Chemistry: molecular biology and microbiology inventions 03/08

20080070231 - Genetically engineered biological indicator: The disclosed technology relates to a genetically engineered biological indicator, comprising: at least one test organism and at least one reporter gene suitable for producing an indicator enzyme, the reporter gene being taken up by the test organism; and at least one repressor gene that inhibits expression of the reporter... Agent: Renner Otto Boisselle & Sklar, LLP

20080070239 - Detection of neureopeptides associated with pelvic pain disorders and uses thereof: Diagnostic assessment and therapeutic treatment of pelvic pain disorders, including bladder disorders, bowel disorders, and/or reproductive tissue or organ disorders that are characterized by increased expression of the neuropeptides CGRP and/or PACAP. Additionally, applicants have developed a transgenic nonhuman model for pelvic pain disorders, where the transgenic animal expresses in... Agent: Nixon Peabody LLP - Patent Group

20080070243 - Gene expression profiling for identification, monitoring and treatment of multiple sclerosis: The present invention provides methods of characterizing multiple sclerosis pr inflammatory conditions associated with multiple sclerosis using gene expression profiling.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20080070241 - Kits for amplifying and detecting nucleic acid sequences: This invention provides novel processes for amplifying nucleic acid sequences of interest, including linear and non-linear amplification. In linear amplification, a single initial primer or nucleic acid construct is utilized to carry out the amplification process. In non-linear amplification, a first initial primer or nucleic acid construct is employed with... Agent: Enzo Biochem, Inc.

20080070238 - Method for the synthesizing nucleic acids, and application thereof: The invention relates to a method for synthesizing a nucleic acid comprising modified nucleotides. Said method encompasses the following steps: a matrix strand is provided; —a primer which at least partially hybridizes on the matrix strand is provided; —nucleoside triphosphates, at least some of which are modified nucleoside triphosphates, are... Agent: Bell, Boyd, & Lloyd LLP

20080070242 - Method for cancer detection and monitoring: The present invention provides for methods for detection of cancer or predisposition to cancer comprising detection of specific mutations in genomic DNA encoding the HAS1 protein. The present invention further provides for methods for monitoring of disease progression in a mammalian patient and novel therapeutic methodologies for treatment of disease.... Agent: Craig K Sherburne

20080070245 - Method for herd management of domestic ruminants to control infection due to mycobacterium avium subspecies paratuberculosis: A method of herd management of domestic animals contingent upon selective use and interpretation of nesting Map nesting PCR technology and resulting data, including qualitative and quantitative fecal screening for Map DNA, nesting Map PCR of milk, and establishing the criteria by which animals are moved constructively with in the... Agent: Gilles R. G. Monif, M.d.

20080070236 - Method for sequencing nucleic acid molecules: The sequence of a target polynucleotide can be determined by: (i) contacting the target polynucleotide with a polymerase enzyme and one of the nucleotides A, T(U), G, and C under conditions suitable for the polymerase reaction to proceed; (ii) measuring the time taken for the polymerase to bind to and... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080070250 - Method of removing air bubbles from hybridization solution of microarray-coverslip assembly and microarray kit for the same: A method of removing air bubbles from a hybridization solution in a microarray-coverslip assembly c including injecting a solution of magnetic particles between the coverslip and microarray, applying a magnetic field to the microarray-coverslip assembly, moving the magnetic particles and removing air bubbles in the hybridization solution from a hybridization... Agent: Cantor Colburn, LLP

20080070244 - Mold test kit: The present invention provides a simple and easy-to-use mold detection kit for determining the presence or absence of airborne mold spores in multiple locations within a structure. The invention also provides methods for using the kit.... Agent: Quarles & Brady LLP

20080070237 - Npas3 mutant mice and uses for screening and testing therapies for schizophrenia and related neurological disorders: A transgenic mouse with a gene-targeted mutation of the Npas3 gene, and a model of schizophrenia and related neurological disorders such as Obsessive-Compulsive Disorder, Tourette's Syndrome, and bipolar disorders, and other neurological disorders affecting locomotor activity, including Parkinson's Disease. A method is also provided for use of the Npas3-deficient mouse... Agent: Hasse & Nesbitt LLC

20080070247 - Physiogenomic method for predicting effects of exercise: The present invention relates to the use of genetic variants of associated marker genes to predict an individual's response to exercise. The present invention further relates to analytical assays and computational methods using the novel marker gene set. The present invention has utility for developing personalized fitness regimens to optimize... Agent: Morgan & Finnegan, L.L.P.

20080070246 - Recombinant protein and method of screening for agents that modulate polypeptide aggregation: e

20080070264 - Intracellular signaling-induced ret-independent gdnf receptor-effected morphological changes: The invention provides methods for identifying modulators of RETindependent, GDNF effected intracellular signaling. The invention further provides methods of identifying useful modulators of RET-independent GDNF receptoreffected MET activation, as well as modulators of morphological responses which are effected by nonRET GDNF receptor-effected intracellular signaling. Methods of distinguishing RET-independent GDNF ligand-mediated... Agent: Woodcock Washburn LLP

20080070272 - Sterilization indicator: The disclosed technology relates to a sterilization indicator and a process to concentrate signal generated by constraining it to a minimal surface, in a minimal volume and minimal pH and growth buffering or mediating influences. The sterilization indicator may comprise a carrier 12, the carrier having a first surface 14... Agent: Renner Otto Boisselle & Sklar, LLP

20080070279 - Group of synthetic antimicrobal peptides: A group of new synthetic antimicrobial peptides are disclosed, which demonstrate stronger bactericidal activity than native antimicrobial peptides. The present synthetic antimicrobial peptides can be produced by solid-phase chemical synthesis or gene expression and be used to prepare the medicines for treating the diseases induced by bacteria, viruses and fungi,... Agent: Wolf Greenfield & Sacks, P.C.

20080070229 - Method for preserving organs for transplantation: Methods and apparatus for preserving tissue such as harvested organs for transplant are described. A preferred method includes delivering to a harvested organ an effective amount of electromagnetic energy, the electromagnetic energy having a wavelength in the visible to near-infrared wavelength range, wherein delivering the effective amount of electromagnetic energy... Agent: Knobbe Martens Olson & Bear LLP

20080070230 - Methods for reducing or preventing liquid-liquid phase separation in high concentration protein solutions: Methods of formulating proteins at high concentrations in protein solutions, wherein the protein solutions lack or have reduced liquid-liquid phase separation are described. Such protein solutions are substantially clear and substantially homogenous. Additionally, methods of concentrating and purifying proteins using liquid-liquid phase separation are provided.... Agent: Wilmerhale/wyeth

20080070232 - Expression vectors containing a truncated epstein barr nuclear antigen 1 lacking the gly-gly-ala domain for enhanced transient gene expression: This invention relates to the unexpected discovery that nucleotide coding sequences coding for a truncated Epstein Barr Nuclear Antigen 1 (EBNA1t) protein (lacking the Gly-Gly-Ala domain), when in cells of mammalian origin, are associated with improved growth and increased transient gene expression when compared with cells expressing a complete EBNA1... Agent: Borden Ladner Gervais LLP Anne Kinsman

20080070234 - Measuring range extension of chromatographic rapid tests: A method for the quantitative determination of an analyte in a sample is provided comprising: (a) providing an analyte-specific substance which is able to undergo a reaction which generates a detectable signal when it is contacted with an analyte; (b) providing at least two calibration graphs which have been generated... Agent: Roche Diagnostics Operations Inc.

