Chemistry: molecular biology and microbiology inventions 02/08

20080050718 - Methods, articles, and compositions for identifying oligonucleotides: There are many situations where oligonucleotides that efficiently bind a target DNA or RNA are desired. These oligonucleotides can be used for a variety of purposes, including antisense, diagnostics, and array generation. While researchers have worked for many years to identify algorithms and methods for predicting the oligonucleotides that will... Agent: Needle & Rosenberg, P.C.

20080050729 - Complex cancer cells luminescence detection method: A method for detecting cancer cells. A chemical luminescence reaction is used to obtain a result image. The result image is analyzed through a weighting process to a value of each gene. By doing do, a cancer can be precisely diagnosed.... Agent: Troxell Law Office PLLC

20080050721 - Detection and quantitation of nucleic acid molecules in biological samples: The present invention concerns processes for the detection and quantitation of nucleic acid molecules, polynucleotides, and/or oligonucleotides in a sample using hybridizationdetection assays, antibody-mediated recognition assays, nucleic acid sensor molecules, chromatographic assays, and/or electrophoresis assays. The present invention specifically concerns processes for the detection and quantitation of double stranded nucleic... Agent: Mcdonnell, Boehnen, Hulbert And Berghoff, LLP

20080050719 - Gene expression profiles in liver disease: The present invention results from the examination of tissue from hepatic carcinomas to identify genes differentially expressed between cancerous liver tissue and diseased but non-cancerous liver tissue. The invention includes diagnostic, screening, drug design and therapeutic methods using these genes, as well as solid supports comprising oligonucleotide arrays that are... Agent: Morgan Lewis & Bockius LLP

20080050724 - Method of detecting one or more limited copy targets: A method allowing simultaneous amplification of multiple low-abundance targets in environmental samples. This is a two-step process that includes a combined reverse transcription and pre-amplification step, which utilizes a mix of gene-specific primer sets, followed by a second amplification step performed on the previously generated “RT-amplification” product. Initial amplification of... Agent: Haverstock & Owens LLP

20080050726 - Methods for diagnosing pancreatic cancer: The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into an algorithm where the algorithm normalizes the Biomarkers against a reference; and... Agent: Philip S. Johnson Johnson & Johnson

20080050720 - Methods for using a sterol biosynthesis pathway reporter gene to screen for antifungal or lipid lowering compounds: The present invention relates to methods of using nucleotide sequences from the promoter region of a S. cerevisiae gene YRM325W whose expression is an indicator of inhibition or modulation of the sterol biosynthesis pathway in S. cerevisiae. The invention envisions using a target polynucleotide sequence, wherein the target polynucleotide sequence... Agent: Rosetta Inpharmatics, Inc.

20080050725 - Methods of detecting dna n-glycosylases, methods of determining n-glycosylase activity, and n-glycosylase assay kits: The invention includes methods of detecting glycosylases. A test sample is mixed with substrate polynucleotide. A primer and a polymerase are added. An endonuclease is provided and a probe oligonucleotide sequence labeled with first and second labels is utilized for detection. The invention includes N-glycosylase assay methods. A test sample... Agent: Battelle Energy Alliance, LLC

20080050723 - Molecular method for diagnosis of colon cancer: Methods for diagnosing or detecting cancerous colon tissue. A panel of 21 specific marker genes are provided. The overexpression of some of these marker genes compared to their expression in normal colon tissue and the underexpression of the rest of these marker genes are indicative of cancerous colon tissue. By... Agent: Shapiro Cohen

20080050722 - Novel mirna molecules isolated from human embryonic stem cell: The present invention relates to novel miRNA molecules, more particularly to novel miRNA molecules isolated from human embryonic stem cells. The miRNA molecules provided by the present invention can be usefully used as a molecular marker for early developmental stages of undifferentiated human embryonic stem cells. Also, the miRNA molecules... Agent: Buchanan, Ingersoll & Rooney PC

20080050749 - Use of bnp-type peptides for the stratification of therapy with erythropoietic stimulating agents: The present invention relates to the diagnosis of the risk of experiencing a cardiovascular complication in the context of treatment with erythropoiesis stimulating agents (ESA's) such as erythropoietin and derivatives thereof particularly in the context of anemia. More particularly, the invention provides a method for diagnosing the risk of a... Agent: Roche Diagnostics Operations Inc.

20080050757 - Rapid method for detecting mutated genes: The present invention is a rapid, specific, and sensitive method of detecting mutations in receptor tyrosine kinase genes in formalin fixed tissue embedded in paraffin blocks to detect mutations.... Agent: Bell, Boyd & Lloyd, LLP

20080050759 - Screening assay for anti-bacterial compounds: The invention relates to methods of screening for compounds having anti-microbial efficacy. More specifically the invention relates to transcription/translation assays for the identification of compounds that exhibit inhibitory effects on bacterial growth.... Agent: Jeffrey M. Greenman

20080050761 - Sox-based kinase sensor: Peptidyl sensors comprise a metal-binding peptide and one or two kinase recognition sequences with a hydroxyamino acid that can be phosphorylated in the presence of a kinase.... Agent: Brinks Hofer Gilson & Lione

20080050764 - Method and apparatus for measuring enviromental allergen: A method for measuring an environmental allergen by which the allergen may be measured simply without using an anti-allergen antibody, as well as an instrument and apparatus therefor, is disclosed. In the method for measuring the environmental biological allergen, the biological allergen is measured by measuring the protease activity of... Agent: Birch Stewart Kolasch & Birch

20080050770 - Method for the production and purification of adenoviral vectors: The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have... Agent: Fulbright & Jaworski L.L.P.

20080050774 - Bacillus licheniformis chromosome: The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substances and to nucleic acid constructs, vectors, and host cells comprising the genes as well as methods... Agent: Novozymes, Inc.

20080050778 - Recombinant methods for expressing a functional umami (t1r1/t1r3) taste receptor: e

20080050716 - Methods for preserving organs and tissues: The invention relates to a method for preserving an organ or tissue comprising contacting the organ or tissue with an effective amount of a kallikrein inhibitor and solutions useful for such a method. Also provided is a method for reducing reperfusion injury of an organ during surgery and/or following removal... Agent: Fish & Richardson PC

20080050717 - Cryopreservation and recovery system for liquid substances: The present invention provides a method of preserving human red blood cells including the acts of cryogenically freezing a number of human red blood cells suspended in a fluid at a rate of 20° C. to 100° C. per second, maintaining a predetermined thickness of the fluid between a pair... Agent: Michael Best & Friedrich LLP

20080050737 - Ambient temperature stable kits for molecular diagnostics: A method for processing DNA polymerase and/or dNTPs for use in an amplification procedure, includes providing a solution mixture, the solution mixture including a DNA polymerase and/or dNTPs, a buffer solution and at least one stabilizing agent and hydration reducing the solution mixture. The solution mixture is hydration reduced at... Agent: Cardinal Law Group Suite 2000

20080050747 - Articles having localized molecules disposed thereon and methods of producing and using same: Sequencing methods and compositions, substrates, devices and systems are provided. Methods include synthesizing a nascent nucleic acid sequence that is greater than 100 bases in length and sequencing the nucleic acids by detecting synthesis. Compositions and substrates that include polymerization complexes for the methods are included.... Agent: Quine Intellectual Property Law Group, P.C.

20080050743 - Binary signal detection assays: The present invention provides methods, kits and compositions for the detection of an analyte. The invention is particularly suited for the detection and quantification of analytes in solution. In the methods of the invention a complex is formed between two or more analyte specific probes (ASP) and an analyte. The... Agent: Agilent Techologies Inc

20080050738 - Detection of target nucleic acid: Methods for producing a target nucleic acid molecule from DNA encoding a gene comprising treating DNA from a higher organism with an agent that modifies cytosine to form derivative nucleic acid; and forming a modified nucleic acid having a reduced total number of cytosines compared with the corresponding untreated DNA,... Agent: Knobbe Martens Olson & Bear LLP

20080050739 - Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, i.e. aneuploidy. In addition, the present invention provides methods to determine when there are insufficient fetal cells for a... Agent: Wilson Sonsini Goodrich & Rosati

20080050730 - Early detection of hemangiosarcoma and angiosarcoma: A variety of methods, compositions and kits are provided for the early detection, diagnosis and treatment of hemangiosarcoma in dogs and angiosarcomas in humans.... Agent: Townsend And Townsend And Crew, LLP

20080050736 - Fluorescent affinity tag to enhance phosphoprotein detection and characterization: The invention relates to target-associative tags incorporating cysteamine as the target-associative moiety. The invention further relates to a method for producing a target-associative tag by addition of cysteamine as the target-associative moiety to another molecule or entity having a property or properties useful in discriminating or selecting between members of... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080050731 - Labeling and detection of nucleic acids: Provided in certain embodiments are new methods for forming azido modified nucleic acid conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling nucleic acids with an azide group.... Agent: Invitrogen Corporation C/o Intellevate

20080050741 - Messenger rna profiling: body fluid identification using multiplex reverse transcription-polymerase chain reaction (rt-pcr): This invention relates to a body fluids identification method and kit. A parallel, multiplex reverse transcription-polymerase chain reaction (RT-PCR) assay for the definitive identification of body fluids commonly encountered in forensic casework analysis, namely blood, saliva, semen, and vaginal secretions. The methodology is based on gene expression profiling analysis in... Agent: Law Offices Of Brian S Steinberger

20080050727 - Method of genotyping blood cell antigens and kit suitable for genotyping blood cell antigens: A method of genotyping blood cell antigens comprising subjecting DNA from an individual of a mammalian species to a multiplex Polymerase Chain Reaction (PCR) to amplify and detectably label a region of the locus of at least two different blood cell antigens which contains the site of nucleotide polymorphism of... Agent: Morrison & Foerster LLP

20080050732 - Methods and compositions for predicting drug responses: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.... Agent: Nixon Peabody LLP - Patent Group

20080050733 - Methods and compositions for predicting drug responses: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene.... Agent: Nixon Peabody LLP - Patent Group

20080050744 - Methods and compositions involving mirna and mirna inhibitor molecules: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors... Agent: Fullbright & Jaworski L.L.P.

20080050742 - Methods and reagents for combined pcr amplification: An oligonucleotide probe is disclosed, the probe including an oligonucleotide, a fluorescer molecule attached to a first end of the oligonucleotide and a quencher molecule attached to the opposite end of the oligonucleotide. The probe is rendered impervious to digestion by the 5′→3′ exonuclease activity of a polymerase and the... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080050728 - Mitigation of cot-1 dna distortion in nucleic acid hybridization: A novel method of suppressing non-specific cross-hybridization between repetitive elements present in nucleic acid probes and corresponding repetitive elements in the target nucleic acid by using DNA synthesized to contain a plurality of repetitive elements while avoiding low and single copy sequences.... Agent: Tracey S. Truitt Erickson & Kleypas, L.L.C.

20080050734 - Novel cdk11 molecules and uses thereof: The present invention relates to a novel serine threonine kinase. The invention also relates to vector, host cells, antibodies and recombinant methods for producing the Cdk11 polypeptide. In addition, the invention discloses therapeutic, diagnostic and research utilities for Cdk11 and related products.... Agent: Marshall, Gerstein & Borun LLP

20080050746 - Nucleic acid quantitation from tissue slides: This invention provides methods of quantitating nucleic acids from problematic samples, such as aged samples, formalin fixed samples, paraffin embedded samples, samples with aneuploid cells, and cells with fragmented nucleic acids. Methods include techniques to efficiently solublize the nucleic acids under non-denaturing conditions from preserved clinical samples without resort to... Agent: Quine Intellectual Property Law Group, P.C.

20080050735 - Nucleic acid testing method for point-of-care diagnostics and genetic self-monitoring: This invention describes a nucleic acid testing procedure in a form of portable device or a test kit for the purposes of clinical genetic testing, infectious disease diagnostics, biodefense, forensic analysis, paternity testing, pet and cattle breeding, food testing, etc. This testing does not include toxic chemicals and is simple... Agent: Elena Pushnova

20080050740 - Nutritional and exercise plan based on a person's individual genetic apo e genotype: A nutritional plan based on a person's individual genetic APO E genotype, which has been shown to be the number one gene affecting diet, cholesterol, heart disease, vascular dementia, Alzheimer's disease, and chronic illness, possibly autism, Parkinson's disease, and other neurological diseases, and that focuses on the right percentages of... Agent: Glenn Patent Group

20080050745 - Sugar chain synthesizing agent having beta1,3-n-acetyglucosaminyltransferase activity: The present invention provides a novel polypeptide having a β1,3-N-acetylglucosaminyltransferase activity, an agent for synthesizing a sugar chain comprising the polypeptide, a process for producing a sugar chain or a complex carbohydrate using the agent for synthesizing a sugar chain, DNA encoding the polypeptide, a process for producing the polypeptide,... Agent: Fitzpatrick Cella Harper & Scinto

20080050748 - Tissue analysis and kits therefor: This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. The analysis can be automated or manual. The invention also relates to kits... Agent: Heller Ehrman LLP

20080050751 - Nonhuman model animal of th2-mediated hyperimmune response: An object of the present invention is to provide a nonhuman model animal of Th2-mediated hyperimmune response lacking PIR-B gene function on its chromosome by which the Th2-mediated immune response mechanism and allergy onset mechanism in vivo can be analyzed and which is liable to suffer from not only hyper-response... Agent: Morgan & Finnegan, L.L.P.

20080050750 - Screening assay for inhibitors of trpa1 activation by a lower alkyl phenol: The invention relates an assay useful for screening and identifying compounds as modulators of lower alkyl phenol activation of TRPA1. Thymol, a lower alkyl phenol anti-infective and the active ingredient in, e.g., mouthwashes, is stringent and has an objectionable burning taste sensation. Thymol activates the transient receptor potential like ion... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080050752 - Methods of analyzing binding interactions: The present disclosure relates to methods of analyzing binding interactions between a binding component and a receptor component by translocating unbound and any bound components through a pore and detecting the unbound and bound components.... Agent: Dechert LLP

20080050755 - Method for screening for chemotherapeutic treatments for cancer: The present invention provides a method of screening for potential cancer chemotherapeutic and chemopreventive agents which act by inducing or mimicking the activity of Siah-1 in humans. This invention also provides methods of administering such agents to treat cancer by inducing or mimicking the activity of Siah-1, thus causing the... Agent: Madson & Austin

20080050756 - Methods for determining cellular response to stimuli: The present invention provides a method for determining cellular response to stimuli. The cells to be tested, for example, may be contained in a section of taste-bud containing lingual epithelium.... Agent: Viksnins Harris & Padys Pllp

20080050758 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Genentech, Inc.

20080050753 - Ceramidase gene: A neutral/alkaline ceramidase derived from a mammal; an antibody specifically binding thereto; a probe and primer which are capable of specifically hybridizing thereto; a method for producing the ceramidase by a genetic engineering means; a method for detecting the ceramidase or the gene; and a method of controlling an amount... Agent: Birch Stewart Kolasch & Birch

20080050754 - Diagnostic reagent and diagnostic reagent kit for hiv infection, method for manufacturing diagnostic reagent for hiv infection and method for detecting anti-hiv antibody: A diagnostic reagent for HIV infection is described. The diagnostic reagent comprises a first carrier particle for specifically detecting a first anti-HIV antibody and a second carrier particle for specifically detecting a second anti-HIV antibody different from the first anti-HIV antibody. On the first carrier particle, a first HIV antigen... Agent: Sughrue Mion, PLLC

20080050760 - Compositions and methods to co-localize luminophores with luminescent proteins: A method of measuring the enzymatic activity of a luciferase includes contacting a luminogenic protein, such as a luciferase, with a protected luminophore to form a composition; and detecting light produced from the composition. The protected luminophore provides increased stability and improved signal-to-background ratios relative to the corresponding unmodified coelenterazine.... Agent: Brinks Hofer Gilson & Lione

20080050763 - Identification of substances that inhibit nemo oligomerization: The present invention provides methods for screening for substances which inhibit the oligomerization of NEMO and/or IKK-related complexes and/or signaling pathways based on the interference with NEMO oligomerization... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080050762 - Methods and compositions for coupled luminescent assays: The invention provides methods for measuring the amount or activity of a component in a sample using a luminescent assay comprising a luciferase capable of generating light from a high-energy molecule. In one aspect, the invention provides methods for measuring the amount of NAD+ or the activity of an enzyme... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20080050765 - Method of immobilizing malate dehydrogenase on a substrate: Immobilization of malate dehydrogenase on a substrate using a glycerol solution containing malate dehydrogenase is achieved through dropping a mixed solution obtained by adding at least one selected from malic acid and malate to the glycerol containing malate dehydrogenase on the substrate, and drying it thereon. It is preferable to... Agent: Mcdermott Will & Emery LLP

20080050768 - Metabolic monitoring device: Systems, methods and devices for the monitoring of the metabolism and the health of cultured cells are disclosed. The devices simplify the loading of cells and enable loading under sterile conditions. The devices also allow for the culture, measuring and monitoring of the metabolism of a population of cells, and... Agent: Lathrop & Gage Lc

20080050766 - Plasmid having response to dioxins, transgenic cell for measuring dioxins, dioxins sensing method and biosensor using the same: A plasmid comprising a gene, which is reactive with dioxins and/or polycyclic aromatic hydrocarbons to thereby be activated (hereinafter referred to as DRE gene), and a secretory marker protein expressing gene disposed understream of the DRE gene. Further, there is developed a transgenic cell having this plasmid introduced therein which... Agent: Birch Stewart Kolasch & Birch

20080050767 - Transgenic animals expressing prkag3: Transgenic non-human animals that express the γ3 subunit of PRKAG are described, as well as methods of using the transgenic non-human animals as models for improving treatment, prevention, or diagnosis of diseases related to energy metabolism, including obesity, dyslipidemia, insulin resistance syndrome, and type 2 diabetes.... Agent: Fish & Richardson P.C.

