Chemistry: molecular biology and microbiology inventions 10/07

20070248952 - Compositions and methods related to profiling a plurality of cells based on peptide binding: Methods and compositions are described for classifying cells and/or peptides that associate or bind with a particular characteristic pattern to a plurality of cells or cell lines. Aspects of the invention also include the use of peptide(s) having an appropriate binding characteristic to deliver a drug to a cell or... Agent: Fulbright & Jaworski L.L.P.

20070248970 - Compositions and methods for detecting keratoconus: The invention provides a method and assay kits for detecting keratoconus, including sub clinical keratoconus, in a specimen. The method comprises assaying a specimen of corneal epithelium for the presence of an expression product of the AQP5 gene. The invention further provides a novel gene, KC6, that exhibits cornea-specific expression,... Agent: Karen S. Canady Canady & Lortz LLP

20070248977 - Method and apparatus for supporting analysis of gene interaction network, and computer product: Detailed information of each analysis subject partial network is displayed on a left pane of a screen. The detailed information includes the number of nodes, the number of edges, and accumulative coverage of the analysis subject partial network for each disease. Based on the detailed information, a user can designate... Agent: Staas & Halsey LLP

20070248991 - Base carrier for detecting target substance, element for detecting target substance, method for detecting target substance using the element, and kit for detecting target substance: An element to be used for detecting a target substance by using a capturing body for target substance and using surface plasmon resonance has a structure in which the metal structure having a particular pattern is located on a spherical support. Thus configured element for detecting the target substance can... Agent: Fitzpatrick Cella Harper & Scinto

20070248989 - Method and kit for the early detection of impaired renal status: A method and kit for identifying the presence of an early biomarker of impaired renal status following a renal event in a mammalian subject. The method typically comprises (a) providing a body fluid sample obtained from a mammalian subject following a renal event; and (b) detecting in the provided sample... Agent: Hasse & Nesbitt LLC

20070248999 - Method for determining the concentration of vital epithelial tumor cells in a body fluid: A method for determining the concentration of vital epithelial tumor cells in a body fluid is disclosed. The method comprises obtaining from the body fluid of a test subject a test specimen, labeling the epithelial tumor cells contained in said test specimen, applying the test specimen to a support, where... Agent: Fish & Richardson P.C.

20070249007 - Method and apparatus for the management of diabetes: A biological chip device having a biologic materials component according to embodiments of the invention may provide the ability to sense levels of blood parameters (e.g., glucose, insulin, and glucagon levels) in a patient. In certain embodiments of the invention, a device may include therapeutic abilities in which a portion... Agent: Intellectual Property Group Fredrikson & Byron, P.A.

20070249019 - Purification processes for isolating purified vesicular stomatitis virus from cell culture: Novel purification processes for obtaining vesicular stomatitis virus (VSV) of improved purity from mammalian cell culture are described herein. More particularly, in certain embodiments, a process is described for purifying VSV from cell culture fluid of a mammalian cell culture infected with VSV, the process comprising: clarifying the cell culture... Agent: Howson And Howson/wyeth Cathy A. Kodroff

20070248942 - Method for selectively removing virus and leukocytes, removing material and removing apparatus: It is intended to provide a method whereby a virus and leukocytes can be simultaneously eliminated from virus-containing blood and platelets can be recovered at a high yield, and a material and an apparatus therefor. A water-soluble carrier having surface which is capable of capturing a virus and leukocytes in... Agent: Young & Thompson

20070248941 - Storage and maintenance of blood products including red blood cells and platelets: Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond current periods. Additionally, the materials so treated exhibit extended circulation... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070248946 - Catheter testing system and uses thereof: The present invention relates generally to devices and systems for detecting infection within catheters. In particular, the present invention provides catheter testing systems configured to sterilely collect a biological sample from the interior of a catheter for purposes of testing the biological sample (e.g., for the presence of fibrin, sepsis,... Agent: Medlen & Carroll, LLP

20070248943 - Displaying cellular analysis result data using a template: In accordance with the principles of the invention, methods, systems, and computer-readable mediums are provided for displaying cellular analysis result data including accessing cellular analysis result data; determining frequency information of a plurality of cell populations from the cellular analysis result data; associating frequency information of each of the plurality... Agent: Beckman Coulter, Inc.

20070248948 - Method of measuring residual cancer and predicting patient survival: Method of Measuring Residual Cancer and Predicting Patient Survival Disclosed is a method for determining survival and relapse of a patient undergoing therapy for a tumor by determining a residual cancer burden index based on the bidimensional diameters of a primary tumor bed of said tumor in a resection specimen,... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070248944 - Preventive and remedy for collagen or elastin metabolic disorder: The present invention relates to a prophylactic agent or a therapeutic agent for a disorder of collagen or elastin metabolism, which comprises a a substance possessing JNK inhibitory activity as an active ingredient.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070248947 - Reagents and methods for using human embryonic stem cells to evaluate toxicity of pharmaceutical compounds and other chemicals: The invention provides biomarker profiles of cellular metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human embryonic stem cells (hESC) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070248945 - Stem cells derived from uniparental embryos and methods of use thereof: Embryonic stem cells derived from uniparental embryos and methods of use thereof are disclosed.... Agent: Dann, Dorfman, Herrell & Skillman

20070248951 - Determination method and determination kit: Disclosed herein are a determination method capable of determining the presence or absence of an anti-HIV antibody in a sample with accuracy even if an operation of cleaning is omitted and a determination kit to be used for the determination method. The determination method is as follows. First, a liquid... Agent: Greenblum & Bernstein, P.L.C

20070248953 - Pressure transduced chemical assay and method: An assay system has a chamber that receives a test strip onto which a sample comprising an analyte has been placed. The chamber is in gaseous communication with a piezoelectric material that generates an electrical signal in response to a pressure change in the chamber that is caused by a... Agent: Fish & Associates, PC Robert D. Fish

20070248949 - Sensitive and specific test to detect sars coronavirus: The invention provides a simple, specific and sensitive test for the presence of SARS coronavirus. Kits comprising primers useful in the test are also provided.... Agent: Birch Stewart Kolasch & Birch

20070248950 - Supported polydiacetylene 3-d arrays for flourescent or phosphorescent detection: Supported three-dimensional arrays of a polydiacetylene backbone bonded to and supported by a solid support in a sample are provided. The bonding is achieved by providing a support having thiol and/or amine groups and epoxy groups and/or maleimide groups, and a polydiacetylene backbone containing the other of thiol and/or amine... Agent: Connolly Bove Lodge & Hutz LLP

20070248963 - method for identifying pre-neoplastic and/or neoplastic states in mammals: The present invention relates to methods of identifying pre-neoplastic and/or neoplastic states in mammals and in particular to a method for identifying pre-neoplastic and neoplastic cells in tissues and body fluids, based on differential expression of purinergic receptors in these cells.... Agent: Ivor R. Elrifi, Esq. Mintz, Levin, Cohn, Ferris, Glovsky And

20070248960 - Arrays containing cleavable rnai molecules: A nucleic acid array is provided, as well as methods of using the same. In certain embodiments, the nucleic acid array comprises: a) a substrate; and b) an array of features on a surface of the substrate, where the features comprise interfering RNA molecules that are linked to the surface... Agent: Agilent Technologies Inc.

