Chemistry: molecular biology and microbiology inventions 07/07

20070172837 - Flow cell comprising ports and methods for using the same: A flow cell having a plurality of independently controllable inlet and/or outlet ports is provided. In certain embodiments, a subject flow cell contains: a) a chamber having a plurality of independently controllable inlet ports and a plurality of independently controllable outlet ports; b) a first manifold in fluid communication with... Agent: Agilent Technologies Inc.

20070172851 - Functionalized carbon nanotubes: Carbon nanotubes are grown on a first substrate. The CNTs grown on the first substrate are immersed in a biological solution at a predetermined depth to functionalize ends of the CNTs with a biological molecule. The functionalized CNTs are harvested from the first substrate. A second substrate is functionalized with... Agent: Fish & Richardson P.C.

20070172852 - Non-destructive quality control methods for microarrays: Methods for non-destructive quality control of a synthetic round of fabrication of high density oligonucleotide arrays are disclosed.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070172845 - Nucleic acid probes and microarrays for analysis of polynucleotides: The invention provides a probe for detecting a target polynucleotide. The probe contains a region that base-pairs with a target polynucleotide to form a duplex and a RNA hairpin extension domain that increases the stability of the duplex. The probe may further include a nucleotide clamp, a stem-complementary region and/or... Agent: Agilent Technologies Inc.

20070172840 - Parallel microarray hybridization: A glass substrate with multiple identical microarrays is provided, for example, for the identification of genes via nucleic acid hybridization. The multiarray substrate permits the analysis, in parallel, of several different samples on the same substrate and thus under the same conditions. Results obtained using the multiarray substrate are therefore... Agent: Fellers Snider Blankenship Bailey & Tippens

20070172891 - Screening method and apparatus: Reference data are subtracted from corresponding actual measurement data, and unprocessed binding quantity data, each of which represents a quantity of binding of a ligand and each of analytes, are thereby acquired. Calculation is made to find a relationship between the reference data and the unprocessed binding quantity data acquired... Agent: Sughrue Mion, PLLC

20070172912 - Method for fluorescently staining tissue: It is intended to provide a method for fluorescently staining a tissue accurately and clearly by convenient procedures and a staining agent used in this method. The present invention provides a method for fluorescently staining a tissue, comprising treating a tissue with a solution comprising fluorescein or a salt thereof... Agent: Greenblum & Bernstein, P.L.C

20070172811 - Preserving hypoxic tissue: Hypoxic tissue is preserved by prophylactically administering Stromal Derived Factor 1 Alpha (SDF-1α) before hypoxia induces cell death in the tissue.... Agent: Richard Aron Osman

20070172812 - Tissue equivalent for transplantation and method for producing same: A tissue equivalent for transplantation having a three-dimensional structure which is cultured in vitro, contains cells to be transplanted and which can be transplanted into a living body after the culture, characterized by including a scaffold layer mainly culturing a scaffold constituting the three-dimensional structure and a cell layer which... Agent: Sughrue Mion, PLLC

20070172815 - Method for detecting modulators of ion channels using thallium (i) sensitive assays: Disclosed and claimed herein are novel thallium-sensitive assays for identifying modulators of ion channels, channel-linked receptors or ion transporters. Further described are novel chloride-free buffers and low chloride cell growth media.... Agent: Louis J. Wille Bristol-myers Squibb Company

20070172813 - Method for evaluating drug candidates: Two-dimensional and/or three-dimensional polymeric or extended solid arrays comprising a polydiacetylene backbone, are used to evaluate the organic/water partition coefficient and/or oral absorptivity and/or ability of a compound to diffuse into cell membranes and/or transcellular permeability properties of a compound and/or the ionization state of a compound and/or the volume... Agent: Connolly Bove Lodge & Hutz LLP

20070172814 - Method of testing the safety and efficacy of a drug: A method of testing the safety and efficacy of a drug in a culture tray having a plurality of wells surrounded by a chamber wall configured to contain a liquid volume. The method includes depositing different cells of an organism in separate wells of the culture dish, depositing a harmful... Agent: Kevin J. Mcneely, Esq.

20070172819 - Enzymatic nucleic acid synthesis: compositions including pyrophosphorolysis inhibitors: Nucleotide triphosphate probes containing a molecular and/or atomic tag on a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are... Agent: Robert W Strozier, P.l.l.c

20070172820 - Methods for drug discovery, disease treatment, and diagnosis using metabolomics: The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.... Agent: Lahive & Cockfield, LLP

20070172817 - Methods of producing antibodies for diagnostics and therapeutics: Provided herein are methods for making and screening antibodies. Methods may include injecting a plurality of antigens or nucleic acids encoding antigens into a host. Methods may also include using fusion proteins of an antigen to a carrier protein for preparing and/or screening antibody preparations. The methods may be used... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070172818 - Multiparameter facs assays to detect alterations in cellular parameters and to screen small molecule libraries: The invention relates to novel methods of detecting alterations in cell cycle regulation in a cell or a cell population and screening for agents capable of modulating cell cycle regulation through the use of multiparameter assays and a fluorescence-activated cell sorter (FACS) machine.... Agent: Bozicevic, Field & Francis LLP

20070172816 - Phage-display plant defense peptides directed against phakopsora pachyrhizi and uromyces appendiculatus: A method for the identification of peptides having an affinity for the surface of fungi is provided as is a method for the identification of peptides capable of affecting the development of a fungus. Also provided are compositions comprising peptides identified using the method of the present invention. In addition,... Agent: Lathrop & Gage Lc

20070172830 - Antibodies to hhpen62 polypeptide: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070172838 - Assay for mycobacterium avium/intracellulare nucleic acid: Disclosed is a method for determining the presence of Mycobacterium avium complex nucleic acids in a biological sample. In particular, the mig gene of M avium and the DT1 gene of M. intracellulare are detected, preferably following amplification. In addition, the method distinguishes between species of M avium and M... Agent: Richard J. Warburg Foley & Lardner LLP

20070172821 - Assembly of chitosan onto an electrode surface: The deposition of chitosan onto electrode surfaces is disclosed. Methods of depositing chitosan on surfaces are disclosed. Materials comprising chitosan deposited on a substrate are also disclosed.... Agent: Edell, Shapiro & Finnan, LLC

20070172839 - Asymmetrical adapters and methods of use thereof: A pair of asymmetrical, partially double-stranded oligonucleotide adapters are provided wherein the pair of adapters comprise a first asymmetrical oligonucleotide adapter comprising a single-stranded 3′ overhang and a second asymmetrical double-stranded oligonucleotide adapter comprising a single-stranded 5′ overhang and at least one blocking group on the strand of said second... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070172883 - Comparative fluorescence hybridization to nucleic acid arrays: The present invention provides methods of determining relative copy number of target nucleic acids and precise mapping of chromosomal abnormalities associated with disease. The methods of the invention use target nucleic acids immobilized on a solid surface, to which a sample comprising two sets of differentially labeled nucleic acids are... Agent: Bingham Mccutchen LLP

20070172864 - Composition for sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172874 - Compositions and methods for nucleic acid extraction from biological samples: Methods and compositions for extracting nucleic acids from a biological sample are provided. The extraction compositions contain a protease enzyme such as proteinase K at alkaline pH with little or no surfactant present. Extraction can be efficiently performed in 60 minutes or less at room temperature for certain mammalian tissue... Agent: Senniger Powers

20070172875 - Compositions and methods for nucleic acid extraction from biological samples: Methods and compositions for extracting nucleic acids from a biological sample are provided. The extraction compositions contain a protease enzyme such as proteinase K at alkaline pH with little or no surfactant present. Extraction can be efficiently performed in 60 minutes or less at room temperature for certain mammalian tissue... Agent: Senniger Powers

20070172863 - Compositions and methods for sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172868 - Compositions for sequence determination using tagged polymerizing agents and tagged monomers: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172862 - Data stream determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172849 - Detection of markers in nascent proteins: The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives, or substances recognized by the protein synthesizing... Agent: Medlen & Carroll, LLP

20070172826 - Electrochemically active ligand for sequence-specific detection of double-stranded nucleic acid molecule: wherein “A” represents a divalent ferrocene-containing linker or ferrocene-1,1′-yl, R2 represents a hydrogen atom or alkyl; “n” and “m” represent any natural numbers; and “V” and “X” represent the pyrrole-imidazole-polyamide (PIPA); to a ligand consisting of said ferrocene compound for sequence-specific detection of double-stranded nucleic acid molecules; to a method... Agent: Birch Stewart Kolasch & Birch

20070172860 - Enzymatic nucleic acid synthesis: compositions and methods: Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents... Agent: Robert W Strozier, P.l.l.c

20070172859 - Enzymatic nucleic acid synthesis: methods for direct detection of tagged monomers: Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents... Agent: Robert W Strozier, P.l.l.c

20070172869 - Enzymatic nucleic acid synthesis: methods for inhibiting pyrophosphorolysis during sequencing synthesis: Nucleotide triphosphate probes containing a molecular and/or atomic tag on a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are... Agent: Robert W Strozier, P.l.l.c

20070172854 - Gene expression analysis using array with immobilized tags of more than 25 bp (supersage-array): This invention provides a method of gene expression analysis that enables extensive gene expression analysis and simultaneous analysis of multiple samples of organisms for which genomic analysis has not yet been advanced. In this method, tags each comprising an oligonucleotide of more than 25 bp for identifying expressed genes, wherein... Agent: Birch Stewart Kolasch & Birch

20070172833 - Gene expression profile retrieving apparatus, gene expression profile retrieving method, and program: In a gene expression profile retrieving apparatus, while gene expression profile data acquired with different platforms can be used, a cell can be retrieved based upon a gene expression profile. The gene expression profile retrieving apparatus is provided with: a gene expression profile DB stores gene expression profiles of known... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070172828 - Genetic algorithms for optimization of genomics-based medical diagnostic tests: In a genetic optimization method, the genes of a chromosome population are computationally genetically evolved. The evolving includes evolving a number of expressed genes in each chromosome and employing a fitness criterion evaluated without reference to unexpressed genes of each chromosome. An optimized chromosome produced by the genetic evolving is... Agent: Philips Intellectual Property & Standards

20070172882 - Identification of a family of secreted proteins in vascular endothelium: The invention relates to SCUBE molecules and generally to gene expression in vascular endothelial cells. The invention specifically relates to the discovery of a novel gene family containing the genes and proteins referred to herein as SCUBE1, SCUBE2 and SCUBE3 which can be expressed in endothelial cells. SCUBE proteins may... Agent: Millennium Pharmaceuticals, Inc.

20070172844 - Individualized cancer treatments: The invention provides for compositions and methods for predicting an individual's responsitivity to cancer treatments and methods of treating cancer. In certain embodiments, the invention provides compositions and methods for predicting an individual's responsitivity to chemotherapeutics, including platinum-based chemotherapeutics, to treat cancers such as ovarian cancer. Furthermore, the invention provides... Agent: Morrison & Foerster LLP

20070172856 - Materials and methods for treating chronic fibrotic diseases: Methods and compositions for the treatment of fibrosing diseases are described. More specifically, the invention demonstrates that inhibiting or otherwise decreasing the activity of CCL21 either alone or in combination with CCL19 will be effective in reducing the presence of fibrotic lesions and ameliorating the symptoms of fibrosing disorders.... Agent: Marshall, Gerstein & Borun LLP

20070172843 - Mek interacting protein 1 as diagnostic and therapeutic target for breast cancer treatment and prevention: A method for determining whether endocrine therapy is contra-indicated in an individual, including detecting the presence of MP1 protein. A method for identifying an inhibitor of MP1 activity in a mammary cell.... Agent: Price Heneveld Cooper Dewitt & Litton, LLP

20070172824 - Method for amplifying unknown dna sequence adjacent to known sequence: The present invention relates to a method for amplifying an unknown nucleotide sequence adjacent to a known nucleotide sequence, which comprises the step of (a) performing a primary amplification of said unknown nucleotide sequence using a DNA walking annealing control primer (DW-ACP) and a first target-specific primer; in which said... Agent: Clark & Elbing LLP

20070172872 - Method for attachment of silylated molecules to glass surfaces: A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070172823 - Method for conducting non-invasive early detection of colon cancer and/or of colon cancer precursor cells: The invention relates to a method for conducting non-invasive early detection of colon cancer and/or of colon cancer precursor cells, by using primers with which mutation analyses can be carried out in selected regions of genes APC, K-ras, β-catenin and B-raf. The invention also relates to a kit containing said... Agent: Norris, Mclaughlin & Marcus, P.A.

20070172884 - Method for detection of multiple test materials in a sample: A method for sequentially detecting multiple target nucleic acid fragments in a sample includes steps of adding a sample into a column having a test snare which has thereon two or more single strand capture DNA sequences; wherein each capture sequence binds specifically with one target nucleic acid fragment, and... Agent: Yi Li

20070172870 - Method for diagnosing selected adenocarcinomas: A method for the early diagnosing of selected adenccarcinomas in a human comprising the steps of removing a bodily sample from the human, and assaying the bodily sample for elevated expression of a specific gene. The gene being assayed for in the bodily sample is the TGFB-4 gene (hereinafter referred... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070172876 - Methods and compositions for diagnosing and suppressing metastasis thereof: Disclosed is a method for determining metastatic potential of tumors, a method and a composition for treating/suppressing metastasis of cancers, as well as a method for obtaining a metastasis suppressor. A particular aspect of the invention relates to a method and a composition of evaluating expression levels of connective tissue... Agent: Wpat, PC Intellectual Property Attorneys

20070172825 - Methods and kits for identifying functions and binding substances of gene products: [Means to Solve the Problems] At least one gene product is added to a compound cocktail such as a metabolic compound cocktail containing all of the metabolic substances, coenzymes, and such involved in a certain metabolic system, the mixture is reacted, and then a change occurred in the compound cocktail... Agent: Lahive & Cockfield, LLP

20070172836 - Methods for detecting nucleic acids using multiple signals: Disclosed is are methods for identifying a nucleic acid in a sample. In one example, the method includes: (a) contacting the nucleic acid in the sample with an oligonucleotide that is specific for the nucleic acid in the sample and that is labeled with at least a first fluorescent dye;... Agent: Richard J. Warburg Foley & Lardner LLP

20070172885 - Methods for drug discovery, disease treatment, and diagnosis using metabolomics: The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.... Agent: Lahive & Cockfield, LLP

20070172842 - Methods for isolating and identifying novel target-specific structuremers for use in the biological sciences: Described are methods for isolating and identifying structuremers that specifically associate with non-nucleic acid target molecules. Each such structuremer species preferably minimally comprises a nucleic acid mimic capable of hybridizing to a substantially complementary single-stranded nucleic acid molecule under stringent hybridization conditions. Structuremers may also include tags to facilitate separation... Agent: Biotechnology Law Group C/o Portfolioip

20070172877 - Methods for preventing cattle reproductive diseases: The present invention relates to methods for treating or preventing diseases or disorders in a pregnant cow and calf nursing a pregnant cow caused by infection by Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2, Bovine Herpes Virus Type-1 (BHV-1), Bovine Respiratory Syncytial Virus (BRSV), Parainfluenza Virus (PIV3), Campylobacter... Agent: Peter I. Bernstein Scully, Scott, Murphy & Presser, P. C.

20070172871 - Methods for profiling transcriptosomes: The present invention concerns a method for profiling variations in gene transcription (e.g., variable RNA processing) from complex and/or unknown genomic regions. Rather than screening EST or cDNA libraries for transcripts of interest, the method of the invention involves the reverse, i.e., using the genetic locus responsible for the gene... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070172858 - Methods for sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172867 - Methods for sequence determination: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172866 - Methods for sequence determination using depolymerizing agent: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172846 - Methods for the production and purification of adenoviral vectors: The present invention relates to compositions comprising and methods for producing adenovirus compositions wherein host cells are grown in a bioreactor and purified by size partitioning purification to provide purified adenovirus compositions.... Agent: Fulbright & Jaworski L.L.P.

20070172878 - Methods using novel chemiluminescent labels: Methods using chemiluminescent label compounds and chemiluminescent labeled conjugates are provided. The compounds comprise an acridan ring bearing an exocyclic ketene dithioacetal group and further contain a labeling substituent which permits attachment to compounds of interest. The novel chemiluminescent compounds and labeled conjugates are convenient to prepare, are highly stable,... Agent: Lumigen, Inc.

20070172873 - Molecular counting: The invention provides methods and compositions for counting molecules in a sample, wherein each molecule is labeled with a unique oligonucleotide tag. Such tags are amplified and identified rather than the molecules themselves; that is, the problem of counting molecules is converted into the problem of counting tags. In one... Agent: Bozicevic, Field & Francis LLP

20070172847 - Molecular signaling pathways triggered by rituximab: prognostic, diagnostic, and therapeutic uses: The present invention provides markers associated with activated molecular signaling pathways (example: p38 MAKP, NF-κB, ERK1/2, YY-1 and AKT) inhibited by rituximab in cancer cells as well as pathways activated by rituximab (such as death receptors, RKIP, PTEN) all of which are associated with the regulation of chemo and immunoresistance.... Agent: Townsend And Townsend And Crew, LLP

20070172835 - Multiplex detection of respiratory pathogens: The present invention is directed to methods, compositions and kits for multiplex detection of pathogens, such as respiratory pathogens.... Agent: Lawrence Livermore National Laboratory

20070172827 - Multiplex detection probes: The present invention comprises detection probes utilizing vesicles or soluble bodies to retain multiple mass tag molecules. The detection probes may be used to simultaneously assay a plurality of different biological samples, each comprising a plurality of analytes, by immobilizing the analytes from each of the samples on a surface... Agent: Knobbe Martens Olson & Bear LLP

20070172861 - Mutant polymerases: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172848 - Novel calpastatin (cast) alleles: Disclosed herein are novel alleles characterized by polymorphisms in the CAST gene. The alleles may be used to genetically type animals. In a preferred embodiment, the alleles may be used as markers for animal meat quality and/or growth. Methods for identifying such markers, and methods of screening animals to determine... Agent: Mckee, Voorhees & Sease, P.L.C

20070172850 - Novel chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070172881 - Novel essential fungal polynucleotides, polypeptides, and methods of use: The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.... Agent: Louis J. Wille Bristol-myers Squibb Company

20070172855 - Nucleic acid purification with a binding matrix: The present invention relates to methods, kits, and compositions for generating purified RNA samples and purified DNA samples. In particular, the present invention provides methods for generating a purified RNA or DNA sample from a sample containing both DNA and RNA molecules using a binding matrix that preferentially binds DNA... Agent: Medlen & Carroll, LLP

20070172829 - Oligonucleotides and methods for detecting borrelia burgdorferi: The present invention provides methods and compositions for determining the presence and/or amount of Borrelia burgdorferi nucleic acids in a test sample related to Lyme disease. In particular, substantially purified oligonucleotide primers and probes are described that can be used for qualitatively and quantitatively detecting Borrelia burgdorferi nucleic acid in... Agent: Foley & Lardner LLP

20070172832 - Phosphonate fluorescent dyes and conjugates: Reagents are provided for the introduction of phosphonate groups into fluorescent dyes. Methods are also provided for preparing dye conjugates.... Agent: Townsend And Townsend And Crew, LLP

20070172880 - Polynucleotide encoding a novel trp channel family member, trp-plik2, and splice variants thereof: The present invention provides novel polynucleotides encoding TRP-PLIK2 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of TRP-PLIK2 polypeptides, TRP-PLIK2b, TRP-PLIK2c, and TRP-PLIK2d, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention... Agent: Louis J. Wille Bristol-myers Squibb Company

20070172857 - Primer and method for detecting lymph node metastasis: The present invention relates to a primer and method for detecting lymph node metastasis of a cancer cell derived from a colon cancer by detecting a marker in a sample prepared from a lymph node obtained from a living body, wherein the marker is a mRNA or a fragment of... Agent: Sughrue Mion, PLLC

20070172841 - Probe/target stabilization with add-in oligo: The invention relates to analyzing a sample containing small RNAs. In exemplary embodiments, the sample is contacted with an array in the presence of an add-in oligo. In typical embodiments, probes on the array include regions that are complementary to small RNAs and regions that are complementary to the add-in... Agent: Agilent Technologies Inc.

20070172822 - Prokaryotic dna repair ligases: The present invention relates to the cloning and characterisation of a prokaryotic DNA repair ligase, which is shown to possess a range of activities that allow the ligation and repair of non-compatible DNA ends and double strand breaks (DSBs). The enzyme has a range of applications in the manipulation and... Agent: Klarquist Sparkman, LLP

20070172831 - Schizophrenia gene signatures and methods of using the same: Compositions and methods that are useful for the diagnosis and treatment of schizophrenia are provided. More specifically, “gene signatures” are described that are characteristic of schizophrenia in an individual. The specific classes of genes that can be identified from these signatures are useful in that they provide the basis for... Agent: Darby & Darby P.C.