20080050769 - Method for detecting bioparticles: This invention disclosed a method to detect bioparticles in the biological samples (stools, urine, or other body fluids). Bioparticles (e.g. virus, bacteria, and cells) often serve as carrier/indicator of pathogens and/or toxins. The method employs a substrate with interlaced comb-like electrodes on which a certain amount of sample mixed with... Agent: Jung-tang Huang

20080050771 - Process for the synthesis of cefaclor: The present invention relates to a process for the synthesis of cefaclor, which process comprises reacting 7-amino-3-chloro cephalosporanic acid (7-ACCA) with D-phenylglycine in activated form (PGa) in the presence of an enzyme in a reaction mixture to form cefaclor, wherein at least part of 7-ACCA and/or PGa are added to... Agent: Nixon & Vanderhye, PC

20080050772 - Granulocyte colony stimulating factor: remodeling and glycoconjugation of g-csf: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.... Agent: Morgan, Lewis & Bockius LLP (sf)

20080050773 - Novel peptide-forming enzyme gene: DNA and recombinant DNA that encode a peptide-forming enzyme, a method for producing a peptide-forming enzyme, and a method for producing a dipeptide are disclosed. A method for producing a dipeptide includes producing a dipeptide from a carboxy component and an amine component by using a culture of a microbe... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080050775 - Methods for recovering products from plants: Described are methods and compositions for producing and isolating desired products (for example, one or more protein, peptide, or pharmaceutical compound species) in transgenic plants engineered to produce the desired product(s). The desired products are isolated from the transgenic plants by contacting plant tissue with an enzyme preparation under conditions... Agent: Biotechnology Law Group C/o Portfioloip

20080050776 - Stable mutated pro nerve growth factors: The present invention relates generally to novel stable pro nerve growth factors (proNGFs) that are stable towards proteolysis by proteases such as furin, PACE4, and PC2. The novel proNGF molecules are prepared with multiple mutations at all the three major processing sites of the pro domain of the natural proNGF... Agent: Joseph A. Fuchs Rockey, Depke & Lyons, LLC

20080050777 - Methods for expression and purification of recombinant human growth hormone: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process... Agent: Attn: John W. Wallen, Iii Ambrx, Inc.

20080050779 - Fermentation process using faba beans as nitrogen source: The present invention describes a microbial fermentation process using a fermentation medium comprising a complex nitrogen source, wherein a substantial part of the nitrogen (N) that is supplied by the complex nitrogen source is provided by faba bean meal. The use of faba bean meal has a viscosity lowering effect... Agent: Nixon & Vanderhye, PC

20080050780 - Reversible terminator nucleotides and methods of use: Disclosed herein a reversible terminator nucleotides and methods of use.... Agent: Dechert LLP

20080050782 - Methods for making character strings, polynucleotides and polypeptides having desired characteristics: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.... Agent: Beyer Weaver LLP

20080050781 - Systems and methods for cooling in a thermal cycler: A device for performing polymerase chain reactions using cooling members not used in conventional thermal cyclers. A device for performing polymerase chain reactions may include a sample holder configured to receive a nucleic acid sample, a heating system configured to raise the temperature of the sample, a cooling system configured... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080050783 - Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound RNA, lipid-RNA complexes, lipoprotein (proteolipid)-RNA complexes, protein-RNA... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080050784 - Method for producing an l-amino acid: A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the L-amino acid using the bacterium is also described.... Agent: Cermak & Kenealy LLP Acs LLC

20080050785 - Method for producing an l-amino acid: A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the L-amino acid using the bacterium is also described.... Agent: Cermak & Kenealy LLP Acs LLC

20080050786 - Method for producing l-amino acids: The invention is directed to a process for producing an L-amino acid by fermenting a microorganism, wherein the expression of a lysC gene encoding a feed back resistant aspartokinase is enhanced by cloning a strong promoter/ribosome binding sequence.... Agent: Law Office Of Michael A. Sanzo, LLC

20080050787 - Method for manufacturing optically active tetrahydrothiophene derivative and method for crystallization of optically active tetrahydrothiophene-3-ol: to (R)-tetrahydrothiophene-3-ol denoted by formula (II). It comprises the steps of: (A) incubating the tetrahydrothiophene-3-one denoted by formula (I) in the presence of a strain, or a preparation of a cultured cell thereof, belonging to Penicillium, Aspergillus, or Streptomyces that is capable of said bioconversion; and (B) collecting the (R)-tetrahydrothiophene-3-ol... Agent: Jacobson Holman PLLC

20080050788 - Gamma-butyrobetaine hydroxylase originated from neurospora crassa: Disclosed is a polynucleotide encoding γ-butyrobetaine hydroxylase (γ-BBH) originating from Neurospora crassa. Also disclosed are a recombinant vector comprising the polynucleotide, a transformant transformed with the recombinant vector, γ-BBH encoded by the polynucleotide, and a method of preparing L-carnitine, which comprises hydroxylating γ-butyrobetaine using γ-BBH encoded by the polynucleotide.... Agent: Casimir Jones, S.c.

20080050789 - Process for the preparation of amides: A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Micro-organisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process.... Agent: Baker Botts L.L.P.

20080050790 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross P.C.

20080050791 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross P.C.

20080050792 - Processes for catalytic conversion of lignin to liquid bio-fuels and novel bio-fuels: Processes for conversion of lignin to liquid products such as bio-fuels and fuel additives are disclosed and described. A process for conversion of a lignin material to bio-fuels can include subjecting the lignin material to a base catalyzed depolymerization reaction to produce a partially depolymerized lignin. The partially depolymerized lignin... Agent: Workman Nydegger

20080050793 - Method of drying biological material: A method for producing foams containing biological materials is described. A solid or semi-solid paste is formed by combining biologically active material with a protecting agent in an aqueous solvent. The paste formed is allowed to set, and may optionally then be apportioned into the desired shape. The paste may... Agent: Mathews, Shepherd, Mckay, & Bruneau, P.A.

20080050794 - Optoinjection methods: Optoinjection method for transiently permeabilizing a target cell by (a) illuminating a population of cells contained in a frame; (b) detecting at least one property of light directed from the frame; (c) locating a target cell by the property of light; and (d) irradiating the target cell with a pulse... Agent: Knobbe Martens Olson & Bear LLP

20080050795 - Mixture of at least two different antibodies specific for predetermined antigens and use of the mixture: A mixture of isolated or synthetic affinity molecules in a liquid carrier is disclosed. The mixture comprises at least two different affinity molecules, each with affinity for a predetermined analyte, for use in a single or multi flow cell piezoelectric crystal micro balance apparatus. Each isolated or synthetic affinity molecule... Agent: Bacon & Thomas, PLLC

20080050796 - Nucleic acids and polypeptides involved in the production of cryptophycin: The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the invention to produce cryptophycins.... Agent: Fish & Richardson P.C.

20080050797 - Human cyclin-dependent kinase (hpnqalre): A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for treating proliferative disorders and neoplasia are also provided.... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20080050798 - Enzymes for the preparation of amides: A novel biotechnological process for the preparation of nitriles, starting from amides, is described. Microorganisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for this process.... Agent: Baker Botts L.L.P.

20080050799 - Liquid crystals with reduced toxicity and applications thereof: Liquid crystal compositions that exhibit little or no toxicity with respect to cells include liquid crystals with chemical functional groups such as fluorine atoms, fluorophenyl groups, or difluorophenyl groups. Liquid crystals with little or no toxicity to cell lines may be added to cell culture media or added to components... Agent: Foley & Lardner LLP

20080050800 - Method and apparatus for a multi-system bioenergy facility: An alternative energy generating apparatus is provided for generating electricity, the apparatus includes an electric generating apparatus, wherein the electric generating apparatus produces flue gasses, at least one anaerobic digester adapted to supply biogas to the electric generating apparatus and at least one bioreactor configured to receive a least a... Agent: Schwegman, Lundberg & Woessner, P.A.

20080050802 - Biofilter: A biofilter for use in treating contaminated gasses is provided with a container having a layer of rubber particulate, which serves as a filter media. One preferred source of the rubber particulate is recycled tires. The rubber particulate provides a platform for the growth and maintenance of a microbial ecosystem... Agent: Thomte Law Office, L.L.C.

20080050801 - Methods and systems for biological treatment of flue gas desulfurization wastewater: Systems and methods of treating flue gas and wastewater generated by treating the flue gas are disclosed and include introducing the flue gas, a flue gas treatment fluid that removes sulfur dioxide from the flue gas; and an organic acid conditioning agent into a wet-oxidation scrubber/absorber; introducing FGD scrubber wastewater... Agent: Ip Group Of Dla Piper US LLP

20080050803 - Integrated airborne substance collection and detection system: An integrated collection and detection system is configured to monitor the ambient air for specific particles, such as toxins and pathogens. An air collector captures airborne particles and outputs a fluid sample including the captured particles in a fluid solution. The collection and detection system includes a control module configured... Agent: Haverstock & Owens LLP

20080050804 - Moving microdroplets in a microfluidic device: The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations within the microfluidic. The system includes a substrate which forms a fluid network through which fluid flows, and a... Agent: Fish & Richardson P.C.

20080050805 - Tissue board assembly: A Tissue Board Assembly for collecting, storing, preparing and preserving tissue and/or bone.... Agent: Berkeley Law & Technology Group, LLP

20080050806 - Aerobic waste treatment system: An aerobic waste treatment system, such as a composting system, comprising a movable push wall (20). The movable push wall (20) is preferably part of a container (10). In use of the aerobic waste treatment system, waste is heaped against the movable push wall (20) to build a waste heap... Agent: Grossman, Tucker, Perreault & Pfleger, PLLC

20080050808 - Dna modular cloning vector plasmids and methods for their use: A group of modular cloning vector plasmids for the synthesis of a transgene or other complicated DNA construct, by providing a backbone having docking points therein, for the purpose of gene expression or analysis of gene expression. The invention is useful for assembling a variety of DNA fragments into a... Agent: Sughrue Mion, PLLC

20080050807 - Gene encoding alkaline liquefying alpha-amylase: g

20080050809 - Novel human kinases and polynucleotides encoding the same: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.... Agent: Lexicon Pharmaceuticals, Inc.

20080050811 - Testicular carnitine transporter and its gene: It is intended to identify and provide a novel carnitine transporter gene participating in carnitine transport in the testis and epididymis and carnitine transporter which is a protein encoded by the gene. A protein comprising the amino acid sequence represented by SEQ ID NO:1 or an amino acid sequence derived... Agent: Edwards Angell Palmer & Dodge LLP

20080050810 - Variants of humanized anti-carcinoma mab cc49: The invention is directed towards mouse-human chimeric variants of CC49 monoclonal antibodies with minimal murine content. A first aspect of the invention provides CDR variants of humanized monoclonal antibody (HuCC49) in which less than all six (three heavy chain and three light chain) Complementarity Determining Regions (CDRs) of CC49 are... Agent: Klarquist Sparkman, LLP

20080050812 - Micropositioning cells for tissue engineering: The present invention features methods for specifically micropositioning cells on a substratum. Cell-adhesive substances that bind to naturally-occurring or artificially-attached cell-surface moieties are deposited onto the substratum (e.g., using an inkjet printer), after which cells are incubated with the substratum such that they attach to the substratum via the cell-adhesive... Agent: Needle & Rosenberg, P.C.

20080050813 - Derivation and culture of human embryo-derived cells: The present invention concerns methods for deriving and culturing embryonic cells and in particular to methods for maintaining the undifferentiated state of stems cells and cell lines in culture. The invention also concerns cells and cell lines derived by the methods of the invention.... Agent: Merchant & Gould PC

20080050814 - Procurement, isolation and cryopreservation of fetal placental cells: Methods, processes and systems for procuring, isolating and cryopreserving fetal placental cells are provided. A population of fetal placental cells is also provided.... Agent: John W. Goldschmidt, Jr. Esquire Dilworth Paxon LLP

20080050815 - Method of oocyte cryopreservation including piercing the zona pellucida prior to vitrification: The present invention relates to the cryopreservation and preparation of warmed oocytes for fertilization. Cryopreservation of oocytes using vitrification methods is disclosed. Exemplary techniques include making a vent in the zona pellucida surrounding the oocyte; contacting the oocyte with a vitrification solution comprising at least one cryoprotectant; and vitrifying the... Agent: Mcdermott Will & Emery LLP

20080050816 - Cell culture chip with a iii-v nitride compound adhesion layer and applied thereof: The present invention discloses a cell culture chip, which comprising a cell adhesion layer with a III-V nitride compound. The cell adhesion layer according to the invention can improve the adhesion effect between the cultured cell and the cell adhesion, enhance the cell growth and differentiation, and reduce the cell... Agent: Birch Stewart Kolasch & Birch

20080050817 - Basal medium for es culturing: The present invention discloses a medium for a serum-free medium capable of culturing ES cells for a long period while maintaining their undifferentiated state without using feeder cells, and a basal medium for producing the medium thus described. The basal medium of the present invention is characterized by that it... Agent: Alston & Bird LLP

20080050818 - Polynucleotide encoding a maize herbicide resistance gene and methods for use: This invention relates to polynucleotide sequences encoding a gene that can confer resistance to at least one herbicide. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to at least one herbicide, and methods of making said plants... Agent: Pioneer Hi-bred International, Inc.

20080050819 - Constructs for marker excision based on dual-function selection marker: The invention relates to improved construct and methods for eliminating maker sequences from the genome of plants, based on dual-function selection marker which—depending on the employed compound—can act as both negative and counter-selection marker.... Agent: Connolly Bove Lodge & Hutz, LLP

20080050821 - Alfalfa plants having improved fast recovery after harvest and methods for producing same: The invention provides alfalfa plants having improved standability and/or fast recovery after spring green-up or after harvest and methods for producing such plants. Such alfalfa plants provide increased annual yield of high quality forage.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080050820 - Casein kinase stress-related polypeptides and methods of use in plants: A transgenic plant transformed by a casein kinase Stress-Related Polypeptide (CKSRP) coding nucleic acid, wherein expression of the nucleic acid sequence in the plant results in increased tolerance to environmental stress as compared to a wild type variety of the plant. Also provided are agricultural products, including seeds, produced by... Agent: Basf Corporation

20080050822 - Polynucleotide encoding a maize herbicide resistance gene and methods for use: This invention relates to polynucleotide sequences encoding a gene that can confer resistance to at least one herbicide. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to at least one herbicide, and methods of making said plants... Agent: Pioneer Hi-bred International, Inc.

20080050823 - Polynucleotide encoding a maize herbicide resistance gene and methods for use: This invention relates to polynucleotide sequences encoding a gene that can confer resistance to at least one herbicide. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to at least one herbicide, and methods of making said plants... Agent: Pioneer Hi-bred International, Inc.

20080050824 - Polynucleotide encoding a maize herbicide resistance gene and methods for use: This invention relates to polynucleotide sequences encoding a gene that can confer resistance to at least one herbicide. It further relates to plants and seeds of plants carrying chimeric genes comprising said polynucleotide sequences, which enhance or confer resistance to at least one herbicide, and methods of making said plants... Agent: Pioneer Hi-bred International, Inc.