20070248982 - Automatic threshold setting and baseline determination for real-time pcr: The invention discloses a system and methods for quantitating the presence of nucleic acid sequences by evaluation of amplification data generated using real-time PCR. In one aspect, the methods may be adapted to identify a threshold and threshold cycle for one or more reactions based upon evaluation of exponential and... Agent: Kilyk & Bowersox, P.l.l.c.

20070248962 - Compositions and methods for human metapneumovirus monoclonal antibodies: The present invention discloses specific human metapneumovirus monoclonal antibodies. The antibody is at least two-fold less reactive with non-human metapneumoviruses including, but not limited to, respiratory viruses or avian metapneumoviruses. Further, the antibody is at least two-fold more reactive with a human metapneumovirus (i.e., for example, Type A or Type... Agent: Medlen & Carroll, LLP

20070248965 - Compositions and methods for the detection of a nucleic acid using circular probes in a cleavage reaction: The invention provides a method of generating a signal indicative of the presence of a target nucleic acid sequence in a sample by forming a cleavage structure by incubating a sample comprising a target nucleic acid sequence with a probe, nucleic acid polymerase, nuclease and optionally a primer. The target... Agent: Agilent Techologies Inc

20070248969 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent: Casimir Jones, S.c.

20070248957 - Encoded solid supports for biological processing and assays using same: Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20070248959 - Genetic markers for obesity: The present invention is directed to new genetic variants or polymorphisms at the perilipin locus (PLIN) including PLIN1: 6209T (allele 1)>C (allele 2); PLIN3 10171 (allele 1) A>T (allele 2); PLIN4: 11482G (allele 1)>A (allele 2); PLIN5: 13041A (allele 1)>G (allele 2) and PLIN6: 14995A (allele 1)>T (allele 2), and... Agent: David S. Resnick

20070248974 - Identification of a novel gene underlying familial spastic paraplegia: Methods of identifying polymorphisms associated with hereditary spastic paraplegia (SPG), are described. The polymorphisms associated with SPG include specific mutations in the receptor expression enhancing protein 1 (REEP1) gene. Also described are methods of diagnosis of SPG.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070248976 - Inverted orientation for a microplate: A method of conducting amplification comprising loading a liquid polynucleotide sample into a well of a microplate and covering the well of the microplate with a cover, such that the cover fluidly seals the liquid polynucleotide sample within the well. The method then comprises inverting the microplate such that the... Agent: Harness, Dickey & Pierce, P.L.C

20070248964 - Method and device for detection of nucleic acids and/or polypetides: A method for the detection and/or quantification of at least one target nucleic acid or target polypeptide in a sample of nucleic acids or polypeptides comprising the steps of: a) providing a sample comprising nucleic acids or polypeptides; b) labeling the nucleic acids or polypeptides with a ligand conjugate, the... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20070248956 - Methods and compositions for autism risk assessment: Methods and compositions are provided for evaluating an individual for relative genetic risk for autism, for identifying a form of a genetic polymorphism that is linked to autism, and for evaluating whether a compound affects autism.... Agent: Amster, Rothstein & Ebenstein LLP

20070248961 - Methods for detecting mutations in jak2 nucleic acid: The present invention relates to methods for detecting JAK2 nucleic acid in acellular bodily fluid samples from patients with neoplastic disease and determining if the nucleic acid contains one or more mutations or one mutation and one deletion. The methods are useful for diagnosing patients that have cells with mutations... Agent: Foley & Lardner LLP

20070248975 - Methods for monitoring the expression of alternatively spliced genes: Methods, probe arrays and computer software products are provided for determining the arrangement of sequence elements. In one embodiment, methods for making and using exon chips are provided. The exon chips may be used to identify and quantify splice variants.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070248979 - Methods of enriching for and identifying polymorphisms: The invention encompasses methods for enriching for and identifying a polymorphism within a nucleic acid sample either by separating a subset of a nucleic acid sample or by selectively replicating a subset of a nucleic acid sample such that the polymorphism is contained within a nucleic acid population with reduced... Agent: Agilent Techologies Inc

20070248980 - Methods of enriching for and identifying polymorphisms: The invention encompasses methods for enriching for and identifying a polymorphism within a nucleic acid sample either by separating a subset of a nucleic acid sample or by selectively replicating a subset of a nucleic acid sample such that the polymorphism is contained within a nucleic acid population with reduced... Agent: Agilent Techologies Inc

20070248958 - Microfluidic devices: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.... Agent: Wilson Sonsini Goodrich & Rosati

20070248972 - Page-4, an x-linked gage-like gene expressed in normal and neoplastic prostate, testis and uterus, and uses therefor: PAGE-4 is a gene preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus and placenta, as well as in prostate cancer, testicular cancer and uterine cancer. This expression pattern makes it a target for diagnosis and for vaccine based therapy of neoplasms of prostate, testis... Agent: Klarquist Sparkman, LLP

20070248966 - Parallel high throughput single molecule sequencing process: The invention relates to a process and to an apparatus for parallel high throughput sequencing of nucleic acid molecules, in particular in the single molecule format. The present invention further relates to a process and an apparatus for a parallel high throughput study of enzyme-substrate interactions, in particular in the... Agent: Fulbright & Jaworski, LLP

20070248981 - Predicting mortality and detecting severe disease: Measurement of circulating ST2 and/or IL-33 concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, and the detection of severe disease.... Agent: Fish & Richardson PC

20070248954 - Primers for use in detecting beta-lactamases: Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain β-lactamase genes. The primers can be employed in methods to identify nucleic acid characteristic of family-specific (and even group-specific) β-lactamase enzymes in samples, and particularly, in clinical isolates of Gram-negative bacteria.... Agent: Mueting, Raasch & Gebhardt, P.A.

20070248968 - Probe of human papillomavirus and dna chip comprising the same: Oligonucleotide probes for analyzing 40 types of HPV were synthesized, and DNA chips were produced by using the oligonucleotide probes. The synthesis of the oligonucleotide probes is based on clones of L1 and E6/E7 genes of 35 types of HPV obtained from cervical cell specimens from 4,898 Korean adult women... Agent: Osha Liang L.L.P.