20070172865 - Sequence determination in confined regions: A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.... Agent: Robert W Strozier, P.l.l.c

20070172834 - Stable metal/conductive polymer composite colloids and methods for making and using the same: Stable metal/conductive polymer composite colloids and methods for making the same are provided. The subject colloids find use in a variety of different applications, including analyte detection applications. Also provided are kits that include the subject colloids.... Agent: Bozicevic, Field & Francis LLP

20070172879 - Thermophilic dna polymerases from thermoactinomyces vulgaris: The present invention provides compositions comprising thermostable DNA polymerases derived from hyperthermophilic eubacteria. In particular, the present invention comprises thermostable DNA polymerases from the hyperthermophilic eubacterial species Thermoactinomyces vulgaris. The present invention also provides methods for utilizing naturally-occurring and non-naturally-occurring forms of T. vulgaris DNA polymerase in sequencing, reverse transcription,... Agent: Medlen & Carroll, LLP

20070172853 - Use of deletion polymorphisms to predict, prevent, and manage histoincompatibility: Disclosed herein are methods for predicting the immunocompatibility of two subjects that include determining the presence or absence of one or more deletion variants in the DNA sequence of a gene, where the deletion variant substantially prevents expression of the protein encoded by the gene.... Agent: Clark & Elbing LLP

20070172889 - Human zven polypeptides: The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The... Agent: Zymogenetics, Inc. Intellectual Property Department

20070172890 - Magnetic rotation to improve signal-over-background in biosensing: The invention provides a method and a device (10) for distinguishing a specific binding from a less specific binding between at least one magnetic nanoparticle (11) and a surface of another entity by applying a magnetic field and detecting a physical parameter relating to magnetic nanoparticle rotational or motional freedom... Agent: Philips Intellectual Property & Standards

20070172888 - Measuring troponin antibodies to assess cardiovascular risk: This invention relates to the field of myocardial disorders. It discloses that antibodies to a cardiac troponin found in a sample obtained from an individual can be used as a diagnostic marker, especially in the assessment of an individual's risk of developing a myocardial disorder. A method aiding in the... Agent: Roche Diagnostics Operations Inc.

20070172887 - Monoclonal antibody based biomarker discovery and development platform: A method or platform for monoclonal antibody based biomarker discovery is disclosed. The method according to the invention provides for the integration of analyte collection, hybridoma screening and nanovolume integrated mass spectrometry (NVIMS) to achieve a robust screening system that is capable, for example, of cutting 4-6 years off of... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20070172892 - Novel polypeptide esdn, polynucleotides encoding the polypeptide, and utility of the polypeptide: The invention discloses a useful and novel factor (polypeptide) which plays an important role for morbid vascular smooth muscle in restenosis after percutaneous transluminal coronany angioplasty (PTCA) and arterial sclerosis in the field of cardiovascular system.... Agent: Sughrue Mion, PLLC

20070172886 - Reaction module for biological analysis: The present invention relates to a reaction module for biological analysis comprising the injection of biological fluid and/or of reagent allowing a determined biological reaction comprising at least one means for controlling the quantity of biological fluid and/or of reagent injected.... Agent: Oliff & Berridge, PLC

20070172893 - Recombinant platelet collagen receptor glycoprotein vi and its pharmaceutical use: The invention relates to Glycoprotein VI (GPVI), its isolation, purification, and methods for recombinant production. Especially, the invention relates to the use of GPVI, preferably recombinant GPVI, in the treatment of disorders and pathological events correlated directly or indirectly to blood coagulation disorders such as thrombotic and cardiovascular diseases. The... Agent: Millen, White, Zelano & Branigan, P.C.

20070172895 - Cd86 and cd80 receptor competition assays: The present invention discloses a method for assaying the binding of L104EA29YIg to a receptor. The receptor is preferably CD86 or CD80. The present invention also discloses antibodies to be used in the assay, as well as hybridomas expressing the antibodies.... Agent: Louis J. Wille Bristol-myers Squibb Company

20070172894 - Methods for screening cells and antibodies: The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070172898 - Diagnostic test: A method of diagnosing intolerance by a subject to a specified substance which comprises incubating a leucocyte sample prepared from whole blood drawn from the subject with an extract of said substance and detecting whether or not PMNs in the sample have become activated.... Agent: Fulbright & Jaworski, LLP

20070172899 - Magnetic particle tagged reagents and techniques: Methods for separating, in a continuous, multizone fluid medium, cells, particles, or other molecules of interest (MOI) from associated or contaminating unwanted materials not of interest (MNOI). The invention involves forced movement of MOI into certain zones having properties which deter the entry of unwanted materials. Differential movement of MOI... Agent: Ralph T. Lilore

20070172902 - Biomarker for ovarian cancer: The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarker can be detected by SELDI mass spectrometry.... Agent: Edwards Angell Palmer & Dodge LLP

20070172900 - Diagnostic marker for cancer: The invention relates to the use of various proteins as diagnostic markers for cancerous diseases. In particular, the use of the annexin A3 protein is preferred. Preferably an increased regulation of annexin A3 is analysed in comparison to controls. The invention also relates to the use of active substances for... Agent: Nath & Associates

20070172901 - Method for the evaluation of the functional status of the growth factor receptor protein expressed in malignant tumors: A novel examination method for accurately evaluating the effectiveness of treatment with an anticancer drug for the administration of the anticancer drug targeting a tumor-associated factor receptor is provided. In order to evaluate the effectiveness of trastuzumab (Herceptin™) of an anticancer drug, it was found to be meaningful to examine... Agent: Jhk Law

20070172903 - Microfluidic device for cell separation and uses thereof: The invention features methods for separating cells from a sample (e.g., separating fetal red blood cells from maternal blood). The method begins with the introduction of a sample including cells into one or more microfluidic channels. In one embodiment, the device includes at least two processing steps. For example, a... Agent: Clark & Elbing LLP

20070172904 - Method for quantitative detection of biological toxins: The invention relates to analytical chemistry and to quantitative immunochemical analysis, in particular, to a method for immunochemical quantitative detection of various biological toxins by using biological microchips. A biological microchip comprises an ordered array of three-dimensional hydrogel cells on a solid support, which are produced by a method of... Agent: Ladas & Parry

20070172896 - Methods for cyclic nucleotide determination: The present invention relates in general to cellular analysis tools and more particularly to methods for detecting or determining cyclic nucleotide concentrations in samples.... Agent: Medlen & Carroll, LLP Suite 350

20070172897 - Methods and compositions for diagnosing ankylosing spondylitis using biomarkers: The invention provides a method for determining the efficacy of a TNFα inhibitor, such as a TNFα antibody, or an antigen-binding portion thereof, for treating ankylosing spondylitis (AS), using a collagen degradation biomarker and/or a synovitis biomarker.... Agent: Lahive & Cockfield, LLP

20070172905 - Method for screening process conditions of a chemical coupling reaction and kits therefor: The present invention relates to a method of screening the operating conditions of a coupling reaction of at least two functional groups, and in particular of catalysts that are useful in this coupling reaction, and also to kits suitable for allowing this method to be carried out. Applications: fundamental and... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070172906 - Latent protein c assays and their uses for diagnosis and/or prognosis in systemic inflammatory response syndromes: The present invention relates to methods and compositions for measuring latent protein C in test samples, particularly patient samples. The methods and compositions described are sensitive for latent protein C, relative to activated protein C.... Agent: Townsend And Townsend And Crew, LLP

20070172907 - Liver disease-related methods and systems: The invention provides diagnostic methods, kits, and systems, and related computer-readable media, which use multiple blood marker values, including serum and plasma marker values, to aid in the diagnosis of the status or progress of a liver disease in a patient. The invention also provides methods and systems, and related... Agent: John M. Paolino, Esq. Bayer Healthcare

20070172908 - Enteropathogenic e. coli is a separate genus pathogenic bacteria: An assay is provided which recognizes the absence of dehydrogenase in all pathogenic bacteria and its presence in nonpathogenic (conditionally pathogenic) bacteria creating the opportunity to separate and establish enteropathogenic Escherichia (EPE) in a pathogenic genus bacteria; genus Brilmanella. A method for diagnosing maladies of the bowel based on the... Agent: Flaster/greenberg P.C. 8 Penn Center

20070172909 - Non-ribosomal peptide synthetases and associated biosynthetic genes: The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus. The present invention further provides methods for generating novel compounds, such as antibiotics, from these synthetases and associated genes.... Agent: Wyeth C/o Darby & Darby, P.C.

20070172910 - Food freshness indicator and food storage systems same: A freshness indicator comprises a support structure that is substantially impermeable to fluids. A test device is engaged with the support structure and includes a pathogen detection composition. The pathogen detection composition provides a prescribed visual indication when in the presence of a prescribed type of pathogens and/or a by-product... Agent: David Odell Simmons

20070172911 - Biological sample processing composition and method: A method and composition are disclosed that are useful for processing biological samples. In one aspect, a biological sample such as a tissue section is treated using a histochemical technique and is contacted with a lipid compound during the process to enhance the definition of cellular and sub-cellular features that... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20070172913 - Production of a fermentation product: A process of separating suspended solids from a fermentation liquor by subjecting the liquor to a solids-liquid separation stage, wherein the fermentation liquor is produced in a fermentation process for the production of a fermentation product, in which the liquor has been subjected to a temperature of at least 50°... Agent: Ciba Specialty Chemicals Corporation Patent Department

20070172915 - Glycoprotein synthesis: Methods for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid into a protein and attaching one or more saccharide moieties to the unnatural amino acid. Another method involves incorporating an unnatural amino acid that includes a saccharide moiety into a... Agent: Quine Intellectual Property Law Group, P.C.

20070172914 - Protein concentrate and an aqueous stream containing water-soluble carbohydrates: Disclosed are process for contacting a protein containing material with one or more wet-mill streams. The protein content of the protein containing material is increased.... Agent: Fish & Richardson P.C.

20070172917 - Cytokine receptor zalpha11: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can... Agent: Zymogenetics, Inc. Intellectual Property Department

20070172920 - Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells: A chimeric LL2 monoclonal antibody is described in which the complementarity determining regions (CDRs) of the light and heavy chains of the murine LL2 anti-B-lymphoma, anti-leukemia cell monoclonal antibody has been recombinantly joined to the human kappa and IgG1 constant region domains, respectively, which retains the immunospecificity and B-cell lymphoma... Agent: Rossi, Kimms & Mcdowell LLP.

20070172918 - Non aggregating fluorescent proteins and methods for using the same: Nucleic acid compositions encoding non-aggregating chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The proteins of interest are polypeptides that are non-aggregating colored and/or fluorescent proteins, where the non-aggregating feature arises from the modulation of residues in the N-terminus of the protein and... Agent: Bozicevic, Field & Francis LLP

20070172916 - Novel bacillus 029cel cellulase: The present invention provides a novel cellulase nucleic acid sequence, designated 029cel, and the corresponding 029cel amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding 029cel, recombinant 029cel proteins and methods for producing the same.... Agent: Victoria L Boyd Genencor International Inc

20070172919 - Wdr36 gene alterations and glaucoma: Disclosed herein is the mapping of a new adult-onset primary open-angle glaucoma (POAG) locus on 5q22.1 (GLC1G) and identification of its defective gene. Mutation screening of 7 candidate genes from the GLC1G critical region identified the WDR36 (WD40-Repeat 36) gene. Methods of detection, prognosis and diagnosis of the presence or... Agent: Cantor Colburn, LLP

20070172921 - Secretion, transcription and sporulation genes in bacillus clausii: The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods for producing proteins in such host cells, such as members of the... Agent: Kamrin T. Macknight Genencor International, Inc.

20070172922 - Secretion, transcription and sporulation genes in bacillus clausii: The present invention relates to cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms having exogenous nucleic acid sequences introduced therein and methods for producing proteins in such host cells, such as members of the... Agent: Kamrin T. Macknight Genencor International, Inc.

20070172923 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070172924 - Increasing the stability of recombinant adult human apohemoglobin: The disclosure relates to recombinant adult human apohemoglobin (apo-rHb) in which the stability has been increased by replacement of an amino acid with a counterpart from another organism, such as a deep sea diving mammal. This mutated apo-rHb may be more stable and/or give higher production yields than unmutated adult... Agent: Baker Botts L.L.P. Patent Department

20070172925 - Ribonucleic acid compound and method of liquid-phase synthesis of oligonucleic acid compound: (wherein B represents adenine, guanine, cytosine or uracil or a modified form thereof; R21 represents aryl which may be substituted or a monocyclic or bicyclic heterocyclic group which may be substituted; R20 represents H or alkyl which may be substituted; and R1 represents a protecting group which can be removed... Agent: Darby & Darby P.C.

20070172929 - Cold-adapted influenza virus: The cold-adapted master strain A/Ann Arbor/6/60 7PI (H2N2) and progenitor wild type E2(3) viral strains have been deposited and their genomic sequences identified. Seven nucleotide differences were found between the sequences identified herein and the previously published sequences for cold-adapted A/Ann Arbor/6/60 genes. The cold-adapted live influenza virus of the... Agent: Johnathan Klein-evans

20070172927 - Immune complexes comprising proteins of human immunodeficiency virus type 2 (hiv-2), antibodies against proteins of hiv-2, methods and kits employing proteins of hiv-2, and immunogenic compositions comprising proteins of hiv-2: Four glycoproteins of apparent molecular weights 300,000, 140,000, 125,000, and 36,000 (gp300, gp140, gp125, and gp36) are detectable in human immunodeficiency virus type 2 (HIV-2) infected cells. The gp125 and gp36 are the external and transmembrane components, respectively, of the envelope glycoproteins of HIV-2 mature virions. The gp300, which is... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070172928 - Immunoglobulin chimeric monomer-dimer hybrids: The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion of an immunoglobulin constant region and a biologically active molecule, and said second polypeptide chain comprising at least a portion of... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070172926 - Methods and compositions for identifying and characterizing hepatitis c: The invention provides novel methods and compositions for amplifying portions of the HCV genome. The nucleic acid sequences set forth as SEQ ID NOS:1-64 derived from HCV cDNA and functional equivalents thereof, kits containing same, and methods employing same, are useful for the identification and characterization of HCV in biological... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070172930 - Process for the selection of hiv-1 subtype c isolates, selected hiv-1 subtype isolates, their genes and modifications and derivatives thereof: The invention provides a process for the selection of HIV-1 subtype (clade) C isolates, selected HIV-1 subtype C isolates, their genes and modifications and derivatives thereof for use in prophylactic and therapeutic vaccines to produce proteins and polypeptides for the purpose of eliciting protection against HIV infection or disease. The... Agent: Kilpatrick Stockton LLP

20070172931 - Process for producing saccharide oligomers: A process for preparing saccharide oligomers uses an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and has a solids concentration of at least about 70% by weight. The feed composition is heated to a temperature of at least about 40° C., and is contacted... Agent: Williams, Morgan & Amerson

20070172932 - L-glutamic acid-producing microorganism and a method for producing l-glutamic acid: A coryneform bacterium which has an L-glutamic acid-producing ability and grows at least at the same growth rate as a non-mutated strain or a wild-type strain and has intracellular α-ketoglutarate dehydrogenase activity which is less than half that of the non-mutated or wild-type strain, and is obtained by introducing a... Agent: Cermak & Kenealy LLP Acs LLC

20070172933 - Thermally stable amidases: The invention relates to novel amidases which can be isolated from thermophilic bacteria, in particular from thermophilic Actinomycetes, e.g. Pseudonocardia thermophila, in which the resultant amidases not only have a high temperature stability, but are also distinguished by the enantioselective reaction of a broad substrate spectrum.... Agent: Connolly Bove Lodge & Hutz, LLP

20070172934 - Method for the production of flavor-active terpenes: Disclosed is a method for producing flavor-active terpenes from terpene hydrocarbons. According to said method, a lyophilized mycel which is first rehydrated and is then mixed with the substrate is used preferably in a submerged culture in the framework of selective biotransformation with the aid of microorganisms. The inventive method,... Agent: Morris Manning Martin LLP

20070172935 - Tank bioleaching process: A method of operating a tank bioleaching process of a concentrate, which includes the step of supplying carbon in a non-gaseous form to microbial cells used in the process.... Agent: Brinks Hofer Gilson & Lione

20070172936 - Purified active hcv ns2/3 protease: A method for producing a refolded, inactive form of recombinantly produced NS2/3 protease which comprises the steps of: a) purifying the protease from inclusion bodies in the presence of a chaotropic agent; and b) refolding the purified protease by contacting it with a reducing agent and lauryldiethylamine oxide (LDAO) in... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20070172937 - Recombinant cells that highly express chromosomally-integrated heterologous genes: Recombinant host cells are obtained that comprise (A) a heterologous, polypeptide-encoding polynucleotide segment, stably integrated into a chromosome, which is under transcriptional control of an endogenous promoter and (B) a mutation that effects increased expression of the heterologous segment, resulting in enhanced production by the host cells of each polypeptide... Agent: Edwards Angell Palmer & Dodge LLP

20070172938 - Solid cellulosic culture medium and process for producing the same: The present invention relates to a solid medium containing as a medium-solidifying component a cellulose gel, in particular a cellulose gel which is a porous cellulose gel structure containing cellulose as the skeletal part and having a cellulose concentration of 0.01% or higher and a porosity of 50% or higher,... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070172939 - Real time electronic cell sensing system and applications for cell-based assays: The present invention includes devices, systems, and methods for assaying cells using cell-substrate impedance monitoring. In one aspect, the invention provides cell-substrate impedance monitoring devices that comprise electrode arrays on a nonconducting substrate, in which each of the arrays has an approximately uniform electrode resistance across the entire array. In... Agent: David R Preston & Associates Apc

20070172941 - Disposable vessels or tips having ultra-thin areas therein, and methods for manufacture of same: The invention discloses disposable polymeric vessels or tip products, having a thin area upon at least a portion of the vessel or tip, for use in medical and scientific laboratories. The thin area has a thickness of less than 100 microns. Examples of such products are test-tubes, microtubes and multiwell... Agent: Edward Langer C/o Shiboleth Yisraeli Roberts Zisman & Co.

20070172940 - Fabrication and packaging of suspended microchannel detectors: An apparatus for detecting an analyte in solution that has a suspended beam containing at least one microfluidic channel containing a capture ligand that bonds to or reacts with an analyte. The apparatus also includes at least one detector for measuring a change in the beam upon binding or reaction... Agent: Choate, Hall & Stewart LLP

20070172942 - Apparatus for producing tissue arrays: An apparatus for producing a tissue array, having at least one donor block (2) that comprises tissue (3) to be investigated, is described. A marked tissue section of the tissue (3) to be investigated is arranged on a specimen slide (22), a hollow needle (5) for removing a sample from... Agent: Hodgson Russ LLP The Guaranty Building

20070172943 - Devices and methods for culturing, preserving, transporting, storing, reconstituting and assaying cellular materials: Devices, systems and methods for preparing, packaging and using biological materials are disclosed. Biological materials such as cellular or subscellular materials can be introduced in one or more complete assembled devices and preserved within the devices by, for example, being cooled or frozen. Such assembled devices can allow easy transportation... Agent: Knobbe Martens Olson & Bear LLP

20070172944 - Cell culture tool: A cell culture tool includes a cell culture tray and a dish or insert tray that rests on the cell culture tray. The cell culture tray includes a substantially flat surface with more than one well, each well configured to contain a liquid volume and an outer wall surrounding the... Agent: Kevin J. Mcneely, Esq.

20070172945 - Bioreactor: The present invention concerns a plunging jet bioreactor (1) comprising a mechanism (4), (5) adapted in use to form culture fluid into a hollow flow stream and to introduce into the hollow of the flow stream an oxygen-containing gas. In some embodiments the mechanism comprises concentrically arranged outer (4) and... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20070172946 - Lineage specific cells and progenitor cells: A method for generating a culture that is purified or enriched in respect of cells of a selected lineage is described in which a selectable marker, which is differentially expressed in cells of the selected lineage compared with its expression in other cells, is introduced into a multipotential cell and... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070172947 - Methods and compositions for expanding t regulatory cells: The present invention provides methods and compositions for expanding Treg cells ex vivo or in vivo using one or more conjugates comprising a costimulatory moiety that stimulates at least one of three signals involved in Treg cell development and/or using dendritic cells pulsed with antigens and modified to display TGF-β,... Agent: Foley And Lardner LLP Suite 500

20070172948 - Double strand compositions comprising differentially modified strands for use in gene modulation: The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having a gapped motif and another strand having a gapped motif, a hemimer motif, a blockmer motif,... Agent: Woodcock Washburn LLP

20070172949 - Vectors and viral vectors, and packaging cell lines for propagating same: Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vectors may include one or more native... Agent: Hunton & Williams LLP Intellectual Property Department

20070172950 - Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use of gene transfer: Novel lipid-nucleic acid particulate complexes which are useful for in vitro or in vivo gene transfer are described. The particles can be formed using either detergent dialysis methods or methods which utilize organic solvents. Upon removal of a solubilizing component (i.e., detergent or an organic solvent) the lipid-nucleic acid complexes... Agent: Seed Intellectual Property Law Group PLLC

20070166730 - Magnetic resonance system and method to detect and confirm analytes: A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20070166774 - Functional immunoassay: Compositions, methods, and functional immunoassays for measuring functioning of organs, receptors, and biological processes in a subject are provided. Functional immunoassay combines pharmacokinetics of xenobiotics after administering one or more of the compositions to a subject by quantifying the xenobiotic in samples taken from the subject. The method provides a... Agent: Lawson & Weitzen, LLP

20070166801 - Compositions and methods for the treatment of influenza infection: The invention provides compositions of oligonucleotides targeted at influenza genes and at host animal genes involved in response to influenza infection. In some embodiments, the oligonucleotides are modified. In some embodiments, the compositions contain one, or more than one, oligonucleotide. The invention also provides methods and kits using the compositions... Agent: Wilson Sonsini Goodrich & Rosati

20070166694 - Composition and method to increase mammalian sperm function: A composition of matter for increasing the motility and/or percentage of intact acrosomes (PIA) in sperm is described. The composition includes, in combination, an amount of FAA and an amount of TIMP-2, wherein the amounts are effective to increase the motility, the PIA, or the motility and PIA of sperm... Agent: Dewitt Ross & Stevens S.c.

