Chemistry: molecular biology and microbiology inventions 10/07

20070248952 - Compositions and methods related to profiling a plurality of cells based on peptide binding: Methods and compositions are described for classifying cells and/or peptides that associate or bind with a particular characteristic pattern to a plurality of cells or cell lines. Aspects of the invention also include the use of peptide(s) having an appropriate binding characteristic to deliver a drug to a cell or... Agent: Fulbright & Jaworski L.L.P.

20070248970 - Compositions and methods for detecting keratoconus: The invention provides a method and assay kits for detecting keratoconus, including sub clinical keratoconus, in a specimen. The method comprises assaying a specimen of corneal epithelium for the presence of an expression product of the AQP5 gene. The invention further provides a novel gene, KC6, that exhibits cornea-specific expression,... Agent: Karen S. Canady Canady & Lortz LLP

20070248977 - Method and apparatus for supporting analysis of gene interaction network, and computer product: Detailed information of each analysis subject partial network is displayed on a left pane of a screen. The detailed information includes the number of nodes, the number of edges, and accumulative coverage of the analysis subject partial network for each disease. Based on the detailed information, a user can designate... Agent: Staas & Halsey LLP

20070248991 - Base carrier for detecting target substance, element for detecting target substance, method for detecting target substance using the element, and kit for detecting target substance: An element to be used for detecting a target substance by using a capturing body for target substance and using surface plasmon resonance has a structure in which the metal structure having a particular pattern is located on a spherical support. Thus configured element for detecting the target substance can... Agent: Fitzpatrick Cella Harper & Scinto

20070248989 - Method and kit for the early detection of impaired renal status: A method and kit for identifying the presence of an early biomarker of impaired renal status following a renal event in a mammalian subject. The method typically comprises (a) providing a body fluid sample obtained from a mammalian subject following a renal event; and (b) detecting in the provided sample... Agent: Hasse & Nesbitt LLC

20070248999 - Method for determining the concentration of vital epithelial tumor cells in a body fluid: A method for determining the concentration of vital epithelial tumor cells in a body fluid is disclosed. The method comprises obtaining from the body fluid of a test subject a test specimen, labeling the epithelial tumor cells contained in said test specimen, applying the test specimen to a support, where... Agent: Fish & Richardson P.C.

20070249007 - Method and apparatus for the management of diabetes: A biological chip device having a biologic materials component according to embodiments of the invention may provide the ability to sense levels of blood parameters (e.g., glucose, insulin, and glucagon levels) in a patient. In certain embodiments of the invention, a device may include therapeutic abilities in which a portion... Agent: Intellectual Property Group Fredrikson & Byron, P.A.

20070249019 - Purification processes for isolating purified vesicular stomatitis virus from cell culture: Novel purification processes for obtaining vesicular stomatitis virus (VSV) of improved purity from mammalian cell culture are described herein. More particularly, in certain embodiments, a process is described for purifying VSV from cell culture fluid of a mammalian cell culture infected with VSV, the process comprising: clarifying the cell culture... Agent: Howson And Howson/wyeth Cathy A. Kodroff

20070248942 - Method for selectively removing virus and leukocytes, removing material and removing apparatus: It is intended to provide a method whereby a virus and leukocytes can be simultaneously eliminated from virus-containing blood and platelets can be recovered at a high yield, and a material and an apparatus therefor. A water-soluble carrier having surface which is capable of capturing a virus and leukocytes in... Agent: Young & Thompson

20070248941 - Storage and maintenance of blood products including red blood cells and platelets: Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond current periods. Additionally, the materials so treated exhibit extended circulation... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070248946 - Catheter testing system and uses thereof: The present invention relates generally to devices and systems for detecting infection within catheters. In particular, the present invention provides catheter testing systems configured to sterilely collect a biological sample from the interior of a catheter for purposes of testing the biological sample (e.g., for the presence of fibrin, sepsis,... Agent: Medlen & Carroll, LLP

20070248943 - Displaying cellular analysis result data using a template: In accordance with the principles of the invention, methods, systems, and computer-readable mediums are provided for displaying cellular analysis result data including accessing cellular analysis result data; determining frequency information of a plurality of cell populations from the cellular analysis result data; associating frequency information of each of the plurality... Agent: Beckman Coulter, Inc.

20070248948 - Method of measuring residual cancer and predicting patient survival: Method of Measuring Residual Cancer and Predicting Patient Survival Disclosed is a method for determining survival and relapse of a patient undergoing therapy for a tumor by determining a residual cancer burden index based on the bidimensional diameters of a primary tumor bed of said tumor in a resection specimen,... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070248944 - Preventive and remedy for collagen or elastin metabolic disorder: The present invention relates to a prophylactic agent or a therapeutic agent for a disorder of collagen or elastin metabolism, which comprises a a substance possessing JNK inhibitory activity as an active ingredient.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070248947 - Reagents and methods for using human embryonic stem cells to evaluate toxicity of pharmaceutical compounds and other chemicals: The invention provides biomarker profiles of cellular metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human embryonic stem cells (hESC) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070248945 - Stem cells derived from uniparental embryos and methods of use thereof: Embryonic stem cells derived from uniparental embryos and methods of use thereof are disclosed.... Agent: Dann, Dorfman, Herrell & Skillman

20070248951 - Determination method and determination kit: Disclosed herein are a determination method capable of determining the presence or absence of an anti-HIV antibody in a sample with accuracy even if an operation of cleaning is omitted and a determination kit to be used for the determination method. The determination method is as follows. First, a liquid... Agent: Greenblum & Bernstein, P.L.C

20070248953 - Pressure transduced chemical assay and method: An assay system has a chamber that receives a test strip onto which a sample comprising an analyte has been placed. The chamber is in gaseous communication with a piezoelectric material that generates an electrical signal in response to a pressure change in the chamber that is caused by a... Agent: Fish & Associates, PC Robert D. Fish

20070248949 - Sensitive and specific test to detect sars coronavirus: The invention provides a simple, specific and sensitive test for the presence of SARS coronavirus. Kits comprising primers useful in the test are also provided.... Agent: Birch Stewart Kolasch & Birch

20070248950 - Supported polydiacetylene 3-d arrays for flourescent or phosphorescent detection: Supported three-dimensional arrays of a polydiacetylene backbone bonded to and supported by a solid support in a sample are provided. The bonding is achieved by providing a support having thiol and/or amine groups and epoxy groups and/or maleimide groups, and a polydiacetylene backbone containing the other of thiol and/or amine... Agent: Connolly Bove Lodge & Hutz LLP

20070248963 - method for identifying pre-neoplastic and/or neoplastic states in mammals: The present invention relates to methods of identifying pre-neoplastic and/or neoplastic states in mammals and in particular to a method for identifying pre-neoplastic and neoplastic cells in tissues and body fluids, based on differential expression of purinergic receptors in these cells.... Agent: Ivor R. Elrifi, Esq. Mintz, Levin, Cohn, Ferris, Glovsky And

20070248960 - Arrays containing cleavable rnai molecules: A nucleic acid array is provided, as well as methods of using the same. In certain embodiments, the nucleic acid array comprises: a) a substrate; and b) an array of features on a surface of the substrate, where the features comprise interfering RNA molecules that are linked to the surface... Agent: Agilent Technologies Inc.

20070248982 - Automatic threshold setting and baseline determination for real-time pcr: The invention discloses a system and methods for quantitating the presence of nucleic acid sequences by evaluation of amplification data generated using real-time PCR. In one aspect, the methods may be adapted to identify a threshold and threshold cycle for one or more reactions based upon evaluation of exponential and... Agent: Kilyk & Bowersox, P.l.l.c.

20070248962 - Compositions and methods for human metapneumovirus monoclonal antibodies: The present invention discloses specific human metapneumovirus monoclonal antibodies. The antibody is at least two-fold less reactive with non-human metapneumoviruses including, but not limited to, respiratory viruses or avian metapneumoviruses. Further, the antibody is at least two-fold more reactive with a human metapneumovirus (i.e., for example, Type A or Type... Agent: Medlen & Carroll, LLP

20070248965 - Compositions and methods for the detection of a nucleic acid using circular probes in a cleavage reaction: The invention provides a method of generating a signal indicative of the presence of a target nucleic acid sequence in a sample by forming a cleavage structure by incubating a sample comprising a target nucleic acid sequence with a probe, nucleic acid polymerase, nuclease and optionally a primer. The target... Agent: Agilent Techologies Inc

20070248969 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent: Casimir Jones, S.c.

20070248957 - Encoded solid supports for biological processing and assays using same: Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The matrix... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20070248959 - Genetic markers for obesity: The present invention is directed to new genetic variants or polymorphisms at the perilipin locus (PLIN) including PLIN1: 6209T (allele 1)>C (allele 2); PLIN3 10171 (allele 1) A>T (allele 2); PLIN4: 11482G (allele 1)>A (allele 2); PLIN5: 13041A (allele 1)>G (allele 2) and PLIN6: 14995A (allele 1)>T (allele 2), and... Agent: David S. Resnick

20070248974 - Identification of a novel gene underlying familial spastic paraplegia: Methods of identifying polymorphisms associated with hereditary spastic paraplegia (SPG), are described. The polymorphisms associated with SPG include specific mutations in the receptor expression enhancing protein 1 (REEP1) gene. Also described are methods of diagnosis of SPG.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070248976 - Inverted orientation for a microplate: A method of conducting amplification comprising loading a liquid polynucleotide sample into a well of a microplate and covering the well of the microplate with a cover, such that the cover fluidly seals the liquid polynucleotide sample within the well. The method then comprises inverting the microplate such that the... Agent: Harness, Dickey & Pierce, P.L.C

20070248964 - Method and device for detection of nucleic acids and/or polypetides: A method for the detection and/or quantification of at least one target nucleic acid or target polypeptide in a sample of nucleic acids or polypeptides comprising the steps of: a) providing a sample comprising nucleic acids or polypeptides; b) labeling the nucleic acids or polypeptides with a ligand conjugate, the... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20070248956 - Methods and compositions for autism risk assessment: Methods and compositions are provided for evaluating an individual for relative genetic risk for autism, for identifying a form of a genetic polymorphism that is linked to autism, and for evaluating whether a compound affects autism.... Agent: Amster, Rothstein & Ebenstein LLP

20070248961 - Methods for detecting mutations in jak2 nucleic acid: The present invention relates to methods for detecting JAK2 nucleic acid in acellular bodily fluid samples from patients with neoplastic disease and determining if the nucleic acid contains one or more mutations or one mutation and one deletion. The methods are useful for diagnosing patients that have cells with mutations... Agent: Foley & Lardner LLP

20070248975 - Methods for monitoring the expression of alternatively spliced genes: Methods, probe arrays and computer software products are provided for determining the arrangement of sequence elements. In one embodiment, methods for making and using exon chips are provided. The exon chips may be used to identify and quantify splice variants.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070248979 - Methods of enriching for and identifying polymorphisms: The invention encompasses methods for enriching for and identifying a polymorphism within a nucleic acid sample either by separating a subset of a nucleic acid sample or by selectively replicating a subset of a nucleic acid sample such that the polymorphism is contained within a nucleic acid population with reduced... Agent: Agilent Techologies Inc

20070248980 - Methods of enriching for and identifying polymorphisms: The invention encompasses methods for enriching for and identifying a polymorphism within a nucleic acid sample either by separating a subset of a nucleic acid sample or by selectively replicating a subset of a nucleic acid sample such that the polymorphism is contained within a nucleic acid population with reduced... Agent: Agilent Techologies Inc

20070248958 - Microfluidic devices: Methods and devices for the interfacing of microchips to various types of modules are disclosed. The technology disclosed can be used as sample preparation and analysis systems for various applications, such as DNA sequencing and genotyping, proteomics, pathogen detection, diagnostics and biodefense.... Agent: Wilson Sonsini Goodrich & Rosati

20070248972 - Page-4, an x-linked gage-like gene expressed in normal and neoplastic prostate, testis and uterus, and uses therefor: PAGE-4 is a gene preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus and placenta, as well as in prostate cancer, testicular cancer and uterine cancer. This expression pattern makes it a target for diagnosis and for vaccine based therapy of neoplasms of prostate, testis... Agent: Klarquist Sparkman, LLP

20070248966 - Parallel high throughput single molecule sequencing process: The invention relates to a process and to an apparatus for parallel high throughput sequencing of nucleic acid molecules, in particular in the single molecule format. The present invention further relates to a process and an apparatus for a parallel high throughput study of enzyme-substrate interactions, in particular in the... Agent: Fulbright & Jaworski, LLP

20070248981 - Predicting mortality and detecting severe disease: Measurement of circulating ST2 and/or IL-33 concentrations is useful for the prognostic evaluation of subjects, in particular for the prediction of adverse clinical outcomes, e.g., mortality, and the detection of severe disease.... Agent: Fish & Richardson PC

20070248954 - Primers for use in detecting beta-lactamases: Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain β-lactamase genes. The primers can be employed in methods to identify nucleic acid characteristic of family-specific (and even group-specific) β-lactamase enzymes in samples, and particularly, in clinical isolates of Gram-negative bacteria.... Agent: Mueting, Raasch & Gebhardt, P.A.

20070248968 - Probe of human papillomavirus and dna chip comprising the same: Oligonucleotide probes for analyzing 40 types of HPV were synthesized, and DNA chips were produced by using the oligonucleotide probes. The synthesis of the oligonucleotide probes is based on clones of L1 and E6/E7 genes of 35 types of HPV obtained from cervical cell specimens from 4,898 Korean adult women... Agent: Osha Liang L.L.P.

20070248971 - Programming microfluidic devices with molecular information: The invention provides a microfluidic device having a plurality of chambers each containing separately deposited reagents. The invention also provides an efficient PCR-based method for producing a linear expression template. The invention also provides methods for analyzing interactions between molecules, involving flow-deposition of expression templates on the substrate of chambers... Agent: Townsend And Townsend And Crew, LLP

20070248967 - Reporter assay using secrectory luminescent enzymes: It is an objective of the present invention to provide a method for convenient and highly sensitive reporter assay. A secretory luminescent enzyme is used as a reporter protein so as to evaluate the expression, functions, transcriptional activity, or transcriptional control functions of a foreign gene or a foreign DNA... Agent: Sughrue Mion, PLLC

20070248978 - Steroid responsive nucleic acid expression and prediction of disease activity: The invention relates to methods useful for diagnosing and monitoring the steroid responsiveness of a subject by detecting expression of steroid modulated genes and for predicting transplant rejection and non-rejection.... Agent: Morrison & Foerster LLP

20070248973 - Terminating substrates for dna polymerases: This invention concerns novel terminating substrates for DNA polymerases. The substrates are nucleoside triphosphates labeled with lanthanide chelates.... Agent: Buchanan, Ingersoll & Rooney PC

20070248955 - Use of genetic polymorphisms to predict drug-induced hepatotoxicity: IL1A or a gene located near IL1A on chromosome 2q14 may contribute to hepatotoxicity, as measured by increased serum levels of aspartate transaminase, during N-benzoyl-staurosporine treatment for macular edema. Accordingly, genetic polymorphisms in the IL1A gene are useful as biomarkers for predicting staurosporine derivative-mediated hepatotoxicity.... Agent: Novartis Corporate Intellectual Property

20070248988 - Binding molecules and methods of use thereof: Binding molecules are described.... Agent: Lahive & Cockfield, LLP

20070248983 - Device and method for simultaneously identifying blood group antigens: The invention relates to a device for simultaneously, qualitatively or quantitatively identifying a number of analytes in a liquid sample. The device comprises a membrane with: a charging zone for applying the liquid sample; at least two indicator zones, which can interact with the analytes, and at least one absorption... Agent: Ratnerprestia

20070248985 - Functional porous substrates for attaching biomolecules: A substrate comprising a microporous microstructure, an interlayer over at least a portion of the microstructure and a functional layer attached to the interlayer, the functional layer having functional sites with a density of at least 50 nanomoles/cm2.... Agent: Allan M. Weatcraft W.l. Gore & Associates, Inc.

20070248990 - Method for stabilizing functional groups on a surface of a polymer used as solid support for making microarrays: The present invention concerns a new and simplified method for obtaining a polymer surface activated with a high density of aldehyde functions which are stable with time and ready to react covalently with amino groups present on a great number of different molecules used as capture probes according to a... Agent: Knobbe Martens Olson & Bear LLP

20070248992 - Method for the determination of the composition of textile fibers: Method for the recognition and the quantitative evaluation of mixed textile fibers of animal source, comprising the steps of: preparing and conditioning of the fibers to be analysed; extracting of the proteins by means of demolition of the fibers, and subsequent centrifugation; dosing the mixture of proteins contained in the... Agent: Matthias Scholl

20070248984 - Methods and compositions for separating cells: The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover rare cell types in high yield.... Agent: Fish & Richardson P.C.