20080050826 - Method for improving corn starch extractability: The present invention relates to the transformation of maize with a grain softness-enhancing gene for improving corn starch extractability. The invention more particularly concerns the reduction of wet milling time using genetically transformed corn that expresses puroindoline.... Agent: Connolly Bove Lodge & Hutz, LLP

20080050825 - Method for production of transgenic plants with increased pathogenic resistance by altering the content and/or activity of actin-depolymerising factors: The invention relates to a method for production of transgenic plants and/or plant cells with increased pathogenic resistance, whereby the transgenic plants or plant cells have an altered content or an altered activity of at least one actin-depolymerising factor (ADF) with relation to the wild type. The invention also relates... Agent: Connolly Bove Lodge & Hutz, LLP

20080044805 - Biopolymer-dye complex and use as a bioassay: The present disclosure provides rapid, simple, robust and sensitive label and label-free assays for use in drug discovery, bioagent detection and medical diagnostics as well as means for reading such assays. The assays disclosed in the present disclosure use the formation, disruption and destruction of self-assembling fluorescent dye:biopolymer complexes to... Agent: Gonzales Patent Services

20080044807 - Method of detecting hepatitis c virus: A method of treating samples containing hepatitis C virus (HCV) which method comprises treating HCV-containing samples with a treating agent containing (1) an acidifying agent, and (2) a protein-denaturing agent, or an amphoteric surfactant or a cationic surfactant having both a straight chain alkyl group of 10 or more carbon... Agent: Foley And Lardner LLP Suite 500

20080044808 - West nile virus antigen and assay: The present invention provides for a polypeptide comprising a fragment of the West Nile Virus E protein, wherein the E protein fragment consists of residues 1-428. The invention also provides for polynucleotides encoding this protein and host cells transformed genetically to express this protein. More particularly, the invention provides for... Agent: Klauber & Jackson

20080044813 - Amp ligation assay (ala): The present invention relates to a method, reagent and kit for detecting ligase-catalyzed joining of nucleic acid ends, and any analyte related thereto, such as a ligase, or a substrate or cofactor thereof. More specifically, the invention relates to a method and kit for detecting the presence or amount of... Agent: Kristian Jansson

20080044816 - Assay for sars coronavirus by amplification and detection of the replicase sequence: Primers and probes derived from SARS-CoV nucleic acid that facilitate detection and/or quantification of the replicase gene are disclosed. The disclosed sequences may be used in a variety of amplification and non-amplification formats for detection of SARS-CoV infection.... Agent: David W Highet Becton Dickinson And Company

20080044823 - Common module profiling of genes: A system for profiling a genomic sequence comprising assigning modules to a genome, wherein each module has a defined sequence characteristic and the genome is divided into modules; assigning a value or weight to a module for a given profile, wherein the presence of one or more modules in a... Agent: Morgan, Lewis & Bockius LLP (sf)

20080044818 - Diagnositic agent for malignant melanoma: An object of the present invention is to provide a novel and clinically useful diagnostic agent for malignant melanoma. The present invention provides a diagnostic agent for malignant melanoma, which comprises an antibody against GPC3, or a probe or a primer capable of detecting GPC3 expression.... Agent: Greenblum & Bernstein, P.L.C

20080044819 - Genetic reference materials: The invention provides a genetic reference standard with at least one human genetic reference sequence (having a human DNA sequence containing at least one genetic variant whose presence in the DNA of a human subject is indicative of a pathological condition, a predisposition to a pathological condition, or a predisposition... Agent: Knobbe Martens Olson & Bear LLP

20080044815 - Genetic screen for interaction interface mapping: The present invention provides improved reverse hybrid assay methods for identifying amino acid residues within a protein that are required for its interaction or physical association with another protein, wherein disruption of an interaction between a protein of interest and its binding partner protein is assayed for a library of... Agent: Cozen O'connor, P.C.

20080044812 - Melting temperature dependent dna amplification: A method for the selective amplification of at least one target nucleic acid in a sample comprising a mixture of at least one target nucleic acid and at least one non-target nucleic acid. The method comprises: a nucleic acid denaturation step, wherein the denaturation step is carried out at a... Agent: Sughrue Mion, PLLC

20080044817 - Methods for producing recombinant proteins: The present invention provides a method for controlling the partitioning of a recombinant protein between the supernatant and the periplasm in E. coli host cell cultures wherein expression of the recombinant protein by said cells is under the control of an inducible system, which method comprises: a) providing an E.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080044821 - Nucleic acid array having fixed nucleic acid anti-probes and complementary free nucleic acid probes: A process for identifying a complementary nucleic acid probe to a target nucleic acid involves forming an array of spots where each spot of the array has an immobilized nucleic acid anti-probe to which is hybridized a nucleic acid probe. The array of the anti-probe-probe complex is denatured. The nucleic... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20080044822 - Nucleic acid array with releaseable nucleic acid probes: A process is provided for identifying a complementary target nucleic acid. The process includes the hybridization of a nucleic acid probe to a carrier to form a nucleic acid probe-carrier complex. The complex is placed in a compartment bounded by a media permeable to the nucleic acid probe and exclusive... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20080044814 - Reagents and methods for detecting severe acute respiratory syndrome coronavirus: This invention provides reagents and methods for detecting the severe acute respiratory syndrome coronavirus (SARS CoV). This invention also provides related compositions, kits, systems, and computers.... Agent: Roche Molecular Systems Inc Patent Law Department

20080044837 - Receptor modulators: Method of identifying a modulator of CD28 comprising comparing a structural model of a candidate modulator with a structural model of CD28 to thereby determine whether the modulator will bind to CD28, wherein the structural model is derived from, or comprises, structural coordinates of a crystal of: (i) CD28, (ii)... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080044845 - Method for obtaining a singular cell model capable of reproducing in vitro the metabolic idiosyncrasy of humans: The method is based on the use of expression vectors coding for the sense and anti-sense mRNA of the Phase I drug biotransformation enzymes showing a greatest variability in humans for transforming cells expressing reductase activity. Such vectors can modulate (increase or decrease) the individualised expression of an enzyme without... Agent: Moore & Van Allen PLLC

20080044844 - Populations of cells and devices and systems including same: A population of cells is provided. The population of cells comprising at least two subpopulations of cells, wherein a first subpopulation of the at least two subpopulation of cells includes a first reporter expression construct being expressible in a cell of the first subpopulation when exposed to a first analyte... Agent: Martin D. Moynihan Prtsi

20080044849 - Method for cell analysis: The invention describes a method for cell analysis in which the cells to be analyzed are adhesively applied to a slide and stained with a first stain. A first digital image is then taken and stored of the cells applied to the slide and stained. After the first digital image... Agent: Trexler, Bushnell, Giangiorgi, Blackstone & Marr, Ltd.

20080044860 - Polyketides and their synthesis: Macrolides particularly erythromycins and azithromycins, having O-mycaminosyl or O-angolosaminyl groups, particularly at the 5-position, are produced using a gene cassette comprising a combination of genes which, in an appropriate strain background, are able to direct the synthesis of mycaminose or angolosamine and to direct its subsequent transfer to an aglycone... Agent: Dann, Dorfman, Herrell & Skillman

20080044861 - Methods for recovering isoflavones from fermentation processes: A method for obtaining improved yields of isoflavones from spent fermentation beer produced by Actinomycetes grown on leguminous plant materials is demonstrated. This method involves conversion of isoflavone biotransformation products to isoflavone aglycones followed by isolation of the isoflavone aglycones. Formation of the biotransformation products had previously limited the production... Agent: Thompson Coburn, LLP

20080044862 - Nucleic acid linkers and use thereof in gene synthesis: The present invention relates to a single-stranded nucleic acid molecule for use in a method for the production of a nucleic acid, whereby the nucleic acid molecule comprises a part A and a part B, whereby part A comprises a sequence, which corresponds at least to a partial sequence of... Agent: Dykema Gossett PLLC

20080044803 - Platelet additive solution: Disclosed is a platelet additive solution (PAS) comprising a viscosity increasing agent. The use of a PAS comprising such a viscosity increasing agent, especially at concentrations effective to achieve a viscosity similar to that of blood plasma, promotes platelet recovery during extraction from pooled buffy coats and provides for easier... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20080044804 - Compositions and methods for detection and isolation of phosphorylated molecules: The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and... Agent: Invitrogen Corporation C/o Intellevate

20080044806 - Orientia tsutsugamushi truncated recombinant outer membrane protein (r47) and (r56) vaccines diagnostics and therapeutics for scrub typhus: A scrub typhus diagnostic method and vaccine using a composition comprising truncated r47 protein and truncated r56 protein is disclosed. Vaccines composed of r56 protein variants are also disclosed. Methods of reducing HIV viral loads using r47 and r56 proteins and antibodies raised against r47 and r56 are also disclosed.... Agent: Naval Medical Research Center Attn: (code 00l)

20080044811 - Aza-benzazolium containing cyanine dyes: Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject dyes are virtually non-fluorescent when diluted in aqueous solution, but exhibit bright fluorescence when... Agent: Invitrogen Corporation C/o Intellevate

20080044809 - Detection method for human pappilomavirus (hpv) and its application in cervical cancer: Embodiments of the invention provide methods, assays, and kits for detecting HPV infection and HPV associated epithelial cell abnormalities, most notably those associated with pre-malignant and malignant epithelial cell lesions. Detection of HPV DNAs, genomes, and/or oncoproteins by nucleic acid hybridization assays and immunological assays can be used in early... Agent: Patterson & Sheridan, L.L.P.

20080044810 - Means and methods for monitoring protease inhibitor antiretroviral therapy and guiding therapeutic decisions in the treatment of hiv/aids: This invention relates to antiviral drug susceptibility and resistance tests to be used in identifying effective drug regimens for the treatment of human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS), particularly treatment regimens including a protease inhibitor. The invention further relates to the means and methods of monitoring... Agent: Jones Day

20080044829 - Biosensor utilizing pigment-synthesizing gene of a purple non-sulfur bacterium and a method for preparing such a biosensor: A biosensor where measurement is able to be conducted by simpler operations, cost is less expensive and specific chemical substance is able to be visually detected is provided. In accordance with the present invention, there is provided a biosensor for the detection of a specific chemical substance, characterized in that... Agent: Kennedy Covington Lobdell & Hickman, LLP

20080044828 - Cudr as biomarker for cancer progression and therapeutic response: Disclosed is a novel human gene designated CUDR. Provides is also a CUDR gene as a biomarker in the diagnosis of human cancers and a cancer therapy.... Agent: Knobbe Martens Olson & Bear LLP

20080044833 - Diagnostic pkm2 methods and compositions: This invention provides a method for diagnosing or prognosing ovarian cancer by detecting the level of expression of pyruvate kinase isoenzyme M2 or fragment thereof in a subject. Applicants report that overexpression of this protein or fragment thereof is correlative with the presence of ovarian cancer in mammals. Applicants also... Agent: Genzyme Corporation Legal Department

20080044824 - Expressed profile of thyroid cancer: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with thyroid cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization... Agent: Casimir Jones, S.c.

20080044827 - Imaging of enzyme activity: This invention relates to biochemistry and magnetic resonance imaging.... Agent: Fish & Richardson PC

20080044820 - La1 - the genome of a lactobacillus strain: The present invention pertains to the use of the DNA sequence of a Lactobacillus johnsonii strain, in particular to its genomic sequence for elucidating interactions of micro-organism with hosts they colonize, and moreover for elucidating the basis of probiotic properties exhibited by such strain. In addition, the present invention also... Agent: Bell, Boyd & Lloyd LLP

20080044835 - Mammalian chemokine reagents: Novel chemokines from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokines. Chemokine receptors are also provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20080044825 - Method for modulating the evolution of a polypeptide encoded by a nucleic acid sequence: A method for modulating the ability of a gene to mutate by analyzing codon usage within the gene and selecting a synonymous nucleotide sequence with a higher, lower or different capacity to mutate. The method permits widening and optimization of the evolutionary landscape of a protein. A computer-implemented method for... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080044832 - Method of determining the prognosis of human cancer: The invention provides methods and kits of diagnosing or determining the prognosis of a cancer in a mammal comprising determining the methylation status of the (15)-Lipoxygenase type 1 (15-LO-1) promoter in the mammal's tissue, specifically, the methylation status of the 10th CpG dinucleotide of the 15-LO-1 promoter as defined by... Agent: Leydig Voit & Mayer, Ltd

20080044831 - Nph6 nucleic acids and proteins: The present invention relates to Nephronophthisis, in particular to the NPHP6 protein (nephrocystin-6) and nucleic acids encoding the NPHP6 protein. The present invention also provides assays for the detection of NPHP6, and assays for detecting NPHP6 polymorphisms and mutations associated with disease states.... Agent: Casimir Jones, S.c.

20080044836 - Nucleic acid analysis using non-templated nucleotide addition: One embodiment of the invention is a method of producing an oligonucleotide extended by a single nucleotide base. An oligonucleotide and an extension terminating nucleotide are mixed with an enzyme having terminal transferase activity. The reaction produces an oligonucleotide extended by a single base. The extended oligonucleotide may be used... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080044826 - Rapid and sensitive assay for the detection and quantification of coregulators of nucleic acid binding factors: Biosensors and methods to determine the activity of any and all nucleic acid binding factors, proteins, cellular events, nucleic acid binding protein coregulators, or fragments thereof, based upon the stabilization of the interaction of two nucleic acid components, which together comprise a complete nucleic acid binding element, by the binding... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080044834 - Three-component biosensors for detecting macromolecules and other analytes: The invention generally provides three-component molecular biosensors. The molecular biosensors are useful in several methods including in the identification and quantification of target molecules.... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080044830 - Three-dimensional nanostructured and microstructured supports: The invention relates to functional elements that comprise, disposed on a support, microstructures containing biofunctionalized nanoparticles, methods for producing these functional elements and use of the same.... Agent: Dickstein Shapiro LLP

20080044839 - Methods and compositions for diagnosing lung cancer: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ubiquilin 1 markers for cancer.... Agent: Casimir Jones, S.c.

20080044838 - Molecular spacer arm, process for the production thereof and uses on an analytical chip comprising molecules or biomolecules: in which X0, X4═C, O, S, Se, N, P, As; X1-3═C, O, N, S, Se, P, As, or C1-6 aryl or heteroaryl; Z1-2═C—R, Si—R, N, P and As, where R═C1-6 alkyl; R1-3═H, or C1-6 alkyl, aryl or heteroaryl; [Gp]=protective group for >N; n, m and p=integers ≧1; [Sup]=H or a... Agent: Hutchison Law Group PLLC

20080044840 - Antibodies against cancer antigen tmeff2 and uses thereof: Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.... Agent: Pdl Biopharma, Inc. Attn: Legal Department

20080044841 - Method and kit for rapid analysis of acidophilic microorganisms: The object of the present invention is to provide a rapid method for detection of the presence of acidophilic microorganisms in aqueous samples, such as acid mine drainages or acid rock drainages, bioleaching solutions or solutions from heap leaching; or in solid samples, such as minerals or concentrates subjected to... Agent: Gottlieb Rackman & Reisman PC

20080044842 - Biological test strip: A test sensor (10) for use in the determination of an analyte in a liquid sample. The test sensor (10) includes a base (14), a lid (12), and a test membrane (18) adhered to the base. A reagent (20) is contained within the test membrane (18). A mesh strip (22)... Agent: Nixon Peabody LLP

20080044843 - Biomarkers for chronic obstructive pulmonary disease: Detection of expression of biomarkers (e.g., protein analytes) whose regulation is perturbed in COPD patients can be used to diagnose COPD, to confirm a diagnosis of COPD, and to assess or prognose progression of COPD. Test substances can be screened for the ability to affect levels of protein analyte expression,... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20080044847 - Blood-brain barrier model: A method of creating a multicellular blood-brain barrier model is disclosed. In one embodiment, the method comprises culturing primary brain microvascular endothelial cells or embryonic stem cell-derived endothelial cells upon a permeable support in the presence of neural progenitor cells.... Agent: Quarles & Brady LLP

20080044846 - Method and kit for the microbiological determination of vitamins in substance mixtures: Method for the quantitative determination of vitamins, amino acids, or other substances necessary for life, in a substance mixture, whereby in the culture container, the cavities of a microtitration plate, in each case a predetermined number of vital cells of a suitable microorganism are prepared in a permanent manner. For... Agent: James C. Lydon

20080044848 - Placental niche and use thereof to culture stem cells: The present invention provides methods for culturing, expanding and differentiating stem cells, particularly human embryonic stem cells. The methods comprise culturing the stem cells for a period of time on a collagen biofabric, particularly a collagen biofabric derived from the amniotic membrane, chorion, or both, from mammalian placenta.... Agent: Jones Day

20080044851 - Compositions and methods for removal of dna from a sample: The present invention provides compositions and methods for digesting DNA. In particular, the present invention provides enzymes mixtures that provide enhanced DNA digestion and methods of using the enzyme mixtures to eliminate or reduce undesired DNA molecules from a sample of interest.... Agent: Medlen & Carroll, LLP

20080044850 - Membrane bioreactor: The invention provides a membrane comprising a gel reinforced by a support. The membrane has opposing surfaces and a thickness between said surfaces. The gel communicates between the opposing surfaces and allows diffusion of a nutrient solution through the membrane. A bioreactor is also provided, comprising a membrane-supporting structure, and... Agent: Foley And Lardner LLP Suite 500

20080044852 - Compositions and methods of preparation thereof: The present invention provides biological compositions and methods for making the same.... Agent: Katherine A. Jackson Huebsch Medtronic, Inc.