20070248971 - Programming microfluidic devices with molecular information: The invention provides a microfluidic device having a plurality of chambers each containing separately deposited reagents. The invention also provides an efficient PCR-based method for producing a linear expression template. The invention also provides methods for analyzing interactions between molecules, involving flow-deposition of expression templates on the substrate of chambers... Agent: Townsend And Townsend And Crew, LLP

20070248967 - Reporter assay using secrectory luminescent enzymes: It is an objective of the present invention to provide a method for convenient and highly sensitive reporter assay. A secretory luminescent enzyme is used as a reporter protein so as to evaluate the expression, functions, transcriptional activity, or transcriptional control functions of a foreign gene or a foreign DNA... Agent: Sughrue Mion, PLLC

20070248978 - Steroid responsive nucleic acid expression and prediction of disease activity: The invention relates to methods useful for diagnosing and monitoring the steroid responsiveness of a subject by detecting expression of steroid modulated genes and for predicting transplant rejection and non-rejection.... Agent: Morrison & Foerster LLP

20070248973 - Terminating substrates for dna polymerases: This invention concerns novel terminating substrates for DNA polymerases. The substrates are nucleoside triphosphates labeled with lanthanide chelates.... Agent: Buchanan, Ingersoll & Rooney PC

20070248955 - Use of genetic polymorphisms to predict drug-induced hepatotoxicity: IL1A or a gene located near IL1A on chromosome 2q14 may contribute to hepatotoxicity, as measured by increased serum levels of aspartate transaminase, during N-benzoyl-staurosporine treatment for macular edema. Accordingly, genetic polymorphisms in the IL1A gene are useful as biomarkers for predicting staurosporine derivative-mediated hepatotoxicity.... Agent: Novartis Corporate Intellectual Property

20070248988 - Binding molecules and methods of use thereof: Binding molecules are described.... Agent: Lahive & Cockfield, LLP

20070248983 - Device and method for simultaneously identifying blood group antigens: The invention relates to a device for simultaneously, qualitatively or quantitatively identifying a number of analytes in a liquid sample. The device comprises a membrane with: a charging zone for applying the liquid sample; at least two indicator zones, which can interact with the analytes, and at least one absorption... Agent: Ratnerprestia

20070248985 - Functional porous substrates for attaching biomolecules: A substrate comprising a microporous microstructure, an interlayer over at least a portion of the microstructure and a functional layer attached to the interlayer, the functional layer having functional sites with a density of at least 50 nanomoles/cm2.... Agent: Allan M. Weatcraft W.l. Gore & Associates, Inc.

20070248990 - Method for stabilizing functional groups on a surface of a polymer used as solid support for making microarrays: The present invention concerns a new and simplified method for obtaining a polymer surface activated with a high density of aldehyde functions which are stable with time and ready to react covalently with amino groups present on a great number of different molecules used as capture probes according to a... Agent: Knobbe Martens Olson & Bear LLP

20070248992 - Method for the determination of the composition of textile fibers: Method for the recognition and the quantitative evaluation of mixed textile fibers of animal source, comprising the steps of: preparing and conditioning of the fibers to be analysed; extracting of the proteins by means of demolition of the fibers, and subsequent centrifugation; dosing the mixture of proteins contained in the... Agent: Matthias Scholl

20070248984 - Methods and compositions for separating cells: The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover rare cell types in high yield.... Agent: Fish & Richardson P.C.

20070248994 - Sensor constructs and detection methods: Sensor constructs for detecting the presence of an analyte in a sample comprising a molecular scaffold, a pair of labels which interact via Förster resonance energy transfer, and at least one molecular recognition domain for binding the analyte. A changed optical signal is produced when the analyte is bound by... Agent: Sheldon Mak Rose & Anderson PC

20070248986 - Systems and methods for predicting an individual's risk of developing rheumatoid arthritis: Methods for predicting the likelihood of development of rheumatoid arthritis for individuals that present with recent-onset undifferentiated arthritis. The methods are based on the determination of a set of clinical parameter values and determining a predicted risk for developing rheumatoid arthritis by correlating the parameter values with predefined risk values... Agent: Knobbe Martens Olson & Bear LLP

20070248987 - Target substance detection material and method and kit for detecting target substance: In the present invention, a target substance detection material, which includes a metal structure, a target substance capturing unit, and a polymer matrix retaining the metal structure and the target substance capturing unit, captures a target substance, and as a result, the volume of the polymer matrix is changed. Such... Agent: Fitzpatrick Cella Harper & Scinto

20070248993 - Un-supported polymeric film with embedded microbeads: The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) films and organic (polymeric)—microparticle composite films of tailored composition and morphology; the present invention further relates to the incorporation... Agent: Eric P. Mirabez

20070248998 - Integrin cd18 is a novel stromal stem cell marker and functions to promote osteogenesis: The present invention is directed to a new bone marrow stromal stem cell (BMSSC) marker, CD18, for use in selecting a population of cells enriched in BMSSCs, from bone marrow cells, adipose cells, or peripheral blood. The invention is further directed to methods for selecting a population of cells enriched... Agent: Evans & Molinelli, PLLC

20070249000 - Method for diagnosing a person having b-cell pathologies: Described is a method for diagnosing a person having or being at risk of developing certain B-cell pathologies, including Sjögren's Syndrome and non-Hodgkin's lymphoma, and excluding patients with symptoms similar to Sjögren's Syndrome but with a different etiology, comprising the following steps: providing a sample of a body fluid or... Agent: Large Scale Biology Corporation

20070249001 - Multiplex detection compositions, methods, and kits: The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention also relates to methods for determining the presence of at least one analyte in... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070248997 - Method of using one-dimensional and multi-dimensional nuclear magnetic resonance to identify compounds that interact with target biomolecules: The invention provides a method using one-dimensional and multi-dimensional NMR spectroscopy for identifying ligands to target biomolecules.... Agent: Glaxosmithkline Corporate Intellectual Property - Uw2220

20070248996 - Modulators of beta-amyloid peptide aggregation comprising d-amino acids: Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected... Agent: Lahive & Cockfield, LLP

20070248995 - Molecules: This invention relates to the gene encoding gerbil neurokinin 1 receptor (gNK1r) and to proteins encoded by the gene, as well as to means of regulating their biological activity. In addition the invention relates to the use of the gene and protein to identify therapeutic agents for controlling asthma, pain,... Agent: White & Case LLP Patent Department

20070249005 - Gastrin hormone immunoassays: The invention provides assay methods for the detection and quantitation of gastrin hormones, including total and free gastrin hormone in a sample. ELISA-type heterogeneous phase assays suitable for use with biological fluid samples such as blood, plasma or other bodily fluids of a mammal, particularly a human subject are provided.... Agent: Fish & Richardson, PC

20070249004 - Gsk3 polypeptides: The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of... Agent: Novartis Vaccines And Diagnostics Inc.

20070249003 - Methods and devices for diagnosis of appendicitis: A method is provided for determining the severity of appendicitis in a patient that includes testing a blood, serum or plasma sample from the patient for the quantity of MRP8/14 in the sample and comparing it with the quantity of MRP8/14 present in standard samples correlated with an appendicitis severity... Agent: Greenlee Winner And Sullivan P C

20070249002 - Systems and methods for characterizing kidney diseases: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the... Agent: Medlen & Carroll, LLP

20070249006 - Assays, antibodies, and standards for detection of oxidized and mda-modified low density lipoproteins: Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the assays, and a storage-stable standard (which may be used as a calibrator and/or control) are disclosed. MDA-modified LDL and OxLDL are implicated in atherosclerosis... Agent: Stephen P. Gilbert, Esq. Bryan Cave LLP

20070249008 - Cardiovascular prognostic and diagnostic marker: The present invention relates to a method for determining an increased risk of mortality or of a cardiac and/or vascular event in a patient, comprising: determining the sPLA2 activity of said patient, comparing said activity to a predetermined value, a higher sPLA2 activity of said patient as compared to said... Agent: Young & Thompson

20070249009 - Compositions and methods for altering rnai: The present invention relates to compositions and methods for altering (e.g., enhancing) RNAi. In particular, the present invention provides systems and methods for identifying regulators of RNAi. For example, the present invention provides RNAi regulators (e.g., HPS1 and HPS4) and methods of altering (e.g., inhibiting) these regulators in order to... Agent: Medlen & Carroll, LLP

20070249010 - Methods for treating glaucoma and macular degeneration: Inhibition of geranylgeranylation of Rho GTPases and heterotrimeric G-proteins in the aqueous outflow pathway increases aqueous humor outflow, possibly through the tissue relaxation, and through altered cell adhesive interactions and actin cytoskeletal organization in cells of the outflow pathway. In addition, such inhibition is useful for treating age-related macular degeneration.... Agent: Banner & Witcoff, Ltd.