20070248994 - Sensor constructs and detection methods: Sensor constructs for detecting the presence of an analyte in a sample comprising a molecular scaffold, a pair of labels which interact via Förster resonance energy transfer, and at least one molecular recognition domain for binding the analyte. A changed optical signal is produced when the analyte is bound by... Agent: Sheldon Mak Rose & Anderson PC

20070248986 - Systems and methods for predicting an individual's risk of developing rheumatoid arthritis: Methods for predicting the likelihood of development of rheumatoid arthritis for individuals that present with recent-onset undifferentiated arthritis. The methods are based on the determination of a set of clinical parameter values and determining a predicted risk for developing rheumatoid arthritis by correlating the parameter values with predefined risk values... Agent: Knobbe Martens Olson & Bear LLP

20070248987 - Target substance detection material and method and kit for detecting target substance: In the present invention, a target substance detection material, which includes a metal structure, a target substance capturing unit, and a polymer matrix retaining the metal structure and the target substance capturing unit, captures a target substance, and as a result, the volume of the polymer matrix is changed. Such... Agent: Fitzpatrick Cella Harper & Scinto

20070248993 - Un-supported polymeric film with embedded microbeads: The present invention relates to a systematic process for the creation of functionally organized, spatially patterned assemblies polymer-microparticle composites including the AC electric field-mediated assembly of patterned, self supporting organic (polymeric) films and organic (polymeric)—microparticle composite films of tailored composition and morphology; the present invention further relates to the incorporation... Agent: Eric P. Mirabez

20070248998 - Integrin cd18 is a novel stromal stem cell marker and functions to promote osteogenesis: The present invention is directed to a new bone marrow stromal stem cell (BMSSC) marker, CD18, for use in selecting a population of cells enriched in BMSSCs, from bone marrow cells, adipose cells, or peripheral blood. The invention is further directed to methods for selecting a population of cells enriched... Agent: Evans & Molinelli, PLLC

20070249000 - Method for diagnosing a person having b-cell pathologies: Described is a method for diagnosing a person having or being at risk of developing certain B-cell pathologies, including Sjögren's Syndrome and non-Hodgkin's lymphoma, and excluding patients with symptoms similar to Sjögren's Syndrome but with a different etiology, comprising the following steps: providing a sample of a body fluid or... Agent: Large Scale Biology Corporation

20070249001 - Multiplex detection compositions, methods, and kits: The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention also relates to methods for determining the presence of at least one analyte in... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070248997 - Method of using one-dimensional and multi-dimensional nuclear magnetic resonance to identify compounds that interact with target biomolecules: The invention provides a method using one-dimensional and multi-dimensional NMR spectroscopy for identifying ligands to target biomolecules.... Agent: Glaxosmithkline Corporate Intellectual Property - Uw2220

20070248996 - Modulators of beta-amyloid peptide aggregation comprising d-amino acids: Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected... Agent: Lahive & Cockfield, LLP

20070248995 - Molecules: This invention relates to the gene encoding gerbil neurokinin 1 receptor (gNK1r) and to proteins encoded by the gene, as well as to means of regulating their biological activity. In addition the invention relates to the use of the gene and protein to identify therapeutic agents for controlling asthma, pain,... Agent: White & Case LLP Patent Department

20070249005 - Gastrin hormone immunoassays: The invention provides assay methods for the detection and quantitation of gastrin hormones, including total and free gastrin hormone in a sample. ELISA-type heterogeneous phase assays suitable for use with biological fluid samples such as blood, plasma or other bodily fluids of a mammal, particularly a human subject are provided.... Agent: Fish & Richardson, PC

20070249004 - Gsk3 polypeptides: The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of... Agent: Novartis Vaccines And Diagnostics Inc.

20070249003 - Methods and devices for diagnosis of appendicitis: A method is provided for determining the severity of appendicitis in a patient that includes testing a blood, serum or plasma sample from the patient for the quantity of MRP8/14 in the sample and comparing it with the quantity of MRP8/14 present in standard samples correlated with an appendicitis severity... Agent: Greenlee Winner And Sullivan P C

20070249002 - Systems and methods for characterizing kidney diseases: The present invention relates to methods of diagnosing, predicting and monitoring kidney disorders. In particular, the present invention relates to the diagnosis, prediction and monitoring of kidney disorders by detection of cytokines, cytokine-related compounds and chemokines in urine. The present invention further relates to methods and compositions for assessing the... Agent: Medlen & Carroll, LLP

20070249006 - Assays, antibodies, and standards for detection of oxidized and mda-modified low density lipoproteins: Immunoassays for malondialdehyde-modified low density lipoprotein (MDA-modified LDL) and oxidized low density lipoprotein (OxLDL), monoclonal antibodies (and the cell lines for them) for use in the assays, and a storage-stable standard (which may be used as a calibrator and/or control) are disclosed. MDA-modified LDL and OxLDL are implicated in atherosclerosis... Agent: Stephen P. Gilbert, Esq. Bryan Cave LLP

20070249008 - Cardiovascular prognostic and diagnostic marker: The present invention relates to a method for determining an increased risk of mortality or of a cardiac and/or vascular event in a patient, comprising: determining the sPLA2 activity of said patient, comparing said activity to a predetermined value, a higher sPLA2 activity of said patient as compared to said... Agent: Young & Thompson

20070249009 - Compositions and methods for altering rnai: The present invention relates to compositions and methods for altering (e.g., enhancing) RNAi. In particular, the present invention provides systems and methods for identifying regulators of RNAi. For example, the present invention provides RNAi regulators (e.g., HPS1 and HPS4) and methods of altering (e.g., inhibiting) these regulators in order to... Agent: Medlen & Carroll, LLP

20070249010 - Methods for treating glaucoma and macular degeneration: Inhibition of geranylgeranylation of Rho GTPases and heterotrimeric G-proteins in the aqueous outflow pathway increases aqueous humor outflow, possibly through the tissue relaxation, and through altered cell adhesive interactions and actin cytoskeletal organization in cells of the outflow pathway. In addition, such inhibition is useful for treating age-related macular degeneration.... Agent: Banner & Witcoff, Ltd.

20070249011 - Method for screening fungus-specific antimicrobial agent and kit therefor: An object of the present invention is to provide a method for effectively screening a agricultural chemical candidate or drug candidate. Specifically, an object of the present invention as to a agricultural chemical is to effectively screen, without the use of plants, a agricultural chemical candidate compound that does not... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070249013 - Collections of traceable compounds and uses thereof: The invention concerns the use of a collection of traceable cationic compounds for determining ligands of a receptor whose ligand is unknown or whose ligand useful for specific affinity binding studies is unknown, said traceable cationic compounds being characterized in that they comprise at least one basic amino acid residue... Agent: Young & Thompson

20070249012 - Microbial detection and quantification: Solvatochromic dyes are used herein to indicate the presence of bacteria by incorporating them into various substrates such as films, woven and nonwoven fabrics, paper towels, coform and airlaid materials and bonded carded webs. These dyes change color in response to a change in polarity of the environment. Since water... Agent: Kimberly-clark Worldwide, Inc. Catherine E. Wolf

20070249014 - Labeling and detection of post translationally modified proteins: Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided methods for enzymatically labeling a biomolecules with an azide group.... Agent: Invitrogen Corporation C/o Intellevate

20070249015 - Method of isolation and purification of trypsin from pronase protease and use thereof: The present invention provides methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease mixture in a single affinity chromatography step and uses of the purified SGT.... Agent: Baxter Healthcare Corporation

20070249016 - Method for gene amplification: The present invention provides a double-stranded DNA constructed specially for gene amplification at high speed, a method for gene amplification using the double-stranded DNA and a method to produce proteins. A system to induce artificial gene amplification at high speed was constructed based on the mechanism of gene replication in... Agent: Drinker Biddle & Reath (dc)

20070249017 - Polynucleotides encoding polypeptides involved in amino acid biosynthesis in methylophilus methylotrophus: The present invention provides polypeptides and polynucleotides involved in amino acid biosynthesis in Methylophilus methylotrophus and methods of producing amino acids in microorganisms having enhanced or attenuated expression of these polypeptides and/or polynucleotides.... Agent: Cermak & Kenealy LLP Acs LLC

20070249018 - Reduced overflow metabolism and methods of use: The present invention provides modified bacterial cells and methods for using them. A modified bacterial cell can exhibit increased NADH oxidase activity, decreased ArcA activity, or the combination thereof. The methods include culturing a modified bacterial cell in aerobic conditions. The modified bacterial cell can produce less acetate during the... Agent: Mueting, Raasch & Gebhardt, P.A.

20070249020 - Cytokine zcytor17 ligand polypeptides and polynucleotides: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing... Agent: Zymogenetics, Inc. Intellectual Property Department

20070249021 - Deglycosylated and desialidated long pentraxin ptx3: Deglycosylated long pentraxin PTX3 and desialidated long pentraxin PTX3 are disclosed, as well as processes for their preparation, pharmacological compositions containing them, and their use for the preparation of a medicament for the treatment of diseases in which the use of the long pentraxin PTX is indicated, particularly infectious and... Agent: Lucas & Mercanti, LLP

20070249022 - Activin-actriia antagonists and uses for promoting bone growth: In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070249023 - Process for immobilizing cells on a resin: A process for immobilizing cells is described, particularly procaryotic cells, which includes a step of adsorbing said cells on a resin, wherein such a resin is a weak anionic exchange resin and preferably has amino moieties; when the immobilized cells are UPase and/or PNPase producing cells, nucleosides can be produced... Agent: Akerman Senterfitt

20070249024 - Novel dna synthesis technology with 3'-beaded oligo dna and dna polymerase: A method of synthesizing a desired DNA having a predetermined sequence, comprising the steps of (a) preparing, based on the desired DNA, a plurality of 3′-biotin-immobilized oligo DNA having a fixed length; (b) preparing a starting DNA which has a complementary sequence to a 3′ end of a first immobilized... Agent: Omori & Yaguchi Usa, LLC

20070249025 - Enzymatic resolution of selective estrogen receptor modulators: The present invention relates to a process for preparing 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen-2-ol compounds useful as an estrogen agonist.... Agent: Pfizer Inc.

20070249026 - Delta 17 desaturases and their use in making polyunsaturated fatty acids: The present invention relates to Δ17 desaturases, which have the ability to convert ω-6 fatty acids into their ω-3 counterparts (i.e., conversion of arachidonic acid [20:4, ARA] to eicosapentaenoic acid [20:5, EPA]). Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ17 desaturases along with a method of... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070249028 - Aerobic succinate production in bacteria: Methods of increasing yields of succinate using aerobic culture methods and a multi-mutant E. coli strain are provided. Also provided is a mutant strain of E. coli that produces high amounts of succinic acid.... Agent: Baker & Mckenzie LLP

20070249027 - Process for producing poly-beta-hydroxybutyrate: A process for producing poly-β-hydroxybutyrate (PHB) involves contacting maple sap with bacteria (e.g Alcaligenes latus) that convert sugars into poly-β-hydroxybutyrate. The use of maple sap is comparable to or better than the use of pure sucrose, and the use of maple sap results in PHB having higher weight average molecular... Agent: National Research Council Of Canada 1200 Montreal Road

20070249030 - Methods, apparatus, products and compositions useful for processing fermentation waste streams: A method for processing a stream from a fermentation process, wherein the stream comprises polysaccharides, the method comprising, contacting the stream with an enzyme to convert at least a portion of the polysaccharides into a fermentable sugar to form a fermentable sugar stream.... Agent: Gilbreth & Associates, P.C.

20070249029 - Self-sustaining and continuous system and method of anaerobically digesting ethanol stillage: A system and method of anaerobically digesting ethanol stillage and reintegrating substantially all by-products thereof back into the system is disclosed. The system includes an ethanol producing facility for producing ethanol and an anaerobic digestion facility for anaerobically digesting stillage from the ethanol producing facility to produce a plurality of... Agent: Antony C. Edwards

20070249031 - Aminopyrimidines useful as kinase inhibitors: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.... Agent: Covington & Burling, LLP Attn: Patent Docketing

20070249032 - Flavivirus vaccine: Replicon virus-like particles can be used as flavivirus vaccines.... Agent: Bell, Boyd, & Lloyd LLP

20070249033 - Methods of terminal sterilization of biological products: The invention relates to methods of sterilizing biologically active products, particularly therapeutic or prophylactic products and the compositions obtained thereby. The methods include obtaining a dried sample containing an amount of trehalose sufficient to render heat stability to the product and exposing the dried sample to heating conditions at a... Agent: Morrison & Foerster LLP

20070249034 - Surfactant biocatalyst for remediation of recalcitrant organics and heavy metals: Novel strains of isolated and purified bacteria have been identified which have the ability to degrade petroleum hydrocarbons including a variety of PAHs. Several isolates also exhibit the ability to produce a biosurfactant. The combination of the biosurfactant-producing ability along with the ability to degrade PAHs enhances the efficiency with... Agent: J. Bennett Mullinax, LLC

20070249035 - Surfactant biocatalyst for remediation of recalcitrant organics and heavy metals: Novel strains of isolated and purified bacteria have been identified which have the ability to degrade petroleum hydrocarbons including a variety of PAHs. Several isolates also exhibit the ability to produce a biosurfactant. The combination of the biosurfactant-producing ability along with the ability to degrade PAHs enhances the efficiency with... Agent: J. Bennett Mullinax, LLC

20070249036 - Apparatus for high-throughput electroporation: An electroporator for high-throughput electroporation is constructed with a well plate in which each well has internal electrodes that extend beyond the opening of the well to form contact areas, either as horizontal platforms extending laterally from the well rims or as extended heights of thin electrode plates. The electroporator... Agent: Townsend And Townsend And Crew, LLP

20070249038 - Microfluidic device for single cell targeted operations: Here we describe an integrated microfluidic chip for delivery of fluids inside or in proximity of individual cells or for measurement of physical quantities. In this device, a cell suspension is pumped through a microchannel in which cells are lined up, pushed on a static microneedle or micropipette, and then... Agent: Andrea Adamo

20070249037 - Monitoring of vitamin k nutritional status: Disclosed herein is a diagnostic apparatus for determining the level of certain nutrients in a body fluid sample, which are used by clinicians to assess proper dosages of anticoagulants, such as coumarin. Specifically exemplified is a diagnostic apparatus that determines a patient's vitamin K nutritional status by determining the level... Agent: Beusse Wolter Sanks Mora & Maire

20070249039 - Minute creature detection system and analytic chip: It is an object of the present invention to shorten the operation time from sampling through to genetic test, and enable the detection of a minute creature with good accuracy. Provided is minute creature detection system in which treatments from gene extraction to detection of are conducted on an analytic... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070249040 - Simple portable bacteria detector: A portable bacteria detector not only simply capable of inspecting the presence of food-poisoning bacteria and the like but also provided with a disinfecting or sterilizing means itself has been widely used. As its application fields spread, the detector has been required to be more inexpensive and be constituted in... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070249041 - Cell co-culture apparatus for researching cell interaction and method thereof: A cell co-culture apparatus and a method of co-culturing and isolating cells using the cell co-culture apparatus to research interactions between cells by direct contact between the cells are provided. The cell co-culture apparatus includes a first substrate including a substrate portion and a plurality of projections provided on a... Agent: Cantor Colburn, LLP

20070249043 - Adenoviral expression vectors: The present invention provides a recombinant adenovirus vector characterized by the partial or total deletion of adenoviral E2B function and having an expression cassette containing a heterologous sequence encoding a protein of interest inserted into the E1 region. Such vectors are designed to reduce or eliminate the occurrence of replication... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070249042 - Strains of e. coli for plasmid dna production: A general method and strains of bacteria are described, by means of which it is possible to dramatically purify plasmid DNA with respect to genomic DNA, and RNA. In one preferred embodiment, lysis and nuclease removal of host nucleic acids is an integral component of the fermentation/harvest process, and as... Agent: Brooks Kushman P.C.

20070249045 - Adipose derived adult stem cells in hepatic regeneration: The present invention provides a method to derive hepatic stem cells from stem cells derived from non-liver tissue. In one embodiment of the invention, hepatic stem cells are derived from adipose stem cells. The invention also provides a method of enhancing hepatic cytokine production (e.g., HGF) from ASCs, which may... Agent: Foley And Lardner LLP Suite 500

20070249044 - Microstructures in three dimensional gel suspensions for growth of cells: The present invention provides a three-dimensional cell culture system for the growth of cells and the method of making the same.... Agent: Marshall, Gerstein & Borun LLP

20070249046 - Apparatus and method for the static application of therapeutic ultrasound and stem cell therapy of living tissues: Devices and methods for treating tissue injuries and augmenting the maturation and differentiation of stem cell populations are provided. The devices comprises ultrasonic oscillators capable of variable frequency output, user-selectable based on the tissue being treated. The devices produce therapeutic ultrasound that is pulsed and has a modulated amplitude and... Agent: Seed Intellectual Property Law Group PLLC

20070249047 - Differentiation of multi-lineage progenitor cells to respiratory epithelial cells: Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described, as well as methods of differentiating the progenitor cells into type II alveolar cells.... Agent: Fish & Richardson P.C.

