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Chemistry: molecular biology and microbiology November USPTO class patent listing 11/07

20070275389 - Array design facilitated by consideration of hybridization kinetics: Methods, systems and computer readable media for selecting probes for design of a chemical array. A first set of candidate probes is provided for hybridization with a sample at a first hybridization stringency and a second set of candidate probes identical to the first set is provided for hybridization with... Agent: Agilent Technologies Inc.

20070275388 - Dendrimers that possess a single target annealing site and uses thereof: Provided is a polynucleotide dendrimer having a single unique binding site for binding a target molecule, thereby permitting stoichiometric quantification of the dendrimer-bound target molecule. The dendrimer of the invention is useful in conjunction with various methods for detecting, and optionally quantifying, nucleic acids, proteins, polysaccharides, organic compounds, or antigens,... Agent: Agilent Technologies Inc.

20070275411 - Silane mixtures: Silanation compositions containing a mixture of two or more silanation reagents, where at least one silanation reagent includes a functional group capable of supporting polymer synthesis and at least one silanation reagent includes no functional group capable of supporting polymer synthesis are useful in modulating the active site density and... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070275428 - Protein phosphorylation imaging systems, methods of making phosphorylation imaging systems, and methods of use thereof: Briefly described, embodiments of this disclosure include phosphorylation sensing systems, methods of detecting phosphorylation, noninvasive methods for detecting the interaction of a first protein with a second protein within a living animal, fusion proteins including the phosphorylation sensing system, vectors including the phosphorylation sensing system, kits including the phosphorylation sensing... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070275363 - Bioreactor for organ reconstruction and augmentation: Bioreactors are used in neo-organ production to allow for an appropriate environment for the maintenance of healthy culturing conditions from pre-wetting to shipment of the neo-organ. The closed system “all-in-one bioreactor” is designed to allow for minimal exposure of the scaffold to the open air in order to maintain sterility.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070275362 - Placental stem cell populations: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.... Agent: Jones Day

20070275364 - Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070275365 - Human corneal endothelial cells and methods of obtaining and culturing cells for corneal cell transplantation: A method for isolation of human corneal endothelial cells by non-enzymatic harvesting and culturing of endothelial cells in vitro from critical density in a system consisting of extracellular matrix protein coated plastic dishes and growth factor enriched culture medium are used to generate expanded sub-populations of endothelial cells for cell... Agent: Jacobson Holman PLLC

20070275366 - Regulation of sperm function: An extracellular matrix protein, such as fibronectin, vitronectin or laminin, is added to a sperm sample to bring the sperm into a low motility, non-capacitated state or maintain a pre-existing non-capacitated state. Subsequently, at an appropriate time in an in vitro fertilization study or in vivo fertilization procedure, angiotensin II... Agent: Fish & Richardson PC

20070275367 - Type lectin fold as a scaffold for massive sequence variation: This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may... Agent: Townsend And Townsend And Crew, LLP

20070275371 - Colorimetric sensor using polydiacetylene supramolecule: There is provided a polydiacetylene supramolecule comprising diacetylene molecules, capable of immobilizing a receptor molecule having a thiol group. Since the polydiacetylene supramolecule has a receptor immobilized thereon having a thiol group, for example, an antibody, and thus shows color transition when reacting with a sample, an antigen can be... Agent: Kenyon & Kenyon LLP

20070275369 - Detection of molecular interactions: A method and assay are described for measuring the interaction between a ligand and an analyte. The assay can include a suspension of colloidal particles that are associated with a ligand of interest. The colloidal particles are maintained in the suspension at or near a phase transition state from a... Agent: Knobbe Martens Olson & Bear LLP

20070275370 - Method for detecting concentrations of a target bacterium that uses phages to infect target bacterial cells: The invention is directed to a method for detecting low concentrations of bacteria in liquid solution that may or may not be complex liquid solutions. In one embodiment, immunomagnetic separation (IMS) is used to separate target bacterium that may be in a liquid mixture from other constituents in the mixture.... Agent: Dorsey & Whitney, LLP Intellectual Property Department

20070275372 - Methods and reagents for molecular detection of hiv-1 groups m, n and o: Reagents and assays for detecting HIV-1 groups M and O and optionally HIV-1 group N and SIVcpz are provided. The reagents are nucleic acid primers for the hybridization to, amplification and subsequent detection of HIV-1 groups M, N and O and SIVcpz in a biological sample. The primers are oligonucleotides... Agent: Klarquist Sparkman, LLP

20070275368 - Posh associated kinases and related methods: The application provides novel complexes of POSH polypeptides and POSH asoociated kinases. The application also provides methods and compositions for treating a POSH-associated diseases such as viral disorders and cancer.... Agent: Ropes & Gray LLP Patent Docketing 39/41

20070275382 - Biomarkers for the efficacy of somatostatin analogue treatment: Gene expression assays were performed using tissues of monkeys treated with the somatostatin analogue pasireotide at sub-therapeutic dose for 14 days. The assays were analyzed to identify the modes of actions of pasireotide with relationships to therapeutic applications. The effects on the growth hormone/IGF-1 and glucagon/insulin axes were reflected in... Agent: Novartis Corporate Intellectual Property

20070275381 - Chromosome 5 genetic variants related to dyslexia: An isolated polynucleotide or genetic material from human Chromosome 5 that indicates the presence of dyslexia or a predisposition to develop dyslexia in the individual from whom the sample was obtained. A method of diagnosing dyslexia or a predisposition to develop dyslexia.... Agent: Sheldon Mak Rose & Anderson PC

20070275393 - Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains: A novel family of protein libraries comprising CTLDs (C-type Lectin-Like Domains) in which internal polypeptide loop-regions lining the ligand binding sites in CTLDs have been replaced with ensembles of completely or partially randomised polypeptide segments. Tetranectin CTLDs were chosen as framework for the preferred embodiment of the invention; and versatile... Agent: Roberts, Mlotkowski & Hobbes

20070275396 - Detection of dna hybridization with a carbon nanotube label: Methods are provided for the detection and identification of target nucleic acids using a system comprising a nanotube—nucleic acid complex. The complex is comprised of a singly dispersed carbon nanotube and a dispersant nucleic acid molecules that is associated with the carbon nanotube in a non-covalent fashion. Portions of the... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070275397 - Detection of molecular interactions using a reduced affinity enzyme complementation reporter system: Methods and compositions for detecting molecular interactions are provided. Aspects of the invention include the use of a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments of the methods.... Agent: Bozicevic, Field & Francis LLP

20070275403 - Diagnostic methods for determining treatment: The present invention provides methods for identifying cancer patients susceptible to effective treatment with inhibitors of the tyrosine kinase activity of EGFR. The invention is based on the discovery that polysomy of chromosome 7 can be used to selectively identify cancer patients that are likely to be successfully treated with... Agent: Kevin M. Farrell Pierce Atwood

20070275404 - Gene expression signatures associated with tumor stromal cells: Methods are provided for classification of solid tumors other than soft tissue tumors; e.g. carcinomas. The tumor mass of such cancers comprises neoplastic cells of epithelial origin, and surrounding stroma. Methods are provided for classification and analysis of such tumors based on the gene expression signature of the tumor stromal... Agent: Bozicevic, Field & Francis LLP

20070275398 - Genes involved estrogen metabolism: The invention concerns genes that have been identified as being involved in estrogen metabolism, and are useful as diagnostic, prognostic and/or predictive markers in cancer. In particular, the invention concerns genes the tumor expression levels of which are useful in the diagnosis of cancers associated with estrogen metabolism, and/or in... Agent: Heller Ehrman LLP

20070275377 - Isolated photoprotein mtclytin, and use thereof: The invention relates to the photoprotein mtClytin, to its nucleotide and amino acid sequences and to the activity and use of the photoprotein mtClytin.... Agent: Jeffrey M. Greenman

20070275375 - Means and method for the detection of target nucleotide sequences using ligation assays with improved oligonucleotide probe pairs: A pair of oligonucleotide probes comprising a first oligonucleotide probe that comprises a first clamp section that is capable of hybridising to a second clamp section of a second oligonucleotide probe and a first target section that is capable of hybridising to a first section of a target DNA sequence... Agent: Mckenna Long & Aldridge

20070275405 - Member for producing a probe array and probe array producing method: In order to provide a member for producing a probe array that allows producing desired probe arrays immediately once the probe arrangement is established, and to provide a probe array producing method that uses this member for producing a probe array, the pieces F1, F2 . . . Fn are... Agent: Posz Law Group, PLC

20070275380 - Method for distinguishing aml subtypes with aberrant and prognostically intermediate karyotypes: Disclosed is a method for distinguishing AML subtypes with aberrant and prognostically intermediate karyotypes selected from trisomy 8, inv(3), t(3;3), trisomy 11, trisomy 13, trisomy 4, t(1;3), t(6;9), der(5)t(5;11), i(17), del(9q), del(12p), and/or del(20q) in a sample by determining the expression level of markers, as well as a diagnostic kit... Agent: Clark & Elbing LLP

20070275373 - Method of fingerprinting tissue samples: The present invention is directed to methods of determining a copy number of nucleic acids in a biological specimen. More specifically, the invention provides a method for determining an absolute copy number of a transcript or a plurality of transcripts of interest in a biological specimen the size of which... Agent: David S Resnick Nixon Peabody

20070275399 - Methods for calculating codon pair-based translational kinetics values, and methods for generating polypeptide-encoding nucleotide sequences from such values: Provided are methods for calculating codon pair translational kinetics values, creating a synthetic gene for expression in a host organism, and providing codon pair translational kinetic values. The methods typically are directed to refinement of statistical observed versus expected codon pair frequencies using one of several factors such as amino... Agent: Knobbe Martens Olson & Bear LLP

20070275407 - Methods for determining therapeutic index from gene expression profiles: This invention provides methods for determining drug specificity, therapeutic index and effective doses for individual patients. According to the methods of the invention, graded levels of drug are applied to a biological sample or a patient. A plurality of cellular constituents are measured to determine the activity of the drug... Agent: Jones Day

20070275374 - Methods for idendifying drug targets and modulators of neurons and compositions comprising the same: The invention provides methods of identifying drug targets in dopaminergic and/or noradrenergic neurons and to the drug targets identified by such methods. This invention also provides a method of screening for agents that modulate dopaminergic neurons and/or noradrenergic neuron activity, function and/or drug target expression, and agents that bind drug... Agent: Morrison & Foerster LLP

20070275406 - Methods for producing ex vivo models for inflammatory disease and uses thereof: The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-β, TNFα or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070275392 - Microrna motifs: Disclosed are methods of identifying microRNA motifs or microRNA precursors for a target gene or a set of target genes. Also disclosed are related computer-readable media.... Agent: Fish & Richardson PC

20070275400 - Multivariate random search method with multiple starts and early stop for identification of differentially expressed genes based on microarray data: The present invention provides multivariate methods for analyzing microarray gene expression data of high dimensional space and thereby identifying differentially expressed genes. The methods of this invention provide a random search procedure with multiple starts and early stop. Larger sets of differentially expressed genes may be identified using the methods... Agent: Needle & Rosenberg, P.C.

20070275384 - Mutant sodium channel nav1.7 and methods related thereto: Described are mutant Nav1.7 sodium channel alpha-subunits and nucleic acid sequences encoding such mutants. Further described are methods for characterizing a nucleic acid sequence that encodes a Nav1 sodium channel alpha-subunit, methods for determining a Nav 1.7 haplotype, methods for determining a subject's predisposition to a neurologic disorder associated with... Agent: Needle & Rosenberg, P.C.

20070275391 - Novel g-protein coupled receptors and dna sequences thereof: The present invention relates to in particular immune modulatory polypeptides and polynucleotides, recombinant materials and methods for their production. Such polypeptides and polynucleotides are of interest in relation to methods of treatment of diseases whereby immune responses initiated by dendritic cells (DC), monocytes or lymphocytes, play a causal or contributory... Agent: Novartis Corporate Intellectual Property

20070275383 - Novel hybrid probes with heightened luminescence: Hybrid probe particles comprising a nanoparticle of gold of diameter in the range extending from 2 to 30 nm on the surface of which, on the one hand, at least one, and preferably from one to 100, organic probe molecules are grafted by gold-sulphur bonds and on the other hand,... Agent: Clark & Brody

20070275402 - Novel markers for prenatal diagnosis and monitoring: This application provides the use of novel fetal markers for prenatal diagnosis and monitoring of certain pregnancy-related conditions. More specifically, the invention resides in the discovery that certain CpG islands located on fetal chromosome 21 demonstrate a methylation profile that is distinct from that of the corresponding CpG islands located... Agent: Townsend And Townsend And Crew, LLP

20070275394 - Nucleic acid nanostructure and method of manufacturing the same: Provided are a nucleic acid nanostructure including: a substrate; a nucleic acid quadruplex immobilized on the substrate to be vertical with respect to the substrate; a metal ion present in a unit lattice of the nucleic acid quadruplex, the unit lattice being made up of eight nucleobases; and a nanoparticle... Agent: Ladas & Parry LLP

20070275387 - Photocleavable fluorescent nucleotides for dna sequencing on chip constructed by site-specific coupling chemistry: This invention provides a method for determining the sequence of a DNA or an RNA, wherein (i) about 1000 or fewer copies of the DNA or RNA are bound to a solid substrate via 1,3-dipolar azide-alkyne cycloaddition chemistry and (ii) each copy of the DNA or RNA comprises a self-priming... Agent: Cooper & Dunham, LLP

20070275390 - Polymorphisms in fatty acid binding protein 4 (''fabp4'') gene and their associations with carcass traits: The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention relates to the identification of single nucleotide polymorphisms (SNPs) within the bovine... Agent: Frommer Lawrence & Haug

20070275386 - Polymorphisms in the epidermal growth factor receptor gene promoter: The present invention concerns polymorphisms in the epidermal growth factor receptor (EGFR), gene. In some embodiments, the present invention is directed at compositions and methods involving single nucleotide polymorphisms (SNPs) in the promoter of the EGFR gene that affect EGFR expression. The identification of polymorphisms associated with EGFR expression or... Agent: Fulbright & Jaworski L.L.P.

20070275378 - Rapid determination and quantification of mycoplasma contamination using dna chip technology: Disclosed is a method for detecting a microorganism contamination in a culture of eukaryotic cells to be used for gene expression profiling, by using a microarray which has attached on its surface at least one nucleic acid probe representing a gene of a eukaryotic cell and at least one nucleic... Agent: Foley And Lardner LLP Suite 500

20070275385 - Rapid screening method of translational fusion partners for producing recombinant proteins and translational fusion partners screened therefrom: Disclosed are a method for rapid screening suitable translational fusion partners (TFPs) capable of inducing expression or secretory production of non-producible proteins, which are difficult to produce in conventional recombinant production methods, from a variety of genetic sources, and protein secretion-inducing TFPs obtained using the method.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070275379 - Simian orl1 gene and method of assessing compound: A nucleic acid having a base sequence of SEQ ID NO. 1; a protein having an amino acid sequence of SEQ ID NO. 2; a recombinant vector comprising a gene constituted of the above nucleic acid; and a transformant cell comprising the recombinant vector. By the use of these, it... Agent: Merck And Co., Inc

20070275395 - Tagged monomers for use in sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070275376 - Tumor-specific expression of reporter genes: A reporter gene operably linked to a transcriptional control element that is up-regulated by a tumor-induced transcription factor is disclosed. This reporter gene construct can be used to detect tumor formation in vivo in an experimental animal.... Agent: Ropes & Gray LLP Patent Docketing 39/361

20070275401 - Use of mx gtpases in the prognosis and treatment of cancer: The invention provides a method of reducing cancer progression comprising administering a Mx polypeptide or Mx-encoding nucleic acid to a host, such that the growth rate of the cancer cells is reduced, the metastatic potential of the cancer cells is reduced, or both. The invention also provides a method of... Agent: Leydig, Voit & Mayer, Ltd.

20070275412 - Chondroitin sulfate binding proteins and modulators thereof: Chondroitin sulfate polysaccharides with defined sulfation patterns can be synthesized. These chondroitin polysaccharides can be used to identify chondroitin sulfate binding proteins. Further, compounds that modulate the activity of chondroitin sulfate binding proteins can be identified. For example, TNF-α was found to bind specifically to CS-E and CS-E can be... Agent: Knobbe Martens Olson & Bear LLP

20070275413 - Enumeration of cd4+lymphocytes: The invention provides a method of enumerating the number of cells of a cell type in a cell sample by (a) counting the white blood cells in the cell sample to obtain the white blood cell population of the sample; (b) determining the proportion or percentage of the cells of... Agent: Buchanan, Ingersoll & Rooney PC

20070275410 - Methods and compositions relating to modulation of gpcr signaling: The subject invention provides methods for detecting a GPCR-binding partner complex. In general, the methods involve co-producing two polypeptides, one of which being a GPCR, isolating one of the polypeptides using a substrate with affinity for that polypeptide, and directly detecting the presence of the other polypeptide on the substrate.... Agent: Arena Pharmaceuticals, Inc.

20070275409 - Methods for detecting and analyzing n-glycolynlneuraminic acid (neu5gc) in biological materials: The present application is in the field of sialic acid chemistry, metabolism and antigenicity. More particularly, the present invention relates to the detection and analysis of the non-human sialic acid, N-glycolylneuraminic acid (Neu5Gc) in bio-logical materials, such as food and clinical specimens. Such detection and analysis is facilitated by the... Agent: Axford Laurie Gorddon & Rees

20070275408 - Synthetic bioelastomer: A bioelastomer which is a polypeptide comprising a plurality of repeat units in which the consensus sequence SSXXYGXP, where S is serine, X is an unspecified amino acid, Y is tyrosine, G is glycine and P is proline, is present and which is cross-linked through dityrosine bond formation, with the... Agent: Sughrue Mion, PLLC

20070275417 - Cd4+ epitopes of bone morphogenetic proteins: The present invention provides CD4+ T-cell epitopes in bone morphogenetic proteins (BMPs). In particular embodiments, the present invention provides CD4+ T-cell epitopes of BMP-7 and BMP-14. In some preferred embodiments, the present invention provides CD4+ T-cell epitopes of BMP-7 and BMP-14 that are suitable for modification to reduce the immunogenicity... Agent: Kamrin T. Macknight Genencor International, Inc.

20070275418 - Monoclonal antibodies with specificity for fetal erythroid cells: The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.... Agent: Fulbright & Jaworski L.L.P.

20070275421 - Detection of dysplastic or neoplastic cells using anti-mcm2 antibodies: Determination of cellular growth abnormality, particularly cancerous abnormality, by detection of target polypeptides or encoding mRNA, where the target polypeptides are members of the preinitiation complex of DNA replication in tissue, cells or fluid. Target polypeptides include CDC6, MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7. Test samples include tissue of... Agent: Nixon & Vanderhye, PC

20070275420 - Method for detecting prognosis of cancer: It is to provide a method and a kit for detecting the prognosis of cancer at high accuracy in a simple and rapid manner at low cost. The method is specifically a method for detecting the prognosis of cancer, at least including a step of detecting core-2 β 1,6-acetylglucosaminyltransferase in... Agent: Sughrue Mion, PLLC

20070275422 - Methods and compositions for detecting pancreatic disease: Methods and compositions for at least determining whether a human subject has a pancreatic disease are provided. In practicing the subject methods, a sample from a subject is assayed for a pancreatic glycoprotein (GP2) analyte to determine whether the subject at least has the pancreatic disease. Also provided are kits,... Agent: Bozicevic, Field & Francis LLP

20070275419 - Tumor tag and the use thereof: The invention provides a new tumor tag, RL5 protein, the polynucleotide encoding RL5 protein, and the method of producing RL5 protein by recombinant technology. The invention also discloses the use of RL5 protein and the polynucleotides encoding RL5 protein, e.g., in diagnosing and treating tumor, as well as the pharmaceutical... Agent: Wilson Sonsini Goodrich & Rosati

20070275415 - Droplet-based affinity assays: The present invention relates to droplet-based affinity assays. According to one embodiment, a method of detecting a target analyte in a sample is provided, wherein the method includes: (a) executing droplet operations to combine affinity-based assay reagents on a droplet microactuator with a sample potentially comprising the target analyte to... Agent: Ward And Smith, P.A.

