Chemistry: molecular biology and microbiology inventions 12/07

20070298406 - Suspension medium for red blood cells: The present invention relates to a new suspension medium or diluent solution for red blood cells for use in haematological methods. The suspension medium or diluent solution for red blood cells may comprise a combination of two or more amino acids of any group, and preserves the red blood cells... Agent: Darby & Darby P.C.

20070298407 - Diagnostic kits and methods for diagnosis of axial pain with or without radiculopathy: The invention provides kits developed to analyze ex vivo, a sample retrieved from the area of the pathological condition for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively,... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20070298441 - Antibody-based method for isolating th1 and th2 helper lymphocytes from human peripheral blood: A negative isolation method for separately isolating preparations of Th1 and Th2 helper lymphocytes from peripheral blood mononuclear cells involving the use of novel combinations of monoclonal antibodies to separately sequester specific Th1 and Th2 lymphocytes and contaminating leukocytes and erythrocytes, adding a magnetic colloid to the cells, and using... Agent: Dr. Melvin Blecher

20070298408 - Reagent for sample analysis, reagent kit for sample analysis and method for sample analysis: A reagent for measuring a basophil and/or a nucleated red blood cell is described. The reagent comprises (a) an alcohol having 4 to 8 total carbon atoms, and (b) one or more fluorescent dyes selected from the group consisting of a compound of the general formula (I) and a compound... Agent: Sughrue Mion, PLLC

20070298410 - Assay to detect hcv receptor binding: Identification of HCV receptor target cells using HCV receptor-binding ligands and cell separation by flow cytofluorimetry is described. HCV receptor target cells are employed to conduct assays for HCV receptor-binding ligands in order to identify potential HCV vaccine candidates. HCV receptor target cells are used to measure antibody neutralisation to... Agent: Novartis Vaccines And Diagnostics Inc.

20070298409 - Atp-metry for detecting and counting viruses: The invention concerns the use of ATP-metry for detecting and counting viruses, via free adenyl nucleotides of their target host cells or via adenyl nucleotides bound to the viral DNA or RNA The invention also concerns the method for determining viruses by ATP-metry.... Agent: Foley & Lardner LLP

20070298421 - Calpastatin markers for fertility and longevity: Aspects of the present invention provide novel compositions and methods based on novel calpastatin (CAST) genetic markers, such as missense mutations in exon 3 that result in G48D or P52L substitutions (NM_174003.2:c.271G>A and 283C>T), a G/T substitution in intron 3 (AAFC02060381.1:g.2110G>T) and a GAAA repeat in intron 8 (AAFC02060381.1:g.6700[(GAAA)4]+[(GAAA)5]. Particular... Agent: Frommer Lawrence & Haug

20070298411 - Cell culture: A method for determining the effect of a plurality of culture conditions on a cell, comprising the steps of: a) providing a first set of groups of cell units each comprising one or more cells, and exposing said groups to desired culture conditions; (b) pooling two or more of said... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070298420 - Cholesterol transport gene: Methods and compounds are disclosed for lowering serum LDL levels or serum cholesterol levels, or for reducing the transport of cholesterol from the gut to the blood or the lymph, based on the observation that a gene known as ABC1 is necessary in order for cholesterol to be transported from... Agent: Quarles & Brady LLP

20070298417 - Constructs for gene expression analysis: The present invention relates generally to constructs and their use in gene expression or gene regulation assays. More particularly, the present invention provides expression vectors and/or reporter vectors providing kinetics of protein expression with improved temporal correlation to promoter activity. Even more particularly, the invention provides expression vectors comprising a... Agent: Knobbe Martens Olson & Bear LLP

20070298414 - Engineering enzymes through genetic selection: Methods and compositions for selecting transformed cells are provided. An exemplary method combines chemical complementation with genetic selection to identify desirable transformed cells.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070298412 - Fluorescent proteins and chromoproteins from non-aequorea hydrozoa species and methods for using same: The present invention provides nucleic acid molecules encoding a fluorescent and chromo-proteins and mutants, variants and derivatives thereof, as well as proteins and peptides encoded by these nucleic acids. The nucleic acid molecules and proteins of interest are isolated from non-Aequorea Hydrozoa species. The proteins of interest include yellow fluorescent... Agent: Ladas & Parry

20070298416 - Genes associated with canine osteoarthritis and related methods and compositions: Described herein is a combination containing polynucleotide molecules that are differentially expressed in osteoarthritis. Also described are methods that may be used for diagnosis and prognosis of osteoarthritis, as well as methods that may be used to screen test substances for effectiveness in treatment modalities for osteoarthritis. Also described are... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070298423 - Identification of multiple biological (micro) organisms by specific amplification and detection of their nucleotide sequences on arrays: The present invention is related to a method for identifying and/or quantifying an organism or part of an organism in a sample by detecting a nucleotide sequence specific of said organism, among at least 4 other nucleotide sequences from other organisms or from parts of the organism. The method includes... Agent: Knobbe Martens Olson & Bear LLP

20070298419 - K-ras oligonucleotide microarray and method for detecting k-ras mutations employing the same: Since the K-ras oligonucleotide microarray of the present invention can detect K-ras mutations by applying a competitive DNA hybridization method to the oligonucleotides spotted on a solid matrix different from the previously reported method for detecting a mutation, it makes the more precise analysis and can reduce experimental cost and... Agent: Sughrue Mion, PLLC

20070298415 - Method of amplifying nucleic acid: In the case where a template nucleic acid has sequences substantially the same as each other, a primer is designed in a region between these sequences so as to give a product in a ladder structure in which a target region is polymerized in a single sequence via the same... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070298431 - Method of monitoring colorectal cancer: A method and kit is described for individualized stool surveillance for occurrence/recurrence of preneoplastic or neoplastic lesions based on the analysis of genetic mutations and methylation pattern detected in biopsy tissue removed during polypectomie as compared to normal colon mucosa.... Agent: Elizabeth Hart-wells, Ph.d. Room 021

20070298427 - Methods of gene expression analysis: The present invention relates to methods for cost effective, high throughput, multiplexed nucleic acid (gene) expression analysis using photobiotin-labeled anti-sense RNA (aRNA) as hybridization probes in conjunction with a multiplex capable system. The use of the relatively inexpensive photobiotin provides a cost effective alternative to the use of currently available,... Agent: Zymogenetics, Inc. Intellectual Property Department

20070298418 - Molecules involved in protein folding: The present invention provides a method of identifying a molecule which functions as a catalyst of protein folding in a cell, which comprises: (a) transforming a library of cells with a gene encoding a reporter protein; (b) selecting those cells which contain said gene but wherein said reporter protein has... Agent: Michael Best & Friedrich LLP

20070298424 - Nucleic acids and corresponding proteins entitled 273p4b7 useful in treatment and detection of cancer: A novel gene 273P4B7 and its encoded protein, and variants thereof, are described wherein 273P4B7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table 1. Consequently, 273P4B7 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 273P4B7 gene or... Agent: Agensys C/o Morrison & Foerster LLP

20070298425 - Population scale hla-typing and uses thereof: The present invention provides a portable system for real-time population-scale HLA genotyping and/or allelotyping in a field environment and methods of such population-scale HLA genotyping. The individual components of the system are portable to and operable within a field environment thereby providing high throughput with real-time geno- or allelotyping. Also... Agent: Benjamin Aaron Adler Adler & Associates

20070298422 - Procedure for the analysis of a sample: A procedure for the analysis of a sample is disclosed, where the sample includes at least one nucleic acid molecule having at least one nucleic acid sequence. In at least one embodiment, the procedure includes making available a comparison molecule of known concentration having a known comparison sequence, where the... Agent: Harness, Dickey & Pierce, P.L.C