20070249049 - 6-modified bicyclic nucleic acid analogs: The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.... Agent: Schwegman, Lundberg & Woessner/isis

20070249050 - Substituted aromatic compounds for inflammation and immune-related uses: e

20070249048 - Triptolide 5,6-derivatives as immunomodulators and anticancer agents: Compounds useful as immunosuppressive, anti-inflammatory and anticancer agents and methods of their preparation and use are described. The compounds are analogs or derivatives of triptolide and related compounds, modified at the 5- and/or 6-position relative to the naturally occurring compounds.... Agent: Perkins Coie LLP

20070249051 - Vinyl-phenyl derivatives for inflammation and immune-related uses: m

20070249052 - Cartilage regeneration by generation of chondrons under high concentrations of magnesium: The present invention relates to a method for the generation of chondrons and of cartilaginous tissue. In particular, the present invention relates to the ability of Mg ions to stimulate the growth and regeneration of chondrons, particularly of pseudo-chondrons as an intermediate in the regeneration and growth of cartilaginous tissue.... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070243522 - Inspection chip for biological material: There is provided an inspection chip capable of performing a number of solution feeding processes promptly and accurately. The inspection chip has one continuous flow path comprising a reaction flow path for accommodating a plurality of beads with immobilized probes of types different each other, a first and second solution... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070243521 - Method and apparatus for the non-invasive measurement of tissue function and metabolism by determination of steady-state fluorescence anisotropy: A non-invasive measurement of biological tissue reveals information about the function of that tissue. Polarized light is directed onto the tissue, stimulating the emission of fluorescence, due to one or more endogenous fluorophors in the tissue. Fluorescence anisotropy is then calculated. Such measurements of fluorescence anisotropy are then used to... Agent: William H. Eilberg

20070243550 - Molecular detection and quantification of enterococci: A primer pair and probe for the large subunit ribosomal RNA gene of enterococci for use in a real-time nucleic acid sequence based amplification (NASBA) assay.... Agent: Smith Hopen, Pa

20070243559 - Immunoassay method: An immunoassay method including the steps of: preparing a measuring sample by mixing a specimen with an immunoreactive substance, capable of specifically binding to a defined analyte, allowing the sample to react for a given reaction time, measuring a signal related to interactions of the immunoreactive substance with the analyte... Agent: Rankin, Hill, Porter & Clark LLP

20070243567 - Beta cell mimicking control algorithm for artificial pancreas: The invention is a method of controlling an artificial pancreas. The method includes reading and recording a current plasma glucose level. The method includes computing glucose in beta cell if a current plasma glucose level is greater than a threshold value, and continuing the step of reading and recording a... Agent: Law Offices Of Clement Cheng

20070243578 - Method, system, apparatus and kit for semen analysis: The present invention is generally directed towards a method, system, apparatus and/or kit for collecting samples of bodily fluids, and more specifically towards collection of supplies that enable a lay person to collect and analyze a semen sample for use at home for male fertility or in the animal husbandry... Agent: Kevin Lynn Wildenstein

20070243584 - Tetramerizing polypeptides and methods of use: The present invention relates to a method of preparing a tetrameric protein comprising culturing a host cell transformed or transfected with an expression vector encoding a fusion protein comprising a vasodialator-stimulated phosphoprotein (VASP) domain and a heterologous protein. In one embodiment, the heterologous protein is a membrane protein, the portion... Agent: Zymogenetics, Inc. Intellectual Property Department

20070243518 - Continuous cardiac perfusion preservation with peg-hb for improved hypothermic storage: Efforts to extend myocardial preservation for transplantation by perfusion with prior crystalloid based solutions have been limited by edema and compromised function. Hypothermic perfusion preservation with a polyethylene glycol (PEG) conjugated hemoglobin solution extends preservation times. The polyethylene glycol (PEG) conjugated hemoglobin solution comprises PEG-Hb, and at least one of... Agent: Stout, Uxa, Buyan & Mullins LLP

20070243520 - Method for screening an agent for preventing or ameliorating wrinkles: There is provided a screening method which can select a photoaging-preventing or improving agent or a wrinkle-preventing or improving agent with efficiency and reliability. The screening method for a photoaging- or wrinkle-preventing or improving agent selects, as a candidate, a substance inhibiting the expression of keratin 6 and/or keratin 16... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070243523 - Methods and apparatus for the manipulation of particle suspensions and testing thereof: Apparatus and methods are provided for analysis of individual particles in a microfluidic device. The methods involve the immobilization of an array of particles in suspension and the application of experimental compounds. Such methods can also include electrophysiology studies including patch clamp recording, electroporation, or both in the same microfluidic... Agent: Wilson Sonsini Goodrich & Rosati

20070243519 - Protecting group for carboxylic acids that can be photolyzed by visible light: The present invention relates to a photolabile compound including a coumarin family caging group covalently bound to an organic moiety containing a carboxyl group, an amino group, a sulfhydryl group, and/or a hydroxyl group. The photolabile compound, upon absorbing visible light, releases the organic moiety. Also disclosed is a method... Agent: Nixon Peabody LLP - Patent Group

20070243526 - Aav capsid library and aav capsid proteins: Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a library from which the capsids are selected are also provided.... Agent: Perkins Coie LLP

20070243525 - Method and a device for the evaluation of biopolymer fitness: A Method for identifying one or a small number of molecules, especially in a dilution of ≦1 μM, using laser excited FCS with measuring times ≦500 ms and short diffusion paths of the molecules to be analyzed, wherein the measurement is performed in small volume units of preferably ≦10−14 l,... Agent: Jacobson Holman PLLC

20070243524 - Sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents: The present application discloses and claims polynucleic acids relating to and/or containing HCV polynucleic acid sequences.... Agent: Nixon & Vanderhye, PC

20070243546 - Analysis of methylation using nucleic acid arrays: Arrays for genome-wide analysis of methylation are disclosed. In a preferred aspect arrays comprising a plurality of probes complementary to a plurality of identified CpG islands in the human, mouse and rat genome are disclosed. The arrays may be used to detect methylation within CpG islands in samples from human,... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070243553 - Analytical method and kit: Analytical methods using RNA probes for the detection or analysis of nucleic acid sequences is described. These probes are contacted with a sample suspected of containing the nucleic acid sequence and if they form duplexes, they are hydrolysed. This may be done, for example during an amplification reaction. AMP generated... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20070243529 - Aptamer selection method: The present invention provides a method for the selection of aptamer sequences and aptamers identified using the method. The method comprises immobilizing a library oligonucleotide by forming a duplex with an antisense oligonucleotide, reating the duplex molecule with a target and collecting oligonucleotide molecules which dissociate from the duplex structure.... Agent: Occhiuti Rohlicek & Tsao, LLP

20070243551 - Assay system using labeled oligonucleotides: The present invention provides a useful system for assays that comprises a solid support, a plurality of capture oligonucleotides immobilized onto the solid support, and complementary oligonucleotides attached to capture ligands. A detectable label can be directly attached to the capture oligonucleotides or the complementary oligonucleotides. The labeled oligonucleotides can... Agent: Beckman Coulter Inc. C/o Sheldon Mak Rose & Anderson

20070243548 - Calumenin-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance: Methods are disclosed for diagnosing chemotherapeutic drug resistance in neoplastic cells by detecting an increase in the expression of calumenin in such neoplastic cells as compared to the level of expression of calumenin protein in a non-MDR neoplastic cell. In addition, disclosed are methods for treating neoplastic cells, including reversing... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070243541 - Compositions and methods for generating antigen-binding units: The present invention provides non-single-chain antigen-binding units that is stabilized by leucine zipper sequences. The experimental design is particularly useful for generating and screening for Nsc Abus that remain the binding capabilities to their respective antigens within a cell. The present invention also provides recombinant polynucleotides, host cells and kits... Agent: Morgan, Lewis & Bockius LLP (sf)

20070243544 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent: Casimir Jones, S.c.

20070243549 - Enrichment of circulating fetal dna: A non-invasive screening or diagnostic method for determining the likelihood of a fetus with a genetic abnormality or a potential pregnancy complication, which utilizes a liquid blood sample from a pregnant woman. Antibodies specific to a section of histone 3.1 which is exposed to a far greater extent in chromatin... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070243539 - Genetic variants of human inositol polyphosphate-4-phosphatase, type i (inpp4a) useful for prediction and therapy of immunological disorder: Atopic asthma is a chronic, inflammatory lung disease characterized by recurrent breathing problems in response to an allergen. Platelets play an important role in this allergic inflammatory process, by releasing preformed mediators like platelet factor 4 (PF4) and regulated upon activation in normal T cells expressed and secreted (RANTES) upon... Agent: Morgan & Finnegan, L.L.P.

20070243537 - Human sample matching system: Methods and apparatus for a collecting a human odor or DNA sample (S), analyzing the sample (S) and then determining a good romantic match is disclosed. In one embodiment, a customer purchases an AromaMatch™ Test Kit (14), which comprises a bottle of cleaning solution (20), a cotton ball (22) a... Agent: Giaccherini

20070243540 - Kits and methods for identification, assessment, prevention and therapy of breast cancer: Disclosed herein are methods for detecting and identifying potential breast cancer biomarkers in an individual patient. Also disclosed are newly discovered breast cancer markers set forth in Tables I, II and III, associated with the cancerous state of breast cells. It has been discovered that a higher than normal level... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20070243545 - Method for combining immunostaining and fish using covalently binding fluorophores: Among embodiments is disclosed a process for immunostaining a sample such that the stain is stable under FISH conditions... Agent: Kelley Drye & Warren LLP

20070243543 - Method for isolation of transcription termination sequences: The invention relates to efficient, high-throughput methods, systems, and DNA constructs for identification and isolation of transcription termination sequences. The invention relates further to specific terminator sequences identified by said methods isolated from rice.... Agent: Connolly Bove Lodge & Hutz, LLP

20070243528 - Methods for detecting polymorphisms using arms or rflp: The invention provides a method for the detection of a polymorphism in OATP8 in a human. The method for detection of a nucleic acid polymorphism is selected from amplification refractory mutation system and restriction fragment length polymorphism. The invention also provides use of the method to assess the pharmacogenetics of... Agent: Fish & Richardson P.C.

20070243538 - Methods for identification of alport syndrome: Animals with mutations in COL4α4 present with autosomal recessive Alport Syndrome (ARAS). Through sequencing of COL4α4, the mutation causative for ARAS in the English Cocker Spaniel (ECS) has been identified. The resulting protein is severely truncated due to a premature stop codon in exon 3. This nonsense mutation occurs in... Agent: Patrea L. Pabst Pabst Patent Group LLP

20070243536 - Methods for identifying novel pesticidal gene homologues: Methods and compositions for identifying novel pesticidal gene homologues are provided. Specifically, the methods of the invention comprise systematically designing oligonucleotide primers that are specific for a pesticidal gene of interest and performing successive rounds of PCR amplification of nucleic acid material from a microorganism, particularly a Bacillus thuringiensis strain,... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20070243535 - Methods for increasing accuracy of nucleic acid sequencing: The invention provides methods for improving the accuracy of a sequencing-by-synthesis reaction by sequencing at least a portion of a template and at least a portion of template complementary sequence.... Agent: Edwards Angell Palmer & Dodge LLP

20070243531 - Methods of diagnosing colorectal cancer and reagents therefor: The present invention relates to assays for diagnosing colorectal cancer or a predisposition therefore or the neoplastic potential of a colorectal polyp wherein hypermethylation of an MCC gene promoter is determined. The invention provides various multi-analyte diagnostic tests and reagents for performing these diagnostic/predictive assays.... Agent: Bozicevic, Field & Francis LLP

20070243552 - Novel approach to molecular diagnosis of human papillomavirus-related diseases: The present invention relates to an accurate, sensitive, and efficient sequential or concurrently sequential method for molecular diagnosis of human papillomavirus (HPV)-based disease, where the method improves the accuracy and reliability of diagnostic and prognostic assessments of HPV-based disease. The method of the invention comprises a primary screen of a... Agent: Morgan & Finnegan, L.L.P.

20070243530 - Nucleic acid probes and broad-range primers from regions in dna directed rna polymerase subunit b genes, and methods in which they are used: The invention relates to nucleic acid probes and to broad-range primers that are useful in the identification of bacterial species and the diagnosis of bacterial infections. Especially, the invention relates to specific nucleic acid probes that originate from hyper-variable regions situated near the conserved sequences of the gene for RNA... Agent: Buchanan, Ingersoll & Rooney PC

20070243534 - Probe density considerations and elongation of self-complementary looped probes where probes are attached to a solid phase: In a multiplexed assay method carried out in solution, wherein the solution contains nucleic acid targets and, wherein several different types of oligonucleotide probes, each type having a different sequence in a region designated as a target binding domain, are used to detect the nucleic acid targets, said assay method... Agent: Eric P. Mirabez

20070243533 - Products and methods of organism identification in nutritional supplements: Certain plant species are used as nutritional or dietary supplements. Several specific regions within these supplements have been identified as particularly useful sources of diagnostic DNA sequences. These regions are found in the nuclear genome, the chloroplast genome and the mitochondrial genome. The sequences can be used to design nucleic... Agent: Kile Goekjian Reed & Mcmanus

20070243542 - Rapid and efficient capture of dna from sample without using cell lysing reagent: Nucleic acids can be made available for amplification or other treatment after admixture of a sample with specific weakly basic polymers to form a precipitate with the nucleic acids at acidic pH. After removing non-precipitated materials, the pH is then made basic, thereby releasing the nucleic acids from the polymer.... Agent: Philip S. Johnson Johnson & Johnson

20070243527 - Rigidized trimethine cyanine dyes: c

20070243532 - System and method of detecting a microorganism: A system for detecting the presence or absence of microorganisms in various types of samples is described. A process for detecting the presence or absence of microorganisms in samples is also described.... Agent: Cognis Corporation Patent Department

20070243547 - Use of tumor susceptibilty gene 101 (tsg 101) as a prognostic and diagnostic marker: The present invention discloses the link between oncogenic Ras and TSG101 and the negative effect of TSG101 on the expression of p21 in ovarian cancer. The present also discloses the use of TSG101 as a prognostic, diagnostic marker and a potential therapeutic target in cancer, especially ovarian cancer.... Agent: Benjamin Aaron Adler Adler & Associates

20070243554 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070243560 - Method for examining kidney diseases: Method for examining kidney disease, which comprises detecting fatty acid binding protein derived from kidney tissues, which is present in specimen collected from mammal excluding Rodents. By the present method, it is possible to obtain test results which may be very important information for diagnosis of prognosis of kidney disease,... Agent: Birch Stewart Kolasch & Birch

20070243555 - Method of detecting the cystic fibrosis transmembrane conductance regulator (cftr) at cell exterior: The present invention provides a recombinant nucleic acid encoding a modified cystic fibrosis transmembrane conductance regulator (CFTR) protein. The nucleic acid is modified by the insertion of a first heterologous segment encoding a detectable epitope in a region encoding an extracytoplasmic loop, such as at least one of EL1 through... Agent: Myers Bigel Sibley & Sajovec

20070243558 - Peptide stabilization: The present invention is directed to the use of DMSO for the stabilization of temperature sensitive proteins and peptides, such as gastrin, against degradation in a mammalian biological sample, such as a serum or plasma sample.... Agent: Birch Stewart Kolasch & Birch

20070243557 - Rapid tuberculosis detection method: Methods for diagnosing Mycobacterium tuberculosis infection in a human that include providing blood serum, contacting the serum with an Eis antigen fixed on a substrate, thereby forming complexes of Eis antigen with a human antibody that binds to the Eis antigen, contacting the antibody/Eis complexes with a labeled anti-human secondary... Agent: Quarles & Brady LLP

20070243556 - Smart combinatorial operando spectroscopy catalytic system: A device and combinatorial method is disclosed for screening a plurality of catalytic materials simultaneously while determining the dynamic bulk and surface nature of the catalytic materials being screened under reaction conditions and surface chemical kinetic and mechanistic information for determining the structure-activity/selectivity relationship of the catalytic materials, and for... Agent: Banner & Witcoff

20070243563 - Aflatoxin-albumin adduct measurement and the uses thereof: The invention discloses one immunoassay for aflatoxin-albumin adducts measurement in serum. In Particular, serum pretreatments including albumin precipitation, resuspension, dialysis, albumin digestion, enzyme precipitation and aflatoxin extraction, centrifugation and resuspension are unnecessary, which is convenient for clinical routine serum testing. The invention also discloses their clinical uses in rapid measurement... Agent: Apex Juris, PLLC Tracy M Heims

20070243564 - Identification of antibody-producing cells: The present invention provides an automated homogeneous assay for identifying an antibody-producing cell producing an antibody which binds to a selected antigen, especially a high yielding antibody-producing cell.... Agent: Woodcock Washburn LLP

20070243565 - Luminescence resonance energy transfer (lret) assays for clostridial toxin activity: Clostridial toxin substrates comprising a lanthanide donor complex, an acceptor, and a Clostridial toxin recognition sequence including a cleavage site; methods for determining the activity of a Clostridial toxin from a test sample using such Clostridial toxin substrates; cell compositions comprising such Clostridial toxin substrates and a Clostridial toxin receptor;... Agent: Dean G. Stathakis (t2-7h) Allergan, Inc.

20070243561 - Prognostic markers in chronic lymphocytic leukemia: Methods and compositions for detecting a form of chronic lymphocytic leukemia in a subject are described which allow for distinguishing more aggressive forms of the disease from less aggressive forms. Particularly described methods include assaying a sample obtained from the subject having or suspected of having chronic lymphocytic leukemia for... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20070243562 - Lectins for analyzing sugar chains and method of using the same: It is expected that lectins of a needed number of types appropriately corresponding the variation of sugar chains, if available, are highly useful as tools for analyzing various sugar chains. From a lectin library containing plural types of lectins or an arbitrary mass of lectins containing plural types of lectins,... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070243566 - Genetically engineered pyrroloquinoline quinone dependent glucose dehydrogenase comprising an amino acid insertion: The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and 429 as corresponding to the amino acid sequence known from Acinetobacter calcoaceticus, to genes encoding such variant s-GDH, to proteins of such s-GDH variants with improved... Agent: Barnes & Thornburg LLP (roche)

20070243569 - Protein kinase-inducible domains: Applicants have used protein design to develop novel functional protein architectures, termed protein kinase-inducible domains, whose structures are dependent on phosphorylation by specific protein kinases or are dependent on dephosphorylation by specific protein phosphatases. Applicants have designed kinase-inducible domains based on a modular architecture, which allows kinase-inducible domains to be... Agent: Potter Anderson & Corroon LLP Attn: Kathleen W. Geiger, Esq.