20070166696 - Adenovirus-transfected primary cells and methods of pathway mapping: A primary cell culture is transfected with a vector comprising a reporter gene operatively linked to a cis-element. Expression of a candidate regulatory protein is induced in the cell culture and its effects on the cis-element are assayed.... Agent: Ross J. Oehler Sanofi-aventis U.s. LLC

20070166698 - Assay method for drugs to treat atherosclerosis, cancer and alzheimer's disease: An assay to screen for potentially beneficial drugs against atherosclerosis, cancer and Alzheimer's disease, and their effectiveness in vitro. The assay is comprised of a system where LDL or cholesterol is given to various cells together with the drug being tested and then chromosome segregation and aneuploidy are detected using... Agent: Smith Hopen, Pa

20070166695 - Method for testing or screening for an enzyme of interest: The present invention relates to methods for testing or screening for an enzyme of interest.... Agent: Novozymes North America, Inc.

20070166697 - Synthesis and use of cross-linked hydrophilic hollow spheres for encapsulating hydrophilic cargo: Cross-linked hydrophilic nanocapsules and various compositions and methods for their preparation and use are provided.... Agent: Dechert LLP

20070166699 - Combination of anti-hpv-16 and 18 antibodies and uses thereof: The present invention relates to a combination of antibodies comprising (a) an anti-HPV-16 E7 antibody obtainable by (i) eliciting an in vivo humoral response against HPV-16 E7 protein or a fragment thereof in a goat; and (ii) affinity-purifying antibodies as obtained in the eliciting-step (i) and (b) an anti-HPV-18 E7... Agent: Foley And Lardner LLP Suite 500

20070166703 - Method of detecting pathogenic microorganism in real-time, using modified flow-type surface plasmon resonance biosensor: There is provided a method of detecting a pathogenic microorganism in real-time, using a modified flow-type surface plasmon resonance (SPR) biosensor, comprising the steps of: i) performing, in a batch-type, an immune reaction of a pathogenic microorganism and an antibody thereto; ii) selectively separating the pathogenic microorganism bound with the... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20070166701 - Methods for detecting flavivirus infection: The present invention encompasses isolated nucleic acids containing transcriptional units which encode a signal sequence of one flavivirus and an immunogenic flavivirus antigen of a second flavivirus. The invention further encompasses a nucleic acid and protein vaccine and the use of the vaccine to immunize a subject against flavivirus infection.... Agent: Klarquist Sparkman, LLP

20070166702 - Methods for predicting the efficacy or outcome of hcv therapy: The present invention relates to a novel method for predicting likeliness of the outcome or efficacy of an antiviral therapy against Hepatitis C Virus (HCV). This method is based on the detection of antibodies against the proteins NSta and or NS5a in a sample of a patient. This method can... Agent: Clark & Elbing LLP

20070166700 - Sensing biological analytes on a ferroelectric transducer: A method of detecting a biological analyte within a sample (12) is provided. The analyte is one that can be electrically charged or polarized in the presence of an electric field. The sample is place in proximity with a ferroelectric transducer (14). An electric field is established to polarize the... Agent: Jacobson Holman PLLC

20070166744 - Analytical method and instrument: Subjects of the invention are a method for determination of an analyte using a particular algorithm based on a mathematical model for transforming measurement data into a growth curve and an analytical instrument comprising a computing unit for more precise determination of an analyte.... Agent: Roche Molecular Systems Inc Patent Law Department

20070166736 - Collagen xxii, a novel human collagen and uses thereof: The invention provides isolated nucleic acids molecules, designated collagen XXII nucleic acid molecules, which encode a novel collagen. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing collagen XXII nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in... Agent: Fish & Richardson PC

20070166739 - Comparative genomic hybridization on encoded multiplex particles: Disclosed herein are methods and compositions for evaluating genomic content using encoded particles to evaluate multiple samples in parallel.... Agent: Fish & Richardson PC

20070166755 - Compositions and methods for genetic analysis of polycystic kidney disease: The subject invention relates to nucleic acid sequences for detection of mutations in a PKD-1 or PKD-2 gene, as well as biomarkers for ADPKD. The invention further relates to methods for diagnosing ADPKD in an individual, and kits for performing the methods of the invention. The invention also provides a... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070166750 - Compositions and methods for nucleic acid extraction from biological samples: Methods and compositions for extracting nucleic acids from a biological sample are provided. The extraction compositions contain a protease enzyme such as proteinase K at alkaline pH with little or no surfactant present. Extraction can be efficiently performed in 60 minutes or less at room temperature for certain mammalian tissue... Agent: Senniger Powers

20070166751 - Compositions and methods for nucleic acid extraction from biological samples: Methods and compositions for extracting nucleic acids from a biological sample are provided. The extraction compositions contain a protease enzyme such as proteinase K at alkaline pH with little or no surfactant present. Extraction can be efficiently performed in 60 minutes or less at room temperature for certain mammalian tissue... Agent: Senniger Powers

20070166752 - Compositions and methods for nucleic acid extraction from biological samples: Methods and compositions for extracting nucleic acids from a biological sample are provided. The extraction compositions contain a protease enzyme such as proteinase K at alkaline pH with little or no surfactant present. Extraction can be efficiently performed in 60 minutes or less at room temperature for certain mammalian tissue... Agent: Senniger Powers

20070166707 - Computer systems and methods for associating genes with traits using cross species data: A method for confirming the association of a query QTL or a query gene in the genome of a second species with a clinical trait T exhibited by the second species. A first QTL or a first gene in a first species that is linked to a trait T′ is... Agent: Jones Day

20070166712 - Cyp2s1 as target for diagnosis and therapy of skin diseases: This invention relates to a retinoic acid metabolizing cytochrome P450 2S1 (CYP2S1) and to uses of sequence specific nucleic acid, primers and antibodies, in, for example, assays for the analysis of CYP2S1 messenger RNA and/or protein expression in skin. The invention also relates to assays for detecting agents which modulate... Agent: Darby & Darby P.C.

20070166722 - Detection mycobacterium: The present invention provides a method for determining the presence of Mycobacterium avium subspecies paratuberculosis (MAP) in a sample. The method involves using a pair of oligonucleotide probes and detecting the presence or absence of fluorescence resonance energy transfer (FRET) between the donor fluorescent moiety of the first probe and... Agent: Faegre & Benson LLP Patent Docketing

20070166733 - Detection of pkc-iota as a biomarker for brain tumorigenesis: A method of detecting brain tumorigenesis in a subject, the method including the steps of (a) obtaining a sample from the brain of the human subject, (b) detecting quantitatively or semi-quantitatively in the sample a level of expression for PKC-iota and (c) comparing the expression level in (b) to a... Agent: Smith Hopen, Pa

20070166718 - Diagnostic and therapeutic use of mal2 gene and protein for neurodegenerative diseases: The present invention discloses the differential expression of the gene coding for MAL2 protein in specific brain regions of Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing or prognosticating Alzheimer's disease in a subject, or for determining whether a subject is at increased risk... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070166715 - Diagnostics and therapeutics for diseases associated with aminopeptidase-like 1 (npepl1): The invention provides a human NPEPL1 which is associated with the cardiovascular diseases, cancer, dermatological diseases, gastroenterological diseases, metabolic diseases, inflammation, hematological diseases, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer,... Agent: Banner & Witcoff, Ltd.

20070166734 - Double strand compositions comprising differentially modified strands for use in gene modulation: The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having an alternating motif and another strand having a hemimer motif, a blockmer motif, a fully modified... Agent: Woodcock Washburn LLP

20070166721 - Fluidic circuits, methods and apparatus for use of whole blood samples in colorimetric assays: When the quantification of an analyte is based on a color change detected by a change in the amount of light transmitted or reflected, undiluted samples often saturate the detection range of the assay. Thus, very often, the sample needs to be diluted for reliable quantification. Disclosed are systems and... Agent: Knobbe Martens Olson & Bear LLP

20070166753 - Gene detection assay for improving the likelihood of an effective response to a her2 antibody cancer therapy: The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing HER2, as determined by a gene amplification assay, with a HER2 antibody. Such method comprises administering a cancer-treating dose of the HER2 antibody, preferably in addition to chemotherapeutic agents, to a subject... Agent: Genentech, Inc.

20070166727 - Genetic analysis and authentication: This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other... Agent: Eric P. Mirabez

20070166728 - Genetic profile imaging and data-sharing device and methodology for socially relevant traits: The present invention generally relates to genetic profiling and genetic data-sharing and, more particularly, is concerned with a system and method for genetic profile imaging and for determining and sharing information about a person's socially relevant traits. The present invention provides a means by which a person can safely share... Agent: Fredric Abramson

20070166746 - Human cytokine receptor: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”... Agent: Zymogenetics, Inc. Intellectual Property Department

20070166748 - Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor: The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member... Agent: Dykema Gossett PLLC

20070166723 - Hybridization-triggered fluorescent detection of nucleic acids: Compositions and methods for fluorescent detection of nucleic acids are provided. The compositions can be detected by fluorescence when hybridized to a nucleic acid containing a target sequence, but are non-fluorescent in the non-hybridized state. Alternatively, the fluorescence properties of the compositions change in a detectable manner upon hybridization to... Agent: Townsend And Townsend And Crew, LLP

20070166704 - Identification of polynucleotides and polypeptide for predicting activity of compounds that interact with protein tyrosine kinases and/or protein tyrosine kinase pathways: The present invention describes polynucleotides and polypeptides that have been discovered to correlate to the relative intrinsic sensitivity or resistance of cells, e.g., colon cell lines, to treatment with compounds that interact with and inhibit src tyrosine kinases. These polynucleotides and polypeptides have been shown, through a weighted voting cross... Agent: Louis J. Wille Bristol-myers Squibb Company

20070166709 - Immuno-pcr method: An immunoassay utilizing the polymerase chain reaction to detect biological molecules in a sample. In one embodiment, the method employs a plurality of nucleic acid templates with varying annealing temperatures when annealed to a detectable probe.... Agent: Crowell & Moring LLP Intellectual Property Group

20070166754 - In vitro cell-based methods for biological validation and pharmacological screening of chemical entities and biologicals: This patent describes a novel in vitro cell-based method for biological validation and pharmacological screening of drugs, new chemical entities (NCEs) and biologics, which is predictive of in vivo testing for efficacy and adverse events in patients, as occurs in clinical trials. The same method can be used to create... Agent: Cheryl H Agris Phd

20070166711 - Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof: Polynucleotide and polypeptide sequences for HFE2A, as well as mutations associated with juvenile hemochromatosis, and methods of utilizing these for the screening and identification of agents for the treatment of diseases of iron metabolism, including small organic compounds, are disclosed along with methods of treating and/or ameliorating diseases of iron... Agent: Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein

20070166738 - Markers for breast cancer: Correlations between polymorphisms and breast cancer are provided. Methods of diagnosing, prognosing, and treating breast cancer are provided. Systems and kits for diagnosis, prognosis and treatment of breast cancer are provided. Methods of identifying breast cancer modulators are also described.... Agent: Quine Intellectual Property Law Group, P.C.

20070166729 - Method and reagent for sequencing: The present invention provides: a method for nucleic acid analysis including the steps of subjecting a reaction solution containing a sample nucleic acid to complementary strand synthesis with the sample nucleic acid as a template, reacting pyrophosphate produced in the complementary strand synthesis with 30 to 800 μM AMP in... Agent: Stanley P. Fisher Reed Smith LLP

20070166706 - Method for detecting biomolecules: The invention relates to a method for detecting biomolecules, particularly peptides, proteins, carbohydrates, glycoproteins, proteoglycans and/or nucleic acids by using a metal compound in the presence of at least one bifunctional agent.... Agent: Nath & Associates

20070166726 - Method for detecting radiation exposure: A method is disclosed for detecting exposure of organisms to biologically significant or hazardous amounts of ionizing radiation. The method uses nucleic acid microarray hybridization to evaluate biological effects, such as patterns of expression of genes after radiation exposure. Numerous genes are provided which have been found to be responsive... Agent: Klarquist Sparkman, LLP

20070166716 - Method for evaluating rnai activity and mirna activity: The present invention provides methods whereby an RNAi activity and a miRNA activity can be evaluated simply and conveniently. The RNAi activity or the miRNA activity is evaluated by supplying a target-expressing molecule, which is a polynucleotide containing at least a target sequence and an expression regulatory region regulating the... Agent: Foley And Lardner LLP Suite 500

20070166731 - Method of identifying hairpin dna probes by partial fold analysis: Methods of identifying molecular beacons in which a secondary structure prediction algorithm is employed to identify oligonucleotide sequences within a target gene having the requisite hairpin structure. Isolated oligonucleotides, molecular beacons prepared from those oligonucleotides, and their use are also disclosed.... Agent: Nixon Peabody LLP - Patent Group

20070166717 - Methods and materials for assessing prostate cancer therapies: Using microarray-based profiling of isogenic prostate cancer xenograft models, we found that a modest (2-5 fold) increase in androgen receptor (AR) mRNA was the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels... Agent: Venable LLP

20070166708 - Methods for detection and quantification of analytes in complex mixtures: The invention provides a diverse population of uniquely labeled probes, containing about thirty or more target specific nucleic acid probes each attached to a unique label bound to a nucleic acid. Also provided is a method of producing a population of uniquely labeled nucleic acid probes. The method consists of... Agent: Mcdermott, Will & Emery

20070166710 - Methods for inhibiting adipogenesis and for treating type 2 diabetes: The present invention relates to methods for inhibiting adieogenesis and methods for treating obesity, metabolic syndrome and non-insulin dependent diabetes mellitus by administering an agent that increases Foxa-2 or Fxr, or an agent that activates Fxr. The invention is further related to methods for identifying agents that increase Foxa-2 or... Agent: Hoffmann & Baron, LLP

20070166747 - Methods for measuring therapy resistance: The present invention concerns methods for measuring drug resistance by correlating genotypic information with phenotypic profiles. In one embodiment, a method for interpreting genotypic information is described wherein a genetic code is generated from a patient sample, a list of mutations known or suspect to play a role in the... Agent: Woodcock Washburn LLP

20070166714 - Methods for preparing gene chips and use thereof: The invention relates to methods and compositions for producing biochips as well as to the use of these biochips in diverse fields, from functional genomics to diagnosis, for example, particularly in research or in the medical field. The invention also relates to tools and methods for selecting polynucleotides that permit... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070166749 - Methods of analyzing chromosomal translocations using fluorescence in situ hybridization (fish): Probes and methods of using the probes to detect chromosomal rearrangements and/or deletions are provided. The methods utilize probes that are free of repeat sequences to provide greater selectivity and sensitivity; methods for producing such probes are also disclosed. The probe sets utilized in the detection methods are designed to... Agent: Townsend And Townsend And Crew, LLP

20070166735 - Methods of in vitro propagation and detection of infectious prion: Methods for the in vitro propagation of infectious prions (PrPSc) are provided. Follicular dendritic cells (FDCs) are cultured with B cells and infected with prions. Methods of detecting infectious prions (PrPSc) in an animal or human are also provided. Peripheral blood B cells are collected from an animal or human... Agent: Crompton, Seager & Tufte, LLC

20070166724 - Micrornas and related nucleic acids: Described herein are novel polynucleotides associated with disease. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of disease. Also described herein are methods that can be used to identify modulators of the disease-associated polynucleotides.... Agent: Rosetta-genomics C/o Psws

20070166705 - Modified nucleotides: The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O-Z wherein Z is any of —C(R′)2-O—R″,... Agent: Klauber & Jackson

20070166740 - Multiplexed analyses of test samples: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule.... Agent: Swanson & Bratschun L.L.C.

20070166741 - Multiplexed analyses of test samples: The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule.... Agent: Swanson & Bratschun L.L.C.

20070166725 - Multiplexed diagnostic platform for point-of care pathogen detection: The invention provides a system for high-throughput multiplex analysis of target samples. A sample and reagent delivery unit is operatively connected to a thermal cycler for amplification of target nucleic acids. Microspheres are hybridized to the resulting amplicons in the thermal cycler. A flow cytometer is operatively connected to the... Agent: John Lee Assistant Laboratory Counsel

20070166719 - Novel modular type ii restriction endonuclease, cspci, and the use of modular endonucleases for generating endonucleases with new specificities: A novel restriction endonuclease and methods of making the same are obtainable from either Citrobacter species 2144 (NEB#1398) or the recombinant stain Escherichia coli (NEB#1554) which cleaves at nt sequence 5′-CAANNNNNGTGG-3′ (SEQ ID NO:14) in double-stranded DNA molecules. The novel restriction endonuclease is a modular protein in which the specificity... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20070166732 - Novel nucleic acids and associated diagnostics: The present invention relates to methods of diagnosing spondylocostal dysostosis (SCD) disorders, such as Jarcho-Levin syndrome, in humans for use in genetic counseling and linkage analyses. Methods and compositions for measuring the presence or absence of a specific mutation to Mesp2 associated with Jarcho-Levin syndrome, alone or in combination with... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20070166742 - Nucleic acid ligand diagnostic biochip: A nucleic acid ligand “biochip” is disclosed, consisting of a solid support to which one or more specific nucleic acid ligands is attached in a spatially defined manner. Each nucleic acid ligand binds specifically and avidly to a particular target molecule contained within a test mixture, such as a bodily... Agent: Swanson & Bratschun L.L.C.

20070166756 - Polypeptides and polynucleotides encoding same: The invention provides polypeptides, designated herein as SECP polypeptides, as well as polynucleotides encoding SECP polypeptides, and antibodies that immunospecifically-bind to SECP polypeptide or polynucleotide, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which the SECP polypeptide, polynucleotide, and antibody are used in the detection,... Agent: Ivor R. Elrifi, Ph.d. Mintz, Levin, Cohn, Ferris,

20070166743 - Quantum dots and methods of use thereof: Quantum dots and methods of use thereof for labeling and analyzing polymers such as nucleic acid molecules are described herein.... Agent: Wolf Greenfield & Sacks, P.C.

20070166745 - Screening and use of reagents which block or activate intein splicing utilizing natural or homologous exteins: In accordance with the present invention, there are provided selection systems and methods for screening for agents that control splicing of inteins in their native host protein (extein) or in homologous exteins. Specifically, there are provided positive genetic selection systems for the screening of agents which inhibit or activate protein... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20070166720 - Small interfering rna libraries and methods of synthesis and use: In one aspect, the invention provides a random or semirandom siRNA (encoding) library. Another aspect of the invention pertains to methods for construction of random or semirandom siRNA (encoding) libraries. Another aspect of the invention is vector systems for use in constructing siRNA libraries and/or that can express single siRNAs... Agent: Leydig Voit & Mayer, Ltd

20070166737 - Survival motor neuron (smn) gene: a gene for spinal muscular atrophy: The present invention relates to the discovery of the human survival motor-neuron gene or SMD gene, which is a chromosome 5-SMA (Spinal Muscular Atrophy) determining gene. The present invention further relates to the nucleotide sequence encoding the SMN gene and corresponding amino acid sequence, a vector containing the gene encoding... Agent: Birch Stewart Kolasch & Birch

20070166713 - System and method for fully automated robotic-assisted image analysis for in vitro and in vivo genotoxicity testing: A system and method is provided for performing genotoxicity screening. The system and method utilize: (1) one or more computers; (2) a frame grabber connected to the one or more computers; (3) a camera connected to the frame grabber; (4) a microscope connected to the one or more computers; (5)... Agent: Darby & Darby P.C.

20070166769 - Bi-directionally cloned random cdna expression vector libraries, compositions and methods of use: The present invention provides random cDNA expression vector libraries, comprising expression vectors which comprise random cDNAs positioned in sense and antisense orientation, which are useful for the delivery and expression of a combination of genetic effector types to host cells. Methods for producing these libraries through bi-directional cloning of random... Agent: Bozicevic, Field & Francis LLP

20070166759 - Chemiluminescent compounds: The invention relates to chemiluminescent compounds of general formula: (I) wherein: either: R1 is a reactive group capable of reacting with an amine or thiol moiety; L1 is a hydrocarbon linker moiety comprising 2-12 carbon atoms, optionally substituted with hydroxy, halo, nitro or C1-C4 alkoxy; and R2is hydrogen, C1-C4 alkyl,... Agent: Gen Probe Incorporated

20070166758 - Diagnostic method for stroke: Stroke is diagnosed in a subject by determining the concentration of at least one polypeptide selected from Apo C-III, Serum Amyloid A, Apo C-I, Antithrombin III fragment and Apo A-I in a sample of body fluid taken from the subject.... Agent: Arent Fox PLLC

20070166760 - Ligand searching device, ligand searching method, program, and recording medium: The present invention is directed to serve ligand screening apparatuses, ligand screening methods, programs and recording medium for studying the binding analysis between a receptor including an induced-fit type receptor and a ligand. First, analysis and calculation of normal mode are conducted, and then fluctuation of dihedral angle of main... Agent: Foley And Lardner LLP Suite 500

20070166766 - Method and apparatus for mass spectrometric immunoassay analysis of specific biological fluid proteins: Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins and their variants that are present in complex biological fluids or extracts. Protein and variant levels can be determined using quantitative methods in which the protein/variant signals are normalized to signals of internal reference standard... Agent: Snell & Wilmer L.L.P. (main)

20070166767 - Method and apparatus for mass spectrometric immunoassay analysis of specific biological fluid proteins: Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins and their variants that are present in complex biological fluids or extracts. Protein and variant levels can be determined using quantitative methods in which the protein/variant signals are normalized to signals of internal reference standard... Agent: Snell & Wilmer L.L.P. (main)

20070166768 - Method for predicting sepsis or an acute infectious inflammatory response: The present invention in one embodiment is an early detection marker for chronic or acute inflammatory-associated diseases. Chronic diseases may include atherosclerosis, Alzheimer's disease, asthma, rheumatoid arthritis, osteoarthritis, and inflammatory diseases of the bowel such as Crohn's disease, Ulcerative colitis, Irritable bowel syndrome and Inflammatory bowel disease. Acute diseases may... Agent: Dunlap, Codding & Rogers P.C.