20070249011 - Method for screening fungus-specific antimicrobial agent and kit therefor: An object of the present invention is to provide a method for effectively screening a agricultural chemical candidate or drug candidate. Specifically, an object of the present invention as to a agricultural chemical is to effectively screen, without the use of plants, a agricultural chemical candidate compound that does not... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070249013 - Collections of traceable compounds and uses thereof: The invention concerns the use of a collection of traceable cationic compounds for determining ligands of a receptor whose ligand is unknown or whose ligand useful for specific affinity binding studies is unknown, said traceable cationic compounds being characterized in that they comprise at least one basic amino acid residue... Agent: Young & Thompson

20070249012 - Microbial detection and quantification: Solvatochromic dyes are used herein to indicate the presence of bacteria by incorporating them into various substrates such as films, woven and nonwoven fabrics, paper towels, coform and airlaid materials and bonded carded webs. These dyes change color in response to a change in polarity of the environment. Since water... Agent: Kimberly-clark Worldwide, Inc. Catherine E. Wolf

20070249014 - Labeling and detection of post translationally modified proteins: Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling a biomolecules with an azide group.... Agent: Invitrogen Corporation C/o Intellevate

20070249015 - Method of isolation and purification of trypsin from pronase protease and use thereof: The present invention provides methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease mixture in a single affinity chromatography step and uses of the purified SGT.... Agent: Baxter Healthcare Corporation

20070249016 - Method for gene amplification: The present invention provides a double-stranded DNA constructed specially for gene amplification at high speed, a method for gene amplification using the double-stranded DNA and a method to produce proteins. A system to induce artificial gene amplification at high speed was constructed based on the mechanism of gene replication in... Agent: Drinker Biddle & Reath (dc)

20070249017 - Polynucleotides encoding polypeptides involved in amino acid biosynthesis in methylophilus methylotrophus: The present invention provides polypeptides and polynucleotides involved in amino acid biosynthesis in Methylophilus methylotrophus and methods of producing amino acids in microorganisms having enhanced or attenuated expression of these polypeptides and/or polynucleotides.... Agent: Cermak & Kenealy LLP Acs LLC

20070249018 - Reduced overflow metabolism and methods of use: The present invention provides modified bacterial cells and methods for using them. A modified bacterial cell can exhibit increased NADH oxidase activity, decreased ArcA activity, or the combination thereof. The methods include culturing a modified bacterial cell in aerobic conditions. The modified bacterial cell can produce less acetate during the... Agent: Mueting, Raasch & Gebhardt, P.A.

20070249020 - Cytokine zcytor17 ligand polypeptides and polynucleotides: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing... Agent: Zymogenetics, Inc. Intellectual Property Department

20070249021 - Deglycosylated and desialidated long pentraxin ptx3: Deglycosylated long pentraxin PTX3 and desialidated long pentraxin PTX3 are disclosed, as well as processes for their preparation, pharmacological compositions containing them, and their use for the preparation of a medicament for the treatment of diseases in which the use of the long pentraxin PTX is indicated, particularly infectious and... Agent: Lucas & Mercanti, LLP

20070249022 - Activin-actriia antagonists and uses for promoting bone growth: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070249023 - Process for immobilizing cells on a resin: A process for immobilizing cells is described, particularly procaryotic cells, which includes a step of adsorbing said cells on a resin, wherein such a resin is a weak anionic exchange resin and preferably has amino moieties; when the immobilized cells are UPase and/or PNPase producing cells, nucleosides can be produced... Agent: Akerman Senterfitt

20070249024 - Novel dna synthesis technology with 3'-beaded oligo dna and dna polymerase: A method of synthesizing a desired DNA having a predetermined sequence, comprising the steps of (a) preparing, based on the desired DNA, a plurality of 3′-biotin-immobilized oligo DNA having a fixed length; (b) preparing a starting DNA which has a complementary sequence to a 3′ end of a first immobilized... Agent: Omori & Yaguchi Usa, LLC

20070249025 - Enzymatic resolution of selective estrogen receptor modulators: The present invention relates to a process for preparing 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen-2-ol compounds useful as an estrogen agonist.... Agent: Pfizer Inc.

20070249026 - Delta 17 desaturases and their use in making polyunsaturated fatty acids: The present invention relates to Δ17 desaturases, which have the ability to convert ω-6 fatty acids into their ω-3 counterparts (i.e., conversion of arachidonic acid [20:4, ARA] to eicosapentaenoic acid [20:5, EPA]). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ17 desaturases along with a method of... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070249028 - Aerobic succinate production in bacteria: Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid.... Agent: Baker & Mckenzie LLP

20070249027 - Process for producing poly-beta-hydroxybutyrate: A process for producing poly-β-hydroxybutyrate (PHB) involves contacting maple sap with bacteria (e.g Alcaligenes latus) that convert sugars into poly-β-hydroxybutyrate. The use of maple sap is comparable to or better than the use of pure sucrose, and the use of maple sap results in PHB having higher weight average molecular... Agent: National Research Council Of Canada 1200 Montreal Road

20070249030 - Methods, apparatus, products and compositions useful for processing fermentation waste streams: A method for processing a stream from a fermentation process, wherein the stream comprises polysaccharides, the method comprising, contacting the stream with an enzyme to convert at least a portion of the polysaccharides into a fermentable sugar to form a fermentable sugar stream.... Agent: Gilbreth & Associates, P.C.

20070249029 - Self-sustaining and continuous system and method of anaerobically digesting ethanol stillage: A system and method of anaerobically digesting ethanol stillage and reintegrating substantially all by-products thereof back into the system is disclosed. The system includes an ethanol producing facility for producing ethanol and an anaerobic digestion facility for anaerobically digesting stillage from the ethanol producing facility to produce a plurality of... Agent: Antony C. Edwards

20070249031 - Aminopyrimidines useful as kinase inhibitors: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.... Agent: Covington & Burling, LLP Attn: Patent Docketing

20070249032 - Flavivirus vaccine: Replicon virus-like particles can be used as flavivirus vaccines.... Agent: Bell, Boyd, & Lloyd LLP

20070249033 - Methods of terminal sterilization of biological products: The invention relates to methods of sterilizing biologically active products, particularly therapeutic or prophylactic products and the compositions obtained thereby. The methods include obtaining a dried sample containing an amount of trehalose sufficient to render heat stability to the product and exposing the dried sample to heating conditions at a... Agent: Morrison & Foerster LLP