20070275414 - Method of detecting thrombosis by measuring von willenbrand factor-cleaving protease: A method of detecting thrombosis or the degree of thrombophilia by measuring a von Willebrand factor cleaving protease, and a kit for detecting thrombosis or the degree of thrombophilia, comprising an antibody or a fragment thereof specifically binding to a von Willebrand factor-cleaving protease, are disclosed. The detection method and... Agent: Heslin Rothenberg Farley & Mesiti PC

20070275416 - Affinity marker for purification of proteins: The present invention relates to an affinity marker comprising a FLAG-domain, which contains at least one FLAG-tag, and a Streptavidin-binding domain (Strep-domain), which contains at least two Strep-tags, a protein containing this affinity marker, a nucleic acid which codes for it, a vector or a cell containing the affinity marker,... Agent: Clark & Elbing LLP

20070275423 - Methods, peptides and biosensors useful for detecting a broad spectrum of bacteria: Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the α1-proteinase inhibitor. In the... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070275425 - Device and method for analysis of a metabolic malady: A method for detecting a metabolic malady in a subject, the method including: (a) measuring a quantitative feature of a lipid body disposed within a leukocyte derived from the subject, and (b) comparing the measurement obtained in step (a) with a threshold value, wherein if the measurement is significantly different... Agent: Pearl Cohen Zedek Latzer, LLP

20070275424 - Diagnostic tests and methods for diagnosing inflammatory bowel disease: Methods are disclosed for diagnosing inflammatory bowel disease (IBD), one exemplar method of which includes determining whether a sample is positive for anti-flagellin antibodies (AFA), diagnosing the presence of IBD when the sample is positive for AFA, and diagnosing the absence of IBD when the sample is negative for AFA.... Agent: Christopher B Linder Thomas Kayden Horstemeyer & Risley

20070275426 - Disk-like microfluidic structure for generating diffrent concentration fluid mixtures: A disk-like microfluidic structure includes a disk, and a plurality of microfluidic systems formed on the disk and covered by a top sealing layer. Each microfluidic system includes a first and a second supply chamber located near a geometrical center of the disk, and at least one receiving chamber communicably... Agent: Rosenberg, Klein & Lee

20070275427 - Method of detecting allergen: The present invention provides an immunological detection method that can detect milk allergens, allergens of albumen, flour, buckwheat and peanut with high sensitivity in foods containing these allergens regardless they are denatured/native, and a detection kit to be used therefor. It is a method for detecting allergens by using 2... Agent: Venable LLP

20070275429 - Method for measuring high density lipoprotein cholesterol: An object to be attained by the present invention is to provide a method for conveniently, rapidly, and specifically measuring HDL-C in a specimen by use of inexpensive materials, and to provide a reagent kit for HDL-C detection and a dry analytical element for HDL-C detection. The present invention provides... Agent: Birch Stewart Kolasch & Birch

20070275430 - Determining the concentration of analytes in sample by direct mediation of enzymes: The glucose content of blood can be determined by contacting a blood sample with a test strip containing a glucose dehydrogenase dependent on PQQ (or derivatives or isomers) thereof as a co-factor, a tetrazolium salt indicator, but in the absence of a mediator.... Agent: Nixon Peabody, LLP

20070275431 - Detection of preterm labour: The invention describes a method for diagnosis of preterm labour in a mammal, comprising measuring levels of an endocannabinoid such as anandamide in a subject. Elevated levels are indicate of preterm labour. The measurement is typically performed during late pregnancy, such as the third trimester in humans. In certain embodiments,... Agent: Wolf Greenfield & Sacks, P.C.

20070275432 - Means for a quantitative detection of cytochrome c: The invention relate to a method for detecting cytochrome c in a given biological sample, comprising: adding to said sample an efficient amount of two redox couples allowing for a cycling oxido-reduction of cytochrome c, said couples comprising an oxidizing agent consisting of cytochrome c oxidase enzyme and a reducing... Agent: Buchanan, Ingersoll & Rooney PC

20070275434 - Apoptosis-based evaluation of chemosensitivity in cancer patients: Induction of apoptosis in target cells is a key mechanism by which chemotherapy induces cell killing. An in vitro system has been established for determining carboplatin and paclitaxel (Taxol) chemosensitivity of epithelial ovarian cancer cells, where measurements of caspase-3 activation are surrogate markers for activation of chemotherapy-induced programmed cell death.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070275435 - Cell culture chip and method for real-time monitoring of a cell culture using the same: Disclosed herein are a cell culture chip for monitoring a cell culture in real time and a method of monitoring the cell culture using the cell culture chip. The cell culture chip includes a cell culture chamber formed by side walls of a non-conductive material and a bottom layer of... Agent: Cantor Colburn, LLP

20070275433 - Cells containing a nanopatch sensor in their membrane: The present invention provides isolated cells comprising nanopatch sensors integrated into the cell membrane thereof, wherein said sensors are provided in the form of perturbation-sensitive constructs, and wherein said perturbation-sensitive constructs respond to perturbations of the cell membrane by means of a detectable change in one or more physical or... Agent: Nixon & Vanderhye, PC

20070275437 - Antibodies to g protein-coupled receptor: A novel gene (designated PHOR-1) that is highly over-expressed in prostate and other cancers and its encoded protein are described. PHOR-1 is a G protein-coupled receptor with homology to receptors involved in olfaction. PHOR-1 in normal human tissues is restricted to prostate, and this gene is highly over-expressed in prostate... Agent: Morrison & Foerster LLP

20070275438 - Compositions and methods for producing fermentation products and residuals: The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the... Agent: Wilson Sonsini Goodrich & Rosati

20070275439 - Methods to obtain recombinant proteins with increased sialylation from cells that express adenovirus e1a protein, and proteins obtained thereby: The invention provides compositions comprising one or more isoforms of an erythropoietin (EPO) comprising glycans linked thereto, characterized in that said glycans comprise LewisX structures and on average at least 6 sialic acid moieties per EPO molecule. The invention further provides methods for obtaining a composition comprising one or more... Agent: Trask Britt

20070275436 - Polyene polyketides, processes for their production and their use as a pharmaceutical: This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells.... Agent: Merchant & Gould PC

20070275440 - Regulation of transcription factor, nf-il6/lap: An alteration in phosphorylation of serine 105, within the actvation domain of NF-IL6/LAP, alters its transcriptional efficacy. Potypeptides, polynucleotides and methods of use for modified transcriptional activators allow regulation of gene expression.... Agent: Lisa A. Haile, J.d., Ph.d. Gray Cary Ware & Freidenrich LLP

20070275441 - Ocular tissue modification: The present invention relates generally to the field of tissue modification, and in particular, but not exclusively, to methods of modifying cells of ocular and particularly corneal tissue to produce immunoglobulins or immunoglobulin fragments. The invention also relates to modified ocular cells and tissues, to expression vectors utilised in such... Agent: Seed Intellectual Property Law Group PLLC

20070275442 - Side chain deuterated amino acids methods of use: Protein structural determination using NMR techniques is improved through use of proteins in which one or more amino acids in the peptidic sequence are isotopically enriched in the sidechain with 2H and are isotopically enriched on the backbone with 13C, 15N, 2H or any combination thereof. This invention provides amino... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070275443 - Random drift mutagenesis: A method for producing a mutant gene encoding a functional gene product comprising: (a) introducing one or more mutations into a gene to form a mutated gene; (b) providing the mutated gene to a host microorganism; (c) culturing the host microorganism containing the mutated gene under conditions which allow expression... Agent: Knobbe Martens Olson & Bear LLP

20070275444 - Thermostable omega-transaminases: Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereoselectively one of a pair of chiral amines in which the amino group is bound... Agent: Banner & Witcoff, Ltd.

20070275445 - Process for the production and recovery of hydrocarbons: The invention is directed to a process for the production and recovery of chemicals, in particular hydrocarbons, from a fermentation medium, wherein solvent impregnated carriers are used. Accordingly, the invention provides a process for the production of hydrocarbon from a fermentation liquid comprising: forming said hydrocarbon from said fermentation liquid... Agent: Hoffmann & Baron, LLP

20070275446 - Biomass conversion performance using igneous phyllosilicate minerals with high emission of far-infrared light: The present invention relates to applications of far-infrared-inducing natural minerals to improve biomass conversion performance by promoting the growth of microbes, especially in the fermentation process. The present invention further relates to the enhancement of other enzyme reactions during the fermentation process. The present invention is applicable for use in... Agent: Drinker Biddle & Reath LLP Attn: Patent Docket Dept.

20070275447 - Indirect or direct fermentation of biomass to fuel alcohol: A novel clostridia bacterial species (Clostridium carboxidivorans, ATCC BAA-624, “P7”) is provided. P7 is capable of synthesizing, from waste gases, products which are useful as biofuel. In particular, P7 can convert CO to ethanol. Thus, this novel bacterium can transform waste gases (e.g. syngas and refinery wastes) into useful products.... Agent: Fellers Snider Blankenship Bailey & Tippens

20070275448 - Methods for obtaining optically active epoxides and vicinal diols from meso-epoxides: The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific meso-epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vectors containing such nucleic acid molecules, and cells containing such vectors. Also embraced by the invention are methods for obtaining... Agent: Fish & Richardson P.C.

20070275449 - Method for large-scale production, isolation, purification and the uses of multi-type recombinant adeno-associated virus vectors: The present invention relates to the method for production, isolation, purification and the uses of recombinant herpes simplex virus vectors loaded with five sero-type adeno-associated virus AAV1, 3, 4, 5 and 6 respectively. The above five sero-type recombinant herpes simplex viruses are HSV-r2c1, HSR-r2c3, HSV-r2c4, HSV-r2c6 respectively. The 1, 3,... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070275451 - Devices and methods for the selective isolation of microorganisms: Devices and methods for isolating and/or culturing microorganisms are provided. The devices comprise one or more semi-permeable membranes and may additionally include a growth medium for the microorganism. The devices and methods described herein can be used to isolate and culture both known and novel microorganisms from any environment.... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070275450 - Method for stabilization of biological cultures to allow biological treatment of brines: A process is disclosed for the biological treatment under anaerobic/anoxic conditions for the degradation of pollutants present in brine solution used in waste water management, in industrial waste brine solutions and in waste oil field brine solutions, especially waste brine solutions contaminated with perchlorate and nitrate. A culture capable of... Agent: Robert W Strozier, P.l.l.c

20070275452 - Biological reaction method and bioreactor: In a bioreactor, a culture solution derived from a cultivation tank is separated into bacteria cells and filtrate by a bacteria cell filter. The filtrate is introduced from the bacteria cell filter into a micro-nano bubble generation tank where micro-nano-bubbles are mixed with the filtrate. The filtrate containing micro-nano-bubbles is... Agent: Nixon & Vanderhye, PC

20070275453 - Method for the modification of polyacrylonitrile fibres containing vinyl acetate as a comonomer and polyamide fibres, using a cutinase enzyme: This invention relates a new enzymatic process for the modification of the surface of synthetic fibres using a cutinase enzyme (3.1.1.74). The enzymatic action causes the hydrolysis of the polyacrylonitrile fibres containing vinyl acetate as a comonomer and polyamide fibres, improving their hydrophilic characteristics and dyeing properties.... Agent: Sughrue Mion, PLLC

20070275454 - Electroporator having an elongated hollow member: An electroporation apparatus comprising an elongated hollow member in order to provide a uniform electric field during electroporation, wherein specifically, electroporation is carried out by applying electric pulses through a couple of electrodes from both end parts of the elongated hollow member, after the hollow member is charged with fluid... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070275455 - Valved, microwell cell-culture device and method: A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states... Agent: Perkins Coie LLP

20070275456 - Diagnostic testing apparatus: An apparatus for use in an assay process includes a pre-incubation chamber (10) defining a plurality of wells (14) having a porous base (18). The pre-incubation chamber (10) is attachable to a housing (12) carrying a porous membrane (32) disposed above and touching a body of absorbent material (36). A... Agent: Bozicevic, Field & Francis LLP

20070275457 - Cell culture surface chemistries: A surface supporting growth of cells in culture, the surface prepare to provide hydrophilic moieties exposed thereon for enhancing the attachment of biological materials. The surface contains the hydrophilic moiety as part of an amphipathic molecule also having a hydrophobic region that is anchored or embedded within a polymer substrate,... Agent: Wood, Herron & Evans, LLP

20070275458 - Three dimensional-bio-mimicking active scaffolds: The invention provides a Cellulose acetate (CA) thin, porous membranes produced by electrospinning precursor polymer solutions in acetone at room temperature and a process for manufacturing the same. The invention also provides a Cellulose acetate (CA) thin, porous membranes produced by electrospinning precursor polymer solutions in acetone at room temperature... Agent: Dilworth & Barrese, LLP

20070275460 - Fc variants with optimized fc receptor binding properties: The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.... Agent: Morgan, Lewis & Bockius, LLP

20070275459 - Method for preparing cell concentrate and cell composition: It is an object of the present invention to provide: a method for preparing a cell concentrate which efficiently separates nucleated cells from unnecessary cells contained in a cell-containing solution by simple operations, thereby reducing the volume of a solution used for cryopreservation that contains the nucleated cells, when the... Agent: Greenblum & Bernstein, P.L.C

20070275461 - Artificial dermis and method of preparation:

20070275462 - Human prostate cancer cell factor(s) that induce stem cell commitment and osteogenesis: Human prostate cancer (CaP) cells secrete biological activities that recruit cells to differentiate into the osteoblast lineage. Conditioned medium (CM) produced by metastatic human CaP cells (DuCaP and VCaP) induced commitment and differentiation of mesenchymal stem cells (MSC) into osteoblasts. CaP-CM induces cellular condensation into tissue-like aggregates. In turn, these... Agent: Fulbright & Jaworski L.L.P.

20070275463 - Serum-free media for chondrocytes and methods of use thereof: The present invention provides defined serum-free cell culture media useful in culturing fibroblasts, especially articular chondrocytes, that avoids problems inherent in the use of serum-containing media. The defined media comprise platelet-derived growth factor (PDGF), and chemically defined lipids, or combinations of these compounds. In another aspect, the present invention also... Agent: Genzyme Corporation Legal Department

20070275464 - Chitin oligosaccharide elicitor-binding proteins: The present inventors isolated and purified elicitor-binding proteins in good yield by combining the development of a column that uses APEA derivatives, pre-columns to remove non-specifically adsorbing substances, and effective elution methods. Using the N-terminal and internal chain amino acid sequences of the obtained proteins, the present inventors successfully isolated... Agent: Medlen & Carroll, LLP

20070275465 - Double-stranded ribonucleic acid with increased effectiveness in an organism: The invention concerns a method for the targeted selection of a double-stranded ribonucleic acid (dsRNA) consisting of two single strands that exhibits increased effectiveness in inhibiting the expression of a target gene by means of RNA interference, whereby the sequences of the single strands of the dsRNA are selected in... Agent: Foley Hoag, LLP

20070275466 - Methods of modifying genes in eukaryotic cells: Methods of creating mutations in genomic exons by inserting introns into the genomic exons via homologous recombination. Also, methods are provided for introducing modifications into genomic exons by inserting introns into the genomic exons via homologous recombination such that a mature mRNA transcript produced from a genomic region of the... Agent: Regeneron Pharmaceuticals, Inc

20070269796 - Microscope apparatus and cell observation method: The invention provides a microscope apparatus, used for identifying the cell phases of a plurality of cells mounted on a stage, including an analysis/observation optical system used for acquiring an observed-image of the cells and a stimulus optical system used for applying an optical stimulus to prescribed cells. Using these... Agent: Frishauf, Holtz, Goodman & Chick, PC

20070269809 - Estimation method, human estrogen receptor alpha gene, genomic dna, and diagnostic marker: e

20070269829 - Instrument and method for nucleic acid isolation: A nucleic acid isolation apparatus and method enables nucleic acid isolation from a nucleic-acid-containing sample quickly with high nucleic acid yield and purity. A nucleic acid isolation instrument 11 is supported by a stand 41 via a rib 19 (A). A solution is loaded into a first container 15 via... Agent: Mcdermott Will & Emery LLP

20070269819 - Method and apparatus for concentrating and amplifying nucleic acid in single micro chamber: A method of sequentially performing concentration and amplification of nucleic acid in a single micro chamber includes: introducing a nucleic acid-containing sample and a solution including a kosmotropic salt to a micro chamber having a hydrophilic interior surface to concentrate the nucleic acid by binding the nucleic acid on the... Agent: Cantor Colburn, LLP

20070269810 - Methods and compositions for detecting serotypes of chlamydia trachomatis capable of causing lymphogranuloma venereum: Disclosed are methods and compositions for conducting assays of samples utilizing polymerase chain reactions (“PCRs”) in the detection of serotypes of Chlamydia trachomatis capable of causing lymphogranuloma venereum (“LGV”). These serotypes are in the L group of Chlamydia trachomatis, and include the L I, L II, and L III serotypes.... Agent: Medical Diagnostic Laboratories LLC

20070269833 - Galectin-glycosaminoglycan complex and method for controlling galectin activity: A galectin-glycosaminoglycan complex and a method for controlling galectin activity.... Agent: Sughrue-265550

20070269837 - Devices and methods for fluorescent inspection and/or removal of material in a sample: An apparatus is provided that includes a light-emitting component, a light-detecting component, a lock-in amplifier, a frequency generator that is operatively linked to the lock-in amplifier and the light-emitting component, a speaker capable of emitting an audio signal wherein the output audio signal varies depending on the detected fluorescence in... Agent: James Mcgreevy

20070269840 - In-situ equilibrium dialysis: A method for the determination of analytes in samples using a pre-precipitated antibody complex. The complex includes an anti-analyte antibody and a secondary binding molecule that results in the precipitation of the antibody. Labeled-analyte analog competes for binding sites on the complex with analyte in the sample. The presence or... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070269850 - Elastomeric device for cell seeding on the bottom of a filter: An article is provided herein for use in seeding cells on at least one filter extending across at least one well of an assay device. The article includes an elastomeric body having spaced-apart first and second surfaces, and at least one channel extending between, and through the first and second... Agent: David W. Highet Vp & ChiefIPCounsel Becton, Dickinson And Company

20070269852 - Method and apparatus for detecting airborne pathogens using quantum dots: A method has been invented to detect and identify airborne pathogens and their properties based on the affinity of water-soluble quantum dot bioconjugates. A plurality of different sized quantum dot bioconjugates, where each size is conjugated with a different functional biological material or biomaterial, are combined in solution to form... Agent: James J. Muys

20070269789 - Bioreactor for producing a tissue prosthesis, particularly a heart valve: The invention relates to a bioreactor for producing a tissue prosthesis, particularly a heart valve, comprising a reactor chamber for holding a fluid nutrient medium and a prosthesis support, a device for placing the prosthesis support in the area of the reaction chamber, and a drive device for generating a... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070269792 - Cross-linked collagen matrix for producing a skin equivalent: A whole skin model is made by a process for the production of a whole skin model comprising the steps of: (a) providing a poorly soluble collagen obtained from collagen-containing tissue; (b) forming a homogeneous aqueous suspension by mixing the collagen with an aqueous medium; (c) forming a first matrix... Agent: Paul & Paul

20070269791 - Method of preparing isolated cell-free skin, cell-free dermal matrix, method of producing the same and composite cultured skin with the use of the cell-free dermal matrix: An object of the present invention is to provide a method for producing an ADM suitable as a scaffold for a cultured skin, that is, a separation and decellularization method that enables various types of extracellular matrixes such as a basement membrane to be preserved, allows the epidermal layer to... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070269790 - Methods of generating stem cells and embryonic bodies carrying disease-causing mutations and methods of using same for studying genetic disorders: Stem cells, stem cell lines and differentiated cells, tissues and organs which carry disease-causing mutations are provided. There is also provided a method of identifying agents suitable for treating disorders associated with at least one disease-causing mutations such as myotonic dystrophy and van Waardenburg syndrome.... Agent: Martin D. Moynihan Prtsi, Inc.

