sulfide metal ore bioleaching. The invention particularly publishes a reactor for the large-scale culture and/or propagation of an association... Agent: Merchant & Gould PC

20080102515 - Use of mining waste and concentrates containing pyrite, in the culture of iron-oxidizing and sulfur-oxidizing microorganisms as an energy source for bacterial growth: The invention publishes the use of mining products and sub-products that contain pyrite, such as copper concentrates, and waste from the process in which these concentrates are obtained, known as scavenger tail, as an energy source for the large-scale culture of an association of microorganisms that are useful for ore... Agent: Merchant & Gould PC

20080102516 - Microinjection equipment: To provide a microinjection equipment capable of fitting a micro needle to a manipulator etc. manipulating the micro needle in short time on the occasion of an injection operation. Included are a micro needle transporting device 12 detachably grasping a micro needle 10 filled with an introduction substance and disposed... Agent: Staas & Halsey LLP

20080102517 - Nanocatalyst-based biosensor: Disclosed is a biosensor for electrochemically detecting the presence of an analyte and measuring its concentration. In the biosensor, an organic substance as a substrate is reduced to a substance having an amine group by the catalysis of a nanocatalyst label with a plurality of active sites in the presence... Agent: Sofer & Haroun LLP.

20080102518 - Plate and method for high throughput screening: A multiple well plate and method for media exchange, including a body defining a plurality of cell wells each connected via a channel to one of a plurality of aspiration holes, is provided. The cell wells contain a porous, hydrophilic frit which is suspended on a ledge above a reservoir... Agent: Alston & Bird LLP

20080102519 - Apparatus and method for preparative scale purification of nucleic acids: Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular debris including chromosomal DNA from the lysates. A gas is introduced to controllably generate bubbles that reduce the density of the cell debris and create a... Agent: Wong Cabello Lutsch Rutherford & Brucculeri, LLP

20080102520 - Novel human membrane proteins and polynucleotides encoding the same: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.... Agent: Lexicon Pharmaceuticals, Inc.

20080102521 - Stem cell banking system: Disclosed herein are methods for producing a stem cell bank and providing stem cell samples for purchase or use. Also, provided herein are embodiments relating to a stem cell bank and stem cell banking system.... Agent: Beusse Wolter Sanks Mora & Maire

20080102522 - Method of isolating cells from umbilical cord: The present invention relates a method for isolating four cell types from a single umbilical cord as pure cultures. These cell lines (epithelial cells, fibroblasts, smooth muscle cells and endothelial cells) can be characterised and utilised in experimental models and for therapeutic purposes. Particularly, the umbilical cells isolated herein are... Agent: David S. Resnick

20080102523 - Expression vector for animal cell comprising at least one copy of mar dna sequences at the 3'terminal of transcription termination region of a gene and method for the expression of foreign gene using the vector: Provided are an expression vector for an animal cell including a promoter, a cloning site or a polynucleotide encoding foreign product, and a transcription terminator, all of which are operably connected each other within the expression vector, in which at least one copy of human β-globin MAR sequence is attached... Agent: Cantor Colburn, LLP

20080102524 - Freeze-dried composition of inactivated virus envelope with membrane fusion activity: The present invention provides a freeze-dried composition for introducing a foreign matter which comprises an inactivated virus envelope having membrane fusion activity, and at least one stabilizer selected from the group consisting of a protein hydrolysate, leucine, an L-arginine-acid and a polysaccharide, and a method of introducing a foreign matter... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.