Chemistry: molecular biology and microbiology inventions 09/07

20070224603 - Cleavable linkers for polynucleotides: In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.... Agent: Agilent Technologies Inc.

20070224597 - Isolating fetal trophoblasts: Methods for isolating and purifying fetal trophoblasts from a mucus sample obtained from the uterine cavity of a pregnant female. The mucus sample is transported from a clinical collection facility to a laboratory in a transportation medium so the cells remain viable. The mucus sample is then subjected to precise... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070224616 - Method for forming molecular sequences on surfaces: A method for forming molecular sequences includes derivatizing an unconfined substrate surface with at least one linker containing a protected reactive group. The substrate is contacted with a solution containing a photogenerated reagent precursor and a buffer and/or a neutralizer. A photogenerated reagent is generated in at least a portion... Agent: Julia Church Dierker Dierker & Associates, P.C.

20070224602 - Thiocarbonate linkers for polynucleotides: In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.... Agent: Agilent Technologies Inc.

20070224646 - Method for estimating protein-protein binding affinities:

20070224652 - Blood group antigens of different types for diagnostic and therapeutic applications: The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing.... Agent: Ivor Elrifi, Esq. Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20070224657 - Distribution of pon1 as a marker of lipid related disorders: A method of diagnosing a subject with a lipid related disorder is disclosed, the method comprising determining an amount or activity of PON1 or apo-A1 in an LPDS fraction of a serum of the subject, wherein an amount or activity of PON1 above a predetermined threshold is indicative of the... Agent: Martin D. Moynihan Prtsi, Inc.

20070224587 - Allograft packaging system: An allograft method and apparatus for providing and allograft package package comprised of a sponge having an internal cavity for containing an allograft and a sealable container for enclosing the sponge and maintaining the environment established at the time of closure of the sealed container.... Agent: Bruce & Mccoy

20070224589 - Protection of biologically active molecules using amphiphiles: A process for the protection of a biologically active compound against the effect of for instance enzymes, chemicals, oxygen, radicals or sunlight. The process is characterized in comprising the step of bringing the biologically active compound in contact with at least one SAINT-molecule. Thereby a good protection from the biologically... Agent: Peacock Myers, P.C.

20070224588 - Trophoblast preservation/pretreatment medium and method: An aqueous preservation medium for the selective preservation of trophoblasts obtained in a sample of cervical mucus which permits transportation of such sample to a laboratory facility for analysis and selectively preserves fetal trophoblasts in said sample while presenting conditions that are antagonistic to many maternal cells.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070224591 - Rotation-based microsampler, system and method of using the same: A microsampler disc for use in the analysis of agents is described as including a plurality of microstructures configured and spaced to promote movement of a fluidic medium containing agents radially outwardly and promote filtering of one species of agents from other species of agents. An analysis system using the... Agent: General Electric Company Global Research

20070224590 - Single cell planar chromatography: A system for preparing a biological cell for analysis comprising the deposition of the biological cell on a planar chromatographic support medium and lysis of the biological cell. In one embodiment, the present invention includes one or two dimensional chromatography of the biological cell. One embodiment of the present invention... Agent: Eddie E. Scott Assistant Laboratory Counsel

20070224594 - Detection of influenza virus: The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or... Agent: Townsend And Townsend And Crew, LLP

20070224593 - Diagnosis of transmissible spongiform encephalopathy: The invention features a method of diagnosing or providing a prognosis regarding the state of Transmissible Spongiform Encephalopathies (TSEs) in a mammal by contacting a target tissue or other environmental sample with a detectable compound, which binds to a non-amyloid form of a disease specific prion (PrP-d). An increase in... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070224619 - Apolipoprotein e genotyping and accompanying internet-based health management system: The invention provides a system for monitoring a patient that includes: 1) a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo B information; 2) a database that receives and stores the patient's Apo E information; and 3) an Internet-based system... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070224620 - Compositions and methods for capturing and analyzing cross-linked biomolecules: Methods, compositions and kits to capture cross-linked protein complexes to a support matrix in a stable, covalent bridge of attachment are provided.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20070224596 - Compositions and methods for the modifying hypoxia induced gene regulation: This invention provides compositions and methods to identify candidate agents capable of altering the biological activity of a polypeptide encoded by a polynucleotide involved in hypoxia-related tumorigenesis. In one aspect, the biological activity is the induction of hypoxia-related gene enolase 2 or a biological equivalent thereof. In another aspect, the... Agent: Genzyme Corporation Legal Department

20070224630 - Compositions and methods of selective nucleic acid isolation: The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070224614 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent: Medlen & Carroll LLP

20070224612 - Compounds and methods for nucleic acid mismatch detection: In accordance with the present invention there are provided sterically demanding intercalators. These compounds are useful for detection of a base-pair mismatch, such as by measuring fluorescence of complexes formed by the compounds of the invention and nucleic acid duplexes. The compounds are also capable of catalyzing photolytic cleavage of... Agent: Dla Piper US LLP

20070224626 - Comprehensive dna methylation profiling in a human cancer genome identifies novel epigenetic targets: The present invention provides DNA marker sequences that are differentially methylated in samples from normal individuals and individuals with brain cancer. The invention further provides methods of identifying differentially methylated DNA marker sequences and their use the detection and diagnosis of gliomas.... Agent: Townsend And Townsend And Crew, LLP

20070224631 - Device and method for high-throughput quantification of mrna from whole blood: Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to oligo(dT)-immobilized multi-well plates.... Agent: Knobbe Martens Olson & Bear LLP

20070224632 - Device and method for high-throughput quantification of mrna from whole blood: Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to oligo(dT)-immobilized multi-well plates.... Agent: Knobbe Martens Olson & Bear LLP

20070224627 - Facilitation of translocation of molecules through the gastrointestinal tract: The invention concerns methods and means for facilitating the translocation of molecules through the gastrointestinal tract of mammals. In particular, the invention concerns methods for identifying antibodies, including antibody fragments, capable of translocation from the lumenal side of gastrointestinal tissue into the blood stream or into the lymphatic circulation. The... Agent: Heller Ehrman LLP

20070224609 - Genotoxic testing: The present invention relates to methods for detecting for the presence of an agent that putatively causes or potentiates DNA damage comprising subjecting a cell (containing a DNA sequence encoding a reporter protein operatively linked to a human GADD45α gene promoter and a human GADD45α gene regulatory element arranged to... Agent: Gates & Cooper LLP Howard Hughes Center

20070224611 - Inactivation method: The present invention relates to the field of thermostable enzymes, methods for their inactivation, and related uses, kits and reagents. In particular, the invention relates to a method for reversible inactivation of thermophilic enzymes by chemical modification under aqueous or non-aqueous conditions.... Agent: Buchanan, Ingersoll & Rooney PC

20070224599 - Interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: People with the SS variant of the human serotonin transporter gene are more susceptible to episodes of major depression when faced with mildly threatening life events than people with the SL or LL variants. Methods for identifying and treating such patients are provided.... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070224629 - Laser exposure of photosensitive masks for dna microarray fabrication: A method and apparatus for forming a polymer array on a substrate suitable for synthesizing polymer sequences. This includes forming an array, each location of the array having at least one strand end, forming photosensitive protection on the strand ends, and selectively scanning and modulating at least one energy beam... Agent: Intel/blakely