20070269793 - Bioactive boxes for cellular cultures: The invention relates to bioactive boxes for cellular cultures comprising a bilayer which is arranged on the bottom of said boxes and provided with an internal primary layer made of hydroxypropylmethylcellulose, or polyvinyl alcohol (PVA) and an external bioactive layer made of carboxypropylmethylcellulose. Said invention also relates to the use... Agent: Young & Thompson

20070269795 - Method for detecting the viability of trichuris suis eggs: A method for detecting the viability of Trichuris suis eggs by simulating in vitro a passage of the eggs through the gastrointestinal passage of a swine with regard to chronological sequence and medium. The method involves subjecting the eggs in vitro first to gastric simulation in gastric medium and then... Agent: Norris, Mclaughlin & Marcus, Pa

20070269794 - Screening method and screening apparatus using micro-chamber array: A method and apparatus for screening a microorganism or protein having a useful function by using a micro-chamber array. Using the screening method and screening apparatus in accordance with the present invention, a target protein having an enzymatic activity or a microorganism producing such a protein is screened from a... Agent: Drinker Biddle & Reath (dc)

20070269798 - Epitope-captured antibody display: Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is expressed from a heterologous nucleic acid borne by the package, and one or more antibodies complexed with the expressed... Agent: Townsend And Townsend And Crew, LLP

20070269797 - Method for analysis of the phenotypic characteristics of the human immunodeficiency virus (hiv): The present invention relates to a method for analyzing the phenotypic characteristics shown by certain virus strains, particularly human immunodeficiency viruses, involving the construction of a recombinant virus obtained by homologous recombination. The present invention also relates a kit comprising the primers, vectors, cell hosts, products and reagents required to... Agent: Hunton & Williams LLP Intellectual Property Department

20070269826 - Angular-dependent metal-enhanced fluorescence: The present invention relates to detection of fluorescence, and more particularly, to the use of fluorescent moieties in proximity to metallic surfaces to change the spatial distribution of fluorescence in an angular dependent manner and detecting emissions at a determined optimal detection angle thereby increasing sensitivity of the detection.... Agent: Marianne Fuierer Moore & Van Allen PLLC

20070269818 - Carbohydrate arrays: Methods of detecting a carbohydrate binding compound in a sample by providing a high density oligonucleotide array including a plurality of probe sequences, hybridizing a plurality of carbohydrates that include an oligonucleotide that is complementary to a probe sequence to the high density oligonucleotide array, hybridizing a sample including a... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070269828 - Compositions and methods for viral resistance genes: The present invention further provides a method of evaluating yellow fever virus susceptibility in a subject, which comprises obtaining a nucleic acid containing at least a portion of OAS gene from the subject, and determining whether the nucleic acid comprises SNPs relating to the susceptibility of the subject to yellow... Agent: Troutman Sanders LLP

20070269804 - Computer system and methods for constructing biological classifiers and uses thereof: The present invention provides systems and method for constructing classifiers that distinguish between trait subgroups using molecular marker data from blood samples. The invention further encompasses the use of the classifiers and combinations of molecular markers identified by the classifiers in a wide variety of applications including: diagnosis; prognosis; prediction... Agent: Jones Day

20070269823 - Detection and quality control of regulatory t cells through dna-methylation analysis of the foxp3 gene: The present invention relates to a method, in particular an in vitro method for identifying FoxP3-positive regulatory T cells, preferably CD25+CD4+ regulatory T cells of a mammal, comprising analysing the methylation status of at least one CpG position in the gene foxp3 or an orthologous or paralogous gene thereof, and... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070269822 - Detection of contaminating dna via apmplification of sequences of less than 100 bp: The present invention provides methods, compositions and kits for amplifying, measuring, and/or detecting contaminating DNA (e.g., ruminant and non-ruminant) in samples by amplification and/or detection of a target DNA of less than 100 base pairs in the samples.... Agent: Townsend And Townsend And Crew, LLP

20070269800 - Diagnostic and therapeutic use of foap-13 polynucleotides and polypeptides for neurodegenerative diseases: The present invention discloses the dysregulation of foap-13 gene expression in specific brain regions of Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing or prognosticating Alzheimer's disease in a subject, or for determining whether a subject is at increased risk of developing Alzheimer's disease.... Agent: Venable LLP

20070269807 - Diagnostics and therapeutics for diseases associated with putative cysteine protease 1 (prs1): The invention provides a human PRSC1 which is associated with the cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer,... Agent: Banner & Witcoff, Ltd.

20070269803 - Fluorogenic nucleic acid probes including lna for methods to detect and/or quantify nucleic acid analytes: The present invention relates to novel methods for detecting or quantifying nucleic acid analytes through their interactions with a nucleic acid probe or a pair of nucleic acid probes, wherein the probe or the pair of probes is comprised of at least one monomeric LNA moiety and two or more... Agent: Sigma-aldrich Co.

20070269821 - Lateral flow devices: An analytical test for an analyte comprises (a) a base, having a reaction area and a visualization area, (b) a capture species, on the base in the visualization area, comprising nucleic acid, and (c) analysis chemistry reagents, on the base in the reaction area. The analysis chemistry reagents comprise (i)... Agent: Evan Law Group LLC

20070269825 - Method and kit for nucleic acid sequence detection: A method and kit for detecting the presence of a target sequence in a polynucleotide analyte contained in a sample are disclosed. In practicing the method, the sample is mixed with a target probe having a sequence capable of hybridizing with said target sequence, under conditions effective to form a... Agent: Youxiang Wang

20070269814 - Method of pathogen or chemical detection: A method of determining the presence and level of microorganisms and/or chemicals in samples taken from generally any non-laboratory substance or environment. The method preferably comprises one or a combination of the steps of (a) prescreening for threshold levels of targeted microorganisms and/or (b) confirming the presence of targeted microorganisms... Agent: Fellers Snider Blankenship Bailey & Tippens

20070269813 - Methods and arrays for identifying human microflora: The present invention relates to a human microflora identification array. In particular, the present invention involves methods for identifying microorganisms, assessing microflora, diagnosing disease, providing a prognosis, and determining the efficacy of treatment, using one or more nucleic acid molecules having a sequence of SEQ ID NO: 1-585. The method... Agent: Antoinette G. Giugliano, P.C.

20070269824 - Methods and systems for evaluating health risk factors by measurement of dna damage and dna repair: Disclosed are methods for measuring the effects of environmental, physiological, or lifestyle variables on DNA damage and DNA repair activity as well as the use of measurements of DNA damage and DNA repair activity to predict increased risk for disease. Embodiments of the methods involve the use of a combination... Agent: Kilpatrick Stockton LLP

20070269817 - Methods for genotyping: The present invention provides for methods for discriminating between alleles at polymorphic positions in a genome. In general the methods employ allele specific extension of oligonucleotides that are complementary to one of the alleles at the 3′ end of the oligonucleotide. The allele specific oligonucleotides are resistant to proof reading... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070269820 - Methods for the detection of nucleic acid encoding alpha-amylase: The present invention is drawn to methods and compositions for the detection and/or quantification of nucleic acid encoding α-amylase in a sample. Provided herein are novel primer and probe compositions for use in detecting the presence of α-amylase in an organism, particularly using quantitative PCR methods. Provided herein are novel... Agent: Alston & Bird LLP

20070269801 - Multiplexed methylation detection methods: The present invention is directed to sensitive and accurate multiplexed assays for target analyte detection and detection of methylation in nucleic acid samples.... Agent: Mcdermott, Will & Emery

20070269815 - Multitargeting interfering rnas having two active strands and methods for their design and use: Interfering RNA molecules are now designed and produced with specificity for multiple binding sequences present in distinct genetic contexts in one or more pre-selected target RNA molecules and are used to modulate expression of the target sequences. The multitargeting interfering RNA molecules have two strands that target multiple target sites... Agent: Philip S. Johnson Johnson & Johnson

20070269816 - Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance: The present invention is directed to the field of nucleic acid diagnostics and the identification of base variation in target nucleic acid sequences. More particularly, the present invention relates to the use of such genotypic characterization of a target population of HIV and the subsequent association, i.e., correlation, of this... Agent: Philip S. Johnson Johnson & Johnson

20070269799 - Nucleic acid amplification methods: The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention further relates to methods for general amplification of genomic DNA and total mRNAs and for analyzing differential mRNA expression using... Agent: Steven B. Pokotilow, Esq. Stroock & Stroock & Lavan LLP

20070269805 - Ola-based methods for the detection of target nucleic avid sequences: Method for the detection of a target sequence comprising ligating two probes when annealed adjacent to the target sequence, hybridisation of a compound primer to the ligated probes and after elongation of the compound primer, amplifying the elongated compound primer from primers annealing to primer binding sites provided in the... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070269806 - Polynucleotide arrays: The invention provides a hairpin polynucleotide, having a loop and a stem region, characterised in that a sulfur-based nucleophile is attached to an internal nucleotide in the hairpin through a linker to enable binding to a solid support.... Agent: Klauber & Jackson

20070269827 - Predicting and diagnosing patients with autoimmune disease: The present invention provides methods for the prediction and diagnosis of autoimmune diseases including Systemic Lupus Erythematosus using a panel of single nucleotide polymorphisms (SNPs).... Agent: Fulbright & Jaworski L.L.P.

20070269802 - Ranbp2 as modifiers of the pten/igf pathway and methods of use: Human RANBP2 genes are identified as modulators of the PTEN/IGF pathway, and thus are therapeutic targets for disorders associated with defective PTEN/IGF function. Methods for identifying modulators of FEN/IGF, comprising screening for agents that modulate the activity of RANBP2 are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20070269811 - Superoxide dismutase (sod) gene and a method of identifying and cloning thereof: The present invention provides a superoxide dismutase gene from Potentilla atrosanguinea, a construct containing the gene coding for superoxide dismutase and transformed E.coli producing the SOD protein.... Agent: Edwards Angell Palmer & Dodge LLP

20070269812 - System for detecting protease: Disclosed is a system for detecting a protease inside a cell. In one embodiment, the system includes a chimeric protein that comprises as covalently linked components: 1) at least one optionally masked signal protein; 2) at least one protease-specific cleavage site; and 3) at least one detectable amino acid sequence.... Agent: Fish & Richardson PC

20070269808 - Wnt receptor compositions and methods: Wnt receptor compositions and methods of use are disclosed. In particular, methods using Wnt receptors, such as Dfz2, in screens for compounds which modulate the binding of a Wnt polypeptide to a Wnt receptor.... Agent: Ropes & Gray LLP Patent Docketing 39/41

20070269831 - Method for early detection of ovarian cancer: YKL-40 levels in serum and plasma samples provide as an indicator of both the presence of early stage ovarian cancer and of its aggressiveness. Thus testing for YKL-40 levels in patients at risk but not yet displaying symptoms associated with ovarian cancer, or in patients newly diagnosed with early stage... Agent: Marina Larson & Associates, LLC

20070269834 - Methods and compositions for development of drug screening procedures and diagnostic tools: This invention defines novel research and clinical laboratory methodology and compositions related thereto appropriate for use in (a) determining the presence of a neurodegenerative disease selected from the group limited solely to Charcot-Marie-Tooth disease, familial Alzheimer's disease, familial Parkinson's disease, Huntington's disease, spinal muscular atrophy, Friedreich'a ataxia, giant axon neuropathy,... Agent: Howard K. Shapiro, Ph.d.

20070269832 - Novel affinity labels: wherein L, A, X, and R′ have any of the values defined in the specification, or salts thereof, as well as compositions comprising such compounds or salts. The composition of the amino acid side-chain (R′) along with the amino acid or amino acid sequence (peptide) of the X component of... Agent: Schwegman, Lundberg & Woessner, P.A.

20070269830 - Process for the identification of new medical targets: The present invention relates to a process for the isolation and identification of pharmaceutically relevant target compounds (TC) from a sample, said sample being derived from a living organism, wherein said target compound(s) bind(s) to a compound of interest (COI) under physiological conditions, said compound of interest (COI) being associated... Agent: Clark & Elbing LLP

20070269835 - Reagent for determining laminin 5 antigen in biological sample and assay method: A method of determining a laminin 5 antigen in a biological sample, comprising the steps of bringing an antibody reactive to a laminin 5 γ2 chain N-terminal fragment into contact with the biological sample; measuring a reaction of the antibody; and determining an amount of the laminin 5 antigen based... Agent: Choate, Hall & Stewart LLP

20070269838 - Method for whole surrounding surface display of target proteins using bacterial exoporium: The present invention relates to a method for expressing a target protein on an exosporium forming the outermost surface of bacterial spores. More particularly, the present invention relates to a method for expressing a target protein on the surface of cells and spores using an exosporium as a matrix for... Agent: Intellectual Property / Technology Law

20070269839 - Preparation of spheres for diagnostic tests: The invention relates to surfactant-free reagent spheres useful for biological tests particularly those involving antigen/antibody reactions.... Agent: Klauber & Jackson

20070269836 - Methods and compositions for the diagnosis of venous thromboembolic disease: The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out venous thromboembolic disease, pulmonary embolism, and/or deep vein thrombosis, and for risk stratification in such... Agent: Foley & Lardner LLP

20070269841 - Determination of concentration of fk778 by competitive immunoassay: Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to... Agent: Robert Deberardine Abbott Laboratories

20070269842 - Assay for acetyltransferases and acetyltransferase substrates: Methods of identifying an acetyltransferase substrate in a sample are provided. Also provided are methods of localizing acetylation of an acetyltransferase substrate in a cell. Additionally, methods of labeling a protein substrate of an acetyltransferase are provided, as are methods of assaying an acetyltransferase in a sample. Methods of quantifying... Agent: Amster, Rothstein & Ebenstein LLP

20070269843 - Diagnostic assays that use mycobacteriophages: The present invention provides a method for a rapid and efficient mycobacteriophage-based diagnostic assay for the presence of microbacteria that have mycolic-acid structures in their outer membranes, such as mycobacteria, using betaine-like detergents.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070269844 - Novel assay for inositol phosphorylceramide synthase activity: Disclosed is a simple and reproducible method for assaying inositol phosphorylceramide synthase activity that employs a fluorescence resonance energy transfer pair for measuring enzyme activity. The invention also includes a novel method for identifying IPC synthase inhibitors.... Agent: Jonathan P. O'brien

20070269845 - Method of generating and isolating tumour cells: The invention provides a method of generating and isolating cells of a defined tumour phenotype being invasive and angiogenesis-independent (phenotype I), from a tumour sample, said method comprising the steps of culturing tumour cells of said tumour sample for up to nine days in order to establish multicellular spheroids, and... Agent: Seed Intellectual Property Law Group PLLC

20070269847 - Methods, pharmaceutical formulations and kits for identification of subjects at risk for cancer: Subjects at risk for developing cancer may be identified by obtaining samples of diagnostic cells from the subjects and determining a measure of cytotoxicity of the cells, the measure of cytotoxicity correlating negatively with the risk of developing cancer. The development of cancer may be prevented in subjects determined to... Agent: Alston & Bird LLP

20070269846 - Organic cation transporter preferentially expressed in hematopoietic cells and leukemias and uses thereof: A novel organic cation transporter (OCT) gene, OCT 6, and use thereof is described. The OCT6 gene is preferentially expressed in human hematopoietic tissues, including CD34+ cells and leukemia cells. Its narrow tissue distribution, substrate specificity, and close homology to other cell membrane transporters make OCT6 an attractive target for... Agent: Mcdermott Will & Emery LLP

20070269849 - Air sampling method, device and system for microbiological analysis: A method of using an air suction device is provided having a device equipped with a removable sampling head that is replaced between each sampling operation. Inside the head is a Petri dish containing a culture medium. Air is sucked through the head in order to impact on the culture... Agent: Young & Thompson

20070269848 - Liquid crystalline substrates for culturing cells: The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells.... Agent: Godfrey & Kahn, S.c.

20070269851 - Colorimetric substrates, colorimetric sensors, and methods of use: Described herein is a substrate comprising at least one colorimetric component attached to a peptide, as well as methods for detecting a modification of said substrate. Also described are methods of detecting the presence or absence of a protein, for example, a protein produced by a microorganism, by contacting a... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070269853 - Integrated device for diagnostic analyses, and relative method: An integrated device for diagnostic analyses used to verify the presence of bacteria in at least a biological sample mixed with a eugonic culture broth, in order to identify the type of bacteria, and to test a series of antibiotics, identifying those effective to determine the antibiotic therapy. The device... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20070269854 - Method and device for measuring an enzymatic activity in a body fluid: The invention concerns a method and a device for measuring an enzymatic activity in a body fluid. The method comprises the following steps: a) providing a support having a conductive surface whereon is immobilized a substrate specific of the enzymatic activity to be measured, the substrate comprising an electroactive residue;... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070269855 - Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthases and accessory proteins, and uses thereof: The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.... Agent: Townsend And Townsend And Crew, LLP

20070269856 - Viral purification methods: The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filtration and column chromatography. Viruses and... Agent: Fish & Richardson P.C.

20070269857 - A process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and... Agent: Fitzpatrick Cella Harper & Scinto

20070269858 - Combinatorial biology: The present invention provides a method for merging combinatorial biosynthesis with techniques of synthetic organic chemistry. In general, this method, combinatorial biology, involves 1) providing “starter units”, wherein the starter units are capable of being accepted by the modular biosynthetic enzymatic machinery, and have incorporated therein a “functional handle” capable... Agent: Choate, Hall & Stewart LLP

20070269864 - Designer proton-channel transgenic algae for photobiological hydrogen production: A designer proton-channel transgenic alga for photobiological hydrogen production that is specifically designed for production of molecular hydrogen (H2) through photosynthetic water splitting. The designer transgenic alga includes proton-conductive channels that are expressed to produce such uncoupler proteins in an amount sufficient to increase the algal H2 productivity. In one... Agent: Knox Patents

20070269862 - Installation of genomes or partial genomes into cells or cell-like systems: A method is provided for introducing a genome into a cell or cell-like system. The introduced genome may occur in nature, be manmade with or without automation, or may be a hybrid of naturally occurring and manmade materials. The genome is obtained outside of a cell with minimal damage. Materials... Agent: Carr & Ferrell LLP

20070269866 - Methods and compositions for producing vitamin k dependent proteins: The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells.... Agent: Myers Bigel Sibley & Sajovec

20070269860 - Modified sarcosine oxidases, genes and recombinant dnas thereof, and methods for preparing the same: (1) A modified sarcosine oxidase with improved stability in the acidic range compared to a wild-type sarcosine oxidase. (2) A sarcosine oxidase gene encoding a modified sarcosine oxidase of the following (a), (b), or (c): (a) protein composed of the amino acid sequence represented by SEQ ID NO: 1 (b)... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070269859 - Plant sterol acyltransferases: The present invention is directed to lecithin:cholesterol acyltransferase-like polypeptides (LCAT) and acyl CoA:cholesterol acyltransferases-like polypeptides (ACAT). The invention provides polynucleotides encoding such cholesterol:acyltransferases-like polypeptides, polypeptides encoded by such polynucleotides, and the use of such polynucleotides to alter sterol composition and oil production in plants and host cells. Also provided are... Agent: Fulbright & Jaworski, L.L.P.