20070243568 - Specific substrates for o6-alkylguanine-dna alkyltransferase: The invention relates to substrates for O6-alkylguanine-DNA alkyltransferases (AGT) of formula R1-A-X—CH2—R3—R4-L1, wherein A is a group recognized by AGT as a substrate, X is oxygen or sulfur, R1 is a group —R2-L2 or a group R5, R2 and R4 are, independently of each other, a linker, R3 is an... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070243570 - Apoptosis inducer for cancer cell: The present invention revealed that by suppressing the expression of the WRN gene, the BLM gene, or the RecQ1 gene, which belong to the RecQ helicase family, apoptosis is induced in various cancer cells and their proliferation is suppressed. Compounds that suppress the expression of RecQ helicase family genes or... Agent: Seed Intellectual Property Law Group PLLC

20070243571 - Method for measurement of activity of homocysteinethiolactone hydrolyzing enzyme: Disclosed is a method for measurement of the activity of the homocysteinethiolactone hydrolyzing enzyme in a sample, which method comprises mixing and reacting γ-thiobutyrolactone and the sample in the presence of a cholinesterase inhibitor, and measuring 4-mercaptobutyric acid thereby produced. The method is safe and easy in operation, for it... Agent: Millen, White, Zelano & Branigan, P.C.

20070243575 - Compositions and methods for treatment of immune-related disease: The invention provides methods for identifying novel agents for modulating the immune system or compounds useful for modulating immune responses. Also provided are compositions and methods for preventing or treating immune-related diseases, infectious diseases, or neoplastic diseases in mammalian subjects. Pharmaceutical compositions are provided for treating such diseases.... Agent: The Scripps Research Institute

20070243572 - Interacting microhabitat array and uses thereof: The invention is directed to an interacting microhabitat array for microorganisms having more than one microhabitat in a substrate in which at least two microhabitats are connected in series by at least one corridor. The corridor is of sufficient size to allow the microorganism to move between microhabitats in a... Agent: Connolly Bove Lodge & Hutz, LLP

20070243573 - Method and apparatus for immobilizing cells, and cell-immobilized substrate: A method and apparatus for efficiently immobilizing cells on a substrate without damaging the cells, and a cell-immobilized substrate is provided. Cells 4a contacting a substrate 2 is irradiated with light 10 which includes light having a wavelength of 330 to 410 nm, thereby adhering cells 4a to the substrate... Agent: Ostrolenk Faber Gerb & Soffen

20070243576 - Method to confirm immunosuppression in human patients by measuring lymphocyte activation: Methods for measuring the function of lymphocytes and their responses to mitogens or specific antigens, with or without co-stimulatory agents, is provided. The methods are suitable for measurement of the responses of lymphoid cells when they are a subpopulation of cells, and also for measuring the function of specific subsets... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070243574 - Vascular mimic for drug and device evaluation: The present invention provides tissue engineered vascular grafts (TEVGs) and Blood Vessel Mimics (BVMs) and methods for using TEVGs as BVMs in in vitro model systems for the evaluation of intravascular devices and drugs. The present invention additionally relates to devices and methods for preparing TEVGs, BVMs and BVM model... Agent: Thelen Reid Brown Raysman & Steiner LLP

20070243577 - Method for the detection of apoptosis by determining apoptosis-specific markers released into an extracellular medium through cellular release mechanisms: A method for the detection of apoptosis by determining presence, amount, or activity of apoptosis-specific markers released from at least one cell undergoing apoptosis into an extracellular medium through cellular release mechanisms is disclosed. The extracellular medium includes body fluids, in particular urine, inflammatory fluid, serum, liquor, or cell culture... Agent: Jacobson Holman PLLC

20070243583 - Artificial disulfide isomerases and uses thereof: The present invention provides artificial enzymes comprising, e.g., an N-terminal domain derived from E. coli FkpA that allows for dimerization and provides a substrate binding region, and a C-terminal thioredoxin domain derived from E. coli DsbA. Similar to DsbC, such de novo designed chimeric (hybrid) FkpA-DsbA enzymes function, as disulfide... Agent: Fulbright & Jaworski L.L.P.

20070243580 - Basb019 proteins and genes from moraxella catarrhalis, antigens, antibodies, and uses: The invention provides BASB019 polypeptides and polynucleotides encoding BASB019 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.... Agent: Dechert LLP

20070243586 - Novel organic anion transport proteins: The current invention discloses nucleic acid and amino acid sequences for novel organic anion transfer proteins (“OATPs”). The invention encompasses the OATPs described herein, together with vectors containing the cDNA sequences, host cells containing the vectors and polypeptides having all or part of an OATP. Also encompasses are uses for... Agent: Louis J. Wille Bristol-myers Squibb Company

20070243585 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070243581 - Process for producing dipeptides: The present invention provides: a protein having dipeptide-synthesizing activity or a protein for dipeptide synthesis; DNA encoding the protein having dipeptide-synthesizing activity or the protein for dipeptide synthesis; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein having dipeptide-synthesizing activity; an... Agent: Fitzpatrick Cella Harper & Scinto

20070243582 - Process for producing protein a-like protein with use of brevibacillus genus bacterium: The present invention relates to an efficient and economical process for producing a protein A-like protein. Hosts such as Escherichia coli and Bacillus subtilis have been used in the production of a protein A-like protein using a genetic recombination technique and however, their low productivity has been a big cause... Agent: Sughrue Mion, PLLC

20070243579 - Selection markers useful for heterologous protein expression: Selection markers in prior art systems are based on resistance genes or on complementation of auxotrophic mutations. The requirement for expression of these markers is conditional e.g. on the presence of an antibiotic, or on the absence of a nutrient. In contrast, the selection markers used in this invention arc... Agent: Arent Fox PLLC

20070243587 - Using a reverse genetic engineering platform to produce protein vaccines and protein vaccine of avian influenza virus: The present invention relates to a preparation method of protein vaccines, and comprises the steps of: (a) providing at least one amino acid sequence of an epitope of a target antigen protein; (b) converting the amino acid sequence into a nucleic acid sequence and modifying the codons; (c) synthesising a... Agent: Bacon & Thomas, PLLC

20070243589 - Antibodies against human il-22 and uses therefor: The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22 activity, thereby modulating immune responses in general, and those mediated by IL-22 in particular. The disclosed compositions and methods may be used for... Agent: Wyeth/finnegan Henderson, LLP

20070243588 - Factor vii or viia - like molecules: Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates are provided. Methods of treatment by administering a FVII or FVIIa conjugate are provided.... Agent: Maxygen, Inc. Intellectual Property Department

20070243590 - Method for producing basic substance: A method for producing a basic substance by fermentation comprising culturing a microorganism having an ability to produce the basic substance in a liquid medium contained in a fermentation tank to produce and accumulate the basic substance in the medium, wherein amount of sulfate and/or chloride ions used as counter... Agent: Cermak & Kenealy LLP Acs LLC

20070243591 - Enzymatic modification in a continuously regenerated packed bed column: A process for the modification of a substrate comprising passing the substrate through a packed bed column of a specific volume of immobilized enzyme wherein the substrate enters the column at or near one end of the column (the ‘inlet end’) and the modified substrate exits at or near the... Agent: The Webb Law Firm, P.C.

20070243592 - Compositions and methods for producing fermentation products and residuals: The present invention provides compositions and methods designed to increase value output of a fermentation reaction. In particular, the present invention provides a business method of increasing value output of a fermentation plant. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the... Agent: Wilson Sonsini Goodrich & Rosati

20070243593 - Detection and amplification of ligands: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an... Agent: Hahn Loeser & Parks, LLP

20070243594 - Oxidoreductase from pichia capsulata: The invention relates to a NADH-dependent oxidoreductase obtained from yeasts, for example, of the genus Pichia, more particularly from Pichia capsulata. The oxidoreductace used in an enzymatic process for enantioselective reduction of organic ketocompounds to the corresponding (S)-hydroxy compounds and in an enzymnatic process for anantioselective preparation of (S)-hydroxy compounds... Agent: Lowe Hauptman Ham & Berner, LLP

20070243595 - Modified enzymes, methods to produce modified enzymes and uses thereof: The invention is directed to modified xylanases having increased stability in harsh industrial environments, such as increased pH and/or temperature.... Agent: Genencor International, Inc. Attention: Legal Department

20070243596 - Simultaneous desizing and scouring process: The present invention relates to a process for simultaneously desizing and scouring of sized fabric containing starch or starch derivatives, which process comprises treating fabric with an alkaline alpha-amylase and an alkaline scouring enzyme. The invention also relates to a composition comprising an alkaline alpha-amylase and an alkaline scouring enzyme.... Agent: Novozymes North America, Inc.

20070243597 - Disinfectant solutions: Embodiments disclosed herein relate to improved disinfectant solutions. In certain examples, the disinfectant solutions may be used to kill micro-organisms such as bacteria and viruses, for cleaning medical apparatus or for disinfecting other devices.... Agent: Lowrie, Lando & Anastasi

20070243598 - Novel pseudonocardia sp. rmrc pah4 and a process for bioconverting compactin into pravastatin using the same: The invention provides a novel microorganism Pseudonocardia sp. RMRC PAH4 characterized in that it is able to degrade high concentration of quinoline by enrichment culture, shows a high tolerance to compactin-sodium and possesses a high hydroxylation activity of converting compactin-sodium to pravastatin-sodium. The invention relates also a process for converting... Agent: Brown & Michaels, PC 400 M & T Bank Building

20070243599 - Method for determining the phenotype of cells: The present invention provides a system, a device, and a kit for comparing the phenotypic state of a first unknown sample material with a sample material of a known phenotypic state. The present invention also provides a method of using the system, device and kit.... Agent: Philip S. Johnson Johnson & Johnson

20070243600 - System for performing multi-formatted assays: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a... Agent: Gen Probe Incorporated

20070243601 - Method for stabilizing assay reagents, reagent container with stabilized assay reagents and use thereof: This invention relates to a reagent container for detection and/or quantitation of at least one biological or chemical analyte from a sample, said reagent container comprising an inner surface enclosing a volume, wherein volume analytical reactions of at least one analysis for detection and/or quantitation of at least one analyte... Agent: James C. Lydon

20070243602 - Immobilized biocatalytic enzymes in electrodeionization (edi): A porous solid ion exchange wafer having a combination of a biomolecule capture-resin and an ion-exchange resin forming a charged capture resin within said wafer. Also disclosed is a porous solid ion exchange wafer having a combination of a biomolecule capture-resin and an ion-exchange resin forming a charged capture resin... Agent: Harry M. Levy, Esq. Olson & Hierl, Ltd

20070243603 - Platform: The invention relates to a platform (1) for a device for wetting objects, especially for an incubation/hybridization chamber that is defined by an object support (57) and the platform (1) arranged at a distance to said object support (57). Said platform comprises a base (3) provided with at least one... Agent: Harness, Dickey & Pierce, P.L.C

20070243604 - Marker for selecting transformant with the use of lethal gene: A DNA fragment prepared by inserting a translation termination codon into 5′ upstream side of the active site of a lethal gene, a transformant selection marker which uses the same, and a vector into which the marker is inserted. Since this lethal gene is used as a gene marker, complete... Agent: Morgan Lewis & Bockius LLP

20070243605 - Ribonucleases and methods of making them recombinantly: Methods for recombinantly producing new RNases, as well as previously-known RNases, are disclosed. The new RNases are active against human carcinoma cells.... Agent: Mark H. Jay, P.A.

20070243606 - Ribonucleases and methods of them recombinantly: Methods for recombinantly producing new RNases, as well as previously-known RNases, are disclosed. The new RNases are active against human carcinoma cells.... Agent: Mark H. Jay, P.A.

20070243608 - Platelet bioreactor: Platelets are produced in a bioreactor in which hematopoietic stem cells (HSCs) are cultured to produce megakaryoctye progenitors, megakaryocytes, and platelets. The HSCs are stably genetically engineered to express HoxA2 or HoxB2 which induces HSC proliferation and promotes generation of megakaryocytes.... Agent: Richard Aron Osman

20070243607 - Polymeric microcarriers for cell culture functions: Polymeric microcarriers suitable for use in cell culture processes and the methods of making such polymeric microcarriers by emulsion/aggregation polymerization processes.... Agent: Oliff & Berridge, PLC.

20070243609 - Cell populations which co-express cd49c and cd90: Substantially homogenous cells populations which co-express CD49c, CD90 and telomerase are made. In one embodiment, humans suffering from a degenerative, traumatic, acute injury, cardiac or neurological condition are treated with the substantially homogenous cells populations which co-express CD49c, CD90 and telomerase. In another embodiment, committed progenitor cells are made are... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070243610 - Embryonic stem cell line and method for preparing the same: An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.... Agent: Dickstein Shapiro LLP

20070243611 - Wt1 interacting protein wtip: A human WT1 interacting protein (WTIP) having the amino acid sequence as set forth in SEQ ID NO: 2 or a gene encoding it.... Agent: Foley And Lardner LLP Suite 500

20070243612 - Novel compounds for modulating cell proliferation: Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070243613 - Method for producing a cell culture substrate: A main object of the invention is to provide a new method for producing a cell culture substrate used to cause cells to adhere in a highly precise form onto a base material and then culture the cells. To attain the object, the invention provides a method for producing a... Agent: Seyfarth Shaw LLP

20070243614 - Bacillus thuringiensis cry gene and protein: Compositions and methods for protecting a plant from an insect pest are provided. In particular, novel polynucleotides and the pesticidal polypeptides they encode are provided. Methods of using the novel polynucleotides and pesticidal polypeptides of the invention to protect a plant from an insect pest are further provided. Particular embodiments... Agent: Pioneer Hi-bred International, Inc.

20070243615 - Methods for producing preparations of recombinant aav virions substantially free of empty capsids: Methods for separating AAV empty capsids from mixtures of AAV vector particles and AAV empty capsids are described. The methods use column chromatography techniques and provide for commercially viable levels of recombinant AAV virions.... Agent: Robins & Pasternak

20070243616 - In vivo alteration of cellular dna: The present invention relates to methods, cells and compositions for performing in vivo recombination without the need for clonal selection. These methods, cells and compositions are useful for the automation of recombination. The present invention provides methods for performing sequential steps in genome engineering, as well as for achieving parallel... Agent: Banner & Witcoff, Ltd.

20070243617 - Modular genomes for synthetic biology and metabolic engineering: The invention provides methods and compositions for assembling a modular replacement genome in a host microorganism. After such assembly, the host organism's genome is inactivated or ablated to permit full control of host cellular functions by the replacement genome. A modular replacement genome comprises an assembly of nucleic acid fragments,... Agent: Stephen C. Macevicz Technology Development Office

20070238089 - Particle patterning chip: This invention provides devices comprising substrates with wells for the patterning of particles or cells. Such devices are loaded with a suspension of particles or cell, and the entrapped particles or cells are transferred to a second substrate, where patterning of individual particles or cells occurs. Methods of cellular analysis,... Agent: Pearl Cohen Zedek Latzer, LLP

20070238090 - Systems and methods for effecting a physical change in a biological sample: The present invention relates generally to systems and methods for processing a biological sample that result in a physical change, such as reacting two molecules together to form a reaction product or for use in lysing viruses or biological cells for analysis using biological assay systems. As such, the present... Agent: Jeffrey H. Rosedale, Esquire Woodcock Washburn LLP

20070238095 - Detection of influenza a virus: The invention provides methods to detect influenza A in biological samples using real-time PCR. Primers and probes for the detection of influenza A are provided by the invention. Articles of manufacture containing such primers and probes for detecting influenza A are further provided by the invention.... Agent: Fish & Richardson P.C.

20070238097 - Method used to survey for presence of avian antibodies which reflect exposure to an immunogen: A method to survey for activity of avian borne infections using an Avian Egg Vector Immuno Surveillance System. The method includes eggs collected from sentinel flocks in a desired area of surveillance. IgY, IgM and IgA antibodies are separated from the eggs. Separated antibodies are analyzed using an immuno assay... Agent: Mark A Koch

20070238104 - Competitive oligonucleotides: The present invention generally relates to competitive oligonucleotides and, in some embodiments, to competitive oligonucleotides for use in comparative genomic hybridization (CGH) and related techniques. One aspect is generally directed to a blocking composition constructed and arranged to be used in an assay of a nucleic acid. The blocking composition... Agent: Agilent Technologies Inc.