20070224613 - Massively multiplexed sequencing: The present invention provides multiplexed methods for analyzing polynucleotides associated with sample tags. The multiplexed information is deconvoluted by single-molecule and more generally single-particle detection methods. In particular, a method for determining nucleic acid sequence information is provided.... Agent: Michael Strathmann

20070224617 - Mechanically induced trapping of molecular interactions: The invention provides devices and methods for surface patterning the substrate of a microfluidic device, and for detection and analysis of interactions between molecules by mechanically trapping a molecular complex while substantially expelling solvent and unbound solute molecules. Examples of molecular complexes include protein-protein complexes and protein-nucleic acid complexes.... Agent: Townsend And Townsend And Crew, LLP

20070224618 - Method for determining protein solubility: The present invention relates to methods of screening for expression of a soluble candidate protein within an expression library of candidate proteins. The method involves fusing each candidate protein in the library to a peptide substrate and identifying cells that express soluble candidate protein by detecting enzymatic modification of the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070224605 - Method for preparing a dna chip and use thereof: The present invention relates to a method for producing a DNA chip, which comprises the steps of: (a) cloning a probe, where a linker is coupled to one or both ends of an oligonucleotide to be integrated on a slide, into a vector; (b) transforming host cells with the vector;... Agent: Intellectual Property / Technology Law

20070224604 - Method of determining the presence and/or concentration of substances of interest in fluids: Magnetic particles coated with specific antibodies for substances of interest are introduced into a fluid sample. Over time and with agitation, the magnetic particles become attached to the substance of interest within the fluid. The fluid is then introduced to a magnetic field gradient provided between two magnets (1, 5).... Agent: Kaplan Gilman Gibson & Dernier L.L.P.

20070224610 - Method of quantifying hiv-1 rna-dna hydrid and diagnosis kit: A diagnostic kit for evaluating the progress of an HIV-1-related disease and/or the efficacy of an anti-HIV-1 treatment using the quantity of an HIV-1 RNA-DNA hybrid in a sample as an indicator, comprising: at least one primer pair consisting of a downstream primer having a sequence complementary to a portion... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070224615 - Methods for assaying protein-protein interactions: The invention relates, in part, to methods for detecting, monitoring, measuring or assessing an interaction between at least two proteins. The invention also relates, in part, to methods for determining if a test compound, or a mix of compounds, modulates an interaction between at least two proteins. In some embodiments,... Agent: Invitrogen Corporation C/o Intellevate

20070224600 - Methods for diagnosing and treating kidney and colorectal cancer: Methods, reagents and kits for diagnosing and treating cancer such as kidney or colorectal cancer are disclosed. An immunoassay for detecting kidney or colorectal cancer is based on the relative change of the ADAMTSL4 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney or... Agent: Perkins Coie LLP

20070224607 - Methods for identifying compounds of interest using encoded libraries: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.... Agent: Lahive & Cockfield, LLP

20070224606 - Mn/ca ix/ca9 and renal cancer prognosis: Herein disclosed are methods that are prognostic for renal cell carcinoma, particularly renal clear cell carcinoma, afflicting a vertebrate. An exemplary prognostic method comprises detecting the presence of, and quantitating the level and/or extent of a MN/CA9 gene expression product in a sample from the affected subject, wherein if 50%... Agent: Leona L Lauder Law Offices Of Leona L Lauder

20070224624 - Nucleic acid encoding spinocerebellar ataxia-2 and products related thereto: The present invention provides isolated nucleic acids encoding human SCA2 protein, or fragments thereof, and isolated SCA2 proteins encoded thereby. Further provided are vectors containing invention nucleic acids, probes that hybridize thereto, host cells transformed therewith, antisense oligonucleotides thereto and compositions containing antibodies that specifically bind to invention polypeptides, as... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070224595 - Nucleic acid molecules and other molecules associated with plants: Expressed Sequence Tags (ESTs) isolated from wheat are disclosed. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The disclosed ESTs have utility in the development of new strategies for understanding critical plant developmental and metabolic pathways. The disclosed... Agent: Lawrence M. Lavin, Jr. Monsanto Company

20070224622 - Plant chimeric binding polypeptides for universal molecular recognition: Libraries of nucleic acids encoding chimeric binding polypeptides based on plant scaffold polypeptide sequences. Also described are methods for generating the libraries.... Agent: Fish & Richardson PC

20070224628 - Protein isoform discrimination and quantitative measurements thereof: The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents to identify the isoforms to be detected/measured.... Agent: Goodwin Procter LLP Patent Administrator

20070224601 - Quantification of depurination through the use of two cleavage sites: The invention is directed an array comprising at least one depurination probe including a depurination sensitive first cleavage site adjacent a first tag region; and a base-cleavable second cleavage site adjacent a second tag region wherein the first tag region and the second tag region are independently quantifiable upon release... Agent: Agilent Technologies Inc.

20070224608 - Recombinant 12-kda protein useful for the detection of respiratory allergies: The present invention discloses the detection of an important 12K-Da protein having cross-reactivity amongst different prevalent allergenic grasses and fungi can be useful for detection of respiratory allergies. Conventionally, the whole extracts that are used for diagnosis are unable to specifically detect the causative agents. In addition, they are also... Agent: Birch Stewart Kolasch & Birch

20070224621 - Sequential reporter enzyme luminescence (srl) methods and compositions for practicing the same: Sequential reporter enzyme luminescence (SRL) methods are provided. In the subject methods, the activity of a reporter enzyme is evaluated using a secondary reporter system that employs a product of a reporter enzyme mediated reaction as a luminescent substrate, e.g., luciferase substrate. Also provided are kits and other compositions that... Agent: Bozicevic, Field & Francis LLP

20070224623 - Simplified qtl mapping approach for screening and mapping novel markers associated with beef marbling: Particular aspects provide an inexpensive QTL mapping approach for genome-wide scans of QTL linked markers and for narrowed locations of QTL regions, which may comprise integration of the amplified fragment length polymorphism (AFLP) with DNA pooling and selective genotyping and comparative bioinformatics tools. AFLP simultaneously screens high numbers of loci... Agent: Frommer Lawrence & Haug

20070224625 - Site-specific enzymatic deposition of metal in situ: The present invention provides compositions, kits, assembles of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In particular, the invention relates to use of enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also... Agent: Wilson Sonsini Goodrich & Rosati

20070224598 - System and method for detection of mutations in jak2 polynucleotides: Disclosed are a system and methods for identifying JAK2-specific polynucleotide sequences in a biological sample. Also disclosed are oligonucleotide primer and probe comopositions for detecting mutations in a JAK2 polynucleotides, and the JAK2V617F mutation in specific, as well as systems, diagnostic kits and articles of manufacture comprising JAK2-specific primer and... Agent: Haynes And Boone, LLP

20070224642 - Analytical method for protein mapping using hydrogen/deuterium exchange: Analytical methods using hydrogen/deuterium exchange are provided which reduce or eliminate the back-exchange of deuterium for hydrogen. The methods, which are useful in protein and peptide mapping, include the steps of (a) providing a peptide or protein comprising a solvent accessible hydrogen; (b) exchanging the solvent accessible hydrogen for a... Agent: Sutherland Asbill & Brennan LLP