20080044854 - Site-specific incorporation of amino acids into molecules: The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified aminoacyl-tRNA synthetase to charge the non-natural amino acid to a the corresponding tRNA. In certain embodiments, the tRNA is also modified such that the... Agent: Seed Intellectual Property Law Group PLLC

20080044853 - Stably maintained multiple copies of at least two orf in the same orientation: The present invention relates to a method for constructing a host cell expressing a polypeptide of interest from at least two ORF's stably integrated onto the chromosome of the host cell comprising the steps of: a) providing the at least two ORF's encoding the same polypeptide, wherein the at least... Agent: Novozymes North America, Inc.

20080044855 - System for regulated and enhanced baculovirus mediated transient transgene expression in mammalian cells: A baculovirus-based expression system under control of CR5 promoter improves expression of transgenic nucleic acid molecules in mammalian cells. It also provides a platform for regulated expression of transgenic nucleic acid molecules in mammalian cells.... Agent: National Research Council Of Canada 1200 Montreal Road

20080044856 - Thermostable proteins and methods of making and using thereof: The present invention relates to functional, modified glucose-galactose binding proteins (GGBPs), that have a greater melting temperature (Tm) than a reference GGBP. The present invention also relates to biological sensors, e.g., glucose sensors, comprising these thermostable GGBPs. The present invention also relates to nucleic acids encoding these thermostable GGBPs.... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20080044859 - Fibroblast growth factor receptor-like molecules and uses thereof: The present invention provides Fibroblast Growth Factor Receptor-Like (FGFR-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing FGFR-L polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases,... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080044857 - Methods for making and using mass tag standards for quantitative proteomics: Disclosed are methods for producing peptide standards for quantitative proteomics. In one disclosed embodiment, chimeric polypeptides that are a combination of mass tags for multiple proteins are expressed in a host cell that is grown on an isotopically-altered medium. The mass tags in the chimeric polypeptide are separated by specific... Agent: Klarquist Sparkman, LLP

20080044858 - Methods for producing biological substances in enzyme-deficient mutants of aspergillus niger: The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent Aspergillus niger strain in a medium suitable for the production of the heterologous biological substance, wherein (i) the mutant strain comprises a first nucleotide sequence encoding the heterologous biological substance... Agent: Novozymes, Inc.

20080044863 - Method for producing purine nucleoside by fermentation: A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated repressor of purine nucleotide biosynthesis encoded by purR, a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080044864 - Method of amplifying nucleic acid from a cell using a nonplanar solid substrate: Provided is a method of amplifying nucleic acid from a comprising: contacting a cell-containing sample with a nonplanar solid substrate in a liquid medium having a pH range of 3.0-6.0 to attach the cell to the solid substrate; washing the nonplanar solid substrate to remove materials that are not attached... Agent: Cantor Colburn, LLP

20080044865 - Production of dha in microalgae in low ph medium: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium... Agent: Sheridan Ross P.C.

20080044866 - Production of dha in microalgae in low ph medium: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium... Agent: Sheridan Ross P.C.

20080044867 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS... Agent: Sheridan Ross P.C.

20080044868 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross P.C.

20080044869 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross P.C.

20080044870 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross PC

20080044871 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross PC

20080044872 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross P.C.

20080044873 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross PC

20080044874 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross P.C.

20080044875 - Solventless extraction process: The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing water soluble compound and/or materials by washing the lysed cell mixtures with aqueous... Agent: Sheridan Ross P.C.

20080044876 - Solventless extraction process: The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing water soluble compound and/or materials by washing the lysed cell mixtures with aqueous... Agent: Sheridan Ross P.C.

20080044877 - Process for producing ethanol: A process for producing ethanol from a fibrous lignocellulosic raw material. After pre-treatment of the raw material, the fibrous fraction is first hydrolysed at high consistency and then the modified material is subjected simultaneously to continued hydrolysis with a cellulase and to ethanol fermentation in a fermentation mixture. Fermentation is... Agent: Sughrue Mion, PLLC

20080044878 - Novel promoters: The present invention provides a production method of a copolymeric polyester which comprises culturing an ACT1 gene promoter shown under SEQ ID NO: 9, a GAP3 gene promoter shown under SEQ ID NO: 10; a PMA1 gene promoter shown under SEQ ID NO: 11, and, a TEF1 gene promoter shown... Agent: Kenyon & Kenyon LLP

20080044879 - Systems and methods of voltage-gated ion channel assays: Systems and methods are provided for optically measuring ion concentrations in biological samples. The systems and methods employ polymer-based optical ion sensors that include ion-selective ionophores and a pH sensitive chromionophore. Electrodes are providing for electrically stimulating the biological samples.... Agent: Ropes & Gray LLP Patent Docketing 39/41

20080044880 - Method of and apparatus for separating microorganisms from sample using electrodialysis and microorganism capturing means: A method of separating microorganisms from a sample includes introducing a sample into an apparatus which controls a concentration of at least one salt, the apparatus includes a reaction chamber defined between a cation exchange membrane and an anion exchange membrane, a first electrode chamber defined between the anion exchange... Agent: Cantor Colburn, LLP

20080044881 - Advanced indolinone based protein kinase inhibitors: Hydroxy carboxy pyrrolyl-indolinone derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.... Agent: The Scripps Research Institute

20080044882 - Oxidation by hydrogen peroxide: The present invention provides a method of carrying out an oxidation reaction catalysed by a monooxygenase enzyme and using hydrogen peroxide as an oxidant, in which reaction a low level of oxidation damage of the monooxygenase occurs, said method comprising producing the hydrogen peroxide simultaneously with the oxidation reaction, wherein... Agent: Fulbright & Jaworski L.l.p

20080044883 - Methods and compositions for amplification of dna: The invention provides an Enzyme Blend comprising a DNA polymerase and a DNA repair enzyme. Methods and kits for amplification of DNA that is damaged, undamaged, or suspected of being damaged are also provided.... Agent: Senniger Powers (sgm)

20080044884 - Method and device for separating cells from a sample using a nonplanar solid substrate: Provided is a method and device for separating a cell from a sample. The method comprises contacting a nonplanar solid substrate with a cell-containing sample in a liquid medium having a pH of 3.0 to 6.0.... Agent: Cantor Colburn, LLP

20080044885 - Method of separating microorganism using nonplanar solid substrate and device for separating microorganism using the same: Provided is a method of separating microorganisms from a sample including contacting the sample containing microorganisms with an inorganic ion exchange material such that the sample reacts with the inorganic ion exchange material, and contacting the reacted sample with a means for capturing microorganisms.... Agent: Cantor Colburn, LLP

20080044886 - Genetically encoded fluorescent coumarin amino acids: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the... Agent: Quine Intellectual Property Law Group, P.C.

20080044887 - Meandering channel fluid device and method: Methods and devices of performing reactions for which presence of light is desirable are provided. Biological or chemical materials such as algae are put in a chamber shaped as a meandering fluid channel. The algae can be combined with biomass such as human or animal waste and then subject to... Agent: Enrica Bruno Patent Law

20080044888 - Biofilter system and method for purifying gases escaping from a gully hole: The invention relates to a method for purifying gases escaping from a gully hole (1), particularly escaping from a sewer (8) guided at the bottom (7) of the gully hole (1) by means of a biofilter that is arranged inside the gully hole (1) in such a manner that the... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20080044889 - Landfill biofiltration system and methods for removal of gas-phase pollutants and contaminants: Biochemical decomposition of undesirable gaseous contaminants, including nitrogen oxides, VOC's, carbon monoxide and sulfur oxides, and malodorous contaminants, is achieved by passing a gas stream through a managed landfill providing microbiological activity capable of degrading the contaminants. Gases suitable for treatment include fuel combustor exhaust, landfill gases, putrescent gases and... Agent: Cyr & Associates, P.A.

20080044890 - Interchangable sleeve for enhancing proliferation of cells in a rotating bioreactor: An interchangeable sleeve for enhancing proliferation of cells in a rotating bioreactor is disclosed with the interchangeable sleeve having a substantially cylindrical and substantially rigid electrical conductive material wound in a cylindrical shape and capable of being connected to a pulsating time varying electromagnetic current to create a time varying... Agent: Ladas & Parry LLP

20080044891 - Biomass conversion to alcohol using ultrasonic energy: A method comprising applying ultrasonic energy to a biomass to alcohol production process is provided. In one embodiment the alcohol production process is an ethanol production process. In one embodiment, the biomass to alcohol process employs ultrasonic energy as the only means of pretreatment. In one embodiment, the biomass to... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20080044892 - Air pollutants reduction system: Disclosed herein is a method for the air pollutants reduction system. The method comprises the reduction of air pollutants from their generated source, and biologically converting them into other forms of hydrocarbon materials and oxygen with the disclosed process.... Agent: Arthur C. Wu

20080044893 - Multiwell droplet actuator, system and method: Multiwell droplet actuators, systems and methods are provided. According to one embodiment, a substrate is provided and comprises: (a) one or more input ports for introduction of one or more reagents and/or samples; (b) a regular array of processing wells; and (c) a network of droplet transport pathways comprising pathways... Agent: Ward And Smith, P.A.

20080044894 - Cellular culture chip device: A cellular culture chip device includes a chip body. The chip body includes: a first flow channel having a first inlet end and a first outlet end and adapted to direct a liquid nutrient; a second flow channel adapted to direct a gellable culture medium; a medium retaining hole fluidly... Agent: Birch Stewart Kolasch & Birch

20080044895 - Filter support for use with a tissue cassette for collecting and embedding cells: A filter support is releasably connectable to a tissue cassette for collecting and embedding cells in paraffin wax. The cassette includes a cylindrical port which extends from a top surface through a bottom surface of the cassette. The filter support has a cylindrical extension to extend over a bottom end... Agent: Heslin Rothenberg Farley & Mesiti PC

20080044897 - Gene silencing vector and gene silencing method using the same: A gene silencing vector according to the present invention comprises a vector which includes a promoter, an enhancer sequence in the downstream of the promoter, and a gene encoding a potyvirus-origin coat protein in the downstream of the enhancer sequence, wherein in order to cause gene silencing of the specific... Agent: Birch Stewart Kolasch & Birch

20080044896 - Novel human secreted proteins and polynucleotides encoding the same: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.... Agent: Lexicon Pharmaceuticals, Inc.

20080044898 - Promoter, promoter control elements, and combinations, and uses thereof: The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels.... Agent: Birch Stewart Kolasch & Birch

20080044899 - Differentiated cells originating in precursor fat cells and method of acquiring the same: A method wherein differentiation of precursor fat cell lines originating in swine and mouse matured fat cells is induced so as to give cells having other functions; and cells having other functions acquired by this method. By inducing differentiation of precursor fat cell lines originating in swine and mouse matured... Agent: Young & Thompson

20080044900 - Scaffolds for cell transplantation: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release... Agent: Ingrid A. Beattie, Ph.d., J.d. Mintz, Levin, Cohn, Ferris,

20080044901 - Method of inducing the differentiation of embryonic stem cells into nerve by serum-free suspension culture: The present invention provides a clinically applicable method of inducing differentiation of embryonic stem cells, particularly a method of inducing differentiation of embryonic stem cells into forebrain neurons. More specifically, the present invention provides a method of inducing differentiation of embryonic stem cells, comprising culturing the embryonic stem cells as... Agent: Leydig Voit & Mayer, Ltd

20080044902 - Blood brain barrier device: Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.... Agent: Searete LLC Clarence T. Tegreene

20080044903 - Gene transfer methods: Improved methods for transferring a gene into target cells by using a retrovirus, wherein the gene transfer efficiency is improved and the target cells are efficiently transformed by binding the retrovirus to a functional substance which is immobilized on as carrier and having an activity of binding to retroviruses followed... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080044904 - Glyphosate n-acetyltransferase (gat) confers glyphosate resistance when expressed in plastids: Constructs for the expression of glyphosate N-acetyltransferase in plastids and conferring glyphosate resistance are disclosed.... Agent: Dann, Dorfman, Herrell & Skillman

20080044905 - Promoters functional in plant plastids: The present invention relates to isolated nucleic acid molecule comprising the untranslated region of SEQ ID NO: 1, 2 or 3. The invention also relates to chimeric genes comprising SEQ ID NO: 2 operatively linked to the coding sequence of a gene of interest and to plant transformation vectors comprising... Agent: Syngenta Biotechnology, Inc. Patent Department

20080044906 - Modified gene-silencing nucleic acid molecules and uses thereof: Methods and means for efficiently downregulating the expression of a target gene of interest in cell from an organism that is an animal, fungus and protist. The invention provides chimeric nucleic acid molecules for downregulating target genes. The invention also provides modified cells and organisms comprising the chimeric nucleic acid... Agent: Cooper & Dunham, LLP

20080044907 - Modified cry3a toxins and nucleic acid sequences coding therefor: Methods for making a modified Cry3A toxin are disclosed. Such methods include the insertion of a protease recognition site that is recognized by a gut protease of a target insect, such as corn rootworm, into at least one position of a Cry3A toxin so that a modified Cry3A toxin is... Agent: Syngenta Biotechnology, Inc. Patent Department

20080038711 - Method of using differential measurement in two or more channels to improve sensitivity: A method to calibrate measurements of a test analyte in a test sample including measuring at least one test-light level responsive to reactions of at least one reagent group and at least one reactive test analyte in the test sample and measuring at least one control-light level responsive to reactions... Agent: Kathy Manke Avago Technologies Limited

20080038712 - Oligomer probe array with improved signal-to-noise ratio and detection sensitivity and method of manufacturing the same: An oligomer probe array with improved signal-to-noise ratio and desired detection sensitivity ever when a reduced design rule is employed includes a substrate, a plurality of probe cell active regions formed on or in the substrate, each of the plurality of probe cell active regions having a three-dimensional surface and... Agent: F. Chau & Associates, LLC

20080038715 - Method of combing an elongated molecule: Elongated molecules are stretched across a substrate by controlled fluid flow.... Agent: Searete LLC

20080038726 - Compositions and methods for detecting atopobium vaginae: Disclosed are oligonucleotides useful in methods for determining whether a sample contains Atopobium vaginae or has an increased likelihood of containing Atopobium vaginae, an organism which is seen in conjunction with bacterial vaginosis or is a causative agent of bacterial vaginosis. These oligonucleotides, which have nucleotide sequences derived from a... Agent: Medical Diagnostic Laboratories LLC

20080038718 - Method for parallelly sequencing a nucleic acid mixture by using a continuous flow system: s

20080038746 - Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders: The invention presents methods of using splice variants and reagents thereof for diagnosing and monitoring the status of transplants and immune disorders including diagnosing, monitoring and predicting transplant rejection or non-rejection, steroid responsiveness, and onset or flare of immune disorders.... Agent: Morrison & Foerster LLP

20080038725 - Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations: Methods of detecting multiple nucleic acid targets in single cells through indirect capture of labels to the nucleic acids are provided. Methods of assaying the relative levels of nucleic acid targets through normalization to levels of reference nucleic acids are also provided. Methods of detecting individual cells, particularly rare cells... Agent: Quine Intellectual Property Law Group, P.C.

