Chemistry: molecular biology and microbiology inventions 07/07

20070172837 - Flow cell comprising ports and methods for using the same: A flow cell having a plurality of independently controllable inlet and/or outlet ports is provided. In certain embodiments, a subject flow cell contains: a) a chamber having a plurality of independently controllable inlet ports and a plurality of independently controllable outlet ports; b) a first manifold in fluid communication with... Agent: Agilent Technologies Inc.

20070172851 - Functionalized carbon nanotubes: Carbon nanotubes are grown on a first substrate. The CNTs grown on the first substrate are immersed in a biological solution at a predetermined depth to functionalize ends of the CNTs with a biological molecule. The functionalized CNTs are harvested from the first substrate. A second substrate is functionalized with... Agent: Fish & Richardson P.C.

20070172852 - Non-destructive quality control methods for microarrays: Methods for non-destructive quality control of a synthetic round of fabrication of high density oligonucleotide arrays are disclosed.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070172845 - Nucleic acid probes and microarrays for analysis of polynucleotides: The invention provides a probe for detecting a target polynucleotide. The probe contains a region that base-pairs with a target polynucleotide to form a duplex and a RNA hairpin extension domain that increases the stability of the duplex. The probe may further include a nucleotide clamp, a stem-complementary region and/or... Agent: Agilent Technologies Inc.

20070172840 - Parallel microarray hybridization: A glass substrate with multiple identical microarrays is provided, for example, for the identification of genes via nucleic acid hybridization. The multiarray substrate permits the analysis, in parallel, of several different samples on the same substrate and thus under the same conditions. Results obtained using the multiarray substrate are therefore... Agent: Fellers Snider Blankenship Bailey & Tippens

20070172891 - Screening method and apparatus: Reference data are subtracted from corresponding actual measurement data, and unprocessed binding quantity data, each of which represents a quantity of binding of a ligand and each of analytes, are thereby acquired. Calculation is made to find a relationship between the reference data and the unprocessed binding quantity data acquired... Agent: Sughrue Mion, PLLC

20070172912 - Method for fluorescently staining tissue: It is intended to provide a method for fluorescently staining a tissue accurately and clearly by convenient procedures and a staining agent used in this method. The present invention provides a method for fluorescently staining a tissue, comprising treating a tissue with a solution comprising fluorescein or a salt thereof... Agent: Greenblum & Bernstein, P.L.C

20070172811 - Preserving hypoxic tissue: Hypoxic tissue is preserved by prophylactically administering Stromal Derived Factor 1 Alpha (SDF-1α) before hypoxia induces cell death in the tissue.... Agent: Richard Aron Osman

20070172812 - Tissue equivalent for transplantation and method for producing same: A tissue equivalent for transplantation having a three-dimensional structure which is cultured in vitro, contains cells to be transplanted and which can be transplanted into a living body after the culture, characterized by including a scaffold layer mainly culturing a scaffold constituting the three-dimensional structure and a cell layer which... Agent: Sughrue Mion, PLLC

20070172815 - Method for detecting modulators of ion channels using thallium (i) sensitive assays: Disclosed and claimed herein are novel thallium-sensitive assays for identifying modulators of ion channels, channel-linked receptors or ion transporters. Further described are novel chloride-free buffers and low chloride cell growth media.... Agent: Louis J. Wille Bristol-myers Squibb Company

20070172813 - Method for evaluating drug candidates: Two-dimensional and/or three-dimensional polymeric or extended solid arrays comprising a polydiacetylene backbone, are used to evaluate the organic/water partition coefficient and/or oral absorptivity and/or ability of a compound to diffuse into cell membranes and/or transcellular permeability properties of a compound and/or the ionization state of a compound and/or the volume... Agent: Connolly Bove Lodge & Hutz LLP

20070172814 - Method of testing the safety and efficacy of a drug: A method of testing the safety and efficacy of a drug in a culture tray having a plurality of wells surrounded by a chamber wall configured to contain a liquid volume. The method includes depositing different cells of an organism in separate wells of the culture dish, depositing a harmful... Agent: Kevin J. Mcneely, Esq.

20070172819 - Enzymatic nucleic acid synthesis: compositions including pyrophosphorolysis inhibitors: Nucleotide triphosphate probes containing a molecular and/or atomic tag on a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are... Agent: Robert W Strozier, P.l.l.c

20070172820 - Methods for drug discovery, disease treatment, and diagnosis using metabolomics: The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.... Agent: Lahive & Cockfield, LLP

20070172817 - Methods of producing antibodies for diagnostics and therapeutics: Provided herein are methods for making and screening antibodies. Methods may include injecting a plurality of antigens or nucleic acids encoding antigens into a host. Methods may also include using fusion proteins of an antigen to a carrier protein for preparing and/or screening antibody preparations. The methods may be used... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070172818 - Multiparameter facs assays to detect alterations in cellular parameters and to screen small molecule libraries: The invention relates to novel methods of detecting alterations in cell cycle regulation in a cell or a cell population and screening for agents capable of modulating cell cycle regulation through the use of multiparameter assays and a fluorescence-activated cell sorter (FACS) machine.... Agent: Bozicevic, Field & Francis LLP

20070172816 - Phage-display plant defense peptides directed against phakopsora pachyrhizi and uromyces appendiculatus: A method for the identification of peptides having an affinity for the surface of fungi is provided as is a method for the identification of peptides capable of affecting the development of a fungus. Also provided are compositions comprising peptides identified using the method of the present invention. In addition,... Agent: Lathrop & Gage Lc

20070172830 - Antibodies to hhpen62 polypeptide: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070172838 - Assay for mycobacterium avium/intracellulare nucleic acid: Disclosed is a method for determining the presence of Mycobacterium avium complex nucleic acids in a biological sample. In particular, the mig gene of M avium and the DT1 gene of M. intracellulare are detected, preferably following amplification. In addition, the method distinguishes between species of M avium and M... Agent: Richard J. Warburg Foley & Lardner LLP

20070172821 - Assembly of chitosan onto an electrode surface: The deposition of chitosan onto electrode surfaces is disclosed. Methods of depositing chitosan on surfaces are disclosed. Materials comprising chitosan deposited on a substrate are also disclosed.... Agent: Edell, Shapiro & Finnan, LLC

20070172839 - Asymmetrical adapters and methods of use thereof: A pair of asymmetrical, partially double-stranded oligonucleotide adapters are provided wherein the pair of adapters comprise a first asymmetrical oligonucleotide adapter comprising a single-stranded 3′ overhang and a second asymmetrical double-stranded oligonucleotide adapter comprising a single-stranded 5′ overhang and at least one blocking group on the strand of said second... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070172883 - Comparative fluorescence hybridization to nucleic acid arrays: The present invention provides methods of determining relative copy number of target nucleic acids and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acids immobilized on a solid surface, to which a sample comprising two sets of differentially labeled nucleic acids are... Agent: Bingham Mccutchen LLP