20070224641 - Apparatus and method for ziegler-natta research: A combinatorial method for identifying a catalyst composition for use in the heterogeneous Ziegler-Natta addition polymerization of an olefin monomer, said catalyst composition comprising a compound of a metal of Group 2 of the Periodic Table of the Elements.... Agent: The Dow Chemical Company

20070224640 - Device and method for protein analysis: A device for protein analysis or mapping, includes an array of particulate nanoparticles, wherein said nanoparticles are bound, preferably co-immobilized, at specific spots on a planar read-out surface or substrate and are provided with a plurality of capture probes for capturing proteins, preferably glycoproteins. A method in which the device... Agent: Young & Thompson

20070224643 - Methods and compositions for the diagnosis of diseases of the aorta: The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to the use of biomarkers, either individually or in combinations with one another to rule in or out diseases of the aorta and its branches,... Agent: Foley & Lardner LLP

20070224634 - Methods for detecting l-ficolin dependent activation of the lectin pathway of complement and kits therefor: The invention provides methods, assays and kits for detecting L-ficolin dependent activation of the lectin pathway of complement and for identifying L-ficolin abnormalities. Also provided are methods for detection of gram positive bacteria based on the interaction between L-ficolin complexes and LTA.... Agent: Morrison & Foerster LLP

20070224633 - Muteins of tear lipocalin: The present invention relates to novel muteins derived from tear lipocalin or a homologue thereof. In particular, the invention relates to a mutein of human tear lipocalin. The invention also refers to a corresponding nucleic acid molecule encoding such a mutein and to a method for its generation. The invention... Agent: Foley And Lardner LLP Suite 500

20070224645 - Novel cell-based phosphodiesterase assays: The present invention relates to improved cell-based assays for the in vivo assessment of phosphodiesterase (PDE) activity using cyclic nucleotide-gated channels as cyclic nucleotide sensors, and for the assessment of the effect of PDE modulating compounds.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070224644 - Ocular fluid markers: The present invention relates to the analysis and monitoring of ocular fluids for determining the physiological state of an organism, to monitor drug efficacy and dynamics, for early disease detection, as well as to certain molecular markers and fingerprints of identified molecules or molecule fragments in such analysis.... Agent: Millen, White, Zelano & Branigan, P.C.

20070224637 - Oxidative protection of lipid layer biosensors: The present invention provides methods and composition related to lipid layers with increased stability to oxidative degradation. In one embodiment, the invention provides lipid layers comprising antioxidant inclusion molecules that permit biosensors with increased performance and functional lifetime due to increased oxidative protection. In addition to these lipid-layer compositions, the... Agent: Howrey LLP

20070224636 - Pyrrolo[1,2b]pyridazine compounds and their uses: e

20070224635 - Regulated stop codon readthrough: Methods for screening or selecting cells expressing a polypeptide of interest, e.g. for selecting cells expressing a desired level of a polypeptidé of interest, for evaluating recombinant polypeptide expression in a population of cells, or for selecting cells expressing a polypeptide with a desired binding affinity to a ligand, as... Agent: Maxygen, Inc. Intellectual Property Department

20070224638 - Secreted proteins as early markers and drug targets for autoimmunity, tumorigenesis and infections: The present invention relates to a method for the early diagnosis of a disease having a pre-inflammatory phase, or for the diagnosis of a predisposition to said disease, in a mammal, prior to any clinical signs, comprising measuring the level of at least a marker protein chosen amongst the following... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070224639 - Substrate for immobilizing biomolecules, biochip, and biosensor: A substrate for immobilizing biomolecules comprises a chip substrate, a hydrophilic monolayer, and a lipid bilayer, and a biochip comprising the substrate for immobilizing biomolecules on which biomolecules are immobilized. The substrate for immobilizing biomolecules includes a transparent chip substrate, a metal layer provided on the chip substrate, a monolayer... Agent: Osha Liang L.L.P.

20070224648 - Methods and compositions for the diagnosis of treatment of type 2 diabetes: Methods and compositions for the modulation of insulin secretion.... Agent: Marshall, Gerstein & Borun LLP

20070224647 - Monitor protein for measuring processing of protein: A monitor protein for measuring processing of a protein comprising a processing region which contains an amino acid residue or an amino acid residue sequence to be processed and a secretory chimeric protein which originates in the stereostructure of a protein containing at least a processing region formed by the... Agent: Knobbe Martens Olson & Bear LLP

20070224651 - Reduction of platelet interference in plasma assay samples: The present invention relates to compositions for improving assay accuracy for plasma samples by decreasing or eliminating false results due to platelet interference. The compositions of the present invention comprise compositions that include a platelet interference reducing agent in an amount effective to decrease the platelet interference activity in the... Agent: Woodcock Washburn LLP

20070224650 - Systems and methods for screening for modulators of neural differentiation: The present invention provides in vitro systems for use in identifying modulators of neural differentiation. Also provided are modulators identified by these systems. The present invention further provides methods for identifying a modulator of neural differentiation, a modulator of an FGF signalling pathway, a modulator of FGF-dependent neural differentiation, a... Agent: Baker Botts L.L.P.

20070224653 - Methods for modulating an immune response by modulating krc activity: This invention demonstrates that KRC molecules have multiple important functions as modulating agents in regulating a wide variety of cellular processes including: inhibiting NFkB transactivation, increasing TNF-alpha induced apoptosis, inhibiting JNK activation, inhibiting endogenous TNF-alpha expression, promoting immune cell proliferation and immune cell activation (e.g., in Th1 cells and/or Th2),... Agent: Lahive & Cockfield, LLP

20070224649 - Novel scavenger receptor: Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the elucidation of mechanisms of the development of a wide variety of diseases such as arteriosclerosis, diabetic complications and Alzheimer's disease, hyper... Agent: Marshall, Gerstein & Borun LLP

20070224654 - Method of detecting an antibody in a liquid sample: v

20070224655 - Methyltransferase assays: The present invention relates to coupled enzyme assays. In particular, the present invention provides a coupled fluorescent assay for detection of S-adenosylmethionine (AdoMet)-dependent methyltransferase activity.... Agent: Medlen & Carroll, LLP

20070224656 - Modulation of abeta levels by beta-secretase bace2: The present invention is based on the findings that BACE2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of Aβ. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique... Agent: Morrison & Foerster LLP

20070224658 - Cell growth: The present invention relates to use of peptide containing and peptide free synthetic low density lipoprotein (sLDL) particles as cell growth supplements for the growth of eukaryotic cells, especially mammalian.... Agent: Alston & Bird LLP

20070224659 - Harmful substance evaluating method and harmful substance evaluation kit: A biological growth inhibition factor assay method includes: a first step of mixing a photosynthetic sample, with an aqueous solution sample to prepare a test measurement solution, letting the test measurement solution stand, and then after illuminating light onto the test measurement solution for a predetermined illumination time, measuring the... Agent: Drinker Biddle & Reath (dc)

20070224660 - Method for assessment of cytotoxic t lymphocyte activity: A new cytotoxic T lymphocyte (CTL) assay has been discovered using two cell lines that stably express either green fluorescent protein (GFP) or red fluorescent protein (DsRed), which are distinguishable by FACS, fluorescence microplate reader, or fluorescence microscopy. Using one cell line as a target (T) to present antigen and... Agent: Patent Department Taylor, Porter, Brooks & Phillips, L.l.p

20070224663 - Human secreted proteins: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors,... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070224661 - Method for producing unsaturated omega-3-fatty acids in transgenic organisms: The present invention relates to a process for production of unsaturated ω-3-fatty acids and to a process for production of triglycerides with an elevated content of unsaturated fatty acids, especially of ω-3-fatty acids having more than three double bonds. The invention relates to the production of a transgenic organism, preferably... Agent: Connolly Bove Lodge & Hutz, LLP

20070224662 - Post-translational modification of proteins in cell-free expression systems: Disclosed is a method for post-translational modification of a recombinant protein in a cell-free expression system. The method comprises co-expressing the enzyme responsible for the post-translational modification along with the target protein in a prokaryotic based in vitro expression system. In one embodiment the expression system further comprises a eukaryotic... Agent: Roche Diagnostics Operations Inc.