20070166762 - Method of compensation of dose-response curve of an assay for sensitivity to perturbing variables: The present invention provides assays and methods of compensating for changes in the dose-response curve of an assay where such changes are due to variations in a perturbing variable such as, but not limited to temperature. This is achieved by a two-step method, the first step of which involves measurements... Agent: Ralph A. Dowell Of Dowell & Dowell P.C.

20070166761 - Plasmon fluorescence augmentation for chemical and biological testing apparatus: The sensitivity and durability of fluorescent assays may be increased through structures and methods using plasmon fluorescence augmentation and sealing of the structure against degradation by reagents used in the assay. The resulting structures make practical extremely sensitive fluorescent assays for DNA and other biological analytes.... Agent: William S Ramsey, Esq

20070166765 - Protein isoforms and uses thereof: There is provided a method for screening for or, diagnosis or prognosis of a neurological disorder in a subject, for determining the stage or severity of such a neurological disorder in a subject, for identifying a subject at risk of developing such a neurological disorder, or for monitoring the effect... Agent: Klauber & Jackson

20070166764 - Reagents for the detection of phosphorylated atr kinase (ser 428/ser 2317) and uses thereof: The invention discloses two novel phosphorylation sites in human ATR kinase, serine 428 (Ser428) and serine 2317 (Ser2317) respectively, and provides reagents, including antibodies and AQUA peptides, that selectively bind to and/or detect ATR only when phosphorylated at one or more of these respective sites, but do not bind to... Agent: James Gregory Cullem, Esq. Intellectual Property Counsel

20070166757 - Relaxin as an independent risk factor predicting mortality: Disclosed are methods of characterising life expectancy of human individuals on the basis of measured relaxin levels. In one aspect of the invention the human individuals are end-stage-kidney-disease patients.... Agent: Jeffrey M. Greenman

20070166763 - Surface plasmon resonance sensors and method for detecting samples using the same: Disclosed is an optical sensing device including a source unit providing a beam of light with continuously modulated phase retardation between p- and s-polarization components of the light by employing a LCM; a reference unit receiving a first part of the light to provide a reference signal; a SPR sensing... Agent: Darby & Darby P.C.

20070166771 - Miniaturized cell array methods and apparatus for cell-based screening: The present invention describes methods and cassettes for cell-based toxin detection and organ localization. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or depression in the matrix forms a domain individually addressable by microfluidic... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070166770 - Novel immunocytostaining methods for enhanced dye ratio discrimination in rare event detection: A method is provided for preparing a sample containing potential cells of interest and of using a laser of a laser based system for novel excitation and emission collection, and data usage including use of obtained data for direct and ratio based measurements. The prepared sample is configured to emit... Agent: Mark S. Svat, Esq. Fay, Sharpe, Fagan, Minnich &mckee, LLP

20070166773 - Compositions and methods for early pregnancy diagnosis: Pregnancy-associated glycoproteins (PAGs) are structurally related to the pepsins, thought to be restricted to the hoofed (ungulate) mammals and characterized by being expressed specifically in the outer epithelial cell layer (chorion/trophectoderm) of the placenta. By cloning expressed genes from ovine and bovine placental cDNA libraries, the inventors estimate that cattle,... Agent: Fulbright & Jaworski L.L.P.

20070166775 - Diagnosis and treatment for immunoglobulin e (ige) implicated disorders: Human saliva is used as a non-invasive source instead of invasive blood serum plasma for detection and assay of endogenously present proteins; nerve growth factor (NGF), myoglobin, Insulin, adenosine deaminiase (ADA), including immunoglobulin E (IgE). It was discovered that people having high levels of IgE, show high levels in comparison... Agent: John R. Casperson

20070166776 - Immunoassay and kit for an early and simultaneous detection of biochemical markers in a patient's sample: The present invention comprises an immunochemical assay for determination of at least two antigens in a sample. The immunochemical assay comprises contacting a sample from a patient with a carrier molecule that contains at least two capture antibodies, each of which specifically binds to a binding moiety of an antigen... Agent: Alleman Hall Mccoy Russell & Tuttle LLP

20070166772 - Methods for selecting compounds using antibodies with activity as antagonist, antagonist or allosteric modulators: The present invention relates to compositions and methods for screening, identifying, or selecting active compounds against a target protein using peptides derived from said target protein's active site(s) and functional antibodies active on said target protein active site(s). The invention also relates to the use of these peptides and functional... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070166777 - Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity: This invention relates to methods for determining the activity of Lp-PLA2 in at least one sample from an animal. The invention also relates to methods for determining the inhibition of Lp-PLA2 activity in samples from animals that are administered an Lp-PLA2 inhibitor.... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20070166779 - Processing of slpi by chymase: It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a treatment of a chymase-associated disease in a... Agent: Philip S. Johnson Johnson & Johnson

20070166778 - Substrates and methods for assaying deubiquitinating enzymes: The invention relates to substrates and methods suitable for assaying deubiquitinating enzyme activity, and in particular for screening inhibitors of enzymes involved in removal of mono or poly-ubiquitin chains from a target protein as well as inhibitors of ubiquitin precursors. Such inhibitors may have utility in the treatment of disease... Agent: Stites & Harbison PLLC

20070166781 - Method for assessing the virulence of pathogens and uses thereof: The present invention relates to a method of assessing the virulence of a pathogen or a toxin to a host organism. The present invention further relates to a method to identify a composition that reduces the virulence of a pathogen or toxin to a host organism. The invention also relates... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070166780 - Method for rapid detection and evaluation of cultured cell growth: Provided is a method and system for the rapid and accurate detection of growth and metabolism of a cellular microorganism in a population of microorganisms in a non-liquid, culture medium. Further provided is a gelled culture medium containing a non-toxic, water-soluble, phosphorescent compound which measures oxygen content (partial pressure) of... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070166782 - Biosynthesis of isopentenyl pyrophosphate: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the... Agent: Bozicevic, Field & Francis LLP

20070166783 - Synthesis of core sugar chain structure of aspargine-linked glycoprotein: It is intended to chemically synthesize the trisaccharide moiety at the reducing end in the core sugar chain structure of an asparagine-linked glycoprotein. By using a highly inexpensive natural polysaccharide having a mannoseβ-1,4-bond as the starting material, a β-1,4-glycoside bond of mannose is formed.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070166784 - Combination approaches for generating immune responses: The present invention relates to methods, polynucleotides, and polypeptides encoding immunogenic HIV polypeptides derived from different strains within an HIV subtype and/or immunogenic HIV polypeptides from different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are described. The combination approaches described herein have been... Agent: Robins & Pasternak

20070166790 - Derivatives of magainin and methods of production thereof: e

20070166791 - Expanding the eukaryotic genetic code: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic... Agent: Quine Intellectual Property Law Group, P.C.

20070166789 - Human cyclooxygenase-3 enzyme and uses thereof: The present invention provides nucleic acid and polypeptide sequences describing a novel isozyme of the cyclooxygenase enzyme, herein named as human cyclooxygenase-3. The isolated nucleic acid or polypeptide molecule of the invention can be used in detection assays, gene therapy, and screening assays.... Agent: Philip S. Johnson Johnson & Johnson

20070166793 - Hyaluronan synthase genes and expression thereof in bacillus hosts: The present invention relates to a recombinant Bacillus host cell containing a recombinant vector including a nucleic acid segment having a coding region segment encoding enzymatically active hyaluronan synthase (HAS). The recombinant Bacillus host cell is utilized in a method for producing hyaluronic acid (HA).... Agent: Dunlap, Codding & Rogers P.C.

20070166792 - Increasing hemoglobin and other heme protein production in bacteria by co-expression of heme transport genes: The present disclosure relates to methods for increasing heme uptake in a Gram-negative bacterium comprising expressing at least one transgenic heme transport gene in the bacterium. The present disclosure also relates to heme protein production cells comprising at least one transgenic heme transport gene and a heme protein gene and... Agent: Baker Botts L.L.P. Patent Department

20070166786 - Method of gene encoding a 4,5-dihydroxy-2-cyclopenten-1-one (dhcp) efflux protein promoting resistance to dhcp: The invention relates to a gene, dep, which confers resistance to the antibacterial activity of 4,5-dihydroxy-2-cyclopenten-1-one (DHCP). The invention further relates to the putative protein encoded by dep, which is a hydrophobic, transmembrane efflux protein specific for DHCP. The invention further relates to plasmids containing the dep gene, and to... Agent: Ip Group Of Dla Piper US LLP

20070166788 - Methods for production of receptor and ligand isoforms: Provided are methods for production of cell surface receptor (CSR) and ligand isoforms. In particular, isoform fusions that a precursor sequence for secretion, processing and intracellular trafficking are provided. Nucleic acid molecules encoding the fusions are expressed in a host cell and the encoded and partially or completely processed encoded... Agent: Morrison & Foerster LLP

20070166787 - Modulators of regulatory proteins: A modulator of regulatory cellular events occurring intracellularly which are mediated by regulatory proteins containing a ‘death domain’ motif is provided. The ‘death domain’ is a regulatory portion of the regulatory proteins, and the modulator is capable of interacting with one or more ‘death domain’ motifs contained in the regulatory... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070166785 - Recombinant calf-chymosin and a process for producing the same: The present invention relates to a recombinant calf-Chymosin protein as set forth in SEQ ID No. 1; a recombinant calf-Chymosin gene as set forth in SEQ ID No. 2 encoding the protein comprising amino acid sequence of SEQ ID NO. 1; an E. coli comprising the recombinant chymosin gene of... Agent: Foley And Lardner LLP Suite 500

20070166794 - Cytokine zalpha11 ligand fusion proteins: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller... Agent: Zymogenetics, Inc. Intellectual Property Department

20070166795 - Cytokine-like proteins: A full-length cDNA corresponding to an EST (AA418955), which does not show any homology to other proteins in the database but has a weak homology to G-CSF, has been successfully isolated by synthesizing primers based on the EST sequence, and effecting PCR-cloning from a human fetal spleen library. Sequencing of... Agent: Fish & Richardson P.C.

20070166796 - Il-21 antagonists: The polypeptides, and the polynucleotides encoding for them, described herein are IL-21 antagonists that bind with specificity and exhibit an EC50 that is not detectable in receptor binding studies. These molecules have mutations in the D helix of the IL-21 molecule, and can be used to inhibit the activity of... Agent: Zymogenetics, Inc. Intellectual Property Department

20070166797 - Devices and solutions for prevention of sexually transmitted diseases: Provided herein are antiviral compounds and methods of culturing microalgae to produce polysaccharides. Included in the invention are methods of producing novel polysaccharides with high antiviral avtivity. Also provided are methods of using polysaccharides for applications such as preventing or treating viral infections and providing prophylaxis and treatment for sexually... Agent: Solazyme, Inc.

20070166798 - Isolating chondroitin sulfate: A method of isolating chondroitin sulfate product from a feedstock comprising connective tissue.... Agent: Cargill Incorporated

20070166799 - Method for producing purine nucleonside by fermentation: A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated repressor of purine nucleotide biosynthesis encoded by purR, a... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070166800 - Immunogenic substances comprising a polyinosinic acid-polycytidilic acid based adjuvant: The present invention provides a polynucleotide adjuvant composition and methods of use in eliciting an immune response. The present invention also provides an immunogenic composition comprising the polynucleotide adjuvant composition together with other immunogenic compositions such as an antigen (e.g., as in a vaccine). The present invention further contemplates methods... Agent: Bozicevic, Field & Francis LLP

20070166802 - West nile vaccine: The present invention provides a safe and effective vaccine composition against West Nile virus disease. An immunogenically active component of West Nile virus or plasmid DNA, an adjuvant such as a metabolizable oil, and a pharmacologically acceptable carrier are formulated into an immunizing vaccine. The invention also provides a method... Agent: Wyeth Patent Law Group

20070166804 - Alpha-agarase and process for producing the same: A polypeptide having an α-agarase activity, a gene encoding the polypeptide, a method for producing the polypeptide by genetic engineering and a method for producing an agarooligosaccharide using the polypeptide.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070166803 - Staphylococcus aureus strain cyl1892: This disclosure presents embodiments of novel strains of Staphylococcus aureus that through genetic engineering produce type 5 capsular polysaccharide at greater levels than Staphylococcus aureus strain Reynolds.... Agent: Williams & Anderson PLC

20070166805 - Use of gr2 proteins to modify cellulosic materials and to enhance enzymatic and chemical modification of cellulose: This invention concerns methods of use for a class of proteins heretofore known as “grass pollen group-⅔ allergens” to modify the properties of cellulose-based materials, changing their mechanical properties, improving their accessibility to agents that chemically modify cellulose structure (such as cellulytic enzymes and chemical reagents), and altering binding of... Agent: Mckee, Voorhees & Sease, P.L.C Attn: Pennsylvania State University

20070166807 - Method for producing aromatic l-amino acid using bacterium belonging to the genus methylophilus: The present invention provides a method for producing an L-amino acid using a bacterium belonging to the genus Methylophilus which has been modified to enhance expression of genes involved in the efflux of aromatic L-amino acids, particularly the yddG, yddL, yddK, and yddJ genes from Escherichia coli.... Agent: Cermak & Kenealy LLP Acs LLC

20070166806 - Process for making amino acids: e

20070166808 - Methods of preparing activated polymers having alpha nitrogen groups: Methods for preparing substantially non-antigenic polymers having lone electron pair-containing moieties in high purity are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also... Agent: Lucas & Mercanti, LLP

20070166809 - Processes for the preparations of optically active cyclopentenones and cyclopentenones prepared therefrom: t

20070166811 - Deracemisation of amines: Methods are described for the deracemisation or chiral inversion of chiral amines by enzymatic treatment, such as by a stereoselective enzymatic conversion and either a non-selective or partially selective chemical or enzymatic conversion, simultaneously or sequentially. Also described are methods for selecting a suitable enzyme, particularly a suitable amine oxidase,... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B475

20070166810 - Methods and compositions for detecting enzymatic activity: This invention relates to methods and compositions useful in detecting enzymatic activity. Also featured are methods for diagnosing enzyme deficiencies such as metabolic disorders.... Agent: Fish & Richardson PC

20070166812 - Gamma subunit of cytokine responsive lkb-alpha kinase complex: The present invention provides a novel essential regulatory subunit of the IκB kinase (IKK) complex, IKK-γ. The isolated IKK-γ subunit of the invention has substantially the same amino acid sequence as SEQ ID NO: 2 shown in FIG. 2.... Agent: Medlen & Carroll, LLP Suite 350

20070166813 - Gaucher disease drugs and methods of identifying same: A method of identifying a compound capable of correcting an impaired enzymatic activity of a mutant glucocerebrosidase molecule, the method comprising: (a) obtaining a first set of structure coordinates, the first set of structure coordinates defining a 3D structure of a glucocerebrosidase molecule capable of displaying normal enzymatic activity or... Agent: Martin Moynihan Prtsi Inc

20070166814 - Synthesis of intermediates for the preparation of pramipexol: wherein R1 is straight or branched C1-C6 alkyl, optionally substituted with phenyl; the asterisk * and R defined above), with a lipase from Candida antarctica, under conditions effective to obtain a mixture comprising an acid of formula (I), as the individual (R) enantiomer, and an ester of formula (II), as... Agent: Griffin & Szipl, PC

20070166815 - Method for manufacturing protein chip substrate using plasma and protein chip substrate manufactured by the method: Disclosed herein are a protein chip substrate and a method for manufacturing the protein chip substrate. The method includes deposition of plasma polymerized ethylenediamine (PPEDA) having an amine group on plasma polymerized cyclohexnane (PPCHex) by inductively coupled plasma-chemical vapor deposition (ICP-CVD), thereby preventing non-specific adsorption of proteins on a slide... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070166816 - Assay device that analyzes the absorption, metabolism, permeability and/or toxicity of a candidate compound: This invention provides device for co-culturing at least two different cell types in a two-dimensional configuration, methods of patterning at least two different cell types in a two-dimensional co-culture configuration, and uses of these devices and methods for analyzing an effect of candidate compound on such cellular cocultures. Also provided... Agent: Kenyon & Kenyon LLP

20070166817 - System and method for applying reduced pressure to cell culture: A method and system for culturing cells, having a substantially airtight enclosure configured to culture cells. The method and system also have a first conduit configured to provide a reduced pressure to the substantially airtight enclosure and a second conduit configured to provide a culture media to the substantially airtight... Agent: Kinetic Concepts, Inc. Legal Department Intellectual Property

20070166818 - Device and method for uniformly inoculating a substrate having three-dimensional surfaces: An apparatus and method for inoculating a biological substrate with cells include provision for rotating a container in which the substrate and a cell suspension are received about first and second axes of rotation. The apparatus comprises said container, first drive means for rotatably supporting the container about the first... Agent: Millen, White, Zelano & Branigan, P.C.

20070166819 - Device for culturing and transporting cells: A disposable device is provided for culturing and/or packaging and transporting ready-to-use viable cells cultured on membranes, gels or micro porous substrata. The device includes a housing base defining an interior for culturing cells. The membrane to be used for culturing the cells is placed inside the housing base and... Agent: Vinson & Elkins, L.L.P.

20070166820 - Alphavirus replicons and helper constructs: The present invention provides a recombinant nucleic acid comprising: a first nucleic acid sequence encoding a 5′ alphavirus replication recognition sequence; at least one second nucleic acid sequence encoding an alphavirus nonstructural protein; at least one alphavirus subgenomic promoter; at least one IRES element; at least one heterologous nucleic acid;... Agent: Myers Bigel Sibley & Sajovec

20070166822 - Device for trapping extraneous gas: A device for trapping extraneous gas or bubbles is disclosed. The device is defined as having a gas collection area in a tapered neck portion such that when used as a cell culturing apparatus, extraneous gas or bubbles are trapped and isolated from the cell growth areas where cells or... Agent: Corning Incorporated

20070166821 - Serum production system: Bovine serum compositions having controlled bovine serum characteristics and a method of producing such bovine serum compositions having such controlled serum characteristics from the whole blood of an offspring of a female bovine mammal.... Agent: Cr Miles, P.C. Craig R. Miles

20070166823 - Methods for detecting parvovirous infections: The present invention provides a method for diagnosing a subject suffering a pathological condition characterized by parvovirus infection by detecting the presence of IgE anti-Parvovirus B 19 antibodies.... Agent: Scully, Scott, Murphy & Presser, P.C.

