Chemistry: molecular biology and microbiology inventions 04/08

20080096188 - Method to predict degradation of a landfill: Determining when a landfill is stabilized by comparing the biological signature of a landfill over a predetermined time period with that of a known stabilized landfill.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080096186 - Pcr primer set for detecting severe acute respiratory syndrome (sars)-coronavirus, method and kit for detecting sars-coronavirus using the same: Provided are SARS-CoV detection PCR primers having nucleotide sequences as set forth in SEQ ID NOS: 1-46, a method for detecting SARS-CoV using the primers, and a SARS-CoV detection kit including the primers.... Agent: Cantor Colburn, LLP

20080096196 - Method for analyzing samples by means of hybridization: o

20080096194 - Method for de novo detection of sequences in nucleic acids: target sequencing by fragmentation: The present invention provides a method for determining nucleic acid sequences of a template nucleic acid that requires no prior knowledge of the nucleic acid sequence present in the template nucleic acid. The method is based on combining information about the mass of a fragment, the mass of any one... Agent: Ronald I. Eisenstein

20080096193 - Methods and compositions for detecting polynucleotides: Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a nucleic acid analog that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in... Agent: Donald Silvert Brinks Hofer Gilson & Lione

20080096192 - Nucleic acid amplification assay and arrangement therefor: A nucleic acid amplification assay for quantitative and/or qualitative analysis of the presence of a specific analyte or specific analytes in a biological sample, which analytes, if present, are contained in particles (4) of the sample (2), in which assay the sample is forced in a first direction through a... Agent: James C. Lydon

20080096195 - Salmonella selective enrichment medium containing tetrathionate and magnesium salt: The invention relates to a salmonella selective enrichment medium containing tetrathionate or a salt thereof and at least one type of magnesium salt and to a method for detecting salmonella in a sample by using said selective enrichment medium.... Agent: Alston & Bird LLP

20080096219 - Biological molecule-immobilized chip and its use: e

20080096220 - Novel triazine-based detoxification agents and their use: wherein one X is N and the other X is N, CCL or CCn; A1 and A2 are each independently O, S or N-R1 and R1 is H, C1-6 alkyl, C1-6 hydroxyalkyl, benzyl or β-phenylethyl; B1 and B2 are each independently an optionally substituted hydrocarbon linkage containing from 1 to... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080096232 - Methods for the detection and diagnosis of trypanosoma cruzi infection: The present invention relates to the diagnosis of Trypanosoma cruzi infection.... Agent: Robert Deberardine Abbott Laboratories

20080096233 - Isolation of immune complexes: The present invention provides methods of detecting and/or isolating immune complexes. The antigen in the immune complexes can further be isolated from the immune complexes to facilitate research and characterization of the antigen. Other embodiments of the present invention can be used to, inter alia, develop assays for detecting immune... Agent: Agilent Technologies Inc.

20080096241 - Method of detecting drug resistant microorganisms by surface plasmon resonance system: The present invention relates to a method and a device for detecting a drug resistant microorganism by surface plasmon resonance (SPR).... Agent: Harness, Dickey & Pierce, P.L.C

20080096245 - Cystatin-based peptide tags for the expression and purification of bioactive peptides: Cystatin-based peptide tags, referred to here as inclusion body tags (IBTs), are disclosed useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080096246 - Zein-based peptide tags for the expression and purification of bioactive peptides: Zein-based peptide tags, referred to here as inclusion body tags (IBTs), are disclosed useful for the generation of insoluble fusion peptides. The fusion peptides comprise at least one inclusion body tag operably linked to a peptide of interest. Expression of the fusion peptide in a host cell results in a... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080096252 - Production and purification of il-29: The expression vectors and methods using an E. Coli expression system for the large scale production of IL-29 are described. The vectors utilize the IL-29 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Also included are methods... Agent: Zymogenetics, Inc. Intellectual Property Department

20080096255 - Method for preparing sequence tags: Means to circulate any nucleic acid molecule and to obtain from such circular nucleic acid molecules fragments that mark both ends of the initial nucleic acid molecule are provided. Means of high value to studies including, but not limited to, expression profiling, splicing, promoter identification, identification of genetic elements, and... Agent: Alston & Bird LLP

20080096184 - System for exsanguinous metabolic support of an organ or tissue: An exsanguinous metabolic support system for maintaining an organ or tissue at a near normal metabolic rate is disclosed that employs a warm perfusion solution capable of altering the production of nitric oxide (NO) in an organ or tissue and supporting the metabolism of the organ or tissue at normothermic... Agent: Heslin Rothenberg Farley & Mesiti PC

20080096185 - Method for eliminating potentially toxic and/or harmful substances: The invention describes a method for eliminating potentially toxic and/or harmful substances, wherein particles which are capable of binding, taking up and/or carrying the toxic and/or harmful substances, are removed from a body fluid in an extracorporeal step or in an extrinsic or exogeneous device.... Agent: Edwards Angell Palmer & Dodge LLP

20080096189 - Device and method for detection of analytes: The present invention provides assays and devices for detection of substances in liquid samples. The assays and devices utilize passive diffusion between a porous material and a porous membrane containing a specific binding pair member to enable detection of the substance of interest.... Agent: Latimer, Mayberry & MatthewsIPLaw, LLP

20080096191 - Methods and systems for detection and isolation of a nucleotide sequence: A method for isolating nucleic acid molecules having a repeating nucleotide sequence or a homopolymeric nucleotide sequence, e.g. a poly A stretch, is described. In particular, the method uses oligomeric capture probes spiked with various amounts of locked nucleic acid (LNA). The invention further describes methods for the isolation of... Agent: Edwards Angell Palmer & Dodge LLP

20080096187 - Molecular scaffolds for hiv-1 epitopes: Methods and compositions are provided for the use of an envelope polypeptide or a functional variant thereof from a lentivirus that is not HIV-1 as a molecular scaffold for HIV-1 epitopes. The HIV-1 epitopes can be recognized by HIV-1 binding antibodies, HIV-1 neutralizing antibodies and/or CD4-induced antibodies. Thus, methods are... Agent: Alston & Bird LLP

20080096190 - Sequences diagnostic for shrimp pathogens: Primers have been isolated that are diagnostic for the detection of the white spot syndrome virus (WSSV). The primers are based on a new portion of the WSSV genome and may be used in primer directed amplification or nucleic acid hybridization assay methods.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080096209 - Analysis of hiv-1 coreceptor use in the clinical care of hiv-1-infected patients: A change in viral tropism occurs in many HIV positive individuals over time and can be indicated by a change in coreceptor usage from CCR5 to CXCR4. The change in coreceptor usage to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations... Agent: Frommer Lawrence & Haug

20080096202 - Animal models for demyelination disorders: This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in... Agent: Wilson Sonsini Goodrich & Rosati

20080096201 - Assay for identifying biological targets of polynucleotide-binding compounds: The present invention provides methods and systems for the identification of a biological target of a chemical compound, such as saframycin A, known to bind a polynucleotide. The invention also provides methods of screening chemical compounds for those which act in a similar method and may be more potent than... Agent: Choate, Hall & Stewart/harvard University

20080096208 - Biomarkers for assessing response to c-met treatment: Biomarkers that correlate to treatment with drugs that inhibit c-met are disclosed. These biomarkers have been shown to have utility in assessing response to the compounds. The expression level of the biomarkers is reduced upon treatment with c-met inhibitor compounds, thus indicating that these biomarkers are involved in c-met activity.... Agent: Philip S. Johnson Johnson & Johnson

20080096210 - Cancer suppressing agent: An object of the present invention is to provide a cancer suppressing agent containing a cancer suppressing gene that is discovered through the use of a novel method rather than through existing methods. The present invention provides a cancer suppressing agent which comprises an RGC32 gene or a gene homologous... Agent: Birch Stewart Kolasch & Birch

20080096215 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Genentech, Inc.

20080096197 - Compounds and methods for assessment of microsatellite instability (msi) status: The present invention provides a method for assessment of the Microsatellite Instability (MSI) status of medically relevant conditions associated with MSI phenotype such as e.g. neoplastic lesions. The method is based on the analysis of a monomorphic T25 (CAT25) mononucleotide repeat located in the 3′-UTR of the Caspase 2 (CASP2)... Agent: Howrey LLP

20080096211 - Corynebacterium glutamicum genes encoding proteins involved in genetic stability, gene expression, and protein secretion and folding: Isolated nucleic acid molecules, designated SES nucleic acid molecules, which encode novel SES proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SES nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20080096205 - Diagnostic methods and kits for colorectal cancer: The present application discloses a diagnostic method and a kit for prognosis assessment of colorectal cancer (CRC) and a novel tumor suppressor gene to be used for diagnosis of colorectal cancer (CRC), the method comprising the steps of: (a) identifying recurrently altered regions (RAR) on a chromosome; and (b) detecting... Agent: Edwards Angell Palmer & Dodge LLP

20080096207 - Leptin and growth hormone receptor gene markers associated with rearing, carcass traits and productive life in cattle: The invention provides a method for sub-grouping animals according to genotype wherein the animals of each sub-group have a similar polymorphism or combination of polymorphisms in the leptin gene selected from the group consisting of UASMS1, UASMS2, UASMS3, EXON2-FB, and E2JW. The combination of single nucleotide polymorphisms of the leptin... Agent: Frommer Lawrence & Haug

20080096204 - Method and apparatus for determining cancer metastasis: A method which can objectively determine to what extent a cancer cell has metastasized to a lymph node, the method being a method for determining a size of a metastatic focus, including a step of quantitating a tumor marker mRNA in an assay sample prepared from a lymph node suspected... Agent: Sughrue Mion, PLLC

20080096203 - Method and device for detecting quinolone-resistant escherichia coli: The present invention pertains to a method for detecting quinolone-resistant Escherichia coli strains in a biological sample. The present invention also relates to a kit adapted to perform the inventive method.... Agent: Foley And Lardner LLP Suite 500

20080096214 - Method for agitating the fluid contents of a container: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080096213 - Method for confirming conversion treatment and nucleic acid molecule used therefor: There is provided a method for confirming conversion treatment of non-methylated cytosine, including a step of mixing a DNA taken from a living body, with a nucleic acid for accuracy control having a sequence A which is not contained in a genome of the living body and contains cytosine, a... Agent: Sughrue Mion, PLLC

20080096199 - Method for the carry-over protection in dna amplification systems targeting methylation analysis achieved by a modified pre-treatment of nucleic acids: Disclosed is a method for the specific amplification of template DNA in the presence of potentially contaminating PCR products from previous amplification experiments. In the first step DNA is contacted with a bisulfite solution, which reacts with unmethylated cytosines but not with methylated cytosines, by sulfonating them. This results in... Agent: Kriegsman & Kriegsman

20080096212 - Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments: The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensitivity to the tyrosine kinase inhibitor gefitinib. Thus,... Agent: David S. Resnick

20080096216 - Methods and apparatuses for analyzing polynucleotide sequences: Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080096200 - Methods for detection of a target nucleic acid by capture using multi-subunit probes: The invention relates to generating a signal indicative of a target nucleic acid sequence, comprising forming a complex by incubating a sample comprising a target nucleic acid sequence with a probe comprising a first and second subunit, and a binding moiety, and dissociating the first and second subunit to release... Agent: Agilent Techologies Inc

20080096217 - Methods for evaluating pathologic conditions using extracellular rna: This invention provides methods for the detection, diagnosing, monitoring, or predicting of non-neoplastic diseases, pathologic conditions, and injury. The methods of the invention detect extracellular non-neoplastic mammalian RNA in the blood, blood plasma, serum, or other bodily fluid of an animal, most preferably a human, having or predisposed to having... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080096218 - Polynucleotide encoding a maize herbicide resistance gene and methods for use: This invention relates to polynucleotide sequences encoding a gene that can confer resistance to at least one herbicide. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to at least one herbicide, and methods of making said plants... Agent: Pioneer Hi-bred International, Inc.