20070224665 - Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated... Agent: Fish & Richardson, PC

20070224664 - System for antibody expression and assembly: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can... Agent: Merchant & Gould PC

20070224666 - Alleles of the zwf gene from coryneform bacteria: The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.... Agent: Law Office Of Michael A. Sanzo, LLC

20070224667 - Method of making theanine: In a method of making theanine, glutaminase is derived from microbes of one or more of Bacillus, mold and yeast is caused to act on glutamine and ethylamine derivative.... Agent: Burr & Brown

20070224668 - Process for producing 4-vinylguaiacol by biodecaroxylation of ferulic acid: 4-vinylguaiacol is produced using recombinant E. coli containing a decarboxylase gene from Bacillus pumilis in an aqueous fermentation broth and in an immobilized whole cell system. The 4-vinylguaiacol is extracted and recovered from an organic hydrocarbon solvent, preferably n-octane, whereby the product can readily be separated.... Agent: George A. Seaby Seaby & Associates

20070224669 - Self-pressurizing, self-purifying system and method for methane production by anaerobic digestion: Methane is produced using self-pressurizing, self-purifying system (2) and method, which converts a biomass into a biogas using anaerobic digestion. The anaerobic digestion is conducted in a bioreactor (4) that is maintained at a near constant pressure. The biogas that is generated is separated into a non-methane gas and a... Agent: Jones, Tullar & Cooper, P.C.

20070224670 - Chondroitinase abc i and methods of production: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans... Agent: Wolf Greenfield & Sacks, P.C.

20070224671 - Inhibitors of serine protease activity methods and compositions for treatment of nitric oxide-induced clinical conditions: A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having... Agent: Don D. Cha

20070224672 - Method of identifying inhibitors of dhodh: The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable... Agent: Womble Carlyle Sandridge & Rice, PLLC Attn: Patent Docketing 32nd Floor

20070224673 - Proteases and variants thereof: The present invention relates to isolated proteases of the RP-II type and variants of RP-II proteases exhibiting improved properties in comparison to the parent RP-II protease, DNA constructs and vectors coding for the expression of said proteases and variants, host cells capable of expressing the proteases and variants from the... Agent: Novozymes North America, Inc.

20070224674 - Selective enrichiment of microorganisms for desired metabolic properties: A method for selectively enriching for a microorganism able to metabolise a test substrate, and/or the enrichment of an enzyme involved in the metabolism of the test substrate, the method comprising the steps of: a) providing a population of microorganisms in a vessel, b) feeding fluid into the vessel at... Agent: Ladas & Parry

20070224675 - Expression cassette: An expression cassette comprises targeting sites flanking a Cre fusion gene and a Cre coding sequence interrupted by an intron. This cassette can be used for the generation CreAoxP constructs and to reduce toxicity caused by the over-expression of Cre in target cells.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070224676 - Expandable culture roller bottle: The present invention provides a roller bottle for cell growth culturing, the roller bottle including a bottom wall; a top wall having an opening formed therethrough; and, a side wall extending between the top and bottom walls, a plurality of corrugations being defined in the side wall. Further, a distance... Agent: David W. Highet Vp & ChiefIPCounsel Becton, Dickinson And Company

20070224677 - Method for creating perfusable microvessel systems: Microvessel networks are produced in vitro from tissue-engineered parent vessels sprouting into a supporting matrix, as for example gels, of extracellular matrix proteins. The microvessel systems are integrated into devices that allow for controlled perfusion with fluids. The vessels may include cells from one cell type, for example, endothelial cells,... Agent: George A Leone, Sr Citadel Patent Law

20070224678 - Functionalized artificial bone and joint compositions and methods of use and manufacture: The present invention provides a functionalized ceramic body for in vitro and in vivo use comprising a calcium aluminate containing phase that is functionalized with a linker group comprising at least one of an organic acid molecule, a phosphonic acid, an amine, and N,N-dicyclohexylcarbodiimide for providing a reactive location for... Agent: Craig G. Cochenour, Esq. Buchanan Ingersoll & Rooney PC

20070224679 - Lentiviral triplex dna, and vectors and recombinant cells containing lentiviral triplex dna: The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. These triplex structures can act as a cis-determinant of HIV-1 DNA nuclear import, allowing infection... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070224680 - Vehicle to transport a dna-modifying enzyme to a genome: A vehicle to transport a DNA-modifying enzyme towards a desired site in the genome, the DNA-modifying enzyme being coupled to a sequence recognizer that is specific for the desired site in the genome in such a way that the enzyme is able to perform its activity bound to the desired... Agent: Peacock Myers, P.C.

20070224681 - Collapsin response mediator protein-1 (crmp-1) transcriptional regulatory nucleic acid sequences: This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which demonstrates promoter and/or regulatory activities (such as providing a transcription factor binding site) to... Agent: Bingham Mccutchen LLP

20070224682 - High density growth of t7 expression strains with auto-induction option: Disclosed is a method for promoting auto-induction of transcription of cloned DNA in cultures of bacterial cells grown batchwise, the transcription being under the control of a promoter whose activity can be induced by an exogenous inducer whose ability to induce said promoter is dependent on the metabolic state of... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory

20070218451 - Peroxisome-proliferator activated receptor-alpha agonists for organ preservation: Methods and compositions for reducing, preventing or reversing organ damage and/or enhancing organ preservation by administration of a peroxisome-proliferator activated receptor-alpha (PPARα) agonist to the organ.... Agent: Leydig Voit & Mayer, Ltd

20070218473 - Method and apparatus for searching gene sequence: A method and apparatus for searching a gene sequence. The gene sequence search method includes receiving the gene sequence from a user, generating extended sequences including the received gene sequence, partial sequences included in the gene sequence and an inverse sequence complementary to the gene sequence, storing the gene sequence,... Agent: Cantor Colburn, LLP

20070218464 - Method for detecting a target nucleic acid sequence: A method of detecting a target nucleic acid sequence comprising providing a stem-and-loop structured nucleic acid for measurement wherein the nucleic acid comprises complementary sequence portions located at both terminals and a target sequence portion therebetween as well as a double-stranded portion formed by hybridization of the complementary sequence portions... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070218468 - Method for detecting the presence of water born pathogens and indicator microorganism: The present invention relates to a method for detecting the presence of water born pathogens and indicator microorganism including bacteria from water sample by selecting the target gene carried in template DNA by amplifying the target DNA using specific primers with biotinylated tag consist of all or a substantial part... Agent: Edwards Angell Palmer & Dodge LLP