20070172864 - Composition for sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172874 - Compositions and methods for nucleic acid extraction from biological samples: Methods and compositions for extracting nucleic acids from a biological sample are provided. The extraction compositions contain a protease enzyme such as proteinase K at alkaline pH with little or no surfactant present. Extraction can be efficiently performed in 60 minutes or less at room temperature for certain mammalian tissue... Agent: Senniger Powers

20070172875 - Compositions and methods for nucleic acid extraction from biological samples: Methods and compositions for extracting nucleic acids from a biological sample are provided. The extraction compositions contain a protease enzyme such as proteinase K at alkaline pH with little or no surfactant present. Extraction can be efficiently performed in 60 minutes or less at room temperature for certain mammalian tissue... Agent: Senniger Powers

20070172863 - Compositions and methods for sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172868 - Compositions for sequence determination using tagged polymerizing agents and tagged monomers: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172862 - Data stream determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172849 - Detection of markers in nascent proteins: The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives, or substances recognized by the protein synthesizing... Agent: Medlen & Carroll, LLP

20070172826 - Electrochemically active ligand for sequence-specific detection of double-stranded nucleic acid molecule: wherein “A” represents a divalent ferrocene-containing linker or ferrocene-1,1′-yl, R2 represents a hydrogen atom or alkyl; “n” and “m” represent any natural numbers; and “V” and “X” represent the pyrrole-imidazole-polyamide (PIPA); to a ligand consisting of said ferrocene compound for sequence-specific detection of double-stranded nucleic acid molecules; to a method... Agent: Birch Stewart Kolasch & Birch

20070172860 - Enzymatic nucleic acid synthesis: compositions and methods: Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents... Agent: Robert W Strozier, P.l.l.c

20070172859 - Enzymatic nucleic acid synthesis: methods for direct detection of tagged monomers: Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents... Agent: Robert W Strozier, P.l.l.c

20070172869 - Enzymatic nucleic acid synthesis: methods for inhibiting pyrophosphorolysis during sequencing synthesis: Nucleotide triphosphate probes containing a molecular and/or atomic tag on a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are... Agent: Robert W Strozier, P.l.l.c

20070172854 - Gene expression analysis using array with immobilized tags of more than 25 bp (supersage-array): This invention provides a method of gene expression analysis that enables extensive gene expression analysis and simultaneous analysis of multiple samples of organisms for which genomic analysis has not yet been advanced. In this method, tags each comprising an oligonucleotide of more than 25 bp for identifying expressed genes, wherein... Agent: Birch Stewart Kolasch & Birch

20070172833 - Gene expression profile retrieving apparatus, gene expression profile retrieving method, and program: In a gene expression profile retrieving apparatus, while gene expression profile data acquired with different platforms can be used, a cell can be retrieved based upon a gene expression profile. The gene expression profile retrieving apparatus is provided with: a gene expression profile DB stores gene expression profiles of known... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070172828 - Genetic algorithms for optimization of genomics-based medical diagnostic tests: In a genetic optimization method, the genes of a chromosome population are computationally genetically evolved. The evolving includes evolving a number of expressed genes in each chromosome and employing a fitness criterion evaluated without reference to unexpressed genes of each chromosome. An optimized chromosome produced by the genetic evolving is... Agent: Philips Intellectual Property & Standards

20070172882 - Identification of a family of secreted proteins in vascular endothelium: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may... Agent: Millennium Pharmaceuticals, Inc.

20070172844 - Individualized cancer treatments: The invention provides for compositions and methods for predicting an individual's responsitivity to cancer treatments and methods of treating cancer. In certain embodiments, the invention provides compositions and methods for predicting an individual's responsitivity to chemotherapeutics, including platinum-based chemotherapeutics, to treat cancers such as ovarian cancer. Furthermore, the invention provides... Agent: Morrison & Foerster LLP

20070172856 - Materials and methods for treating chronic fibrotic diseases: Methods and compositions for the treatment of fibrosing diseases are described. More specifically, the invention demonstrates that inhibiting or otherwise decreasing the activity of CCL21 either alone or in combination with CCL19 will be effective in reducing the presence of fibrotic lesions and ameliorating the symptoms of fibrosing disorders.... Agent: Marshall, Gerstein & Borun LLP

20070172843 - Mek interacting protein 1 as diagnostic and therapeutic target for breast cancer treatment and prevention: A method for determining whether endocrine therapy is contra-indicated in an individual, including detecting the presence of MP1 protein. A method for identifying an inhibitor of MP1 activity in a mammary cell.... Agent: Price Heneveld Cooper Dewitt & Litton, LLP

20070172824 - Method for amplifying unknown dna sequence adjacent to known sequence: The present invention relates to a method for amplifying an unknown nucleotide sequence adjacent to a known nucleotide sequence, which comprises the step of (a) performing a primary amplification of said unknown nucleotide sequence using a DNA walking annealing control primer (DW-ACP) and a first target-specific primer; in which said... Agent: Clark & Elbing LLP

20070172872 - Method for attachment of silylated molecules to glass surfaces: A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070172823 - Method for conducting non-invasive early detection of colon cancer and/or of colon cancer precursor cells: The invention relates to a method for conducting non-invasive early detection of colon cancer and/or of colon cancer precursor cells, by using primers with which mutation analyses can be carried out in selected regions of genes APC, K-ras, β-catenin and B-raf. The invention also relates to a kit containing said... Agent: Norris, Mclaughlin & Marcus, P.A.

20070172884 - Method for detection of multiple test materials in a sample: A method for sequentially detecting multiple target nucleic acid fragments in a sample includes steps of adding a sample into a column having a test snare which has thereon two or more single strand capture DNA sequences; wherein each capture sequence binds specifically with one target nucleic acid fragment, and... Agent: Yi Li

20070172870 - Method for diagnosing selected adenocarcinomas: A method for the early diagnosing of selected adenccarcinomas in a human comprising the steps of removing a bodily sample from the human, and assaying the bodily sample for elevated expression of a specific gene. The gene being assayed for in the bodily sample is the TGFB-4 gene (hereinafter referred... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070172876 - Methods and compositions for diagnosing and suppressing metastasis thereof: Disclosed is a method for determining metastatic potential of tumors, a method and a composition for treating/suppressing metastasis of cancers, as well as a method for obtaining a metastasis suppressor. A particular aspect of the invention relates to a method and a composition of evaluating expression levels of connective tissue... Agent: Wpat, PC Intellectual Property Attorneys

20070172825 - Methods and kits for identifying functions and binding substances of gene products: [Means to Solve the Problems] At least one gene product is added to a compound cocktail such as a metabolic compound cocktail containing all of the metabolic substances, coenzymes, and such involved in a certain metabolic system, the mixture is reacted, and then a change occurred in the compound cocktail... Agent: Lahive & Cockfield, LLP