20080096206 - Polynucleotide sequencing using a helicase: The present invention pertains to a method for sequencing a polynucleotide, comprising the steps of: (i) reacting a target polynucleotide with a helicase/primase enzyme (which may be immobilised), under conditions suitable for enzyme activity; and (ii) detecting the interaction between the enzyme and a nucleotide on the target, by measuring... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080096198 - Primer having promoter region added thereto: It is intended to provide a primer having a promoter region added thereto; and a method of using the primer having a promoter region added thereto in RNA amplification, gene expression analysis and/or identification analysis of an organism. A primer is constructed by adding a promoter region to a random... Agent: Young & Thompson

20080096225 - Assays for detecting modulators of cytoskeletal function: Described herein are methods of identifying compounds which modulate the activity of the cytoskeletal system. The methods are rapid, convenient and sensitive. Preferably, the method is used to identify lead compounds that can be used as therapeutics, diagnostics and agricultural agents. Generally, test compounds are added to two cytoskeletal components... Agent: Medlen & Carroll, LLP

20080096222 - Compositions and methods based upon the kinase haspin: The present invention is directed to methods for increasing or decreasing the phosphorylation of histone H3 using factors that alter the activity of the kinase haspin. The invention includes assays for identifying inhibitors, peptides that can serve as inhibitors or in the generation of antibodies that specifically recognize phosphorylated histone,... Agent: Law Office Of Michael A. Sanzo, LLC

20080096224 - Emission ratiometric indicators of phosphoinositides: Emission ratiometric indicators of phosphoinositides comprise a fusion protein comprising a pleckstrin homology (PH) domain of Akt (also known as protein kinase B) and a “pseudoligand” containing acidic amino acid residues, which is sandwiched between resonance energy transfer (RET) pairs, such as cyan and yellow mutants of GFP (a FRET... Agent: Banner & Witcoff, Ltd.

20080096226 - Method for predicting responsiveness of breast cancer to antiestrogen therapy: The invention is directed to diagnostic and monitoring methods (assays) for cancer and kits that may be used in such methods. More particularly, an aspect of the invention relates to the use of activated Stat5 for diagnosing and monitoring breast cancer and predicting the effectiveness of cancer treatment. The invention... Agent: Conley Rose, P.C. David A. Rose

20080096221 - Method of detecting platelet thrombosis or organ failure: A method of detecting platelet thrombosis or organ failure in a patient suffering from disseminated intravascular coagulation (DIC) or systemic inflammatory response syndrome (SIRS), comprising analyzing a von Willebrand factor-cleaving protease and/or a cleaving factor thereof, is disclosed. A kit for detecting platelet thrombosis or organ failure in a patient... Agent: Heslin Rothenberg Farley & Mesiti PC

20080096223 - Methods and assays for distinguishing between different forms of diseases and disorders characterized by thrombocytopenia and/or by spontaneous interaction between von willebrand factor (vwf) and platelets: The invention relates to a method for distinguishing between different states or forms of diseases and disorders characterized by thrombocytopenia and/or by spontaneous interaction between Von Willebrand Factor (vWF) and platelets, and/or to predict the progression of such a disease or disorder, said method comprising the steps of providing at... Agent: Wolf Greenfield & Sacks, P.C.

20080096227 - Crac modulators and use of same for drug discovery: The invention relates to use of a calcium release activated Ca+2 (CRAC) channel (CRACM) such as CRACM1 and CRACM2 to identify bioactive agents which can modulate store operated calcium entry and CRAC channel activity. The invention further relates to the use of recombinant nucleic acids that encode CRACM. One aspect... Agent: Morgan, Lewis & Bockius, LLP

20080096231 - Simultaneous assay of target and target-drug binding: Whole cell, simultaneous target and drug-target assay using differentially labeled antibodies and flow cytometry. First antibody binds to total target and second antibody binds to the drug binding site of the target, thus drug binding will competitively inhibit the second antibody allowing for a competitive inhibition assay of drug-target binding.... Agent: Baker & Mckenzie LLP

20080096235 - Biomarkers for cancer sensitivity and uses thereof: Disclosed herein are biomarkers and uses thereof for evaluating anti-cancer efficacy and sensitivity.... Agent: Fish & Richardson P.C.

20080096234 - Method for examining carcinoma and adenoma: [MEANS FOR SOLVING PROBLEMS] Significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, between non-carcinoma tissues and carcinoma tissues or adenoma tissues were discovered. The discovery is evidently applicable to detect carcinomas and adenomas (except colorectal carcinomas and colorectal adenomas) specifically by assaying a certain range... Agent: Drinker Biddle & Reath (dc)

20080096236 - Method for detecting the presence of target bacteria or a target component carbohydrate antigen thereof: A process is disclosed for separating a carbohydrate antigen from a Gram-positive or Gram-negative bacteria in a purified form that contains no more than 10% protein. The separated antigen is coupled to an affinity column, over which polyclonal antibodies to the same bacteria are chromatographed and recovered in a purified... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080096228 - Compositions and methods relating to mammalian internal ribosome entry sites: Contemplated compositions and methods are directed to IRES sequences and their use, especially in the context of CML. Among other contemplated aspects IRES sequences described herein are highly active in recombinant in vitro systems and allow high-level of recombinant protein from two, typically opposite reading frames. In vivo, and particularly... Agent: Fish & Associates, PC Robert D. Fish

20080096230 - Methods for assaying percentage of glycated hemoglobin: The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular... Agent: Morrison & Foerster LLP

20080096229 - Modified flagellins and flagellar filaments useful as receptors and methods for the preparation thereof: In general, the invention relates to receptors capable of the efficient recognition and binding of target molecules, said receptors being composed of flagellin proteins which comprise the flagellar filaments of bacteria. More closely, the invention relates to modified flagellins or flagellin fragments useful as receptors, and filamentous receptor-structures comprising them.... Agent: Hahn & Voight PLLC

20080096238 - High throughput assay for human rho kinase activity with enhanced signal-to-noise ratio: The present invention provides a high throughput assay with increased signal-to-noise ration for human Rho kinase activity in vitro, and methods and kits therefor. A high throughput method of assaying a test compound for human Rho kinase modulating activity is also provided.... Agent: Winstead PC

20080096237 - Method for identifying agents which modulate cell growth or survival: The present invention relates to a method for identifying an agent, for modulating cell growth or survival. The method involves the identification of an agent which modulates the net ratio of nuclear-localized versus cytosolic-localized H11 kinase or mutant H11 kinase in a cell. A method for diagnosing a cancer associated... Agent: Licata & Tyrrell P.C.

20080096240 - Novel prostamide receptor antagonists: e

20080096239 - Orphan nuclear receptor: The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monoxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B475

20080096242 - Enhanced substrate conversion efficiency of fermentation processes: The present invention relates to the field of fermentation technology. In particular the invention relates to fermentation processes for the production of a first and a second fermentation product by a single production organism wherein the first product is in a more reduced state than the substrate and the second... Agent: Morgan Lewis & Bockius LLP

20080096243 - Soy protein isolate and process for its manufacture: A soy protein isolate and method for preparing the same are disclosed. The novel soy protein isolate possesses excellent suspension stability and flavor. The process used to produce the soy protein isolate includes an enzyme hydrolysis process, and the resulting soy protein isolate can be used in acidic beverage formulations.... Agent: Solae, LLC

20080096249 - Agarase and gene thereof: Production of efficiently producing agaro-oligosaccharide; a polypeptide having an agarase activity which is usable in, for example, efficiently extracting a substance such as a nucleic acid from an agarose gel; the amino acid sequence of the polypeptide; a gene encoding the polypeptide; a process for producing the polypeptide; a process... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080096244 - D-aminoacylase: A D-aminoacylase produced by a microorganism of genus Defluvibacter; which acts on a N-acetyl-D-amino acid; which has a molecular weight (as determined by electrophoresis) of about 55,000 daltons, and an isoelectric point (as determined by two-dimensional electrophoresis for denatured system) of 5.3; which acts on N-acetyl-D-valine, N-acetyl-D-leucine, and the like,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080096248 - Modified clostridial toxins with enhanced targeting capabilities for endogenous clostridial toxin receptor systems: The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.... Agent: Allergan, Inc.

20080096247 - Nucleic acids encoding duramycin: Nucleic acids encoding preduramycin and produramycin are described, along with recombinant nucleic acids host cells containing the same and methods of use thereof, such as for the manufacture of the lantibiotic duramycin.... Agent: King & Spalding LLP

20080096250 - Toll/interleukin-1 receptor adapter protein (tirap): TIRAP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TIRAP polypeptides and polynucleotides in therapy, and diagnostic assays for such.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080096251 - Invertebrate-derived gonadotropic hormone and its synthesis: The structure of gonadotropic hormone of an invertebrate (Asterina pectinifera) was elucidated. The gonadotropic hormone is a peptide with molecular weight 4500 to 4900 composed of two subunits, wherein the structure of the protein has the structure bound by SS bridges formed between SH residues of cysteines contained in the... Agent: Drinker Biddle & Reath (dc)

20080096253 - Methods of making nanotechnological and macromolecular biomimetic structures: The present invention is in the fields of nanotechology and biomimetics. In particular, the present invention relates to the use of modified ribosomes to produce biomimetic structures. These biomimetic structures, also known as directed element polymers, are not produced by traditional industrial means but instead are produced by living systems... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080096254 - Process for producing alpha1,4-galactosyltransferase and galactose-containing complex carbohydrate: The present invention can provide a process for producing a protein having α1.4-galactosyltransferase activity using a transformant comprising a DNA encoding a protein having α1.4-galactosyltransferase activity derived from a microorganism belonging to the genus Pasteurella and a process for producing a galactose-containing complex carbohydrate using a transformant capable of producing... Agent: Fitzpatrick Cella Harper & Scinto

20080096256 - Method for gene expression: The invention relates to a method for gene expression in a cell-free translation system, wherein the reaction solution comprises an RNA matrix with a gene sequence, which codes for an expression product to be expressed, and a translation system from eukaryotic cells, wherein the reaction solution is incubated, and wherein... Agent: Mayer & Williams PC

20080096257 - Methods for rapid, single-step strand displacement amplification of nucleic acids: A single-step, isothermal strand displacement amplification method that is conducted without the requirement for heat denaturation of the target nucleic acid. The method is particularly useful for analysis of clinical samples due to the decreased risk of potential contamination of the patient sample.... Agent: O''melveny & Myers LLP Ip&t Calendar Department La-1118

20080096258 - Rolling circle amplification of circular genomes: Disclosed are compositions and a method for amplification of circular genomes. The method is based on rolling circle amplification of the circular genomes which involves strand displacement replication by primers. The disclosed method allows differential amplification of circular genomes of interest. In genomic nucleic acid samples containing both a circular... Agent: Needle & Rosenberg, P.C.