20070218481 - Method for identifying drug-sensitizing antisense dna fragments and use thereof: The invention provides a method for generating and selecting drug-sensitizing antisense DNA fragments. In one embodiment, the method includes identifying a gene of interest using knowledge of bacterial physiology, biochemistry, genetics, genomics, and other means. The method includes PCR amplification of a gene of interest using genomic DNA as a... Agent: Dla Piper US LLP

20070218495 - Methods, libraries and computer program products for gene silencing with reduced off-target effects: The present invention provides methods, libraries and computer program products for selecting siRNA that reduce off-target effects and methods for gene silencing using these siRNAs. By comparing nucleotide sequences at positions 2-7 or 2-8 of the sense and/or antisense regions of candidate siRNAs to the 3′ UTR region of mRNAs,... Agent: Kalow & Springut LLP

20070218466 - Mxa as an antiviral drug and as a target for identification of antiviral drugs for dna virus infections: The invention features methods and compositions for use in a screening assay to identify agents having antiviral activity against a DNA virus by assessing the effect of a candidate agent upon alternative splicing of MxA, or by assessing the effect of a candidate agent on production of a variant form... Agent: Bozicevic, Field & Francis LLP

20070218465 - Therapeutic applications of aminolevulinate synthase: Systems and methods for increasing protoporphyrin IX accumulation in a target cell population using aminolevulinate synthase variants. Aminolevulinic acid-mediated photodynamic therapy is a promising approach to treating dysplasic disorders such as cancer and atherosclerosis, but is limited by the lack of a means to deliver optimal quantities of aminolevulinic acid... Agent: Smith Hopen, Pa

20070218456 - Cellular assays for signaling receptors: The present invention provides cells and methods related to signaling receptors. The cells of the invention express the signaling receptors (e.g., in a constitutively active state). The cells are useful for analyzing the signaling receptors and their related pathways. The invention further provides methods for studying interactions of the signaling... Agent: Invitrogen Corporation C/o Intellevate

20070218454 - Optical detection cell for micro-fluidics: The present invention relates to an optical detection cell for micro-fluidics. The detection cell provides a first layer, a detection cell layer contacting the first layer, a third layer contacting the detection cell layer and a detection channel defined through the detection cell to serve as a light path for... Agent: Agilent Technologies Inc.

20070218452 - Process for distributing drops of a liquid of interest onto a surface: The present invention relates especially to a process for the localized distribution of drops of a liquid of interest on an active surface. The process comprises the following steps an introduction of liquid of interest into a box containing the said active surface, and an extraction of liquid of interest... Agent: Mckenna Long & Aldridge LLP

20070218455 - Sample preparation of biological cells for analysis: A system for reliably and reproducibly exposing the contents of a biological cell to an analysis instrument comprising a sample handling unit that includes a first substrate with first substrate face and a second substrate with second substrate face. The first substrate face and the second substrate face are opposed.... Agent: Eddie E. Scott Assistant Laboratory Counsel

20070218453 - Sensing tool: This invention relates to a hollow-nanoparticle-based biosensing tool, which comprises proteins capable of forming nanoparticles through the incorporation of a lipid bilayer and specific biorecognition molecules bound thereto and a biosensing method using such tool.... Agent: Kubovcik & Kubovcik

20070218457 - Toxicity screening methods: The present invention provides methods of determining a level of toxicity of a given compound based on in vitro assays. The present invention provides particular methods of determining organ-specific toxicity and species-specific toxicity of a given compound based on in vitro assays. In addition, the present invention provides methods of... Agent: Dunlap, Codding & Rogers P.C.

20070218458 - Method for removal of viruses from blood by lectin affinity hemodialysis: The present invention relates to a method for using lectins that bind to pathogens having high mannose surface glycoproteins or fragments thereof which contain high mannose glycoproteins, to remove them from infected blood or plasma in an extracorporeal setting. Accordingly, the present invention provides a method for reducing viral load... Agent: Knobbe Martens Olson & Bear LLP

20070218472 - Association of pde4d allelic variants with stroke: The present invention provides methods for detecting a predisposition for stroke in individuals by correlating allelic variants of the phosphodiesterase 4D (PDE4D) gene and hypertension status. The invention further contemplates kits and computer program products for detecting PDE4D polymorphisms indicative of a predisposition for stroke correlated with an individual's hypertension... Agent: Townsend And Townsend And Crew, LLP

20070218485 - Biological bar code: The invention provides compositions and methods useful for identifying, verifying or authenticating any type of sample, whether the sample, is biological or non-biological.... Agent: Pillsbury Winthrop Shaw Pittman LLP

20070218494 - Branched polymer lables as drag-tags in free solution electrophoresis: End Labelled Free Solution Electrophoresis (ELFSE) provides a means of separating polymer molecules such as ssDNA according to their size, via free solution electrophoresis, thus eliminating the need for polymer separation via gels or polymer matrices. Here, end labels are provided that optimize branching architecture to increase hydrodynamic drag of... Agent: Kirby Eades Gale Baker

20070218477 - Circular probe amplification (cpa) using energy-transfer primers: The present invention provides methods and kits for the rapid exponential amplification of nucleic acid molecules using a padlock probe. The present invention improves upon the existing methods for amplifying padlock probes by eliminating or delaying the appearance of artifact products that cause false positive results, and also increase the... Agent: Philip S. Johnson Johnson & Johnson

20070218489 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent: Medlen & Carroll LLP

20070218480 - Detection and diagnosis of smoking related cancers: Gene probes for specific regions of chromosomes 1, 3, 9, 10 and 17 are now shown to be useful in the diagnosis and prognosis of smoking related cancers such as non-small cell lung cancer (NSCLC). For example, these probes can be used with fluorescence in situ hybridization (FISH), and used... Agent: Fulbright & Jaworski L.L.P.

20070218482 - Diagnostic assay for lung transplant: Methods and compositions for determining the suitability of a lung for transplantation are described.... Agent: Bereskin And Parr

20070218493 - Diagnostic marker for interferon responsiveness in multiple sclerosis: Disclosed is a method of determining interferon responsiveness in a patient suffering from multiple sclerosis. The method comprises determining an amount of a XAF-1 gene expression level in a blood sample, which is obtained from the patient undergoing interferon therapy. The amount of the XAF-1 gene expression level in the... Agent: Philip Swain, Phd C/o Gowling Lafleur Henderson

20070218459 - Diagnostic system for otolaryngologic pathogens and use thereof: The present invention relates to a method of detecting the presence of an otolaryngologic pathogen in a biological sample, and a sensor device, sensor chip, and nucleic acid probes useful for detecting otolaryngologic pathogens.... Agent: Nixon Peabody LLP - Patent Group

20070218475 - Efficient drug screening for protein targets: The methods of the invention allow extremely high throughput screening of chemicals against a large number of pharmacologically relevant targets. All of the pharmacologically relevant targets are expressed in cells, which are then screened against a fluorescently-tagged combinatorial library. Binding of the small molecules to the cells is then detected... Agent: Dla Piper US LLP

20070218484 - Feature quality in array fabrication: A method, and apparatus and computer program products for executing the method. The method includes obtaining a set of multiple images of a target feature location on an array of multiple features, each image of the set representing the target feature location following deposition of a corresponding sub-set of multiple... Agent: Agilent Technologies Inc.