20070249034 - Surfactant biocatalyst for remediation of recalcitrant organics and heavy metals: Novel strains of isolated and purified bacteria have been identified which have the ability to degrade petroleum hydrocarbons including a variety of PAHs. Several isolates also exhibit the ability to produce a biosurfactant. The combination of the biosurfactant-producing ability along with the ability to degrade PAHs enhances the efficiency with... Agent: J. Bennett Mullinax, LLC

20070249035 - Surfactant biocatalyst for remediation of recalcitrant organics and heavy metals: Novel strains of isolated and purified bacteria have been identified which have the ability to degrade petroleum hydrocarbons including a variety of PAHs. Several isolates also exhibit the ability to produce a biosurfactant. The combination of the biosurfactant-producing ability along with the ability to degrade PAHs enhances the efficiency with... Agent: J. Bennett Mullinax, LLC

20070249036 - Apparatus for high-throughput electroporation: An electroporator for high-throughput electroporation is constructed with a well plate in which each well has internal electrodes that extend beyond the opening of the well to form contact areas, either as horizontal platforms extending laterally from the well rims or as extended heights of thin electrode plates. The electroporator... Agent: Townsend And Townsend And Crew, LLP

20070249038 - Microfluidic device for single cell targeted operations: Here we describe an integrated microfluidic chip for delivery of fluids inside or in proximity of individual cells or for measurement of physical quantities. In this device, a cell suspension is pumped through a microchannel in which cells are lined up, pushed on a static microneedle or micropipette, and then... Agent: Andrea Adamo

20070249037 - Monitoring of vitamin k nutritional status: Disclosed herein is a diagnostic apparatus for determining the level of certain nutrients in a body fluid sample, which are used by clinicians to assess proper dosages of anticoagulants, such as coumarin. Specifically exemplified is a diagnostic apparatus that determines a patient's vitamin K nutritional status by determining the level... Agent: Beusse Wolter Sanks Mora & Maire

20070249039 - Minute creature detection system and analytic chip: It is an object of the present invention to shorten the operation time from sampling through to genetic test, and enable the detection of a minute creature with good accuracy. Provided is minute creature detection system in which treatments from gene extraction to detection of are conducted on an analytic... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070249040 - Simple portable bacteria detector: A portable bacteria detector not only simply capable of inspecting the presence of food-poisoning bacteria and the like but also provided with a disinfecting or sterilizing means itself has been widely used. As its application fields spread, the detector has been required to be more inexpensive and be constituted in... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070249041 - Cell co-culture apparatus for researching cell interaction and method thereof: A cell co-culture apparatus and a method of co-culturing and isolating cells using the cell co-culture apparatus to research interactions between cells by direct contact between the cells are provided. The cell co-culture apparatus includes a first substrate including a substrate portion and a plurality of projections provided on a... Agent: Cantor Colburn, LLP

20070249043 - Adenoviral expression vectors: The present invention provides a recombinant adenovirus vector characterized by the partial or total deletion of adenoviral E2B function and having an expression cassette containing a heterologous sequence encoding a protein of interest inserted into the E1 region. Such vectors are designed to reduce or eliminate the occurrence of replication... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070249042 - Strains of e. coli for plasmid dna production: A general method and strains of bacteria are described, by means of which it is possible to dramatically purify plasmid DNA with respect to genomic DNA, and RNA. In one preferred embodiment, lysis and nuclease removal of host nucleic acids is an integral component of the fermentation/harvest process, and as... Agent: Brooks Kushman P.C.

20070249045 - Adipose derived adult stem cells in hepatic regeneration: The present invention provides a method to derive hepatic stem cells from stem cells derived from non-liver tissue. In one embodiment of the invention, hepatic stem cells are derived from adipose stem cells. The invention also provides a method of enhancing hepatic cytokine production (e.g., HGF) from ASCs, which may... Agent: Foley And Lardner LLP Suite 500

20070249044 - Microstructures in three dimensional gel suspensions for growth of cells: The present invention provides a three-dimensional cell culture system for the growth of cells and the method of making the same.... Agent: Marshall, Gerstein & Borun LLP

20070249046 - Apparatus and method for the static application of therapeutic ultrasound and stem cell therapy of living tissues: Devices and methods for treating tissue injuries and augmenting the maturation and differentiation of stem cell populations are provided. The devices comprises ultrasonic oscillators capable of variable frequency output, user-selectable based on the tissue being treated. The devices produce therapeutic ultrasound that is pulsed and has a modulated amplitude and... Agent: Seed Intellectual Property Law Group PLLC

20070249047 - Differentiation of multi-lineage progenitor cells to respiratory epithelial cells: Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described, as well as methods of differentiating the progenitor cells into type II alveolar cells.... Agent: Fish & Richardson P.C.

20070249049 - 6-modified bicyclic nucleic acid analogs: The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.... Agent: Schwegman, Lundberg & Woessner/isis

20070249050 - Substituted aromatic compounds for inflammation and immune-related uses: e

20070249048 - Triptolide 5,6-derivatives as immunomodulators and anticancer agents: Compounds useful as immunosuppressive, anti-inflammatory and anticancer agents and methods of their preparation and use are described. The compounds are analogs or derivatives of triptolide and related compounds, modified at the 5- and/or 6-position relative to the naturally occurring compounds.... Agent: Perkins Coie LLP

20070249051 - Vinyl-phenyl derivatives for inflammation and immune-related uses: m

20070249052 - Cartilage regeneration by generation of chondrons under high concentrations of magnesium: The present invention relates to a method for the generation of chondrons and of cartilaginous tissue. In particular, the present invention relates to the ability of Mg ions to stimulate the growth and regeneration of chondrons, particularly of pseudo-chondrons as an intermediate in the regeneration and growth of cartilaginous tissue.... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070243522 - Inspection chip for biological material: There is provided an inspection chip capable of performing a number of solution feeding processes promptly and accurately. The inspection chip has one continuous flow path comprising a reaction flow path for accommodating a plurality of beads with immobilized probes of types different each other, a first and second solution... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070243521 - Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy: A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to... Agent: William H. Eilberg

20070243550 - Molecular detection and quantification of enterococci: A primer pair and probe for the large subunit ribosomal RNA gene of enterococci for use in a real-time nucleic acid sequence based amplification (NASBA) assay.... Agent: Smith Hopen, Pa

20070243559 - Immunoassay method: An immunoassay method including the steps of: preparing a measuring sample by mixing a specimen with an immunoreactive substance, capable of specifically binding to a defined analyte, allowing the sample to react for a given reaction time, measuring a signal related to interactions of the immunoreactive substance with the analyte... Agent: Rankin, Hill, Porter & Clark LLP

20070243567 - Beta cell mimicking control algorithm for artificial pancreas: The invention is a method of controlling an artificial pancreas. The method includes reading and recording a current plasma glucose level. The method includes computing glucose in beta cell if a current plasma glucose level is greater than a threshold value, and continuing the step of reading and recording a... Agent: Law Offices Of Clement Cheng

20070243578 - Method, system, apparatus and kit for semen analysis: The present invention is generally directed towards a method, system, apparatus and/or kit for collecting samples of bodily fluids, and more specifically towards collection of supplies that enable a lay person to collect and analyze a semen sample for use at home for male fertility or in the animal husbandry... Agent: Kevin Lynn Wildenstein