20080096259 - Method of aminoacylating trna: It is intended to provide a method of chemically synthesizing an aminoacyl tRNA which is completely different from the existing methods, namely, a highly efficient and practically usable method for synthesizing an aminoacyl tRNA whereby any nonnatural amino acid can be conveniently aminoacylated without a need for genetic engineering techniques... Agent: Rader Fishman & Grauer PLLC

20080096260 - Method of preparing a heat-treated product: The formation of acrylamide during heat treatment in the production of a food product is reduced by treating the raw material with an enzyme before the heat treatment. The enzyme is capable of reacting on asparagine as a substrate.... Agent: Novozymes North America, Inc.

20080096261 - Alcohol production using sonication: A system comprising one or more transducers and an alcohol production facility having a liquid medium processing stream, the alcohol production facility adapted for use with the one or more transducers is provided. In one embodiment, the one or more transducers apply sonication to the liquid medium processing stream in... Agent: Schwegman, Lundberg & Woessner, P.A.

20080096262 - Method for enhancing polymerase activity: A polymerase activity is effectively enhanced by adding an anionic surfactant, in particular an anionic surfactant having a polyethoxyl group, to a reaction mixture containing a polymerase.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080096264 - Attenuated parainfluenza virus (piv) vaccines: The invention provides isolated nucleic acids encoding recombinant genomes or antigenomes of Human Parainfluenza Viruses that are useful as vaccines. The recombinant genomes or antigenomes can be incorporated into expression vectors for production of recombinant viruses in vitro. The invention also provides recombinant Human Parainfluenza viruses having one or more... Agent: Birch, Stewart, Kolasch & Birch, LLP

20080096263 - Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from respiratory syncytial virus: The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products... Agent: Johnathan Klein-evans

20080096265 - Culture medium for the production of filamentary fungi: A culture medium for filamentary fungi comprising at least one carbon source chosen from the group consisting of molasses, malt extract and sucrose a nd at least one organic nitrogen source chosen from yeast extract and corn steep liquor is described; a method for producing filamentary fungi, in particular nematophagus... Agent: Akerman Senterfitt

20080096266 - Method for stabilizing the antiallergic activity of lactic acid bacteria against high-temperature treatment, stabilized compositons, and food and drink: The present invention provides a method for stabilizing an antiallergic activity of lactic acid bacteria against a high-temperature treatment and a composition for the stabilization, which can maintain an antiallergic activity of lactic acid bacteria against a high-temperature treatment, and foods and drinks such as drinks having a stabilized antiallergic... Agent: Foley And Lardner LLP Suite 500

20080096267 - Systems and methods for large-scale production and harvesting of oil-rich algae: Systems and methods for the growing of microorganisms such as algae, yeast, and bacteria are described. Seed fermentation units are associated with final fermentation ponds in various arrangements. Continuous, semicontinuous, fed batch, and batch modes of operation of the seed and final fermentations are included. Harvest methods for the cellular... Agent: Knobbe Martens Olson & Bear LLP

20080096268 - Biotrickling filter packing material and systems and methods of using same to remove odour causing compounds from waste gas streams: The present invention relates to biotrickling filter systems and the packing material employed in such systems, as well as, methods of using same to remove odour causing compounds from waste gas streams. The packing material for the biotrickling filter system includes a plurality of expanded glass granules. When used in... Agent: Fasken Martineau Dumoulin LLP

20080096269 - Plate and method for high throughput screening: A multiple well plate and method for media exchange, including a body defining a plurality of cell wells each connected via a channel to one of a plurality of aspiration holes, is provided. The cell wells contain a porous, hydrophilic frit which is suspended on a ledge above a reservoir... Agent: Alston & Bird LLP

20080096270 - Plate and method for high throughput screening: A multiple well plate and method for media exchange, including a body defining a plurality of cell wells each connected via a channel to one of a plurality of aspiration holes, is provided. The cell wells contain a porous, hydrophilic frit which is suspended on a ledge above a reservoir... Agent: Alston & Bird LLP

20080096271 - Polymeric self-assembly multiplayer membranes for ion screening: design, fabrication and application in sensors: The embodiments of the invention are related to an extrinsically compensated multilayer membrane comprising at least a first layer comprising charged polymers and a second layer comprising neutral polymers, wherein the first layer is characteristic of extrinsic compensation and the charges on the polymer are balanced by mobile counter ions.... Agent: Darby & Darby P.C.

20080096272 - Plate and method for high throughput screening: A multiple well plate and method for media exchange, including a body defining a plurality of cell wells each connected via a channel to one of a plurality of aspiration holes, is provided. The cell wells contain a porous, hydrophilic frit which is suspended on a ledge above a reservoir... Agent: Alston & Bird LLP

20080096273 - Method for preparing conditioned medium of astrocyte-like cells: Disclosed are a method for preparing a conditioned medium of astrocyte-like cells derived from embryonic stem cells, characterized in that astrocyte-like cells, which are prepared by differentiation of embryonic stem cells, are cultured; the medium obtained by said method, the use of the conditioned medium for culturing neural cells as... Agent: Birch Stewart Kolasch & Birch

20080096274 - Recombinant alphavirus vectors and methods of using same: The present invention describes nucleic acid segments, recombinant alphavirus vectors, and recombinant alphavirus particles that include a Sindbis viral vector. The Sindbis viral vector includes a nucleic acid segment encoding a fusion protein comprising a Sindbis virus nonstructural protein and a protein or peptide of interest, wherein the production of... Agent: Dunlap Codding & Rogers, P.C.

20080096275 - Protein for improving cell-attachment efficiency and use thereof: The present invention provides a method for improving cell-attachment efficiency comprising (a) preparing a protein in aqueous solution, wherein the protein has a formula A-B-C, wherein A represents a GRGDS amino acid sequence; B represents a cellulose binding domain (CBD); and C represents a GRGDS amino acid sequence, an RGD... Agent: Wpat, PC Intellectual Property Attorneys

20080096276 - Cis-prenyltransferases from plants: This invention pertains to nucleic acid fragments encoding plant proteins that are homologs to the cis-prenyltransferases UPP synthase from the bacterium Micrococcus luteus or Dedol-PP synthase from yeast Saccharomyces cerevisiae. More specifically, this invention pertains to cis-prenyltransferase homologs from wheat, grape, soybean, rice, African daisy, rubber tree latex and pot... Agent: Pioneer Hi-bred International, Inc.

20080096277 - Plant with reduced protein content in seed, method of constructing the same and method of using the same: It is intended to provide a method of reducing the total amount of stored protein, to develop a technique required therefor, and to provide a plant and its seeds developed by the above method and a method of using such a plant and seeds. More specifically, a nucleic acid molecule... Agent: Perkins Coie LLP

20080096278 - Rf2a and rf2b transcription factors: A method of activating the rice tungro bacilliform virus (RTBV) promoter in vivo is disclosed. The RTBV promoter is activated by exposure to at least one protein selected from the group consisting of Rf2a and Rf2b.... Agent: Bryan Cave LLP

20080096279 - Nucleic acid sequences encoding luciferase for expression in filamentous fungi: The present invention relates to genetic reporters. Specifically, the present invention is directed to a modified gene encoding a luciferase for high level expression in an organism with a bias for cytosine (C) or guanine (G) in the third position of the codon.... Agent: Licata & Tyrrell P.C.

20080090224 - Nucleic acid detection: The present invention relates to a process for the detection of nucleic acids from biological or environmental samples. The technique involves the amplification of the nucleic acid of interest, after conversion to cDNA if necessary, after which the amplified nucleic acid is used as the template for further amplification by... Agent: Heslin Rothenberg Farley & Mesiti PC

20080090228 - Devices for generating detectable polymers: This document provides systems, devices, and methods involved in generating detectable polymers. For example, diagnostic systems, diagnostic devices, primer systems, and collections of primer systems are provided.... Agent: Fish & Richardson P.C.

20080090229 - Devices for generating detectable polymers: This document provides systems, devices, and methods involved in generating detectable polymers. For example, diagnostic systems, diagnostic devices, primer systems, and collections of primer systems are provided.... Agent: Fish & Richardson P.C.

20080090230 - Devices for generating detectable polymers: This document provides systems, devices, and methods involved in generating detectable polymers. For example, diagnostic systems, diagnostic devices, primer systems, and collections of primer systems are provided.... Agent: Fish & Richardson P.C.

20080090231 - Devices for generating detectable polymers: This document provides systems, devices, and methods involved in generating detectable polymers. For example, diagnostic systems, diagnostic devices, primer systems, and collections of primer systems are provided.... Agent: Fish & Richardson P.C.

20080090232 - Devices for generating detectable polymers: This document provides systems, devices, and methods involved in generating detectable polymers. For example, diagnostic systems, diagnostic devices, primer systems, and collections of primer systems are provided.... Agent: Fish & Richardson P.C.

20080090234 - Diagnostic assay for autoimmune lymphoproliferative syndrome (alps) and genetically related disorders: The methods and compositions of the invention find use in the clinical diagnosis of TNFRSF6-related syndromes, particularly autoimmune lymphoproliferative syndrome (ALPS). The compositions of the invention include isolated nucleic acid molecules and oligonucleotide pairs suitable for use in amplifying regions of the TNFRSF6 gene and in determining the nucleotide sequence... Agent: Taft, Stettinius & Hollister LLP

20080090238 - Increased sensitivity of proximity ligation assays: Methods for enhancing the sensitivity of proximity ligation assays are provided herein. The methods make use of size separation methods, control of oligonucleotide size, and control of reaction conditions, to improve the assay sensitivity. Kits for performing the assay are also described.... Agent: Agilent Technologies Inc.

20080090237 - Methods and compositions for comparing chromosomal copy number between genomic samples: Methods and compositions for detecting copy number variations between nucleic acid samples are provided. Also provided are kits for practicing methods in accordance with the invention.... Agent: Agilent Technologies Inc.

20080090236 - Methods and systems for identifying tumor progression in comparative genomic hybridization data: Methods for identification of statistically significant combinatorial patterns in CGH data that are indicative of the progression of chromosomal aberrations in tumors. The methods comprise acquiring comparative genomic hybridization data, identifying a long order preserving subset within the comparative genomic hybridization data, and identifying a chromosomal aberration associated with the... Agent: Agilent Technologies Inc.

