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Chemistry: molecular biology and microbiology January USPTO class listing 01/08

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
01/31/2008 > patent applications in patent subcategories. USPTO class listing

20080026362 - Three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes, and preparation process and uses of the same: Disclosed herein is a three-dimensional culture containing human articular chondrocytes with induced terminal differentiation changes, as well as a process for preparing the same. The three-dimensional culture, which was found to mimic the biological characteristics of articular chondrocytes that undergo terminal differentiation in vivo, can be used as a tool... Agent: Townsend And Townsend And Crew, LLP

20080026364 - Identification of leucocytes bearing diagnostic markers for transmissible spongiform encephalopathies: The invention provides a simple method for diagnosing a non-symptomatic or symptomatic human or animal with transmissible spongiform encephalopathy.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080026373 - Assays based on light emission from analyte complexes within a cassette: Assays based on probes attached to surfaces enclosed within cassettes and cassettes and reading stations for the assays. After liquids flow over the probe or probe array to form an array of photo-emissive analyte complexes, and prior to reading, (a) liquid is removed by flow, and (b) a drying gas... Agent: Fish & Richardson PC

20080026369 - Chemical analysis using dynamic viscometry: The invention relates to a method for determining the reactive state of a chemical reaction process in a reaction mixture (110), in particular an amplification reaction for nucleic acids. Said method comprises a viscosity determination, which preferably uses a dynamic viscometer (1). The invention also relates to an improved dynamic... Agent: Sughrue Mion, PLLC

20080026383 - Chronic lymphocytic leukaemia: The invention relates to materials and methods for evaluating the prognosis of a patient presenting with chronic myelogenous leukaemia (CLL) and for CLL therapy.... Agent: Marshall, Gerstein & Borun LLP

20080026374 - Compositions and methods for isolation of biological molecules: The present invention provides charged separation media, kits comprising the separation media, and methods of using the same to bind and optionally isolate biological molecules. The charged separation media and methods utilize a polyion non-covalently bound to the separation media to bind the desired biological molecule to the separation media.... Agent: Senniger Powers (sgm)

20080026375 - Compositions and methods for isolation of biological molecules: The present invention provides charged separation media, kits comprising the separation media, and methods of using the same to bind and optionally isolate biological molecules. The charged separation media and methods utilize a polyion non-covalently bound to the separation media to bind the desired biological molecule to the separation media.... Agent: Senniger Powers (sgm)

20080026382 - Enzymatic labeling of rna: Methods are described in which a sample containing RNA is contacted with an enzyme having an RNA ligation activity in the presence of a labeled substrate to provide labeled RNA. Methods of performing an array analysis of a labeled RNA sample are also described.... Agent: Agilent Technologies Inc.

20080026376 - Kex2 cleavage regions of recombinant fusion proteins: The invention relates to a fusion DNA construct comprising a KEX2 region comprising a KEX2 site and a KEX2 site pre-sequence immediately 5′ to the KEX2 site, a fusion polypeptide, vectors and cells comprising the fusion DNA construct, methods for producing desired proteins from filamentous fungal cells and methods for... Agent: Lynn Marcus-wyner Genecor International, Inc.

20080026370 - Method for geno-and pathotyping pseudomonas aeruginosa: The invention relates to a method for genotyping and pathotyping bacteria of the species Pseudomonas aeruginosa by means of hybridization assays on a biochip or microarray. The invention further relates to specific oligonucleotide probes, which can be employed within the scope of the detection method, as well as to biochips... Agent: Steptoe & Johnson LLP

20080026368 - Method for the specific rapid detection of beverage-spoiling microorganisms: The invention relates to a method for the specific rapid detection of beverage-spoiling micro-organisms by means of in situ hybridisation. The invention also relates to specific oligonucleotide probes that are used in the detection method, and to kits containing said oligonucleotide probes.... Agent: Knobbe Martens Olson & Bear LLP

20080026379 - Nucleotide analogs: The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080026380 - Nucleotide analogs: The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080026381 - Nucleotide analogs: The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20080026378 - Prediction and prophylactic treatment of type 1 diabetes: An in vitro method for predicting the onset of type 1 diabetes (T1D) in a subject, comprises the steps of: (a) measuring the concentration of at least one amino acid, amino acid derivative or amino acid metabolite in a biological sample taken from the subject; (b) determining the subject's HLA... Agent: Dinsmore & Shohl LLP

20080026377 - Skin wrinkle application of genomic replacement therapy: Genomic Replacement Therapy uses the human genome found in mantle dentin of a patient's tooth to affect other cells of the body. Mantle Dentin cells in the developed tooth do not reproduce, therefore the DNA is “younger”. Replacing the genome with a “younger” one will hopefully return youthful appearances to... Agent: John M. Pavelchik

20080026405 - Biomarkers of mild cognitive impairment and alzheimer's disease: A method for quantifying a neurodegenerative disorder in a patient that includes obtaining a fluid sample from the subject; measuring a protein biomarker complex in said fluid sample and correlating the measurement with mild cognitive impairment or Alzheimer's disease status. The biomarkers include those that comprise at least one of... Agent: Stites & Harbison PLLC

20080026411 - Diagnostic and prognostic methods and compositions of matter for cell proliferative diseases: A method for diagnosing a cell proliferative disease expressing DcR3/TR6 in a patient, which comprises the step of measuring the concentration of DcR3/TR6 in the patient's blood, plasma or serum sample, wherein a concentration of DcR3/TR6 higher than that present in the serum of a patient not suffering of a... Agent: Goudreau Gage Dubuc

20080026414 - Method for the determination of the formation of endothelins for medical diagnostic purposes, and antibodies and kits for carrying out such a method: The invention relates to an in vitro method for detecting the formation of endothelins during serious illnesses, especially cardiovascular diseases, inflammations, sepsis and cancer, in whole blood, plasma or serum of a human patient for medical diagnosis. Using this method, relatively long-lasting peptide fragments, especially a C-terminal peptide fragment, of... Agent: Heslin Rothenberg Farley & Mesiti PC

20080026416 - Model taste cells and methods of use for identifying modulators of taste sensation: The present invention provides model taste cells that naturally or recombinantly express taste receptors and relevant cellular proteins and/or molecules useful for taste signal transduction. The present invention further provides methods of use for these model taste cells for screening for compounds that modulate sweet and/or other taste signal transduction.... Agent: Sutherland Asbill & Brennan LLP

20080026419 - Method and systems for tissue culture: Systems and methods for providing dynamic mechanical loading and mechanical property assessment of tissue cultures in open dish cultures are provided. An actuator may be provided under a cell culture dish for driving the dish upward toward a fixed post member, thereby providing controlled compression of a tissue sample.... Agent: Kolisch Hartwell, P.C.

20080026425 - High-cell density fed-batch fermentation process for producing recombinant protein: Methods for producing proteins, for example, recombinant meningococcal 2086 proteins, using fed-batch fermentation with continuous input of an inducer after achieving a threshold parameter, and optionally continuous input of a carbon source, for example, a constant rate input, to improve protein yields, as well as high density protein compositions and... Agent: Hunton & Williams LLP Intellectual Property Department

20080026361 - Sperm cryoprotective media: Described herein is a composition that comprises a cryoprotectant; a membrane protectant that stabilizes or assists in stabilization of membranes of sperm; and a free radical scavenger (e.g., a reducing agent, an antioxidant).... Agent: Wolf Greenfield & Sacks, P.C.

20080026363 - Acetyl coa carboxylase 2 sequences and methods: The present invention relates generally to novel nucleotide and amino acid sequences, and more particularly to novel human acetyl CoA carboxylase 2 (ACC2) and rat ACC2 sequences. The sequences provided herein can be expressed in a recombinant format. Methods of isolating the ACC2 sequence are also provided, which can be... Agent: Louis J. Wille Bristol-myers Squibb Company

20080026366 - Biological fixative and method of using the biological fixative: A composition that includes an aldehyde, alcohol, and a ketone, the volumetric ratio of the alcohol to the ketone in the composition ranging from as low as about 0.8:1 to as high as about 4.5:1 and the volumetric ratio of the alcohol to the aldehyde in the composition ranging from... Agent: Law Office Of Phillip F. Fox

20080026365 - Hemostasis assay: Provided is a hemostasis assay comprising a reaction mixture comprising a blood product to be tested, a trigger molecule for inducing thrombin generation, a thrombin-specific substrate which, upon cleavage by thrombin, produces a measurable thrombin-specific signal, a trigger molecule for inducing plasmin generation, a plasmin-specific substrate which, upon cleavage by... Agent: Frommer Lawrence & Haug

20080026388 - Assay for measuring an enzyme's capability to modify supercoil topology of nucleic acids and modulators: Provided are methods, such as high throughput methods, of assessing or measuring the ability of an enzyme to modify the supercoil topology of a target nucleic acid, the methods comprising the steps of: (a) providing a solid support to which a capture nucleic acid is or may be immobilised, which... Agent: Speckman Law Group PLLC

20080026391 - Blood diagnosis method for dialysis patient and dialysis machine: Provided is a blood diagnosis method of providing a diagnostic marker which is general and which contributes to dialysis treatment and evaluation of clinical effects. The method includes a step of collecting blood samples from a dialysis patient before and/or after dialysis and a step of performing a gene diagnosis... Agent: Sughrue Mion, PLLC

20080026390 - Diagnosis of fetal abnormalities by comparative genomic hybridization analysis: The present invention provides systems, apparatuses, and methods to detect the presence of fetal cells when mixed with a population of maternal cells in a sample and to test fetal abnormalities, e.g. aneuploidy. The present invention involves performing comparative genomic hybridization (CGH) analysis when fetal cells are present in a... Agent: Wilson Sonsini Goodrich & Rosati

20080026397 - Electrochemical method to measure dna attachment to an electrode surface in the presence of molecular oxygen: The present disclosure provides methods and compositions for conducting an assay to detect a polynucleotide. In particular, ruthenium complexes having reduction potentials that do not coincide with the reduction potential of molecular oxygen are disclosed and amperometric techniques for their use are described. In preferred embodiments, the ruthenium complex is... Agent: Knobbe Martens Olson & Bear LLP

20080026372 - In vitro processes for producing multiple copies of primer sequence-free specific nucleic acid: This invention provides inter alia an in vitro process for producing multiple specific nucleic acid copies in which the copies are produced under isostatic conditions, e.g., temperature, buffer and ionic strength, and independently of any requirement for introducing an intermediate structure for producing the copies. In other aspects, the invention... Agent: Enzo Biochem, Inc.

20080026386 - Irf-5 haplotypes in systemic lupus erythematosus: Methods and materials involved in diagnosing SLE are provided herein. The methods and materials can be used to diagnose SLE and/or assess a mammal's susceptibility to develop SLE, based on the presence or absence of one or more IRF-5 variants.... Agent: Fish & Richardson P.C.

20080026396 - Method and nucleic acids for the analysis of astrocytomas: Chemically modified genomic sequences, oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA. In addition, a method for ascertaining genetic and/or epigenetic parameters of genes for use in the characterization, classificaiton, differrentiation, grading, staging, treatment and/or diagnosis of astrocytomas, or the predisposition to astrocytomas.... Agent: Davis Wright Tremaine, LLP/seattle

20080026392 - Method for identifying novel genes: Methods and compositions for identifying novel genes that share regions of homology with known genes from target groups of genes of interest are provided. The methods comprise systematically designing oligonucleotide primers that are specific for regions of homology within the nucleotide sequences of a target group of known genes and... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20080026395 - Method of detection of prostate cancer: The present invention provides methods and kits useful for detecting neplasia by measuring the methylation level of biomarkers, especially the promoter region of GSTP1 for the detection of prostate adenocarcinoma.... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP

20080026399 - Method of treating bladder and lower urinary tract syndromes: The present invention relates to bladder and lower urinary tract syndromes, particularly, irrative symptoms, and to a method of treating same using α1d-adrenergic receptor (α1ddAR) antagonists. The invention further relates to a method of screening compounds for their ability to serve as α1dAR selective antagonists.... Agent: Nixon & Vanderhye, PC

20080026393 - Method to produce single stranded dna of defined length and sequence and dna probes produced thereby: A method for producing a single stranded DNA (ssDNA) molecule of a defined length and sequence is disclosed. This method enables the preparation of, inter alia, probes of greater length than can be chemically synthesized. The method starts with a double stranded molecule, such as genomic, double stranded DNA (dsDNA)... Agent: Peters Verny , L.L.P.