20070243584 - Tetramerizing polypeptides and methods of use: The present invention relates to a method of preparing a tetrameric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a vasodialator-stimulated phosphoprotein (VASP) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion... Agent: Zymogenetics, Inc. Intellectual Property Department

20070243518 - Continuous cardiac perfusion preservation with peg-hb for improved hypothermic storage: Efforts to extend myocardial preservation for transplantation by perfusion with prior crystalloid based solutions have been limited by edema and compromised function. Hypothermic perfusion preservation with a polyethylene glycol (PEG) conjugated hemoglobin solution extends preservation times. The polyethylene glycol (PEG) conjugated hemoglobin solution comprises PEG-Hb, and at least one of... Agent: Stout, Uxa, Buyan & Mullins LLP

20070243520 - Method for screening an agent for preventing or ameliorating wrinkles: There is provided a screening method which can select a photoaging-preventing or improving agent or a wrinkle-preventing or improving agent with efficiency and reliability. The screening method for a photoaging- or wrinkle-preventing or improving agent selects, as a candidate, a substance inhibiting the expression of keratin 6 and/or keratin 16... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070243523 - Methods and apparatus for the manipulation of particle suspensions and testing thereof: Apparatus and methods are provided for analysis of individual particles in a microfluidic device. The methods involve the immobilization of an array of particles in suspension and the application of experimental compounds. Such methods can also include electrophysiology studies including patch clamp recording, electroporation, or both in the same microfluidic... Agent: Wilson Sonsini Goodrich & Rosati

20070243519 - Protecting group for carboxylic acids that can be photolyzed by visible light: The present invention relates to a photolabile compound including a coumarin family caging group covalently bound to an organic moiety containing a carboxyl group, an amino group, a sulfhydryl group, and/or a hydroxyl group. The photolabile compound, upon absorbing visible light, releases the organic moiety. Also disclosed is a method... Agent: Nixon Peabody LLP - Patent Group

20070243526 - Aav capsid library and aav capsid proteins: Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a library from which the capsids are selected are also provided.... Agent: Perkins Coie LLP

20070243525 - Method and a device for the evaluation of biopolymer fitness: A Method for identifying one or a small number of molecules, especially in a dilution of ≦1 μM, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ≦10−14 l,... Agent: Jacobson Holman PLLC

20070243524 - Sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents: The present application discloses and claims polynucleic acids relating to and/or containing HCV polynucleic acid sequences.... Agent: Nixon & Vanderhye, PC

20070243546 - Analysis of methylation using nucleic acid arrays: Arrays for genome-wide analysis of methylation are disclosed. In a preferred aspect arrays comprising a plurality of probes complementary to a plurality of identified CpG islands in the human, mouse and rat genome are disclosed. The arrays may be used to detect methylation within CpG islands in samples from human,... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070243553 - Analytical method and kit: Analytical methods using RNA probes for the detection or analysis of nucleic acid sequences is described. These probes are contacted with a sample suspected of containing the nucleic acid sequence and if they form duplexes, they are hydrolysed. This may be done, for example during an amplification reaction. AMP generated... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20070243529 - Aptamer selection method: The present invention provides a method for the selection of aptamer sequences and aptamers identified using the method. The method comprises immobilizing a library oligonucleotide by forming a duplex with an antisense oligonucleotide, reating the duplex molecule with a target and collecting oligonucleotide molecules which dissociate from the duplex structure.... Agent: Occhiuti Rohlicek & Tsao, LLP

20070243551 - Assay system using labeled oligonucleotides: The present invention provides a useful system for assays that comprises a solid support, a plurality of capture oligonucleotides immobilized onto the solid support, and complementary oligonucleotides attached to capture ligands. A detectable label can be directly attached to the capture oligonucleotides or the complementary oligonucleotides. The labeled oligonucleotides can... Agent: Beckman Coulter Inc. C/o Sheldon Mak Rose & Anderson

20070243548 - Calumenin-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance: Methods are disclosed for diagnosing chemotherapeutic drug resistance in neoplastic cells by detecting an increase in the expression of calumenin in such neoplastic cells as compared to the level of expression of calumenin protein in a non-MDR neoplastic cell. In addition, disclosed are methods for treating neoplastic cells, including reversing... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070243541 - Compositions and methods for generating antigen-binding units: The present invention provides non-single-chain antigen-binding units that is stabilized by leucine zipper sequences. The experimental design is particularly useful for generating and screening for Nsc Abus that remain the binding capabilities to their respective antigens within a cell. The present invention also provides recombinant polynucleotides, host cells and kits... Agent: Morgan, Lewis & Bockius LLP (sf)

20070243544 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent: Casimir Jones, S.c.

20070243549 - Enrichment of circulating fetal dna: A non-invasive screening or diagnostic method for determining the likelihood of a fetus with a genetic abnormality or a potential pregnancy complication, which utilizes a liquid blood sample from a pregnant woman. Antibodies specific to a section of histone 3.1 which is exposed to a far greater extent in chromatin... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070243539 - Genetic variants of human inositol polyphosphate-4-phosphatase, type i (inpp4a) useful for prediction and therapy of immunological disorder: Atopic asthma is a chronic, inflammatory lung disease characterized by recurrent breathing problems in response to an allergen. Platelets play an important role in this allergic inflammatory process, by releasing preformed mediators like platelet factor 4 (PF4) and regulated upon activation in normal T cells expressed and secreted (RANTES) upon... Agent: Morgan & Finnegan, L.L.P.

20070243537 - Human sample matching system: Methods and apparatus for a collecting a human odor or DNA sample (S), analyzing the sample (S) and then determining a good romantic match is disclosed. In one embodiment, a customer purchases an AromaMatch™ Test Kit (14), which comprises a bottle of cleaning solution (20), a cotton ball (22) a... Agent: Giaccherini

20070243540 - Kits and methods for identification, assessment, prevention and therapy of breast cancer: Disclosed herein are methods for detecting and identifying potential breast cancer biomarkers in an individual patient. Also disclosed are newly discovered breast cancer markers set forth in Tables I, II and III, associated with the cancerous state of breast cells. It has been discovered that a higher than normal level... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20070243545 - Method for combining immunostaining and fish using covalently binding fluorophores: Among embodiments is disclosed a process for immunostaining a sample such that the stain is stable under FISH conditions... Agent: Kelley Drye & Warren LLP

20070243543 - Method for isolation of transcription termination sequences: The invention relates to efficient, high-throughput methods, systems, and DNA constructs for identification and isolation of transcription termination sequences. The invention relates further to specific terminator sequences identified by said methods isolated from rice.... Agent: Connolly Bove Lodge & Hutz, LLP

20070243528 - Methods for detecting polymorphisms using arms or rflp: The invention provides a method for the detection of a polymorphism in OATP8 in a human. The method for detection of a nucleic acid polymorphism is selected from amplification refractory mutation system and restriction fragment length polymorphism. The invention also provides use of the method to assess the pharmacogenetics of... Agent: Fish & Richardson P.C.

