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Chemistry: molecular biology and microbiology June archive of inventions by patent app class 06/07

Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application.
  
06/28/2007 > patent applications in patent subcategories. archive of inventions by patent app class

20070148636 - Method, compositions and kits for preparation of nucleic acids: Methods, compositions and kits are provided for labeling, copying and/or amplifying nucleic acids. The methods, compositions and kit can be used for a variety of applications, for example, genome-wide scanning applications such as CGH or location analysis.... Agent: Agilent Technologies Inc.

20070148670 - Methods for detecting conformational changes in bioentities: Described herein are methods for detecting conformational changes in bioentities.... Agent: Corning Incorporated

20070148658 - Systems and methods for biopolymeric probe design using graphical representation of a biopolymeric sequence: Systems and methods for using the same to obtairi one or more probe sequences in response to an input graphical representation of a biopolymeric sequence are provided. Also provided are computer program products for executing the subject methods.... Agent: Agilent Technologies Inc.

20070148719 - Bioassay element and its producing method: The present invention relates to a bioassay element and its producing method. The bioassay element includes a carrier, a testing material, and a coating film, in which the testing material is dispersed in the coating film which covers on the surface of the carrier and comprises a casein and calcium... Agent: Birch Stewart Kolasch & Birch

20070148723 - Method and apparatus for detecting presence of toxic material within sample: Provided is a method for detecting the degree of toxicity of toxic materials within a sample. The method includes contacting sub-mitochondrial particles having competent mitochondrial enzyme formed from the inner membranes of mitochondria, an electron donor which transmits electrons to the electron transfer system of the sub-mitochondrial particles, and a... Agent: Cantor Colburn, LLP

20070148628 - Organ preservation and/or perfusion: The present invention relates to a solution for preservation, perfusion, and/or reperfusion of an organ, especially the heart, for transplantation. The solution contains peptide inhibitor(s) of protein kinase C ε (PKC ε). Methods for using the inventive solution are also disclosed, including methods for preserving an organ for transplantation, for... Agent: Blank Rome LLP

20070148629 - Composition for the preservation of viruses: The present invention relates to a composition for the preservation of a virus, the composition including a virus, a lipid and a cryoprotectant.... Agent: Birch Stewart Kolasch & Birch

20070148630 - Removal of adenine during a pathogen reduction process in whole blood or red blood cells by dilution: The methods of this invention involve preventing the formation of a complex between adenine and riboflavin by reducing the amount of adenine in a solution containing blood or blood components to be pathogen reduced.... Agent: Gambro, Inc Patent Department

20070148634 - Cells having a spectral signature and methods of preparations and use thereof: Methods, compositions and articles of manufacture for encoding a cell with semiconductor nanocrystals and/or other fluorophors are provided. The encoded cells can be subjected to functional assays in mixed populations, and an assay result can be determined and associated with individual cells by virtue of their code. The methods are... Agent: Invitrogen Corporation C/o Intellevate

20070148633 - Dielectric properties models and methods of using same: Disclosed herein are dielectric properties models that are designed to enable simulated use testing by medical device companies, medical device designers, individual inventors, or any other entity interested in the performance of medical devices. These models are unique in possessing a level of correlation to dielectric properties of human or... Agent: Beusse Wolter Sanks Mora & Maire

20070148632 - Levenberg-marquardt outlier spike removal method: Systems and methods for identifying and removing spikes in data sets representing PCR growth curves or other sigmoid type curves or growth curves. A double sigmoid function with parameters determined using a Levenberg-Marquardt regression algorithm is used to find an approximation to the curve, and a statistical test such as... Agent: Townsend And Townsend And Crew, LLP

20070148631 - Methods and apparatus for screening for chromosomal abmormalities: This invention generally relates to methods, apparatus, and computer program code for antenatal screening for chromosomal abnormalities, in particular Down's Syndrome. A method of determining a likelihood of a fetus carried by a pregnant mother having a chromosomal abnormality, a first biological, parameter being suitable for screening said fetus for... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20070148635 - Immobilized carbohydrate biosensor: A biosensor in which a carbohydrate or a derivative of a carbohydrate is used to generate a detectable signal by way of the specific binding to a protein, a virus or a cell.... Agent: Smith, Gambrell & Russell

20070148638 - Method for detecting low concentrations of a target bacterium that uses phages to infect target bacterial cells: The invention is directed to a method for detecting low concentrations of bacteria in liquid solution that may or may not be complex liquid solutions. In one embodiment, immunomagnetic separation (IMS) is used to separate target bacterium that may be in a liquid mixture from other constituents in the mixture.... Agent: Christopher J. Kulish, Esq

20070148639 - Methods and devices for nucleic acid amplification on a surface: Described are methods and devices for immobilizing primers on the surface of a microarray with polymer linkers. Nucleic acid amplification and total analysis without the necessity of polymerase chain reaction may be accomplished with the disclosed methods and devices.... Agent: Trask Britt

20070148640 - Methods and kits for decreasing interferences in plasma or serum containing assay samples of specific binding assays: Methods and kits are provided for decreasing interferences and inaccuracies due to nonoptimal sample handling of blood samples in plasma or serum containing assay samples of specific binding assays by addition of a large polycation to the assay sample during the specific binding assay.... Agent: Robert Deberardine Abbott Laboratories

20070148637 - Species-specific probes for identification of target virus and identification method using said probes: The inventions provides a method for identifying a target virus in an infected subject comprising the steps of designing a pair of degenerate primers corresponding to highly conserved regions of the target virus; designing a pair of species-specific primers according to highly variable sequences within the conserved regions of the... Agent: Akin Gump Strauss Hauer & Feld L.L.P.

20070148690 - Analysis of gene expression profiles using sequential hybridization: This invention relates generally to analysis of gene expression profiles. In particular, the present invention provides a method for a method for analyzing gene expression profiles of a cell, which method comprises: a) providing for isolated mRNA or cDNA target sequences from a cell; b) sequentially hybridizing said isolated mRNA... Agent: Morrison & Foerster LLP

20070148683 - Annealing control primer and its uses: The present invention relates to an annealing control primer for improving annealing specificity in nucleic acid amplification and its applications to all fields of nucleic acid amplification-involved technology. The present primer comprises (a) a 3′-end portion having a hybridizing nucleotide sequence substantially complementary to a site on a template nucleic... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070148685 - Capture, concentration and quantitation of abnormal prion protein from biological fluids using depth filtration: Methods for producing biological solutions such as immunoglobulins and in particular anti-D immunoglobulin substantially free of abnormal prion protein resulting therefrom. Specifically provided are methods for aggregation of prions and depth filtration of the biological solution to capture and remove abnormal and if desired, normal prion protein. The prion protein... Agent: Philip S. Johnson Johnson & Johnson

20070148649 - Cartridge for nucleic acid separation and purification and method for producing the same: A cartridge for nucleic acid separation and purification and a method for producing the cartridge are provided which does not require a special facility for adhering containers and can produce a number of cartridges at the same time. Also is provided a cartridge for nucleic acid separation and purification in... Agent: Sughrue Mion, PLLC

20070148689 - Compositions and methods for the prevention, treatment and detection of tuberculosis and other diseases: Methods and compositions are provided for the prevention and treatment of infectious diseases such as syphilis, tuberculosis, pneumonia, other bacterial infections, AIDS, and other viral infections. Many of the compositions are active against carbon monoxide dehydrogenase (“CODH”), and include substances such as antigens, antibodies specific for CODH, and other inhibitors... Agent: Novak Druce & Quigg, LLP

20070148680 - Detection of disease related genes: The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA molecules are misaminoacylated with non-radioactive markers which may be non-native amino acids, amino acid analogs or derivatives, or substances recognized by the protein synthesizing... Agent: Peter G. Carroll Medlen & Carroll, LLP

20070148678 - Device and method for carrying out a nucleic acid test, and method for producing such a device: A device and a method are disclosed for carrying out nucleic acid tests. The device includes a substrate and one or more gel pads arranged on the substrate and designed so that at least one of the biological and chemical reactions necessary for the test takes place in them, particularly... Agent: Harness, Dickey & Pierce, P.L.C

20070148666 - Diagnosis and treatment of brain cancer: Certain genes are silenced in medulloblastoma. These genes include WIF1, sFRP1 and Dkk1. By detecting the expression of at least one of these genes, it is possible to diagnose cancer or to determine whether the cancer is recurring after treatment. Diagnostic methods, methods of treatment, and kits are provided.... Agent: Viksnins Harris & Padys Pllp

20070148671 - Dna polymerase fusions and uses thereof: The present invention discloses methods of using DNA polymerase fusions at high pH in PCR, DNA sequencing and mutagenesis protocols.... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070148663 - Eb1-related compositions and methods: This invention provides an isolated polypeptide comprising all or a portion of the c-terminal domain of EB1, wherein the isolated polypeptide does not consist of residues 150-268, 219-268 or 185-268 of SEQ. ID. NO:2. This invention further provides related compositions, nucleic acids, cells and methods.... Agent: Cooper & Dunham, LLP

20070148653 - Fine metal structure, process for producing the same, fine metal mold and device: A fine metal structure having its surface furnished with microprojections of high strength, high precision and large aspect ratio; and a process for producing the fine metal structure free of defects. There is provided a fine metal structure having its surface furnished with microprojections, characterized in that the microprojections have... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070148679 - Gene set used for examination of colon cancer: Colon cancer cells in a sample are screened by analyzing the amount of expression of at least 2 or more genes or products thereof selected from the group of genes listed in Tables 1 and 30. As compared to conventional method, patients having colon cancer can be detected with higher... Agent: Fitzpatrick Cella Harper & Scinto

20070148681 - Gene synthesis kit: This disclosure is directed to the field of polynucleotide synthesis, and the embodiments taught herein are generally directed to a kit for use in the design of a desired polynucleotide from information obtained from a polypeptide or another polynucleotide, the generation of a custom set of oligonucleotides that complement the... Agent: Perkins Coie LLP

20070148668 - High-throughput assay of hematopoietic stem and progenitor cell proliferation: The present invention relates generally to assays, methods, and kits that provide reagent mixes and instructions for determining the proliferative status of isolated target cell populations. The methods measure the luminescent output derived from the intracellular ATP content of incubated target cells, and correlate the luminescence with the proliferative status... Agent: Rosenbaum & Associates

20070148684 - Immunoassay for hiv protease inhibitors: A non-isotopic immunoassay for an HIV protease inhibitor comprising incubating a sample containing the inhibitor with a receptor specific for the inhibitor or for a metabolite of said inhibitor and further with a conjugate comprising an analog of the inhibitor and a non-isotopic signal generating moiety. Signal generated as a... Agent: Roche Diagnostics Operations Inc.

20070148650 - Isolation of nucleic acid from mouth epithelial cells: The present invention is directed to a scraping instrument for collection of a biological sample, and a non-invasive method for obtaining nucleic acid from buccal mucosa epithelial cells using the scraping instrument. Such nucleic acid can be used for example for gene expression profiling, including to assess lung disease risk... Agent: Ronald I. Eisenstein

20070148692 - Kcnq potassium channels and methods of modulating same: The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present... Agent: Louis J. Wille Bristol-myers Squibb Company

20070148655 - Leucine rich repeat containing protein: This invention relates to the novel protein, termed INSP (179), herein identified as a secreted protein, in particular as a member of the leucine rich repeat containing protein family and to the use of this protein and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070148657 - Low volume hybridization: The present document relates to a system and method of commingling a low volume of a target solution with an array. For example, a quantity of the target solution and a quantity of an immiscible liquid may be introduced into a cavity having an array on an interior surface. The... Agent: Agilent Technologies Inc.

20070148661 - Lsamp gene associated with cardiovascular disease: The LSAMP gene can be used for cardiovascular disease risk assessment, in particular Left Main Disease. The genetic risk attributable to LSAMP adds to known cardiovascular disease risk factors. Assessment of risk attributable to LSAMP permits early initiation of preventive and therapeutic strategies. Given the pronounced clinical risk associated with... Agent: Banner & Witcoff, Ltd.

20070148651 - Method and kit for the isolation of rna: The present invention relates to a method and a kit for the isolation of RNA in the presence of DNA. The isolation is carried out by binding to a magnetite solid phase, where the binding buffer produces a concentration of guanidinium thiocyanate of>2.5 mol/l, and a certain concentration of phosphate... Agent: Millen, White, Zelano & Branigan, P.C.

20070148665 - Method for automatically detecting spots on a substrate: An apparatus and method for imaging metallic nanoparticles is provided. Preferably, the invention provides for an apparatus and method for detection of gold colloid particles and for accurate reporting to the operator. The apparatus includes a substrate holder for holding the substrate, a processor and memory device, an imaging module,... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070148642 - Method for detecting gene specifying allergic predisposition: A method of detecting genes which comprises detecting gene polymorphisms in allergy-predisposition-related genes; i.e., interleukin 12 receptor IL-1 β2 chain and β1 chain genes, interleukin 18 receptor α chain gene, interferon γ receptor 1 chain gene and interleukin 12.p40 subunit gene, to thereby detect allergic predisposition. Use of the present... Agent: Sughrue Mion, PLLC

20070148656 - Method for detecting the risk of cancer, coronary heart disease, and stroke by analysing a catalase gene: The present invention relates to variants in the catalase gene. The invention provides a method of identifying subject's susceptibility or predisposition to or risk of developing cancer, cancer death, CHD, and/or cerebrovascular stroke by detecting gene polymorphisms and other gene mutations in a biological sample from the subject. The invention... Agent: Birch Stewart Kolasch & Birch

20070148648 - Method for distinguishing who classified aml subtypes: Disclosed is a method for distinguishing WHO classified AML subtypes AML_MLL, t(15;17), t(8;21), inv(16), 11q23, de novo_AML, s_AML, t_AML, AML_M0, AML_M1, AML_M2, AML_M4, AML_M5a, AML_M5b, AML_M6, AML_t(15;17)/M3 and/or AML_t(15;17)/M3v in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the... Agent: Roche Molecular Systems Inc Patent Law Department

20070148644 - Method for the detection of cancer: A method for the early diagnosis, prognosis or clinical monitoring of cancer disease based on the quantitation of DNA in a plasma sample from a cancer patient, a subject with cancer susceptibility or an individual at risk of developing cancer.... Agent: Birch Stewart Kolasch & Birch

20070148641 - Method of screening for drug hypersensitivity reaction: Methods of assessing the risk of clinical signs of hypersensitivity reaction to nucleoside antiviral compounds, including abacavir, are described. The methods include genotyping subjects for polymorphisms in the TNFα gene, the class 1 HLA genes, or a combination of both the TNFα and HLA genes.... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B475

20070148667 - Methods and computer software for detecting splice variants: Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070148677 - Methods and systems for acquiring real-time quantitative melt data: Described are methods and systems for acquiring real-time quantified melt data. A first Double-stranded nucleic acid are immobilized on a support. The temperature of the double-stranded nucleic acids is slowly ramped up until the double-stranded nucleic acids melt. Differences in fluorescence emission are used to signal when the melt occurred.... Agent: Trask Britt

20070148676 - Methods for detecting gene expression in peripheral blood cells and uses thereof: The present invention relates to methods of identifying biomarkers for disease by measuring gene expression levels in subpopulations of blood cells obtained from subjects of closed populations. Particularly, the present invention relates to methods of diagnosing, monitoring and prognosing diseases by determining expression levels of disease-specific genes.... Agent: Winston & Strawn LLP Patent Department

20070148646 - Methods for relatvie quantification of specific nucleic acid sequences: This invention relates generally to a method for quantifying the number of occurrences of a specific nucleic acid sequence within a nucleic acid sample in order to circumvent the shortcomings of the methods currently available and to provide reliable quantification of a specific nucleic acid sequence within a nucleic acid... Agent: David S Resnick Nixon Peabody

20070148669 - Modified tumor necrosis factor-alpha converting enzyme and methods of use thereof: The present invention discloses a modified tumor necrosis factor-alpha converting enzyme (TACE) catalytic domain, that unlike the native TACE catalytic domain, is stable at high protein concentrations. The present invention further discloses methods for generating crystals of the modified TACE protein in protein-ligand complexes with a number of inhibitors. In... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070148664 - Modulation of skin color: The invention provides a collection of polymorphic sites associated with variations in human skin color, and genes containing or proximal to the sites.... Agent: Townsend And Townsend And Crew, LLP

20070148673 - Novel chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070148688 - Novel human enzymes of the metalloprotease family: This invention relates to newly identified polypeptides which have zinc metalloprotease activities and are referred to as IGS5, and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds which may be stimulators and/or inhibitors which are useful in therapy, to antibodies specific to such peptides, and... Agent: Crowell & Moring LLP Intellectual Property Group

20070148645 - Nucleic acid sequencing methods, kits and reagents: The present invention relates to nucleic acid sequencing methods, kits and reagents, and more particularly to methods of sequencing nucleic acid which employ a nucleic acid processing enzyme and one or more nucleotide analogues that are capable of binding to the active site of the enzyme and to complementary bases... Agent: Dann, Dorfman, Herrell & Skillman

20070148674 - Optical fingerprinting of nucleic acid sequences: The present invention provides methods and apparatus for the optical fingerprinting of nucleic acid molecules. In certain embodiments, the invention provides methods for labeling nucleic acid molecules using-site-specific nucleic acid binding partners that bind to nucleic acids without cleaving the molecule. The nucleic acid binding partners can be labeled directly... Agent: Godfrey & Kahn, S.c.

20070148659 - Pcr-based prototype kit for detecting chlamydia trachomatis and nelsseria gonorrhoeae: The invention relates to a PCR based prototype kit for detecting Chlamydia trachomatis and Neisseria gonorrhoeae comprising: a transport medium for sample collection solution A and B, a reaction mixture having the primer for Chlamydia trachomatis and Neisseria gonorrhoeae, a gel loading dye, Agarose gel, gel running buffer and a... Agent: The Webb Law Firm, P.C.

20070148654 - Process for manufacturing biochip, probe solution, and biochip: The present invention provides a process for manufacturing a biochip having high density probe regions and being resistant to contamination caused by organic materials or the like. For achieving the object, the process for manufacturing a biochip of the present invention includes a step of adhering a probe solution to... Agent: Hamre, Schumann, Mueller & Larson P.C.

20070148662 - Prostate-specific membrane antigen: This invention provides an isolated mammalian nucleic acid molecule encoding a mammalian prostate-specific membrane antigen. This invention also provides prostate-specific membrane nucleic acid of at least 15 nucleotides capable of specifically hybridizing with a sequence of a nucleic acid molecule encoding a mammalian prostate-specific membrane antigen. This invention further provides... Agent: Cooper & Dunham LLP

20070148682 - Protein fragment complementation assays for the detection of biological or drug interactions: We describe a strategy for designing and implementing protein-fragment complementation assays (PCAs) to detect biomolecular interactions in vivo and in vitro. The design, implementation and broad applications of this strategy are illustrated with a large number of enzymes with particular detail provided for the example of murine dihydrofolate reductase (DHFR).... Agent: Isaac A. Angres

20070148686 - Protein present at the surface of hematopoietic stem cells of the lymphoid line and of nk cells, and uses thereof: The invention concerns a protein present at the surface of hematopoietic stem cells of the lymphoid cell line and mature NK cells, the corresponding isolated cDNA sequence and their uses as marker of said cells and for preparing antibodies directed against said protein. The invention also concerns the uses of... Agent: Alston & Bird LLP

20070148647 - Purification methods: The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group. The general concept being illustrated by the scheme:... Agent: Ge Healthcare, Inc.

20070148652 - Reagent for detecting an analyte: e

20070148675 - Structure designed for adsorption of dna intercalators: Provided is a structure designed for adsorption, which is suitable for removing dioxin and dioxin-like substances from leachate and ground water from polluted soils or garbage, washing effluent from garbage incinerators and so on that contain DNA intercalators, particularly, dioxin and dioxin-like substances. The structure designed for adsorption is a... Agent: Fitzpatrick Cella Harper & Scinto

20070148672 - System and method of facilitating animal propagation: The present invention provides a system and method of facilitating animal propagation. In one embodiment, the present invention utilizes data relating to the traits or characteristics of existing animals organized into various cow-bull pairs to predict the degree that those traits or characteristics will be exhibited by the offspring of... Agent: Daniel D. Chapman Jackson Walker, LLP

20070148643 - Treatment of huntington's disease with epa: Analysis of the huntington gene provides a method for identifying patients likely to respond to treatment of Huntington's disease with eicosapentaenoic acid, EPA.... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20070148660 - Treatment of maladaptive substance use with h-ras antagonists: The present invention provides a method of mitigating a symptom of maladaptive substance use in a subject by inhibiting H-ras. In addition, the invention provides a variety of prescreening and screening methods aimed at identifying agents that modulate a symptom of maladaptive substance use. Methods of the invention can involve... Agent: Quine Intellectual Property Law Group, P.C.

20070148691 - Use of nrg4, or inhibitors thereof, in the treatment of colon and pancreatic cancers: This invention relates to compositions and uses of NRG4, and to variants thereof and to polynucleotides encoding NRG4, for therapeutic and diagnostic purposes, particularly related to colon and pancreatic cancer. This invention also relates to therapeutic agents based on or derived from the polynucleotides and proteins, NRG4 inhibitors, particularly antibodies... Agent: Novartis Vaccines And Diagnostics, Inc. Corporate Intellectual Property-r338

20070148687 - Variable valve apparatus and methods: Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a... Agent: 3m Innovative Properties Company

20070148693 - Circular recombinant plasmid dna constructs and their protein products, methods of preparation and immobilisation of proteins on support: The invention relates to new circular recombinant plasmid DNA constructs and their protein products, to the use of said protein products in immobilisation, visualisation and quantification of enzymes and proteins on compatible support material. The invention also relates to a method of preparation and immobilisation of the protein on a... Agent: Ladas & Parry

20070148698 - Composite microarray slides: Improved composite microarray slides for use in micro-analytical diagnostic applications are disclosed. Specifically, composite microarray slides useful for carrying a microarray of biological polymers on the surface thereof including composite microarray slides having a porous membrane formed by a phase inversion process effectively attached by covalent bonding through chemical agents... Agent: 3m Innovative Properties Company

20070148696 - Highly-selective tandem chemical sensor and detection method using same: The invention relates to a chemical sensor intended for the detection of a type of molecule comprising a fluorescent material capable of forming a charge transfer complex with the type of molecule to be detected and means for measuring the variation in fluorescence of said material, characterized in that it... Agent: Lowe Hauptman Gilman & Berner, LLP

20070148701 - Immunological assay system and method: An immunological or immunohematological assay system is disclosed that includes a filter vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition system, and a robotic pipettor. The immunological assay system may also include a washer. Also disclosed is an immunological assay method that... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070148694 - Mass-based toxin assay and substrates therefor: An assay for a metalloprotease comprises (i) combining a test compound with a substrate, wherein the protease reacts with the substrate to form a product; and (ii) detecting presence of the metalloprotease by measuring the mass of the product.... Agent: Evan Law Group LLC

20070148702 - Measuring chip for surface plasmon resonance biosensor and method for producing the same: An objective of the present invention is to provide a measuring chip for a surface plasmon resonance sensor that can detect a small amount of target substances in high sensitivity. The present invention provides a measuring chip for a surface plasmon resonance sensor comprising a metal layer, one or more... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070148699 - Method for deriving a wellness related index for a food composition: A method for deriving a wellness related index for a composition for consumption by an animal by (a) evaluating an effect of the composition, relative to the effect of one or more comparative compositions, on each of a plurality of parameters indicative of the health or wellness of the animal;... Agent: Colgate-palmolive Company

20070148697 - Methods and system for high throughput screening of polymer materials for medical devices: The present invention provides a system for high-throughout analysis of a polymeric formulation for implantable and insertable medical devices comprising a plurality of dots arranged to form an array on a substrate having at least an x axis and y axis, each dot comprising a polymeric composition and wherein a... Agent: Mayer & Williams PC

20070148695 - Optically encoded particles, system and high-throughput screening: The invention concerns a particle having a code from a library of codes embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum.... Agent: Greer, Burns & Crain

20070148700 - Site-specific aminoglycoside derivatives for use in immunodiagnostic assays: A method of making a derivatized aminoglycoside includes reacting an aminoglycoside with at least 2 equivalents of a divalent metal ion in an aprotic solvent to complex two neighboring amino group and hydroxyl group pairs; reacting the non-complexed amino groups with a protecting reagent to provide protecting groups; removing the... Agent: Brinks Hofer Gilson & Lione

20070148704 - Anti-ccpand antinuclear antibodies in diagnosis of rheumatoid arthritis: The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in the differential diagnosis of rheumatoid arthritis in vitro. The method is for example practiced by analyzing biochemical markers, comprising measuring in a sample both the concentration of anti-CCP and of... Agent: Roche Diagnostics Operations Inc.

