Chemistry: molecular biology and microbiology inventions 11/07

20070275389 - Array design facilitated by consideration of hybridization kinetics: Methods, systems and computer readable media for selecting probes for design of a chemical array. A first set of candidate probes is provided for hybridization with a sample at a first hybridization stringency and a second set of candidate probes identical to the first set is provided for hybridization with... Agent: Agilent Technologies Inc.

20070275388 - Dendrimers that possess a single target annealing site and uses thereof: Provided is a polynucleotide dendrimer having a single unique binding site for binding a target molecule, thereby permitting stoichiometric quantification of the dendrimer-bound target molecule. The dendrimer of the invention is useful in conjunction with various methods for detecting, and optionally quantifying, nucleic acids, proteins, polysaccharides, organic compounds, or antigens,... Agent: Agilent Technologies Inc.

20070275411 - Silane mixtures: Silanation compositions containing a mixture of two or more silanation reagents, where at least one silanation reagent includes a functional group capable of supporting polymer synthesis and at least one silanation reagent includes no functional group capable of supporting polymer synthesis are useful in modulating the active site density and... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070275428 - Protein phosphorylation imaging systems, methods of making phosphorylation imaging systems, and methods of use thereof: Briefly described, embodiments of this disclosure include phosphorylation sensing systems, methods of detecting phosphorylation, noninvasive methods for detecting the interaction of a first protein with a second protein within a living animal, fusion proteins including the phosphorylation sensing system, vectors including the phosphorylation sensing system, kits including the phosphorylation sensing... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070275363 - Bioreactor for organ reconstruction and augmentation: Bioreactors are used in neo-organ production to allow for an appropriate environment for the maintenance of healthy culturing conditions from pre-wetting to shipment of the neo-organ. The closed system “all-in-one bioreactor” is designed to allow for minimal exposure of the scaffold to the open air in order to maintain sterility.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070275362 - Placental stem cell populations: The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.... Agent: Jones Day

20070275364 - Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070275365 - Human corneal endothelial cells and methods of obtaining and culturing cells for corneal cell transplantation: A method for isolation of human corneal endothelial cells by non-enzymatic harvesting and culturing of endothelial cells in vitro from critical density in a system consisting of extracellular matrix protein coated plastic dishes and growth factor enriched culture medium are used to generate expanded sub-populations of endothelial cells for cell... Agent: Jacobson Holman PLLC

20070275366 - Regulation of sperm function: An extracellular matrix protein, such as fibronectin, vitronectin or laminin, is added to a sperm sample to bring the sperm into a low motility, non-capacitated state or maintain a pre-existing non-capacitated state. Subsequently, at an appropriate time in an in vitro fertilization study or in vivo fertilization procedure, angiotensin II... Agent: Fish & Richardson PC

20070275367 - Type lectin fold as a scaffold for massive sequence variation: This invention provides a class of binding proteins with a range of binding specificities and affinities based upon variation at select amino acid positions within a scaffold. The variable positions may be readily modified to produce a library of binding proteins with different binding specificities and affinities. The library may... Agent: Townsend And Townsend And Crew, LLP

20070275371 - Colorimetric sensor using polydiacetylene supramolecule: There is provided a polydiacetylene supramolecule comprising diacetylene molecules, capable of immobilizing a receptor molecule having a thiol group. Since the polydiacetylene supramolecule has a receptor immobilized thereon having a thiol group, for example, an antibody, and thus shows color transition when reacting with a sample, an antigen can be... Agent: Kenyon & Kenyon LLP

20070275369 - Detection of molecular interactions: A method and assay are described for measuring the interaction between a ligand and an analyte. The assay can include a suspension of colloidal particles that are associated with a ligand of interest. The colloidal particles are maintained in the suspension at or near a phase transition state from a... Agent: Knobbe Martens Olson & Bear LLP

20070275370 - Method for detecting concentrations of a target bacterium that uses phages to infect target bacterial cells: The invention is directed to a method for detecting low concentrations of bacteria in liquid solution that may or may not be complex liquid solutions. In one embodiment, immunomagnetic separation (IMS) is used to separate target bacterium that may be in a liquid mixture from other constituents in the mixture.... Agent: Dorsey & Whitney, LLP Intellectual Property Department

20070275372 - Methods and reagents for molecular detection of hiv-1 groups m, n and o: Reagents and assays for detecting HIV-1 groups M and O and optionally HIV-1 group N and SIVcpz are provided. The reagents are nucleic acid primers for the hybridization to, amplification and subsequent detection of HIV-1 groups M, N and O and SIVcpz in a biological sample. The primers are oligonucleotides... Agent: Klarquist Sparkman, LLP

20070275368 - Posh associated kinases and related methods: The application provides novel complexes of POSH polypeptides and POSH asoociated kinases. The application also provides methods and compositions for treating a POSH-associated diseases such as viral disorders and cancer.... Agent: Ropes & Gray LLP Patent Docketing 39/41

20070275382 - Biomarkers for the efficacy of somatostatin analogue treatment: Gene expression assays were performed using tissues of monkeys treated with the somatostatin analogue pasireotide at sub-therapeutic dose for 14 days. The assays were analyzed to identify the modes of actions of pasireotide with relationships to therapeutic applications. The effects on the growth hormone/IGF-1 and glucagon/insulin axes were reflected in... Agent: Novartis Corporate Intellectual Property

20070275381 - Chromosome 5 genetic variants related to dyslexia: An isolated polynucleotide or genetic material from human Chromosome 5 that indicates the presence of dyslexia or a predisposition to develop dyslexia in the individual from whom the sample was obtained. A method of diagnosing dyslexia or a predisposition to develop dyslexia.... Agent: Sheldon Mak Rose & Anderson PC

20070275393 - Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains: A novel family of protein libraries comprising CTLDs (C-type Lectin-Like Domains) in which internal polypeptide loop-regions lining the ligand binding sites in CTLDs have been replaced with ensembles of completely or partially randomised polypeptide segments. Tetranectin CTLDs were chosen as framework for the preferred embodiment of the invention; and versatile... Agent: Roberts, Mlotkowski & Hobbes

20070275396 - Detection of dna hybridization with a carbon nanotube label: Methods are provided for the detection and identification of target nucleic acids using a system comprising a nanotube—nucleic acid complex. The complex is comprised of a singly dispersed carbon nanotube and a dispersant nucleic acid molecules that is associated with the carbon nanotube in a non-covalent fashion. Portions of the... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070275397 - Detection of molecular interactions using a reduced affinity enzyme complementation reporter system: Methods and compositions for detecting molecular interactions are provided. Aspects of the invention include the use of a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments of the methods.... Agent: Bozicevic, Field & Francis LLP

20070275403 - Diagnostic methods for determining treatment: The present invention provides methods for identifying cancer patients susceptible to effective treatment with inhibitors of the tyrosine kinase activity of EGFR. The invention is based on the discovery that polysomy of chromosome 7 can be used to selectively identify cancer patients that are likely to be successfully treated with... Agent: Kevin M. Farrell Pierce Atwood

20070275404 - Gene expression signatures associated with tumor stromal cells: Methods are provided for classification of solid tumors other than soft tissue tumors; e.g. carcinomas. The tumor mass of such cancers comprises neoplastic cells of epithelial origin, and surrounding stroma. Methods are provided for classification and analysis of such tumors based on the gene expression signature of the tumor stromal... Agent: Bozicevic, Field & Francis LLP

20070275398 - Genes involved estrogen metabolism: The invention concerns genes that have been identified as being involved in estrogen metabolism, and are useful as diagnostic, prognostic and/or predictive markers in cancer. In particular, the invention concerns genes the tumor expression levels of which are useful in the diagnosis of cancers associated with estrogen metabolism, and/or in... Agent: Heller Ehrman LLP