20070172836 - Methods for detecting nucleic acids using multiple signals: Disclosed is are methods for identifying a nucleic acid in a sample. In one example, the method includes: (a) contacting the nucleic acid in the sample with an oligonucleotide that is specific for the nucleic acid in the sample and that is labeled with at least a first fluorescent dye;... Agent: Richard J. Warburg Foley & Lardner LLP

20070172885 - Methods for drug discovery, disease treatment, and diagnosis using metabolomics: The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.... Agent: Lahive & Cockfield, LLP

20070172842 - Methods for isolating and identifying novel target-specific structuremers for use in the biological sciences: Described are methods for isolating and identifying structuremers that specifically associate with non-nucleic acid target molecules. Each such structuremer species preferably minimally comprises a nucleic acid mimic capable of hybridizing to a substantially complementary single-stranded nucleic acid molecule under stringent hybridization conditions. Structuremers may also include tags to facilitate separation... Agent: Biotechnology Law Group C/o Portfolioip

20070172877 - Methods for preventing cattle reproductive diseases: The present invention relates to methods for treating or preventing diseases or disorders in a pregnant cow and calf nursing a pregnant cow caused by infection by Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2, Bovine Herpes Virus Type-1 (BHV-1), Bovine Respiratory Syncytial Virus (BRSV), Parainfluenza Virus (PIV3), Campylobacter... Agent: Peter I. Bernstein Scully, Scott, Murphy & Presser, P. C.

20070172871 - Methods for profiling transcriptosomes: The present invention concerns a method for profiling variations in gene transcription (e.g., variable RNA processing) from complex and/or unknown genomic regions. Rather than screening EST or cDNA libraries for transcripts of interest, the method of the invention involves the reverse, i.e., using the genetic locus responsible for the gene... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070172858 - Methods for sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172867 - Methods for sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172866 - Methods for sequence determination using depolymerizing agent: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172846 - Methods for the production and purification of adenoviral vectors: The present invention relates to compositions comprising and methods for producing adenovirus compositions wherein host cells are grown in a bioreactor and purified by size partitioning purification to provide purified adenovirus compositions.... Agent: Fulbright & Jaworski L.L.P.

20070172878 - Methods using novel chemiluminescent labels: Methods using chemiluminescent label compounds and chemiluminescent labeled conjugates are provided. The compounds comprise an acridan ring bearing an exocyclic ketene dithioacetal group and further contain a labeling substituent which permits attachment to compounds of interest. The novel chemiluminescent compounds and labeled conjugates are convenient to prepare, are highly stable,... Agent: Lumigen, Inc.

20070172873 - Molecular counting: The invention provides methods and compositions for counting molecules in a sample, wherein each molecule is labeled with a unique oligonucleotide tag. Such tags are amplified and identified rather than the molecules themselves; that is, the problem of counting molecules is converted into the problem of counting tags. In one... Agent: Bozicevic, Field & Francis LLP

20070172847 - Molecular signaling pathways triggered by rituximab: prognostic, diagnostic, and therapeutic uses: The present invention provides markers associated with activated molecular signaling pathways (example: p38 MAKP, NF-κB, ERK1/2, YY-1 and AKT) inhibited by rituximab in cancer cells as well as pathways activated by rituximab (such as death receptors, RKIP, PTEN) all of which are associated with the regulation of chemo and immunoresistance.... Agent: Townsend And Townsend And Crew, LLP

20070172835 - Multiplex detection of respiratory pathogens: The present invention is directed to methods, compositions and kits for multiplex detection of pathogens, such as respiratory pathogens.... Agent: Lawrence Livermore National Laboratory

20070172827 - Multiplex detection probes: The present invention comprises detection probes utilizing vesicles or soluble bodies to retain multiple mass tag molecules. The detection probes may be used to simultaneously assay a plurality of different biological samples, each comprising a plurality of analytes, by immobilizing the analytes from each of the samples on a surface... Agent: Knobbe Martens Olson & Bear LLP

20070172861 - Mutant polymerases: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172848 - Novel calpastatin (cast) alleles: Disclosed herein are novel alleles characterized by polymorphisms in the CAST gene. The alleles may be used to genetically type animals. In a preferred embodiment, the alleles may be used as markers for animal meat quality and/or growth. Methods for identifying such markers, and methods of screening animals to determine... Agent: Mckee, Voorhees & Sease, P.L.C

20070172850 - Novel chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070172881 - Novel essential fungal polynucleotides, polypeptides, and methods of use: The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.... Agent: Louis J. Wille Bristol-myers Squibb Company

20070172855 - Nucleic acid purification with a binding matrix: The present invention relates to methods, kits, and compositions for generating purified RNA samples and purified DNA samples. In particular, the present invention provides methods for generating a purified RNA or DNA sample from a sample containing both DNA and RNA molecules using a binding matrix that preferentially binds DNA... Agent: Medlen & Carroll, LLP

20070172829 - Oligonucleotides and methods for detecting borrelia burgdorferi: The present invention provides methods and compositions for determining the presence and/or amount of Borrelia burgdorferi nucleic acids in a test sample related to Lyme disease. In particular, substantially purified oligonucleotide primers and probes are described that can be used for qualitatively and quantitatively detecting Borrelia burgdorferi nucleic acid in... Agent: Foley & Lardner LLP

20070172832 - Phosphonate fluorescent dyes and conjugates: Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates.... Agent: Townsend And Townsend And Crew, LLP

20070172880 - Polynucleotide encoding a novel trp channel family member, trp-plik2, and splice variants thereof: The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention... Agent: Louis J. Wille Bristol-myers Squibb Company

20070172857 - Primer and method for detecting lymph node metastasis: The present invention relates to a primer and method for detecting lymph node metastasis of a cancer cell derived from a colon cancer by detecting a marker in a sample prepared from a lymph node obtained from a living body, wherein the marker is a mRNA or a fragment of... Agent: Sughrue Mion, PLLC

20070172841 - Probe/target stabilization with add-in oligo: The invention relates to analyzing a sample containing small RNAs. In exemplary embodiments, the sample is contacted with an array in the presence of an add-in oligo. In typical embodiments, probes on the array include regions that are complementary to small RNAs and regions that are complementary to the add-in... Agent: Agilent Technologies Inc.

20070172822 - Prokaryotic dna repair ligases: The present invention relates to the cloning and characterisation of a prokaryotic DNA repair ligase, which is shown to possess a range of activities that allow the ligation and repair of non-compatible DNA ends and double strand breaks (DSBs). The enzyme has a range of applications in the manipulation and... Agent: Klarquist Sparkman, LLP

20070172831 - Schizophrenia gene signatures and methods of using the same: Compositions and methods that are useful for the diagnosis and treatment of schizophrenia are provided. More specifically, “gene signatures” are described that are characteristic of schizophrenia in an individual. The specific classes of genes that can be identified from these signatures are useful in that they provide the basis for... Agent: Darby & Darby P.C.