20070148703 - Method of screening remedy for breast cancer: The present invention is a method for screening a remedy for breast cancer which does not require uptake into cells unlike aromatase inhibitors, estrogen sulfatase inhibitors, or estrogen competitive inhibitors such as tamoxifen and toremifene, and which shows excellent drug delivery property and extremely rare adverse effect. In the method,... Agent: Alston & Bird LLP

20070148706 - Pancreatic progenitor cells and methods for isolating the same: The invention provides animal models, where the ectopic expression of KGF, EGF, or both is under the control of a pancreas-specific promoter, e.g., the insulin promoter. The expression of KGF in the ins-KGF pancreatic islets of Langerhans results in enlarged islets, with substantial proliferation of duct cells within the islet... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070148705 - System and method for qualifying a logic cell library: A system and a method for qualifying a logic cell library storing process parameters and properties of a specific semiconductor FAB when the logic cell library is newly developed or modified is provided. The system for qualifying a logic cell library which qualifies a new library and a modified library,... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070148712 - Breast cancer and prostate cancer assessment: A method for detecting a biological marker in a sample, which comprises a complex mixture of molecules, from a patient comprising exposing a detection site having bound monoclonal antibodies specific for the biological marker to the sample, exposing the detection site to a detectably labeled reporter molecule, which is substantially... Agent: Barnes & Thornburg LLP

20070148714 - Clinical parameters for determining hematologic toxicity prior to radioimmunotherapy: New clinical parameters are reported which may serve as predictors of the hematological toxicity associated with therapeutic radiolabeled antibodies, particularly those antibodies which target lymphoma cells which have a tendency to localize to the bone marrow.... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20070148710 - Cpt resistant cell line: Disclosed are compositions relating to cells and cell lines that are resistant to a given chemotherapeutics as well as method for making and using the same.... Agent: Fish & Richardson P.C.

20070148711 - Identification of non-small cell lung carcinoma (nsclc) tumors expressing pdgfr-alpha: The invention discloses a previously unidentified subset of mammalian non-small cell lung carcinomas (NSCLC) in which platelet-derived growth factor receptor alpha (PDGFRα) is expressed and is driving the disease, and provides methods for identifying a mammalian NSCLC tumor that belongs to a subset of NSCLC tumors in which PDGFRα is... Agent: James Gregory Cullem, Esq. Intellectual Property Counsel

20070148713 - Protein markers for esophageal cancer: Computerized analysis of 2-D gels, both carrier ampholyte (CA) and immobilized pH gradient (IPG) based, of the proteins in tissue from esophageal tumors, reveals proteins which are different in tumor and control tissue.... Agent: Arent Fox PLLC

20070148716 - Device for monitoring a patient for a urinary tract infection: The invention provides for a urinary monitoring device to monitor for the presence or absence of markers indicative of a urinary tract infection (UTI). The invention also provides for methods of using such a device.... Agent: Fish & Richardson P.C.

20070148715 - Method for detecting transient ligand interactions: The invention relates to methods and kits for separating, and optionally analyzing, substoichiometrically interacting ligands from a high abundance ligand of interest in an affinity matrix system. The methods comprising immobilizing a complex of a first and second ligand to an affinity matrix, wherein the second ligand is bound to... Agent: Bereskin And Parr

20070148717 - Sensitive immunochromatographic assay: Methods for quantitatively measuring the amount of an analyte of interest in a fluid sample, and kits useful in the methods, are disclosed. The methods involve providing a solid phase apparatus comprising a membrane having an application point, a sample capture zone, and a control capture zone, where the sample... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070148709 - Molecular tag reader: Near-infrared molecular assays can be used to detect small quantities of a molecule of interest in vivo or in vitro using laser dyes. A hand-held portable device is provided which can rapidly read small quantities of selected molecular tags in tissues of fish or other animals in the field. The... Agent: U.s. Army Space And Missile Defense Command

20070148708 - Protease inhibitor conjugates and antibodies useful in immunoassay: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavor. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal... Agent: Marilyn L. Amick Roche Diagnostics Corporation

20070148707 - Systems and methods for detection of analytes in biological fluids: The invention provides a heterogeneous immunoassay for detection of antibodies and antigens based on specific antigen-antibody immune complex formation with multiple antigen-bearing conjugate components. The invention further provides means for optimizing the assay format for the detection of both low and high-affinity antibodies, and provides means for quantitative detection of... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070148718 - Fas binding antibodies: The disclosed invention relates to monoclonal antibodies (MAbs) which recognize human fatty acid synthase (hFAS) and are distinct from previously known anti-hFAS antibodies. Compositions, devices and kits comprising the MAbs are provided along with methods of using the MAbs in a variety of applications.... Agent: Townsend And Townsend And Crew, LLP

20070148721 - Compositions, methods, systems, and kits for affinity purification: The invention provides a method of separating proteins and peptides of a sample comprising contacting the sample with a Pd coordination compound. The Pd coordination compound binds to sulfur and/or nitrogen groups and thus is useful for purifying biomolecules comprising cysteine, methionine, histidine amino acids or derivatized amino acids/residues comprising... Agent: Agilent Technologies Inc.

20070148722 - Method for determining the concentration of thrombin inhibitors: The invention relates to a method for determining the concentration of thrombin inhibitors in a non-turbid body liquid or a non-turbid extract from a body liquid. It comprises the following steps. The body liquid is taken from a living body, and the body liquid is subjected to a separation from... Agent: Millen, White, Zelano & Branigan, P.C.

20070148720 - Method of identifying protein with the use of mass spectometry: The present invention provides an approach for identifying with high accuracy, a known protein or a variant of the known protein derived from the same genomic gene as in a target protein to be analyzed, based on a mass spectrometric result of a plurality of peptide fragments obtained from site-specific... Agent: Dickstein Shapiro LLP

20070148724 - Inhibition assay method and device for detection of antibiotics: An aspect of the disclosure is a method and device for the detection of antibiotics in a sample. Embodiments include a microbial culture with growth indicators and sensitivity adjustment reagents. Adjustment reagents include a variety of antibiotic binders that can be added to microbial culture to reduce sensitivity to certain... Agent: Charm Sciences Inc Richard J Long

20070148725 - Soil microorganism-housing biosensors and their uses: Microorganism sensors used in environment assessment technologies and the like, instead of being used to detect environmental components and determine their concentrations, were used as tools to evaluate the ability of target soil microorganisms to adapt to various field soil environments, and comparative studies were performed. As a result, the... Agent: Nixon Peabody LLP - Patent Group

20070148726 - Cell culture and mixing vessel: A mixing vessel (10) for containing a liquid, comprises a chamber having a lower chamber portion and an upper chamber portion wider than the lower portion, gas inlet means (14) for supplying gas to the lower portion and means for redirecting rising gas (24), such that, in use, rising gas... Agent: Morgan Lewis & Bockius LLP

20070148727 - Novel carotenoid hydroxylase gene, method for preparing hydroxylated carotenoid, and novel geranylgeranyl pyrophosphate synthase: The present invention provides a Brevundimonas sp. strain SD212-derived peptide having β-ionone ring-2-hydroxylase activity and a gene encoding the same, to thereby make it possible to produce rare carotenoids in which a hydroxyl group is introduced at the position 2 (2′) carbon in their β-ionone ring in large quantities. The... Agent: Birch Stewart Kolasch & Birch

20070148728 - Synthesis of oligosaccharides, glycolipds, and glycoproteins using bacterial glycosyltransferases: This invention provides nucleic acid and amino acid sequences of fucosyltransferases from Helicobactor pylori. The invention also provides methods to use the fucosyltransferases to synthesize oligosaccharides, glycoproteins, and glycolipids.... Agent: Townsend And Townsend And Crew, LLP

20070148736 - Apparatus and method for separating viral particles from cells: A method for analyzing a sample to detect cells infected by Human Papilloma Virus (HPV) is provided. The method includes passing a medium containing the sample across a filter. The filter has a pore size that is greater than a dimension of a HPV particle, but smaller than a dimension... Agent: Cytyc Corporation

20070148731 - Efficient protein expression system: Nucleic acid expression control sequence cassettes and vectors containing the same are provided for use in making abundant quantities of recombinant polypeptides of interest. The modified transcriptional control sequences, which include a T5 promoter sequence, are highly stable and can be used in a variety of vectors, such as plasmids.... Agent: Seed Intellectual Property Law Group PLLC

20070148734 - Hyaluronic acid mediated adenoviral transduction: The present invention provides methods of treatment of adenoviral mediated disease, improved methods for transducing cells with adenoviral and related vectors, and improved methods of gene therapy utilizing such methods.... Agent: Fulbright & Jaworski, L.L.P.

20070148737 - Materials and methods for the purification of polyelectrolytes, particularly nucleic acids: The present invention provides novel rapidly growing microorganisms and methods for their use in cloning or subcloning nucleic acid molecules. The rapid growing microorganisms of the present invention form colonies more rapidly than microorganisms typically used in molecular biology and thus provide a significant improvement in in vitro cloning methods... Agent: Invitrogen Corporation C/o Intellevate

20070148729 - Methods for increasing neisseria protein expression and compositions thereof: The present invention broadly relates to polynucleotide sequences encoding porin polypeptides of Neisseria. More particularly, the invention relates to newly identified nucleic acid sequence mutations in polynucleotides encoding PorA polypeptides of Neisseria meningitidis, wherein these sequence mutations result in increased expression levels of PorA polypeptides.... Agent: Hunton & Williams LLP Intellectual Property Department

20070148735 - Novel chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070148732 - Novel enzymes: The present invention relates to novel cellulase enzymes, especially novel endoglucanases including endoglucanase fusion proteins, preparations and compositions containing these endoglucanase enzymes and fusion proteins, expression vectors, host cells and methods for their preparation and uses of the cellulases, preparations and compositions in the textile, detergent and pulp and paper... Agent: Banner & Witcoff, Ltd.

20070148730 - Superactive cellulase formulation using cellobiohydrolase-1 from penicillium funiculosum: Purified cellobiohydrolase I (glycosyl hydrolase family 7 (Cel7A) enzymes from Penicillium funiculosum demonstrate a high level of specific performance in comparison to other Cel7 family member enzymes when formulated with purified EIcd endoglucanase from A. cellulolyticus and tested on pretreated corn stover. This result is true of the purified native... Agent: Paul J White National Renewable Energy Laboratory

20070148738 - Transcriptional regulator: Genes each encoding a novel transcriptional regulator having a bromodomain have been successfully isolated from a human testis cDNA library using primers prepared based on an EST sequence found using the bromodomain sequence of the transcriptional regulator. These genes are structurally analogous to each other.... Agent: Fish & Richardson PC

20070148733 - Yeast expression vectors for production of itf: The invention features ITF expression vectors and methods of producing ITF.... Agent: Clark & Elbing LLP

20070148739 - Fusion proteins of interferon alpha muteins with improved properties: The invention concerns human interferon alpha and in particular modified forms of interferon alpha 2 with improved properties. The improved proteins contain amino acid substitutions at specific positions that confer increased relative activity in biological assays. The invention provides also modified interferon alpha with improved biological activity concomitant with reduced... Agent: Olson & Hierl, Ltd.

20070148740 - Chondroitinase abc i and methods of degrading therewith: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans... Agent: Wolf Greenfield & Sacks, P.C.

20070148741 - Mashing process: The present invention relates to a mashing and filtration step in a brewing process and to a composition useful in the mashing and filtration step of a brewing process. The mash is prepared in the presence of enzyme activities comprising a xylanase of GH family 10.... Agent: Novozymes North America, Inc.

20070148742 - Process for the production of amino acids: The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070148743 - Microbiological method for producing amides: The present invention provides for microorganisms capable of tolerating acetonitrile concentrations of at least 3 M, enzyme extracts obtainable from these microorganisms, a nitrile hydratase obtainable from these microorganisms, a method for preparing amides using these microorganisms, the enzyme extracts or the nitrile hydratase obtainable therefrom, and a method for... Agent: Nixon & Vanderhye, PC

20070148744 - Bafilomycin-like metabolite from a novel micromonospora species: The invention provides a compound of formula (I) and pharmaceutically acceptable salts thereof. Processes for the isolating of this bafilomycin metabolite from a novel Micromonospora species, pharmaceutical compositions containing this metabolite and methods of treatment using said metabolite are also described.... Agent: Philip S. Johnson Johnson & Johnson

20070148747 - Genes involved in polyketide synthase pathways and uses thereof: The subject invention relates to isolated nucleic acid sequences or genes involved in polyketide synthase (PKS) biosynthetic pathways. In particular, such pathways are involved in the production of polyunsaturated fatty acids (PUFAs) such as, for example, Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA). Specifically, the invention relates to isolating nucleic... Agent: Robert Deberardine Abbott Laboratories

20070148746 - Process for the enzymatic synthesis of triglycerides: The invention relates to a process for the enzymatic synthesis of esters of polyunsaturated, short-chain or sensitive fatty acids with a high triglyceride content, which is made up of an enzymatic synthesis of the mixture of triglycerides and partial glycerides starting from free fatty acid, methyl or ethyl esters and... Agent: Cognis Corporation Patent Department

20070148745 - Process for the production of diacylglycerol: The present invention provides a process for producing a diacylglycerol, which comprises, reacting triacylglycerol with water and an enzyme to obtain a mixture comprising of diacylglycerol, monoacylglycerol and free fatty acid; removing water content in the mixture by way of dehydration; and separating monoacylglycerol, free fatty acid and residual triacylglycerol... Agent: Nath & Associates

20070148748 - Fermentation process using specific oxygen uptake rates as a process control: Specific oxygen uptake (OUR) is used as a process control parameter in fermentation processes. OUR is determined during at least the production phase of a fermentation process, and process parameters are adjusted to maintain the OUR within desired ranges. The invention is particularly applicable when the fermentation is conducted using... Agent: Gary C. Cohn, PLLC

20070148749 - Process for producting 1,3-propanediol and or/3-hydroxypropionic acid: This invention is intended to improve the efficiency of producing 1,3-propanediol from glycerol and to provide an industrially effective process for producing the same. Such process involves the use of a transformant comprising the gene encoding the large subunit of glycerol dehydratase and/or diol dehydratase, the gene encoding the medium... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070148750 - Method for producing monosaccharides from biomass and monosaccharide production device: This monosaccharide production method is a method for producing monosaccharides from biomass having a first step 3 in which a raw material biomass is pretreated in 65 to 85 (w/w) % sulfuric acid at a temperature of 30 to 70° C., and a second step 4 in which the first... Agent: Darby & Darby P.C.

20070148751 - Method of processing lignocellulosic feedstock for enhanced xylose and ethanol production: The present invention provides a method of producing xylose from lignocellulosic feedstock. The method comprises disrupting lignocellulosic feedstock; leaching the lignocellulosic feedstock by contacting the feedstock with at least one aqueous solution for a period greater than about 2 minutes to produce a leached feedstock and a leachate; removing the... Agent: Brinks Hofer Gilson & Lione

20070148752 - Sulfated fucogalactan digesting enzyme gene: A gene encoding a polypeptide having an activity of digesting sulfated fucogalactan which is useful in sugar chain engineering reagents, analyzing the structures of sulfated fucose-containing polysaccharides and preparing degraded products of the polysaccharides; a genetic engineering process for producing the polypeptide; and the polypeptide obtained by the process.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070148753 - Preparation of cells for production of biologicals: The present invention relates to a method for the preparation of cells for use in the production of biologicals, by culturing cells up till a desired cell volume of a preproduction batch, where after in a repeated discontinous process: a) part of the cells of the preproduction batch is used... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070148754 - Methods and compositions for improving plant growth: The present invention has surprisingly discovered that certain spore-forming microorganisms, present in soil, plants and other forms of organic matter, survive excessive heat of a fire within soil or carbonized wood. It has been determined that such microorganisms stimulate plant growth, enhance the nutritional value of plant products, and incorporate... Agent: Scully Scott Murphy & Presser, PC

20070148755 - Biocontrol formulation containing streptomyces spp., method for preparing the formulation and relevant use: The present invention is a method for preparing a biocontrol formulation by the following steps. A Streptomyces bacterium is selected simultaneously with superior sporulation ability, chitinase activity and antagonistic effectiveness against plant fungal pathogens by culturing with fungal pathogens, wherein the selected Streptomyces bacterium is cultured on a chitin-limited plate... Agent: Nikolai & Mersereau, P.A.

20070148756 - Tissue dissociation device: A tissue dissociation device (10) includes a container (12) having a sterile interior for holding the tissue to be dissociated and a liquid medium. The device (10) also includes a dissociation element (54), inside the container (12), for engaging the tissue to cause dissociation of the tissue. The device (10)... Agent: Battelle Memorial Institute

20070148758 - Electrofusion microelectrode: The present invention is directed to an electrofusion microelectrode used in the alignment, manipulation, fusion, or electroporation of cells. This device is particularly useful for transplantation of cells and cellular components.... Agent: Nixon Peabody LLP - Patent Group

20070148757 - Electrofusion microelectrode and methods of using it to manipulate cells and/or cellular components: The present invention relates to an electrofusion microelectrode made of a tube having a first proximal end and a second distal end. The tube has an electrically conductive coating on its exterior surface that extends continually from the first proximal end of the tube toward the second distal end of... Agent: Nixon Peabody LLP - Patent Group

20070148759 - Biological sample discrimination device, biological sample discriminating method, and biological sample discriminating plate: There is provided a plate (10) on which a channel pattern (110) is formed, which channel pattern includes a first channel (116) into which a buffer agent is injected, and a second channel (117) having, in a portion thereof, a quantification part (117a) that has a portion common to the... Agent: Wenderoth, Lind & Ponack L.L.P.

20070148761 - Instrument for monitoring polymerase chain reaction of dna: An optical instrument monitors PCR replication of DNA in a reaction apparatus having vials of reaction ingredients. A beam splitter passes an excitation beam to the vials. An emission beam from the reaction ingredients can be passed by the beam splitter to a detector from which a processor can compute... Agent: Kilyk & Bowersox, P.l.l.c.

20070148760 - Obtaining analyte information: Light, such as from an analyte-wavelength converter or other optical sensor, is propagated to a detector or transmission structure with an entry surface and with output positions such as in an exit surface. For example, the position of light output by such a detector can be used to detect presence... Agent: Leading Edge Law Group, PLC/xerox-parc

20070148763 - Quantitative cell dispensing apparatus using liquid drop manipulation: Provided is a quantitative cell dispensing apparatus using liquid droplet manipulation, for quantitatively dispensing cells from hydrophilic suspension containing a plurality of cells. The quantitative cell dispensing apparatus includes hydrophilic suspension, a liquid droplet manipulation unit, a dispensing unit, a sensing unit, and a control unit. The hydrophilic suspension includes... Agent: Cantor Colburn, LLP

20070148762 - Cell culture patterning substrate: A cell culture patterning substrate on which cells can be arranged regularly with high efficiency over a large area on a base material so as to attain formation of a tissue, etc. The cell culture patterning substrate includes: a base material; and a cell culture region which is formed on... Agent: Ladas & Parry LLP

20070148764 - Device for cell culture: A device for cell culture capable of automatically performing operations for cell culture over several days to several months while minimizing the risk of contamination. A new medicine can be supplied to an incubator means by using a medicine supply means or unnecessary wastewater can be discharged from the incubator... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070148765 - Preservative-containing virus formulations: The preservation of live viral vaccines is disclosed. These liquid formulations comprise a live virus and a preservative, namely chlorobutanol. The preserved, live virus formulations of the present invention are (1) suitable for a vaccine or gene therapy product with a multi-dose image; (2) compatible with parenteral administration; and (3)... Agent: Merck And Co., Inc

20070148770 - Macroporous chitosan beads and preparation method thereof: The present invention relates to macroporous chitosan beads having 5-200 μm in size of relatively large and uniform pores that are distributed from surface to core region. The macroporous chitosan beads of the present invention make cell culturing efficient. Cells can attach to them efficiently due to their large surface... Agent: Jhk Law

20070148766 - Method and system for preparing stem cells from fat tissue: The present invention provides a method for preparing homogeneous stem cells and/or precursor cells in a large amount, in a simple and efficient manner, from human (in particular, the subject per se). The present invention further provides a method for preparing tissue implant or graft in a large amount by... Agent: Seed Intellectual Property Law Group PLLC

20070148767 - Method of forming multicellular spheroids from the cultured cells: Provided herein are methods for producing multicellular spheroids or embryoid bodies suitable for providing cells in large scale for various medical applications. In one embodiment, a method of forming embryoid bodies is provided, which comprises culturing undifferentiated HES cells in a culture vessel pre-coated with cellulose and/or its derivatives. In... Agent: Rabin & Berdo, P.C. Suite 500

20070148769 - Methods and devices for the long-term culture of hematopoietic progenitor cells: The invention pertains to methods and devices for the long term, in vitroculture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors, improved methods for the introduction of foreign genetic material into cells of hematopoietic origin, and to apparatus for performing these methods. The hematopoietic progenitor... Agent: Wolf Greenfield & Sacks, P.C.

20070148771 - Reconstructed epidermis/skin equivalent comprising a ceramide 7 and/or 5.5 and lipid lamellar vesicular compositions comprising ceramide 7 and/or 5.5 compounds: A reconstructed epidermis/skin equivalent supplemented with at least one ceramide 7 and/or 5.5 compound, suited for reinforcing the barrier function of normal human epidermis and for improving the barrier function of dry skin and of reconstructed skin or skin equivalents, is prepared by introducing the at least one ceramide 7... Agent: Buchanan, Ingersoll & Rooney PC

20070148768 - Surface modification of polysaccharide, the modified polysaccharide, and method of culturing and recovery cells using the same: A surface modification method of polysaccharide, the modified polysaccharide, and a method of culturing and recovery cells using the same are provided. The surface modification method of polysaccharide comprises (a) immersing a polysaccharide material in an acid, (b) immersing the polysaccharide material in an acidic solution containing a protein, and... Agent: Birch Stewart Kolasch & Birch

20070148772 - Leukocyte cell banks: The invention relates to a novel form of leukapheresis (isolated leukapheresis), to processes and apparatus for carrying out isolated leukapheresis, to leukocyte cell banks created thereby and to various forms of therapy based thereon.... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20070148773 - Sequence specific dna recombination in eukaryotic cells: The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA comprising a nucleotide sequence containing at least one further recombination sequence... Agent: Fulbright & Jaworski L.L.P.