20070166824 - Manipulation of non-terminally differentiated cells using the notch pathway: The present invention is directed to methods for the expansion of non-terminally differentiated cells (“precursor cells”) using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or... Agent: Jones Day

20070166825 - Method of amplifying hematopoietic stem cell and hematopoietic progenitor cell: The present invention provides useful means in an expansion culture system for a hematopoietic cell (hematopoietic stem cell, hematopoietic progenitor cell). Specifically, the present invention provides a composition for expanding a hematopoietic cell (hematopoietic stem cell, hematopoietic progenitor cell) containing recombinant human serum albumin; a serum-free medium for expanding a... Agent: Leydig Voit & Mayer, Ltd

20070160974 - Human embryonic stem cell clones: The present invention provides methods for isolating individual viable stem cells from a stem cell line, methods for deriving one or more clones from a stem cell line, individual viable cells and clones derived from stem cell lines by the methods disclosed, methods for producing differentiated cells from the individual... Agent: Townsend And Townsend And Crew, LLP

20070160973 - Method to determine state of a cell exchanging metabolites with a fluid medium by analyzing the metabolites in the fluid medium: The present invention relates to a method for determining the ideal time for and outcome of reproductive health procedures including in vitro fertilization by establishing a correlation between the successful outcome of said procedure and the spectra of a body fluid obtained using a chosen analytical modality for a population... Agent: Bereskin And Parr

20070161006 - Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to infection and asthma: A gene related to a susceptibility of infection and asthma—the Protein-Tyrosine Phosphatase Receptor-type Delta (PTPRD) gene—a method of detecting the asthma-associated gene, a method of predicting the occurrence of asthma, a method of identifying asthma-associated alleles in PTPRD gene, a method of screening PTPRD for drugs useful in the treatment... Agent: Baker & Mckenzie LLP

20070160977 - Method for detecting molecules or chemical reactions by determining variation of conductance: The present invention relates to a detection method for detecting molecules and/or chemical reactions, whereby target molecules are attached to a series of electrodes, that the series of electrodes with molecules are subjected to assay said molecules or other molecules, whereupon the variation of conductance is determined.... Agent: Gauthier & Connors, LLP

20070160975 - Method for the identification of drugs to treat stroke at delayed timepoints: A method of in vitro screening for compounds for treating strokes at delayed timepoints of administration following the onset of stroke. In a first aspect the method includes the step of contacting neurons with azide/deoxyglucose to induce ischemia, contacting with a compound of interest at a later timepoint and assessing... Agent: Smith Hopen, Pa

20070160976 - Novel cellular function regulating agent produced by a chondrocyte capable of hypertrophication: The present invention provides an agent obtainable by culturing a chondrocyte capable of hypertrophication in a differentiation agent producing medium, wherein the differentiation agent producing medium comprises at least one conventional osteoblast differentiation component selected from the group consisting of glucocorticoid, β-glycerophosphate and ascorbic acid. The differentiation agent producing medium... Agent: Seed Intellectual Property Law Group PLLC

20070160982 - Development of influenza a antivirals: The present invention includes compositions, methods and systems to isolate and characterize novel antiviral agents by contacting the antiviral agent with the F2F3 zinc fingers of a CPSF30 protein and an Influenza A NS1A protein; and determining whether the binding between the CPSF30 protein and the Influenza A NS1A protein... Agent: Chalker Flores, LLP

20070160983 - Materials and methods for detection of enterovirus and norovirus: The invention provides polynucleotides and methods for detecting and quantifying RNA viruses, such as enteroviruses and noroviruses. In one aspect, the invention provides amplification primers and labeled molecular beacons for amplification of viral nucleic acid sequences. In another aspect, the invention provides a synthetic RNA internal control. In another aspect,... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070160979 - Method and device for the characterization of interactions between different species: A device detects interactions between species in liquid and species on a solid support. It includes a solid support (11), a mechanism (16) for temporarily reducing the amount of a liquid to which the support is exposed, a detector (12) capable of detecting an interaction between species attached to the... Agent: Young & Thompson

20070160978 - Method for seriological diagnosis and determination of immunisation status, comprising various controls: The invention relates to a method for serological diagnosis by means of indirect immunofluorescence, including the systematic control of the presence of rhumatoid factors and anti-nuclear antibodies in the serum of a patient, and the control of the presence and reactivity of the secondary detection antibodies anti IgM and anti... Agent: Dennison, Schultz & Macdonald

20070160984 - Multiple-property composite beads and preparation and use thereof: This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a bead, which bead comprises: a) a magnetizable substance; and b) an electrically conductive substance or an optical labeling substance. Methods and kits for isolating, detecting and... Agent: Morrison & Foerster LLP

20070160980 - Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina): This invention relates to compounds, compositions, and methods useful for modulating gene expression using short interfering nucleic acid (siNA) molecules. In particular, the instant invention features small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070160981 - Viral protease: An isolated polypeptide comprising a sequence that includes X−5-X−4-X−3-X−2-X−1-X+1, wherein X−5 is Arg, Ala, Ser, or Glu; X−4 is Leu; X−3 is Lys, Ala, Gln, or Asn; X−2 is Gly or Ala; X−1 is Gly; and X+1 is Ala, Gly, Asn, Val, or Lys; and the polypeptide, upon contact with... Agent: Fish & Richardson PC

20070160988 - Comparative genomic hybridization: The present invention relates to a method of comparing at least one chromosome or part thereof from a cell with a first karyotype with the corresponding chromosome or part thereof from a cell with a second karyotype. The method includes the steps of: (a) amplifying DNA from an isolated chromosome... Agent: Birch Stewart Kolasch & Birch

20070161034 - Compositions and methods for the therapy and diagnosis of colon cancer: Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein,... Agent: Seed Intellectual Property Law Group PLLC

20070161011 - Compositions for detection of a target nucleic acid sequence: The invention relates to compositions for generating a signal indicative of the presence of a target nucleic acid in a sample, where the compositions include a probe having a 5′ region and a 3′ flap and a P. furiosus polymerase having 3′ exonuclease activity.... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070161005 - Culturing circular ssdna viruses for the production of vaccines: The present invention relates to the use of interferon in the in vitro cultivation of animal circular ssDNA virus such as Porcine Circovirus 2 or human TT virus in an animal cell line. Increased titres of animal circular ssDNA virus are obtained by addition of interferons or agents which ensure... Agent: Clark & Elbing LLP

20070161013 - Cystic fibrosis transmembrane conductance regulator gene mutations: The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. The mutations include duplication of exons including duplication of exons 6b through 10. Methods of identifying if an individual contains the exons 6b through 10 duplication are provided as... Agent: Foley & Lardner LLP

20070160989 - Detection of histone modification in cell-free nucleosomes: This invention relates to the diagnosis of disease conditions, such as cancer and autoimmune disease, by the analysis of cell-free nucleosomes in samples from individuals. Methods of the invention may include contacting cell-free nucleosomes from a biological fluid sample obtained from the individual with an antibody that binds specifically with... Agent: Nixon & Vanderhye, PC

20070161015 - Detection of nucleic acids from whole blood: Methods of detecting one or more nucleic acids from whole blood or plasma are provided. The nucleic acids are captured on a solid support and detected. Compositions, kits, and systems related to the methods are also described.... Agent: Quine Intellectual Property Law Group, P.C.

20070161020 - Detection of nucleic acids through amplification of surrogate nucleic acids: Methods for detecting and optionally quantitating one or more target nucleic acids are provided, in which a surrogate nucleic acid is captured to each target nucleic acid, amplified, and detected. Compositions, kit, and systems related to the methods are also described.... Agent: Quine Intellectual Property Law Group, P.C.

20070160998 - Device for analyzing an interaction between target and probe molecules: The present invention relates to elongated hollow tubular body for analysing an interaction between target and probe molecules, comprising a support with through going channels enabling flow through of liquids arranged at the open end, and a mouthpiece at the other end. In particular a flow-through array technology linked to... Agent: Amster, Rothstein & Ebenstein LLP

20070161008 - Diagnostic methods for determining treatment: The present invention provides methods for identifying cancer patients susceptible to effective treatment with trastuzumab and other medications that function similarly to trastuzumab. The invention is based on the discovery that certain chromosomal abnormalities can be used to selectively identify cancer patients that are likely to be successfully treated with... Agent: Vysis, Inc Patent Department

20070161031 - Functional arrays for high throughput characterization of gene expression regulatory elements: The present invention provides compositions, kits, assemblies, libraries, arrays, and high throughput methods for large scale structural and functional characterization of gene expression regulatory elements in a genome of an organism, especially in a human genome. In one aspect of the invention, an array of expression constructs is provided, each... Agent: Wilson Sonsini Goodrich & Rosati

20070161002 - Growth differentiation factor promoter and uses therefor: GDF promoters (e.g., GDF-8 promoters) are described. Also described are methods of using the GDF promoters to regulate tissue-specific gene expression, and to identify compounds which regulate GDF expression.... Agent: Lahive & Cockfield, LLP

20070161029 - High throughput profiling of methylation status of promoter regions of genes: Rapid, sensitive, reproducible high-throughput methods for detecting methylation patterns in samples of nucleic acid, especially in the promoter region of genes which are enriched with CpG islands, are provided. The methods include isolating complexes of methylated DNA and methylation binding protein, optionally amplifying the isolated methylated DNA, and detecting the... Agent: Quine Intellectual Property Law Group, P.C.

20070160987 - Human g protein-coupled receptor and modulators thereof for the treatment of inflammatory disorders: The invention disclosed in this patent document relates to transmembrane receptors , particularly to a human G protein-coupled receptor, more particularly to a CXC chemokine receptor subtype 3 (CXCR3), and most particularly to mutated (non-endogenous) version of the human CXCR3 for evidence of constitutive activity and uses thereof. In some... Agent: Arena Pharmaceuticals, Inc.

20070161037 - Isolation and use of ryanodine receptors: The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypil) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070161018 - Method for detecting cancer and a method for suppressing cancer: An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of... Agent: Birch Stewart Kolasch & Birch

20070161019 - Method for detecting cancer and a method for suppressing cancer: An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of... Agent: Birch Stewart Kolasch & Birch

20070160990 - Method for determining the impact of a multicomponent synthetic product mixture on the biological profile of a disease within a group of living systems and the development of new combinatorial interventions: The invention provides a method for determining the impact of a chemical multicomponent mixture on the biological profile of a disease comprising the steps of: (a) determining a biological profile of the disease by comparing the biological profile of a group of living systems with symptoms of the disease with... Agent: Hoffmann & Baron, LLP

20070161036 - Method for distinguishing 5-position methylation changes of cytosine bases and cytosine-to-thymine mutations and for detecting single nucleotide polymorphisms (snps) or point mutations in genomic dna: A method is described for distinguishing 5-position methylation changes of cytosine bases and cytosine-to-thymine mutations and for the detection of single nucleotide polymorphisms (SNPs) or point mutations in genomic DNA, in which: a) a genomic DNA sample is treated with sulfite or disulfite in such a way that all of... Agent: Kriegsman & Kriegsman

20070161024 - Method for gene identification signature (gis) analysis: A method of identifying at least a nucleic acid molecule fragment to which a protein of interest binds, comprising: (i) preparing at least one nucleic acid molecule fragment to which a protein binds; (ii) isolating the 5′ terminus and the 3′ terminus of the nucleic acid fragment(s) and linking the... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070160986 - Method for identification of novel virulence associated genes: In a method of identifying novel virulence associated genetic information about a pathogenic microorganism including information about open reading frames (ORFs) having (a) assigned functions, (b) no assigned functions, (c) showing similarity with hypothetical proteins from other species is provided. An obligate human parasite evolutionary deprived of a substantial portion... Agent: Dickstein Shapiro LLP

20070161033 - Method for identifying progressive rod-cone degeneration in dogs: Provided is a method for identifying dogs as likely to be genetically normal, carriers of, or affected with progressive rod-cone degeneration comprising analyzing nucleic acids from a dog and determining the presence or absence of one or more prcd polymorphisms in the nucleic acids. Representative prcd polymorphisms characteristic of a... Agent: Hodgson Russ LLP The Guaranty Building

20070160995 - Method for investigating cytosine methylation in dna by means of dna repair enzymes: The following invention concerns a method for investigating cytosine methylation by means of DNA repair enzymes. Here, the DNA is first converted so that unmethylated cytosines are converted to uracil, while 5-methylcytosine remains unchanged. Then the DNA is hybridized to oligonucleotides, whereby hybrids will be formed with or without erroneous... Agent: Kriegsman & Kriegsman

20070161009 - Method for producing improved gene expression analysis and gene expression analysis comparison results: This invention relates to methods and means for producing microarray, non-microarray and clone counting method gene expression and gene expression comparison assay results which are, relative to such prior art produced assay results, known to be significantly improved in normalization and/or assay accuracy and/or biological accuracy, and/or quantitation, and/or interpretability... Agent: Wesley B. Ames

20070160999 - Method for simultaneous extraction of nucleic acids from a biological sample: A new method of simultaneous and separate extraction of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) from a biological sample, indifferently from fresh, frozen, fixed or autoptic tissue with a weight no less than 5 mg. The main steps of the method are: 1/sample lysis in a solution composed of... Agent: Bryan W. Bockhop, Esq.

20070160991 - Method for the methylation analysis of dna: The present invention concerns a method for the detection of methylated DNA against a background of unmethylated DNA. The double strands of the DNA to be investigated are separated and then reassociated with the formation of hemimethylated double strands. After this, the hemimethylated DNA is enzymatically converted into completely methylated... Agent: Kriegsman & Kriegsman

20070160992 - Method of detecting mutations associated with thrombosis: The present invention provides a method for the simultaneous identification of two or more single base changes in a plurality of target nucleotide sequences that are markers associated with cardiovascular diseases such as deep vein thrombosis and the like. Multiplex detection is accomplished using multiplexed tagged allele specific primer extension... Agent: Goodwin Procter LLP Patent Administrator

20070161028 - Method of dna analysis using micro/nanochannel: Methods are provided for tagging, characterizing and sorting double-stranded biomolecules while maintaining the integrity of the biomolecules.... Agent: Quarles & Brady LLP

20070161012 - Method of identifying unique target sequence: A method and system for identifying unique polynucleotide sequences within a larger polynucleotide sequence is provided which is useful for designing unique polynucleotides for any purpose, e.g., as probes, primers, transcription or translation modulators, siRNAs, capture labels, ribozymes, etc. The polynucleotides can be used in silencing or interference RNA (“siRNA”)... Agent: Millen, White, Zelano & Branigan, P.C.

20070161032 - Methods and compositions for assaying mutations and/or large scale alterations in nucleic acids and their uses in diagnosis of genetic diseases and cancers: The present invention relates to a method for detecting point mutation(s) and/or large scale alteration(s) relative to at least one nucleic acid fragment said method comprising at least the steps of providing a sample liable to contain said nucleic acid fragment and at least a second nucleic acid fragment acting... Agent: Oliff & Berridge, PLC

20070161010 - Methods and compositions for mutation analysis: In one aspect, a method for DNA mutation detection including the steps of PCR amplification using preferably Pho DNA polymerase, hybridization, and analysis by denaturing high performance liquid chromatography (DHPLC), the method preferably utilizing a PCR buffer and other solutions that are compatible with DHPLC analysis. In other aspects, compositions... Agent: Licata & Tyrrell P.C.

20070161004 - Methods and compositions involving microrna: The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.... Agent: Fulbright & Jaworski L.L.P.

20070160997 - Methods for diagnosing and for monitoring the treatment of recurrent spontaneous abortion: The present invention discloses a method of diagnosis of immunological recurrent spontaneous abortion, comprising in vitro determining the level of antinuclear antibody in a body fluid of the patient and comparing the result with the level of corresponding antinuclear antibody of normal control. Particularly, isolated chromosome No. 2 or fragment... Agent: Ladas & Parry

20070161016 - Methods of diagnosis of androgen-dependent prostate cancer, prostate cancer undergoing androgen withdrawal, and androgen-independent prostate cancer: Described herein are genes whose expression are up-regulated or down-regulated in prostate cancer. Also described are such genes whose expression is further up-regulated or down-regulated in drug-resistant prostate cancer cells. Related methods and compositions that can be used for diagnosis and treatment of prostate cancer are disclosed. Also described herein... Agent: Davis Wright Tremaine LLP

20070161025 - Methylthioadenosine phosphorylase compositions and methods of use in the diagnosis and treatment of proliferative disorders: Disclosed are novel nucleic acid and peptide compositions comprising methylthioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other... Agent: Fulbright & Jaworski L.L.P.

20070161030 - Micelle-and microemulsion-assisted planar separations platform for proteomics: A method of separating biomolecules includes providing a sample comprising one or more biomolecules, at least one of which is hydrophilic; wetting an amphiphilic planar stationary phase with a microemulsion or micelluar mobile phase; and creating an electrical field between first and second electrodes in electrical contact with opposing edges... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070161017 - Mitigation of photodamage in analytical reactions: Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage... Agent: Morgan, Lewis & Bockius LLP (sf)

20070160993 - Novel centromeric protein shugoshin: The present invention is to provide meiosis-specific novel kinetochore protein Sgo1 (shugoshin) derived from fission yeast Schizosaccharomyces pombe, and a homologue or paralogue thereof having a regulatory activity of chromosome segregation; and DNAs encoding them; as a factor ensuring the retention of unidirection and cohesion in sister centromere at meiosis... Agent: Morgan & Finnegan, L.L.P.

20070161021 - Novel nucleic acids and polypeptides related to a guanine exchange factor of rho gtpase: The present invention relates to all aspects of a guanine exchange factor (GEF), for example, a Rho-GEF, such as p115 Rho-GEF. A GEF modulates cell signaling pathways, both in in vitro and in vivo, by modulating the activity of a GTPase. By way of illustration, a p115 Rho-GEF, which modulates... Agent: Gregory Giotta, Ph.d., Esq. Onyx Pharmaceuticals, Inc.

20070161003 - Novel therapeutic targets in cancer: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel... Agent: Lisa E. Alexander Sagres Discovery, Inc.

20070161014 - Nucleic acid binding proteins: The application provides methods of designing zinc finger binding polypeptides for binding to particular target sequences comprising overlapping nucleotide quadruplets.... Agent: Townsend And Townsend And Crew, LLP

20070161027 - Oligonucleotides and analogs labeled with energy transfer dyes: Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor... Agent: Dechert LLP

20070161035 - Plant myb transcription factor homologs: This invention relates to an isolated nucleic acid fragment encoding a Myb-related transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the Myb-related transcription factor, in sense or antisense orientation, wherein expression of the chimeric gene results in production of... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070161000 - Plasmid purification: The present invention relates to a method of isolating at least one plasmid from other components of a liquid, which method comprises the steps of providing a separation matrix comprised of one or more porous carriers, which carrier(s) present anion exchange groups on external surfaces as well as pore surfaces... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070161023 - Profiling tumor specific markers for the diagnosis and treatment of neoplastic disease: A method of diagnosing cancer comprising the identification of neoplastic molecular markers is disclosed. Tumor-related or neoplastic molecular markers are identified from samples taken from a subject and the molecular profile of those markers is determined. Based upon the neoplastic molecular marker profile of the subject, the tumor sub-type is... Agent: Patterson, Thuente, Skaar & Christensen, P.A. 4800 Ids Center

20070161001 - Quantifying and profiling antibody and t cell receptor gene expression: A method of sequencing a population of polynucleotides encoding antibodies or T-cell receptors. Also provided are a method of quantifying an expression of a population of polynucleotides encoding antibodies or T-cell receptors as well as an oligonucleotide library for sequencing by hybridization of polynucleotides encoding variable regions of antibodies or... Agent: Martin D Moynihan Prtsi Inc

20070161026 - Regents labeled with energy transfer dyes: Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor... Agent: Dechert LLP

20070160994 - Repertoire determination of a lymphocyte b population: The present invention provides a process for determining the quantitative and qualitative profile of the repertoire of a given type of an immunoglobulin (Ig) heavy chain expressed by a lymphocyte B population present in a tissue sample, and kits and uses thereof. It also provides a set of VII forward... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070160985 - Secreted protein factor and cell membrane-bound splice variant: A novel mammalian protein system is disclosed. This system comprises a secreted protein factor and its related membrane-bound splice variant. These novel proteins have no homology to any known protein or class or protein, yet are ubiquitously expressed in nearly all tissue types. Also disclosed are novel nucleic acids that... Agent: Hogan & Hartson L.L.P.

20070161022 - Signatures for human aging: Age and related conditions are assessed with a gene expression test that determines the expression levels of a panel of genetic markers. Each age signature contains expression information for genes in at least one functional group that is identified herein as having an expression pattern that correlates with physiological aging... Agent: Bozicevic, Field & Francis LLP

20070161007 - Synthetic cofactor analogs of s-adenosylmethionine as ligatable probes of biological methylation and methods for their use: The present invention discloses compounds and methods used to specifically target substrates of methylation by S-adenosyl-L-methionine (SAM)-dependent methyltransferases. The substrates can be peptides, single stranded nucleic acids or double stranded nucleic acids, including RNA, DNA and PNA or phospholipids. The compounds disclosed are SAM analogs that are ligated to a... Agent: Dewitt Ross & Stevens S.c. Wisconsin Alumni Research Foundation

20070160996 - Thrombosis diagnosis/prognosis method: The invention relates to an in vitro method for the diagnosis/prognosis of thrombosis, comprising the following steps: A—the nucleic material is extracted from a biological sample, B—at least one pair of amplification primers is used to obtain amplicons of at least one target sequence of the nucleic material, C—at least... Agent: Oliff & Berridge, PLC

20070161045 - Fusion proteins based upon somatostatin receptors: The present invention is directed to fusion proteins that can be used to assay gene transfer and expression both in vitro and in vivo. The fusion proteins contain a reporter protein, e.g. a somatostatin receptor, fused to a second protein, which may be a protein fusion tag. Alternatively, a fusion... Agent: Fulbright & Jaworski L.L.P.

20070161040 - Hybrid proteins of active-site serine beta-lactamase: The present invention refers to a recombinant nucleotide sequence which codes upon expression for at least a part of a bifunctional hybrid active-site serine β-lactamase protein, wherein the β-lactamase protein is bearing at least one heterologous sequence, wherein in that the hybrid protein is having two functions, the first function... Agent: Knobbe Martens Olson & Bear LLP

20070161041 - Identification of feline or canine probnp: The invention relates to a method of determining feline or canine proBNP or fragments thereof, comprising the steps of providing a feline or canine sample, contacting the sample with at least one antibody which, when determining feline proBNP, or fragments thereof, respectively, binds to at least one epitope in the... Agent: Fulbright & Jaworski L.L.P.