20070298429 - Process for determining the concentration of nucleic acids: A process is disclosed for determining the concentration of nucleic acids in a sample in a microfluidic device. In at least one embodiment, the method includes a) introducing the sample into a first chamber, b) carrying out a number of cycles of an amplification reaction to be carried out in... Agent: Harness, Dickey & Pierce, P.L.C

20070298428 - Pyrophosphorolysis activated polymerization (pap): A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3′-deoxynucleotide at its 3′ terminus. PAP can be applied for exponential amplification or for linear... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070298430 - Ribosome display or mrna display method with selection for increased stability of the protein: A method of providing a subject polypeptide variant with improved stability compared with a parent subject polypeptide, employing translation and selection using an RNA expression system, wherein two or more stability selection pressures are applied simultaneously during translation, two or more stability selection pressures are applied simultaneously during selecting, or... Agent: Klarquist Sparkman, LLP

20070298413 - Topoisomerase modulators assays: The present invention provides methods for screening for compounds that modulate, e.g. inhibit, the activity of topoisomerases such as DNA gyrase, comprising providing cells expressing topoisomerase and containing a promoter sensitive to changes in DNA topology having a reporter gene operatively linked thereto, and measuring the expression of said reporter... Agent: Astrazeneca R&d Boston

20070298426 - Warfarin dosage prediction: This invention relates to predicting a patient's warfarin dose based on the nucleotide at position −1639 of the VKORC1 gene and the genotype of the CYP2C9 gene in that patient. The warfarin dose so predicted can be further adjusted according to the patient's non-genetic factors, e.g., age, body surface area,... Agent: Occhiuti Rohlicek & Tsao, LLP

20070298433 - Assay device and method: An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion (140) of a surface (130) of a microfluidic chamber (120,122,124); passing a fluid sample over the surface... Agent: Wolf Greenfield & Sacks, P.C.

20070298432 - Binding assay components: In one embodiment, the present invention provides a detection complex which is useful for detecting a specific analyte of interest in a sample. The complex comprises a detection marker indirectly connected to an analyte binding partner by a bridging complex. This arrangement serves to preserve or enhance the availability of... Agent: Scully, Scott, Murphy & Presser, P.C.

20070298436 - Changeable machine readable assaying indicia: A machine readable assaying system comprising a test card having machine readable assaying means. A plurality of individual analysis strips, each strip comprising antibodies and/or reagents capable of indicating the positive presence of distinct illicit substances form a pattern of elements including one or more fixed strips and one or... Agent: Hovey Williams LLP

20070298434 - Library of toxin mutants, and methods of using same: This application relates to libraries of toxin mutants, and to methods of using same in the development of targeted against specific cell types.... Agent: Marina Larson & Associates, LLC

20070298435 - Probe complex: [PROBLEMS] To provide a soluble highly sensitive probe complex with high functional capability ensuring usability in immunoassays of high sensitivity. [MEANS FOR SOLVING PROBLEMS] A highly sensitive probe complex can be produced by linking hydrophilic intermediums to a carrier and linking detection markers such as biotin, haptens or low-molecular-weight peptides... Agent: Thompson Coburn, LLP

20070298437 - Methods of identifying compounds that modulate il-4 receptor-mediated ige synthesis utilizing a chloride intracellular channel 1 protein: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a chloride intracellular channel 1 (CLIC1) as a surrogate analyte and methods of using the compounds in a variety of in vitro,... Agent: Bozicevic, Field & Francis LLP

20070298442 - Method for identifying jnk and mlk inhibitors for treatment of neurological conditions: The present invention describes methods for identifying compounds that inhibit JNK and MLK kinase activity as drugs for treating a mammal susceptible to or having a neurological condition. This invention also discloses methods for preventing neuronal cell death and treating neurological conditions that involve neuronal cell death, particularly neurodegenerative diseases... Agent: Cephalon, Inc. C/o Mccarter & English, LLP

20070298445 - Cancer therapeutic: Methods for the delivery of a siNA to a cell via a liposome are provided. In certain embodiments, the siNA may bind to a nucleotide sequence encoding ZNF306 protein. These methods may be used to treat a disease, such as cancer. One example of a composition is a composition comprising... Agent: Baker Botts, LLP

20070298444 - Methods and compositions for use in evaluating and treating neoplastic disease conditions: Methods and compositions for use in a evaluating and treating neoplastic disease conditions are provided. In certain embodiments of the subject invention, the presence of at least one target protein associated with cellular locomotion is determined in a cell to make an evaluation regarding the cell and/or host from which... Agent: Bozicevic, Field & Francis LLP

20070298443 - Screening method using antibody heavy chains: The present invention relates to a method of screening which includes an antibody heavy chain and a reporter gene, such as a camel antibody and beta-lactamase, respectively.... Agent: Elena E. Quertermous Danisco US Inc., Genencor Division

20070298446 - Reducing time to result for blood bank diagnostic testing: Methods for reducing time to result in blood bank diagnostic testing with an agitation device and a low ionic strength solution are disclosed. Specifically provided are methods for reducing incubation time for antigen-antibody reactions in an immunohematologic assay by subjecting the assay reactants to incubation with agitation and optionally additionally... Agent: Philip S. Johnson Johnson & Johnson

20070298438 - Methods and compositions for determining enzymatic activity: The present invention comprises crystalline polyketide synthases, isolated non-native polyketide synthases having the structural coordinates of said crystalline polyketide synthases, and nucleic acids encoding such non-native polyketide synthases. Also disclosed are methods of predicting the activity and/or substrated specificity of putative polyketide synthase, methods of identifying potential polyetide synthase substrates,... Agent: Foley & Lardner LLP

20070298439 - Nmr-solve method for rapid identification of bi-ligand drug candidates: Methods for rapidly identifying drug candidates that can bind to an enzyme at both a common ligand site and a specificity ligand site, resulting in high affinity binding. The bi-ligand drug candidates are screened from a focused combinatorial library where the specific points of variation on a core structure are... Agent: Mcdermott, Will & Emery

20070298440 - Compounds that modulate processes associated with ige production and methods and kits for identifying and using the same: The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a retinoid X receptor as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro... Agent: Bozicevic, Field & Francis LLP

20070298447 - Method for diagnosing immunologic food sensitivity: The invention includes novel methodology for diagnosing immunologic food or drug sensitivities. The method for diagnosing food sensitivities includes using diagnoses of other related disorders, such as microscopic colitis or other chronic immunologic/autoimmune syndromes, chronic diarrhea, irritable bowel syndrome, and hepatitis C and other hepatic diseases, Crohn's disease, alcoholism, and... Agent: Storm LLP

20070298448 - Enrichment of enzymatic cleavage products: The invention relates to a method for the enrichment, isolation and/or identification of cleavage products of at least one enzyme from a sample. According to the invention, an enzymatically inactive mutant of a protease is used as an affinity material, said mutant furthermore maintaining its specific substrate nature. At least... Agent: Seed Intellectual Property Law Group PLLC

20070298450 - Compositions and methods for cell characterization: The present invention relates to compositions and methods for identification, sorting and enrichment of cells. In particular, the present invention provides compositions and methods for quantitation of cell motility by measurement of individual cell motility, and rapid isolation of cell populations, using fluorescent signal within single cells. Such compositions and... Agent: Medlen & Carroll, LLP