20070243538 - Methods for identification of alport syndrome: Animals with mutations in COL4α4 present with autosomal recessive Alport Syndrome (ARAS). Through sequencing of COL4α4, the mutation causative for ARAS in the English Cocker Spaniel (ECS) has been identified. The resulting protein is severely truncated due to a premature stop codon in exon 3. This nonsense mutation occurs in... Agent: Patrea L. Pabst Pabst Patent Group LLP

20070243536 - Methods for identifying novel pesticidal gene homologues: Methods and compositions for identifying novel pesticidal gene homologues are provided. Specifically, the methods of the invention comprise systematically designing oligonucleotide primers that are specific for a pesticidal gene of interest and performing successive rounds of PCR amplification of nucleic acid material from a microorganism, particularly a Bacillus thuringiensis strain,... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20070243535 - Methods for increasing accuracy of nucleic acid sequencing: The invention provides methods for improving the accuracy of a sequencing-by-synthesis reaction by sequencing at least a portion of a template and at least a portion of template complementary sequence.... Agent: Edwards Angell Palmer & Dodge LLP

20070243531 - Methods of diagnosing colorectal cancer and reagents therefor: The present invention relates to assays for diagnosing colorectal cancer or a predisposition therefore or the neoplastic potential of a colorectal polyp wherein hypermethylation of an MCC gene promoter is determined. The invention provides various multi-analyte diagnostic tests and reagents for performing these diagnostic/predictive assays.... Agent: Bozicevic, Field & Francis LLP

20070243552 - Novel approach to molecular diagnosis of human papillomavirus-related diseases: The present invention relates to an accurate, sensitive, and efficient sequential or concurrently sequential method for molecular diagnosis of human papillomavirus (HPV)-based disease, where the method improves the accuracy and reliability of diagnostic and prognostic assessments of HPV-based disease. The method of the invention comprises a primary screen of a... Agent: Morgan & Finnegan, L.L.P.

20070243530 - Nucleic acid probes and broad-range primers from regions in dna directed rna polymerase subunit b genes, and methods in which they are used: The invention relates to nucleic acid probes and to broad-range primers that are useful in the identification of bacterial species and the diagnosis of bacterial infections. Especially, the invention relates to specific nucleic acid probes that originate from hyper-variable regions situated near the conserved sequences of the gene for RNA... Agent: Buchanan, Ingersoll & Rooney PC

20070243534 - Probe density considerations and elongation of self-complementary looped probes where probes are attached to a solid phase: In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method... Agent: Eric P. Mirabez

20070243533 - Products and methods of organism identification in nutritional supplements: Certain plant species are used as nutritional or dietary supplements. Several specific regions within these supplements have been identified as particularly useful sources of diagnostic DNA sequences. These regions are found in the nuclear genome, the chloroplast genome and the mitochondrial genome. The sequences can be used to design nucleic... Agent: Kile Goekjian Reed & Mcmanus

20070243542 - Rapid and efficient capture of dna from sample without using cell lysing reagent: Nucleic acids can be made available for amplification or other treatment after admixture of a sample with specific weakly basic polymers to form a precipitate with the nucleic acids at acidic pH. After removing non-precipitated materials, the pH is then made basic, thereby releasing the nucleic acids from the polymer.... Agent: Philip S. Johnson Johnson & Johnson

20070243527 - Rigidized trimethine cyanine dyes: c

20070243532 - System and method of detecting a microorganism: A system for detecting the presence or absence of microorganisms in various types of samples is described. A process for detecting the presence or absence of microorganisms in samples is also described.... Agent: Cognis Corporation Patent Department

20070243547 - Use of tumor susceptibilty gene 101 (tsg 101) as a prognostic and diagnostic marker: The present invention discloses the link between oncogenic Ras and TSG101 and the negative effect of TSG101 on the expression of p21 in ovarian cancer. The present also discloses the use of TSG101 as a prognostic, diagnostic marker and a potential therapeutic target in cancer, especially ovarian cancer.... Agent: Benjamin Aaron Adler Adler & Associates

20070243554 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070243560 - Method for examining kidney diseases: Method for examining kidney disease, which comprises detecting fatty acid binding protein derived from kidney tissues, which is present in specimen collected from mammal excluding Rodents. By the present method, it is possible to obtain test results which may be very important information for diagnosis of prognosis of kidney disease,... Agent: Birch Stewart Kolasch & Birch

20070243555 - Method of detecting the cystic fibrosis transmembrane conductance regulator (cftr) at cell exterior: The present invention provides a recombinant nucleic acid encoding a modified cystic fibrosis transmembrane conductance regulator (CFTR) protein. The nucleic acid is modified by the insertion of a first heterologous segment encoding a detectable epitope in a region encoding an extracytoplasmic loop, such as at least one of EL1 through... Agent: Myers Bigel Sibley & Sajovec

20070243558 - Peptide stabilization: The present invention is directed to the use of DMSO for the stabilization of temperature sensitive proteins and peptides, such as gastrin, against degradation in a mammalian biological sample, such as a serum or plasma sample.... Agent: Birch Stewart Kolasch & Birch

20070243557 - Rapid tuberculosis detection method: Methods for diagnosing Mycobacterium tuberculosis infection in a human that include providing blood serum, contacting the serum with an Eis antigen fixed on a substrate, thereby forming complexes of Eis antigen with a human antibody that binds to the Eis antigen, contacting the antibody/Eis complexes with a labeled anti-human secondary... Agent: Quarles & Brady LLP

20070243556 - Smart combinatorial operando spectroscopy catalytic system: A device and combinatorial method is disclosed for screening a plurality of catalytic materials simultaneously while determining the dynamic bulk and surface nature of the catalytic materials being screened under reaction conditions and surface chemical kinetic and mechanistic information for determining the structure-activity/selectivity relationship of the catalytic materials, and for... Agent: Banner & Witcoff

20070243563 - Aflatoxin-albumin adduct measurement and the uses thereof: The invention discloses one immunoassay for aflatoxin-albumin adducts measurement in serum. In Particular, serum pretreatments including albumin precipitation, resuspension, dialysis, albumin digestion, enzyme precipitation and aflatoxin extraction, centrifugation and resuspension are unnecessary, which is convenient for clinical routine serum testing. The invention also discloses their clinical uses in rapid measurement... Agent: Apex Juris, PLLC Tracy M Heims

20070243564 - Identification of antibody-producing cells: The present invention provides an automated homogeneous assay for identifying an antibody-producing cell producing an antibody which binds to a selected antigen, especially a high yielding antibody-producing cell.... Agent: Woodcock Washburn LLP

20070243565 - Luminescence resonance energy transfer (lret) assays for clostridial toxin activity: Clostridial toxin substrates comprising a lanthanide donor complex, an acceptor, and a Clostridial toxin recognition sequence including a cleavage site; methods for determining the activity of a Clostridial toxin from a test sample using such Clostridial toxin substrates; cell compositions comprising such Clostridial toxin substrates and a Clostridial toxin receptor;... Agent: Dean G. Stathakis (t2-7h) Allergan, Inc.