20070161039 - Method for creating a database enabling the selection of at least one reaction-capable catalyst: The invention relates to a method for creating a database enabling, in particular, the selection of at least one reaction-capable catalyst, comprising the following steps: a) preparing a number of different reaction media containing the same reactivity probe and each having at least one catalyst; b) analyzing, by means of... Agent: Oliff & Berridge, PLC

20070161044 - Method for localizing and identifying isotopes: A method for localizing and identifying specific epitopes on a molecule using electron microscopy in combination with specific labeling of the epitopes by e.g. antibodies. The electron microscopy is performed using a very low electron dose, which allows the labeling molecules to remain bound to their epitopes.... Agent: Young & Thompson

20070161038 - Method of use for characterizing the catalytic reactivity of catalyst(s): A method for selecting at least one catalyst from a catalyst library on the basis of the reactivity thereof in a chemical conversion process includes: (a) testing the catalytic activity of a first catalyst from said catalyst library with respect to a reaction medium containing, as the compounds to be... Agent: Oliff & Berridge, PLC

20070161042 - Methods for characterizing molecular interactions: Methods are provided for measuring rate constants for high affinity molecular interactions using an assay format for determining dissociation rates in liquid phase. The invention uses a biosensor that at selected time intervals is contacted with a sample solution to estimate the ratio of bound vs. free ligand. Dissociation rate... Agent: Fenwick & West LLP

20070161047 - Methods of labeling transiently expressed proteins in large-scale eukaryotic cell cultures: The present invention is based on observations that transiently transfecting large-scale eukaryotic cell cultures with a polynucleotide encoding a protein of interest can be used to rapidly produce the large quantities of labeled proteins required for various biochemical techniques such as spectroscopy, microscopy, and crystallography, and applications including protein structure... Agent: Fitzpatrick Cella (wyeth)

20070161043 - Methods of preparing multicolor quantum dot tagged beads and conjugates thereof: The present invention provides a method of preparing a multicolor quantum dot-tagged bead, a multicolor quantum dot-tagged bead, a conjugate thereof, and a composition comprising such a bead or conjugate. Additionally, the present invention provides a method of making a conjugate thereof and methods of using a conjugate for multiplexed... Agent: Leydig Voit & Mayer, Ltd

20070161046 - Truncated aggrecanase molecules: Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20070161048 - Anti nc1 monoclonal antibody: The present invention dedicates to detect nephritis in early stage of either primary or secondary nephritis using an anti NC1 monoclonal antibody. The present invention dedicates to provide useful information for diagnosis of renal function to detect NC1 by immunofluorescent stain method in renal biopsy section obtained at early stage... Agent: Knobbe Martens Olson & Bear LLP

20070161053 - Chimeric human sweet-umami and umami-sweet taste receptors: This invention relates to chimeric taste receptors comprising the extracellular portion of one T1R or a variant or fragment thereof, either T1R1 or T1R2, and the transmembrane portion of another T1R or a variant or fragment thereof, either T1R1 or T1R2, preferably associated with a T1R3 polypeptide and a suitable... Agent: Hunton & Williams LLP Intellectual Property Department

20070161051 - Device for cell separation and analysis and method of using: A microflow device for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts which are arranged across the width of a collection region in an irregular or set random pattern so as... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070161049 - Method and device for controlling the positioning of a biological element on a support: A method for controlling directly and in real time positioning of a biological element on a zone of a support, in which the biological element is labeled with a tracer that emits a light radiation and the zone of the support is located in a layer of a material capable... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070161054 - Methods and compositions for targeting secretory lysosomes: This invention relates to methods and compositions for targeting proteins to secretory lysosomes. The invention further provides methods of use in drug screening assays, and methods of purifying secretory lysosomes.... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20070161050 - Monoclonal antibodies to mesenchymal stem cells: The present invention relates to monoclonal antibodies specifically binding to a membrane antigen of human mesenchymal stem cells, hybridoma cell lines producing the same, and methods for identifying or isolating human mesenchymal stem cells using the same. The monoclonal antibodies of this invention exhibit excellent specificity to human mesenchymal stem... Agent: Clark & Elbing LLP

20070161052 - Trpm5 based assays and the use thereof for the identification of modulators of sweet, bitter or umami (savory) taste: Robust cell based assays are provided that use cells that express wild-type or modified TRPM5 nucleic acid sequences in order to identify putative taste modulators, preferably sweet, bitter and umami taste modulators. The preferred assays use HEK-293 cells that express TRPM5, optionally at least one GPCR, preferably a taste specific... Agent: Hunton & Williams LLP Intellectual Property Department

20070161056 - Multiplexed detection of anti-red cell alloantibodies: Disclosed are methods for detecting antibody in a sample, where the antibody targets an antigen expressed by red blood cells or red blood cell ghosts. Rather than detecting the binding events between a particular antigen antibody pair (as in traditional agglutination based assays) the methods herein allow for multiplexed detection... Agent: Eric P. Mirabez

20070161057 - Methods, compositions, and kits for detecting cyrptosporidium pathogens: The invention provides an efficient, sensitive, and reliable method for detection of parasites such as Cryptosporidium by efficiently extracting molecular markers or antigens using non-ionic detergents and ECL detection, and kits and compositions for performing such methods.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070161064 - Antibodies as a cancer diagnostic: Method and kits are provided for the detection and diagnosis of metastatic disease. More particularly, the methods and kits employ compounds that can detect EphA2, a specific epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells. In one embodiment the compound is an antibody capable of binding to... Agent: Mueting, Raasch & Gebhardt, P.A.

20070161063 - Identifying, monitoring, and treating women for breast precancer or cancer: The invention is to methods for screening women for breast cancer and precancer by determining a level of an estrogen-related marker. The invention further provides methods of treating such patients identified as having one or more abnormal ductal epithelial cells and an estrogen-related marker. The invention provides methods for screening... Agent: Cytyc Corporation

20070161058 - Methods and compositions for diagnosing hepatocellular carcinoma: Methods for the diagnosis of hepatocellular carcinoma (HCC) are set forth. Improved assay methods and scanning methods are included that employ non-cell-associated and cell-associated HCC related proteins. Such methods are based upon the discovery of genes that were up-regulated in diseased versus normal tissue as well as in HCC tissue... Agent: Davis Wright Tremaine, LLP

20070161059 - N1,n12-diacetylspermine as tumor marker: A tumor marker comprising diacetylspermine, and a method of evaluating the state of a tumor, comprising reacting an antibody to diacetylspermine with a biological sample to thereby detect diacetylspermine and evaluating the state of the tumor using the obtained detection results as an indicator.... Agent: Dickstein Shapiro LLP

20070161061 - Novel composition and methods for the treatment of immune related diseases: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related diseases.... Agent: Genentech, Inc.

20070161062 - Protein cbp2 as a marker for colorectal cancer: The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein CBP2 (collagen-binding protein 2) in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a liquid sample, derived from an individual by measuring CBP2 in said sample.... Agent: Roche Diagnostics Operations Inc.

20070161060 - Screening method for identifying an agent that modulates pipkigamma trafficking of e-cadherin: The present disclosure teaches that PIPKIγ binds cadherins and adaptor protein μ-subunits and mediates trafficking of cadherins to and from the plasma membrane. Thus, the present invention relates to a method for identifying agents which modulate the trafficking or binding activities of a PIPKIγ. A method for diagnosing and prognosing... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20070161065 - Diagnosis, prevention and treatment of crohn's disease using the ompc antigen: The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.... Agent: Townsend And Townsend And Crew, LLP

20070161055 - Immunosorbent assay support and method of use: Embodiments of the present invention provide an immunosorbent assay support immobilized with an intermediate binding antibody and their method of use in an improved immunoassay format.... Agent: Invitrogen Corporation C/o Intellevate

20070161066 - Immunoglobulin e detection in mammalian species: The present invention provides antibodies (e.g., monoclonal antibodies) that specifically binds to mammalian IgE (e.g., dog IgE). In some embodiments the antibodies bind to an epitope between amino acids 145-166 of mammalian IgE; in other embodiments the antibodies bind to an epitope between amino acids 356-374 of mammalian IgE. The... Agent: Myers Bigel Sibley & Sajovec

20070161067 - Split protein self complementing fragments, systems, and methods of use thereof: Briefly described, embodiments of this disclosure include split protein systems, fusion proteins, methods of producing the split protein systems, methods of screening macromolecular delivery vehicles, methods of cellular localization of proteins, methods of monitoring cell fusion, methods of detecting phosphorylation, and the like.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070161068 - Method, reagent and kit for determination of cholesterol in very low-density lipoprotein remnant (vldl remnant): According to the present invention, esterified and free cholesterol in very low-density lipoprotein remnant (hereinafter collectively referred to as very low-density lipoprotein remnant cholesterol) in a sample is determined in an aqueous medium containing the sample in the presence of a combination of (a) a polyoxyethylene-polyoxyalkylene alkylaryl ether and (b)... Agent: Fitzpatrick Cella Harper & Scinto

20070161069 - Biosensor and its use: The present invention relates to a biosensor comprising a substrate with a coating system in which a Ruthenium complex and an enzyme is integrated. The enzyme is able to convert bioproducts, e.g. glucose, fructose or glycerol. The depletion of oxygen during these converting reactions can be monitored via the fluorescence... Agent: Leydig Voit & Mayer, Ltd

20070161070 - Method for determining the concentration of an analyte in a liquid sample using small volume samples and fast test times: Analytes in a liquid sample are determined by methods utilizing sample volumes of less than about 1.5 μl and test times within ten seconds. The methods are preferably performed using small test strips including a sample receiving chamber filled with the sample by capillary action.... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20070161071 - Assay methods and systems: Methods, systems, kits for carrying out a wide variety of different assays that comprise providing a first reagent mixture which comprises a first reagent having a fluorescent label. A second reagent is introduced into the first reagent mixture to produce a second reagent mixture, where the second reagent reacts with... Agent: Caliper Life Sciences, Inc.

20070161072 - Neuroprotection by inhibition of diacyglycerol kinase epsilon activity: The present invention includes the characterization of the DGKε gene and the generation of screening methods for compounds that inhibit the function of DGKε. The DGK family of enzymes occupies a signaling crossroads since they catalyze the phosphorylation of DAG to produce PA. Both the substrate (DAG) and the product... Agent: Madson & Austin Gateway Tower West

20070161074 - Diagnostic method of mucopolysaccharidoses: Provision of a method for accurate diagnosis of mucopolysaccharidoses, including determining the level of glycosaminoglycan in a biological sample with high sensitivity and with ease. A diagnostic method of mucopolysaccharidoses including the following steps (1) and (2): (1) a step including (a) filtering a biological sample with an ultrafiltration filter,... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070161073 - Methods and products related to evaluating the quality of a polysaccharide: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.... Agent: Wolf Greenfield & Sacks, P.C.

20070161075 - Fluorescence microscope arrangement: The invention relates to a microscope arrangement and to a method with which the spatial distribution of a magnetically and/or electrically sensitive fluorescent marker (21) in a sample (20) can be determined. Fluorescence radiation (VF) is excited by primary radiation (VE) in the sample (20) and imaged by a microscope.... Agent: Philips Intellectual Property & Standards

20070161076 - Methods and systems for sampling, screening, and diagnosis: Apparatus, systems, and methods for detecting, screening and sampling of cells are disclosed.... Agent: Edwards Angell Palmer & Dodge LLP

20070161077 - Thermacetogenium phaeum consortium for the production of materials with enhanced hydrogen content: An isolated microbial consortium is described that includes a first microbial consortium having Thermacetogenium phaeum to metabolize a complex hydrocarbon substrate into metabolic products comprising an acetate compound. The consortium also includes a second microbial consortium having a methanogen to convert the acetate compound into a final product that includes... Agent: Townsend And Townsend And Crew, LLP

20070161080 - Antibodies: The use of an ScFv Ab (ScFv Ab) capable of recognising a disease associated molecule (DAM) in the manufacture of a medicament for the prevention and/or treatment of a disease condition associated with a DAM is described. The ScFv Ab has therapeutic, diagnostic and prognostic applications.... Agent: Townsend And Townsend And Crew, LLP

20070161083 - Codon optimized recombinant dermaphagoides allergens: The present invention relates to codon optimised polynucleotides which are efficiently expressed in mammalian cells and encode insect proteins from Dermaphagoides dust mite. In particular, the optimised codon polynucleotides encode a protein from Dermaphagoides pteronyssinus, such as DerP1 or proDerP1. The present invention also provides methods of preparing pharmaceutical compositions... Agent: Glaxosmithkline Corporate Intellectual Property - Uw2220

20070161081 - Hepatocyte growth factor intron fusion proteins: Isoforms of ligands, including isoforms of hepatocyte growth factor (HGF) containing an intron-encoded portion, and pharmaceutical compositions containing HGF isoforms are provided. The HGF ligand isoforms and compositions containing them can be used in methods of treatment of diseases, such as cancer and other angiogenic diseases.... Agent: Morrison & Foerster LLP

20070161082 - Lipase variants: Attaching a peptide extension to the C-terminal amino acid of a lipase reduces the tendency to form odor. This may lead to lipase variants with a reduced odor generation when washing textile soiled with fat which includes relatively short-chain fatty acyl groups (e.g., up to C8) such as dairy stains... Agent: Novozymes North America, Inc.

20070161078 - Methods and compositions for diagnosis and treatment of influenza: The invention provides method and compositions for determining the presence and amount of an influenza virus in a sample including high risk strains of Influenza A. Also provided are methods for determining whether a subject is infected with a influenza virus, as well as, the type and strain of the... Agent: Townsend And Townsend And Crew, LLP

20070161085 - Methods of producing influenza vaccine compositions: Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.... Agent: Johnathan Klein-evans

20070161086 - Novel ecdysone receptor-based induicible gene expression system: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large... Agent: Sughrue Mion, PLLC

20070161084 - Production of glycoproteins using manganese: Culture media comprising manganese and methods of culturing cells to improve sialylation and glycosylation of glycoproteins are provided.... Agent: Marshall, Gerstein & Borun LLP

20070161079 - Recombinant cell clones having increased stability and methods of making and using the same: Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention... Agent: Baxter Healthcare Corporation

20070161087 - Glp-1 fusion proteins: The present invention relates to glucagon-like-1 compounds fused to proteins that have the effect of extending the in vivo half-life of the peptides. These fusion proteins can be used to treat non-insulin dependent diabetes mellitus as well as a variety of other conditions.... Agent: Eli Lilly & Company

20070161088 - Beta immunogenic peptide carrier conjugates and methods of producing same: The present invention is directed to methods of producing conjugates of Aβ peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and... Agent: Sughrue Mion, PLLC

20070161089 - Method of producing pan-specific antibodies: Pan-specific anti-humanized antibody antibody (anti-hzAbAb) are described as well as and methods for generating and using pan-specific anti-humanized antibody antibodies (anti-hzAbAb) that selectively bind related antibodies such as those therapeutic humanized having variable domain framework regions sharing at least 80% sequence identity and/or those having variable domain framework regions sharing... Agent: Merchant & Gould PC

20070161090 - Method for producing purine nucleoside by fermentation: A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated repressor of purine nucleotide biosynthesis encoded by purR, a... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070161091 - Corynebacterium glutamicum genes encoding proteins involved in genetic stability, gene expression, and protein secretion and folding: Isolated nucleic acid molecules, designated SES nucleic acid molecules, which encode novel SES proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SES nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070161092 - Production of clavulanic acid by genetic engineering of streptomyces clavuligerus: Genetically engineered Streptomyces clavuligerus strains with improved capabilities to produce clavulanic acid are provided. The strains are genetically engineered by disrupting newly identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) genes. This results in an increased intracelluar pool of the clavulanic acid precursor D-glyceraldehyde-3-phosphate (D-G3P), and increased clavulanic acid production. Clavulanic acid production may... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070161093 - Microbial production of vitamin c: The present invention provides a process for the production of vitamin C from a substrate, such as for instance L-sorbosone using a microorganism belonging to the genus Ketogulonicigenium.... Agent: Nixon & Vanderhye, PC

20070161094 - Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives: The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for... Agent: Dechert LLP

20070161095 - Biomass fuel synthesis methods for increased energy efficiency: A high efficiency method for synthesizing biomass fuels leveraging the synergistic impact of ionic liquids on both the significant gains in pretreatment of biomass and the utilization of the combination of ionic liquids and carbon dioxide under supercritical conditions for energy generation is provided. The strategic use of heat exchangers,... Agent: Michael H. Gurin

20070161097 - Deregulated bacteria with improved polyhydroxyalkanoate production: Mutant bacteria with improved poly-3-hydroxylalkanoate (PHA)-producing characteristics and methods of producing and using them are provided.... Agent: The Procter & Gamble Company Intellectual Property Division - West Bldg.

20070161096 - Process for recovering polyhydroxialkanoates (\"phas\") from cellular biomass: A process for recovering polyhydroxyalkanoates (PHAs) from cellular biomass of bacteria, said biomass being obtained by fermentation and in the form of a cellular biomass slurry in aqueous suspension, comprising the steps of: submitting the slurry to operations of injection of PHA solvent, agitation and heating, in order to form... Agent: Darby & Darby P.C.

20070161098 - Method for producing lactic acid: Lactic acid with high optical purity that has not previously been achieved is produced. It has been found that the optical purity of lactic acid is reduced as the racemization reaction of lactic acid proceeds when lactic acid coexists with glycerol. By reducing the amount of glycerol prior to concentrating... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070161099 - Methods for using polypeptides having amylase activity and nucleic acids encoding them: The invention relates to uses of polypeptides having amylase activity, nucleic acids encoding them, and methods for making and using them. For example, in one aspect, the invention provides methods for making alcohol using polypeptides of the invention. In one aspect, the polypeptides having amylase activity have increased activity and... Agent: Diversa C/o Mofo S.d.

20070161100 - Photosensitive resin composition and cured product thereof: e

20070161101 - Method of forming planar lipid double membrane for membrane protein analysis and apparatus therefor: To provide a method of forming a planar lipid-bilayer membrane for membrane protein analysis, by which downsizing, simplifying, and multichanneling of a device therefor are achieved. A planar lipid-bilayer membrane 24 is formed by filling a microchannel 12 with a buffer solution 18, the microchannel 12 disposed under a horizontal... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070161102 - Microchannel biosensor strip capable of simultaneously detecting different human physiological information: This invention discloses a microchannel biosensor strip capable of simultaneously detecting different human physiological information, and particularly a biosensor strip structure has a plurality of microchannels, such that various physiological information can be detected by human body fluid (such as blood), and the test strip has a plurality of microchannels,... Agent: Bacon & Thomas, PLLC

20070161103 - Device and method for the visual analysis of test strips: A device for the visual analysis of test strips, each having at least one delimited area in which, after contact with a sample to be examined, a visually detectable signal can be generated, with the device having a positioning device including a seat for at least one test strip or... Agent: Rankin, Hill, Porter & Clark LLP

20070161104 - Waste management facilities for the production of hydrogen gas and reduction of greenhouse gases: A waste management facility is provided with operational control of a waste mass for optimum hydrogen production. The facility includes an air circulation control facility cooperating with the waste mass, a liquid introduction system cooperating within the waste mass, a monitoring mechanism for optimum operation of the waste management facility,... Agent: Welsh & Flaxman LLC

20070161106 - Cultured cell and method and apparatus for cell culture: One or more cells can be cultured when confined in space by barriers. The distance between barriers can be comparable to the size of a cell to be cultured. The space between barriers can also be sufficiently small to allow control of cell properties or monitoring of the cell(s) cultured... Agent: Smart And Biggar

20070161105 - Method of forming organ: A method for forming an organ and/or tissue from undifferentiated cells derived from a vertebrate animal in vitro, which comprises the step of culturing the undifferentiated cells derived from a vertebrate animal in the presence of a retinoic acid X receptor ligand (e.g., a retinoic acid X receptor agonist or... Agent: Greenblum & Bernstein, P.L.C

20070161107 - Differentiation of human embryonic stem cells to cardiomyocytes: A method for inducing cardiomyocyte differentiation of a hES cell, the method comprising co-culturing the hES cell with a cell excreting at least one cardiomyocyte differentiation inducing factor or with an extracellular medium therefrom, under conditions that induce differentiation, cells and cell populations so produced, and uses of the cells.... Agent: Scully, Scott, Murphy & Presser, P.C.