20070238103 - Genetic markers for prognosis of antifolate treatment efficacy: Methods and kits for predicting the efficacy of antifolate (e.g., methotrexate) treatment of rheumatoid arthritis by detecting polymorphisms, particularly single nucleotide polymorphisms, in adenosine pathway genes.... Agent: Young & Thompson

20070238114 - Method and apparatus for disrupting cells and purifying nucleic acid using a single chip: Provided herein is a method and apparatus for disrupting cells and purifying nucleic acids in a single chip. The method comprises irradiating a chip with a laser beam, wherein the chip comprises a solid support on which a cell lysis enhancing metal oxide layer, and a cell binding metal oxide... Agent: Cantor Colburn, LLP

20070238109 - Method and apparatus for purifying nucleic acid on hydrophilic surface of solid support using hydrogen bonding: Provided is a method of purifying nucleic acid, the method including: contacting a nucleic acid-containing sample and a solution containing a kosmotropic salt on a solid support having a hydrophilic functional group on its surface to bind the nucleic acid to the solid support. Since the solid support is used... Agent: Cantor Colburn, LLP

20070238107 - Method of assessing dna mutability: The present invention relates to a method and a kit for assessing mutability of a DNA sequence of interest. The method involves using a mutation hotspot sequence as a standard to determine whether the DNA sequence of interest is more or less mutable than the hotspot sequence. The mutation events... Agent: Quarles & Brady LLP

20070238121 - Methods and apparatuses for comparative genomic microarray analysis: Control nucleic acids and their method of use to simultaneously test for numerous genetic alterations that involve an unbalanced arrangement of chromosomes. One implementation increases reliability and accuracy by adding additional nucleic acid to test and/or reference samples. Clones representing segments insensitive to chromosomal rearrangements are placed in non-adjacent target... Agent: Scott R. Maynard

20070238118 - Methods and kits for sequentially isolating rna and genomic dna from cells: Methods for obtaining nucleic acid from nucleated cells are disclosed, wherein RNA and fragmented genomic DNA can be sequentially obtained from the same starting material are disclosed. In some embodiments, protein can also be obtained from the same starting material as the RNA and DNA are obtained. According to certain... Agent: Ambion

20070238125 - Probe synthesis method for nucleic acid detection: The present invention relates to a probe synthesis method and a probe synthesis kit for nucleic acid detection, which are intended for the fluorophore labeling and detection of a target gene. In this method, a probe unit for analyte nucleic acid recognition having a base sequence specific to an analyte... Agent: Reed Smith LLP Suite 1400

20070238148 - Food waste treatment device using microorganisms: The present invention is directed to a composition for decomposing a majority of food waste into water and carbon dioxide comprising an effective combination of at least two species of microorganisms chosen from bacillus, lactobacillus, burkholderia, yeast fungus, eumycetes or any combinations thereof. A preferred embodiment comprises a combination of... Agent: Davidson, Davidson & Kappel, LLC

20070238086 - Identification of oligonucleotides for the capture, detection and quantitation of west nile virus: West Nile virus capture oligonucleotides, primers and probes derived from conserved regions of the West Nile virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes.... Agent: Novartis Vaccines And Diagnostics Inc.

20070238091 - Artificial receptors, building blocks, and methods: The present invention relates to artificial receptors and arrays or microarrays of artificial receptors or candidate artificial receptors. Each member of the array includes a plurality of building block compounds, which can be immobilized in a spot on a support. The present invention also includes the building blocks, combinations of... Agent: Merchant & Gould PC

20070238088 - Hydrophilic functionalized colloidal silica compositions, methods of making, and uses therefor: Disclosed are hydrophilic functionalized silica compositions that are stable and do not show significant pH increases upon heat sterilization. Also provided are methods to make hydrophilic functionalized silica compositions by reacting acidic silica particles with hydrophilic organosilanes. Further provided are methods of separating components in a mixture using hydrophilic functionalized... Agent: General Electric Company Global Research

20070238092 - Method and device for the detection, measurement and analysis of biological, bioactive, bioenergetic and bioharmonic signals: Device and method for the detection of a bioharmonic field emanating from an organism. Includes a base oscillator, for radiating an audio frequency to the organism under test, and a modulation oscillator, for combining an electromagnetic signal received from the organism under test with an audio carrier.... Agent: Blank Rome LLP

20070238087 - Positronium-mediated method for identifying an organism: A monitor is provided for measuring the presence of a small concentration of at least one hazardous material within a vessel. A positron source emits positrons into an annihilation region of the vessel. A plurality of species of positronium are formed from the positrons as they interact with a sample... Agent: Duane Morris LLPIPDepartment

20070238093 - Detection of influenza a virus: The invention provides methods to detect influenza A in biological samples using real-time PCR. Primers and probes for the detection of influenza A are provided by the invention. Articles of manufacture containing such primers and probes for detecting influenza A are further provided by the invention.... Agent: Fish & Richardson P.C.

20070238094 - Diagnosis, prognosis and monitoring of disease progression of systemic lupus erythematosus through blood leukocyte microarray analysis: The present invention includes compositions, systems, arrays and methods for the early detection and consistent determination of SLE using modular analysis of gene expression data.... Agent: Chalker Flores, LLP

20070238096 - Hybrid energy transfer for nucleic acid detection: Assays using enzymatic degradation of RNA/DNA heteroduplexes are provided for the detection of target nucleic acid molecules. Such enzymatic degradation may be obtained by enzymes including RNaseH. Exemplary methods include Probe Trapping (PT), Hybrid Energy Transfer (HET), and Fluorescent Probe Degradation (FPD). The assays make use of an RNA or... Agent: Heller Ehrman LLP

20070238099 - Antigen receptor variable region typing: A method of typing a variable region of a specific variant of an antigen receptor chain is disclosed. The method comprises: (a) exposing a probe set to a sense or antisense strand of a polynucleotide encoding at least a portion of the variable region of the specific variant of the... Agent: Martin D. Moynihan Prtsi, Inc.

20070238116 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent: Casimir Jones, S.c.

20070238124 - Differentially expressed genes related to coronary artery disease: Disclosed are genes and peptides whose expression is correlated to the prevalence of coronary artery disease. Also provided are methods of prognosis, diagnosis and methods of monitoring coronary artery disease based on the measurement of gene expression.... Agent: Novartis Corporate Intellectual Property

20070238102 - Enzymatic detection techniques: A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes substrate conjugates to facilitate the detection of the enzyme or enzyme inhibitor via direct detection of the substrate and/or a product formed in an enzyme-catalyzed reaction of the... Agent: Dority & Manning, P.A.

20070238110 - Genetic test for the identification of dwarfism in cattle: Genetic markers for identifying bovine carriers of dwarfism in cattle, particularly Angus cattle is described. The genetic markers, including the microsatellite markers BMS4311 and AFR227 and the bovine PRKG2, BMP2K, BMP3, FGF5 genes, are located on bovine chromosome BTA6. One SNP, a polymorphism is located in the protein kinase domain... Agent: Mckee, Voorhees & Sease, P.L.C

20070238105 - High resolution chromosomal mapping: The present invention generally relates to spatial and structural genomic analysis compositions, which can be used for the mapping of chromosomes and structural analyses of chromosomal rearrangements, including the entire chromosome, as well as specific portions or regions of interest of the chromosomes. In some embodiments, multiple portions of the... Agent: Agilent Technologies Inc.

20070238111 - Identification of genes or polypeptides the expression of which correlates to fertility, ovarian function and/or fetal/newborn viability: A genetic means of determining whether a female subject produces “pregnancy competent” oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level,... Agent: Hunton & Williams LLP Intellectual Property Department

20070238100 - Integrated methodologies for the detection and genotyping of human papillomaviruses: Methods and compositions for detecting, typing or characterizing HPV DNA are disclosed. The methods can include isolation of DNA from a patient and amplifying any L1 region of HPV in the sample. The amplicon from the L1 region may be analyzed to determine at least one of the presence of... Agent: Cyr & Associates, P.A.

20070238126 - Labelled beads: A labelled polymeric bead wherein individual beads comprise a primary particle formed of a synthetic polymeric material, and at least one secondary particle entrapped within the primary particle of the bead and being comprised of a synthetic polymer material incorporating reporter moieties.... Agent: Goodwin Procter LLP Patent Administrator

20070238098 - Method and kit for predicting adverse side effects of paclitaxel therapy: A method is disclosed for predicting the risk of the occurrence of granulocytopenia caused by paclitaxel therapy in a subject. The method of the present invention comprises identifying a genetic polymorphism in a gene isolated from the subject for five SNPs in CYP2C8 gene (IMS-JST111898 (SEQ ID NO: 1), IMS-JST105874... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner

20070238119 - Method for detecting cancer and method for suppressing cancer: An object of the present invention is to provide a method for detecting cancer through identification of genes exhibiting characteristic behavior in the cases of cancer such as anaplastic thyroid cancer. The present invention provides a method for detecting cancer which comprises detecting canceration of a specimen using the amplification... Agent: Birch Stewart Kolasch & Birch

20070238113 - Method for detecting mutations and/or polymorphisms: The method of the present invention is based on a method wherein a nucleic acid is synthesized utilizing the hybridized 3′-end, which is synthesized by complementary strand synthesis, on a specific region of a target nucleotide sequence existing as the nucleotide sequence of the same strand as the origin for... Agent: Nixon Peabody LLP - Patent Group

20070238123 - Method for determining cell cycle position: The invention provides a novel, non-destructive and dynamic process for determining the cell cycle position of living cells. The invention also provides DNA constructs, and cell lines containing such constructs, that exhibit activation and deactivation of a detectable reporter molecule in a cell cycle specific manner. The invention thus allows... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070238117 - Method for retaining methylation pattern in globally amplified dna: A method for preserving information about cytosine methylation status in amplified nucleic acid molecules is disclosed. The method includes contacting a sample that contains nucleic acid molecules, such as nucleic acid molecules having or suspected of having methylated cytosines, with a modifying agent that converts the unmethylated cytosines to produce... Agent: Klarquist Sparkman, LLP

20070238115 - Method of diagnosing and treating colon cancer: The invention provides a method of diagnosing carcinoma in a patient, the method comprising providing a sample of colorectal cells from a human patient and analyzing the sample for CXCL12 hypermethylation.... Agent: Quarles & Brady LLP

20070238127 - Methods of identifying and isolating stem cells and cancer stem cells: Methods and compositions are provided for the identification of stem cells and cancer stem cells. β-catenin is also identified as a target for the development of therapeutic moieties against hematopoietic tumors, i.e. leukemia and lymphoma cells, which may include screening assays directed at β-catenin, or members of the β-catenin signaling... Agent: Bozicevic, Field & Francis LLP

20070238112 - Microfluidic and nanofluidic electronic devices for detecting changes in capacitance of fluids and methods of using: The present invention (also identified as “Capacitance cytometry”) relates to microfluidic and nanofluidic devices for detecting or measuring an electrical property of a fluid (liquid or aerosol), a single molecule, particle, or cell in fluid. In a particular embodiment, the devices detect or measure changes in capacitance of a fluid,... Agent: Townsend And Townsend And Crew, LLP

20070238120 - Mold infections: Isolated nucleic acids, kits and methods are disclosed for detecting, quantifying and/or identifying a fungal species in a sample or for diagnosing jejunal hemorrhage syndrome in a subject. The methods generally include amplifying a fungal nucleic acid sequence present in the sample using a primer selected from the group consisting... Agent: Lumen Intellectual Property Services, Inc.

20070238101 - Nucleic acid interaction analysis: The present invention provides an isolated oligonucleotide and a method using the isolated oligonucleotide to detect and/or identify at least two polynucleotides from a nucleic acid-protein complex. The oligonucleotide comprises at least one first tag and at least one second tag, wherein the first and second tags are obtained from... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070238122 - Systems and methods for efficient collection of single cells and colonies of cells and fast generation of stable transfectants: A plate manufactured to enable samples of cells, micro-organisms, proteins, DNA, biomolecules and other biological media to be positioned at specific locations or sites on the plate for the purpose of performing addressable analyses on the samples. Preferably, some or all of the sites are built from a removable material... Agent: Orrick, Herrington & Sutcliffe, LLPIPProsecution Department

20070238106 - Systems and methods of determining alleles and/or copy numbers: Various aspects of the invention include a solid support having a first region with a first nucleic acid, and second, third, fourth and fifth regions having, respectively, second, third, fourth, and fifth nucleic acids each having a length that is shorter than the length of the first nucleic acid. Certain... Agent: Agilent Technologies Inc.

20070238108 - Validation of comparative genomic hybridization: The present invention generally relates to techniques involving comparative genomic hybridization (CGH) and related techniques, including the validation of assay results. In one aspect, a region of interest of a genome or other target nucleic acid, identified using CGH or similar techniques, may be validated using a probe based on... Agent: Agilent Technologies Inc.

20070238129 - Catalytically inactive enzymes for affinity binding: Provided is a catalytically-inactive, dual-specificity phosphatase (dsPTP) or peptidomimetic affinity capture molecule attached to a matrix, for binding a phosphorylated polypeptide. The invention further provides a method for removing a phosphorylated polypeptide from a sample using the composition and kits useful in the practice of the method.... Agent: Agilent Technologies Inc.

20070238133 - Immunoglobulins devoid of light chains: There is provided an isolated immunoglobulin comprising two heavy polypeptide chains sufficient for the formation of a complete antigen binding site or several antigen binding sites, wherein the immunoglobulin is further devoid of light polypeptide chains.... Agent: Wolf Greenfield & Sacks, P.C.

20070238128 - Method for screening substances capable of promoting oligomerization of receptor protein molecules: The present invention provides a method for screening substances that promote oligomerization of receptor protein molecules or peptide fragments thereof, which comprises determining whether the receptor protein molecules or peptide fragments thereof are oligomerized when contacted with a test substance; a test kit for screening substances that promote the oligomerization... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070238130 - Novel metalloproteinases: The present invention relates to novel metalloproteinase- like proteins. In particular, isolated nucleic acid molecules are provided encoding the human TACE-like and matrilysin-like proteins. TACE-like and matrilysin-like polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070238131 - Reaction vessel: Reaction vessel 1 for assaying of a subject substrate molecule comprises a translucent narrow tube 2 which has a liquid feed port 4 at one end, and which is intended to be packed with microparticles 5 as solid phase support on which a reagent molecule is bound thereto, in which... Agent: Marshall, Gerstein & Borun LLP

20070238132 - Screening of combinatorial libraries using radioactivity: The combinatorial approach to materials synthesis can create vast libraries of materials. Some luminescent materials can be activated by the application of electrical current. Additionally, these materials can be activated by the application of an electron gun or some other electron source, such as a β-emitter. In its simplest form,... Agent: Buchanan, Ingersoll & Rooney PC

20070238134 - Cell cycle proteins associated with rad9, compositions and methods of use: The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to... Agent: Townsend And Townsend And Crew, LLP

20070238135 - Novel g-protein coupled receptor and dna sequences thereof: This invention relates to newly identified polypeptides and polynucleotides encoding such polypeptides, to their use in diagnosis and in identifying compounds that may be agonists, antagonists that are potentially useful in therapy, and to production of such polypeptides and polynucleotides, belonging to the class of G-protein coupled receptors.... Agent: Novartis Corporate Intellectual Property

20070238137 - Constitutively resistant cancer stem cells in diagnosis: The invention provides a method of identifying circulating clonogenic cancerous cells, specifically multiply-drug resistant (MDR) cancer stem cells.... Agent: Leydig Voit & Mayer, Ltd

20070238138 - Consumer food testing device: A food testing device for testing for the presence of harmful contaminants in a food sample, includes a vessel adapted for holding a liquefied food sample, a liquefier operatively associated with the vessel for converting an unliquefied food sample into a liquefied food sample, at least one test assay dispensable... Agent: Kenneth Watov, Esq. Watov & Kipnes, P.C.

20070238139 - Method and device for rapid detection of microorganisms by changing the shape of micro-colonies: This invention describes a method of rapid detection of micro-colonies of microorganisms by changing their shape from a regular semi-sphere to a long and thin cylinder. Cells are trapped by filtration in long (diameter/length=1/10-1/100), cylindrical, parallel, micro-channels that are open from both sides, and attached to a filter from one... Agent: Eckert Seamans Cherin & Mellott

20070238136 - Assays and peptide substrate for determining aggrecan degrading metallo protease activity: This invention is directed to assays to determine the presence or absence of proteins that exhibit aggrecanase or ADMP activity. This invention also relates to peptides that acts as a substrates for ADMPs, their use in various assays to determine the presence or absence of ADMP activity, and their use... Agent: Louis J. Wille Bristol-myers Squibb Company

20070238141 - Method for measuring kinase activity: A method for measuring the activity of a receptor kinase present in a cell membrane of a cell is described. The method comprises steps of preparing a sample containing the receptor kinase by separating a cytoplasm from the cell, contacting the receptor kinase in the sample with a substrate to... Agent: Sughrue Mion, PLLC

20070238140 - Method for multiplex bead-based assays using chemiluminescence and fluorescence: A method for detecting a target analyte in a sample, the method having the steps of: binding the target analyte to a fluorescently coded particle capable of specifically binding to the target analyte; labeling the target analyte with a first chemiluminescence component; adding a second chemiluminescence component to the labeled... Agent: Beckman Coulter Inc. C/o Sheldon Mak Rose & Anderson

20070238142 - Small molecule mediated biosensing using carbon nanotubes in homogeneous format: Nanosensors for detecting target analytes and methods of detecting analytes have been developed in which a small molecule effector concentration is altered thereby causing changes in carbon nanotube conductance. The nanosensor operates in a homogeneous format, not requiring the immobilization of the target analyte for detection.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070238143 - Metal ion mediated fluorescence superquenching assays, kits and reagents: Reagents and assays for kinase, phosphatase and protease enzyme activity which employ metal ion-phosphate ligand specific binding and fluorescent polymer superquenching are described. The assays provide a general platform for the measurement of kinase, phosphatase and protease enzyme activity using peptide and protein substrates. Reagents and assays based on DNA... Agent: Peacock Myers, P.C.