20080038719 - Nucleic acid composite materials made sensors for the analysis of nucleic acid modifying factors: The present invention relates to a method for fabricating a nucleic acid composite material, and to a sensor fabricated with this composite material. This composite material sensor can be used as the working electrode in a conventional electrochemical system, for the measurement of any nucleic acid modifying factors. Protective and/or... Agent: Knobbe Martens Olson & Bear LLP

20080038732 - Oligomer probe array and method of producing the same: An oligomer probe array having improved reaction yield is provided. The oligomer probe array includes a substrate, an immobilization layer on the substrate, a plurality of nano particles coupled with a surface of the immobilization layer, and a plurality of oligomer probes coupled with surfaces of the nano particles.... Agent: Frank Chau, Esq. F. Chau & Associates, LLC

20080038748 - Antibodies that recognize cutting edge within the tgf-beta activation controlling region: It is an object of the present invention to provide antibodies capable of detecting an active TGF-β generation reaction that is specific to pathogenesis, tissues, or isoforms. The present invention provides antibodies against an LAP fragment (or latent TGF-β) generated as a result of generation of active form of human... Agent: Greenblum & Bernstein, P.L.C

20080038752 - Reagents for the detection of protein phosphorylation in c-src signaling pathways: The invention discloses 102 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of c-Src kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose.... Agent: Simona Levi-minzi, Ph.d. General Counsel

20080038758 - Diagnostic method for paratuberculosis: The present invention is intended to provide a diagnostic method for paratuberculosis by which an animal infected with Mycobacterium avium subsp. Paratuberculosis can be diagnosed at a high sensitivity in the sub-clinical infection stage before the specific antibody level begins to increase and a large number of specimens can be... Agent: Antonelli, Terry, Stout & Kraus, LLP

20080038759 - Test strip for lateral flow assays: A test strip configured for the detection of an analyte in a fluid sample and methods for manufacturing and for using the same. The test strip comprises a first flow matrix and a second flow matrix sequentially arranged to form an interface therebetween. The first flow matrix comprises a detection... Agent: Merchant & Gould PC

20080038762 - Method for analyzing blood for lipoprotein components: A new lipoprotein analysis procedure based on the CDC gold standard, analytical ultra centrifugation, having dramatically reduced the time and cost to obtain a result with a self generating continuous gradient. The method allows quantification of the risk factors of cardiovascular disease based on particle numbers of the particles of... Agent: Fulbright & Jaworski, LLP

20080038763 - Method for analyzing blood for lipoprotein components: A new lipoprotein analysis procedure based on the CDC gold standard, analytical ultra centrifugation, having dramatically reduced the time and cost to obtain a result with a self generating continuous gradient. The method allows quantification of the risk factors of cardiovascular disease based on particle numbers of the particles of... Agent: Fulbright & Jaworski, LLP

20080038766 - Dry format sialidase assay: A solid-phase test device and method for the detection of sialidase activity in a fluid sample. The test device comprises a solid support provided with pre-deposited dry form of a sialidase detecting composition comprising a sialidase substrate and a color-developing reagent, wherein the sialidase substrate when exposed to sialidase yields... Agent: Merchant & Gould PC

20080038768 - Assay for ubiquitin mediated proteolysis: The present invention provides methods and compositions useful in the screening for agents that modulate activity of a deubiquitinating enzyme. In one embodiment, the invention relates to methods for measuring a deubiquitination activity comprising combining a deubiquitinating enzyme (DUB) with a substrate comprising a ubiquitin moiety and a fluorescently labeled... Agent: Novartis Corporate Intellectual Property

20080038769 - Method and device for detecting the formation and development of biofilms in a culture medium: A process allowing measuring of viscosity of a culture medium of microorganisms including a) immersing at least one particle that is charged electrically, is magnetic or can be magnetized or covered with at least one magnetic or magnetizable layer in the culture, b) subjecting the culture to an electrical, magnetic... Agent: Ip Group Of Dla Piper US LLP

20080038770 - Cancer stem cells and uses thereof: Disclosed are enriched preparations of neuroblastoma tumor initiating cells (NB TICs). The NB TICs are capable of self-renewal, initiating neuroblastoma tumor growth in vivo and are capable of being passaged in high frequency. These NB TICs have chromosomal abnormalities and are capable of giving rise to secondary tumor spheres. Methods... Agent: Jagtiani + Guttag

20080038775 - Method of synthesizing and purifying dkk proteins and dkk proteins obtained thereby: The invention relates to a novel method of inexpensively synthesizing large quantities of an essentially pure, biologically active, glycosylated Dkk protein, including mammalian and human Dkk proteins (e.g., human Dkk1). The invention further relates to the synthetically produced essentially purified, glycosylated and biologically active Dkk protein, and the characteristics of... Agent: Drinker Biddle & Reath (dc)

20080038778 - Breeding method for yeast, yeast and a production method for glycoprotein or beta-glucan: A method for breeding yeast having thermotolerance or recovering growth activity and a method for breeding yeast which produces beta-glucan efficiently as well as an yeast obtained by such methods for breeding are presented by a method for breeding yeast having thermotolerance or recovering growth activity including a step for... Agent: Osha Liang L.L.P.

20080038710 - Assemblies incorporating biomolecules and/or cells with micro-/nanostructures, and methods of making the same for biological applications: Assemblies incorporating cells, biologically active molecules, or combinations thereof. Three dimensional tissue scaffolds are used in the assemblies. The three dimensional tissue scaffolds include a plurality of scaffold layers seeded with cells, biologically active molecules, or combinations thereof, the plurality of cell scaffold layers stacked one on top of another... Agent: Dinsmore & Shohl LLP

20080038714 - Instrument to pneumatically control lab cards and method thereof: The present invention generally relates to microfluidic devices for carrying out and controlling chemical reactions and analysis. In particular, the present invention provides systems, methods, and devices for controlling lab cards.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20080038713 - System and method for biological assay: The present invention generally relates to microfluidic devices for carrying out and controlling chemical reactions and analysis. In particular, the present invention provides systems, method, and devices related to lab cards.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20080038716 - Cell lines with latent immunodeficiency virus and methods of use thereof: The present invention provides isolated cells that comprise, integrated into the genome of the cell, a transcription-competent immunodeficiency virus or a transcription-competent immunodeficiency virus-based retroviral vector. Under basal in vitro culture conditions, the immunodeficiency virus is latent, and the expression of the latent immunodeficiency virus can be reactivated. The invention... Agent: Bozicevic, Field & Francis LLP

20080038717 - Enrichment method for variant proteins with altered binding properties: A method for selecting novel proteins such as growth hormone and antibody fragment variants having altered binding properties for their respective receptor molecules is provided. The method comprises fusing a gene encoding a protein of interest to the carboxy terminal domain of the gene III coat protein of the filamentous... Agent: Genentech, Inc.

20080038720 - Biologically-active dna-binding sites and related methods: The invention relates to the identification of biologically-active DNA-binding sites to which a protein of interest binds in a cell. The invention also relates to the identification of agents and conditions which alter the biologically-active DNA-binding sites to which a protein binds. One aspect of the invention also provides methods... Agent: Bozicevic, Field & Francis LLP (whitehead Institute Of Biomedical Research)

20080038734 - Compositions and methods for the detection of a nucleic acid using a cleavage reaction: The invention relates to compositions and methods for generating a signal indicative of the presence of a target nucleic acid in a sample utilizing a primer-probe duplex.... Agent: Agilent Techologies Inc

20080038738 - Detecting tumor biomarker in oral cancer: Methods and device for detecting the presence of tumor biomarkers in oral squamous cell carcinoma. A membrane based cell capture device allows deliver of cell samples and reagents to the membrane... Agent: Fulbright & Jaworski L.L.P.

20080038743 - Detection of extracellular tumor-associated nucleic acid in blood plasma or serum: This invention relates to detection of specific extracellular DNA in plasma or serum fractions of human or animal blood associated with neoplastic, pre-malignant or proliferative disease. Specifically, the invention relates to detection tumor-associated DNA, and to those methods of detecting and monitoring tumor-associated DNA found in the plasma or serum... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080038740 - Device and method for extraction and analysis of nucleic acids from biological samples: Device and methods for extracting and analyzing nucleic acids from biological samples.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20080038730 - Diagnostic and therapeutic use of kcnj6 for alzheimer's disease: The present invention discloses a dysregulation of the KCNJ6 gene and the protein products thereof in Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing and prognosticating Alzheimer's disease in a subject, and for determining whether a subject is at increased risk of developing Alzheimer's... Agent: Venable LLP

20080038731 - Diagnostics and therapeutic uses of topors: The present invention relates to topors and its association with cancer. Topors antibodies are provided for use in diagnosing cancer based upon the absence of topors in a given cell or tissue sample. The detection of topors nucleic acid molecules in the diagnosis of cancer is also provided.... Agent: Licata & Tyrrell P.C.

20080038723 - Functional assessment of dna mismatch repair gene variants: Methods and materials are described for determining the susceptibility of an individual to diseases associated with defects in DNA mismatch repair function, principally human colorectal and other cancers, by the use of activity assays to assess the functional significance of mutations in genes encoding DNA mismatch repair proteins. These methods... Agent: Richard J. Mazza C/o Bittech, Inc.

20080038742 - Genetic polymorphisms associated with body fat: In the present invention, cDNA microarrays to investigate pituitary gene expression in two chicken lines that were selected for low and high body fat (Lean and Fat). Differentially expressed genes between lines are potential candidates as genetic markers for high and low potential for body fat accumulation. The lysophosphatidic acid... Agent: Jacobson Holman PLLC

20080038744 - Genetic polymorphisms in the prostate-specific antigen gene promoter: The present invention includes methods of identifying a subject at risk for increased cellular PSA production and/or prostate cancer by detecting the presence or absence of a genetic polymorphism in the prostate specific antigen gene.... Agent: Myers Bigel Sibley & Sajovec

20080038739 - Identification of bitter ligands that specifically activate human t2r receptors and related assays for identifying human bitter taste modulators: The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds. Also, the invention relates to the discovery of specific hT2R9 alleles and their disparate activity in functional assays with the same biter ligands. The invention further relates... Agent: Hunton & Williams LLP Intellectual Property Department

20080038747 - Method for detecting reaction of protein and sample: There is provided a method for detecting a reaction of a fluorescently labeled protein and a sample simply, in a short time and at a higher precision. By using an expression system such as an extracellular gene expression system and an extracellular transcription or translation system, a reaction of expressing... Agent: Scully Scott Murphy & Presser, PC

20080038729 - Method for monitoring the progress of cancer: The present invention relates generally to a method of diagnosing, predicting or monitoring the development or progress of a cancer and, in particular, to a method of diagnosing, predicting or monitoring the development of or progress of prostate cancer in a mammal. The present invention more specifically provides a method... Agent: Scully, Scott, Murphy & Presser, P.C.

20080038722 - Method of diagnosis of a predisposition to develop thrombotic disease and its uses: The present invention refers to a method of diagnosis of a predisposition to develop thrombotic disease, to test systems and their use for the diagnosis of a predisposition to develop thrombotic disease, to a P2X1 promoter variant and its use for screening for an anti-thrombotic agent, and to methods for... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080038737 - Methods and apparatus for sequential amplification reactions: The invention provides methods and apparatus for carrying out multiple amplification reactions in a single reaction chamber by successive cycles of loading reaction mixture, amplifying, and removing spent reaction mixture in a fluidly closed reaction system. In particular, the present invention allows amplification of a plurality of target polynucleotides from... Agent: Townsend And Townsend And Crew, LLP

20080038736 - Methods and compositions for the diagnosis for early hepatocellular carcinoma: Methods and compositions are provide to allow discrimination of dysplastic nodules from early HCC nodules. More specifically, it has been determined that TERT, GPC3, gankyrin, survivin, TOP2A, LYVE1, Ecadherin, IGFBP3, PDGFRA, TGFA, cyclin D1 and HGF are differentially expressed in HCC as compared to normal liver cells and liver cells... Agent: Marshall, Gerstein & Borun LLP

20080038724 - Methods for amplifying polymeric nucleic acids: The invention provides compositions and methods for amplifying nucleic acid polymer sequences in a high complexity nucleic acid sample. The unique compositions of the invention include a primer set composed of a mixture of two types of primers for DNA synthesis. For extension in one direction, the primers all contain... Agent: Integrated Dna Technologies, Inc. C/o Darby & Darby P.C.

20080038727 - Microrna and messenger rna detection on arrays: The present teachings provide methods for reverse transcribing, and detecting, a plurality of small nucleic acids such as micro RNAs, from the same reaction mixture as a plurality of messenger RNAs. High levels of multiplexing are provided by the use of a plurality of zip-coded stem-loop reverse transcription primers, along... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20080038745 - Nucleotide analogs with six-membered rings: The present invention is related to compounds comprising six-membered rings capable of being incorporated into nucleic acids. Particularly, the six-membered ring is a derivative of cyclohexane, cyclohexene, tetrahydropyran, tetrahydrothiopyran or piperidine. These compounds may be used to build up oligomeric compounds. The invention is further related to uses of these... Agent: Marilyn L. Amick Roche Diagnostics Operations, Inc.

20080038728 - Quadruple transformed cell line useful for the identification of transport inhibitors: Described is a cell line containing (a) three DNA sequences encoding different uptake transporters for organic anions, preferably OATP1B1, OATP1B3 and OATP2B1, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively... Agent: Moore & Van Allen PLLC

20080038733 - Screening for down syndrome: The present disclosure describes methods for screening and identifying genomic sequences useful in estimating the risk of fetal aneuploidy, particularly trisomy 21. This disclosure also describes methods for utilizing such genomic sequences alone or to augment existing non-invasive diagnostics for Trisomy 21 and other aneuploidies.... Agent: Fulbright & Jaworski, LLP

20080038721 - Sequence capable of accelerating gene expression at moderately low temperature: wherein x1 represents t, g, or a; x6 represents g, a, or c; x7 represents c, a or t; x8 represents c, a or t, or a nucleotide sequence complementary to the nucleotide sequence is used as an enhancer and mammalian cells are cultivated at a mild low temperature, the... Agent: Birch Stewart Kolasch & Birch

20080038741 - T1r taste receptors and genes encoding same: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department

20080038735 - Tus dna binding domains: The present invention relates to a nucleic sequence encoding one or more Tus DNA binding domains, one or more DNA binding sites and at least one polypeptide domain.... Agent: Edwards Angell Palmer & Dodge LLP

20080038749 - Biosensor and method for operating the latter: A biosensor for detecting an antigen using an antigen/antibody coupling includes: a silicon substrate, at least one interdigital electrode pair structure that is located on the silicon substrate, the electrode pair being interspaced at a maximum distance of 1.0 μm; a counter-electrode on the silicon substrate; a reference electrode; a... Agent: Young & Thompson

20080038751 - Methods for determining conformational changes and self-assembly of proteins: The invention relates to methods for measuring conformational changes and self-assembly/aggregation of proteins, especially the formation of amyloid fibrils, using conjugated polyelectrolytes. The conjugate polyelectrolyte is exposed to the protein whereby the conjugated polyelectrolyte and the protein of interest interact, and a change of a property of the polyelectrolyte in... Agent: Young & Thompson

20080038750 - Multivalent chelators for modifying and organizing of target molecules: e

20080038754 - Biomarkers for early detection of ovarian cancer: Three panels of biomarker proteins that can be used in the diagnosis of early-stage ovarian cancer (OC) are described. The biomarker panels not only permit the distinction of patients with ovarian neoplasia (benign or malignant) from normal subjects, but they also allow the identification of patients with early-stage (stage I/II)... Agent: Karen S. Canady Canady & Lortz LLP

20080038755 - Cellspot applications: A multiplicity of applications of the CellSpot™ assay method are described. Among these applications are extension to integral membrane protein probes, extension to secretion from bacterial cells, identification of antibodies with enhanced affinity, identification of clones with increased secretion levels, and use of massively parallel screening to identify rare efficacious... Agent: Morrison & Foerster LLP

20080038756 - Fret protease assays for clostridial toxins: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum... Agent: Allergan, Inc.

20080038757 - Method for rapidly and conveniently detecting target substances and enzyme immunological kit therefor: A measurement kit capable of rapidly and conveniently detecting one type or a plurality of types of target substance(s) simultaneously in a sample and a measurement method therefor are provided. Furthermore, with the kit or the measurement method, disease with which a target substance is associated is diagnosed. The enzyme... Agent: Birch Stewart Kolasch & Birch

20080038753 - Pharmaceutical manufacturing methods: The invention describes methods for manufacturing oligoadenylate synthetase (OAS) proteins for use as active pharmaceutical ingredients in pharmaceutical compositions. A manufacturing method is described that produces large quantities of concentrated, highly active OAS protein for use in pharmaceutical compositions for the treatment of a variety of diseases including viral infection.... Agent: Davis Wright Tremaine, LLP/seattle

20080038761 - Compositions and methods for detecting and quantifying toxic substances in disease states: The present invention relates to compositions comprising synthetic aggregated peptides (SAPs). The present invention also relates to the use of these SAPs as standards in methods for quantifying substances in a sample. The present invention also relates to methods of detecting, diagnosing and monitoring the progression of an abnormal condition... Agent: Invitrogen Corporation C/o Intellevate

20080038760 - Method for detecting anti-transglutaminase antibodies: Methods for detecting anti-transglutaminase antibodies in a saliva sample containing the antibodies are disclosed. Saliva samples are pre-treated. The antibodies are subsequently detected in the pre-treated saliva by an immune reaction with a transglutaminase under conditions suitable for forming immuno-complexes with the antibodies. The method is useful for diagnosing and/or... Agent: Knobbe Martens Olson & Bear LLP

20080038764 - Compositions, kit and one-step method for monitoring compounds having anti-factor xa and/or anti factor iia activities: Provided are compositions and methods for accurate determination of the concentration of anticoagulant in a sample such as a blood or plasma sample. The compositions can contain a Factor X compound and Factor V compound, and additional components as well. Methods for performing the assay include one-step methods in which... Agent: Knobbe Martens Olson & Bear LLP

20080038765 - Composition for lipase activity determination and method of determing activity: [PROBLEMS] To provide lipase activity determination reagents which function by an enzymatic method. The reagents are easy to use in an ordinary clinical examination, have excellent handleability, and are excellent in accuracy and reproducibility. [MEANS FOR SOLVING PROBLEMS] Lipase activity is determined with any of reagents which comprise a low-concentration... Agent: Greenblum & Bernstein, P.L.C

20080038767 - Method for accessing microbial diversity: A method of interfering with quorum sensing regulation of genes to promote cell growth is disclosed. The method of is aimed at accessing microbial biodiversity. The method involves obtaining an environmental sample comprising at least one novel (uncultivated in the laboratory) microorganism, contacting the environmental sample with an effective amount... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20080038772 - Composition, method and kit for reducing background staining: Compositions, methods and kits are disclosed for improved staining of a cell or tissue with a dye-conjugate that binds specifically to a particular component of the cell or tissue. The compositions, methods and kits include a polymeric material that reduces non-specific binding of a dye-conjugate to components of the cell... Agent: Invitrogen Corporation C/o Intellevate

20080038773 - Composition, method and kit for reducing background staining: Compositions, methods and kits are disclosed for improved staining of a cell or tissue with a dye-conjugate that binds specifically to a particular component of the cell or tissue. The compositions, methods and kits include a polymeric material that reduces non-specific binding of a dye-conjugate to components of the cell... Agent: Invitrogen Corporation C/o Intellevate

20080038771 - Quantifiable internal reference standards for immunohistochemistry and uses thereof: Methods for identifying Quantifiable Internal Reference Standards (QIRS) for immunohistochemistry (IHC). Also disclosed are methods for using QIRS to quantify test antigens in IHC.... Agent: Hogan & Hartson L.L.P.

20080038774 - Process for producing astaxanthin-containing lipids: In order to attain this object, the green alga Haematococcus pluvialis is cultured with an organic nitrogen source being used in a medium at an AN/TN ratio of 65% or less, preferably 43% or less, more preferably 35% or less, to obtain algal bodies in which astaxanthin-containing lipids have been... Agent: Drinker Biddle & Reath (dc)

20080038776 - Method for preparing a macromolecule of bacterial origin, macromolecule thus obtained, and use of the said molecule in the prevention and treatment of inflammatory rheumatic disease: The present invention relates to a method for the preparation of a macromolecule produced by bacteria of the Bifidobacterium breve I-2219 strain and the use of the said macromolecule for the preparation of medicines designed for the prevention and treatment of inflammatory rheumatic disease.... Agent: Mcleland Patent Law Office, P.l.l.c.

20080038777 - Synthetic dog/human chimeric c-c chemokine receptor 2b: Disclosed herein are polynucleotides encoding a chimeric C—C chemokine receptor 2B, the encoded polypeptides thereof, and methods of making and using said polynucleotides and polypeptides.... Agent: Potter Anderson & Corroon LLP/wyeth

20080038779 - Manufacture of five-carbon sugars and sugar alcohols: The invention relates to the methods of manufacturing five-carbon sugars and sugar alcohols as well as other compounds derived from pentose-phosphate pathway from readily available substrates such a hexoses using metabolically engineered microbial hosts.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080038780 - Production of low molecular weight hyaluronic acid: (b) then cultivating the recombinant Bacillus host cell of step (a) at a second temperature higher than the first temperature of step (a) under conditions suitable for production of the hyaluronic acid, whereby the Bacillus host cell produces hyaluronic acid with a desired average molecular weight in the range of... Agent: Novozymes North America, Inc.

20080038781 - Method for producing purine nucleoside by fermentation: A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated repressor of purine nucleotide biosynthesis encoded by purR, a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080038783 - Compositions and methods pertaining to guanylation of pna oligomers: This invention is related to compositions and methods pertaining to PNA oligomers comprising one or more guanidinium moieties.... Agent: Applied Biosystems

20080038782 - Reaction buffer composition for nucleic acid replication with packed dna polymerases: The invention relates to compositions, methods, and kits for nucleic acid replication, including polymerase chain reaction (PCR) and mutagenesis reactions. A buffer composition is provided which allows higher concentrations of DNA polymerase to be used, resulting in greater yield of amplified product and faster reaction kinetics.... Agent: Agilent Techologies Inc

20080038784 - Method of converting a biomass into biobased products: The present invention provides a method of converting a biomass into biobased products. An impact process of accelerating and decelerating the biomass is engaged to fractionate the biomass. As the biomass is fractionated, it is also classified by each resulting biomass fraction. The biomass fraction is then processed into a... Agent: Greenberg Traurig, LLP

20080038785 - Processes for preparing optically active (s or r-)-beta-amino acid and optically active (r or s)-beta-amino acid ester, and beta-amino acid 2-alkoxyethyl ester and optically active (s or r)-beta amino acid 2-alkoxyethyl ester: e

20080038786 - Method of producing substance: The present invention provides a microorganism belonging to the genus Escherichia in which the activities of glutamine-synthetase adenylyltransferase (GlnE protein) and PII regulatory protein for glutamine synthetase are reduced or lost and which has the ability to form and accumulate L-glutamine or a substance biosynthesized utilizing nitrogen supplied by L-glutamine,... Agent: Nixon & Vanderhye, PC

20080038787 - Methods for the preparation of a fine chemical by fermentation: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i. e., glycerol kinase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by... Agent: Lahive & Cockfield, LLP

20080038788 - Process for preparing monomers and polymers thereof: A process of preparing an ethylenically unsaturated amide or an ethylenically unsaturated carboxylic acid or salt thereof from the corresponding ethylenically unsaturated nitrile wherein the nitrile is subjected to a hydration or hydrolysis reaction in an aqueous medium in the presence of a biocatalyst, wherein the nitrite contains above 2... Agent: Ciba Specialty Chemicals Corporation Patent Department

20080038789 - Method for polyunsaturated fatty acid production using novel cell preservation technique: A method for preservation of a microorganism capable of microbial production of a polyunsaturated fatty acid or a compound comprising a polyunsaturated fatty acid as a constituent fatty acid, which method comprises: (a) forming spores in a spore-forming medium at pH 4-7 containing a nutrient source comprising an inorganic salt... Agent: Drinker Biddle & Reath (dc)

20080038790 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS... Agent: Sheridan Ross PC

20080038791 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS... Agent: Sheridan Ross PC

20080038792 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS... Agent: Sheridan Ross PC

20080038793 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross PC

20080038794 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross PC

20080038795 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross PC

20080038796 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross PC

20080038797 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using... Agent: Sheridan Ross PC

20080038798 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross PC

20080038799 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross PC

20080038800 - Solventless extraction process: The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing water soluble compound and/or materials by washing the lysed cell mixtures with aqueous... Agent: Sheridan Ross PC

20080038801 - Gene-substituted microorganisms, and production method of polyesters using the same: e

20080038802 - Method of making optically active ester derivatives and their acids from racemic esters: The present invention relates to process for the preparing of optically active ester derivatives and their acid derivatives which are used intensively as important chiral intermediates from racemic β-hydroxybutyl ester derivatives. In more detail, this invention relates to the process for preparing optically active β-hydroxybutyl ester derivatives and their acid... Agent: John W Renner Renner Otto Boisselle Sklar LLP

20080038803 - Process for producing optically active secondary alcohol: The present invention provides a method enabling convenient production of an optically active secondary alcohol useful as a pharmaceutical intermediate, particularly an optically active 1,2-diol and an optically active 2-alkanol, from an enantiomer mixture thereof. An oxidizing enzyme source having the capability of selectively oxidizing one enantiomer of secondary alcohol... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080038804 - A process for producing biodiesel from renewable oil under lipase catalysis in an organic medium reaction system: The present invention provides a new process for producing biodiesel from renewable oil under lipase catalysis in an organic medium reaction system. In this process, a short chain alcohol ROH is used as an acyl acceptor, a relatively hydrophilic organic solvent having no negative effect on the reactivity of lipase... Agent: Gottlieb Rackman & Reisman PC

20080038805 - Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria: The present invention provides methods and compositions for producing isoprene hydrocarbons from microalgae, cyanobacteria, and photosynthetic and non-photosynthetic bacteria.... Agent: Townsend And Townsend And Crew, LLP

20080038806 - Magnetic manipulation of biological samples: The invention relates to a cell carrier (10) for receiving a biological sample. Said carrier comprises a magnetic element (20) and a floor element (30) that forms a stable support (31) that can be displaced on a solid base surface in at least one direction. The invention also relates to... Agent: Pearl Cohen Zedek Latzer, LLP

20080038807 - Technical process and plant for extraction and/or encapsulation of living cells from organs: The invention relates to a method and a corresponding plant for the extraction and/or encapsulation of living cells from organs. In a first step, the organ containing the cells is disintegrated in an enzymatic process into individual cells or cell agglomerations. The relevant cells are then isolated from the obtained... Agent: Bodner & O'rourke, LLP

20080038808 - Method to bind enzyme to carrier using cationic copolymers and product produced thereby: Disclosed are a method of adhering active enzymes to an inert support, the product produced thereby, and a method of using the enzyme-coated support in enzyme-catalyzed reactions such as the glucose isomerase-catalyzed conversion of glucose to fructose. The method includes the steps of coating an inert support with a cationic... Agent: Janet K. Castaneda Genencor International, Inc.

20080038809 - Isolated lectin polypeptides consisting of truncated mammalian udp-galnac:polypeptide n- acetylgalactosaminyltransferases: Novel methods for identification of inhibitors or modulators of binding activities mediated by lectin domains of polypeptide GalNAc-transferases are disclosed. Direct binding activity of GalNAc-transferase lectins has been demonstrated for the first time and methods to measure lectin mediated binding of isolated lectins or enzymes with lectin domains are disclosed.... Agent: Darby & Darby P.C.

20080038810 - Droplet-based nucleic acid amplification device, system, and method: The present invention relates to a droplet-based nucleic acid amplification device, system, and method. According to one embodiment, a droplet microactuator is provided and includes: (a) a substrate comprising electrodes for conducting droplet operations; and (b) one or more temperature control means arranged in proximity with one or more of... Agent: Ward And Smith, P.A.

20080038811 - Organ preservation apparatus and methods: This invention is a transportable organ preservation system that substantially increases the time during which the organ can be maintained viable for successful implantation into a human recipient. A chilled oxygenated nutrient solution is pumped through the vascular bed of the organ after excision of the organ from the donor... Agent: Mcandrews, Held & Malloy, Ltd.

20080038812 - Systems for screening pharmaceutical chemicals: An apparatus for culturing a bio-artificial tissue including a multi-well plate and a scaffold is disclosed herein. Also disclosed is a tissue indentation system that includes a probe, an isometric force transducer, a computer and a computer-controlled motor. A tissue response system is provided and has a well including a... Agent: Michael Best & Friedrich LLP

20080038813 - Sample vessels: A device for processing a biological sample includes a processing unit having at least one opening to receive a sample vessel and a plurality of processing stations positioned along the opening. The processing stations each have a compression member adapted to compress the sample vessel within the opening and thereby... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20080038814 - Nanotube mat with an array of conduits for biological cells: A nanotube mat containing one or more hydrogels is provided. The nanotube mat/hydrogel device allows for the formation of conduits partially or completely through the thickness of the device. The device could be used as support or host device for biological cells, an agent delivery device or a prosthetic interface.... Agent: Lumen Intellectual Property Services, Inc.

20080038815 - Method and system for the large scale collection, preparation, handling and refining of ligno-cellulosic biomass: A system for collecting ligno-cellulosic biomass over a large area to enable the commercial refining of biomass from 2,500 to in excess of 50,000 tons of biomass per day to produce ethanol or other products. The biomass is collected at a series of collection points and then transported through a... Agent: Fitzpatrick Cella Harper & Scinto

20080038816 - Novel bioreactor for generating uniform shear stress distribution: The present invention relates to a bioreactor for generating uniform distribution of shear stress, comprising: a cone, having a cone surface with an outline of modified catenary; a container, having a fixed plate at the bottom inside the accommodating space of said container, and said fixed plate comprises a plurality... Agent: Bacon & Thomas, PLLC

20080038817 - Method of harvesting tissue intraoperatively: A method of harvesting tissue intraoperatively is disclosed and can include exposing a joint in a patient. Further, the method can include resecting tissue from the joint and identifying healthy tissue. The method can also include placing the healthy resected tissue in a container with a tissue preservation fluid.... Agent: Larson Newman Abel Polansky & White, LLP

20080038818 - Method for sterilization of biological preparations: The invention provides a method for the sterilization of a biological preparation comprising desired viable biological entities. The method comprises irradiating a dried (e.g. freeze-dried) biological preparation with ionizing or UV radiation at an intensity and for a duration sufficient to reduce the amount or activity of living-matter contaminants in... Agent: Nath & Associates

20080038820 - Induction of pluripotent stem cells into mesodermal lineages: The present invention provides a method of inducing mesoderm derived cells from pluripotent stem cells. In contrast to methods known in the art that are often designed to replicate in vivo events of mesoderm induction, the present invention provides a unique, yet simple, method whereby pluripotent stem cells are mesodermally... Agent: Gehrke & Associates, S.c.

20080038819 - Micro rna inhibiting the expression of wt1 gene and utilization of the same: It was found that miRNA that targets the vicinity of the WT1 gene stop codon not only suppresses the expression of the WT1 gene, but also exhibits a marked effect of suppressing cell growth in cancer cell lines.... Agent: Fish & Richardson PC

20080038821 - Cell-releasing agent and method of releasing cell sheet: A cell-sheet releasing agent of the present invention contains an aminated polyrotaxane. The polyrotaxane constituting the skeleton of the cell-releasing agent of the present invention has a structure in which cavities of a plurality of cyclic molecules are threaded onto a linear molecule and both terminals of the linear molecule... Agent: Oliff & Berridge, PLC

20080038822 - Virus clearance of neoplastic cells from mixed cellular compositions: The present invention relates to a method for removing neoplastic cells from a mixed cellular composition, which is outside of a living organism, by using a virus which selectively infect and kill neoplastic cell. A variety of viruses can be used in this method to remove neoplastic cells for different... Agent: Fish & Richardson P.C.

20080038823 - Method of separating pancreatic islet: The present invention provides a pancreatic islet isolation method comprising the steps of (1) injecting a protection solution containing a protease inhibitor into the pancreatic duct of an procured pancreas; (3) digesting the pancreas into which the protection solution has been injected; and (4) purifying the digested pancreatic tissue using... Agent: Fitch, Even, Tabin & Flannery

20080038824 - Composition and method for elevating gene transfer efficiency: It is intended to provide a method whereby transfer efficiency can be improved under any conditions in the case of transferring (in particular, transfecting) a target substance that cannot easily be transferred into cells (for example, a DNA, a polypeptide, a sugar, a complex thereof or the like). Namely, a... Agent: Seed Intellectual Property Law Group PLLC

20080038825 - L-amino acid-producing bacterium and method for producing l-amino acid: An L-amino acid is produced by culturing a Methylophilus bacterium which can grow by using methanol as the main carbon source and has L-amino acid-producing ability, for example, a Methylophilus bacterium in which dihydrodipicolinate synthase activity and aspartokinase activity are enhanced by transformation of cells with a DNA coding for... Agent: Cermak & Kenealy LLP Acs LLC

20080032280 - Method and kits for detecting human cytomegalovirus: The present invention provides methods and kits for detecting human cytomegalovirus. The present invention also provides oligonucleotides for detecting human cytomegalovirus.... Agent: Wpat, PC Intellectual Property Attorneys

20080032286 - Competition assay for identifying modulators of quadruplex nucleic acids: Featured herein are competition assays useful for identifying candidate molecules that selectively interact with a nucleic acid having a particular quadruplex structure.... Agent: Morrison & Foerster LLP

20080032288 - Labeling reagents, methods for the synthesis of such reagents and methods for the detection of biological molecules: a

20080032287 - Method for detecting and quantifying rare mutations/polymorphisms: The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The rare mutation can be any type of functional or non-functional nucleic acid change or mutation, such as deletion,... Agent: Ronald I. Eisenstein

20080032290 - Nanopore flow cells: Systems and methods for nanopore flow cells are provided.... Agent: Agilent Technologies Inc.

20080032289 - Novel twik-6, twik-7, ic23927, twik-8, ic47611, ic47615, hnmda-1, twik-9, alpha2delta-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084fl and 67084alt molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated TWIK-6, TWIK-7, IC23927, TWIK-8, IC47611, IC47615, HNMDA-1, TWIK-9, α2δ-4, 8099, 46455, 54414, 53763, 97076, 97102, 44181, 67084FL and 67084alt nucleic acid molecules, which encode novel ion channel family molecules, including calcium channels, potassium channels, and NMDA receptors. The invention also provides antisense... Agent: Millennium Pharmaceuticals, Inc.

20080032285 - Sequences diagnostic for foot and mouth disease: Methods and materials for the detection of the foot and mouth disease virus (FMDV). The methods may utilize PCR amplification, with or without an internal positive control, and appropriate primer pairs. The reagents to perform these methods can be supplied as a kit and/or in tablet form.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080032313 - Cycochrome c synthesis inhibitors: The invention provides methods for identifying a compound that inhibits cytochrome c synthesis. This invention further provides a method for the high throughput screening of compounds that inhibit cytochrome c synthesis.... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080032311 - Low volume mixing of sample: A method for low volume mixing includes suspending particles in a solution having an analyte and agitating or heating the solution. Heating the solution heats the particles suspended in the solution, thereby increasing movement of the particles. The movement of the suspended particles mixes the analyte within the solution.... Agent: Agilent Technologies Inc.

20080032320 - Method of screening compound capable of accelerating or inhibiting apoptosis, apoptosis accelarator and apoptosis inhibitor: A method for screening a pro-apoptotic compound comprising a determination step of determining a compound enhancing interaction between p73 and IKK-α as a pro-apoptotic compound.... Agent: Sughrue Mion, PLLC

20080032321 - System and methods for analyzing images of tissue samples: A system for analyzing tissue samples, comprising: a storage device for at least temporarily storing one or more images of one or more cells, wherein at least one of the images is indicative of one or more channels comprising a receptor tyrosine kinase (RTK); and a processing device that determines... Agent: General Electric Company Global Research

20080032323 - Nucleic acid construct containing a nucleic acid derived from the genome of hepatitis c virus (hcv) of genotype 2a, and a cell having such nucleic acid construct introduced therein: The present invention relates to a replicon RNA comprising a nucleotide sequence at least containing the 5′ untranslated region, the nucleotide sequence encoding NS3 protein, NS4A protein, NS4B protein, NS5A protein and NS5B protein, and the 3′ untranslated region on the genomic RNA of hepatitis C virus of genotype 2a.... Agent: Birch Stewart Kolasch & Birch

20080032326 - Method and apparatus for enhanced detection of toxic agents: A water quality analyzer for real-time detection according to the invention comprises a biased AC electro-osmosis (ACEO) cell for receiving a fluid to be analyzed having a plurality photosynthetic organisms therein, and concentrating the plurality photosynthetic organisms into at least one concentrated region. A photodetector is provided for obtaining a... Agent: Akerman Senterfitt

20080032328 - System and method for co-registering multi-channel images of a tissue micro array: A system and methods for co-registering multi-channel images of a tissue micro array, comprising the steps of, providing a biological material on a substrate; applying one or more molecular probes, adapted to provide fluorescent molecular markers, to the biological material; obtaining a first digital image of the biological material and... Agent: General Electric Company Global Research

20080032330 - Process for self-assembly of structures in a liquid: A process and apparatus for self-assembling a number of elements and determining their sequence is provided. In the field of DNA analysis, an iterative process is disclosed wherein an apparatus with a set of reaction chambers in which a species of recognition element nucleotides are differentially added and subjected to... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20080032332 - Antibodies against the pro1754 polypeptides: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Heller Ehrman LLP

20080032334 - Cytokine protein family: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral... Agent: Zymogenetics, Inc. Intellectual Property Department

20080032333 - Polynucleotides encoding soluble zalpha11 cytokine receptors: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zalpha11 receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding... Agent: Zymogenetics, Inc. Intellectual Property Department

20080032344 - Process for recovery of holocellulose and near-native lignin from biomass: A process is provided for the recovery of holocellulose sugars and a near-native lignin co-product from lignocellulosic biomass. The cellulose produced from the process is amenable to subsequent enzymatic hydrolysis to produce monomeric sugar units which can be combined with hemicelluloses-derived sugar units to be co-fermented to produce biofuels and/or... Agent: Fulbright & Jaworski, LLP

20080032278 - Engineered tubular tissue structures: A method and apparatus and associated components are described for producing a cellular tissue structure including a wall surrounding a space or passage. A suspension of cells is introduced into a culture vessel (70) of elongate tubular form defining an internal tissue formation surface. The vessel is rotated about a... Agent: Young & Thompson

20080032279 - Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions: Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.... Agent: Fish & Richardson P.C.

20080032281 - Method and device for rapid detection and quantitation of macro and micro matrices: The present invention provides a method and device for rapidly detecting the presence of analytes in a sample. Quantitative and qualitative measurements of analyte concentration in a sample may be rapidly obtained. A sample including the analyte and analyte metabolites produced by the analyte are introduced into a vessel that... Agent: Trask Britt

20080032282 - Methods and applications of molecular beacon imaging for infectious disease and cancer detection: Molecular beacon for detecting an infection and/or expression or a mutation of a disease marker for diagnostics and pharmacogenomics. The molecular beacon is capable of hybridizing a disease-related RNA or DNA of a disease marker in a specimen obtained from a living subject, thereby emitting a signal detectable without a... Agent: Morris Manning Martin LLP

20080032284 - Pharmaceutical compositions and utilization thereof particularly for the treatment of neurodegenerative diseases: The present invention relates to pharmaceutical compositions that act on the p53 protein or its gene and methods of use for the treatment of neurodegenerative diseases.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080032283 - Telomelysin/gfp-expressing recombinant virus: The present invention relates to providing a reagent for cancer cell detection or cancer diagnosis, a pharmaceutical composition for the treatment of cancer, and a method of treating or preventing cancer in a subject. Specifically, the present invention relates to a reagent for cancer cell detection, comprising a recombinant virus... Agent: Darby & Darby P.C.

20080032301 - Articles having localized molecules disposed thereon and methods of producing same: Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate. The methods may include optical, chemical and/or mechanical processes for the deposition, removal, activation and/or deactivation of chemical groups in selected... Agent: Quine Intellectual Property Law Group, P.C.

20080032309 - Compostions and methods for identifying transformed cells: The present invention relates to compositions and methods for identifying transformed cells. The method comprises introducing a visual marker polynucleotide into a plant cell and providing a growth stimulation protein. The compositions comprise a visual marker polynucleotide and a growth stimulation polynucleotide. Also provided are expression cassettes, plant cells, plant... Agent: Pioneer Hi-bred International, Inc.

20080032310 - Detection of analytes and nucleic acids: Methods of detecting at least one analyte and at least one nucleic acid in a sample are provided. Reagents for carrying out the methods are also provided.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080032294 - Dna sensor and measuring method using the same: A DNA sensor is provided which is capable of identifying unknown DNA with enhanced detection sensitivity of the hybridization. A p-channel field-effect transistor having an electrolyte solution gate 8 and having as a p-channel 5 a diamond surface 2 which contains a mixture of at least a hydrogen-terminated surface and... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080032304 - Full-length cdna and polypeptides: cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information useful for analyzing the functions of... Agent: Foley And Lardner LLP Suite 500

20080032293 - Housekeeping genes and methods for identifying same: Disclosed are methods compositions and methods related to housekeeping genes and methods and compositions related to detecting and classifying cancer.... Agent: Needle & Rosenberg, P.C.

20080032308 - Isolating, positioning, and sequencing single molecules: Devices and methods for isolating, detecting, and positioning single polymeric molecules without the need for expensive equipment are provided. The disclosed devices and methods allow for a molecule to be quickly and efficiently transported to a specific sub-micron area. Such devices are useful, for instance, for performing analyses in which... Agent: Intel/blakely

20080032300 - Lupac bifunctional marker and its use in protein production: This invention relates to industrial production of proteins. More specifically, the invention relates to the Lupac surrogate marker, which corresponds to a fusion between luciferase and the puromycin N-acetyl transferase. The invention further relates to the use of Lupac for screening cells for high expression of a protein of interest.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080032302 - Method and probe set for detecting cancer: Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset of cells obtained from the biological sample are described. A set of chromosomal probes and kits for detecting cancer... Agent: Fish & Richardson P.C.

20080032291 - Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes: Disclosed is a method for determining haplotypes useful for large-scale genetic analysis, within a genomic reference sequence of interest, for a human subpopulation. The method can applied to statistically evaluating the genotypes of subjects for any statistically significant association with a phenotype of interest, such as insulin resistance or coronary... Agent: Perkins Coie LLP

20080032305 - Methods and compositions for analysis of ugt1a1 alleles: The present invention relates to methods for detecting polymorphisms in enzymes related to drug metabolizm (Drug Metabolizing Enzymes or DMEs) such as uridine diphosphate glucuronosyl transferase (UGT) gene promoter, with nucleic acid detection assays. The present invention also relates to detection assay kits.... Agent: Medlen & Carroll, LLP

20080032306 - Methods and kits for detection of nucleic acid amplification products: The present invention provides methods, products, and kits for detection of target nucleic acids. Detection is based, at least in part, on detection of chromophores that have different chromogenic properties depending on their association with double-stranded nucleic acids. In general, labeled reagents are exposed to denatured nucleic acids, and the... Agent: Agilent Techologies Inc

20080032298 - Methods for assessing efficacy of chemotherapeutic agents: Methods are provided for accurately predicting efficacy of chemotherapeutic agents. Methods of the invention increase the positive predictive value of chemosensitivity assays by assessing both the ability of a chemotherapeutic to destroy cells and the genetic propensity of those cells for resistance. Results obtained using methods of the invention provide... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080032299 - Methods for prognosis and treatment of solid tumors: Solid tumor prognosis genes, and methods, systems and equipment of using these genes for the prognosis and treatment of solid tumors. Prognosis genes for a solid tumor can be identified by the present invention. The expression profiles of these genes in peripheral blood mononuclear cells (PBMCs) are correlated with clinical... Agent: Wyeth Patent Law Group

20080032292 - Methods for the detection of ovarian cancer: Methods and kits for the detection of ovarian cancer are provided.... Agent: Dann, Dorfman, Herrell & Skillman

20080032297 - Methods to increase nucleotide signals by raman scattering: The methods and apparatus disclosed herein concern nucleic acid sequencing by enhanced Raman spectroscopy. In certain embodiments of the invention, nucleotides are covalently attached to Raman labels before incorporation into a nucleic acid. In other embodiments, unlabeled nucleic acids are used. Exonuclease treatment of the nucleic acid results in the... Agent: Intel Corporation C/o Darby & Darby P.C.

20080032296 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross PC

20080032295 - Sensing apparatus and method: Use of a pH sensor comprising an ion-sensitive field effect transistor (ISFET) to perform real time detection/quantification of nucleic acid amplification, e.g. polymerase chain reaction (PCR) nucleic acid amplification, based on detection of protons released during the primer extension phase.... Agent: Synnestvedt & Lechner, LLP

20080032303 - Species identification by melting analysis of secondary structure of single stranded nucleic acids: Methods of identifying the type of a cell are provided, the methods comprising determining the Tm profile of a sample rRNA or fragment thereof from the cell using a double stranded nucleic acid-specific dye, wherein a match between the determined Tm profile and the Tm profile of a corresponding rRNA... Agent: Ice Miller LLP

20080032307 - Use of single-stranded nucleic acid binding proteins in sequencing: The invention provides methods for stabilizing a nucleic acid sequencing reaction. Generally, methods of the invention include exposing a target nucleic acid to a single-stranded nucleic acid binding protein and performing a sequencing reaction.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080032312 - Compositions and methods for measuring analyte concentrations: The current invention relates to fusion proteins comprising at least one functional periplasmic binding protein, at least one labeling moiety and at least one fluorescent protein. In one embodiment, the periplasmic binding protein is a functional glucose-galactose binding protein (GGBP). The invention also relates to methods for quantifying an analyte,... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20080032315 - Method and kit for determining the immunisation status of a person: The present invention concerns a method for determining vaccine status by quantifying type-IgG serum antibodies of a plurality of pathogenic agents, characterized in that the steps are conducted of: 1—contacting one same said serum sample to be tested with one same solid substrate on which a plurality of said vaccine... Agent: Dennison, Schultz & Macdonald

20080032316 - Tumor associated antigens and methods of using the same: The present invention provides methods and compositions for the diagnosis of hyperproliferative disease and autoimmune disease. Tumor associated antigens, nucleic acids encoding them and antibodies to the tumor associated antigens are provided for the diagnosis of hyperproliferative disease, such as, for example, ovarian cancer, breast cancer, lung cancer, colorectal cancer,... Agent: Townsend And Townsend And Crew, LLP

20080032317 - Methods for improving the function of heterlogous g protein-coupled receptors: This invention relates to mutant G protein-coupled receptors with improved G-protein coupling and receptor response, yeast cells expressing such receptors, vectors useful for making such cells, and methods of making and using same.... Agent: Wyeth/finnegan Henderson, LLP

20080032318 - Fret protease assays for clostridial toxins: The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum... Agent: Allergan, Inc.

20080032314 - Use of vegf and homologuest to treat neuron disorders: The present invention relates to neurological and physiological dysfunction associated with neuron disorders. In particular, the invention relates to the involvement of vascular endothelial growth factor (VEGF) and homologues in the aetiology of motor neuron disorders. The invention further concerns a novel, mutant transgenic mouse (VEGFm/m) with a homozygous deletion... Agent: Amster, Rothstein & Ebenstein LLP

20080032319 - Method for diagnosing colon cancer: The present invention relates to a method for diagnosing colon cancer by detecting a colon cancer specific antigen, defensin α6 from the blood of patient and a diagnostic kit for colon cancer comprising anti-defensin α6 antibody. The diagnostic kit for colon cancer of present invention comprises: a solid support such... Agent: Darby & Darby P.C.

20080032322 - Method for incorporation of two oxygen atoms into digested peptides using peptidases: A method for comparative proteomics using a peptidase under enzymatic conditions that permits the optimal incorporation of two oxygen atoms into a digested peptide. The method employs a peptidase to incorporate two 18O atoms into a peptide set derived from a population of proteins at a conditioned state, which is... Agent: Kinney & Lange, P.A.

20080032324 - Apparatus and method for cell migration assays: The present invention is directed to a method and apparatus for detecting and analyzing cell migration. More specifically, the present invention is directed to novel technology for analyzing cellular movement, including whole cell migration and subcellular component movement. Cells are distributed onto a substrate and monitored for migration or movement.... Agent: Dorsey & Whitney LLP Intellectual Property Department

20080032325 - Phase subtraction cell counting method: A method and device are provided for counting cells in a sample of living tissue, such as an embryo. The method involves obtaining a microscopic image of the unstained tissue that reveals cell boundaries, such as a differential interference contrast (DIC) image, and an optical quadrature microscopy (OQM) image which... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20080032327 - Method and apparatus for detecting the presence of microbes with frequency modulated multi-wavelength intrinsic fluorescence: Method and apparatus for the detection of microbes in liquids, in air and on non-living surfaces in which samples are exposed to frequency-modulated electromagnetic radiation of specific energies capable of exciting various metabolites, cofactors and cellular and spore components, with the microbial cells to be sampled (and more specifically the... Agent: K.s. Cornaby

20080032329 - Cell-free protein synthesis method with the use of linear template dna and cell extract therefor: It is provided a simple and efficient process for producing a large amount of protein in a cell-free protein synthesis system, through a continuous synthesis reaction over a long time using a linear DNA as a template. The continuous synthesis reaction is carried out for at least one hour with... Agent: Birch Stewart Kolasch & Birch

20080032331 - Polypeptides having aminopeptidase activity and nucleic acids encoding same: The present invention relates to isolated polypeptides having aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.... Agent: Novozymes, Inc.