20070172865 - Sequence determination in confined regions: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172834 - Stable metal/conductive polymer composite colloids and methods for making and using the same: Stable metal/conductive polymer composite colloids and methods for making the same are provided. The subject colloids find use in a variety of different applications, including analyte detection applications. Also provided are kits that include the subject colloids.... Agent: Bozicevic, Field & Francis LLP

20070172879 - Thermophilic dna polymerases from thermoactinomyces vulgaris: The present invention provides compositions comprising thermostable DNA polymerases derived from hyperthermophilic eubacteria. In particular, the present invention comprises thermostable DNA polymerases from the hyperthermophilic eubacterial species Thermoactinomyces vulgaris. The present invention also provides methods for utilizing naturally-occurring and non-naturally-occurring forms of T. vulgaris DNA polymerase in sequencing, reverse transcription,... Agent: Medlen & Carroll, LLP

20070172853 - Use of deletion polymorphisms to predict, prevent, and manage histoincompatibility: Disclosed herein are methods for predicting the immunocompatibility of two subjects that include determining the presence or absence of one or more deletion variants in the DNA sequence of a gene, where the deletion variant substantially prevents expression of the protein encoded by the gene.... Agent: Clark & Elbing LLP

20070172889 - Human zven polypeptides: The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The... Agent: Zymogenetics, Inc. Intellectual Property Department

20070172890 - Magnetic rotation to improve signal-over-background in biosensing: The invention provides a method and a device (10) for distinguishing a specific binding from a less specific binding between at least one magnetic nanoparticle (11) and a surface of another entity by applying a magnetic field and detecting a physical parameter relating to magnetic nanoparticle rotational or motional freedom... Agent: Philips Intellectual Property & Standards

20070172888 - Measuring troponin antibodies to assess cardiovascular risk: This invention relates to the field of myocardial disorders. It discloses that antibodies to a cardiac troponin found in a sample obtained from an individual can be used as a diagnostic marker, especially in the assessment of an individual's risk of developing a myocardial disorder. A method aiding in the... Agent: Roche Diagnostics Operations Inc.

20070172887 - Monoclonal antibody based biomarker discovery and development platform: A method or platform for monoclonal antibody based biomarker discovery is disclosed. The method according to the invention provides for the integration of analyte collection, hybridoma screening and nanovolume integrated mass spectrometry (NVIMS) to achieve a robust screening system that is capable, for example, of cutting 4-6 years off of... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20070172892 - Novel polypeptide esdn, polynucleotides encoding the polypeptide, and utility of the polypeptide: The invention discloses a useful and novel factor (polypeptide) which plays an important role for morbid vascular smooth muscle in restenosis after percutaneous transluminal coronany angioplasty (PTCA) and arterial sclerosis in the field of cardiovascular system.... Agent: Sughrue Mion, PLLC

20070172886 - Reaction module for biological analysis: The present invention relates to a reaction module for biological analysis comprising the injection of biological fluid and/or of reagent allowing a determined biological reaction comprising at least one means for controlling the quantity of biological fluid and/or of reagent injected.... Agent: Oliff & Berridge, PLC

20070172893 - Recombinant platelet collagen receptor glycoprotein vi and its pharmaceutical use: The invention relates to Glycoprotein VI (GPVI), its isolation, purification, and methods for recombinant production. Especially, the invention relates to the use of GPVI, preferably recombinant GPVI, in the treatment of disorders and pathological events correlated directly or indirectly to blood coagulation disorders such as thrombotic and cardiovascular diseases. The... Agent: Millen, White, Zelano & Branigan, P.C.

20070172895 - Cd86 and cd80 receptor competition assays: The present invention discloses a method for assaying the binding of L104EA29YIg to a receptor. The receptor is preferably CD86 or CD80. The present invention also discloses antibodies to be used in the assay, as well as hybridomas expressing the antibodies.... Agent: Louis J. Wille Bristol-myers Squibb Company

20070172894 - Methods for screening cells and antibodies: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070172898 - Diagnostic test: A method of diagnosing intolerance by a subject to a specified substance which comprises incubating a leucocyte sample prepared from whole blood drawn from the subject with an extract of said substance and detecting whether or not PMNs in the sample have become activated.... Agent: Fulbright & Jaworski, LLP

20070172899 - Magnetic particle tagged reagents and techniques: Methods for separating, in a continuous, multizone fluid medium, cells, particles, or other molecules of interest (MOI) from associated or contaminating unwanted materials not of interest (MNOI). The invention involves forced movement of MOI into certain zones having properties which deter the entry of unwanted materials. Differential movement of MOI... Agent: Ralph T. Lilore

20070172902 - Biomarker for ovarian cancer: The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarker can be detected by SELDI mass spectrometry.... Agent: Edwards Angell Palmer & Dodge LLP

20070172900 - Diagnostic marker for cancer: The invention relates to the use of various proteins as diagnostic markers for cancerous diseases. In particular, the use of the annexin A3 protein is preferred. Preferably an increased regulation of annexin A3 is analysed in comparison to controls. The invention also relates to the use of active substances for... Agent: Nath & Associates

20070172901 - Method for the evaluation of the functional status of the growth factor receptor protein expressed in malignant tumors: A novel examination method for accurately evaluating the effectiveness of treatment with an anticancer drug for the administration of the anticancer drug targeting a tumor-associated factor receptor is provided. In order to evaluate the effectiveness of trastuzumab (Herceptin™) of an anticancer drug, it was found to be meaningful to examine... Agent: Jhk Law

20070172903 - Microfluidic device for cell separation and uses thereof: The invention features methods for separating cells from a sample (e.g., separating fetal red blood cells from maternal blood). The method begins with the introduction of a sample including cells into one or more microfluidic channels. In one embodiment, the device includes at least two processing steps. For example, a... Agent: Clark & Elbing LLP

20070172904 - Method for quantitative detection of biological toxins: The invention relates to analytical chemistry and to quantitative immunochemical analysis, in particular, to a method for immunochemical quantitative detection of various biological toxins by using biological microchips. A biological microchip comprises an ordered array of three-dimensional hydrogel cells on a solid support, which are produced by a method of... Agent: Ladas & Parry

20070172896 - Methods for cyclic nucleotide determination: The present invention relates in general to cellular analysis tools and more particularly to methods for detecting or determining cyclic nucleotide concentrations in samples.... Agent: Medlen & Carroll, LLP Suite 350