20080026387 - Methods and compositions for detection of a target nucleic acid sequence utilizing a probe with a 3' flap: The invention provides compositions, kits and methods of generating a signal indicative of the presence of a target nucleic acid sequence in a sample by forming a cleavage structure. The cleavage structure is formed by incubating a sample containing a target nucleic acid with a downstream probe that forms a... Agent: Agilent Techologies Inc

20080026384 - Methods and compositions for the detection of bovine pregnancy: Provided herein are pregnancy specific marker genes, such as those shown in Tables I-III, and methods of detecting the same to determine bovine pregnancy.... Agent: Dann, Dorfman, Herrell & Skillman

20080026367 - Methods for genomic analysis: The present invention relates to business methods for discovery of therapeutic and diagnostic products by identifying variations that occur in the human genome, relating these variations to one another, and, ultimately, relating these variations to the genetic bases of phenotype such as disease resistance, disease susceptibility or drug response.... Agent: Perlegen Sciences, Inc. Legal Department

20080026394 - Methods of detecting one or more cancer markers: The present invention provides a methods and compositions for early diagnosis of cancer by rapid and specific detection of one or more cancer markers in a sample.... Agent: Patton Boggs LLP

20080026400 - Methods to identify biologically active agents and synergistic combinations: Methods are described using a particular type of assay system, the Multi-Pathway High Throughput Assay, in conjunction with a novel experimental strategy, whereby repeated cycles of experiments result in the identification of the most effective synergistic combinations of potential active agents from a library of materials. The novel experimental strategy... Agent: Ian R. Scott

20080026398 - Nucleic acid sequences for detecting genetic markers for cancer in a biological sample: Nucleic acid sequences for detecting the presence of nucleic acids, particularly mRNA, encoding human prostate-associated genetic markers encoding prostate-specific antigen (PSA), prostate specific membrane antigen (PSMA) or human kallikrein 2 (hK2) are disclosed. Preferred combinations of nucleic acid sequences amplifying and detecting the prostate-associated genetic markers RNA, used in methods... Agent: Gen Probe Incorporated

20080026385 - Oligonucleotides for cancer diagnosis: The present invention provides sets of oligonucleotides corresponding to genes encoding proteins involved in protein synthesis and/or stability or genes encoding proteins involved in the regulation of defence and/or chromatin remodelling for use in preparing transcript patterns particularly for cancer diagnosis. The invention also extends to such sets and kits... Agent: Sughrue Mion, PLLC

20080026401 - Polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, bgs42: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention... Agent: Louis J. Wille Bristol-myers Squibb Company

20080026371 - Protein c and endothelial protein c receptor polymorphisms as indicators of subject outcome: The invention provides methods and kits for obtaining a prognosis for a subject having or at risk of developing an inflammatory condition and for identifying subjects having a greater benefit from treatment with an anti-inflammatory agent or an anti-coagulant agent. The method generally comprises determining a protein C and/or EPCR... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080026389 - Screen for anti-infective compounds: The present invention provides methods and compositions for identifying compounds useful as therapeutics and disinfectants. Such compounds would be particularly useful in treating Gram-positive bacterial infections. Such therapeutics would target the interaction of a tRNA molecule with an mRNA molecule, interrupting translation of the mRNA molecule and thus interfering with... Agent: Myers Bigel Sibley & Sajovec

20080026404 - Chimeric human t1r3 taste receptor polyptides and compositions containing same: Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in taste signaling, and the genes and cDNA encoding the same, are described, along with methods for isolating such genes and for isolating and expressing such receptors.... Agent: Hunton & Williams LLP Intellectual Property Department

20080026402 - Hematopoietin receptors hpr1 and hpr2: This invention relates to human and murine HPR1 and human and murine HPR2 polypeptides, new members of the hematopoietin receptor polypeptide family; to methods of making such HPR1 and HPR2 polypeptides; to non-human mammals in which the endogenous genomic sequences encoding HPR1 and/or HPR2 polypeptides have been partially or completely... Agent: Immunex Corporation Law Department

20080026403 - Methods, particles, and kits for determining activity of a kinase: Methods, particles and kits for determining kinase activity within a sample are provided. An embodiment of a method includes exposing a fluorescent particle to an assay, wherein the fluorescent particle includes a support substrate having one or more fluorescent materials and a peptide substrate coupled to the support substrate via... Agent: Daffer Mcdaniel LLP

20080026406 - Method for diagnosis of myelodysplastic syndromes (mds): The present invention provides a method of diagnosing a mylodysplastic syndrome, a method of ascertaining the clinical course of a myelodysplastic syndrome or a method of ascertaining response to a therapy regimen in a subject diagnosed with a myelodysplastic syndrome, and kits for effecting the same.... Agent: Pearl Cohen Zedek Latzer, LLP

20080026410 - Biomarkers for bladder cancer: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying bladder cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as bladder cancer or non-bladder cancer. The biomarkers can be detected by SELDI mass spectrometry.... Agent: Foley And Lardner LLP Suite 500

20080026407 - Covalent tethering of functional groups to proteins: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate. Substrates for hydrolases comprising one... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20080026408 - Isolation of analytes: The disclosure features, inter alia, methods and compositions for detecting, isolating, and/or analyzing one or more analytes such as, but not limited to, biomolecules (e.g., proteins, glycoproteins, lipids (e.g., sphingolipids), and carbohydrates). Such methods and compositions are useful in, e.g., the discovery of novel proteins, or the amino acid sequence... Agent: Fish & Richardson PC

20080026409 - Salt-sensitive hypertension: Identification of compositions of biomarkers which diagnose and distinguish between salt-sensitive hypertension, salt-resistant hypertension, salt-independent hypertension and/or hypertensive disorders comprise identifying varying levels of biomarkers in each patient as compared to normal patients. Methods for the identification of novel biomarkers and determination of minimal maximally effective doses of pharmaceutical agents... Agent: Akerman Senterfitt

20080026412 - Beta-2 microglobulin as a biomarker for peripheral artery disease: The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.... Agent: Townsend And Townsend And Crew LLP

20080026413 - Complexes and methods: The invention relates to a cell comprising an exogenous capture moiety on its cell surface, wherein said capture moiety is capable of supporting the attachment of an HLA molecule thereto. In another aspect the invention relates to a cell comprising a capture moiety on its cell surface, and an HLA... Agent: Frommer Lawrence & Haug

20080026415 - Methods for making cancer prognoses based on subcellular localization of biomarkers: This invention provides a method of making a prognosis for a patient afflicted with a type of cancer such as colon cancer, based upon quantification of biomarkers such as thymidylate synthase in subcellular compartments.... Agent: Cooper & Dunham, LLP

20080026417 - Assays for trichomonal and other hydrolases: The release by trichomonads of a hydrolase that hydrolyzes a narrowly defined class of substrates at a low pH without interference from hydrolases that are unrelated to trichomoniasis is the basis for a selective diagnostic assay for trichomoniasis that measures hydrolysis of any of these substrates by vaginal fluid at... Agent: Townsend And Townsend And Crew, LLP

20080026418 - Device and direct method for detecting antibiotic-inactivating factors: The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present... Agent: Stinson Morrison Hecker LLP Attn: Patent Group

20080026420 - Systems and methods for automated analysis of cells and tissues: Systems and methods for rapidly analyzing cell containing samples, for example to identify morphology or to localize and quantitate biomarkers are disclosed.... Agent: Cooper & Dunham, LLP

20080026426 - Anti-infective therapy: DNA isolates coding for human DNase and methods of obtaining such DNA are provided, together with expression systems for recombinant production of human DNase useful in therapeutic or diagnostic compositions.... Agent: Genentech, Inc.

20080026423 - Dep-1 receptor protein tyrosine phosphatase interacting proteins and related methods: Proteins are identified from human breast tumor cell lines (MDA-MB-231, T-47D and T-47D/Met) that interact specifically with the substrate-trapping mutant form of Density Enhanced Phosphatase-1 (DEP-1). These proteins include the functional component p120 catenin (p120ctn), the adaptor protein Gab 1, and the HGF/SF receptor Met. The invention relates to isolated... Agent: Seed Intellectual Property Law Group PLLC

20080026421 - Method for production of a compound in a eukaryotic cell: The present invention relates to a eukaryotic cell containing peroxisomes that are capable to fuse with a membrane-structure of the cell involved in the secretory pathway of the cell. In this way, the eukaryotic cell is able to release the peroxisomal content outside the cell. The invention also relates to... Agent: Nixon & Vanderhye, PC

20080026422 - Overexpression of aminoacyl-trna synthetases for efficient production of engineered proteins containing amino acid analogues: Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallylglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine.... Agent: Seed Intellectual Property Law Group PLLC

20080026424 - Recombinant histidine-tagged inosine nonophosphate dehydrogenase polypeptides: The invention relates to a modified IMPDH polypeptide wherein the IMPDH polypeptide has a histidine tag and where the subdomain of the IMPDH polypeptide is modified so that the rate stability of the histidine-tagged, modified IMPDH polypeptide is maintained relative to the wild-type IMPDH polypeptide. The invention also relates to... Agent: Roche Diagnostics Operations Inc.

20080026427 - Human cdnas and proteins and uses thereof: The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080026428 - Method for producing nucleotide by fermentation: Nucleoside 5′-phosphate ester is produced by culturing a bacterium belonging to the genus Escherichia having an ability to produce nucleoside 5′-phosphate ester, in which ushA gene and aphA gene do not function normally, in a medium to produce and accumulate nucleoside 5′-phosphate ester in the medium, and collecting the nucleoside... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080026430 - Instrument for heating and cooling: An instrument and method is provided that conveniently allows rapid amplification of nucleic acids.... Agent: Townsend And Townsend And Crew, LLP

20080026429 - Solution pre-treatment: A method of preparing a solution for use in DNA amplification reactions, including the steps of, mixing a binding agent with a base solution; subjecting the mixture (of a binding agent and base solution) to a stimulus which activates the binding agent, and upon activation, the binding agent binding to... Agent: Greer, Burns & Crain

20080026431 - Method for saccharification of woody biomass: Provided is an inexpensive and efficient saccharification method for woody biomass and a method of producing ethanol from woody biomass. A method for saccharification of woody biomass comprising hydrolysis treatment and an enzymatic treatment, in which a pretreatment process is performed prior to the enzymatic treatment and said pretreatment includes... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080026432 - Novel l-threonine importer from corynebacterium and a preparation method of a strain producing l-threonine: The present invention relates to a preparation method of an L-threonine producing strain by utilizing a novel L-threonine importer identified from Corynebacterium glutamicum. The method can be advantageously used for the production of L-threonine by increasing the fermentation concentration of Lthreonine and the yield per unit thereof.... Agent: Birch Stewart Kolasch & Birch

20080026433 - Use of enzymatic resolution for the preparation of intermediates of pregabalin: Provided is the use of enzymatic resolution for the preparation of intermediates of pregabalin, including (3S)-cyano-5-methylhexanoic acid and salts thereof and R-(−)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof.... Agent: Kenyon & Kenyon LLP

20080026434 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross PC

20080026435 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross PC

20080026436 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross PC

20080026437 - Pufa polyketide synthase systems and uses thereof: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA... Agent: Sheridan Ross PC

20080026438 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS... Agent: Sheridan Ross PC

20080026439 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS... Agent: Sheridan Ross PC

20080026440 - Pufa polyketide synthase systems and uses thereof: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS... Agent: Sheridan Ross PC

20080026441 - Production of probiotic bacteria using maple sap: Use of maple sap, down-graded maple syrup or mixture thereof as a carbon and energy source for the production of probiotic bacteria (e.g. Lactobacilli spp.) unexpectedly leads to an improvement in growth of the probiotic bacteria and an improvement in the yield of products produced by the bacteria.... Agent: National Research Council Of Canada 1200 Montreal Road

20080026442 - Ethanol production from biological wastes: The invention provides methods, apparatuses, and kits for producing ethanol and other alcohols. The methods involve fermenting organic material in a fermentation mixture to a biogas comprising methane; converting at least a portion of the biogas to synthesis gas comprising CO and H2; and contacting at least a portion of... Agent: Cyr & Associates, P.A.

20080026443 - Ethanol production from biological wastes: The invention provides methods, apparatuses, and kits for producing ethanol and other alcohols. The methods involve fermenting organic material in a fermentation mixture to a biogas comprising methane; converting at least a portion of the biogas to synthesis gas comprising CO and H2; and contacting at least a portion of... Agent: Cyr & Associates, P.A.

20080026444 - Process for producing protein-polymer complex: By reacting a protein conjugated with a polymer thereto with a compound having a mercapto group and eliminating a polymer ester-bound to a mercapto group of a cysteine residue, a protein-polymer complex can be produced without considerably reducing function of a protein.... Agent: Birch Stewart Kolasch & Birch

20080026445 - Oxygen scavenger coating composition: A coating composition having a multicopper oxidase enzyme and an oxidizable substrate in combination with a organic binder polymer which may be dispersed or dissolved in a non-aqueous liquid vehicle.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080026447 - Assay for determining factor viia inhibitor concentration in plasma samples: This invention provides a method for determining the concentration of a factor VIIa inhibitor in a sample. A method for determining non specific binding of a factor VIIa inhibitor to proteins other than factor VIIa is also provided.... Agent: Louis J. Wille Bristol-myers Squibb Company

20080026446 - Combination of a growth factor and a protease enzyme: A composition combining an extracellular matrix-degrading protease and a growth factor related to epithelial cell functions together without inactivation or degradation of the growth factor by the protease. Preferably, the protease is plasmin/plasminogen or a related one, and the growth factor is KGF or a related one. The combination associates... Agent: Jackson Walker LLP

20080026448 - Production of hiv: The present invention provides methods for producing HIV and HIV antigen by propagating HIV, in particular HIV-1, in cells grown in chemically defined, protein free medium. The invention also provides HIV antigen produced by such methods.... Agent: Mcdermott, Will & Emery

20080026449 - Infectious bronchitis virus vaccine: Embodiments of the present invention generally relate to a novel attenuated infectious bronchitis virus (IBV) of GA-98 isolate. Further, other embodiments of the present invention generally relate to methods of immunizing avian against an infectious bronchitis virus. As well, further embodiments relate to method of making a vaccine and/or immunogenic... Agent: Intervet Inc. Patent Department

20080026450 - Method of leaching copper sulfide ores containing chalcopyrite: A method of recovering copper from copper sulfide ores, characterized by comprising: using a sulfuric acid solution having a chloride ion concentration adjusted to 6 g/L or more but less than 18 g/L and a pH adjusted to 1.6 or more but less than 2.5 as a leaching solution; and... Agent: Birch Stewart Kolasch & Birch

20080026451 - System for isolating biomolecules from a sample: The present invention provides an automated system for purification of a substance of interest. The system generally comprises an instrument for moving fluids through the system, a reagent pack for storing fluids, and a purification cartridge. The cartridge comprises two filtration units for binding substances based on different physical properties.... Agent: Latimer, Mayberry & MatthewsIPLaw, LLP

20080026452 - Device for determining distribution of glycation of erythrocytic membranes: A device for determining the distribution of glycation of erythrocytic membranes includes a container as a cell for electromagnetic-phoresis, a cathode ray and an anode ray which are connected to a direct current power supply, and a magnetic sheet which is placed outside the bottom of the container. The container... Agent: Akin Gump Strauss Hauer & Feld L.L.P.

20080026453 - Sample applicators for analytical assays: A liquid applicator for applying a liquid sample to a liquid receiving surface is disclosed. The liquid applicator comprises a bibulous line to hold a first predetermined volume of liquid for application to a liquid receiving surface. A second predetermined volume less than or equal to the first predetermined volume... Agent: Knobbe Martens Olson & Bear LLP

20080026454 - Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices: A biosensor includes a substrate with a layer of receptive material disposed thereon overlying a layer containing a photo-reactive agent. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the receptive material are defined in the receptive material layer by a... Agent: Dority & Manning, P.A.