20070238144 - Cell cycle reporting cell line: The present invention relates to non-destructive and dynamic means for determining the cell cycle position of living cells. The invention provides stable cell lines which can be used to determine the cell cycle position, together with methods for measuring the effect of a test agent on the cell cycle position.... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070238145 - Phenotypic engineering of spores: The biological functionality of living microbial spores is modified using phenotypic engineering to endow the resulting modified spores with novel functionality that extends the usefulness of the spores for a variety of practical applications including, for example, sterility testing, the release of active compounds, and cell-based biosensing systems. A preferred... Agent: Bruce F. Jacobs Jacobs Patent Office

20070238146 - Kinetic metabolic assay for antifungal susceptibility testing: Methods for determining viable cell numbers and percentages are provided. The kinetic profile of a metabolic indicator associated with the cells may be analyzed to determine the number of viable cells in the starting population. Cells may be cultured with a molecule of interest and the effect of that molecule... Agent: Trask Britt

20070238147 - Method of detecting foreign matter: A method for detecting foreign matter such as a parasite, in particular, to provide a method for detecting parasitic on meat. A method for detecting foreign matter includes detecting fluorescence excited by irradiating the foreign matter such as a parasite with visible light. The method is suitable for detecting a... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20070238149 - Mutant carotenoid ketolases: CrtW carotenoid ketolases are provided that are useful for the production of astaxanthin and other cyclic ketocarotenoids. The mutant ketolase genes of the present invention encode polypeptides characterized by an improvement in astaxanthin synthesis activity when converting cyclic hydroxylated carotenoid intermediates into astaxanthin. Expression of the mutant carotenoid ketolases in... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070238152 - Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid phenylselenocysteine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal aminoacyl-tRNA synthetases, polynucleotides encoding the novel synthetase molecules, methods... Agent: Quine Intellectual Property Law Group, P.C.

20070238151 - Novel compounds: Polypeptides and polynucleotides of the genes set forth in Table I and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing polypeptides and polynucleotides of the genes set forth in Table I in diagnostic assays.... Agent: Glaxosmithkline Corporate Intellectual Property - Uw2220

20070238150 - Pro4356 polypeptides: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Knobbe, Martens, Olson & Bear, LLP

20070238153 - Processes for improved disulfide bond formation in recombinant systems: Methods and prokaryotic expression systems for producing recombinant disulfide bond-containing proteins are described including increasing the level of at least one redox cofactor in the cell to enhance disulfide bond formation are disclosed. Processes of increasing levels of redox cofactors include media supplementation and genetic modification of the host cell.... Agent: Trask Britt

20070238154 - Humanized antibodies that recognize beta-amyloid peptide: The invention provides improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient. Preferred agents include humanized antibodies.... Agent: Lahive & Cockfield, LLP / Elan

20070238155 - Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose: This invention provides novel enzyme compositions using newly identified and isolated C. lucknowense enzymes, including CBH Ib CBH IIb, EG II, EG VI, β-glucosidase, and xylanase II in conjunction with previously identified enzymes CBH Ia, CBH IIa (previously described as Endo 43), and EG V. These enzyme compositions demonstrate an... Agent: Morgan & Finnegan, L.L.P.

20070238156 - Biocatalytic manufacturing of (meth) acrylylcholine or 2-(n, n-dimethylamino) ethyl (meth) acrylate: A biocatalytic method for the synthesis of 2-(N,N-dimethylamino)ethanol and/or choline esters of acrylic acid and/or methacrylic acid, namely a method or process for the manufacture of acrylylcholine and/or methacrylylcholine, comprising reacting 2-(N,N-dimethylamino)ethanol and/or choline with acrylyl-CoA and/or methacrylyl-CoA in the presence of a biocatalyst with choline acetyltransferase activity, where preferably... Agent: Ciba Specialty Chemicals Corporation Patent Department

20070238157 - Production of isoprenoids: The invention provides a biological method of producing isoprenoids.... Agent: Sheridan Ross PC

20070238158 - Method for enhancing enzyme activity at elevated temperature: A method for enhancing activity of enzyme at an elevated temperature which comprises adding a substance exhibiting chaperone function such as a saccharide to a reaction mixture containing the enzyme. The method can improve activity of enzymes more easily and more effectively and hence afford increased enzyme activity at an... Agent: Buchanan, Ingersoll & Rooney PC

20070238159 - Production of isoprenoids: The invention provides a biological method of producing isoprenoids.... Agent: Sheridan Ross PC

20070238160 - Production of isoprenoids: The invention provides a biological method of producing isoprenoids.... Agent: Sheridan Ross PC

20070238161 - Instrument for monitoring polymerase chain reaction of dna: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the... Agent: Kilyk & Bowersox, P.l.l.c.

20070238164 - Plastic microchip for microparticle analysis and method for manufacturing the same: According to the present invention, it is possible to form a microgrid pattern of a relatively narrow width deeply and uniformly as a negative microgrid pattern is formed on the lower substrate and thereby to provide a clear microgrid pattern, thus facilitating accurate observation of microparticles. Moreover, it is also... Agent: Frommer Lawrence & Haug

20070238163 - Covalent attachment of biomolecules to solid supports by a polymerization method: Described herein is a novel approach for the immobilization of one or more biomolecules or biomolecule complexes to solid supports. The method describes the modification of a solid support, if required, attaching functionality to a biomolecule or biomolecule complex, and linking the biomolecule or biomolecule complex to the solid support.... Agent: Barnes & Thornburg LLP

20070238162 - Measuring apparatus for interaction of biomolecule: In a measuring apparatus for biomolecule interaction, a fine particle sensor surface is dipped in a buffer solution in a reaction vessel to conduct spectral measurement by way of optical fibers. The buffer solution in the reaction vessel is made to enter an upper reaction vessel and discharged from a... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070238165 - Method and device for measuring multiple physiological properties of cells: A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media, and analyzing... Agent: Goodwin Procter LLP Patent Administrator

20070238166 - Dual purpose intermodal and bioconversion container: An Intermodal container, also known as an ISO Ocean Freight Container is suitable for the dual purposes of bio-containment and also Intermodal shipping. Provision is made for the introduction of water, oxygen or other liquids or gasses to be treated into the container, for exit of liquids or gasses generated... Agent: Albert W. Watkins

20070238169 - Cell sorter and culture system: Methods and apparatus are provided for culturing cells under conditions for determining cellular differentiation and for separating cells from culture media based on differentiation. The apparatus comprises a bioreactor, media reservoir, a magnetic cell separator, an inlet port for adding magnetic particles to the bioreactor, and a circulating pump, wherein... Agent: Peters Verny , L.L.P.

20070238168 - Double mutant alpha-7 nicotinic acetylcholine receptor: The invention relates to a novel methods for measuring ion channel transmission and methods and compositions useful in the indentification of ligand gated channel agonists and modulators.... Agent: Pfizer Inc

20070238167 - Flat microfibers as matrices for cell growth: The present invention relates to culturing cells utilizing a matrix of microfibrillated thermoplastic polymeric materials. More specifically, the present invention relates to a method of culturing cells. In addition, the invention relates to a microfibrillated article for culturing cells dispersed in a cell culture medium. The matrix of thermoplastic polymeric... Agent: 3m Innovative Properties Company

20070238170 - Culturing human embryonic stem cells: Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells in an undifferentiated state. It has now been found that if high levels of fibroblast growth factor are... Agent: Quarles & Brady LLP

20070238171 - Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations: Enriched neural stem and progenitor cell populations, and methods for identifying, isolating and enriching for neural stem cells using reagent that bind to cell surface markers, are provided.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070238172 - Methods of isolating bipotent hepatic progenitor cells: A method of obtaining a mixture of cells enriched in hepatic progenitors is developed which comprises methods yielding suspensions of a mixture of cell types, and selecting those cells that are classical MHC class I antigen(s) negative and ICAM-1 antigen positive. The weak or dull expression of nonclassical MHC class... Agent: Foley And Lardner LLP Suite 500

20070238173 - Laminate of cultured human corneal endothelial cells layer and method for manufacturing same: A laminate comprising a transparent collagen I type sheet and a human corneal endothelial cell culture layer provided on the sheet. An endothelial cell culture layer laminate usable in transplantation is provided.... Agent: Ditthavong Mori & Steiner, P.C.

20070238174 - Substrates: The present invention relates to novel substrates, to methods of making them and to uses therefor. The substrates of the invention comprise a base portion and a surface layer covering at least part of the base portion, with a binding layer provided therebetween. The surface layer provides, on at least... Agent: Waddey & Patterson, P.C.

20070238175 - Standardization of processes for culturing primary cells: The present invention provides a standardized tissue-specific and cell-specific kit and methods for promoting the enrichment and expansion of primary cells in culture while reducing the contamination of unwanted cell types. The present invention further provides the compositions for optimized tissue-specific and cell-type specific dissociation of tissues and inhibition of... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070238177 - Devices and methods for tissue transplant and regeneration: Devices and methods for transplanting tissue for the purpose of regeneration, for treating a patient having injured myocardial tissue, and/or for improving cardiac function through cell regrowth. More specifically, the devices and methods obviate the need for cellular alteration. The devices comprise a hollow tube with a sharp distal end,... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20070238176 - Bioreactor design and process for engineering tissue from cells: A scaled-up multi-coaxial fiber bioreactor, and variations of this bioreactor. The device is characterized by a hollow housing and an array of from about 20 to about 400 modules of hollow fibers, where each module includes at least three coaxial semipermeable hollow fibers. The innermost fiber provides a boundary for... Agent: Foley And Lardner LLP Suite 500

20070238178 - Methods and compositions for inhibiting the function of polynucleotide sequences: A therapeutic composition for inhibiting the function of a target polynucleotide sequence in a mammalian cell includes an agent that provides to a mammalian cell an at least partially double-stranded RNA molecule comprising a polynucleotide sequence of at least about 200 nucleotides in length, said polynucleotide sequence being substantially homologous... Agent: Wyeth Patent Law Group

20070238179 - Cell division and proliferation preferred regulatory elements and uses thereof: The present invention provides compositions and methods for regulating expression of nucleotide sequences in a plant. The compositions are novel nucleic acid sequences which confer cellular division and/or proliferation-preferred regulation of operably attached nucleotide sequences. Methods for expressing an isolated nucleotide sequence in a plant using the regulatory sequences, expression... Agent: Pioneer Hi-bred International, Inc.

20070231787 - Methods and devices for imaging and manipulating biological samples: Methods of imaging biological samples are provided. Aspects of embodiments of the methods include freezing, thawing and imaging a biological sample, one or more times, in a manner sufficient to image the biological sample while maintaining the viability and/or structural integrity of the sample. Also provided are devices and systems... Agent: Bozicevic, Field & Francis LLP

20070231789 - Tumor models employing green fluorescent protein: The present invention relates to a LOX-GFP marker and methods of analyzing tumor burden in ascites or in lung. The invention also relates to a new LOX-GFP-LM cell line which demonstrates increased lung metastasis. The methods of the invention result in better quantitative tumor burden assessment and improved efficacy evaluation.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20070231800 - Determination of methylated dna: The present invention generally relates to the determination of the state of one or more locations within a nucleic acid and, in particular, to the determination of the methylation state of one or more methylation sites within a nucleic acid such as DNA. In one aspect of the invention, a... Agent: Agilent Technologies Inc.

20070231799 - Method and apparatus for applying continuous flow and uniform temperature to generate thermal melting curves in a microfluidic device: The present invention provides a method for performing thermal melt analysis using a microfluidic device, the method comprising providing a microfluidic device having at least one microfluidic channel, introducing fluid comprising into the at least one microfluidic channel, continuously flowing the fluid through the at least one microfluidic channel while... Agent: Canon U.s.a. Inc. Intellectual Property Division

20070231798 - Microwave assisted pcr amplification of dna: A method of microwave assisted nucleic acid amplification by PCR is disclosed. The method includes denaturing, annealing, and extending a nucleic acid sample, with at least the denaturing and extension steps being carried out under the influence of microwave radiation, while preventing the temperature of the sample from varying more... Agent: Summa, Allan & Additon, P.A.

20070231838 - Method for the assay of rock kinase activity in cells: The present invention provides a method for determining the intracellular activity of ROCK kinase comprising, providing a sample of cells to be tested for ROCK kinase activity, determining the level of phosphorylation of MYPT1 in the sample, and determining the intracellular activity of ROCK kinase in the sample of cells,... Agent: Osi Pharmaceuticals, Inc.

20070231846 - Glucose meter communication method and system: Methods for communicating between a glucose meter and a computing system are described. One method includes automatically initiating a communication session with a computing system over a communication link. The method also includes automatically sending data from the glucose meter to the computing system via the communication link.... Agent: Erik G. Swenson Merchant & Gould P.C.

20070231852 - Rapid detection of mold by accelerated growth and detection: The invention includes a method of detecting the presence or absence of mold in a sample. The method can include the step of applying a sample suspected of containing the mold to a growth medium, optionally fragmenting the sample, associating the sample with a labeling agent, and detecting the presence... Agent: Intellectual Property Group Fredrikson & Byron, P.A.

20070231855 - Functional molecule and manufacturing method therefor: A novel method for efficiently manufacturing a functional molecule with affinity for a target substance is provided along with a functional molecule manufactured by this method. The method for manufacturing a functional molecule includes binding, to a resin, a specific substance having a cleavable linker which is a site that... Agent: Kratz, Quintos & Hanson, LLP

20070231785 - Biological sample handling and imaging: Disclosed are methods and systems for microscope imaging that involve positioning a biological sample within a field of view of a microscope having an optical axis, and rotating the biological sample about a rotation axis different from the optical axis to improve an image of the sample produced by the... Agent: Fish & Richardson PC

20070231786 - Biosensor: The illustrated embodiment comprises a biosensor utilizing plant cells and nutrient media for maintaining the plant cells in a live condition. A light source having desired optical characteristics is directed onto the plant cells and light spectra transmitted from the cells is detected by a photodetector. A controller analyzes signals... Agent: Hewlett Packard Company

20070231788 - Method for in vitro assay of demineralized bone matrix: A sensitive, quantitative method to assess bone forming potential of demineralized bone matrix (DBM) is provided. Cortical DBM is treated with collagenase. The treated cortical DBM is placed in a cell culture for a dwell time. After the dwell time, the cell culture is observed for osteoblastic markers. The cortical... Agent: Dorsey & Whitney LLP Intellectual Property Department

20070231784 - Quantitation of oocytes and biological samples using birefringent imaging: Disclosed are methods and systems for assessing the developmental potential of an oocyte based on one or more quantitative metrics derived from one or more birefringence images of a sample comprising the oocyte, wherein the assessing comprises comparing the one or more quantitative metrics to reference information.... Agent: Fish & Richardson PC

20070231783 - Synthetic microfluidic microvasculature network: The present invention is a synthetic microfluidic microvasculature network and associated methods. The synthetic microfluidic microvasculature network mimics the structure, fluid flow characteristics, and physiological behavior of physiological microvasculature networks. Computational methods for simulating flow and particle adherence in synthetic and physiological microvascular systems and methods for determining parameters influencing... Agent: Tomas Friend, Ph.d.

20070231790 - Photo-activated field effect transistor for bioanalyte detection: The application relates to a device and method for performing analyte detection, especially biomolecule detection. The device and method combine photo-induced charge separation in label materials and field effect transistors as sensors, resulting in more sensitive, specific and/or selective detections of biomolecules in multiplex assays, such as immunoassays and DNA... Agent: Darby & Darby P.C.

20070231817 - 4c: The present invention relates in one aspect to a method for analysing the frequency of interaction of a target nucleotide sequence with one or more nucleotide sequences of interest (eg. one or more genomic loci) comprising the steps of: (a) providing a sample of cross-linked DNA; (b) digesting the cross-linked... Agent: Frommer Lawrence & Haug

20070231815 - Compositions and kits for detection of a target nucleic acid: The present invention is directed to kits and compositions for generating a signal indicative of the presence of a target nucleic acid sequence in a sample, comprising a nucleic acid polymerase lacking 5′ to 3′ exonuclease activity and a thermostable FEN nuclease consisting of a 5′ to 3′ exonuclease and/or... Agent: Agilent Techologies Inc

20070231811 - Diagnostic and prognostic methods of non-alcoholic steatohepatitis (nash): A set of genes that are expressed differentially in normal and NASH-predisposed liver, thus constituting the genomic signature of NASH, is provided. The set of genes can be used to discriminate between normal and NASH-predisposed liver tissues. Accordingly, diagnostic assays for classification of pathological grades, prediction of the pathology outcome,... Agent: Intellectual Property / Technology Law

20070231823 - Directed enrichment of genomic dna for high-throughput sequencing: The present invention provides microarrays of oligonucleotide primer pairs, and in particular, microarrays of primers that comprise at least one cleavable linkage. Also provided are methods to capture oligonucleotide primer pairs from one or more microarrays, and methods to use the captured oligonucleotide primer pairs, such as for amplification of... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070231814 - Dna sequences isolated from human colonic epithelial cells: The present invention discloses novel nucleic acid sequences which are implicated in the growth regulation of the epithelial cells of the colon, and which sequences are differentially expressed in cancerous colon tissues compared to normal colon tissues. These sequences are useful in diagnosing abnormal cell growth, treatment of abnormal cell... Agent: Edwards Angell Palmer & Dodge LLP

20070231813 - Fcgr3a gebotype and methods for evaluating treatment response to non-depleting antibodies: The present invention relates to methods and compositions to evaluate or assess the response and/or side effects of a subject to particular therapeutic treatment. More particularly, the invention provides methods to determine the response and/or side effects of subjects, or to adapt the treatment protocol of subjects treated with therapeutic... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070231791 - Gene equation to diagnose rheumatoid arthritis: The presently clamied subject matter provides a method for detecting a predisposition to developing established rheumatoid arthritis (RA) in a subject by obtaining a biological sample from the subject, determining expression levels of at least two genes in the biological sample, and comparing the expression level of each gene with... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20070231792 - Human g protein-coupled receptor and modulators thereof for the treatment of cardiovascular disorders: The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In some embodiments, the GPCR is mammalian, preferably human. In some embodiments, the GPCR is expressed endogenously by cardiomyocytes. In some embodiments, the GPCR is coupled to Gq. In... Agent: Bozicevic, Field & Francis LLP (aren) (arena Pharmaceuticals, Inc.)

20070231818 - Luminescent compounds having a functionalized linker arm used in the bioconjugation and labeling of biomolecules: The present invention relates to luminescent compounds having a functionalised linker arm, their synthesis and use in bioconjugation and labelling of biomolecules, such as for example nucleosides, nucleotides, nucleic acids (DNA, RNA or PNA) and proteins, as well as their use in the execution of in vitro and in vivo... Agent: Nixon & Vanderhye, PC

20070231793 - Method for direct detection of fungal pathogens: The present invention relates to a method and diagnostic kit for directly detecting the presence of a specific species of mold/fungi in a sample, particularly a species which is toxic to humans or animals including pets and livestock. The method involves releasing any fungal DNA from the sample and subjecting... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070231802 - Method for evaluating integrity of a genomic sample: Described herein is a method of evaluating a genomic sample. One embodiment of the instant method generally includes amplifying a relatively long genomic sequence and a relatively short genomic sequence from a genomic sample, and comparing the amounts of amplification products produced.... Agent: Agilent Technologies Inc.

20070231806 - Method for labeling rna: Novel methods for labeling RNA in a sample are described, as well as methods of performing an array analysis of a labeled RNA sample.... Agent: Agilent Technologies Inc.

20070231807 - Method for preparing short hairpin rna from cdna: The present invention provides a method for generating double stranded palindromic DNA sequences which form short hairpin RNAs in a host cell, wherein a nicking DNA enzyme opens a double stranded DNA and converts it to a single stranded palindromic structure. The present invention also provides methods for expressing shRNA... Agent: Senniger Powers

20070231812 - Method of screening antidiabetic agents: A method of screening for an antidiabetic agent comprising (1) bringing a test substance into contact with a cell which overexpresses a polypeptide exhibiting an activity of suppressing insulin secretion under a high glucose concentration by an overexpression of the polypeptide in pancreatic β cells, and comprising an amino acid... Agent: Sughrue Mion, PLLC

20070231795 - Methods and apparatus for nucleic acid sequencing by signal stretching and data integration: The methods and apparatus 100 disclosed herein concern DNA sequencing. In some embodiments of the invention, the methods comprise measuring the distance between labeled nucleotides 220, such as nucleotides labeled with bulky groups. The methods may further comprise placing identical template DNA 200 into four reaction chambers 110, 120, 130,... Agent: Raj S. Dave Morrison & Foerster LLP

20070231821 - Methods and compositions for detecting polynucleotides: Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a polynucleotide that may include nucleic acid analogs and that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which... Agent: Brinks Hofer Gilson & Lione

20070231797 - Methods and compositions for diagnosing lung cancer with specific dna methylation patterns: The present invention provides a method for identification of differentially methylated genomic CpG dinucleotide sequences within genomic target sequences that are associated with cancer in an individual by obtaining a biological sample comprising genomic DNA from the individual measuring the level or pattern of methylated genomic CpG dinucleotide sequences for... Agent: Mcdermott, Will & Emery

20070231822 - Methods for the detection and treatment of cancer: Methods are provided for the detection of and determining prognosis of metastatic breast, lung, prostate, and/or pancreatic cancer using various genetic markers, including markers for gene clusters linked by Esx. In one method, breast cancer micrometastases and non-small cell lung cancer metastases or micrometastases are detected in a patient by... Agent: Needle & Rosenberg, P.C.

20070231808 - Methods of nucleic acid analysis by single molecule detection: This invention provides a method of nucleic acid analysis that enables highly accurate and sensitive quantitation by counting the number of molecules among a plurality of types of genes without amplifying specific genes and that enable reduction of quantitation limits. This method comprises steps of: allowing a polynucleotide comprising a... Agent: Stanley P. Fisher Reed Smith LLP

20070231809 - Methods of using fet labeled oligonucleotides that include a 3'-5' exonuclease resistant quencher domain and compositions for practicing the same: Methods and compositions are provided for detecting a primer extension product in a reaction mixture. In the subject methods, a primer extension reaction is conducted in the presence of a polymerase having 3′→5′ exonuclease activity and at least one FET labeled oligonucleotide probe that includes a 3′→5′ exonuclease resistant quencher... Agent: Invitrogen C/o Intellevates Sughrue Mion PLLC

20070231804 - Methods, systems and compositions for monitoring enzyme activity and applications thereof: Methods of monitoring enzyme mediated reactions, and particularly nucleic acid synthesis reactions such as pyrosequencing methods that employ enzymatic reporter systems. The methods and systems provide elevated signal levels as compared to conventional pyrosequencing processes, and/or mediate de-phasing of sequencing analyses employing pyrosequencing or other “sequencing by synthesis” methods.... Agent: Pacific Biosciences Of California, Inc.

20070231816 - Module-level analysis of peripheral blood leukocyte transcriptional profiles: The present invention includes an apparatus, system and method for the development and use of transcriptional modules by obtaining individual gene expression levels from cells obtained from one or more patients with a disease or condition; recording the expression value for each gene in a table that is divided into... Agent: Chalker Flores, LLP

20070231825 - Multianalyte molecular analysis using application-specific random particle arrays: The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence... Agent: Eric P. Mirabez

20070231810 - Multicomponent nucleic acid enzymes and methods for their use: The present invention relates to Multicomponent Nucleic Acid Enzymes (MNAzymes) and methods for their use. MNAzymes comprise two or more oligonucleotide components which self-assemble in the presence of one or more MNAzyme assembly facilitator molecules to form a catalytically active structure. Compositions for making MNAzymes, and collections of MNAzymes are... Agent: Philip S. Johnson Johnson & Johnson

20070231824 - Multiplex decoding of array sensors with microspheres: The invention relates to compositions and methods for multiplex decoding of microsphere array sensors.... Agent: Knobbe Martens Olson & Bear LLP

20070231803 - Multiplex pcr mixtures and kits containing the same: A multiplex PCR reaction mixture is provided. In one embodiment, the reaction mixture contains a plurality of primer pairs that bind to genomic DNA for producing predetermined amplification products of a range of different sizes, where each primer pair is at a concentration that is selected for production of a... Agent: Agilent Technologies Inc.

20070231805 - Nucleic acid assembly optimization using clamped mismatch binding proteins: Certain aspects of the present invention provide methods for increasing the fidelity of multiplex nucleic acid assembly reactions using one or more mismatch binding proteins. Aspects of the invention also provide kits, compositions, devices, and systems for enriching nucleic acid samples for nucleic acids containing correct sequences using clamped forms... Agent: Wolf Greenfield & Sacks, P.C.

20070231820 - P450 enzymes, nucleic acids encoding them and methods of making and using them: The invention is directed to polypeptides having P450 activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The P450 enzymes can be used to catalyze the hydrolysis of epoxides and arene oxides to their corresponding diols.... Agent: Verenium C/o Mofo S.d.

20070231801 - Predicting negative symptom change during drug treatment: A method for predicting a negative symptom change in a subject during drug therapy is provided. The method comprises isolating genomic DNA from a sample of the subject, and genotyping a T5988C marker of GRIN2B gene. A GRIN2B 5988 T/T genotype is predictive of a negative symptom improvement in the... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20070231794 - Process to detect binding events on an electrode microarray using enzymes: The present invention provides a process to detect binding events on an electrode microarray. A microarray is provided having addressable electrodes and two or more different types of capture complexes at sites corresponding to the electrodes. The capture complexes capture analytes. Enzymes are attached to form a reporter complex. Substrate... Agent: Combimatrix Corporation

20070231796 - Sensor and method for detection of a target substance: A sensor, in one configuration, includes a plurality of beads located in a channel. The beads are attached to a surface of the channel by a biological binding mechanism that can be selectively unbound in the presence of a target substance. A measurement system is configured and arranged to determine... Agent: Beyer Weaver LLP

20070231819 - Targeted and non-targeted gene insertions using a linear minimal element construct: The present invention provides nucleic acids and methods for disrupting genes within cells. The nucleic acids can be linear minimal elements that integrate into target cell genomes with high efficiency. The nucleic acids may be used to knock out specific genes or to increase expression of certain genes in a... Agent: LatimerIPLaw, LLP

20070231826 - Article and assembly for magnetically directed self assembly: An article for assembly includes a substrate, at least one receptor site disposed on the substrate and a patterned magnetic film. The patterned magnetic film includes at least one magnetic region, each magnetic region being disposed within one of the receptor sites. The patterned magnetic film comprises a material with... Agent: General Electric Company Global Research

20070231829 - Ig-assay: A method of the quantitative determination of an immunoglobulin (Ig) of a certain class (IgX) in a liquid sample comprising the step of forming a complex that comprises a ternary affinity complex in which IgX is sandwiched between two affinity reactants 1 and 2 (R1 and R2, respectively).... Agent: Fulbright & Jaworski L.l.p

20070231827 - Method for identifying drug targets by mass spectrometry: The present invention is an improved method for identifying in vivo protein targets, which bind specifically to a chemical compound. A sample is divided into two sets, to one of which a chasing compound is added. Two sets are then purified by affinity column, digested and labeled for mass spectrometry... Agent: Hualin Zhong

20070231830 - Method for identifying inhibitors of g protein coupled receptor signaling: This invention relates to methods for identifying peptides and other compounds which block G protein coupled receptor mediated signaling with high affinity and specificity. Assays developed in conjunction with these methods also are disclosed.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070231828 - Methods of predicting behavior of cancers: Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in prostate tumors, and determined to be associated with growth and proliferation of the cancer cells. Accordingly, methods are provided for treating a prostate cancer associated with elevated Hh pathway activity by reducing or inhibiting the Hh... Agent: Dla Piper US LLP

20070231831 - The human e3alpha ubiquitin ligase family: The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3α ubiquitin ligase. The invention also relates to vector, host cells, antibodies and recombinant methods for producing the polypeptide. In addition, the invention discloses therapeutic, diagnostic and research utilities for these... Agent: Marshall, Gerstein & Borun LLP

20070231834 - Blood test kit: A blood crossmatching apparatus, kit and methods for testing the compatibility of mammals for blood transfusion. Particulate layers in the apparatus allow nonagglutinated red blood cells to permeate through, while agglutinated red blood cells cannot. The apparatus also has a density solution layered above particulate layers. The density solution separates... Agent: Fraser Trebilcock Davis & Dunlap, P.C.

20070231835 - Proteomic screening for redox state dependent protein-protein interactions: This invention provides a modified yeast two-hybrid system in order to identify NO-dependent protein-protein interactions. Bait proteins implicated in apoptotic signaling pathways were used to identify NO-dependent interactions. The physiological relevance of these interactions is demonstrated by their occurrence and dependence on endogenous NO in mammalian cells, and by the... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070231837 - Method of assessing properties of mammalian cells, and method of diagnosing cancer using the same: A CDK profile including a ratio of specific activities of two cyclin dependent kinases closely correlates with the malignancy grade and the presence/absence of the sensitivity to an irritant such as an anticancer agent of a cancer tissue in clinical medicine. Therefore, the properties of a mammalian cell, such as... Agent: Sughrue Mion, PLLC

20070231836 - Screening assays for antioxidants and antiproliferative compounds: Provided are screening assays for identifying and evaluating compounds with antioxidant and/or antiproliferative activities.... Agent: J. Peter Fasse Fish & Richardson P.C.

20070231841 - Methods for altering acetic acid production and enhancing cell death in bacteria: Methods of increasing cultured cell growth yields and/or protein production from bacterial cell cultures are provided. More particularly, mutant bacterial cells having an alteration in the expression or activity of the cidABC operon, a gene therein, or a homolog or a regulator thereof, and methods for reducing acetic acid/acetate production... Agent: Klarquist Sparkman, LLP

20070231839 - Methods of treating or preventing an infectious disease using an immunogenic conjugate of a gram-negative bacterial autoinducer molecule or antibodies that immunospecifically bind a gram-negative bacterial autoinducer molecule: t

20070231840 - Spore specific antigen: The invention relates to a Bacillus spore specific antigen. Compositions and methods relating to the antigen are provided along with antibodies against the antigen. The antigen is specific for Bacillus spores relative to the vegetative form of the cells. The antigen is detectable on ungerminated spores. The antibodies may be... Agent: Townsend And Townsend And Crew, LLP

20070231832 - Device and methods for liquid crystal-based bioagent detection: The present invention provides liquid crystal-based devices and methods for bioagent detection. In certain aspects, the present invention is directed to devices and methods utilizing liquid crystals and membranes containing polymerized targets that can report the presence of bioagents including, but not limited to, enzymes, antibodies, and toxins.... Agent: Quarles & Brady LLP

20070231833 - Labeled antimicrobial peptides and method of using the same to detect microorganisms of interest: Labeled antimicrobial peptides and method of using the same to detect a microorganism of interest. In one embodiment, the method involves adding immuno-capture beads to a sample, the immuno-capture beads including capture antibodies coupled to a paramagnetic bead, the capture antibodies being specific for the type of microorganism of interest.... Agent: U.s. Army Soldier Systems Center

20070231842 - Detection of autoantibodies to cytokeratin 18 protein in patients with bronchial asthma and chronic rhinitis: The present invention is based on the surprising discovery of autoantibodies to cytokeratin 18 protein in the serum samples of patients with bronchial asthma and chronic rhinitis, especially in nonallergic patients. The present invention includes diagnostic methods and a diagnostic kit to detect patients with bronchial asthma and chronic rhinitis... Agent: The Rafferty Patent Law Firm

20070231843 - Antibodies for specifically detecting pathogenic prions of human origin, and detection methods carried out using these antibodies: This application includes description of antibodies for specifically detecting prions of human origin and methods for detecting pathogenic prions. In some embodiments, the antibodies bind to an epitope characteristic of a human prion protein which is not found in the prion proteins of other species. In some embodiments, the antibodies... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070231844 - Fast microbiological analysis method: The method includes the step of selecting a reagent adapted to reveal the presence of ATP by luminescence, the step of depositing said reagent on a support adapted to retain microorganisms and the step of detecting the response of said support to said reagent; said detection step includes the step... Agent: Nields & Lemack

20070231845 - Fast microbiological analysis method: The method of fast microbiological analysis of a support adapted to retain microorganisms includes the step of selecting a reagent adapted to reveal the presence of ATP, the step of acting on said microorganisms to render the ATP of said microorganisms accessible to said reagent, then the step of depositing... Agent: Nields & Lemack

20070231847 - Marker useful for detection and measurement of free radical damage and method: The present invention teaches a marker useful for detection and measurement of free radical damage. Specifically, the invention takes advantage of alterations which occur to the N-terminus of the albumin molecule, a circulating protein in human blood, in the presence of free radicals. These alterations effect the ability of the... Agent: Swanson & Bratschun, L.L.C.

20070231848 - Abeta-heme peroxidase: A β-heme peroxidase activity is selectively measured and inhibited, packaged as a pharmaceutical composition with heme biosynthetic cofactors or as an industrial enzyme, and used to oxidize target substrates.... Agent: Richard Aron Osman

20070231851 - Microfluidic device for cell separation and uses thereof: The invention features methods for separating cells from a sample (e.g., separating fetal red blood cells from maternal blood). The method begins with the introduction of a sample including cells into one or more microfluidic channels. In one embodiment, the device includes at least two processing steps. For example, a... Agent: Clark & Elbing LLP

20070231850 - Patterned cell network substrate interface and methods and uses thereof: There is provided herein a method and apparatus suitable for use in studying cell membrane related activities. Activities of interest include patch-clamp related studies of networks of cells on a solid substrate. Cells are grown, preferably in a patterned manner, on a substrate having microholes therein. Seals between the cells... Agent: National Research Council Of Canada 1200 Montreal Road

20070231849 - Process for identifying substances which modulate the activity of hyperpolarization-activated cation channels: The present invention provides a process for identifying substances that modulate the activity of hyperpolarization-activated cation channels, and the use of this process.... Agent: Ross J. Oehler Sanofi-aventis U.s. LLC

20070231853 - Methods of isolating bipotent hepatic progenitor cells: A method of obtaining a mixture of cells enriched in hepatic progenitors is developed which comprises methods yielding suspensions of a mixture of cell types, and selecting those cells that are classical MHC class I antigen(s) negative and ICAM-1 antigen positive. The weak or dull expression of nonclassical MHC class... Agent: Foley And Lardner LLP Suite 500

20070231854 - Mutant carotenoid ketolase: CrtW carotenoid ketolases are provided useful for the production of astaxanthin. The ketolases genes of the present invention exhibit improved ketolase activity when converting cyclic hydroxylated carotenoid intermediates into astaxanthin. Recombinant expression of the present carotenoid ketolases in host cell producing cyclic hydroxylated carotenoid intermediates enabled increased production of astaxanthin.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070231857 - Cloning and expression of gonadotropin-releasing hormone (gnrh) receptors: An isolated and purified GnRH protein receptor protein including an amino acid sequence selected from the group and an isolated and purified DNA which comprises a nucleotide sequence coding for the GnRH protein receptor protein. Also, a vector comprising the DNA of the GnRH protein receptor protein, a transformant carrying... Agent: Devine, Millimet & Branch, P.A.

