Chemistry: molecular biology and microbiology inventions 09/07

20070224603 - Cleavable linkers for polynucleotides: In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.... Agent: Agilent Technologies Inc.

20070224597 - Isolating fetal trophoblasts: Methods for isolating and purifying fetal trophoblasts from a mucus sample obtained from the uterine cavity of a pregnant female. The mucus sample is transported from a clinical collection facility to a laboratory in a transportation medium so the cells remain viable. The mucus sample is then subjected to precise... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070224616 - Method for forming molecular sequences on surfaces: A method for forming molecular sequences includes derivatizing an unconfined substrate surface with at least one linker containing a protected reactive group. The substrate is contacted with a solution containing a photogenerated reagent precursor and a buffer and/or a neutralizer. A photogenerated reagent is generated in at least a portion... Agent: Julia Church Dierker Dierker & Associates, P.C.

20070224602 - Thiocarbonate linkers for polynucleotides: In various embodiments of the invention, novel compositions having a polynucleotide bound to a substrate via a cleavable linker are provided, and methods of cleaving a polynucleotide from a substrate are provided.... Agent: Agilent Technologies Inc.

20070224646 - Method for estimating protein-protein binding affinities:

20070224652 - Blood group antigens of different types for diagnostic and therapeutic applications: The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing.... Agent: Ivor Elrifi, Esq. Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20070224657 - Distribution of pon1 as a marker of lipid related disorders: A method of diagnosing a subject with a lipid related disorder is disclosed, the method comprising determining an amount or activity of PON1 or apo-A1 in an LPDS fraction of a serum of the subject, wherein an amount or activity of PON1 above a predetermined threshold is indicative of the... Agent: Martin D. Moynihan Prtsi, Inc.

20070224587 - Allograft packaging system: An allograft method and apparatus for providing and allograft package package comprised of a sponge having an internal cavity for containing an allograft and a sealable container for enclosing the sponge and maintaining the environment established at the time of closure of the sealed container.... Agent: Bruce & Mccoy

20070224589 - Protection of biologically active molecules using amphiphiles: A process for the protection of a biologically active compound against the effect of for instance enzymes, chemicals, oxygen, radicals or sunlight. The process is characterized in comprising the step of bringing the biologically active compound in contact with at least one SAINT-molecule. Thereby a good protection from the biologically... Agent: Peacock Myers, P.C.

20070224588 - Trophoblast preservation/pretreatment medium and method: An aqueous preservation medium for the selective preservation of trophoblasts obtained in a sample of cervical mucus which permits transportation of such sample to a laboratory facility for analysis and selectively preserves fetal trophoblasts in said sample while presenting conditions that are antagonistic to many maternal cells.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070224591 - Rotation-based microsampler, system and method of using the same: A microsampler disc for use in the analysis of agents is described as including a plurality of microstructures configured and spaced to promote movement of a fluidic medium containing agents radially outwardly and promote filtering of one species of agents from other species of agents. An analysis system using the... Agent: General Electric Company Global Research

20070224590 - Single cell planar chromatography: A system for preparing a biological cell for analysis comprising the deposition of the biological cell on a planar chromatographic support medium and lysis of the biological cell. In one embodiment, the present invention includes one or two dimensional chromatography of the biological cell. One embodiment of the present invention... Agent: Eddie E. Scott Assistant Laboratory Counsel

20070224594 - Detection of influenza virus: The present application describes methods for detecting influenza A and/or influenza B and/or distinguishing between pathogenic and seasonal influenza A subtypes. Many of these preferred formats employ pan-specific antibodies (i.e., that react with all or at least multiple strains within an influenza type) to detect presence of influenza A and/or... Agent: Townsend And Townsend And Crew, LLP

20070224593 - Diagnosis of transmissible spongiform encephalopathy: The invention features a method of diagnosing or providing a prognosis regarding the state of Transmissible Spongiform Encephalopathies (TSEs) in a mammal by contacting a target tissue or other environmental sample with a detectable compound, which binds to a non-amyloid form of a disease specific prion (PrP-d). An increase in... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070224619 - Apolipoprotein e genotyping and accompanying internet-based health management system: The invention provides a system for monitoring a patient that includes: 1) a blood test that measures an Apo E genotype or a derivative thereof from the patient to generate Apo B information; 2) a database that receives and stores the patient's Apo E information; and 3) an Internet-based system... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070224620 - Compositions and methods for capturing and analyzing cross-linked biomolecules: Methods, compositions and kits to capture cross-linked protein complexes to a support matrix in a stable, covalent bridge of attachment are provided.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20070224596 - Compositions and methods for the modifying hypoxia induced gene regulation: This invention provides compositions and methods to identify candidate agents capable of altering the biological activity of a polypeptide encoded by a polynucleotide involved in hypoxia-related tumorigenesis. In one aspect, the biological activity is the induction of hypoxia-related gene enolase 2 or a biological equivalent thereof. In another aspect, the... Agent: Genzyme Corporation Legal Department

20070224630 - Compositions and methods of selective nucleic acid isolation: The invention relates to methods for isolating and/or identifying nucleic acids. The invention also provides kits for isolating and/or identifying nucleic acids.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070224614 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent: Medlen & Carroll LLP

20070224612 - Compounds and methods for nucleic acid mismatch detection: In accordance with the present invention there are provided sterically demanding intercalators. These compounds are useful for detection of a base-pair mismatch, such as by measuring fluorescence of complexes formed by the compounds of the invention and nucleic acid duplexes. The compounds are also capable of catalyzing photolytic cleavage of... Agent: Dla Piper US LLP

20070224626 - Comprehensive dna methylation profiling in a human cancer genome identifies novel epigenetic targets: The present invention provides DNA marker sequences that are differentially methylated in samples from normal individuals and individuals with brain cancer. The invention further provides methods of identifying differentially methylated DNA marker sequences and their use the detection and diagnosis of gliomas.... Agent: Townsend And Townsend And Crew, LLP

20070224631 - Device and method for high-throughput quantification of mrna from whole blood: Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to oligo(dT)-immobilized multi-well plates.... Agent: Knobbe Martens Olson & Bear LLP

20070224632 - Device and method for high-throughput quantification of mrna from whole blood: Disclosed are a method, device kit, and automated system for simple, reproducible, and high-throughput quantification of mRNA from whole blood. More particularly, the method, device, kit and automated system involve combinations of leukocyte filters attached to oligo(dT)-immobilized multi-well plates.... Agent: Knobbe Martens Olson & Bear LLP

20070224627 - Facilitation of translocation of molecules through the gastrointestinal tract: The invention concerns methods and means for facilitating the translocation of molecules through the gastrointestinal tract of mammals. In particular, the invention concerns methods for identifying antibodies, including antibody fragments, capable of translocation from the lumenal side of gastrointestinal tissue into the blood stream or into the lymphatic circulation. The... Agent: Heller Ehrman LLP

20070224609 - Genotoxic testing: The present invention relates to methods for detecting for the presence of an agent that putatively causes or potentiates DNA damage comprising subjecting a cell (containing a DNA sequence encoding a reporter protein operatively linked to a human GADD45α gene promoter and a human GADD45α gene regulatory element arranged to... Agent: Gates & Cooper LLP Howard Hughes Center

20070224611 - Inactivation method: The present invention relates to the field of thermostable enzymes, methods for their inactivation, and related uses, kits and reagents. In particular, the invention relates to a method for reversible inactivation of thermophilic enzymes by chemical modification under aqueous or non-aqueous conditions.... Agent: Buchanan, Ingersoll & Rooney PC

20070224599 - Interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: People with the SS variant of the human serotonin transporter gene are more susceptible to episodes of major depression when faced with mildly threatening life events than people with the SL or LL variants. Methods for identifying and treating such patients are provided.... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070224629 - Laser exposure of photosensitive masks for dna microarray fabrication: A method and apparatus for forming a polymer array on a substrate suitable for synthesizing polymer sequences. This includes forming an array, each location of the array having at least one strand end, forming photosensitive protection on the strand ends, and selectively scanning and modulating at least one energy beam... Agent: Intel/blakely

20070224613 - Massively multiplexed sequencing: The present invention provides multiplexed methods for analyzing polynucleotides associated with sample tags. The multiplexed information is deconvoluted by single-molecule and more generally single-particle detection methods. In particular, a method for determining nucleic acid sequence information is provided.... Agent: Michael Strathmann

20070224617 - Mechanically induced trapping of molecular interactions: The invention provides devices and methods for surface patterning the substrate of a microfluidic device, and for detection and analysis of interactions between molecules by mechanically trapping a molecular complex while substantially expelling solvent and unbound solute molecules. Examples of molecular complexes include protein-protein complexes and protein-nucleic acid complexes.... Agent: Townsend And Townsend And Crew, LLP

20070224618 - Method for determining protein solubility: The present invention relates to methods of screening for expression of a soluble candidate protein within an expression library of candidate proteins. The method involves fusing each candidate protein in the library to a peptide substrate and identifying cells that express soluble candidate protein by detecting enzymatic modification of the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070224605 - Method for preparing a dna chip and use thereof: The present invention relates to a method for producing a DNA chip, which comprises the steps of: (a) cloning a probe, where a linker is coupled to one or both ends of an oligonucleotide to be integrated on a slide, into a vector; (b) transforming host cells with the vector;... Agent: Intellectual Property / Technology Law

20070224604 - Method of determining the presence and/or concentration of substances of interest in fluids: Magnetic particles coated with specific antibodies for substances of interest are introduced into a fluid sample. Over time and with agitation, the magnetic particles become attached to the substance of interest within the fluid. The fluid is then introduced to a magnetic field gradient provided between two magnets (1, 5).... Agent: Kaplan Gilman Gibson & Dernier L.L.P.

20070224610 - Method of quantifying hiv-1 rna-dna hydrid and diagnosis kit: A diagnostic kit for evaluating the progress of an HIV-1-related disease and/or the efficacy of an anti-HIV-1 treatment using the quantity of an HIV-1 RNA-DNA hybrid in a sample as an indicator, comprising: at least one primer pair consisting of a downstream primer having a sequence complementary to a portion... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070224615 - Methods for assaying protein-protein interactions: The invention relates, in part, to methods for detecting, monitoring, measuring or assessing an interaction between at least two proteins. The invention also relates, in part, to methods for determining if a test compound, or a mix of compounds, modulates an interaction between at least two proteins. In some embodiments,... Agent: Invitrogen Corporation C/o Intellevate

20070224600 - Methods for diagnosing and treating kidney and colorectal cancer: Methods, reagents and kits for diagnosing and treating cancer such as kidney or colorectal cancer are disclosed. An immunoassay for detecting kidney or colorectal cancer is based on the relative change of the ADAMTSL4 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney or... Agent: Perkins Coie LLP

20070224607 - Methods for identifying compounds of interest using encoded libraries: The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.... Agent: Lahive & Cockfield, LLP

20070224606 - Mn/ca ix/ca9 and renal cancer prognosis: Herein disclosed are methods that are prognostic for renal cell carcinoma, particularly renal clear cell carcinoma, afflicting a vertebrate. An exemplary prognostic method comprises detecting the presence of, and quantitating the level and/or extent of a MN/CA9 gene expression product in a sample from the affected subject, wherein if 50%... Agent: Leona L Lauder Law Offices Of Leona L Lauder

20070224624 - Nucleic acid encoding spinocerebellar ataxia-2 and products related thereto: The present invention provides isolated nucleic acids encoding human SCA2 protein, or fragments thereof, and isolated SCA2 proteins encoded thereby. Further provided are vectors containing invention nucleic acids, probes that hybridize thereto, host cells transformed therewith, antisense oligonucleotides thereto and compositions containing antibodies that specifically bind to invention polypeptides, as... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070224595 - Nucleic acid molecules and other molecules associated with plants: Expressed Sequence Tags (ESTs) isolated from wheat are disclosed. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The disclosed ESTs have utility in the development of new strategies for understanding critical plant developmental and metabolic pathways. The disclosed... Agent: Lawrence M. Lavin, Jr. Monsanto Company

20070224622 - Plant chimeric binding polypeptides for universal molecular recognition: Libraries of nucleic acids encoding chimeric binding polypeptides based on plant scaffold polypeptide sequences. Also described are methods for generating the libraries.... Agent: Fish & Richardson PC

20070224628 - Protein isoform discrimination and quantitative measurements thereof: The invention relates to methods, reagents and apparatus for detecting protein isoforms (e.g., those due to alternative splicing, or different disease protein isoforms or degradation products) in a sample, including using combinations of capture agents to identify the isoforms to be detected/measured.... Agent: Goodwin Procter LLP Patent Administrator

20070224601 - Quantification of depurination through the use of two cleavage sites: The invention is directed an array comprising at least one depurination probe including a depurination sensitive first cleavage site adjacent a first tag region; and a base-cleavable second cleavage site adjacent a second tag region wherein the first tag region and the second tag region are independently quantifiable upon release... Agent: Agilent Technologies Inc.

20070224608 - Recombinant 12-kda protein useful for the detection of respiratory allergies: The present invention discloses the detection of an important 12K-Da protein having cross-reactivity amongst different prevalent allergenic grasses and fungi can be useful for detection of respiratory allergies. Conventionally, the whole extracts that are used for diagnosis are unable to specifically detect the causative agents. In addition, they are also... Agent: Birch Stewart Kolasch & Birch

20070224621 - Sequential reporter enzyme luminescence (srl) methods and compositions for practicing the same: Sequential reporter enzyme luminescence (SRL) methods are provided. In the subject methods, the activity of a reporter enzyme is evaluated using a secondary reporter system that employs a product of a reporter enzyme mediated reaction as a luminescent substrate, e.g., luciferase substrate. Also provided are kits and other compositions that... Agent: Bozicevic, Field & Francis LLP

20070224623 - Simplified qtl mapping approach for screening and mapping novel markers associated with beef marbling: Particular aspects provide an inexpensive QTL mapping approach for genome-wide scans of QTL linked markers and for narrowed locations of QTL regions, which may comprise integration of the amplified fragment length polymorphism (AFLP) with DNA pooling and selective genotyping and comparative bioinformatics tools. AFLP simultaneously screens high numbers of loci... Agent: Frommer Lawrence & Haug

20070224625 - Site-specific enzymatic deposition of metal in situ: The present invention provides compositions, kits, assembles of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In particular, the invention relates to use of enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also... Agent: Wilson Sonsini Goodrich & Rosati

20070224598 - System and method for detection of mutations in jak2 polynucleotides: Disclosed are a system and methods for identifying JAK2-specific polynucleotide sequences in a biological sample. Also disclosed are oligonucleotide primer and probe comopositions for detecting mutations in a JAK2 polynucleotides, and the JAK2V617F mutation in specific, as well as systems, diagnostic kits and articles of manufacture comprising JAK2-specific primer and... Agent: Haynes And Boone, LLP

20070224642 - Analytical method for protein mapping using hydrogen/deuterium exchange: Analytical methods using hydrogen/deuterium exchange are provided which reduce or eliminate the back-exchange of deuterium for hydrogen. The methods, which are useful in protein and peptide mapping, include the steps of (a) providing a peptide or protein comprising a solvent accessible hydrogen; (b) exchanging the solvent accessible hydrogen for a... Agent: Sutherland Asbill & Brennan LLP

20070224641 - Apparatus and method for ziegler-natta research: A combinatorial method for identifying a catalyst composition for use in the heterogeneous Ziegler-Natta addition polymerization of an olefin monomer, said catalyst composition comprising a compound of a metal of Group 2 of the Periodic Table of the Elements.... Agent: The Dow Chemical Company

20070224640 - Device and method for protein analysis: A device for protein analysis or mapping, includes an array of particulate nanoparticles, wherein said nanoparticles are bound, preferably co-immobilized, at specific spots on a planar read-out surface or substrate and are provided with a plurality of capture probes for capturing proteins, preferably glycoproteins. A method in which the device... Agent: Young & Thompson

20070224643 - Methods and compositions for the diagnosis of diseases of the aorta: The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to the use of biomarkers, either individually or in combinations with one another to rule in or out diseases of the aorta and its branches,... Agent: Foley & Lardner LLP

20070224634 - Methods for detecting l-ficolin dependent activation of the lectin pathway of complement and kits therefor: The invention provides methods, assays and kits for detecting L-ficolin dependent activation of the lectin pathway of complement and for identifying L-ficolin abnormalities. Also provided are methods for detection of gram positive bacteria based on the interaction between L-ficolin complexes and LTA.... Agent: Morrison & Foerster LLP

20070224633 - Muteins of tear lipocalin: The present invention relates to novel muteins derived from tear lipocalin or a homologue thereof. In particular, the invention relates to a mutein of human tear lipocalin. The invention also refers to a corresponding nucleic acid molecule encoding such a mutein and to a method for its generation. The invention... Agent: Foley And Lardner LLP Suite 500

20070224645 - Novel cell-based phosphodiesterase assays: The present invention relates to improved cell-based assays for the in vivo assessment of phosphodiesterase (PDE) activity using cyclic nucleotide-gated channels as cyclic nucleotide sensors, and for the assessment of the effect of PDE modulating compounds.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070224644 - Ocular fluid markers: The present invention relates to the analysis and monitoring of ocular fluids for determining the physiological state of an organism, to monitor drug efficacy and dynamics, for early disease detection, as well as to certain molecular markers and fingerprints of identified molecules or molecule fragments in such analysis.... Agent: Millen, White, Zelano & Branigan, P.C.