20070269863 - Process for the production of preformed conjugates of albumin and a therapeutic agent: The present invention provides processes for the production of preformed albumin conjugates. In particular, the invention provides processes for the in-vitro conjugation of a therapeutic compound to recombinant albumin, wherein a therapeutic compound comprising a reactive group is contacted to recombinant albumin in solution to form a conjugate. The processes... Agent: Jones Day

20070269865 - Recombinant fragments of the human acetylcholine receptor and their use for treatment of myasthenia gravis: Polypeptides capable of modulating the autoimmune response of an individual to human acetylcholine receptor (hAChR), more particularly polypeptides corresponding entirely or partially to the extracellular domain of hAChR α-subunit, are useful in the diagnosis and treatment of myasthenia gravis. Preferred polypeptides are polypeptides corresponding to amino acid residues 1-121 or... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070269861 - Soluble recombinant botulinum toxin proteins: The present invention includes recombinant proteins derived from Clostridium botulinum toxins. In particular, soluble recombinant Clostridium botulinum type A, type B and type E toxin proteins are provided. Methods which allow for the isolation of recombinant proteins free of significant endotoxin contamination are provided. The soluble, endotoxin-free recombinant proteins are... Agent: Stout, Uxa, Buyan & Mullins LLP

20070269867 - Protein markers associated with bone marrow stem cell differentiation into early progenitor dendritic cells: A novel cytosolic 58 kd phosphoprotein induced during bone marrow stem cell (BMS) differentiation into dendritic cells (DC) during in vitro cultivation with the cytokine GM-CSF by addition of antisera to an 82 kd BM cell surface protein generating cultivatable dendritic progenitor cells (DP). Genes, methods for preparing them as... Agent: Edward T. Lentz

20070269868 - Culture method for obtaining a clonal population of antigen-specific b cells: The present invention relates to methods of isolating antigen-specific cells and producing antibodies therefrom.... Agent: Hunton & Williams LLP Intellectual Property Department

20070269869 - Carotene synthase gene and uses therefor: Described herein is a novel three domain gene from Schizochytrium, denoted carotene synthase, that encodes a protein with three different enzymatic activities: phytoene dehydrogenase (PD), phytoene synthase (PS), and lycopene cyclase (LC). Also described is the isolated gene encoding the carotene synthase, homologues thereof, the enzyme encoded by such gene,... Agent: Sheridan Ross PC

20070269870 - Methods for assembly of high fidelity synthetic polynucleotides: Disclosed are methods of manufacturing synthetic DNAs, that is, DNAs made at least in significant part by chemical synthesis of nucleic acid polymers. Also provided are methods for assembling plural DNAs in the same pool by multiplexed assembly of synthetic oligonucleotides. In exemplary embodiments, the methods involve pre-amplification of one... Agent: Ropes & Gray LLP Patent Docketing 39/41

20070269871 - Pef-ts expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP

20070269872 - Recombinant coryneform bacterium and method for producing diodegradable polyester: A recombinant coryneform bacterium obtained by providing a coryneform bacterium, which is known as a safe substance originally having no hazardous endotoxin, includes membrane structures different from E. coli and can be cultured in high density, with a biodegradable polyester producing ability, and a method for efficiently producing a biodegradable... Agent: Quinn Emanuel Koda & Androlia

20070269873 - Ethanol process using pre-fermentation solids removal: A process for preparing a starch-containing biomass particle stream having a significant percentage of fiber for processing into ethanol comprises the first step of: mixing the particle stream with a liquid solvent to dissolve at least a portion of the starch in the carbohydrate particle stream to form a carbohydrate... Agent: Nawrocki, Rooney & Sivertson Suite 401, Broadway Place East

20070269874 - Multi-stage microbial system for continous hydrogen production: A method of using sequential chemostat culture vessels to provide continuous H2 production, in which photosynthetic O2 evolution and H2 photoproduction are separated physically into two separate bioreactors, comprising: a) growing a microorganism culture able to continuously generate H2 by photosynthetically producing cells at about the early-to-late log state in... Agent: Paul J White Nrel

20070269875 - Method and apparatus for cell permeabilization: The invention relates to methods and apparatuses for introducing and releasing substances into and out of cells, and more specifically to methods and apparatuses for transiently permeabilizing a living cell so that any one or more of a variety of substances, such as ions, proteins, and nucleic acids, can be... Agent: Knobbe Martens Olson & Bear LLP

20070269876 - Device and process for treating a liquid medium: A device for treating liquid medium has an ultrasound emitter located relative to a compartment of a container holding a liquid medium and a microbubble emitter located relative to the compartment. The ultrasound emitter emits high-frequency ultrasound between about 200 KHz and 10 MHz. The microbubble emitter emits bubbles with... Agent: Knobbe Martens Olson & Bear LLP

20070269878 - Compositions and methods for reverse transcription of nucleic acid molecules: The present invention is generally related to compositions and methods for the reverse transcription of nucleic acid molecules, especially messenger RNA molecules. Specifically, the invention relates to compositions comprising mixtures of polypeptides having reverse transcriptase (RT) activity, and to methods of producing, amplifying or sequencing nucleic acid molecules (particularly cDNA... Agent: Invitrogen Corporation C/o Intellevate

20070269877 - Dna polymerases: The present invention relates to a variant archaeal DNA polymerase comprising a modified amino acid sequence of a wild-type amino acid sequence, wherein during DNA replication, the variant polymerase is adapted to mis-incorporate a greater number of incorrect bases than compared to a wild-type archaeal DNA polymerase. Such a variant... Agent: Pillsbury Winthrop Shaw Pittman LLP

20070269879 - Methods of refolding mammalian glycosyltranferases: The present invention provides methods of refolding mammalian glycosyltransferases that have been produced in bacterial cells, and methods to use such refolded glycosyltransferases, including glycosyltransferase mutants that have enhanced ability to be refolded. The invention also provides methods of refolding more than one glycosyltransferase in a single vessel, methods to... Agent: Townsend And Townsend And Crew, LLP

20070269880 - Stabilizing solutions for submicronic particles, methods for making the same and methods of stabilizing submicronic particles: Stabilizing solutions for submicronic particles, methods for making the same and methods of stabilizing submicronic particles is disclosed.... Agent: Hedman & Costigan P.C.

20070269881 - Carotene synthase gene and uses therefor: Described herein is a novel three domain gene from Schizochytrium, denoted carotene synthase, that encodes a protein with three different enzymatic activities: phytoene dehydrogenase (PD), phytoene synthase (PS), and lycopene cyclase (LC). Also described is the isolated gene encoding the carotene synthase, homologues thereof, the enzyme encoded by such gene,... Agent: Sheridan Ross PC

20070269882 - Liquid volumetric device and method: The present invention discloses a liquid volumetric device comprising a metering tube, a start sensor, an end sensor, a bath for storage of a sample to be metered, a vacuum chamber and a pump for pumping out air inside the vacuum chamber to form a negative pressure inside the vacuum... Agent: Workman Nydegger

20070269883 - Micropatterning surfaces: The present invention is directed to a method for preparing a surface having a pre-selected ink pattern.... Agent: Viksnins Harris & Padys Pllp

20070269884 - Live bacteria liquid product applicator: An applicator for applying a liquid carrier having live bacteria suspended therein, which are in a dormant state, to a target host comprising a pump having inlet and discharge sides, with the inlet side of the pump being in fluid communication with the liquid carrier. A first fluid conduit extends... Agent: Thomte Law Office, L.L.C.

20070269885 - Method for producing dendritic cells: Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells made be produced by a method comprising the steps of providing a population of embryonic stem cells; culturing the embryonic... Agent: Bozicevic, Field & Francis LLP

20070269886 - Extracellular matrix coated surface for culturing cells: A cell culture product is provided for propagating embryonic stem cells, and maintaining their self-renewal and pluripotency characteristics for extended periods of time in culture. The cell culturing, product includes a substrate; and a coating thereon deposited, from a coating solution. The coating solution includes a mixture of extracellular matrix... Agent: David W. Highet Vp & ChiefIPCounsel Becton, Dickinson And Company

20070269887 - Stem and progenitor cell compositions recovered from bone marrow or cord blood; system and method for preparation thereof: The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and... Agent: Audrey A. Millemann Weintraub Genshlea Chediak

20070269888 - Bioreactor assembly comprising at least one tray-like rocking platform: The present invention relates to a bioreactor assembly comprising a reactor frame that permits linear upscaling under identical conditions of culture volumes from two liters to thousands of liters. The bioreactor comprises at least one rocking platforms being capable of holding at least one disposable bag adapted for receiving a... Agent: Nixon & Vanderhye, PC

20070269890 - Compositions of active wnt protein: Compositions of purified biologically active Wnt proteins are provided. Wnt proteins are found to be hydrophobic and post-translationally modified by addition of a lipid moiety at a conserved cysteine residue. Methods for isolation of Wnt utilize detergents that maintain the solubility of the modified protein.... Agent: Bozicevic, Field & Francis LLP

20070269889 - Stabilized sirnas as transfection controls and silencing reagents: RNA molecules, including siRNA molecules and related control, trackability and exaequo agents with specific stability modifications are provided. These molecules are particularly advantageous as transfection control reagents. The molecules include first and second 5′ terminal sense nucleotides with 2′-O-alkyl groups and a label on the first 5′ terminal sense nucleotide,... Agent: Workman Nydegger

20070269892 - Formulations for intracellular delivery dsrna: What is described is a composition for delivery of a RNA molecule to a cell, comprising: a double stranded RNA (dsRNA) molecule of about 15 to about 40 base pairs; and a cationic polymer peptide comprising at least two cysteine residues and at least one tryptophan residues with one or... Agent: Nastech Pharmaceutical Company Inc

20070269891 - Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells: A cell transfection/culture device is disclosed which includes a solid support coated with a degradable polymer cation as a transfection reagent. The transfection/culture device is conveniently stored at room temperature until use. Cell transfection is accomplished easily by adding the nucleic acid of interest and the cells to be transfected... Agent: Knobbe Martens Olson & Bear LLP

20070264626 - Apparatus and method for a combination of ablative and nonablative dermatological treatment: The invention describes a treatment for skin wherein a pattern of holes is ablated in a selected region of skin tissue using an optical source. Substantially nonablative energy is delivered to the selected region to at least two holes in the pattern to thermally heat a target in or just... Agent: Reliant / Fenwick C/o Fenwick & West, LLP

20070264625 - Apparatus and method for ablation-related dermatological treatment of selected targets: The invention describes a treatment for skin containing selected targets that provides feedback in response to a measurement enabled by the ablation of holes. The inventive apparatus includes an electromagnetic source configured to emit ablative electromagnetic energy, a delivery system, a sensing element, and a controller. The delivery system can... Agent: Reliant / Fenwick C/o Fenwick & West, LLP

20070264628 - Phase transition type valve and method of manufacturing the same: A phase transition type valve is provided. The valve includes a phase transition material filled and hardened in a section of a channel and a tube expanding region which has a larger cross-sectional area than the channel formed at both ends of the section in which the phase transition material... Agent: Sughrue Mion, PLLC

20070264629 - Real-time detection of influenza virus: The present invention provides system and methods for detecting an analyte indicative of an influenza viral infection in a sample of bodily fluid. The present invention also provides for systems and method for detection a plurality of analytes, at least two of which are indicative of an influenza viral infection... Agent: Wilson Sonsini Goodrich & Rosati

20070264640 - Array-based assays using split-probe nucleic acid arrays: Methods and compositions for performing array-based assays of a nucleic acid sample, such as genomic sample assays, e.g., comparative genomic (aCGH) assays, are provided. Aspects of the invention include arrays containing split-probe nucleic acids that include two linked domains that flank a nucleic acid region, such as a genomic region,... Agent: Agilent Technologies Inc.

20070264658 - Compositions and methods to detect enterococci nucleic acid: The disclosed invention includes nucleic acid oligomers that may be used as amplification oligomers, including primers, capture probes for sample preparation, and detection probes for detection of indicator enterococci 23S rRNA sequences in samples by using methods of specific nucleic acid amplification and detection.... Agent: Gen Probe Incorporated

20070264659 - Lung cancer biomarker discovery: The present application discloses an epigenetic marker for lung cancer.... Agent: Joseph Hyosuk Kim Jhk Law

20070264656 - Method of manufacturing probe-immobilized carrier: A probe-immobilized carrier in which a probe capable of specifically binding to a target is immobilized on a substrate is manufactured by a method comprising the steps of: (1) coating the substrate with a reactive substance having a reactive group for immobilizing the probe on the substrate; (2) applying the... Agent: Fitzpatrick Cella Harper & Scinto

20070264664 - Nonseparation assay methods: Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support as is a member of a specific binding pair for capturing an analyte from a sample. An activator compound that activates the chemiluminescent... Agent: Nexgen Diagnostics, LLC

20070264655 - Nucleic acid automatic examining device: A nucleic acid automatic examining device implements a hybridization reaction step after implementing a nucleic acid amplification reaction step on a nucleic acid sample containing a target nucleic acid. The device includes a nucleic acid amplification unit, a hybridization reaction unit, a dispenser unit for moving the nucleic acid sample... Agent: Fitzpatrick Cella Harper & Scinto

20070264657 - Nucleic acids for detecting b-cell malignancy: This document provides methods and materials related to detecting gene rearrangements (e.g., MYC gene rearrangements). For example, nucleic acid probe sets for detecting MYC-immunoglobulin gene rearrangements in mammals are provided.... Agent: Fish & Richardson P.C.

20070264677 - Methods, systems and computer programs for assessing chd risk using adjusted hdl particle number measurements: Methods, computer program products and apparatus determine a subject's risk of having or developing CHD using a calculated HDL particle risk number and/or a mathematical model of risk associated with HDL particles that adjusts concentrations of at least one of the subclasses of small, medium and large HDL particle measurements... Agent: Myers Bigel Sibley & Sajovec

20070264683 - Process challenge device for a high-pressure steam sterilizer and sheet for a challenge device: A process challenge device 1 for a high-pressure steam sterilizer, includes a plurality of stacked steam permeable bodies 7, 8, and 9 formed by a material capable of permeating of steam 11 and an indicator 10. The steam permeable bodies 8 (except the steam permeable bodies 7 and 9 arranged... Agent: Wood, Phillips, Katz, Clark & Mortimer

20070264691 - Optimization of coronatine production in a genetically improved strain of pseudomonas syringae: Stable genetically engineered bacterial strains that overproduce coronatine are provided. The stable strains can be successfully cultivated to overproduce coronatine at temperatures that are suitable for large scale, commercial preparations of coronatine. The overproducing strains are also non-pathogenic. An exemplary strain is Pseudomonas syringae APV1, which successfully overproduces coronatine at... Agent: Fellers Snider Blankenship Bailey & Tippens

20070264624 - Method for determining activity of cell cycle regulatory factor and method for diagnosing cancer using the same: A method for determining the activity of a cell cycle regulatory factor comprising the steps of preparing a sample for measuring a cyclin-dependent kinase/cyclin complex from living cells; reacting adenosine 5′-O-(3-thiotriphosphate) (ATP-γ S) with a substrate for the cyclin-dependent kinase in presence of the sample in order to introduce a... Agent: Birch Stewart Kolasch & Birch

20070264623 - Nanosensors: The present invention generally relates to nanoscale wires for use in determining analytes suspected to be present in a sample, especially in connection with determining information about a sample containing, or suspected of containing, two or more analytes. For example, the invention can involve a competitive, uncompetitive, or non-competitive binding... Agent: Wolf Greenfield & Sacks, P.C.

20070264627 - Retrovirus from the hiv group and its use: A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070264637 - 11q deletion as a molecular genetic marker in breast cancer: The present invention relates to methods for predicting sensitivity and response to a chemotherapy in a patient suffering from breast cancer based on the detection of the presence or absence of a deletion in the human chromosome region 11q21-q25 in a breast tumor sample from said patient.... Agent: Moore & Van Allen PLLC

20070264636 - Capture and random amplification protocol for identification and monitoring of microbial diversity: Sequence capture and random amplification are used to generate a population of polynucleotides that reflect the sequence diversity of a starting microbial population. The CAPRA population is used in hybridization reactions for the assessment of diversity and for the quantitation of particular members in the starting population. The polynucleotide population... Agent: Bozicevic, Field & Francis LLP

20070264643 - Compositions and methods relating to cns lymphoma: Compositions, methods and kits useful for the diagnosis, prognosis, and treatment of CNS lymphoma.... Agent: Don D. Cha

20070264642 - Direct multiplex characterization of genomic dna: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.... Agent: Ropes & Gray LLP Patent Docketing 39/41

20070264648 - Dna oligomer, genetic marker and dna oligomer set for prediction of onset of side-effect from radiation therapy, and method for predicting onset of side-effect: There are provided a DNA oligomer, a genetic marker, and a DNA oligomer set (PCR primer set) and a DNA oligomer (extension primer) for predicting a possibility of onset of a side-effect from radiation therapy for cancer by determining whether a specific base in a DNA sequence is a risk... Agent: Squire, Sanders & Dempsey L.L.P.

20070264660 - Dna replication factors: A DNA polymerase reaction system which provides high DNA polymerase activity even at a high temperature and at a high salt concentration. A DNA polymerase reaction system that is constructed from a DNA polymerase, a clamp, and a clamp loader without intein sequence, the DNA polymerase being from Pyrococcus horikoshii,... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070264633 - Dutp based compositions for reducing primer-aggregate formations during nucleic acid amplification: Methods and compositions are provided for enhanced specificity and sensitivity of amplification reaction mixtures. Compositions in accordance with the present invention provide for reduced formation of primer-aggregates during amplification reactions. Reaction mixes include dNTPs, where a portion of the dNTPs has been replaced with an unconventional nucleotide, e.g., dUTP. Unconventional... Agent: Dorsey & Whitney LLP

20070264646 - Hbv particles containing hbv-rna: Hepatitis B virus (HBV) particles that contain HBV-RNA but do not contain HBV-DNA in a body fluid sample; A method of measuring the particles according to claim 1 by measuring HBV-RNA; A method of judging the therapeutic effect of the treatment of HBV infections by a drug having an effect... Agent: Foley And Lardner LLP Suite 500

20070264666 - High density sequence detection methods: A method for performing PCR on a liquid sample comprising a plurality of polynucleotide targets, wherein each polynucleotide target is present at very low concentration within the sample. The method comprises applying PCR reactants to the surface of a substrate to produce a plurality of reaction spots on the surface... Agent: Harness, Dickey & Pierce, P.L.C

20070264639 - Identification of echinacea and its imposters using genetic variations: This invention provides methods, compounds, and kits for identifying Echinacea species and for distinguishing between Echinacea and imposter species based upon molecular variations. In particular, amplification primers are provided that amplify specific regions of nucleic acid sequences to generate unique amplification profiles in the different plant species. A plant may... Agent: Polsinelli Shalton Welte Suelthaus PC 100 S. Fourth Street

20070264638 - Identification of ginseng and its imposters using genetic variations: This invention provides methods, compounds, and kits for identifying ginseng (Panax) species and for distinguishing between ginseng and imposter species based upon molecular variations. In particular, amplification primers are provided that amplify polymorphic regions of nucleic acid sequences to generate distinct amplification profiles in the different plant species. A plant... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20070264645 - Il-1 gene cluster and associated inflammatory polymorphisms and haplotypes: The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris,

20070264630 - Method for detecting dna point mutations (single nucleotide polymorphism (snp) analysis) and associated arrangement: The single nucleotide polymorphism analysis involves the utilization of a DNA hybridization as well as the use of a DNA chip. A liquid DNA sample to be analyzed is guided over a DNA chip in a defined time course. After successful hybridization, the temperature is modified in a defined manner... Agent: Harness, Dickey & Pierce, P.L.C

20070264652 - Method for detection of a sequence: The present invention provides a novel method for detection of a sequence in a given sample, comprising the steps of isolating the target sequence from the given sample, providing a first and second probe comprising an oligo-nucleotide sequences complementary to respective ends of the target sequences and conjugated to a... Agent: Oliff & Berridge, PLC

20070264644 - Method for distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma: The present invention is a method distinguishing between head and neck squamous cell carcinoma and lung squamous cell carcinoma. In particular, a 10-gene classifier has been identified which can be used to distinguish between primary squamous cell carcinoma of the lung and metastatic head and neck squamous cell carcinoma. These... Agent: Licata & Tyrrell P.C.

20070264632 - Method for identification of enzymes: The present invention provides a method of identifying an enzyme, the method generally involving contacting a sample containing an enzyme with a selected enzyme substrate, where the contacting provides for covalent binding of the substrate to an amino acid of the enzyme to form a covalently modified enzyme; and determining... Agent: Bozicevic, Field & Francis LLP

20070264661 - Method for rapid identification of molecules with functional activity towards biomolecular targets: The present invention provides mass spectrometry-based methods for high throughput identification of molecules with functional activities such as nuclease, protease, reductase, kinase, phosphatase, or transferase activities towards biomolecular targets. These methods are useful for screening biological samples such as extracts, broths, lysates and natural product mixtures and provide valuable insights... Agent: Pepper Hamilton LLP

20070264649 - Method for the combined isolation of magnet-beads from a liquid sample and subsequent thermocyclisation for the polymerase chain reaction (pcr) and associated arrangement: Embodiments generally relate to a PCR wherein a magnetic field is focused in a localised area and also to the possibility of a cyclic transfer of heat. According to at least one embodiment of the invention, a magnetic field gradient is constructed along the direction of flow and the transfer... Agent: Harness, Dickey & Pierce, P.L.C

20070264653 - Method of identifying a biological sample for methylation analysis: Aspects of the present invention relate to compositions and methods of identifying at least one biological sample in the field of methylation analysis. In particular aspects at least one biological sample is provided, at least one identifier is applied for each sample, the applied identifier(s) are detected or quantified, and... Agent: Kriegsman & Kriegsman

20070264631 - Method of judging risk for onset of drug-induced granulocytopenia: Means for determining the presence of the risk of drug-induced granulocytopenia in a human is provided. A method for assessing the risk of drug-induced granulocytopenia, including detecting a polymorphism of the human insulin receptor substrate-2 gene of a subject, and determining the presence of the risk of drug-induced granulocytopenia of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070264663 - Methods and reagents for detecting susceptibility to graft versus host disease or transplant related mortality: The present invention provides methods for determining the likelihood and/or severity of GvHD and the likelihood of the occurrence of transplant related mortality.... Agent: Philip S. Johnson Johnson & Johnson

20070264654 - Methods for identifying polypeptide targets and uses thereof for treating immunological diseases: The present invention provides methods for identifying viral virulence factors and for identifying cellular polypeptides to which the viral polypeptides bind. The cellular polypeptide is useful as a therapeutic target or as a therapeutic agent for treating diseases and disorders, including immunological diseases or disorders.... Agent: Seed Intellectual Property Law Group PLLC

20070264651 - Methods, compositions, and kits for the detection and monitoring of kidney cancer: Methods and compositions for the diagnosis and monitoring of kidney cancer are disclosed.... Agent: Seed Intellectual Property Law Group PLLC

20070264641 - Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection: The invention provides methods and processes for the identification of polymorphisms at one or more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site.... Agent: Eric P. Mirabez

20070264634 - Nano-chem-fet based biosensors: Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising functionalized and/or non-functionalized nanowires are provided. Nanosensors are, used for detection in cellular fragmentation, multiple concentration analysis, glucose detection, and intracellular analysis.... Agent: Nanosys Inc.