20080090233 - Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients: Disclosed are biomarkers, methods and assay kits for the identification of cancer patients who are predicted to benefit, or not to benefit, from the therapeutic administration of an epidermal growth factor receptor (EGFR) inhibitor. The biomarkers of the present invention include detection of EGFR and HER 2 gene amplification and... Agent: Sheridan Ross PC

20080090227 - Methods of chromosome drying and spreading: The present invention provides for a method of drying and spreading chromosomes from various biological samples to yield optimal chromosomal spreading. The method requires preparing a biological sample for treatment, providing a cytogenetic chamber capable of setting predetermined conditions, pre-testing a portion of the biological sample in the cytogenetic chamber,... Agent: Triangle Patents, P.l.l.c.

20080090235 - Unstructured nucleic acid pcr primers and methods of using the same: A polymerase chain reaction (PCR) mixture containing at least one unstructured nucleic acid primer pair is provided. In certain embodiments, the mixture may also contain: nucleotides, a DNA polymerase, and PCR reaction reagents, as well as a nucleic acid sample. The reaction mixture may be employed in, for example, a... Agent: Agilent Technologies Inc.

20080090248 - Surface-plasmon resonance-based methods for identifying kinases and their substrates: An assay method is provided. In certain embodiments, the method includes: a) contacting a sample with a polypeptide that is linked to a surface of a surface plasmon resonance sensor under kinasing conditions to produce a sample-contacted substrate; b) separating the sample and the sample-contacted substrate to produce a sample-separated... Agent: Agilent Technologies Inc.

20080090256 - Reducing optical interference in a fluidic device: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications. In particular, the medical device reduces... Agent: Wilson Sonsini Goodrich & Rosati

20080090263 - Two secretory luciferases: The present invention is one gene construct or a combination of two gene constructs or expression vectors incorporating a Cypridina luciferase gene and a copepod luciferase under the control of distinct promoters. These gene constructs and expression vectors are useful for making a mammalian cell incorporating the Cypridina luciferase gene... Agent: Knobbe Martens Olson & Bear LLP

20080090264 - Devices and methods for profiling enzyme substrates: The present invention relates to apparatus and methods for separating and detecting enzyme substrates using separation gels. For example, the apparatus and methods can be used to separate and detect kinase substrates for further analysis. The apparatus and methods can also be used to detect enzyme inhibitors, such as kinase... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080090267 - Method for treating living samples and analyzing the same: A method is provided by which a reagent is provided to a living sample, including contacting a thin-film containing a porous body with a living sample containing cells or tissues, and discharging a solution containing at least one or more reagents to a non-contact side of the thin-film by ink-jet... Agent: Fitzpatrick Cella Harper & Scinto

20080090222 - Virus-inactivated hemoglobin and method of producing the same: [SOLVING MEANS] A method of producing virus-inactivated hemoglobin, which includes: an SD treatment step of bringing erythrocytes and a mixture of a solvent and a detergent into contact with each other to simultaneously conduct an erythrocyte hemolysis treatment and viral inactivation treatment of said erythrocytes and a purification step of... Agent: Buchanan, Ingersoll & Rooney PC

20080090223 - Method for diagnosing hepatic diseases: The invention concerns a method for early diagnosis of hepatic diseases, which consists in determining in the samples of the diseased subjects, the presence of a apolipoprotein AI (Apo-AI) isoform, having oxidised W50, W108, and M112 residues. The inventive method is useful for diagnosing hepatocellular carcinoma and hepatitis B.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080090225 - Methods of identifying anti-viral agents: The present invention provides methods of identifying candidate anti-viral agents.... Agent: Bozicevic, Field & Francis LLP

20080090226 - Novel antigen constructs useful in the detection and differentiation of antibodies to hiv: Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences... Agent: Robert Deberardine Abbott Laboratories

20080090246 - Amplification and detection method: The present invention concerns oligonucleotides containing one or more modified nucleotides which increase the binding affinity of the oligonucleotides to target nucleic acids having a complementary nucleotide base sequence. These modified oligonucleotides hybridize to the target sequence at a faster rate than unmodified oligonucleotides having an identical nucleotide base sequence.... Agent: Gen Probe Incorporated

20080090241 - Cot102 insecticidal cotton: The present application relates to an insect resistant transgenic cotton plant, In particular, it relates to a specific event, designated COT102. The application also relates to polytucleotides which are characteristic of the COT102 event, plants comprising said polynucleotides, and methods of detecting the COT102 event. The COT 102 event exhibits... Agent: Syngenta Biotechnology, Inc. Patent Department

20080090245 - Diagnosing and treating hematopoietic cancers: Described herein are methods and compositions comprising Wnt5a for the diagnosis and treatment of hematopoietic cancers, and methods of identifying therapeutic compounds for the treatment of hematopoietic cancers.... Agent: Fish & Richardson PC

20080090247 - Method for detecting a structured target: The present invention concerns oligonucleotides containing one or more modified nucleotides which increase the binding affinity of the oligonucleotides to target nucleic acids having a complementary nucleotide base sequence. These modified oligonucleotides hybridize to the target sequence at a faster rate than unmodified oligonucleotides having an identical nucleotide base sequence.... Agent: Gen Probe Incorporated

20080090244 - Methods of detecting low copy nucleic acids: Methods are provided for detecting low copy nucleic acids of interest in a sample. In one method, a sample comprising a nucleic acid of interest is aliquotted into a plurality of reaction mixtures, at least two of which are single-copy reaction mixtures. The reaction mixtures are subjected to one or... Agent: Caliper Life Sciences, Inc.

20080090240 - Neisseria gonorrhoeae specific oligonucleotide sequences: The present invention relates to oligonucleotide sequences for amplification primers and detection probes and their use in nucleic acid amplification methods for the selective and specific detection of Neisseria gonorrhoeae in biological samples. The invention also provides oligonucleotide primer sets and primer/probe sets in the form of kits for the... Agent: Siemens Corporation Intellectual Property Department

20080090242 - Panel of biomarkers for prediction of fti efficacy: The present invention provides, inter alia, methods for selecting a patient with cancer for treatment with a farnesyl protein transferase inhibitor as well as methods for treating said patient.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20080090243 - Pseudo-tissues and uses thereof: The invention provides compositions and methods useful in the analysis of tissues and cells. More specifically, the invention provides compositions, referred to as “pseudo-tissue samples,” which comprise aggregated fixed cells embedded in an embedding medium. The invention also provides histological specimens comprising pseudo-tissues, as well as histological specimen-substrate compositions, such... Agent: Invitrogen Corporation C/o Intellevate

20080090239 - Rare cell analysis using sample splitting and dna tags: Described herein are methods to diagnose or prognose cancer in a subject by enriching, detecting, and analyzing individual rare cells, e.g., epithelial cells, in a sample from the subject. Also described are methods for labeling regions of genomic DNA in individual cells in said mixed sample with different labels wherein... Agent: Wilson Sonsini Goodrich & Rosati

20080090251 - Assays for superantigens: The present invention provides a superantigen quality control assay, particularly for SEA-E120, comprising incubating a standard amount of a superantigen-containing test sample with a standard amount of a soluble TCR which binds the superantigen, separating unbound TCR from the resultant superantigen/TCR-containing sample, quantifying the TCR bound in that sample, and... Agent: Banner & Witcoff, Ltd.

20080090252 - Detecting a bacterial process in chronic rhinosinusitis: The present invention provides a method for identifying bacterial induced rhinosinusitis. The method comprises obtaining a nasal or paranasal mucus sample and detecting the presence of neutrophil degranulation in the mucus sample. Degranulation of neutrophils can be determined by morphological analysis of the cells in the mucus or by detection... Agent: Hodgson Russ LLP The Guaranty Building

20080090253 - Membrane-based lateral flow assay devices that utilize phosphorescent detection: A lateral flow, membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes phosphorescence to detect the signals generated by excited phosphorescent labels. The labels may have a long emission lifetime so that background interference from many sources,... Agent: Dority & Manning, P.A.

20080090250 - Sets of digital antibodies directed against short epitopes, and methods using same: The present invention relates generally to sets of digital antibodies directed against short epitopes, and use thereof in methods for protein analysis.... Agent: Wilson Sonsini Goodrich & Rosati

20080090249 - Ube2g2 binding domain in the ubiquitin ligase gp78 and methods of use thereof: The present invention features isolated nucleic acid molecules, designated G2BD nucleic acid molecules, which encode the binding site from the gp78 ubiquitin ligase that binds to the Ube2G2 ubiquitin conjugating enzyme. The invention further provides isolated G2BD proteins and fusion proteins. Still further provided are diagnostic and therapeutic methods, as... Agent: Edwards Angell Palmer & Dodge LLP (client Reference No. 47992)

20080090254 - Method for assessing proliferation inhibiting effect of inhibitor, and method for determining sensitivity of tumor cell to inhibitor: A method for assessing the proliferation inhibiting effect of a receptor tyrosine kinase inhibitor is described. In the method, a cytoplasm is separated from a tumor cell to prepare a sample containing various receptor tyrosine kinases. The prepared sample is treated with the inhibitor. The receptor tyrosine kinases in the... Agent: Sughrue Mion, PLLC

20080090257 - Compositions and methods for inhibiting or inducing adipogenesis: This invention relates generally to compositions and methods which utilization nuclear receptors for regulating adipogenesis in cells. Specifically, the invention is directed to compositions which regulate transcription factor PPARγ and enhance or inhibit the transcription of genes responsible for directing cell differentiation towards a pathway of adipogenesis. More specifically, disclosed... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080090258 - Method and composition for diagnosing endometrial cancer: The present invention is related to methods and reagents for a multifactorial assay for the rapid, early detection of cancer and, more particularly, is related to a multimarker serological diagnostic test for early detection of endometrial cancer.... Agent: The Webb Law Firm, P.C.