20070161108 - Bob-1 specific t cells and methods to use: The present invention refers to the use of Bob-1 protein, fragments or epitopes thereof and/or related sequences in a method to identify, to induce and/or to isolate Bob-1 specific or Bob-1 cross-reactive T-cells, preferably cytotoxic T-lymphocytes (CTL) and CD4+ T-helper cells. The T-cells according to the invention can be used... Agent: Graybeal, Jackson, Haley LLP

20070161109 - Suturable dural and meningeal repair product comprising collagen matrix: A matrix for tissue growth includes: (a) a first layer including a first assembly of collagen fibers; (b) a plurality of projections on a top surface of the first layer; and (c) a second layer bonded to a bottom portion of the first layer and including a second assembly of... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20070161110 - Methods for producing minus-strand rna viral vectors using hybrid promoter comprising cytomegalovirus enhancer and chicken beta-actin promoter: The present invention provides methods for producing a minus-strand RNA viral vector, which comprise using a promoter comprising a cytomegalovirus enhancer and a chicken β-actin promoter, to induce the transcription of the genome RNA of a minus-strand RNA viral vector and the expression of minus-strand RNA viral proteins that form... Agent: Clark & Elbing LLP

20070154891 - Helical wrapping of single-walled carbon nanotubes by genomic dna: A structure and method for forming single-stranded DNA segments/single-wall carbon nanotube complexes and a method of preparing single-stranded DNA segments. The method for forming single-stranded DNA segments/single-wall carbon nanotube complexes including: attaching single-stranded DNA segments to single-wall carbon nanotubes to form single-stranded DNA segment/single-wall carbon nanotube complexes, each of the... Agent: Schmeiser, Olsen & Watts

20070154922 - Molecular diagnostics amplification system and methods: The present invention relates to automated devices and methods for the amplification of segments of nucleic acid in a convenient and portable manner. A single-use nucleic acid amplification device for producing an amplicon includes a housing and an amplification chamber. The chamber includes an ingress with a first reversible seal,... Agent: Patent Administrator Katten Muchin Rosenman LLP

20070154962 - Bcl-2 promoted cell death: The invention is directed towards a method of screening compounds that disrupt Bcl-2/FKBP38 binding and thereby induce apoptosis. The invention is also directed towards a method of promoting apoptotic cell death in Bcl-2 producing cells or tissues by contacting said cells or tissues with a sufficient amount of BH4 peptide... Agent: Gordon & Rees LLP

20070154877 - Method for the direct culture of dendritic cells without a preceding centrifugation step: The present invention provides a method for the direct culture of dendritic cell precursors enriched by elutriation without a preceding centrifugation step to generate dendritic cells.... Agent: Needle & Rosenberg, P.C.

20070154878 - Detection apparatus and detection method: The present invention provides a detection apparatus, including: signal outputting means configured to output signals of a frequency band within which the difference in electric characteristic between different tissues of a living organism is higher than a predetermined level individually to two or more electrodes; impedance detection means configured to... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070154879 - Method for quantitatively determining a specific component in a biological specimen, and reagent for quantitative determination: A method for quantitatively determining a specific component in a biological specimen, which includes reacting a biological specimen, in the presence of an electron acceptor, with an enzyme which has an ability, by the dehydrogenation reaction, to oxidize the specific component or a substance derived from the specific component, and... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070154884 - Assessment of human papilloma virus-related disease: This invention provides novel methods for assessing HPV infection. Gene expression levels are used to assess the progression of HPV infection from benign to malignant growth. Also provided are kits for carrying out the methods of this invention.... Agent: Morgan & Finnegan, L.L.P.

20070154882 - Beta-polypeptides that inhibit cytomegalovirus infection: Disclosed are beta-polypeptides that mimic the coiled-coil regions of gB and gH by display of the key hydrophobic residues for coiled-coil packing along one face of beta-polypeptide 12-helix. The most potent inhibitor blocks infection of CMV with an IC50 of approximately 20 m.... Agent: Dewitt Ross & Stevens S.c.

20070154881 - Method, system and device for performing biological assays and detecting biomolecules and cells: The application relates to a method, system and device for performing biological assays. The method, system and device allow more accurate and specific detections of biomolecules in multiplex assays, such as immunoassays and DNA microarray assays. More specifically, the embodiments of the invention allow the detection of labels after their... Agent: Morrison & Foerster LLP

20070154885 - Process for detecting prp using a macrocyclic adjuvant ligand: A process for detecting the forms of the prion pathogens responsible for subacute, transmissible, spongiform encephalopathies, including a macrocyclic adjuvant ligand (AML), free or bound to a support, that is added to a biological sample capable of containing PrPsc, the resulting suspension then being reacted with an anti-PrPsc antibody, and... Agent: Ip Group Of Dla Piper US LLP

20070154880 - Process for the preparation and purification of recombinant proteins: A novel process for the purification of recombinant protein expressed as particle is herewith described. In this purification process, the protein is purified by hydrophobic interaction. The interaction of this protein step resulted in an increase in recovery and purity from 15%-80%. the protein further purified has its application in... Agent: Louis M Heidelberger Reed Smith

20070154883 - Soluble rubella e1 envelope protein variants: The invention disclosed relates to a soluble rubella E1 antigen and variants of this peptide characterized by lacking at the C-terminal end at least the transmembrane region and the anchor segment as well as at least the amino acids 143 to 164 and containing at least the region spanning the... Agent: Roche Diagnostics Operations Inc.

20070154914 - 2'-terminator related pyrophosphorolysis activated polymerization: The present invention provides reaction mixtures that include blocked oligonucleotides comprising 2′-terminator nucleotides. The blocked oligonucleotides are rendered extendible when the 2′-terminator nucleotides are removed from the oligonucleotides, e.g., via pyrophosphorolysis. The reaction mixtures can be used in various nucleic acid polymerization and/or amplification assays, among many other applications. In... Agent: Roche Molecular Systems Inc Patent Law Department

20070154918 - 44 human secreted proteins: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070154910 - 50 human secreted proteins: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further re lates to diagnostic and therapeutic methods useful for... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070154912 - 87 human secreted proteins: The present invention relates to 87 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070154934 - Assays employing randomly distributed microbeads with attached biomolecules: A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relics on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates;... Agent: Eric P. Mirabez

20070154899 - Biodetection by nucleic acid-templated chemistry: The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid templated chemistry, for example, by generating fluorescent, chemiluminescent and/or chromophoric signals.... Agent: Goodwin Procter LLP Patent Administrator

20070154897 - Biomarkers for kidney diseases and method for using same: The present invention provides biomarkers for detecting kidney disease, selected from the oligonucleotide sequence, complementary sequence or derivatives, amino acid sequence or derivatives, fragment, variants, antibody of annexin A2 or S100A6 or combinations thereof. Moreover, the present invention also provides an assay kit and a method for kidney disease detecting,... Agent: Bacon & Thomas, PLLC

20070154886 - Composition, splice variants and methods relating to ovarian specific genes and proteins: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of... Agent: Licata & Tyrrell P.C.

20070154917 - Compositions and method for treating viral infections: Methods and compositions for treatment, diagnosis, and prevention of a virus comprise administering to a patient antibodies which react with regions of viral proteins and result in neutralization of infectivity and inactivation of functionally essential events in the life cycle of the virus. The antibodies recognize viral epitopes which fail... Agent: Factor & Lake, Ltd

20070154908 - Connective tissue growth factor-2: The present invention relates to a human CTGF-2 polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonist/inhibitors against such polypeptide. Also provided are methods of using the polypeptide therapeutically for enhancing the repair of connective and... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070154898 - Dark quenchers for donor-acceptor energy transfer: The present invention provides a family of dark quenchers, termed Black Hole Quenchers (“BHQs”), that are efficient quenchers of excited state energy but which are themselves substantially non-fluorescent. Also provided are methods of using the BHQs, probes incorporating the BHQs and methods of using the probes.... Agent: Morgan, Lewis & Bockius LLP (sf)

20070154929 - Delivery point sequencer and method of use: Device for sequencing disparate products, includes at least a first feeder mechanism feeding a first separate stream of a first product type in a pre-sequenced order. At least a second feeder mechanism feeds a second separate stream of second product type though a sequencing process. At least one reading device... Agent: Greenblum & Bernstein, P.L.C

20070154892 - Differential amplification of mutant nucleic acids by pcr in a mixure of nucleic acids: A method for enriching a mutant nucleic acid in a mixture of nucleic acids, wherein the method comprises: (a) providing a nucleic acid mixture comprising a parental nucleic acid and a mutant nucleic acid of the parental nucleic acid; and (b) amplifying the nucleic acids in the nucleic acid mixture... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070154927 - Energy transfer dyes with enhanced fluorescence: Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor... Agent: Dechert LLP

20070154931 - Genes associate with progression and response in chronic myeloid leukemia and uses thereof: The invention provides molecular markers that are associated with the progression of chronic myeloid leukemia (CML), and methods and computer systems for monitoring the progression of CML in a patient based on measurements of these molecular markers. The present invention also provides CML target genes, and methods and compositions for... Agent: Jones Day

20070154935 - Human obesity susceptibility gene and uses thereof: The present invention discloses the identification of a human obesity susceptibility gene; which can be used for the diagnosis, prevention and treatment of obesity and related disorders, as well as for the screening of therapeutically active drugs. The invention more specifically discloses that the PPYR1 gene on chromosome 10 and... Agent: Nixon & Vanderhye, PC

20070154893 - Implantable cell/tissue-based biosensing device: An implantable cell/tissue-based biosensor device detects and/or monitors the amount of one or more specific analytes within a patient. Stimulation circuitry stimulates the cells/tissue of the biosensor device causing the cells/tissue to evoke a response that is altered by the presence of a specific analyte. Sensing circuitry detects the evoked... Agent: Medtronic, Inc.

20070154939 - Instrument for monitoring polymerase chain reaction of dna: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the... Agent: Kilyk & Bowersox, P.l.l.c.

20070154894 - Labeling and non-enzymatic fragmentation of cdna using a ribonucleoside triphosphate analog: are incorporated into the growing strand of a cDNA by a reverse transcriptase or a mutant reverse transcriptase. After subject the strands to Mg2+, base and heat, the 3′ OH causes cleavage of the cDNA leaving a 2′OH phosphate with a biotin label. The biotin provides a label which may... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070154921 - Method and system for phase-locked sequencing: System and methods according to exemplary embodiments of the present disclosure utilize a sample holder configured to hold at least one confined single-molecule analyte in a solution of labeled nucleotide bases. Each single-molecule analyte has a single template nucleic acid molecule, an oligonucleotide primer, and/or a single nucleic acid polymerizing... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070154932 - Method for attachment of silylated molecules to glass surfaces: A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070154890 - Method for detecting biomolecule, labeling dye used therefore, and labeling kit: The present invention provides a method for detecting a biomolecule. The method includes reacting a biomolecule sample with an organic EL-dye and measuring the fluorescence of the biomolecule sample labeled with the organic EL-dye. The method provides a highly sensitive method of detecting a biomolecule at lower cost.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070154915 - Method for detecting cancer and a method for suppressing cancer: An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of... Agent: Birch Stewart Kolasch & Birch

20070154916 - Method for detecting cancer and a method for suppressing cancer: An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of... Agent: Birch Stewart Kolasch & Birch

20070154940 - Method for detecting target nucleic acid: A target nucleic acid having a target sequence in a sample is detected according to the steps of: (a) mixing a first probe including a nucleic acid which has a specific region having a sequence complementary to the target sequence and a nonspecific region having a sequence that is not... Agent: Knobbe Martens Olson & Bear LLP

20070154923 - Method for gridding and quality control of polymer arrays: Methods of using a plurality of control probes for gridding of a nucleic acid array and for quality control purposes are disclosed.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070154913 - Method for preparing active nanoarchaeum equitans dna polymerase and the active dna polymerase prepared by the method: Disclosed are a method of preparing an active Nanoarchaeum equitans B-type DNA polymerase (Neq DNA polymerase), an active Neq DNA polymerase prepared according to the method, and a polymerase chain reaction (PCR) using the active Neq DNA polymerase. The active Neq DNA polymerase may be used in various nucleic acid... Agent: Medlen & Carroll, LLP

20070154888 - Method for the covalent immobilization of probe biomolecules on organic surfaces: The invention relates to a method for the covalent immobilization of probe biomolecules on organic surfaces, by means of photoreactive cross-linking agents which are used to covalently immobilize the probe biomolecules on organic surfaces, or to covalently bind said probe biomolecules to soluble polymers or copolymers that are then covalently... Agent: The Webb Law Firm, P.C.

20070154887 - Method for the identification of syntenic regions: The identification of the syntenic regions of a given genomic fragment conventionally involves a similarity-based search, and then taking the best hits and extending them manually until the whole region of interest is covered. Such a process is labor intensive and not suitable for a pipeline with thousands of sequences... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070154938 - Method of inspecting a dna chip and apparatus thereof: A DNA inspecting apparatus including driving means for relatively changing positions of the multi-spot lights and a position of the DNA chip so as to detect the fluorescent lights in such a manner that a desired area on the DNA chip is irradiated with the multi-spot lights, and a control... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070154889 - Methods and reagents for the detection of melanoma: An assay for identifying a malignant melanocyte is conducted by determining whether differential expression of particular genes is indicative of melanoma exceed a cut-off value. The assay can be performed intra-operatively on lymph node tissue.... Agent: Philip S. Johnson Johnson & Johnson

20070154900 - Methods for determining protein and peptide terminal sequences: Methods and apparatuses for deriving the sequence of an oligomer. In one exemplary method for deriving the sequence of a polypeptide, a predetermined set of mass/charge values for amino acid sequences is stored. An abundance value from mass spectrum data for each mass/charge value in the predetermined set is determined... Agent: Paul, Hastings, Janofsky & Walker LLP

20070154904 - Methods for identifying novel nucleic acid regulatory elements and compounds that affect the regulation: Described herein are methods for identifying novel nucleic acid regulatory elements and compounds that modulate the regulation of such elements. Also described herein are nucleic acid sequence identified as novel nucleic acid regulatory elements and host cells containing such nucleic acid regulatory elements in a vector.... Agent: Clark & Elbing LLP

20070154936 - Methods for identifying target genes, gene expression profiles, and biochemical/signal transduction pathways associated with specific patterns of hemodynamic shear stress and atherogenesis and uses thereof: Differentially expressed genes and profiles of differentially expressed genes associated with hemodynamic shear stress in vivo in mammalian vasculature are provided. Methods for identifying such profiles and using these profiles to identify and target regions of the vasculature with anti-atherogenic therapies are provided. Also provided are methods of identifying agents... Agent: Licata & Tyrrell P.C.

20070154943 - Methods for preventing cattle reproductive diseases: The present invention relates to methods for treating or preventing diseases or disorders in a pregnant cow and calf nursing a pregnant cow caused by infection by Bovine Viral Diarrhea Virus (BVDV) Types 1 and 2, Bovine Herpes Virus Type-1 (BHV-1), Bovine Respiratory Syncytial Virus (BRSV), Parainfluenza Virus (PIV3), Campylobacter... Agent: Scully Scott Murphy & Presser, PC

20070154925 - Methods of analyzing polynucleotides employing energy transfer dyes: Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor... Agent: Dechert LLP

20070154926 - Methods of analyzing polynucleotides employing energy transfer dyes: Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor... Agent: Dechert LLP

20070154928 - Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer: Described herein are genes whose expression are up-regulated or down-regulated in ovarian cancer. Related methods and compositions that can be used for diagnosis and treatment of ovarian cancer are disclosed. Also described herein are methods that can be used to identify modulators of ovarian cancer.... Agent: Pdl Biopharma, Inc.

20070154906 - Methods to identify therapeutic candidates: The invention provides systematic methods for identification of candidate compounds useful in treatment of conditions initiated or modulated by genetic expression. The methods of the invention permit efficient identification of candidates suitable for verification testing by in vitro and/or in vivo models.... Agent: Morrison & Foerster LLP

20070154907 - Microemulsions as precursors to solid nanoparticles: The preparation of novel microemulsions to be used as precursors for solid nanoparticles is described. The microemulsion precursors consist of either alcohol-in-fluorocarbon microemulsions, liquid hydrocarbon-in-fluorocarbon microemulsions, or liquid hydrocarbon-in-water microemulsions. The formed solid nanoparticles have diameters below 200 nanometers and can be made to entrap various materials including drugs, magnets,... Agent: Fulbright & Jaworski L.L.P.

20070154905 - Modulators of the function of fas receptors and other proteins: The present invention provides proteins capable of modulating or mediating the FAS receptor ligand or TNF effect on cells carrying FAS receptor or p55 receptor by binding or interacting with MORT-1 protein, which in turn binds to the intracellular domain of the FAS receptor or to another protein TRADD which... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070154942 - Multi-array systems and methods of use thereof: Multi-array systems useful for performing assays on multiple biomolecule arrays simultaneously while minimizing sample volume are provided. Apparatuses and kits comprising the multi-array systems also provided. Methods of using the multi-array systems in assays such as hybridization arrays are also provided, as well as methods of producing the multi-array systems.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070154895 - Multi-assay microfluidic chips: This invention provides systems and methods of running multiple different analyses on a microfluidic device. Results from such analyses can be useful in high throughput screening of samples or correlation of multiple as... Agent: Caliper Life Sciences, Inc.

20070154937 - N-sulfonyldicarboximide containing tethering compounds: Compounds having two reactive functional groups are described that can be used as a tethering compound to immobilize an amine-containing material to a substrate. The first reactive functional group can be used to provide attachment to a surface of a substrate. The second reactive functional group is a N-sulfonyldicarboximide group... Agent: 3m Innovative Properties Company

20070154920 - Novel ectoparasite saliva proteins: The present invention is directed to a novel product and method for isolating ectoparasite saliva proteins, and a novel product and method for detecting and/or treating allergic dermatitis in an animal. The present invention includes a saliva protein collection apparatus capable of collecting ectoparasite saliva proteins substantially free of contaminating... Agent: Sheridan Ross PC

20070154924 - Oligonucleotides and analogs labeled with energy transfer dyes: Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor... Agent: Dechert LLP

20070154902 - Papilloma virus vaccine: A method of providing papilloma virus like particles which may be used for diagnostic purposes or for incorporation in a vaccine for use in relation to infections caused by papilloma virus. The method includes an initial step of constructing one or more recombinant DNA molecules which each encode papilloma virus... Agent: Foley And Lardner LLP Suite 500

20070154919 - Pim-3 kinase as a target for type 2 diabetes mellitus: The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2... Agent: Ross J. Oehler Sanofi-aventis U.s. LLC

20070154930 - Process to study changes in gene expression in stem cells: The present invention includes a method to identify stem cell genes that are differentially expressed in stem cells at various stages of differentiation when compared to undifferentiated stem cells by preparing a gene expression profile of a stem cell population and comparing the profile to a profile prepared from stem... Agent: Morgan Lewis & Bockius LLP

20070154941 - Production of weakly active or inactive mutants of alkaline phosphatase and their expression in yeast: The invention concerns a method for the recombinant production or expression of eukaryotic alkaline phosphatase mutants in yeast cells wherein the specifically introduced mutations result in a reduction of the specific AP activity by at least a factor 1:100. The invention also concerns a method for inserting corresponding nucleic acid... Agent: Roche Diagnostics Operations Inc.

20070154933 - Reagents and methods for identifying gene targets for treating cancer: The invention provides methods and reagents for identifying mammalian genes necessary for tumor cell growth as targets for developing drugs that inhibit expression of said genes and inhibit tumor cell growth thereby.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070154911 - Regulatory protein pke#83 from human keratinocytes: The invention relates to an isolated polypeptide which is the same as or similar to (i.e., has the same function and effect as) a protein which occurs naturally in human keratinocytes and is more strongly expressed when the keratinocytes are in their activated state. The invention also relates to an... Agent: Akerman Senterfitt

20070154903 - Selective isolation and concentration of nucleic acids from complex samples: The present invention provides methods for detecting a target nucleic acid molecule in a sample that comprises nucleic acid molecules of higher biological complexity than that of amplified nucleic acid molecules in a complex environment containing numerous non-nucleic acid components. In particular, the present invention provides methods and probes for... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070154909 - Signal-on architecture for electronic, oligonucleotide-based detectors: The invention provides a general “signal-on” architecture for oligonucleotide-based detectors that leads to order of magnitude increases in signal gain and sensitivity as compared to prior art detectors. The detectors of the invention rely on base pairing between two oligonucleotide strands, the sensor strand and the blocker strand. In the... Agent: Foley & Lardner LLP

20070154896 - System and method for identification of microrna target sites and corresponding targeting microrna sequences: A method for determining whether a nucleotide sequence contains a microRNA binding site and which microRNA will bind thereto is provided. For example, in one aspect of the invention, a method for determining whether a nucleotide sequence contains a microRNA binding site and which microRNA sequence will bind thereto is... Agent: Ryan, Mason & Lewis, LLP

20070154901 - Trimerising module: The present invention relates to the design of trimeric polypeptides using polypeptide structural elements derived from the tetranectin protein family, and their use in rational de novo design and production of multi-functional molecules including the application of the multi-functional molecules in protein library technology, such as phage display technology, diagnostic... Agent: Roberts, Mlotkowski & Hobbes

20070154951 - Biosensor apparatus and method with sample type and volume detection: A biosensor apparatus and method with sample type and cell volume detection. The apparatus includes a sine wave generator to apply an AC signal to a biosensor cell containing a sample, a current-to-voltage converter, a phase shifter, a square wave generator, a synchronous demodulator, and a low pass filter which... Agent: Carol Lasalle, Bozicevic, Field & Francis LLP

20070154947 - Chemical biodiscriminator: In one embodiment the invention provides a mutant UDP-glucose receptor (P2Y14) functionally expressed in the yeast Saccharomyces. The mutant receptors have ligand-binding properties that are useful as practical biosensors. Mutagenesis of the entire UDP-glucose receptor gene yielded receptors with increased activity but similar ligand specificities, while random mutagenesis of residues... Agent: Medlen & Carroll, LLP

20070154952 - Expanding the eukaryotic genetic code: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic... Agent: Quine Intellectual Property Law Group, P.C.