20070275377 - Isolated photoprotein mtclytin, and use thereof: The invention relates to the photoprotein mtClytin, to its nucleotide and amino acid sequences and to the activity and use of the photoprotein mtClytin.... Agent: Jeffrey M. Greenman

20070275375 - Means and method for the detection of target nucleotide sequences using ligation assays with improved oligonucleotide probe pairs: A pair of oligonucleotide probes comprising a first oligonucleotide probe that comprises a first clamp section that is capable of hybridising to a second clamp section of a second oligonucleotide probe and a first target section that is capable of hybridising to a first section of a target DNA sequence... Agent: Mckenna Long & Aldridge

20070275405 - Member for producing a probe array and probe array producing method: In order to provide a member for producing a probe array that allows producing desired probe arrays immediately once the probe arrangement is established, and to provide a probe array producing method that uses this member for producing a probe array, the pieces F1, F2 . . . Fn are... Agent: Posz Law Group, PLC

20070275380 - Method for distinguishing aml subtypes with aberrant and prognostically intermediate karyotypes: Disclosed is a method for distinguishing AML subtypes with aberrant and prognostically intermediate karyotypes selected from trisomy 8, inv(3), t(3;3), trisomy 11, trisomy 13, trisomy 4, t(1;3), t(6;9), der(5)t(5;11), i(17), del(9q), del(12p), and/or del(20q) in a sample by determining the expression level of markers, as well as a diagnostic kit... Agent: Clark & Elbing LLP

20070275373 - Method of fingerprinting tissue samples: The present invention is directed to methods of determining a copy number of nucleic acids in a biological specimen. More specifically, the invention provides a method for determining an absolute copy number of a transcript or a plurality of transcripts of interest in a biological specimen the size of which... Agent: David S Resnick Nixon Peabody

20070275399 - Methods for calculating codon pair-based translational kinetics values, and methods for generating polypeptide-encoding nucleotide sequences from such values: Provided are methods for calculating codon pair translational kinetics values, creating a synthetic gene for expression in a host organism, and providing codon pair translational kinetic values. The methods typically are directed to refinement of statistical observed versus expected codon pair frequencies using one of several factors such as amino... Agent: Knobbe Martens Olson & Bear LLP

20070275407 - Methods for determining therapeutic index from gene expression profiles: This invention provides methods for determining drug specificity, therapeutic index and effective doses for individual patients. According to the methods of the invention, graded levels of drug are applied to a biological sample or a patient. A plurality of cellular constituents are measured to determine the activity of the drug... Agent: Jones Day

20070275374 - Methods for idendifying drug targets and modulators of neurons and compositions comprising the same: The invention provides methods of identifying drug targets in dopaminergic and/or noradrenergic neurons and to the drug targets identified by such methods. This invention also provides a method of screening for agents that modulate dopaminergic neurons and/or noradrenergic neuron activity, function and/or drug target expression, and agents that bind drug... Agent: Morrison & Foerster LLP

20070275406 - Methods for producing ex vivo models for inflammatory disease and uses thereof: The invention relates to methods for inducing a pro-asthma/pro-inflammatory like state in a resident tissue cell, comprising contacting the cell with one or more cytokines, e.g., IL-β, TNFα or both. Methods are also disclosed for identifying genes that regulate responses to anti-inflammatory drugs, to methods for drug screening, and to... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070275392 - Microrna motifs: Disclosed are methods of identifying microRNA motifs or microRNA precursors for a target gene or a set of target genes. Also disclosed are related computer-readable media.... Agent: Fish & Richardson PC

20070275400 - Multivariate random search method with multiple starts and early stop for identification of differentially expressed genes based on microarray data: The present invention provides multivariate methods for analyzing microarray gene expression data of high dimensional space and thereby identifying differentially expressed genes. The methods of this invention provide a random search procedure with multiple starts and early stop. Larger sets of differentially expressed genes may be identified using the methods... Agent: Needle & Rosenberg, P.C.

20070275384 - Mutant sodium channel nav1.7 and methods related thereto: Described are mutant Nav1.7 sodium channel alpha-subunits and nucleic acid sequences encoding such mutants. Further described are methods for characterizing a nucleic acid sequence that encodes a Nav1 sodium channel alpha-subunit, methods for determining a Nav 1.7 haplotype, methods for determining a subject's predisposition to a neurologic disorder associated with... Agent: Needle & Rosenberg, P.C.

20070275391 - Novel g-protein coupled receptors and dna sequences thereof: The present invention relates to in particular immune modulatory polypeptides and polynucleotides, recombinant materials and methods for their production. Such polypeptides and polynucleotides are of interest in relation to methods of treatment of diseases whereby immune responses initiated by dendritic cells (DC), monocytes or lymphocytes, play a causal or contributory... Agent: Novartis Corporate Intellectual Property

20070275383 - Novel hybrid probes with heightened luminescence: Hybrid probe particles comprising a nanoparticle of gold of diameter in the range extending from 2 to 30 nm on the surface of which, on the one hand, at least one, and preferably from one to 100, organic probe molecules are grafted by gold-sulphur bonds and on the other hand,... Agent: Clark & Brody

20070275402 - Novel markers for prenatal diagnosis and monitoring: This application provides the use of novel fetal markers for prenatal diagnosis and monitoring of certain pregnancy-related conditions. More specifically, the invention resides in the discovery that certain CpG islands located on fetal chromosome 21 demonstrate a methylation profile that is distinct from that of the corresponding CpG islands located... Agent: Townsend And Townsend And Crew, LLP

20070275394 - Nucleic acid nanostructure and method of manufacturing the same: Provided are a nucleic acid nanostructure including: a substrate; a nucleic acid quadruplex immobilized on the substrate to be vertical with respect to the substrate; a metal ion present in a unit lattice of the nucleic acid quadruplex, the unit lattice being made up of eight nucleobases; and a nanoparticle... Agent: Ladas & Parry LLP

20070275387 - Photocleavable fluorescent nucleotides for dna sequencing on chip constructed by site-specific coupling chemistry: This invention provides a method for determining the sequence of a DNA or an RNA, wherein (i) about 1000 or fewer copies of the DNA or RNA are bound to a solid substrate via 1,3-dipolar azide-alkyne cycloaddition chemistry and (ii) each copy of the DNA or RNA comprises a self-priming... Agent: Cooper & Dunham, LLP

20070275390 - Polymorphisms in fatty acid binding protein 4 (''fabp4'') gene and their associations with carcass traits: The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention relates to the identification of single nucleotide polymorphisms (SNPs) within the bovine... Agent: Frommer Lawrence & Haug

20070275386 - Polymorphisms in the epidermal growth factor receptor gene promoter: The present invention concerns polymorphisms in the epidermal growth factor receptor (EGFR), gene. In some embodiments, the present invention is directed at compositions and methods involving single nucleotide polymorphisms (SNPs) in the promoter of the EGFR gene that affect EGFR expression. The identification of polymorphisms associated with EGFR expression or... Agent: Fulbright & Jaworski L.L.P.