20080070233 - Quantitative analysis and typing of subcellular particles: A method for the determination and individual characterization of particles by means of at least two different detectable probes in a sample is proposed, wherein the particles, especially molecules or molecular aggregates, have at least one binding site, preferably a multitude of binding sites, for at least one of said... Agent: Jacobson Holman PLLC

20080070260 - Canola event pv-bngt04(rt73) and compositions and methods for detection thereof: The present invention provides assays for detecting the presence of the PV-BNGT04(RT73) canola event based on the DNA sequence of the recombinant construct inserted into the canola genome and of genomic sequences flanking the insertion site.... Agent: Howrey LLP

20080070252 - Chr and pomc effects on animal growth: The present invention provides for selection of bovine animals that will display phenotypes associated with increased rates of growth. These phenotypes include hot carcass weight, average daily gain, shipping weight, end of test rib eye area, and adjusted weaning weight which is a measure of post-natal growth, based on the... Agent: Heenan Blaikie LLP South Tower, Royal Bank Plaza, Suite 2600

20080070240 - Composition for deaminating dna and method of detecting methylated dna: (1) A sulfite composition having a sulfite concentration of more than 6.2 M, (2) a method for deaminating DNA using a sulfite composition described in (1), (3) a method for detecting methylated DNA using a sulfite composition described in (1), (4) a kit for deaminating DNA or for detecting methylated... Agent: Leydig Voit & Mayer, Ltd

20080070257 - High throughput screening assay for histone modifying enzyme modulators: The present invention provides a general method for identify agents that modulate the activity of histone modifying enzymes, such as an acetylase, deacetylase, methyltransferase, demethylase, kinase, etc. The assay the of invention employs reconstituted, immobilized nucleosomes and fluorescence-based assays, such as fluorescence-based immunoassays, scintillation proximity assays, or FRET assays to... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20080070235 - Method for recognizing acute generalized inflammatory conditions (sirs), sepsis, sepsis-like conditions and systemic infections: The present invention relates to a method for in vitro detection of SIRS, sepsis and/or sepsis-like conditions. This method renders the evaluation of the severity and/or the therapeutic progress of sepsis and severe infections, in particular sepsis-like systemic infections possible. Further, the present invention relates to the use of recombinantly... Agent: Akerman Senterfitt

20080070251 - Method of producing factor viii proteins by recombinant methods: Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked to a promoter, wherein the promoter is characterized by the ability to produce commercially viable Factor VIII protein; and incubating the... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20080070254 - Method of prognosis of metastasis by detection of fra12e fragile site within the smrt gene/locus at chromosome 12q24: Provided are methods for prognostic prediction of metastasis. The method comprises identifying the presence or absence of a fragile site FRA12E in 12q24 at the SMRT gene locus. The presence of FRA12E in an individual can be determined in cell samples obtained from an individual by hybridization techniques such as... Agent: Hodgson Russ LLP The Guaranty Building

20080070253 - Methods and products for in vitro genotyping: An in vitro method for genotyping genetic variations in a individual, and products for use in the method.... Agent: Speckman Law Group PLLC

20080070248 - Methods for predicting therapeutic response to agents acting on the growth hormone receptor: This invention relates to methods for predicting the magnitude of a subject's therapeutic response to agents that act on the growth hormone receptor. Preferred aspects include methods for increasing the height of human subjects having short stature, and for treating obesity and acromegaly.... Agent: Pharmacia Corporation Global Patent Department

20080070256 - Non-human animal models for b-cell non-hodgkin's lymphoma and uses thereof: Disclosed are non-human animal models, and preferably, rodent models, and more preferably, mouse models, of B-cell Non-Hodgkin's Lymphoma (NHL). In particular, the present invention provides animal models of B cell NHL including, B cell chronic lymphocytic leukemia/lymphoma (B-CLL), Burkitt's lymphoma (BL), Follicular-like lymphoma (FLL) and Diffuse large B-cell lymphoma (DLBCL),... Agent: Sheridan Ross PC

20080070249 - Novel activating agent of glucose uptake and a screening method therefor: An activating agent of glucose uptake comprising as an active ingredient a substance having a PGC-1β function; and a method of screening for an activating agent of glucose uptake, comprising the steps of bringing a substance to be tested into contact with a promoter of a PGC-1β gene and analyzing... Agent: Sughrue Mion, PLLC

20080070255 - Novel gene and uses therefor to modify pasture qualities of crops: The invention relates generally to isolated leucoanthocyanidin reductase LAR polypeptides of the Reductase-Epimerase-Dehydrogenase (RED) protein family, and nucleic acid molecules encoding same and their use in regulating the biosynthesis and accumulation of proanthocyanidins in plants. The invention is further directed to isolated nucleic acid molecules of plants which encode leucoanthocyanidin... Agent: John P. White Cooper & Dunham LLP

20080070259 - Novel human enzymes of the metalloprotease family: This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are useful in therapy, to antibodies specific to such peptides, and... Agent: Crowell & Moring LLP Intellectual Property Group

20080070258 - Polyamide nucleic acid derivatives and agents, and processes for preparing them: The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080070261 - Sulfenic acid-reactive compounds: wherein: R1 is a label (e.g., a detectable groups; an anti-tumor agent)s; L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. the compounds are useful for, among other things, identifying cysteine sulfenic... Agent: Myers Bigel Sibley & Sajovec

20080070262 - Method for detecting pathogens: The present invention relates generally to methods for detecting and identifying microorganisms and, more particularly, to methods for detecting microorganisms in a sample by incubating the sample at two temperatures to facilitate increased detection of the organism.... Agent: Seed Intellectual Property Law Group PLLC

20080070263 - Method for differentiation of alzheimer's disease into subgroups: A method for diagnosing distinct subgroups of Alzheimer's Disease, the method comprising the steps of obtaining a sample of cerebrospinal fluid and determining the level of ubiquitin, the level of Aβ1-42, and the level of tau present in the sample. Based on the levels of each composition in the cerebrospinal... Agent: Bond, Schoeneck & King, PLLC

20080070265 - Peptide-based immunization therapy for treatment of atherosclerosis: The present invention relates to a fragment of apolipoprotein B, for immunization for prophylactic or therapeutic treatment of mammals, including humans, against ischemic cardiovascular diseases, in particular myocardial infarction or stroke, as well as diagnosing the presence or absence of antibodies related to increased or decreased risk of developing ischemic... Agent: Gauthier & Connors, LLP

20080070266 - Fret-based apoptosis detector: The present invention relates to compositions comprising a FRET-based substrate, a cell-targeting moiety and a dendrimer, and methods for generating and using the same.... Agent: Casimir Jones, S.c.