20070264665 - Nonseparation assay methods: Assay methods are disclosed involving specific binding reactions which are simplified compared to known methods. A compound capable of producing chemiluminescence is immobilized on a solid support as is a member of a specific binding pair for capturing an analyte from a sample. An activator compound that activates the chemiluminescent... Agent: Nexgen Diagnostics, LLC

20070264662 - Polynucleotides encoding human slap-2 variants, hslap-2v3 and hslap-2v4: The invention relates to the identification and cloning of a two novel full-length human SLAP-2 variants and their encoded polypeptides, hSLAP-2v3 and hSLAP-2v4. hSLAP-2v3 and hSLAP-2v4 are members of the SLAP family of adapter proteins and are involved in the negative regulation of intracellular T-cell signal transduction. The invention further... Agent: Louis J. Wille Bristol-myers Squibb Company

20070264635 - Probe, probe set and information acquisition method using the same: The present invention provides a combination of genes useful for information which can be used for the prediction of postoperative recurrence of gastric cancer and the acquisition of the information, a probe detecting these genes and a primer set for PCR, a method for detecting these genes using the primer... Agent: Fitzpatrick Cella Harper & Scinto

20070264647 - Stabilization of h2o2 under alkaline conditions for use in luminescence, fluorescence and colorimetric assays fro enhanced detection of peroxidase type assays: The invention relates to stannous halide stabilized and/or enhanced alkaline solutions to be used in combination with calorimetric, luminescent and fluorescent assays. The buffered solutions stabilize hydrogen peroxide at a pH greater than 7.0 and preferably greater than 9.0. By stabilizing and/or enhancing hydrogen peroxide in the buffer system, the... Agent: Drinker Biddle & Reath (dc)

20070264650 - Universal fieldable assay with unassisted visual detection: A universal detection system based on allosteric aptamers, signal amplification cascade, and eye-detectable phrase transition. A broadly applicable homogeneous detection system is provided. It utilizes components of the blood coagulation cascade in the presence of polystyrene microspheres (MS) as a signal amplifier. Russell's viper venom factor X activator (RVV-X) triggers... Agent: Hogan & Hartson L.L.P.

20070264669 - Compositions and methods for the enhancement of soluble amyloid beta oligomer (addl) uptake and clearance: The present invention relates to methods for enhancing the cellular uptake and clearance of soluble oligomeric Aβ peptide assemblies from the environment surrounding both neuronal and non-neuronal cells. Oligomeric Aβ peptide assembly uptake and clearance is achieved via an agent that enhances insulin receptor signaling. Such ADDL uptake enhancers represent... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20070264667 - Method and system for assaying transferase activity: Embodiments of the present invention are directed to sensitive, specific, and commercially feasible assays for transferase activity. Various embodiments of the present invention include artificial, multifunctional substrates specific for particular transferases that are chemically altered by the transferases to produce easily detectable, modified, multifunctional substrates. In one class of embodiments,... Agent: Olympic Patent Works PLLC

20070264668 - O-acetyltranferases: A post-translational modification of a predetermined protein expressed by a cell is detected by specifically detecting an O-acetylation of a serine, threonine or tyrosine residue of the protein as an indication of the posttranslational modification. The detection may employ antibodies that specifically bind an O-acetylated protein expressed by the cell,... Agent: Richard Aron Osman

20070264673 - Assessing rheumatoid arthritis by measuring anti-ccp and interleukin 6: The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of anti-CCP and... Agent: Roche Diagnostics Operations Inc.

20070264674 - Cytochrome p450 induction assay: A method for identifying compounds that can induce expression of cytochrome P450, in particular, expression of the CYP3A4 isoform, is described. The method provides a reporter gene operably linked to a composite promoter comprising in tandem one or more cis-acting elements, which are bound by activated pregnane X receptor (PXR),... Agent: Merck And Co., Inc

20070264675 - Microfluidic device for cell separation and uses thereof: The invention features methods for separating cells from a sample (e.g., separating fetal red blood cells from maternal blood). The method begins with the introduction of a sample including cells into one or more microfluidic channels. In one embodiment, the device includes at least two processing steps. For example, a... Agent: Clark & Elbing LLP

20070264671 - Diagnosis and prognosis of dipeptidyl peptidase-associated disease states: A method is provided for the diagnosis or prognosis of a disease state, involving the measurement of a parameter of discriminated dipeptidyl dipeptidases from a patient sample, and the correlation of the parameter with a disease.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20070264670 - Method for screening and selecting enzymes: The present invention relates to a method for identifying an enzyme of interest comprising screening a set of candidate enzymes on an application matrix, preferably on at least a medium throughput level, and selecting enzymes for their ability to produce a functionality change in the application matrix. In the application... Agent: Nixon & Vanderhye, PC

20070264672 - Development of a novel assay for mgmt (methyl guanine methyl transferase): The present invention provides improved methods for assessing the level of MGMT activity in a variety of biological preparations. MGMT, a DNA repair enzyme, can reduce the chemotherapeutic efficacy of alkylating agents by repairing the damage that alkylating agents do to tumor cell DNA. The methods of the present invention... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070264676 - Aminated materials for assays: Protein binding onto a polymeric surface is enhanced by treating the surface with an amine-bearing polymer like poly(ethylene imine). When used in ELISA, the treated surface improves the performance of the assay.... Agent: Fay Sharpe LLP

20070264678 - Kinase and ubiquination assays: Compositions, including antibodies, polypeptides, and organic molecules, kits, and methods for probing molecular interactions (e.g., deubiquination, ubiquination and kinase activity), e.g., using resonance energy transfer (RET) are provided.... Agent: Invitrogen Corporation C/o Intellevate

20070264679 - Method for analyzing the activity of lipoxygenase using a water-soluble substrate: The present invention discloses methods for analyzing the activity of lipoxygenase by using polyunsaturated lysophosphatidylcholine as a water-soluble substrate. In these methods, lipoxygenase activity can be analyzed without using detergents in reaction solution.... Agent: Edwards Angell Palmer & Dodge LLP

20070264682 - Cell culture model and applications thereof: The present invention relates to a multicellular model comprising at least, as cell type: keratinocytes, melanocytes, and nerve cells, in which the keratinocytes and the melanocytes form a first cell layer, said nerve cells form a second cell layer devoid of physical contact with the first cell layer, said first... Agent: Oliff & Berridge, PLC

20070264681 - Cell cycle phase markers: The present invention relates to polypeptide and nucleic acids constructs which are useful for determining the cell cycle status of a mammalian cell. Host cells transfected with these nucleic acid constructs can be used to determine the effects that test agents have upon the mammalian cell cycle.... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070264680 - Method and test-kit for the detection and quantification of organisms: The present invention provides methods and test-kits for rapidly detecting and/or quantifying a group of organism, cultivable or not cultivable, sharing the same enzymatic activity. In particular, the methods and kits can be used for example in the field of cosmetics, where the activities of (microbial) enzymes, which are responsible... Agent: Hunton & Williams LLP Intellectual Property Department

20070264684 - Cytokine protein family: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral... Agent: Zymogenetics, Inc. Intellectual Property Department

20070264689 - Human tumor necrosis factor receptor: Tumor necrosis factors and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human tumor necrosis factor receptor designated as “Ztnfr12.”... Agent: Zymogenetics, Inc. Intellectual Property Department

20070264690 - Nucleic acids encoding lettuce big-vein viral proteins and utilization thereof: The coat protein of lettuce big-vein virus (LBVV) was purified from highly purified LBVV, and its partial amino acid sequences were determined. An RNA encoding the coat protein of LBVV was cloned by polymerase chain reaction using primers designed based on the determined amino acid sequences information, and its primary... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070264685 - Polynucleotides encoding cytokine receptor: Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention... Agent: Zymogenetics, Inc. Intellectual Property Department

20070264687 - Recombinant triplex scaffold-based polypeptides: Disclose is a protein complex that includes triple-helix-coil forming fusion polypeptide chains, each having a scaffold domain and a heterologous domain. Also disclosed are related isolated fusion polypeptide, nucleic acids, vectors, host cells, and preparation methods.... Agent: Fish & Richardson PC

20070264686 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Genentech, Inc.

20070264688 - Synthetic genomes: Methods are provided for constructing a synthetic genome, comprising generating and assembling nucleic acid cassettes comprising portions of the genome, wherein at least one of the nucleic acid cassettes is constructed from nucleic acid components that have been chemically synthesized, or from copies of the chemically synthesized nucleic acid components.... Agent: Carr & Ferrell LLP

20070264692 - Ligand-dependent protein splicing: Ligand-dependent inteins allow for modulation of a protein's activity in vivo. Upon binding of the ligand to the ligand-dependent intein inserted into the protein of interest, the hybrid protein undergoes protein splicing removing the intein. The activity of the spliced protein is then restored. A 4-hydroxytamoxifen-dependent intein based on the... Agent: Choate, Hall & Stewart/harvard University

20070264693 - Hyphal growth in fungi: The present invention provides a method for producing desired proteins or chemicals in fungal host cells, which comprise modulating the nucleic acid encoding proteins associated with hyphal growth. The amino acid and nucleic acid sequences of hbrA and hbrB are provided.... Agent: Genencor International, Inc.

20070264694 - Use of non-standard bases and proximity effects for gene assembly and conversion of non-standard bases to standard bases during dna synthesis: The present methods relate to generating nucleic acid molecules using non-natural nucleotides. In some methods, the nucleic acid molecules may be generated by hybridizing a plurality of oligonucleotides comprising one or more non-natural nucleotides and using a polymerase and/or a coupling agent to link the hybridized oligonucleotides. The methods also... Agent: Foley & Lardner LLP

20070264695 - Method for producing a purified lipase: The present invention provides a method for producing a purified lipase which comprises steps of: (a) bringing a long chain fatty acid triglyceride and a medium-chain triglyceride into contact with a lipase to purify the lipase; and (b) collecting the purified lipase. According to this production method, the purified lipase... Agent: Buchanan, Ingersoll & Rooney PC

20070264696 - Method for producing biodegradable polyester: The present invention relates to a method to produce biodegradable polyester, which comprises the following steps: (a) mixing a carbon source, a nitrogen source and water into a reactive material to perform pretreatment; (b) providing a halophilic bacterium, a starting broth and culture with the reactive material; (c) feeding the... Agent: Bacon & Thomas, PLLC

20070264697 - Method of biomass processing: A novel method of biomass processing, in which while carrying out efficient fermentation of biomass, energy can be recovered without the use of plants and in which after the biomass processing the concentration of organic matter in waste liquid can be reduced. There is provided a method of biomass processing,... Agent: Alston & Bird LLP

20070264698 - Information rich libraries: Methods of creating libraries of biological polymers are provided. The construction of a library employs a probability matrix for a reference sequence, and a constraint vector for which is applied to the probability matrix to produce a substitution scheme. The substitution scheme is then used to generate a library comprising... Agent: Genencor International, Inc. Attention: Legal Department

20070264699 - Method for cyrstallizing human gsk3 and novel crystal structure thereof: The invention provides the three-dimensional structure of a construct of human glycogen synthase kinase 3 (GSK3); crystals of a construct of human glycogen synthase kinase 3-β (GSK3-β) containing the protein's catalytic kinase domain; a method for crystallizing the protein construct to provide a GSK3 crystal sufficient for structure determination; and... Agent: Chiron Corporation Intellectual Property - R440

20070264700 - Fungal alpha-amylase variants: The inventors have developed a method of altering the amino acid sequence of a fungal alpha-amylase to obtain variants, and they have used the method to construct such variants. The variants may be useful for anti-staling in baked products. Accordingly, the invention provides a method of constructing fungal alpha-amylase variants... Agent: Novozymes North America, Inc.

20070264701 - Waste water microbial growth promoter composition of matter and method of use: The invention comprises a composition of matter, method of preparing same, and a method of use. The composition of matter or formulation increases biological activity. The product is both environmentally and physically safe. The formulation in the inventive composition increase the respiration and reproductive rates of most bacteria. Its method... Agent: Robert J. Van Der Wall Gables One Tower

20070264702 - Method of regulating heterologous protein expression controlled by salicylic deratives in micro-organisms associated with higher organisms: The invention relates to a method which can be used to control the expression of heterologous proteins in micro-organisms using an expression system controlled by salicylate or derivatives. The genetic system can be used in attenuated pathogenic bacteria that can be induced once hosted by the eukaryotic cell by concentrations... Agent: Arent Fox LLP

20070264704 - Bio-filter with low density media and toroidal media stirring configuration: A bio-reactor having a downflow self-cleaning configuration includes a liquid deflecting means generally concentric with a cylindrical tank. The liquid deflecting means is located just below the surface of liquid in the tank and is configured to direct liquid radially outwardly towards an inner surface of the tank. The liquid... Agent: Simpson & Simpson, PLLC

20070264703 - Microorganism and method for leaching mineral sulphides: The present invention relates to a method of bioleaching mineral sulphides at high temperatures and extremely low pH. In particular, the invention relates to a method which employs a microorganism of the genus Acidianus which is a thermophile and an extreme acidophile.... Agent: Mcdermott Will & Emery LLP

20070264705 - Apparatus and method for handling cells, embryos or oocytes: Apparatus for handling cellular entities comprises a first substrate having an array of first wells open to a first major surface of the first substrate, said first wells being adapted to hold a cellular entity, the apparatus further comprises fluidic channels open to each well. The wells are tapered to... Agent: Heller Ehrman LLP

20070264707 - Automated analyzer using light diffraction: The present invention provides an automated analyzer system for performing chemical, biochemical or biological assays using changes/no changes in diffraction of light by the presence/absence of analytes which may or may not be present in a sample binding to their analyte specific receptors laid out in a preselected pattern in... Agent: Ralph A. Dowell Of Dowell & Dowell P.C.

20070264706 - Nanoporous membrane immunosensor: A sensor for a selected analyte in a test sample has (a) a semipermeable membrane with pores for retaining the analyte, where the membrane has been chemically modified by attachment of membrane modifiers; (b) immunoassay labels which have label binding ligands where these label binding ligands will have a binding... Agent: Naval Research Laboratory Associate Counsel (patents)

20070264708 - Apparatus and method for growing biological organisms for fuel and other purposes: A bioreactor apparatus in which a container has sidewalls, a floor and a ceiling defining a chamber that contains a slurry of water, nutrients and photosynthetic microorganisms. A plurality of optical fibers, each of which has a first end disposed outside the chamber and a second end in the mixture.... Agent: Kremblas, Foster, Phillips & Pollick

20070264709 - Lineage specific cells and progenitor cells: A method for generating a culture that is purified or enriched in respect of cells of a selected lineage is described in which a selectable marker, which is differentially expressed in cells of the selected lineage compared with its expression in other cells, is introduced into a multipotential cell and... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070264710 - Process for purifying human thrombopoietin with high content of sialic acid: Disclosed is a process for producing a human thrombopoietin (hTPO)-containing culture fluid, comprising the step of culturing a eukaryotic cell expressing hTPO in a serum-free medium that contains a negligible amount of serum. In addition, the present invention discloses a process for purifying hTPO from a hTPO-containing biological fluid, comprising... Agent: Medlen & Carroll, LLP

20070264711 - Human pellino polypeptides: There are disclosed novel polypeptides referred to as Pellino polypeptides, as well as fragments thereof, including immunogenic peptides. DNAs encoding such polypeptides as well as methods of using such DNAs and polypeptides are also disclosed.... Agent: Immunex Corporation Law Department

20070264712 - Expansion and differentiation of neural stem cells under low oxygen conditions: The present invention encompasses methods and compositions for enhancing the growth of neural stem cells (NSCs). The invention relates to the benefits of culturing NSCs under lowered oxygen conditions as compared to environmental oxygen conditions traditionally employed in cell culture techniques.... Agent: Seed Intellectual Property Law Group PLLC

20070264713 - Scalable process for cultivating undifferentiated stem cells in suspension: The invention relates to a process for cultivating undifferentiated stem cells in suspension and in particular to a method for cultivating stem cells on microcarriers in vessels. The method enables stem cells to be cultivated in a scalable process for the first time, without losing their pluripotentiality. Different types of... Agent: Barnes & Thornburg LLP

20070264714 - Growth differentiation factor-9 regulatory sequences and uses therefor: Isolated GDF-9 regulatory sequences are disclosed, as well as methods of using the sequences to modulate tissue-specific expression of genes. The GDF-9 regulatory sequences include, for example, enhancer and promoter elements that naturally drive transcription of GDF-9 in specific tissues. The GDF-9 regulatory sequences can be derived from the untranscribed... Agent: Lahive & Cockfield, LLP

20070264715 - Proteins involved in signal transduction: The method relates to a method of modulating quorum sensing in bacteria. Quorum sensing is inhibited using peptide hydrolases. This inhibition is used to prevent biofilm formation or to break down established biofilms and may also be used to downregulate the production of virulence determinants by pathogenic bacteria. The invention... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20070264716 - Methods and materials for the transformation of the yeast pichia ciferrii: The present invention discloses a transformation system useful for the genetic engineering of the industrial yeast Pichia ciferrii. It describes the isolation of auxotrophic mutants of this yeast and nucleotide sequences able to complement the auxotrophic requirements of these strains. The transformation system is based on mutant Pichia ciferrii cells... Agent: Oliff & Berridge, PLC

20070259330 - Separation of cells: The present invention relates to the isolation of human stem cells for use e.g. in cell therapy. More specifically, the invention is a method of separating mononuclear cells from human blood, which method comprises providing a human blood sample together with density gradient media (DGM) in a container; spinning the... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070259344 - Compound probes and methods of increasing the effective probe densities of arrays: Methods and articles for analyzing nucleotide sequences of nucleic acid molecules, e.g., using multiple probes per spot of an array, are described. In some embodiments, the methods and articles can reduce the numbers of arrays necessary to probe regions of interest in a biological sample, and/or increase the resolution at... Agent: Agilent Technologies Inc.

20070259369 - Detecting t(1;19): This document provides methods and materials related to detecting t(1;19) as well as methods and materials for identifying or assessing cancer within a mammal (e.g., a human). For example, methods for assessing the aggressiveness of a low-grade glioma in a human are provided.... Agent: Fish & Richardson P.C.

20070259368 - Gastric cancer biomarker discovery: The present application discloses an epigenetic marker for gastric cancer.... Agent: Jhk Law

20070259367 - Method to diagnose and increase fertility of mammalian semen using dnase as a diagnostic marker and therapeutic agent: A method and a corresponding composition of matter for diagnosing or increasing the fertility of semen is described. The method involves measuring DNase activity in a semen sample, wherein greater DNase activity in the semen sample indicates increased fertility of the semen sample. Also described is a corresponding composition for... Agent: Intellectual Property Department Dewitt Ross & Stevens S.c.

20070259347 - Methods of increasing the effective probe densities of arrays: Methods and articles for analyzing nucleotide sequences of nucleic acid molecules, e.g., using multiple probes per spot of an array, are described. In some embodiments, the methods and articles can reduce the numbers of arrays necessary to probe regions of interest in a biological sample, and/or increase the resolution at... Agent: Agilent Technologies Inc.

20070259345 - Target determination using compound probes: The present invention generally relates to systems and methods for identifying and/or quantifying targets such as nucleic acid targets using compound probes (e.g., oligonucleotide probes), which can comprise first and second sequences able to hybridize to one or more nucleic acids or portions thereof. In one aspect, a nucleic acid... Agent: Agilent Technologies Inc.

20070259398 - Microwave assisted deglycosylation of proteins for molecular weight determination by mass spectrometry: Methods are presented for microwave assisted, enzymatic deglycosylation of proteins. The rate at which deglycosylation is achieved and without protein degradation facilitates rapid and accurate molecular weight determination by mass spectrometry.... Agent: Genentech, Inc.