20070224637 - Oxidative protection of lipid layer biosensors: The present invention provides methods and composition related to lipid layers with increased stability to oxidative degradation. In one embodiment, the invention provides lipid layers comprising antioxidant inclusion molecules that permit biosensors with increased performance and functional lifetime due to increased oxidative protection. In addition to these lipid-layer compositions, the... Agent: Howrey LLP

20070224636 - Pyrrolo[1,2b]pyridazine compounds and their uses: e

20070224635 - Regulated stop codon readthrough: Methods for screening or selecting cells expressing a polypeptide of interest, e.g. for selecting cells expressing a desired level of a polypeptidé of interest, for evaluating recombinant polypeptide expression in a population of cells, or for selecting cells expressing a polypeptide with a desired binding affinity to a ligand, as... Agent: Maxygen, Inc. Intellectual Property Department

20070224638 - Secreted proteins as early markers and drug targets for autoimmunity, tumorigenesis and infections: The present invention relates to a method for the early diagnosis of a disease having a pre-inflammatory phase, or for the diagnosis of a predisposition to said disease, in a mammal, prior to any clinical signs, comprising measuring the level of at least a marker protein chosen amongst the following... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070224639 - Substrate for immobilizing biomolecules, biochip, and biosensor: A substrate for immobilizing biomolecules comprises a chip substrate, a hydrophilic monolayer, and a lipid bilayer, and a biochip comprising the substrate for immobilizing biomolecules on which biomolecules are immobilized. The substrate for immobilizing biomolecules includes a transparent chip substrate, a metal layer provided on the chip substrate, a monolayer... Agent: Osha Liang L.L.P.

20070224648 - Methods and compositions for the diagnosis of treatment of type 2 diabetes: Methods and compositions for the modulation of insulin secretion.... Agent: Marshall, Gerstein & Borun LLP

20070224647 - Monitor protein for measuring processing of protein: A monitor protein for measuring processing of a protein comprising a processing region which contains an amino acid residue or an amino acid residue sequence to be processed and a secretory chimeric protein which originates in the stereostructure of a protein containing at least a processing region formed by the... Agent: Knobbe Martens Olson & Bear LLP

20070224651 - Reduction of platelet interference in plasma assay samples: The present invention relates to compositions for improving assay accuracy for plasma samples by decreasing or eliminating false results due to platelet interference. The compositions of the present invention comprise compositions that include a platelet interference reducing agent in an amount effective to decrease the platelet interference activity in the... Agent: Woodcock Washburn LLP

20070224650 - Systems and methods for screening for modulators of neural differentiation: The present invention provides in vitro systems for use in identifying modulators of neural differentiation. Also provided are modulators identified by these systems. The present invention further provides methods for identifying a modulator of neural differentiation, a modulator of an FGF signalling pathway, a modulator of FGF-dependent neural differentiation, a... Agent: Baker Botts L.L.P.

20070224653 - Methods for modulating an immune response by modulating krc activity: This invention demonstrates that KRC molecules have multiple important functions as modulating agents in regulating a wide variety of cellular processes including: inhibiting NFkB transactivation, increasing TNF-alpha induced apoptosis, inhibiting JNK activation, inhibiting endogenous TNF-alpha expression, promoting immune cell proliferation and immune cell activation (e.g., in Th1 cells and/or Th2),... Agent: Lahive & Cockfield, LLP

20070224649 - Novel scavenger receptor: Novel scavenger receptors having an SR structure and a collectin-like structure are provided, which can be utilized in the elucidation of mechanisms of macrophage and basic immunity; in the elucidation of mechanisms of the development of a wide variety of diseases such as arteriosclerosis, diabetic complications and Alzheimer's disease, hyper... Agent: Marshall, Gerstein & Borun LLP

20070224654 - Method of detecting an antibody in a liquid sample: v

20070224655 - Methyltransferase assays: The present invention relates to coupled enzyme assays. In particular, the present invention provides a coupled fluorescent assay for detection of S-adenosylmethionine (AdoMet)-dependent methyltransferase activity.... Agent: Medlen & Carroll, LLP

20070224656 - Modulation of abeta levels by beta-secretase bace2: The present invention is based on the findings that BACE2, a homolog of β-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of Aβ. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique... Agent: Morrison & Foerster LLP

20070224658 - Cell growth: The present invention relates to use of peptide containing and peptide free synthetic low density lipoprotein (sLDL) particles as cell growth supplements for the growth of eukaryotic cells, especially mammalian.... Agent: Alston & Bird LLP

20070224659 - Harmful substance evaluating method and harmful substance evaluation kit: A biological growth inhibition factor assay method includes: a first step of mixing a photosynthetic sample, with an aqueous solution sample to prepare a test measurement solution, letting the test measurement solution stand, and then after illuminating light onto the test measurement solution for a predetermined illumination time, measuring the... Agent: Drinker Biddle & Reath (dc)

20070224660 - Method for assessment of cytotoxic t lymphocyte activity: A new cytotoxic T lymphocyte (CTL) assay has been discovered using two cell lines that stably express either green fluorescent protein (GFP) or red fluorescent protein (DsRed), which are distinguishable by FACS, fluorescence microplate reader, or fluorescence microscopy. Using one cell line as a target (T) to present antigen and... Agent: Patent Department Taylor, Porter, Brooks & Phillips, L.l.p

20070224663 - Human secreted proteins: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors,... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070224661 - Method for producing unsaturated omega-3-fatty acids in transgenic organisms: The present invention relates to a process for production of unsaturated ω-3-fatty acids and to a process for production of triglycerides with an elevated content of unsaturated fatty acids, especially of ω-3-fatty acids having more than three double bonds. The invention relates to the production of a transgenic organism, preferably... Agent: Connolly Bove Lodge & Hutz, LLP

20070224662 - Post-translational modification of proteins in cell-free expression systems: Disclosed is a method for post-translational modification of a recombinant protein in a cell-free expression system. The method comprises co-expressing the enzyme responsible for the post-translational modification along with the target protein in a prokaryotic based in vitro expression system. In one embodiment the expression system further comprises a eukaryotic... Agent: Roche Diagnostics Operations Inc.

20070224665 - Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules: Compositions of modified cytokines and uses thereof generated using processes and systems for the high throughput directed evolution of peptides and proteins, particularly cytokines that act in complex biological settings, are provided. Also provided are modified cytokines formulated for oral delivery and uses thereof to treat diseases and conditions mediated... Agent: Fish & Richardson, PC

20070224664 - System for antibody expression and assembly: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can... Agent: Merchant & Gould PC

20070224666 - Alleles of the zwf gene from coryneform bacteria: The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.... Agent: Law Office Of Michael A. Sanzo, LLC

20070224667 - Method of making theanine: In a method of making theanine, glutaminase is derived from microbes of one or more of Bacillus, mold and yeast is caused to act on glutamine and ethylamine derivative.... Agent: Burr & Brown

20070224668 - Process for producing 4-vinylguaiacol by biodecaroxylation of ferulic acid: 4-vinylguaiacol is produced using recombinant E. coli containing a decarboxylase gene from Bacillus pumilis in an aqueous fermentation broth and in an immobilized whole cell system. The 4-vinylguaiacol is extracted and recovered from an organic hydrocarbon solvent, preferably n-octane, whereby the product can readily be separated.... Agent: George A. Seaby Seaby & Associates

20070224669 - Self-pressurizing, self-purifying system and method for methane production by anaerobic digestion: Methane is produced using self-pressurizing, self-purifying system (2) and method, which converts a biomass into a biogas using anaerobic digestion. The anaerobic digestion is conducted in a bioreactor (4) that is maintained at a near constant pressure. The biogas that is generated is separated into a non-methane gas and a... Agent: Jones, Tullar & Cooper, P.C.

20070224670 - Chondroitinase abc i and methods of production: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans... Agent: Wolf Greenfield & Sacks, P.C.

20070224671 - Inhibitors of serine protease activity methods and compositions for treatment of nitric oxide-induced clinical conditions: A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having... Agent: Don D. Cha

20070224672 - Method of identifying inhibitors of dhodh: The present invention provides a compound capable of binding to the ubiquinone binding site of DHODH which contains a non-aromatic ring system as a core structure, a group capable of interacting with structural elements of subsite 2 or 3 of the ubiquinone binding site of DHODH and a group capable... Agent: Womble Carlyle Sandridge & Rice, PLLC Attn: Patent Docketing 32nd Floor

20070224673 - Proteases and variants thereof: The present invention relates to isolated proteases of the RP-II type and variants of RP-II proteases exhibiting improved properties in comparison to the parent RP-II protease, DNA constructs and vectors coding for the expression of said proteases and variants, host cells capable of expressing the proteases and variants from the... Agent: Novozymes North America, Inc.

20070224674 - Selective enrichiment of microorganisms for desired metabolic properties: A method for selectively enriching for a microorganism able to metabolise a test substrate, and/or the enrichment of an enzyme involved in the metabolism of the test substrate, the method comprising the steps of: a) providing a population of microorganisms in a vessel, b) feeding fluid into the vessel at... Agent: Ladas & Parry

20070224675 - Expression cassette: An expression cassette comprises targeting sites flanking a Cre fusion gene and a Cre coding sequence interrupted by an intron. This cassette can be used for the generation CreAoxP constructs and to reduce toxicity caused by the over-expression of Cre in target cells.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070224676 - Expandable culture roller bottle: The present invention provides a roller bottle for cell growth culturing, the roller bottle including a bottom wall; a top wall having an opening formed therethrough; and, a side wall extending between the top and bottom walls, a plurality of corrugations being defined in the side wall. Further, a distance... Agent: David W. Highet Vp & ChiefIPCounsel Becton, Dickinson And Company

20070224677 - Method for creating perfusable microvessel systems: Microvessel networks are produced in vitro from tissue-engineered parent vessels sprouting into a supporting matrix, as for example gels, of extracellular matrix proteins. The microvessel systems are integrated into devices that allow for controlled perfusion with fluids. The vessels may include cells from one cell type, for example, endothelial cells,... Agent: George A Leone, Sr Citadel Patent Law

20070224678 - Functionalized artificial bone and joint compositions and methods of use and manufacture: The present invention provides a functionalized ceramic body for in vitro and in vivo use comprising a calcium aluminate containing phase that is functionalized with a linker group comprising at least one of an organic acid molecule, a phosphonic acid, an amine, and N,N-dicyclohexylcarbodiimide for providing a reactive location for... Agent: Craig G. Cochenour, Esq. Buchanan Ingersoll & Rooney PC

20070224679 - Lentiviral triplex dna, and vectors and recombinant cells containing lentiviral triplex dna: The present invention provides nucleic acid, vectors, viruses, and recombinant cells comprising triple-stranded structures, such as those resulting from central initiation and termination of HIV-1 reverse transcription at the center of HIV-1 linear DNA genomes. These triplex structures can act as a cis-determinant of HIV-1 DNA nuclear import, allowing infection... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070224680 - Vehicle to transport a dna-modifying enzyme to a genome: A vehicle to transport a DNA-modifying enzyme towards a desired site in the genome, the DNA-modifying enzyme being coupled to a sequence recognizer that is specific for the desired site in the genome in such a way that the enzyme is able to perform its activity bound to the desired... Agent: Peacock Myers, P.C.

20070224681 - Collapsin response mediator protein-1 (crmp-1) transcriptional regulatory nucleic acid sequences: This invention provides a transcription unit which is isolated from the upstream nucleic acid sequence of the collapsing response mediator protein-1 (CRMP-1) gene, an invasion-suppressor gene. The transcription unit contains a nucleic acid regulatory sequence which demonstrates promoter and/or regulatory activities (such as providing a transcription factor binding site) to... Agent: Bingham Mccutchen LLP

20070224682 - High density growth of t7 expression strains with auto-induction option: Disclosed is a method for promoting auto-induction of transcription of cloned DNA in cultures of bacterial cells grown batchwise, the transcription being under the control of a promoter whose activity can be induced by an exogenous inducer whose ability to induce said promoter is dependent on the metabolic state of... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory

20070218451 - Peroxisome-proliferator activated receptor-alpha agonists for organ preservation: Methods and compositions for reducing, preventing or reversing organ damage and/or enhancing organ preservation by administration of a peroxisome-proliferator activated receptor-alpha (PPARα) agonist to the organ.... Agent: Leydig Voit & Mayer, Ltd

20070218473 - Method and apparatus for searching gene sequence: A method and apparatus for searching a gene sequence. The gene sequence search method includes receiving the gene sequence from a user, generating extended sequences including the received gene sequence, partial sequences included in the gene sequence and an inverse sequence complementary to the gene sequence, storing the gene sequence,... Agent: Cantor Colburn, LLP

20070218464 - Method for detecting a target nucleic acid sequence: A method of detecting a target nucleic acid sequence comprising providing a stem-and-loop structured nucleic acid for measurement wherein the nucleic acid comprises complementary sequence portions located at both terminals and a target sequence portion therebetween as well as a double-stranded portion formed by hybridization of the complementary sequence portions... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070218468 - Method for detecting the presence of water born pathogens and indicator microorganism: The present invention relates to a method for detecting the presence of water born pathogens and indicator microorganism including bacteria from water sample by selecting the target gene carried in template DNA by amplifying the target DNA using specific primers with biotinylated tag consist of all or a substantial part... Agent: Edwards Angell Palmer & Dodge LLP

20070218481 - Method for identifying drug-sensitizing antisense dna fragments and use thereof: The invention provides a method for generating and selecting drug-sensitizing antisense DNA fragments. In one embodiment, the method includes identifying a gene of interest using knowledge of bacterial physiology, biochemistry, genetics, genomics, and other means. The method includes PCR amplification of a gene of interest using genomic DNA as a... Agent: Dla Piper US LLP

20070218495 - Methods, libraries and computer program products for gene silencing with reduced off-target effects: The present invention provides methods, libraries and computer program products for selecting siRNA that reduce off-target effects and methods for gene silencing using these siRNAs. By comparing nucleotide sequences at positions 2-7 or 2-8 of the sense and/or antisense regions of candidate siRNAs to the 3′ UTR region of mRNAs,... Agent: Kalow & Springut LLP

20070218466 - Mxa as an antiviral drug and as a target for identification of antiviral drugs for dna virus infections: The invention features methods and compositions for use in a screening assay to identify agents having antiviral activity against a DNA virus by assessing the effect of a candidate agent upon alternative splicing of MxA, or by assessing the effect of a candidate agent on production of a variant form... Agent: Bozicevic, Field & Francis LLP

20070218465 - Therapeutic applications of aminolevulinate synthase: Systems and methods for increasing protoporphyrin IX accumulation in a target cell population using aminolevulinate synthase variants. Aminolevulinic acid-mediated photodynamic therapy is a promising approach to treating dysplasic disorders such as cancer and atherosclerosis, but is limited by the lack of a means to deliver optimal quantities of aminolevulinic acid... Agent: Smith Hopen, Pa

20070218456 - Cellular assays for signaling receptors: The present invention provides cells and methods related to signaling receptors. The cells of the invention express the signaling receptors (e.g., in a constitutively active state). The cells are useful for analyzing the signaling receptors and their related pathways. The invention further provides methods for studying interactions of the signaling... Agent: Invitrogen Corporation C/o Intellevate

20070218454 - Optical detection cell for micro-fluidics: The present invention relates to an optical detection cell for micro-fluidics. The detection cell provides a first layer, a detection cell layer contacting the first layer, a third layer contacting the detection cell layer and a detection channel defined through the detection cell to serve as a light path for... Agent: Agilent Technologies Inc.