20070298449 - Utilization of cell forcibly expressing toll-like receptor: Cells with forced expression of swine Toll-like receptor 9 (TLR9) are prepared by cloning a TLR9 gene from swine intestinal Peyer's patches. Functional analysis on CpG DNAs using the above cells revealed that swine TLR9 shows a higher recognition ability for a human CpG DNA motif (CpG2006) than for a... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070298451 - Method and unit for preparing a sample for the microbiological analysis of a liquid: The method of preparing such a sample comprises the step of procuring such a preparation unit (1), the step of passing a predetermined volume of said liquid through said first membrane and through said second membrane (4) in order to collect a sample on said second membrane (4); and the... Agent: Nields & Lemack

20070298452 - Advanced selective plating media: Selective growth media N4 agars that include a combination of high levels of yeast extract, possibly higher levels of protein, elevated levels of sugar and reduced levels of sodium chloride. The combination of ingredients provides the ability to detect Salmonella spp. and Shigella spp. with almost identical sensitivity while alleviating... Agent: Jacobson Holman PLLC

20070298453 - Stem cells: A novel human embryonic stem cell line (hES-NCL1) is described together with a method for culturing a blastocyst and obtaining an embryonic stem cell line therefrom. Also described is the spontaneous partial differentiation of the embryonic stem cell line so obtained to produce fibroblast-like cells which act as an autogeneic... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070298454 - Analysis of cell morphology and motility: Determination of the morphology and motility of a population of cells in vitro is possible via a series of steps. The cells are imaged using a microscope and camera. A first frame of image data allows identification of parts of the image data corresponding to a cell or cells of... Agent: Nixon & Vanderhye, PC

20070298455 - Method for preparing a modified host cell: The present invention relates to a method for preparation of a modified host cell which comprises the steps of (a) transfecting a host cell with at least one compound of interest to which a label is covalently coupled and (b) isolating the transfected host cell, wherein the label provides to... Agent: Nixon & Vanderhye, PC

20070298456 - Microbiological process for the production of 7-substitued 11-hydroxy steroids, 7,17-substituted 11-halogen steroids, and uses thereof: A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R7, R10, R11, R13, R17 and R17′ as... Agent: Millen, White, Zelano & Branigan, P.C.

20070298457 - Soluble endoproteases for the in vitro processing of recombinant proteins: The present invention relates to the expression and secretion in Saccharomyces cerevisiae of readily purifiable soluble variants of the Kex1 endopeptidase of Kluyveromyces lactis and the purification and use thereof for the in vitro processing of recombinant proteins usable in industrial applications. The soluble Kex1 endoproteases described here are free... Agent: Darby & Darby P.C.

20070298461 - Dna encoding hyaluronan synthase from pasteurella multocida and methods of use: The present invention relates to a nucleic acid segment having a coding region segment encoding enzymatically active Pasteurella multocida hyaluronate synthase (PmHAS), and to the use of this nucleic acid segment in the preparation of recombinant cells which produce hyaluronate synthase and its hyaluronic acid product.... Agent: Dunlap Codding & Rogers, P.C.

20070298459 - Human tumor necrosis factor receptor tr9: The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070298458 - Method and kit for expressing protein under regulation of the expression from repeated sequence formed by gene amplification, and transformant: A method is disclosed for releasing the transcriptional regulation caused by a repeated sequence in a gene, a kit therefor and so on to thereby establish a system capable of producing a protein in a large amount. At least one embodiment of the method can be achieved by any one... Agent: Harness, Dickey & Pierce, P.L.C

20070298460 - Novel receptor that causes cell death: Isolated apoptosis inducing receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.... Agent: Immunex Corporation Law Department

20070298462 - Process for obtaining antibodies: The present invention relates to the manufacture of recombinant antibodies of therapeutic quality. In particular, the invention relates to methods for increasig the yield of cuntional antibody from large scale fermentations whereby a cultured host cell sample is subjected to a freeze-thaw treatment step.... Agent: Sughrue Mion, PLLC

20070298463 - Variants of human glycoprotein hormone alpha chain: compositions and uses thereof: The present invention provides human glycoprotein hormone (hGPH) α-chain splice variants, including isolated nucleic acids encoding these variants and the encoded amino acid sequences, as well as antibodies, antisense oligonucleotides, expression vectors and host cells comprising these sequences. The present invention further discloses the use of these sequences in the... Agent: Winston & Strawn LLP Patent Department

20070298464 - Methods of producing erythropoietin isoforms comprising lewis-x structures and high sialic acid content and compositions of the same: Disclosed are immortalized human embryonic retina cells, having a nucleic acid sequence encoding an adenoviral E1A protein integrated into the genome of the cells, and further comprising a nucleic acid sequence encoding an enzyme involved in post-translational modification of proteins, such as a sialyltransferase, wherein the nucleic acid sequence encoding... Agent: Trask Britt

20070298465 - Compositions and methods of use for variant helicases: Generally speaking, the present invention relates to variant helicases that lack structural autoinhibition of helicase activity. In particular, the invention provides a composition and a kit comprising a helicase that lacks structural autoinhibition, and a method of unwinding a double helix comprising contacting the double helix with a helicase that... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20070298466 - Method for the construction of randomized gene sequence libraries in cells: An in vivo method for the construction of randomized gene libraries and/or domain replacement in gene libraries by homologous recombination using a Kluyveromyces lactis killer toxin, in particular the (γ-subunit of the K. lactis killer toxin, as negative selection marker is described. The use of the (γ-subunit of K. lactis... Agent: Marshall, Gerstein & Borun LLP

20070298467 - Method of preparing 2-deoxyribose 5-phosphate: The present invention discloses a method of preparing 2-deoxyribose 5-phosphate by reacting glyceraldehyde 3-phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase but substantially no phosphatase or the enzyme derived from the microorganism. The present invention also discloses a method of preparing 2-deoxyribose 5-phosphate... Agent: Birch Stewart Kolasch & Birch

20070298468 - Method of preparing 2-deoxyribose 5-phosphate: The present invention discloses a method of preparing 2-deoxyribose 5-phosphate by reacting glyceraldehyde 3-phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase but substantially no phosphatase or the enzyme derived from the microorganism. The present invention also discloses a method of preparing 2-deoxyribose 5-phosphate... Agent: Birch Stewart Kolasch & Birch

20070298469 - N-epsilon-acyl-l-lysine-specific aminoacylase: The present invention provides an aminoacylase having superior abilities in specifically acylating and hydrolyzing e-amino group of Lys, and a method of producing Nε-acyl-L-lysine. The present invention provides Nε-acyl-L-lysine-specific aminoacylase containing the amino acid sequence of SERPXTTLLRNGDVH (X unknown) at the N-terminal, and a method of producing Nε-acyl-L-lysine comprising acting... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070298470 - Isolated dna comprising one or more genes specific for 5s clavam biosynthesis, vectors comprising such dna and streptomyces hosts capable of improved clavulanic acid production: Novel bacterial genes, microorganisms and processes for improving the manufacture of 5R clavams, eg. clavulanic acid.... Agent: Glaxosmithkline Corporate Intellectual Property - Uw2220

20070298472 - Electrode compositions and configurations for electrochemical bioreactor systems: Electrodes and configurations for electrochemical bioreactor systems that can use electrical energy as a source of reducing power in fermentation or enzymatic reactions and that can use electron mediators and a biocatalyst, such as cells or enzymes, to produce electricity are disclosed. Example electrodes in the system may comprise: (1)... Agent: Mcleod & Moyne, P.C.