20070275378 - Rapid determination and quantification of mycoplasma contamination using dna chip technology: Disclosed is a method for detecting a microorganism contamination in a culture of eukaryotic cells to be used for gene expression profiling, by using a microarray which has attached on its surface at least one nucleic acid probe representing a gene of a eukaryotic cell and at least one nucleic... Agent: Foley And Lardner LLP Suite 500

20070275385 - Rapid screening method of translational fusion partners for producing recombinant proteins and translational fusion partners screened therefrom: Disclosed are a method for rapid screening suitable translational fusion partners (TFPs) capable of inducing expression or secretory production of non-producible proteins, which are difficult to produce in conventional recombinant production methods, from a variety of genetic sources, and protein secretion-inducing TFPs obtained using the method.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070275379 - Simian orl1 gene and method of assessing compound: A nucleic acid having a base sequence of SEQ ID NO. 1; a protein having an amino acid sequence of SEQ ID NO. 2; a recombinant vector comprising a gene constituted of the above nucleic acid; and a transformant cell comprising the recombinant vector. By the use of these, it... Agent: Merck And Co., Inc

20070275395 - Tagged monomers for use in sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070275376 - Tumor-specific expression of reporter genes: A reporter gene operably linked to a transcriptional control element that is up-regulated by a tumor-induced transcription factor is disclosed. This reporter gene construct can be used to detect tumor formation in vivo in an experimental animal.... Agent: Ropes & Gray LLP Patent Docketing 39/361

20070275401 - Use of mx gtpases in the prognosis and treatment of cancer: The invention provides a method of reducing cancer progression comprising administering a Mx polypeptide or Mx-encoding nucleic acid to a host, such that the growth rate of the cancer cells is reduced, the metastatic potential of the cancer cells is reduced, or both. The invention also provides a method of... Agent: Leydig, Voit & Mayer, Ltd.

20070275412 - Chondroitin sulfate binding proteins and modulators thereof: Chondroitin sulfate polysaccharides with defined sulfation patterns can be synthesized. These chondroitin polysaccharides can be used to identify chondroitin sulfate binding proteins. Further, compounds that modulate the activity of chondroitin sulfate binding proteins can be identified. For example, TNF-α was found to bind specifically to CS-E and CS-E can be... Agent: Knobbe Martens Olson & Bear LLP

20070275413 - Enumeration of cd4+lymphocytes: The invention provides a method of enumerating the number of cells of a cell type in a cell sample by (a) counting the white blood cells in the cell sample to obtain the white blood cell population of the sample; (b) determining the proportion or percentage of the cells of... Agent: Buchanan, Ingersoll & Rooney PC

20070275410 - Methods and compositions relating to modulation of gpcr signaling: The subject invention provides methods for detecting a GPCR-binding partner complex. In general, the methods involve co-producing two polypeptides, one of which being a GPCR, isolating one of the polypeptides using a substrate with affinity for that polypeptide, and directly detecting the presence of the other polypeptide on the substrate.... Agent: Arena Pharmaceuticals, Inc.

20070275409 - Methods for detecting and analyzing n-glycolynlneuraminic acid (neu5gc) in biological materials: The present application is in the field of sialic acid chemistry, metabolism and antigenicity. More particularly, the present invention relates to the detection and analysis of the non-human sialic acid, N-glycolylneuraminic acid (Neu5Gc) in bio-logical materials, such as food and clinical specimens. Such detection and analysis is facilitated by the... Agent: Axford Laurie Gorddon & Rees

20070275408 - Synthetic bioelastomer: A bioelastomer which is a polypeptide comprising a plurality of repeat units in which the consensus sequence SSXXYGXP, where S is serine, X is an unspecified amino acid, Y is tyrosine, G is glycine and P is proline, is present and which is cross-linked through dityrosine bond formation, with the... Agent: Sughrue Mion, PLLC

20070275417 - Cd4+ epitopes of bone morphogenetic proteins: The present invention provides CD4+ T-cell epitopes in bone morphogenetic proteins (BMPs). In particular embodiments, the present invention provides CD4+ T-cell epitopes of BMP-7 and BMP-14. In some preferred embodiments, the present invention provides CD4+ T-cell epitopes of BMP-7 and BMP-14 that are suitable for modification to reduce the immunogenicity... Agent: Kamrin T. Macknight Genencor International, Inc.

20070275418 - Monoclonal antibodies with specificity for fetal erythroid cells: The present invention concerns a monoclonal antibody and corresponding hybridoma cells and antigens suitable for isolating fetal cells from maternal blood. The monoclonal antibody reacts with a surface antigen present on fetal red blood cells including their nucleated precursor cells, but not with surface antigens on adult erythroid cell.... Agent: Fulbright & Jaworski L.L.P.

20070275421 - Detection of dysplastic or neoplastic cells using anti-mcm2 antibodies: Determination of cellular growth abnormality, particularly cancerous abnormality, by detection of target polypeptides or encoding mRNA, where the target polypeptides are members of the preinitiation complex of DNA replication in tissue, cells or fluid. Target polypeptides include CDC6, MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7. Test samples include tissue of... Agent: Nixon & Vanderhye, PC

20070275420 - Method for detecting prognosis of cancer: It is to provide a method and a kit for detecting the prognosis of cancer at high accuracy in a simple and rapid manner at low cost. The method is specifically a method for detecting the prognosis of cancer, at least including a step of detecting core-2 β 1,6-acetylglucosaminyltransferase in... Agent: Sughrue Mion, PLLC

20070275422 - Methods and compositions for detecting pancreatic disease: Methods and compositions for at least determining whether a human subject has a pancreatic disease are provided. In practicing the subject methods, a sample from a subject is assayed for a pancreatic glycoprotein (GP2) analyte to determine whether the subject at least has the pancreatic disease. Also provided are kits,... Agent: Bozicevic, Field & Francis LLP

20070275419 - Tumor tag and the use thereof: The invention provides a new tumor tag, RL5 protein, the polynucleotide encoding RL5 protein, and the method of producing RL5 protein by recombinant technology. The invention also discloses the use of RL5 protein and the polynucleotides encoding RL5 protein, e.g., in diagnosing and treating tumor, as well as the pharmaceutical... Agent: Wilson Sonsini Goodrich & Rosati

20070275415 - Droplet-based affinity assays: The present invention relates to droplet-based affinity assays. According to one embodiment, a method of detecting a target analyte in a sample is provided, wherein the method includes: (a) executing droplet operations to combine affinity-based assay reagents on a droplet microactuator with a sample potentially comprising the target analyte to... Agent: Ward And Smith, P.A.

20070275414 - Method of detecting thrombosis by measuring von willenbrand factor-cleaving protease: A method of detecting thrombosis or the degree of thrombophilia by measuring a von Willebrand factor cleaving protease, and a kit for detecting thrombosis or the degree of thrombophilia, comprising an antibody or a fragment thereof specifically binding to a von Willebrand factor-cleaving protease, are disclosed. The detection method and... Agent: Heslin Rothenberg Farley & Mesiti PC

20070275416 - Affinity marker for purification of proteins: The present invention relates to an affinity marker comprising a FLAG-domain, which contains at least one FLAG-tag, and a Streptavidin-binding domain (Strep-domain), which contains at least two Strep-tags, a protein containing this affinity marker, a nucleic acid which codes for it, a vector or a cell containing the affinity marker,... Agent: Clark & Elbing LLP

20070275423 - Methods, peptides and biosensors useful for detecting a broad spectrum of bacteria: Described herein are methods of detecting a wound infection and for detecting the presence or absence of bacteria, for example, wound bacteria in a sample, by contacting a sample with a peptide substrate derived from the modification of the reactive site loop (RSL) domain of the α1-proteinase inhibitor. In the... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070275425 - Device and method for analysis of a metabolic malady: A method for detecting a metabolic malady in a subject, the method including: (a) measuring a quantitative feature of a lipid body disposed within a leukocyte derived from the subject, and (b) comparing the measurement obtained in step (a) with a threshold value, wherein if the measurement is significantly different... Agent: Pearl Cohen Zedek Latzer, LLP