20080090259 - Methods, devices, systems and computer program products for stochastic, competitive, force-based analyte detection: A cantilever array can be positioned adjacent a surface in the presence of a sample. The cantilever array includes a plurality of cantilevers having one member of a specific binding pair thereon. The surface includes the other member of a specific binding pair. Binding between the members of the binding... Agent: Myers Bigel Sibley & Sajovec

20080090260 - Substrates and assays for beta secretase activity: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.... Agent: Marshall, Gerstein & Borun LLP

20080090255 - Phosphoprotein detection reagent and method of making and using the same: A phosphoprotein detection reagent that selectively binds phosphoamino acids. Methods of generating and employing the reagent are also provided, as are methods of detecting modulation of protein phosphorylation are disclosed. Methods of detecting a change in state of a cell are also disclosed. Additionally, a kit for the detection of... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20080090261 - Method for the in vitro diagnosis of the exclusion of acute coronary syndromes: The present invention relates to a method for the in vitro diagnosis of the exclusion of acute coronary syndromes (ACS), consisting in associating the quantification of the concentration of at least one cardiac marker selected from troponin, CK-MB and myoglobin and the quantification of the concentration of D-dimers in a... Agent: Oliff & Berridge, PLC

20080090262 - Method to simultaneously detect different antibodies and antigens in clinical alimentary and environmental samples: Method to simultaneously detect different antibodies and antigens via immunoenzimatic tests and ELISA (Enzyme Linked ImmunoSorbent Assay) constituted by small absorbent cylinders, on which the immunocomplexes are formed, blocked at a modular distance on a probe; that carries a label to identify the sample under examination.... Agent: Smith Hopen, Pa

20080090265 - Method to assay coenzzyme q10 in blood plasma or blood serum: A method is described for determining CoQ10 concentrations in plasma samples. CoQ10 in the plasma sample is oxidized by treating the sample with an oxidizing agent having a redox potential higher than the redox potential of COQ10, such as, for example, para-benzoquinone. Following oxidation of the COQ10, the CoQ10 in... Agent: Mccarter & English LLP Cityplace I

20080090268 - Method for the diagnosis of helicobacter pylori infection, and a diagnostic kit for performing the method: m

20080090266 - Method of selecting a cardiomyoctye using intracellular mitochondria as an indicator: The invention relates to methods of selecting a cardiomyocyte from a cell population derived from a whole heart or a differentiated cell population derived from a stem cell without genetic alteration. Specifically, the invention relates to a method of selecting a cardiomyocyte from a cardiomyocyte-containing cell mixture without genetic alteration... Agent: Hunton & Williams LLP Intellectual Property Department

20080090269 - Compositions and methods for preparing specimens for microscopic analysis: Compositions and methods for preparing a biological specimen for microscopic analysis. Fixing compositions and dewatering compositions are provided with methods for their use that improve sample preparation and result in greater detail being available in the prepared specimen. Such compositions and methods also render more quantitative analysis of prepared specimens... Agent: Kirton And Mcconkie

20080090270 - Nogo receptor homologues and their use: This invention relates to gene polypeptides and polynucleotides that encode proteins of the Nogo-66 receptor (NgR) family and are therefore called NgR homologue 1 (NgRH1). The invention further relates to their use in identifying compounds that may be agonists or antagonists that are potentially useful in regeneration and protection of... Agent: Novartis Corporate Intellectual Property

20080090271 - Polypeptides having glucoamylase activity and polynucleotides encoding same: The present invention relates to polypeptides having glucoamylase activity and isolated polynucleotides encoding said polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. The invention also relates to the composition comprising a glucoamylase... Agent: Novozymes North America, Inc.

20080090272 - Metabolic engineering of amino acid production: The present invention is directed towards the fermentative production of amino acids, providing microorganisms, methods and processes useful therefor. Microorganisms of the invention are capable of converting glucose to amino acids other than L-isoleucine, L-leucine and L-valine with greater efficiency than the parent strain. The efficiency of conversion may be... Agent: Buchanan Ingersoll PC (archer Daniels Midland Company)

20080090273 - Malic acid production in recombinant yeast: We disclose a recombinant yeast, wherein the yeast is pyruvate decarboxylase enzyme (PDC) activity negative (PDC-negative) and is functionally transformed with a coding region encoding a pyruvate carboxylase enzyme (PYC) wherein the PYC is active in the cytosol, a coding region encoding a malate dehydrogenase enzyme (MDH) wherein the MDH... Agent: Williams, Morgan & Amerson

20080090274 - Process for the synthesis of (s)-1-(3,5-bis (trifluoromethyl)-phenyl-ethan-1-ol: The present invention is concerned with novel processes for the preparation of (S)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol (CAS # 30071-93-3). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.... Agent: Merck And Co., Inc

20080090275 - Method of concentrating and disrupting cells or viruses: Provided is a method for concentrating and disrupting cells or viruses, the method employs magnetic particles which are capable of binding the cells or viruses to capture the cells or viruses and a laser to disrupt the cells or viruses. Since the same particles are used in target cell separation... Agent: Sughrue Mion, PLLC

20080090276 - Heat-stable enzyme compositions: The thermal stability of enzymes is improved by incorporating the enzyme in a matrix of a non-reducing sugar, such as trehalose. Heat-stable compositions of enzymes and sugar are formed by adding the enzymes to a sugar syrup and drying the mixture either by spreading it on a carrier or by... Agent: Davis, Brown, Koehn, Shors & Roberts, P.C. The Financial Center

20080090277 - Nucleic acids and polypeptides involved in the production of cryptophycin: The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the invention to produce cryptophycins.... Agent: Fish & Richardson P.C.

20080090278 - Method for enhancing stability of a composition comprising soluble glucose dehydrogenase (gdh): The present invention relates to a method for enhancing stability of a composition comprising soluble glucose dehydrogenase (GDH). Soluble GDH is preferably FAD-dependent GDH derived from filamentous fungus, and the best effect is observed in FAD-GDH derived from A. oryzae or FAD-GDH derived from A. terreus. According to the invention,... Agent: Leydig Voit & Mayer, Ltd

20080090279 - Newly identified human small intestine extracellular lactase-phlorizin hydrolase (eclph) gene: The invention provides a transgenic animal producing low-lactose milk, which is transformed with a gene encoding an extracellular lactase-hydrolyzing enzyme cloned from a human small intestinal cDNA library. The invention also provides a new extracellular lactase-phlorizin hydrolase (ecLPH) gene that can express human lactase-hydrolyzing enzyme in the mammary gland of... Agent: Panitch Schwarze Belisario & Nadel LLP

20080090280 - Polypeptides of botryospaeria rhodina: The invention relates to functional polypeptides secreted from Botryospaeria rhodina CBS 247.96.... Agent: Novozymes North America, Inc.

20080090281 - Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use: A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.... Agent: Howson And Howson

20080090282 - Use of cell surface displays in yeast cell catalyst supports: Methods and compositions for providing novel catalyst supports are included herein. In one embodiment, included herein are yeast cell supports including one or more receptor proteins uniformly displayed on the surface of a yeast cell having the species Saccharomyces cerevisiae. Each receptor protein is anchored to a ligand that is... Agent: Buchanan Ingersoll PC (archer Daniels Midland Company)

20080090283 - Ethanol resistant and furfural resistant strains of e. coli fbr5 for production of ethanol from cellulosic biomass: Ethanol and furfural challenged strains of E. coli FBR5 exhibiting higher ethanol yield, productivity, and tolerance to both ethanol and furfural than FBR5 and methods for producing same.... Agent: John F. Letchford

20080090284 - Photosynthetic oil production with high carbon dioxide utilization: A system for processing oil from algae is disclosed. Specifically, the system recycles byproducts of the process for use as nutrients during algae growth and oil production. The system includes a conduit for growing algae and an algae separator that removes the algae from the conduit. Also, the system includes... Agent: Nydegger & Associates

20080090285 - Microbiological test device, assembly and method: The device for microbiological testing of a sample of liquid includes an envelope (11) and a filter membrane (3), said envelope (11) including a removable body (6) and means (4, 5) for supporting said membrane (3) in the wetted state; said supporting means (4, 5) including a sponge (5) and... Agent: Nields & Lemack

20080090286 - Mounting platform for biological growth plate scanner: The invention is directed to a biological scanner for scanning biological growth plates. A biological growth plate can be loaded into the biological scanner. Upon loading of a biological growth plate, the biological scanner generates an image of the plate and may perform an analysis of the image. Various embodiments... Agent: 3m Innovative Properties Company

20080090287 - Culture dish for culturing biological cells: A culture dish (1) comprising a basic structure (2) with a number of macro wells (4) for culturing oocytes and embryos, the culture dish further comprising a lid (3) with a movable part (8), the movable part (8) having an opening (11) adapted to the size of the macro wells... Agent: James C. Wray

20080090288 - Culture treatment apparatus and automatic culture apparatus: Contamination into other culture containers by airborne matter which had been spattered when a predetermined treatment is performed on a specimen in a culture container is prevented. There is provided a culture treatment apparatus comprising: a treatment chamber in which is stored a treatment device (19) which opens a lid... Agent: Scully, Scott, Murphy & Presser, P.C.

20080090289 - Microbial sampling device: A method and apparatus for sampling microorganisms using fluid pressure, vacuum or a combination thereof to create fluid flow that collects biological and chemical material on a filter element. The filter element is secured in a cartridge replaceably coupled to a hand-held sample collection device that provides a fluid drain... Agent: Streets & Steele

20080090290 - Nucleic acids encoding anti-il-12 antibodies, and methods of production: Isolated nucleic acids encoding an anti-IL-12 antibody or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders.... Agent: Philip S. Johnson Johnson & Johnson

20080090291 - Synthetic nucleic acid molecule compositions and methods of preparation: A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell.... Agent: Schwegman, Lundberg, Woessener & Kluth, P.A.

20080090292 - Tissue engineering in vivo with vascularized scaffolds: The field of the present invention relates to a novel method for producing tissue or organ in a mammal by implanting in vivo a novel three dimensional biodegradable scaffold. The novel three dimensional biodegradable scaffolds overcome the barrier of developing large organs with tissue engineering.... Agent: Craig A. Crandall, Apc

20080090293 - Methods of protecting plants from pathogenic fungi and nematodes: Methods for protecting a plant from a pathogen, particularly a pathogenic fungus or nematode, are provided. A method for enhancing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to... Agent: Pioneer Hi-bred International, Inc.

20080090294 - Methods of protecting plants from pathogenic fungi and nematodes: Methods for protecting a plant from a pathogen, particularly a pathogenic fungus or nematode, are provided. A method for enhancing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to... Agent: Pioneer Hi-bred International, Inc.

20080085506 - Automated, field-portable system for conducting toxicity measurements in water, soils, and sediments: A system for testing the toxicity of a test sample comprising: an aqueous suspension of dinoflagellates; a test chamber configured to contain the aqueous suspension of dinoflagellates and the test sample; an optical signal generator configured to emit an excitation signal for exciting the dinoflagellates to emit a fluorescence signal... Agent: Office Of Patent Counsel

20080085505 - Method for stimulation of bioluminescent organisms via turbulence created by gas bubbles: A method for stimulating bioluminescent organisms comprising the steps of forming gas bubbles in an aqueous suspension comprising the bioluminescent organisms; stimulating the bioluminescent organisms with the gas bubbles; and then measuring a characteristic of light emitted by the stimulated bioluminescent organisms.... Agent: Office Of Patent Counsel

20080085504 - System and method for quantifying toxicity in water, soil, and sediments: A toxicity test system comprising an aqueous suspension of dinoflagellates; a test chamber capable of containing the aqueous suspension and a test sample; an optical signal generator capable of emitting an excitation signal, which is capable of exciting the dinoflagellates to emit a fluorescence signal if the dinoflagellates are alive;... Agent: Office Of Patent Counsel

20080085507 - System for rapid analysis of glycated proteinaceous species in biological samples: A device is described which provides an automated or manual means to perform chromatographic affinity-based A1c analyses of whole blood or hemolysates in less than 1 minute. Further, such applications are useful for the quantitation of glycated plasma proteins used in analysis of gestational diabetes. The device includes several modules... Agent: Lathrop & Gage Lc

20080085512 - Array assay devices and methods for making and using the same: Aspects of the invention include methods for producing a backing element for use in an array assay device. An embodiment of the invention includes providing a precursor backing element, e.g., a solid support having a fluid retaining structure on a planar surface thereof, subjecting the precursor backing element to a... Agent: Agilent Technologies Inc.