20070298471 - Process for the preparation of enantiomerically enriched amines and amides by enzymatic resolution: A process for the preparation of an enantiomerically enriched amine, is performed by a) cleaving a racemic mixture of a reaction product of i) a chiral amine and ii) an acyl donor, in the presence of a hydrolase, to obtain a mixture of an enantiomerically enriched amide and an enantiomerically... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070298473 - Pet family of efflux proteins: The invention provides methods of increasing the production of aromatic carboxylic acids from a host cell via manipulation of the yhcRQP operon encoding a family of efflux proteins. Up-regulation of all or a sub-set of the genes in the yhcRQP were additionally found to enhance tolerance to aromatic carboxylic acids... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070298474 - Enhanced 2-keto-l-gulonic acid production: A method for enhancing a host cell's biosynthetic production of 2-KLG is described. Such method comprises selecting a host cell that has an at least partially intracellular synthetic pathway which utilizes 2,5-DKG to produce 2-KLG; increasing the transport of said 2,5-DKG into said host cell while maintaining the integrity of... Agent: Richard T. Ito Genencor International, Inc.

20070298475 - Preparation of vanillin from microbial transformation media by extraction by means supercritical fluids or gases: Crude solid vanillin-containing material is precipitated from a solution obtained by biotransformation, and purified by a process comprising contacting it with a purification fluid selected from (a) a liquefied gas whose pressure exceeds its critical pressure and whose temperature is below its critical temperature; (b) a supercritical fluid; (c) a... Agent: Young & Thompson

20070298476 - Pentose-fermentative transformed zymobacter microorganisms: This invention provides transformed microorganisms which can produce ethanol from pentose, by introducing pentose metabolizing enzymes into microorganisms belonging to genus Zymobacter which cannot utilize pentose.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070298477 - Method and devices for the continuous processing of renewable raw materials: By means of the continuous pressure hydrolysis of lignocellulose material and subsequent enzymatic hydrolysis of solid unhydrolysed residues is obtained glucose, to which starch raw materials are added and all of which undergoes amylolytic cleavage and spirituous fermentation. Ethanol, furfural, acetic and ligin are obtained. The device, which comprises the... Agent: Coats & Bennett, PLLC

20070298478 - Bio-recycling of carbon dioxide emitted from power plants: The invention provides a method to decrease emission of carbon dioxide from combustion of fossil fuels or other hydrocarbons and to enhance the efficiency of methane production from anaerobic biodigesters. The invention involves feeding carbon dioxide from the exhaust gas of hydrocarbon fuel combustion to an anaerobic biodigester where biomass... Agent: Hugh Mctavish Mctavish Patent Firm

20070298479 - Process for stimulating production of hydrogen from petroleum in subterranean formations: A process for stimulating microbial hydrogen production in a petroleum-bearing subterranean formation, comprising: (a) analyzing one or more components of the formation to determine characteristics of the formation environment; (b) detecting the presence of a microbial consortium, comprising at least one fermentative syntrophic microorganism, within the formation; (c) assessing whether... Agent: Michael Best & Friedrich LLP

20070298480 - Process and apparatus for activating biological material: Effective activation of a biological material such as an enzyme has been demanded. The present invention provides a process for activating a biological material which includes providing a porous material having mesopores; immobilizing a biological material on the pore wall which forms the mesopores; and enhancing the relative activity of... Agent: Fitzpatrick Cella Harper & Scinto

20070298481 - Method for producing a useful intermediate in alkaloid biosynthesis by using rnai technology: The present invention provides a method for producing an intermediate in alkaloid biosynthesis, which comprises: inhibiting the expression of an enzyme that uses said intermediate as its substrate in an alkaloid producing plant cell, plant tissue or plant body by using RNAi technology as well as RNAi gene used for... Agent: Birch Stewart Kolasch & Birch

20070298483 - Method to increase carotenoid production in a microbial host cell by down-regulating glycogen synthase: A method to increase carotenoid production in carotenogenic microbial host cells is provided by down-regulating or disrupting glycogen synthesis. Disruption of glycogen synthase activity in a carotenogenic microbial host cell significantly increased carotenoid production. Carotenogenic microorganisms are also provided that have been optimized for the production of carotenoid compounds through... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070298482 - Process for increased patchulol content in essential oil of pogostemon cablin: A process is provided for improving sensory properties of essential oils by treatment and incubation with a microbial culture during the extraction process. A method for increasing the patchulol content in essential oil extracted from leaves of Pogostemon cablin is provided, comprising contacting a dried patchouli biomass with microbial cultures,... Agent: Morrison & Foerster LLP

20070298484 - Method and device for thermal conditioning of a cell: The invention relates to methods and agents for thermal conditioning of a biological cell, methods and uses of said agents for releasing and insulating ingredients outside the biological cell, and for quantitatively and qualitatively detecting the released ingredient and to a method for sampling biological cells which consists in carrying... Agent: Borden Ladner Gervais LLP Gail C. Silver

20070298485 - Method for separation of glycosaminoglycan from core protein of proteoglycan with the use of xylanase: A method for collection of intact glycosaminoglycan from proteoglycan by cleaving a linkage region of core protein... Agent: Flynn, Thiel, Boutell & Tanis, P.C.

20070298486 - Microchannel apparatus and methods of conducting unit operations with disrupted flow: The invention described herein concerns microchannel apparatus that contains, within the same device, at least one manifold and multiple connecting microchannels that connect with the manifold. For superior heat or mass flux in the device, the volume of the connecting microchannels should exceed the volume of manifold or manifolds. Methods... Agent: Frank Rosenberg

20070298487 - Radio frequency transponder assay: An assay transponder is disclosed. The assay transponder has an RF transceiver that allows the assay transponder to communicate wirelessly with another RF device. The transponder also has a sensor that interrogates an assay associated with the transponder. The assay exhibits a response to a sample environment in which the... Agent: David W. Highet, Vp And ChiefIPCounsel Becton, Dickinson And Company

20070298488 - Waste treatment apparatus: A waste treatment apparatus decomposes waste by the microorganisms to perform annihilation treatment. The waste treatment apparatus includes a treatment tank which accommodates the microorganisms together with the waste, and an agitation device arranged to agitate the microorganisms together with the waste. The agitation device includes a plurality of agitating... Agent: Okada C/o Keating & Bennett, LLP

20070298489 - Novel human membrane proteins and polynucleotides encoding the same: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.... Agent: Lexicon Pharmaceuticals, Inc.

20070298490 - Thermophilic hydrophobin proteins and applications for surface modification: The present invention relates to a thermophilic hydrophobin, TT1, or a protein or polypeptide substantially similar thereto, derived from the thermophilic fungus Talaromyces thermophilus. The invention further relates to a polynucleotide encoding such hydrophobin, as well as to materials coated with such hydrophobin.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070298491 - Human secreted proteins: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors,... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070298492 - Novel pth responsive gene: This invention relates to a novel PTH gene. The invention further relates to methods of screening, diagnosis and development of therapies for bone related disorders.... Agent: Potter Anderson & Corroon LLP/wyeth

20070298493 - Vascular endothelial growth factor d(vegf-d) antibodies and vectors, and methods of uses: VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it,... Agent: Marshall, Gerstein & Borun LLP

20070298494 - Channel forming peptides: The present invention provides a family of peptides based upon the M2GlyR sequence. These peptides are derivatives of the M2GlyR sequence and can be modified at their ends to include a plurality of polar amino acid residues to enhance their solubility. Particularly preferred derivatives include portions of the M2GlyR sequence... Agent: Tracey S. Truitt Erickson & Kleypas, L.L.C.