20070148774 - Methods for producing members of specific binding pairs: A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are displayed in functional form at the surface of a secreted recombinant genetic display package (rgdp) containing DNA encoding... Agent: Howrey LLP

20070148775 - Method for cloning and expressing target gene by homologous recombination: A method for cloning and expressing a target gene by homologous recombination, and more particularly a method for cloning and expressing a target gene by homologous recombination, wherein a host cell transformed with a recombinant vector and a plasmid containing a recombinase system is introduced with a linear DNA fragment... Agent: Intellectual Property / Technology Law

20070148776 - Method capable of increasing competency of bacterial cell transformation: The invention concerns bacterial strains capable of enhanced transformation efficiencies that are produced by the introduction of the F′ genetic material. The invention also concerns processes for producing transformable competent bacteria with enhanced transformation efficiencies.... Agent: Invitrogen Corporation C/o Intellevate

  
06/21/2007 > patent applications in patent subcategories. archive of inventions by patent app class

20070141562 - Apparatus and methods for high yield microbial surface sampling: This invention discloses an apparatus and methods for high yield microbial surface sampling. The microbial sampling techniques in which a sample is obtained from an environmental or biological surface using a microfiber material in the form of microfiber devices, wipes, or swabs.... Agent: Thomas H. Grove

20070141559 - Methods for detecting and typing herpes simplex virus: Detailed herein are methods of detecting herpes simplex virus and differentiating between types 1 and 2 by simultaneous detection of type-specific gene sequences. In particular aspects, individuals infected with HSV-1 can be distinguished from those infected with HSV-2 by amplification and detection of the HSV-1 glycoprotein B gene or the... Agent: Foley & Lardner LLP

20070141584 - Methods for assessment of native chromatin on microarrays: A method for determining chromatin accessibility of nucleic acids in a cell by expressing an effective amount of a nuclease in a cell to digest chromatin at chromatin accessible sites to form chromatin fragments; isolating chromatin fragments from the cell; and hybridizing the chromatin fragments on a microarray to determine... Agent: Agilent Technologies Inc.

20070141583 - Methods of rapid chromatin immunoprecipitation: This invention is related to a method for rapidly identifying regions of the genome to which specific proteins bind, or identifying specific proteins bound to a region of the genome in vivo.... Agent: Jessica M. Li

20070141678 - Processes for purifying oligosaccharides: Processes for purifying oligosaccharides including contacting a basic oligosaccharide solution with a basic boronate resin to bind monosaccharides to the basic boronate resin and obtain a purified oligosaccharide solution. The basic boronate resin can bind about 50% of the monosaccharides and about 10% of oligosaccharides in the basic oligosaccharide solution,... Agent: The Procter & Gamble Company Intellectual Property Division - West Bldg.

20070141548 - Organ transplant solutions and method for transplanting organs: A preservation solution for organs waiting to be transplanted is disclosed; the method of using the solution in a transplantation procedure is also disclosed. The preservation solutions comprise a balanced isotonic aqueous solution comprising sodium, potassium, calcium, magnesium and bicarbonate ions in a physiologically acceptable amount, together with an effective... Agent: Frost Brown Todd, LLC

20070141552 - Automatable artificial immune system (ais): The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates... Agent: Merchant & Gould PC

20070141551 - Compositions and methods for lipoprotein uptake assays: Provided herein are compositions and methods for lipoprotein uptake assay. These compositions and methods may be used for the lipoprotein uptake assays, including high-throughput assays. The disclosed compositions and method may further be used to characterize the activity agents that inhibit or stimulate lipoprotein uptake.... Agent: General Electric Company Global Research

20070141555 - Current damper for the study of cells: A device for the study of cells including a vessel with a current damper including a damping component substantially disposed within the vessel is disclosed. The damping component reduces or eliminates currents formed by the addition of materials such as liquids to the vessel to prevent the movement of cells... Agent: Martin D. Moynihan Prtsi, Inc.

20070141550 - Immobilized-enzyme microreactor devices for characterization of biomolecular analytes and associated methods: A method that comprises providing a polymerized sol-gel material (PSG) and linking an enzyme to a surface of the PSG via covalent linkage is provided. The surface of the PSG is derivatized with a linker that comprises a functional group for linking itself to the surface of the PSG and... Agent: Parsons Hsue & De Runtz LLP

20070141553 - Method and biochip for studying a chemical sample: A method for studying a biological sample in a biochip (“lab-on-a-chip”) is disclosed. In at least one embodiment of the method, a biological sample is introduced into the biochip, the sample is subjected to at least one preparation step and, at the end of a measurement cycle, the concentration of... Agent: Harness, Dickey & Pierce, P.L.C

20070141556 - Method for immobilizing a biomolecule on a solid substrate at a high density by using the substrate having an active carboxyl group on a surface thereof and microarray produced using the method: Provided is a method for immobilizing a biomolecule on a solid substrate. The method includes coating the solid substrate with silane anhydride to introduce an anhydride functional group onto a surface of the solid substrate; obtaining a carboxyl group from the anhydride functional group by hydrolysis; reacting the carboxyl group... Agent: Cantor Colburn, LLP

20070141554 - Stable cell lines expressing herg: A stable eukaryotic cell line that expresses hERG and exhibits a stable current under electrophysiological test conditions is provided.... Agent: Roche Palo Alto LLC Patent Law Dept. M/s A2-250

20070141549 - Test system for the evaluation of a coating to biofouling and fluid shear forces: Described is a test system for the evaluation of a coating to biofouling and fluid shear forces in natural seawater, comprising: a support structure for holding test panels, a first array of separate, spaced apart test panels being arranged on the support structure (a) in two or more coaxial circles... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20070141563 - Control for nucleic acid testing: The present invention is related to a method for detecting a target biomolecule in test sample by adding an internal control biomolecule to the test sample; to a negative control sample, to a positive control sample and to a reagent control sample or adding an internal control biomolecule to the... Agent: Roche Molecular Systems Inc Patent Law Department

20070141557 - Method and device for optimizing a nucleotide sequence for the purpose of expression of a protein: The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is... Agent: Pillsbury Winthrop Shaw Pittman LLP

20070141564 - Method for the rapid diagnosis of targets in human body fluids: More particularly, the present invention relates to a method for the detection of a target, e.g. pathogen in a human body fluid wherein a body fluid sample is collected with a swab member.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070141561 - Microfluidic device and method for concentration or purification of sample containing cells or viruses: A microfluidic device for concentrating or purifying a sample containing cells or viruses including a sample circulating vessel having a constant capacity; a pump connected to the sample circulating vessel and a trapping unit located in the sample circulating vessel. A method of concentration or purifying a sample containing cells... Agent: Cantor Colburn, LLP

20070141565 - Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome: The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy. According to the invention, polymerase chain reaction assays may be used to predict immunological decline and to identify, at an early stage, patients whose... Agent: Howrey LLP

20070141560 - Probes and methods for hepatitis c virus typing using multidimensional proble analysis: This invention provides compositions and methods for HCV typing, e.g., genotyping and/or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at least five HCV types (for example, selected from types 1, 2, 3, 4, 5 or 6), or to... Agent: Quine Intellectual Property Law Group, P.C.

20070141558 - Quantitative assay for detection of newly synthesized rna in a cell-free system and indentification of rna synthesis inhibitors: Methods for detecting populations of newly synthesized and newly initiated RNAs in a cell-free system are described. Suitable templates for the populations of newly synthesized and newly initiated RNAs are viral replicon RNAs, particularly HCV viral replicon RNA. The newly synthesized and newly initiated RNAs may be formed in the... Agent: Cantor Colburn, LLP

20070141586 - Abasic site endonuclease assay: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.... Agent: Townsend And Townsend And Crew, LLP

20070141585 - Altered gene expression profiles in stable versus acute childhood asthma: Differences in gene expression in control and asthma patients to profile, differentiate, evaluate, etc. patients with exacerbated asthma and stable asthma.... Agent: Wood, Herron & Evans, LLP

20070141593 - Apparatus, system, and method using immiscible-fluid-discrete-volumes: Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic... Agent: Leonard D. Bowersox

20070141570 - Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods: Polymorphic A-kinase anchor proteins (AKAPs) and nucleic acids encoding the proteins are provided herein. Methods of detecting polymorphic AKAPs and nucleic acids encoding the AKAPs, and kits for use in the detection methods are also provided. Further provided herein are methods of identifying subjects having or at risk of developing... Agent: Grant Anderson LLP C/o Portfolioip

20070141576 - Biological chip and use thereof: A biological chip includes probes immobilized on a circumferential side wall of a discoidal or cylindrical substrate. The probes contain a nucleic acid, a peptide, a saccharide, a lipid, a chemical substance, or a fragment thereof. The disc or cylinder is rotated so as to attain rapid intake of massive... Agent: Young & Thompson

20070141597 - Biomimetic biodetector of toxins, viruses, bacteria, and biological factors: A method for detecting a target agent in an environment is disclosed. The method includes preparing a biomimetic ligand, the ligand providing a site at which the target agent will bind. The method also includes covalently bonding a colorimetric indicator with the biomimetic ligand on a non active site of... Agent: Fellers Snider Blankenship Bailey & Tippens

20070141622 - Buffers for electrophoresis and use thereof: Various embodiments provide, for example, buffer compositions and/or sieving formulations useful in connection with electrophoresis instruments, such as capillary electrophoresis (CE) devices. In various embodiments, a buffer composition can include Bis-Tris, TAPS and/or TAPSO, and, optionally, a chelating agent, such as EDTA. Methods of separating samples containing bio-molecules, such as... Agent: Knobbe Martens Olson & Bear LLP

20070141608 - Chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070141573 - Complement inhibitors: The invention relates to complement inhibitors that inhibit both the classical and alternative complement pathways. In particular, the invention relates to complement inhibitors derived from the salivary glands of haematophagous arthropods that inhibit both the classical and alternative complement pathways. The invention also relates to the use of such complement... Agent: Klauber & Jackson

20070141623 - Correction method for the distribution of quantity of light and biochip-reader: The present invention is characterized by the following points: In a biochip reader used for reading a measurement sample image by light beam irradiation, a correction method for the distribution of quantity of light which is devised to remove the influence of shading for the whole image and such a... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20070141571 - Diagnostics and therapeutics for diseases associated with endothelial differentiation, sphingolipid g-protein-coupled receptor 6(edg6): The invention provides a human EDG6 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders, urological disorders, thrombocytopenia and myeloma. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal... Agent: Banner & Witcoff, Ltd.

20070141591 - Dna binding protein-polymerase chimeras: The invention relates to compositions and methods directed to chimeric DNA polymerases, which comprise a mutated DNA binding polypeptide domain and a mutated or wild-type DNA polymerase polypeptide domain.... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070141619 - Drug resistance-associated gene and use thereof: The present invention relates to a protein which excretes cancer chemotherapeutic drugs from a cell and which confers drug-resistance on the cell, a DNA encoding the protein, a method for detecting a cell type resistant to cancer chemotherapeutic drugs, a method for screening an inhibitor to overcome the resistance to... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070141617 - Enveloped virus vaccine and method for production: The present invention provides methods of production of a purified enveloped virus antigen. In particular, it provides purified Ross River Virus (RRV) antigens, and vaccines comprising purified, inactivated Ross River Virus (RRV) antigen.... Agent: Baxter Healthcare Corporation

20070141587 - Gene expression profiling in biopsied tumor tissues: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon... Agent: Heller Ehrman LLP

20070141588 - Gene expression profiling in biopsied tumor tissues: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon... Agent: Heller Ehrman LLP

20070141589 - Gene expression profiling in biopsied tumor tissues: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon... Agent: Heller Ehrman LLP

20070141618 - Genes expressed in breast cancer as prognostic and therapeutic targets: Methods are disclosed for, determining the endocrine responsiveness of breast carcinoma and treating and monitoring the progression of breast carcinoma based on genes which are differentially expressed in breast tumors. Also disclosed are methods for identifying agents useful in the treatment of breast carcinoma, methods for monitoring the efficacy of... Agent: Novartis Corporate Intellectual Property

20070141614 - Genetic process for multiplex terminal restriction fragment length polymorphism analysis: There is provided a method of nucleic acid analysis which allows analysis of genetic diversity in multiple populations to be performed rapidly and simultaneously. The method comprises (a) isolating nucleic acid from said sample; (b) providing at least two pairs of labelled primers, wherein each said primer pair is complementary... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070141578 - Luxo-sigma54 interactions and methods of use: The invention relates to the identification and isolation of a novel sigma 54 (σ54) transcription factor from Vibrio harveyi. The invention further relates to the identification of σ54 interactions with LuxO. More particularly, the invention provides methods for identifying compounds that regulate bacterial cell growth and virulence by regulating LuxO-σ54... Agent: Mathews, Shepherd, Mckay, & Bruneau, P.A.

20070141603 - Mammalian tnf-alpha convertases: The present invention provides isolated human and bovine TNF-α convertases, nucleic acids and; recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods for making the convertases using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070141600 - Me-5, me-2, and epp2: human protein antigens reactive with autoantibodies present in the serum of women suffering from endometriosis: Three human endometrial antigens, ME-5, ME-2 and EPP2, and combination thereof have been discovered that are the targets of antibodies present in the serum of women suffering from endometriosis. These protein products and the human antibodies reactive with them are used as tools for diagnostic assays that monitor patients with... Agent: Joseph E. Mueth, Esq. Joseph E. Mueth Law Corporation

20070141581 - Membrane androgen receptor as a therapeutic target for the prevention/promotion of cell death: The present invention includes compositions, kits and methods for specifically and differentially activating a membrane androgen receptor and their use for comparing the binding specificity of one or more drugs to a membrane androgen receptor and to an intracellular androgen receptor, wherein a difference in drug binding is indicative of... Agent: Chalker Flores, LLP

20070141577 - Method: A method of screening for genetic or epigenetic markers associated with autism or related disorders comprises the steps of providing a biological sample from a mammal; and testing the sample or genetic material isolated from the sample for genetic polymorphisms/mutations and/or epigenetic alterations. The polymorphism may be located in the... Agent: Jacobson Holman Professional Limited Liability Company

20070141582 - Method and kit for detection of early cancer or pre-cancer using blood and body fluids: This invention is related to a method for the detection of early or pre-cancer using DNA isolated from blood and body fluids. This invention provides an improved methylation-based PCR assay, a panel of methylated-based cancer-related gene markers for the detection of general cancer and a panel of demethylation-based tissue- or... Agent: Jessica M. Li

20070141575 - Method and kit for primer based multiplex amplification of nucleic acids: Disclosed is a novel method for diagnosis or differential diagnosis of disease agents and secondary disease agents. The method disclosed uses a novel amplification strategy termed TemPCR to allow sensitive and specific amplification of target sequences from any disease agents and/or secondary disease agent whose nucleic acid sequence is known.... Agent: Bradley Arant Rose & White, LLP Intellectual Property Department-nwj

20070141595 - Method for assaying reg iv mrna: In an RNA amplification process comprising steps of using a first primer and a second primer, at least one of which has a promoter sequence at the 5′ end, and reverse transcriptase, to produce double-stranded DNA containing the promoter sequence, using the double-stranded DNA as template to produce an RNA... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070141615 - Method for attachment of silylated molecules to glass surfaces: A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070141568 - Method for determining the presence of one or more ligands in a sample: The present invention relates to a method for determining the presence of one or more specific ligands in a sample, said method comprising: a) contacting the sample with an array of cell lines, each cell line comprising a reporter gene construct responding to a cellular pathway which is induced by... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070141574 - Method for identifying a biosynthetic pathway gene product: The present invention provides isolated, genetically modified host cells, where a host cell is genetically modified with a nucleic acid that includes a nucleotide sequence encoding a biosynthetic pathway enzyme. Synthesis of the enzyme in the host cell results in conversion of a substrate for the enzyme into a biosynthetic... Agent: Bozicevic, Field & Francis LLP

20070141594 - Method of producing short hairpin library: Described herein is a method of cloning synthetic oligos (including in situ synthesized oligos) into an (one or more) expression vector for library (e.g., shRNA library) production. The oligos are synthesized with one portion of the first stem of the hairpin, followed by a first loop sequence, the complete second... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070141621 - Method of screening for sensitivity to kinase inhibitor therapy: Described herein are methods for treating cancer and other disease conditions in individuals who have either developed a resistance to conventional tyrosine kinase inhibitor (TKI) therapy or who are non-responsive ab initio to conventional TKI therapy. In various embodiments, the methods include administering to a patient a resistance-surmounting quantity of... Agent: Davis Wright Tremaine LLP

20070141604 - Method of target enrichment: The present invention is directed to a method for reducing the complexity of a nucleic acid sample in a reproducible manner by enriching for specific nucleic acid target sequences in the population of nucleic acids. More specifically, the invention relates to a method for enriching specific target sequences in a... Agent: Klauber & Jackson

20070141566 - Methods and materials relating to novel polypeptides and polynucleotides: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to the novel polynucleotides and polypeptides. Other aspects of the invention include vectors containing processes for producing novel polypeptides, and antibodies specific for such polypeptides.... Agent: Nuvelo, Inc

20070141599 - Methods and systems for molecular fingerprinting: This invention relates in general to a method for molecular fingerprinting. The method can be used for forensic identification (e.g. DNA fingerprinting, especially by VNTR), bacterial typing, and human/animal pathogen diagnosis. More particularly, molecules such as polynucleotides (e.g. DNA) can be assessed or sorted by size in a microfabricated device... Agent: Townsend And Townsend And Crew, LLP

20070141610 - Methods, compositions, and kits for forming self-complementary polynucleotides: The present teachings generally relate to methods, kits, and compositions for detecting target polynucleotide sequences. The teachings also relate to ligation and amplification reactions that generate self-complementary polynucleotide products. In some embodiments, ligation reactions are performed with probes that result in the formation a self-complementary ligation product. Ligation of a... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070141616 - Microreactor: wherein X1 represents —CR1═CR2R3 or —CHR1—CR2R3Y; R1, R2 and R3 independently represent an atom or a group selected from the group consisting of a hydrogen atom, a C1-6 alkyl group, a C6-20 aryl group, and a C7-20 aralkyl group having a C1-6 alkyl chain; Y represents a group which can... Agent: Sughrue Mion, PLLC

20070141590 - Modulators of tissue regeneration: Proteins which are upregulated in injured or regenerating tissues, as well as the DNA encoding these proteins, are disclosed, as well as therapeutic compositions and methods of treatment encompassing these compounds.... Agent: Fish & Richardson PC

20070141579 - Mum-1 protein expressed by multiple myeloma-related gene: This invention provides a method of determining a chromosomal breakpoint in a subject suffering from multiple myeloma which comprises steps of: (a) obtaining a DNA sample from the subject suffering from multiple myeloma; (b) determining whether there is J and C disjunction in the immunoglobulin heavy chain gene in the... Agent: Cooper & Dunham, LLP

20070141606 - Novel chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070141607 - Novel chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070141598 - Nucleotide compositions and uses thereof: The present invention relates to preparation of nucleotide compositions and uses thereof for conducting nucleic acid analyses. The compositions and methods embodied in the present invention are particularly useful for nucleic acid analyses that require high-resolution detection of labeled nucleotides or labeled nucleic acid targets.... Agent: Morgan, Lewis & Bockius LLP (sf)

20070141613 - Parametric imaging of gene expression in biopsy samples utilizing the reverse transcriptase-polymerase chain reaction method: A method is described for generating and showing the profile of one or more genes across a tissue sample. Tissue removed from the body is sliced in to thin sheets and those sheets are then divided into small portions each portion being identified as to a location in the sheet.... Agent: Koppel, Patrick & Heybl

20070141580 - Plasma deposited microporous analyte detection layer: Plasma deposited microporous analyte detection layers, method of forming analyte detection layers, and analyte sensors including the same are disclosed. An analyte sensor includes a substrate and a microporous amorphous random covalent network layer. The microporous amorphous random covalent network layer includes silicon, carbon, hydrogen and oxygen with a mean... Agent: 3m Innovative Properties Company

20070141596 - Plate, determination kit, and determination method for immunoassay: Disclosed herein are a plate capable of determining the presence or absence of an anti-virus antibody with higher accuracy, a determination kit equipped with the plate, and a determination method using the determination kit for immunoassay. The determination method is as follows. First, a liquid specimen is fed into each... Agent: Greenblum & Bernstein, P.L.C

20070141572 - Polynucleotides for the detection of listeria moncytogenes: Polynucleotide primers and probes for the amplification and detection of Listeria monocytogenes in samples are provided. The primers and probes can be used in real time diagnostic assays for rapid detection of Listeria monocytogenes in a variety of situations. Kits comprising the primers and probes are also provided.... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070141620 - Polyol-ifn-beta conjugate and composition containing same: PEG-IFN-β conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-β, are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070141605 - Portable preparation, analysis, and detection apparatus for nucleic acid processing: The present teachings comprise a device and method for lysing and/or purifying biological sample. The device can comprise a cartridge having a chamber containing a biological sample receiving region, a plurality of electrodes, and one or more sieving matrices. The electrodes can be configured to lyse the biological sample through... Agent: Kilyk & Bowersox, P.l.l.c.

20070141609 - Screening and therapy for lymphatic disorders involving the flt4 receptor tyrosine kinase (vegfr-3): The present invention provides materials and methods for screening for and treating hereditary lymphedema in human subjects.... Agent: Marshall, Gerstein & Borun LLP

20070141602 - Sirna targeting aquaporin 4: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.... Agent: Kalow & Springut LLP

20070141601 - Sirna targeting camp-specific phosphodiesterase 4d: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.... Agent: Kalow & Springut LLP

20070141611 - Sirna targeting spleen tyrosine kinase: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes.... Agent: Kalow & Springut LLP

20070141569 - Splice variant of human placental growth hormone: This invention relates to a protein, termed INSP105, herein identified as a splice variant of human placental growth hormone and to the use of this protein and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070141612 - Systematic in silico selection method for identifying drug targets in pathogens: Methods and compositions are provided for selecting drug targets in silico, that include the following steps performed in the order presented or an alternative order of partially or entirely at the same time: (a) identifying one or more essential or functionally important sequences from a model organism using pre-existing genomic... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20070141592 - Thermostable reverse transcriptases and uses thereof: The present invention is in the fields of molecular and cellular biology. The invention is generally related to reverse transcriptase enzymes and methods for the reverse transcription of nucleic acid molecules, especially messenger RNA molecules. Specifically, the invention relates to reverse transcriptase enzymes which have been mutated or modified to... Agent: Invitrogen Corporation C/o Intellevate

20070141567 - Waveguide system for detection of fluorescently labeled nucleic acid sequences: A system for detecting and identifying fluorescently labeled nucleic acid sequences. An embodiment of the system is comprised of an optical waveguide, an excitation light, a photo detector, filters for select fluorescent emissions, a reaction chamber, a data interpretation algorithm, and an addressable array, which assigns a known nucleic acid... Agent: Gray, Plant, Mooty, Mooty & Bennett, P.A.