20080070268 - Differential expression profiling analysis of cell culture phenotypes and the uses thereof: The present invention provides methods for systematically identifying genes and proteins and related pathways that maximize protein expression and secretion by expression profiling analysis. The present invention further provides methods for manipulating the identified genes and proteins to engineer improved cell lines.... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP (formerly Kirkpatrick & Lockhart Nicholson Graham)

20080070271 - Function homology screening: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis... Agent: Bozicevic, Field & Francis LLP

20080070270 - Methods and kits for testing the efficacy of therapeutic compounds and other therapies in a three-dimensional matrix with respect to tumorous cells and tissue: Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiological fibers, which are adapted and arranged to provide conditions which permit behaviors, such as the... Agent: Gary L. Shaffer

20080070267 - Modulation of neurotransmitter activity in neurons: The present invention relates generally to methods, devices and compositions for treating mental, neurological, and cognitive diseases related to deficiencies in the biosynthesis and/or metabolism of neurotransmitters.... Agent: Buchanan, Ingersoll & Rooney LLP

20080070269 - Three-dimensional physiological matrices for oncological testing, and methods for their production and use: Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiological fibers, which are adapted and arranged to provide conditions which permit behaviors, such as the... Agent: Gary L. Shaffer

20080070273 - Marine actinomycete taxon for drug and fermentation product discovery: The invention is the discovery of an actinomycete genus, given the name Salinospora gen. nov., that displays an obligate requirement of seawater (Na+) for growth and unique 16S rRNA signature nucleotides. The invention is also the use of the genus for the production and discovery of active biomolecules such as... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP

20080070274 - High capacity, methods for separation, purification, concentration, immobilization and synthesis of compounds and applications based thereupon: Compositions are provided herein comprising a base material having engrafted polymer brushes. The polymer brushes further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, which confer functional properties to the base material compositions. Methods of using these compositions include deoxygenation... Agent: Foley & Lardner LLP

20080070275 - Factor viii: remodeling and glycoconjugation of factor viii: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.... Agent: Morgan, Lewis & Bockius LLP (sf)

20080070277 - Homologous amds genes as selectable marker: The present invention relates to novel functional amdS genes from A. niger that can be used as dominant and bi-directional selection marker gene in the transformation of organisms. The present invention further relates to the production of a compound of interest in a fungal host cell transformed with the amdS... Agent: Nixon & Vanderhye, PC

20080070278 - Novel agent for controlling cell activity: This invention describes a novel agent for the targeted control of a mammalian cell activity, in particular the agent is used to control the interaction of particular cell types with their external environment. The agent has applications as a pharmaceutical for the treatment of a variety of disorders. An agent... Agent: Merchant & Gould PC

20080070276 - Transcriptional termination of transgene expression using host genomic terminators: The present invention relates to a method for expressing a transgene in a host cell that permits transcriptional termination of the transgene to occur without having to rely on a functional termination site in the DNA used for the transformation. Additional 3′ regulatory sequences and 3′ end processing enhancing sequences... Agent: Klarquist Sparkman, LLP

20080070280 - Product quality enhancement in mammalian cell culture processes for protein production: The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-galactose, preferably with feed medium containing D-galactose, preferably daily, to sustain a sialylation effective... Agent: Louis J. Wille Bristol-myers Squibb Company

20080070283 - Dna fragment amplification method, reaction apparatus for amplifying dna fragment and process for producing same: A reaction apparatus (10) includes a substrate (12) and a plurality of columnar members (14) formed on the substrate (12). Oligonucleotides for immobilization (16) having sequences complementary to sequences of both ends of a starting template DNA (18) is adhered on the surfaces of the substrate (12) and the columnar... Agent: Foley And Lardner LLP Suite 500

20080070282 - Method and device for obtaining or amplifying nucleic acid from a cell using a nonplanar solid substrate: The present invention relates to a method of isolating a nucleic acid from a microorganism cell. The method comprises contacting a nonplanar solid substrate with a cell-containing sample in a liquid medium having a pH of 3.0 to 6.0 so that the microorganism cell is bound to the nonplanar solid... Agent: Cantor Colburn, LLP

20080070281 - Method for stabilising reagents which are useful for nucleic acid amplification: A method for stabilising reagents suitable for use in a nucleic acid amplification reaction has now been developed comprising: (i) preparing a reagent mixture comprising reagents suitable for use in a nucleic acid amplification reaction wherein the mixture comprises a polynucleotide polymerase; and (ii) drying the reagents; characterised in that... Agent: Nixon & Vanderhye, PC

20080070284 - Oxidative, reductive, hydrolytic and other enzymatic systems for oxidizing, reducing, coating, coupling or cross-linking natural and artificial fiber materials, plastic materials or other natural or artificial monomer to polymer materials: The invention relates to methods for oxidizing (redox reactions, preferably pulp delignification/bleaching), for carrying out coupling reactions (grafting polymer materials) or for carrying out cross-linking reactions on natural (i.e. having natural origin) or artificial (i.e. synthetically produced polymers) monomers to polymers or of mixtures of natural and artificial polymers or... Agent: Bacon & Thomas, PLLC

20080070285 - Process for producing cmp-n-acetylneuraminic acid: A method by which high-purity CMP-N-acetylneuraminic acid (HPLC purity, 95% or higher), which has been difficult to obtain with any technique other than chromatography, can be easily obtained in satisfactory yield by a simple operation without the need of chromatography. The process, which is for producing high-purity CMP-N-acetylneuraminic acid (CMP-NeuAc),... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080070286 - Dna participating in hydroxylation of macrolide compound: The present invention provides a DNA participating in biological transformation of a macrolide compound 11107B. The present invention provides, particularly, a DNA participating in biological transformation of a macrolide compound 11107B represented by the formula (I) into a 16-position hydroxy macrolide compound 11107D represented by the formula (II), the DNA... Agent: Birch Stewart Kolasch & Birch

20080070287 - Variant polypeptides and methods of making: The present invention relates to a method for the production of a variant lipid acyltransferase comprising the steps of: (i) selecting a parent enzyme which is a lipid acyltranserase enzyme; (ii) modifying one or more amino acids to produce a variant lipid acyltransferase; (iii) testing the activity of the variant... Agent: Frommer Lawrence & Haug

20080070288 - Activator for a ferment based on lactic acid bacteria: The invention provides a ferment activator based on lactic acid bacteria, which comprises at least a nitrogenous substance, a buffer system capable of maintaining the pH for activity of the lactic acid bacteria with which said activator has to be combined at a value between 5 and 7, and which... Agent: Buchanan, Ingersoll & Rooney PC

20080070289 - Process for storing enriched nematodes: A process for preserving and storing nematodes having an increased feeding value for later use as needed in the feeding of aquaculture organisms. In this process, nematodes are enriched with an additive such as essential fatty acids, vaccines, hormones, immunostimulants, attractants, nutrients and pigments. Liposomes can serve as a medium... Agent: Dr. Mark M. Friedman C/o Bill Polkinghorn - Discovery Dispatch

20080070290 - Process for removing ammonia, odours and dust from ventilation air and apparatus for use in such a process: The present invention provides a process and an apparatus which will greatly reduce the amount of emitted ammonia and odour from in particular animal stables by a process which is both efficient, reliable and relatively inexpensive to carry out, and which at the same time removes ammonia to a concentration... Agent: Roberts, Mlotkowski & Hobbes

20080070291 - Compositions and methods for enzymatic decolorization of chlorophyll: The invention provides compositions and methods for the enzymatic treatment (“bleaching” or “de-colorizing”) of chlorophyll-comprising compositions, e.g., algae preparations, chlorophyll-containing or chlorophyll-contaminated feeds, foods or oils, for example, vegetable oils, including oils processed from oilseeds, such as canola (rapeseed) oil or soybean oil, or oil fruits, such as palm oil.... Agent: Verenium C/o Mofo S.d.