20080085510 - Human ron-related gene variant associated with cancers: The invention relates to the nucleic acid and polypeptide sequences of three novel human Ron-related gene variants (Ron-V1, Ron-V2, and Ron-V3). The invention also provides a process for producing the polypeptides of the variants, as well as uses for the nucleic acid, polypeptide and antibodies to same in diagnosing human... Agent: Baker & Mckenzie LLP

20080085513 - In situ nucleic acid array synthesis compositions: In situ nucleic acid synthesis compositions are provided. The compositions include a solvent; and at least one of: a viscosity modifier; and a surface tension modifier. During use, the compositions further include one of a phosphoramidite and an activator. Also provide are methods of using the compositions, e.g., in the... Agent: Agilent Technologies Inc.

20080085514 - Methods and devices for array synthesis: Aspects of the invention include methods of fabricating an array. In an embodiment of the invention, a dry gas is vertically directed onto a solid support surface prior to deposition of a fluid reagent on a surface of the support. Also provided are devices and systems for practicing the methods.... Agent: Agilent Technologies Inc.

20080085511 - Preparation of biopolymer arrays: Methods and apparatus are disclosed for preparing an array of biopolymer features on a substrate by initiating multiple cycles of drop deposition of biopolymer forming reagents to feature locations on the surface of the substrate. Each cycle comprises at least one step of deposition of biopolymer monomers or biopolymer subunits.... Agent: Agilent Technologies Inc.

20080085509 - Single copy genomic hybridization probes and method of generating same: Nucleic acid (e.g., DNA) hybridization probes are described which comprise a labeled, single copy nucleic acid which hybridizes to a deduced single copy sequence interval in target nucleic acid of known sequence. The probes, which are essentially free of repetitive sequences, can be used in hybridization analyses without adding repetitive... Agent: Tracey S. Truitt Erickson & Kleypas, L.l.c.

20080085533 - Method and apparatus for non -invasive rinse diagnosis and monitoring of periodontal diseases: An assay test kit is used in a mouth rinse sample collection procedure involving collecting a mouth rinse sample from a patient. A neutrophil reactant diagnostic reagent is delivered to the rinse sample immediately after collection. Diagnostic reagents containing diammonium salts that are reactive with neutrophil enzymes are added to... Agent: Riches, Mckenzie & Herbert, LLP

20080085534 - Preparation of retinyl esters: Long-chain esters of retinol are prepared via a chemoenzymatic process from short-chain retinyl esters and an appropriate long-chain acid or ester in the presence of an enzyme. Use of various additives enhance the yield of the desired ester and facilitated its purification.... Agent: Brett L. Nelson Eastman Chemical Company

20080085535 - Stable genomic integration of multiple polynucleotide copies: Methods of constructing a cell comprising in its chromosome one or more copies of an open reading frame (ORF) or operon encoding at least one polypeptide of interest, each copy being under the transcriptional control of a heterologous promoter using a site specific recombinase and in vivo integration by recombination;... Agent: Novozymes North America, Inc.

20080085539 - Methods of generation and use of in vivo biotinylated recombinant antibodies: The present invention provides compositions and methods for generating in vivo biotinylated, secreted recombinant polypeptides comprising recombinantly co-expressing in a yeast cell (a) a secreted recombinant polypeptide comprising a biotin accepting site; and (b) a biotin ligase fused to the golgi localization domain so that the biotin ligase is localized... Agent: Christensen, O'connor, Johnson, Kindness, Pllc

20080085541 - Rapid reverse transcription of rna: Methods and kits for use in the practice of reverse transcriptase and for one-tube practice of reverse transcriptase and polymerase chain reaction are described. Use of an RNA template having a known conserved area of at least about 40 base pairs, a reverse transcription primer suitable for preparing DNA from... Agent: Holme Roberts & Owen, LLP

20080085508 - Non-nucleic acid based biobarcode assay for detection of biological materials: The present invention relates to screening methods, compositions, and kits for detecting for the presence or absence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes non-nucleic acid reporter markers as biochemical barcodes for detecting multiple protein... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080085518 - Assay device of xpd/ercc2 gene polymorphisms for the correct administration of chemotherapy in lung cancer: The invention is encompassed in the technical sector of lung cancer treatment with antitumor drugs, and it specifically develops a diagnostic device which allows treating each patient with the most effective drug according to the polymorphism they show for the XPD gene. The assay device of the invention is, based... Agent: Ladas & Parry LLP

20080085519 - Chemo-sensitivity assays using tumor cells exhibiting persistent phenotypic characteristics: The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring the progression of an individual patient malignancy. The assays, methods, tools and systems discussed herein represent an improved and unified system for monitoring and for identifying cellular and secreted markers, for screening cells to... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080085515 - Identification of multiple biological (micro) organisms by detection of their nucleotide sequences on arrays: The present invention is related to a method for identifying and/or quantifying an organism or part of an organism in a sample by detecting a nucleotide sequence specific for said organism, among at least 4 other nucleotide sequences from other organisms or from parts of the organisms. The method includes... Agent: Knobbe Martens Olson & Bear LLP

20080085522 - Meat analysis technique: A method of determining the source of a component part of a multi-source comminuted meat product. The method comprising the steps of providing a sample of said meat product, isolating from said meat product a meat component substantially derived from a single source animal, analysing said isolated meat component to... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20080085516 - Obesity gene and use thereof: The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human obesity and diabetes predisposing gene, specifically the TBC1D1 gene, some mutant alleles of which cause susceptibility to obesity and/or diabetes. More specifically, the... Agent: Myriad Genetics Inc. Intellecutal Property Department

20080085520 - Production and secretion of glucose in photosynthetic prokaryotes (cyanobacteria): The present invention includes compositions and methods for making and using an isolated cyanobacterium that includes a portion of an exogenous bacterial cellulose operon sufficient to express bacterial cellulose, whereby the cyanobacterium produces extracellular glucose. The compositions and methods of the present invention may be used as a new global... Agent: Chalker Flores, LLP

20080085521 - Single molecule amplificaton and detection of dna length: Methods and systems for performing single molecule amplification for detection, quantification and statistical analysis of nucleic acids are provided. Methods and systems are provided for determining and quantifying lengths of nucleic acids of interest.... Agent: Caliper Life Sciences, Inc.

20080085517 - Use of haploid genomes for genetic diagnosis, modification and multiplication: Methods for propagating haploid genomes of male or female origina and genetic screening and modification thereof are provided. These haploid genomes may be used to produce haploid embryos, and embryonic stem-like cells and differentiated cells. Also, these haploid genomes and cells containing, may be used as nuclear transfer donors to... Agent: Ropes & Gray LLP Patent Docketing 39/361

20080085523 - Method and device for trichomonas detection: A method and kit for detecting Trichomonas vaginalis infection in a human subject are disclosed. In the method, a body-fluid sample such as a vaginal-swab sample or urine is obtained from the subject and contacted with an antibody specific against a Trichomonas adhesin peptide, forming an antibody-adhesin peptide complex if... Agent: Myers Bigel Sibley & Sajovec

20080085524 - Methods for diagnosing irritable bowel syndrome: The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with irritable bowel syndrome (IBS). In particular, the present invention is useful for classifying a sample from an individual as an IBS sample using a statistical algorithm and/or empirical data. The... Agent: Townsend And Townsend And Crew, LLP

20080085525 - Chromatographic analysis devices and test kits: Chromatographic analysis devices (1) are described for the detection of blood parameters, consisting of cell components of cells circulating in blood of human or animal origin, or of plasma components, in a sample of a bodily fluid containing such cells, comprising a strip-shaped chromatographic medium (3) having a sample application... Agent: Troutman Sanders LLP

20080085526 - Clinical diagnosis of hepatic fibrosis using a novel panel of human serum protein biomarkers: The inventors have proposed a novel panel of human serum protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Serum from patients with varying degrees of hepatic scarring... Agent: Foley And Lardner LLP Suite 500

20080085527 - Method for measuring urea: Luminescence-based recipes for the measurement of creatinine, urea, uric acid, or glucose, and device using the same are provided.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20080085528 - Glucokinase activity assays for measuring kinetic and activation parameters: The subject matter disclosed and claimed herein relates to novel in vitro assays for measuring glucokinase activity and use of these assays for identifying modulators of glucokinase.... Agent: Louis J. Wille Bristol-myers Squibb Company

20080085530 - Ex vivo method for determination of cetp activity and efficacy of heart disease treatment: The present invention relates to a novel method to determine CETP activity in a bodily fluid sample wherein the sample may contain an inhibitor of CETP activity. The effect of the inhibitor is preserved to provide a more accurate determination of CETP activity in the fluid. Kits for the practice... Agent: Morrison & Foerster LLP

20080085529 - Fluorescence assay for kinase activity: The present invention provides a sensor and methods for determining kinase activity.... Agent: Timothy Oyer Wolf, Greenfield & Sacks

20080085531 - Antagonistic anti-human cd40 monoclonal antibody: The present invention provides novel antagonistic anti-human CD40 monoclonal antibodies, methods for generating them and uses thereof.... Agent: Hoffmann & Baron, LLP

20080085532 - Method for determining the immune status of a subject: The present invention is a method for using levels of soluble Clusters of Differentiation (CD) proteins, or cell surface-localized CD proteins extracted from T lymphocytes for determining the immune status of a subject. The present invention also a kit containing a CD protein extraction means and at least one antibody... Agent: Jane Massey Licata Licata & Tyrrell P.c.