20070141624 - Activity-based probes and methods of their preparation ans use: The present invention provides compositions and methods for assessing profiles of catalytically active enzymes in compositions containing a plurality of proteins. In preferred embodiments, the enzyme is a hydrolase, most preferably a cysteine protease. The methods described herein use activity based probes (“ABPs”) that have an affinity moiety for directing... Agent: Foley & Lardner LLP

20070141630 - Identification of non-covalent complexes by mass spectrometry: Methods for identifying novel drug leads or binding compounds that have an affinity for a target molecule involving screening known drug fragment molecules and derivatives thereof, preferably using mass spectrometry are disclosed.... Agent: Genentech, Inc.

20070141626 - Immunoassay for venom detection including noninvasive sample collection: Methods and immunoassays for diagnosing a bite or sting of a venomous organism in a patient having symptoms consistent with such a bite or sting are provided. A sample of venom is collected from the area of the suspected bite or sting using a swab and then contacted with an... Agent: Greenlee Winner And Sullivan P C

20070141625 - Method for assessing risk of and predisposition to development of a pathology related to the presence of anti-epcr autoantibodies: The present invention relates to a method for detecting the presence of high levels of autoantibodies against protein C/activated protein C endothelial receptor (EPCR). The invention is characterised in that it comprises in vitro detection and quantification of anti-EPCR autoantibodies in a sample.... Agent: Moore & Van Allen PLLC

20070141631 - Methods for testing for and inhibiting the development of huntington's disease: This invention relates to Huntington's disease and more specifically to methods for testing and inhibiting the development of Huntington's disease.... Agent: Antoinette G. Giugliano, P.C.

20070141629 - Nylon binding peptides and methods of use: Combinatorially generated peptides are provided that have binding affinity for nylon (NY). The peptides may be used to deliver benefit agents to various NY surfaces.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070141628 - Polyethylene binding peptides and methods of use: Combinatorially generated peptides are provided that have binding affinity for polyethylene (PE). The peptides may be used to deliver benefit agents to various PE surfaces.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070141627 - Systemic lupus erythematosus: This document relates to methods and materials involved in diagnosing SLE. For example, this document provides arrays for detecting polypeptides that can be used to diagnose SLE in a mammal. In addition, methods and materials for assessing SLE activity, determining the likelihood of experiencing active SLE, and detecting SLE treatment... Agent: Fish & Richardson P.C.

20070141634 - Assay: An in vitro method of determining activation or inactivation of the atrial natriuretic peptide (ANP) and brain natriuretic peptide (B3NP) hormonal systems, the method comprising simultaneously detecting the presence or amount of atrial and brain natriuretic peptide prohormones (proANP and proBNP) or fragments thereof in a sample.... Agent: Clark & Elbing LLP

20070141638 - Bgt1 transporters expressed in blood brain barrier cells: BGT1 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the BGT1 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in... Agent: Townsend And Townsend And Crew, LLP

20070141641 - Compositions & methods for reformulating biological membranes for arrays: A standardized, buffered solution or “ink” composition for re-formulating or suspending biological membranes used in the fabrication of membrane arrays. The composition can enhance assay performance and prolong the shelf life of biological membrane arrays. The ink composition comprises a combination of at least two of the following six classes... Agent: Corning Incorporated

20070141633 - Diagnostic kit for liver cirrhosis comprising an antibody specific for human protooncogenic protein: Provided are a method for detecting liver cirrhosis by measuring the level of expression of HCCR-2 protein in a specimen sample in vivo by an antigen-antibody binding reaction using an antibody specifically binding to a protein expressed from human proto-oncogene HCCR-2, and a kit for diagnosing liver cirrhosis using the... Agent: Jones Day

20070141632 - Function and regulation of angiopoietin-3/angiopoietin-4: The present invention relates to Angiopoietin-3 (Ang-3) and Angiopoietin-4 (Ang-4). The present invention also relates to methods of modulating an activity of Ang-3 or Ang-4. The present invention further relates to methods of treating cancer, diabetes, and arthritis.... Agent: Pepper Hamilton LLP

20070141642 - Guanosine triphosphate (gtp)-binding protein-coupled receptor protein, bg37: The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene “BG37”. cDNA containing the ORF of the gene was cloned and its nucleotide sequence was determined. Moreover, novel GPCR “BG37” genes from mouse... Agent: Knobbe Martens Olson & Bear LLP

20070141637 - Marker for fenestrae: The invention relates to a plasma membrane marker for identifying fenestrae. The invention also relates to a method of visualizing fenestrae utilizing a plasma membrane marker and light microscopy. The invention also relates to a method of identifying a plasma membrane marker for fenestrae. In particular, the invention relates to... Agent: (osi) Eyetech, Inc.

20070141636 - Method for identifying androgen receptor modulators with full or mixed agonist activity: A method for identifying androgen receptor (AR) modulators which have full AR agonist or antagonist activity or mixed AR agonist activity is described. In one aspect of the invention, an analyte with mixed AR agonist activity is identified by comparing binding of the analyte to a human AR to its... Agent: Merck And Co., Inc

20070141635 - Novel translocation assay: The present invention relates to a novel in vitro assay for determining the level of a protein, in particular, a membrane transport protein that is located at the plasma membrane of a cell compared to the level of the protein in the cell. The process of the invention is also... Agent: Knobbe Martens Olson & Bear LLP

20070141639 - Octn2 transporters expressed in blood brain barrier cells: OCTN2 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the OCTN2 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in... Agent: Townsend And Townsend And Crew, LLP

20070141640 - Screen for sodium channel modulators: A method or screen for assessing the potential of a compound to treat a pathological condition, such as arrhythmia, which is manifested by an increased late sodium current in a heart is disclosed. The method employs a mutant sodium channel protein having an amino acid sequence in which one or... Agent: Heslin Rothenberg Farley & Mesiti PC

20070141647 - Hybrid bio actuator and method of manufacturing the same using 3-dimensional micro molding aligner: A hybrid bio actuator and a manufacturing method thereof using a 3-dimensional micro molding aligning apparatus are provided. The manufacturing method has the steps of: 3-dimensionally forming an actuator body with polymer using the micro molding aligning apparatus; and transplanting and cultivating the muscular cell onto the actuator body. The... Agent: Mcdermott Will & Emery LLP

20070141646 - Preparation of red blood cells with a modified level of blood group antigen expression and their use in the quality control of blood typing reagents: A method for the preparation of red blood cells expressing reduced levels of blood group antigens using at least one immunodominant sugar modifying enzyme, for example alpha-N-acetylgalactosaminidase or alpha-galactosidase. The red blood cells produced preferably express a level of antigen substantially equivalent to the clinically significant threshold for the antigen.... Agent: Duane Morris LLP

20070141648 - Flj10607 as modifier of the axin pathway and methods of use: Human FLJ10607 genes are identified as modulators of the Axin pathway, and thus are therapeutic targets for disorders associated with defective Axin function. Methods for identifying modulators of Axin, comprising screening for agents that modulate the activity of FLJ10607 are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20070141652 - Isolation of the mitotic spindle matrix and its methods of use: The invention encompasses a purified preparation of the mitotic spindle matrix essential for mitotic spindle assembly, which allows for identifying an agent that modulates a cell division and/or differentiation signaling pathway comprising determining the effect of the agent on spindle formation, MT nucleation, or lamin matrix assembly wherein the change... Agent: Morgan Lewis & Bockius LLP

20070141649 - Loc169505 as modifiers of the apc and axin pathways and methods of use: Human LOC169505 genes are identified as modulators of the APC and axin pathways, and thus are therapeutic targets for disorders associated with defective APC and axin function. Methods for identifying modulators of APC and axin, comprising screening for agents that modulate the activity of LOC169505 are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20070141651 - Method for judging feature of malignant tumor: A method for judging feature of malignant tumor is described herein. The method comprises obtaining step, first comparing step, second comparing step, and judging step. The obtaining step comprises obtaining a first parameter based on activity and expression level of a first CDK contained in a tumor cell of the... Agent: Sughrue Mion, PLLC

20070141650 - Predicting cancer progression: The present invention involves early prediction of progression of a cancer disease in patients treated for cancer. According to the invention the binding response level of an immunoreactive material (IM) comprising thymidine kinase 1 (TK1) protein is determined in a body fluid sample of a patient and the likelihood of... Agent: Dinsmore & Shohl, LLP

20070141653 - Method for diagnosing infectious diseases: A method for diagnosing the presence in an animal of an infection due to a microorganism in which a test sample obtained from the animal is exposed to a population of the microorganism and the presence of binding of the microorganism by an antibody in the test sample is determined.... Agent: Howard Eisenberg, Esq.

20070141644 - Novel receptors: The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of the receptors.... Agent: Banner & Witcoff, Ltd.

20070141643 - Protease inhibitor conjugates and antibodies useful in immunoassay: Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal... Agent: Roche Diagnostics Operations Inc.

20070141645 - Measuring method using whole blood: A method for measuring an analyte in a whole blood sample comprising the steps of (1) bringing the whole blood sample into contact with a first substance which is carried on an insoluble carrier and specifically binds to the analyte to be measured and a second substance which is labeled... Agent: Heslin Rothenberg Farley & Mesiti PC

20070141654 - Elisa kit for diagnosing infectious bursal disease (ibd) and method using the same: The present invention relates to an ELISA kit for diagnosing infectious bursal disease (IBD). In particular, the present invention provides an indirect ELISA kit comprising recombinant VP2H or VP3 as the antigen for detecting anti-IBDV antibodies in serum samples. The present invention relates to a method for diagnosing infectious bursal... Agent: Pai Patent & Trademark Law Firm

20070141656 - Method for characterizing autoimmune disorders: The invention relates to methods of characterizing autoimmune diseases by detecting and measuring at least one analyte using multiplexed assay systems. According to one embodiment, a target is detected and measured by different bead sets having different reactants. According to another approach the ratio of self-antigen to autoantibody is measured... Agent: Daffer Mcdaniel LLP

20070141655 - Multi symptom medical test to diagnose causes of vaginitis: The present invention provides methods and apparatuses for a multi symptom test system. The multi symptom test apparatus having a plurality of zones for testing a plurality of conditions comprises the plurality of zones configured to receive a test sample wherein the zones responsive to the test sample provides a... Agent: Emil Chang Law Offices Of Emil Chang

20070141658 - Fluorogenic probes for reactive oxygen species: The present invention provides a novel class of fluorogenic probes for reactive oxygen species. Exemplary probes of the invention utilize a boronate deprotection mechanism to provide high selectivity and optical dynamic range for detecting H2O2 in aqueous solution over similar reactive oxygen species (ROS) including superoxide, nitric oxide, tert-butyl hydroperoxide,... Agent: Morgan, Lewis & Bockius LLP (sf)

20070141659 - Sets and compositions pertaining to analyte determination: This invention pertains to methods, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.... Agent: Applied Biosystems

20070141657 - Test system for the determination of in-vivo active hemostasis proteases or of trypsin or subtilisin in biological fluids and/or the usage thereof to determine the in-vivo activation of hemostasis or to diagnose pancreatitis: The present invention describes a test system for the determination of in-vivo active hemostasis proteases in biological fluids and the use thereof to determine the in-vivo activation of hemostasis or to diagnose pancreatitis.... Agent: Connolly Bove Lodge & Hutz LLP

20070141660 - Methods for producing end-products from carbon substrates: The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction... Agent: Genencor International, Inc. Attention: Legal Department

20070141661 - Cell extract for high-functioned cell-free protein synthesis and method of preparing the extract: The subjects of the present invention are to prepare a highly functionalized cell extract for cell-free protein synthesis and to specify and eliminate inhibitors and unstable substances present in conventional and various cell extracts for cell-free protein synthesis. Also provided is a method for preparing the cell extract for use... Agent: Jhk Law

20070141662 - Fusion proteins and methods of cleavage of such proteins: The invention provides a method of processing recombinant proteins by using aspartate specific proteases.... Agent: Novo Nordisk, Inc. Patent Department

20070141663 - Process for the preparation of copolymer-1: Copolymer-1 is a mixture of synthetic polypeptides composed of alanine, glutamic acid, lysine, and tyrosine. The invention relates to an improved process for the preparation of copolymer-1 characterized by the deblocking of the protected copolymer-1 that is carried out in one reaction. The process of the present invention has the... Agent: Cohen, Pontani, Lieberman & Pavane

20070141667 - Biopolymer based on lactococcus lactis nrrl b-60656, process for culturing lactocuccus lactis nrrl b-30656, and process for preparing the biopolymer: A microorganism isolated from soil was identified as being a Lactococcus lactis strain (NRRL B-30656) which produced an extracellular transferase enzyme when grown in a medium containing sucrose. This produced a glucose and fructose biopolymer on being purified and placed in a medium with sucrose in suitable temperature and pH... Agent: Birch Stewart Kolasch & Birch

20070141671 - Canine il-5 proteins and fragments thereof: The present invention relates to canine interleukin-5 proteins; canine interleukin-5 nucleic acid molecules, including those that encode canine interleukin-5 proteins; to antibodies raised against such proteins; and to inhibitory compounds that regulate such proteins. The present invention also includes methods to identify and obtain such proteins, nucleic acid molecules, antibodies,... Agent: Heska Corporation Intellectual Property Dept.

20070141665 - Chimeric protein for the screening of agonists and antagonists of cell signalling pathways that are dependent on g-protein-coupled receptors: The invention relates to a chimeric protein which is derived from a high-threshold calcium channel and which is characterised in that it consists of at least one β subunit or a fragment of same comprising at least the BID domain, which is fused at the NH2 or COOH end thereof... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070141668 - Cloned genome of infectious hepatitis c virus of genotype 2a and uses thereof: The present invention discloses nucleic acid sequence which encodes infectious hepatitis C virus of strain HC-J6CH, genotype 2a, and the use of the sequence, and polypeptides encoded by all or part of the sequence, in the development of vaccines and diagnostics for HCV and in the development of screening assays... Agent: Knobbe, Martens, Olson & Bear, LLP

20070141664 - Csnks as modifiers of the rac pathway and methods of use: Human CSNK genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of CSNK are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20070141674 - Host cells and culture methods: Improved host cells and culture methods involving overexpression of MAN1C1 activity to improve protein production are provided.... Agent: Marshall, Gerstein & Borun LLP

20070141666 - Leader sequences for use in production of proteins: This invention encompasses novel leader sequences for production of proteins. More specifically, the invention relates to DNA constructs encoding leader sequences comprising an immunoglobulin signal peptide fused to a tissue-type plasminogen activator propeptide, and to DNA constructs encoding leader sequences comprising a truncated human tissue-type plasminogen activator propeptide. The invention... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070141670 - Mammalian cytokine-like polypeptide-10: A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070141672 - Minimalist bzip proteins and uses thereof: The present invention provides minimalist bZIP proteins having a basic region derived from bHLH proteins fused to a leucine zipper dimerization domain derived from bZIP proteins and methods and uses thereof in the treatment of cancer. The present invention also provides pharmaceutical compositions for treating cancer.... Agent: Bereskin And Parr

20070141669 - Pregnancy-associated plasma protein-a2 (papp-a2): The present invention provides nucleotide and amino acid sequences that identify and encode a new protein with homology to pregnancy-associated plasma protein-A (PAPP-A). We denote this protein PAPP-A2. The cDNA encoding PAPP-A2 was derived from human placenta. The present invention also provides for antisense molecules to the nucleotide sequences which... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070141675 - Process for producing glycoprotein: A means of controlling sugar chain-modification and sugar chain structure in the production of a glycoprotein with the use of gene recombination techniques. A process for producing a glycoprotein by culturing a gene recombinant host in a medium characterized in that the relative sugar consumption speed is employed as an... Agent: Kilyk & Bowersox, P.l.l.c.

20070141673 - Tool for quantitative real-time analysis of viral gene expression dynamics in single living cells: The invention provides a method allowing the detection and the quantitative real-time measurement, at the single living cell level, of viral replication using a bioluminescent reporter gene and a digital light detection device sensitive to detect single photons with high efficiency and assign them a lateral x,y coordinate and precise... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070141676 - Cytokine protein family: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-α at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral... Agent: Zymogenetics, Inc. Intellectual Property Department

20070141677 - Genetic immunization with cationic lipids: A method for immunization using genetic material is disclosed. Compositions for genetic immunization comprising cationic lipids and polynucleotides are also disclosed. Methods for using genetic immunization to produce polyclonal and monoclonal antibodies are also disclosed. A method for epitope mapping is also disclosed.... Agent: Invitrogen Corporation C/o Intellevate

20070141679 - Methods and compositions for the treatment and prevention of hiv infection using trim5alpha: The invention provides novel TRIM polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length TRIM proteins, the invention further provides isolated TRIM fusion proteins, antigenic peptides and anti-TRIM antibodies. The invention also provides TRIM nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention,... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070141680 - Alleles of the mqo gene from coryneform bacteria: The invention relates to mutants and alleles of the coryneform bacterium mqo gene which encodes malate quinone oxidoreductases which contain any amino acid apart from L-serine at position 111, or a comparable position, in the amino acid sequence, and to processes for fermentatively preparing amino acids, preferably L-lysine, L-tryptophan and... Agent: Law Office Of Michael A. Sanzo, LLC

20070141681 - Process for the production of l-amino acids using strains of the enterobacteriaceae family: The present invention relates to a process for the production of L-amino acids by fermentation of recombinant microorganisms of the Enterobacteriaceae family, wherein a) the yfiD ORF and/or the pflB gene or nucleotide sequences coding for the gene products are overexpressed in the microorganisms producing the desired L-amino acid, and... Agent: Law Office Of Michael A. Sanzo, LLC

20070141682 - Microorganism producing 5'-xanthylic acid: The invention relates to a microorganism, obtained by treating Corynebacterium ammoniagenes KCCM 10488 producing 5′-Xanthylic acid as parent strain with UV radiation and mutation Derivatives such as N-methyl-N′nitro-N-nitrosoguanidine (NTG), Having a resistance to 5-fluorotryptophan which enhances Biosynthesis of N5-N10-tetrahydrofolate used for transferring Two formyl group during the process of puring... Agent: Birch Stewart Kolasch & Birch

20070141684 - Preparation of gamma-amino acids having affinity for the alpha-2-delta protein: e

20070141683 - Selective electrode for benzene and benzenoid compounds: An apparatus may be adaptable for laboratory, field, or in vivo detection and measurement of benzene, benzenoids, or other organic molecules or compounds. A selective binding agent is created by binding a target molecule or similar molecule with an appropriate monomer, polymerizing the monomer, and removing the target or similar... Agent: Pedersen & Company, PLLC

20070141685 - Feedback-resistant mevalonate kinases: The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing... Agent: Stephen M Haracz Bryan Cave

20070141686 - Process for cultivating microoraganisms of the genus thraustochytriales: The invention relates to an optimized method for the production of PUFAs by cultivating microorganisms belonging to the group of Stramenopiles in a fermentation medium that is pH-stabilized using calcium carbonate and comprises 3-15 g/L CaCO3, whereupon the PUFAs are isolated from the microorganisms and/or the medium. The invention particularly... Agent: Scott E Hanf Hammer & Hanf

20070141687 - Increase in stress tolerance with ascorbic acid during fermentation: A method of increasing stress tolerance in recombinant organisms that have been engineered for industrial production is described. Stress tolerance is increased by making L-ascorbic acid available to the recombinant organism, either by exogenous addition to the culture medium or by endogenous production from D-glucose by the recombinant organism. To... Agent: Ratnerprestia

20070141691 - Process for producing ethanol and for energy recovery: The present invention is directed to a process for the production of ethanol and energy. The process includes the steps of fermenting a corn mash in an aqueous medium to produce a beer. Next, the beer is distilled to produce ethanol and a whole stillage. The whole stillage is anaerobically... Agent: James P. Hanrath

20070141689 - Liquefaction process: The present invention relates to method of liquefying starch-containing material, wherein the method comprises the steps of (a) treating the starch-containing material with a bacterial alpha-amylase at a temperature around 70-90° C. for 15-90 minutes, and (b) treating the material obtained in step (a) with an alpha-amylase at a temperature... Agent: Novozymes North America, Inc.

20070141688 - Liquefaction processes: The present invention provides a process of liquefying starch-containing material comprising the step of treating said starch-containing material with at least one alpha-amylase and a maltogenic amylase or at least one amylase and at least one esterase.... Agent: Novozymes North America, Inc.

20070141690 - Mutant saccharomyces cerevisiae strain utilizing xylose for ethanol production: The present invention relates to a new xylose utilizing Saccharomyces cerevisiae strain being able to utilize xylose for ethanol production which strain is up-regulated with regard to the genes for xylose reductase (XR) and xylulose dehydrogenase (XDH) as well as xululokinase (XK) and over-expressing the non-oxidative pentose phosphate pathway (PPP)... Agent: Gauthier & Connors, LLP

20070141692 - Lipase powder composition and a process for preparing an esterified compound by using the same: There is provided a lipase composition comprising (a) a powdered lipase which is a lipase derived from Rhizomucor sp. or a powdered lipase which is a lipase derived from Penicillum sp. and (b) a powdered lipase selected from the group consisting of a powdered lipase which is a lipase derived... Agent: Buchanan, Ingersoll & Rooney PC

20070141693 - Polypeptide: The invention provides for a PS4 variant polypeptide derivable from a parent polypeptide having amylase activity which may be selected from the group consisting of: (a) a polypeptide comprising an amino acid mutation at each of positions 33, 34, 121, 134, 141, 146, 157, 161, 178, 179, 223, 229, 272,... Agent: Frommer Lawrence & Haug

20070141694 - Sequestering of glycoprotein molecules and oligosaccharide moieties in lipo-glycoprotein membranes and micelles: Spontaneous formation of a coherent membrane at the interface between a non-polar liquid and an aqueous solution of glycoprotein can be used to separate proteins and carbohydrates from tissue fluid and other complex mixtures. When volatile hydrocarbons are used to induce membrane formation, evaporation of organic and aqueous solvents leaves... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070141696 - Diagnostic test reader with locking mechanism: A diagnostic test reader includes an assay interface, a locking mechanism, and a test unit. The assay interface is configured to receive a diagnostic assay. The locking mechanism is configured to lock the diagnostic assay within the assay interface in response to one of the diagnostic assay and the diagnostic... Agent: Agilent Technologies Inc.

20070141695 - Luminescent dissolved oxygen sensor with visual verification: A method and apparatus for visually detecting when a luminescent dissolved oxygen sensor is operating is disclosed. In one example embodiment of the invention, a shutter is placed into the light tight container. When the shutter is open, a user can see into the light tight container and verify probe... Agent: The Ollila Law Group LLC

20070141697 - Method for producing cell culture substrate and apparatus for producing cell culture substrate: A method for producing a cell culture substrate to which cells adhere in a finely processed pattern while retaining the pattern for a long period of time to culture the cells and a production apparatus used in the production method. The method includes: forming a patterning substrate by forming: on... Agent: Ladas & Parry LLP

20070141698 - Microbial protein expression system utilizing plant viral coat protein: The present invention relates to an efficient microbial protein production system. A target protein is expressed as a portion of a fusion protein with the coat protein of Cymbidium mosaic virus (CyMV) in E. coli. Accordingly, the present invention provides nucleic acid expression vectors comprising a sequence encoding a protein... Agent: Akin Gump Strauss Hauer & Feld L.L.P.