20070172897 - Methods and compositions for diagnosing ankylosing spondylitis using biomarkers: The invention provides a method for determining the efficacy of a TNFα inhibitor, such as a TNFα antibody, or an antigen-binding portion thereof, for treating ankylosing spondylitis (AS), using a collagen degradation biomarker and/or a synovitis biomarker.... Agent: Lahive & Cockfield, LLP

20070172905 - Method for screening process conditions of a chemical coupling reaction and kits therefor: The present invention relates to a method of screening the operating conditions of a coupling reaction of at least two functional groups, and in particular of catalysts that are useful in this coupling reaction, and also to kits suitable for allowing this method to be carried out. Applications: fundamental and... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070172906 - Latent protein c assays and their uses for diagnosis and/or prognosis in systemic inflammatory response syndromes: The present invention relates to methods and compositions for measuring latent protein C in test samples, particularly patient samples. The methods and compositions described are sensitive for latent protein C, relative to activated protein C.... Agent: Townsend And Townsend And Crew, LLP

20070172907 - Liver disease-related methods and systems: The invention provides diagnostic methods, kits, and systems, and related computer-readable media, which use multiple blood marker values, including serum and plasma marker values, to aid in the diagnosis of the status or progress of a liver disease in a patient. The invention also provides methods and systems, and related... Agent: John M. Paolino, Esq. Bayer Healthcare

20070172908 - Enteropathogenic e. coli is a separate genus pathogenic bacteria: An assay is provided which recognizes the absence of dehydrogenase in all pathogenic bacteria and its presence in nonpathogenic (conditionally pathogenic) bacteria creating the opportunity to separate and establish enteropathogenic Escherichia (EPE) in a pathogenic genus bacteria; genus Brilmanella. A method for diagnosing maladies of the bowel based on the... Agent: Flaster/greenberg P.C. 8 Penn Center

20070172909 - Non-ribosomal peptide synthetases and associated biosynthetic genes: The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.... Agent: Wyeth C/o Darby & Darby, P.C.

20070172910 - Food freshness indicator and food storage systems same: A freshness indicator comprises a support structure that is substantially impermeable to fluids. A test device is engaged with the support structure and includes a pathogen detection composition. The pathogen detection composition provides a prescribed visual indication when in the presence of a prescribed type of pathogens and/or a by-product... Agent: David Odell Simmons

20070172911 - Biological sample processing composition and method: A method and composition are disclosed that are useful for processing biological samples. In one aspect, a biological sample such as a tissue section is treated using a histochemical technique and is contacted with a lipid compound during the process to enhance the definition of cellular and sub-cellular features that... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20070172913 - Production of a fermentation product: A process of separating suspended solids from a fermentation liquor by subjecting the liquor to a solids-liquid separation stage, wherein the fermentation liquor is produced in a fermentation process for the production of a fermentation product, in which the liquor has been subjected to a temperature of at least 50°... Agent: Ciba Specialty Chemicals Corporation Patent Department

20070172915 - Glycoprotein synthesis: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a... Agent: Quine Intellectual Property Law Group, P.C.

20070172914 - Protein concentrate and an aqueous stream containing water-soluble carbohydrates: Disclosed are process for contacting a protein containing material with one or more wet-mill streams. The protein content of the protein containing material is increased.... Agent: Fish & Richardson P.C.

20070172917 - Cytokine receptor zalpha11: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can... Agent: Zymogenetics, Inc. Intellectual Property Department

20070172920 - Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells: A chimeric LL2 monoclonal antibody is described in which the complementarity determining regions (CDRs) of the light and heavy chains of the murine LL2 anti-B-lymphoma, anti-leukemia cell monoclonal antibody has been recombinantly joined to the human kappa and IgG1 constant region domains, respectively, which retains the immunospecificity and B-cell lymphoma... Agent: Rossi, Kimms & Mcdowell LLP.

20070172918 - Non aggregating fluorescent proteins and methods for using the same: Nucleic acid compositions encoding non-aggregating chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The proteins of interest are polypeptides that are non-aggregating colored and/or fluorescent proteins, where the non-aggregating feature arises from the modulation of residues in the N-terminus of the protein and... Agent: Bozicevic, Field & Francis LLP

20070172916 - Novel bacillus 029cel cellulase: The present invention provides a novel cellulase nucleic acid sequence, designated 029cel, and the corresponding 029cel amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding 029cel, recombinant 029cel proteins and methods for producing the same.... Agent: Victoria L Boyd Genencor International Inc

20070172919 - Wdr36 gene alterations and glaucoma: Disclosed herein is the mapping of a new adult-onset primary open-angle glaucoma (POAG) locus on 5q22.1 (GLC1G) and identification of its defective gene. Mutation screening of 7 candidate genes from the GLC1G critical region identified the WDR36 (WD40-Repeat 36) gene. Methods of detection, prognosis and diagnosis of the presence or... Agent: Cantor Colburn, LLP

20070172921 - Secretion, transcription and sporulation genes in bacillus clausii: The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods for producing proteins in such host cells, such as members of the... Agent: Kamrin T. Macknight Genencor International, Inc.

20070172922 - Secretion, transcription and sporulation genes in bacillus clausii: The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods for producing proteins in such host cells, such as members of the... Agent: Kamrin T. Macknight Genencor International, Inc.

20070172923 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070172924 - Increasing the stability of recombinant adult human apohemoglobin: The disclosure relates to recombinant adult human apohemoglobin (apo-rHb) in which the stability has been increased by replacement of an amino acid with a counterpart from another organism, such as a deep sea diving mammal. This mutated apo-rHb may be more stable and/or give higher production yields than unmutated adult... Agent: Baker Botts L.L.P. Patent Department

20070172925 - Ribonucleic acid compound and method of liquid-phase synthesis of oligonucleic acid compound: (wherein B represents adenine, guanine, cytosine or uracil or a modified form thereof; R21 represents aryl which may be substituted or a monocyclic or bicyclic heterocyclic group which may be substituted; R20 represents H or alkyl which may be substituted; and R1 represents a protecting group which can be removed... Agent: Darby & Darby P.C.