20070275424 - Diagnostic tests and methods for diagnosing inflammatory bowel disease: Methods are disclosed for diagnosing inflammatory bowel disease (IBD), one exemplar method of which includes determining whether a sample is positive for anti-flagellin antibodies (AFA), diagnosing the presence of IBD when the sample is positive for AFA, and diagnosing the absence of IBD when the sample is negative for AFA.... Agent: Christopher B Linder Thomas Kayden Horstemeyer & Risley

20070275426 - Disk-like microfluidic structure for generating diffrent concentration fluid mixtures: A disk-like microfluidic structure includes a disk, and a plurality of microfluidic systems formed on the disk and covered by a top sealing layer. Each microfluidic system includes a first and a second supply chamber located near a geometrical center of the disk, and at least one receiving chamber communicably... Agent: Rosenberg, Klein & Lee

20070275427 - Method of detecting allergen: The present invention provides an immunological detection method that can detect milk allergens, allergens of albumen, flour, buckwheat and peanut with high sensitivity in foods containing these allergens regardless they are denatured/native, and a detection kit to be used therefor. It is a method for detecting allergens by using 2... Agent: Venable LLP

20070275429 - Method for measuring high density lipoprotein cholesterol: An object to be attained by the present invention is to provide a method for conveniently, rapidly, and specifically measuring HDL-C in a specimen by use of inexpensive materials, and to provide a reagent kit for HDL-C detection and a dry analytical element for HDL-C detection. The present invention provides... Agent: Birch Stewart Kolasch & Birch

20070275430 - Determining the concentration of analytes in sample by direct mediation of enzymes: The glucose content of blood can be determined by contacting a blood sample with a test strip containing a glucose dehydrogenase dependent on PQQ (or derivatives or isomers) thereof as a co-factor, a tetrazolium salt indicator, but in the absence of a mediator.... Agent: Nixon Peabody, LLP

20070275431 - Detection of preterm labour: The invention describes a method for diagnosis of preterm labour in a mammal, comprising measuring levels of an endocannabinoid such as anandamide in a subject. Elevated levels are indicate of preterm labour. The measurement is typically performed during late pregnancy, such as the third trimester in humans. In certain embodiments,... Agent: Wolf Greenfield & Sacks, P.C.

20070275432 - Means for a quantitative detection of cytochrome c: The invention relate to a method for detecting cytochrome c in a given biological sample, comprising: adding to said sample an efficient amount of two redox couples allowing for a cycling oxido-reduction of cytochrome c, said couples comprising an oxidizing agent consisting of cytochrome c oxidase enzyme and a reducing... Agent: Buchanan, Ingersoll & Rooney PC

20070275434 - Apoptosis-based evaluation of chemosensitivity in cancer patients: Induction of apoptosis in target cells is a key mechanism by which chemotherapy induces cell killing. An in vitro system has been established for determining carboplatin and paclitaxel (Taxol) chemosensitivity of epithelial ovarian cancer cells, where measurements of caspase-3 activation are surrogate markers for activation of chemotherapy-induced programmed cell death.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070275435 - Cell culture chip and method for real-time monitoring of a cell culture using the same: Disclosed herein are a cell culture chip for monitoring a cell culture in real time and a method of monitoring the cell culture using the cell culture chip. The cell culture chip includes a cell culture chamber formed by side walls of a non-conductive material and a bottom layer of... Agent: Cantor Colburn, LLP

20070275433 - Cells containing a nanopatch sensor in their membrane: The present invention provides isolated cells comprising nanopatch sensors integrated into the cell membrane thereof, wherein said sensors are provided in the form of perturbation-sensitive constructs, and wherein said perturbation-sensitive constructs respond to perturbations of the cell membrane by means of a detectable change in one or more physical or... Agent: Nixon & Vanderhye, PC

20070275437 - Antibodies to g protein-coupled receptor: A novel gene (designated PHOR-1) that is highly over-expressed in prostate and other cancers and its encoded protein are described. PHOR-1 is a G protein-coupled receptor with homology to receptors involved in olfaction. PHOR-1 in normal human tissues is restricted to prostate, and this gene is highly over-expressed in prostate... Agent: Morrison & Foerster LLP

20070275438 - Compositions and methods for producing fermentation products and residuals: The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the... Agent: Wilson Sonsini Goodrich & Rosati

20070275439 - Methods to obtain recombinant proteins with increased sialylation from cells that express adenovirus e1a protein, and proteins obtained thereby: The invention provides compositions comprising one or more isoforms of an erythropoietin (EPO) comprising glycans linked thereto, characterized in that said glycans comprise LewisX structures and on average at least 6 sialic acid moieties per EPO molecule. The invention further provides methods for obtaining a composition comprising one or more... Agent: Trask Britt

20070275436 - Polyene polyketides, processes for their production and their use as a pharmaceutical: This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells.... Agent: Merchant & Gould PC

20070275440 - Regulation of transcription factor, nf-il6/lap: An alteration in phosphorylation of serine 105, within the actvation domain of NF-IL6/LAP, alters its transcriptional efficacy. Potypeptides, polynucleotides and methods of use for modified transcriptional activators allow regulation of gene expression.... Agent: Lisa A. Haile, J.d., Ph.d. Gray Cary Ware & Freidenrich LLP

20070275441 - Ocular tissue modification: The present invention relates generally to the field of tissue modification, and in particular, but not exclusively, to methods of modifying cells of ocular and particularly corneal tissue to produce immunoglobulins or immunoglobulin fragments. The invention also relates to modified ocular cells and tissues, to expression vectors utilised in such... Agent: Seed Intellectual Property Law Group PLLC

20070275442 - Side chain deuterated amino acids methods of use: Protein structural determination using NMR techniques is improved through use of proteins in which one or more amino acids in the peptidic sequence are isotopically enriched in the sidechain with 2H and are isotopically enriched on the backbone with 13C, 15N, 2H or any combination thereof. This invention provides amino... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070275443 - Random drift mutagenesis: A method for producing a mutant gene encoding a functional gene product comprising: (a) introducing one or more mutations into a gene to form a mutated gene; (b) providing the mutated gene to a host microorganism; (c) culturing the host microorganism containing the mutated gene under conditions which allow expression... Agent: Knobbe Martens Olson & Bear LLP

20070275444 - Thermostable omega-transaminases: Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereoselectively one of a pair of chiral amines in which the amino group is bound... Agent: Banner & Witcoff, Ltd.

20070275445 - Process for the production and recovery of hydrocarbons: The invention is directed to a process for the production and recovery of chemicals, in particular hydrocarbons, from a fermentation medium, wherein solvent impregnated carriers are used. Accordingly, the invention provides a process for the production of hydrocarbon from a fermentation liquid comprising: forming said hydrocarbon from said fermentation liquid... Agent: Hoffmann & Baron, LLP

20070275446 - Biomass conversion performance using igneous phyllosilicate minerals with high emission of far-infrared light: The present invention relates to applications of far-infrared-inducing natural minerals to improve biomass conversion performance by promoting the growth of microbes, especially in the fermentation process. The present invention further relates to the enhancement of other enzyme reactions during the fermentation process. The present invention is applicable for use in... Agent: Drinker Biddle & Reath LLP Attn: Patent Docket Dept.

20070275447 - Indirect or direct fermentation of biomass to fuel alcohol: A novel clostridia bacterial species (Clostridium carboxidivorans, ATCC BAA-624, “P7”) is provided. P7 is capable of synthesizing, from waste gases, products which are useful as biofuel. In particular, P7 can convert CO to ethanol. Thus, this novel bacterium can transform waste gases (e.g. syngas and refinery wastes) into useful products.... Agent: Fellers Snider Blankenship Bailey & Tippens

20070275448 - Methods for obtaining optically active epoxides and vicinal diols from meso-epoxides: The invention provides yeast strains, and polypeptides encoded by genes of such yeast strains, that have enantiospecific meso-epoxide hydrolase activity. The invention also features nucleic acid molecules encoding such polypeptides, vectors containing such nucleic acid molecules, and cells containing such vectors. Also embraced by the invention are methods for obtaining... Agent: Fish & Richardson P.C.