20070298496 - Method of deriving pluripotent stem cells from a single blastomere: The present invention provides a high efficiency method of deriving pluripotent mammalian stem cells from single, dissociated blastomeres harvested from preimplantation embryos.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070298495 - Method for transdifferentiating cells: An object of the present invention is to provide a method for transdifferentiating a mature cell without using a DNA methylating agent or a DNA demethylating agent. The present invention provides a method for transdifferentiating a finally differentiated mature cell having a first differentiation phenotype into a finally differentiated mature... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070298497 - Method of culturing mesenchymal stem cells: This invention is directed toward methods of expanding mesenchymal stem cells ex vivo.... Agent: Gambro, Inc Patent Department

20070298498 - Adenoviral amplicon and producer cells for the production of replication-defective adenoviral vectors, methods of preparation and use thereof: The present invention relates to a plasmid that can be used for the development of efficient producer cell lines for the production of helper independent adenovirus vectors carrying multiple deletions of non-structural as well as structural genes. More specifically, the present invention provides producer cells which comprise a novel adenoviral... Agent: Merck And Co., Inc

20070298499 - Methods and compositions for regulating gene expression in plant cells: Novel chimeric plant promoter sequences are provided, together with plant gene expression cassettes comprising such sequences. In certain preferred embodiments, the chimeric plant promoters comprise the BoxII cis element and/or derivatives thereof. In addition, novel transcription factors are provided, together with nucleic acid sequences encoding such transcription factors and plant... Agent: Bryan Cave LLP

20070298500 - Formaldehyde dehydrogenase genes from methylotrophic yeasts: The present invention provides formaldehyde dehydrogenase genes (FLD) from methylotrophic yeasts. The FLD structural genes confer resistance to formaldehyde and are therefore useful as a selectable marker in methylotrophic yeasts. The FLD promoter sequences are strongly and independently induced by either methanol as sole carbon source (with ammonium sulfate as... Agent: Leopold Presser Scully, Scott, Murphy & Presser

20070292842 - Detection of viral or viral vector integration sites in genomic dna: Methods for detecting the integration of viral nucleic acids into a host cell, and methods for determining the locus of integration using microarrays are described. The methods can also be used in conjunction with viral vectors used in gene therapy.... Agent: Agilent Technologies Inc.

20070292877 - Labels for electronic detection of individual molecules and methods for their detection: The invention provides labels for electronic detection of individual molecules. The labels are comprised of elements with different electrical properties that affect the electric current flowing through a nanoelectrode. The labels are of polymeric or filamentous structure where the elements are arranged linearly along their length. The arrangement of the... Agent: Black Lowe & Graham, PLLC

20070292882 - Method and apparatus for detecting cancer cell: A method for determining a cancer cell which has good precision and high reliability, including a step of quantitating an mRNA transcribed from a tumor marker gene contained in a biological sample, a step of quantitating a polypeptide translated from the tumor marker gene in the biological sample, and a... Agent: Sughrue Mion, PLLC

20070292884 - Methods and compositions for obtaining amplifiable nucleic acids from tissues, cells, or viruses exposed to transport media: An additive that substantially compensates for the adverse affects of transport media on the extraction and amplification of nucleic acids from tissue samples and a method for using the additive. The additive is combined with the transport media, either before, during or after the tissue sample is combined with the... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20070292890 - Chemiluminescence chip and chemiluminescence detecting apparatus using the same: Disclosed herein are a chemiluminescence chip, which is used to detect and quantify various kinds of materials in the case of performing the enzyme labeling of a material to be measured and performing the chemiluminescence measurement of the activity of the labeled enzyme, and a chemiluminescence detecting apparatus using the... Agent: Flynn Thiel Boutell & Tanis, P.C.

20070292891 - Tacrolimus standard and methods of using same: A composition and kit useful as a tacrolimus standard solution for immunoassays, and methods for making and using same. The composition and kits include a known amount of tacrolimus or a derivative thereof, and a non-specific protein capable of forming a complex with the tacrolimus or derivative thereof. The standard... Agent: Dade Behring Inc. Legal Department

20070292897 - Analysis kit for living organism and chemical reaction: There is provided a simple, inexpensive reaction analysis kit and system capable of performing highly sensitive, quantitative measurement. A chemical luminescence reaction is employed and a sensor element is used to detect the reaction in a highly sensitive manner. That is, a reaction detection plate is used to transmit a... Agent: Stanley P. Fisher Reed Smith LLP

20070292919 - Composition and methods for improving the production of fermentation operations: Methods and compositions for improving the production of a non-terpene organic compound by a microorganism in a fermentation medium are provided, where the method comprises adding to the fermentation medium a combination of a terpene and a surfactant in an amount sufficient to improve the production of the non-terpene organic... Agent: Nelson Mullins Riley & Scarborough, LLP

20070292836 - Methods for sorting undifferentiated cells and uses thereof: A method of sorting undifferentiated cells is provided. Subpopulations of cells contained in a single line of ES cells can be sorted using cell-surface markers. The sorted undifferentiated cells have ability to produce chimera with high contribution and germ line transmission efficiently. These undifferentiated cells can be used as a... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070292837 - Multiwell plate: A mulitwell plate having a plurality of picowells on the bottom of the wells of the plate as well as methods of producing the mulitwell plate are provided. Provided is also a method of handling living cells by providing an ordered array of living cells immobilized in a non-fluid matrix,... Agent: Martin D. Moynihan Prtsi, Inc.

20070292838 - System and method for stimulation and optical surveying in a non invasive manner of the electrical activity of at least a cell: This invention relates to an apparatus and a method for optically stimulating and detecting the electrical activity of at least one cell (2A, . . . , 2D) in a cell culture (2) placed on a substrate (3). The apparatus (1) is capable of exciting a bio-activatable molecule (16) positioned... Agent: Nixon & Vanderhye, PC

20070292839 - Assay: The invention relates to a method of determining the amount or presence of antibodies to an immunogen in a blood sample comprising at least the steps of detecting the amount or presence of plasma antibodies or parts thereof and lymphocyte antibodies or parts thereof in said sample, wherein said plasma... Agent: Morgan Lewis & Bockius LLP

20070292841 - Detection of human papillomavirus: The present invention relates to in vitro methods of screening human subjects for the presence of human papillomavirus (HPV) which exhibits loss of regulation of E6/E7 mRNA expression and loss of replication and/or expression of a stabilized pre-mRNA encoding full length E6 protein. In particular, the invention provides in vitro... Agent: Wolf Greenfield & Sacks, P.C.

20070292844 - Enhanced biohazard detection system: An enhanced biohazard detection system and a method for detecting, screening and analyzing biological agents are disclosed. The system incorporates an immunoassay detection device to provide a more robust, less expensive method for detecting biological agents in air samples collected at strategically located monitored sites. The immunodetection based assays may... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070292843 - Method for attachment of silylated molecules to glass surfaces: A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070292840 - Replication competent hepatitis c virus and methods of use: The present invention provides replication competent polynucleotides that include a coding sequence encoding a hepatitis C virus polyprotein having adaptive mutations. The invention also includes methods for malting replication competent polynucleotides, identifying a compound that inhibits replication of a replication competent polynucleotide, selecting a replication competent polynucleotide, and detecting a... Agent: Mueting, Raasch & Gebhardt, P.A.