20070172929 - Cold-adapted influenza virus: The cold-adapted master strain A/Ann Arbor/6/60 7PI (H2N2) and progenitor wild type E2(3) viral strains have been deposited and their genomic sequences identified. Seven nucleotide differences were found between the sequences identified herein and the previously published sequences for cold-adapted A/Ann Arbor/6/60 genes. The cold-adapted live influenza virus of the... Agent: Johnathan Klein-evans

20070172927 - Immune complexes comprising proteins of human immunodeficiency virus type 2 (hiv-2), antibodies against proteins of hiv-2, methods and kits employing proteins of hiv-2, and immunogenic compositions comprising proteins of hiv-2: Four glycoproteins of apparent molecular weights 300,000, 140,000, 125,000, and 36,000 (gp300, gp140, gp125, and gp36) are detectable in human immunodeficiency virus type 2 (HIV-2) infected cells. The gp125 and gp36 are the external and transmembrane components, respectively, of the envelope glycoproteins of HIV-2 mature virions. The gp300, which is... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070172928 - Immunoglobulin chimeric monomer-dimer hybrids: The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070172926 - Methods and compositions for identifying and characterizing hepatitis c: The invention provides novel methods and compositions for amplifying portions of the HCV genome. The nucleic acid sequences set forth as SEQ ID NOS:1-64 derived from HCV cDNA and functional equivalents thereof, kits containing same, and methods employing same, are useful for the identification and characterization of HCV in biological... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070172930 - Process for the selection of hiv-1 subtype c isolates, selected hiv-1 subtype isolates, their genes and modifications and derivatives thereof: The invention provides a process for the selection of HIV-1 subtype (clade) C isolates, selected HIV-1 subtype C isolates, their genes and modifications and derivatives thereof for use in prophylactic and therapeutic vaccines to produce proteins and polypeptides for the purpose of eliciting protection against HIV infection or disease. The... Agent: Kilpatrick Stockton LLP

20070172931 - Process for producing saccharide oligomers: A process for preparing saccharide oligomers uses an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and has a solids concentration of at least about 70% by weight. The feed composition is heated to a temperature of at least about 40° C., and is contacted... Agent: Williams, Morgan & Amerson

20070172932 - L-glutamic acid-producing microorganism and a method for producing l-glutamic acid: A coryneform bacterium which has an L-glutamic acid-producing ability and grows at least at the same growth rate as a non-mutated strain or a wild-type strain and has intracellular α-ketoglutarate dehydrogenase activity which is less than half that of the non-mutated or wild-type strain, and is obtained by introducing a... Agent: Cermak & Kenealy LLP Acs LLC

20070172933 - Thermally stable amidases: The invention relates to novel amidases which can be isolated from thermophilic bacteria, in particular from thermophilic Actinomycetes, e.g. Pseudonocardia thermophila, in which the resultant amidases not only have a high temperature stability, but are also distinguished by the enantioselective reaction of a broad substrate spectrum.... Agent: Connolly Bove Lodge & Hutz, LLP

20070172934 - Method for the production of flavor-active terpenes: Disclosed is a method for producing flavor-active terpenes from terpene hydrocarbons. According to said method, a lyophilized mycel which is first rehydrated and is then mixed with the substrate is used preferably in a submerged culture in the framework of selective biotransformation with the aid of microorganisms. The inventive method,... Agent: Morris Manning Martin LLP

20070172935 - Tank bioleaching process: A method of operating a tank bioleaching process of a concentrate, which includes the step of supplying carbon in a non-gaseous form to microbial cells used in the process.... Agent: Brinks Hofer Gilson & Lione

20070172936 - Purified active hcv ns2/3 protease: A method for producing a refolded, inactive form of recombinantly produced NS2/3 protease which comprises the steps of: a) purifying the protease from inclusion bodies in the presence of a chaotropic agent; and b) refolding the purified protease by contacting it with a reducing agent and lauryldiethylamine oxide (LDAO) in... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20070172937 - Recombinant cells that highly express chromosomally-integrated heterologous genes: Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide... Agent: Edwards Angell Palmer & Dodge LLP

20070172938 - Solid cellulosic culture medium and process for producing the same: The present invention relates to a solid medium containing as a medium-solidifying component a cellulose gel, in particular a cellulose gel which is a porous cellulose gel structure containing cellulose as the skeletal part and having a cellulose concentration of 0.01% or higher and a porosity of 50% or higher,... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070172939 - Real time electronic cell sensing system and applications for cell-based assays: The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In... Agent: David R Preston & Associates Apc

20070172941 - Disposable vessels or tips having ultra-thin areas therein, and methods for manufacture of same: The invention discloses disposable polymeric vessels or tip products, having a thin area upon at least a portion of the vessel or tip, for use in medical and scientific laboratories. The thin area has a thickness of less than 100 microns. Examples of such products are test-tubes, microtubes and multiwell... Agent: Edward Langer C/o Shiboleth Yisraeli Roberts Zisman & Co.

20070172940 - Fabrication and packaging of suspended microchannel detectors: An apparatus for detecting an analyte in solution that has a suspended beam containing at least one microfluidic channel containing a capture ligand that bonds to or reacts with an analyte. The apparatus also includes at least one detector for measuring a change in the beam upon binding or reaction... Agent: Choate, Hall & Stewart LLP

20070172942 - Apparatus for producing tissue arrays: An apparatus for producing a tissue array, having at least one donor block (2) that comprises tissue (3) to be investigated, is described. A marked tissue section of the tissue (3) to be investigated is arranged on a specimen slide (22), a hollow needle (5) for removing a sample from... Agent: Hodgson Russ LLP The Guaranty Building

20070172943 - Devices and methods for culturing, preserving, transporting, storing, reconstituting and assaying cellular materials: Devices, systems and methods for preparing, packaging and using biological materials are disclosed. Biological materials such as cellular or subscellular materials can be introduced in one or more complete assembled devices and preserved within the devices by, for example, being cooled or frozen. Such assembled devices can allow easy transportation... Agent: Knobbe Martens Olson & Bear LLP

20070172944 - Cell culture tool: A cell culture tool includes a cell culture tray and a dish or insert tray that rests on the cell culture tray. The cell culture tray includes a substantially flat surface with more than one well, each well configured to contain a liquid volume and an outer wall surrounding the... Agent: Kevin J. Mcneely, Esq.

20070172945 - Bioreactor: The present invention concerns a plunging jet bioreactor (1) comprising a mechanism (4), (5) adapted in use to form culture fluid into a hollow flow stream and to introduce into the hollow of the flow stream an oxygen-containing gas. In some embodiments the mechanism comprises concentrically arranged outer (4) and... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20070172946 - Lineage specific cells and progenitor cells: A method for generating a culture that is purified or enriched in respect of cells of a selected lineage is described in which a selectable marker, which is differentially expressed in cells of the selected lineage compared with its expression in other cells, is introduced into a multipotential cell and... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070172947 - Methods and compositions for expanding t regulatory cells: The present invention provides methods and compositions for expanding Treg cells ex vivo or in vivo using one or more conjugates comprising a costimulatory moiety that stimulates at least one of three signals involved in Treg cell development and/or using dendritic cells pulsed with antigens and modified to display TGF-β,... Agent: Foley And Lardner LLP Suite 500

20070172948 - Double strand compositions comprising differentially modified strands for use in gene modulation: The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having a gapped motif and another strand having a gapped motif, a hemimer motif, a blockmer motif,... Agent: Woodcock Washburn LLP

20070172949 - Vectors and viral vectors, and packaging cell lines for propagating same: Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vectors may include one or more native... Agent: Hunton & Williams LLP Intellectual Property Department