20070259328 - Artificial tissue construct and method for producing the same: An object of the present invention is to provide an artificial tissue construct that has means for transporting nutrients, oxygen, waste products, or the like and is viable in vivo. The present invention relates to a tissue construct formed in vitro, which comprises a vascular layer, a basal membrane layer,... Agent: Sughrue Mion, PLLC

20070259327 - Cryopreservation medium and cryopreservation method for tissues and cells: A cryopreservation medium and a cryopreservation method which make it possible to cryopreserve tissues and cells with high viability are provided. A cryopreservation medium contains polyphenol at a concentration of from 30 to 120 ppm. In an embodiment, a cryopreservation method for tissues and cells comprises: incubating tissues or cells... Agent: Jordan And Hamburg LLP

20070259329 - Anergy-inducing cellular composition: The invention is directed to an anergy-inducing cellular composition comprising: cells having antigenic determinants on the cell surface and an anergy-inducing compound [e.g., (−)-epigallocatechin-3-o-gallate (EGCG)] attached by its chemical affinity to the antigenic determinants. In one embodiment, the anergy-inducing compound blocks co-stimulatory molecules among the antigenic determinants of the cells,... Agent: Jordan And Hamburg LLP

20070259332 - Compositions and methods for simultaneous detection of volatile sulfur compounds and polyamines: Disclosed are compositions and methods useful for the rapid and facile simultaneous detection of malodorous bacterial metabolites in samples of expired breath and other fluids. The invention enables estimation, by simple visual inspection and comparison against standards, of the concentration of polyamines and volatile sulfur compounds in the micromolar to... Agent: Viksnins Harris & Padys Pllp

20070259331 - Method and device for probing changes in a membrane by applying an in-plane electric field: The present invention is directed to disposing a membrane, for example, a biological cell membrane including amphiphilic lipids and proteins, or a liquid crystal membrane, between two electrical conductive walls having a height that is at least as great as the thickness of the membrane and, in particular, approximates the... Agent: Pearne & Gordon LLP

20070259333 - Novel zwitterionic dyes for labeling in proteomic and other biological analyses: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070259334 - Preservation of bioactive materials by spray drying: This invention provides methods and compositions to preserve bioactive materials in a matrix of powder particles. Methods provide high-pressure gas spraying and/or near supercritical spraying of formulations followed by drying in a stream of conditioned gas to form stable powder particles containing bioactive materials.... Agent: Quine Intellectual Property Law Group, P.C.

20070259335 - Method for predicting de novo biomacromolecule crystallization conditions and for crystallization of the same: A method de novo is provided for predicting crystallization conditions and for crystallizing biomacromolecules, in particular proteins. The method provides a simple, quick and precise approach in determining the biomacromolecule solubility in different solutions, as well as the boundary between crystallization and aggregation. Because the method relies only on monitoring... Agent: Fish & Richardson, PC

20070259339 - Methods and reagents for genotyping hcv: The present invention is directed to methods and reagents for determining the genotype of a hepatitis C virus (HCV) species present in a test sample. The invention more particularly relates to mixtures of degenerate amplification and sequencing primers, and methods of using such primers, that are complementary to a plurality... Agent: Brinks Hofer Gilson & Lione Utah Office

20070259337 - Methods and systems for designing primers and probes: The invention provides methods for designing polynucleotide primers and probes that are optimized for hybridizing to a plurality of target nucleic acid variants by employing scoring and/or ranking steps that provide a positive or negative preference or “weight” to certain nucleotides in a candidate nucleic acid sequence. The particular scoring... Agent: Docketing Specialist Sullivan & Worcester LLP

20070259336 - Methods for the detection of analytes in a sample: A method for detecting the presence or concentration of an analyte in a sample, wherein: a) the sample is contacted with an immobilized first binding reagent which is capable of binding the analyte if present in the sample; b) the sample is contacted with a second binding reagent which comprises... Agent: Ropes & Gray LLP Patent Docketing 39/41

20070259338 - Particle based homogeneous assays using capillary electrophoresis with laser-induced fluorescence detection: The invention provides highly sensitive and rapid homogeneous assays which employ particle-enhanced assay formats in concert with capillary electrophoresis and laser-induced fluorescence (LIF) detection to determine the concentration of an analyte of interest in a sample. Such a determination is made by measuring fluorescent signal(s) (i.e., an electropherogram) produced upon... Agent: Hogan & Hartson L.L.P.

20070259346 - Analysis of arrays: Techniques and equipment are provided, including computer-related software and hardware, for analyzing biological events on multiple-spot arrays for chemical, biological, or biochemical analysis. In one arrangement, techniques and equipment are provided for analyzing nucleotide sequences of nucleic acid molecules, e.g., using multiple probes per spot of an array. Arrays can... Agent: Agilent Technologies Inc.

20070259349 - Bladder cancer-related nucleic acids: Described herein are novel polynucleotides associated with bladder cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of bladder cancer. Also described herein are methods that can be used to identify modulators of the... Agent: Rosetta-genomics C/o Psws

20070259356 - Concatameric ligation products: compositions, methods and kits for same: The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070259364 - Detection of methylated cpg rich sequences diagnostic for malignant cells: The present invention provides methods for determining the methylation status of CpG-containing dinucleotides on a genome-wide scale using infrequent cleaving, methylation sensitive restriction endonucleases and two-dimensional gel electrophoretic display of the resulting DNA fragments. Such methods can be used to diagnose cancer, classify tumors and provide prognoses for cancer patients.... Agent: Calfee Halter & Griswold, LLP

20070259370 - Detection of mutational frequency and related methods: Methods are provided herein for measuring the mutational frequency of a DNA molecule in cells, for example stem cells or hematopoietic cells such as CD34+ cells or granulocytes. The method includes sequencing corresponding regions of mtDNA from a set of hematopoietic cells, or a set of clonal populations of hematopoietic... Agent: Klarquist Sparkman, LLP

20070259366 - Direct printing of patterned hydrophobic wells: The present invention comprises a diagnostic platform. The platform has a substrate having plurality of hydrophobic wells formed thereon. The hydrophobic wells are directly printed onto the substrate in a test pattern and are adapted to contain a biological sample for conducting a diagnostic assay to identify analytes within the... Agent: Bose Mckinney & Evans LLP James Coles

20070259351 - Evaluating genetic disorders: The present invention relates to genetic analysis and evaluation utilizing copy-number variants or polymorphisms. The methods utilize array comparative genomic hybridization and PCR assays to identify the significance of copy number variations in a subject or subject group.... Agent: Wilson Sonsini Goodrich & Rosati

20070259373 - Identification and modulation of a g-protein coupled receptor (gpcr), rai3, associated with chronic obstructive pulmonary disease (copd) and nf-kb and e-selectin regulation: The present invention describes a G-protein coupled receptor (GPCR) family member newly identified as being modified, e.g., phosphorylated, and associated with tyrosine phosphorylated activation complexes, following exposure of cells to smoke from tobacco burning substances, namely, cigarette smoke. This GPCR protein is RAI-3, which was first found to be phosphorylated... Agent: Louis J. Wille Bristol-myers Squibb Company

20070259374 - In vitro sorting method: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070259358 - Integrase cofactor: In a study of HIV-1 integrase (IN) complexes derived from nuclei of human cells stably expressing the viral protein from a synthetic gene it was demonstrated that in the nuclear extracts IN exists as part of a large distinct complex with apparent Stokes radius of 61 Å, which dissociates upon... Agent: Clark & Elbing LLP

20070259350 - Liver cancer-related nucleic acids: Described herein are novel polynucleotides associated with liver cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of liver cancer. Also described herein are methods that can be used to identify modulators of the... Agent: Rosetta-genomics C/o Psws

20070259342 - Lymphoma associated molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated BBAP nucleic acid molecules, which encode proteins that interact with or bind to BAL molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BBAP nucleic acid molecules, host cells into which... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070259348 - Lyophilized pellets: Lyophilized pellets, suitable for use in a microfluidic device, and a method for preparing the same are described. The lyophilized pellets contain various biological reagents, or microparticles, and a cryoprotectant. The lyophilized pellets have a high degree of sphericity and are in the size range 0.5 to 35 μL. The... Agent: Fish & Richardson P.C.

20070259360 - Marker for judging lymph node metastasis of breast cancer, a primer, and a method for judging lymph node metastasis of breast cancer using the marker: The object of the present invention is to provide a novel marker for a correct diagnosis of lymph node metastasis of breast cancer. This object is attained by a marker for judging lymph node metastasis of tumor cells derived from breast cancer, the marker including mRNA of the gene encoding... Agent: Sughrue Mion, PLLC

20070259372 - Melanoma differentiation associated gene - 5 and promoter and uses thereof: The invention provides for an isolated nucleic acid encoding Mda-5 (melanoma differentiation associated gene-5) and an isolated Mda-5 polypeptide. The invention further provides a vector comprising the nucleic acid encoding Mda-5, as well as a host cell comprising the vector. The invention provides an antibody which specifically binds to an... Agent: Baker Botts L.L.P.

20070259340 - Method and device for integrated nucleic acid integrity assessment and analysis: The present invention relates to methods for integrated ribonucleic acid integrity assessment and analysis comprising the steps of: (a) providing a support having immobilized thereon a set of detector probes and a set of at least two control probes, wherein (i) a first of said at least two control probes... Agent: Amster, Rothstein & Ebenstein LLP

20070259371 - Methods of enriching for and identifying polymorphisms: The invention encompasses methods for enriching for and identifying a polymorphism within a nucleic acid sample either by separating a subset of a nucleic acid sample or by selectively replicating a subset of a nucleic acid sample such that the polymorphism is contained within a nucleic acid population with reduced... Agent: Agilent Techologies Inc

20070259362 - Methods, apparatus, and computer programs for verifying the integrity of a probe: The present invention provides methods, apparatuses and computer programs for verifying the integrity of a probe by comparing the fluorescence value of a probe to a threshold value. The invention also provides for methods, apparatuses and computer programs for normalizing the fluorescence value of a probe and detecting a target... Agent: Townsend And Townsend And Crew, LLP

20070259361 - Methods, compositions, and kits for the detection and monitoring of bladder cancer: Methods and compositions for the diagnosis and monitoring of bladder cancer are disclosed.... Agent: Seed Intellectual Property Law Group PLLC

20070259365 - Multifunctional oligomer probe array and method of manufacturing the same: A multifunctional oligomer probe array capable of simultaneously performing different analyses such as gene expression profiling and genotyping includes a substrate, a first array region, a second array region, and a column spacer. The first array region has a plurality of first probe cell active regions, one or more oligomer... Agent: F. Chau & Associates, LLC

20070259359 - Nanoelectronic detection of biomolecules employing analyte amplification and reporters: Methods of detection of biomolecules are described, including methods of amplification of analyte target species and target reporters by analyte-triggered action of an enzyme such a nuclease, polymerase, and the like. Amplified target species (e.g., amplicons and reporters) are detectable by several embodiments of nanoelectronic sensors having aspects of the... Agent: O'melveny & Myers LLP

20070259357 - Nucleic acid analysis using sequence tokens: The present invention provides methods and compositions for tagging nucleic acid sequence fragments, e.g., a set of nucleic acid sequence fragments from a single genome, with one or more unique members of a collection of oligonucleotide tags, or sequence tokens, which, in turn, can be identified using a variety of... Agent: Bozicevic, Field & Francis LLP

20070259354 - Optimized trpm8 nucleic acid sequences and their use in cell based assays and test kits to identify trpm8 modulators: Modified human TRPM8 nucleic acid sequences which are efficiently expressed in human cells and cell-based assays and test kits containing same are provided. These assays identify TRPM8 modulators using cells that express a modified human TRPM8 nucleic acid sequence according to the invention, wherein said sequence has been modified relative... Agent: Hunton & Williams LLP Intellectual Property Department

20070259363 - Phylogenetic analysis of mass spectrometry or gene array data for the diagnosis of physiological conditions: A universal data-mining platform capable of analyzing mass spectrometry (MS) serum proteomic profiles and/or gene array data to produce biologically meaningful classification; i.e., group together biologically related specimens into clades. This platform utilizes the principles of phylogenetics, such as parsimony, to reveal susceptibility to cancer development (or other physiological or... Agent: Merek, Blackmon & Voorhees, LLC

20070259341 - Prion-like form of cpeb and related compositions and methods: The present invention provides methods for determining whether an agent facilitates the conversion of a cytoplasmic polyadenylation element binding (CPEB) protein from its non-prion form to its prion form. This invention also provides methods for determining the presence and amount of the prion form of CPEB protein in a cell.... Agent: Cooper & Dunham, LLP

20070259352 - Prostate cancer-related nucleic acids: Described herein are novel polynucleotides associated with prostate cancer. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of prostate cancer. Also described herein are methods that can be used to identify modulators of the... Agent: Rosetta-genomics C/o Psws

20070259353 - Rt-pcr profiling for the analysis of placental trophoblast cell lineages: A method of comprehensively identifying a specific placental cell lineage of a placental cell sample, applicable to all placental species, is provided. The method employs RT-PCR technology and comprises detecting expression markers unique for each of four trophoblast cell lineages using specifically designed inventive PCR primer pair panels. Diagnostic and... Agent: Dinsmore & Shohl LLP

20070259355 - Screening method for identifying pufa pks in samples: The invention relates to a method for the rapid and simple identification of PUFA PKS in microorganisms. Said method is characterized by the fact that DNA sections representing PKS that produce specifically for PUFA (polyunsaturated fatty acids) are reproduced in vitro. The PUFA PKS-specific amino acid sequence LGIDSIKRVEIL makes it... Agent: Hammer & Hanf, PC

20070259343 - Somatic transfer of modified genes to predict drug effects: The present invention relates to somatic cell gene transfer methods for mimicking one or more effects of a drug candidate compound. In one aspect, the methods mimic the effect of a drug candidate compound with potential to potentiate or suppress activity of a selected target molecule. In another aspect, the... Agent: Edwards Angell Palmer & Dodge LLP

20070259375 - Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators in non-small cell lung cancer: EGFR biomarkers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing a biological sample from the mammal to the EGFR modulator and (b) measuring in the biological sample the level... Agent: Louis J. Wille Bristol-myers Squibb Company

20070259377 - Diabetes-associated markers and methods of use thereof: Disclosed are methods of identifying subjects with Diabetes, pre-Diabetes, or a pre-diabetic condition, methods of identifying subjects at risk for developing Diabetes, pre-Diabetes, or a pre-diabetic condition, methods of differentially diagnosing diseases associated with Diabetes, pre-Diabetes, or a pre-diabetic condition from other diseases or within sub-classifications of Diabetes, methods of... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20070259376 - Homocysteine immunoassay: In immunoassays such as homocysteine immunoassays, it is known that the measured values can be dispersed due to the influence of inhibiting substances present in a biological sample on the immunoreaction. The present invention provides among other things a method whereby the influence of the immunoreaction inhibiting substances is easily... Agent: Robert Deberardine Abbott Laboratories

20070259378 - Method for identifying agonists or antagonists of the g-protein coupled receptor mas-like 1: The invention relates to a method for identifying a compound which stimulates or attenuates the activity of the G protein-coupled receptor mas-like 1.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20070259380 - Method for measuring hyaluronic acid using hyaluronic acid binding protein: An object of the present invention is to provide a method utilizing a carrier for measuring hyaluronic acid wherein deposition of carrier is less, a storage stability is good and an accuracy in measurement has same high degree as that performed by the conventional reagents, and a reagent kit for... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070259379 - Regulation of glucose and insulin levels by gnt-4 glycosyltransferase activity: The invention is based on the discovery that the gylcosylation enzyme GnT-4 increases glyocsylation and the stability of glucose transporter (Glut) family members, e.g., by increasing lectin binding. Modulators of GnT-4 activity can therefore be identified and used for the treatment of diabetes or pre-diabetes. In addition, inhibitors of GnT-4... Agent: Townsend And Townsend And Crew, LLP

20070259384 - Methods for determining the potency, specificity, and toxicity of hematopoietic prostaglandin d2 synthase: The present invention relates to a novel and useful method for assaying compounds and agents for their ability to decrease or inhibit the activity of hematopoietic prostaglandin D2 synthase (hPGDS). Specifically, the present invention relates to assays for measuring the potency, specificity and toxicity of hPGDS inhibitors.... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20070259383 - Novel genes involved in epidermal differentiation, and uses thereof: A high-throughput in situ hybridization system was applied to the mouse foot pad epidermis to identify novel genes involved in epidermal differentiation. As a result, epidermal expression patterns were detected for about 100 unique mRNAs. Of these, two novel secreted proteins, dermokine-α and -β, which are expressed in the suprabasal... Agent: Townsend And Townsend And Crew, LLP

20070259385 - Methods and arrays for detecting cells and cellular components in small defined volumes: Arrays of single cells and methods of producing an array of single cells are described. Arrays with defined volumes between 10 attoliters and 50 picoliters enable single cell capture, detection and quantitation.... Agent: Peter G. Carroll Medlen & Carroll, LLP

20070259386 - Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis of breast cancer: Novel markers for breast cancer that are both sensitive and accurate. These markers are overexpressed in breast cancer specifically, as opposed to normal breast tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis of breast... Agent: Staas & Halsey LLP

20070259387 - Monoclonal antibodies specific for anthrax spores and peptides derived from the antibodies thereof: The present invention provides monoclonal antibodies which are highly specific for Bacillus spores. Also provided are peptides derived from those monoclonal antibodies. Both the antibodies and peptides are highly specific and can discriminate between spores of potentially lethal organisms such as Bacillus anthracis and other harmless but closely related bacilli... Agent: Needle & Rosenberg, P.C.

20070259381 - Methods and arrays for target analyte detection and determination of reaction components that affect a reaction: Methods are described for detecting reaction components with affect a reaction. Biomolecules such as enzymes can be addressed at the single molecule level in order to discover function, detect binding partners or inhibitors, and/or measure rate constants.... Agent: Peter G. Carroll Medlen & Carroll, LLP

20070259382 - Rapid localized cell trapping on biodegradable polymers: The present invention provides methods and compositions for cell-based arrays. A biotin-avidin system for the attachment of cells onto a surface also employs biodegradable polymers onto which avidin is disposed in a predetermined pattern.... Agent: Fulbright & Jaworski L.L.P.

20070259388 - Assays, antibodies, and standards for detection of oxidized and mda-modified low density lipoproteins: Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the assays, and a storage-stable standard (which may be used as a calibrator and/or control) are disclosed. MDA-modified LDL and OxLDL are implicated in atherosclerosis... Agent: Stephen P. Gilbert, Esq. Bryan Cave LLP

20070259389 - Photoproteins with enhanced bioluminescence and assays using the same: The present invention relates to photoproteins with enhanced bioluminescence obtained by mutagenesis of clytin, to their use as intracellular calcium indicators and in cell-based assays.... Agent: Arent Fox LLP

20070259390 - High throughput sarcomeric assay: The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.... Agent: Townsend And Townsend And Crew, LLP

20070259391 - Assessment of the effects of topical administration of chemodenervating pharmaceuticals: The present invention provides methods for assessing the activity of topically administered chemodenervating agents. In some embodiments, methods for assessing the activity of topically administered chemodenervating agents involve determining the extent of inhibition of acetylcholine release near the site of administration. In some embodiments, methods for assessing activity of topically... Agent: Choate, Hall & Stewart LLP

20070259392 - Method and kit for positively detecting toxic material: A method of positively detecting toxic materials within a sample, the method including contacting sub-mitochondrial particles having competent mitochondrial enzymes formed from inner membranes of mitochondria, an electron donor which transmits electrons to an electron transfer system of the sub-mitochondrial particles and the sample, and forming reaction resultants, adjusting a... Agent: Cantor Colburn, LLP

20070259393 - Plating media for the presumptive identification of listeria sp, listeria monocytogenes and listeria ivanovii: Isolation plating medium of a first color for the identification of Listeria sp. and Listeria monocytogenes and Listeria ivanovii containing a first chromogenic substrate that responds to phosphatidylinositol-specific phospholipase C enzymes to release precipitate of a second color into the medium and a second chromogenic substrate that responds to beta-glucosidase... Agent: Marshall A. Burmeister

20070259395 - Stabilized powdered formaldehyde: According to an aspect of the invention, a polymerized form of formaldehyde is available in granular form containing a polymerized form of formaldehyde, such as paraformaldehyde, a buffer, such as sodium phosphate dibasic anhydrous, and a stabilizer, such as hydroxymethyl cellulose, or hydroxypropyl methyl cellulose. When added to an aqueous... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20070259394 - Substrate for cell culture, producing method thereof and screening method for cell culture conditions utilizing the same: A cell culture substrate having at least one area for culturing a cell on a substrate, characterized in that the culturing area comprises an area releasably holding a biologically active substance having a biological activity to the cell and an area for immobilizing a biologically active substance having a biological... Agent: Fitzpatrick Cella Harper & Scinto

20070259396 - Process for producing plant-origin antibacterial substance: A process for producing an antibacterial substance which comprises disintegrating at least a part of tissue of the plant with an enzyme capable of acting on protopectin to release and recover the antibacterial substance therefrom, while a pectin substance is removed; and antibacterial or bacteriostatic compositions containing the antibacterial substance... Agent: Birch Stewart Kolasch & Birch

20070259397 - Enzymes: The present invention relates to enzymes and processes. In particular, there is described a host cell transformed or transfected with a nucleic acid encoding a plant-derived CCD enzyme.... Agent: Steptoe & Johnson LLP

20070259401 - Activatable recombinant neurotoxins: Compositions comprising activatable recombinant neurotoxins and polypeptides derived therefrom. The invention also comprises nucleic acids encoding such polypeptides, and methods of making such polypeptides and nucleic acids.... Agent: Dean G. Stathakis Allergan, Inc. T2-7h

20070259400 - Antibodies: The use of an ScFv Ab (ScFv Ab) capable of recognising a disease associated molecule (DAM) in the manufacture of a medicament for the prevention and/or treatment of a disease condition associated with a DAM is described. The ScFv Ab has therapeutic, diagnostic and prognostic applications.... Agent: Townsend And Townsend And Crew, LLP

20070259399 - Novel liplytic enzyme elip: The present invention provides a novel nucleic acid sequence, designated ELIP, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at least one novel lipolytic enzyme, recombinant lipolytic enzyme proteins and methods for... Agent: Janet K Castaneda Genencor International Inc

20070259402 - Pc5 as a factor ix propeptide processing enzyme: Compositions and methods for preparing Factor IX, Factor IX-containing fusion proteins, and Factor IX-containing conjugates with processing of Factor IX propeptide by PC5, are provided. In one embodiment PC5 is used to process a precursor polypeptide for a Factor IX-Fc monomer-dimer hybrid.... Agent: Wolf Greenfield & Sacks, P.C.