20070292859 - Association of protein polymorphisms with coronary heart disease: The invention concerns methods of identifying an increase in risk for coronary heart disease in an individual, wherein the presence of another amino acid than Glutaminic Acid at position 23 and/or the presence of another amino acid than Valine at position 337 in the Kir6.2 protein is determined in a... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20070292873 - Bacterial iron acquisition targets: Screening methods for identifying compounds that inhibit the SirABC iron-siderophore transport system.... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070292869 - Compositions and methods for analyzing renal cancer: Compositions, methods and kits useful for the diagnosis, prognosis, and treatment of renal cell cancer are provided.... Agent: Sheridan Ross PC

20070292880 - Compositions and methods for detecting predisposition to a substance use disorder or to a mental illness or syndrome: The present invention provides screening kits, compositions, and diagnostic methods for determining whether a subject has a predisposition to, or likelihood of having, a substance use disorder or mental illness or syndrome by determining a nucleic acid expression profile from a biological sample from the subject, wherein a given profile... Agent: Viksnins Harris & Padys Pllp

20070292864 - Compositions and methods for detection of a target nucleic acid sequence: The present invention is directed compositions having a Fen nuclease consisting of a 5′ to 3′ exonuclease and/or endonuclease activity and one or more dNTPs.... Agent: Agilent Techologies Inc

20070292854 - Corn event pv-zmgt32(nk603) and compositions and methods for detection thereof: The present invention provides a DNA construct that confers tolerance to transgenic corn plant. Also provided are assays for detecting the presence of the PV-ZMGT32(nk603) corn event based on the DNA sequence of the recombinant construct inserted into the corn genome and of genomic sequences flanking the insertion site.... Agent: Monsanto Company

20070292847 - Cyclic nucleotide-specific phosphodiesterases from leishmania and uses thereof: The present invention relates to novel amino acid and nucleic acid sequences of cyclic nucleotide-specific phosphodiesterases from the parasite Leishmania major. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the amino acid and... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070292870 - Cytochrome p450 genetic variations: A primer set used to screen a polynucleotide sample to detect and identify variants in the Cytochrome P450 isoenzyme 2D6 (CYP2D6) gene. A method of screening a polynucleotide sample to detect and identify the presence of one or more than one variant in the CYP2D6 gene in the sample. A... Agent: Sheldon Mak Rose & Anderson PC

20070292866 - Diagnosing human diseases by detecting dna methylation changes: This invention relates to methodologies that detect global changes in the methylation of human genomic DNA as well as changes in methylation in specific regions of the human genome. The methodologies have utility in the diagnosis, prognosis and monitoring of therapeutic treatment for any human disease. Further, the invention relates... Agent: Peter G. Carroll Medlen & Carroll, LLP

20070292853 - Dna array and method for detecting single nucleotide polymorphism: A DNA array for detecting a single nucleotide polymorphism of a gene, which comprises, on a solid support, a first probe spots group consisting of one or more probe spots each containing one or more probes hybridizable with a polynucleotide of the gene, in which the probes are exactly complementary... Agent: Oliff & Berridge, PLC

20070292862 - Enhanced transgene expression by co-expression with a suppressor of post-transcriptional gene silencing (ptgs): Disclosed are a variety of methods for achieving enhanced expression from a target nucleotide sequence in a plant e.g. comprising the step of transiently introducing into a tissue of a plant (e.g. a leaf) a first nucleic acid comprising the target nucleotide sequence and a second nucleic acid encoding a... Agent: Dann, Dorfman, Herrell & Skillman

20070292874 - Genes associated to sucrose content: Modern sugarcane cultivars are complex hybrids resulting from crosses among several species of the Saccharum genus. Traditional breeding methods have been extensively employed in different countries along the past decades to develop varieties with increased sucrose yield, and resistant to plagues and diseases. Conventional varietal improvement is, however, limited by... Agent: Morrison & Foerster LLP

20070292848 - Hormone receptor genes and migraine susceptibility: A method of determining whether an individual has a predisposition to migraine is provided, which method includes the step of isolating a nucleic acid that has a guanine to adenine polymorphism at nucleotide 2014 of a human estrogen receptor and/or a nucleic acid that has a 306 base pair insertion... Agent: Knobbe Martens Olson & Bear LLP

20070292885 - Human cdnas and proteins and uses thereof: The invention provides polynucleotides and polypeptides encoding an isolated amyloid inhibitor protein (APIP) and compositions thereof. The polypeptides of the subject invention can be used to inhibit the catabolism or sequential cleavage of amyloid beta precursor protein (APP) by sequential cleavage of APP by beta secretase and gamma secretase.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070292875 - Human rnase h1 oligonucleotide compositions thereof: The present invention provides oligonucleotides that can serve as substrates for human Type 2 RNase H. The present invention is also directed to methods of using these oligonucleotides in enhancing antisense oligonucleotide therapies.... Agent: Woodcock Washburn LLP

20070292850 - Identification of diagnostic markers for communicable subacute spongiform encephalopathies: The invention relates to biological markers of transmissible subacute spongiform encephalopathies and to uses thereof in diagnostic methods. The invention also relates to tools and/or kits that can be used for carrying out said methods (reagents, probes, primers, antibodies, chips, cells, etc.), to their preparation and to uses thereof. The... Agent: Nixon & Vanderhye, PC

20070292872 - Isolation of mesenchymal stem cells: Methods and compositions are provided for the identification and isolation of mammalian mesenchymal stem cells. The methods of the invention provide a means to obtain substantially homogeneous MSC populations. In some embodiments, the homogeneous MSC composition is stable in non-differentiating culture conditions, where the proportion of cells in the composition... Agent: Bozicevic, Field & Francis LLP

20070292857 - Mapping histone modifications by dna microarray: Many human diseases are now realized to have epigenetic features. Post-translational modification of histones plays a major role in these epigenetic features. Chromatin immunoprecipitation assay (ChIP) is currently the method of choice for localizing histone modifications in a step-wise fashion. This technique utilizes histone modification-specific antibodies to enrich DNA (ChIP... Agent: Perkins Coie LLP

20070292855 - Method and cmos-based device to analyze molecules and nanomaterials based on the electrical readout of specific binding events on functionalized electrodes: A device having a functionalized electrode having a probe molecule, wherein the device has an ability to electrically detect a molecular binding event between the probe molecule and a target molecule by a polarization change of the functionalized electrode is disclosed. The device could also include an unfunctionalized electrode that... Agent: Valery M. Dubin

20070292846 - Method for detecting and/or identifying bacteria of the genus staphylococcus: d

20070292852 - Method of detecting and identifying lactic acid bacterium: There are provided a method of detecting potentially beer-spoiling lactic acid bacteria, and a method of simultaneously detecting and distinguishing different lactic acid bacteria including such bacteria.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070292871 - Method of screening for cytochrome p450s: The present invention relates to p450 enzymes and nucleic acid sequences encoding p450 enzymes in Nicotiana, and methods of using those enzymes and nucleic acid sequences to alter plant phenotypes.... Agent: Fish & Richardson P.C.

20070292883 - Method of treating diseases with parp inhibitors: The present invention relates to methods of identifying a disease treatable with PARP modulators by identifying a level of PARP in a sample of a subject, making a decision regarding identifying the disease treatable by the PARP modulators wherein the decision is made based on the level of PARP. The... Agent: Wilson Sonsini Goodrich & Rosati

20070292865 - Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe: The invention relates to compositions and methods for generating a signal indicative of the presence of a target nucleic acid in a sample utilizing a cleavage resistant probe.... Agent: Agilent Techologies Inc

20070292876 - Methods for identification of compounds that mimic the senescence-inducing activity of retinoic acid receptor ligands: The invention relates to the induction of senescence in neoplastic cells. More particularly, the invention relates to the use of small molecule compounds to mediate such induction of senescence. The invention provides methods for identifying such compounds, and methods for using the compounds.... Agent: Keown & Zucchero, LLP

20070292851 - Methods for identifying candidate compounds for treating, reducing, or preventing pathogenic infections: Disclosed are methods for identifying candidate compounds for treating, reducing, or preventing a pathogenic infection, the methods including: (a) contacting a pathogenic cell with a candidate compound; and (b) measuring the production of a molecule selected from the group consisting of an 4-hydroxy-2-alkylquinoline (HAQ) molecule, 4-hydroxy-2-heptylquinoline (HHQ) molecule, or a... Agent: Clark & Elbing LLP