20070172950 - Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use of gene transfer: Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. Upon removal of a solubilizing component (i.e., detergent or an organic solvent) the lipid-nucleic acid complexes... Agent: Seed Intellectual Property Law Group PLLC

20070166730 - Magnetic resonance system and method to detect and confirm analytes: A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20070166774 - Functional immunoassay: Compositions, methods, and functional immunoassays for measuring functioning of organs, receptors, and biological processes in a subject are provided. Functional immunoassay combines pharmacokinetics of xenobiotics after administering one or more of the compositions to a subject by quantifying the xenobiotic in samples taken from the subject. The method provides a... Agent: Lawson & Weitzen, LLP

20070166801 - Compositions and methods for the treatment of influenza infection: The invention provides compositions of oligonucleotides targeted at influenza genes and at host animal genes involved in response to influenza infection. In some embodiments, the oligonucleotides are modified. In some embodiments, the compositions contain one, or more than one, oligonucleotide. The invention also provides methods and kits using the compositions... Agent: Wilson Sonsini Goodrich & Rosati

20070166694 - Composition and method to increase mammalian sperm function: A composition of matter for increasing the motility and/or percentage of intact acrosomes (PIA) in sperm is described. The composition includes, in combination, an amount of FAA and an amount of TIMP-2, wherein the amounts are effective to increase the motility, the PIA, or the motility and PIA of sperm... Agent: Dewitt Ross & Stevens S.c.

20070166696 - Adenovirus-transfected primary cells and methods of pathway mapping: A primary cell culture is transfected with a vector comprising a reporter gene operatively linked to a cis-element. Expression of a candidate regulatory protein is induced in the cell culture and its effects on the cis-element are assayed.... Agent: Ross J. Oehler Sanofi-aventis U.s. LLC

20070166698 - Assay method for drugs to treat atherosclerosis, cancer and alzheimer's disease: An assay to screen for potentially beneficial drugs against atherosclerosis, cancer and Alzheimer's disease, and their effectiveness in vitro. The assay is comprised of a system where LDL or cholesterol is given to various cells together with the drug being tested and then chromosome segregation and aneuploidy are detected using... Agent: Smith Hopen, Pa

20070166695 - Method for testing or screening for an enzyme of interest: The present invention relates to methods for testing or screening for an enzyme of interest.... Agent: Novozymes North America, Inc.

20070166697 - Synthesis and use of cross-linked hydrophilic hollow spheres for encapsulating hydrophilic cargo: Cross-linked hydrophilic nanocapsules and various compositions and methods for their preparation and use are provided.... Agent: Dechert LLP

20070166699 - Combination of anti-hpv-16 and 18 antibodies and uses thereof: The present invention relates to a combination of antibodies comprising (a) an anti-HPV-16 E7 antibody obtainable by (i) eliciting an in vivo humoral response against HPV-16 E7 protein or a fragment thereof in a goat; and (ii) affinity-purifying antibodies as obtained in the eliciting-step (i) and (b) an anti-HPV-18 E7... Agent: Foley And Lardner LLP Suite 500

20070166703 - Method of detecting pathogenic microorganism in real-time, using modified flow-type surface plasmon resonance biosensor: There is provided a method of detecting a pathogenic microorganism in real-time, using a modified flow-type surface plasmon resonance (SPR) biosensor, comprising the steps of: i) performing, in a batch-type, an immune reaction of a pathogenic microorganism and an antibody thereto; ii) selectively separating the pathogenic microorganism bound with the... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20070166701 - Methods for detecting flavivirus infection: The present invention encompasses isolated nucleic acids containing transcriptional units which encode a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a second flavivirus. The invention further encompasses a nucleic acid and protein vaccine and the use of the vaccine to immunize a subject against flavivirus infection.... Agent: Klarquist Sparkman, LLP

20070166702 - Methods for predicting the efficacy or outcome of hcv therapy: The present invention relates to a novel method for predicting likeliness of the outcome or efficacy of an antiviral therapy against Hepatitis C Virus (HCV). This method is based on the detection of antibodies against the proteins NSta and or NS5a in a sample of a patient. This method can... Agent: Clark & Elbing LLP

20070166700 - Sensing biological analytes on a ferroelectric transducer: A method of detecting a biological analyte within a sample (12) is provided. The analyte is one that can be electrically charged or polarized in the presence of an electric field. The sample is place in proximity with a ferroelectric transducer (14). An electric field is established to polarize the... Agent: Jacobson Holman PLLC

20070166744 - Analytical method and instrument: Subjects of the invention are a method for determination of an analyte using a particular algorithm based on a mathematical model for transforming measurement data into a growth curve and an analytical instrument comprising a computing unit for more precise determination of an analyte.... Agent: Roche Molecular Systems Inc Patent Law Department

20070166736 - Collagen xxii, a novel human collagen and uses thereof: The invention provides isolated nucleic acids molecules, designated collagen XXII nucleic acid molecules, which encode a novel collagen. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing collagen XXII nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in... Agent: Fish & Richardson PC

20070166739 - Comparative genomic hybridization on encoded multiplex particles: Disclosed herein are methods and compositions for evaluating genomic content using encoded particles to evaluate multiple samples in parallel.... Agent: Fish & Richardson PC

20070166755 - Compositions and methods for genetic analysis of polycystic kidney disease: The subject invention relates to nucleic acid sequences for detection of mutations in a PKD-1 or PKD-2 gene, as well as biomarkers for ADPKD. The invention further relates to methods for diagnosing ADPKD in an individual, and kits for performing the methods of the invention. The invention also provides a... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070166750 - Compositions and methods for nucleic acid extraction from biological samples: Methods and compositions for extracting nucleic acids from a biological sample are provided. The extraction compositions contain a protease enzyme such as proteinase K at alkaline pH with little or no surfactant present. Extraction can be efficiently performed in 60 minutes or less at room temperature for certain mammalian tissue... Agent: Senniger Powers

20070166751 - Compositions and methods for nucleic acid extraction from biological samples: Methods and compositions for extracting nucleic acids from a biological sample are provided. The extraction compositions contain a protease enzyme such as proteinase K at alkaline pH with little or no surfactant present. Extraction can be efficiently performed in 60 minutes or less at room temperature for certain mammalian tissue... Agent: Senniger Powers

20070166752 - Compositions and methods for nucleic acid extraction from biological samples: Methods and compositions for extracting nucleic acids from a biological sample are provided. The extraction compositions contain a protease enzyme such as proteinase K at alkaline pH with little or no surfactant present. Extraction can be efficiently performed in 60 minutes or less at room temperature for certain mammalian tissue... Agent: Senniger Powers

20070166707 - Computer systems and methods for associating genes with traits using cross species data: A method for confirming the association of a query QTL or a query gene in the genome of a second species with a clinical trait T exhibited by the second species. A first QTL or a first gene in a first species that is linked to a trait T′ is... Agent: Jones Day

20070166712 - Cyp2s1 as target for diagnosis and therapy of skin diseases: This invention relates to a retinoic acid metabolizing cytochrome P450 2S1 (CYP2S1) and to uses of sequence specific nucleic acid, primers and antibodies, in, for example, assays for the analysis of CYP2S1 messenger RNA and/or protein expression in skin. The invention also relates to assays for detecting agents which modulate... Agent: Darby & Darby P.C.