20070243561 - Prognostic markers in chronic lymphocytic leukemia: Methods and compositions for detecting a form of chronic lymphocytic leukemia in a subject are described which allow for distinguishing more aggressive forms of the disease from less aggressive forms. Particularly described methods include assaying a sample obtained from the subject having or suspected of having chronic lymphocytic leukemia for... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20070243562 - Lectins for analyzing sugar chains and method of using the same: It is expected that lectins of a needed number of types appropriately corresponding the variation of sugar chains, if available, are highly useful as tools for analyzing various sugar chains. From a lectin library containing plural types of lectins or an arbitrary mass of lectins containing plural types of lectins,... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070243566 - Genetically engineered pyrroloquinoline quinone dependent glucose dehydrogenase comprising an amino acid insertion: The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and 429 as corresponding to the amino acid sequence known from Acinetobacter calcoaceticus, to genes encoding such variant s-GDH, to proteins of such s-GDH variants with improved... Agent: Barnes & Thornburg LLP (roche)

20070243569 - Protein kinase-inducible domains: Applicants have used protein design to develop novel functional protein architectures, termed protein kinase-inducible domains, whose structures are dependent on phosphorylation by specific protein kinases or are dependent on dephosphorylation by specific protein phosphatases. Applicants have designed kinase-inducible domains based on a modular architecture, which allows kinase-inducible domains to be... Agent: Potter Anderson & Corroon LLP Attn: Kathleen W. Geiger, Esq.

20070243568 - Specific substrates for o6-alkylguanine-dna alkyltransferase: The invention relates to substrates for O6-alkylguanine-DNA alkyltransferases (AGT) of formula R1-A-X—CH2—R3—R4-L1, wherein A is a group recognized by AGT as a substrate, X is oxygen or sulfur, R1 is a group —R2-L2 or a group R5, R2 and R4 are, independently of each other, a linker, R3 is an... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070243570 - Apoptosis inducer for cancer cell: The present invention revealed that by suppressing the expression of the WRN gene, the BLM gene, or the RecQ1 gene, which belong to the RecQ helicase family, apoptosis is induced in various cancer cells and their proliferation is suppressed. Compounds that suppress the expression of RecQ helicase family genes or... Agent: Seed Intellectual Property Law Group PLLC

20070243571 - Method for measurement of activity of homocysteinethiolactone hydrolyzing enzyme: Disclosed is a method for measurement of the activity of the homocysteinethiolactone hydrolyzing enzyme in a sample, which method comprises mixing and reacting γ-thiobutyrolactone and the sample in the presence of a cholinesterase inhibitor, and measuring 4-mercaptobutyric acid thereby produced. The method is safe and easy in operation, for it... Agent: Millen, White, Zelano & Branigan, P.C.

20070243575 - Compositions and methods for treatment of immune-related disease: The invention provides methods for identifying novel agents for modulating the immune system or compounds useful for modulating immune responses. Also provided are compositions and methods for preventing or treating immune-related diseases, infectious diseases, or neoplastic diseases in mammalian subjects. Pharmaceutical compositions are provided for treating such diseases.... Agent: The Scripps Research Institute

20070243572 - Interacting microhabitat array and uses thereof: The invention is directed to an interacting microhabitat array for microorganisms having more than one microhabitat in a substrate in which at least two microhabitats are connected in series by at least one corridor. The corridor is of sufficient size to allow the microorganism to move between microhabitats in a... Agent: Connolly Bove Lodge & Hutz, LLP

20070243573 - Method and apparatus for immobilizing cells, and cell-immobilized substrate: A method and apparatus for efficiently immobilizing cells on a substrate without damaging the cells, and a cell-immobilized substrate is provided. Cells 4a contacting a substrate 2 is irradiated with light 10 which includes light having a wavelength of 330 to 410 nm, thereby adhering cells 4a to the substrate... Agent: Ostrolenk Faber Gerb & Soffen

20070243576 - Method to confirm immunosuppression in human patients by measuring lymphocyte activation: Methods for measuring the function of lymphocytes and their responses to mitogens or specific antigens, with or without co-stimulatory agents, is provided. The methods are suitable for measurement of the responses of lymphoid cells when they are a subpopulation of cells, and also for measuring the function of specific subsets... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070243574 - Vascular mimic for drug and device evaluation: The present invention provides tissue engineered vascular grafts (TEVGs) and Blood Vessel Mimics (BVMs) and methods for using TEVGs as BVMs in in vitro model systems for the evaluation of intravascular devices and drugs. The present invention additionally relates to devices and methods for preparing TEVGs, BVMs and BVM model... Agent: Thelen Reid Brown Raysman & Steiner LLP

20070243577 - Method for the detection of apoptosis by determining apoptosis-specific markers released into an extracellular medium through cellular release mechanisms: A method for the detection of apoptosis by determining presence, amount, or activity of apoptosis-specific markers released from at least one cell undergoing apoptosis into an extracellular medium through cellular release mechanisms is disclosed. The extracellular medium includes body fluids, in particular urine, inflammatory fluid, serum, liquor, or cell culture... Agent: Jacobson Holman PLLC

20070243583 - Artificial disulfide isomerases and uses thereof: The present invention provides artificial enzymes comprising, e.g., an N-terminal domain derived from E. coli FkpA that allows for dimerization and provides a substrate binding region, and a C-terminal thioredoxin domain derived from E. coli DsbA. Similar to DsbC, such de novo designed chimeric (hybrid) FkpA-DsbA enzymes function, as disulfide... Agent: Fulbright & Jaworski L.L.P.

20070243580 - Basb019 proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses: The invention provides BASB019 polypeptides and polynucleotides encoding BASB019 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.... Agent: Dechert LLP

20070243586 - Novel organic anion transport proteins: The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for... Agent: Louis J. Wille Bristol-myers Squibb Company

20070243585 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070243581 - Process for producing dipeptides: The present invention provides: a protein having dipeptide-synthesizing activity or a protein for dipeptide synthesis; DNA encoding the protein having dipeptide-synthesizing activity or the protein for dipeptide synthesis; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein having dipeptide-synthesizing activity; an... Agent: Fitzpatrick Cella Harper & Scinto

20070243582 - Process for producing protein a-like protein with use of brevibacillus genus bacterium: The present invention relates to an efficient and economical process for producing a protein A-like protein. Hosts such as Escherichia coli and Bacillus subtilis have been used in the production of a protein A-like protein using a genetic recombination technique and however, their low productivity has been a big cause... Agent: Sughrue Mion, PLLC

20070243579 - Selection markers useful for heterologous protein expression: Selection markers in prior art systems are based on resistance genes or on complementation of auxotrophic mutations. The requirement for expression of these markers is conditional e.g. on the presence of an antibiotic, or on the absence of a nutrient. In contrast, the selection markers used in this invention arc... Agent: Arent Fox PLLC

20070243587 - Using a reverse genetic engineering platform to produce protein vaccines and protein vaccine of avian influenza virus: The present invention relates to a preparation method of protein vaccines, and comprises the steps of: (a) providing at least one amino acid sequence of an epitope of a target antigen protein; (b) converting the amino acid sequence into a nucleic acid sequence and modifying the codons; (c) synthesising a... Agent: Bacon & Thomas, PLLC

20070243589 - Antibodies against human il-22 and uses therefor: The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in particular. The disclosed compositions and methods may be used for... Agent: Wyeth/finnegan Henderson, LLP

20070243588 - Factor vii or viia - like molecules: Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates are provided. Methods of treatment by administering a FVII or FVIIa conjugate are provided.... Agent: Maxygen, Inc. Intellectual Property Department

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