20070292849 - Methods for identifying risk of low bmd and treatments thereof: Provided herein are methods for identifying a risk of low BMD in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating low BMD-related disorders, such as osteoporosis, and therapeutic and preventative methods applicable to osteoporosis. These embodiments are based upon an analysis... Agent: Grant Anderson LLP C/o Portfolioip

20070292878 - Methods for quantitating small rna molecules: In one aspect, the present invention provides methods for amplifying a microRNA molecule to produce DNA molecules. The methods each include the steps of: (a) using primer extension to make a DNA molecule that is complementary to a target microRNA molecule; and (b) using a universal forward primer and a... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20070292863 - Methods of detection of a target nucleic acid sequence: The present invention is directed to methods of generating a signal indicative of the presence of a target nucleic acid in a sample by forming a cleavage structure comprising duplex and single-stranded nucleic acid by incubating a sample comprising a target nucleic acid with a thermostable nucleic acid polymerase substantially... Agent: Agilent Techologies Inc

20070292881 - Methods of diagnosing and treating rheumatoid arthritis and osteoarthritis: The invention provides a novel cell that is a precursor of a fibroblast-like synovial cell. The novel cell is a circulating synovial tissue cell that stains positive for collagen, CD34, CD45, prolyl 4-hydroxylase and CD14. The invention also relates to methods of diagnosing or monitoring rheumatoid arthritis and/or osteoarthritis using... Agent: Fulbright & Jaworski L.L.P.

20070292845 - Novel ubiqutin proteases: The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the... Agent: Millennium Pharmaceuticals, Inc.

20070292856 - Nucleic acid cleavage assays: The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5′ nuclease activity of a... Agent: Casimir Jones, S.c.

20070292868 - Nucleic acid detection method involving the direct generation of a measurable signal: A nucleic acid detection method involving the direct generation of a measurable signal, by the action of an enzyme with 3′-5′ nuclease activity, and the applications for it, the signal generated can be detectable and quantifiable and can be carried out in real-time, in this method, the nucleic acid is... Agent: Banner & Witcoff, Ltd.

20070292886 - Reagents and methods for detecting neisseria gonorrhoeae: This invention provides compositions and methods for detecting Neisseria gonorrhoeae in a sample. This invention also provides related reaction mixtures, kits, systems, and computers.... Agent: Roche Molecular Systems Inc Patent Law Department

20070292858 - Sample multiprocessing: A sample processing cartridge may include a plurality of segments arranged in an array at least two rows long and two columns wide. Each segment may be defined by at least one wall of the sample cartridge, fluidly isolated from adjacent segments at least in part by at least one... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070292867 - Sequence determination using multiply tagged polymerizing agents: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070292860 - Staphylococcus aureus specific diagnostics: A method for typing sample nucleic acid derived or obtained from a Staphylococcus aureus strain, comprising providing an array comprising a plurality of nucleic acid molecules, wherein said plurality of nucleic acid molecules is derived from a first set of at least two different strains of Staphylococcus aureus, providing at... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20070292879 - Terminal phosphate blocked nucleoside polyphosphates: The present invention describes terminal phosphate blocked nucleoside polyphosphates that are stable at high temperature and their use in nucleic acid amplification and analysis. Current invention further describes charge modified terminal phosphate blocked nucleoside polyphosphates for improved incorporation and direct loading of nucleic acid sequencing reactions onto separating media.... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070292861 - Use of mass labelled probes to detect target nucleic acids using mass spectrometry: The invention relates to the use of mass labelled probes to characterise nucleic acids by mass spectrometry. Thus the invention provides methods of detecting the presence of a target nucleic acid in a sample, using a circularising probe in which a mass tag is present in the probe. Further methods... Agent: Oppenheimer Wolff & Donnelly LLP

20070292889 - Immunoassay magnetic trapping device: A system for immunoassaying a sample comprising providing magnetic beads, connecting signal molecules to the beads, connecting the sample to the magnetic beads with the connected signal molecules, magnetically trapping the magnetic beads with the connected signal molecules and the sample, lysising the sample, and analyzing the sample.... Agent: Eddie E. Scott Assistant Laboratory Counsel

20070292887 - Immunohistochemical methods: The present invention relates to immunohistochemical methods to identify biomarkers. This invention relates to the use of phospho-ERK (pERK) levels in tumor cells as a biomarker for a Raf kinase inhibitor. The invention also provides methods and compositions for diagnostic assays for detecting cancer.... Agent: Jeffrey M. Greenman

20070292888 - Methods for measuring enzyme activities in cells, blood, tumors and tissues: The invention provides improved methods for measuring enzymatic activities involved in the oxidative and non-oxidative pentose phosphate pathways, and other thiamine pyrophosphate containing enzymes, which are commonly elevated in tumor cells. The assays of the invention are useful for optimizing therapeutic dosing and scheduling of drugs acting on the pentose... Agent: Ropes & Gray LLP Patent Docketing 39/361

20070292892 - Uncoupled collagen synthesis and degradation assays: The invention relates to methods for determining the progression of cartilage degeneration diseases, such as osteoarthritis and rheumatoid arthritis, by quantitating collagen synthesis and degradation markers in patient samples. One can determine whether a cartilage degeneration condition is progressing, regressing, or remaining stable by quantitating collagen synthesis and degradation markers... Agent: Sonnenschein Nath & Rosenthal LLP

20070292893 - Screening for neurotoxic amino acid associated with neurological disorders: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods... Agent: Pillsbury Winthrop Shaw Pittman LLP

20070292898 - Functional screening assay: In a second aspect, the present invention provides a cell line comprising any of the aforementioned inducible expression vectors. In particular the T-Rex-293 cells stably transfected with the tetracycline inducible expression plasmids hmGlu1a-pcDNA4/TO (FIG. 4) and hmGlu5a-pcDNA4/TO (FIG. 5) which where deposited at the Belgian Coordinated Collections of Microorganisms (BCCM)... Agent: Philip S. Johnson Johnson & Johnson

20070292899 - Method of protein extraction from cells: Methods for producing a protein extract from cells, such as cells containing viral proteins, are provided. In general terms, the methods involve: increasing the pH of the cells to a pH of at least about pH 10.0 to produce an intermediate composition, and then, in the presence of a non-ionic... Agent: Wilson Sonsini Goodrich & Rosati

20070292901 - Methods and kits for evaluating and measuring the oncological status of tissue samples in three-dimensional physiological matrices: Three-dimensional physiological matrices, methods, apparatus and kits for the expedited design, testing and evaluation of oncological remedies are provided. Key aspects of the inventions include matrices, and especially gel matrices, comprising one or more physiological fibers, which are adapted and arranged to provide conditions which permit behaviors, such as the... Agent: Gary L. Shaffer

20070292900 - Zinc-based screening test and kit for early diagnosis of prostate cancer: The present invention provides methods of determining if an individual is at risk for prostate cancer. The methods measures and compares free and/or bound zinc levels in a semen sample or prostatic fluid, including post massage expressed prostatic fluid, in the potential at risk individual with normal levels. A decrease... Agent: Benjamin Aaron Adler Adler & Associates

20070292902 - Methods of use of one step immunochromatographic device for streptococcus a antigen: A method to determine the presence or absence of Streptococcus Group A antigen in a sample, comprising the following steps: extracting the antigen from the sample in an assay chamber with two or less extraction reagents, wherein the two reagents may be added to the assay chamber in no particular... Agent: Genzyme Corporation Legal Department

20070292894 - Assay method: Detectable levels of fucosylation change in Prostate Specific Antigen when the prostate is cancerous, thereby allowing the reliable early detection of cancer of the prostate.... Agent: Greenlee Winner And Sullivan P C