20080026455 - Porous chamber for tissue culture in vitro: A porous chamber for tissue culture in vitro. The porous chamber includes a main body made of porous biologically absorbable polymer material, comprising an inner surface surrounding a hollow cavity, the hollow cavity having an aperture opened at an upper surface of the main body, wherein the aperture is communicated... Agent: Birch Stewart Kolasch & Birch

20080026456 - Method and apparatus for reducing pathogens in a biological sample: The present invention is directed to a method and apparatus for disinfection of biological samples, including semen and the like. In a first aspect of the present invention, a method for reducing pathogens in a biological sample includes passing the biological sample through a gradient including an enzyme suitable for... Agent: Suiter Swantz PC Llo

20080026458 - Chimeric and humanized antibodies to alpha5beta1 integrin that modulate angiogenesis: The present invention provides chimeric and humanized antibodies that specifically recognize α5β1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.... Agent: Howrey LLP

20080026457 - Ungulates with genetically modified immune systems: The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous immunoglobulin loci. The present invention also provides ungulate animals, tissue and organs as well as cells and cell lines derived from... Agent: King & Spalding LLP

20080026459 - Isolation, selection and propagation of animal transgenic stem cells: Animal stem cells are obtained and maintained by culturing cells containing, in the genome, a selectable marker. Differential expression of the selectable marker enables preferential survival and/or division of the desired stem cells compared to the non-stem cells.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080026460 - Method for culturing stem cells: A three-dimensional microwell system that supports long term embryonic stem cell (ESCs) culture and formation of homogeneous embryoid bodies (EBs) is described. Microwell-cultured ESCs remain viable and undifferentiated for several weeks in culture and maintain undifferentiated replication when passaged to Matrigel®-coated, tissue culture-treated polystyrene dishes. Microwell-cultured ESCs maintain pluripotency, differentiating... Agent: Quarles & Brady LLP

20080026461 - Tissue-like organization of cells and macroscopic tissue-like constructs, generated by macromass culture of cells and the method of macromass culture: Three-dimensional tissue-like organization of cells by high cell-seeding-density culture termed as macromass culture is described. By macromass culture, cells can be made to organize themselves into a tissue-like form without the aid of a scaffold and three-dimensional macroscopic tissue-like constructs can be made wholly from cells. Tissue-like organization and macroscopic... Agent: Lackenbach Siegel

20080026462 - Meningeal-derived stem cells: Described herein are stem cells derived from the meninges; specifically, the dura mater, pia mater or arachnoid mater. Methods for isolating, differentiating and explanting these cells are described, as well. In particular embodiments, the stem cells of the present invention are differentiated into nerve cells, bone cells, cartilage cells and... Agent: Davis Wright Tremaine LLP/los Angeles

20080026463 - Matrix and method for isolation of hepatic progenitor cells: A method is provided of isolating and propagating hepatic progenitors in vitro on one or multiple extracellular matrix components comprising a collagen in polymeric form. A container for the isolation and propagation of the progenitors comprising culture dishes and/or bioreactors comprising the disclosed matrices is also provided.... Agent: Foley And Lardner LLP Suite 500

20080026464 - Nanotopographic compositions and methods for cellular organization in tissue engineered structures: The present invention relates to tissue engineered compositions and methods comprising nanotopographic surface topography (“nanotopography”) for use in modulating the organization and/or function of multiple cell types.... Agent: Ewards Angell Palmer & Dodge LLP

20080026465 - Cell culturing method using biomechanical stimulation loading and system therefor: To provide a cell culturing method employing biomechanical stimulation loading and its system for applying, in in vitro culture, stimulation similar to vertical weight load stimulation or sideward shear stress stimulation acting on tissues in an aboveground living body as repeated biomechanical stimulation to culture cells, culture tissues or a... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080026466 - S-adenosyl-l-methionine synthetase promoter and its use in expression of transgenic genes in plants: A constitutive plant S-adenosyl-L-methionine synthetase (SAMS) promoter and subfragments thereof and their use in promoting the expression of one or more heterologous nucleic acid fragments in plants are described.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080026467 - Novel agents for the prevention of leishmaniosis: The invention relates to nucleic acid constructions, characterized in that they comprise nucleic acids which are isolated in the sense position and which are capable of coding for an immunogenic protein of promastigotes or amastigotes of Leishmania, said nucleic acids responding to one of the sequences SEQ ID No. 1,... Agent: Nixon & Vanderhye, PC

  
01/24/2008 > patent applications in patent subcategories. USPTO class listing

20080020368 - Method and apparatus for exposing cells to different concentrations of analytes or drugs: A tapered microchannel structure allows individual cells to be reacted with a continuum of concentrations or dosages of an analyte or drug from one sample. A dual sandbag structure that divides up a tapered micro channel into thirds permits performing two simultaneous tests on two different sets of cells isolated... Agent: Robert K. Tendler

20080020369 - Neurotoxicity methods process: A method for testing the cytotoxicity of an implant comprising: providing neuronal cells in-vitro; providing one or more compounds of the implantable medical device; adding the one or more compounds from the implantable medical device to the in-vitro neuronal cells; and determining a measure of the cytotoxicity of the one... Agent: Advanced Neuromodulation Systems, Inc.

20080020373 - Composition for detecting the response of rectal adenocarcinomas to radiochemotherapy: A cDNA array (9984 genes) was used for expression profiling in rectal adenocarcinoma. The expression data were correlated to responsiveness to chemotherapy followed by radiotherapy. A set of 54 genes was found that were differentially expressed in responders vs. non-responders. The genes may be used as prognostic markers for determining... Agent: National Institutes Of Health C/o Venable LLP

20080020395 - Gamma secretase notch biomarkers: The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The reagents and methods of the invention can be utilized before, after, or concurrently with, pre-clinical,... Agent: Louis J. Wille Bristol-myers Squibb Company

20080020380 - Method of denaturing and fragmenting dna or rna using ultrasound: A method and apparatus are provided for processing a DNA or RNA sample within a sample processing module. The method includes the steps of providing a sample well within the sample processing module that contains the DNA or RNA sample, coupling ultrasonic energy from an external source into the sampling... Agent: Welsh & Katz, Ltd. Jon P. Christensen

20080020372 - Methods for detecting and treating cancer: Methods and kits for detecting cancer and monitoring cancer progression are described. The method involves analyzing a sample containing nucleic acids or proteins from a patient for decreased expression of endoglycan and/or increased expression of podocalyxin.... Agent: Bereskin And Parr

20080020384 - Stabilizing composition and stabilizing method of coelenterazine solution for high-throughput measurement of luciferase activity: The present invention relates to a stabilization composition of coelenterazine or an analog thereof, a kit, a method for measuring a coelenterazine-based biological luminescence, containing coelenterazine or the analog thereof and an antioxidant.... Agent: Knobbe Martens Olson & Bear LLP

20080020401 - Immunosuppressant drug extraction reagent for immunoassays: An improved extractive reagent composition and method for extracting an immunosuppressant drug, such as sirolimus, tacrolimus or cyclosporine, from blood samples while yielding a test sample extract that has low vapor pressure and is compatible with immunoassay components. The inventive reagent composition comprises dimethyl sulfoxide (DMSO), at least one divalent... Agent: Vysis, Inc Patent Department

20080020400 - Oxidized apoa-i determination by mass spectrometry: Methods are provided for the detection and quantitation of proteins generally and apolipoprotein A-I and oxidized derivatives thereof in particular. Further provided are methods for the assessment of the risk cardiovascular disease in a subject, wherein the assessment is based on the amount of oxidized and unoxidized apolipoprotein A-I in... Agent: Barry S. Wilson Foley & Lardner LLP

20080020408 - Anti-ube4a/ufd2b polyclonal antibody and its use thereof as diagnostic and prognostic marker of 11q23 region alterations: The subject of this invention is an anti-UBE4A/Ufd2b polyclonal antibody. Moreover, this invention refers to the use of said antibody as a diagnostic and prognostic marker of alterations in the 11q23 region.... Agent: Pearne & Gordon LLP

20080020407 - Identification, isolation and elimination of cancer stem cells: Isolated populations of leukemic stem cells are provided. The cells are useful for experimental evaluation, and as a source of lineage and cell specific products, and as targets for the discovery of factors or molecules that can affect them. Detection of leukemic stem cells is useful in predicting disease progression,... Agent: Bozicevic, Field & Francis LLP

20080020428 - Method of producing meningococcal meningitis vaccine for neisseria meningitidis serotypes a,c,y, and w-135: Methods for producing quadrivalent meningococcal meningitis polysaccharide and conjugate vaccines for serotypes A, C, Y and W-135 disclosed. Neisseria meningitidis fastidious medium was designed to maximize the yield of capsular polysaccharides and generate minimal cellular biomass and endotoxin in a short duration of fermentation. The crude polysaccharides are isolated, purified,... Agent: Jeeri R. Reddy

20080020430 - Enzymatic process for preparing aminoacyl esters of monosaccharides: The present invention particularly relates to lipase mediated synthesis of aminoacyl esters of monosaccarides from unprotected amino acids and monosaccharides in non-polar solvents using lipases.... Agent: Ladas & Parry

20080020370 - Heteroduplex tracking assay: A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations... Agent: Frommer Lawrence & Haug

20080020371 - Reverse genetics system: The complete genomic sequence of maize fine streak virus (MFSV), a negative-strand RNA virus that infects plants and insects, is disclosed. The inventors have characterized the MFSV genome and identified the leader and trailer sequences, seven open reading frames as well as the functions of some of the encoded proteins,... Agent: Quarles & Brady LLP

20080020382 - Biological microbeads for various flow cytometric applications: The invention relates to biological microbeads, and in certain embodiments, to the use thereof in flow-cytometric applications. Biological microbeads are fixed cells that may be surface-modified with proteins or other molecules that have specific binding properties. These surface-bound proteins may bind to target compounds bearing fluorescent labels that facilitate detection... Agent: Davis Wright Tremaine LLP/los Angeles

20080020387 - Biomarker-optimized adhd treatment: Methods of predicting patient responsiveness to treatment of attention-deficit/hyperactivity disorder (ADHD) with selective norepinephrine reuptake inhibitors; identifying individuals requiring a higher than normal dose of atomoxetine for treating ADHD; and predicting patient responsiveness to treatment of neuropsychiatric diseases or disorders responsive to treatment with selective norepinephrine reuptake inhibitors are provided.... Agent: Eli Lilly & Company

20080020396 - Composition for amplifying nucleic acids: The invention relates to a concentrated and buffered liquid composition for amplifying nucleic acids, comprising at least one dNTP, at least one enzyme required for the amplification, at least one oligonucleotide primer, and at least one fluorescent nucleotide probe, in the presence of a polyol and/or of polyvinylpyrrolidone (PVP).... Agent: Jacobson Holman PLLC

20080020398 - Cross-reactive primers for amplifying the nucleic acids of hiv-1 and hiv-2: Compositions, methods and kits for detecting the nucleic acids of HIV-1, HIV-2, or the combination of HIV-1 and HIV-2. Particularly described are oligonucleotides that are useful as hybridization probes and amplification primers, including cross-reacting hybridization probes and cross-reacting amplification primers, for detecting very low levels of viral nucleic acids.... Agent: Gen Probe Incorporated

20080020390 - Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms: The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome.... Agent: Viksnins Harris & Padys Pllp

20080020379 - Diagnosis and prognosis of infectious diseases clinical phenotypes and other physiologic states using host gene expression biomarkers in blood: The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression... Agent: Naval Research Laboratory Associate Counsel (patents)

20080020376 - Enriched cdna expression libraries and methods of making and using same: Disclosed are cDNA expression libraries enriched for cDNAs that encode, for example, secretory and membrane-bound proteins and to methods for making such libraries. Also disclosed are methods for using the cDNA expression libraries disclosed herein to screen for proteins, nucleic acids, and agents that modulate the function and/or expression of... Agent: Needle & Rosenberg, P.C.