20080070292 - Sieve for bio-impactor, bio-impactor equipped with such a sieve: The invention concerns a sieve (2) for bio-impactor (1), characterized in that it comprises air passages (6) from upstream (M) towards downstream (V) of the sieve (2), the passages (6) having a gradually tapering cross-section from an inlet (11) towards an outlet (12). Preferably, the inlets (11) are mutually connected... Agent: Young & Thompson

20080070293 - Enzyme-based monitoring device for thermal processing of objects: This invention provides an enzyme-based monitoring device for monitoring the thermal impact of thermal processing on an object. The device comprises a sealed container enclosing a solid dehydrated mix comprising at least one enzyme and at least one first filler, sealing of the sealed container being obtained by means of... Agent: Clark & Elbing LLP

20080070294 - Mobile modular, multi-chamber composting system: A mobile, modular multi-chamber composting system for the composting of organic material includes a composting unit having a pair of adjacent composting chambers enclosed by sidewalls, a roof, and closure panels, with the chambers delimited by a separation panel, and the first chamber having a uni-directional tilting floor and the... Agent: The Inventors Network, Inc.

20080070295 - Flask for preparing a cytological suspension: A flask for preparing a fixer-based cytological suspension is equipped with a filtering element (4) at least partly immersed in the suspension. The filtering element is in the form of a basket-forming filtering material web, whereof the periphery (5) is fixed on the flask and whereof the center (6) is... Agent: Young & Thompson

20080070296 - Compositions for enhancing segregation of transgenes in plants: The compositions and methods are provided that enhance the selection of transgenic plants having two T-DNA molecules integrated into a plant genome at different physical and genetic loci. The compositions are DNA constructs that comprise novel arrangements of T-DNA molecules containing genes of interest, positive selectable marker genes, and conditional... Agent: Thompson Coburn, LLP

20080070297 - Regulatory elements for delivery to the liver: The invention is directed to novel combinations of liver specific enhancers and promoter elements for achieving persistent transgene expression in the liver. The liver specific enhancer elements may be derived from either the human serum albumin, prothrombin, α-1microglobulin or aldolase genes in single copies or in multimerized from linked to... Agent: Genzyme Corporation Legal Department

20080070298 - Promoter of synoviolin gene: The present invention provides a promoter of the synoviolin gene comprising at least the nucleotide sequence of nucleotides 2120-2130 in the nucleotide sequence represented by SEQ ID: NO 1 or 2, or comprising at least the nucleotide sequence of the region of nucleotides 1-2201, 969-2201, 1142-2201, 1699-2201, 1880-2201, 2002-2201, 2094-2201... Agent: Dickstein Shapiro LLP

20080070299 - Synthetic nucleic acid molecule compositions and methods of preparation: A method to prepare synthetic nucleic acid molecules having reduced inappropriate or unintended transcriptional characteristics when expressed in a particular host cell.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20080070300 - Human chemotactic cytokine: The invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to isolated and/or recombinant human eotaxin proteins or polypeptides, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin, a... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080070301 - Methods for preparing xenotransplantable porcine islets: The invention relates to a method of preparing a xenotransplantable porcine islet preparation capable upon xeno-transplantation of producing porcine insulin in an appropriate recipient mammal, the method including or comprising: (i) harvesting the pancreas of piglets at or near full term gestation, and (ii) extracting islets from a culture of... Agent: Haynes And Boone, LLP

20080070302 - Method for treatment of cellular materials with sugars prior to preservation: Living cellular material may be preserved by incubating the cellular material in a culture medium containing at least one sugar, particularly for at least three hours, and then subjecting the cellular material to a preservation protocol, such as freezing, vitrification, freeze-drying and desiccation.... Agent: Oliff & Berridge, PLC

20080070303 - Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby: This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation... Agent: Ropes & Gray LLP Patent Docketing 39/361

20080070304 - Self-assembling cell aggregates and methods of making engineered tissue using the same: A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into... Agent: Senniger Powers LLP

20080070305 - Inhibition of expression of a target gene: The present invention relates to a process to inhibit the expression of a target gene in cells or tissues by infecting said cells or tissues with viral particles.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20080070306 - Regulated gene expression in plants: A method is provided of regulating transcription in a plant cell from a DNA sequence comprising a target DNA operably linked to a coding sequence, which method comprises introducing an engineered zinc finger polypeptide in said plant cell which polypeptide binds to the target DNA and modulates transcription of the... Agent: Robins & Pasternak

20080064022 - Dynamic fermentation controller: One or more set point values are generated by a dynamic fermentation controller for one or more of temperature, pH, and enzyme dosage for a fermentation system. The one or more set point values are output to one or more controllers of the fermentation system. The generation of the one... Agent: Sadler, Breen, Morasch & Colby, P.s.

20080064023 - Oligomer probe array with improved signal-to-noise ratio fabrication method thereof: An oligomer probe array with improved signal-to-noise ratio includes a substrate, a plurality of probe cell active regions formed on or in the substrate, with each of the plurality of probe cell active regions having a substantially planar surface and being coupled with at least one oligomer probe with own... Agent: Frank Chau, Esq. F. Chau & Associates, LLC

20080064025 - Cooperative reporter systems, components, and methods for analyte detection: The present invention relates to methods and compositions to detect analytes in a sample using antibody molecules that are transformed into nanoscale “self-signaling” biosensors. It relates in particular to those methods and compositions that provide for single-step detection of target analytes without the need for labor-intensive steps necessary in conventional... Agent: Sonnenschein Nath & Rosenthal LLP

20080064030 - Cpg-amplicon and array protocol: The invention can be summarized as follows. There is provided a method for amplifying hypomethylated genomic nucleotide sequences and/or hypermethylated genomic nucleotide sequences and comparing the methylation state between different samples, for example control and test samples. Also disclosed is a microarray based method for analysing hypo and/or hypermethylated genomic... Agent: Suzannah K. Sundby Smith, Gambrell & Russel, LLP

20080064029 - Methods and nucleic acids for analyses of colorectal cell proliferative disorders: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved... Agent: Davis Wright Tremaine, LLP/seattle

20080064032 - Polynucleotides and uses thereof: A novel transgenic wheat event designated JOPLIN1, is disclosed. The invention relates to DNA sequences of the recombinant constructs inserted into the wheat genome and of genomic sequences flanking the insertion site that resulted in the JOPLIN1 event. The invention further relates to assays for detecting the presence of the... Agent: Syngenta Biotechnology, Inc. Patent Department

20080064028 - Quantitative pcr method of detecting specific plant genus in food or food ingredient: Provided is a method of quantifying a specific plant genus in a food or a food ingredient by a PCR method, comprising: (i) preparing a sample for correction where a sample derived from the specific plant genus to be detected and a standard plant sample are mixed in a predetermined... Agent: Birch Stewart Kolasch & Birch

20080064027 - Tel/etv6-mediated inhibition of cell proliferation: A method of modulating Stat3-dependent and cytokine-sensitive cell proliferation is provided, as well as screening methods for agents affecting Stat3-dependent and cytokine-sensitive cell proliferation. The method is exemplified by modulating TEL/ETV 6.... Agent: Novartis Corporate Intellectual Property

20080064045 - Biomarker fragments for the detection of human bnp: The present invention relates among other things to a composition comprising at least two (2) human BNP fragments, wherein each of the human BNP fragments of the composition are cross-linked to at least one of the other human BNP fragments of the composition.... Agent: Robert Deberardine Abbott Laboratories

20080064050 - Applications of the binding interaction of proanthocyanidins with bacteria and bacterial components: A composition having: a proanthocyanidin; and a macromolecule, an assembly of macromolecules, a semi-solid, or a solid surface to which the proanthocyanidini is immobilized.... Agent: Naval Research Laboratory Associate Counsel (patents)

20080064051 - Method of diagnosing tuberculosis: The present invention relates to a method of diagnosing tuberculosis in a subject, said method comprising steps of: detecting anti-Mycobacterium tuberculosis (M.tb.) isocitrate dehydrogenase (ICDs) antibody in the subject, and diagnosing tuberculosis in the subject.... Agent: Vern Maine & Associates

20080064053 - Genotoxicity testing: A recombinant vector comprises a recombinant DNA molecule comprising a DNA sequence that encodes a light emitting reporter protein. The DNA sequence is operatively linked to a regulatory element arranged to activate expression of the DNA sequence in response to DNA damage. When used to transform a cell, the vector... Agent: Hogan & Hartson L.L.P.