20070275449 - Method for large-scale production, isolation, purification and the uses of multi-type recombinant adeno-associated virus vectors: The present invention relates to the method for production, isolation, purification and the uses of recombinant herpes simplex virus vectors loaded with five sero-type adeno-associated virus AAV1, 3, 4, 5 and 6 respectively. The above five sero-type recombinant herpes simplex viruses are HSV-r2c1, HSR-r2c3, HSV-r2c4, HSV-r2c6 respectively. The 1, 3,... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070275451 - Devices and methods for the selective isolation of microorganisms: Devices and methods for isolating and/or culturing microorganisms are provided. The devices comprise one or more semi-permeable membranes and may additionally include a growth medium for the microorganism. The devices and methods described herein can be used to isolate and culture both known and novel microorganisms from any environment.... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070275450 - Method for stabilization of biological cultures to allow biological treatment of brines: A process is disclosed for the biological treatment under anaerobic/anoxic conditions for the degradation of pollutants present in brine solution used in waste water management, in industrial waste brine solutions and in waste oil field brine solutions, especially waste brine solutions contaminated with perchlorate and nitrate. A culture capable of... Agent: Robert W Strozier, P.l.l.c

20070275452 - Biological reaction method and bioreactor: In a bioreactor, a culture solution derived from a cultivation tank is separated into bacteria cells and filtrate by a bacteria cell filter. The filtrate is introduced from the bacteria cell filter into a micro-nano bubble generation tank where micro-nano-bubbles are mixed with the filtrate. The filtrate containing micro-nano-bubbles is... Agent: Nixon & Vanderhye, PC

20070275453 - Method for the modification of polyacrylonitrile fibres containing vinyl acetate as a comonomer and polyamide fibres, using a cutinase enzyme: This invention relates a new enzymatic process for the modification of the surface of synthetic fibres using a cutinase enzyme (3.1.1.74). The enzymatic action causes the hydrolysis of the polyacrylonitrile fibres containing vinyl acetate as a comonomer and polyamide fibres, improving their hydrophilic characteristics and dyeing properties.... Agent: Sughrue Mion, PLLC

20070275454 - Electroporator having an elongated hollow member: An electroporation apparatus comprising an elongated hollow member in order to provide a uniform electric field during electroporation, wherein specifically, electroporation is carried out by applying electric pulses through a couple of electrodes from both end parts of the elongated hollow member, after the hollow member is charged with fluid... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070275455 - Valved, microwell cell-culture device and method: A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states... Agent: Perkins Coie LLP

20070275456 - Diagnostic testing apparatus: An apparatus for use in an assay process includes a pre-incubation chamber (10) defining a plurality of wells (14) having a porous base (18). The pre-incubation chamber (10) is attachable to a housing (12) carrying a porous membrane (32) disposed above and touching a body of absorbent material (36). A... Agent: Bozicevic, Field & Francis LLP

20070275457 - Cell culture surface chemistries: A surface supporting growth of cells in culture, the surface prepare to provide hydrophilic moieties exposed thereon for enhancing the attachment of biological materials. The surface contains the hydrophilic moiety as part of an amphipathic molecule also having a hydrophobic region that is anchored or embedded within a polymer substrate,... Agent: Wood, Herron & Evans, LLP

20070275458 - Three dimensional-bio-mimicking active scaffolds: The invention provides a Cellulose acetate (CA) thin, porous membranes produced by electrospinning precursor polymer solutions in acetone at room temperature and a process for manufacturing the same. The invention also provides a Cellulose acetate (CA) thin, porous membranes produced by electrospinning precursor polymer solutions in acetone at room temperature... Agent: Dilworth & Barrese, LLP

20070275460 - Fc variants with optimized fc receptor binding properties: The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.... Agent: Morgan, Lewis & Bockius, LLP

20070275459 - Method for preparing cell concentrate and cell composition: It is an object of the present invention to provide: a method for preparing a cell concentrate which efficiently separates nucleated cells from unnecessary cells contained in a cell-containing solution by simple operations, thereby reducing the volume of a solution used for cryopreservation that contains the nucleated cells, when the... Agent: Greenblum & Bernstein, P.L.C

20070275461 - Artificial dermis and method of preparation:

20070275462 - Human prostate cancer cell factor(s) that induce stem cell commitment and osteogenesis: Human prostate cancer (CaP) cells secrete biological activities that recruit cells to differentiate into the osteoblast lineage. Conditioned medium (CM) produced by metastatic human CaP cells (DuCaP and VCaP) induced commitment and differentiation of mesenchymal stem cells (MSC) into osteoblasts. CaP-CM induces cellular condensation into tissue-like aggregates. In turn, these... Agent: Fulbright & Jaworski L.L.P.

20070275463 - Serum-free media for chondrocytes and methods of use thereof: The present invention provides defined serum-free cell culture media useful in culturing fibroblasts, especially articular chondrocytes, that avoids problems inherent in the use of serum-containing media. The defined media comprise platelet-derived growth factor (PDGF), and chemically defined lipids, or combinations of these compounds. In another aspect, the present invention also... Agent: Genzyme Corporation Legal Department

20070275464 - Chitin oligosaccharide elicitor-binding proteins: The present inventors isolated and purified elicitor-binding proteins in good yield by combining the development of a column that uses APEA derivatives, pre-columns to remove non-specifically adsorbing substances, and effective elution methods. Using the N-terminal and internal chain amino acid sequences of the obtained proteins, the present inventors successfully isolated... Agent: Medlen & Carroll, LLP

20070275465 - Double-stranded ribonucleic acid with increased effectiveness in an organism: The invention concerns a method for the targeted selection of a double-stranded ribonucleic acid (dsRNA) consisting of two single strands that exhibits increased effectiveness in inhibiting the expression of a target gene by means of RNA interference, whereby the sequences of the single strands of the dsRNA are selected in... Agent: Foley Hoag, LLP

20070275466 - Methods of modifying genes in eukaryotic cells: Methods of creating mutations in genomic exons by inserting introns into the genomic exons via homologous recombination. Also, methods are provided for introducing modifications into genomic exons by inserting introns into the genomic exons via homologous recombination such that a mature mRNA transcript produced from a genomic region of the... Agent: Regeneron Pharmaceuticals, Inc

20070269796 - Microscope apparatus and cell observation method: The invention provides a microscope apparatus, used for identifying the cell phases of a plurality of cells mounted on a stage, including an analysis/observation optical system used for acquiring an observed-image of the cells and a stimulus optical system used for applying an optical stimulus to prescribed cells. Using these... Agent: Frishauf, Holtz, Goodman & Chick, PC

20070269809 - Estimation method, human estrogen receptor alpha gene, genomic dna, and diagnostic marker: e

20070269829 - Instrument and method for nucleic acid isolation: A nucleic acid isolation apparatus and method enables nucleic acid isolation from a nucleic-acid-containing sample quickly with high nucleic acid yield and purity. A nucleic acid isolation instrument 11 is supported by a stand 41 via a rib 19 (A). A solution is loaded into a first container 15 via... Agent: Mcdermott Will & Emery LLP

20070269819 - Method and apparatus for concentrating and amplifying nucleic acid in single micro chamber: A method of sequentially performing concentration and amplification of nucleic acid in a single micro chamber includes: introducing a nucleic acid-containing sample and a solution including a kosmotropic salt to a micro chamber having a hydrophilic interior surface to concentrate the nucleic acid by binding the nucleic acid on the... Agent: Cantor Colburn, LLP