20070218452 - Process for distributing drops of a liquid of interest onto a surface: The present invention relates especially to a process for the localized distribution of drops of a liquid of interest on an active surface. The process comprises the following steps an introduction of liquid of interest into a box containing the said active surface, and an extraction of liquid of interest... Agent: Mckenna Long & Aldridge LLP

20070218455 - Sample preparation of biological cells for analysis: A system for reliably and reproducibly exposing the contents of a biological cell to an analysis instrument comprising a sample handling unit that includes a first substrate with first substrate face and a second substrate with second substrate face. The first substrate face and the second substrate face are opposed.... Agent: Eddie E. Scott Assistant Laboratory Counsel

20070218453 - Sensing tool: This invention relates to a hollow-nanoparticle-based biosensing tool, which comprises proteins capable of forming nanoparticles through the incorporation of a lipid bilayer and specific biorecognition molecules bound thereto and a biosensing method using such tool.... Agent: Kubovcik & Kubovcik

20070218457 - Toxicity screening methods: The present invention provides methods of determining a level of toxicity of a given compound based on in vitro assays. The present invention provides particular methods of determining organ-specific toxicity and species-specific toxicity of a given compound based on in vitro assays. In addition, the present invention provides methods of... Agent: Dunlap, Codding & Rogers P.C.

20070218458 - Method for removal of viruses from blood by lectin affinity hemodialysis: The present invention relates to a method for using lectins that bind to pathogens having high mannose surface glycoproteins or fragments thereof which contain high mannose glycoproteins, to remove them from infected blood or plasma in an extracorporeal setting. Accordingly, the present invention provides a method for reducing viral load... Agent: Knobbe Martens Olson & Bear LLP

20070218472 - Association of pde4d allelic variants with stroke: The present invention provides methods for detecting a predisposition for stroke in individuals by correlating allelic variants of the phosphodiesterase 4D (PDE4D) gene and hypertension status. The invention further contemplates kits and computer program products for detecting PDE4D polymorphisms indicative of a predisposition for stroke correlated with an individual's hypertension... Agent: Townsend And Townsend And Crew, LLP

20070218485 - Biological bar code: The invention provides compositions and methods useful for identifying, verifying or authenticating any type of sample, whether the sample, is biological or non-biological.... Agent: Pillsbury Winthrop Shaw Pittman LLP

20070218494 - Branched polymer lables as drag-tags in free solution electrophoresis: End Labelled Free Solution Electrophoresis (ELFSE) provides a means of separating polymer molecules such as ssDNA according to their size, via free solution electrophoresis, thus eliminating the need for polymer separation via gels or polymer matrices. Here, end labels are provided that optimize branching architecture to increase hydrodynamic drag of... Agent: Kirby Eades Gale Baker

20070218477 - Circular probe amplification (cpa) using energy-transfer primers: The present invention provides methods and kits for the rapid exponential amplification of nucleic acid molecules using a padlock probe. The present invention improves upon the existing methods for amplifying padlock probes by eliminating or delaying the appearance of artifact products that cause false positive results, and also increase the... Agent: Philip S. Johnson Johnson & Johnson

20070218489 - Compositions for use in identification of bacteria: The present invention provides compositions, kits and methods for rapid identification and quantification of bacteria by molecular mass and base composition analysis.... Agent: Medlen & Carroll LLP

20070218480 - Detection and diagnosis of smoking related cancers: Gene probes for specific regions of chromosomes 1, 3, 9, 10 and 17 are now shown to be useful in the diagnosis and prognosis of smoking related cancers such as non-small cell lung cancer (NSCLC). For example, these probes can be used with fluorescence in situ hybridization (FISH), and used... Agent: Fulbright & Jaworski L.L.P.

20070218482 - Diagnostic assay for lung transplant: Methods and compositions for determining the suitability of a lung for transplantation are described.... Agent: Bereskin And Parr

20070218493 - Diagnostic marker for interferon responsiveness in multiple sclerosis: Disclosed is a method of determining interferon responsiveness in a patient suffering from multiple sclerosis. The method comprises determining an amount of a XAF-1 gene expression level in a blood sample, which is obtained from the patient undergoing interferon therapy. The amount of the XAF-1 gene expression level in the... Agent: Philip Swain, Phd C/o Gowling Lafleur Henderson

20070218459 - Diagnostic system for otolaryngologic pathogens and use thereof: The present invention relates to a method of detecting the presence of an otolaryngologic pathogen in a biological sample, and a sensor device, sensor chip, and nucleic acid probes useful for detecting otolaryngologic pathogens.... Agent: Nixon Peabody LLP - Patent Group

20070218475 - Efficient drug screening for protein targets: The methods of the invention allow extremely high throughput screening of chemicals against a large number of pharmacologically relevant targets. All of the pharmacologically relevant targets are expressed in cells, which are then screened against a fluorescently-tagged combinatorial library. Binding of the small molecules to the cells is then detected... Agent: Dla Piper US LLP

20070218484 - Feature quality in array fabrication: A method, and apparatus and computer program products for executing the method. The method includes obtaining a set of multiple images of a target feature location on an array of multiple features, each image of the set representing the target feature location following deposition of a corresponding sub-set of multiple... Agent: Agilent Technologies Inc.

20070218487 - Genetic markers for predicting disease and treatment outcome: The present invention provides for a method for identifying patients that are suitably treated by a therapy, such as a therapy involving administration of a fluoropyrimidine drug and/or a platinum drug. The method includes determining the expression level of at least one gene selected from a phospholipase 2 (PLA2) gene,... Agent: Foley & Lardner LLP

20070218476 - Identifying organisms by detecting intronic nucleic acid or encoded proteins: The present invention provides novel methods for characterizing organisms by identifying the presence, absence, size or sequence polymorphism of intronic regions. The method involves selecting intronic regions from nuclear or organellar gene sequences that are useful for differentiating between and among taxonomic groupings of organisms. Such intronic regions can be... Agent: Gordon & Rees LLP

20070218486 - Immunoassays, haptens, immunogens and antibodies for anti-hiv therapeutics: This invention provides compounds, methods, immunoassays, and kits relating to active, metabolically sensitive (“met-sensitive”) moieties of anti-HIV therapeutics, such as HIV protease inhibitors (PI), HIV nucleoside reverse transcriptase inhibitors (NRTI) and HIV entry inhibitors (EII).... Agent: Morgan, Lewis & Bockius LLP (sf)

20070218461 - Indole-diterpene biosynthesis: The present invention relates to the biosynthesis of indole diterpene compounds. In particular, the invention relates to genes encoding enzymes considered responsible for the synthesis of lolitrems.... Agent: Knobbe Martens Olson & Bear LLP

20070218471 - Method and device for detecting dna using surface-treated nanopore: Disclosed herein is a method for detecting DNA using a nanopore including treating the surface of a nanopore formed in a solid substrate with a substance carrying positive charges; introducing a DNA-containing sample into the surface-treated nanopore; and detecting electrical signals generated during translocation of the sample through the nanopore.... Agent: Cantor Colburn, LLP

20070218496 - Method for quick determination of cytokeratin 19 (ck19) and primers and probes therefore: A method for determination of CK19 mRNA is provided characterized in that a part of CK19 mRNA is amplified using a first primer hybridizing to a region located on a first exon of the CK19 gene and a second primer hybridizing to a region located on a second exon of... Agent: Roche Molecular Systems Inc Patent Law Department

20070218470 - Method for selective inactivation of viral replication: Method for screening for an antiviral agent, by determining whether a potential agent interacts with a virus or cellular component which allows or prevents preferential translation of a virus RNA compared to a host RNA under virus infection conditions; and determining whether any interaction of the agent with the component... Agent: Bozicevic, Field & Francis LLP

20070218460 - Method of estimating toxicity of drug: The present invention provides a novel in vitro prediction system of a phospholipidosis inducing potential of a novel drug-caused phospholipidosis marker gene and a drug. Specifically, the invention provides a reagent for prediction of a phospholipidosis inducing potential of a compound containing a nucleic acid capable of detecting the expression... Agent: Edwards Angell Palmer & Dodge LLP

20070218462 - Method of predicting a benefit of antioxidant therapy for prevention of cardiovascular disease in hiperglycemic patients: A method of determining a potential of a diabetic patient to benefit from anti oxidant therapy for treatment of a vascular complication, the method comprising determining a haptoglobin phenotype of the diabetic patient and thereby determining the potential of the diabetic patient to benefit from said anti oxidant therapy, whereby... Agent: Pearl Cohen Zedek Latzer, LLP

20070218492 - Methods for detecting ovarian cancer and anticipating chemotherapy response: The disclosure relates to methods of detecting cancer and evaluating risk of cancer. The disclosure also relates to methods of predicting patient response to chemotherapy. The disclosure further relates to the use of a single nucleotide polymorphism in the human AFAP gene for the preparation of a diagnostic compounds for... Agent: Craig G. Cochenour, Esq. Buchanan Ingersoll & Rooney PC

20070218478 - Methods for fragmentation and analysis of nucleic acid: Methods for fragmenting and labeling DNA in a single reaction volume and incubation step using a uracil DNA glycosylase, an apurinic/apyrimidinic endonuclease, and a terminal transferase are disclosed. In a preferred embodiment the UDG, AP and TdT activities are first mixed together to form an enzyme mixture and then the... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070218467 - Methods for rapid identification and quantitation of nucleic acid variants: There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass... Agent: Medlen & Carroll LLP

20070218479 - Microrna precursors: Disclosed are methods of identifying microRNA motifs or microRNA precursors for a target gene or a set of target genes. Also disclosed are related computer-readable media... Agent: Fish & Richardson PC

20070218474 - Multiplex pcr assay: This invention relates to a multiplex PCR assay capable of screening or detecting the relevant microbial organism specific to Mycobacterium tuberculosis, Toxoplasma gondii, pathogenically important fungii and cytomegalo virus (CMV) in a sample, comprising a reaction mixture of a combination of 4 sets of primers, one of said primer for... Agent: Venable LLP

20070218469 - Novel mutations in hexosaminidase a: The present invention discloses methods and compositions for detecting novel mutations in the α chain of the hexosaminidase gene. These methods facilitate rapid screening for Tay-Sachs disease carriers, especially in the Ashkenazi Jewish population. The novel mutations include the single nucleotide substitutions 638A>C and 181C>T.... Agent: Nath & Associates, PLLC

20070218490 - Nucleic acid monomers with 2'-chemical moieties: The invention provides nucleic acid monomers with a 2′-modification that are useful for the incorporation of dyes or blocking groups. The monomers can be incorporated on the 3′-end of a dual labeled probe to inhibit PCR polymerase extension during PCR. The polymerase is inhibited from extending the probe at the... Agent: John Petravich Integrated Dna Technologies, Inc.

20070218491 - Oligomerization of amyloid proteins: The present invention provides methods and, accordingly, in vitro systems for generating stable and soluble oligomers of amyloid proteins, under physiological pH and temperature; and hence, a system for identifying and validating drugs that have the potential to prevent formation of soluble oligomers of amyloid proteins, to disaggregate soluble oligomers... Agent: Davidson, Davidson & Kappel, LLC

20070218463 - Rearranged squamous cell carcinoma antigen genes ii: The present invention relates to a SCCA1/SCCA2 fusion protein; plasmid containing the same; antibodies of said fusion protein; methods for detecting said protein; methods for diagnosing the presence or absence of SCC by determining the presence of SCCA1/SCCA2 fusion protein.... Agent: Samuels, Gauthier & Stevens LLP

20070218483 - Site-specific incorporation of fluorinated amino acids into proteins: This invention relates, in part, to newly identified polynucleotides, polypeptides, variants and derivatives thereof; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; and uses of the polynucleotides, polypeptides, variants and derivatives. The invention also relates to compositions of orthogonal aminoacyl-tRNA synthetases, and pairs of orthogonal... Agent: Mcnees Wallace & Nurick LLC

20070218501 - Assays to predict atherosclerosis and dysfunctional high-density lipoprotein: This invention provides novel assays for the detection of dysfunctional HDL. The assays are good diagnostics and/or prognostics for atherosclerosis or other pathologies characterized by an inflammatory response. In certain embodiments the methods involve measurements of heme-related HDL-associated proteins (e.g., haptoglobin, hemopexin, etc.), and/or measurements of the relative distribution of... Agent: Beyer Weaver LLP

20070218504 - Human leptin-derived polypeptides and uses thereof: A polypeptide that contains an amino acid sequence present in human leptin blocks the inhibitory effect of human C-Reactive Protein on human leptin. Accordingly, such a polypeptide is implicated in an approach to treating or preventing conditions associated with the impact of CRP on leptin.... Agent: Foley And Lardner LLP Suite 500

20070218505 - Identification of biomolecules through expression patterns in mass spectrometry: Systems, methods, apparatus, and computer programming useful in identifying proteins, peptides, carbohydrates, and other biomolecules, or for a validation of an identification of proteins, peptides, carbohydrates, and other biomolecules, is described. In particular, the invention provides systems, methods, apparatus, and programming useful for identifying proteins and other precursor biomolecules using... Agent: Torys LLP

20070218506 - Immunoassays for buprenorphine and norbuprenorphine: Methods, compositions and kits are disclosed directed at haptens, immunogens and immnoassays for buprenorphine (BUP) and nor buprenorphine (norBUP). The method comprises providing in combination in a medium (i) a sample suspected of containing buprenorphine (BUP) or norbuprenorphine (norBUP) and (ii) an antibody raised against an immunogen of buprenorphine (BUP)... Agent: Dade Behring Inc. Legal Department

20070218502 - Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation: The invention provides peptide synthons having protected functional groups for attachment of desired moieties (e.g. functional molecules or probes). Also provided are peptide conjugates prepared from such synthons, and synthon and conjugate preparation methods including procedures for identifying optimum probe attachment sites. Biosensors are provided having functional molecules that can... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20070218500 - Method and apparatus for detection of live bacterium within test subject through specifically labeling thereof: A method and apparatus for detection whereby live bacteria among microbes as an antigen can be detected rapidly in a short period of time through specifically labeling of live bacteria within a test subject antigen and whereby testing assurance can be ensured. The method and apparatus are characterized in that... Agent: Sughrue Mion, PLLC

20070218503 - Methods of polypeptide identification, and compositions therefor: Methods are disclosed for identifying one or more proteins or polypeptides comprised by a sample. The methods comprise determining binding of each polypeptide with respect to each binding pool of a plurality of binding pools, wherein each binding pool comprises one or more probes which bind a structure comprised by... Agent: Washington University C/o Sonnenschein Nath & Rosenthal L.l.p

20070218499 - Monoclonal antibodies that target pathological assemblies of amyloid b (abeta): Disclosed herein are antibodies that bind with high specificity to soluble oligomers of amyloid β (Abeta) and methods of employing those antibodies. The antibodies are able to distinguish between Alzheimer's Disease (AD) and control human brain extracts. The antibodies identify endogenous Abeta oligomers in AD brain slices and also bind... Agent: Licata & Tyrrell P.C.

20070218497 - Quick test for the diagnosis of alzheimer's disease: The invention relates to method for the diagnosis of Alzheimer's disease or the early stages thereof or a predisposition to said disease. Said method is based on quantitative determination of a mitogenically expressible surface marker, in particular CD69, and peripherally accessible cells, e.g. skin cells or lymphocytes, (a) prior to... Agent: Intellectual Property / Technology Law

20070218498 - Use of soluble flt-1 and its fragments in cardiovascular conditions: The present invention relates to materials and procedures for evaluating patients suffering from cardiovascular conditions, particularly acute coronary syndromes. In particular, an assay configured to measure the level of soluble FLT-1 in a patient sample, alone or in combination with one or more other markers, provides diagnostic and/or prognostic information.... Agent: Richard J. Warburg Foley & Lardner LLP

20070218508 - Detection and amplification of ligands: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an... Agent: Hahn Loeser & Parks, LLP

20070218507 - Inhibitor of apoptosis proteins and nucleic acids and methods for making and using them: The invention provides polypeptides comprising inhibitor of apoptosis protein (IAP) family members, such as BmIAP initially derived from Bombyx mori BmN cells, and nucleic acids encoding them, and methods for making and using these compositions, including their use for inhibiting apoptosis.... Agent: Needle & Rosenberg, P.C.