20070218487 - Genetic markers for predicting disease and treatment outcome: The present invention provides for a method for identifying patients that are suitably treated by a therapy, such as a therapy involving administration of a fluoropyrimidine drug and/or a platinum drug. The method includes determining the expression level of at least one gene selected from a phospholipase 2 (PLA2) gene,... Agent: Foley & Lardner LLP

20070218476 - Identifying organisms by detecting intronic nucleic acid or encoded proteins: The present invention provides novel methods for characterizing organisms by identifying the presence, absence, size or sequence polymorphism of intronic regions. The method involves selecting intronic regions from nuclear or organellar gene sequences that are useful for differentiating between and among taxonomic groupings of organisms. Such intronic regions can be... Agent: Gordon & Rees LLP

20070218486 - Immunoassays, haptens, immunogens and antibodies for anti-hiv therapeutics: This invention provides compounds, methods, immunoassays, and kits relating to active, metabolically sensitive (“met-sensitive”) moieties of anti-HIV therapeutics, such as HIV protease inhibitors (PI), HIV nucleoside reverse transcriptase inhibitors (NRTI) and HIV entry inhibitors (EII).... Agent: Morgan, Lewis & Bockius LLP (sf)

20070218461 - Indole-diterpene biosynthesis: The present invention relates to the biosynthesis of indole diterpene compounds. In particular, the invention relates to genes encoding enzymes considered responsible for the synthesis of lolitrems.... Agent: Knobbe Martens Olson & Bear LLP

20070218471 - Method and device for detecting dna using surface-treated nanopore: Disclosed herein is a method for detecting DNA using a nanopore including treating the surface of a nanopore formed in a solid substrate with a substance carrying positive charges; introducing a DNA-containing sample into the surface-treated nanopore; and detecting electrical signals generated during translocation of the sample through the nanopore.... Agent: Cantor Colburn, LLP

20070218496 - Method for quick determination of cytokeratin 19 (ck19) and primers and probes therefore: A method for determination of CK19 mRNA is provided characterized in that a part of CK19 mRNA is amplified using a first primer hybridizing to a region located on a first exon of the CK19 gene and a second primer hybridizing to a region located on a second exon of... Agent: Roche Molecular Systems Inc Patent Law Department

20070218470 - Method for selective inactivation of viral replication: Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA compared to a host RNA under virus infection conditions; and determining whether any interaction of the agent with the component... Agent: Bozicevic, Field & Francis LLP

20070218460 - Method of estimating toxicity of drug: The present invention provides a novel in vitro prediction system of a phospholipidosis inducing potential of a novel drug-caused phospholipidosis marker gene and a drug. Specifically, the invention provides a reagent for prediction of a phospholipidosis inducing potential of a compound containing a nucleic acid capable of detecting the expression... Agent: Edwards Angell Palmer & Dodge LLP

20070218462 - Method of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hiperglycemic patients: A method of determining a potential of a diabetic patient to benefit from anti oxidant therapy for treatment of a vascular complication, the method comprising determining a haptoglobin phenotype of the diabetic patient and thereby determining the potential of the diabetic patient to benefit from said anti oxidant therapy, whereby... Agent: Pearl Cohen Zedek Latzer, LLP

20070218492 - Methods for detecting ovarian cancer and anticipating chemotherapy response: The disclosure relates to methods of detecting cancer and evaluating risk of cancer. The disclosure also relates to methods of predicting patient response to chemotherapy. The disclosure further relates to the use of a single nucleotide polymorphism in the human AFAP gene for the preparation of a diagnostic compounds for... Agent: Craig G. Cochenour, Esq. Buchanan Ingersoll & Rooney PC

20070218478 - Methods for fragmentation and analysis of nucleic acid: Methods for fragmenting and labeling DNA in a single reaction volume and incubation step using a uracil DNA glycosylase, an apurinic/apyrimidinic endonuclease, and a terminal transferase are disclosed. In a preferred embodiment the UDG, AP and TdT activities are first mixed together to form an enzyme mixture and then the... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070218467 - Methods for rapid identification and quantitation of nucleic acid variants: There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass... Agent: Medlen & Carroll LLP

20070218479 - Microrna precursors: Disclosed are methods of identifying microRNA motifs or microRNA precursors for a target gene or a set of target genes. Also disclosed are related computer-readable media... Agent: Fish & Richardson PC

20070218474 - Multiplex pcr assay: This invention relates to a multiplex PCR assay capable of screening or detecting the relevant microbial organism specific to Mycobacterium tuberculosis, Toxoplasma gondii, pathogenically important fungii and cytomegalo virus (CMV) in a sample, comprising a reaction mixture of a combination of 4 sets of primers, one of said primer for... Agent: Venable LLP

20070218469 - Novel mutations in hexosaminidase a: The present invention discloses methods and compositions for detecting novel mutations in the α chain of the hexosaminidase gene. These methods facilitate rapid screening for Tay-Sachs disease carriers, especially in the Ashkenazi Jewish population. The novel mutations include the single nucleotide substitutions 638A>C and 181C>T.... Agent: Nath & Associates, PLLC

20070218490 - Nucleic acid monomers with 2'-chemical moieties: The invention provides nucleic acid monomers with a 2′-modification that are useful for the incorporation of dyes or blocking groups. The monomers can be incorporated on the 3′-end of a dual labeled probe to inhibit PCR polymerase extension during PCR. The polymerase is inhibited from extending the probe at the... Agent: John Petravich Integrated Dna Technologies, Inc.

20070218491 - Oligomerization of amyloid proteins: The present invention provides methods and, accordingly, in vitro systems for generating stable and soluble oligomers of amyloid proteins, under physiological pH and temperature; and hence, a system for identifying and validating drugs that have the potential to prevent formation of soluble oligomers of amyloid proteins, to disaggregate soluble oligomers... Agent: Davidson, Davidson & Kappel, LLC

20070218463 - Rearranged squamous cell carcinoma antigen genes ii: The present invention relates to a SCCA1/SCCA2 fusion protein; plasmid containing the same; antibodies of said fusion protein; methods for detecting said protein; methods for diagnosing the presence or absence of SCC by determining the presence of SCCA1/SCCA2 fusion protein.... Agent: Samuels, Gauthier & Stevens LLP

20070218483 - Site-specific incorporation of fluorinated amino acids into proteins: This invention relates, in part, to newly identified polynucleotides, polypeptides, variants and derivatives thereof; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; and uses of the polynucleotides, polypeptides, variants and derivatives. The invention also relates to compositions of orthogonal aminoacyl-tRNA synthetases, and pairs of orthogonal... Agent: Mcnees Wallace & Nurick LLC

20070218501 - Assays to predict atherosclerosis and dysfunctional high-density lipoprotein: This invention provides novel assays for the detection of dysfunctional HDL. The assays are good diagnostics and/or prognostics for atherosclerosis or other pathologies characterized by an inflammatory response. In certain embodiments the methods involve measurements of heme-related HDL-associated proteins (e.g., haptoglobin, hemopexin, etc.), and/or measurements of the relative distribution of... Agent: Beyer Weaver LLP

20070218504 - Human leptin-derived polypeptides and uses thereof: A polypeptide that contains an amino acid sequence present in human leptin blocks the inhibitory effect of human C-Reactive Protein on human leptin. Accordingly, such a polypeptide is implicated in an approach to treating or preventing conditions associated with the impact of CRP on leptin.... Agent: Foley And Lardner LLP Suite 500