20080085536 - Production of cellulose in halophilic photosynthetic prokaryotes (cyanobacteria): The present invention includes compositions and methods for making and using halophilic cyanobacterium comprising a spontaneous mutation causing constitutive cellulose biosynthesis, whereby the cyanobacterium is capable of producing cellulose in brine. The compositions and methods of the present invention may be used as a new global crop for the manufacture... Agent: Chalker Flores, LLP

20080085537 - Selection of host cells expressing protein at high levels: The invention provides a DNA molecule comprising a multicistronic transcription unit coding for i) a polypeptide of interest, and for ii) a selectable marker polypeptide functional in a eukaryotic host cell, wherein the polypeptide of interest has a translation initiation sequence separate from that of the selectable marker polypeptide, and... Agent: Trask Britt

20080085538 - Methods for expression and purification of recombinant human growth hormone: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080085540 - Method of engineering a cytidine monophosphate-sialic acid synthetic pathway in fungi and yeast: The present invention provides methods for generating CMP-sialic acid in a non-human host which lacks endogenous CMP-Sialic by providing the host with enzymes involved in CMP-sialic acid synthesis from a bacterial, mammalian or hybrid CMP-sialic acid biosynthetic pathway. Novel fungal hosts expressing a CMP-sialic acid biosynthetic pathway for the production... Agent: Merck And Co., Inc

20080085542 - Method for the preparation of mycophenolate mofetil by enzymatic tranesterification: The present invention relates to a process for the preparation of mycophenolate mofetil (MMF) in which an ester of mycophenolic acid (MPA) with a low-molecular-weight aliphatic alcohol is transesterified with N-(2-hydroxyethyl)morpholine in the presence of Candida antarctica lipase, and in which the MPA esterification reaction is carried out in the... Agent: The Firm Of Hueschen And Sage

20080085543 - Process for gibberellic acid production with \"fusarium moniliforme\" strains: The present invention provides an improved process for the production of gibberellic acid (GA3), achieving a yield over 225 g/kg of GA3 with solid substrate fermentation, and over 15 g/L by submerged fermentation. The method also provides novel substrates, including the use of Jatropha seed cake. The present invention has... Agent: Foley And Lardner LLP Suite 500

20080085544 - Artificial blood vessel and method for manufacturing thereof: An artificial tissue capable of carrying necessary nutrients for maintaining activities of cells and tissues, and a method of manufacturing an artificial blood vessel. A plurality of forms of blood vessels are extracted from an image of a living tissue and made into a blood vessel form image. Each of... Agent: Ladas & Parry LLP

20080085545 - Compositions comprising viruses and methods for concentrating virus preparations: A composition is disclosed comprising virus in a formulation comprising a polyhydroxy hydrocarbon buffered to maintain a pH in a range from about 7 to about 8.5 at a temperature in the range from about 2° C. to 27° C. Methods for concentrating and purifying virus preparations are also disclosed.... Agent: Townsend And Townsend And Crew, LLP

20080085546 - Compositions comprising organic matter and microorganisms and methods of using same: A composition comprising an organic component and a biological component wherein the organic component comprises a brix of equal to or greater than about 75%. A composition comprising an organic component, a biological component and water wherein the organic component comprises a brix of equal to or greater than about... Agent: Conley Rose, P.c. David A. Rose

20080085547 - Biofilter media and systems and methods of using same to remove odour causing compounds from waste gas streams: The present invention relates to biofilter systems and the biofilter media employed in such systems, as well as, methods of using same to remove odour causing compounds from waste gas streams. The biofilter media has a plurality of expanded glass granules. Each expanded glass granule has a coating thereon. The... Agent: Fasken Martineau Dumoulin LLP

20080085548 - Transporting arrangement for transporting biomass in a fermenter for generating biogas, and large-scale fermenter for generating biogas from biomass: The invention provides a transporting arrangement for transporting biomass (22), in particular biomass from energy crops, in a fermenter (2) for generating biogas, it being possible for large-scale fermenters (2) to be operated continuously, in accordance with the principle of the methanation of solid matter, by means of this transporting... Agent: Morrison & Foerster, LLP

20080085549 - Apparatus and method for providing live dinoflagellates for toxicity tests: A cartridge comprising: a container having a lower end; an aqueous suspension of dinoflagellates contained in the container; a gas port operatively coupled to the container, the port capable of directing a gas into the aqueous suspension in the lower end of the container; a gas vent operatively coupled to... Agent: Co - Spawarsyscen Sdo Office Of Patent Counsel

20080085550 - Apparatus and method for tracking a molecule or particle in three dimensions: An apparatus and method were used to track the movement of fluorescent particles in three dimensions. Control software was used with the apparatus to implement a tracking algorithm for tracking the motion of the individual particles in glycerol/water mixtures. Monte Carlo simulations suggest that the tracking algorithms in combination with... Agent: Los Alamos National Security, Llc

20080085551 - Microfluidic biochip for blood typing based on agglutination reaction: The present invention is directed to a microfluidic biochip based on an agglutination reaction that is frequently used in qualitative typing in the diagnostic medicine field by realizing a specimen inlet, a reagent inlet, a split microchannel, transfer microchannels, a chaos micromixer, a reaction microchamber, a microfilter, a passive microvalve,... Agent: Marshall, Gerstein & Borun LLP

20080085552 - Systems and methods for measurement optimization: The invention relates to methods and systems for detecting and or analyzing an agent in a sample with a chip having optical components incorporated therein.... Agent: Wolf Greenfield & Sacks, P.c.

20080085553 - Dna modular cloning vector plasmids and methods for their use: A group of modular cloning vector plasmids for the synthesis of a transgene or other complicated DNA construct, by providing a backbone having docking points therein, for the purpose of gene expression or analysis of gene expression. The invention is useful for assembling a variety of DNA fragments into a... Agent: Sughrue Mion, Pllc

20080085554 - Culture medium for culturing feeder cells for embryonic stem cells culture and the prepared feeder cells: A culture medium for preparation of feeder cells for embryonic stem cells, which can efficiently establish feeder cells for use in culture of embryonic stem cells including human's from limited donor-derived materials and culture them in a condition of a reduced risk of infection, is provided. Further, a preparation method... Agent: Kilyk & Bowersox, P.l.l.c.

20080085555 - Method for in vitro amplification of adult stem cells: The present invention provides a method of efficiently expanding non-adhesive adult stem cells in vitro. More specifically, the present invention provides a method of expanding non-adhesive adult stem cells, comprising culturing non-adhesive adult stem cells in the co-presence of adhesive feeder cells and non-adhesive non-stem cells in serum-free medium, wherein... Agent: Wenderoth, Lind & Ponack, L.l.p.

20080085556 - Culture device: A device for use in culturing a cell is provided. The device comprises at least one cell culture chamber and a fluid reservoir. The cell culture chamber has a tapered side wall and is in fluid connection with the fluid reservoir via a fluid path which is connected to the... Agent: Brinks Hofer Gilson & Lione/chicago/cook

20080085557 - Human cancer stem cell culture compositions comprising erbb2 variants and methods of use thereof: The present invention provides compositions and methods for the culture and maintenance of cancer stem cells. More particularly, the present invention provides the identification of cancer stem cell specific markers and methods of recognizing the same for the detection of tumors, for facilitating the prognosis of a patient with a... Agent: Sutherland Asbill & Brennan LLP

20080085558 - Process for chromosomal integration and dna sequence replacement in clostridia: The present invention is related to a new method for replacing or deleting DNA sequences in Clostridia, with high efficiency, easy to perform and applicable at an industrial level. This method is useful to modify several genetic loci in Clostridia in a routine manner. This method is based on a... Agent: Womble Carlyle Sandridge & Rice, Pllc

20080081323 - Regenerative medicine devices and melt-blown methods of manufacture: The invention relates generally to devices for organ replacement and regenerative medicine providing a biocompatible and biodegradable scaffold capable of integral cell growth that forms a hollow chamber, as well as methods for producing such devices by melt-blowing a web of flexible, polymer fibers in the presence of a porogen... Agent: Philip S. Johnson Johnson & Johnson

20080081325 - Modulation ratio determination with accommodation of uncertainty: Embodiments of the present invention relate to a system and method for detecting a blood characteristic in a patient. Embodiments of the present invention may comprise detecting a first modulating signal at a first wavelength, detecting a second modulating signal at a second wavelength, and determining a relative amplitude of... Agent: CovidienIPCounsel - Respiratory & Monitoring Solutions

20080081326 - Methods and devices for diagnostic testing: Methods, devices and apparatus are disclosed for analyzing a sample for the presence of one or more analytes. A sample is contacted with a well comprising a plurality of p-n junction nanowire pairs. One member of the nanowire pair comprises a capture moiety, and one member of the nanowire pair... Agent: Agilent Technologies Inc.

20080081329 - Electrochemical detection of substrates: The present invention provides a method for detecting probe-target substrate binding. In particular, the present invention provides a method for detecting a surface bound target complex by detecting the redox reaction of a redox transition metal complex that is catalyzed by a redox-catalyst complex.... Agent: Faegre & Benson LLP Patent Docketing

20080081330 - Method and devices for analyzing small rna molecules: The instant inventon provides methods and devices for detecting, enumerating and/or identifying small RNA molecules using single molecule sequencing techniques.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080081331 - Method and system for displaying genetic and genealogical data: A method and system for displaying genetic and genealogical data includes displaying indicators of related individuals. At least one genetically related individual is identified from a genetic database in response to a genetic input of an inquiring individual. Indicators of the inquiring individual and each of the at least one... Agent: Trask Britt

20080081332 - Methods and devices for conducting diagnostic testing: The present invention is directed to methods and apparatus for analyzing a sample for the presence of one or more analytes. The sample is contacted with a channel comprising (i) a plurality of features wherein each of the features comprises a binding partner for one of the respective analytes and... Agent: Agilent Technologies Inc.

20080081342 - Biomarkers for peripheral artery disease: This invention provides biomarkers whose concentrations in blood plasma are associated with the presence or absence of PAD in the patient from whom the plasma sample is taken. The invention also provides biomarkers for distinguishing between PAD patients who are long claudicators and PAD patients who are not. In addition,... Agent: Townsend And Townsend And Crew, LLP

20080081343 - Differential labeling for quantitative analysis of complex protein mixtures: The disclosed subject matter relates to a method of simultaneously identifying and determining the levels of expression of cysteine-containing proteins in normal and perturbed cells, a method for determining peptide expression levels between a first biological sample and a second biological sample, and a method for quantitative proteomic analysis of... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20080081340 - Enzymatic and chemical method for increased peptide detection sensitivity using surface enhanced raman scattering (sers): The sensitivity of surface enhanced Raman spectroscopy to silver nano-particle/peptide aggregates is increased by prior treatment of the peptides. According to a first type of embodiment, an enzyme such as Glu-C is used for protein(s) digestion based on the enzyme's ability to cleave proteins at a selected location having a... Agent: Intel Corporation C/o Darby & Darby P.C.

20080081341 - Immunoassay test device and method of use: Disclosed is a diagnostic testing device that may be used to detect one or more analytes in a sample. The device comprises a receptacle and a holder for a test strip. The test strip may be, for example, a lateral flow test strip. The device and holder permit analysis of... Agent: Frost Brown Todd LLC

20080081346 - Therapeutic and diagnostic methods and compositions targeting 4ig-b7-h3 and its counterpart nk cell receptor: The present invention relates to the identification of 4Ig-B7-H3 protein as a tumor associated molecule that imparts protection from NK cell-mediated lysis via a 4Ig-B7-H3 receptor on NK cells. The invention provides compounds that interfere with interactions between the 4Ig-B7-H3 protein and its receptor that can be used to potentiate... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080081349 - Isotopically labeled trapping agent and method for identifying reactive metabolites: The present invention is directed to an isotopically labeled trapping agent, methods for detecting reactive metabolites and methods of identifying drug candidates. More specifically, the isotopically labeled trapping agent and methods for detecting reactive metabolites may be used to detect both “hard” and “soft” reactive metabolites, thereby eliminating false positives.... Agent: Philip S. Johnson Johnson & Johnson

20080081354 - Devices, vectors and methods for inducible ischemia cardioprotection: Vectors, systems having implantable devices and methods useful to detect or treat ischemia are provided.... Agent: Schwegman, Lundberg & Woessner, P.A.