20080064057 - Vaccine protection assay: The present invention relates to the field of Serum Bactericidal Activity (SBA) assays for Gram negative bacteria, in particular N. meningitidis. The SBA assay is the most important method for measuring functional activity of serum antibodies against meningococcus. In order to determine whether a subject or a population is seropositive... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20080064021 - Direct application of non-toxic crosslinking reagents to resist progressive spinal degeneration and deformity: A method of treatment of native, non-denatured tissue to increase resistance to tearing, fissuring, rupturing, and/or delamination, comprising the step of: contacting at least a portion of the tissue with an effective amount of a reagent that increases crosslinks in the tissue.... Agent: Robert Berliner Berliner & Associates

20080064024 - Methods and apparatus for enzyme inhibitors analysis: Methods and Apparatus for Enzyme Inhibitors Analysis The present invention provides apparatus and methods for determining an amount of an enzyme inhibitor in an aqueous solution, wherein an electrode strip and an electroanalysis meter are utilized, and the electrode strip can only be used one time. The present invention can... Agent: Reed Smith LLP

20080064026 - Compositions and methods for detecting and treating hiv infections: HIV infection can be detected by measuring phosphorylation levels of the actin-depolymerizing factor (AFD)/cofilin family, and infection can be treated and/or prevented by modulating the HIV co-receptor signaling pathway.... Agent: Foley And Lardner LLP Suite 500

20080064038 - Autism genes and regulated secretion: The present invention relates to genes encoding proteins involved in regulated secretion which are linked with the occurrence of or the susceptibility to a neural system disorder. The invention thus also relates to methods of identifying patients which have been diagnosed with a neural system disorder as susceptible to the... Agent: Clark & Elbing LLP

20080064041 - Biomap analysis: The involvement of an expression product in a cell in a pathway is determined by genetically modifying the cell, incubating the cell with predetermined factors in induce a physiological state and measuring parameters affected by the pathway. Changes in the levels of the parameters as a result of the presence... Agent: Bozicevic, Field & Francis LLP

20080064042 - Compositions for detection and analysis of polynucleotides using light harvesting multichromophores: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor polynucleotide complementary to the target polynucleotide. The sensor polynucleotide comprises a signaling chromophore to receive energy from... Agent: Bio Technology Law Group C/o Portfolioip

20080064039 - Dominant negative ligand drug discovery system: The present invention relates to novel methods of designing and optimizing polypeptide based ligands which are useful for altering and/or modulating cellular signaling cascades which have become dysregulated. The therapeutic dominant negative ligands (DNLs) and DNL variants designed by the methods herein have useful applications in medicine, diagnostics and drug... Agent: Elmore Patent Law Group, PC

20080064043 - Method for detecting a methylation pattern: The present invention relates to a method for detecting the presence of one or more methylation patterns. It comprises the conversion of nucleic acids and a catalytic nucleic acid activity. Here, the conversion of the nucleic acid is characterized such that the 5-methylcytosine remains unchanged while the unmethylated cytosine is... Agent: Kriegsman & Kriegsman

20080064035 - Method for determining biophysical properties: The invention is a method for detecting a change in the conformational or energetic state of a molecular species, comprising the steps of: (i) immobilizing the molecular species, under conditions suitable for the reaction to occur; (ii) contacting at least part of the molecular species with a localized electromagnetic field;... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080064033 - Molecular beacons: The invention relates to a molecular beacon in the form of a hairpin oligonucleotide or oligonucleotide analogue comprising a first nucleotide sequence containing two or more aromatic or heteroaromatic ring systems P able to form an excimer or exciplex; a second sequence (the loop) consisting of an oligonucleotide probe able... Agent: Joyce Von Natzmer Pequignot + Myers LLC

20080064040 - Monitoring gene silencing and annotating gene function in living cells: The cell-based assays described in the present invention can be used to directly assess the sensitivity and specificity of the gene annotation reagent against its target, and to determine if a non-targeted gene participates in a pathway of interest or is functionally linked to another gene or protein. The combination... Agent: Isaac A. Angres

20080064034 - Multi-cellular test systems: The invention relates to methods for testing substances using multicellular in vitro test systems, in particular systems that resemble organs, and to devices and kits for carrying out said methods.... Agent: Pearl Cohen Zedek Latzer, LLP

20080064036 - P75ntr screening assay: The present invention provides a method to identify a test compounds capability to modulate p75NTR induced apoptosis, said method comprising: i. Transfecting a suspension of eukaryotic cells with a vector encoding p75NTR (SEQ ID No.2) or a cell death inducing fragment thereof, ii. Contacting said cells with the compound to... Agent: Philip S. Johnson Johnson & Johnson

20080064031 - Processes for purifying and for detecting target double-stranded dna sequences by triple helix interaction: The present invention relates to novel target double-stranded DNA sequences capable of interacting with a third strand and of forming a stable triple helix. The present invention also relates to a process for purifying a double-stranded DNA molecule, according to which a solution containing said DNA molecule is brought into... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080064037 - Rna-selective probes for live cell imaging of nuclear structure and function: The present invention is directed to fluorescent compounds and methods of making said compounds that selectively bind to cellular RNA. The fluorescent compounds of the present invention are useful for live cell imaging applications.... Agent: Nixon Peabody LLP - Patent Group

20080064044 - Analysis of insulin-like growth factors from biological fluids by the use of affinity-based mass spectrometric methods: Presented herein are affinity-based mass spectrometric methods and assays for analysis of insulin like growth factors 1 and 2 (IGF-1 and IGF-2) present in complex biological mixtures and fluids. IGF-1 and IGF-2 were assayed from human plasma via BIA/MS, utilizing antibodies as ligands for affinity retrieval. Detection of both targeted... Agent: Snell & Wilmer L.L.P. (main)

20080064046 - Assays: The present invention is directed to assays that can be used to screen for compounds that act as agonists or antagonists or inverse agonists of bovine adrenal medulla docosapeptide (BAM-22P). The assays are based upon the binding of BAM-22P to the rat and human DRR receptors.... Agent: Astra Zeneca Pharmaceuticals Lp Global Intellectual Property

20080064048 - Methods for selecting proteins that are readily presented as antigens on dendritic cells: The present inventors worked on elucidating the mechanism of antigen cross-presentation by dendritic cells, and revealed that foreign antigens taken up in dendritic cells are degraded by proteasomes after undergoing polyubiquitination. They discovered a positive correlation between the uptake amount of an antigenic protein by dendritic cells or the level... Agent: Foley & Lardner LLP

20080064049 - Compositions and methods for treating and diagnosing cancer: The present invention relates to compositions and methods for characterizing, treating and diagnosing cancer. In particular, the present invention provides a cancer stem cell profile, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of cancer and in particular the targeting of solid... Agent: Casimir Jones, S.c.