20080020378 - Fluorescent base analogues' usage in the characterization of nucleic acid molecules and their interactions: This invention provides methods, apparatus and kits for the quantitative and qualitative characterization of the nucleic acid molecule's behavior by modify the nucleic acid molecules to incorporate selected fluorescent base analogues (FBAs). The methods generally place one or more fluorescent base analogue into a nucleic acid molecule (e.g., an oligonucleotide)... Agent: Yaodong Chen

20080020383 - Haplotype markers and methods of using the same to determine response to treatment: The present invention relates to methods for diagnosing or predicting responsiveness to treatment, such as Alefacept, by determining the presence of a nucleotide at one or more polymorphic sites within a haplotype marker. The present invention identifies multiple haplotypes that are associated with response to Alefacept. The haplotype markers identified... Agent: Leydig Voit & Mayer, Ltd

20080020393 - Iron regulating protein-2 (irp-2) as a diagnostic for neurodegenerative disease: The present invention relates to the discovery of markers for neurodegenerative disease. More particularly, it was discovered that forms of IRP-2 protein that are unable to undergo oxidation at critical cysteine residues are diagnostic for neurodegenerative disease including, but not limited to Alzheimer's disease. Embodiments include nucleic acids that encode... Agent: Knobbe Martens Olson & Bear LLP

20080020394 - Kunitz domain library: Disclosed are libraries, vectors, phage particles, host cells, and methods for displaying a Kunitz domain. The libraries can include Kunitz domains that vary in at least two interaction loops with respect to one another. Varied Kunitz domains can be displayed on phage at a low valency.... Agent: Fish & Richardson PC

20080020391 - Lateral flow methods and devices for detection of nucleic acid binding proteins: Methods and devices are provided for detecting the presence or absence of nucleic acid binding proteins, such as NMP22, and other proteins, in bodily fluids.... Agent: J. Gary Mohr (datascope)

20080020388 - Method for differentiating between multiple sclerosis subtypes: Disclosed herein is a method for differentiating between multiple sclerosis subtypes in a patient. The method comprises a) determining an amount of an IAP gene expression level in a blood sample obtained from the patient; and b) correlating the amount of the IAP gene expression level in the blood sample... Agent: Philip Swain, Phd C/o Gowling Lafleur Henderson

20080020375 - Method of adjudicating on prostate cancer: The present invention relates to a method for determining a subject having a risk of having developed or developing prostate cancer, which comprises the following steps: a) a step of analyzing the presence/absence or level of mutation in the PCA-1 gene derived from the subject; and b) a step of... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080020386 - Methods and apparatus for genotyping: A method for determining the human leukocyte antigen (HLA) genotype of a nucleic acid sample, comprises: contacting a nucleic acid sample with at least one nucleic acid primer set and subjecting the mixture to a nucleic acid amplification reaction; determining the size of any amplification products produced in the amplification... Agent: Dinsmore & Shohl LLP

20080020389 - Methods of detecting a target nucleic acid: The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe. The invention also includes the steps of... Agent: Agilent Techologies Inc

20080020381 - Methods, compositions, and systems for the identification of species-specific or developmental stage-specific insecticides: Ecdysteroid action in Drosophila melanogaster and other insects is mediated by the dimerization of two nuclear receptors, the ecdysone receptor (EcR) and Ultraspiracle (USP), which regulate the transcription of target genes. Disclosed are nucleic acid constructs to identify insecticides having the ability to modify insect development and growth in a... Agent: Kilpatrick Stockton LLP

20080020392 - Motion resolved molecular sequencing: Methods are provided for determining the sequence of a polynucleotide by tracking the motion of a nucleotide-selective, processive enzyme along a template, in a reaction mixture that alters the enzyme movement in a base specific manner. The movement trace of the enzyme is collected, and arranged in temporal order. The... Agent: Bozicevic, Field & Francis LLP

20080020397 - Optimization of crossover points for directed evolution: Methods and devices for more efficiently engineering diversity into recombinant polypeptides and/or nucleic acids are provided herein. For example, a variety of methods of selecting and/or assessing potential crossover sites in an amino acid sequence or a nucleotide sequence are provided, as well as the resulting chimeric product sequences. These... Agent: Beyer Weaver LLP

20080020377 - Peptide-based method for monitorting gene expression in a host cell: The present invention relates a method for monitoring the expression level of a gene in a host cell by modulating the activity of a regulatory biomolecule, comprising the steps of: (a) transforming a cell expressing a regulatory biomolecule with a nucleic acid molecule comprising an open reading frame encoding an... Agent: Reed Smith LLP

20080020374 - Reagents, kits and methods for immunodetection of epitopes on molecules: Methods for detecting and/or quantifying molecules expressing a selected epitope in a sample are disclosed. Methods for profiling proteins in a cell lysate are also disclosed. Kits for detecting and/or quantifying molecules expressing a selected epitope in a sample and kits for profiling proteins in a cell lysate are also... Agent: Cozen O'connor

20080020385 - Use of a genetic modification in the human gnaq gene for predicting risk of disease, the course of disease, and reaction to treatments: In order to determine the risk of disease, the course of a disease, the action of medicaments, the side-effects of medicaments and drug targets, a base substitution is identified in the non-translated region 5′ of the gene for the Gαq sub-unit of human G proteins, preferably the presence of two... Agent: Amster, Rothstein & Ebenstein LLP

20080020403 - Nucleic acid encoding a novel prostaglandin receptor protein and methods of use thereof: Described herein is a novel member of the prostanoid receptor family, a guinea pig prostaglandin D2 receptor. Described are the receptor, the nucleic acid that encodes it, and various uses for both.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080020402 - Polypeptide multilayer films and methods: Polypeptide multilayer films comprising a hydrophobic designed polypeptide, methods of making the polypeptide multilayer films, and methods of designing the hydrophobic polypeptide are disclosed.... Agent: Cantor Colburn, LLP

20080020404 - Search for cancer markers by a novel screening method: The present invention relates to a method of concentrating low molecular weight peptides in the supernatant of serum-free cultured cells, said method comprising allowing the peptides to bind to a strong cation exchanger under an acid condition, and eluting them under an alkali condition to concentrate the peptide. Furthermore, peptides... Agent: Foley And Lardner LLP Suite 500

20080020399 - Use of irs-polypeptides for identifying of pharmaceutically active compounds: An assay for determining the ability of an enzyme, functional fragment, or functional derivative thereof to modify the phosphorylation status of a biotinylated polypeptide.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080020406 - Antibodies to a human kchannel and therapeutic applications thereof: The present invention relates to a novel human K+ ion channel, to nucleic acid molecules encoding the same and to vectors comprising said nucleic acid molecules. The invention additionally relates to antibodies specifically directed to the novel K+ ion channel and to pharmaceutical compositions and diagnostic kits containing at least... Agent: Ropes & Gray LLP Patent Docketing 39/361

20080020409 - Analytical platform and method for generating protein expression profiles of cell populations: The present invention is related to analytical platforms and methods performed therewith for generating qualitative and/or quantitative protein expression profiles, in particular differential protein expression profiles, of cell populations comprising: generating lysates of one or more populations of cells, the lysates comprising a plurality of proteins expressed by the respective... Agent: Norris, Mclaughlin & Marcus, Pa

20080020410 - Assays for detection of bacillus anthracis: This invention provides novel methods, reagents, and kits that are useful for detecting B. anthracis. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, which bind to the surface array protein of B. anthracis.... Agent: Townsend And Townsend And Crew, LLP

20080020405 - Protein binding determination and manipulation: This invention addresses method for determining protein binding sites, molecules which bind to such sites and molecules which inhibit binding to particular protein binding sites. Also considered are conjoined molecules for enhanced binding to specific protein binding sites.... Agent: Thomas M. Saunders Brown Rudnick Berlack Israels LLP

20080020411 - Porous material, composition containing porous material, and sensor comprising porous material: A porous material containing mesopores with immobilized glucose dehydrogenase is provided. The pore size is at least 10 nm.... Agent: Fitzpatrick Cella Harper & Scinto

20080020412 - Aurora expression constructs: The present invention is directed to Aurora constructs that are useful for structural and functional studies of Aurora. Specifically, engineered Aurora enzymes are provided, along with polynucleotides encoding said enzymes, vectors comprising said polynucleotides, and host cells comprising the vectors. In addition, a process of using the engineered Aurora enzymes... Agent: Heller Ehrman LLP

20080020413 - Crystalline visfatin and methods therefor: Crystals of nicotinamide phosphoribosyltransferase, methods of making the crystals, and methods of using the crystals are disclosed. The three-dimensional structures of NMPRTases are also disclosed. Also disclosed are methods for utilizing a crystal structure of an NMPRTase for identifying, designing, selecting, or testing molecules which affect NMPRTase activity, which can... Agent: Sonnenschein Nath & Rosenthal LLP

20080020414 - Cyfra 21-1 as a marker for colorectal cancer: The present invention relates to the assessment of colorectal cancer. It discloses the use of protein CYFRA 21-1 in the assessment of colorectal cancer. It also relates to a method for assessing colorectal cancer in vitro using a liquid sample, derived from an individual by measuring CYFRA 21-1 in said... Agent: Roche Diagnostics Operations Inc.

20080020415 - Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms: Acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, genes encoding diacylglycerol acyltransferase (DGAT1) have been isolated from Y. lipolytica and Mortierella alpina. These genes encode enzymes that participate in the terminal step in oil... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080020416 - Enzyme and preparation method: A method for preparing a soluble protein comprising urokinase-type plasminogen activator (uPA) or an active fragment thereof, or a variant of either of these which has uPA activity, which method comprises contacting said protein with a buffer at a pH of from 8.5-10.5, said buffer comprising a reducing agent and... Agent: Astrazeneca R&d Boston

20080020417 - Biological dataset profiling of asthma and atopy: Methods and systems for evaluating biological dataset profiles relating to asthma and other atopic conditions are provided, where datasets comprising information for multiple cellular parameters are compared and identified, and used in the evaluation of candidate pharmacologic agents for suitability as therapeutic agents.... Agent: Bozicevic, Field & Francis LLP

20080020418 - Cftr polypeptides, fragments thereof and methods of use to overcome biosynthetic misprocessing: The invention relates to biosynthetic maturation of cell surface polypeptides and, more specifically, to particular CFTR polypeptides which exhibit increased transport to the cell surface and tripeptide amino acid sequences that promote or enhance transport of export-incompetent CFTR to the cell surface.... Agent: Fish & Richardson P.C.

20080020419 - The use of saccharomyces cerevisiae erg4 mutants for expressing mammalian glucose transporter: The invention relates to yeast strains in which a human GLUT4 transport or a human GLUT1 transporter can be functionally expressed and to particular GLUT4 transport proteins which can be functionally expressed particularly readily in yeast strains.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20080020421 - Methods of screening agents for cytotoxic and antimicrobial activity: The present invention provides for methods of screening agents for cytotoxic and/or anti-microbial activity. In particular embodiments, the loss of a fluorescent signal from the treated cells, due to cell death or inhibition of growth, is measured for several different cell types in parallel.... Agent: Fulbright & Jaworski L.L.P.

20080020420 - Oligosaccharides in a test system for the determination of the presence of an antibiotic in a fluid: Provided is a test system, a test method and a test kit for the determination of the presence of an antibiotic in a fluid based on a test medium comprising a test organism, at least one substance that provides a solid state, nutrients and an indicator, wherein the end-pH of... Agent: Nixon & Vanderhye, PC

20080020422 - Methods and compositions for the detection of microbial contaminants: The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the invention provides a test cartridge useful in the practice of hemocyte lysate-based assays for the detection and/or quantification of a microbial... Agent: Goodwin Procter LLP Patent Administrator

20080020423 - Enzyme reactions in miniemulsions: The present invention is directed towards an asymmetric enzymic process for preparing optically active organic compounds. The process according to the invention is carried out in what are termed miniemulsions. The invention also relates to an enzymic reaction mixture which exhibits a miniemulsion.... Agent: Law Office Of Michael A. Sanzo, LLC

20080020424 - Heteromeric umami t1r1/t1r3 taste receptors and isolated cells that express same: The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of... Agent: Hunton & Williams LLP Intellectual Property Department

20080020427 - Method for producing alpha-1, 6-branched alpha-1, 4-glucans from sucrose: Nucleic acid molecules which encode a branching enzyme from a bacterium of the genus Neisseria, vectors, host cell, plant cells and plants containing said nucleic acid molecules as well as starch obtainable from the plants described are described. Furthermore, an in-vitro method for producing α-1,6-branched α-1,4-glucans on the basis of... Agent: Birch Stewart Kolasch & Birch

20080020426 - Novel glucose dehydrogenase: The present invention provides glucose dehydrogenase which is excellent in heat resistance and substrate specificity and is not affected by dissolved oxygen. Specifically, the present invention relates to glucose dehydrogenase characterized by being derived from an eukaryotic organism and keeping 90% or more activity after being treated with heat at... Agent: Leydig Voit & Mayer, Ltd

20080020425 - Polypeptides having lipase activity and polynucleotides encoding same: The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.... Agent: Novozymes, Inc.

20080020429 - Method for producing alpha-1, 6-branched alpha-1, 4-glucans from sucrose: Nucleic acid molecules which encode a branching enzyme from a bacterium of the genus Neisseria, vectors, host cell, plant cells and plants containing said nucleic acid molecules as well as starch obtainable from the plants described are described. Furthermore, an in-vitro method for producing α-1,6-branched α-1,4-glucans on the basis of... Agent: Birch Stewart Kolasch & Birch

20080020431 - Methods and kits for nucleic acid amplification: Compositions and methods are provided for amplifying nucleic acid molecules. The nucleic acid molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays.... Agent: J. Gary Mohr (datascope)

20080020432 - Method for producing alpha-1, 6-branched alpha-1, 4-glucans from sucrose: Nucleic acid molecules which encode a branching enzyme from a bacterium of the genus Neisseria, vectors, host cell, plant cells and plants containing said nucleic acid molecules as well as starch obtainable from the plants described are described. Furthermore, an in-vitro method for producing α-1,6-branched α-1,4-glucans on the basis of... Agent: Birch Stewart Kolasch & Birch

20080020433 - Process for producing amino acids: The present invention provides a microorganism obtainable by introducing a DNA coding for NADH dehydrogenase constituting a NADH dehydrogenase complex whose number of dischargeable proton molecules per electron is zero among NADH dehydrogenase complexes functioning as a proton pump in electron transport systems of aerobic bacteria, and an industrially advantageous... Agent: Fitzpatrick Cella Harper & Scinto

20080020434 - Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors: Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways,... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080020435 - Aldolases, nucleic acids encoding them and methods for making and using them: This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20080020436 - Novel gene encoding formate dehydrogenases d & e and method for preparing succinic acid using the same: Nucleotide sequences encoding formate dehydrogenases D & E and a method for preparing succinic acid using the same, more particularly, formate dehydrogenases D & E converting formate to carbon dioxide and hydrogen, fdhD and fdhE nucleotide sequences encoding the formate dehydrogenases D & E, recombinant vectors containing the nucleotide sequences,... Agent: Intellectual Property / Technology Law

20080020437 - Apparatus and method for producing fuel ethanol from biomass: Cellulosic biomass at the growing site is pulverized and hydrolyzed in collectors which transfer the comminuted biomass into pretreatment units. In the pretreatment units enzymes and/or other agents are added to the pretreatment units to disassociate the lignin from the cellulose and hemicellulose, and to further decompose the biomass to... Agent: Dann, Dorfman, Herrell & Skillman

20080020438 - Diterpene-producing unicellular organism: The present invention is directed to a unicellular organism system, such as a yeast, for producing geranylgeranyl pyrophosphate and a diterpene in vivo. The yeast cell preferably comprises an inducible nucleic acid sequence encoding geranylgeranyl pyrophosphate synthase, an inducible nucleic acid sequence encoding a soluble form of HMG-CoA reductase, a... Agent: Baker Botts L.L.P. Patent Department

20080020439 - Enzymes as corrosion inhibitors by removal of oxygen dissolved in water: The invention relates to a new process for water de-oxygenation, for application in aerosol products. The process involves the use of an enzymatic system based on an oxidase enzyme a substrate for the oxidase enzyme and catalase. These two enzymes consume oxygen by a two step reaction with the substrate... Agent: Norris, Mclaughlin & Marcus

20080020440 - Method of sequestering and/or purifying a polypeptide: The present invention relates to DNA and polypeptide constructs and related methods useful for sequestering and/or purifying polypeptides. In particular, the invention relates to hybrid polypeptides comprising a polypeptide of interest linked to a polymerisable polypeptide, a method of sequestering and/or purifying a polypeptide of interest using the hybrid polypeptide... Agent: Protigene Pty Ltd

20080020441 - Intact minicells as vectors for dna transfer and gene therapy invitro and invivo: A composition comprising recombinant, intact minicells that contain a therapeutic nucleic acid molecule is disclosed. Methods for purifying a preparation of such minicells also are disclosed. Additionally, a genetic transformation method is disclosed, which comprises (i) making recombinant, intact minicells available that contain a plasmid comprised of a first nucleic... Agent: Foley And Lardner LLP Suite 500

20080020442 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080020444 - Methyltransferase genes and uses thereof: The present invention relates to genes associated with the tocopherol biosynthesis pathway. More particularly, the present invention provides and includes nucleic acid molecules, proteins, and antibodies associated with genes that encode polypeptides that have methyltransferase activity. The present invention also provides methods for utilizing such agents, for example in gene... Agent: Sonnenschein Nath & Rosenthal LLP

20080020443 - Simultaneous cloning of genes and expression of recombinant proteins in escherichia coli: The mutation of the endA and recA genes in E. coli strain BL21 creates features that are very attractive for protein expression and cloning in a single prokaryotic system, including rapid cell growth, high transformation efficiency, rapid plasmid replication to high densities, and high plasmid stability. When specially prepared for... Agent: Banner & Witcoff, Ltd.