20070154944 - Fraction comprising guinea pig immunoglobulin e and antibody: Provided are a guinea pig immunoglobulin E fraction separated and purified from blood of an allergen-sensitized guinea pig, a highly specific anti-guinea-pig immunoglobulin E antibody obtained using the fraction as the antigen, and a reagent for immunoassaying guinea pig immunoglobulin E comprising the antibody.... Agent: Leydig Voit & Mayer, Ltd

20070154945 - Immobilized biomolecule and method of detecting substance capable of interacting with biomolecule: It is an object of the present invention to provide a method of conveniently efficiently and easily immobilizing a protein on a substrate, a method of detecting a substance capable of interacting with the protein at a high sensitivity, and a protein and a protein-immobilized substrate which are used in... Agent: Knobbe Martens Olson & Bear LLP

20070154946 - Massively parallel synthesis of biopolymeric arrays: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a... Agent: Blakely Sokoloff Taylor & Zafman

20070154950 - Method of quickly detecting and/or assaying antigen by fluorescence correlation spectrometry: The present invention provides a method of quickly and accurately detecting and/or assaying an antigen using fluorescence correlation spectroscopy (FCS), which involves a fluorescence-labeled antibody fragment and a non-fluorescence-labeled intact antibody that form a complex with the antigen. There is a significant difference in diffusion rate between the fluorescence-labeled antibody... Agent: Frommer Lawrence & Haug

20070154949 - Monoclonal antibody specific to truncated midkine (tmk) protein and uses thereof: The present invention relates to a monoclonal antibody or a fragment thereof specific to truncated Midkine (tMK) protein, hybridoma producing the monoclonal antibody, a method of detecting truncated Midkine protein (tMK) by use of the monoclonal antibody, a method of detecting a tumor cell, and a kit containing the monoclonal... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070154948 - Novel antibacterial agents: This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved... Agent: Theravance, Inc.

20070154959 - Assay system for glp-2 receptor ligands: Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue.... Agent: Connolly Bove Lodge & Hutz LLP

20070154957 - Cell division marker: This application relates to a newly identified animal cell structure, the midbody scar. This structure is a remnant of the midbody that is retained by one daughter cell following cytokinesis and persists through multiple subsequent cell cycles. The midbody scar can be useful as a marker of dividing cells or... Agent: Fish & Richardson PC

20070154956 - Co-culture lymphoid tissue equivalent (lte) for an artificial immune system (ais): The present invention relates to methods for preparing an artificial immune system. The artificial immune system comprises a cell culture comprising T cells, B cells and antigen-primed dendritic cells. The artificial immune system of the present invention can be used for in vitro testing of vaccines, adjuvants, immunotherapy candidates, cosmetics,... Agent: Merchant & Gould PC

20070154954 - Fluorescence polarization assay: Disclosed are methods and systems that use fluorescence polarization to identify compounds that have the ability to bind to, and/or modulate, the activity of the Receptor for Advanced Glycated Endproducts (RAGE). Compounds identified using the methods and systems of the present invention may comprise small organic molecule RAGE antagonists. The... Agent: Kilpatrick Stockton LLP - 41305 Charles Calkins

20070154953 - Identification of antigen epitopes: The present invention relates to methods for identifying and/or detecting T-cell epitopes of a protein antigen, to methods for preparing peptide vaccines against a protein antigen, to methods for controlling the quality of receptor/ligand complexes and/or their components, to methods for preparing nanoparticles having at least one immobilized receptor unit... Agent: Ostrolenk Faber Gerb & Soffen

20070154960 - Method for assessing disease states by profile analysis of isolated circulating endothelial cells: Elevated number of Circulating Endothelial Cells (CEC) have been implicated in disease conditions associated with the formation or destruction of blood vessels such as acute coronary syndrome, thrombocytopenic purpura, sickle cell disease, sepsis, lupus, nephrotic syndromes, rejection of organ transplants, surgical trauma and cancer. This invention provides a method for... Agent: Immunicon Corporation

20070154955 - Method of diagnosing autoimmune polyglandular syndrome and kits thereof: A method of diagnosing autoimmune polyglandular syndrome (APS) in a subject, and a kit for identifying a subject having autoimmune polyglandular syndrome (APS) are provided.... Agent: Birch Stewart Kolasch & Birch

20070154958 - Multiplex in situ immunohistochemical analysis: A method of in situ immunohistochemical analysis of a biological sample is provided. The method allows for the multiplex and simultaneous detection of multiple antigens, including multiple nuclear antigens, in a tissue sample.... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20070154961 - Cell separation compositions and methods: The invention provides compositions and methods for cell separation. These reagents and techniques specifically agglutinate cells via surface antigen recognition and can be used to recover even rare cell types in high yield.... Agent: Fish & Richardson P.C.

20070154965 - Chlorotoxin-labeled nanoparticle compositions and methods for targeting primary brain tumors: Chlorotoxin-labeled nanoparticles that target primary brain tumors, compositions that include the nanoparticles, methods of imaging tissues using the nanoparticles, and methods for treating tissues using the nanoparticles.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20070154963 - Method to determine whether a compound is a cellular gstpi inhibitor: A method to determine whether a compound is a cellular GSTπ inhibitor.... Agent: Foley & Lardner LLP

20070154964 - Methods for diagnosing and treating prostate cancer: Methods for diagnosing and treating prostate cancer are disclosed. In practicing the method, a subject's body-fluid sample is assayed for GPC3 protein, and the GPC3 level observed is used in determining whether the subject has an elevated GPC3 level associated with prostate cancer. Patients with such elevated levels may be... Agent: Perkins Coie LLP

20070154972 - 5-fluoro-uracil immunoassay: Novel conjugates of 5-fluoro-uracil and novel 5-fluoro-uracil immunogens and monoclonal antibodies generated by these immunogens which are useful in immunoassays for the quantification and monitoring of 5-fluoro-uracil in biological fluids.... Agent: Gibbons P.C.

20070154971 - Agents that bind to and inhibit human cytochrome p450 2c19: The invention provides monoclonal antibodies and other binding agents to human cytochrome P450 2C19 having advantageous properties, including capacity substantially to inhibit enzyme activity of human cytochrome P450 2C19 and lack of specific binding to other human cytochrome P450s. The binding agents of the invention are useful inter alia in... Agent: Townsend And Townsend And Crew, LLP

20070154966 - Assay for the detection of rapamycin and rapamycin analogs: The present application discloses an assay and a kit for quantification of rapamycin in various samples.... Agent: Nath & Associates

20070154967 - Chemiluminescence sensor array: Embodiments of the invention relate to integrated chemiluminescence devices and methods for monitoring molecular binding utilizing these devices and methods. These devices and methods can be used, for example, to identify antigen binding to antibodies. The devices include both a chemiluminescence material and a detector integrated together.... Agent: Morrison & Foerster LLP

20070154968 - Method of diagnosing myasthenia gravis and kits therefor: The present invention relates to methods of diagnosing myasthenia gravis in a subject, by determining an amount of at least one autoantibody that specifically binds one or more autoantigens selected from heat-shock protein 60 (hsp60), heat-shock protein 90, alpha isoform (hsp90α), and heat-shock protein 90, beta isoform (hsp90β). The invention... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070154970 - Methods for monitoring the status of assays and immunoassays: The invention relates in part to the use of independent assay controls (IACs) for the optical communication between an assay device and an instrument in monitoring and performing assays, preferably immunoassays.... Agent: Foley & Lardner LLP

20070154969 - Sandwich immunoassay and monoclonal antibodies for comp, cartillage oligomeric matrix protein: The present invention provides a new sensitive direct sandwich assay for determining the presence of COMP in a clinical sample. Two monoclonal antibodies directed against separate antigenic determinants of the COMP molecules are used in the assay. The invention also relates to three particularly advantageous monoclonal antibodies per se that... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070154973 - Hygiene monitoring: A test device for hygiene monitoring by detecting glucose as an indication of the presence of biological material.... Agent: Charm Sciences, Inc.

20070154974 - Analytical method for detecting alkaline sphingomyelinase and kit for use in such method: An analytical fluorometric method and a kit for use in such method are disclosed for assessing the presence of alkaline sphingomyelinase (SMase) in the stool of a patient in need of such an assessment since alkaline SMase is a marker of serious pathological states, such as colon cancer.... Agent: Nixon & Vanderhye, PC

20070154975 - Chromogenic tests in the presence of cells: The present invention concerns a method for the colorimetric measurement of enzyme activities comprising the following steps: preparing a cell suspension or a cell lysate containing cell components adding a chromogenic substrate at the start of the enzyme reaction adding a first additional substance to stop the enzyme reaction colorimetric... Agent: Roche Diagnostics Operations Inc.

20070154976 - Method of determining substrate contained in hemoglobin-containing sample: The present invention provides a convenient, efficient method for determining a substrate contained in a hemoglobin-containing sample and a reagent therefor, which can be employed for a variety of automatic analyzers while reducing interference of hemoglobin contained in the sample. A method for determining a substrate contained in a hemoglobin-containing... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070154977 - Methods and compositions of enzymatic cycling based assays for myeloperoxidase: The present invention provides a method for assaying myeloperoxidase activity. In the assay, a sample containing myeloperoxidase or suspected of containing myeloperoxidase is contacted with substrate including serine, hydrogen peroxide, and a halide. If myeloperoxidase is present in the sample, serine is converted into glycolaldehyde, which is further converted into... Agent: Morrison & Foerster LLP

20070154978 - Method and device for detecting biologically active substances: This application claims a method for detecting biologically active substances, comprising the following steps a) providing a support carrying substances to be tested b) providing a suspension containing luminescent microorganisms, c) coating the support with the suspension of microorganisms, d) detecting the biologically active substances on the support by detecting... Agent: Jeffrey M. Greenman

20070154979 - Method of measuring lipoarabinomannan and application thereof: A method for measuring LAM and a method for detecting an acid-fast bacterium, which comprise at least a step of allowing a Limulus reagent to contact with a LAM-containing sample, a method for removing reactivity of LAM with a Limulus reagent, which comprises at least a step of allowing a... Agent: Sughrue Mion, PLLC

20070154980 - Fluorescent dyes: m

20070154990 - Assays for identifying inhibitors of fatty acid amide hydrolase: Assays for screening compounds suspected of binding fatty acid amide hydrolase (FAAH) using scintillation proximity assay (SPA) technology are described. The assays utilize the interactions of reversible inhibitors such as [3H]—R(+)-methanandamide (MAEA) and membrane-associated FAAH, such as FAAH-containing microsomes, to evaluate the displacement activity of candidate FAAH inhibitors. The assays... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20070154988 - Bacillus host cell: A Bacillus licheniformis mutant host cell derived from a parent B. licheniformis host cell, which mutant host cell is mutated in one or more gene(s) encoding one or more polypeptide(s) involved in sporulation which is at least 80% identical to one or more of the polypeptides shown in SEQ ID... Agent: Novozymes North America, Inc.

20070154984 - Definitive endoderm: Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.... Agent: Knobbe Martens Olson & Bear LLP

20070154987 - Fungus-induced inflammation and eosinophil degranulation: This document relates to methods and materials involved in fungus-induced inflammation and eosinophil degranulation. For example, isolated nucleic acids encoding fungal polypeptides, fungal polypeptides, methods for assessing fungus-induced inflammation, methods for assessing eosinophil degranulation, and methods for identifying inhibitors of fungus-induced inflammation and/or eosinophil degranulation are provided.... Agent: Fish & Richardson P.C.

20070154981 - Insulin-producing cells derived from stem cells: The disclosure provides, among other things, insulin-producing cells derived from stem cells, such as human stem cells and neural stem cells. The disclosure discloses a relationship between caudalizing factors and the differentiation of insulin-producing cells.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070154982 - Mammalian cell lines modified for the production of recombinant glycoproteins: Novel, genetically modified mammalian cell lines are described, which can produce glycoconjugates the oligosaccharide portions of which are more similar to the human one than those of the same glycoconjugates produced by cells which have not been genetically modified. The lines in question can be used for the production of... Agent: Darby & Darby P.C.

20070154991 - Method for overexpression of zwitterionic polysaccharides: The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular... Agent: Wolf Greenfield & Sacks, P.C.

20070154985 - Method for the recombinant expression of an n-terminal fragment of hepatocyte growth factor: A method for the production of a-chain of hepatocyte growth factor or an N-terminal fragment thereof (NK polypeptide) by expression of a nucleic acid encoding said NK polypeptide in a microbial host cell, isolating of inclusion bodies containing said NK polypeptide in denatured form, solubilization of the inclusion bodies and... Agent: Hoffmann-la Roche Inc. Patent Law Department

20070154983 - Methods of in vitro protein synthesis: Improved methods are provided in vitro synthesis of biological molecules, providing for improved yields, lowered costs, and enhanced utility. Improved yield and lowered cost is obtained by the use of a phosphate free energy source in the presence of exogenous phosphate, and optionally in the absence of exogenous nucleoside triphosphates.... Agent: Bozicevic, Field & Francis LLP

20070154986 - Streptococcus pneumoniae polynucleotides and sequences: The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media,... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070154989 - Zinc finger domains specifically binding agc: Polypeptides that contain zinc finger-nucleotide binding regions that bind to nucleotide sequences of the formula AGC are provided. Compositions containing a plurality of polypeptides, isolated heptapeptides possessing specific binding activity, polynucleotides that encode such polypeptides and methods of regulating gene expression with such polypeptides, compositions and polynucleotides are also provided.... Agent: Catalyst Law Group, Apc

20070154992 - Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants: The present invention relates to protease resistant mutants of human growth hormone, which contain newly introduced proteolysis resistant mutations and N-linked or O-linked glycosylation site(s), such that these recombinantly produced polypeptides have glycosylation patterns distinctly different from that of the naturally occurring human growth hormone. The polynucleotide coding sequences for... Agent: Morgan, Lewis & Bockius LLP (sf)

20070154993 - Enhancing recombinant hemoglobin production by co-expression with alpha hemoglobin stabilizing protein: The present disclosure relates to the use of AHSP to stabilize the α subunit of rHb. AHSP may be co-expressed with the hemoglobin genes. AHSP stabilization may be used to increase the production of intact rHb in various systems, such as E. coli, other microorganisms, or animal erythroid cells. This... Agent: Baker Botts L.L.P. Patent Department

20070154994 - Coiled-coil fusion proteins comprising cell receptor domains: Fusion proteins and coiled-coil induced dimers prepared from both the ectodomains and the kinase domains are disclosed. The receptor domains when presented in the form of a homodimer or heterodimer by virtue of the coiled-coil tag have enhanced ligand binding activity or enhanced kinase activity. The kinetics of binding and... Agent: Perkins Coie LLP

20070154995 - Development of human monoclonal antibodies and uses thereof: The present invention provides a heteromyeloma cell other than B6B11, capable of producing a trioma cell when fused with a human lymphoid cell, wherein the trioma cell is capable of producing a tetroma cell capable of producing a monoclonal antibody having specific binding affinity for an antigen, when fused with... Agent: John P. White Cooper & Dunham LLP

20070154996 - Method for transferring a glucosyl residue: An object of the present invention is to provide novel methods for forming glucosyl-transferred polyalcohols, glucosyl-transferred glucuronic acid, and glucosyl-transferred derivatives of glucose whose C-6 hydroxyl group bound to a saccharide by using an enzymatic reaction. The present invention solves the above object by providing a method for transferring a... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070154997 - Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from comamonas testosteroni 5-mgam-4d and recombinant organisms expressing those enzymes useful for the production of amides and acids: The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitriles to the corresponding amides, and the amidase is useful for hydrolysis of amides to... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070154998 - Process for the preparation of vitamin k2: A process for the preparation of vitamin K2 (MK-7) comprising the culture of Bacillus subtilis mutant strain GN13/72-DSM 17766 deposited on Dec. 5, 2005 at the DSMZ.... Agent: Arent Fox PLLC

20070154999 - Succinic acid - producing bacterium and process for producing succinic acid: Succinic acid is produced by using a coryneform bacterium which has succinic acid-producing ability and has been modified so that an activity of pyruvate oxidase is decreased.... Agent: Greenblum & Bernstein, P.L.C

20070155000 - Ethanol productivities of saccharomyces cerevisiae strains in fermentation of dilute-acid hydrolyzates depend on their furan reduction capacities: The present invention relates to an ethanol producing microbial strain, such as Saccharomyces cerevisiae strain, being able to grow and produce ethanol from lignocellulosic hydrolysates comprising growth inhibiting compounds of the group furfural and 5-hydroxy-methyl furfural, in a batch, fed-batch or continuous fermentation, said microbial strain being tolerant to such... Agent: Gauthier & Connors, LLP

20070155001 - Secondary liquefaction in ethanol production: The invention relates to a method of producing ethanol by fermentation, said method comprising a secondary liquefaction step in the presence of a thermostable acid alpha-amylase or a thermostable maltogenic acid alpha-amylase.... Agent: Novozymes North America, Inc.

20070155002 - Amino acid sequence from active principles in musk and their acetic salts, preparation and use thereof: The present invention provides amino acid sequences obtained from the active principles in Chinese traditional medicine musk, such as SDSECPLLCEVWILK, SDSECPLLPRQGTGSLH, IDCECPLLEAKCPSFPLWPQGREEERQ, SDSECPLLLNGTNTSSRFESINCVFLSTEEGC and their acetic salts. The preparation of the amino acid sequences and their use as anti-inflammatory medicines or immunity inhibitors are also disclosed by this invention.... Agent: Trask Britt

20070155003 - Lipase powder, method for manufacture thereof, and use thereof: There is provided a lipase powder which is a granulated material comprising a lipase and at least one member selected from the group consisting of fatty acids having 8 to 12 carbon atoms, alcohol esters thereof, and a mixture thereof. This lipase powder has an increased lipase activity.... Agent: Buchanan, Ingersoll & Rooney PC

20070155004 - Treatment of crystals in order to avoid light-induced modifications of the refractive index: A method for the treatment of a crystal, such as a lithium niobate crystal or lithium tantalate crystal, having nonlinear optical properties. The crystal comprises foreign atoms which bring about specific absorption of radiated light. The foreign atoms are transformed into a lower valent state by means of oxidation. Electrons,... Agent: Darby & Darby P.C.

20070155005 - Chemical biological device for display and light emission: m

20070155006 - Photobioreactor: An invention proposes a construction of a photobioreactor, which is based on application of parallel sets of multi-level troughs intended for flowing a microalgae suspension, these troughs are irradiated therewith by the sun light. The troughs are arranged in each set one above the other horizontally or with a small... Agent: Alexander Levin

20070155007 - High throughput cell-based assays fabricated with integrated silicon and cell culture technologies: The present invention relates to articles and methods involving porous materials (e.g., membranes) which may interact with species, such as biological molecules, cells, etc., whereby the species may adhere to or become immobilized with respect to a surface of the porous material or an adhesion layer coating the porous surface.... Agent: Wolf Greenfield & Sacks, P.C.

20070155008 - Method for the production and purification of adenoviral vectors: The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have... Agent: Marshall, Gerstein & Borun LLP

20070155009 - Extracellular matrix components for expansion or differentiation of hepatic progenitors: A method is provided of propagating hepatic progenitors in vitro on or in one or multiple extracellular matrix components found in the stem cell compartment or niche of liver. A container for the propagation of the progenitors and comprising culture dishes, bioreactors, or lab chips.... Agent: Foley And Lardner LLP Suite 500

20070155010 - Highly porous self-cohered fibrous tissue engineering scaffold: The present invention is directed to bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting proportionally increased mechanical strength in one or more directions. The web materials often possess a high degree of loft. The web materials can... Agent: Gore Enterprise Holdings, Inc.

20070155011 - Method of producing stable collagen producing mesenchymal cells from adult adipose stem cells via transfection: The present invention provides a method for producing a structurally stable collagen producing mesenchymal pre-adipocyte stem cell and the cells derived therefrom by obtaining fat stem cells from a patient; centrifuging and washing the fat stem cells, culturing the fat stem cells and suspending them in media together with mesenchymal... Agent: James G. O'neill Klein, O'neill & Singh LLP

20070155012 - Method for production of neurons from cells of a cell line: The invention relates to a method for production of neurons from cells of a cell line which may be differentiated to produce neurons in particular, whereby said cells are cultivated in spheres, preferably by exposing the same to growth factors, such as, for example, EGF (epidermal growth factor) and/or bFGF... Agent: Egbert Law Offices

20070155014 - Methods for increasing efficiency of homologous recombination: Methods and compositions for increasing or decreasing homologous recombination activity in a eukaryotic cell are provided. More particularly, various methods and compositions are provided which decrease the level of non-homologous recombination in a cell and thereby increase the frequency of targeted homologous recombination events. Various compositions including cells and kits... Agent: Alston & Bird LLP

20070155013 - Pluripotent stem cell growing method: A novel growing method is provided for pluripotent stem cells such as ES cells. The method of the invention is a pluripotent stem cell growing method and gene transfer method in which pluripotent stem cells are cultured under conditions that maintain their undifferentiated state and pluripotency, the method being characterized... Agent: Hunton & Williams LLP Intellectual Property Department

20070155015 - Biochip electroporator and its use in multi-site, single-cell electroporation: The introduction of genetic material or molecules of biological interest into cells is a procedure with an increasing interest both for experimental and application purposes, so that electroporation is a widely used technique, but the electroporation of single adhering cells is still impaired. The present application describes an apparatus for... Agent: Lorusso & Associates

20070155016 - Method and apparatus for integrated cell handling and measurements: Method and systems provide improved cell handling in microfluidic systems and devices using lateral cell trapping and methods of fabrication of the same that allow for selective low voltage electroporation and electrofusion.... Agent: Quine Intellectual Property Law Group, P.C.