20070292895 - Assays and methods to detect beta-secretase and its activity in body fluids and tissue extracts: Methods and assays for detecting β-secretase (BACE-1) activity in body fluids or tissue extracts from individuals, particularly individuals who have Alzheimer's disease, are disclosed. A truncated form of BACE-1 was isolated that can be used as a biomarker for Alzheimer's disease.... Agent: Merck And Co., Inc

20070292896 - Sensors employing single-walled carbon nanotubes: Sensing compositions, sensing element, sensing systems and sensing devices for the detection and/or quantitation of one or more analytes, Compositions comprising carbon nanotubes in which the carbon nanotubes retain their ability to luminesce and in which that luminescence is rendered selectively sensitive to the presence of an analyte. Compositions comprising... Agent: Greenlee Winner And Sullivan P C

20070292904 - Ephrin and eph receptor mediated immune modulation: Methods and compositions for immune modulation are described. The methods involve modulating an ephrin or Eph receptor which consequently modulates an immune response, in particular a T cell response, modulates immune adhesion cell, modulates chemotaxis and/or migration or modulates apoptosis. The method is useful in treating a variety of conditions,... Agent: Jagtiani + Guttag

20070292905 - Inhibition of peroxidase enzymatic activity: The present invention deals with reagents and compositions capable of effectively inhibiting peroxidase activity. According to the invention, peroxidase enzymatic activity is blocked with an acidic aqueous solution of a protein denaturing agent. preferred protein denaturing agents are detergents and chaotropic substances.... Agent: Roche Diagnostics Operations Inc.

20070292903 - Method of detemining tropomyosin in chitosan: This invention provides a method capable of easily determining with high accuracy a protein in chitosan, said protein having a potential relevance to the development of an allergy, specifically tropomyosin and the content of the peptide. According to the method, tropomyosin is determined by immunoassay with the chitosan being in... Agent: Kubovcik & Kubovcik The Farragut Building

20070292906 - Assay for measuring acyltransferase activity: The subject matter disclosed and claimed herein relates to a high-throughput assay, and components thereof, for measuring the activity of acyltransferases. The high-throughput assay allows for rapid and accurate screening and identification of compounds that are modulators (e.g., inhibitors or activators) of acyltransferases, that may be used, for example, for... Agent: Louis J. Wille Bristol-myers Squibb Company

20070292907 - Compositions and method for regulating ubiquitin-specific processing proteases: The disclosure contained herein provides compounds and methods for identification of compounds that agonize or antagonize the function of USP14, a member of the ubiquitin-specific processing protease (UBP) family. Over-expression or gain-of-function of UBP's contributes to a range of diseases such as cancer, thus inhibition of USP14 by antagonists may... Agent: Pepper Hamilton LLP Firm 21269 50th Floor

20070292908 - Method for detecting streptococcus agalactiae using alpha-glucosidase activity: The present invention concerns a method for specifically detecting and identifying Streptococcus agalactiae, using a reaction medium comprising at least one α-glucosidase enzymatic substrate.... Agent: Oliff & Berridge, PLC

20070292910 - Co-culture of placental stem cells and stem cells from a second source: The present invention relates to a combination of placental stem cells and stem or progenitor cells derived from a second source, wherein the combination shows improved engraftment as compared to placental stem cells or stem cells from a second source, alone. The combination is referred to as a combined stem... Agent: Jones Day

20070292912 - Diffusion-controlling sensor layer: The invention relates to a diffusion-controlling sensor layer for detecting the biological effect of substances consisting of a diffusion-controlling matrix and sensors suspended therein. The invention further comprises a method and an apparatus for the location-dependent detection of the biological effect of substances using the sensor layer according to the... Agent: Edwards Angell Palmer & Dodge LLP

20070292909 - Fluorescent protein: An object of the present invention is to provide a red or orange fluorescent protein, which is characterized in that the difference (stokes shift) between an excitation peak value (wavelength of maximum absorption) and a fluorescence peak value (wavelength of maximum fluorescence) is greatened, so that the maximum fluorescence can... Agent: Greenblum & Bernstein, P.L.C

20070292918 - Codon optimization method: A heterologous expression in a host Pseudomonas bacteria of an optimized polynucleotide sequence encoding a protein.... Agent: Trask Britt

20070292917 - Composition and methods for expressing reporter molecules in mammalian cells: Disclosed herein is a novel system and methods for expressing exogenous genes, such as genes encoding fluorescent proteins, in mammalian cells. In one embodiment of this system and methods, a gene essential for viral infectivity or replication in cell culture is deleted or inactivated in the genome of a non-mammalian... Agent: Invitrogen Corporation C/o Intellevate

20070292914 - Feedback resistant acetohydroxy acid synthethase mutants: The present invention provides nucleotide sequences coding for acetohydroxy acid synthetase (AHAS) mutants, the mutated enzymes themselves and a process for the fermentative production of branched-chain amino acids using these enzymes in specific hosts in which genes which code for the modified acetohydroxy acid synthetase (AHAS) are expressed.... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070292915 - Human oct-2 variant peptide chains, nucleic acids, and methods: Homo sapiens OCT-2 variant peptide chains are disclosed. Polynucleotides encoding these peptide chains, cells comprising these polynucleotides, and methods of using the forgoing are also disclosed.... Agent: Philip S. Johnson Johnson & Johnson

20070292916 - Mutant protein having the peptide-synthesizing activity: The present invention aims at providing an excellent peptide-synthesizing protein and a method for efficiently producing a peptide. The peptide is synthesized by reacting an amine component and a carboxy component in the presence of at least one of proteins shown in the following (I) and (II). (I) The mutant... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070292920 - Neurotoxins with enhanced target specificity: Modified neurotoxins that contain protease cleavage sites susceptible uniquely to proteases present in certain tissues are described. The toxins can be selectively activated by proteases in muscle or selectively inactivated by proteases in blood.... Agent: Dean G. Stathakis Allergan, Inc. -t2-7h

20070292913 - Novel bacterial expression system: The present invention relates to expression cassettes suitable for the expression of a heterologous gene. Furthermore, the invention relates to recombinant plasmids comprising such expression cassettes. Also, the invention relates to host cells comprising such cassettes or plasmids. Another embodiment relates to promoters for use in an expression cassette and... Agent: Intervet Inc. Patent Department

20070292922 - Regulated expression of recombinant proteins from adeno-associated viral vectors: Single AAV vector constructs for regulated expression of an immunoglobulin molecule or fragment thereof and methods of making and using the same are described. The AAV vectors comprise a regulated promoter operably linked to the coding sequence for a first and second immunoglobulin coding sequence, a sequence encoding a self-processing... Agent: Dla Piper US LLP

20070292921 - Trna synthetases, metrs: The invention relates to metRS polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques. Also disclosed are methods for utilizing metRS polypeptides and polynucleotides in diagnostic assays.... Agent: Swanson & Bratschun, L.L.C.

20070292923 - Process for production of enantiomer-enriched compounds: The present invention relates to a production method of an enantiomer-enriched compound, which includes the following (1) and (2): (1) contacting an enantiomer mixture with a stereoselective dehydrogenase, for which NAD+ (nicotinamide adenine dinucleotide) is a coenzyme, thereby preferentially oxidizing one enantiomer and leaving the other enantiomer to form NADH,... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070292924 - Delta 5 desaturase and its use in making polyunsaturated fatty acids: The present invention relates to a Δ5 desaturase, which has the ability to convert dihomo-γ-linolenic acid (DGLA; 20:3 ω-6) to arachidonic acid (ARA; 20:4 ω-6) and/or eicosatetraenoic acid (ETA; 20:4 ω-3) to eicosapentaenoic acid (EPA; 20:5 ω-3). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturase...