Chemistry: molecular biology and microbiology inventions 06/07

20070148636 - Method, compositions and kits for preparation of nucleic acids: Methods, compositions and kits are provided for labeling, copying and/or amplifying nucleic acids. The methods, compositions and kit can be used for a variety of applications, for example, genome-wide scanning applications such as CGH or location analysis.... Agent: Agilent Technologies Inc.

20070148670 - Methods for detecting conformational changes in bioentities: Described herein are methods for detecting conformational changes in bioentities.... Agent: Corning Incorporated

20070148658 - Systems and methods for biopolymeric probe design using graphical representation of a biopolymeric sequence: Systems and methods for using the same to obtairi one or more probe sequences in response to an input graphical representation of a biopolymeric sequence are provided. Also provided are computer program products for executing the subject methods.... Agent: Agilent Technologies Inc.

20070148719 - Bioassay element and its producing method: The present invention relates to a bioassay element and its producing method. The bioassay element includes a carrier, a testing material, and a coating film, in which the testing material is dispersed in the coating film which covers on the surface of the carrier and comprises a casein and calcium... Agent: Birch Stewart Kolasch & Birch

20070148723 - Method and apparatus for detecting presence of toxic material within sample: Provided is a method for detecting the degree of toxicity of toxic materials within a sample. The method includes contacting sub-mitochondrial particles having competent mitochondrial enzyme formed from the inner membranes of mitochondria, an electron donor which transmits electrons to the electron transfer system of the sub-mitochondrial particles, and a... Agent: Cantor Colburn, LLP

20070148628 - Organ preservation and/or perfusion: The present invention relates to a solution for preservation, perfusion, and/or reperfusion of an organ, especially the heart, for transplantation. The solution contains peptide inhibitor(s) of protein kinase C ε (PKC ε). Methods for using the inventive solution are also disclosed, including methods for preserving an organ for transplantation, for... Agent: Blank Rome LLP

20070148629 - Composition for the preservation of viruses: The present invention relates to a composition for the preservation of a virus, the composition including a virus, a lipid and a cryoprotectant.... Agent: Birch Stewart Kolasch & Birch

20070148630 - Removal of adenine during a pathogen reduction process in whole blood or red blood cells by dilution: The methods of this invention involve preventing the formation of a complex between adenine and riboflavin by reducing the amount of adenine in a solution containing blood or blood components to be pathogen reduced.... Agent: Gambro, Inc Patent Department

20070148634 - Cells having a spectral signature and methods of preparations and use thereof: Methods, compositions and articles of manufacture for encoding a cell with semiconductor nanocrystals and/or other fluorophors are provided. The encoded cells can be subjected to functional assays in mixed populations, and an assay result can be determined and associated with individual cells by virtue of their code. The methods are... Agent: Invitrogen Corporation C/o Intellevate

20070148633 - Dielectric properties models and methods of using same: Disclosed herein are dielectric properties models that are designed to enable simulated use testing by medical device companies, medical device designers, individual inventors, or any other entity interested in the performance of medical devices. These models are unique in possessing a level of correlation to dielectric properties of human or... Agent: Beusse Wolter Sanks Mora & Maire

20070148632 - Levenberg-marquardt outlier spike removal method: Systems and methods for identifying and removing spikes in data sets representing PCR growth curves or other sigmoid type curves or growth curves. A double sigmoid function with parameters determined using a Levenberg-Marquardt regression algorithm is used to find an approximation to the curve, and a statistical test such as... Agent: Townsend And Townsend And Crew, LLP

20070148631 - Methods and apparatus for screening for chromosomal abmormalities: This invention generally relates to methods, apparatus, and computer program code for antenatal screening for chromosomal abnormalities, in particular Down's Syndrome. A method of determining a likelihood of a fetus carried by a pregnant mother having a chromosomal abnormality, a first biological, parameter being suitable for screening said fetus for... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20070148635 - Immobilized carbohydrate biosensor: A biosensor in which a carbohydrate or a derivative of a carbohydrate is used to generate a detectable signal by way of the specific binding to a protein, a virus or a cell.... Agent: Smith, Gambrell & Russell

20070148638 - Method for detecting low concentrations of a target bacterium that uses phages to infect target bacterial cells: The invention is directed to a method for detecting low concentrations of bacteria in liquid solution that may or may not be complex liquid solutions. In one embodiment, immunomagnetic separation (IMS) is used to separate target bacterium that may be in a liquid mixture from other constituents in the mixture.... Agent: Christopher J. Kulish, Esq

20070148639 - Methods and devices for nucleic acid amplification on a surface: Described are methods and devices for immobilizing primers on the surface of a microarray with polymer linkers. Nucleic acid amplification and total analysis without the necessity of polymerase chain reaction may be accomplished with the disclosed methods and devices.... Agent: Trask Britt

20070148640 - Methods and kits for decreasing interferences in plasma or serum containing assay samples of specific binding assays: Methods and kits are provided for decreasing interferences and inaccuracies due to nonoptimal sample handling of blood samples in plasma or serum containing assay samples of specific binding assays by addition of a large polycation to the assay sample during the specific binding assay.... Agent: Robert Deberardine Abbott Laboratories

20070148637 - Species-specific probes for identification of target virus and identification method using said probes: The inventions provides a method for identifying a target virus in an infected subject comprising the steps of designing a pair of degenerate primers corresponding to highly conserved regions of the target virus; designing a pair of species-specific primers according to highly variable sequences within the conserved regions of the... Agent: Akin Gump Strauss Hauer & Feld L.L.P.

20070148690 - Analysis of gene expression profiles using sequential hybridization: This invention relates generally to analysis of gene expression profiles. In particular, the present invention provides a method for a method for analyzing gene expression profiles of a cell, which method comprises: a) providing for isolated mRNA or cDNA target sequences from a cell; b) sequentially hybridizing said isolated mRNA... Agent: Morrison & Foerster LLP

20070148683 - Annealing control primer and its uses: The present invention relates to an annealing control primer for improving annealing specificity in nucleic acid amplification and its applications to all fields of nucleic acid amplification-involved technology. The present primer comprises (a) a 3′-end portion having a hybridizing nucleotide sequence substantially complementary to a site on a template nucleic... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070148685 - Capture, concentration and quantitation of abnormal prion protein from biological fluids using depth filtration: Methods for producing biological solutions such as immunoglobulins and in particular anti-D immunoglobulin substantially free of abnormal prion protein resulting therefrom. Specifically provided are methods for aggregation of prions and depth filtration of the biological solution to capture and remove abnormal and if desired, normal prion protein. The prion protein... Agent: Philip S. Johnson Johnson & Johnson

20070148649 - Cartridge for nucleic acid separation and purification and method for producing the same: A cartridge for nucleic acid separation and purification and a method for producing the cartridge are provided which does not require a special facility for adhering containers and can produce a number of cartridges at the same time. Also is provided a cartridge for nucleic acid separation and purification in... Agent: Sughrue Mion, PLLC

20070148689 - Compositions and methods for the prevention, treatment and detection of tuberculosis and other diseases: Methods and compositions are provided for the prevention and treatment of infectious diseases such as syphilis, tuberculosis, pneumonia, other bacterial infections, AIDS, and other viral infections. Many of the compositions are active against carbon monoxide dehydrogenase (“CODH”), and include substances such as antigens, antibodies specific for CODH, and other inhibitors... Agent: Novak Druce & Quigg, LLP

20070148680 - Detection of disease related genes: The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives, or substances recognized by the protein synthesizing... Agent: Peter G. Carroll Medlen & Carroll, LLP

20070148678 - Device and method for carrying out a nucleic acid test, and method for producing such a device: A device and a method are disclosed for carrying out nucleic acid tests. The device includes a substrate and one or more gel pads arranged on the substrate and designed so that at least one of the biological and chemical reactions necessary for the test takes place in them, particularly... Agent: Harness, Dickey & Pierce, P.L.C

20070148666 - Diagnosis and treatment of brain cancer: Certain genes are silenced in medulloblastoma. These genes include WIF1, sFRP1 and Dkk1. By detecting the expression of at least one of these genes, it is possible to diagnose cancer or to determine whether the cancer is recurring after treatment. Diagnostic methods, methods of treatment, and kits are provided.... Agent: Viksnins Harris & Padys Pllp

20070148671 - Dna polymerase fusions and uses thereof: The present invention discloses methods of using DNA polymerase fusions at high pH in PCR, DNA sequencing and mutagenesis protocols.... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070148663 - Eb1-related compositions and methods: This invention provides an isolated polypeptide comprising all or a portion of the c-terminal domain of EB1, wherein the isolated polypeptide does not consist of residues 150-268, 219-268 or 185-268 of SEQ. ID. NO:2. This invention further provides related compositions, nucleic acids, cells and methods.... Agent: Cooper & Dunham, LLP

20070148653 - Fine metal structure, process for producing the same, fine metal mold and device: A fine metal structure having its surface furnished with microprojections of high strength, high precision and large aspect ratio; and a process for producing the fine metal structure free of defects. There is provided a fine metal structure having its surface furnished with microprojections, characterized in that the microprojections have... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070148679 - Gene set used for examination of colon cancer: Colon cancer cells in a sample are screened by analyzing the amount of expression of at least 2 or more genes or products thereof selected from the group of genes listed in Tables 1 and 30. As compared to conventional method, patients having colon cancer can be detected with higher... Agent: Fitzpatrick Cella Harper & Scinto

20070148681 - Gene synthesis kit: This disclosure is directed to the field of polynucleotide synthesis, and the embodiments taught herein are generally directed to a kit for use in the design of a desired polynucleotide from information obtained from a polypeptide or another polynucleotide, the generation of a custom set of oligonucleotides that complement the... Agent: Perkins Coie LLP

20070148668 - High-throughput assay of hematopoietic stem and progenitor cell proliferation: The present invention relates generally to assays, methods, and kits that provide reagent mixes and instructions for determining the proliferative status of isolated target cell populations. The methods measure the luminescent output derived from the intracellular ATP content of incubated target cells, and correlate the luminescence with the proliferative status... Agent: Rosenbaum & Associates

20070148684 - Immunoassay for hiv protease inhibitors: A non-isotopic immunoassay for an HIV protease inhibitor comprising incubating a sample containing the inhibitor with a receptor specific for the inhibitor or for a metabolite of said inhibitor and further with a conjugate comprising an analog of the inhibitor and a non-isotopic signal generating moiety. Signal generated as a... Agent: Roche Diagnostics Operations Inc.

20070148650 - Isolation of nucleic acid from mouth epithelial cells: The present invention is directed to a scraping instrument for collection of a biological sample, and a non-invasive method for obtaining nucleic acid from buccal mucosa epithelial cells using the scraping instrument. Such nucleic acid can be used for example for gene expression profiling, including to assess lung disease risk... Agent: Ronald I. Eisenstein

20070148692 - Kcnq potassium channels and methods of modulating same: The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present... Agent: Louis J. Wille Bristol-myers Squibb Company

20070148655 - Leucine rich repeat containing protein: This invention relates to the novel protein, termed INSP (179), herein identified as a secreted protein, in particular as a member of the leucine rich repeat containing protein family and to the use of this protein and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070148657 - Low volume hybridization: The present document relates to a system and method of commingling a low volume of a target solution with an array. For example, a quantity of the target solution and a quantity of an immiscible liquid may be introduced into a cavity having an array on an interior surface. The... Agent: Agilent Technologies Inc.

20070148661 - Lsamp gene associated with cardiovascular disease: The LSAMP gene can be used for cardiovascular disease risk assessment, in particular Left Main Disease. The genetic risk attributable to LSAMP adds to known cardiovascular disease risk factors. Assessment of risk attributable to LSAMP permits early initiation of preventive and therapeutic strategies. Given the pronounced clinical risk associated with... Agent: Banner & Witcoff, Ltd.

20070148651 - Method and kit for the isolation of rna: The present invention relates to a method and a kit for the isolation of RNA in the presence of DNA. The isolation is carried out by binding to a magnetite solid phase, where the binding buffer produces a concentration of guanidinium thiocyanate of>2.5 mol/l, and a certain concentration of phosphate... Agent: Millen, White, Zelano & Branigan, P.C.

20070148665 - Method for automatically detecting spots on a substrate: An apparatus and method for imaging metallic nanoparticles is provided. Preferably, the invention provides for an apparatus and method for detection of gold colloid particles and for accurate reporting to the operator. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module,... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070148642 - Method for detecting gene specifying allergic predisposition: A method of detecting genes which comprises detecting gene polymorphisms in allergy-predisposition-related genes; i.e., interleukin 12 receptor IL-1 β2 chain and β1 chain genes, interleukin 18 receptor α chain gene, interferon γ receptor 1 chain gene and interleukin 12.p40 subunit gene, to thereby detect allergic predisposition. Use of the present... Agent: Sughrue Mion, PLLC

20070148656 - Method for detecting the risk of cancer, coronary heart disease, and stroke by analysing a catalase gene: The present invention relates to variants in the catalase gene. The invention provides a method of identifying subject's susceptibility or predisposition to or risk of developing cancer, cancer death, CHD, and/or cerebrovascular stroke by detecting gene polymorphisms and other gene mutations in a biological sample from the subject. The invention... Agent: Birch Stewart Kolasch & Birch

20070148648 - Method for distinguishing who classified aml subtypes: Disclosed is a method for distinguishing WHO classified AML subtypes AML_MLL, t(15;17), t(8;21), inv(16), 11q23, de novo_AML, s_AML, t_AML, AML_M0, AML_M1, AML_M2, AML_M4, AML_M5a, AML_M5b, AML_M6, AML_t(15;17)/M3 and/or AML_t(15;17)/M3v in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the... Agent: Roche Molecular Systems Inc Patent Law Department

20070148644 - Method for the detection of cancer: A method for the early diagnosis, prognosis or clinical monitoring of cancer disease based on the quantitation of DNA in a plasma sample from a cancer patient, a subject with cancer susceptibility or an individual at risk of developing cancer.... Agent: Birch Stewart Kolasch & Birch

20070148641 - Method of screening for drug hypersensitivity reaction: Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for polymorphisms in the TNFα gene, the class 1 HLA genes, or a combination of both the TNFα and HLA genes.... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B475

20070148667 - Methods and computer software for detecting splice variants: Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070148677 - Methods and systems for acquiring real-time quantitative melt data: Described are methods and systems for acquiring real-time quantified melt data. A first Double-stranded nucleic acid are immobilized on a support. The temperature of the double-stranded nucleic acids is slowly ramped up until the double-stranded nucleic acids melt. Differences in fluorescence emission are used to signal when the melt occurred.... Agent: Trask Britt

20070148676 - Methods for detecting gene expression in peripheral blood cells and uses thereof: The present invention relates to methods of identifying biomarkers for disease by measuring gene expression levels in subpopulations of blood cells obtained from subjects of closed populations. Particularly, the present invention relates to methods of diagnosing, monitoring and prognosing diseases by determining expression levels of disease-specific genes.... Agent: Winston & Strawn LLP Patent Department

20070148646 - Methods for relatvie quantification of specific nucleic acid sequences: This invention relates generally to a method for quantifying the number of occurrences of a specific nucleic acid sequence within a nucleic acid sample in order to circumvent the shortcomings of the methods currently available and to provide reliable quantification of a specific nucleic acid sequence within a nucleic acid... Agent: David S Resnick Nixon Peabody

20070148669 - Modified tumor necrosis factor-alpha converting enzyme and methods of use thereof: The present invention discloses a modified tumor necrosis factor-alpha converting enzyme (TACE) catalytic domain, that unlike the native TACE catalytic domain, is stable at high protein concentrations. The present invention further discloses methods for generating crystals of the modified TACE protein in protein-ligand complexes with a number of inhibitors. In... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070148664 - Modulation of skin color: The invention provides a collection of polymorphic sites associated with variations in human skin color, and genes containing or proximal to the sites.... Agent: Townsend And Townsend And Crew, LLP

20070148673 - Novel chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070148688 - Novel human enzymes of the metalloprotease family: This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are useful in therapy, to antibodies specific to such peptides, and... Agent: Crowell & Moring LLP Intellectual Property Group

20070148645 - Nucleic acid sequencing methods, kits and reagents: The present invention relates to nucleic acid sequencing methods, kits and reagents, and more particularly to methods of sequencing nucleic acid which employ a nucleic acid processing enzyme and one or more nucleotide analogues that are capable of binding to the active site of the enzyme and to complementary bases... Agent: Dann, Dorfman, Herrell & Skillman

20070148674 - Optical fingerprinting of nucleic acid sequences: The present invention provides methods and apparatus for the optical fingerprinting of nucleic acid molecules. In certain embodiments, the invention provides methods for labeling nucleic acid molecules using-site-specific nucleic acid binding partners that bind to nucleic acids without cleaving the molecule. The nucleic acid binding partners can be labeled directly... Agent: Godfrey & Kahn, S.c.

20070148659 - Pcr-based prototype kit for detecting chlamydia trachomatis and nelsseria gonorrhoeae: The invention relates to a PCR based prototype kit for detecting Chlamydia trachomatis and Neisseria gonorrhoeae comprising: a transport medium for sample collection solution A and B, a reaction mixture having the primer for Chlamydia trachomatis and Neisseria gonorrhoeae, a gel loading dye, Agarose gel, gel running buffer and a... Agent: The Webb Law Firm, P.C.

20070148654 - Process for manufacturing biochip, probe solution, and biochip: The present invention provides a process for manufacturing a biochip having high density probe regions and being resistant to contamination caused by organic materials or the like. For achieving the object, the process for manufacturing a biochip of the present invention includes a step of adhering a probe solution to... Agent: Hamre, Schumann, Mueller & Larson P.C.

20070148662 - Prostate-specific membrane antigen: This invention provides an isolated mammalian nucleic acid molecule encoding a mammalian prostate-specific membrane antigen. This invention also provides prostate-specific membrane nucleic acid of at least 15 nucleotides capable of specifically hybridizing with a sequence of a nucleic acid molecule encoding a mammalian prostate-specific membrane antigen. This invention further provides... Agent: Cooper & Dunham LLP

20070148682 - Protein fragment complementation assays for the detection of biological or drug interactions: We describe a strategy for designing and implementing protein-fragment complementation assays (PCAs) to detect biomolecular interactions in vivo and in vitro. The design, implementation and broad applications of this strategy are illustrated with a large number of enzymes with particular detail provided for the example of murine dihydrofolate reductase (DHFR).... Agent: Isaac A. Angres

20070148686 - Protein present at the surface of hematopoietic stem cells of the lymphoid line and of nk cells, and uses thereof: The invention concerns a protein present at the surface of hematopoietic stem cells of the lymphoid cell line and mature NK cells, the corresponding isolated cDNA sequence and their uses as marker of said cells and for preparing antibodies directed against said protein. The invention also concerns the uses of... Agent: Alston & Bird LLP

20070148647 - Purification methods: The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group. The general concept being illustrated by the scheme:... Agent: Ge Healthcare, Inc.

20070148652 - Reagent for detecting an analyte: e

20070148675 - Structure designed for adsorption of dna intercalators: Provided is a structure designed for adsorption, which is suitable for removing dioxin and dioxin-like substances from leachate and ground water from polluted soils or garbage, washing effluent from garbage incinerators and so on that contain DNA intercalators, particularly, dioxin and dioxin-like substances. The structure designed for adsorption is a... Agent: Fitzpatrick Cella Harper & Scinto

20070148672 - System and method of facilitating animal propagation: The present invention provides a system and method of facilitating animal propagation. In one embodiment, the present invention utilizes data relating to the traits or characteristics of existing animals organized into various cow-bull pairs to predict the degree that those traits or characteristics will be exhibited by the offspring of... Agent: Daniel D. Chapman Jackson Walker, LLP

20070148643 - Treatment of huntington's disease with epa: Analysis of the huntington gene provides a method for identifying patients likely to respond to treatment of Huntington's disease with eicosapentaenoic acid, EPA.... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20070148660 - Treatment of maladaptive substance use with h-ras antagonists: The present invention provides a method of mitigating a symptom of maladaptive substance use in a subject by inhibiting H-ras. In addition, the invention provides a variety of prescreening and screening methods aimed at identifying agents that modulate a symptom of maladaptive substance use. Methods of the invention can involve... Agent: Quine Intellectual Property Law Group, P.C.

20070148691 - Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancers: This invention relates to compositions and uses of NRG4, and to variants thereof and to polynucleotides encoding NRG4, for therapeutic and diagnostic purposes, particularly related to colon and pancreatic cancer. This invention also relates to therapeutic agents based on or derived from the polynucleotides and proteins, NRG4 inhibitors, particularly antibodies... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20070148687 - Variable valve apparatus and methods: Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a... Agent: 3m Innovative Properties Company

20070148693 - Circular recombinant plasmid dna constructs and their protein products, methods of preparation and immobilisation of proteins on support: The invention relates to new circular recombinant plasmid DNA constructs and their protein products, to the use of said protein products in immobilisation, visualisation and quantification of enzymes and proteins on compatible support material. The invention also relates to a method of preparation and immobilisation of the protein on a... Agent: Ladas & Parry

20070148698 - Composite microarray slides: Improved composite microarray slides for use in micro-analytical diagnostic applications are disclosed. Specifically, composite microarray slides useful for carrying a microarray of biological polymers on the surface thereof including composite microarray slides having a porous membrane formed by a phase inversion process effectively attached by covalent bonding through chemical agents... Agent: 3m Innovative Properties Company

20070148696 - Highly-selective tandem chemical sensor and detection method using same: The invention relates to a chemical sensor intended for the detection of a type of molecule comprising a fluorescent material capable of forming a charge transfer complex with the type of molecule to be detected and means for measuring the variation in fluorescence of said material, characterized in that it... Agent: Lowe Hauptman Gilman & Berner, LLP

20070148701 - Immunological assay system and method: An immunological or immunohematological assay system is disclosed that includes a filter vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition system, and a robotic pipettor. The immunological assay system may also include a washer. Also disclosed is an immunological assay method that... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070148694 - Mass-based toxin assay and substrates therefor: An assay for a metalloprotease comprises (i) combining a test compound with a substrate, wherein the protease reacts with the substrate to form a product; and (ii) detecting presence of the metalloprotease by measuring the mass of the product.... Agent: Evan Law Group LLC

20070148702 - Measuring chip for surface plasmon resonance biosensor and method for producing the same: An objective of the present invention is to provide a measuring chip for a surface plasmon resonance sensor that can detect a small amount of target substances in high sensitivity. The present invention provides a measuring chip for a surface plasmon resonance sensor comprising a metal layer, one or more... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070148699 - Method for deriving a wellness related index for a food composition: A method for deriving a wellness related index for a composition for consumption by an animal by (a) evaluating an effect of the composition, relative to the effect of one or more comparative compositions, on each of a plurality of parameters indicative of the health or wellness of the animal;... Agent: Colgate-palmolive Company

20070148697 - Methods and system for high throughput screening of polymer materials for medical devices: The present invention provides a system for high-throughout analysis of a polymeric formulation for implantable and insertable medical devices comprising a plurality of dots arranged to form an array on a substrate having at least an x axis and y axis, each dot comprising a polymeric composition and wherein a... Agent: Mayer & Williams PC

20070148695 - Optically encoded particles, system and high-throughput screening: The invention concerns a particle having a code from a library of codes embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum.... Agent: Greer, Burns & Crain

20070148700 - Site-specific aminoglycoside derivatives for use in immunodiagnostic assays: A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups with a protecting reagent to provide protecting groups; removing the... Agent: Brinks Hofer Gilson & Lione

20070148704 - Anti-ccpand antinuclear antibodies in diagnosis of rheumatoid arthritis: The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in the differential diagnosis of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample both the concentration of anti-CCP and of... Agent: Roche Diagnostics Operations Inc.

20070148703 - Method of screening remedy for breast cancer: The present invention is a method for screening a remedy for breast cancer which does not require uptake into cells unlike aromatase inhibitors, estrogen sulfatase inhibitors, or estrogen competitive inhibitors such as tamoxifen and toremifene, and which shows excellent drug delivery property and extremely rare adverse effect. In the method,... Agent: Alston & Bird LLP

20070148706 - Pancreatic progenitor cells and methods for isolating the same: The invention provides animal models, where the ectopic expression of KGF, EGF, or both is under the control of a pancreas-specific promoter, e.g., the insulin promoter. The expression of KGF in the ins-KGF pancreatic islets of Langerhans results in enlarged islets, with substantial proliferation of duct cells within the islet... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070148705 - System and method for qualifying a logic cell library: A system and a method for qualifying a logic cell library storing process parameters and properties of a specific semiconductor FAB when the logic cell library is newly developed or modified is provided. The system for qualifying a logic cell library which qualifies a new library and a modified library,... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070148712 - Breast cancer and prostate cancer assessment: A method for detecting a biological marker in a sample, which comprises a complex mixture of molecules, from a patient comprising exposing a detection site having bound monoclonal antibodies specific for the biological marker to the sample, exposing the detection site to a detectably labeled reporter molecule, which is substantially... Agent: Barnes & Thornburg LLP

20070148714 - Clinical parameters for determining hematologic toxicity prior to radioimmunotherapy: New clinical parameters are reported which may serve as predictors of the hematological toxicity associated with therapeutic radiolabeled antibodies, particularly those antibodies which target lymphoma cells which have a tendency to localize to the bone marrow.... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20070148710 - Cpt resistant cell line: Disclosed are compositions relating to cells and cell lines that are resistant to a given chemotherapeutics as well as method for making and using the same.... Agent: Fish & Richardson P.C.

20070148711 - Identification of non-small cell lung carcinoma (nsclc) tumors expressing pdgfr-alpha: The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFRα) is expressed and is driving the disease, and provides methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFRα is... Agent: James Gregory Cullem, Esq. Intellectual Property Counsel

20070148713 - Protein markers for esophageal cancer: Computerized analysis of 2-D gels, both carrier ampholyte (CA) and immobilized pH gradient (IPG) based, of the proteins in tissue from esophageal tumors, reveals proteins which are different in tumor and control tissue.... Agent: Arent Fox PLLC

20070148716 - Device for monitoring a patient for a urinary tract infection: The invention provides for a urinary monitoring device to monitor for the presence or absence of markers indicative of a urinary tract infection (UTI). The invention also provides for methods of using such a device.... Agent: Fish & Richardson P.C.

20070148715 - Method for detecting transient ligand interactions: The invention relates to methods and kits for separating, and optionally analyzing, substoichiometrically interacting ligands from a high abundance ligand of interest in an affinity matrix system. The methods comprising immobilizing a complex of a first and second ligand to an affinity matrix, wherein the second ligand is bound to... Agent: Bereskin And Parr

20070148717 - Sensitive immunochromatographic assay: Methods for quantitatively measuring the amount of an analyte of interest in a fluid sample, and kits useful in the methods, are disclosed. The methods involve providing a solid phase apparatus comprising a membrane having an application point, a sample capture zone, and a control capture zone, where the sample... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070148709 - Molecular tag reader: Near-infrared molecular assays can be used to detect small quantities of a molecule of interest in vivo or in vitro using laser dyes. A hand-held portable device is provided which can rapidly read small quantities of selected molecular tags in tissues of fish or other animals in the field. The... Agent: U.s. Army Space And Missile Defense Command

20070148708 - Protease inhibitor conjugates and antibodies useful in immunoassay: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavor. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal... Agent: Marilyn L. Amick Roche Diagnostics Corporation

20070148707 - Systems and methods for detection of analytes in biological fluids: The invention provides a heterogeneous immunoassay for detection of antibodies and antigens based on specific antigen-antibody immune complex formation with multiple antigen-bearing conjugate components. The invention further provides means for optimizing the assay format for the detection of both low and high-affinity antibodies, and provides means for quantitative detection of... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070148718 - Fas binding antibodies: The disclosed invention relates to monoclonal antibodies (MAbs) which recognize human fatty acid synthase (hFAS) and are distinct from previously known anti-hFAS antibodies. Compositions, devices and kits comprising the MAbs are provided along with methods of using the MAbs in a variety of applications.... Agent: Townsend And Townsend And Crew, LLP

20070148721 - Compositions, methods, systems, and kits for affinity purification: The invention provides a method of separating proteins and peptides of a sample comprising contacting the sample with a Pd coordination compound. The Pd coordination compound binds to sulfur and/or nitrogen groups and thus is useful for purifying biomolecules comprising cysteine, methionine, histidine amino acids or derivatized amino acids/residues comprising... Agent: Agilent Technologies Inc.

20070148722 - Method for determining the concentration of thrombin inhibitors: The invention relates to a method for determining the concentration of thrombin inhibitors in a non-turbid body liquid or a non-turbid extract from a body liquid. It comprises the following steps. The body liquid is taken from a living body, and the body liquid is subjected to a separation from... Agent: Millen, White, Zelano & Branigan, P.C.

20070148720 - Method of identifying protein with the use of mass spectometry: The present invention provides an approach for identifying with high accuracy, a known protein or a variant of the known protein derived from the same genomic gene as in a target protein to be analyzed, based on a mass spectrometric result of a plurality of peptide fragments obtained from site-specific... Agent: Dickstein Shapiro LLP

20070148724 - Inhibition assay method and device for detection of antibiotics: An aspect of the disclosure is a method and device for the detection of antibiotics in a sample. Embodiments include a microbial culture with growth indicators and sensitivity adjustment reagents. Adjustment reagents include a variety of antibiotic binders that can be added to microbial culture to reduce sensitivity to certain... Agent: Charm Sciences Inc Richard J Long

20070148725 - Soil microorganism-housing biosensors and their uses: Microorganism sensors used in environment assessment technologies and the like, instead of being used to detect environmental components and determine their concentrations, were used as tools to evaluate the ability of target soil microorganisms to adapt to various field soil environments, and comparative studies were performed. As a result, the... Agent: Nixon Peabody LLP - Patent Group

20070148726 - Cell culture and mixing vessel: A mixing vessel (10) for containing a liquid, comprises a chamber having a lower chamber portion and an upper chamber portion wider than the lower portion, gas inlet means (14) for supplying gas to the lower portion and means for redirecting rising gas (24), such that, in use, rising gas... Agent: Morgan Lewis & Bockius LLP

20070148727 - Novel carotenoid hydroxylase gene, method for preparing hydroxylated carotenoid, and novel geranylgeranyl pyrophosphate synthase: The present invention provides a Brevundimonas sp. strain SD212-derived peptide having β-ionone ring-2-hydroxylase activity and a gene encoding the same, to thereby make it possible to produce rare carotenoids in which a hydroxyl group is introduced at the position 2 (2′) carbon in their β-ionone ring in large quantities. The... Agent: Birch Stewart Kolasch & Birch

20070148728 - Synthesis of oligosaccharides, glycolipds, and glycoproteins using bacterial glycosyltransferases: This invention provides nucleic acid and amino acid sequences of fucosyltransferases from Helicobactor pylori. The invention also provides methods to use the fucosyltransferases to synthesize oligosaccharides, glycoproteins, and glycolipids.... Agent: Townsend And Townsend And Crew, LLP

20070148736 - Apparatus and method for separating viral particles from cells: A method for analyzing a sample to detect cells infected by Human Papilloma Virus (HPV) is provided. The method includes passing a medium containing the sample across a filter. The filter has a pore size that is greater than a dimension of a HPV particle, but smaller than a dimension... Agent: Cytyc Corporation

20070148731 - Efficient protein expression system: Nucleic acid expression control sequence cassettes and vectors containing the same are provided for use in making abundant quantities of recombinant polypeptides of interest. The modified transcriptional control sequences, which include a T5 promoter sequence, are highly stable and can be used in a variety of vectors, such as plasmids.... Agent: Seed Intellectual Property Law Group PLLC

20070148734 - Hyaluronic acid mediated adenoviral transduction: The present invention provides methods of treatment of adenoviral mediated disease, improved methods for transducing cells with adenoviral and related vectors, and improved methods of gene therapy utilizing such methods.... Agent: Fulbright & Jaworski, L.L.P.

20070148737 - Materials and methods for the purification of polyelectrolytes, particularly nucleic acids: The present invention provides novel rapidly growing microorganisms and methods for their use in cloning or subcloning nucleic acid molecules. The rapid growing microorganisms of the present invention form colonies more rapidly than microorganisms typically used in molecular biology and thus provide a significant improvement in in vitro cloning methods... Agent: Invitrogen Corporation C/o Intellevate

20070148729 - Methods for increasing neisseria protein expression and compositions thereof: The present invention broadly relates to polynucleotide sequences encoding porin polypeptides of Neisseria. More particularly, the invention relates to newly identified nucleic acid sequence mutations in polynucleotides encoding PorA polypeptides of Neisseria meningitidis, wherein these sequence mutations result in increased expression levels of PorA polypeptides.... Agent: Hunton & Williams LLP Intellectual Property Department

20070148735 - Novel chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070148732 - Novel enzymes: The present invention relates to novel cellulase enzymes, especially novel endoglucanases including endoglucanase fusion proteins, preparations and compositions containing these endoglucanase enzymes and fusion proteins, expression vectors, host cells and methods for their preparation and uses of the cellulases, preparations and compositions in the textile, detergent and pulp and paper... Agent: Banner & Witcoff, Ltd.

20070148730 - Superactive cellulase formulation using cellobiohydrolase-1 from penicillium funiculosum: Purified cellobiohydrolase I (glycosyl hydrolase family 7 (Cel7A) enzymes from Penicillium funiculosum demonstrate a high level of specific performance in comparison to other Cel7 family member enzymes when formulated with purified EIcd endoglucanase from A. cellulolyticus and tested on pretreated corn stover. This result is true of the purified native... Agent: Paul J White National Renewable Energy Laboratory

20070148738 - Transcriptional regulator: Genes each encoding a novel transcriptional regulator having a bromodomain have been successfully isolated from a human testis cDNA library using primers prepared based on an EST sequence found using the bromodomain sequence of the transcriptional regulator. These genes are structurally analogous to each other.... Agent: Fish & Richardson PC

20070148733 - Yeast expression vectors for production of itf: The invention features ITF expression vectors and methods of producing ITF.... Agent: Clark & Elbing LLP

20070148739 - Fusion proteins of interferon alpha muteins with improved properties: The invention concerns human interferon alpha and in particular modified forms of interferon alpha 2 with improved properties. The improved proteins contain amino acid substitutions at specific positions that confer increased relative activity in biological assays. The invention provides also modified interferon alpha with improved biological activity concomitant with reduced... Agent: Olson & Hierl, Ltd.

20070148740 - Chondroitinase abc i and methods of degrading therewith: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans... Agent: Wolf Greenfield & Sacks, P.C.

20070148741 - Mashing process: The present invention relates to a mashing and filtration step in a brewing process and to a composition useful in the mashing and filtration step of a brewing process. The mash is prepared in the presence of enzyme activities comprising a xylanase of GH family 10.... Agent: Novozymes North America, Inc.