20070218505 - Identification of biomolecules through expression patterns in mass spectrometry: Systems, methods, apparatus, and computer programming useful in identifying proteins, peptides, carbohydrates, and other biomolecules, or for a validation of an identification of proteins, peptides, carbohydrates, and other biomolecules, is described. In particular, the invention provides systems, methods, apparatus, and programming useful for identifying proteins and other precursor biomolecules using... Agent: Torys LLP

20070218506 - Immunoassays for buprenorphine and norbuprenorphine: Methods, compositions and kits are disclosed directed at haptens, immunogens and immnoassays for buprenorphine (BUP) and nor buprenorphine (norBUP). The method comprises providing in combination in a medium (i) a sample suspected of containing buprenorphine (BUP) or norbuprenorphine (norBUP) and (ii) an antibody raised against an immunogen of buprenorphine (BUP)... Agent: Dade Behring Inc. Legal Department

20070218502 - Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation: The invention provides peptide synthons having protected functional groups for attachment of desired moieties (e.g. functional molecules or probes). Also provided are peptide conjugates prepared from such synthons, and synthon and conjugate preparation methods including procedures for identifying optimum probe attachment sites. Biosensors are provided having functional molecules that can... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20070218500 - Method and apparatus for detection of live bacterium within test subject through specifically labeling thereof: A method and apparatus for detection whereby live bacteria among microbes as an antigen can be detected rapidly in a short period of time through specifically labeling of live bacteria within a test subject antigen and whereby testing assurance can be ensured. The method and apparatus are characterized in that... Agent: Sughrue Mion, PLLC

20070218503 - Methods of polypeptide identification, and compositions therefor: Methods are disclosed for identifying one or more proteins or polypeptides comprised by a sample. The methods comprise determining binding of each polypeptide with respect to each binding pool of a plurality of binding pools, wherein each binding pool comprises one or more probes which bind a structure comprised by... Agent: Washington University C/o Sonnenschein Nath & Rosenthal L.l.p

20070218499 - Monoclonal antibodies that target pathological assemblies of amyloid b (abeta): Disclosed herein are antibodies that bind with high specificity to soluble oligomers of amyloid β (Abeta) and methods of employing those antibodies. The antibodies are able to distinguish between Alzheimer's Disease (AD) and control human brain extracts. The antibodies identify endogenous Abeta oligomers in AD brain slices and also bind... Agent: Licata & Tyrrell P.C.

20070218497 - Quick test for the diagnosis of alzheimer's disease: The invention relates to method for the diagnosis of Alzheimer's disease or the early stages thereof or a predisposition to said disease. Said method is based on quantitative determination of a mitogenically expressible surface marker, in particular CD69, and peripherally accessible cells, e.g. skin cells or lymphocytes, (a) prior to... Agent: Intellectual Property / Technology Law

20070218498 - Use of soluble flt-1 and its fragments in cardiovascular conditions: The present invention relates to materials and procedures for evaluating patients suffering from cardiovascular conditions, particularly acute coronary syndromes. In particular, an assay configured to measure the level of soluble FLT-1 in a patient sample, alone or in combination with one or more other markers, provides diagnostic and/or prognostic information.... Agent: Richard J. Warburg Foley & Lardner LLP

20070218508 - Detection and amplification of ligands: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an... Agent: Hahn Loeser & Parks, LLP

20070218507 - Inhibitor of apoptosis proteins and nucleic acids and methods for making and using them: The invention provides polypeptides comprising inhibitor of apoptosis protein (IAP) family members, such as BmIAP initially derived from Bombyx mori BmN cells, and nucleic acids encoding them, and methods for making and using these compositions, including their use for inhibiting apoptosis.... Agent: Needle & Rosenberg, P.C.

20070218509 - Murine living tissue model & usestthereof: The invention provides an in vitro method for observing an effect of a test agent on a murine tumour model. The model consists a three-dimensional array of murine fibroblasts in a collagen gel which mimics a connective tissue substrate, on or in which are grown benign or malignant murine tumour... Agent: Morgan Lewis & Bockius LLP

20070218511 - Methods for the diagnosis and treatment of lung cancer: The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell, and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition.... Agent: Foley & Lardner LLP

20070218512 - Methods related to mmp26 status as a diagnostic and prognostic tool in cancer management: Disclosed herein are compositions and methods involving identifying MMP-26 in a subject with cancer.... Agent: Needle & Rosenberg, P.C.

20070218510 - Use of protein psa3 as a marker for colorectal cancer: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein proteasome subunit alpha 3 (PSA3) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring PSA3 in said... Agent: Roche Diagnostics Operations Inc.

20070218514 - Diagnostic methods relating to graves' disease and other autoimmune disorders: The invention provides methods of diagnosing Graves' disease (GD), Rheumatoid Arthritis (RA) and other autoimmune diseases in an individual by detecting a disproportionately large fraction of peripheral blood T cells express IGF-1R (CD3+ IGF-R+) compared to normal control samples. In a further embodiment, the invention provides methods of diagnosing, prognosing,... Agent: Mcdermott, Will & Emery

20070218513 - Differentially expressed genes related to coronary artery disease: The present invention relates to genes whose expression is correlated to the prevalence of coronary artery disease. In particular, the invention relates to methods of prognosis, diagnosis and methods of monitoring coronary artery disease based on the measurement of gene expression. In addition, the present invention relates to methods of... Agent: Novartis Corporate Intellectual Property

20070218515 - Method and kits for the determination of the antigens on the red blood cells and antibodies of serum: The Present invention relates to biological test methods using micro trays for determining red blood cell antigens and corresponding antibodies of the serum or plasma from individuals using cell aggregation analysis method. This invention also relates to kits for determining red blood cell typing, wherein the kits including mixture monoclonal... Agent: Nina Zhou

20070218517 - Methods for comparing the immunogenicity of products and uses thereof: The present invention relates to methods of determining the immunogenic potential of a test product by comparing the immunogenic profile or fingerprint of the test product to the immunogenic profile or fingerprint of a reference product.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070218516 - Recombinant chimeric human anti-botulinum antibodies: In this application is described the production of recombinant, chimeric, humanized antibodies specific for both BoNt/A and BoNT/B. The humanized antibodies were converted from a mouse anti-BoNT/A/B Fab fragment into a whole human IgG1 antibody. The antibodies are useful in assays for detecting human exposure to BoNT/A and BoNT/B.... Agent: U.s. Army Medical Research And Materiel Command Attn: Mcmr-ja (ms. Elizabeth Arwine- Patent Atty)

20070218518 - Host receptor for pathogenic bacteria: A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events... Agent: Woodcock Washburn LLP