20070218509 - Murine living tissue model & usestthereof: The invention provides an in vitro method for observing an effect of a test agent on a murine tumour model. The model consists a three-dimensional array of murine fibroblasts in a collagen gel which mimics a connective tissue substrate, on or in which are grown benign or malignant murine tumour... Agent: Morgan Lewis & Bockius LLP

20070218511 - Methods for the diagnosis and treatment of lung cancer: The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell, and methods of screening for a potential therapeutic agent for the reversal of the neoplastic condition.... Agent: Foley & Lardner LLP

20070218512 - Methods related to mmp26 status as a diagnostic and prognostic tool in cancer management: Disclosed herein are compositions and methods involving identifying MMP-26 in a subject with cancer.... Agent: Needle & Rosenberg, P.C.

20070218510 - Use of protein psa3 as a marker for colorectal cancer: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein proteasome subunit alpha 3 (PSA3) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring PSA3 in said... Agent: Roche Diagnostics Operations Inc.

20070218514 - Diagnostic methods relating to graves' disease and other autoimmune disorders: The invention provides methods of diagnosing Graves' disease (GD), Rheumatoid Arthritis (RA) and other autoimmune diseases in an individual by detecting a disproportionately large fraction of peripheral blood T cells express IGF-1R (CD3+ IGF-R+) compared to normal control samples. In a further embodiment, the invention provides methods of diagnosing, prognosing,... Agent: Mcdermott, Will & Emery

20070218513 - Differentially expressed genes related to coronary artery disease: The present invention relates to genes whose expression is correlated to the prevalence of coronary artery disease. In particular, the invention relates to methods of prognosis, diagnosis and methods of monitoring coronary artery disease based on the measurement of gene expression. In addition, the present invention relates to methods of... Agent: Novartis Corporate Intellectual Property

20070218515 - Method and kits for the determination of the antigens on the red blood cells and antibodies of serum: The Present invention relates to biological test methods using micro trays for determining red blood cell antigens and corresponding antibodies of the serum or plasma from individuals using cell aggregation analysis method. This invention also relates to kits for determining red blood cell typing, wherein the kits including mixture monoclonal... Agent: Nina Zhou

20070218517 - Methods for comparing the immunogenicity of products and uses thereof: The present invention relates to methods of determining the immunogenic potential of a test product by comparing the immunogenic profile or fingerprint of the test product to the immunogenic profile or fingerprint of a reference product.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070218516 - Recombinant chimeric human anti-botulinum antibodies: In this application is described the production of recombinant, chimeric, humanized antibodies specific for both BoNt/A and BoNT/B. The humanized antibodies were converted from a mouse anti-BoNT/A/B Fab fragment into a whole human IgG1 antibody. The antibodies are useful in assays for detecting human exposure to BoNT/A and BoNT/B.... Agent: U.s. Army Medical Research And Materiel Command Attn: Mcmr-ja (ms. Elizabeth Arwine- Patent Atty)

20070218518 - Host receptor for pathogenic bacteria: A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events... Agent: Woodcock Washburn LLP

20070218519 - Diabetes-associated markers and methods of use thereof: Disclosed are methods of identifying subjects with Diabetes or a pre-diabetic condition, methods of identifying subjects at risk for developing Diabetes or a pre-diabetic condition, methods of differentially diagnosing diseases associated with Diabetes or a pre-diabetic condition from other diseases or within sub-classifications of Diabetes, methods of evaluating the risk... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20070218520 - Method for measuring binding of a test compound to a g-protein coupled receptor: The invention provides a method for measuring binding of a test compound to a G-Protein Coupled Receptor (GPCR). The invention also provides a method for identifying and measuring the effect that an agent has upon modulating the binding of a test compound to a G-Protein Coupled Receptor.... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070218521 - Medium for identification of micro-organisms: Disclosed is a medium for the detection and/or identification of a Candida yeast, the medium comprising: a chromogen; carbohydrate in the range 1-5 gms/litre; and an alcohol; the medium being such that growth of the Candida yeast under appropriate conditions results in hydrolysis of the chromogen to generate a chromophore... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070218522 - Methods and compositions for rapidly detecting and quantifying viable legionella: Methods and compositions detect and quantify viable Legionella and other heterotrophic aerobic bacteria. Dip-slides that include an absorbent medium, growth promoting, and growth selective substances are useful in rapid detection and quantification of microcolonies of Legionella. Most probable number method of detection and quantification of Legionella are disclosed.... Agent: Barnes & Thornburg LLP

20070218526 - Method for zymotic production of fine chemicals containing sulphur (meta): The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (meta) gene.... Agent: Connolly Bove Lodge & Hutz, LLP

20070218523 - Modified human thymic stromal lymphopoietin: Modified, furin resistant human TSLP polypeptides and polynucleotides encoding the modified human TSLP polypeptides are provided. Pharmaceutical compositions, B and T cell activation agents, assays and methods of use are also described.... Agent: Immunex Corporation Law Department

20070218524 - Polypeptide having rnase iii activity: A polypeptide having an RNase III activity with which the length of a dsRNA degradation product can be easily controlled depending on reaction conditions and, in preparing a dsRNA having a length allowing it to serve as an siRNA in RNA interference, a low-molecular weight product having little RNA interferring... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070218525 - Process for producing dipeptides: The present invention provides a process for producing a dipeptide other than D-alanyl-D-alanine and D-alanyl-D-serine using, as an enzyme source, a culture of a microorganism having the ability to produce a protein having D-alanine-D-alanine ligase activity or a treated matter of the culture, and a process for producing a dipeptide... Agent: Nixon & Vanderhye, PC

20070218527 - Tryptophanyl-trna synthetase-derived polypeptides useful for the regulation of angiogenesis: The invention provides an isolated nucleic acid encoding a water-soluble polypeptide fragment of human tryptophanyl-tRNA synthetase, which is useful for the inhibition of angiogenesis. The nucleic acid comprises a polynucleotide of SEQ ID NO: 6, a polynucleotide hybridizable to SEQ ID NO: 6, a polynucleotide that encodes the polypeptide of... Agent: Olson & Hierl, Ltd.

20070218528 - Methods and compositions for targeted cleavage and recombination: Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered... Agent: Robins & Pasternak

20070218530 - Methods for enzymatic hydrolysis of lignocellulose: Compositions and methods for biomass conversion are provided. Compositions comprise novel enzyme mixtures that can be used directly on lignocellulose substrate. Methods involve converting lignocellulosic biomass to free sugars and small oligosaccharides with enzymes that break down lignocellulose. Novel combinations of enzymes are provided that provide a synergistic release of... Agent: Alston & Bird LLP

20070218529 - Non-reducing saccharide-forming enzyme, trehalose-releasing enzyme, and process for producing saccharides using the enzymes: A non-reducing saccharide-forming enzyme and a trehalose-releasing enzyme, which have an optimum temperature in a medium temperature range, i.e., a temperature of over 40 or 45° C. but below 60° C.; and an optimum pH in an acid pH range, i.e., a pH of less than 7. The two-types of... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070218531 - Micro-organism and a method of producing paclitaxel by the use of the same: There is provided a new strain, i.e. the alternaria alternata var. monosporus ST-026R CGMCC No. 0899, and its use in the production of paclitaxel. The invention also provides a method for the production of paclitaxel by using the strain CGMCC No. 0899.... Agent: Birch Stewart Kolasch & Birch

20070218532 - Novel escherichia coli having accession no. pta 1579 and its use to produce polyhydroxybutyrate: The present invention provides a novel genetically modified Escherichia coil JM109 bearing accession number PTA 1579, containing the gene coding for poly-beta-hydroxybutyrate synthesis and a method of using this bacterium to produce poly-beta-hydroxybutyrate to the extent of 60% or more of the cell weight.... Agent: Baker Botts L.L.P.

20070218533 - Enhanced alcohol tolerant microorganism and methods of use thereof: Embodiments of the present invention provide methods and compositions for microorganisms having increased alcohol tolerance. In certain embodiments, methods for using such microorganisms, and methods for identifying gene or genetic regions responsible for increased alcohol tolerance are contemplated.... Agent: Faegre & Benson LLP Patent Docketing

20070218534 - Measurement and use of molecular interactions: The present invention is based on the realization that the bonds between a target molecule, or a target molecule attached to a particle, and a surface, can be ruptured by mechanically oscillating the surface at increasing amplitude, leading to detachment of the target molecule or particle from the surface. The... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070218535 - Methods for production of recombinant alpha1-antitrypsin: Methods of producing properly folded recombinant α1-antitrypsin (AAT) polypeptide are provided. Denatured recombinant AAT polypeptide is refolded by first solubilizing the polypeptide with a chaotroph at high pH, followed by refolding in the presence of reduced concentrations of chaotroph and in the presence of PEG, glycerol or sucrose, or a... Agent: Morrison & Foerster LLP

20070218536 - Polyvalent viral vectors and a system for production thereof: A system for generating viral vectors carrying two distinct expression cassettes is provided. The system utilizes a unique polyvalent transfer vector that permits efficient detection and selection of inserted expression cassettes.... Agent: Howson And Howson

20070218537 - Method for treating ammonia-containing wastewater: A process for treating ammonia containing wastewater includes bringing an ammonia-treating material and ammonia containing wastewater into contact with each other to remove ammonia in the wastewater continuously as nitrogen gas, the ammonia-treating material including a long carrier and complex bacterial sludge attached and immobilized on the biomass carrier, the... Agent: The Webb Law Firm, P.C.

20070218538 - Polypeptides and bacterial strains for increased protein production: The invention provides polypeptides, nucleic acid sequences, bacterial strains, methods and kits for producing exogenous protein. More specifically, the invention provides RNase E polypeptides that posses impaired mRNA degrading activity and efficient rRNA and tRNA processing activity. These polypeptides may be utilized for producing exogenous protein.... Agent: Polsinelli Shalton Welte Suelthaus PC

20070218540 - Bioelectrolytic methanogenic/methanotrophic coupling for bioremediation of ground water: The invention disclosure is a method of bioremediation of wastewater, particularly groundwater, by utilizing coupled anaerobic and aerobic biological treatment, more specifically, methanogenic (strictly anaerobic) and methanotrophic (strictly aerobic) microbial populations, in combination with a supply of in-situ generated water-dissolved oxygen and hydrogen. Water electrolysis is used to produce water-dissolved... Agent: National Research Council Of Canada 1200 Montreal Road

20070218539 - Method for the degradation of mtbe and tba: A method for the degradation of methyl-tertiary-butyl-ether (MTBE) and tertiary-butanol (TBA) using a mixture of Pseudomonas putida is described. The method enables almost complete remediation of MTBE and TBA in situ in contaminated water and/or soil.... Agent: Ian C. Mcleod Mcleod & Moyne, P.C.

20070218541 - Fermenter and fermentation method: A method is described for treating a biomaterial waste stream to remove pollutants and to generate a product. The method comprises the steps of injecting the biomaterial waste stream into a waste fermentation system, contacting the biomaterial waste stream with a microorganism, and subjecting the biomaterial waste stream to conditions... Agent: Barnes & Thornburg LLP

20070218542 - Cytoblock preparation system and methods of use: An apparatus and method that may be used for collecting target cells or tissue and preparing a cell block are disclosed.... Agent: Rathe Patent &IPLaw

20070218543 - Analyte meter with rotatable user interface: In one embodiment the present invention provides a blood analyte meter that is user-friendly and easy to use. In accordance with an embodiment of the present invention an analyte measurement device, for use with a test strip for determining the amount of an analyte in a sample, displays a hierarchy... Agent: Marina Larson & Associates, LLC

20070218545 - Antibody chip, antigen measuring apparatus and liquid discharging method: It is an object to provide an antibody chip and a light source measuring apparatus which are excellent in a reproducibility and a workability of a measurement and can easily be utilized. A light source measuring apparatus (1) includes, as a main structure, a concentration measuring device (2), an antibody... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070218546 - Support plate for carrying out functional tests on biological cells and method for coating the support plate: The invention relates to a method for coating a support plate for carrying out functional tests on biological cells, to a support plate for carrying out functional tests on biological cells and to the use of corresponding support plates for carrying out functional tests on biological cells.... Agent: Morrison & Foerster LLP

20070218544 - Three-dimensional fabrication of biocompatible structures in anatomical shapes and dimensions for tissue engineering and organ replacement: The present invention relates to methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, to methods and apparatuses involving biocompatible structures formed by three-dimensional fabrication for tissue engineering and organ replacement. In some embodiments, the biocompatible structures are scaffolds for cells that can be... Agent: Wolf Greenfield & Sacks, P.C.

20070218549 - Compositions comprising conditioned cell culture media and uses thereof: The invention relates to compositions comprising cell culture medium conditioned by cells grown in three-dimensional culture. The cells used to condition the medium may be genetically modified to alter the concentration of growth factors and antioxidants in the medium. The conditioned cell medium (conditioned medium) may be used for at... Agent: Wilson Sonsini Goodrich & Rosati

20070218548 - Mesenchymal stem cell processor: A premesenchymal stem cell differentiated from a pluripotent stem cell in vitro which is positive for Sox1, and a method for the preparation of the same.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070218547 - Self assembling proteins for producing extended materials: Self-assembling fusion proteins and nucleic acids encoding the same are provided. The subject fusion proteins include a first dimer forming oligomerization domain and a second tetramer forming oligomerization domain rigidly linked to each other. Also provided are regular structures made up of a plurality of self-assembled fusion proteins of the... Agent: Bozicevic, Field & Francis LLP

20070218550 - Novel human lxralpha variants: This invention provides novel human LXRα variant polypeptides and nucleic acids encoding such polypeptides. This invention also provides the therapeutic, diagnostic, and research utilities as well as the production of such polynucleotides and polypeptides. It is emphasized that this abstract is provided to comply with the rules requiring an abstract... Agent: Wilmerhale/wyeth

20070218551 - Novel sirna-based approach to target the hif-alpha factor for gene therapy: The presently disclosed subject matter provides vectors that encode small interfering RNAs (siRNAs) designed to down regulate the expression of hypoxia-inducible genes in a cell. Also provided are compositions and host cells based upon the vectors, as well as methods of using the vectors. The presently disclosed subject matter further... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20070218552 - Method for producing red blood cells: The invention relates to a method for the expansion and differentiation of haematopoietic stem cells into enucleated erythrocytes, in two steps: a first step in a culture medium, where cell proliferation and erythroid differentiation are induced in the presence of growth factors, and a second step modeling a reconstitution of... Agent: Young & Thompson

20070218553 - Cell separation apparatus: An apparatus 20 for the separation of a subpopulation of cells from an intact organ or other biological material is provided. The apparatus 20 includes: (1) a digestion chamber 24 that integrates the primary digestion process, (2) a measuring cylinder 26, (3) a cell collection chamber 28, (4) a heat... Agent: Tucker Ellis & West LLP

20070218554 - Cell culture patterning substrate and method for manufacturing the same: A main object of the present invention is to provide a cell culture patterning substrate and a method for manufacturing the same, which can be used to culture the cells on the substrate in an intended shape. To achieve the object, the present invention provides a cell culture patterning substrate... Agent: Ladas & Parry LLP

20070218555 - Anti-microbial activity of biologically stabilized silver nano particles: An antimicrobial formulation containing biologically stabilized silver nano particles stabilized by a ‘green’ biological route with an average size 1-100 nm in a carrier in which the concentration is 1 to 6 ppm.... Agent: Hedman & Costigan P.C.

20070212680 - Safety approach for diagnostic systems: The present invention provides a diagnostic safety method, a diagnostic device, a computer program and a diagnostic system for analyzing a plurality of samples with regard to the presence of contaminations. More particular, the present invention provides a diagnostic safety method, a diagnostic device, a computer program and a diagnostic... Agent: Roche Molecular Systems Inc Patent Law Department

20070212741 - Diagnostic markers for sub-acute ruminal acidosis: A diagnostic method and kits for detecting sub-acute ruminal acidosis in livestock animals. The method comprises collecting a blood sample from a livestock animal, contacting the blood sample with a kit provided with at least one marker derived from at least one acute phase protein associated with inflammatory responses. The... Agent: Fasken Martineau Dumoulin LLP

20070212745 - Beta-glucosidase and a process for extraction thereof: The present invention provides a novel beta glucosidase and a process for extraction of a beta-glucosidase from Rauvolfia serpentine useful for the cleaving of beta-1,4 linkage of PNPG and to convert other gluco-conjugates such as strictosidine and raucaffricine into their corresponding aglycon such as vomilenine, commercially through immobilizing the enzyme.... Agent: Morgan & Finnegan, L.L.P.