20070259403 - Hla-e chimeric molecule: The invention presents HLA-E chimeric molecules for providing nonhuman mammal cell with resistance to cytotoxicity by human NK cell, base sequences for coding the chimeric molecules, and nonhuman mammal cell and nonhuman mammal animal transformed by the base sequences. The HLA-E chimeric molecule of the invention is a peptide reforming... Agent: Birch Stewart Kolasch & Birch

20070259404 - Method of producing heterologous proteases: The present invention provides improved methods of producing S2A (or S1E) proteases in Gram-positive expression host cells, the method comprising the steps of (a) cultivating in a fed-batch fermentation a Gram-positive cell comprising at least one polynucleotide encoding the heterologous S2A/S1E protease under conditions conducive for production of the protease,... Agent: Novozymes North America, Inc.

20070259405 - Optimized interferon-beta gene: A new nucleic acid molecule that is codon-optimized to express beta interferon in Escherichia coli with greater efficacy.... Agent: Lucas & Mercanti, LLP

20070259406 - Antimicrobial compounds: The present invention relates to new antimicrobial compounds, in particular proteins, having the amino acid sequence XAlaUValLeuLysOUIleLysValAlaLysLysTyrAlaLysGlyValA*LeuA*AlaGlyAlaAsnIleOGlyGlyLys wherein X is hydroxy propionyl (Hop), U is α,β-didehydroalanine (Dha), O is α,β-didehydrobutyrine (Dhb), A* is aminobutyrine (Abu), wherein lanthionine ring structures are formed between Ala12 and Ala16, between Abu20 and Ala23 and... Agent: Medlen & Carroll

20070259407 - Enzyme for an in vivo and in vitro utilisation of carbohydrates: The invention is directed to an isolated DNA molecule which includes a gene encoding an enzyme protein which has an NADH dependent L-xylulose reductase activity. The DNA sequence encoding the enzyme protein was identified. The invention is further directed to a microorganism transformed with said DNA molecule of the invention,... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070259408 - Method for producing l-amino acids using the gap promoter: The present invention is directed to bacteria which contain a lysCFBR that encodes a feedback resistant aspartokinase enzyme and whose expression is under the control of a gleceraldehyde-3-phosphate dehydrogenase (gap) promoter. The bacteria may be used in the fermentative production of L-amino acids, especially, L-lysine.... Agent: Law Office Of Michael A. Sanzo, LLC

20070259409 - Microbial production of aromatic acids: The invention relates to the enzymatic production of aromatic acids using renewable carbon sources, such as sugars. Provided is a method for the microbial production of aromatic acids from a fermentable carbon substrate using a host cell capable of producing said aromatic acid, for instance cinnamic acid, para-hydroxycinnamic acid and... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20070259410 - Fermentive production of four carbon alcohols: Methods for the fermentive production of four carbon alcohols are provided. Specifically, butanol, preferably 2-butanol is produced by the fermentive growth of a recombinant bacteria expressing a 2-butanol biosynthetic pathway. The recombinant microorganisms and methods of the invention can also be adapted to produce 2-butanone, an intermediate in the 2-butanol... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070259411 - Solvent tolerant microorganisms and methods of isolation: Enterococcus bacteria having enhanced tolerance to butanols have been isolated. The bacteria are useful for the fermentive production of butanol. New methods for the isolation of butanol tolerant Enterococcus are also provided.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070259412 - Process for the production of biofuel from plant materials: An integrated process for the production of ethanol from woody plant material is provided, the process comprising: contacting a continuous flow of the plant material with a counter-current continuous flow of an aqueous ethanol solution at elevated temperature and pressure to provide plant material depleted of lignin; removing ethanol from... Agent: Speckman Law Group PLLC

20070259413 - Method of decomposing polyhydroxyalkanoate resin: A novel microorganism that directly and biologically degrades a polyhydroxyalkanoate resin and plastic containing the resin and a method therefor are provided. A method for degrading the polyhydroxyalkanoate resin, which comprises degrading the resin using a thermophile belonging to the genus Streptomyces, is provided.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070259414 - Methods and compositions for protein expression and purification: Methods for enhancing expression levels and secretion of heterologous fusion proteins in a host cell are disclosed.... Agent: Dann, Dorfman, Herrell & Skillman

20070259415 - Polyacryamide beads containing encapsulated cells: Polyacrylamide beads containing encapsulated cells were prepared by a process comprising the steps of (i) providing an aqueous solution of a mixture of acrylic monomers, (ii) providing a suspension of cells in an aqueous solution of a persulfate (iii) providing an emulsion of an aqueous solution of a tertiary amine... Agent: Nixon & Vanderhye, PC

20070259416 - Gas treatment systems and methods: Systems and methods for biological and chemical gas treatment are disclosed. The systems may generally include a biological treatment zone and a chemical oxidation zone. An oxidizing agent subsystem may deliver an oxidizing agent, such as chlorine dioxide, to the chemical oxidation zone. The oxidizing agent subsystem may generate the... Agent: Lowrie, Lando & Anastasi, LLP U0105

20070259417 - Directed evolution of novel binding proteins: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore... Agent: Dyax Corp. C/o Wolf, Greenfield & Sacks, P.C.

20070259418 - Dna chip, dna chip kit, and method of manufacturing the dna chip: A DNA chip includes a substrate, at least one first electrode and at least one second electrode on the substrate, the first electrode and the second electrode being opposite to and separated from each other, multiple oligonucleotide probes, one end of the oligonucleotide probes being immobilized on the first electrode,... Agent: Lee & Morse, P.C.

20070259420 - Modulating photoreactivity in a cell: Photoreactivity in a cell is modulated by incorporating an isolated optical trigger on the surface or in the membrane of the cell. Exposure of a cell bearing incorporated optical triggers causes the generation of a measurable physiological signal.... Agent: Ut-battelle, LLC Office Of Intellectual Property

20070259419 - Pregnancy, up-regulated non-ubiquitous cam kinase: This invention relates generally to a novel CaM multi-functional protein kinase, which has been named Pregnancy Up-Regulated, Nonubiquitous CaM Kinase (PNCK), and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogeneous manner in certain subsets of cells, and overexpressed in... Agent: Montgomery, Mccracken, Walker & Rhoads, LLP

20070259421 - Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production: Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.... Agent: Knobbe Martens Olson & Bear LLP

20070259422 - Melanoma antigens and their use in diagnostic and therapeutic methods: The present invention provides a nucleic acid sequence encoding a melanoma antigen recognized by T lymphocytes, designated MART-1. This invention further relates to bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess or prognoses a mammal afflicted with melanoma or metastata melanoma. This invention... Agent: Leydig, Voit & Mayer, Ltd.

20070259423 - Method of differentiating stem cells into cells of the endoderm and pancreatic lineage: Methods are described to more efficiently produce cells of the endoderm and pancreatic lineage from mammalian pluripotent stem cells. These methods provide a simple, reproducible culture protocol using defined media components to enable consistent, large-scale production of pancreatic cell types for research or therapeutic uses.... Agent: Quarles & Brady LLP

20070259424 - Microfluidic device for cell separation and uses thereof: The invention features methods for separating cells from a sample (e.g., separating fetal red blood cells from maternal blood). The method begins with the introduction of a sample including cells into one or more microfluidic channels. In one embodiment, the device includes at least two processing steps. For example, a... Agent: Clark & Elbing LLP

20070259425 - Stem cell derived factors for treating pathologic conditions: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070259426 - Human foreskin fibroblasts for culturing es cells: A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.... Agent: Martin D. Moynihan Prtsi, Inc.

20070259427 - Modified surfaces for attachment of biological materials: The invention relates to bioactive surface coatings deposited on selected substrates. Surface nanostructured film coatings deposited on most metal or nonmetal substrates to provide surfaces can be engineered to promote enhanced tissue/cell adhesion. Attached cells, including osteoblasts, fibroblasts and endothelial cells, retain viability and will readily differentiate and proliferate under... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070259428 - Use of cloud point system in biotransformation: The invention relates to the field of microbial technology. It discloses a method to apply the cloud point system (CPS) in biotransformation by selecting one or more types of nonionic surfactant to form a aqueous system with a cloud point below the microbial transformation temperature, which serves as transformation medium.... Agent: Venable LLP

20070259429 - Adenoviral vectors having a protein ix deletion: This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant proteins and gene therapy also... Agent: Townsend And Townsend And Crew, LLP

20070259430 - Process for the removal of selectable marker gene sequences: The invention relates to a process for the removal of selectable marker gene sequences, in particular antibiotic gene sequences, from nucleic acid molecules. The invention further relates to the application of this process in the unlabelled integration and deletion of chromosomal genes and in controlling gene expression.... Agent: Nixon & Vanderhye, PC

20070254276 - Method and system for measuring membrane potential based on fluorescence polarization: A method of determining a membrane potential is disclosed. The method comprises (a) determining a difference in fluorescence polarization of a charged fluorescent probe being distributed across the membrane; and (b) determining a potential of the membrane, wherein the potential is proportional to the difference in the fluorescent polarization.... Agent: Martin D. Moynihan Prtsi, Inc.

20070254290 - Biomarkers for diagnosis of crescentic glomerulonephritis: This invention discloses a method for diagnosing Crescentic glomerulonephritis (CRGN) using at least a sample from a patient. The method is to find a least one biomarker for diagnosing Crescentic glomerulonephritis. The genetic performance of Sparc, Lcn2 and/or Spp1 can be used as biomarkers.... Agent: Birch Stewart Kolasch & Birch

20070254299 - Fungal delta 12 desaturase and delta 15 desaturase motifs: The present invention relates to fungal Δ12 desaturases (responsible for conversion of oleic acid to linoleic acid (18:2, LA)) and Δ15 fatty acid desaturases (responsible for conversion of LA to α-linolenic acid (18:3, ALA)). Amino acid motifs diagnostic of Δ12 desaturases and Δ15 desaturases are also provided. Methods of altering... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070254325 - Method and device for the determination of platelet function under flow conditions: The invention lies in the area of platelet function diagnostics and relates to a method for the determination of platelet function under flow conditions as well as a device for the implementation of this method. The method is particularly suitable for the determination of the effect of clopidogrel and of... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070254324 - Method for determination of platelet function under flow conditions: The invention lies in the area of platelet function diagnostics and relates to an in vitro method for the determination of platelet function under flow conditions. The method is particularly suitable for the determination of the effect of clopidogrel after oral intake and of other P2Y(12) antagonists with antithrombotic activity... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070254333 - Novel pyranose stereoisomers and method for producing unnatural sugars via palladium catalyzed glycosylation: The present invention can be a method to prepare a glycosylated natural product or pharmaceutical from either a BocO-pyranone or a BocO-enone. The identical methods of production utilize catalytic palladium and catalytic amounts of phosphine ligand to place the desired group stereospecifically at the C-1 position. The natural product can... Agent: West Virginia University Research Corporation

20070254338 - Method for making recombinant protein using complementation dependent dhfr mutants: The present invention relates to compositions and methods for making recombinant heteromeric proteins using a protein complementation assay employing complementation pairs of selectable markers.... Agent: Marshall, Gerstein & Borun LLP

20070254344 - Method of preparing a sugar chain library and use thereof: the sugar residues SA and SB are cleaved by different exoglycosidases, respectively] and libraries thereof, and methods of producing the same; methods of producing a sugar chain compound, which comprises treating the sugar chain compound or library with glycosidase, and glycosidase decomposition products obtained by the same; intermediates for the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070254277 - Automated systems for handling specimens for laboratory diagnostics and associating relevant information: An automated sorting system provides the ability to receive specimens for any number of diagnostic test procedures and to selectively transfer specimens to designated ones of a plurality of specimen processors based upon criteria of the laboratory facility such as the particular laboratory to perform the requisite diagnostic test, timing... Agent: Kagan Binder, PLLC

20070254278 - Photocurable perfluoropolyethers for use as novel materials in microfluidic devices: A functionalized photocurable perfluoropolyether is used as a material for fabricating a solvent-resistant microfluidic device. Such solvent resistant microfluidic devices can be used to control the flow of small amounts of a fluid, such as an organic solvent, and to perform microscale chemical reactions that are not amenable to other... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20070254279 - Single molecule drug discovery: The present application discloses methods and apparatuses for single molecule drug screening, discovery and validation. These methods and apparatuses allow a user to detect rapidly, using observation of single molecules, whether and how a drug candidate interferes with a target enzyme involved in a particular disease pathway. The methods and... Agent: Buchanan, Ingersoll & Rooney PC

20070254284 - A nucleic acid detection method: A nucleic acid detection method utilizing fluorescent reporter for real-time monitoring of amplification in a solid state where both forward and reverse primers are attached to a array with a plurality of primers.... Agent: Biwei Zhao

20070254298 - Atropisomers of asymmetric xanthene fluorescent dyes and method of dna sequencing and fragment analysis: Atropisomeric energy-transfer dye compounds are disclosed. A variety of molecular biology applications utilize atropisomeric xanthene fluorescent dyes as labels for substrates such as nucleotides, nucleosides, polynucleotides, polypeptides and carbohydrates. Methods include DNA sequencing, DNA fragment analysis, PCR, SNP analysis, oligonucleotide ligation, amplification, minisequencing, and primer extension.... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070254283 - Brhf1 as a cancer diagnostic marker: This invention relates generally to the discovery of a novel gene, designated BRHF1. The invention further relates to the detection of the BRHF1 gene, BRHF1 expression and/or the presence of the BRHF1 protein as potential markers for the early diagnosis of cancer.... Agent: Needle & Rosenberg, P.C.

20070254282 - Catalytic polynucleotide and its use for determination of analytes: A method for the determination of an analyte in a sample, the method comprising: (a) providing a catalytic polynucleotide; (b) contacting the catalytic polynucleotide with the sample so that the catalytic polynucleotide may bind to the analyte; (c) providing assay conditions such that the catalytic polynucleotide produces an optically detectable... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070254301 - Compositions and methods for detecting protease activity: The invention provides a method of determining activity of a protease. The method can include the steps of (a) providing a protease substrate including a protein moiety attached to a nucleic acid moiety and a ligand moiety; (b) contacting the protease substrate with a protease under conditions wherein the protease... Agent: Illumina, Inc.

20070254302 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Genentech, Inc.

20070254300 - Compositions and methods for treating inflammatory disorders: Protein complexes are provided comprising at least one interacting pair of proteins. The protein complexes are useful in screening assays for identifying compounds effective in modulating the protein complexes, and in treating and/or preventing diseases and disorders associated with the protein complexes and/or their constituent interacting members.... Agent: Myriad Genetics Inc. Intellecutal Property Department

20070254288 - Diagnostic methods for pain sensitivity and chronicity and for tetrahydrobiopterin-related disorders: Disclosed herein are methods for determining whether a subject possesses altered pain sensitivity an altered risk of developing acute or chronic pain, or diagnosing a tetrahydrobiopterin (BH4)-related disorder or a propensity thereto. These methods are based on the discovery of GCH1 and KCNS1 allelic variants that are associated with altered... Agent: Clark & Elbing LLP

20070254287 - Diagnostics and therapeutics for diseases associated with dipeptidyl-peptidase 10 (dpp10): The invention provides a human DPP10 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention... Agent: Banner & Witcoff, Ltd.

20070254291 - Gene targeting in eukaryotic cells by group ii intron ribonucleoprotein particles: Provided herein are methods of disrupting DNA substrates in eukaryotic cells and methods of introducing exogenous polynucleotides into target sites in the DNA substrates In certain embodiments the methods comprise introducing a purified group II intron ribonucleoprotein (RNP) particle into the host cell. In certain embodiments the method comprises introducing... Agent: Calfee Halter & Griswold, LLP

20070254289 - Genetic polymorphisms associated with alzheimer's disease, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with Alzheimer's Disease. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods... Agent: Celera Diagnostics, LLC

20070254296 - Genetic polymorphisms in the corticotropin-releasing hormone (crh) gene as markers for improving beef marbling score and/or subcutaneous fat depth: Aspects of the present invention also provide novel compositions and methods based on novel CRH single nucleotide polymorphisms selected from the group consisting of AAFC03076794.1:g.9657C>T, c.10718G>C, c.10841G>A, c.10893A>C and c.10936G>C, which may provide novel markers for marbling and/or subcutaneous fat depth. Additional aspects provide for novel methods which may comprise... Agent: Frommer Lawrence & Haug

20070254304 - Helicase-dependent amplification of nucleic acids: Methods and a kit are provided for selectively and exponentially amplifying nucleic acids and include the use of a helicase preparation and a DNA polymerase such that the amplification can be performed isothermally.... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20070254297 - Kcnq2 and kcnq3 - potassium channel genes which are mutated in benign familial neonatal convulsions (bfnc) and other epilepsies: Generalized idiopathic epilepsies (IGE) cause 40% of all seizures and commonly have a genetic basis. One type of IGE is Benign Familial Neonatal Convulsions (BFNC), a dominantly inherited disorder of newborns. A submicroscopic deletion of chromosome 20q13.3 which co-segregates with seizures in a BFNC family has been identified. Characterization of... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070254294 - Method for storing dna by using chitosan, and products using the methods: If DNA of human, animal, plant or bacteria, or a bio-sample containing DNA such as blood is well mixed with a water-soluble chitosan, and stored as a liquid state or a solid state using a solid medium such as a paper, it is possible to store DNA stably at room... Agent: Osha Liang L.L.P.

20070254293 - Method for the analysis of methylated dna: The present invention relates to a method for the analysis of methylated cytosines in DNA. In the first step of the invention unmethylated cytosines in the DNA to be analysed are chemically converted into uracil while 5-methylcytosines remain unchanged. In a second step a methylation specific oligonucleotide carrying a non-extendable... Agent: Kriegsman & Kriegsman

20070254292 - Method for trapping nucleic acids using divalent metal ions: A method for trapping nucleic acids on a surface of a solid phase substrate, which comprises the step of contacting a sample containing nucleic acids and having a pH of 12 or higher with the surface of the solid phase substrate on which divalent metal ions are immobilized, and a... Agent: Birch Stewart Kolasch & Birch

20070254306 - Method of determining genetic predisposition for deficiency in health functions using snp analysis: A method of determining genetic predisposition for deficiency in a specific health function of a person using single nucleotide polymorphism (SNP) analysis is provided. The method includes performing a SNP genotyping assay of three or more genes using a sample obtained from the person, obtaining a SNP panel which includes... Agent: Melvin K. Silverman

20070254280 - Method of identifying characteristic of molecules: The present invention is a method for identifying one or more characteristics of a target molecule, and comprises the steps of: converting the characteristics of the molecule into a polynucleotide of defined sequence, wherein each characteristic is represented by at least one distinct unit on the polynucleotide, the unit comprising... Agent: Marshall, Gerstein & Borun LLP

20070254303 - Methods for assessing the efficacy of treatment with a glucocorticoid: The invention relates to methods for assessing the efficacy of treatment with a glucocorticoid by determining the amount of MetAP-2.... Agent: Lahive & Cockfield, LLP

20070254295 - Methods of predicting and monitoring tyrosine kinase inhibitor therapy: The present invention provides methods for analyzing a combination of biomarkers to individualize tyrosine kinase inhibitor therapy in patients who have been diagnosed with cancer. In particular, the assay methods of the present invention are useful for predicting, identifying, or monitoring the response of a tumor, tumor cell, or patient... Agent: Townsend And Townsend And Crew, LLP

20070254305 - Methods of whole genome or microarray expression profiling using nucleic acids prepared from formalin fixed paraffin embedded tissue: The present invention provides novel methods for analyzing gene expression levels from fresh or aged (more than one year old) formalin-fixed, paraffin-embedded tissue (“FFPET”) samples that comprise pre-hybridizing a labeled nucleic acid sample prepared from the formalin-fixed, paraffin-embedded tissue sample with a first microarray, hybridizing the unbound labeled nucleic acid... Agent: Vinson & Elkins L.L.P.