20080020445 - Selective growth medium for listeria spp: Disclosed is a growth medium containing nitrofurantoin. The growth medium is selective for the growth of Listeria spp.... Agent: Dewitt Ross & Stevens S.c.

20080020446 - Plasmid dna isolation: The invention provides apparatus, reagents, and methods for rapidly isolating plasmid DNA from a bacterial alkaline lysate.... Agent: Jonathan Claypool

20080020447 - Method for anaerobic degradation of fuel oxygenates and similar compounds: The present invention relates to a method for remediating fuel oxygenate-contaminated soil, sediment or groundwater comprising combining at least one natural microorganism source with at least one methoxylated phenolic compound under anaerobic conditions. The invention also relates to a method for increasing the rate of remediation of fuel oxygenate-contaminated soil.... Agent: Synnestvedt & Lechner, LLP

20080020448 - Surfactant biocatalyst for remediation of recalcitrant organics and heavy metals: Novel strains of isolated and purified bacteria have been identified which have the ability to degrade petroleum hydrocarbons including a variety of PAHs. Several isolates also exhibit the ability to produce a biosurfactant. The combination of the biosurfactant-producing ability along with the ability to degrade PAHs enhances the efficiency with... Agent: J. Bennett Mullinax, LLC

20080020449 - Method for separating bast fibers: A pressing step for pressing a bast is provided prior to a step for immersing the bast in an aqueous solution to decompose a gum existing in the bast and bonding bast fibers to each other. The bast fibers and the gum of the bast are mechanically separated from each... Agent: Patterson, Thuente, Skaar & Christensen, P.A.

20080020450 - Apparatus for electrophoretic in situ tissue staining: The present invention introduces a radically different way of accelerating biomolecule conjugates into tissue, and hence towards their targets for purposes of tissue staining. The invention provides for an order of magnitude improvement over the prior art diffusion process used to stain tissue. The invention comprises a method of tissue... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20080020451 - Material sucking or discharging apparatus and method: An apparatus includes a perforated member that has a pore used to discharge or suck a material, a cleansing unit that irradiates a plasma activated cleansing gas to the perforated member, and a moving unit that moves at least one of the perforated member and the cleansing unit.... Agent: Staas & Halsey LLP

20080020452 - Diagnostic strip coding system with conductive layers: A diagnostic test strip is provided. The test strip comprises at least one electrically insulating substrate material and a plurality of electrical strip contacts disposed on the least one insulating substrate layer. The at least one electrical strip contact includes a first conductive layer disposed on the substrate, and a... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080020453 - Analytical system based on porous material for highly parallel single cell detection: At least one embodiment of the present invention relates to analytical systems based on porous material, for example silicon, for highly parallel single cell detection. At least one embodiment of the present invention relates in particular to porous silicon having a multiplicity of continuous channels and/or to the use thereof... Agent: Harness, Dickey & Pierce, P.L.C

20080020454 - Optical glucose sensor chip and method of manufacturing the same: An optical glucose sensor chip includes a substrate, a pair of optical elements formed on a surface of the substrate for introducing light into the substrate and for emitting the light from the substrate, and a glucose sensing membrane formed on the surface of the substrate at a position between... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080020455 - Specimen carrier for the study of cell growth: The invention relates to a specimen carrier for the study of cell growth, comprising a substrate with a reservoir with a bottom, wherein the reservoir is filled up to a predetermined height of the side wall, which is smaller than the complete height of the reservoir, with a carrier material... Agent: Ip Strategies

20080020456 - Systems and methods for converting organic waste materials into useful products: Systems and methods are provided for converting organic waste materials from a municipal waste stream to useful products. Organic waste materials having a wide range of compositions such as, for example, yard waste, food waste, paper, and the organic fraction of municipal solid waste are converted into a uniform biomass... Agent: Carr & Ferrell LLP

20080020457 - Neoplasm specific antibodies and uses thereof: The present invention features polypeptides, such as antibodies, and their use in the treatment and diagnosis of neoplasms.... Agent: Pillsbury Winthrop Shaw Pittman LLP

20080020458 - Culture system for rapid expansion of human embryonic stem cells: This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described here, the role of feeder cells is replaced by components added to... Agent: Geron Corporation

20080020459 - Progenitor cell populations, expansion thereof, and growth of non-hematopoietic cell types and tissues therefrom: Described is a method of expanding human progenitor cells by suspension culturing under non-static conditions. The culturing method provides a three-dimensional space for the rapid expansion of desirable progenitors. By this method, a new compartment of multipotential progenitor cells has been identified, which give rise under differentiation conditions to progeny... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080020460 - Method for storing melanocytes as a suspension: The present invention is related to a method for storing melanocytes. The melanocytes suspension of the present invention can be stored at a temperature range from 4° C. to 22.5° C., wherein the storage temperature for baby melanocytes suspension ranges from 4° C. to 15° C. The viability of the... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20080020462 - Atm kinase compositions and methods: The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation state of Ataxia Telangiectasia-Mutated (ATM) kinase. Methods of identifying agents which modulate the activation and activity of ATM kinase are also provided.... Agent: St. Jude Children''s Research Hospital C/o Darby & Darby P.C.

20080020463 - Entrapped stem cells and uses thereof: The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal... Agent: Fulbright & Jaworski, LLP

20080020461 - Kinesin-like proteins and methods of use: The invention relates to methods and compounds for treating subjects who have proliferative disorders. The invention also relates to screening methods for identifying such compounds. The methods and compositions target the activity of the human kinesin-like protein KIF18A (and the KIF18A ortholog, KLP67A) and homologs thereof, and a gene encoding... Agent: Fish & Richardson PC

20080020464 - Vascular plants expressing na+ pumping atpases: The present invention relates to a vascular plant including cells expressing a Na+ pumping ATPase.... Agent: Birch Stewart Kolasch & Birch

20080020465 - Site-specific serine recombinases and methods of their use: The present invention provides a method for obtaining site-specific recombination in a eukaryotic cell, the method comprising providing a eukaryotic cell that comprises a first recombination attachment site and a second recombination attachment site; contacting the first and second recombination attachment sites with a prokaryotic recombinase polypeptide, resulting in recombination... Agent: Sughrue Mion, PLLC

  
01/17/2008 > patent applications in patent subcategories. USPTO class listing

20080014571 - Cell analysis apparatus and method: Devices and methods that measure one or more properties of a living cell culture that is contained in liquid media within a vessel, and typically analyzes plural cell cultures contained in plural vessels such as the wells of a multiwell microplate substantially in parallel. The devices incorporate a sensor that... Agent: Goodwin Procter LLP Patent Administrator

20080014572 - Methods and systems for molecular inhibition: Methods and systems are described which identify the structure of a biochemical or pathogenic molecule as well as at least one interacting molecule structure. These structures may be predicted to form at least one complex. In some embodiments, the stability and toxicity of at least one molecule structure and/or complex... Agent: Searete LLC Clarence T. Tegreene

20080014574 - Photo-acoustic detection device and method: An example method for detecting an analyte in a sample of a bodily fluid comprises the steps of exposing the bodily fluid sample to electromagnetic energy to cause a thermoelastic expansion in the analyte, and detecting a photoacoustic signal in the sample that results from the thermoelastic expansion.... Agent: Greer, Burns & Crain

20080014581 - Biosensor element and method for manufacturing the same: A biosensor is formed by immobilizing metal particles immobilized on a surface of a carrier and immobilizing probe molecules which are modified with fluorescent molecules on the metal particles. A biomolecule is detected at high sensitivity by use of this biosensor and utilizing fluorescence-quenching and fluorescence-enhancement effects attributable to the... Agent: Antonelli, Terry, Stout & Kraus, LLP

20080014580 - Detection of biological molecules using thz absorption spectroscopy: A method and apparatus of detecting biological molecules, the method including the steps of: performing Terahertz (THz) absorption spectroscopy, performed in a first frequency range of 0.2 to 2.2 THz (10-79.2 cm−1), on at least one sample including a substance comprising the biological molecules, the substance being selected from at... Agent: Dilworth & Barrese, LLP

20080014579 - Gene expression profiling in colon cancers: Sets of genetic markers for specific tumor classes are described, as well as methods of identifying a biological sample based on these markers. Genes that are differentially expressed between different stages of colorectal tumors are identified. Genes that are differentially expressed between tumors that have metastasized to the regional lymph... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20080014578 - Method of multiplex microorganism detection: The present invention is to provide a multiple detection method that can detect contaminating microorganisms existing in foods, including pathogenic Escherichia coli O157, Listeria monocytogenes and Salmonella spp., with high sensitivity comparable or even superior to official methods, comprising the steps of amplifying a... Agent: Morgan & Finnegan, L.L.P.

20080014583 - Methods for identifying candidate fat-mobilizing agents: Disclosed herein are methods for identifying agents capable of affecting the expression, posttranslational modification, and/or an activity of TRB3, for example, in adipose tissue and/or adipocytes. Such agents are useful, for example, to mobilize fat stores and as prospective obesity therapeutics.... Agent: Klarquist Sparkman, LLP

20080014594 - Lung-expressed polypeptides: Modulators of phosphatidic acid phosphatase type 2C and other polypeptides, highly expressed in cancers as compared to normal tissues, are provided for treatment of proliferative disorders such as cancer. A method is provided for detecting polypeptides that are overexpressed in cancer, whereby antibodies or binding proteins that specifically recognize these... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080014596 - Addl binding to hippocampal neurons: Disclosed herein are methods for the quantification of ADDL binding to neuronal cells, including, but not limited to, primary cultures of hippocampal neurons. The method identifies and selects neurons based on any means capable of distinguishing neuronal cells, including, but not limited to, MAP2 immunoreactivity, which ensures that glial cells... Agent: Jane Massey Licata, Esquire Licata & Tyrrell P.C.

20080014599 - Screening systems utilizing rtp801l: s

20080014598 - Phospho-specific antibodies to pi3k regulatory subunit and uses thereof: The invention discloses ten newly discovered PI3K regulatory subunit phosphorylation sites, tyrosines 467, 452, 463, and 470 in PI3KR1 (PI3Kp85 alpha), tyrosines 464, 460, and 467 in PI3KR2 (PI3Kp85 beta), and tyrosines 199, 184, and 202 in PI3KR3 (PI3Kp55 gamma), and provides reagents, including polyclonal and monoclonal antibodies, that selectively... Agent: Simona Levi-minzi, Ph.d. General Counsel

20080014601 - Controller for a blood parameter testing system and method of testing therefor: The present invention is directed toward a method of measuring a blood parameter and, in particular, a glucose measurement system controlled by a novel controller. In one embodiment, the system has a controller, a pump, flush solution in a first reservoir, IV solution in a second reservoir, a first valve,... Agent: Patentmetrix

20080014602 - Fluorescent probe: (wherein, R1 represents a monovalent substituent other than hydrogen atom, carboxy group, or sulfo group; R2 represents hydrogen atom, or a monovalent substituent; R3 and R4 each independently represents hydrogen atom or a halogen atom; and R5 represents a monovalent group which is cleaved by contact with a measuring object,... Agent: Greenblum & Bernstein, P.L.C

20080014603 - Linear high-throughput proteomics: A method of analyzing a sample comprising multiple protein species is provided. The proteins are separated by species such that the multiple protein species emerge in a sequential order and are then digested in the sequential order in which they emerge from the separation process. The digested proteins are introduced... Agent: Agilent Technologies Inc.

20080014609 - Methods for obtaining thermostable enzymes, dna polymerase i variants from thermus aquaticus having new catalytic activities, methods for obtaining the same, and applications to the same: A thermostable mutant DNA polymerase; a method for obtaining the thernmostable mutant DNA polymerase by identifying a thermostable mutant polypeptide exhibiting enzymatic activity, wherein the thermostable mutant polypeptide is a variant of DNA polymerase I obtained from Thermus aquaticus; a polynucleotide, an expression vector, and a host cell encoding the... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080014608 - Modified promoter: A promoter DNA recognized by SigA and SigE, which is produced by modifying a nucleotide sequence including a promoter recognized by SigA and bases in the vicinity thereof; an expression vector harboring the promoter DNA; a recombinant microorganism containing the expression vector; and a method for producing proteins or polypeptides... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080014570 - Method of removing adhesive microvesicles: A method for selectively measuring microvesicles alone in blood by pretreating a sample derived from blood with albumin to selectively eliminate microvesicles alone released from platelets activated by an artificial manipulation.... Agent: Sughrue Mion, PLLC

20080014573 - Biosample manipulation apparatus: A biosample manipulation method according to the invention includes the steps of: providing a scanning probe microscope (3) with a cantilever (9) including a beam portion (15) with its base end supported in a cantilever manner, a probe (17) formed to protrude from the beam portion (15) and having a... Agent: Kratz, Quintos & Hanson, LLP

20080014576 - Microfluidic devices: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.... Agent: Wilson Sonsini Goodrich & Rosati

20080014577 - Oncolytic viruses as phenotyping agents for neoplasms: The present invention provides a method of diagnosing neoplasms having a particular phenotype by using oncolytic viruses that selectively replicate in neoplasms having the particular phenotype. For example, reovirus does not replicate in normal cells. However, reovirus selectively replicate in cells with an activated ras pathway, which leads to death... Agent: Fish & Richardson P.C.

20080014575 - Rapid microfluidic assay for quantitative measurement of interactions among one or more analytes: The invention provides microfluidic competitive immunoassay devices and assay methods for rapid, quantitative measurement of binding interactions between analytes and the quantitative determination of an amount (e.g., concentration) of the analyte in an unknown sample.... Agent: Karen S. Canady Canady & Lortz LLP

20080014591 - Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres: The present invention is directed to processes of separating, analyzing and/or collecting selected species within a target sample by use of magnetic microspheres including magnetic particles, the magnetic microspheres adapted for attachment to a receptor agent that can subsequently bind to selected species within the target sample. The magnetic microspheres... Agent: Los Alamos National Security, LLC

20080014588 - Compositions and methods for detecting multidrug resistant strains of m. tuberculosis having mutations in genes of the mutt family: The present invention pertains to polynucleotides derived from M. tuberculosis genes imparting resistance to antibiotics and chemically related compounds. This invention also relates to the use of the polynucleotides as oligonucleotide primers or probes for detecting M. tuberculosis strains that are resistant to antibiotics and related compounds in a biological... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080014586 - Identification of a receptor controlling migration and metastasis of skin cancer cells: The invention relates generally to genes expressed in skin cancer cells, particularly melanoma tumor cells, and their role in migration and metastasis. Methods for identifying melanoma cells are provided, as are methods of treating melanoma. Methods for identifying compounds that are useful in the treatment of melanoma are also provided.... Agent: Knobbe Martens Olson & Bear LLP

20080014582 - Methods and compositions for detecting fungi and mycotoxins: The invention relates to a method of identifying a specific fungal species in patient tissue or body fluid. The method comprises the steps of extracting and recovering DNA of the fungal species from the patient tissue or body fluid, amplifying the DNA, hybridizing a probe to the DNA to specifically... Agent: Barnes & Thornburg LLP

20080014589 - Microfluidic devices and methods of use thereof: The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20080014584 - Modulating androgen receptor activity: This document relates to methods and materials involved in modulating (e.g., inhibiting or stimulating) the activity of an androgen receptor polypeptide. For example, this document provides materials and methods involved in identifying molecules that interact with and inhibit the activity of an androgen receptor polypeptide in androgen-independent prostate cancer cells.... Agent: Fish & Richardson P.C.

20080014593 - Novel human g-protein coupled receptor, hgprbmy23, expressed highly in kidney: The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention... Agent: Louis J. Wille Bristol-myers Squibb Company

20080014590 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of prostate cancer: Novel markers for prostate cancer that are both sensitive and accurate. Furthermore, these markers are able to distinguish between prostate cancer and benign prostate hyperplasia (“BPH”). These markers are overexpressed in prostate cancer specifically, as opposed to normal prostate tissue and/or BPH. The measurement of these markers, alone or in... Agent: Staas & Halsey LLP

20080014592 - Nucleic acid sequence analysis: The present invention relates to a method for determining the sequence of a polynucleotide, the method comprising the steps of: (i) reacting a target polynucleotide with a polymerase enzyme immobilized on a solid support, and the different nucleotides, under conditions sufficient for the polymerase reaction; and (ii) detecting the incorporation... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080014587 - Polynucleotides for use as tags and tag complements, manufacture and use thereof: A family of minimally cross-hybridizing nucleotide sequences, methods of use, etc. A specific family of 210 24mers is described.... Agent: Goodwin Procter LLP Patent Administrator

20080014585 - Synergistic activation of regulatory elements by rel proteins and a steroid receptor: Interaction of Rel proteins and steroid receptors is known to result in repression of target genes. Here we describe the discovery of a new mechanism in which Rel proteins and steroid receptors act synergistically to activate a regulatory element. This mechanism is shown to influence the expression of the brain-specific... Agent: Organon Usa, Inc. Patent Department

20080014595 - Detection of glutathionylated proteins: The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as S-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having... Agent: Wolf Greenfield & Sacks, P.C.

20080014597 - Phosphorylated p68 rna helicase as a marker for cancer and cancer metastasis: A method for determining the presence of cancer cells in a tissue sample or cell sample by detecting the presence of phosphorylated p68 RNA helicase in the sample. Further, a method for determining the presence of metastatic cancer cells in a tissue sample or cell sample by detecting the level... Agent: Christpher B. Linder Thomas, Kayden, Horstemeyer & Risley, L.L.P.

20080014600 - Diagnosis of multiple sclerosis and other demyelinating diseases: A method of diagnosing multiple sclerosis and other demyelinating diseases or predicting a predisposition to multiple sclerosis and other demyelinating diseases. The method utilizes detection of increased amounts of memory lymphocytes reacting to MS antigens, proinflammatory cytokines, and antibodies against MS antigens.... Agent: Knobbe Martens Olson & Bear LLP

20080014604 - Method for the early detection of renal injury: A method and kit for detecting the immediate or early onset of renal disease and injury, including renal tubular cell injury, utilizing NGAL as an immediate or early on-set biomarker in a sample of blood serum. NGAL is a small secreted polypeptide that is protease resistant and consequently readily detected... Agent: Hasse & Nesbitt LLC

20080014605 - Method and apparatus for selectively targeting specific cells within a cell population: This invention provides a method and apparatus for selectively identifying, and targeting with an energy beam, specific cells within a cell population, for the purpose of inducing a response in the targeted cells. Using the present invention, every detectable cell in a population can be identified and affected, without substantially... Agent: Knobbe Martens Olson & Bear LLP

20080014606 - Methods for purification of cells based on product secretion: The invention provides methods for purifying one or more cells based on the level of one or more products secreted by the cells. In one embodiment, the method involves (a) contacting a plurality of cells immobilized in proximity to a capture matrix, the capture matrix capable of localizing a product... Agent: Knobbe Martens Olson & Bear LLP

20080014607 - Atp-metry based on intracellular adenyl nucleotides for detecting and counting cells, use and implementing method for determining bacteria in particular devoid of atp: The invention concerns the use of bioluminescence dependent on the reaction (1): luciferin+ATP+O2+Mg2++luciferase→oxyluciferin+photons for detecting and counting living cells of a given species potentially present in a liquid sample, said use being characterized in that it consists in measuring the total free intracellular adenyl nucleotides (AN) content, expressed in ATP... Agent: Foley & Lardner LLP

20080014610 - Container for nucleic acid extraction, method of cleaning solid matrix and relevant cleaning mechanism, and method of purifying nucleic acid: The present invention relates to a nucleic acid extraction container (2) which includes a nucleic acid extraction element (20) for extracting a target nucleic acid from a sample and supporting the extracted nucleic acid, and a container main body formed as a separate member from the nucleic acid extraction element... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20080014614 - Labeling of rapamycin using rapamycin-specific methylases: A method for rapamycin-specific labeling using rapI, rapM and/or rapQ enzymes is described. Also are methods for generating crude enzyme extracts useful in the method of the invention. Uses of the specifically labeled rapamycin as diagnostic tools are provided.... Agent: Howson And Howson/wyeth Cathy A. Kodroff

20080014611 - Method for highly expressing recombinant glucose dehydrogenase derived from filamentous bacterium: The present invention provides a method for highly expressing a recombinant FAD-GDH protein derived from filamentous fungi, protein obtained by the method, and a regent for measuring glucose using the protein. According to the invention, the FAD-GDH can be highly expressed by altering DNA sequence coding for a signal peptide... Agent: Leydig Voit & Mayer, Ltd

20080014612 - Method for producing glucose dehydrogenase from aspergillus oryzae: e

20080014613 - Prokaryotic collagen-like proteins and uses thereof: The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host... Agent: Benjamin Aaron Adler, Ph.d., J. D.

20080014615 - Instrument for heating and cooling: An instrument and method is provided that conveniently allows rapid amplification of nucleic acids. The instrument comprises in the following order at least one substantially flat temperature sensor element; a heat conducting substrate and a heater layer, whereby the heat conducting substrate comprises one or more channels permeable for fluid.... Agent: Townsend And Townsend And Crew, LLP

20080014616 - Methods of introducing targeted diversity into nucleic acid molecules: Systems are disclosed that are useful for introducing one or more targeted positions or regions of diversity into a nucleic acid molecule. In certain embodiments, diversity in a targeted position or region is generated by providing one or more degenerate primer sets and a template nucleic acid molecule, wherein the... Agent: Choate, Hall & Stewart LLP

20080014617 - Process and plant for the production of fermentable sugars from cellulose material: making the cellulose material and the reagent react in the thin layer while it advances in substantial contact with the inner wall of the turbo-reactor (A) towards the discharge opening (7), continuously discharging a flow of treated cellulose material, sending the flow of treated cellulose material to an enzymatic digestion... Agent: Lucas & Mercanti, LLP

20080014618 - Method of production of l-amino acids: An isolated polynucleotide encodes a polypeptide comprising the amino acid sequence of SEQ ID NO: 2, with the L-aspartic acid at position 5 of the amino acid sequence replaced by another proteinogenic amino acid, and possesses citrate synthase activity. In addition, a vector comprises the polynucleotide and a bacterium comprises... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080014619 - Method of production of para-hydroxycinnamic acid: Methods for the production of PHCA are disclosed. The methods rely on the tight gene expression of genetic constructs encoding polypeptides having tyrosine ammonia lyase activity. Promoters of choice are arabinose inducible.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20080014620 - Fermentation of pentose sugars: The present invention relates to host cells transformed with a nucleic acid sequence encoding a eukaryotic xylose isomerase obtainable from an anaerobic fungus. When expressed, the sequence encoding the xylose isomerase confers to the host cell the ability to convert xylose to xylulose which may be further metabolised... Agent: Mckenna Long & Aldridge LLP

20080014621 - Fabrication of metal nanoshells: Metal nanoshells are fabricated by admixing an aqueous solution of metal ions with an aqueous solution of apoferritin protein molecules, followed by admixing an aqueous solution containing an excess of an oxidizing agent for the metal ions. The apoferritin molecules serve as bio-templates for the formation of metal nanoshells, which... Agent: George F. Helfrich C/o Kaufman & Canoles

20080014622 - Devices, systems and methods for reducing the concentration of a chemical entity in fluids: A device for removal of at least a portion of carbon dioxide from an aqueous fluid includes at least one membrane through which carbon dioxide can pass to be removed from the fluid and immobilized carbonic anhydrase on or in the vicinity of a first surface of the membrane to... Agent: Bartony & Hare, LLP

20080014623 - Nutrient absorption enhancing compositions and methods: The present invention provides a nutrient absorption enhancing composition that contains a mixture of various Aspergillus derived enzymes and mineral cofactors. In one aspect, the enzymes of the formulation may include protease, lipase, amylase, and cellulase. In another aspect, the mineral cofactors of the formulation may include calcium compounds, zinc... Agent: Thorpe North & Western, LLP.

20080014624 - Flea peritrophin nucleic acid molecules: The present invention relates to flea peritrophin proteins; to flea peritrophin nucleic acid molecules, including those that encode such flea peritrophin proteins; to antibodies raised against such proteins; and to compounds that inhibit the activity of such proteins. The present invention also includes methods to obtain and use such proteins,... Agent: Heska Corporation Legal Department

20080014625 - Adsorptive membranes for trapping viruses: A disposable, virus-trapping membrane, and a corresponding method to remove viruses from solution are described. The membrane includes a disposable, micro-porous filter membrane and a ligand immobilized on the membrane. The ligand irreversibly and selectively binds viruses. The ligand also has a pKa sufficiently high to repel antibodies via electrostatic... Agent: Dewitt Ross & Stevens S.c. Wisconsin Alumni Research Foundation

20080014626 - Method for preparing viral material: The invention relates to a method for preparing viral suspensions. The invention relates in particular to a method for preparing high-titer viral suspensions in cell cultures. Preferred methods include increasing the volume of the cell culture prior to infection with viral material and subsequent further steps of expanding the volume... Agent: Morrison & Foerster LLP

20080014627 - Devices and methods for selectively lysing cells: A device for generating microbubbles in a gas and liquid mixture and injection device, the device comprising a housing defining a mixing chamber; means for mixing solution contained in the mixing chamber to generate microbubbles in the solution; and a needle array removably attached to the housing and in fluid... Agent: Fulwider Patton - Cabochon Aesthetics

20080014628 - Cell incubator for single cell operation supporting robot: [MEANS FOR SOLVING PROBREMS] First and second feature points (P1, P2) are formed on a film-like feature point setup chip (36) which is then stuck to the cell incubator body such as a conventional dish (35), thus constituting a cell incubator (34). Since manufacture of a new die for forming... Agent: Greenblum & Bernstein, P.L.C

20080014629 - Closure for milliliter scale bioreactor: A closure for a microreactor includes a cap that is configured to be inserted into a well of the microreactor. The cap, or at least a portion of the cap, is compliant so as to form a seal with the well when the cap is inserted. The cap includes an... Agent: Silicon Valley Patent Group LLP

20080014630 - Bioassay substrate and bioassay method: A bioassay substrate and method thereof is provide. In the bioassay substrate, a sample solution is dripped onto a spot area to which a plurality of detection substances is fixed and an interaction between the detection substance and a target substance in the sample solution is detected by fluorescent intensity.... Agent: Bell, Boyd & Lloyd, LLP

20080014631 - Microwell array chip and its manufacturing method: A microwell array chip having multiple microwells on a principal surface of a substrate, said microwells being of a shape and size permitting the storage of only a single organic cell in each microwell, wherein microwell markers are present on the same substrate surface as the openings of the microwells.... Agent: Birch Stewart Kolasch & Birch

20080014632 - Near ultraviolet-wavelength photonic-crystal biosensor with enhanced surface to bulk sensitivity ratio: Biosensors are disclosed based on one- or two-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous Coupled-Wave Analysis simulations predict a more tightly confined resonant electric field at the surface of this biosensor as compared to previously fabricated near-infrared photonic-crystal biosensors. This change in the resonant electric field provides an... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080014633 - Manipulation of plant senescence using modified promoters: The present invention relates to methods of manipulating senescence in plants. The invention also relates to vectors useful in such methods, transformed plants with modified senescence characteristics and plant cells, seeds and other parts of such plants.... Agent: Sheldon Mak Rose & Anderson PC

20080014635 - Methods of increasing protein expression levels: The present invention relates to methods of increasing protein expression levels whereby at least one amino acid in a protein amino acid sequence is substituted for the amino acid, proline. Preferably, the substitution occurs within 15 amino acids, more preferably within 10 amino acids and most preferably within 5 amino... Agent: Howrey LLP

20080014634 - Selective cloning of homoduplex nucleic acids: The subject invention provides for a method of selectively cloning homoduplex nucleic acid molecules, in particular, by using a strain of host cells that contains a conditionally expressed and/or conditionally active mismatch-recognizing enzyme, e.g., a temperature sensitive variant of the gene encoding the endonuclease VII from phage T4. Using this... Agent: Agilent Techologies Inc

20080014636 - Tumor antigen protein and use thereof: An inducer of cytotoxic T cells comprising as an active ingredient a protein which comprises the same or substantially the same amino acid sequence as that shown in SEQ ID NO: 2, or a peptide derived from the protein above is provided.... Agent: Birch Stewart Kolasch & Birch

20080014637 - Process for culturing cells sampled for biopsy: The present invention provide: a novel process for culturing animal cells and a kit for culturing animal cells, in which, even if the number of cells as sampled for biopsy is extremely small, the proliferation can sufficiently be maintained so as to enable to carry out various culture and/or tests,... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20080014638 - Culture medium containing kinase inhibitors, and uses thereof: Pluripotent cells are maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and, optionally, an antagonist of an FGF receptor. Pluripotent cells are also maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor and an antagonist of an FGF... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

  
01/10/2008 > patent applications in patent subcategories. USPTO class listing

20080008988 - Compositions and methods for diagnosis of axial pain with or without radiculopathy: The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20080008994 - Peptide nucleic acid probes for analysis of certain staphylococcus species: The present invention relates to peptide nucleic acid (PNA) probes, PNA probe sets and methods for the analysis of certain Staphylococcus species optionally present in a sample. The invention further relates to diagnostic kits comprising such PNA probes or PNA probe sets.... Agent: Edwards Angell Palmer & Dodge LLP

20080009024 - Methods for identifying patients with increased risk of an adverse cardiovascular event: Methods, compositions and kits are disclosed for identifying patients with an increased risk of experiencing an adverse cardiovascular event where the patient is undergoing aspirin antiplatelet therapy. A platelet-containing sample from the patient is evaluated for platelet hyperactivity and platelet hyperactivity in the sample is related to the patient's risk... Agent: Dade Behring Inc. Legal Department

20080009026 - Fluorogenic protein kinase substrates: The present invention relates to kinase sensors comprising a metal chelator and a fluorophore, where the chelator comprises a quinoline group and where the fluorophore is conjugated to the chelator. The invention also relates to methods of using these kinase sensors as well as kits comprising the kinase sensors.... Agent: Invitrogen Corporation C/o Intellevate

20080009036 - Method for cloning and expression of acc65i restriction endonuclease and acc65i methylase in e. coli: An isolated DNA is provided which encodes a protein that is capable of binding to 5′GGTACC-3′, the isolated DNA being capable of hybridizing to SEQ ID NO:3 under stringent hybridization conditions. The isolated DNA may be alternatively characterized as coding for a protein having an amino acid sequence comprising SEQ... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20080009032 - Method for producing yellow flower by controlling flavonoid synthetic pathway: There is provided a gene coding for the amino acid sequence listed as SEQ ID NO: 2 or SEQ ID NO: 70, for example. Co-expression of the 4′CGT gene and AS gene in a plant lacking natural aurone synthesis ability is carried out to successfully accumulate aurones and alter the... Agent: Drinker Biddle & Reath (dc)

20080009038 - Methods for enhancing antibody activity: Anti-human Mp1 antibodies were isolated and purified, and then single-chain anti-human Mp1 antibodies were prepared using genetic engineering techniques. The antibodies were found to exhibit a high agonistic activity. This shows that the activity of an antibody can be enhanced by making the antibody into a single-chain... Agent: Fish & Richardson PC

20080009039 - Recombinant microorganism: A recombinant microorganism obtained by transferring, into a host microorganism capable of producing protein or polypeptide with increased productivity, a gene encoding a protein or polypeptide, and a method for producing a protein or polypeptide by use of the recombinant microorganism. The recombinant microorganism is prepared by transferring, to a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080009043 - Microfluidic device including a microchannel with a hydrophobic porous polymer bonded to walls thereof and to a magnetic bead, and methods of making and using the device: This invention provides a microfluidic device comprising an inlet and an outlet which are connected with each other through a microchannel, wherein a polymerized hydrophobic porous polymer is bonded to magnetic beads and to the walls of the microchannel. The invention is further directed to methods of making and using... Agent: Cantor Colburn, LLP

20080008987 - Laparoscopic kidney cooling device: The present invention encompasses a device for changing the temperature of the kidney during laparoscopic surgery or during organ transportation or transplantation.... Agent: Bell & Associates

20080008989 - Diagnostic tape cassette: A diagnostic tape cassette especially for blood sugar tests comprises a test tape which is provided with a plurality of test fields for analysing body fluid, and a housing for receiving the test tape. The housing may have at least one housing part formed from a metal support and moulded-on... Agent: Baker & Daniels LLP / Roche

20080008992 - Method of pretreating specimen and immunoassay using the same: The present invention provides a method of pretreating a specimen, which allows measurement according to an immunoassay to be carried out on a specimen from nasal secretion while preventing non-specific reactions. According to this method, the specimen from nasal secretion is treated with a protease beforehand and then an immunoassay... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20080008990 - One step diagnosis by dna chip: This invention relates to chips containing nucleic acid probes or primers and their use in methods to detect nucleic acid molecules. The invention includes DNA chips in contact with a thermocycler capable of automatically regulating the temperature, temperature cycle times, and number of temperature cycles of the chips to provide... Agent: Patentique PLLC

20080008991 - System and method for optimizing drug therapy for the treatment of diseases: The present invention concerns the optimization of hiv-1 therapy using the combination of a bioanalytical method, population pharmacokinetic models and phenotypic resistance testing.... Agent: Johnson & Johnson

20080009002 - Analyte identification using electronic devices: The disclosure provided herein describes methods and devices for the detection of analytes and/or the characterization of interactions between analytes and compositions capable of binding the analytes. Embodiments of the invention allow the identification and/or characterization of analytes by monitoring the electronic properties of sensors having electronic circuits coupled to... Agent: Gates & Cooper LLP Howard Hughes Center

20080009004 - Claudin polypeptides, polynucleotides, and methods of making and use thereof: This invention relates to new members of the human Claudin polypeptide family, to methods of making such polypeptides, and to methods of using them to treat Claudin-associated conditions and to identify agents that alter Claudin polypeptide activities.... Agent: Immunex Corporation Law Department

20080009000 - Combinatorial decoding of random nucleic acid arrays: The invention provides methods and compositions for combinatorially decoding arrays.... Agent: Knobbe Martens Olson & Bear LLP

20080009008 - Composition and method for treating lupus nephritis: The present invention provides novel isolated BFLP1698 polynucleotides and polypeptides encoded by the BFLP1698 polynucleotides. Also provided are the antibodies that immunospecifically bind to a BFLP1698 polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the BFLP1698 polypeptide, polynucleotide or antibody. The invention additionally provides methods in... Agent: Wyeth Patent Law Group

20080008995 - Compositions and methods for the detection of a nucleic acid using a cleavage reaction: The invention relates to a method of generating a signal indicative of the presence of a target nucleic acid sequence in a sample, where the method includes forming a cleavage structure by incubating a sample containing a target nucleic acid sequence with a nucleic acid polymerase and cleaving the cleavage... Agent: Agilent Techologies Inc

20080009007 - Controlled initiation of primer extension: Controlled initiation of primer extension in determination of nucleic acid sequence information by incorporation of nucleotides or nucleotide analogs. Preferred aspects include photo-initiated extension through the use of photo-cleavable blocking, groups on termini of primer sequences followed by non-terminating primer extension using nucleotides or nucleotide analogs that are not extension... Agent: Morgan, Lewis & Bockius LLP (sf)

20080009005 - Detection of cancer by elevated levels of bcl-2: The present invention relates to a method for the diagnosis, prognosis, and monitoring of cancer, such as early or late stage ovarian cancer, in a subject by detecting Bcl-2 in a biological sample from the subject, preferably a urine or blood sample. Bcl-2 may be measured using an agent that... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080009009 - Device and method for high-throughput quantification of mrna from whole blood: Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to oligo(dT)-immobilized multi-well plates.... Agent: Knobbe Martens Olson & Bear LLP

20080009006 - Expression cloning in filamentous fungi: Methods are provided for isolation of DNA sequences encoding proteins with properties of interest by means of expression cloning in filamentous fungal host cells. The isolated DNA sequences are useful in processes for producing the proteins of interest.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080009013 - Method and device for identifying a polymer sequence: The invention relates to a method for identifying a first polymer sequence bound to a first phase that reflects electromagnetic waves. The inventive method includes the following steps: a) bringing the first polymer sequence into contact with an affine second polymer sequence, which is directly or indirectly bound, via metallic... Agent: Fish & Richardson P.C.

20080009011 - Method for determining the specific growth rate of distinct microbial populations in a non-homogeneous system: The present invention pertains to a molecular biology-based method and kit for measuring the specific growth rate (or cell doubling time) of distinct microbial populations. The method and kit can be used to analyze mixed culture samples that have been exposed to chloramphenicol or other protein synthesis inhibitors for defined... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080009001 - Method for identification of neoplastic transformation with particular reference to prostate cancer: A method used to design a microchip (DNA microarray) for identifying the presence of prostate tumor, evaluating its degree of mali-gnity (typization, characterization) and supplying information allowing prediction of the clinical course of the illness (prognosis) is discussed below. The method is based on assessment of the levels of expression... Agent: Jacobson Holman PLLC

20080008998 - Method for the detection of fusarium graminearum: A method for the detection of Fusarium graminearum (Gibberella zeae) comprising the steps: providing a sample containing a nucleic acid, contacting said sample with at least one forward primer and at least one reverse primer, wherein the at least one reverse primer hybridises within the β-tubulin nucleic acid sequence of... Agent: Fulbright & Jaworski L.L.P.

20080009010 - Methods for diagnosis and prognosis of psychotic disorders: The invention features methods diagnostic of a psychotic disorder such as bipolar disorder or schizophrenia. The methods include obtaining a cell sample from a subject, subjecting a cell from the sample to stress (e.g., nutrient stress), and measuring nucleic acid or polypeptide expression in the cell, where an alteration in... Agent: Clark & Elbing LLP

20080009012 - Methods, libraries and computer program products for determining whether sirna induced phenotypes are due to off-target effects: The present disclosure provides methods, libraries and computer program products for determining whether a phenotype induced by a candidate siRNA for a target gene in an RNAi experiment is target specific or a false positive. Through the use of a control siRNA that has one or two seed sequences of... Agent: Kalow & Springut LLP

20080008996 - Nucleic acid molecules and other molecules associated with plants: The present invention is in the field of plant genetics. More specifically the invention relates to nucleic acid molecules and nucleic acid molecules that contain markers, in particular, single nucleotide polymorphism (SNP) and repetitive element markers. In addition, the present invention provides nucleic acid molecules having regulatory elements or encoding... Agent: Arnold & Porter, LLP

20080008999 - Process for detecting the existence of mesenchymal chrondrosarcoma: A process for detecting Mesenchymal Chondrosarcoma in a biological organism, comprising detecting, in a sample that contains Mesenchymal Chondrosarcoma cells obtained from a subject a first product indicative of elevated expression of a fibroblast growth factor receptor gene or a second product indicative of elevated amounts of a fibroblast growth... Agent: Howard J. Greenwald P.C.

20080008997 - Proximity ligation assays with peptide conjugate 'burrs' and aptamers for the sensitive detection of spores and cancer cells: The present invention includes compositions and methods for the detection of specific targets on a surface that includes one or more peptides and one or more oligonucleotides connected by a joint to a detectable marker, wherein the joint between the peptides, the oligonucleotides or both the peptides and oligonucleotides are... Agent: Chalker Flores, LLP

20080009014 - Receptor activator of nf-kappab: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.... Agent: Immunex Corporation Law Department

20080009003 - Single promoter inhibitor: A method of identifying complementary DNA (cDNA) that contributes to cell phenotype includes providing a plurality of cells. The cells are effected so that each cell expresses a single ectopic cDNA. The cells are propagated for a growth interval in an environment that allows the cells to compete against one... Agent: Tarolli, Sundheim, Covell& Tummino L.L.P.

20080008993 - Use of a type iii restriction enzyme to isolate identification tags comprising more than 25 nucleotides: The type III restriction enzyme EcoP15I is used to isolate from cDNA of an expressed gene a tag comprising more than 25 nucleotides and capable of identifying the expressed gene, wherein the 3′ end of the tag is defined by a cleavage site of the type III restriction enzyme and... Agent: Birch Stewart Kolasch & Birch

20080009018 - Immunoassays for topiramate: Topiramate analogs have substituents at the sulfamate group, 9-position, or 10-position. Topiramate analogs may include immunogenic moieties to prepare anti-topiramate antibodies, or antigenic moieties for immunodiagnostic assays. Also, the topiramate analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the... Agent: Workman Nydegger

20080009015 - Methods for producing olfactory gpcrs: The subject invention provides a method for producing an olfactory GPCR in a cell. In general, the methods involve introducing an expression cassette containing a promoter operably linked to a nucleic acid encoding an olfactory PCR into a macroglial cell, e.g., a Schwann or oligodendritic cell, and maintaining the cell... Agent: Bozicevic, Field & Francis LLP (arena Pharmaceuticals, Inc.)

20080009016 - Novel monkey gpr103 and monkey qrfp and method of evaluating compound by using gpr103: There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for functional analysis of the GPR103 genes and proteins and for the compound evaluation. The nucleic acids or proteins having the... Agent: Merck And Co., Inc

20080009017 - Optoelectronic detection system: The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir containing cells, each of the cells having receptors which are present on the surface of each cell and are specific for the... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080009019 - High throughput method for screening candidate compounds for biological activity: A method for screening candidate compounds for an ability to modulate the biological activity of a target. The method includes the steps of providing a substrate comprising a target and an indicator, the substrate adapted for receiving a plurality of candidate compounds; contacting the substrate with a plurality of candidate... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B475

20080009022 - Immunization of dairy cattle with chimeric gapc protein against streptococcus infection: The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC... Agent: Robins & Pasternak

20080009020 - Myeloperoxidase, a risk indicator for cardiovascular disease: Diagnostic tests for characterizing an individual's risk of developing or having a cardiovascular disease. In one embodiment the present diagnostic test comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtained from the individual or test subject. In another embodiment, the diagnostic test comprises determining the level... Agent: Calfee Halter & Griswold, LLP

20080009021 - Assays for identifying ubiquitin agents and for identifying agents that modify the activity of ubiquitin agents: Provided are methods and compositions for assaying for ubiquitin agents that are enzymatic components of ubiquitin-mediated proteolysis and, more particularly, methods and compositions for assaying for agents that modulate the activity of such ubiquitin agents.... Agent: Townsend And Townsend And Crew, LLP

20080009023 - Diagnostic method for the forecasting of transplanted organ loosing: It is described a diagnostic method which allows to establish the risks of rejection of a transplanted organ by measuring the pre-transplant concentration of Mig in the serum of a patient to be submitted to transplantation.... Agent: Ohlandt, Greeley, Ruggiero & Perle, LLP

20080009025 - Protein kinase regulation: A method of identifying a compound that modulates the protein kinase activity of a protein kinase having a hydrophobic pocket in the position equivalent to the hydrophobic pocket of Protein Kinase A (PKA) that is defined by residues including Lys76, Leu116, Val80 and/or Lys111 of full-length mouse PKA, wherein the... Agent: Rogalsky & Weyand, LLP

20080009027 - Enhanced oxygen cell culture platforms: Provided is a cell culture apparatus for culturing cells, that provides enhanced oxygen delivery and supply to cells without the need for stirring or sparging. Oxygen diffusion occurs on both sides of the culture vessel, top and bottom. A gas-permeable membrane that includes perfluorocarbons in its composition allows for the... Agent: Akerman Senterfitt

20080009028 - Tissue embedding matrix: The invention is a matrix for preparing a tissue sample made of saline, albumin, gelatin, formaldehyde, a detergent, sucrose, lysine, and glutaraldehyde. The matrix is formed by first preparing a solution of saline, albumin, and gelatin, and then mixing the solution with formaldehyde, a detergent, and sucrose. Immediately prior to... Agent: Bond, Schoeneck & King, PLLC

20080009029 - Mass spectrometric measurement of microbial resistances: Microorganisms, particularly bacteria, are identified and characterized on the basis of a mass spectrometric measurement of their protein profiles with ionization by matrix-assisted laser desorption. In order to measure the microbial resistance to antibiotics, the protein profiles of microorganisms are measured after cultivation for a short time duration in nutrient... Agent: Law Offices Of Paul E. Kudirka

20080009030 - Methods for preventing or reducing ischemia/reperfusion induced myocardial cell death: Provided herein are methods relating to inhibition of PUMA function for preventing or reducing myocardial cell death. A method for preventing or reducing ischemia/reperfusion induced myocardial cell death in a human is provided as are methods for identifying pharmaceuticals which interfere with PUMA function. Also herein provided is a method... Agent: Kevin M. Farrell

20080009031 - Mutant cells with altered sialic acid: The invention provides cells useful to propagate influenza virus mutants having reduced sialidase activity.... Agent: Schwegman, Lundberg & Woessner, P.A.

20080009035 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080009037 - Protein glycosylation modification in methylotrophic yeast: The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified glycosylation. Methods of producing glycoproteins with reduced and/or modified glycosylation using such genetically engineered strains of Pichia are also provided. Vectors, which comprise coding sequences for... Agent: Leopold Presser Scully, Scott, Murphy & Presser

20080009034 - Recycling system for manipulation of intracellular nadh availability: The present invention describes a novel recombinant NADH recycling system that is used as a process for producing reduced compounds. In a specific embodiment, the reduced compounds include ethanol, succinate, lactate, a vitamin, a pharmaceutical and a biodegraded organic molecule. The NADH recycling system effects metabolic flux of reductive pathways... Agent: Baker & Mckenzie LLP

20080009033 - Secretion, transcription and sporulation genes in bacillus clausii: The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods for producing proteins in such host cells, such as members of the... Agent: Kamrin T. Macknight Genencor International, Inc.

20080009040 - Animal protein-free media for cultivation of cells: The present invention relates to animal protein-free cell culture media comprising polyamines and a plant- and/or yeast-derived hydrolysate. The invention also relates to animal protein-free culturing processes, wherein cells can be cultivated, propagated and passaged without adding supplementary animal proteins in the culture medium. These processes are useful in cultivating... Agent: Baxter Healthcare Corporation

20080009041 - Industrially useful microorganism: According to the present invention, the E. coli mutant strain having chromosomal DNA that is at least 470 kbp shorter than that of a wild-type E. coli strain exhibits such a property that the number of the cells after a certain period of culture is greater than a wild-type strain.... Agent: Fitzpatrick Cella Harper & Scinto

20080009042 - Process of high purity albumin production: A process is provided for the preparation of albumin which has extremely low levels of or is essentially free of colorants, metal ions, human proteins, host proteins, fragments of albumin, polymers or aggregates of albumin and viruses, and which is essentially non-glycated, relatively high in free thiol and with an... Agent: Synnestvedt & Lechner, LLP

20080009044 - Biocatalytic oxidation process useful in the manufacture of moxidectin: p

20080009045 - Microorganism having an ability of producing docosahexaenoic acid and use thereof: An object of the present invention is to provide a microorganism which has a high ability of producing docosahexaenoic acid. The present invention provides a Thraustochytrium strain which has an ability of producing docosahexaenoic acid, and use thereof.... Agent: Sughrue Mion, PLLC

20080009046 - Method for the production of optically-active alcohols: The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression cassettes, vectors and recombinant hosts containing said nucleic acid sequences.... Agent: Connolly Bove Lodge & Hutz, LLP

20080009048 - Liquefaction of starch containing material: The present invention relates to method of liquefying starch-containing material, wherein starch-containing material is subjected to a bacterial alpha-amylase at (a) a temperature around 50-80° C. for 10-180 minutes, followed by (b) treatment at a higher temperature than used in step (a) for 1-60 minutes.... Agent: Novozymes North America, Inc.

20080009047 - Non-recombinant saccharomyces strains that grow on xylose: The present invention relates to methods for producing Saccharomyces strains that are capable of growth on xylose as a sole carbon source at a desired growth rate, (such as at least one generation per 48 hours), strains made by such methods, and Saccharomyces strains that grow at a growth rate... Agent: Fish & Richardson PC

20080009049 - Process for producing a starch hydrolyzate: The present invention relates to processes for producing a starch hydrolyzate and optionally a fermentation product, such as ethanol,... Agent: Novozymes North America, Inc.

20080009050 - Regulation of acid metabolite production: The present invention provides a method of preparing acid metabolites, such as mycophenolic acid, and a strain of Penicillium sp. with accession number CCM 8364 for use in such method, which method produces mycophenolic acid at increased yields.... Agent: Kenyon & Kenyon LLP

20080009051 - Method and device for isolating cells: A method for selecting specific cells from amongst a group of cells and a device for implementing the method, the method including the use of a radiation sensitive medium having a first state that does not immobilize cells and a second state that immobilizes cells wherein the radiation sensitive medium... Agent: Martin D. Moynihan Prtsi

20080009052 - Recombinant d-amino acid oxidases: The present invention discloses two novel D-amino acid oxidases, whose activities of converting cephalosporin C to glutaryl-7-aminocephalosporanic acid are at least 25% higher than that of wild-type Trigonopsis variabilis D-amino acid oxidase and the encoding DNA sequences thereof.... Agent: Nath & Associates

20080009053 - Modified ethylenediamine-n, n'-disuccinate: ethylnediamine lyase: The present invention provides a modified ethylenediamine-N,N′-disuccinate:ethylenediamine lyase. The present invention also provides a protein that comprises the amino acid sequence represented by SEQ ID NO: 1; or a protein that comprises an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 1 by deletion,... Agent: Darby & Darby P.C.

20080009054 - Bacterial strain for a metal biosorption process: This invention is referred to a new bacterial strain of Bacillus sp., to be applied in a metal biosorption process, which was deposited in the Agricultural Research Culture Collection (NRRL) International Depositary Authority, 1815 N. University Street, Peoria Ill. 61604, USA, having an accession number NRRL-B-30881. It is described, also,... Agent: Banner & Witcoff, Ltd.

20080009055 - Integrated photobioreactor-based pollution mitigation and oil extraction processes and systems: Integrated systems including a photobioreactor system designed to contain a liquid medium comprising at least one species of phototrophic organism therein, and a facility associated with extracting and/or processing oil extracted from mixtures of oil and solid material, such as an oil sands facility, are described. Processes for using a... Agent: Wolf Greenfield & Sacks, P.C.

20080009056 - Polypeptide, cdna encoding the same and use of them: A new polypeptide prepared from human library by the SST method and a process for preparation of it; a cDNA encoding the polypeptide; a fragment selectively hybridizing with the sequence of the cDNA; a replication or expression plasmid containing the cDNA integrated thereinto; a host cell transformed with plasmid; an... Agent: Sughrue, Mion, Zinn, Macpeak & Seas, PLLC

20080009057 - Hepatic stellate cell precursors and methods of isolating same: The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-1+, VCAM-1+, β3-integrin+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin,... Agent: Foley And Lardner LLP Suite 500

20080009058 - Chimeric ige polypeptides and host cells: The invention provides methods and materials related to expressing chimeric IgE proteins. Specifically, the invention provides nucleic acid vectors, host cells, and methods for producing chimeric IgE polypeptides.... Agent: Fish & Richardson P.C.

20080009059 - Method for growing adult cells: A method for growing adult cells includes harvesting a tissue sample from a subject and breaking the tissue sample into fragments. The fragments are placed into a culture vessel, and at least some of the fragments are induced to adhere to the culture vessel. The fragments are supplied with nutrients... Agent: Patrick R. Scanlon Preti Flaherty Beliveau & Pachios LLP

20080009060 - Methods of discovering chemicals capable of functioning as gene expression modulators: The present invention provides a method of transcriptionally modulating the expression of a gene-of-interest. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded... Agent: Osi Pharmaceuticals, Inc.

20080009061 - Method for preserving pancreatic islet, container for preserving pancreatic islet, and kit for transplanting pancreatic islet: An object of the present invention is to provide a method for preserving pancreatic islet, a container for preserving pancreatic islet and a kit for transplanting pancreatic islet in order to effectively preserve the pancreatic islet. The present invention presents; a method for preserving a liquid including pancreatic islet in... Agent: Kilyk & Bowersox, P.l.l.c.

20080009062 - Nanofiber mesh for cell culture: Disclosed is a mesh for cell culture in which linear nanofiber is cross-linked to form a network, wherein the linear nanofiber is composed of polyhydroxyalkanoate; or polyhydroxyalkanoate, and collagen, gelatin or their mixture. The mesh for cell culture of the present invention can culture cell since the cell, more preferably... Agent: Foley & Lardner LLP

20080009063 - Substrate for cell culture: An object of the present invention is to provide a cell culture substrate capable of quickly forming a cell sheet and easily removing the cell sheet after formed. The present invention relates to a cell culture substrate for forming a cell sheet by culturing cells, comprising a plurality of projections... Agent: Sughrue Mion, PLLC

20080009064 - Temperature-responsive microcarrier: The invention relates to compositions and methods useful for cell culture in which cell adherence and release of cultured cells can be performed in a temperature-responsive manner.... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20080009065 - Genes encoding insect odorant receptors and uses thereof: This invention provides an isolated nucleic acid molecule encoding an insect odorant receptor. This invention provides a nucleic acid molecule of at least 12 nucleotides capable of specifically hybridizing with the nucleic acid molecule encoding an insect odorant receptor. This invention also provides a purified, insect odorant receptor. This invention... Agent: John P. White Cooper & Dunham LLP

20080009066 - Plant gene encoding trehalose metabolism enzymes: This invention relates to isolated nucleic acid fragments encoding trehalose metabolism enzymes, more specifically, alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase. The invention also relates to the construction of a recombinant DNA construct encoding all or a portion of the alpha, alpha-trehalase, alpha, alpha-trehalose-phosphate synthase or trehalose-6-phosphate phosphatase, in... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

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