20070141699 - Signal for packaging of influenza virus vectors: The invention provides a packaging (incorporation) signal for influenza virus vectors, and methods of using the signal to transmit and maintain influenza viral and foreign nucleic acid in virus and cells.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20070141700 - In vitro expansion of postpartum-derived cells in roller bottles: Methods for the maximizing parameter of the in vitro growth and expansion of mammalian cells, specifically postpartum-derived cells in containers such as roller bottles is described. Methods of optimizing growth rate and cell yield in such culture systems are provided. The methods are particularly adapted for human postpartum-derived cells, such... Agent: Woodcock Washburn LLP

20070141701 - Hepatitis c virus ns2/3 assay: The present invention provides an assay for the detection of the NS2/3 cleavage products NS2 or NS3 in the presence of uncleaved NS2/3. Following self-cleavage of NS2/3 to generate NS2 and NS3 cleavage products, a sample is incubated with a ligand specific for the recognition of NS2 or NS3 cleavage... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20070141702 - Parthenogenic activation of human oocytes for the production of human embryonic stem cells: Methods of producing human stem cells are disclosed for parthenogenetically activating human oocytes by manipulation of O2 tension, including manipulation of Ca2+ under high O2 tension and contacting oocytes with serine threonine kinase inhibitors under low O2 tension, isolating inner cell masses (ICMs) from the activated oocytes, and culturing the... Agent: Dla Piper US LLP

20070141703 - Methods for producing blood products from pluripotent cells in cell culture: The present invention provides methods for in vitro production of clinically useful quantities of differentiated human blood cells. In various embodiments of the present invention, immortal pluripotent cells are used to produce differentiated blood cell populations using a cell production device. In a specific embodiment, the device is a sequential... Agent: Bozicevic, Field & Francis LLP

20070141704 - Cell fusions and methods of making and using the same: The invention is concerned with fusions of dendritic cells and antigen presenting cells. Also provided are methods of making and using these cell fusions, including methods of adoptive immunotherapy. The fusions according to the invention can also be used in methods for antigen discovery.... Agent: Ivor R. Elrifi Mintz, Levin, Cohn, Ferris,

20070141706 - Adenovirus packaging cell lines: Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus substantially free of RCA are also provided, wherein the adenovirus is grown in a cell line containing coding sequences for adenovirus E1A and E1B,... Agent: Dla Piper US LLP

20070141705 - Method for producing viral vectors: The present invention provides methods for producing viruses, whose propagation depends on the cleavage of viral protein by a protease, in a manner independent of the protease. The methods of the present invention for producing viruses comprise producing viruses in the presence of a modified viral protein in which the... Agent: Clark & Elbing LLP

20070141707 - Sponge toxins: The present invention relates to the use of sponge toxins, in particular polymeric 1,3-alkylpyridinium salts (poly-APS), for the reversible formation of membrane pores and a method for producing such pores.... Agent: Licata & Tyrrell P.C.

20070141708 - Circular dna molecule having a conditional origin of replication, process for their preparation and their use in gene therapy: A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterised in that the region allowing the replication thereof has an origin of replication with a functionality in a host cell that requires the presence of at least one specific protein foreign to... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

  
06/14/2007 > patent applications in patent subcategories. archive of inventions by patent app class

20070134646 - Hyaluronic acid oligosaccharide fractions and drugs containing the same: A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070134647 - Material for promoting the freezing of water or hydrous substance: A novel material having ice nucleation activity or activity to promote freezing is provided. The present invention related to a carrier upon which polypeptides are immobilized for promoting the freezing of water or a hydrous substance. That is a carrier upon which polypeptides having side chains for binding to water... Agent: Sughrue Mion, PLLC

20070134648 - Affinity-based enrichment of phosphorylated peptides and/or proteins: The invention relates to a substance comprising a solid carrier that is connected to a spacer by means of a linker, said spacer comprising at least two defined groups. Said substance is suitable for using as an affinity material for enriching and/or isolating phosphorylated peptides and/or proteins. The inventive substance... Agent: Seed Intellectual Property Law Group PLLC

20070134651 - Apparatus and method for measuring activity signals of biological samples: The present invention provides an apparatus for measuring activity signals of a biological sample comprising: a measurement chamber (A) storing a target liquid containing a biological sample; a porous insulating substrate (5) provided with a measurement electrode (1) on at least one side; and a conveying device (8) which conveys... Agent: Mcdermott Will & Emery LLP

20070134649 - Method for monitoring the presence of biofilmforming microorganisms in paper industry: The invention is directed to a method for detecting the presence of biofilm-forming microorganisms in a paper or board making process for determining the need of an anti-biofilm agent in the process. The method comprises the steps: (a) subjecting a sampler device in the process line for a period of... Agent: Birch Stewart Kolasch & Birch

20070134650 - Scleraxis: Methods and compositions for modulating collagen synthesis are described.... Agent: Bereskin And Parr

20070134653 - Methods for treating lentivirus infections: The present invention provides methods of identifying an agent that inhibits an activity of a lentiviral Vif protein. The present invention provides methods of identifying an agent that increases the level of active APOBEC3G in a cell. The present invention provides agents identified by a subject screening method; and further... Agent: Townsend And Townsend And Crew, LLP

20070134652 - Multiplexed quantitative detection of pathogens: The invention allows for the quantitative detection of a plurality of pathogens in a single sample. The method includes the amplification of a sample with a plurality of pathogen-specific primer pairs to generate amplicons of distinct sizes from each of the pathogen specific primer pairs. The method further includes the... Agent: Edwards Angell Palmer & Dodge LLP

20070134675 - Alterations in the copy number of the sult1a1 gene: Methods are described for determining sulfonator status of a patient and determining dosages of drugs based on copy number of the SULT1A1 gene.... Agent: Fish & Richardson P.C.

20070134655 - Bioinformatically detectable group of novel regulatory genes and uses thereof: The present invention relates to a first group of novel genes, here identified as genomic address messenger or GAM genes, and a second group of novel operon-like genes, here identified as genomic record or GR genes. GAM genes selectively inhibit translation of known ‘target’ genes, many of which are known... Agent: Rosetta-genomics C/o Psws

20070134681 - Bladder cancer biomarkers and uses thereof: The invention relates to the identification and selection of novel biomarkers and the identification and selection of novel biomarker combinations which are differentially expressed in individuals with bladder cancer as compared with individuals without bladder cancer. Polynucleotides and proteins which specifically and/or selectively hybridize to the products of the biomarkers... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070134688 - Calculated index of genomic expression of estrogen receptor (er) and er-related genes: The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present... Agent: Fulbright & Jaworski L.L.P.

20070134703 - Chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070134678 - Comparative genome hybridization of organelle genomes: A comparative genome hybridization method is provided. In certain embodiments, the method comprises: a) contacting a first array of surface-bound nucleic acid probes with: i) a first labeled population of target nucleic acids from a genome of an organelle of a first cell; and ii) a second labeled population of... Agent: Agilent Technologies Inc.

20070134682 - Compartmentalized self tagging: The present invention relates to the development of a novel method for the selection of nucleic acid processing and other enzymes. In particular the invention relates to a method for the selection of nucleic acid polymerases and other enzymes with desired properties based on the method of compartmentalized self-tagging.... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070134711 - Compositions of eleutherosides capable of modulating protein expresion: Vaccines containing adjuvant comprising eleutherosides and related compounds are shown to be useful for the prevention of viral infections, bacterial infections and parasitic infections. The adjuvant compounds have been shown to modulate the expression of a wide variety or proteins involved in the immune response and inflammatory response. Exemplary eleutherosides... Agent: Bradley Arant Rose & White, LLP Intellectual Property Department-nwj

20070134685 - Control of chemical modification: Provided is a method for controlling the degree of labeling (DOL) of a carrier molecule or solid support by the addition of a reactive label competitor to the labeling reaction. When the reactive label competitor is added to the labeling solution the competitor competes with the carrier molecule or solid... Agent: Invitrogen Corporation C/o Intellevate

20070134695 - Dengue virus detection measured by immunocytometry in a dendritic cell surrogate: The invention concerns a method for diagnosing dengue invention early after dengue virus infection. The method comprises binding dengue virus contained in sera from infected patients with dentritic cell-specific intracellular adhesion molecule (ICAM) 3-grabbing nonintegrin (DC-SIGN) or liver/lymph node-specific intracellular adhesion molecule (ICAM) 3-grabbing nonintegrin (L-SIGN). DC-SIGN or L-SIGN can... Agent: Naval Medical Research Center Attn: (code 00l)

20070134710 - Device and method for multiple analyte detection: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample.... Agent: Kilyk & Bowersox, P.l.l.c.

20070134672 - Diagnosis method and kits for inherited neuropathies caused by duplication or deletion of chromosome 17p11.2-p12 region: Disclosed herein are a method and kit for diagnosing hereditary diseases CMT1A and HNPP, caused by duplication and deletion in the chromosome 17p11.2-p12 region. In accordance with the present invention, there is provided a method for diagnosing an inherited neuropathy, comprising, running the PCR amplification using microsatellites present in a... Agent: William Collard Collard & Roe, P.C.

20070134690 - Diagnosis of systemic onset juvenile idiopathic arthritis through blood leukocyte microarray analysis: The present invention includes compositions, systems and methods for the early detection and consistent determination of systemic onset juvenile idiopathic arthritis (SoJIA) using microarrays.... Agent: Chalker Flores, LLP

20070134708 - Diagnostic targets against johne's disease: A composition and method for detecting Mycobacterium infection are disclosed. The gcpE, pstA, kdpC, papA2, impA, umaA1, fabG2132, aceAB, mbtH2, lpqP, map0834c, cspB, lipN, and map 1634 genes of M. paratuberculosis are novel virulence determinants for Johne's disease. Eighteen M. paratuberculosis-specific genomic islands were identified. Twenty-four M. avium-specific genomic islands... Agent: Brinks Hofer Gilson & Lione

20070134696 - Dispersion of carbon nanotubes by nucleic acids: Nucleic acid molecules in a stabilized solution such as single stranded DNA and RNA were able to disperse high concentration of bundled carbon nanotubes into aqueous solution.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070134661 - Dna chip based genetic typing: This invention relates generally to the field of nucleic acid analysis. In particular, the invention provides a method for typing a target gene, using, inter alia, a chip comprising a support suitable for use in nucleic acid hybridization having immobilized thereon an oligonucleotide probe complementary to said target nucleotide sequence... Agent: Morrison & Foerster LLP

20070134687 - Focused microarray and methods of diagnosing cancer: Disclosed are methods for diagnosing cancer in a cell sample by detecting an increase in the levels of expression of marker genes in the cell sample as compared to the levels of expression of the same marker genes in a normal, nonneoplastic cell of the same tissue type. Also disclosed... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070134712 - Gene examining apparatus and method of detecting target nucleic acid using the same: The present invention relates to a gene examining apparatus utilizing a computer, the apparatus comprising (1) DNA microarrays in each of which a large number of fine liquid accommodating sections are two-dimensionally arranged so that openings of the fine liquid accommodating sections are located on the same plane, in which... Agent: Scully, Scott, Murphy & Presser

20070134706 - Gene information display method and apparatus: A gene information display method and apparatus for displaying waveform data obtained by fluorescence analysis of a DNA fragment that is subjected to PCR amplification and electrophoresis, in such a manner as to allow an experimental error to be easily detected through visual inspection. The apparatus, which displays the result... Agent: Reed Smith LLP

20070134664 - Human autism susceptibility gene and uses thereof: The present invention discloses the identification of a human autism susceptibility gene, which can be used for the diagnosis, prevention and treatment of autism and related disorders, as well as for the screening of therapeutically active drugs. The invention more specifically discloses that the SLC6A7 gene on chromosome 5 and... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070134658 - Identification of fetal dna and fetal cell markers in maternal plasma or serum: The present invention relates to the identification of fetal specific nucleic acids and fetal cell markers in maternal plasma or serum. In particular, the present invention relates to methods which rely on the analysis of polymorphic alleles of a population to determine an allele which is possessed by the fetus... Agent: Faegre & Benson LLP Patent Docketing

20070134663 - Interaction inhibitors, method of detecting interaction inhibitor and kit detecting interaction inhibitor: The task is to provide protein interaction inhibitors and/or detection method for interaction inhibitors related to regulation of T cell activation and production of IL-2. The present invention provides inhibitors of interaction between PKC theta and KPNA1, and inhibitors of interaction between KPNA1 and NF-kappaB. Inhibitors of interaction is defined... Agent: Foley And Lardner LLP Suite 500

20070134677 - Light directed dna synthesis using inverse capping for error reduction: A prepared substrate upon which light directed DNA synthesis is to occur is exposed to light via an inverse mask pattern to deprotect inactive regions of the substrate where the synthesis is not intended to occur. The deprotected sites are then capped to disable permanently the inactive areas, thereby forming... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator

20070134680 - Lipid metabolism molecules: The invention provides human lipid metabolism molecules (LMM) and polynucleotides which identify and encode LMM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LMM.... Agent: Foley And Lardner LLP Suite 500

20070134654 - Means for use in treating diseases correlated with or caused by non-physiological levels of microtubule-associated pp2ac: The present invention relates to a method of preventing or treating a disease correlated with or caused by non-physiologically increased intracellular levels of the catalytic subunit of microtubule-associated protein phosphatase 2A (PP2Ac) comprising administering to a subject affected by said disease or in danger of developing said disease a pharmaceutically... Agent: Pillsbury Winthrop Shaw Pittman LLP

20070134705 - Method and apparatus for predicting regulation of multiple transcription factors: Provided are a method and apparatus for predicting a regulation of multiple transcription factors which can predict a regulation correlation between the multiple transcription factors and a target gene, wherein the regulation correlation is used in a method of manipulating a gene inside an actual cell. The method includes: separating... Agent: Mayer, Brown, Rowe & Maw LLP

20070134700 - Method and array for detection and identification of microorangisms present in a sample using the genomic regions coding for different trna synthetases: The present invention discloses a method to detect and identify microorganisms that are present in a sample, which comprises hybridizing total DNA isolated from the sample with DNA fragments from regions that codifies for tRNA-synthases, hereinafter ‘tRNA-synthases’, said fragments being selected due to their specificity for each taxon to be... Agent: Merchant & Gould PC

20070134701 - Method and markers for determining the genotype of horned/polled cattle: Provided herein are methods to discover and use single nucleotide polymorphisms (SNP) for determining the genotype of a horned/polled ruminant subject. The present invention further provides specific nucleic acid sequences, SNPs, and SNP patterns that can be used for determining the genotype of a horned/polled ruminant subject.... Agent: Dla Piper US LLP

20070134668 - Method for analysis by molecular hybridization of nucleic acids and kit for carrying out said method: The invention concerns a method of assaying by molecular hybridization to detect the presence of nucleic acids that includes a step of acquiring samples of biological material by a sampling device with abrasive sampling means capable of retaining biological material in the form of cells, and a kit for application... Agent: Knobbe Martens Olson & Bear LLP

20070134714 - Method for attachment of silylated molecules to glass surfaces: A method for the efficient immobilization of silylated molecules such as silylated oligonucleotides or proteins onto unmodified surfaces such as a glass surface is provided. Also provided are compounds, devices, and kits for modifying surfaces such as glass surfaces.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070134669 - Method for diagnosis/prognosis of breast cancer: The present invention relates to a method for diagnosis/prognosis of breast cancer including the following stages: A—the nuclear material is extracted from a biological specimen, B—at least one pair of amplification primers is used for obtaining amplicons of at least one target sequence of the nuclear material, C—at least one... Agent: Oliff & Berridge, PLC

20070134693 - Method for modulating the binding activity of a novel icam-3 binding receptor on sinusoidal endothelial cells in liver and lymph nodes: The invention relates to the use of a compound that binds to a C-type lectin on the surface of a sinusoid endothelial layer, in the preparation of a composition for modulating, in particular reducing, the immune response in animal, in particular a human or another mammal. The sinusoid endothelial layer... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070134679 - Method for separating nanoparticles with a controlled number of active groups: The present invention discloses a method for separating nanoparticles with a controlled number of active groups is disclosed. First, a plurality of nanoparticles are provided, wherein the surface of the nanoparticle comprises a plurality of first active groups. Next, a plurality of functional ligands are provided, wherein the functional ligand... Agent: Rosenberg, Klein & Lee

20070134694 - Method for the measurement of dengue virus binding inhibition: The invention concerns a method of detecting dengue infection by detecting anti-dengue neutralizing substances including anti-dengue antibody by measuring inhibition of dengue binding to dentritic cell-specific intracellular adhesion molecule (ICAM) 3-grabbing nonintegrin (DC-SIGN) or liver/lymph node-specific intracellular adhesion molecule (ICAM) 3-grabbing nonintegrin (L-SIGN). DC-SIGN or L-SIGN can be used expressed... Agent: Naval Medical Research Center Attn: (code 00l)

20070134674 - Method for the prognosis and/or diagnosis of a cancer: The present invention relates to a method for the prognosis and/or diagnosis of a cancer using a biological sample taken from a patient, according to which the expression of the twist gene is determined. The invention also relates to the use of at least one inhibitor of twist gene expression... Agent: Oliff & Berridge, PLC

20070134719 - Method of controlling pharmacokinetics of immunomodulatory compounds: The present invention relates to a method of administering a-interferon into the intradermal compartment of a subject's skin, whereby absorption in the dermis produces improved systemic pharmacokinetics compared to subcutaneous administration. The present invention provides an improved method of delivery in that it provides, among other benefits, rapid systemic distribution... Agent: Becton, Dickinson And Company Alston & Bird LLP

20070134665 - Method of in situ detection of proteins using aptamers: The present invention is a method for the detection and localization of proteins in situ. The method comprises contacting a peptide tag labelled protein with a nucleic acid aptamer that recognizes the peptide tag. The nucleic acid aptamer is functionalized such that is detectable by a variety of methods. The... Agent: Sim & Mcburney

20070134692 - Method, system and, computer software for efficient update of probe array annotation data: In one embodiment, a method of assigning transcripts to probe sets is described that comprises retrieving one or more data sets from one or more sources; generating one or more clusters using transcript data from the data sets; aligning one or more probe sequences to a representative sequence from one... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070134686 - Methods and compositions for detection of a target nucleic acid sequence utilizing a probe with a 3' flap: The invention provides compositions, kits and methods of generating a signal indicative of the presence of a target nucleic acid sequence in a sample by forming a cleavage structure. The cleavage structure is formed by incubating a sample containing a target nucleic acid with a downstream probe that forms a... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070134691 - Methods and compositions for determining whether a subject carries a gene mutation associated with hereditary hearing loss: Methods are provided for determining whether a subject carries a gene mutation associated with Hereditary Hearing Loss (HHL). In practicing the subject methods, an array comprising a plurality of HHL-associated gene mutation probes is contacted with a nucleic acid sample from the subject, and the presence of any resultant surface... Agent: Bozicevic, Field & Francis LLP

20070134676 - Methods and compositions for performing sample heterogeneity corrected comparative genomic hybridization (cgh): Methods and compositions for performing sample heterogeneity corrected comparative genomic hybridization (CGH) are provided. In the subject methods, an initial CGH result is processed to account for potential sample heterogeneity to obtain a sample-heterogeneity corrected CGH result. Also provided are methods for evaluating candidate surface-bound nucleic acids, e.g., candidate aCGH... Agent: Agilent Technologies Inc.

20070134657 - Methods and compositions relating to gradient exposed cells: The invention relates to methods and compositions for stimulating or inhibiting directed cell migration.... Agent: Edwards Angell Palmer & Dodge LLP

20070134713 - Methods and kits for detecting a target cell: The present invention concerns the identification of specific target cells in whole blood. The present invention discloses methods for detecting and optionally quantifying a target cell in untreated or substantially untreated whole blood. The present invention further discloses kits for detecting and optionally quantifying a target cell in untreated or... Agent: Perkins Coie LLP

20070134660 - Methods for identifying modulators of kinesin activity: In a first aspect, the invention provides methods for screening for modulators of a target protein, comprising the steps of contacting a target protein with a candidate agent and determining whether the candidate agent modulates the activity of the target protein, wherein the target protein comprises a sequence that has... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20070134673 - Methods for predicting the risk of diabetic nephropathy using genetic markers and arrays containing the same: Disclosed is a method for detecting a Chinese diabetic subject suffering from, at risk for developing, or suspected of suffering from a nephropathy. The method includes determining whether a sample from the subject has at least one polymorphic sequence selected from the group consisting of polymorphic sequences an I/D genotype... Agent: Knobbe Martens Olson & Bear LLP

20070134670 - Methods for prediction and prognosis of cancer, and monitoring cancer therapy: The present invention relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of stanniocalcin as a biomarker for VEGFR2 inhibitors.... Agent: Jeffrey M. Greenman

20070134667 - Molecular single electron transistor (mset) detector device: A molecular single electron transistor (MSET) detector device (14) is described that comprises at least one organic molecule (87) connecting a drain electrode (84) and a source electrode (82). In use, said at least one organic molecule (87) provides a quantum confinement region. At least one analyte receptor site (90,... Agent: Nixon & Vanderhye, PC

20070134699 - Nano-scale ligand arrays on substrates for particle beam instruments and related methods: Substrates and arrays that can be used for biological analysis with particle beam instruments are provided. In one embodiment, a substrate for an array is constructed and arranged to be used for imaging samples with a particle beam instrument such as a transmission electron microscope. The substrate can include one... Agent: Wolf Greenfield & Sacks, P.C.

20070134704 - Novel chromophores/fluorophores and methods for using the same: Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein. The subject proteins... Agent: Bozicevic, Field & Francis LLP

20070134671 - Oligonucleotides for detection of leishmaniasis and methods thereof: The present invention relates to a novel oligonucleotide primers having SEQ ID NO: 1, SEQ ID No: 2, SEQ ID NO: 3 and SEQ ID NO: 4 for amplification of the kinesin-related gene of Leishmania species. The invention also provides a method for detecting and differentiating visceral leishmaniasis (VL) and... Agent: Birch Stewart Kolasch & Birch

20070134717 - Oxaloacetate hydrolase deficient fungal host cells: The present invention relates to isolated nucleic acid sequences encoding polypeptides having oxaloacetate hydrolase activity. The invention also relates to nucleic acid constructs vectors, and host cells comprising the nucleic acid sequences as well as recombinant methods for producing the polypeptides.... Agent: Novozymes North America, Inc.