20070269810 - Methods and compositions for detecting serotypes of chlamydia trachomatis capable of causing lymphogranuloma venereum: Disclosed are methods and compositions for conducting assays of samples utilizing polymerase chain reactions (“PCRs”) in the detection of serotypes of Chlamydia trachomatis capable of causing lymphogranuloma venereum (“LGV”). These serotypes are in the L group of Chlamydia trachomatis, and include the L I, L II, and L III serotypes.... Agent: Medical Diagnostic Laboratories LLC

20070269833 - Galectin-glycosaminoglycan complex and method for controlling galectin activity: A galectin-glycosaminoglycan complex and a method for controlling galectin activity.... Agent: Sughrue-265550

20070269837 - Devices and methods for fluorescent inspection and/or removal of material in a sample: An apparatus is provided that includes a light-emitting component, a light-detecting component, a lock-in amplifier, a frequency generator that is operatively linked to the lock-in amplifier and the light-emitting component, a speaker capable of emitting an audio signal wherein the output audio signal varies depending on the detected fluorescence in... Agent: James Mcgreevy

20070269840 - In-situ equilibrium dialysis: A method for the determination of analytes in samples using a pre-precipitated antibody complex. The complex includes an anti-analyte antibody and a secondary binding molecule that results in the precipitation of the antibody. Labeled-analyte analog competes for binding sites on the complex with analyte in the sample. The presence or... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070269850 - Elastomeric device for cell seeding on the bottom of a filter: An article is provided herein for use in seeding cells on at least one filter extending across at least one well of an assay device. The article includes an elastomeric body having spaced-apart first and second surfaces, and at least one channel extending between, and through the first and second... Agent: David W. Highet Vp & ChiefIPCounsel Becton, Dickinson And Company

20070269852 - Method and apparatus for detecting airborne pathogens using quantum dots: A method has been invented to detect and identify airborne pathogens and their properties based on the affinity of water-soluble quantum dot bioconjugates. A plurality of different sized quantum dot bioconjugates, where each size is conjugated with a different functional biological material or biomaterial, are combined in solution to form... Agent: James J. Muys

20070269789 - Bioreactor for producing a tissue prosthesis, particularly a heart valve: The invention relates to a bioreactor for producing a tissue prosthesis, particularly a heart valve, comprising a reactor chamber for holding a fluid nutrient medium and a prosthesis support, a device for placing the prosthesis support in the area of the reaction chamber, and a drive device for generating a... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070269792 - Cross-linked collagen matrix for producing a skin equivalent: A whole skin model is made by a process for the production of a whole skin model comprising the steps of: (a) providing a poorly soluble collagen obtained from collagen-containing tissue; (b) forming a homogeneous aqueous suspension by mixing the collagen with an aqueous medium; (c) forming a first matrix... Agent: Paul & Paul

20070269791 - Method of preparing isolated cell-free skin, cell-free dermal matrix, method of producing the same and composite cultured skin with the use of the cell-free dermal matrix: An object of the present invention is to provide a method for producing an ADM suitable as a scaffold for a cultured skin, that is, a separation and decellularization method that enables various types of extracellular matrixes such as a basement membrane to be preserved, allows the epidermal layer to... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070269790 - Methods of generating stem cells and embryonic bodies carrying disease-causing mutations and methods of using same for studying genetic disorders: Stem cells, stem cell lines and differentiated cells, tissues and organs which carry disease-causing mutations are provided. There is also provided a method of identifying agents suitable for treating disorders associated with at least one disease-causing mutations such as myotonic dystrophy and van Waardenburg syndrome.... Agent: Martin D. Moynihan Prtsi, Inc.

20070269793 - Bioactive boxes for cellular cultures: The invention relates to bioactive boxes for cellular cultures comprising a bilayer which is arranged on the bottom of said boxes and provided with an internal primary layer made of hydroxypropylmethylcellulose, or polyvinyl alcohol (PVA) and an external bioactive layer made of carboxypropylmethylcellulose. Said invention also relates to the use... Agent: Young & Thompson

20070269795 - Method for detecting the viability of trichuris suis eggs: A method for detecting the viability of Trichuris suis eggs by simulating in vitro a passage of the eggs through the gastrointestinal passage of a swine with regard to chronological sequence and medium. The method involves subjecting the eggs in vitro first to gastric simulation in gastric medium and then... Agent: Norris, Mclaughlin & Marcus, Pa

20070269794 - Screening method and screening apparatus using micro-chamber array: A method and apparatus for screening a microorganism or protein having a useful function by using a micro-chamber array. Using the screening method and screening apparatus in accordance with the present invention, a target protein having an enzymatic activity or a microorganism producing such a protein is screened from a... Agent: Drinker Biddle & Reath (dc)

20070269798 - Epitope-captured antibody display: Reagents and methods for detecting target proteins in a sample are provided. The reagents include a replicable genetic package, a protein displayed on an exterior surface of the package that is expressed from a heterologous nucleic acid borne by the package, and one or more antibodies complexed with the expressed... Agent: Townsend And Townsend And Crew, LLP

20070269797 - Method for analysis of the phenotypic characteristics of the human immunodeficiency virus (hiv): The present invention relates to a method for analyzing the phenotypic characteristics shown by certain virus strains, particularly human immunodeficiency viruses, involving the construction of a recombinant virus obtained by homologous recombination. The present invention also relates a kit comprising the primers, vectors, cell hosts, products and reagents required to... Agent: Hunton & Williams LLP Intellectual Property Department

20070269826 - Angular-dependent metal-enhanced fluorescence: The present invention relates to detection of fluorescence, and more particularly, to the use of fluorescent moieties in proximity to metallic surfaces to change the spatial distribution of fluorescence in an angular dependent manner and detecting emissions at a determined optimal detection angle thereby increasing sensitivity of the detection.... Agent: Marianne Fuierer Moore & Van Allen PLLC

20070269818 - Carbohydrate arrays: Methods of detecting a carbohydrate binding compound in a sample by providing a high density oligonucleotide array including a plurality of probe sequences, hybridizing a plurality of carbohydrates that include an oligonucleotide that is complementary to a probe sequence to the high density oligonucleotide array, hybridizing a sample including a... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070269828 - Compositions and methods for viral resistance genes: The present invention further provides a method of evaluating yellow fever virus susceptibility in a subject, which comprises obtaining a nucleic acid containing at least a portion of OAS gene from the subject, and determining whether the nucleic acid comprises SNPs relating to the susceptibility of the subject to yellow... Agent: Troutman Sanders LLP

20070269804 - Computer system and methods for constructing biological classifiers and uses thereof: The present invention provides systems and method for constructing classifiers that distinguish between trait subgroups using molecular marker data from blood samples. The invention further encompasses the use of the classifiers and combinations of molecular markers identified by the classifiers in a wide variety of applications including: diagnosis; prognosis; prediction... Agent: Jones Day

20070269823 - Detection and quality control of regulatory t cells through dna-methylation analysis of the foxp3 gene: The present invention relates to a method, in particular an in vitro method for identifying FoxP3-positive regulatory T cells, preferably CD25+CD4+ regulatory T cells of a mammal, comprising analysing the methylation status of at least one CpG position in the gene foxp3 or an orthologous or paralogous gene thereof, and... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070269822 - Detection of contaminating dna via apmplification of sequences of less than 100 bp: The present invention provides methods, compositions and kits for amplifying, measuring, and/or detecting contaminating DNA (e.g., ruminant and non-ruminant) in samples by amplification and/or detection of a target DNA of less than 100 base pairs in the samples.... Agent: Townsend And Townsend And Crew, LLP

20070269800 - Diagnostic and therapeutic use of foap-13 polynucleotides and polypeptides for neurodegenerative diseases: The present invention discloses the dysregulation of foap-13 gene expression in specific brain regions of Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing or prognosticating Alzheimer's disease in a subject, or for determining whether a subject is at increased risk of developing Alzheimer's disease.... Agent: Venable LLP

20070269807 - Diagnostics and therapeutics for diseases associated with putative cysteine protease 1 (prs1): The invention provides a human PRSC1 which is associated with the cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer,... Agent: Banner & Witcoff, Ltd.