20070254286 - Molecular markers that predict breast cancer development: A number of selected genes/gene products; Application of selected genes/gene products at mRNA or protein levels either singly or in combination; Application of selected genes/gene products at mRNA levels by any of the methods such as: Northern blotting, or reverse transcription and conventional PCR, or reverse transcription and quantitative real-time... Agent: Duane Morris, LLPIPDepartment

20070254281 - Specific marker lmx1a on dopaminergic neurons: The present invention identified Lmx1a genes, which are expressed in dopaminergic neurons at all differentiation stages, from proliferating dopaminergic neuron progenitor cells before cell cycle exit to cells after cell cycle exit. Lmx1a expression in cells can be used as an indicator when selecting cells suitable for transplantation therapy for... Agent: Townsend And Townsend And Crew, LLP

20070254285 - Stable water-soluble polyethylenimine conjugates and methods of use thereof: Water soluble, polyethylenimine polymers, conjugated to one or more active moiety are taught. Also taught are methods of making same, kits comprising same, and use of same in immunoassay systems.... Agent: Leydig Voit & Mayer, Ltd

20070254308 - Amplified array analysis method and system: The present invention concerns an array-based analytical system and method having an enhanced sensitivity which allows for simple and rapid analysis of relative unmodified samples which comprises an analytical system of the type having a plurality of different first members of a specific binding pair affixed in an array thereupon,... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

20070254307 - Method for estimation of location of active sites of biopolymers based on virtual library screening: A method and apparatus for estimating a location of one or more active sites on a target biopolymer molecular subset. The collective results for the likelihood of molecular combination between a collection of molecular subsets and the target biopolymer molecular subset are analyzed. The computational method utilizes an electrostatic affinity... Agent: Townsend And Townsend And Crew, LLP

20070254309 - Methods for assessing embryo viability: Methods for determining the viability of an embryo or an embryo precursor, comprising measuring the level of a polypeptide or peptide released by a cultured embryo or embryo precursor into the culture medium are disclosed. The polypeptide can be p53. Also disclosed are methods of ranking embryos on the basis... Agent: Woodcock Washburn LLP

20070254315 - Screening for neurotoxic amino acid associated with neurological disorders: Methods for screening for neurological disorders are disclosed. Specifically, methods are disclosed for screening for neurological disorders in a subject by analyzing a tissue sample obtained from the subject for the presence of elevated levels of neurotoxic amino acids or neurotoxic derivatives thereof associated with neurological disorders. In particular, methods... Agent: Pillsbury Winthrop Shaw Pittman LLP

20070254319 - Identification of a constitutively resistant cancer stem cell: In one embodiment, the invention provides a method of identifying and isolating a cancer MDR stem cell. In another embodiment, the invention provides an isolated cancer MDR stem cell and a population of such cells. In yet another embodiment, the invention provides a method of screening a test compound for... Agent: Leydig Voit & Mayer, Ltd

20070254318 - Inhibition of cell proliferation: The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer... Agent: Fish & Richardson P.C.

20070254317 - Method for detecting the activatable free form of psa and the use thereof for diagnosing benign pathologies of the prostate and adenocarcinoma of the prostate: The present invention relates to a method for the in vitro diagnosing of a benign pathology of the prostate or of an adenocarcinoma of the prostate, characterized in that it comprises the step consisting of detection, in a biological sample from a patient suspected of suffering from a benign pathology... Agent: Oliff & Berridge, PLC

20070254316 - Peptides for targeting the prostate specific membrane antigen: The invention provides isolated PSMA binding peptides, as well as pharmaceutical compositions thereof. Also provided are diagnostic and therapeutic methods utilizing the PSMA binding peptides, as well as methods for identifying further PSMA binding peptides.... Agent: Edwards Angell Palmer & Dodge LLP

20070254321 - Lytic enzymes and spore surface antigen for detection and treatment of bacillus anthracis bacteria and spores: Novel bacteriophages of Bacillus anthracis, the nucleic acids of its genome, nucleic acids comprising nucleotide sequences of open reading frames (ORFs) of its genome, and polypeptides encoded by the nucleic acids, are described. Therapeutic and diagnostic compositions, methods and kits related thereto are also provided.... Agent: Indianapolis Office 27879 Brinks Hofer Gilson & Lione

20070254320 - Method and kit for detecting listeria spp.: The subject invention is directed to a method and a kit for detecting Listeria spp. in food samples, biological sample (e.g., blood, saliva, tissue samples, cells samples, etc.), and any other sample suspected of containing Listeria.... Agent: Intellectual Property Department Dewitt Ross & Stevens, S.c.

20070254310 - Compositions and assays utilizing adp or phosphate for detecting protein modulators: Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high throughput system to obviate the... Agent: Townsend And Townsend And Crew, LLP

20070254311 - Covalent modification and conjugation of luciferase: A process for reversible chemical modification of the luciferase, a process for the covalent conjugation of a reversibly modified luciferase to a chemical moiety (a protein or a binding partner such as biotin or an antibody), a process for reactivation of the reversibly-modified and inactivated luciferase, a process for making... Agent: Leydig Voit & Mayer, Ltd

20070254313 - Gnal splice variant and uses thereof: The present invention relates to a novel splice form of the GNAL gene product and methods for identifying modulators of G protein coupled receptors.... Agent: Astra Zeneca Pharmaceuticals Lp Global Intellectual Property

20070254314 - Methods of treating autism and autism spectrum disorders: The present invention relates to methods of treating a subject diagnosed with autism or an autism spectrum disorder, lowering the level of mercury in a subject determined to contain a high level of mercury, methods of lowering the level of mercury in a child diagnosed with autism, lowering the level... Agent: Wood, Phillips, Katz, Clark & Mortimer

20070254312 - Protein kinase inhibitors and methods for identiying same: Inhibitors of protein kinase C (PKC)α, PKCδ and PKCζ are provided which are selective for those PKC isotypes. Combinatorial libraries for identifying protein kinases are also provided, as are methods of identifying protein kinases using those libraries. Additionally, methods of treating a mammal having a deleterious condition, where the condition... Agent: Amster, Rothstein & Ebenstein LLP

20070254322 - Complement-based analyte assay: An assay in which the presence or quantity of analyte in a sample is determined by treating the sample to form a reagent complex in which the analyte is bound to antibody to form an immune complex that is fixed by complement. The reagent complex is captured using complement antibody,... Agent: Klauber & Jackson

20070254323 - Malachite green derivatives for immunoassay reagents to detect malachite green: Compounds and procedures are provided for use in the preparation of reagents that can be used in immunoassays for Malachite Green, Leucomalachite Green and Carbinol. The compounds are Malachite Green Chromatic derivatives conjugated to several positions of the Malachite Green Chromatic structure, which in turn are conjugated to antigenic polypeptides... Agent: Meyertons, Hood, Kivlin, Kowert & Goetzel, P.C.

20070254326 - Method for detecting streptococcus agalactiae using esterase activity: The present invention concerns a method for specifically detecting and identifyng Streptococcus agalactiae, using a reaction medium comprising at least one esterase enzymatic substrate.... Agent: Oliff & Berridge, PLC

20070254328 - Glyoxylate assays and their use of inden tifying natural amidated compounds: Methods for detecting and assaying for glyoxylate, include enzyme-based assays and/or assays for hydrogen peroxide following liberation of hydrogen peroxide from glyoxylate, are disclosed. In some embodiments, the invention is directed to methods for assaying for glyoxylate produced by the reaction of peptidylglycine alpha-amidating monooxygenase (PAM). The subject invention also... Agent: Ostrolenk Faber Gerb & Soffen

20070254327 - Method for performing the hot start of enzymatic reactions: The present invention provides processes for controlling the start of an enzymatic reaction, which is catalysed by a metal ion dependent enzyme. The required metal ion is generated by a redox reaction initiated by heating a metal compound having a metal atom or metal ion with a redox agent. Also... Agent: Nixon & Vanderhye, PC

20070254329 - Mammalian genes involved in viral infection and tumor suppression: The present invention provides methods of identifying cellular genes used for viral, bacterial or parasitic growth. Also provided by the present invention are nucleic acids related to and methods of reducing or preventing viral, bacterial or parasitic infection.... Agent: Needle & Rosenberg, P.C.

20070254331 - Reagent for analyzing urine and method for analyzing urine: A reagent for analyzing urine is described. The reagent comprises a fungus membrane damaging agent for damaging a cellular membrane of yeast-like fungus in urine; a first dye for staining yeast-like fungus so that a fluorescent intensity of damaged yeast-like fungus becomes more intense than that of erythrocyte in urine;... Agent: Sughrue Mion, PLLC

20070254330 - Use of isogenic drug-resistant cell lines to determine the sequence of chemotherapeutic drug treatment: The present invention provides isogenic cell lines and uses said isogenic cell lines in a method for determining a sequence to administer multiple types of chemotherapeutic drugs for killing cancerous cells to reduce the induction of drug cross-resistance in a patent. The methods also involves screening drug candidates to select... Agent: Mr. Adrian Zahl Ridout & Maybee LLP

20070254332 - Method for readily detecting class c beta-lactamase-producing bacteria: A method for determining whether a test bacterium is a class C beta-lactamase-producing bacterium. Spots of a class C beta-lactamase inhibitor and a beta-lactam drug are applied at an interval on the surface of a solid medium that has been coated with the test bacterium, the solid medium is cultured,... Agent: Greenblum & Bernstein, P.L.C

20070254335 - novel expression vector system regulated by sigma32 and methods for using it to produce recombinant protein: This invention discloses an expression vector system comprising a promoter recognized and regulated by a heat shock sigma factor of E. coli, especially σ32 . Preferably, the promoter comprises the consensus sequence of E. coli heat shock promoters as shown in SEQ ID NO:1. Also disclosed are methods for producing... Agent: Baker Donelson Bearman Caldwell & Berkowitz, PC

20070254337 - Escherichia coli strains which over-produce l-threonine and processes for the production of l-threonine by fermentation: The present invention relates to the fields of microbiology and microbial genetics. More specifically, the invention relates to novel bacteria strains and processes employing these strains for the fermentative production of amino acids such as threonine.... Agent: Craig G. Cochenour, Esquire Buchanan Ingersoll & Rooney PC

20070254334 - Prokaryotic host cells for expressing proteins rich in disulfide bonds: The invention provides composition and methods for producing proteins of interest which comprise at least one disulfide bond, include proteins which in their mature form do not contain disulfide bonds, but whose precursor molecule contained at least one disulfide bond. The methods employ a host cell modified to more efficiently... Agent: Foley Hoag, LLP Patent Group (w/huv Hmv)

20070254336 - Transcription factors: The present invention relates to an isolated nucleic acid sequence coding for a PntR transcription factor comprising a nucleotide sequence that is the same as, or is complementary to, or contains any suitable codon substitutions for any of those of SEQ ID NOs: 1, 3 or 5 or comprises a... Agent: Frommer Lawrence & Haug

20070254339 - Tetramerizing polypeptides and methods of use: The present invention relates to a method of preparing a tetrameric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a vasodialator-stimulated phosphoprotein (VASP) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion... Agent: Zymogenetics, Inc. Intellectual Property Department

20070254340 - Cytokine protein family: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral... Agent: Zymogenetics, Inc. Intellectual Property Department

20070254341 - Biochemical synthesis of 6-amino caproic acid: The invention relates to biochemical synthesis of 6-amino caproic acid from 6-aminohex-2-enoic acid compound or from 6-amino-2-hydroxyhexanoic acid, by treatment with an enzyme having α,β-enoate reductase activity towards molecules containing an α,β-enoate group and a primary amino group. The invention also relates to processes for obtaining suitable genetically engineered cells... Agent: Nixon & Vanderhye, PC

20070254343 - Method of generating long nucleic acid molecules of defined sequence: A method of generating a single-stranded nucleic acid molecule comprising (a) combining in a mixture under conditions suitable for a polymerase extension reaction, (i) a polymerase, (ii) an initial polynucleotide comprising a 5′ portion and a 3′ portion, wherein the polynucleotide forms the nucleic acid molecule 5′ end; and (iii)... Agent: Harness, Dickey & Pierce, P.L.C

20070254342 - Process for plasmid dna fermentation: Improvements in plasmid DNA production technology are needed to insure the economic feasibility of future DNA vaccines and DNA therapeutics. General methods are described, by means of which it is possible to dramatically increase plasmid DNA productivity in a fermentor. These processes feature Fed-batch fermentation strategies, combined with novel growth... Agent: Brooks Kushman P.C.

20070254345 - L-amino acid-producing bacterium and a method for producing l-amino acid: Coryneform bacteria are described that have an ability to produce L-amino acids and are modified so that acetyl-CoA hydrolase activity is decreased. The bacteria are used to produce L-amino acids generated by a biosynthetic pathway in which pyruvic acid is an intermediate, such as L-glutamic acid, L-arginine, L-glutamine, L-proline, L-alanine,... Agent: Cermak & Kenealy LLP Acs LLC

20070254346 - Process for producing farnesylated dibenzodiazepinone by fermentation: The present invention provides a scalable process for producing a concentrate containing a mass of a farnesylated dibenzodiazepinone by fermenting in an aqueous culture medium a strain of a microorganism that is capable of producing the farnesylated dibenzodiazepinone, upon completion of fermentation harvesting the fermentation broth and extracting the fermentation... Agent: Merchant & Gould PC

20070254347 - Method for producing vitamin k2 from culture of bacillus natto: A method for producing vitamin K2 comprising: culturing Bacillus natto in a liquid medium to obtain a Bacillus natto culture or culture supernatant thereof, wherein the culture or culture supernatant contains vitamin K2; treating the culture or culture supernatant with at least one coagulant selected from the group consisting of... Agent: The Webb Law Firm, P.C.

20070254348 - Method for the production of fermentable sugars and cellulose from lignocellulosic material: A method for the production of fermentable sugars and cellulose from lignocellulosic material in a batch or continuous process. Lignocellulosic material is fractionated in a fashion that cellulose is removed as pulp, cooking chemicals reused, lignin is separated for the production of process energy, hemicelluloses are converted into fermentable sugars,... Agent: American Process Inc Steve Rutherford

20070254349 - Preparation for the photodynamic control of micro-organisms and use thereof: The invention relates to a preparation for the photodynamic control of micro-organisms, said preparation being in a liquid or pasty form and containing a photosensitiser which comprises a dyestuff and produces singlet oxygen when irradiated by means of light. The micro-organisms can be marked by means of the dyestuff. The... Agent: Jordan And Hamburg LLP

20070254350 - Modulation of inhibition of ferrochelatase by n-methyl protoporphyrin: Provided herein, is a means for development of ferrochelatase variants with improved tolerance towards N-methyl protoporphyrin. Also disclosed are cell assay systems utilizing the variants, as the variants would confer resistance to N-methyl protoporphyrin inhibition and thereby keep heme synthesis uninterrupted. The variants contain loop mutations that affect the NMPP-ferrochelatase... Agent: Smith Hopen, Pa

20070254351 - Method for the preparation of purified hcv rna by exosome separation: The invention relates to a method for isolation of hepatitis C virus. The method comprises the separation of particles termed exosomes from the blood plasma of an individual infected with hepatitis C virus (HCV) and the extraction or RNA from these exosome particles.... Agent: Novartis Vaccines And Diagnostics Inc.

20070254352 - Methods for purifying adeno-associated virus particles: The present invention provides methods of purifying encapsidated virus, e.g., viral particles comprising viral nucleic acid, from compositions comprising encapsidated viral nucleic acid and viral particles that lack viral nucleic acid; methods for reducing the particle:genome ratio in a preparation of encapsidated viral nucleic acid; and methods for selectively inactivating... Agent: Bozicevic, Field & Francis LLP

20070254353 - Frozen lactic acid bacteria culture of individual pellets: A frozen lactic acid bacteria (LAB) culture in a commercial relevant package that has a weight of at least 50 g frozen material, wherein the frozen material is present in the form of individual pellets characterized by that when stored at −50° C. for 7 days the individual pellets of... Agent: Foley And Lardner LLP Suite 500

20070254354 - Production of isoprenoids: The invention provides a biological method of producing isoprenoids.... Agent: Sheridan Ross PC

20070254355 - Improved nitroreductase enzymes for bioremediation: Compositions and methods are provided for bioremediation of toxic metals.... Agent: Bozicevic, Field & Francis LLP

20070254356 - Cell culture methods and devices utilizing gas permeable materials: Gas permeable devices and methods are disclosed for cell culture, including cell culture devices and methods that contain medium at heights, and certain gas permeable surface area to medium volume ratios. These devices and methods allow improvements in cell culture efficiency and scale up efficiency.... Agent: Patterson, Thuente, Skaar & Christensen, P.A.

20070254357 - Gene therapy using replication competent targeted adenoviral vectors: This invention provides a method of treating cancer by administering a replication competent adenoviral vector comprising a therapeutic gene and a disease specific gene regulatory region operationally linked to at least one replication gene. The replication competent targeted adenoviral vector preferentially replicates in the tumor cells following activation of the... Agent: Townsend And Townsend And Crew, LLP

20070254358 - Culture medium for cell growth and transfection: The present invention is directed generally to cell culture media (particularly serum free, non animal derived, and/or chemically defined media) which are useful for introducing macromolecules and compounds (e.g., nucleic acid molecules) into cells (e.g., eukaryotic cells). According to the invention, such introduction can take place in the presence of... Agent: Invitrogen Corporation C/o Intellevate

20070254359 - Differentiation of human embryonic stem cells: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem... Agent: Philip S. Johnson Johnson & Johnson

20070254360 - Human toll homologues: The invention relates to the identification and isolation of novel DNAs encoding the human Toll proteins PR0285, PR0286, and PR0358, and to methods and means for the recombinant production of these proteins. The invention also concerns antibodies specifically binding the PR0285, or PR0286, or PR0358 Toll protein.... Agent: Gates & Cooper LLP Howard Hughes Center

20070254361 - Method for expansion of human corneal endothelial cells: A method for expanding human corneal endothelial cells includes: (a) providing an amniotic membrane with or without amniotic cells, wherein the amniotic membrane has an extracellular matrix; (b) placing onto the amniotic membrane, a sheet of endothelial layer, or a cell suspension including human corneal endothelial stem cells; and (c)... Agent: Akin Gump Strauss Hauer & Feld L.L.P.

20070254362 - Compositions and methods employing universal-binding nucleotides for targeting multiple gene variants with a single sirna duplex: Provided are siRNA molecules of between about 15 base-pairs and about 40 base-pairs comprising one or more universal-binding nucleotide such as inosine, 1-β-D-ribofuranosyl-5-nitroindole, and 1-β-D-ribofuranosyl-3-nitropyrrole, compositions comprising one or more universal-binding nucleotide comprising siRNA, and methods for making and for using such universal-binding nucleotide comprising siRNA molecules to increase the... Agent: Nastech Pharmaceutical Company Inc

20070254364 - Methods and compositions for treating disorders involving excitotoxicity: It is shown here that hedgehog polypeptides possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons and other neurons which are sensitive to exotoxicity.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070254363 - Substituted biaryl compounds for inflammation and immune-related uses:

20070254366 - Soybean variety 4247825: The invention relates to the soybean variety designated 4247825. Provided by the invention are the seeds, plants and derivatives of the soybean variety 4247825. Also provided by the invention are tissue cultures of the soybean variety 4247825 and the plants regenerated therefrom. Still further provided by the invention are methods... Agent: Fulbright & Jaworski, L.L.P.

20070254365 - Soybean variety 4878185: The invention relates to the soybean variety designated 4878185. Provided by the invention are the seeds, plants and derivatives of the soybean variety 4878185. Also provided by the invention are tissue cultures of the soybean variety 4878185 and the plants regenerated therefrom. Still further provided by the invention are methods... Agent: Fulbright & Jaworski, L.L.P.

20070254367 - Methods for extending the life span of marine invertebrate cells: The subject invention provides materials and methods for extending the life span and/or immortalizing marine invertebrate cell lines. Specifically exemplified herein are methods for extending the life spans for sponges, cnidarians, mollusks and ascidians. In a preferred embodiment exemplified herein, the cells whose lives are extended are marine sponge cells.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070254368 - Method for simultaneous display of target protein and cofactor regenerating enzyme on cell surface: The present invention relates to a method for simultaneously surface expressing a target protein using a cofactor and an enzyme regenerating the cofactor on the cell surface. According to the present invention, it is possible to provide a microorganism capable of simultaneously surface expressing a target protein using a cofactor... Agent: Moore & Van Allen PLLC