20080064047 - Methods for diagnosis and prognosis of epithelial cancers: The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to... Agent: Goodwin Procter LLP Patent Administrator

20080064052 - Crystal of a receptor-ligand complex and methods of use: The invention relates to the three-dimensional structure of a crystal of an EphB4 receptor complexed with a ligand. The three-dimensional structure of a Receptor-Ligand Complex is disclosed. The receptor-ligand crystal structure, wherein the ligand is an inhibitor molecule, is useful for providing structural information that may be integrated into drug... Agent: Biotactica, LLC

20080064054 - Fluorescence resonance energy transfer (fret) assays for clostridial toxin activity: Clostridial toxin substrates comprising a fluorescent donor, an acceptor, a Clostridial toxin recognition sequence including a cleavage site and a membrane targeting domain; methods for determining the activity of a Clostridial toxin from a test sample using such Clostridial toxin substrates; cell compositions comprising such Clostridial toxin substrates and a... Agent: Allergan, Inc.

20080064056 - Function homology screening: A method of screening biologically active agent based on the analysis of complex biological responses in culture. Methods for selecting cells and culture conditions for such screens are provided, as well as the identification of an optimized set of discrete parameters to be measured, and the use of biomap analysis... Agent: Bozicevic, Field & Francis LLP

20080064055 - Methods for the identification, assessment, and treatment of patients with cancer therapy: The present invention is directed to the identification of predictive markers that can be used to determine whether patients with cancer are expected to demonstrate long term or short term survival times. In particular, the present invention is directed to the use of certain individual and/or combinations of predictive markers,... Agent: Millennium Pharmaceuticals, Inc.

20080064058 - Method and system for detection of trichinella larvae in meat samples: The present invention relates to a method and a system for detection of Trichinella larvae in meat samples. The method comprises digestion of an amount of meat to be tested for Trichinella larvae, where the digestion process results in a digested fluid, filtering the digested fluid by use of a... Agent: Seed Intellectual Property Law Group PLLC

20080064059 - In vivo site-specific incorporation of n-acetyl-galactosamine amino acids in eubacteria: Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.... Agent: Quine Intellectual Property Law Group, P.C.

20080064063 - Compositions and methods for producing steviol and steviol glycosides: The present invention relates to nucleotide sequences encoding ent-kaurenoic acid 13-hydroxylase polypeptides and polypeptides having ent-kaurenic acid 13-hydroxylase activity. The invention also relates to methods of producing steviol and steviol glycosides.... Agent: Schwegman, Lundberg & Woessner, P.A.

20080064064 - Mannanases: The present invention provides an insertion, deletion and/or substitution mutein of wild-type Trichoderma reesei β-mannanase having enhanced thermostability, proteolytic stability, specific activity and/or stability at low pH, a nucleic acid molecule encoding said mannanase mutein, a composition comprising said mannanase mutein; a method for its preparation, and its use for... Agent: Rankin, Hill & Clark LLP

20080064060 - Method for productoin of soluble mhc proteins: The invention relates to a recombinant, purified MHC protein, which essentially comprises the same conformation functional activity and binding characteristics for specific antibodies and antigens as the native MHC protein. The invention also relates to a method for producing the protein. To obtain a protein, whose characteristics resemble those of... Agent: William Collard Collard & Roe, P.C.

20080064062 - Microorganism strain for producing recombinant proteins: A microorganism strain comprises a gene coding for a recombinant protein and a mutated gene coding for a host protein that is not a protease. The recombinant protein is secreted during a fermentation and the mutated gene coding for the host protein has been mutated so as to cause reduced... Agent: Brooks Kushman P.C.

20080064065 - Non-activated polypeptides having a function of tissue regeneration and method for preparing the same: Non-activated tissue-regeneration polypeptides (TRPs) and their preparation methods are disclosed. The TRPs include: a protein transduction domain (PTD) making the polypeptides to permeate a cell membrane without cell membrane receptors; a furin activation domain (FAD) which has at least one proprotein convertase cleavage site and which can be cleaved by... Agent: Intellectual Property / Technology Law

20080064061 - Yeast promoter: The present invention provides a DNA fragment exhibiting a potent promoter activity when used in the yeast. The present invention relates to a DNA fragment possessing a transcription promoter activity of the yeast, said DNA fragment having a whole of the DNA sequence shown by SEQ ID NO: 1 or... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080064066 - Modified human granulocyte-colony stimulating factor and process for producing same: A modified human granulocyte-colony stimulating factor (hG-CSF) is produced by culturing a microorganism transformed with an expression vector comprising a gene encoding a modified hG-CSF to produce and secrete the modified hG-CSF to periplasm, said modified hG-CSF being obtained by replacing at least one of the 1st, 2nd, 3rd and... Agent: Anderson, Kill & Olick, P.C.

20080064067 - Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20080064068 - Method of production of recombinant proteins in eukaryote cells: The invention provides a method for production of polypeptides in eukaryote microcarrier cell culture, the method comprising the steps of (i) Culturing cells expressing said polypeptide on microcarriers under conditions and at a setpoint temperature appropriate for expression of said polypeptide; (ii) Cooling the culture to a predetermined temperature below... Agent: Novo Nordisk, Inc. Patent Department

20080064069 - Method for producing udp-rhamnose and enzyme used for the method: A protein having (a) an amino acid sequence represented by SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 20, SEQ ID NO: 6 or SEQ ID NO: 8, or (b) an amino acid sequence represented by SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO:... Agent: Birch Stewart Kolasch & Birch

20080064070 - Polynucleotide synthesis on a modified surface: The present invention relates to a method for the synthesis of a polynucleotide on a modified surface of a substrate, wherein the modified surface is obtained by chemically modifying with macromolecules in which a plurality of termini of the branched region are bound to the surface and a terminus of... Agent: Jhk Law

20080064071 - Zwitterionic detergents for the storage and use of dna polymerases: The present invention provides methods, compositions, and kits for storing and enhancing the activity of thermostable polymerases. The methods comprise mixing a thermostable polymerase with at least one zwitterionic detergent or non-detergent surfactant. Compositions and kits for performing the process according to the invention are also provided.... Agent: Agilent Techologies Inc

20080064072 - Process for producing poly(vinyl alcohol)-bacterial cellulose nanocomposite: Hydrogel-bacterial cellulose nano-composite materials are created using a hydrogel and never dried bacterial cellulose fibers. Such materials are suitable for a broad range of soft tissue replacement applications. In addition controlled release of bioactive agents properties can be designed into medical devices fabricated from such composite materials.... Agent: Ralph A. Dowell Of Dowell & Dowell P.C.

20080064073 - Process for preparing: A process for obtaining a xantan-like biopolymer from bacterial strains from Xanthomonas arboricola and/or Xanthomonas arboricola pv pruni colonies added to fermentation media containing residual waters and products related to the processing of hull-containing rice and parboilized rice and other nutrients is described, the process starting from an initial pre-inoculum... Agent: Mcglew & Tuttle, PC

20080064074 - Process for producing coenzyme q10: The invention aims at providing a process for producing coenzyme Q10 efficiently in microorganisms by utilizing a coenzyme Q10 side chain synthesis gene derived from a fungal species belonging to the genus Rhodotorula. The present invention relates to a DNA having a DNA sequence described under SEQ ID NO:1, 3... Agent: Kenyon & Kenyon LLP

20080064076 - Dissolved oxygen profile to increase fermentation productivity and economics: Aerobic fermentation processes and systems establish, via sensing and regulating, a particular dissolved oxygen (DO) profile throughout fermentation to improve the fermentation processes. For some embodiments, the DO profile may follow one cycle of increasing and decreasing DO level in a fermentation media from lag to stationary phases of microorganisms... Agent: Air Liquide Intellectual Property Dept.

20080064075 - Method of treating waste from alcohol production: A method of treating a plurality of byproducts generated in the process of producing alcohol using corn as a raw material, and making effective use of them, particularly as feed compositions. The method of treating byproducts generated in the process of producing alcohol from corn comprises a step of using... Agent: Pearne & Gordon LLP

20080064077 - Method and apparatus for cutting and collecting dissected specimens: Methods and devices for cutting and collecting dissected specimens are described herein. In one embodiment, the method for dissecting and collecting specimens includes the following steps: placing a sample onto a slide of a laser dissection microscope, the slide being translatable in its plane of extension, lowering an adherent collection... Agent: Patrea L. Pabst Pabst Patent Group LLP

20080064078 - Rotary motor molecule v1-atpase: A complex rotating in the presence of ATP, which has three A subunits, three B subunits and one D subunit constituting the V1 portion of a V0V1,-ATPase.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080064079 - C-terminal modification of polypeptides: The invention relates to a mutated trypsin comprising an amino acid substitution both at position K60 and D189, and at least one more amino acid substitution by histidine at position N143 or position E151. Such trypsin mutant has a preferred cleavage site comprising the amino acids Xaa1-Xaa2-His, wherein Xaa1 is... Agent: Roche Diagnostics Operations Inc.

20080064080 - Animal protein-free media for cultivation of cells: The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating... Agent: Baxter Healthcare Corporation

20080064081 - Structural protein of adeno-associated virus with modified antigenicity, its production and its use: The present invention relates to a structural protein of adeno-associated virus (AAV) which comprises at least one modification which brings about a reduction in the antigenicity, its production and use.... Agent: Clark & Elbing LLP

20080064082 - Control of function of intracellular ca ion: Analysis of substance capable of binding with inositol-1,4,5-triphosphate (IP3) receptor (IP3R), preferably with a regulation domain of IP3R; analysis of the function of IP3R; and establishing of a method of treatment or diagnosis for various malfunctions and diseases associated with IP3R. In particular, control of the activity of intracellular Ca2+... Agent: Edwards Angell Palmer & Dodge LLP

20080064083 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080064084 - Method for producing recombinant trypsin: The present invention concerns a method for producing recombinant trypsin from porcine pancreas in Pichia pastoris which is soluble and secreted into the culture medium, whereby expression at pH 3.0-4.0 substantially prevents activation of trypsinogen to β-trypsin and autolysis of β-trypsin by α-trypsin into ε-trypsin and from there into inactive... Agent: Barnes & Thornburg LLP (roche)

20080064085 - Microwave-assisted heating and processing techniques: Apparatus are provided which include a specimen vessel holding at least one biological sample. A histological agent is in the specimen vessel so as to come into contact with the tissue sample. A microwave susceptor is provided in, near, or integral to the specimen vessel.... Agent: Miele Law Group, PC

20080064086 - Plastic-based microfabricated thermal device, manufacturing method thereof, dna amplification chip using the plastic-based microfabricated thermal device, and method for manufacturing the dna amplification chip: Provided are a microfabricated thermal device using a thin plastic substrate, a manufacturing method thereof, a silicon micro-chamber, a double-stranded deoxyribonucleic acid (DNA) amplification chip employing the microfabricated thermal device and the silicon micro-chamber, and a manufacturing method thereof, and a DNA amplification chip array, and a method for manufacturing... Agent: Rabin & Berdo, PC

20080064087 - Systems and methods for generating compost: Systems and methods for the generation of compost are provided. In one embodiment, the system for generating compost comprises a positively aerated floor, a semi gas and liquid impermeable compost cover sized to cover a compost biomass pile placed on the positively aerated floor, and a suction system positioned under... Agent: Speckman Law Group PLLC

20080064088 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati

20080064089 - Biological growth plate scanner with automated image processing profile selection: A biological scanner provides automated selection of image processing profiles to scan different types of biological growth plates. The scanner automatically identifies the type of plate to be scanned by the scanner, and then selects one of the image processing profiles appropriate for the identified plate type. For example, the... Agent: 3m Innovative Properties Company

20080064090 - Culture dish with lid: A device for culturing cells or tissue includes a culture dish with a bottom wall and at least one sidewall to define an interior cavity, at least one channel formed on the bottom wall to minimize the effect of fluid movement on biologics in the dish and, optionally, at least... Agent: Wood, Herron & Evans, LLP

20080064091 - Cassette for nucleic acid expression in plants: The invention provides genetic constructs containing a promoter of the AtMYB60 gene for the selective expression of nucleic acid sequences in plant stomatal guard cells, vectors and host plants containing them.... Agent: Young & Thompson

20080064092 - Fusion proteins: The invention provides a single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a target cell; a Targeting Moiety that is capable of binding to a Binding Site on... Agent: Merchant & Gould PC

20080064093 - Compositions and methods employing zwitterionic detergent combinations: The present invention provides lysis reagents, containers, methods and kits relating to the extraction or the extraction and isolation of a cellular component from a host cell. More specifically, the invention provides combinations of zwitterionic compounds that may be employed to aide in the extraction or the extraction and isolation... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080064095 - Method for obtaining mastocyte lines from pig tissues and for producing heparin-type modules: The present application relates to a method for obtaining mastocyte cultures or lines. It also relates to a method for producing heparin-type molecules, comprising the culturing of mastocyte cultures or lines.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080064094 - Polynucleotides encoding two novel human g-protein coupled receptors, hgprbmy28 and hgprbmy29, and splice variants thereof: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors,... Agent: Louis J. Wille Bristol-myers Squibb Company

20080064096 - Isolated nucleic acid molecules which encode a soluble il-tif receptor or binding protein which binds to il-tif/il-22, and uses thereof: The invention relates to soluble proteins which bind to the molecule known as IL-TIF/IL-22. The proteins can antagonize the effect of IL-TIF/IL-22 on target cells. The nucleic acid molecules encoding the proteins, and uses of the protein, are also described.... Agent: Wyeth/finnegan Henderson, LLP

20080064097 - Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof: The present invention relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the leafhopper ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods for modulating gene expression in an ecdysone receptor-based gene expression modulation... Agent: Sughrue Mion, PLLC

20080064099 - Isolation of inner cell mass for the establishment of human embryonic stem cell (hesc) lines: A method of establishing a cell line from the inner cell mass of a blastocyst, comprising: isolating a blastocyst having a zona pellucida, a trophectoderm, and an inner cell mass; creating an aperture in the blastocyst by laser ablation; isolating cells from the inner cell mass from the blastocyst through... Agent: Vinson & Elkins, L.L.P.