20070231863 - Drg11-responsive axonal guidance and outgrowth of neurite (dragon) gene family: This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein. Protein and nucleic acid sequences of human, murine, zebrafish, and C. elegans Dragon family members are also disclosed.... Agent: Clark & Elbing LLP

20070231858 - Enzymatic preparation of (s) amino acid from (r,s) amino acid or from keto acid: Disclosed and claimed herein are novel biocatalysts for converting racemic mixtures of amino acids to an enantiomerically pure (S) form of the amino acid, methods for their use, and the enantiomerically enriched products of such biocatalytic processes.... Agent: Louis J. Wille Bristol-myers Squibb Company

20070231859 - Novel scavenger receptor: Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the elucidation of mechanisms of the development of a wide variety of diseases such as arteriosclerosis, diabetic complications and Alzheimer's disease, hyper... Agent: Marshall, Gerstein & Borun LLP

20070231860 - Over-expression of enzymes involved in post-translational protein modifications in human cells: Methods for producing and/or propagating virus particles that are present in a virus isolate obtained from an infected subject by contacting a host cell with a virus particle and culturing the cell under conditions conducive to propagation of the virus particle are disclosed. A method for selective propagation of a... Agent: Trask Britt

20070231862 - Peptide scaffolds for transfer of molecules into eukaryotic cells: Compositions and methods of using compositions with a nuclear targeting peptide containing a nonclassical nuclear localization signal to deliver selected molecules to the nucleus of eukaryotic cells are provided. The compositions are particularly useful in gene transfer methods.... Agent: Licata & Tyrrell P.C.

20070231861 - Production of isoprenoids: The invention provides a biological method of producing isoprenoids.... Agent: Sheridan Ross PC

20070231856 - Recombinant protein and polypeptide production using methylotropic or ethylotropic microorganisms with a dilute methanol or ethanol feeding: A method is provided for expressing recombinant proteins and polypeptides such as human serum albumin (HSA), human growth hormone (HGH), or insulin-like growth factor-I (IGF-1) in large quantities using a methylotropic or ethylotropic microorganism such as a yeast, bacteria or fungi using a dilute methanol or ethanol feeding strategy which... Agent: Stites & Harbison PLLC

20070231864 - Vanillin production: Novel compositions and methods for improving vanillin production in cultured Vanilla planifolia and in intact plants are provided. Transgenic cells and plants having improved vanillin production are also provided.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070231865 - Targeted deletions using retroelement-mediated placement of recombination sites: The present invention provides methods, nucleic acid constructs, and kits for selectively deleting a region of a nucleic acid sequence. Specifically, it utilizes retargeting retroelements to place site-specific recombination sites at targeted locations in the nucleic acid sequence. The region between the recombination sites is then deleted using a site-specific... Agent: Polsinelli Shalton Welte Suelthaus PC

20070231866 - Method for the preparation of k-carrageenase: Halophilic marine gram negative bacteria, isolated from decayed algae, hydrolyzed κ-carrageenan. To maximize κ-carrageenase production in the cost effective manner, a novel medium was defined having minimum components and their optimum concentration by statistical optimization method. Hence there evolved a novel medium composition for enhanced κ-carrageenase production by a new... Agent: Mcdermott Will & Emery LLP

20070231867 - P180 expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP

20070231868 - Nitrile hydratase: The present invention provides: a protein having an improved nitrile hydratase activity, whereby heat resistance has been improved when compared with a wild-type nitrile hydratase activity, wherein the amino acid sequence of a nitrile hydratase is modified; a gene DNA encoding the above protein; a recombinant vector having the above... Agent: Darby & Darby P.C.

20070231869 - Fermentation process, starter culture and growth medium: Ethanol production from biomass can be rendered more effective by the use of at least one fungus or a mix of fungi capable of fermenting pentose compounds, or both pentose as well as hexose compounds. Preferably said at least one fungus is a fungus belonging to the species Chalara sp.,... Agent: Morrison & Foerster LLP

20070231870 - Process for the upgrading of heavy crude oil, extra-heavy crude oil or bitumens through the addition of a biocatalyst: A process for the upgrading of heavy crude oil, extra-heavy crude oil or bitumens through the addition of a biocatalyst in the hydrocarbon flow, that includes the steps of: i) selecting the biological material for the preparation of the biocatalyst; ii) dispersing the biocatalyst in the flow of heavy crude,... Agent: Merchant & Gould PC

20070231871 - Process for an enzymatic oxygenation by direct electrochemical regeneration of the fad-dependent monooxygenase: Processes comprising oxygenating an educt to form a product in the presence of an FAD-dependent monooxygenase, wherein the FAD-dependent monooxygenase is regenerated by direct electrochemical reduction are described.... Agent: Connolly Bove Lodge & Hutz, LLP

20070231872 - System and method for collecting, storing, processing, transmitting and presenting very low amplitude signals: Methods and apparatus inject noise into a substance, detect the combination of the noise and the signal emitted by the substance, adjust the noise until the combination signal takes on the characteristic of the signal generated by the substance through stochastic resonance, and apply such characteristic signals to responsive chemical,... Agent: Perkins Coie LLP Patent-sea

20070231873 - Multi-channel electroporation system: Systems, methods and apparatus provide flexible and efficient high throughput electroporation systems. An electrical pulse may be transmitted to any number of channels of a multi-channel sample plate. Drivers can provide the selection of which channels to transmit the electrical pulse. To provide efficient transitions between electrical pulses, discharge circuits... Agent: Townsend And Townsend And Crew, LLP

20070231874 - Crystal of glucokinase protein, and method for drug design using the crystal: Glucokinase is crystallized, the three-dimensional structure thereof is analyzed, and then a compound to be bonded to glucokinase is designed on the basis of the coordinate for the resulting three-dimensional structure. Specifically, glucokinase is freed of a part of amino acid residues being on the N-terminal side thereof, to thereby... Agent: Merck And Co., Inc

20070231875 - Apparatus for the disruption of animal cells: The present invention relates to the field of purifying recombinant virus propagated in animal cells. More particularly, it relates to a method for extracting virus from virus-infected cells that have been grown in culture in order to release virus and to apparatus for extracting virus from virus-infected cultured cells using... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20070231876 - Purification process for bacterial cytolysin: The present application relates to a process for purification of a bacterial cytolysin comprising the steps of a) growing a culture of cells expressing bacterial cytolysin, b) mechanically breaking the culture of cells to form an extract, c) prefiltering the extract, d) binding soluble aggregated bacterial cytolysin contained in the... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20070231877 - Systems and processes for treatment of organic waste materials with a biomixer: Waste material is screened to produce unders and overs, the overs are treated to produce a partially hydrolyzed biomass, and the partially hydrolyzed biomass and the unders are anaerobically digested. Treating the overs includes fermenting and mixing the overs with an aerotolerant anaerobic bacteria in a controlled environment, such as... Agent: Carr & Ferrell LLP

20070231878 - Collagen of fish scale and method of making thereof: This invention discloses a method for making collagen of fish scale, and more specifically it relates to a method of using enzyme to extract collagen of fish scale, the method comprising: washing and heating the fish scale material; smashing the fish scale material; adding the protein hydrolase into the fish... Agent: Pai Patent & Trademark Law Firm

20070231879 - Perfusion device for the treatment and examination of an object in a liquid: A perfusion device (10) is described, particularly for electro-physiological and/or optical examinations on biological objects (1) which comprises a chamber body (20) in which a perfusion chamber (21, 25) is formed with at least one input opening (22, 23) and at least one discharge (24), and a holding device (30)... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070231881 - Biomolecular interaction analyzer: Obtained is a biomolecular interaction analyzer which is capable of simultaneously measuring a large number of many kinds of samples. The biomolecular interaction analyzer is an analyzer for measuring biomolecular interactions, which includes a measurement chip and a color CCD array. The measurement chip includes a plurality of measurement areas... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070231882 - Measurement apparatus and element for analysis: The production amount of thiol compounds which is the product of the cyclic reaction of enzyme-labeled antibody, or the production rate thereof is measured as an adsorption rate on a gold electrode formed on an insulated gate field-effect transistor. The adsorption rate is measured by monitoring in real time the... Agent: Mattingly, Stanger, Malur & Brundidge, P.C.

20070231883 - Flourescence reader: Fluorescence reader (10) for an optical assay arrangement comprising a polymeric sample substrate (1) having a reaction site-surface and a substrate surface (3), the fluorescence reader comprising a light source (5) arranged to illuminate the reaction site-surface through the substrate surface, and a detector device (6) arranged to detect fluorescent... Agent: Morrison & Foerster LLP

20070231880 - Microfluidic interface for highly parallel addressing of sensing arrays: Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps... Agent: Trask Britt

20070231884 - Porous body and producing method thereof: According to a producing method including; preparing a foaming slurry by agitating and blending a dispersion medium containing hollow glass or ceramic particles having an average particle diameter of 1 μm or more, a dispersant and a foaming agent to foam; obtaining a dried body by dropping the foaming slurry... Agent: Foley And Lardner LLP Suite 500

20070231885 - Biomechanical device for producing a biomass: A rotating drum is provided for the biological/mechanical conversion of organic waste material to a valuable biomass. An aerotolerant anaerobic bacteria within the rotating drum promotes the fermentation of the waste material, while the tumbling of the waste material due to the rotation of the drum mechanically shears the waste... Agent: Carr & Ferrell LLP

20070231886 - Reactor plant and process for culturing phototropic microorganisms: Reactor plant and process for culturing phototropic microorganisms with a reactor vessel and a photosynthetic module, which are connected with one another in a circulation circuit by a pump and can be controlled via a control unit, where in the circulation circuit or in the reactor vessel, a homogenizer is... Agent: Casella & Hespos

20070231887 - Cell culture devices having ultrathin porous membrane and uses thereof: Disclosed is a device for co-culturing two or more populations of cells using ultrathin, porous membranes positioned between cell culture chambers. Multiple chamber devices and uses thereof are described, including the formation of in vitro tissue models for studying drug delivery, cell-cell interactions, and the activity of low abundance molecular... Agent: Nixon Peabody LLP - Patent Group

20070231889 - In situ heat induced antigen recovery and staining method: An automated in situ heat induced antigen recovery and staining method and apparatus for treating a plurality of microscope slides. The process of heat induced antigen recovery and the process of staining the biological sample on the microscope slide are conducted in the same apparatus, wherein the microscope slides do... Agent: Dunlap, Codding & Rogers P.C.

20070231888 - Semi-continuous blood separation using magnetic beads: A container having a flexible wall receives a continuous flow of a biological fluid that includes a target antigen and emits a continuous flow of the biological fluid at least partially depleted from the target antigen. The container further comprises a compartment with magnetic beads coupled to an affinity marker... Agent: Fish & Associates, PC Robert D. Fish

20070231892 - Isolation of nucleic acids: A method for extracting nucleic acids from a biological material such as blood comprises contacting the mixture with a material at a pH such that the material is positively charged and will bind negatively charged nucleic acids and then eluting the nucleic acids at a pH when the said materials... Agent: Invitrogen Corporation C/o Intellevate

20070231890 - Ribonucleases and methods of making them recombinantly: Methods for recombinantly producing new RNases, as well as previously-known RNases, are disclosed. The new RNases are active against human carcinoma cells.... Agent: Mark H. Jay, P.A.

20070231891 - Ribonucleases and methods of making them recombinantly: Methods for recombinantly producing new RNases, as well as previously-known RNases, are disclosed. The new RNases are actable against human carcinoma cells.... Agent: Mark H. Jay, P.A.

20070231894 - Flea ultraspiracle nucleic acid molecules: The present invention relates to flea ecdysone receptor and ultraspiracle proteins; to flea ecdysone receptor and ultraspiracle nucleic acid molecules, including those that encode such flea ecdysone receptor and ultraspiracle proteins; to antibodies raised against such flea ecdysone receptor and ultraspiracle proteins; and to compounds that inhibit flea ecdysone receptor... Agent: Heska Corporation Intellectual Property Dept.

20070231893 - Novel chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070231895 - Methods for adapting mammalian cells: Methods of adapting cells, e.g., mammalian cells, to a cell culture process are provided. When the adapted cells are genetically modified and used for protein production, they exhibit beneficial characteristics, such as being able to attain higher cell densities and/or achieve a higher overall yield of the produced protein.... Agent: Choate, Hall & Stewart LLP/wyeth

20070231897 - Induction of insulin secreting cell: Disclosed is a method for producing insulin secreting cells to be used in cell transplantation therapy of diabetes, by induction from pancreatic acinar cells in culture vessels. The method comprises culturing pancreatic acinar cells isolated from a mammal in a medium containing a growth factor, preferably epidermal growth factor, fibroblast... Agent: Millen, White, Zelano & Branigan, P.C.

20070231896 - Use of il-17-for maturation of oocytes: The use of IL-17 for the in vitro maturation of mammalian oocytes is described. The in vitro matured oocytes may be used for in vitro fertilization protocols.... Agent: Howrey LLP

20070231898 - Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury: This invention provides populations of neural cells bearing markers of glial cells, such as oligodendrocytes and their precursors: The populations are generated by differentiating pluripotent stem cells such as human embryonic stem cells under conditions that promote enrichment of cells with the desired phenotype or functional capability. Various combinations of... Agent: Bozicevic, Field & Francis LLP

20070231899 - Compositions and methods for inhibiting tumor growth and metastasis: Disclosed are compositions and methods useful in the reduction of p11 protein activity in cancer cells. P11 protein is demonstrated to affect plasmin production and activity, MMP activity, plasminogen activation, antiangiogenic plasmin fragment production, cell invasion, tumor development and metastasis. Compositions that modulate levels of p11 either up or down... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20070231900 - Biocompatible, biodegradable polymer-based, lighter than or light as water scaffolds for tissue engineering and methods for preparation and use thereof: Scaffolds for tissue engineering prepared from biocompatible, biodegradable polymer-based, lighter than or light as water microcarriers and designed for cell culturing in vitro in a rotating bioreactor are provided. Methods for preparation and use of these scaffolds as tissue engineering devices are also provided.... Agent: Licata & Tyrrell P.C.

20070231901 - Microfluidic cell culture media: A microfluidic cell culture media may have an initial concentration of an active material less than a therapeutic window of concentration necessary to provide a cellular mass a therapeutic environment.... Agent: Brooks Kushman P.C.

20070231902 - Use of esters of unsaturated, physiologically active fatty acids as nutrient media for cell cultures: The disclosed invention relates to the use of esters of unsaturated, physiologically active fatty acids as nutrient media for cell cultivation and, more particularly, as a substitute for foetal bovine serum. In one aspect, the esters comprise more than 50 mol-% of physiologically active fatty acids containing 16 to 24... Agent: Cognis Corporation Patent Department

20070231903 - Compositions and methods for plant improvement: The invention provides compositions and methods useful for producing plant cells or plants with altered tolerance to at least one environmental stress selected from drought, cold, freezing, heat and salinity.... Agent: Knobbe Martens Olson & Bear LLP

20070231904 - Nucleic acid sequences encoding cel ii endonuclease: The present invention relates to isolated nucleic acid sequences encoding CEL II endonuclease and vectors and host cells for producing a protein encoded thereby.... Agent: Licata & Tyrrell P.C.

20070231905 - Methods for improving seed characteristics: Methods are provided for altering grain characteristics by introducing into plants, isolated nucleic acid molecules that can be used to produce transgenic plants characterized by altered number, type, or configuration of aleurone cells within the seed. Also provided are isolated nucleic acids that encode maize superal proteins, vectors capable of... Agent: Pioneer Hi-bred International, Inc.

20070231906 - Three frame cdna expression libraries for functional screening of proteins: Compositions and methods are provided for generating three frame cDNA expression libraries for functional screening of proteins. The invention includes sets of 5′ adapters for cloning cDNA molecules in which the sets include three adapters that can be used to clone a particular cDNA in all three reading frames. The... Agent: Invitrogen Corporation C/o Intellevate

20070231907 - Methods for directing dna methylation in mammalian cells using homologous, short double stranded rnas: The invention provides methods for methylating a gene of interest in a cell. The methods include exposing a mammalian cell to an siRNA molecule which is specific for a gene of interest in the cell. The methods also include introducing into the cell DNA sequences encoding a sense strand and... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070231908 - Nanospearing for molecular transportation into cells: A nanostructured molecular delivery vehicle comprising magnetic materials and configured to receive passenger biomolecules. The application of a an appropriate magnetic field having a gradient orients and drives the vehicle into a biological target, which may comprise cells, cell masses, tissue slices, tissues, etc. Under the control of the magnetic... Agent: Pandiscio & Pandiscio, P.C.