20070269803 - Fluorogenic nucleic acid probes including lna for methods to detect and/or quantify nucleic acid analytes: The present invention relates to novel methods for detecting or quantifying nucleic acid analytes through their interactions with a nucleic acid probe or a pair of nucleic acid probes, wherein the probe or the pair of probes is comprised of at least one monomeric LNA moiety and two or more... Agent: Sigma-aldrich Co.

20070269821 - Lateral flow devices: An analytical test for an analyte comprises (a) a base, having a reaction area and a visualization area, (b) a capture species, on the base in the visualization area, comprising nucleic acid, and (c) analysis chemistry reagents, on the base in the reaction area. The analysis chemistry reagents comprise (i)... Agent: Evan Law Group LLC

20070269825 - Method and kit for nucleic acid sequence detection: A method and kit for detecting the presence of a target sequence in a polynucleotide analyte contained in a sample are disclosed. In practicing the method, the sample is mixed with a target probe having a sequence capable of hybridizing with said target sequence, under conditions effective to form a... Agent: Youxiang Wang

20070269814 - Method of pathogen or chemical detection: A method of determining the presence and level of microorganisms and/or chemicals in samples taken from generally any non-laboratory substance or environment. The method preferably comprises one or a combination of the steps of (a) prescreening for threshold levels of targeted microorganisms and/or (b) confirming the presence of targeted microorganisms... Agent: Fellers Snider Blankenship Bailey & Tippens

20070269813 - Methods and arrays for identifying human microflora: The present invention relates to a human microflora identification array. In particular, the present invention involves methods for identifying microorganisms, assessing microflora, diagnosing disease, providing a prognosis, and determining the efficacy of treatment, using one or more nucleic acid molecules having a sequence of SEQ ID NO: 1-585. The method... Agent: Antoinette G. Giugliano, P.C.

20070269824 - Methods and systems for evaluating health risk factors by measurement of dna damage and dna repair: Disclosed are methods for measuring the effects of environmental, physiological, or lifestyle variables on DNA damage and DNA repair activity as well as the use of measurements of DNA damage and DNA repair activity to predict increased risk for disease. Embodiments of the methods involve the use of a combination... Agent: Kilpatrick Stockton LLP

20070269817 - Methods for genotyping: The present invention provides for methods for discriminating between alleles at polymorphic positions in a genome. In general the methods employ allele specific extension of oligonucleotides that are complementary to one of the alleles at the 3′ end of the oligonucleotide. The allele specific oligonucleotides are resistant to proof reading... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070269820 - Methods for the detection of nucleic acid encoding alpha-amylase: The present invention is drawn to methods and compositions for the detection and/or quantification of nucleic acid encoding α-amylase in a sample. Provided herein are novel primer and probe compositions for use in detecting the presence of α-amylase in an organism, particularly using quantitative PCR methods. Provided herein are novel... Agent: Alston & Bird LLP

20070269801 - Multiplexed methylation detection methods: The present invention is directed to sensitive and accurate multiplexed assays for target analyte detection and detection of methylation in nucleic acid samples.... Agent: Mcdermott, Will & Emery

20070269815 - Multitargeting interfering rnas having two active strands and methods for their design and use: Interfering RNA molecules are now designed and produced with specificity for multiple binding sequences present in distinct genetic contexts in one or more pre-selected target RNA molecules and are used to modulate expression of the target sequences. The multitargeting interfering RNA molecules have two strands that target multiple target sites... Agent: Philip S. Johnson Johnson & Johnson

20070269816 - Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance: The present invention is directed to the field of nucleic acid diagnostics and the identification of base variation in target nucleic acid sequences. More particularly, the present invention relates to the use of such genotypic characterization of a target population of HIV and the subsequent association, i.e., correlation, of this... Agent: Philip S. Johnson Johnson & Johnson

20070269799 - Nucleic acid amplification methods: The present invention relates to assays and kits for carrying out said assays for the rapid, automated detection of infectious pathogenic agents and normal and abnormal genes. The present invention further relates to methods for general amplification of genomic DNA and total mRNAs and for analyzing differential mRNA expression using... Agent: Steven B. Pokotilow, Esq. Stroock & Stroock & Lavan LLP

20070269805 - Ola-based methods for the detection of target nucleic avid sequences: Method for the detection of a target sequence comprising ligating two probes when annealed adjacent to the target sequence, hybridisation of a compound primer to the ligated probes and after elongation of the compound primer, amplifying the elongated compound primer from primers annealing to primer binding sites provided in the... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070269806 - Polynucleotide arrays: The invention provides a hairpin polynucleotide, having a loop and a stem region, characterised in that a sulfur-based nucleophile is attached to an internal nucleotide in the hairpin through a linker to enable binding to a solid support.... Agent: Klauber & Jackson

20070269827 - Predicting and diagnosing patients with autoimmune disease: The present invention provides methods for the prediction and diagnosis of autoimmune diseases including Systemic Lupus Erythematosus using a panel of single nucleotide polymorphisms (SNPs).... Agent: Fulbright & Jaworski L.L.P.

20070269802 - Ranbp2 as modifiers of the pten/igf pathway and methods of use: Human RANBP2 genes are identified as modulators of the PTEN/IGF pathway, and thus are therapeutic targets for disorders associated with defective PTEN/IGF function. Methods for identifying modulators of FEN/IGF, comprising screening for agents that modulate the activity of RANBP2 are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20070269811 - Superoxide dismutase (sod) gene and a method of identifying and cloning thereof: The present invention provides a superoxide dismutase gene from Potentilla atrosanguinea, a construct containing the gene coding for superoxide dismutase and transformed E.coli producing the SOD protein.... Agent: Edwards Angell Palmer & Dodge LLP

20070269812 - System for detecting protease: Disclosed is a system for detecting a protease inside a cell. In one embodiment, the system includes a chimeric protein that comprises as covalently linked components: 1) at least one optionally masked signal protein; 2) at least one protease-specific cleavage site; and 3) at least one detectable amino acid sequence.... Agent: Fish & Richardson PC

20070269808 - Wnt receptor compositions and methods: Wnt receptor compositions and methods of use are disclosed. In particular, methods using Wnt receptors, such as Dfz2, in screens for compounds which modulate the binding of a Wnt polypeptide to a Wnt receptor.... Agent: Ropes & Gray LLP Patent Docketing 39/41

20070269831 - Method for early detection of ovarian cancer: YKL-40 levels in serum and plasma samples provide as an indicator of both the presence of early stage ovarian cancer and of its aggressiveness. Thus testing for YKL-40 levels in patients at risk but not yet displaying symptoms associated with ovarian cancer, or in patients newly diagnosed with early stage... Agent: Marina Larson & Associates, LLC

20070269834 - Methods and compositions for development of drug screening procedures and diagnostic tools: This invention defines novel research and clinical laboratory methodology and compositions related thereto appropriate for use in (a) determining the presence of a neurodegenerative disease selected from the group limited solely to Charcot-Marie-Tooth disease, familial Alzheimer's disease, familial Parkinson's disease, Huntington's disease, spinal muscular atrophy, Friedreich'a ataxia, giant axon neuropathy,... Agent: Howard K. Shapiro, Ph.d.