20070212746 - Quantum dot nanoparticle-based universal neurotoxin biosensor: The present invention is directed to a quantum dot nanoparticle-based universal neurotoxin biosensor having three components (a) a dendrimer-encapsulated quantum dot nanoparticle; (b) acetylcholinesterase; and (c) an acceptor fluorophore, wherein the quantum dot nanoparticle and the acceptor fluorophore linked to the acetylcholinesterase.... Agent: Lucas & Mercanti, LLP

20070212674 - Blood co-processing for contingent autologous leukocyte transplantation: A process for producing a leukocyte bank suitable for CAT therapy comprising the steps of providing a blood sample from a healthy donor individual; selectively separating and collecting leukocytes from the sample; selectively separating and collecting red blood cells and/or platelets and/or plasma from the sample; and cryogenically preserving the... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP (formerly Kirkpatrick & Lockhart Nicholson Graham)

20070212679 - Assay for parkinson's disease therapeutics and enzymatically active parkin preparations useful therein: The invention provides to assays for agent useful for treatment of Parkinson's Disease. Included are cell-based assays for agents that modulate the effect of Parkin proteins on proteasome function. The invention also provides recombinant, enzymatically active, Parkin protein produced in prokaryotic expression systems, such as E. coli cells. Methods for... Agent: Townsend And Townsend And Crew, LLP

20070212675 - Flap endonuclease (fen1) regulatory sequences and uses thereof: FEN1 transcriptional regulatory sequences (TREs) are provided. FEN1 TREs provide for transcriptional regulation dependent upon transcription factors that are only active in cancer cells. The FEN1 TREs may be used as a vehicle for introducing new genetic capability, particularly associated with cytotoxicity, for selective expression in cancer cells.... Agent: Dla Piper US LLP

20070212677 - Identifying off-target effects and hidden phenotypes of drugs in human cells: This invention provides principles, methods and compositions for ascertaining the mechanism of action of pharmacologically important compounds in the context of network biology, across the entire scope of the complex pathways of living cells. Importantly, the principles, methods and compositions provided allow a rapid assessment of the on-pathway and off-pathway... Agent: Isaac A. Angres

20070212676 - Induction of myocardial cell from mammalian bone marrow cell or cord blood-derived cell and fat tissue: This invention provides a method for differentiating mammalian bone marrow cells or cord blood-derived cells into myocardial precursor cells and/or myocardial cells by culturing said bone marrow cells or cord blood-derived cells with cells isolated from mammalian fat tissues or a culture supernatant thereof.... Agent: Birch Stewart Kolasch & Birch

20070212678 - Method and apparatus for predicting aggregation kinetics of a biologically active material: A mechanistic model was developed to extract meaningful thermodynamic and kinetic parameters from an irreversibly denatured process. As a result, methods and computer apparatus have been created that can be used to mathematically determine parameters that are predictive of aggregation kinetics of biologically active materials. Those parameters can then be... Agent: Marshall, Gerstein & Borun LLP

20070212681 - Cell canaries for biochemical pathogen detection: Methods and compositions for the reliable detection of pathogens are presented. The invention uses cells as novel pathogen detection agents, exploiting pathogen-specific pathways and apoptosis.... Agent: Dykema Gossett PLLC

20070212683 - Co-crystals and pharmaceutical compositions comprising the same: The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of salicylic acid, 4-amino salicylic acid, and oxalic acid. Also within the scope of this invention are methods of making and using the same.... Agent: Jonathan P. O'brien

20070212684 - Diagnostic test kits: This invention provides kits, devices, and methods for the detection of antibodies that recognize one or more proteins and/or antigens from porcine reproductive and respiratory syndrome virus (PRRSV). The antibodies may be in a biological fluid of a PRRSV infected or at risk subject. The invention may be advantageously applied... Agent: Townsend And Townsend And Crew, LLP

20070212682 - Methods and apparatus for detection of viral infection: This invention generally relates to apparatus and methods for high-throughput, reproducible and inexpensive detection of virus infection using multiplexing technologies such as slide-based, microtiter plate-based and membrane-based microarrays and beads technologies. The apparatus and methods allow simultaneous detection of multiple viral infections in a plurality of test samples.... Agent: Michael Ye Andrews Kurth

20070212728 - 32263, a novel human biotin enzyme and uses thereof: The invention provides isolated nucleic acids molecules, designated BRE nucleic acid molecules, which encode novel biotin enzyme-related molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BRE nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which... Agent: Millennium Pharmaceuticals, Inc.

20070212718 - Apparatus and methods for applications of genomic microarrays in screening, surveillance and diagnostics: This disclosure describes combinations of apparatus and methods to comprise a system for broad use and effective application of analytical genomic microarrays for screening and surveillance. The methodology abandons reliance on typical volumes of peripheral blood samples obtained by phlebotomy, in preference for protocols enabling collection, stabilization, archives extraction and... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070212715 - Bacteria detection device, bacteria detection method and bacteria detection kit: The present invention provides a bacteria detection device, bacteria detection method and bacteria detection kit enabling rapid and accurate determination of bacteria present in a test sample, and particularly spore-forming, aerobic bacteria, with a simple procedure. The bacteria detection device according to the present invention is a microarray type of... Agent: Drinker Biddle & Reath (dc)

20070212707 - Cell cycle markers: The present invention relates to nucleic acid reporter constructs and host cells transfected with said constructs. The invention also relates to methods which are useful for determining the cell cycle status of a mammalian cell and for determining the effect of a test agent on the cell cycle position of... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070212725 - Cleavage of nucleic acids: The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe. The invention also includes the steps of... Agent: Agilent Techologies Inc

20070212710 - Competitive hybridization of dna probes and method of using the same: Methods are presented, in accordance for the present invention, for determining the length of a target probe. The methods have the steps of designing a first hybridization probe having a nucleic acid sequence, a portion of which overlaps with the nucleic acid sequence of a second hybridization probe, designing a... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070212704 - Compositions, methods, and kits for amplifying nucleic acids: The present teachings are directed to compositions, methods, and kits for amplifying target nucleic acids while reducing non-specific fluorescence and undesired amplification products, sometimes referred to as secondary amplification products or spurious side-products. The enzyme inhibitors disclosed herein comprise a nucleotide sequence and at least one quencher. Complexes comprising an... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070212695 - Compositions, methods, and kits for selective amplification of nucleic acids: The current teachings are directed to compositions, methods, and kits for selectively amplifying and for detecting target sequences. In some embodiments, a circularizable probe and/or a probe pair are disclosed for selectively amplifying target sequences. Methods for selectively amplifying target sequences are also disclosed, as are methods for detecting selectively... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070212691 - Cytolethal distending toxins and detection of campylobacter bacteria using the same as a target: The present inventors succeeded in cloning the CDT genes of C. coli and C. fetus, which were previously unknown, and in determining their sequences. In addition, the inventors also developed specific primers and primers common to the two species by comparing the CDTs of C. jejuni and C. fetus. Furthermore,... Agent: Bozicevic, Field & Francis LLP

20070212693 - Factor reca from bacillus licheniformis and reca-inactivated safety stems used for biotechnological production: The invention relates to the factor RecA from bacillus licheniformis DSM 13 (SEQ ID NO: 2), along with the associated gene recA (SEQ ID NO: 1), including related proteins and genes thereof, such as the variant indicated under SEQ ID NOS: 31 and 32, among others. According to the invention,... Agent: Connolly Bove Lodge & Hutz, LLP

20070212690 - Folate antagonists having improved selectivity: The present invention provides methods for identifying improved folate antagonists. The improved folate antagonists identified by the methods of the invention have increased selectivity. The increased selectivity of the folate antagonists results in a reduced risk of adverse effects following treatment with the improved folate antagonists. The improved folate antagonists... Agent: Alston & Bird LLP

20070212692 - Generation of recombinant genes in prokaryotic cells by using two extrachromosomal elements: The present invention relates in general to methods for generating and detecting recombinant DNA sequences in prokaryotic cells, in particular bacteria, by using two different extrachromosomal elements, in particular Saccharomyces cerevisiae and plasmids that can be used for conducting the inventive methods. DNA sequences for which these methods are relevant... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B475

20070212719 - Graphical rule based modeling of biochemical networks: Formalized graphical reaction rules and conventions accounting for chemical states and binding or reaction states are provided for modeling complex biological systems such as signal transduction pathways. A system model is derived by defining typed attributed graphs which delimit molecular entities and their possible states. Graph transformation rules defining a... Agent: John P. O'banion O'banion & Ritchey LLP

20070212723 - Human sodium channel isoforms: The present invention relates to novel isoforms in or near the 5′ untranslated region (upstream of the start codon) and the 3′ untranslated region (down stream of the start codon) which correlates with an increased risk of heart disease. These isoforms are various spliced variants of the wild-type sodium channel... Agent: Blank Rome LLP

20070212697 - Labeled nucleotide composition: Embodiments of labeled nucleotide compositions are described. Methods are described in which a sample containing RNA is contacted with an enzyme having an RNA ligation activity in the presence of a labeled nucleotide composition to provide labeled RNA. Methods of performing an array analysis of a labeled RNA sample are... Agent: Agilent Technologies Inc.

20070212688 - Method for distinguishing cbf-positive aml subtypes from cbf-negative aml subtypes: Disclosed is a method for distinguishing CBF-positive AML subtypes from CBF-negative AML subtypes in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.... Agent: Roche Molecular Systems Inc Patent Law Department

20070212687 - Method for distinguishing mll-ptd-positive aml from other aml subtypes: Disclosed is a method for distinguishing MLL-PTD-positive AML from other AML subtypes in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.... Agent: Roche Molecular Systems Inc Patent Law Department

20070212717 - Method for inhibiting hepatitis c virus replication: The present invention provides a method for modulating the replication of hepatitis C virus in a cell, comprising modulating the function of a phosphatidylinositol-4-kinase in the cell. In another aspect, the present invention provides a method for identifying a modulator of the replication of a hepatitis C virus, comprising: a)... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20070212708 - Method for the production of a solution, associated arrangement and uses of the method and arrangement: Solid matter in a cavity is used to produce a solution of at least one solid matter in a solvent. The solid matter which is soluble in the solvent in initially covered and/or surrounded in the cavity by a medium which is insoluble in a solvent, such that dissolving of... Agent: Harness, Dickey & Pierce, P.L.C

20070212726 - Methods for detection of a target nucleic acid: The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe. The invention also includes the steps of... Agent: Agilent Techologies Inc

20070212701 - Methods for diagnosing and treating ischemia and reperfusion injury and compositions thereof: The present invention is directed to the identification of novel targets for therapeutic intervention and prevention of ischemia and reperfusion injury resulting from hypoxia, stroke, heart attack, chronic kidney failure or organ transplantation. In particular, the present invention is directed to the identification of novel targets for the prevention of... Agent: Fitzpatrick Cella Harper & Scinto

20070212685 - Methods for identifying analgesic agents: The present invention relates to the discovery that mutations in SCN9A are causative of Congenital Indifference to Pain (CIP) in humans. The invention also relates to methods of utilizing the SCN9A gene and expression products thereof for the screening and identification of therapeutic agents, including small organic compounds, which are... Agent: Alan J. Grant, Esq. C/o Carella, Byrne, Bain, Gilfillan,

20070212712 - Methods for identifying modulators of hedgehog autoprocessing: The present invention relates to methods of screening for modulators of Hedgehog peptide autoprocessing with methods that are useful in both in vivo and high-throughput in vitro systems. The present invention also relates to reagents identified by the methods of the present invention for use in the modulation of Hh... Agent: Kevin M. Farrell Pierce Atwood

20070212721 - Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor: Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of biomarkers in a body sample, wherein overexpression of the biomarkers is indicative of an increased likelihood of having ovarian cancer. The screening methods... Agent: Alston & Bird LLP

20070212722 - Methods of detecting a target nucleic acid: The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe. The invention also includes the steps of... Agent: Agilent Techologies Inc

20070212724 - Methods of detecting a target nucleic acid: The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe. The invention also includes the steps of... Agent: Agilent Techologies Inc

20070212709 - Methods of labeling nucleic acids with energy transfer dyes: Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor... Agent: Dechert LLP

20070212700 - Methods of using and analyzing biological sequence data: Methods of using biological sequence data. Evolved biological sequences may be used to identify the defining biological characteristics of the sequences—the three-dimensional structure and biochemical function. Some of the present methods extract such information, use such information to predict functional mechanism, and/or use such information in the design of artificial... Agent: Fulbright & Jaworski L.L.P.

20070212727 - Microorganisms for therapy: Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also... Agent: Fish & Richardson, PC

20070212716 - Nezara viridula ecdysone receptor: Provided are protein and coding sequences for the ecdysone receptor polypeptide isoforms and ultraspiracle polypeptide from Nezara viridula and methods of employing them.... Agent: Greenlee Winner And Sullivan P C

20070212720 - Non-invasive method for diagnosing fetal cells and cancer cells: A non-invasive method for determining the developmental age of a fetus or detecting cancer cells in a sample is provided. The method utilizes, for example, a sample of blood from a pregnant female and telomeric nucleic acid probes.... Agent: Kelley Drye & Warren LLP

20070212706 - Novel alkaline proteases and detergents and cleaners comprising these novel alkaline proteases: The present application relates to two novel alkaline proteases (SEQ ID NO. 4 and 7) which are similar to one another, whose DNA was obtained from soil samples, and C-terminally deleted, likewise proteolytically active fragments thereof (SEQ ID NO. 5 and 8), all alkaline proteases similar at least to 90%... Agent: Paul & Paul

20070212714 - Novel genes tzap7/a, tzap7/b and tzap7 involved in t cell activation and uses thereof: Described are generally immune response cDNA TZap7/A, TZap7/B and TZap7 polynucleotides encoding novel proteins involved in modulation of immune responses and antibodies recognizing said proteins. Furthermore, vectors comprising the aforementioned polynucleotides and host cells transformed therewith as well as their use in the production of the above-defined proteins are described.... Agent: Cooper & Dunham, LLP

20070212698 - Operator independent programmable sample preparation and analysis system: The present invention provides a protocol and apparatus for enriching circulating tumor cells and other rare cells from blood, including debris and other components, from samples with high precision and at high throughput rates. This invention discloses an improved processing system from previously described semi-automated sample processing. The system further... Agent: Immunicon Corporation

20070212711 - P1-34 expression units: The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered... Agent: Lahive & Cockfield, LLP

20070212713 - Polymorphisms in growth hormone receptor, ghrelin, leptin, neuropeptide y, and uncoupling protein 2 genes and their associations with measures of performance and carcass merit in beef cattle: The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention relates to the identification of a single nucleotide polymorphisms (SNPs) within the... Agent: Frommer Lawrence & Haug

20070212694 - Polymorphisms in the nod2/card15 gene: The present invention relates to methods as well as to nucleotide sequences used in these methods for prognosis and/or diagnosis of diseases associated with at least one of the polymorphisms Nod2-SNP8, Nod2-SNP12, Nod2-SNP13 in the NOD2/CARD15 gene.... Agent: J C Patents Inc

20070212689 - Prenatal diagnosis using cell-free fetal dna in amniotic fluid: The present invention relates to improved methods of prenatal diagnosis, screening, monitoring and/or testing. The inventive methods include the analysis by array-based hybridization of cell-free fetal DNA isolated from amniotic fluid. In addition to allowing the prenatal diagnosis of a variety of diseases and conditions, and the assessment of fetal... Agent: Choate, Hall & Stewart LLP

20070212699 - Process for high throughput dna methylation analysis: There is disclosed an improved high-throughput and quantitative process for determining methylation patterns in genomic DNA samples based on amplifying modified nucleic acid, and detecting methylated nucleic acid based on amplification-dependent displacement of specifically annealed hybridization probes. Specifically, the inventive process provides for treating genomic DNA samples with sodium bisulfite... Agent: Davis Wright Tremaine, LLP

20070212703 - Proteinaceous pharmaceuticals and uses thereof: The present invention provides cysteine-containing scaffolds and/or proteins, expression vectors, host cell and display systems harboring and/or expressing such cysteine-containing products. The present invention also provides methods of designing libraries of such products, methods of screening such libraries to yield entities exhibiting binding specificities towards a taraget molecule. Further provided... Agent: Wilson Sonsini Goodrich & Rosati

20070212705 - Pseudomonas aeruginosa l-d carboxypeptidase a, expression and activity: The present invention provides nucleic acid and polypeptide sequences of a L, D carboxypeptidase from Pseudomonas aeruginosa (PA LDC). The isolated nucleic acid or polypeptide molecules of the invention can be used in detection assays screening and drug discovery assays.... Agent: Philip S. Johnson Johnson & Johnson

20070212702 - Recurrent gene fusions in prostate cancer: Recurrent gene fusions of androgen regulated genes and ETS family member genes in prostate cancer are described. Compositions and methods having utility in prostate cancer diagnosis, research, and therapy are also provided.... Agent: Medlen & Carroll, LLP

20070212696 - Self-quenching homofluorophore compositions for detecting enzyme activity: The inventive subject matter relates to methods, kits, and compositions for detecting enzyme activity in a biological sample. In particular, the inventive subject matter relates to methods, kits, and compositions for detecting von Willebrand factor degrading enzyme activity in a biological sample.... Agent: Nath & Associates, PLLC

20070212686 - Use of t-cadherin as a target: This invention relates to the use of T-cadherin polypeptides for screening for modulators thereof, and to the use of said modulators for treating disorders selected from the group consisting of a metabolic disorder, a gynecologic disorder, a chronic inflammatory disorder and a liver or renal disorder. Metabolic disorders that may... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070212730 - Covalently immobilized protein gradients in three-dimensional porous scaffolds: The invention provides a method for forming an immobilized agent gradient within a 3-dimensional porous scaffold. A 3-dimensional scaffold formed from a biocompatible material is provided. The surface of the scaffold and/ or the agent is activated so as to allow binding of the agent to the scaffold. The activated... Agent: David S. Resnick

20070212729 - Prognostic methods for congestive heart failure: Provided are methods for predicting survival outcome of an individual suffering from congestive heart failure. In accordance with the method, a patient's survival outcome is determined by taking into consideration the levels of two markers in combination, the combination being more predictive of survival than either marker alone. The markers... Agent: Foley & Lardner LLP

20070212731 - Solid support having ligand immobilized thereon by using photocleavable linker: The present invention provides a method of analyzing the interaction between a ligand and a target molecule, which uses a solid support wherein the ligand is immobilized via a linker cleavable by photoirradiation, particularly a method of searching and purifying a target molecule. By intervening a linker specifically cleavable by... Agent: Leydig Voit & Mayer, Ltd

20070212732 - Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations: Enriched pancreatic stem and progenitor cell populations, and methods for identifying, isolating and enriching for pancreatic stem cells using reagents that bind to cell surface markers are provided.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070212733 - Methods and compositions related to b cell assays: The present invention relates to novel methods for treating diseases and monitoring B cell levels in subjects and kit and compositions relating thereto by measuring serum BAFF levels in the subjects.... Agent: Clark & Elbing LLP

20070212738 - Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors: The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an EGFR kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an EGFR kinase inhibitor, comprising assessing whether the tumor cell has undergone an... Agent: Osi Pharmaceuticals, Inc.