20070134659 - Polynucleotides for the detection of salmonella species: Polynucleotide primers and probes for the amplification and detection of Salmonella species in samples are provided. The primers and probes can be used in real time diagnostic assays for rapid detection of one or more Salmonella species in a variety of situations. Kits comprising the primers and probes are also... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070134702 - Probe set, probe immobilized carrier and gene examination method: A probe and a primer capable of collectively detecting microorganisms of the same species while differentiating microorganisms of other species with an object of classification by species of fungus. An oligonucleotide probe for detecting an infectious etiologic microorganism gene includes at least one base sequence selected from the base sequences... Agent: Fitzpatrick Cella Harper & Scinto

20070134683 - Probes and methods for identifying polycyclic aromatic hydrocarbon-degrading mycobacteria: A method for determining whether a microorganism is capable of biodegrading a contaminant can include the following: providing a first set of DNA molecules consisting of fragments of genomic DNA of a contaminant-degrading mycobacterium; contacting under hybridizing conditions, the first set of DNA molecules with a second set of DNA... Agent: Workman Nydegger (f/k/a Workman Nydegger & Seeley)

20070134656 - Product and method: The present invention relates to oligonucleotide probes, for use in assessing gene transcript levels in a cell, which may be used in analytical techniques, particularly diagnosis techniques and kits containing the same.... Agent: Sughrue Mion, PLLC

20070134707 - Scintillation proximity assay for measuring polymerase activity: The present invention provides for methods of assaying the activity of a polymerase enzyme by using a Scintillation Proximity Assay (SPA) without the need of primers modified with affinity tags. The methods of the present invention can be practiced with any number of RNA and DNA polymerase enzymes.... Agent: Roche Palo Alto LLC Patent Law Dept. M/s A2-250

20070134666 - Simultneous analytical method for oxidatively damaged guanine compound and concentration correcting substance thereof, and analyzer used for this analytical method: An object of the present invention is to provide a method of efficiently analyzing an oxidatively damaged guanine compound and a concentration correcting substance for this oxidatively damaged guanine compound, and an analyzer for implementing this method. The present invention provides an analytical method characterized by a step to purify... Agent: Day Pitney LLP

20070134698 - Sirna targeting histamine receptor h1: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.... Agent: Kalow & Springut LLP

20070134697 - Sirna targeting tie-2: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.... Agent: Kalow & Springut LLP

20070134662 - Structural interaction fingerprint: Disclosed is a method for representing and analyzing 3D target molecule-ligand intermolecular interactions. The method generates structural interaction fingerprints (SIFts) that convert three-dimensional structural interaction information into linear information strings that contains a plurality of information blocks; each of which in turn containing a plurality of information units. By assigning... Agent: Steptoe & Johnson LLP

20070134715 - Systematic evolution of ligands by exponential enrichment: blended selex: A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated to the peptide Gly-Arg-Gly-Asp-Thr-Pro (SEQ ID NO:1). This blended RNA ligand inhibits the biological activity of gpIIbIIIa with high specificity. Also described is... Agent: Swanson & Bratschun L.L.C.

20070134689 - Tumor marker for ovarian cancer diagnosis: The present invention relates to a tumor marker for diagnosis of ovarian cancer, which is selected from the group consisting of alectin-1, cathepsin B, MHC class I antigen, heat shock protein (HSP) 27, ubiquitin carboxy-termal esterase L1, cellular retinol-binding protein (CRBP), transthyretin, SH3 binding glutamate-rich protein, tubulin-specific chaperone A, RNA... Agent: Wpat, PC Intellectual Property Attorneys

20070134709 - Usages of mthfr gene polymorphisms in predicting homocysteine level, disease risk, and treatment effects and related methods and kit: This invention features our discovery on usages of Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphisms in predicting homocysteine (Hcy) level and/or incidence and prognosis of diseases associated with increased Hcy level in a subject, as well as predicting treatment effects of medicines in the category of Angiotension Converting Enzyme Inhibihor (ACEI) with... Agent: Xiping Xu

20070134684 - Use of adenine as a method for controlled immobilization of nucleic acids and their analogs on gold surfaces: The method provides for attaching nucleic acids to a surface at a controlled grafting density in a controlled conformation by contacting an immobilization solution of nucleic acids containing at least one block of adenine nucleotides to a surface for a sufficient period of time to allow attachment to the surface.... Agent: Naval Research Laboratory Associate Counsel (patents)

20070134718 - Use of interleukin-15: The invention relates to the use of IL-15 or active variants thereof and/or IL-15 activity enhancing compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of the immune system, such as manipulating viability and/or responsiveness of said memory cells. The IL-15 activity enhancing compound is for example... Agent: Knobbe Martens Olson & Bear LLP

20070134716 - Zero-mode metal clad waveguides for performing spectroscopy with confined effective observation volumes: The present invention is directed to a method and an apparatus for analysis of an analyte. The method involves providing a zero-mode waveguide which includes a cladding surrounding a core where the cladding is configured to preclude propagation of electromagnetic energy of a frequency less than a cutoff frequency longitudinally... Agent: Wilson Sonsini Goodrich & Rosati

20070134727 - Antibodies to cytokine receptor: Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention... Agent: Zymogenetics, Inc. Intellectual Property Department

20070134723 - Compositions and methods for detecting phosphomonoester: The invention provides a method of modifying a phosphomonoester moiety of a target compound. The method can include the steps of (a) providing a target compound having an electrophilic moiety and a phosphomonoester moiety; (b) contacting the target compound with a first carbodiimide compound under conditions for preferential addition of... Agent: Illumina, Inc.

20070134726 - Diagnostic assay for stroke: Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for stroke. The invention provides a diagnostic assay for either of these markers, preferably by ELISA using a anti-H-FABP or B-FABP antibody. Since H-FABP is also a marker for acute myocardial infarction (AMI), to distinguish stroke from AMI requires... Agent: Baker Botts L.L.P.

20070134720 - Method of detecting effect of controlling synoviolin activity: The present invention provides methods for evaluating the regulation on prolyl 4-hydroxylase activity. The present invention also provides screening methods using the evaluation methods. Furthermore, the present invention provides methods of screening for compounds that are useful for treating or preventing fibrosis or rheumatoid arthritis. The present invention relates to... Agent: Morrison & Foerster LLP

20070134725 - Method to predict risk of bph progression: A method to predict benign prostatic hyperplasia symptom progression, acute urinary retention, need for surgical intervention and/or prostate cancer development in patients is provided.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20070134729 - Novel antibacterial agents: This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved... Agent: Theravance, Inc.

20070134722 - Passive tagging of products: A method of tagging a manufactured product with a passive tag includes determining a unique combination of at least two axis ratios. Each axis ratio is an isotopic ratio for a same-species ratio of enriched noble gas isotopes. A gas having the determined unique combination of at least two axis... Agent: Dorsey & Whitney, LLP Intellectual Property Department

20070134724 - Phosphorylation of tau by abl: Methods of diagnosing a tauopathy and predicting whether a subject will develop a tauopathy are provided. Also provided are antibody preparations that specifically bind to tau phosphorylated at tyr394 and/or tyr310. Methods of inhibiting tau phosphorylation in a cell and methods of treating a subject having a tauopathy are additionally... Agent: Amster, Rothstein & Ebenstein LLP

20070134731 - Proteomics based method for toxicology testing: A toxicoproteomic method for developing immunoassays to determine if a toxicant or a disease causes damage to a specific organ is disclosed. The discovery phase of the method involves the administration of a toxicant to an animal which will cause damage to a specific organ of the animal, which damage... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20070134730 - Screening method, screening program and screening device: The invention provides a screening method for selecting a particular candidate molecule by using binding amount data between a target molecule and the candidate molecule, the data being obtained by supplying the candidate molecule of study to a measurement region composed of an immobilization membrane on which the target molecule... Agent: Sughrue Mion, PLLC

20070134721 - Sensor: This invention relates to a sensor suitable for detecting the presence of one or more analytes. The sensor comprises a substrate; a confinement structure disposed on the substrate, wherein the confinement structure comprises at least a first limiting structure defining a first interior space; a transducer proximal to the first... Agent: Bromberg & Sunstein LLP

20070134728 - Systems and methods for characterizing conditions and diseases associated with organ transplantation and organ health: The present invention relates to methods of diagnosing, predicting and monitoring conditions and disorders associated organ transplantation and organ health. In particular, the present invention relates to the diagnosis, prediction and monitoring of disorders, conditions, and organ status by detection of cytokines, cytokine-related compounds, and chemokines, particularly in urine. The... Agent: Medlen & Carroll, LLP

20070134737 - Fluorophore compounds and their use in biological systems: Fluorophore compounds and methods for their use are disclosed. The fluorophores contain a 2-dicyanomethylen-3-cyano-2,5-dihydrofuran (DCDHF) moiety and one or more donor groups conjugated to the 2-dicyanomethylen-3-cyano-2,5-dihydrofuran group. The donor groups can contain atoms with free electron pairs such as oxygen, sulfur, nitrogen, or phosphorous. The fluorophore compounds can be used... Agent: Howrey LLP

20070134732 - Lces as modifiers of the p53 pathway and methods of use: Human LCE genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of LCE are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20070134738 - Methods for detecting deficient cellular membrane tightly bound magnesium for disease diagnoses: This invention relates to methods for detecting the deficiency of magnesium tightly bound to cellular membranes, i.e., magnesium binding defect, which deficiency is associated with certain abnormal physiological states, e.g., salt-sensitive essential hypertension or Type 2 diabetes mellitus.... Agent: Stinson Morrison Hecker LLP Attn: Patent Group

20070134736 - Multi-functional and configurable assay: Novel magnetic assay methods and systems. According to a preferred embodiment, a chromatographic medium is provided that is designed to be contacted with a test solution having activated magnetic particles such that the solution flows bilaterally thereacross. A magnetic field, generated by a magnet or electromagnet, is selectively applied to... Agent: Stetina Brunda Garred & Brucker

20070134734 - Novel screening method of indicator substance: An object of the present invention is to provide a novel means for finding a passive substance to the action of a selected trigger protein in a target cell system. In particular, the present invention succeeded in establishing a novel method for screening an indicator substance by the steps of... Agent: Kilyk & Bowersox, P.l.l.c.

20070134733 - Raman signature probes and their use in the detection and imaging of molecular processes and structures: Disclosed are methods and materials for detecting and imaging molecular processes and structures. Methods included detecting and imaging by contacting targets with RSPs, irradiating the target, and collecting and analyzing the spectra produced by the RSPs.... Agent: Wilson Sonsini Goodrich & Rosati

20070134735 - Transcriptional regulation of the human beta3-adrenergic receptor gene: Regulatory elements responsible for tissue-specific transcriptional regulation of the human β3-adrenergic receptor (β3-AR) were identified. A region localized between −6.50 and −6.30 kb of the proximal promoter contained three sequences that act synergistically to achieve full transcriptional activity. One segment, termed segment A, contains an Sp1 binding site. Another of... Agent: Darby & Darby P.C.

20070134740 - Compositions and articles for detection of analytes exceeding a pre-set threshold: The present invention provides a bodily fluid-testing composition for the determination and quantification of a specific ion concentration exceeding a pre-set threshold in a tested fluid, in which an ion oppositely charged to the ion in the bodily fluid is used to compete with an indicator reagent in order to... Agent: Winston & Strawn LLP Patent Department

20070134741 - Methods and compositions for detecting trichomonas in a sample contacted with fixative: The present invention provides methods and compositions for detecting a Trichomonas antigen in a fixed sample and for diagnosing Trichomonas infection by detecting a Trichomonas antigen in a fixed sample.... Agent: Myers Bigel Sibley & Sajovec

20070134743 - Detection of secreted aspartyl proteases from candida species: Methods and devices for the detection of proteins secreted by the hyphal growth form of Candida species are disclosed. The disclosed devices may constitute a method for the diagnosis of acute or chronic infections, including candidiasis, caused by microorganisms of the species Candida, such as C. albicans, for example. The... Agent: Dority & Manning, P.A.

20070134742 - Diagnostic reagent for uterine adenocarcinoma and method of detecting adenocarcinoma cells: The present invention provides diagnostic reagent or reagent kit whereby the presence of adenocarcinoma cells can be detected in cells obtained from uterine cervix obtained for cytodiagnosis, in particular, the presence of adenocarcinoma can be specifically detected in distinction from squamous carcinoma cells; and methods of detecting adenocarcinoma cells. Adenocarcinoma... Agent: Sughrue Mion, PLLC

20070134744 - Epothilone resistant cell lines: Epothilone resistant cells lines are disclosed. The invention also discloses methods for identifying substances which are cytotoxic to epothilone resistant cells or which are chemosensitizers or analogs of epothilone. The invention further discloses methods for identifying epothilone resistant cells and for inhibiting the growth of epothilone resistant cells in vitro... Agent: Novartis Corporate Intellectual Property

20070134745 - Human cytokine receptor: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”... Agent: Zymogenetics, Inc. Intellectual Property Department

20070134739 - Microfluidic assays and microfluidic devices: The invention is a method for determining in the amount of an analyte (An) in a sample. The method comprises competitive immunoassays and enzymatic assays in which a soluble product (immune complex and enzymatic product, respectively) is formed. The product is subsequently measured in a measuring zone of a microchannel... Agent: Fulbright & Jaworski, LLP

20070134748 - Biochemical sensor and measuring device having channel structure for sample collection: A biochemical sensor 30 capable of detecting a prescribed target substance in a specimen in a short time period with high sensitivity and measuring the amount thereof has a surface 31 and a rear surface, and channels 32 formed from the surface 31 to the rear surface, allowing influx of... Agent: Nixon & Vanderhye, PC

20070134747 - Detection of secreted lipase proteins from candida species: Methods and devices for the detection of proteins secreted by the pathogenic growth form of Candida species are disclosed. The disclosed devices may constitute a method for the diagnosis of acute or chronic infections, including candidiasis, caused by microorganisms of the Candida species, such as C. albicans, for example. The... Agent: Dority & Manning, P.A.

20070134746 - Diagnostic method for disease by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor: The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding... Agent: Diehl Servilla LLC

20070134749 - Protein tyrosine kinase substrate lat and its use in the identification of (ant)agonists of the kinase: The invention generally relates to compositions and methods for identifying and testing tyrosine kinase signaling pathway agonists and antagonists, and more particularly, methods and compositions for screening compounds and identifying compounds that will modulate the interaction of protein tyrosine kinase substrates with their intracellular ligands, as well as between their... Agent: Edwards Angell Palmer & Dodge LLP (client Reference No. 47992)

20070134751 - Fluorescence spectroscopy in absorbing media: The invention relates to processes and devices for detecting an analyte in a sample by fluorescence measurement.... Agent: Baker & Daniels LLP / Roche

20070134750 - Glucose dehydrogenase: Disclosed is a modified glucose dehydrogenase having pyrroloquinoline quinone as a coenzyme, wherein one or more amino acid residues in a region of 186-206 amino acid of water-soluble PQQGDH derived from Acinetobacter calcoaceticus or in an equivalent region from other species are replaced with other amino acid residues. Also disclosed... Agent: Birch Stewart Kolasch & Birch

20070134752 - Smooth muscle myosin phosphatase associated kinase: The present invention relates to a novel smooth muscle myosin phosphate associated kinase and to methods of identifying compounds useful in treating smooth muscle disease using same.... Agent: Nixon & Vanderhye, PC

20070134753 - Assay for determining the activity of fatty acid amide hydrolase: The invention provides methods of assaying fatty acid amide hydrolase (FAAH) activity adaptable for high through-put screening. The methods provide for separating a labeled substrate from at least one labeled hydrolysis product, the separation facilitating the quantification. The invention also provides methods of identifying a compound to be tested as... Agent: Philip S. Johnson Johnson & Johnson

20070134756 - Method and system of verifying protein-protein interaction using text mining: Provided are a method and system for verifying a protein-protein interaction according to a text mining method. The method includes extracting protein-protein interaction information from protein-related documents searched for from a bio-information document database, according to a text mining method, mapping the protein-protein interaction information to corresponding ontology identifications, and... Agent: Mayer, Brown, Rowe & Maw LLP

20070134754 - Method of measuring glycated amine: The present invention aims to enable highly reliable measurement of a glycated amine. A fructosyl amino acid oxidase (FAOD) is added to a sample to remove a non-analyte glycated amine that is present in the sample and different from an analyte glycated amine. Thereafter, a protease is added to the... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20070134755 - Method of producing cell extract for cell-free protein synthesis: A cell extract for cell-free protein synthesis is produced by removing substances, which bind to an affinity support to be used in purification or interaction analysis, from a cell extract having protein synthetic activity. Then, a target protein is synthesized by using the cell extract for cell-free protein synthesis. The... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070134757 - Method for cleaving proteins: This, invention relates to a method for cleaving proteins or peptides at a specific site. According to the invention an amino acid sequence is constructed at a predetermined cleavage site and the protein or peptide is allowed to react with free metal ions in a buffer. The buffer further comprises... Agent: Birch Stewart Kolasch & Birch

20070134763 - Anti-virus therapy for respiratory diseases: The present invention provides the use of IFN-β, an agent that increases the expression of IFN-β, or a polynucleotide which is capable of expressing IFN-β or said agent for the manufacture of a medicament for the treatment of rhinovirus-induced exacerbation of a respiratory disease selected from asthma and chronic obstructive... Agent: Morrison & Foerster LLP

20070134764 - Endogenous and non-endogenous version of human g protein-coupled receptors: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown, and to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.... Agent: Bozicevic, Field & Francis LLP (aren) (arena Pharmaceuticals, Inc.)

20070134762 - Immunogenic peptide carrier conjugates and methods of producing same: The present invention is directed to methods of producing conjugates of peptide immunogens with protein/polypeptide carrier molecules, which are useful as immunogens, wherein peptide immunogens are conjugated to protein carriers via activated functional groups on amino acid residues of the carrier or of the optionally attached linker molecule, and wherein... Agent: Sughrue Mion, PLLC

20070134760 - Method for stable gene-amplification in a bacterial host cell: A bacterial host cell comprising at least two copies of an amplification unit in its genome, said amplification unit comprising: i) at least one copy of a gene of interest, and ii) an expressible conditionally essential gene, wherein the conditionally essential gene is either promoterless or transcribed from a heterologous... Agent: Novozymes North America, Inc.

20070134766 - Methods of assessing hiv integrase inhibitor therapy: The present invention relates to methods and products for the evaluation of HIV treatment. The methods are based on evaluating molecular events at the HIV integrase resulting in altered therapeutic efficacy of the investigated compounds. The methods rely on providing an integrase gene and evaluating either through genotyping or phenotyping... Agent: Philip S. Johnson Johnson & Johnson

20070134758 - Methods of inhibiting hiv-1 vpr activity and hiv-1 infectivity using atr or rad17 inhibitors: Methods are disclosed for inhibiting the activity of a viral protein R (Vpr), inhibiting HIV replication, and treating or preventing an HIV infection through the use of an inhibitor of ATR or Rad17. Newly discovered ATR or Rad17 inhibitors are disclosed for use in accordance with the present invention, as... Agent: Edwin V Merkel Nixon Peabody

20070134761 - Minimal dna sequence acting as a chromatin insulator and its use in protein expression: The invention relates to expression vectors comprising a DNA sequence of 146 bp capable of acting as chromatin insulator, to host cells containing such vectors, to a method of producing a desired polypeptide by using vectors containing said sequence and to the use of said DNA sequence.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070134759 - Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase: The present invention provides a process for producing an antibody composition using a cell, which comprises using a cell into which an RNA having activity of suppressing the function of an enzyme relating to the modification of a sugar chain in which 1-position of fucose is bound to 6-position of... Agent: Nixon & Vanderhye, PC

20070134765 - Recombinant bacteria and uses thereof: The present inventions provides recombinant bacteria selected from K37, RR1, W3110, a mutant of any thereof, and a strain derived from one of these strains, wherein said bacterium contains a gene which encodes an exogenous polymerase and which is under the control of an inducible promoter, as well as uses... Agent: Needle & Rosenberg, P.C.

20070134767 - Hiv-dependent expression constructs and uses therefor: The present invention provides nucleic acid molecules comprising expressible sequences, including reporter genes and therapeutic genes, whose expression is dependent on the presence of both HIV Tat and Rev proteins. Further provided are methods for detecting HIV, method for identifying compounds that can inhibit HIV infection and/or gene expression, methods... Agent: Edwards Angell Palmer & Dodge LLP (client Reference No. 47992)

20070134768 - Methods for the preparation of a fine chemical by fermentation: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., lactate dehydrogenase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way... Agent: Lahive & Cockfield, LLP

20070134769 - Thermostable omega-transaminases: Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereoselectively one of a pair of chiral amines in which the amino group is bound... Agent: Banner & Witcoff, Ltd.

20070134770 - Thermostable omega-transaminases: Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereoselectively one of a pair of chiral amines in which the amino group is bound... Agent: Banner & Witcoff, Ltd.

20070134771 - Thermostable omega-transaminases: Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereoselectively one of a pair of chiral amines in which the amino group is bound... Agent: Banner & Witcoff, Ltd.

20070134772 - Thermostable omega-transaminases: Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich enantiomerically a mixture of chiral amines or to synthesize stereoselectively one of a pair of chiral amines in which the amino group is bound... Agent: Banner & Witcoff, Ltd.

20070134773 - Method for producing l-glutamic acid by fermentation accompanied by precipitation: A microorganism which can metabolize a carbon source at a specific pH in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source, and has ability to accumulate L-glutamic acid in an amount exceeding the amount corresponding to the saturation concentration in the liquid medium at... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070134774 - Process for the production of piperidine derivatives with microorganisms: in the presence of a microorganism under conditions effective to produce the product compound. The microorganism can be from the genus Streptomyces, Stemphylium, Gliocladium, Bacillus, Botrytis, Cyathus, Rhizopus, Pycniodosphora, Pseudomonas, Helicostylum, Aspergillus, Mucor, Gelasinospora, Rhodotorula, Candida, Mycobacterium, or Penicillium. Alternatively, the microorganism can be Cunninghamella bainieri.... Agent: Heslin Rothenberg Farley & Mesiti PC

20070134775 - Process for producing lactonase and utilization thereof: It has been required to economically produce a large amount of optically active γ-lactone derivatives (for example, pantolactone), which are useful as intermediates in synthesizing useful substances such as pharmaceutical drugs. To achieve this object, it is advantageous to employ an enzymatic technique of asymmetric hydrolysis with a hydrolyzing enzyme... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070134776 - Method for producing phosholipid: A method for producing a phospholipid using transphosphatidylation, which comprises homogenizing a mixture of a raw material phospholipid, a hydroxyl-containing acceptor, phospholipase D, and water in the absence of an organic solvent to obtain a homogenized mixture; and subjecting the homogenized mixture to a transphosphatidylation reaction at 15° C. to... Agent: Frishauf, Holtz, Goodman & Chick, PC

20070134778 - Compositions and methods for the synthesis and subsequent modification of uridine-5'-diphosphosulfoquinovose (udp-sq): The present invention is directed to compositions and methods related to the synthesis and modification of uridine-5′-diphospho-sulfoquinovose (UDP-SQ). In particular, the methods of the present invention comprise the utilization of recombinant enzymes from Arabidopsis thaliana, UDP-glucose, and a sulfur donor to synthesize UDP-SQ, and the subsequent modification of UDP-SQ to... Agent: Medlen & Carroll, LLP

20070134777 - Process for improving enzymatic degumming of vegetable oils and reducing fouling of downstream processing equipment: A process controls enzymatic degumming characteristics which cause fouling of post-reactor equipment of industrial scale processing of edible oils. An anti-fouling agent including an organic or mineral acid is added after the reactor and before any post-reactor equipment such as heat exchangers and centrifuges. Typically the anti-fouling agent is added... Agent: Cook, Alex, Mcfarron, Manzo, Cummings & Mehler Ltd

20070134779 - Enzymes useful for changing the properties of polyester: A method is provided for enzymatically modifying a polyester resin, film, fiber, yarn, fabric or textile to modify the characteristics thereof.... Agent: Genencor International, Inc. Attention: Legal Department

20070134780 - Fermentation processes and compositions: The present invention provides improved fermentation processes, including for use in an ethanol production process. The improved fermentation processes include applying at least one fatty acid oxidizing enzyme (especially a lipoxygenase) in a fermentation process. The improved fermentation process may also involve the addition of various additional enzymes and growth... Agent: Novozymes North America, Inc.