20080032336 - Chemokine receptor materials and methods: The present invention provides polynucleotides that encode the chemokine receptors 88-2B or 88C and materials and methods for the recombinant production of these two chemokine receptors. Also provided are assays utilizing the polynucleotides which facilitate the identification of ligands and modulators of the chemokine receptors. Receptor fragments, ligands, modulators, and... Agent: Marshall, Gerstein & Borun LLP

20080032337 - Human gene: The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and... Agent: Sughrue Mion, PLLC

20080032341 - Method and kit for expressing protein under regulation of the expression from repeated sequence formed by gene amplification, and transformant: A method is disclosed for releasing the transcriptional regulation caused by a repeated sequence in a gene, a kit therefor and so on to thereby establish a system capable of producing a protein in a large amount. At least one embodiment of the method can be achieved by any one... Agent: Harness, Dickey & Pierce, P.L.C

20080032339 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080032340 - Peptide motifs for binding avidin or neutravidin: Peptide motifs DXaAXbPXc (SEQ ID NO: 1) or (CDXaAXbPXcCG) (SEQ ID NO: 2) that define binding to avidin or Neutravidin with high affinity, but not to streptavidin. Peptides, polypeptides and other molecules that incorporate this motif may be identified, detected, or purified by methods involving the specific binding of the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080032335 - Polypeptide having activity of unsaturating w3-fatty acid, polynucleotide coding for the polypeptide and use thereof: The present invention provides a polypeptide having a wide substrate specificity and having a ω3 fatty acid desaturation activity, which makes efficiently unsaturated bond at ω3 position, and a polynucleotide coding for the same. By expressing the polypeptide in the organism, mass production of n-3 series PUFAs is enabled. Specifically,... Agent: Drinker Biddle & Reath (dc)

20080032338 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross PC

20080032342 - Chimeric immunogens: Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory... Agent: Sim & Mcburney

20080032343 - Recombinant production of heparin binding proteins: A process for recovering and purifying refolded heparin binding proteins produced in heterologous host cells includes the step of incubation of the solubilized protein with a polyanionic species such as dextran sulfate.... Agent: Genentech, Inc.

20080032345 - Method and tools for analysis of nucleic acids: A method and tools for the analysis of nucleic acids has been disclosed, in particular the present invention relates to the isolation of genomic DNA from cells and its enzymatic modification. The subjects of the present invention are used to analyse the genetic material of organisms. e.g. to establish the... Agent: Cooper & Dunham, LLP

20080032346 - Method of increasing complementarity in a heteroduplex: We describe here an in vitro method of increasing complementarity in a heteroduplex polynucleotide sequence. The method uses annealing of opposite strands to form a polynucleotide duplex with mismatches. The heteroduplex polynucleotide is combined with an effective amount of enzymes having strand cleavage activity, 3′ to 5′ exonuclease activity, and... Agent: Large Scale Biology Corporation

20080032348 - Method of elongating dna chain, method of amplifying dna chain, and microarray for dna chain elongation: Primers for DNA elongation are immobilized onto a substrate having on the surface thereof a polymer substance which contains a first unit having a group derived from a phosphoester composing the hydrophilic section of a phospholipid, and a second unit having an activated ester group, and DNA elongation reaction is... Agent: Smith, Gambrell & Russell

20080032347 - Temperature sensor element for monitoring heating and cooling: Subject of the present invention is a system comprising a cartridge and a device for heating and cooling a mixture in a controlled manner by sensing the temperature of the mixture in said cartridge with at least one sensor element, a device for heating a cartridge comprising a chamber, a... Agent: Townsend And Townsend And Crew, LLP

20080032350 - Alpha-isomaltosylglucosaccharide-forming enzyme, process and uses of the same: The object of the present invention is to provide an α-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an α-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080032349 - Method for producing k5 polysaccharide: The invention concerns a method for producing K5 polysaccharide, comprising a fermentation step from Escherichia coli followed by a purification step.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080032360 - Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.... Agent: Sheridan Ross PC

20080032361 - Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.... Agent: Sheridan Ross PC

20080032362 - Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.... Agent: Sheridan Ross PC

20080032363 - Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.... Agent: Sheridan Ross PC

20080032364 - Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.... Agent: Sheridan Ross PC

20080032365 - Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.... Agent: Sheridan Ross PC

20080032366 - Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.... Agent: Sheridan Ross PC

20080032352 - Production of dha in microalgae in low ph medium: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium... Agent: Sheridan Ross PC

20080032353 - Production of dha in microalgae in low ph medium: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium... Agent: Sheridan Ross PC

20080032354 - Production of dha in microalgae in low ph medium: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium... Agent: Sheridan Ross PC

20080032355 - Production of dha in microalgae in low ph medium: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium... Agent: Sheridan Ross PC

20080032356 - Production of dha in microalgae in low ph medium: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium... Agent: Sheridan Ross PC

20080032357 - Production of dha in microalgae in low ph medium: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium... Agent: Sheridan Ross PC

20080032358 - Production of dha in microalgae in low ph medium: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium... Agent: Sheridan Ross PC

20080032359 - Production of dha in microalgae in low ph medium: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium... Agent: Sheridan Ross PC

20080032351 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS... Agent: Sheridan Ross PC

20080032367 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross PC

20080032368 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross PC

20080032369 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross PC

20080032370 - Process for producng hydroxycarboxylic acid: Hydroxycarboxylic acids including glycolic acid are promising compounds for use as a raw material for polymers or an intermediate for medicines. However, the processes for the production of hydroxycarboxylic acids which are presently known have a problem that none of them can supply an inexpensive high-purity hydroxycarboxylic acid. An object... Agent: Buchanan, Ingersoll & Rooney PC

20080032371 - Immobilized tal biocatalyst for production of para-hydroxycinnamic acid: TAL cell biocatalyst was immobilized in alginate cross-linked beads using low concentrations of glutaraldehyde. The biocatalyst beads have highly stable TAL activity and mechanical strength such that they withstand prolonged recycling in production of pHCA.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080032372 - Production of stilbenes in plant hairy root cultures: Improved methods for production of stilbenoids including resveratrol, pinosylvin and their respective derivatives are provided, including producing hairy roots from plant cells and eliciting production of the stilbenes. The plant cells in an embodiment are infected by Agrobacterium to produce hairy roots, and contacted with substances which elicit production of... Agent: Patricia A. Sweeney

20080032373 - Process of producing a fermentation product: The invention relates to a process of producing a fermentation product, such as ethanol, from starch-containing material, including i) subjecting starch-containing material to an alpha-amylase, ii) subjecting the material obtained in step i) to an alpha-glucosidase and/or a maltose-generating enzyme, and iii) fermenting the material in the presence of a... Agent: Novozymes North America, Inc.

20080032374 - Method for the preparation of lysine by fermentation of corynebacterium glutamicum: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of... Agent: Lahive & Cockfield, LLP

20080032375 - Method and fermenter for the anaerobic fermentation of biological waste: The invention relates to a method for the anaerobic fermentation of biological waste and a fermenter for carrying out said method. According to the invention, the starting material, in other words, the biological waste for treatment, is introduced through several inlet openings distributed along the reactor height or length and/or... Agent: Oliff & Berridge, PLC

20080032376 - Method for preparing an enzyme containing granule: The invention relates to an enzyme-containing granule comprising a core unit and a shell unit, wherein the core unit comprises the enzyme and is enclosed in a shell unit which is substantially enzyme-free, the ratio between the diameter of the granule and the diameter of the core unit being at... Agent: Novozymes North America, Inc.

20080032377 - Uracil-dna nuclease: protein enzyme possessing nuclease activity specific for uracil containing nucleic acid, process for its preparation and methods of use: A uracil-specific endonuclease enzyme is discovered in specific developmental stages of Drosophila melanogaster. The protein responsible for this enzymatic activity has been isolated, cloned, sequenced, and expressed to practical homogeneity. Sequence homologues have been identified from four additonal organisms. The activity of this enzyme is strictly specific for uracil-containing DNA... Agent: Vince Grolmusz

20080032378 - Polypeptides having amylase activity and methods of making and using them: This invention relates generally to polypeptides and peptides having an amylase activity, e.g., enzymes, polynucleotides encoding the enzymes, the use of such polypeptides and peptides. In one aspect, the polypeptides having amylase activity have increased activity and stability at acidic, neutral and alkaline pH and increased temperature. In one aspect,... Agent: Verenium C/o Mofo S.d.

20080032379 - Pyrenyloxysulfonic acid flurescent agents: The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are... Agent: Invitrogen Corporation C/o Intellevate

20080032380 - Method and apparatus for a miniature bioreactor system for long-term cell culture: A bioreactor and method that permits continuous and simultaneous short, moderate, or long term cell culturing of one or more cell types or tissue in a laminar flow configuration is disclosed, where the bioreactor supports at least two laminar flow zones, which are isolated by laminar flow without the need... Agent: Robert W Strozier, P.l.l.c

20080032381 - Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.... Agent: Sheridan Ross PC

20080032382 - Methods and compositions for degradation of nitroaromatic and nitramine pollutants: The invention relates to novel Methylobacterium species that are capable of degrading nitroaromatic and nitramine compounds. Compositions, kits and methods of using the Methylobacterium species for the degradation of nitroaromatic and nitramine pollutants are provided. More specifically, compositions and methods for the degradation or bioremediation of nitroaromatic and nitramine explosives... Agent: Edwards Angell Palmer & Dodge LLP

20080032383 - Microbial materials for degradation of oils and toxic chemicals: Provided is microbial materials for degradation of oils and toxic chemicals. The microbial material comprises (a) a microorganism and culture filtrate capable of degrading oil and toxic chemicals being at least one selected from the group consisting of Trichosporon loubieri Y1-A of deposit No. KCTC 10876BP, Trichosporon cutaneum, and white-rot... Agent: Birch Stewart Kolasch & Birch

20080032384 - Pharmaceutical preparation containing bacterial cell wall skeleton: The present invention provides a lyophilized formulation comprising bacterial cell wall skeleton, an oil and a surfactant, characterized in that it comprises an antioxidant; for example, an oil-in-water emulsion formulation comprising BCG-CWS and an oil and a lyophilized formulation thereof which contains tocopherols as an antioxidant and further a buffer... Agent: Birch Stewart Kolasch & Birch

20080032385 - Novel antimicrobial peptide isolated from penaeus monodon: The present invention provides an antimicrobial peptide, monodoncin, which is isolated and purified from Penaeus monodon and is capable of being mass produced by molecular cloning techniques in a heterologous expression system, such as yeast. Monodoncin demonstrates a wide-range of bacteriostatic and bactericidal effects on G (−) and G (+)... Agent: Venable

20080032386 - Stabilized proline transporter: The present invention relates to a stabilized proline transporter Put4 obtained by gene mutation and a gene encoding the same, as well as a Saccharomyces yeast strain which is obtained by yeast transformation with the gene and is capable of efficiently using proline in a source material such as wort.... Agent: Drinker Biddle & Reath (dc)

20080032387 - Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.... Agent: Sheridan Ross PC

20080032388 - Live genetically attenuated malaria vaccine: Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a liver-stage-specific gene function.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20080032389 - Disposable bioreactor vessel port: t

20080032390 - Method and device for control of diffusive transport: A method and apparatus are provided for regulating diffusive transport of particles between first and second portions of a channel network in a microfluidic device. The first and second portions of the channel network are in fluid communication. A first object is deposited in a first portion of the channel... Agent: Boyle Fredrickson S.c.

20080032391 - Inspection apparatus: Disclosed is an inspection apparatus that includes a cartridge including a container which is at least partially structured with an elastic member, the container including inside thereof a plurality of rooms to contain solution and a passage to connect the plurality of rooms; and a housing which is arranged with... Agent: Sughrue Mion, PLLC

20080032392 - Covering device: The invention relates to a covering construction in a flexible device for covering heaped or stacked material, in particular for the aerobic treatment of organic-containing waste, for example residual waste or domestic refuse, in a compost heap. The covering construction has a cover which comprises a number of support elements... Agent: W. L. Gore & Associates, Inc.

20080032393 - Covering device: The invention relates to a covering construction in a flexible device for covering heaped or stacked material, in particular for the aerobic treatment of organic-containing waste, for example residual waste or domestic refuse, in a compost heap. The covering construction has a cover which comprises a number of support elements... Agent: W. L. Gore & Associates, Inc.

20080032394 - Ethanol production from biological wastes: The invention provides methods, apparatuses, and kits for producing ethanol and other alcohols. The methods involve fermenting organic material in a fermentation mixture to a biogas comprising methane; converting at least a portion of the biogas to synthesis gas comprising CO and H2; and contacting at least a portion of... Agent: Cyr & Associates, P.A.

20080032395 - Compost heat exchanger: A device for producing compost and heat from composting, comprises a container for creating, containing, and transferring the compost and the heat. The container comprises a hatch for transferring feedstock into the container and for transferring the compost out of the container, and also comprises conduit bearing a heat-transfer medium,... Agent: Gowling, Lafleur Henderson LLP

20080032396 - Bioreactor and method: The bioreactor is for use in performing biological and/or biochemical reactions and includes a vessel, an agitator, a reaction assembly, and a harvesting outlet. The vessel of the bioreactor includes several ports including a mixing port, a reaction port, and a harvesting port. The agitator extends through the mixing port... Agent: David W. Highet, Vp And ChiefIPCounsel Becton, Dickinson And Company

20080032398 - Automated bioculture and bioculture experiments system: The present invention provides a feedback controlled bioculture platform for use as a precision cell biology research tool and for clinical cell growth and maintenance applications. The system provides individual closed-loop flowpath cartridges, with integrated, aseptic sampling and routing to collection vials or analysis systems. The system can operate in... Agent: Thelen Reid Brown Raysman & Steiner LLP

20080032397 - Substructure for cultivating cells and its use: A substructure for cultivating cells including well-like culture sites separate from each other. The cultivation substructure is closed from above hermetically with a lid which, together with the substructure, limits an air space being common to the culture sites and having a gas inlet and a gas outlet. Water has... Agent: Venable LLP

20080032399 - Method and kits for preparing multicomponent nucleic acid constructs: The invention provides a highly efficient, rapid, and cost effective method of linking nucleic acid components in a predetermined order to produce a nucleic acid multicomponent construct. The invention further provides nucleic acid components, each nucleic acid component comprising a double stranded nucleic acid molecule having at least one single... Agent: Ropes & Gray LLP Patent Docketing 39/41

20080032400 - Multimeric elp fusion constructs: ELP fusion proteins, multimeric ELP spider complexes formed of ELP fusion proteins, and methods of using the same. The construct may be in the form of an ELP spider structure complex including multi-leg moieties comprising ELP fusion proteins capable of forming covalent disulfide bonds. The multimeric fusion constructs may be... Agent: Intellectual Property / Technology Law

20080032401 - Placental stem cell populations: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.... Agent: Jones Day

20080032402 - Method for the discrimination and isolation of mammary epithelial stem and colony-forming cells: The present invention relates to an improved method that permits the differential isolation of mouse mammary stem cells and colony forming cells (CFCs). The method involves depletion of non-epithelial cells from freshly dissociated mouse mammary tissue by incubation with an antibody composition containing antibodies specific for CD45, Ter119, CD35 and... Agent: Bereskin And Parr

20080032403 - Production of cell culture product and material for use in said production: A base plate for use in cell culture which comprises a base material, a water-repellent layer having a water-repellent surface formed on the above base material and a hydrophilic surface having a prescribed pattern formed on the base material; a method for producing the above base plate; and a method... Agent: Amin, Turocy & Calvin, LLP

20080032404 - Method for constructing eukaryotic cells having multiple genomic deletions and/or insertions: The present invention provides methods for engineering multiple genomic deletions and/or insertions in eukaryotic cells.... Agent: Banner & Witcoff, Ltd.