20070212735 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Genentech, Inc.

20070212736 - Functional immunohistochemical cell cycle analysis as a prognostic indicator for cancer: The present invention relates to a method of determining the presence of a retinoblastoma protein (Rb)-mediated cancerous or pre-cancerous condition in a sample of fixed cells that involves exposing the sample to an antibody that recognizes phosphorylation of serine on the retinoblastoma protein (pS-Rb), and identifying cells in the sample... Agent: Nixon Peabody LLP - Patent Group

20070212737 - Isolation and use of solid tumor stem cells: A small percentage of cells within an established tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give... Agent: Medlen & Carroll, LLP

20070212734 - Method for distinguishing t(11q23)/mll-positive leukemias from t(11q23)/mll negative leukemia: Disclosed is a method for distinguishing t(11q23)/MLL-positive leukemias from t(11q23)/MLL negative leukemias in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.... Agent: Roche Molecular Systems Inc Patent Law Department

20070212739 - Novel cancer-associated antigens and methods of their identification and use: The present invention provides novel, isolated, tumor-associated antigens, and methods for identifying such antigens in a biological sample, and of screening for the presence of such an antigen in a biological specimen, wherein the tumor antigen identified reacts with serum from a subject treated with a vaccine comprising a cytokine... Agent: Dla Piper US LLP

20070212740 - Detection of tuberculosis and infection by mycobacterium tuberculosis using hbha: The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a... Agent: Birch Stewart Kolasch & Birch

20070212742 - Determination of a midregional proadrenomedullin partial peptide in biological fluids for diagnostic purposes, and immunoassays for carrying out such a determination: Method for the determination of adrenomedullin immunoreactivity in biological fluids for diagnostic purposes, in particular in sepsis, cardiac and cancer diagnosis, in which the midregional partial peptide (mid-proAM; SEQ ID NO:3) of proadrenomedullin, which comprises the amino acids (45-92) of the complete preproadrenomedullin (pre-proAM; SEQ ID NO:1), is measured in... Agent: Heslin Rothenberg Farley & Mesiti PC

20070212743 - Assays for determining anticoagulant cofactor activity: Methods are disclosed for determining, in a sample derived from a human, the functional activity of a component of the human blood coagulation system, which activity can be correlated to conversion of a substrate specific for activated Protein C (APC), by measuring in an assay medium containing the sample and... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP (formerly Kirkpatrick & Lockhart Nicholson Graham)

20070212744 - Device for analyzing the coagulation or aggregation behavior of blood: A device is provided for analyzing the coagulation and/or behavior of blood. The blood flows through an opening (9) that is disposed in a porous part (5) while a substance which influences blood aggregation can be delivered to the blood. A preliminary diffuser chamber (3) from which blood flows to... Agent: Milde & Hoffberg, LLP

20070212747 - Cassette containing growth medium: The invention features devices for capturing and culturing cells (e.g., microorganisms, cells containing microorganisms, or cells from eukaryotic cell cultures) and methods of using these devices. One device is a cassette containing growth media that may be employed in an automated rapid enumeration system. The cassette has, for example, been... Agent: Clark & Elbing LLP

20070212748 - Detection of microbiological growth in a sealed container using a poising agent: According to the present invention, there is disclosed a method of stabilizing the output signal of a system that detects microbiological growth in a sealed sample container that contains a sample which may contain an unknown microorganism. One embodiment relates to a method of providing a sealed sample container which... Agent: Howard M Cohn Patent Attorney LLC

20070212749 - Detection of microbiological growth in a sealed container using a poising agent: According to the present invention, there is disclosed a method of stabilizing the output signal of a system that detects microbiological growth in a sealed sample container that contains a sample which may contain an unknown microorganism. One embodiment relates to a method of providing a sealed sample container which... Agent: Howard M Cohn Patent Attorney LLC

20070212750 - Microbiological test device, test and incubation systems including it, and method using it: The device includes a first body including an inlet orifice, an outlet orifice (21), a filter membrane (3), a support member (4) for the membrane (3) that is removable from said first body (2) and a second body (6) removably fixed to said first body (2); the outlet orifice (21)... Agent: Nields & Lemack

20070212751 - Microbial method for the 11beta hydroxylation of 9beta, 10alpha-steriods: Use of bacterial strains of the species Amycolatopsis mediterranei for microbial transformation of 9β,10α-steroids of formula (I) to their corresponding 11β-hydroxyl analogues, as well as specific strains of that species, a process for transforming 9β,10α-steroids to their corresponding 11β-hydroxyl derivatives using bacterials strains of the species Amycolatopsis mediterranei, and subsequent... Agent: Crowell & Moring LLP Intellectual Property Group

20070212752 - Cell-free protein synthesis for controlling introduction of modification group into protein: It is intended to provide a method capable of introducing an arbitrary modification group into a synthetic protein and a method capable of easily controlling the syntheses of a modified protein and an unmodified protein. The present invention provides a method of cell-free protein synthesis comprising: performing cell-free protein synthesis... Agent: Sughrue Mion, PLLC

20070212753 - Altered antibodies and their preparation: An altered antibody chain is produced in which the CDR's of the variable domain of the chain are derived from a first mammalian species. The framework-encoding regions of DNA encoding the variable domain of the first species are mutated so that the mutated framework-encoding regions encode a framework derived from... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070212754 - Hepatitis c virus ns2/3 activity assay: The invention provides a novel assay for NS2/3 cleavage detection, particularly, a novel assay for the detection of the NS3 cleavage product in the presence of uncleaved NS2/3 based on discrimination of the activity of the resulting NS3 protease product from the NS3 protease activity of the NS2/3 uncleaved protein.... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20070212756 - Methods for treating lentivirus infections: The present invention provides methods of identifying an agent that inhibits an activity of a lentiviral Vif protein. The present invention provides methods of identifying an agent that increases the level of active APOBEC3G in a cell. The present invention provides agents identified by a subject screening method; and further... Agent: Townsend And Townsend And Crew, LLP

20070212755 - Novel sequence for improving expression of nucleic acid: The invention provides a novel anti-repressor element, which is useful for improving expression of nucleic acid in host cells. Methods using the novel anti-repressor element for producing a protein of interest are also provided. The invention also provides new configurations of expression cassettes comprising anti-repressor elements.... Agent: Trask Britt

20070212757 - Expression system for the b subunit of cholera toxin: The present invention provides an expression system for producing a B subunit of a cholera toxin (CTB) wherein the expression system comprises a Vibrio cholerae host cell lacking the functionality of a thyA gene; and an expression vector comprising a functional thyA gene and a CTB gene which is substantially... Agent: Bacon & Thomas, PLLC

20070212758 - Methods for the production of 3-o-deactivated-4'-monophosphoryl lipid a (3d-mla): Herein is disclosed a method for producing lipopolysaccharide (LPS), comprising: (a) growing a culture of deep rough mutant bacterial strain in a medium; (b) maintaining the culture in stationary phase for at least about 5 hr; (c) harvesting cells from the culture; and (d) extracting LPS from the cells. The... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B475

20070212759 - Production of 2'-deoxynucleosides and 2'-deoxynucleoside precursors from 2-dehydro-3-deoxy-d-gluconate: This invention relates to a process for preparing 2′-deoxynucleoside compounds or 2′-deoxynucleoside precursors using 2-dehydro-3-deoxy-D-gluconic acid (usually abbreviated as KDG) or its salts as a starting material. A variety of 2′-deoxynucleosides and their analogues are used as a starting material for synthesis or drug formulation in production of an antiviral,... Agent: Jean Louis Seugnet Rhodia Inc Cn 7500

20070212760 - Methods for dna amplification and sequencing: The osmoprotectants proline, 2-methyl-4-carboxy-3,4,5,6-tetrahydropyrimidine (“THP(B)”, and 2-methyl-4-carboxy-5-hydroxy-3,4,5,6,-tetrahydropyrimidine (“THP(A)”) are capable of increasing the thermal stability of DNA polymerases at elevated temperatures. THP(B) is further effective in lowering the melting temperature of double-stranded DNA. Proline, THP(A) and THP(B) are thus useful in procedures involving melting of double-stranded DNA and/or polymerase-mediated DNA... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070212761 - Methods of detecting a target nucleic acid: The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe. The invention also includes the steps of... Agent: Agilent Techologies Inc

20070212762 - Vectors for directional cloning: The invention provides vectors and methods for directional cloning.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20070212763 - Process for producing pentose-5-phosphate ester: A pentose such as ribose, arabinose, 2-deoxyribose, 1-methoxy-2-deoxyribose or the like is reacted with a phosphoric acid donor such as a pyrophosphoric acid or an alkali metal salt thereof in the presence of an acid phosphatase. Thus, a pentose-5-phosphate ester can be produced, such as a ribose-5-phosphate ester, an arabinose-5-phosphate... Agent: Buchanan, Ingersoll & Rooney PC

20070212764 - Method for producing l-amino acids using bacterium of the enterobacteriaceae family: There is disclosed a method for producing an L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine, L-tryptophan, or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of N-acetylglucosamine permease encoded by the nagE gene.... Agent: Cermak & Kenealy LLP Acs LLC

20070212765 - Method for preparing an organic amine: The invention relates to a method for preparing a complex of an organic amine and lactic acid in a reactor, characterized in that a water-miscible organic amine is brought into contact with magnesium lactate in an aqueous medium in the reactor to form the complex and precipitated magnesium hydroxide, after... Agent: Oliff & Berridge, PLC

20070212766 - Method for the enzymatic production of chiral alcohols: e

20070212767 - Generation and isolation of antigen-specific t cells: The present invention relates generally to methods for generating, expanding, and isolating antigen-specific T cells. Compositions of antigen-specific T cells activated and expanded by the methods herein are further provided.... Agent: Invitrogen Corporation C/o Intellevate

20070212768 - Alpha-amylase variants stabilized against dimerization and/or multimerization, method for the production thereof, and detergents and cleansers containing these alpha-amylase variants: The present invention relates to α-amylase variants that are stabilized to dimerization and/or multimerization, in particular at elevated temperatures or high pH, by point mutagenesis of positively polarized or charged or neutral surface amino acids to give more negatively polarized or charged amino acids. The invention further relates to methods... Agent: Paul & Paul

20070212769 - Synthetic mammalian alpha-n-acetylglucosaminidase and genetic sequences encoding same: The present invention relates generally to mammalian α-N-acetyglucosaminidase and to genetic sequences encoding same and to their use in the investigation, diagnosis and treatment of subjects suspected of or suffering from α-N-acetyglucosaminidase deficiency.... Agent: Dilworth & Barrese, LLP

20070212770 - Oligopeptide-free cell culture media: The present invention relates to oligopeptide-free cell culture media comprising at least 0.5 mg/L of a polyamine and to methods for cultivating cells in said oligopeptide-free cell culture media comprising at least 0.5 mg/L of a polyamine. The invention also relates to methods for expressing at least one protein in... Agent: Baxter Healthcare Corporation

20070212771 - Method for preparation of a suspension of microorganisms: The invention relates to a method for preparation of a suspension of micro-organisms method for preparation of a suspension of micro-organisms in a liquid, characterised in using a sealed reservoir (1) comprising:—2 chambers communicating by means of the lower section of the reservoir, at least one inlet opening (2), for... Agent: Frost Brown Todd, LLC

20070212772 - Rhizobium leguminosarum strain and use thereof as plant inoculant: A novel strain of Rhizobium leguminosarum designated S012A-2 (IDAC 080305-01). The strain is useful for improving plant growth and yield of legumes, particularly peas and lentils by nitrogen fixation. The strain is contacted with legume seeds prior to and/or during germination and growth, and may be used to form an... Agent: Kirby Eades Gale Baker

20070212773 - Electrical signal measuring device for cells in culture and electrical signal measuring method that uses same device: An electrical signal measuring device that can measure electrical characteristics of cells in culture in real time and with high accuracy while maintaining them in a favorable state and an electrical signal measuring method that uses the device are disclosed. The electrical signal measuring device 1 for cells in culture... Agent: Kenyon & Kenyon LLP

20070212774 - Thermocycler with a temperature control block driven in cycles: A thermocycler comprising a temperature control block (1,2,3) which is designed to receive several specimens and which is fitted with a control unit (6) that in consecutive cycles applies the different temperature levels (40° C., 70° C., 95° C.) of a PCR procedure to said block, said thermocycler being characterized... Agent: Rankin, Hill, Porter & Clark LLP

20070212775 - Microtiter plate, method of manufacturing thereof and kit: The invention relates to a vessel and kit for thermal cycling applications, a method for manufacturing such a vessel. The vessel comprises, in the form of a planar grid having a predefined pitch, a plurality of sample wells each having a well wall, which defines an open well end and... Agent: Birch Stewart Kolasch & Birch

20070212776 - Apparatus for recycling of protein waste and fuel production: The apparatus of the present invention is useful for recycling protein waste and producing fuel from protein waste. Waste is ground by a grinding means and digested by a enzyme digest medium composed of enzymes, preservatives, and inedible egg. The ground proteins are digested with the enzyme in recirculated digest... Agent: G. Brian Pingel, Brown, Winick, Graves, Gross, Baskerville And Schoenebaum, P.L.C

20070212777 - Undifferentiated stem cell culture systems: The present application discloses methods expanding SCs in an undifferentiated state, the methods comprising incubating undifferentiated SCs in suspension within a culture system comprising basic medium and knockout serum replacement (KOSR). The methods may also be applicable for selective spontaneous or directed differentiation of SCs into a selected population of... Agent: The Nath Law Group

20070212778 - Cell culture medium: We describe a method of growing an animal cell in a culture medium, in which the culture medium comprises an elevated concentration of a thymidine family member, in which the growth or viability of the animal cell is increased as a result of the elevated concentration of the thymidine family... Agent: Foley And Lardner LLP Suite 500

20070212779 - Targeting adenoviral vectors to dendritic cells: The present invention provides DC-SIGN-targeted recombinant adenoviral vectors and methods of using these vectors to transduce immature dendritic cells. More specifically, these vectors employ a two-component targeting moiety which may contain an adenoviral fiber protein that may comprise an immunoglobulin-binding domain and an anti-DC-SIGN antibody as a targeting ligand.... Agent: Frommer Lawrence & Haug