20070134781 - Method for producing bioethanol from a lignocellulosicbiomass and recycled paper sludge: A method producing ethanol by combining an plant fiber material containing calcium carbonate with at least one lignocellulosic agricultural residue into a mixture. The plant fiber material can be a paper sludge. The mixture is then hydrolyzed and the resultant hydrolysate is then fermented into ethanol.... Agent: Greenberg Traurig, LLP

20070134782 - Cell lysis device: A micromachined cell lysis device with electrodes that are spaced by less than 10 μm from one another. The cells are attracted to the space between the electrodes and then lysed.... Agent: Foley And Lardner LLP Suite 500

20070134783 - Immature unialgal culture strain: It is intended to provide a novel unialgal culture strain showing a high culture efficiency of a large-sized red alga which is immature, can be stored and cultured over a long period of time and has at least one of the following properties, i.e., producing a physiologically active substance at... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070134785 - Dna hybridization device and method: An apparatus and method for DNA hybridization is provided. The apparatus and method work in conjunction with a substrate comprising an upper surface having probes. The apparatus may comprise a material which abuts the substrate, with at least a portion of the material being pliable. The material and the substrate... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070134784 - Microreplicated microarrays: A microarray comprises a microstructured surface and an attachment chemistry layer disposed on at least a portion of the microstructured surface, the microstructured surface comprising primary microstructured elements comprising walls.... Agent: 3m Innovative Properties Company

20070134786 - Assaying device for determining activity value of nattokinase solution: An assaying device for determining the activity value of Nattokinase solution includes a container having a testing solution therein. Because the testing solution can react with a Nattokinase solution and the reacted testing solution has a different color from the original testing solution, when the testing solution contacts a Nattokinase... Agent: Hdsl

20070134787 - Living cell observing cell: A living cell observing cell capable of measuring a surface of a membrane of a living cell or a rear surface side thereof and accurately performing structural analysis is provided. The living cell observing cell is used to culture at least one cell in a culture solution and observe the... Agent: Bruce L. Adams, Esq. Suite 1231

20070134790 - A cell culture bioreactor: A cell culture bioreactor having a culture chamber for cell growth, a culture medium reservoir mounted externally to the culture chamber, a fluid circulation mechanism for moving culture medium from the reservoir through the culture chamber, and an aerating mechanism for introducing air into and removing air from the culture... Agent: Shyamala T.rajender Rajender Law Offices

20070134791 - Cells for detection of enteroviruses: The invention provides cell lines which are useful for the rapid detection of enteroviruses. In particular, the invention provides transgenic African green monkey kidney cell lines and buffalo green monkey kidney cell lines. The invention provides cell lines which have increased sensitivity to infection by enteroviruses in single-cell type and... Agent: Medlen & Carroll, LLP

20070134788 - Manipulation of chemical and/or biological species using magnetic field modulators: The present invention relates to methods and apparatus for manipulating chemical and/or biological species (e.g., cells) and, more specifically, to methods and apparatus for manipulating chemical and/or biological species using magnetic fields. In one embodiment, a method of manipulating cells involves the patterning of cells using a magnetic field modulator,... Agent: Wolf Greenfield & Sacks, P.C.

20070134789 - Proliferation of hepatocyte precursors: A composition which comprises an animal cell population which contains immature animal cells. The immature animal cells are characterized by expression of alpha-fetoprotein or lack of essential expression of alpha-fetoprotein and albumin, and at least a portion of said immature animal cells or at least a portion of the progeny... Agent: Foley And Lardner LLP Suite 500

20070134793 - Redifferentiation medium for making dedifferentiated chondrocyte to be redifferentiated into chondrocyte: The object of the invention is to provide a redifferention medium and a redifferention method for making dedifferentiated chondrocyte to be redifferentiated into original chondrocyte, the dedifferentiated chondrocyte having attenuated cartilage characteristics due to dedifferentiation during in vitro culture. Accordingly, the invention provides a redifferention medium which is used for... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070134792 - Stem cells and signals developed for use in tissue and organ repair and replacement: Methods and compositions for repairing tissue. Certain embodiments of the invention involve transdifferentiation of cells in a manner not heretofore provided for. One embodiment of the invention features methods for producing stem cells. These methods can involve exposing cells (e.g., human fibroblasts) to a processed or activated egg extract (e.g.,... Agent: Fish & Richardson PC

20070134794 - Strategies for the identification and isolation of cancer stem cells and non-cancerous stem cells: The present invention, in some embodiments, describes methods for selecting and enriching specific types of stem cells and/or progenitor cells from a sample containing at least two different types of stem cells and/or progenitor cells. In one embodiment, the method involves selecting and enriching cancer stem cells and/or cancer progenitor... Agent: Wolf Greenfield & Sacks, P.C.

20070134795 - Flp-mediated recombination: Compositions and methods useful for homologous recombination and stable integration of a polynucleotide into a host cell are provided. The disclosed compositions and methods provide a rapid and efficient method for stably integrating an exogenous polynucleotide into a host cell and selecting such transformed cells.... Agent: Fish & Richardson PC

20070134796 - Targeted integration and expression of exogenous nucleic acid sequences: Disclosed herein are methods and compositions for targeted integration of a exogenous sequence into a predetermined target site in a genome for use, for example, in protein expression and gene inactivation.... Agent: Robins & Pasternak

  
06/07/2007 > patent applications in patent subcategories. archive of inventions by patent app class

20070128585 - (+)-trans-4-(1-aminoethyl)-1-(4-pyridycarbamoyl)-cyclohexane and method for promoting neural growth in the central nervous system and in a patient at a site of neuronal lesion: The invention relates to an antagonist of one or more of Rho family members having ability to elicit neurite outgrowth from cultured neurons in an assay method which includes culturing neurons on a substrate that incorporates a growth-inhibiting amount of Rho family member and exposing the cultured neurons to a... Agent: Fish & Richardson P.C.

20070128584 - Method for isolation of cells: A method is disclosed for separating selected cells that have cell membranes which are selectively-permeable to a given solute from other non-selected cells. The combination of cells are exposed to the given solute and thereafter the cells are exposed to low or zero-solute solution to thereby osmotically shock and destroy... Agent: Floyd B. Carothers Carothers And Carothers

20070128588 - Detection and typing of human papillomavirus using pna probes: The invention provides methods for detection and typing of HPV infection using PNA probes. More specifically, methods are provided for detecting high-risk types of HPV infection with minimal numbers of PNA probes or using PNA probes to selectively amplify only high-risk types of HPV... Agent: Cytyc Corporation

20070128587 - Method of diagnosis of foot and mouth disease and the diagnostic kit: The present invention provides a method for diagnosing foot-and-mouth disease virus infection, comprising the steps of applying a predetermined amount of a test sample to a loading region of a strip; coupling a detection reagent including a given labeling reagent to an analyte of interest in the test sample to... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070128589 - Substrates, sensors, and methods for assessing conditions in females: Described herein are substrates, methods, articles, and kits that are useful for detecting a condition in a female mammal. The substrates interact with one or more proteins (e.g., an enzyme) produced by a microorganism or the female animal. The substrates are labelled in order to produce a visible signal (e.g.,... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070128586 - Therapeutic, prophylactic and diagnostic agents: The present invention provides compounds useful in the treatment and prophylaxis of infection in mammals and avian species by pathogenic agents such as, but not limited to, viruses. The present invention further provides compounds useful in the treatment of other disease conditions such as cirrhosis and hepatocellular carcinoma. The present... Agent: The Mccallum Law Firm

20070128616 - Aggrecanase molecules: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20070128600 - Alpha macroglobulin family member: This invention relates to a protein, termed INSP097, herein identified as a member of the alpha macroglobulin family, in particular as an alpha-2-macroglobulin-like proteinase inhibitor, and to the use of this protein and nucleic acid sequences from the encoding gene in the diagnosis, prevention and treatment of disease.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070128621 - Analyzing messenger rna and micro rna in the same reaction mixture: The present teachings provide methods, compositions, and kits for performing primer extension reactions on at least two target polynucleotides in the same reaction mixture. In some embodiments, a reverse transcription reaction is performed on a first target polynucleotide with a hot start primer comprising a self-complementary stem and a loop,... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070128626 - Assessing response to anti-cd20 therapy by genotyping c1q components: The present invention encompasses methods for predicting metastasis in cancer by assessing the structure of the complement protein C1qA. The methods may encompass examining either protein or nucleic acids, and may further include making treatment decisions based on the predictive methods.... Agent: Fulbright & Jaworski L.L.P.

20070128623 - Biomolecule interaction using atomic force microscope: The present patent application describes a cantilever for atomic force microscopy (AFM), which includes a cantilever body having a fixed end and a free end, the free end having a surface region being chemically modified by a dendron in which a plurality of termini of the branched region of the... Agent: Jhk Law

20070128655 - Breast, gastric and prostate cancer associated antigens and uses therefor: Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in breast, gastric and prostate cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with cancer. The invention... Agent: Wolf Greenfield & Sacks, P.C.

20070128633 - Cell-free protein expression systems and methods of use thereof: Provided herein are in vitro (cell-free) protein translation (IVT) systems for the expression of kinases. In particular, provided herein is an IVT system for the expression of a panel of protein tyrosine kinases (PTK), (e.g., receptor protein tyrosine kinases (RTK) and/or cytoplasmic tyrosine kinases (CTK)), and/or fragments thereof (e.g., kinase... Agent: Jones Day

20070128622 - Chimeric human growth hormone derived from the placenta and pituitary isoform and processes for obtaining said chimera: Our invention relates to a new way of preparing coding DNA constructs, by making a chimera of various coding region isoforms. For example, our method has been successfully used to make a new hGH-NV cDNA chimera having SEQ ID NO: 3, by combining the cDNA isoforms of human placenta and... Agent: Pharmaceutical Patent Attorneys, LLC

20070128629 - Class i sequence based typing of hla-a, -b, and -c alleles by direct dna sequencing: There is provided a method for directly typing or sequencing HLA-A, -B, or -C alleles from a tissue sample wherein exons 2 and 3 of the HLA-A, -B, or -C alleles from the sample are amplified together in a locus specific manner and then separated out and individually amplified in... Agent: Dunlap, Codding & Rogers P.C.

20070128609 - Ddr2 protein with activated kinase activity and preparation method thereof: The present invention relates to a protein containing a modified DDR (Discoidin Domain Receptor) 2 cytosolic tyrosine kinase domain having an increased autophosphorylation and tyrosine kinase activity; a method for preparing a large amount of a protein containing DDR2 cytosolic tyrosine kinase domain, having an increased autophosphorylation and tyrosine kinase... Agent: Darby & Darby P.C.

20070128603 - Diagnostic and therapeutics for diseases associated with 5-hydroxytryptamine (serotonin) receptor 7 (5-ht7): The invention provides a human 5-HT7 which is associated with the cardiovascular disorders, dermatological disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, metabolic diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention... Agent: Banner & Witcoff, Ltd.

20070128656 - Direct fluorescent label incorporation via 1st strand cdna synthesis: The present invention provides for highly efficient fluorescent label incorporation during 1st strand complimentary DNA (cDNA) synthesis. This is achieved by the use of labeled random primers (including, but not limited to, random hexamers, septamers, octamers, nonamers and decamers) rather than labeled nucleotides. This invention thus bypasses the well known... Agent: Smith Hopen, Pa

20070128612 - Dna family tree kit: A DNA family tree kit includes a storage case configured to receive a plurality of DNA storage boxes, a variety of mechanisms for collecting samples of DNA family members and a genealogical organization system that includes a family tree. A method of collecting, storing and categorizing DNA includes collecting at... Agent: Boyle Fredrickson Newholm Stein & Gratz, S.c.

20070128625 - Drug-resistant mutants of hepatitis c virus: The present invention provides nucleotides, peptides, HCV mutants, and cell lines containing mutations associated with drug resistance. In addition, the present invention provides methods for screening for therapeutic compounds capable of inhibiting HCV as well as methods for inhibiting HCV, e.g., by targeting specific binding sites associated with HCV drug... Agent: Intellectual Property Department Gilead Sciences, Inc.

20070128644 - Fluid control method and fluid control apparatus: The object of the present invention is to enable a probe to uniformly encounter biopolymers in a sample solution, regardless of a position in a reaction chamber. In the present invention, a fluid displacement between a reaction chamber and ports communicating therewith in a biochemical reaction part is controlled by... Agent: Fitzpatrick Cella Harper & Scinto

20070128652 - Fluid processing device comprising radial channels: The present invention provides, in one aspect, an apparatus that comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i)... Agent: Kilyk & Bowersox, P.l.l.c.

20070128631 - Gene finding using ordered sets: A method and system for finding in a DNA sequence, a gene represented by an ordered set of marker strings. Sub-strings in the DNA sequence matching each marker string are identified. In a set ordered via occurrence of the marker strings in the ordered set of marker strings, the score... Agent: Schmeiser, Olsen & Watts

20070128620 - Hot start reverse transcription by primer design: The present teachings provide methods, compositions, and kits for performing primer extension reactions. In some embodiments, a reverse transcription reaction is performed on a target polynucleotide with a hot start primer comprising a blunt-ended self-complementary stem, and a loop, and extension products form at high temperatures but reduce extension product... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070128630 - Hpv cd8+ t-cell epitopes: The present invention provides means to identify functional CD8+ T-cell epitopes in any protein of interest. The present invention further provides CD8+ T-cell epitopes of various proteins. In additional embodiments, the present invention provides epitopes suitable for use in prophylactic and/or therapeutic vaccines. In particularly preferred embodiments, the present invention... Agent: Genencor International, Inc. Attention: Legal Department

20070128619 - Human fgf-21 gene and gene expression products: This invention relates to human fibroblast growth factor (hFGF-21), and to variants thereof and to polynucleotides encoding FGF-2 1. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to methods of treating liver disease such as cirrhosis and cancer,... Agent: Davis Wright Tremaine, LLP

20070128653 - Human hac3: The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes... Agent: Townsend And Townsend And Crew, LLP

20070128646 - Hybridization of pna probes in alcohol solutions: This invention features methods, kits and compositions for hybridization of PNA probes in diagnostic applications. This invention is further directed toward the use of said methods, kits and compositions for both fixation of cells and hybridization to nucleic acid targets within fixed cells.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070128617 - Hybridization-mediated analysis of polymorphisms: Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is... Agent: Eric P. Mirabez

20070128601 - Identification and characterization of racemases, definition of protein signatures, and a test for detecting d-amino acid and for screening molecules capable of inhibiting the activity of racemase, especially proline racemase: This invention relates to the identification and characterization of racemases and definition of protein signatures of these racemases. More particularly, this invention relates to the identification of nucleic acid molecules encoding a peptide consisting of a motif characteristic of the protein signatures, and to the peptides consisting of these motifs... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070128637 - Identification of oligonucleotides for the capture, detection and quantitation of west nile virus: West Nile virus capture oligonucleotides, primers and probes derived from conserved regions of the West Nile virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes.... Agent: Novartis Vaccines And Diagnostics Inc.

20070128638 - Identification of oligonucleotides for the capture, detection and quantitation of west nile virus: West Nile virus capture oligonucleotides, primers and probes derived from conserved regions of the West Nile virus genome are disclosed. Also disclosed are nucleic acid-based assays using the capture oligonucleotides, primers and probes.... Agent: Novartis Vaccines And Diagnostics Inc.

20070128592 - Method and nucleic acids for the analysis of a lung cell proliferative disorder: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of lung cell proliferative disorders,... Agent: Davis Wright Tremaine, LLP

20070128643 - Method for assaying nucleic acid fragment and kit thereof: The present invention is related to a novel method for assaying high quantity of nucleic acid fragments, by using the single-stranded anchor nucleic acid probe with biotin and this single-stranded anchor nucleic acid hereto form double-stranded nucleic acid with the target nucleic acid fragment. To detect the target fragment does... Agent: Yang-chuen Yeh

20070128607 - Method for distinguishing aml subtypes with different gene dosages: Disclosed is a method for distinguishing AML subtypes with different gene dosages selected from AML-TRI8, AML-TRI11, AML-TRI13, AML-MO7, and/or AML-DEL5q in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.... Agent: Roche Molecular Systems Inc Patent Law Department

20070128599 - Method for improved diagnosis of dysplasias: The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without... Agent: Howrey LLP

20070128642 - Method of isolation and self-assembly of small protein particles from blood and other biological materials: Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are comprised of misfolded proteins. Also provided are compositions and methods for the isolation and manipulation... Agent: Andrus, Sceales, Starke & Sawall, LLP

20070128624 - Method of preparing libraries of template polynucleotides: The present invention relates to a method for preparing a library of template polynucleotides and use thereof in methods of solid-phase nucleic acid amplification. More specifically, the invention relates to a method for preparing a library of template polynucleotides that have common sequences at their 5′ ends and at their... Agent: Klauber & Jackson

20070128632 - Methods for amplification of nucleic acids using spanning primers: The teachings relate to methods and kits for detecting whether target nucleic acid sequences are present and/or quantitating target nucleic acid sequences.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070128615 - Methods for determining nucleotide sequence information: Provided herein, is a nucleic acid sequencing method based on detection of Raman signatures of oligonucleotide probes. Raman signatures of individually captured nucleic acid probes, optionally labeled by a Raman label or a positively charged enhancer, are detected. The sequences of captured probes are used to identify the nucleotide sequences... Agent: Raj S. Dave Morrison & Foerster LLP

20070128590 - Methods for determining therapeutic resonant frequencies: Methods are provided for readily and efficiently determining resonant frequencies that can be used therapeutically or beneficially, for debilitation of specific types of genomic materials, including DNA and/or RNA, genes, and gene sections. The methods can be used in a variety of circumstances related to various human and animal diseases... Agent: Charlene A. Boehm

20070128591 - Methods for diagnosing and treating diseases and conditions of the digestive system and cancer: The invention provides methods of diagnosing diseases and conditions of the digestive system and cancer, methods for identifying compounds that can be used to treat or to prevent such diseases and conditions, and methods of using these compounds to treat or to prevent such diseases and conditions. Also provided in... Agent: Clark & Elbing LLP

20070128598 - Methods for generating rna copies: The present invention is directed to a novel method of efficiently synthesizing, in a non-specific manner, multiple copies of a target RNA. The present invention also relates to kits relating to the same and the use of these copies for determining gene expression pattern. In particular, the present invention relates... Agent: Amster, Rothstein & Ebenstein LLP

20070128647 - Methods for high throughput genotyping: Methods for genotyping polymorphisms using allele specific probes are disclosed. A training set is used to generate a model for each polymorphism to be interrogated. The training set is used to obtain an estimate of the asymmetry between an intensity measurement for a first allele and an intensity measurement for... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070128648 - Methods for the identification of ikkalpha function and other genes useful for treatment of inflammatory diseases: The invention provides a method for identifying genes involved in the NF-κB pathway comprised of the steps of determining the level of expression of a gene in an experimental sample obtained from the cells having deficient levels of a component of the NF-κB pathway; determining the level of expression of... Agent: Michael P. Morris Boehringer Ingelheim Corporation

20070128639 - Molecular profiling of cancer: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides cancer markers useful in the diagnosis and characterization of prostate and breast cancers.... Agent: Medlen & Carroll, LLP

20070128611 - Negative control probes: In an embodiment, a method is included for generating a negative control probe sequence for an array including selecting biological probe sequences from the array randomly, generating a plurality of candidate probe sequences by randomly permuting the selected biological probe sequence, and screening the candidate probe sequences for sequence similarity... Agent: Agilent Technologies Inc.

20070128627 - Novel cofactor that modulates steroid receptor activities: The invention provides a new glucocorticoid receptor coactivator named STAMP (Steroid receptor coactivator-1 and Transcription intermediary factor-2 Associated Modulatory Protein) that can modulate transcription of glucocorticoid-, progesterone-, mineralocorticoid- and androgen-responsive genes. The invention also provides antibodies that can bind STAMP and modulate its activity. In addition, the invention provides antisense,... Agent: Schwegman, Lundberg, Woessner & Kluth/nih

20070128608 - Novel mixtures for assaying nucleic acid, novel method of assaying nucleic acid with the use of the same and nucleic acid probe to be used therefor: [Problems] To provide a novel mixture for assaying a target nucleic acid, characterized by enabling a nucleic acid assay while: 1) requiring no step of diluting the target nucleic acid; 2) requiring no procedure of changing a probe concentration depending on a concentration of the target nucleic acid. [Means for... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070128595 - Novel polynucleotide and polypeptide sequences and uses thereof: The present invention provides a purified nucleic acid encoding a putative transmembrane receptor polypeptide comprising at its N-terminus leucine rich repeats and at least an immunoglobulin domain. S30-21616/DEGA polypeptide of the present invention, analogs of said polypeptide, vectors and host cells that embody the polynucleotides, bio-immunopharmaceutical compositions and diagnostic reagents... Agent: Kenyon & Kenyon LLP

20070128614 - Nucleotide analogs: The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.... Agent: Goodwin Procter LLP Patent Administrator

20070128613 - Pcr based capsular typing method: The present invention relates to molecular diagnostics. In particular, the present invention relates to PCR based diagnostics for the typing of Group B streptococci.... Agent: Medlen & Carroll, LLP

20070128602 - Polynucleotide associated with a colon cancer comprising single nucleotide poylmorphism, microarray and diagnostic kit comprising the same and method for diagnosing a colon cancer using the polynucleotide: Provided is a polynucleotide including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1-12 and including a nucleotide at position 101 of the nucleotide sequence, or a complementary polynucleotide thereof.... Agent: Soonja Bae Cantor Colburn

20070128636 - Predictors of patient response to treatment with egfr inhibitors: The invention concerns genes and gene sets and methods useful in the prediction of the response of a cancer patient to treatment with an epidermal growth factor receptor (EGFR) inhibitor.... Agent: Heller Ehrman LLP

20070128606 - Prkcs as modifiers of the beta catenin pathway and methods of use: Human PRKC genes are identified as modulators of the beta catenin pathway, and thus are therapeutic targets for disorders associated with defective beta catenin function. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of PRKC are provided.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070128651 - Promoter sequences and the use thereof: The promoter region and various fragments thereof for the yellow fever mosquito (Aedes aegypti) ribonucleotide reductase small subunit (R2) are disclosed. Nucleic acids and host cells that contain the promoter sequences are also disclosed. Further disclosed are various methods involving the use of these sequences.... Agent: Quarles & Brady LLP

20070128594 - Protein c polymorphisms: The invention provides methods and kits for obtaining a prognosis for a patient having or at risk of developing an inflammatory condition. The method generally comprises determining a protein C promoter genotype of a patient for a polymorphism in the protein C promoter region of the patient, comparing the determined... Agent: Mckenna Long & Aldridge LLP

20070128596 - Reagents and methods for identifying and modulating expression of tumor senescence genes: This invention identifies tumor senescence genes induced by treatment with cytotoxic agents. The invention provides reagents and methods for identifying compounds that induce expression of these cellular genes and produce cellular senescence, particularly senescence in tumor cells. The invention also provides reagents that are recombinant mammalian cells containing recombinant expression... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070128610 - Sample preparation method and apparatus for nucleic acid sequencing: The invention provides methods and apparatus for preparation and sequencing of nucleic acids.... Agent: Proskauer Rose LLP

20070128635 - Selected amplification of polynucleotides: The invention provides methods and compositions for selectively amplifying one or more target polynucleotides in a sample. In one aspect, a plurality of selection oligonucleotides are provided that are capable of simultaneously annealing to separate regions of a target polynucleotide to form a complex that is enzymatically converted into a... Agent: Stephen C. Macevicz

20070128634 - Separation and purification of nucleic acid from paraffin-containing samples: Disclosed are rapid and reproducible methods for separating and purifying nucleic acids from paraffin-containing tissue samples. The disclosed methods involve a melting step, where paraffin-containing tissue samples are heated in the presence of a detergent, causing the paraffin to melt and tissue sample cells to lyse. From the resulting two-phase... Agent: Invitrogen Corporation C/o Intellevate

20070128593 - Sga-1m, a cancer associated antigen, and uses thereof: The present invention relates to a gene and gene product, SGA-1M that is differentially expressed in cancer tissues and cell lines. Suppression Subtractive Hybridization and microarray screening were used to screen for differential expression of SGA-1M in cancer tissues and cell lines. Expression analysis has demonstrated overexpression of SGA-1M in... Agent: Seattle Genetics, Inc.