20070269832 - Novel affinity labels: wherein L, A, X, and R′ have any of the values defined in the specification, or salts thereof, as well as compositions comprising such compounds or salts. The composition of the amino acid side-chain (R′) along with the amino acid or amino acid sequence (peptide) of the X component of... Agent: Schwegman, Lundberg & Woessner, P.A.

20070269830 - Process for the identification of new medical targets: The present invention relates to a process for the isolation and identification of pharmaceutically relevant target compounds (TC) from a sample, said sample being derived from a living organism, wherein said target compound(s) bind(s) to a compound of interest (COI) under physiological conditions, said compound of interest (COI) being associated... Agent: Clark & Elbing LLP

20070269835 - Reagent for determining laminin 5 antigen in biological sample and assay method: A method of determining a laminin 5 antigen in a biological sample, comprising the steps of bringing an antibody reactive to a laminin 5 γ2 chain N-terminal fragment into contact with the biological sample; measuring a reaction of the antibody; and determining an amount of the laminin 5 antigen based... Agent: Choate, Hall & Stewart LLP

20070269838 - Method for whole surrounding surface display of target proteins using bacterial exoporium: The present invention relates to a method for expressing a target protein on an exosporium forming the outermost surface of bacterial spores. More particularly, the present invention relates to a method for expressing a target protein on the surface of cells and spores using an exosporium as a matrix for... Agent: Intellectual Property / Technology Law

20070269839 - Preparation of spheres for diagnostic tests: The invention relates to surfactant-free reagent spheres useful for biological tests particularly those involving antigen/antibody reactions.... Agent: Klauber & Jackson

20070269836 - Methods and compositions for the diagnosis of venous thromboembolic disease: The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out venous thromboembolic disease, pulmonary embolism, and/or deep vein thrombosis, and for risk stratification in such... Agent: Foley & Lardner LLP

20070269841 - Determination of concentration of fk778 by competitive immunoassay: Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to... Agent: Robert Deberardine Abbott Laboratories

20070269842 - Assay for acetyltransferases and acetyltransferase substrates: Methods of identifying an acetyltransferase substrate in a sample are provided. Also provided are methods of localizing acetylation of an acetyltransferase substrate in a cell. Additionally, methods of labeling a protein substrate of an acetyltransferase are provided, as are methods of assaying an acetyltransferase in a sample. Methods of quantifying... Agent: Amster, Rothstein & Ebenstein LLP

20070269843 - Diagnostic assays that use mycobacteriophages: The present invention provides a method for a rapid and efficient mycobacteriophage-based diagnostic assay for the presence of microbacteria that have mycolic-acid structures in their outer membranes, such as mycobacteria, using betaine-like detergents.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070269844 - Novel assay for inositol phosphorylceramide synthase activity: Disclosed is a simple and reproducible method for assaying inositol phosphorylceramide synthase activity that employs a fluorescence resonance energy transfer pair for measuring enzyme activity. The invention also includes a novel method for identifying IPC synthase inhibitors.... Agent: Jonathan P. O'brien

20070269845 - Method of generating and isolating tumour cells: The invention provides a method of generating and isolating cells of a defined tumour phenotype being invasive and angiogenesis-independent (phenotype I), from a tumour sample, said method comprising the steps of culturing tumour cells of said tumour sample for up to nine days in order to establish multicellular spheroids, and... Agent: Seed Intellectual Property Law Group PLLC

20070269847 - Methods, pharmaceutical formulations and kits for identification of subjects at risk for cancer: Subjects at risk for developing cancer may be identified by obtaining samples of diagnostic cells from the subjects and determining a measure of cytotoxicity of the cells, the measure of cytotoxicity correlating negatively with the risk of developing cancer. The development of cancer may be prevented in subjects determined to... Agent: Alston & Bird LLP

20070269846 - Organic cation transporter preferentially expressed in hematopoietic cells and leukemias and uses thereof: A novel organic cation transporter (OCT) gene, OCT 6, and use thereof is described. The OCT6 gene is preferentially expressed in human hematopoietic tissues, including CD34+ cells and leukemia cells. Its narrow tissue distribution, substrate specificity, and close homology to other cell membrane transporters make OCT6 an attractive target for... Agent: Mcdermott Will & Emery LLP

20070269849 - Air sampling method, device and system for microbiological analysis: A method of using an air suction device is provided having a device equipped with a removable sampling head that is replaced between each sampling operation. Inside the head is a Petri dish containing a culture medium. Air is sucked through the head in order to impact on the culture... Agent: Young & Thompson

20070269848 - Liquid crystalline substrates for culturing cells: The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells.... Agent: Godfrey & Kahn, S.c.

20070269851 - Colorimetric substrates, colorimetric sensors, and methods of use: Described herein is a substrate comprising at least one colorimetric component attached to a peptide, as well as methods for detecting a modification of said substrate. Also described are methods of detecting the presence or absence of a protein, for example, a protein produced by a microorganism, by contacting a... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070269853 - Integrated device for diagnostic analyses, and relative method: An integrated device for diagnostic analyses used to verify the presence of bacteria in at least a biological sample mixed with a eugonic culture broth, in order to identify the type of bacteria, and to test a series of antibiotics, identifying those effective to determine the antibiotic therapy. The device... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20070269854 - Method and device for measuring an enzymatic activity in a body fluid: The invention concerns a method and a device for measuring an enzymatic activity in a body fluid. The method comprises the following steps: a) providing a support having a conductive surface whereon is immobilized a substrate specific of the enzymatic activity to be measured, the substrate comprising an electroactive residue;... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070269855 - Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthases and accessory proteins, and uses thereof: The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.... Agent: Townsend And Townsend And Crew, LLP

20070269856 - Viral purification methods: The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filtration and column chromatography. Viruses and... Agent: Fish & Richardson P.C.

20070269857 - A process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity: The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and... Agent: Fitzpatrick Cella Harper & Scinto

20070269858 - Combinatorial biology: The present invention provides a method for merging combinatorial biosynthesis with techniques of synthetic organic chemistry. In general, this method, combinatorial biology, involves 1) providing “starter units”, wherein the starter units are capable of being accepted by the modular biosynthetic enzymatic machinery, and have incorporated therein a “functional handle” capable... Agent: Choate, Hall & Stewart LLP

20070269864 - Designer proton-channel transgenic algae for photobiological hydrogen production: A designer proton-channel transgenic alga for photobiological hydrogen production that is specifically designed for production of molecular hydrogen (H2) through photosynthetic water splitting. The designer transgenic alga includes proton-conductive channels that are expressed to produce such uncoupler proteins in an amount sufficient to increase the algal H2 productivity. In one... Agent: Knox Patents

20070269862 - Installation of genomes or partial genomes into cells or cell-like systems: A method is provided for introducing a genome into a cell or cell-like system. The introduced genome may occur in nature, be manmade with or without automation, or may be a hybrid of naturally occurring and manmade materials. The genome is obtained outside of a cell with minimal damage. Materials... Agent: Carr & Ferrell LLP

20070269866 - Methods and compositions for producing vitamin k dependent proteins: The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells.... Agent: Myers Bigel Sibley & Sajovec

20070269860 - Modified sarcosine oxidases, genes and recombinant dnas thereof, and methods for preparing the same: (1) A modified sarcosine oxidase with improved stability in the acidic range compared to a wild-type sarcosine oxidase. (2) A sarcosine oxidase gene encoding a modified sarcosine oxidase of the following (a), (b), or (c): (a) protein composed of the amino acid sequence represented by SEQ ID NO: 1 (b)... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20070269859 - Plant sterol acyltransferases: The present invention is directed to le