20080081353 - Production of recombinant human collagen: Methods, reagents (e.g. vectors) and host cells for the recombinant production of collagen are described, relating to the recombinant expression of a subunit of a collagen or procollagen and a collagen post-translational enzyme or subunit thereof.... Agent: Goudreau Gage Dubuc

20080081352 - Recombinant microorganism: The present invention provides a recombinant microorganism obtained by transferring, into a host microorganism which is capable of producing protein or polypeptide with increased productivity and which was identified by the present inventors, a gene encoding a protein or polypeptide, and a method for producing a protein or polypeptide by... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080081324 - Two-phase oxygenated solution and method of use: A two-phase mixture is provided having a dissolved gas and a suspension of bubbles in a liquid. Methods for making, maintaining, and using the two-phase mixture are also provided. The gas molecules may be introduced into the liquid at a high velocity under elevated pressure to form a supersaturated solution... Agent: Dann, Dorfman, Herrell & Skillman

20080081328 - Compositions and methods for detecting hepatitis b virus: Compositions, methods and kits for detecting viral nucleic acids. Targets that can be detected in accordance with the invention include HBV and/or HIV-1 and/or HCV nucleic acids. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers that facilitate detection of very low levels of HBV nucleic... Agent: Gen Probe Incorporated

20080081327 - Method for using division arrested cells in screening assays: Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal transduction assays, and are especially useful in large scale, high throughput assays.... Agent: Invitrogen Corporation C/o Intellevate

20080081338 - Diagnostic method: The present invention concerns a method for the detection or monitoring of cancer using a biological sample selected from blood, plasma, serum, saliva, urine from an individual, said method comprising: (a) obtaining DNA from the said biological sample; (b) digesting the DNA sample with one or more methylation-sensitive restriction enzymes;... Agent: Clark & Elbing LLP

20080081337 - Insulin related transcription factor and uses thereof: The invention provides isolated mMafA polypeptides, nucleic acids, vectors and host cells containing them, which encode a novel insulin related transcription factor. Diagnostic methods, methods of selecting and differentiating insulin-producing cells, and methods of treatment utilizing compositions of the invention are also provided.... Agent: Fish & Richardson PC

20080081334 - Methods for diagnosis and pronostic of psychiatric diseases: The invention describes an in vitro method for detecting a psychiatric disorder occurring with psychosis selected from schizophrenia and bipolar disorder in an individual who has suffered a first psychotic episode, or for determining the state or severity of said disorder, or for monitoring the effect of a therapy administered... Agent: Moore & Van Allen PLLC

20080081333 - Methylated promoters as biomarkers of colon cancer: The present invention provides methods for identifying or assessing probabilities for having or developing an abnormal condition in subject and for the recurrence of the abnormal condition in the subject after receiving treatment. The method comprises determining the methylation status of at least the tachykinin-1 (TAC1) gene in the subject... Agent: Sughrue Mion, PLLC

20080081335 - Oligonucleotide probe/primer methods for polynucleotide detection: The invention is related to a labeled oligonucleotide pair for detecting a target nucleic acid and methods, kits and compositions containing the labeled oligonucleotide pair. The labeled oligonucleotide pair forms a complex comprising a nucleic acid primer and a nucleic acid probe.... Agent: Agilent Techologies Inc

20080081339 - Tumor associated markers in the diagnosis of prostate cancer: The invention is directed to tumor associated markers (TAMs) that can be used diagnostically, especially in the diagnosis of prostate cancer and other markers (BPHMs) that can be used in the diagnosis of benign prostate hyperplasia. It also includes glass or plastic plates or slides on which the TAMs or... Agent: Law Office Of Michael A. Sanzo, LLC

20080081336 - Variants of the serotonin transporter: Isolated SLC6A4 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described. Methods for determining whether a subject contains an SLC6A4 sequence variant also are provided.... Agent: Fish & Richardson P.C.

20080081344 - Cardiac troponin as an indicator of coronary artery disease: The present invention relates to a method for diagnosing an advanced ischemic coronary heart disease comprising the steps of determining an amount of a cardiac troponin in a sample of a subject and diagnosing the disease by comparing the amount determined with a reference amount of the cardiac troponin.... Agent: Roche Diagnostics Operations Inc.

20080081345 - Sour taste receptor compositions and methods: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste... Agent: Medlen & Carroll, LLP

20080081347 - Eia for monitoring legionella pneumophila presence in water samples: A qualitative and quantitative EIA for detecting L. pneumophila in water samples is disclosed. Critical to the disclosed levels of sensitivity of these EIA's is the use of antigen-specific antibodies to the target L. pneumophila antigen that have been rendered antigen-specific by affinity purification on a chromatographic column, which antibodies... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080081348 - Detection and monitoring of liver damage: A method of detecting liver damage in a subject comprises measuring the level of caspase-3 generated cytokeratin-18 fragments in the bodily sample. The level of measuring the level of caspase-3 generated cytokeratin-18 fragments is then correlated with liver disease progression.... Agent: Tarolli, Sundheim, Covell & Tummino L.L.P.

20080081350 - In vitro-differentiated retinal ganglion cells and method for producing same: In vitro-differentiated retinal ganglion cells can be produced by exposing a mammalian retinal ganglion cell line to a protein kinase inhibitor. The differentiated retinal ganglion cells can be used to identify agents that protect retinal ganglion cells in vivo or in vitro from cell injury (including cell death) and agents... Agent: Quarles & Brady LLP

20080081351 - Methods for processing cell block: A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection... Agent: VistaIPLaw Group LLP

20080081355 - Activatable recombinant neurotoxins: Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.... Agent: Allergan, Inc.

20080081356 - Production of glycoproteins: An improved system for large scale production of glycoproteins in cell culture is provided. In accordance with the present invention, cells expressing a glycoprotein are grown in media that contain manganese at a concentration of between approximately 10 and 600 nM. The use of such a system allows production of... Agent: Choate, Hall & Stewart LLP/wyeth

20080081357 - Method and apparatus for isolating nucleic acids from a cell using carbon nanotubes and silica beads: Provided herein are a method and an apparatus for isolating nucleic acids from cells. The method comprises introducing carbon nanotubes (CNTs) and silica beads into a solution containing the cells, irradiating the solution with a laser beam disrupt the cells releasing the nucleic acids from the disrupted cells, thereby binding... Agent: Cantor Colburn, LLP

20080081358 - Ethanol production in fermentation of mixed sugars containing xylose: Xylose-utilizing Z. mobilis strains were found to have improved ethanol production when grown in medium containing mixed sugars including xylose if sorbitol or mannitol was included in the medium. The effect was seen in concentrations of mixed sugars where no growth lag period occurs, as well as in higher sugars... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080081359 - Methods for producing mutant microbes useful for precious metal and bioenergy production: A mutant microbe that generates trace amounts of gold on silver, and uses of the mutant microbe for recovering precious metals and producing biofuels and oil products are described. According to an exemplary embodiment, the mutant microbe is produced by placing metallic silver in an aqueous solution, and adding a... Agent: Raymond Owyang

20080081360 - Erk2 crystals: The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20080081361 - Process for production of a recombinant protein and a fusion protein: This invention provides a recombinant protein expression system using a host and cell-free translation system, and is capable of universally expressing a large amount of any protein as soluble protein, while preventing toxicity in hosts, formation of inclusion bodies, and decompositions with proteases. Such may be achieved by expressing the... Agent: Sughrue Mion, PLLC

20080081362 - Multilayered composite for organ augmentation and repair: The present invention relates to devices and methods for tissue augmentation or regeneration and specifically, to a composite of bioabsorbable scaffold material and autologous tissue, suitable for implantation in tissue or organs.... Agent: Philip S. Johnson Johnson & Johnson

20080081363 - Cell block processing station: A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a collection well in communication with the collection... Agent: VistaIPLaw Group LLP

20080081364 - Preservation system for stratabound microorganisms: The present invention is directed towards a storage system for biologically viable aquatic microorganisms. The system includes substrate with hydrated and viable microorganisms attached thereto, and a packing material which envelops a volume of the substrate in a manner effective to preserve a degree of hydration necessary to maintain said... Agent: Mchale & Slavin, P.A.

20080081365 - Lentivirus vectors for gene transfer to alveolar epithelial cells: The present invention demonstrates that VSV-G-pseudotyped lentivirus vectors efficiently transduce AEC in primary culture and in vivo with transduction favored by virus application from the apical side. Transduction efficiency in AEC increased with increasing MOI and greatly exceeded that achieved with a similarly pseudotyped MLV retrovirus vector. The present invention... Agent: Bingham Mccutchen LLP

20080081366 - Polynucleotide composition, method of preparation, and use thereof: A lyophilized polynucleotide composition contains at least one polynucleotide and at least one cryoprotectant, wherein the ratio of the polynucleotide to cryoprotectant is from about 0.001 to about 1.0 part by weight polynucleotide per 1.0 part by weight of the cryoprotectant. This composition also contains from about 0.5 weight percent... Agent: Wyeth Patent Law Group

20080081368 - Method and apparatus that increases efficiency and reproducibility in immunohistochemistry and immunocytochemistry: A method combined with its necessary container package that facilitates unique processing of microscope slides in a reagent solution is disclosed. This invention has not been described elsewhere. The container package is a partitioned box with each compartment fitting one standard microscope slide. The slides are immersed in a staining... Agent: Anne Marie Bailey Lorne John Hofseth

20080081367 - Preparation of a cell concentrate from a physiological solution: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological... Agent: Fulbright & Jaworski, LLP

20080081369 - Method for chondrocyte expansion with phenotype retention: The present invention provides a method for expanding a population of chondrocytes that maintains chondrocyte phenotype during the expansion by culturing the population in a defined serum-free expansion medium containing one or more cytokines and under low attachment conditions. The method further solves diffusion problems during the subsequent stage of... Agent: Biotactica, LLC

20080081370 - Directed differentiation of human embryonic stem cells into mesenchymal/stromal cells: Methods for producing hESC-derived mesenchymal stromal/stem cells are disclosed. The cells produced are multipotent and can differentiate into the three mesenchymal cell lineage types and are characterized by cell-specific markers.... Agent: Quarles & Brady LLP

20080081371 - Low density spreading methods for somatic embryogenesis: In one aspect, the present invention provides methods of producing conifer cotyledonary somatic embryos from pre-cotyledonary embryos. The methods of this aspect of the invention include the step of (a) dispensing a plurality of pre-cotyledonary embryos onto a porous material horizontally disposed over a non-porous surface in a volume of... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

20080081372 - High-throughput cell transfection device and methods of using thereof: Transfecting biology cells with nucleic acid molecules (DNA, siRNA) is an essential prerequisite in elucidating how genes function in complex cellular context and how their activities could be modulated for therapeutic intervention. Traditionally studies are carried out on a low throughput gene-by-gene scale, which has created a huge bottleneck in... Agent: Rational Biotechnology Inc.

20080081373 - Genetic inhibition by double-stranded rna: A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of... Agent: Morgan Lewis & Bockius LLP