20070218519 - Diabetes-associated markers and methods of use thereof: Disclosed are methods of identifying subjects with Diabetes or a pre-diabetic condition, methods of identifying subjects at risk for developing Diabetes or a pre-diabetic condition, methods of differentially diagnosing diseases associated with Diabetes or a pre-diabetic condition from other diseases or within sub-classifications of Diabetes, methods of evaluating the risk... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20070218520 - Method for measuring binding of a test compound to a g-protein coupled receptor: The invention provides a method for measuring binding of a test compound to a G-Protein Coupled Receptor (GPCR). The invention also provides a method for identifying and measuring the effect that an agent has upon modulating the binding of a test compound to a G-Protein Coupled Receptor.... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070218521 - Medium for identification of micro-organisms: Disclosed is a medium for the detection and/or identification of a Candida yeast, the medium comprising: a chromogen; carbohydrate in the range 1-5 gms/litre; and an alcohol; the medium being such that growth of the Candida yeast under appropriate conditions results in hydrolysis of the chromogen to generate a chromophore... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070218522 - Methods and compositions for rapidly detecting and quantifying viable legionella: Methods and compositions detect and quantify viable Legionella and other heterotrophic aerobic bacteria. Dip-slides that include an absorbent medium, growth promoting, and growth selective substances are useful in rapid detection and quantification of microcolonies of Legionella. Most probable number method of detection and quantification of Legionella are disclosed.... Agent: Barnes & Thornburg LLP

20070218526 - Method for zymotic production of fine chemicals containing sulphur (meta): The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (meta) gene.... Agent: Connolly Bove Lodge & Hutz, LLP

20070218523 - Modified human thymic stromal lymphopoietin: Modified, furin resistant human TSLP polypeptides and polynucleotides encoding the modified human TSLP polypeptides are provided. Pharmaceutical compositions, B and T cell activation agents, assays and methods of use are also described.... Agent: Immunex Corporation Law Department

20070218524 - Polypeptide having rnase iii activity: A polypeptide having an RNase III activity with which the length of a dsRNA degradation product can be easily controlled depending on reaction conditions and, in preparing a dsRNA having a length allowing it to serve as an siRNA in RNA interference, a low-molecular weight product having little RNA interferring... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070218525 - Process for producing dipeptides: The present invention provides a process for producing a dipeptide other than D-alanyl-D-alanine and D-alanyl-D-serine using, as an enzyme source, a culture of a microorganism having the ability to produce a protein having D-alanine-D-alanine ligase activity or a treated matter of the culture, and a process for producing a dipeptide... Agent: Nixon & Vanderhye, PC

20070218527 - Tryptophanyl-trna synthetase-derived polypeptides useful for the regulation of angiogenesis: The invention provides an isolated nucleic acid encoding a water-soluble polypeptide fragment of human tryptophanyl-tRNA synthetase, which is useful for the inhibition of angiogenesis. The nucleic acid comprises a polynucleotide of SEQ ID NO: 6, a polynucleotide hybridizable to SEQ ID NO: 6, a polynucleotide that encodes the polypeptide of... Agent: Olson & Hierl, Ltd.

20070218528 - Methods and compositions for targeted cleavage and recombination: Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered... Agent: Robins & Pasternak

20070218530 - Methods for enzymatic hydrolysis of lignocellulose: Compositions and methods for biomass conversion are provided. Compositions comprise novel enzyme mixtures that can be used directly on lignocellulose substrate. Methods involve converting lignocellulosic biomass to free sugars and small oligosaccharides with enzymes that break down lignocellulose. Novel combinations of enzymes are provided that provide a synergistic release of... Agent: Alston & Bird LLP

20070218529 - Non-reducing saccharide-forming enzyme, trehalose-releasing enzyme, and process for producing saccharides using the enzymes: A non-reducing saccharide-forming enzyme and a trehalose-releasing enzyme, which have an optimum temperature in a medium temperature range, i.e., a temperature of over 40 or 45° C. but below 60° C.; and an optimum pH in an acid pH range, i.e., a pH of less than 7. The two-types of... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070218531 - Micro-organism and a method of producing paclitaxel by the use of the same: There is provided a new strain, i.e. the alternaria alternata var. monosporus ST-026R CGMCC No. 0899, and its use in the production of paclitaxel. The invention also provides a method for the production of paclitaxel by using the strain CGMCC No. 0899.... Agent: Birch Stewart Kolasch & Birch

20070218532 - Novel escherichia coli having accession no. pta 1579 and its use to produce polyhydroxybutyrate: The present invention provides a novel genetically modified Escherichia coil JM109 bearing accession number PTA 1579, containing the gene coding for poly-beta-hydroxybutyrate synthesis and a method of using this bacterium to produce poly-beta-hydroxybutyrate to the extent of 60% or more of the cell weight.... Agent: Baker Botts L.L.P.

20070218533 - Enhanced alcohol tolerant microorganism and methods of use thereof: Embodiments of the present invention provide methods and compositions for microorganisms having increased alcohol tolerance. In certain embodiments, methods for using such microorganisms, and methods for identifying gene or genetic regions responsible for increased alcohol tolerance are contemplated.... Agent: Faegre & Benson LLP Patent Docketing

20070218534 - Measurement and use of molecular interactions: The present invention is based on the realization that the bonds between a target molecule, or a target molecule attached to a particle, and a surface, can be ruptured by mechanically oscillating the surface at increasing amplitude, leading to detachment of the target molecule or particle from the surface. The... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070218535 - Methods for production of recombinant alpha1-antitrypsin: Methods of producing properly folded recombinant α1-antitrypsin (AAT) polypeptide are provided. Denatured recombinant AAT polypeptide is refolded by first solubilizing the polypeptide with a chaotroph at high pH, followed by refolding in the presence of reduced concentrations of chaotroph and in the presence of PEG, glycerol or sucrose, or a... Agent: Morrison & Foerster LLP

20070218536 - Polyvalent viral vectors and a system for production thereof: A system for generating viral vectors carrying two distinct expression cassettes is provided. The system utilizes a unique polyvalent transfer vector that permits efficient detection and selection of inserted expression cassettes.... Agent: Howson And Howson

20070218537 - Method for treating ammonia-containing wastewater: A process for treating ammonia containing wastewater includes bringing an ammonia-treating material and ammonia containing wastewater into contact with each other to remove ammonia in the wastewater continuously as nitrogen gas, the ammonia-treating material including a long carrier and complex bacterial sludge attached and immobilized on the biomass carrier, the... Agent: The Webb Law Firm, P.C.

20070218538 - Polypeptides and bacterial strains for increased protein production: The invention provides polypeptides, nucleic acid sequences, bacterial strains, methods and kits for producing exogenous protein. More specifically, the invention provides RNase E polypeptides that posses impaired mRNA degrading activity and efficient rRNA and tRNA processing activity. These polypeptides may be utilized for producing exogenous protein.... Agent: Polsinelli Shalton Welte Suelthaus PC

20070218540 - Bioelectrolytic methanogenic/methanotrophic coupling for bioremediation of ground water: The invention disclosure is a method of bioremediation of wastewater, particularly groundwater, by utilizing coupled anaerobic and aerobic biological treatment, more specifically, methanogenic (strictly anaerobic) and methanotrophic (strictly aerobic) microbial populations, in combination with a supply of in-situ generated water-dissolved oxygen and hydrogen. Water electrolysis is used to produce water-dissolved... Agent: National Research Council Of Canada 1200 Montreal Road

20070218539 - Method for the degradation of mtbe and tba: A method for the degradation of methyl-tertiary-butyl-ether (MTBE) and tertiary-butanol (TBA) using a mixture of Pseudomonas putida is described. The method enables almost complete remediation of MTBE and TBA in situ in contaminated water and/or soil.... Agent: Ian C. Mcleod Mcleod & Moyne, P.C.

20070218541 - Fermenter and fermentation method: A method is described for treating a biomaterial waste stream to remove pollutants and to generate a product. The method comprises the steps of injecting the