20080064098 - Procurement, isolation and cryopreservation of maternal placental cells: Methods, processes and systems for procuring, isolating and cryopreserving at least one viable, multipotent maternal placental stem cell is provided. Viable maternal placental stem cells are also provided. The maternal placental stem cell of the invention expresses the cell surface marker CD117 and at least one of the cell surface... Agent: John W. Goldschmidt, Jr. Esquire Dilworth Paxon LLP

20080064101 - Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices: The invention relates to a method for lymphoid tissue-specific cell production from hematopoietic progenitor cells in unique, three-dimensional culture devices, in the presence of antigen presenting cells and lymphoreticular stromal cells, and in the absence of exogenously added growth factors. The resulting lymphoid tissue-specific cells may be isolated at any... Agent: Wolf Greenfield & Sacks, P.C.

20080064100 - Method for preparation of an autologous endometrial culture for an endometrium-embryo coculture: The invention relates to a method for the preparation, from an endometrial biopsy, of an autologous endometrial coculture system. The aforementioned method comprises steps yielding a first endometrial fraction referred to as the epithelial fraction, a second endometrial fraction referred to as the stromal fraction and a third endometrial fraction... Agent: Mcleland Patent Law Office, P.l.l.c.

20080064104 - Antagonists and agonists of ldcam and methods of use: The invention pertains to agonists and antagonists of LDCAM and methods of treating disease and infection by administering one or more LDCAM antagonists or agonists. This abstract is provided for the sole purpose of enabling the reader to quickly ascertain the subject matter of the technical disclosure and is not... Agent: Amgen Inc. Law Department

20080064103 - Product and method for treatment of conditions associated with receptor-desensitization: Particular members of the multisubunit immune recognition receptor (MIRR) family of receptors, specifically, the B cell antigen receptor (BCR), the pre-B cell receptor (pre-BCR), the pro-B cell receptor (pro-BCR), Ig Fc receptors (FcR), and NK receptors, can be physically uncoupled from their associated transducers. The invention describes regulatory compounds and... Agent: Sheridan Ross PC

20080064102 - Transiently immortalized cells for use in gene therapy: The invention provides methods and compositions for expanding cells that are not abundant or are difficult to obtain in pure form in culture, are in short supply (e.g., human cells), or have brief lifetimes in culture, using fusion polypeptide. The fusion polypeptide has a first region having the transport function... Agent: Knobbe Martens Olson & Bear LLP

20080064105 - Animal protein-free media for cultivation of cells: The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating... Agent: Baxter Healthcare Corporation

20080064106 - Lentiviral ltr-deleted vector: A vector capable of transducing non-dividing and/or slowly dividing cells is provided, wherein the vector is a lentiviral LTR-deleted vector. Also provided is a method for producing a protein of interest in a non-dividing or slowly dividing cell by transducing the cell with a lentiviral LTR-deleted vector and expressing the... Agent: Frommer Lawrence & Haug

20080064107 - Use of multiple transformation enhancer sequences to improve plant transformation efficiency: The present invention relates to methods and compositions for improving the efficiency of Agrobacterium- and Rhizobium-mediated plant cell transformation by use of additional transformation enhancer sequences, such as overdrive or TSS sequences, operably linked to a T-DNA border sequence on a recombinant construct that comprises T-DNA.... Agent: Sonnenschein Nath & Rosenthal LLP

20080057486 - Tissue preservation solution: An object of the invention is to provide a tissue preservation solution that has excellent tissue-preserving ability and is useful in the field of medicine, medical experiment, etc. Thus, the invention relates to a tissue preservation solution including oxygen nanobubbles.... Agent: Arthur G. Schaier Carmody & Torrance LLP

20080057489 - Photolabile compound and substrate for oligomer probe array with the same: Provided is a substrate for an oligomer probe array to which a photolabile material having an acetylene derivative is directly attached or attached via a linker.... Agent: Frank Chau, Esq. F. Chau & Associates, LLC

20080057492 - Interacting site for gp41 on gp120 of hiv-1: Mutations in the amino and carboxy terminal halves of HIV-1 gp120 and the carboxy terminus of gp41 are disclosed which contribute to the neutralization resistance and high infectivity phenotypes of HIV-1.... Agent: Morgan Lewis & Bockius LLP

20080057497 - Bioluminescence resonance energy transfer report element for biological arrays: t

20080057495 - Marchantiales-derived unsaturated fatty acid synthetase genes and use of the same: A Δ5 fatty acid desaturase gene, a Δ6 fatty acid desaturase gene, and a Δ6 fatty-acid-chain elongase gene are isolated from a single species of Marchantiales. By introducing these genes into higher plants, transformed plants which can produce arachidonic acid and eicosapentaenoic acid (EPA) are obtained.... Agent: Drinker Biddle & Reath (dc)

20080057513 - Method for producing nucleic acid probes: The present disclosure provides nucleic acid probes, as well as kits that include such probes. Methods for producing and using (for example in chromosomal in situ hybridization) the probes are also provided. Such probes in some examples are used to detect chromosomal abnormalities or the presence of a pathogen.... Agent: Klarquist Sparkman, LLP

20080057496 - Methods of identifying point mutations in a genome that affect the risk for or the age of appearance of disease: The invention relates to a method for identifying inherited point mutations in a targeted region of the genome in a large population of individuals and determining which inherited point mutations are deleterious, harmful or beneficial. Deleterious mutations are identified directly by a method of recognition using the set of point... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080057511 - Phenotypic screen for plants: The present invention is directed to a method of identifying plants with enhanced agronomic traits within a larger population of plants grown from a randomly planted set of seeds.... Agent: Monsanto Company

20080057494 - Ribosomal rna methyltransferases rima:target validation and processes for deleloping an inhibitor assay and identification of candidate inhibitors: The invention provides a target and methods for specific binding and inhibition of RlmA proteins from bacterial specie The invention is directed to a method for identifying compounds that bind to a bacterial RlmA-binding pocket, comprising preparing a reaction solution comprising the compound to tested and an entity comprising a... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20080057515 - Beta-like glycoprotein hormone polypeptide and heterodimer: Novel β10 polypeptides and heterodimers thereof, and nucleic acid molecules encoding the same are disclosed. The invention also provides vectors, host cells, selective binding agents, and methods for producing β10 polypeptides and heterodimeric forms thereof, specifically α2/β10. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of... Agent: Amgen Inc.

20080057516 - Novel receptor for gdnf family ligands: The present invention relates to an in vitro method for identifying a molecule, which interferes with the interaction between a glial cell-line derived neurotrophic factor family ligand (GFL) and a heparan sulfate proteoglycan (HSPG), by screening a library of molecules against a matrix anchored complex comprising at least one immobilized... Agent: Arent Fox LLP

20080057519 - Cell surface protein associated with human chronic lymphocytic leukemia: Protein (referred to herein as “FLJ32028”) that is associated with B-cell chronic lymphocytic leukemia is isolated. Isolated nucleic acid encoding the protein, the generation of monoclonal antibodies recognizing at least a portion of this protein, and the use of this protein or antibodies thereto as a diagnostic marker or therapeutic... Agent: Ropes & Gray LLP Patent Docketing 39/361

20080057522 - Method for screening agents modulating ikbalpha protein ubiquitination and means for carrying out said method: o

20080057525 -