20070166722 - Detection mycobacterium: The present invention provides a method for determining the presence of Mycobacterium avium subspecies paratuberculosis (MAP) in a sample. The method involves using a pair of oligonucleotide probes and detecting the presence or absence of fluorescence resonance energy transfer (FRET) between the donor fluorescent moiety of the first probe and... Agent: Faegre & Benson LLP Patent Docketing

20070166733 - Detection of pkc-iota as a biomarker for brain tumorigenesis: A method of detecting brain tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the brain of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-iota and (c) comparing the expression level in (b) to a... Agent: Smith Hopen, Pa

20070166718 - Diagnostic and therapeutic use of mal2 gene and protein for neurodegenerative diseases: The present invention discloses the differential expression of the gene coding for MAL2 protein in specific brain regions of Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing or prognosticating Alzheimer's disease in a subject, or for determining whether a subject is at increased risk... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070166715 - Diagnostics and therapeutics for diseases associated with aminopeptidase-like 1 (npepl1): The invention provides a human NPEPL1 which is associated with the cardiovascular diseases, cancer, dermatological diseases, gastroenterological diseases, metabolic diseases, inflammation, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer,... Agent: Banner & Witcoff, Ltd.

20070166734 - Double strand compositions comprising differentially modified strands for use in gene modulation: The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having an alternating motif and another strand having a hemimer motif, a blockmer motif, a fully modified... Agent: Woodcock Washburn LLP

20070166721 - Fluidic circuits, methods and apparatus for use of whole blood samples in colorimetric assays: When the quantification of an analyte is based on a color change detected by a change in the amount of light transmitted or reflected, undiluted samples often saturate the detection range of the assay. Thus, very often, the sample needs to be diluted for reliable quantification. Disclosed are systems and... Agent: Knobbe Martens Olson & Bear LLP

20070166753 - Gene detection assay for improving the likelihood of an effective response to a her2 antibody cancer therapy: The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing HER2, as determined by a gene amplification assay, with a HER2 antibody. Such method comprises administering a cancer-treating dose of the HER2 antibody, preferably in addition to chemotherapeutic agents, to a subject... Agent: Genentech, Inc.

20070166727 - Genetic analysis and authentication: This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other... Agent: Eric P. Mirabez

20070166728 - Genetic profile imaging and data-sharing device and methodology for socially relevant traits: The present invention generally relates to genetic profiling and genetic data-sharing and, more particularly, is concerned with a system and method for genetic profile imaging and for determining and sharing information about a person's socially relevant traits. The present invention provides a means by which a person can safely share... Agent: Fredric Abramson

20070166746 - Human cytokine receptor: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”... Agent: Zymogenetics, Inc. Intellectual Property Department

20070166748 - Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor: The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member... Agent: Dykema Gossett PLLC

20070166723 - Hybridization-triggered fluorescent detection of nucleic acids: Compositions and methods for fluorescent detection of nucleic acids are provided. The compositions can be detected by fluorescence when hybridized to a nucleic acid containing a target sequence, but are non-fluorescent in the non-hybridized state. Alternatively, the fluorescence properties of the compositions change in a detectable manner upon hybridization to... Agent: Townsend And Townsend And Crew, LLP

20070166704 - Identification of polynucleotides and polypeptide for predicting activity of compounds that interact with protein tyrosine kinases and/or protein tyrosine kinase pathways: The present invention describes polynucleotides and polypeptides that have been discovered to correlate to the relative intrinsic sensitivity or resistance of cells, e.g., colon cell lines, to treatment with compounds that interact with and inhibit src tyrosine kinases. These polynucleotides and polypeptides have been shown, through a weighted voting cross... Agent: Louis J. Wille Bristol-myers Squibb Company

20070166709 - Immuno-pcr method: An immunoassay utilizing the polymerase chain reaction to detect biological molecules in a sample. In one embodiment, the method employs a plurality of nucleic acid templates with varying annealing temperatures when annealed to a detectable probe.... Agent: Crowell & Moring LLP Intellectual Property Group

20070166754 - In vitro cell-based methods for biological validation and pharmacological screening of chemical entities and biologicals: This patent describes a novel in vitro cell-based method for biological validation and pharmacological screening of drugs, new chemical entities (NCEs) and biologics, which is predictive of in vivo testing for efficacy and adverse events in patients, as occurs in clinical trials. The same method can be used to create... Agent: Cheryl H Agris Phd

20070166711 - Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof: Polynucleotide and polypeptide sequences for HFE2A, as well as mutations associated with juvenile hemochromatosis, and methods of utilizing these for the screening and identification of agents for the treatment of diseases of iron metabolism, including small organic compounds, are disclosed along with methods of treating and/or ameliorating diseases of iron... Agent: Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein

20070166738 - Markers for breast cancer: Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.... Agent: Quine Intellectual Property Law Group, P.C.

20070166729 - Method and reagent for sequencing: The present invention provides: a method for nucleic acid analysis including the steps of subjecting a reaction solution containing a sample nucleic acid to complementary strand synthesis with the sample nucleic acid as a template, reacting pyrophosphate produced in the complementary strand synthesis with 30 to 800 μM AMP in... Agent: Stanley P. Fisher Reed Smith LLP

20070166706 - Method for detecting biomolecules: The invention relates to a method for detecting biomolecules, particularly peptides, proteins, carbohydrates, glycoproteins, proteoglycans and/or nucleic acids by using a metal compound in the presence of at least one bifunctional agent.... Agent: Nath & Associates

20070166726 - Method for detecting radiation exposure: A method is disclosed for detecting exposure of organisms to biologically significant or hazardous amounts of ionizing radiation. The method uses nucleic acid microarray hybridization to evaluate biological effects, such as patterns of expression of genes after radiation exposure. Numerous genes are provided which have been found to be responsive... Agent: Klarquist Sparkman, LLP

20070166716 - Method for evaluating rnai activity and mirna activity: The present invention provides methods whereby an RNAi activity and a miRNA activity can be evaluated simply and conveniently. The RNAi activity or the miRNA activity is evaluated by supplying a target-expressing molecule, which is a polynucleotide containing at least a target sequence and an expression regulatory region regulating the... Agent: Foley And Lardner LLP Suite 500