20070212780 - Intron double stranded rna constructs and uses thereof: The present invention is in the field of plant genetics and provides agents capable of gene-specific silencing. The present invention specifically provides double-stranded RNA (dsRNA) agents, methods for utilizing such agents and plants containing such agents.... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20070212781 - Method for obtaining new life forms: The present invention relates to a method for generating a novel form of life comprising the steps consisting of: a) irreversible alteration of the genome of a microbial clone; b) cultivation of a vast population of microbial cells originating from the altered clone obtained in step a) during numerous generations... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070212782 - High density growth of t7 expression strains with auto-induction option: A method for promoting auto-induction of transcription of cloned DNA in cultures of bacterial cells grown batchwise is disclosed. The transcription is under the control of a promoter whose activity can be induced by an exogenous inducer whose ability to induce said promoter is dependent on the metabolic state of... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory

20070212783 - Fast method of transforming competent cells: m

20070207468 - 12 kb sequence immediately adjacent to and upstream of the akt1 gene locus containing multiple genetic variations associated with changes in metabolic syndrome, and methods of use: We have identified a 12 kb sequence immediately upstream of the AKT1 gene locus in humans that contains single nucleotide polymorphic polynucleotide (SNPs) whose alleles in strong linkage disequilibrium, and that are prognostic for metabolic syndrome and its metabolic sequellae such as hyperglycemia and type 2 diabetes. The +G205T allele... Agent: Dr. Melvin Blecher

20070207486 - Angiogenesis pathway gene polymorphisms for therapy selection: A method for determining whether a patient in need thereof will respond to anti-VEGF antibody based chemotherapy by screening a suitable cell or tissue sample isolated from the patient for at least one genomic polymorphism or genotype selected from (i) IL-8(−251); (ii) VEGF(936); or (iii) AM (3′ CA repeats), wherein... Agent: Foley & Lardner LLP

20070207485 - Automated contamination-free seed sampler and methods of sampling, testing and bulking seeds: In various embodiments, the present disclosure provides an automated seed sampler system that includes a milling station for removing at least a portion of seed coat material from a seed and a sampling station for extracting a sample of seed material from the seed where the seed coat has been... Agent: Harness, Dickey & Pierce, P.L.C

20070207469 - Reactive mixture with growing molecular species: This invention relates to a method for preparing and dispensing a reactive mixture including at least a growing molecular species formed by mixing multiple reactive components in a pressure dispenser with the features of precise ratio, complete mixing, impact-activation, safeguard, and self-contained package.... Agent: Liang Wang

20070207501 - Evaluation of the performance profile of catalysts: A searchable library of catalysts, wherein each catalyst is defined by a specific performance profile, is created by a series of steps. The first involves the selection of a catalyst, a substrate and at least two different chemical reactions for catalyst characterization. The next involves contacting the catalyst and substrate... Agent: Venable LLP

20070207504 - Proteomic methods for the identification of differentiated adipose cells and adipose derived adult stem cells: The present invention includes method for identifying, differentiating and distinguishing undifferentiated adipose-derived adult stem cells and differentiated adipose-derived adult stem cells using the proteomic profile of an adipose cell.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070207513 - Methods, products, and kits for identifying an analyte in a sample: Methods, products, and kits for identifying an analyte in a sample are provided. One embodiment of a method for identifying an analyte in a sample includes combining the sample with a first reactant capable of specifically coupling to the analyte. The first reactant is coupled to beads. The method also... Agent: Daffer Mcdaniel LLP

20070207516 - Cholesterol measurement system and method: A cholesterol testing system and method are provided in which cholesterol values determined from testing a sample are analyzed and normalized to generate a set of cholesterol values.... Agent: Dla Piper Rudnick Gray Cary Us, LLP

20070207450 - System and method for process automation: Disclosed are systems and methods for manipulating chemical, biological, and/or biochemical samples, optionally supported on substrates and/or within chambers, for example biological samples contained on chips, within biological chambers, etc. In certain embodiments, an apparatus configured to be able to position a chamber or other substrate in one or more... Agent: Wolf Greenfield & Sacks, P.C.

20070207452 - Method of detecting micronucleus in cell: The present invention provides a method of detecting a micronucleus in a living cell to be measured, without having to fixate the cell, characterized by comprising generating a mother cell by introducing a gene encoding a single or a plurality of nucleus-related proteins and a gene encoding a fluorescence protein... Agent: Scully Scott Murphy & Presser, PC

20070207451 - Methods for automatically identifying microorganisms collected on a carrier: For automatic identification of microorganisms collected on a carrier, a color image of the carrier surface with collected microorganisms is recorded and digitalized. The digitalized image is converted into a grayscale image and optionally converted subsequently into a silhouette image. When microorganisms are present, an image is produced with full-surface... Agent: Gudrun E. Huckett Draudt

20070207455 - Compositions and methods for detecting an hcv-1 subtype: The present invention provides methods and compositions for detecting hepatitis C virus (HCV). In particular, the present invention provides nucleic acid detection assays configured to detect a novel sub-type of HCV-1.... Agent: Medlen & Carroll, LLP Suite 350

20070207453 - Multiplex pcr assay: This invention relates to a multiplex PCR assay capable of screening or detecting the relevant microbial organism specific to Cytomegalo virus (CMV), Herpes Simplex virus (HSV) and Varicella zoster virus (VZV) present in a sample, comprising a reaction mixture of a combination of three sets of primers, one of said... Agent: Venable LLP

20070207456 - Multiplexed assay and probes for identification of hpv types: A DNA microarray, preferably in the form of a chip, contains probes which hybridize to generate primers capable of amplifying approximately 89 HPV types. These target the E1 region of the gene. The design of the chip allows for the detection of any known HPV type, based on a unique... Agent: Peters Verny , L.L.P.

20070207454 - Novel method to identify targets for antibiotic development: The present invention identifies a new approach for antibiotic development. By identifying molecules in the cell wall of bacteria responsible for binding bacteriophage lytic enzymes, the present invention focuses on the pathways for possible antibiotic development. The pathway for the bacterial molecule is critical for bacterial survival and thus serves... Agent: Darby & Darby P.C.

20070207458 - primer for detecting alicyclobacillus: Primers specific for an Alicyclobacillus spp. are used to amplify specific regions of 16S rDNA gene of the Alicyclobacillus spp., and the presence or absence of the amplified product is confirmed to detect the Alicyclobacillus spp. (especially Alicyclobacillus acidoterrestris).... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070207479 - Biomarkers for oral tongue cancer metastasis and extracapsular spread (ecs): The present invention provides for the first time molecular diagnostic and prognostic markers for tongue cancer metastasis and extracapsular spread that are independent of histopathological evaluation.... Agent: Townsend And Townsend And Crew, LLP

20070207478 - Biomarkers for prostate cancer metastasis: The present invention provides genomic markers for determining the predisposition of prostate cancer to become metastasized.... Agent: Townsend And Townsend And Crew, LLP

20070207483 - Buffers for detection of mrna separated in a microfluidic device: The present invention provides methods and kits using low conductivity buffers for the detection of mRNA from a cell lysate separated in a microfluidic device. The buffers do not affect the integrity of the cell nucleus, thereby allowing for generation of a cell lysate that can be directly used as... Agent: Townsend And Townsend And Crew, LLP

20070207465 - Compositions for the electronic detection of analytes utilizing monolayers: The present invention relates to the use of self-assembled monolayers with mixtures of conductive oligomers and insulators to detect target analytes.... Agent: Morgan, Lewis & Bockius, LLP

20070207492 - Computational methods and systems to adjust a humoral immune response: The present application relates, in general, to a system and/or method related to detection and/or treatment.... Agent: Searete LLC Clarence T. Tegreene

20070207467 - Detection of lymph node metastasis from gastric carcinoma: Methods, compositions and articles are directed to diagnosing the lymph node metastasis from gastric carcinoma, differentiating between negative lymph nodes and lymph nodes with metastasis from gastric carcinoma, testing tissue samples of for determining gastric carcinoma staging status.... Agent: Philip S. Johnson Johnson & Johnson

20070207495 - Helicase-dependent amplification of nucleic acids: Methods and a kit are provided for selectively and exponentially amplifying nucleic acids and include the use of a helicase preparation and a DNA polymerase such that the amplification can be performed isothermally.... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20070207470 - Humanization of antibodies using a putative ancient binary genetic code: A method for converting non-human antibodies into “humanized” versions having increased safety and efficacy employs a putative ancient binary genetic code to derive new antibody structures. The method entails determining the amino acid sequence of variable regions of heavy and/or light chains of the non-human antibody, identifying the framework sequences... Agent: James H. Meadows And Medicus Associates

20070207473 - Hypertrophic cardiomyopathy: This document provides methods and materials related to identifying, assessing, and predicting hypertrophic cardiomyopathy (HCM) in mammals. For example, methods and materials for using mutations (e.g., mutations in ZASP and MYBPC3 nucleic acids) to identify, assess, and predict HCM in mammals (e.g., humans) are provided.... Agent: Fish & Richardson P.C.

20070207477 - Kits useful for sequencing nucleic acids: Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor... Agent: Dechert LLP

20070207463 - Method: A method for enriching the GC base pair content of a DNA molecule the method comprising the steps of (a) providing a DNA template molecule in which at least some of the A residues are base paired with U residues and (b) replicating the DNA template molecule provided in step... Agent: Hunton & Williams/new York Intellectual Property Dept.

20070207490 - Method and system for generating sample plate layout for validation: Systems and methods are provided that relate to a platform, techniques, and processes for verifying the precision, sensitivity, accuracy, reproducibility, and other characteristics of biological tests, such as DNA identification or other tests or assays. According to various embodiments, a logic engine can guide a user to arrange, conduct, and... Agent: Kilyk & Bowersox, P.l.l.c.

20070207472 - Method for detecting cytosine methylations: A method is described for the detection of 5-methylcytosine in genomic DNA samples. First, a genomic DNA from a DNA sample is chemically converted with a reagent, whereby 5-methylcytosine and cytosine react differently. Then the pretreated DNA is amplified with the use of a polymerase with primers of different sequence.... Agent: Kriegsman & Kriegsman

20070207494 - Method for detecting mutated polynucleotides within a large population of wild-type polynucleotides: Methods are provided for detecting a mutant polynucleotide in mixture of mutant polynucleotides, wild-type polynucleotides and unrelated polynucleotides. The method uses an extension primer complementary to a first target sequence in both the wild-type and mutant polynucleotides. The method also uses a probe complementary to a second target sequence in... Agent: Calfee Halter & Griswold, LLP

20070207464 - Method for diagnosing renal diseases or predispositions: The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a mutation in the UMOD supports a diagnosis of a disease or a predisposition to contract a disease... Agent: Leydig Voit & Mayer, Ltd

20070207459 - Method for distinguishing immunologically defined all subtype: Disclosed is a method for distinguishing immunologically defined ALL subtypes Pro-B-ALL, c-ALL, Pre-B-ALL, c-ALL/Pre-B-ALL, mature B-ALL, precursor B-ALL, Pro-T-ALL, Pre-T-ALL, cortical T-ALL, mature T-ALL, and/or T-ALL in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.... Agent: Roche Molecular Systems Inc Patent Law Department

20070207460 - Method for enriching and stabilising components which contain dna and which are made of biological materials: The invention relates to an improved method for the accumulation and stabilization of DNA-containing components from biological materials, especially from blood samples. The DNA-containing sample materials are partially lysed in a lysis-binding buffer system, and the DNA-containing components, such as cell nuclei, are bound to a functionalized solid surface. The... Agent: Cohen, Pontani, Lieberman & Pavane

20070207488 - Method for identifying altered vitamin d metabolism: A method is provided for identifying an individual as having altered vitamin D metabolism comprising analyzing a biological sample from the individual for the presence of CYP24 SNPs and/or aberrantly spliced CYP24 mRNA. The presence of the SNPs and/or the aberrantly spliced CYP24 mRNA indicates that the individual has altered... Agent: Hodgson Russ LLP The Guaranty Building

20070207466 - Method for non-invasive prenatal diagnosis: The present invention is directed to methods of detecting nucleic acids in a biological sample. The method is based on a novel combination of a base extension reaction, which provides excellent analytical specificity, and a mass spectrometric analysis, which provides excellent specificity. The method can be used, for example, for... Agent: Ronald I. Eisenstein Nixon Peabody, LLP

20070207475 - Method for producing polymers having a preselected activity: The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.... Agent: Howrey LLP

20070207476 - Methods and compositions for labeling nucleic acids: The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. In particular, the methods include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label. Such methods do not require fixation and... Agent: Choate, Hall & Stewart LLP

20070207457 - Methods for obtaining aptamers using microarray: A microarray originally developed for analyzing intracellular RNA expressions can be used to easily load polynucleotides onto a chip and to instantaneously determine polynucleotides (aptamers) capable of binding to a target molecule. Namely, the present inventors discovered that a microarray can be used to rapidly and efficiently obtain aptamers that... Agent: Peter G Carroll Medlen & Carroll

20070207487 - Photoelectrochemical synthesis of high density combinatorial polymer arrays: In a method for creating polymer arrays through photoelectrochemically modulated acid/base/radical generation for combinatorial synthesis, electrochemical synthesis is guided by a spatially modulated light source striking a semiconductor in an electrolyte solution. A substrate having at its surface at least one photoelectrode that is proximate to at least one molecule... Agent: Norma E Henderson Henderson Patent Law

20070207484 - Polyol-modified silanes as precursors for silica: The invention relates to the preparation of monolithic silica under mild conditions from alkoxysilanes derived from sugars, sugar acids, sugar alcohols and polysaccharides including glycerol, sorbitol, mannose and dextran. Unlike the commonly used silica starting material TEOS (Si(OEt)4), the sol-gel hydrolysis and cure of the sugar derivatives are not very... Agent: Bereskin And Parr

20070207493 - Positively charged membrane: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a... Agent: Leydig Voit & Mayer, Ltd

20070207462 - Preventive/remedy for respiratory diseases: It is intended to provide a compound inhibiting the activity of a protein having an amino acid sequence which is the same or substantially the same as one of the amino acid sequences represented by SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24,... Agent: Edwards Angell Palmer & Dodge LLP

20070207474 - Promoter polymorphisms of the blys gene and use in diagnostic methods: The present invention provides an isolated polynucleotide comprising at least one polymorphic nucleotide sequence, for example, at position −871 from the promoter region of the BLyS gene, and diagnostic assays for detecting the presence of this polymorphism associated with a condition associated with BLyS activity, such as hematological malignancy including... Agent: Zymogenetics, Inc. Intellectual Property Department

20070207480 - Protein profile for osteoarthritis: The present invention relates to the identification and use of protein expression profiles with clinical relevance to osteoarthritis (OA). In particular, the invention provides the identity of marker proteins whose expressions are correlated with OA, OA subtype, and/or OA progression. Methods and kits are described for using these protein expression... Agent: Choate, Hall & Stewart LLP

20070207489 - Reagents and methods for cancer prognosis and pathological staging: This invention provides reagents and methods for assessing tumor progression using tissue or tumor cell-containing samples from an individual. The invention also provides reagents and methods for assessing response to chemotherapy.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070207471 - Semiconductor dna sensing device and dna sensing method: A semiconductor DNA sensing device having a detection section is provided. The detection section comprises a structure of a probe DNA/a first organic monolayer/an insulating layer/a semiconductor. The field-effect transistor (FET) comprises a semiconductor substrate and a first insulator layer formed thereon as a reactive gate insulator, and the first... Agent: Birch Stewart Kolasch & Birch

20070207491 - Sirna targeting minichromosome maintenance deficient 4 (mcm4): Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed... Agent: Kalow & Springut LLP

20070207481 - Use of roma for characterizing genomic rearrangements: The present invention relates to methods and compositions for detecting genomic rearrangements (e.g., amplification) at one or more genetic loci and various applications of such methods and compositions. Examples of genetic loci include HER2, TOP2A and other loci on the human chromosome 17.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070207461 - Virus purification methods: The invention provides a method for the purification of a virus from a host cell, the method comprising the steps of: a) culturing host cells, b) infecting the host cells with a virus, c) treating the cell culture with nuclease, d) lysing the host cells to provide a lysate comprising... Agent: Trask Britt

20070207482 - Wobble sequencing: Novel methods and compositions for DNA sequencing are provided. The methods described herein are useful for sequencing homopolymeric regions of DNA. The methods also prevent the accumulation of mistakes and inefficiencies in the sequencing reaction.... Agent: Banner & Witcoff, Ltd.