20070148742 - Process for the production of amino acids: The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070148743 - Microbiological method for producing amides: The present invention provides for microorganisms capable of tolerating acetonitrile concentrations of at least 3 M, enzyme extracts obtainable from these microorganisms, a nitrile hydratase obtainable from these microorganisms, a method for preparing amides using these microorganisms, the enzyme extracts or the nitrile hydratase obtainable therefrom, and a method for... Agent: Nixon & Vanderhye, PC

20070148744 - Bafilomycin-like metabolite from a novel micromonospora species: The invention provides a compound of formula (I) and pharmaceutically acceptable salts thereof. Processes for the isolating of this bafilomycin metabolite from a novel Micromonospora species, pharmaceutical compositions containing this metabolite and methods of treatment using said metabolite are also described.... Agent: Philip S. Johnson Johnson & Johnson

20070148747 - Genes involved in polyketide synthase pathways and uses thereof: The subject invention relates to isolated nucleic acid sequences or genes involved in polyketide synthase (PKS) biosynthetic pathways. In particular, such pathways are involved in the production of polyunsaturated fatty acids (PUFAs) such as, for example, Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA). Specifically, the invention relates to isolating nucleic... Agent: Robert Deberardine Abbott Laboratories

20070148746 - Process for the enzymatic synthesis of triglycerides: The invention relates to a process for the enzymatic synthesis of esters of polyunsaturated, short-chain or sensitive fatty acids with a high triglyceride content, which is made up of an enzymatic synthesis of the mixture of triglycerides and partial glycerides starting from free fatty acid, methyl or ethyl esters and... Agent: Cognis Corporation Patent Department

20070148745 - Process for the production of diacylglycerol: The present invention provides a process for producing a diacylglycerol, which comprises, reacting triacylglycerol with water and an enzyme to obtain a mixture comprising of diacylglycerol, monoacylglycerol and free fatty acid; removing water content in the mixture by way of dehydration; and separating monoacylglycerol, free fatty acid and residual triacylglycerol... Agent: Nath & Associates

20070148748 - Fermentation process using specific oxygen uptake rates as a process control: Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using... Agent: Gary C. Cohn, PLLC

20070148749 - Process for producting 1,3-propanediol and or/3-hydroxypropionic acid: This invention is intended to improve the efficiency of producing 1,3-propanediol from glycerol and to provide an industrially effective process for producing the same. Such process involves the use of a transformant comprising the gene encoding the large subunit of glycerol dehydratase and/or diol dehydratase, the gene encoding the medium... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070148750 - Method for producing monosaccharides from biomass and monosaccharide production device: This monosaccharide production method is a method for producing monosaccharides from biomass having a first step 3 in which a raw material biomass is pretreated in 65 to 85 (w/w) % sulfuric acid at a temperature of 30 to 70° C., and a second step 4 in which the first... Agent: Darby & Darby P.C.

20070148751 - Method of processing lignocellulosic feedstock for enhanced xylose and ethanol production: The present invention provides a method of producing xylose from lignocellulosic feedstock. The method comprises disrupting lignocellulosic feedstock; leaching the lignocellulosic feedstock by contacting the feedstock with at least one aqueous solution for a period greater than about 2 minutes to produce a leached feedstock and a leachate; removing the... Agent: Brinks Hofer Gilson & Lione

20070148752 - Sulfated fucogalactan digesting enzyme gene: A gene encoding a polypeptide having an activity of digesting sulfated fucogalactan which is useful in sugar chain engineering reagents, analyzing the structures of sulfated fucose-containing polysaccharides and preparing degraded products of the polysaccharides; a genetic engineering process for producing the polypeptide; and the polypeptide obtained by the process.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070148753 - Preparation of cells for production of biologicals: The present invention relates to a method for the preparation of cells for use in the production of biologicals, by culturing cells up till a desired cell volume of a preproduction batch, where after in a repeated discontinous process: a) part of the cells of the preproduction batch is used... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070148754 - Methods and compositions for improving plant growth: The present invention has surprisingly discovered that certain spore-forming microorganisms, present in soil, plants and other forms of organic matter, survive excessive heat of a fire within soil or carbonized wood. It has been determined that such microorganisms stimulate plant growth, enhance the nutritional value of plant products, and incorporate... Agent: Scully Scott Murphy & Presser, PC

20070148755 - Biocontrol formulation containing streptomyces spp., method for preparing the formulation and relevant use: The present invention is a method for preparing a biocontrol formulation by the following steps. A Streptomyces bacterium is selected simultaneously with superior sporulation ability, chitinase activity and antagonistic effectiveness against plant fungal pathogens by culturing with fungal pathogens, wherein the selected Streptomyces bacterium is cultured on a chitin-limited plate... Agent: Nikolai & Mersereau, P.A.

20070148756 - Tissue dissociation device: A tissue dissociation device (10) includes a container (12) having a sterile interior for holding the tissue to be dissociated and a liquid medium. The device (10) also includes a dissociation element (54), inside the container (12), for engaging the tissue to cause dissociation of the tissue. The device (10)... Agent: Battelle Memorial Institute

20070148758 - Electrofusion microelectrode: The present invention is directed to an electrofusion microelectrode used in the alignment, manipulation, fusion, or electroporation of cells. This device is particularly useful for transplantation of cells and cellular components.... Agent: Nixon Peabody LLP - Patent Group

20070148757 - Electrofusion microelectrode and methods of using it to manipulate cells and/or cellular components: The present invention relates to an electrofusion microelectrode made of a tube having a first proximal end and a second distal end. The tube has an electrically conductive coating on its exterior surface that extends continually from the first proximal end of the tube toward the second distal end of... Agent: Nixon Peabody LLP - Patent Group

20070148759 - Biological sample discrimination device, biological sample discriminating method, and biological sample discriminating plate: There is provided a plate (10) on which a channel pattern (110) is formed, which channel pattern includes a first channel (116) into which a buffer agent is injected, and a second channel (117) having, in a portion thereof, a quantification part (117a) that has a portion common to the... Agent: Wenderoth, Lind & Ponack L.L.P.

20070148761 - Instrument for monitoring polymerase chain reaction of dna: An optical instrument monitors PCR replication of DNA in a reaction apparatus having vials of reaction ingredients. A beam splitter passes an excitation beam to the vials. An emission beam from the reaction ingredients can be passed by the beam splitter to a detector from which a processor can compute... Agent: Kilyk & Bowersox, P.l.l.c.

20070148760 - Obtaining analyte information: Light, such as from an analyte-wavelength converter or other optical sensor, is propagated to a detector or transmission structure with an entry surface and with output positions such as in an exit surface. For example, the position of light output by such a detector can be used to detect presence... Agent: Leading Edge Law Group, PLC/xerox-parc

20070148763 - Quantitative cell dispensing apparatus using liquid drop manipulation: Provided is a quantitative cell dispensing apparatus using liquid droplet manipulation, for quantitatively dispensing cells from hydrophilic suspension containing a plurality of cells. The quantitative cell dispensing apparatus includes hydrophilic suspension, a liquid droplet manipulation unit, a dispensing unit, a sensing unit, and a control unit. The hydrophilic suspension includes... Agent: Cantor Colburn, LLP

20070148762 - Cell culture patterning substrate: A cell culture patterning substrate on which cells can be arranged regularly with high efficiency over a large area on a base material so as to attain formation of a tissue, etc. The cell culture patterning substrate includes: a base material; and a cell culture region which is formed on... Agent: Ladas & Parry LLP

20070148764 - Device for cell culture: A device for cell culture capable of automatically performing operations for cell culture over several days to several months while minimizing the risk of contamination. A new medicine can be supplied to an incubator means by using a medicine supply means or unnecessary wastewater can be discharged from the incubator... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070148765 - Preservative-containing virus formulations: The preservation of live viral vaccines is disclosed. These liquid formulations comprise a live virus and a preservative, namely chlorobutanol. The preserved, live virus formulations of the present invention are (1) suitable for a vaccine or gene therapy product with a multi-dose image; (2) compatible with parenteral administration; and (3)... Agent: Merck And Co., Inc

20070148770 - Macroporous chitosan beads and preparation method thereof: The present invention relates to macroporous chitosan beads having 5-200 μm in size of relatively large and uniform pores that are distributed from surface to core region. The macroporous chitosan beads of the present invention make cell culturing efficient. Cells can attach to them efficiently due to their large surface... Agent: Jhk Law

20070148766 - Method and system for preparing stem cells from fat tissue: The present invention provides a method for preparing homogeneous stem cells and/or precursor cells in a large amount, in a simple and efficient manner, from human (in particular, the subject per se). The present invention further provides a method for preparing tissue implant or graft in a large amount by... Agent: Seed Intellectual Property Law Group PLLC

20070148767 - Method of forming multicellular spheroids from the cultured cells: Provided herein are methods for producing multicellular spheroids or embryoid bodies suitable for providing cells in large scale for various medical applications. In one embodiment, a method of forming embryoid bodies is provided, which comprises culturing undifferentiated HES cells in a culture vessel pre-coated with cellulose and/or its derivatives. In... Agent: Rabin & Berdo, P.C. Suite 500

20070148769 - Methods and devices for the long-term culture of hematopoietic progenitor cells: The invention pertains to methods and devices for the long term, in vitroculture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors, improved methods for the introduction of foreign genetic material into cells of hematopoietic origin, and to apparatus for performing these methods. The hematopoietic progenitor... Agent: Wolf Greenfield & Sacks, P.C.

20070148771 - Reconstructed epidermis/skin equivalent comprising a ceramide 7 and/or 5.5 and lipid lamellar vesicular compositions comprising ceramide 7 and/or 5.5 compounds: A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the barrier function of dry skin and of reconstructed skin or skin equivalents, is prepared by introducing the at least one ceramide 7... Agent: Buchanan, Ingersoll & Rooney PC

20070148768 - Surface modification of polysaccharide, the modified polysaccharide, and method of culturing and recovery cells using the same: A surface modification method of polysaccharide, the modified polysaccharide, and a method of culturing and recovery cells using the same are provided. The surface modification method of polysaccharide comprises (a) immersing a polysaccharide material in an acid, (b) immersing the polysaccharide material in an acidic solution containing a protein, and... Agent: Birch Stewart Kolasch & Birch

20070148772 - Leukocyte cell banks: The invention relates to a novel form of leukapheresis (isolated leukapheresis), to processes and apparatus for carrying out isolated leukapheresis, to leukocyte cell banks created thereby and to various forms of therapy based thereon.... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20070148773 - Sequence specific dna recombination in eukaryotic cells: The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA comprising a nucleotide sequence containing at least one further recombination sequence... Agent: Fulbright & Jaworski L.L.P.

20070148774 - Methods for producing members of specific binding pairs: A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding... Agent: Howrey LLP

20070148775 - Method for cloning and expressing target gene by homologous recombination: A method for cloning and expressing a target gene by homologous recombination, and more particularly a method for cloning and expressing a target gene by homologous recombination, wherein a host cell transformed with a recombinant vector and a plasmid containing a recombinase system is introduced with a linear DNA fragment... Agent: Intellectual Property / Technology Law

20070148776 - Method capable of increasing competency of bacterial cell transformation: The invention concerns bacterial strains capable of enhanced transformation efficiencies that are produced by the introduction of the F′ genetic material. The invention also concerns processes for producing transformable competent bacteria with enhanced transformation efficiencies.... Agent: Invitrogen Corporation C/o Intellevate

20070141562 - Apparatus and methods for high yield microbial surface sampling: This invention discloses an apparatus and methods for high yield microbial surface sampling. The microbial sampling techniques in which a sample is obtained from an environmental or biological surface using a microfiber material in the form of microfiber devices, wipes, or swabs.... Agent: Thomas H. Grove

20070141559 - Methods for detecting and typing herpes simplex virus: Detailed herein are methods of detecting herpes simplex virus and differentiating between types 1 and 2 by simultaneous detection of type-specific gene sequences. In particular aspects, individuals infected with HSV-1 can be distinguished from those infected with HSV-2 by amplification and detection of the HSV-1 glycoprotein B gene or the... Agent: Foley & Lardner LLP

20070141584 - Methods for assessment of native chromatin on microarrays: A method for determining chromatin accessibility of nucleic acids in a cell by expressing an effective amount of a nuclease in a cell to digest chromatin at chromatin accessible sites to form chromatin fragments; isolating chromatin fragments from the cell; and hybridizing the chromatin fragments on a microarray to determine... Agent: Agilent Technologies Inc.

20070141583 - Methods of rapid chromatin immunoprecipitation: This invention is related to a method for rapidly identifying regions of the genome to which specific proteins bind, or identifying specific proteins bound to a region of the genome in vivo.... Agent: Jessica M. Li

20070141678 - Processes for purifying oligosaccharides: Processes for purifying oligosaccharides including contacting a basic oligosaccharide solution with a basic boronate resin to bind monosaccharides to the basic boronate resin and obtain a purified oligosaccharide solution. The basic boronate resin can bind about 50% of the monosaccharides and about 10% of oligosaccharides in the basic oligosaccharide solution,... Agent: The Procter & Gamble Company Intellectual Property Division - West Bldg.

20070141548 - Organ transplant solutions and method for transplanting organs: A preservation solution for organs waiting to be transplanted is disclosed; the method of using the solution in a transplantation procedure is also disclosed. The preservation solutions comprise a balanced isotonic aqueous solution comprising sodium, potassium, calcium, magnesium and bicarbonate ions in a physiologically acceptable amount, together with an effective... Agent: Frost Brown Todd, LLC

20070141552 - Automatable artificial immune system (ais): The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates... Agent: Merchant & Gould PC

20070141551 - Compositions and methods for lipoprotein uptake assays: Provided herein are compositions and methods for lipoprotein uptake assay. These compositions and methods may be used for the lipoprotein uptake assays, including high-throughput assays. The disclosed compositions and method may further be used to characterize the activity agents that inhibit or stimulate lipoprotein uptake.... Agent: General Electric Company Global Research

20070141555 - Current damper for the study of cells: A device for the study of cells including a vessel with a current damper including a damping component substantially disposed within the vessel is disclosed. The damping component reduces or eliminates currents formed by the addition of materials such as liquids to the vessel to prevent the movement of cells... Agent: Martin D. Moynihan Prtsi, Inc.

20070141550 - Immobilized-enzyme microreactor devices for characterization of biomolecular analytes and associated methods: A method that comprises providing a polymerized sol-gel material (PSG) and linking an enzyme to a surface of the PSG via covalent linkage is provided. The surface of the PSG is derivatized with a linker that comprises a functional group for linking itself to the surface of the PSG and... Agent: Parsons Hsue & De Runtz LLP

20070141553 - Method and biochip for studying a chemical sample: A method for studying a biological sample in a biochip (“lab-on-a-chip”) is disclosed. In at least one embodiment of the method, a biological sample is introduced into the biochip, the sample is subjected to at least one preparation step and, at the end of a measurement cycle, the concentration of... Agent: Harness, Dickey & Pierce, P.L.C

20070141556 - Method for immobilizing a biomolecule on a solid substrate at a high density by using the substrate having an active carboxyl group on a surface thereof and microarray produced using the method: Provided is a method for immobilizing a biomolecule on a solid substrate. The method includes coating the solid substrate with silane anhydride to introduce an anhydride functional group onto a surface of the solid substrate; obtaining a carboxyl group from the anhydride functional group by hydrolysis; reacting the carboxyl group... Agent: Cantor Colburn, LLP

20070141554 - Stable cell lines expressing herg: A stable eukaryotic cell line that expresses hERG and exhibits a stable current under electrophysiological test conditions is provided.... Agent: Roche Palo Alto LLC Patent Law Dept. M/s A2-250

20070141549 - Test system for the evaluation of a coating to biofouling and fluid shear forces: Described is a test system for the evaluation of a coating to biofouling and fluid shear forces in natural seawater, comprising: a support structure for holding test panels, a first array of separate, spaced apart test panels being arranged on the support structure (a) in two or more coaxial circles... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20070141563 - Control for nucleic acid testing: The present invention is related to a method for detecting a target biomolecule in test sample by adding an internal control biomolecule to the test sample; to a negative control sample, to a positive control sample and to a reagent control sample or adding an internal control biomolecule to the... Agent: Roche Molecular Systems Inc Patent Law Department

20070141557 - Method and device for optimizing a nucleotide sequence for the purpose of expression of a protein: The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is... Agent: Pillsbury Winthrop Shaw Pittman LLP

20070141564 - Method for the rapid diagnosis of targets in human body fluids: More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070141561 - Microfluidic device and method for concentration or purification of sample containing cells or viruses: A microfluidic device for concentrating or purifying a sample containing cells or viruses including a sample circulating vessel having a constant capacity; a pump connected to the sample circulating vessel and a trapping unit located in the sample circulating vessel. A method of concentration or purifying a sample containing cells... Agent: Cantor Colburn, LLP

20070141565 - Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome: The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy. According to the invention, polymerase chain reaction assays may be used to predict immunological decline and to identify, at an early stage, patients whose... Agent: Howrey LLP

20070141560 - Probes and methods for hepatitis c virus typing using multidimensional proble analysis: This invention provides compositions and methods for HCV typing, e.g., genotyping and/or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at least five HCV types (for example, selected from types 1, 2, 3, 4, 5 or 6), or to... Agent: Quine Intellectual Property Law Group, P.C.

20070141558 - Quantitative assay for detection of newly synthesized rna in a cell-free system and indentification of rna synthesis inhibitors: Methods for detecting populations of newly synthesized and newly initiated RNAs in a cell-free system are described. Suitable templates for the populations of newly synthesized and newly initiated RNAs are viral replicon RNAs, particularly HCV viral replicon RNA. The newly synthesized and newly initiated RNAs may be formed in the... Agent: Cantor Colburn, LLP

20070141586 - Abasic site endonuclease assay: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.... Agent: Townsend And Townsend And Crew, LLP

20070141585 - Altered gene expression profiles in stable versus acute childhood asthma: Differences in gene expression in control and asthma patients to profile, differentiate, evaluate, etc. patients with exacerbated asthma and stable asthma.... Agent: Wood, Herron & Evans, LLP

20070141593 - Apparatus, system, and method using immiscible-fluid-discrete-volumes: Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic... Agent: Leonard D. Bowersox

20070141570 - Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods: Polymorphic A-kinase anchor proteins (AKAPs) and nucleic acids encoding the proteins are provided herein. Methods of detecting polymorphic AKAPs and nucleic acids encoding the AKAPs, and kits for use in the detection methods are also provided. Further provided herein are methods of identifying subjects having or at risk of developing... Agent: Grant Anderson LLP C/o Portfolioip

20070141576 - Biological chip and use thereof: A biological chip includes probes immobilized on a circumferential side wall of a discoidal or cylindrical substrate. The probes contain a nucleic acid, a peptide, a saccharide, a lipid, a chemical substance, or a fragment thereof. The disc or cylinder is rotated so as to attain rapid intake of massive... Agent: Young & Thompson

20070141597 - Biomimetic biodetector of toxins, viruses, bacteria, and biological factors: A method for detecting a target agent in an environment is disclosed. The method includes preparing a biomimetic ligand, the ligand providing a site at which the target agent will bind. The method also includes covalently bonding a colorimetric indicator with the biomimetic ligand on a non active site of... Agent: Fellers Snider Blankenship Bailey & Tippens

20070141622 - Buffers for electrophoresis and use thereof: Various embodiments provide, for example, buffer compositions and/or sieving formulations useful in connection with electrophoresis instruments, such as capillary electrophoresis (CE) devices. In various embodiments, a buffer composition can include Bis-Tris, TAPS and/or TAPSO, and, optionally, a chelating agent, such as EDTA. Methods of separating samples containing bio-molecules, such as... Agent: Knobbe Martens Olson & Bear LLP

20070141608 - Chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070141573 - Complement inhibitors: The invention relates to complement inhibitors that inhibit both the classical and alternative complement pathways. In particular, the invention relates to complement inhibitors derived from the salivary glands of haematophagous arthropods that inhibit both the classical and alternative complement pathways. The invention also relates to the use of such complement... Agent: Klauber & Jackson

20070141623 - Correction method for the distribution of quantity of light and biochip-reader: The present invention is characterized by the following points: In a biochip reader used for reading a measurement sample image by light beam irradiation, a correction method for the distribution of quantity of light which is devised to remove the influence of shading for the whole image and such a... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20070141571 - Diagnostics and therapeutics for diseases associated with endothelial differentiation, sphingolipid g-protein-coupled receptor 6(edg6): The invention provides a human EDG6 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders, thrombocytopenia and myeloma. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal... Agent: Banner & Witcoff, Ltd.

20070141591 - Dna binding protein-polymerase chimeras: The invention relates to compositions and methods directed to chimeric DNA polymerases, which comprise a mutated DNA binding polypeptide domain and a mutated or wild-type DNA polymerase polypeptide domain.... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070141619 - Drug resistance-associated gene and use thereof: The present invention relates to a protein which excretes cancer chemotherapeutic drugs from a cell and which confers drug-resistance on the cell, a DNA encoding the protein, a method for detecting a cell type resistant to cancer chemotherapeutic drugs, a method for screening an inhibitor to overcome the resistance to... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070141617 - Enveloped virus vaccine and method for production: The present invention provides methods of production of a purified enveloped virus antigen. In particular, it provides purified Ross River Virus (RRV) antigens, and vaccines comprising purified, inactivated Ross River Virus (RRV) antigen.... Agent: Baxter Healthcare Corporation

20070141587 - Gene expression profiling in biopsied tumor tissues: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and