20070207500 - Affinity chromatography matrices and methods of making and using the same: The invention provides methods of coupling protein ligands to a solid support. The invention also provides affinity chromatography matrices and methods of using affinity chromatography matrices to purify a target molecule.... Agent: Millipore Corporation

20070207502 - Cyclic peptides: Methods of producing cyclic peptides and splicing intermediates of peptides in a looped conformation are disclosed. The methods utilize the trans-splicing ability of split inteins to catalyze cyclization of peptides from a precursor peptide having a target peptide interposed between two portions of a split intein. The interaction of the... Agent: Akerman Senterfitt

20070207498 - Design and construction of dimeric concanavalin a mutants: Embodiments of the invention provide for compositions comprising purified polypeptides such as purified Concanavalin A (ConA) mutants. In addition, embodiments provide for polypeptides and nucleic acids encoding those polypeptides, such as mutant ConA with reduced dimer-dimer interactions compared to wild type ConA. Some embodiments also provide for sensors comprising the... Agent: Nutter Mcclennen & Fish LLP

20070207503 - Detection of alcohol-esterified fatty acids: A method of producing an antibody recognizing a target fatty acid alcohol ester by immunizing an animal with a carrier protein conjugated with a derivative of the target fatty acid alcohol ester. A method of estimating alcohol consumption of an individual by quantitating levels of molecules which bind to antibodies... Agent: Kohn & Associates, PLLC

20070207496 - Diagnostic control system: A novel control system applicable in immunochromatographic analysis is provided, wherein the control system comprises a binding pair consisting of an antigen and an antibody, and wherein at the antigen a species-specific substance, and further provided that the antigen is not an antibody per se.... Agent: Christian D. Abel

20070207499 - Method for measuring a protein: The present invention provides a method for measuring a particular protein in a sample containing at least one protein, wherein the sample is reacted with a reagent cleaving a peptide bond of the particular protein to generate a soluble peptide fragment which is determined by a certain primary structure; and... Agent: Nixon & Vanderhye, PC

20070207497 - Receptor ligands and methods of modulating receptors: The invention provides natural ligands of various receptors and methods of identifying modulators of various receptors using the ligands. Methods of using the modulators to treat diseases or disorder associated with dysfunction of the receptor are also provided.... Agent: Banner & Witcoff, Ltd.

20070207506 - G-protein coupled receptor and dna sequences thereof: ICSR-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ICSR-1 polypeptides and polynucleotides in diagnostic assays.... Agent: Millen, White, Zelano & Branigan, P.C.

20070207507 - Biomarkers of vulnerable atherosclerotic plaques and methods of use: The present invention provides compositions suitable for use as biomarkers of vulnerable plaques as well as methods for the use of such compositions. In preferred embodiments, specific molecular imaging agents are provided that permit the selective identification of vulnerable plaques in coronary and other arteries using non-invasive imaging methods. Such... Agent: Mirick, O'connell, Demallie & Lougee, LLP

20070207508 - Method and assay kit for simultaneously detecting multiple tumor markers with interference indication: It is disclosed a method for simultaneous detection of multiple tumor markers, comprising the steps of: (a) mixing analyte samples, a first antibody solution and a second antibody solution, thereby forming a quaternary composite of “Second Antibody-Tumor Marker-First Antibody-bead”; (b) detecting the detectable signals from the distinct beads of the... Agent: Dorsey & Whitney LLP Intellectual Property Department

20070207510 - Methods and compounds for lymphoma cell detection and isolation: Compositions comprising a purified, isolated antibody, humanized antibodies and precipitates directed against ROR-1, wherein the antibody binds ROR-1 with moderate to high affinity. The compositions may be used for detecting and isolating an amount of ROR-1 in a subject sample, and to evaluate the appearance, status, course, or treatment of... Agent: Dla Piper US LLP

20070207511 - Methods for identification, assessment, prevention, and therapy of cancer: The present invention relates to the newly identified cancer therapeutic targets and biomarkers. These targets/biomarkers are overexpressed in carcinomas generally, and more specifically to adenocarcinoma and squamous cell carcinoma. The invention provides methods of diagnosis, characterization, and therapy of carcinoma based on the degree of overexpression of the targets/biomarkers.... Agent: Cohen, Pontani, Lieberman & Pavane

20070207509 - Zinc-based screening test and kit for early diagnosis of prostate cancer: The present invention provides methods of determining if an individual is at risk for prostate cancer. The methods measures and compares free and/or bound zinc levels in a semen sample or prostatic fluid, including post massage expressed prostatic fluid, in the potential at risk individual with normal levels. A decrease... Agent: Benjamin Aaron Adler Adler & Associates

20070207505 - Method for mesurement of apoliporotein b-48 and its use: The present invention provides a method for the measurement of apoB-48, which involves measuring the apoB-48 by diluting a sample with a tris-buffer and, as needed, a surfactant and reacting the diluted sample with an anti-apoB-48 monoclonal antibody, and a kit for measuring the apoB-48 by using the above method.... Agent: Birch Stewart Kolasch & Birch

20070207512 - Structure-based drug design methods for identifying d-ala-d-ala ligase inhibitors as antibacterial drugs: The invention is based on the discovery that certain small molecules can bind to the ATP binding site of D-Ala-D-Ala ligase, even in the absence of the enzyme's substrate, and can cause a conformational change in the enzyme structure similar to that which occurs upon binding of ATP and substrate... Agent: Darby & Darby P.C.

20070207514 - Fast microbiological analysis device and method: The method includes the step of procuring a device of the above kind, the step of disposing said support (19) at said predetermined location, the step of spraying said reagent onto said support (19) and, simultaneously with the spraying step, the step of measuring the quantity of light emitted in... Agent: Nields & Lemack

20070207515 - Method of multiquantification for cholesterol of low-density lipoprotein: Provided is a method of stabilizing a reagent that allows simultaneous quantification of LDL cholesterol and total cholesterol by a single measurement by suppressing spontaneous color development thereof A method of quantification for cholesterol in low density lipoprotein and total cholesterol in a biological sample by the single measurement comprises... Agent: Foley And Lardner LLP Suite 500

20070207517 - Breast milk ethanol screening system and method: A test kit detects presence of ethanol alcohol in human breast milk. The test kit includes an alcohol oxidase reactive in the presence of ethanol alcohol in breast milk and oxygen, an indicator having a visible color when not subjected to oxidizing agent, in sufficient amount for visible observance, and... Agent: H. Dale Langley, Jr. The Law Firm Of H. Dale Langley, Jr. PC

20070207518 - Membrane filter for microbe detection: A membrane filter for microbe detection that realizes low fluorescent background, being applicable to staining combining fluorescent dyes of variable wavelengths, and that attains enhanced operationality. There is provided a membrane filter for microbe detection, comprising a polymer layer of 10 to 500 μm thickness and, superimposed thereon, a metal... Agent: Hoffmann & Baron, LLP

20070207519 - Cephalosporin c acylase mutant and method for preparing 7-aca using same: A CPC acylase mutant of the present invention has an improved reactivity and specific activity to CPC, which can be efficiently employed for directly preparing 7-ACA from CPC by a one-step enzymatic method.... Agent: Novartis Corporate Intellectual Property

20070207520 - Method for cell-free synthesizing protein using wheat embryo extract under low temperature condition: The subject of the present invention is to provide a method for cell-free protein synthesis which needs no new apparatus and reagent to allow production of a protein with a high quality by a large amount. To solve the matter described above, translation reaction is conducted at a temperature of... Agent: Kilyk & Bowersox, P.l.l.c.

20070207523 - Mammalian t-type calcium channels: Sequences and partial sequences for three types of mammalian (human and rat sequences identified) T-type calcium channel subunits which we have labeled as the α1G, α1H and α1I subunits are provided. Knowledge of the sequence of these calcium channel permits the localization and recovery of the complete sequence from human... Agent: Morrison & Foerster LLP

20070207521 - Novel phospholipases and uses thereof: The invention relates to a newly identified polynucleotide sequence comprising a gene that encodes a novel phospholipase isolated from Aspergillus niger. The invention features the full length nucleotide sequence of the novel gene, the cDNA sequence comprising the full length coding sequence of the novel phospholipase as well as the... Agent: Nixon & Vanderhye, PC

20070207524 - Phytase enzymes, nucleic acid sequences encoding phytase enzymes and vectors and host cells incorporating same: DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium, Fusarium, Humicola and Emericella. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the... Agent: H. Thomas Anderton, Jr. Genencor International, Inc.

20070207525 - Phytase enzymes, nucleic acid sequences encoding phytase enzymes and vectors and host cells incorporating same: DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium, Fusarium, Humicola and Emericella. Also provided for is a method of isolating DNA encoding an enzyme having phytase activity from organisms which possess such DNA, transformation of the DNA into a suitable host organism, expression of the... Agent: Genencor International, Inc. Attention: Legal Department

20070207522 - Use of lacritin in promoting ocular cell survival: The present invention relates to the use of lacritin, and fragments, derivatives, and homologs thereof, and nucleic acid sequences encoding that protein. The invention relates to the use of lacritin as a growth factor human corneal epithelial cells and other select epithelial cells. The invention also relates to the use... Agent: University Of Virginia Patent Foundation

20070207526 - Norovirus and sapovirus antigens: Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid proteins or other immunogenic viral polypeptides from one or more strains of Norovirus and/or Sapovirus, coexpression of such immunogenic viral polypeptides with adjuvants, and methods... Agent: Novartis Vaccines And Diagnostics Inc.

20070207527 - Enzymatic ammonolysis process for the preparation of intermediates for dpp iv inhibitors: An enzymatic ammonolysis process is provided for the preparation of intermediates used in preparing dipeptidyl peptidase IV inhibitors wherein the enzyme Candida antarctica lipase-B is used to catalyze the ammonolysis process.... Agent: Louis J. Wille Bristol-myers Squibb Company

20070207528 - Production of polyunsaturated fatty acids in oleaginous yeasts: The present invention relates to methods for the production of ω-3 and/or ω-6 fatty acids in oleaginous yeast. Thus, desaturases and elongases able to catalyze the conversion of linoleic acid (LA) to γ-linolenic acid (GLA); α-linoleic acid (ALA) to stearidonic acid (STA); GLA to dihomo-γ-linoleic acid (DGLA); STA to eicosatetraenoic... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070207529 - Production of (s)-2-butanol by oxidative racemate resolution: A method for producing (S)-2-butanol of an optical purity ee of >90% comprises reacting a biotransformation composition comprising, as starting materials, a racemic mixture of 2-butanol (rac-2-butanol), an oxidoreductase, a redox cofactor and a cosubstrate, (R)-2-butanol being selectively oxidized to 2-butanone, and (S)-2-butanol being retained in an optical purity ee... Agent: Brooks Kushman P.C.

20070207530 - Egvii endoglucanase and nucleic acids encoding the same: The present invention provides a novel endoglucanase nucleic acid sequence, designated eg/7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same.... Agent: Genencor International, Inc.

20070207531 - Methods and bacterial strains for producing hydrogen from biomass: A method is provided for producing hydrogen by fermenting a culture medium containing a sugar and maintained under substantially anaerobic conditions with a bacterium of the genus Clostridium. The bacterium may be Clostridium bifermentans and hydrogen may be produced with an efficiency of at least about 34% relative to the... Agent: Klarquist Sparkman, LLP

20070207532 - Mutants of o6-alkylguanine-dna alkyltransferase: The invention relates to AGT mutants showing, when compared to the wild type human AGT, two or more advantageous properties selected from (a) reduced DNA interaction; (b) localisation of the expressed protein in eukaryotic cells that is no longer restricted to the nucleus; (c) improved expression yield as soluble protein... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070207534 - Mobile bioremediation systems and methods: In some embodiments, a system may reduce contaminants in water. A system may include a biofilm in a container. The biofilm may be formed from one or more bacteria coupled to one or more substrates. The bacteria may be selected to maximize the reduction of contaminants in water. The system... Agent: Meyertons, Hood, Kivlin, Kowert & Goetzel, P.C.

20070207533 - Device and method for collection and biodegradation of hydrocarbon fluids: A portable, disposable device for the collection and bacteriological decomposition of liquid hydrocarbons including a pillow containing at least one member of the group consisting of (i) kenaf fibers/particles and (ii) a mixture of (a) natural, synthetic and/or oleophilic fibers/particles and (b)(i) one or more species of fungi selected from... Agent: Thorp Reed & Armstrong, LLP

20070207535 - Reaction container, and reaction device and detection device using the reaction container: A reaction container 101 having a substrate (102) in which a probe to detect a biologically associate substance is phase-locked, the reaction container (101) comprising a correcting section (105, 106, 107, 108, 109) to align a detection direction of a detector (129) to detect a reaction of the substrate and... Agent: Scully Scott Murphy & Presser, PC

20070207536 - Fluorescence biosensor: A fluorescence detector includes a light source being positioned so that in use, radiation emitted therefrom falls on one or more fluorescing species, and a photodetector being switchably connectable between a charge integrator device and a charge disposal device. The photodetector is positionable to detect fluorescent radiation from the fluorescing... Agent: Allen, Dyer, Doppelt, Milbrath & Gilchrist P.A.

20070207537 - Bioreactor: A cell culture plate for perfused cell or tissue culture comprises one or more wells. The wells are formed from a biocompatible gas permeable polymer. Means are provided to perfuse each well.... Agent: Nixon & Vanderhye, PC

20070207538 - Operation controller of culture tank: Provided is an operation controller of a culture tank which can more precisely control the internal state of the culture tank by specifying a relatively small number of internal state variables, thus constructing a mathematical model which describes intracellular conditions by using these internal state variables, and thereby incorporating observable... Agent: Mattingly, Stanger, Malur & Brundidge, P.C.

20070207539 - Rapid production of monoclonal antibodies: The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of making monoclonal antibodies. The present invention also provides populations of hybridomas and B cells that can be utilized to make a monoclonal... Agent: Needle & Rosenberg, P.C.

20070207542 - Manipulation of oxygen tension during in vitro follicle culture: A process for culturing an immature ovarian follicle in vitro is disclosed. The process includes providing a culture having one or more immature ovarian follicles and providing a sufficient amount of oxygen to the ovarian culture on an intermittent basis, stepwise basis, or continuously, or combinations thereof, for a sufficient... Agent: Craig G. Cochenour, Esq. Buchanan Ingersoll & Rooney PC

20070207540 - Method of producing three-dimensional tissue and method of producing extracellular matrix used in the same: The present invention provides a novel method of producing a three-dimensional tissue by which cell lamination can be carried out easily. According to the method, a three-dimensional tissue in which cell layers are laminated with an extracellular matrix intervening between each pair of the adjacent cell layers is produced by:... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20070207541 - Method of prevention of lysosomal leakage in eukaryotic cells by using 6-methyluracil based water-soluble compounds and method of producing thereof: A composition and method of preventing a lysosomal leakage from eukaryotic cells is based on a 6-methyluracil based water-soluble compound. The cells are being exposed to a water solution of such compound for the duration of a sub-optimal condition such as a temperature shock, starvation, radiation, etc. The optimum concentration... Agent: Boris Leschinsky

20070207543 - Defined surfaces of self-assembled monolayers and stem cells: A method for the construction of arrays from self-assembling monolayers is described. The arrays have particular utility for the screening of peptides ligands that can foster the growth of cells in culture. This technique has been used to identify peptide ligands that foster the growth of human stem cells, which... Agent: Quarles & Brady LLP

20070207544 - Stroma-free, serum-free, and chemically defined medium and method for ex vivo mononuclear cell expansion using the same: A stroma-free, serum-free, and chemically defined medium and a method for mononuclear cell expansion ex vivo using the same. An exemplary medium includes a basal medium, a serum substitute, and a cytokine formula.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070207545 - Novel animal cell expression vectors: In the present invention, in order to expand the range of drug resistance markers available for use in a transgenic vector for animal cells, an expression vector comprising a multicloning site identical to those of the existing vectors and drug resistance marker genes different from those of the existing vectors... Agent: Sughrue Mion, PLLC

20070207546 - Bovine immunodeficiency virus (biv) based vectors: This invention pertains to BIV constructs encompassing BIV combination vectors, BIV vectors and BIV packaging vectors and particularly the invention pertains to a three vector system comprising: a) a BIV vector construct including a DNA segment from a BIV genome, a packaging sequence to package RNA into virions; a promoter... Agent: Bell, Boyd, & Lloyd LLP