20070128597 - Single nucleotide polymorphisms sensitively predicting adverse drug reactions (adr) and drug efficacy: Single Nucleotide Polymorphisms sensitively predicting Advserse Drug Reactions (ADR) and Drug Efficacy Abs tract. The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c

20070128641 - Sirna targeting hypoxia-inducible factor 1: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.... Agent: Kalow & Springut LLP

20070128640 - Sirna targeting ras-related nuclear protein: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.... Agent: Kalow & Springut LLP

20070128650 - Solid phase rflp-based snp detection: The invention is directed to a method for detection of single nucleotide polymorphisms utilizing a solid phase RFLP-based method of detection. The invention further relates to a method of detecting a single nucleotide polymorphism (SNP) comprising providing a sample test DNA molecule containing an SNP site of interest; detectably labeling... Agent: The Mccallum Law Firm, P. C.

20070128649 - Synthesis of error-minimized nucleic acid molecules: A method is provided for synthesis of error-minimized nucleic acid molecules. Oligonucleotides intended to have fragments of a desired, full-length nucleotide sequence, and optionally containing other desired nucleotides, such as nucleotides for binding the oligonucleotides to a substrate, are obtained. Oligonucleotides for both strands of the desired, full-length sequence may... Agent: Carr & Ferrell LLP

20070128618 - Systems and methods for characterization of molecules: The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as... Agent: Wolf Greenfield & Sacks, P.C.

20070128605 - Triacylglycerol-deficient fission yeast and its uses: A fission yeast having non-functional dga1 and plh1 genes, which is incapable of synthesizing triacylglycerols, is disclosed. The fission yeast is susceptible to lipotoxicity including lipoapoptosis, and is useful for screening of compounds that inhibit or prevent lipotoxicity or lipoapoptosis. The fission yeast strain may be transformed to express a... Agent: Townsend And Townsend And Crew, LLP

20070128628 - Universal method for selective amplification of mrnas: The invention relates generally to methods for the amplification of ribonucleic acids, including for example messenger ribonucleic acids (mRNAs). In an embodiment, the invention also relates to kits for amplifying ribonucleic acids, including for example mRNAs. In another embodiment, the invention relates to kits comprising the components for performing the... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20070128654 - Universal-tagged oligonucleotide primers and methods of use: The present invention relates to universal-tagged oligonucleotide primers, and to methods of using the primers for amplifying the genome.... Agent: Knobbe Martens Olson & Bear LLP

20070128645 - Use of kiaa0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development: An object of the present invention is to provide use of the KIAA0172 gene in treatment and diagnosis of diseases as well as in pharmaceutical development. An agent for treating cancer which comprises as an active ingredient a polypeptide encoded by the KIAA0172 gene, a partial sequence thereof or a... Agent: Foley And Lardner LLP Suite 500

20070128604 - Variants of human taste receptor genes: Identified herein are different forms of bitter receptor genes that occur in different humans. These alleles are generated by numerous coding single nucleotide polymorphisms (cSNP's) that occur within the members of the T2R gene family. Some SNP's cause amino acid substitutions, while others introduce chain termination codons, rendering the allele... Agent: Klarquist Sparkman, LLP

20070128658 - Fluorescent dyes, methods and uses thereof: The present invention provides a method for identifying and characterizing candidate fluorescent molecules. This method involves the generation of spatially addressed arrays of heterocyclic compounds which are candidate fluorescent molecules. The spatially addressed array can be used to identify fluorescent molecules among the candidate molecules. The spatially addressed array can... Agent: Greenlee Winner And Sullivan P C

20070128659 - Hydrophilic labels for biomolecules: Compounds, compositions, and methods for optical, including fluorescence optical, determinations useful in labelling biomolecules such as protein and deoxyribonucleic acid for their detection and quantitation. The compounds are diasteromeric cyanines with high hydrophilicity and other desirable properties.... Agent: Wood, Herron & Evans, LLP

20070128663 - Method and apparatus for mass spectrometric immunoassay analysis of specific biological fluid proteins: Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins and their variants that are present in complex biological fluids or extracts. Protein and variant levels can be determined using quantitative methods in which the protein/variant signals are normalized to signals of internal reference standard... Agent: Snell & Wilmer L.L.P. (main)

20070128660 - Methods for detecting weakly immunogenic analytes: GPE antibodies recognize GPE with high specificity. When used in a radioimmunoassay, they reliably measure the concentration of GPE. They may be used to extend the half-life of GPE both in vivo and in vitro, and in methods of purifying the GPE receptor. Two methods of rpHPLC accurately revolve GPE... Agent: Fliesler Meyer LLP

20070128661 - Modulation of il-2 production by t-bet: The instant invention is based, at least in part, on the dentification of a mechanism by which T-bet modulates IL2 production. The present invention pertains to methods of identifying agents that modulate the kinase-mediated interaction of T-bet with RelA, as well as methods of use therefore.... Agent: Lahive & Cockfield, LLP

20070128657 - Molecular libraries: c) analysing the host cell population to determine the effect of the peptides of formula M-G/M/V—(X)n on a reporter system. Also describe are a library of nucleic acid constructs which can express free peptides in an intra-cellular environment, said peptides having the sequence M-G/M/V—(X)n, wherein n is an integer from... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070128662 - Photoreactive regulator of protein function and methods of use thereof: The present invention provides a synthetic regulator of protein function, which regulator is a light-sensitive regulator. The present invention further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present invention further provides methods of modulating protein... Agent: Bozicevic, Field & Francis LLP

20070128665 - Methods for identifying compounds interacting with small membrane-bound gtp-ases: A method for identifying a compound capable of promoting deactivation of, or inhibiting activation of, a membrane bound active small GTPase, comprising incubating a live cell expressing the small GTPase and having a small GTPase specific reporter thereof in the presence of a test compound and monitoring association of the... Agent: Goodwin Procter LLP Patent Administrator

20070128668 - Quantitative use of tracer cells: A method is provided for the quantitative assessment of cell deposition onto a planar surface. In particular, the present invention provides a method of measure the quantitative transfer of labeled tracer cells to a glass slide to evaluate the effectiveness of and uniformity of cell transfer to the surface of... Agent: Theodore Allen, Esq. Cytyc Corporation

20070128667 - Secreted neural apoptosis inhibiting proteins: A novel neuroprotectant was identified by microarray analysis that is differentially expressed between the ventricular zone and the cortex of human adult and fetal brain. The secreted protein antagonizes Wnt action in Xenopus embryos. Methods are described for modulating free radical neurotoxicity by contacting cells with the protein, treating neuronal... Agent: Ross J. Oehler Sanofi-aventis U.s. LLC

20070128664 - Secreted polypeptide species associated with cardiovascular disorders: The invention discloses human secreted polypeptides that circulate at an increased level in the plasma of patients with cardiovascular disorders. The invention also provides methods of using compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for these polypeptides, for diagnosis, prognosis, and for drug development.... Agent: Novartis Corporate Intellectual Property

20070128669 - Serum-free expansion of cells in culture: Methods and agents are disclosed for modulating the interaction of β-catenin or γ-catenin with CBP or p300. Agents that increase the binding of CBP to β-catenin are associated with enhancing the β-catenin-related proliferation of adult stem cells, including hematopoietic stem cells, neural stem cells, skin stem cells, and pancreatic stem... Agent: Davis Wright Tremaine, LLP

20070128666 - Ttbks as modifiers of the beta catenin pathway and methods of use: Human TBK genes are identified as modulators of the beta catenin pathway, and thus are therapeutic targets for disorders associated with defective beta catenin function. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of TTBK are provided.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070128670 - Methods for the identification and preparation of regulator/suppressor t lymphocytes, compositions and use thereof: The invention relates to the fields of biology, genetics and medicine. The invention describes methods and compositions enabling (1) the identification of suppressor T cells or lymphocytes (Ts) or the precursors thereof (pTs) for diagnostic or therapeutic purposes and for carrying out genomic or proteomic studies, particularly for the identification... Agent: Fish & Richardson PC

20070128672 - Anti-p53 antibodies: The present invention relates to nucleotide sequences which encode polypeptides of antibodies against the p53 protein in vertebrates, and to the polypeptides and antibodies (or fragments thereof) encoded by those nucleotide sequences. The invention also relates to nucleotide sequences and polypeptide sequences for use in the development of diagnostic and... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070128676 - Breast cancer related protein, gene encoding the same, and method of diagnosing breast cancer using the protein and gene: An isolated protein having an amino acid sequence of SEQ ID No. 4 and having an activity inducing apoptosis, and a gene encoding the same are provided. Also, a microarray having a substrate on which the gene or fragment thereof is immobilized is provided. Also, a method of diagnosing breast... Agent: Cantor Colburn, LLP

20070128674 - Method of cancer screening and method of cancer treatment: A method of cancer screening comprising the steps of administering the Blood CA 27,29 testing procedure; if the result is positive administering a mammogram; if the result is positive administering an needle biopsy; if the result is positive administering a PET scan; if the result is positive administering a blood... Agent: Michael A. O'neil Michael A. O'neil, P.C.

20070128675 - Method of cancer screening and method of cancer treatment: A method of cancer screening comprising the steps of administering the Blood CA 27,29 testing procedure; if the result is positive administering a mammogram; if the result is positive administering an needle biopsy; if the result is positive administering a PET scan; if the result is positive administering a blood... Agent: Michael A. O'neil Michael A. O'neil, P.C.

20070128671 - Monoclonal antibody specific for the extracellular domain of prostate specific membrane antigen: The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are... Agent: Lahive & Cockfield, LLP

20070128673 - Np95: methods of assaying for cell cycle modulators: The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding NP95, which is involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides,... Agent: Townsend And Townsend And Crew, LLP

20070128677 - Screening assays for agents that alter inhibitor of apoptosis (iap) protein regulation of caspase activity: The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the IAP regulates the activity of the caspases. The... Agent: Mcdermott, Will & Emery

20070128678 - Pknb kinase and pstp phosphatase and methods of identifying inhibitory substances: The present invention relates to a pknB kinase and a pstP phosphatase as well as their use for identifying antibacterial substances.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070128679 - Ultrasensitive bioanalytical assays based on the use of high-gain catalytic chemical amplification: The invention relates to ultrasensitive bioanalytical assays based on the use of high-gain catalytic chemical amplification methods. The ultrasensitive bioanalytical assays of the invention utilize high gain catalytic chemical amplification methods to detect the presence and to quantify the concentrations of target analytes labeled with specific binding reagents or biomarkers... Agent: Jaeckle Fleischmann & Mugel, LLP

20070128680 - Hydrazines and derivatives production process from hydrazines and dicarboxylic acid: The present invention describes a process to form hydrazides from the reaction of a hydrazine and a dicarboxylic, using a Lewis acid as a main reagent of the reaction. The reaction occurs in a safe reactional environment, utilizing smooth conditions, neither involving high temperatures nor high pressures, producing the desired... Agent: Powell Goldstein LLP

20070128681 - Biocompatible chemically crosslinked hydrogels for glucose sensing: An hydrogel incorporating a biologically active component is provided that is useful as an interface material for transdermal sensing applications. Specifically, the hydrogel has a crosslinked gel structure and a biologically active component incorporated into the crosslinked gel structure, the biologically active component being capable of converting glucose into a... Agent: Hunton & Williams LLP Intellectual Property Department

20070128682 - Predictive treatment of dysglycemic excursions associated with diabetes mellitus: A predictive technique for treating diabetes mellitus is described whereby a patient's blood glucose levels are monitored “continuously” over an extended period of time and a life-event diary is maintained records all significant life-events (e.g., food intake, medication, exercise, mood/emotions, etc.). This information is analyzed to derive a mathematical model... Agent: Howard M Cohn Patent Attorney LLC

20070128683 - Metabolic delivery of coenzyme a analogs: Methods to generate analogs of coenzyme A in vitro and in vivo are disclosed. The methods comprise reacting pantetheine or a derivative thereof with a reporter to form labeled pantetheine or a derivative thereof, phosphorylating the labeled pantetheine or derivative thereof to form phosphopantetheine or a derivative thereof, adenylating the... Agent: Woodcock Washburn LLP

20070128684 - Chimeric protein and its use in electron transfer methods: A chimeric protein comprises a redox catalytic domain from one source and an electron transfer A domain from a different source. The protein is used in a method in which a substrate for the redox catalytic domain is acted on, electrons are transferred between the redox catalytic domain and the... Agent: Sughrue Mion, PLLC

20070128685 - Methods and compositions for cell culture: The invention encompasses composition and methods for cell culture and for therapeutic and cosmetic use. The compositions and methods utilize collagenase, e.g., bacterial collagenase, other isolated collagenase, or synthetic collagenase, e.g., recombinant collagenase. One form of collagenase that can be used in some embodiments of the invention is matrix metalloproteinase-1.... Agent: Wilson Sonsini Goodrich & Rosati

20070128686 - Cell isolation method and uses thereof: This invention relates generally to the field of cell separation or isolation. In particular, the invention provides a method for separating cells, which method comprises: a) selectively staining cells to be separated with a dye so that there is a sufficient difference in a separable property of differentially stained cells;... Agent: Morrison & Foerster LLP

20070128688 - Method for cell-free protein synthesis using complementary oligonucleotide: The present invention provides a practical cell-free protein synthesis method capable of easily synthesizing a large amount of protein at low cost. A method for cell-free protein synthesis performed in a reaction solution containing mRNA and a living cell-derived extract solution, the reaction solution containing an oligonucleotide complementary to a... Agent: Rader Fishman & Grauer PLLC

20070128687 - Process for producing dipeptides: The present invention provides a process for producing a dipeptide which comprises: allowing an enzyme source and a diketopiperazine wherein one or two kinds of α-amino acids are condensed with each other to be present in an aqueous medium, said enzyme source being a culture of a microorganism having the... Agent: Nixon & Vanderhye, PC

20070128692 - Chimeric empty capsids of the infectious bursal disease viruse (ibdv), obtainment process and applications: The chimeric empty capsids of the infectious bursal disease virus (IBDV) are constituted by assembly of (i) IBDV pVP2 proteins and (ii) fusion proteins comprising a region A constituted by the IBDV VP3 protein bound to a region B constituted by a heterologous polypeptide comprising a polypeptide of interest, such... Agent: Klarquist Sparkman, LLP

20070128694 - Compositions and methods relating to the daptomycin biosynthetic gene cluster: The invention provides nucleic acid molecules comprising all or a part of a daptomycin biosynthetic gene cluster. The daptomycin biosynthetic gene cluster may be derived from Streptomyces, preferably from S. roseosporus. The invention also provides other nucleic acid molecules from S. roseosporus. The invention further provides polypeptides encoded by the... Agent: Cubist Pharmaceuticals, Inc.

20070128697 - Expression system of nell peptide: Methods of preparing a NELL peptide are disclosed.... Agent: Squire, Sanders & Dempsey L.L.P.

20070128691 - Genomically modified cell neutralized to serum-free system: Development of a host cell capable of producing a glycoprotein composition such as an antibody composition which is useful in development of medicaments is desired. The present invention provides a cell in which a genomic gene encoding an enzyme relating to a sugar chain modification in which 1-position of fucose... Agent: Nixon & Vanderhye, PC

20070128693 - Method for the inactivation and removal of dengue virus from biological samples: A method for inactivating and removing dengue virus from a biological sample comprising the dengue virus and at least one biomolecule of interest, wherein a solvent treatment step is used to inactivate the dengue virus, then a cation exchange chromatography step effectively removes the dengue virus by physically separating it... Agent: EagleIPLimited

20070128699 - Methods of diagnosing cervical cancer: The invention provides reagents and methods for detecting pathogen infections in human samples. This detection utilizes specific proteins to detect the presence of pathogen proteins or abnormal expression of human proteins resulting from pathogen infections. Specific methods, compositions and kits are disclosed herein for the detection of oncogenic Human papillomavirus... Agent: Bozicevic, Field & Francis LLP

20070128700 - Methods to culture circovirus: The present invention relates to methods for culturing circovirus and in particular, porcine circovirus. The present invention provides compositions and methods for culturing porcine circovirus in mammalian cells expressing mammalian adenovirus E1 function.... Agent: Morrison & Foerster LLP

20070128695 - Novel inhibitors of vascular endothelial growth factor activity, their uses and processes for their production: The present invention is directed to novel chimeric VEGF receptor proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including the murine homologue to the human KDR receptor FLK-1, wherein said chimeric VEGF receptor proteins bind to VEGF and antagonize the endothelial... Agent: Merchant & Gould PC

20070128696 - Novel promoters and gene expression method by using the promoters: To provide a promoter, a recombinant DNA, a gene expression vector, an expression vector, and a transformant, which are capable of expressing a gene without inducing gene expression with an inducer; and a method for producing a protein and a kit therefor, which can be operated easily and performed inexpensively... Agent: Birch Stewart Kolasch & Birch

20070128690 - Novel trichoderma genes: Described herein are novel gene sequences isolated from Trichoderma reesei. Two genes encoding proteins comprising a cellulose binding domain, one encoding an arabionfuranosidase and one encoding an acetylxylanesterase are described. The sequences, CIP1 and CIP2, contain a cellulose binding domain. These proteins are especially useful in the textile and detergent... Agent: Victoria L Boyd Genecor International Inc

20070128698 - Peptide constructs for treating autoimmune and related diseases: Conjugated peptides include a first peptide component which is an antigen associated with autoimmune disease, allergy, asthma or transplantation rejection and binds to an antigen-specific receptor on a T cell, and a second peptide component which corresponds to an “antigen presenting molecule” namely, a peptide binding to a T cell... Agent: Roger C. Hahn Hahn & Voight PLLC

20070128689 - Reca-negative and rhab-negative microorganism: The present invention describes new microorganisms specifically for use as expression systems for rhamnose-in-ducible promoters. Due to the combination of rhamnose and recombination deficiency artificially created in these organisms, ex-pression systems which require less of the expensive rhamnose for induction and therefore can be induced more inexpensively, and have a... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070128701 - Monoclonal antibodies against the interferon receptor, with neutralizing activity against type i interferon: The invention relates to a monoclonal antibody directed against the human interferon class I receptor (IFN-R) characterized by the following properties: it recognizes the extracellular domain of the human IFN-R, and it has a neutralizing capacity against the biological properties of the human type I-IFN. It further concerns their use... Agent: Baker Botts, LLP

20070128702 - Methods of creating consumable strains and compositions thereof: Consumable biotech strain improvement products are presented, as well as methods of preparation and using them. The technology is based on reversible, single-crossover insertion vectors, such as plasmids or phage. Because the single crossover event is reversible in the absence of drug selection, the products cannot be maintained in a... Agent: Dykema Gossett PLLC

20070128703 - Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using the same: The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, in order to create a variety of glycosaminoglycan oligosaccharides having a natural or chimeric or hybrid sugar structure with a targeted size... Agent: Dunlap, Codding & Rogers P.C.

20070128704 - Method for producing enantiomer-pure aminoalcohols: The invention relates to a process for preparing enantiomerically pure alcohol of the formula 1, which comprises (i) reducing the ketone of the formula 3 to the racemic alcohol of the formula 4, (ii) enantioselectively acylating the racemic alcohol of the formula 4 with succinic anhydride in the presence of... Agent: Connolly Bove Lodge & Hutz, LLP

20070128705 - Enzymatic process for stereo-selective preparation of chemical compounds in hydrofluorocarbon solvents: A process for preparing a second compound stereo-selectively is described. The process comprises reacting a substrate comprising at least one first compound with a reagent in the presence of a biological catalyst and a solvent comprising at least one (hydro)fluorocarbon so as to convert a first compound into the second... Agent: Cook, Alex, Mcfarron, Manzo, Cummings & Mehler Ltd

20070128706 - Mutated xylose reductase in xylose-fermentation by s. cerevisiae: New xylose-utilizing Saccharomyces cerevisiae mutant strain which ferments xylose to ethanol, wherein the strain expresses a K270M mutated P. stipitis XYL1 gene (1 or 2 copies of the mutated gene) together with the native P. stipitis XYL2 gene and overexpresses the endogenous XKS1 gene.... Agent: Matthew E. Connors Gauthier & Connors LLP

20070128707 - Method for making metal oxides: Embodiments of a method for making metal oxides or mixed metal oxides are disclosed. One representative embodiment comprises selecting a substrate for making the metal oxide or mixed metal oxide, contacting a biological system with the substrate material for an effective period of time, and optionally isolating the metal oxide... Agent: Klarquist Sparkman, LLP

20070128708 - Variable volume electroporation chamber and methods therefore: Disclosed is a chamber apparatus for electroporating in vitro relatively large volumes of a fluid medium carrying biological-cells-or-vesicles wherein-a reservoir for carrying said cells and vesicles is variable in its volume on demand and wherein the volume chosen is directly related to the volume of the sample to be electroporated.... Agent: Biotechnology Law Group C/o Portfolioip

20070128709 - Crystal structure and uses thereof: The present invention relates to X-ray crystallography studies of a human Janus Kinase 2 (JAK2) domain. More particularly, it relates to the crystal structure of a JAK2 kinase domain bound to an inhibitor. The invention further relates to the use of the crystal and related structural information to select and... Agent: Morrison & Foerster LLP

20070128710 - Novel protein associated with cell stress response: A stress-phosphorylated endoplasmic reticulum protein, Nogo B, is provided. The protein is hyperphosphorylated as a result of exposure of cells to stress. Two transcripts of Nogo B are identified in human tissues, and the longer transcript is predominant in human brain tumor samples.... Agent: Novartis Vaccines And Diagnostics Inc.

20070128711 - Chimeric west nile viruses and uses thereof: A chimeric West Nile live virus comprised of the NY99 and WN1415 strains and an infectious DNA recombinant construct encoding for the chimeric virus are provided, as well as immunogenic compositions and their method of use.... Agent: Stinson Morrison Hecker LLP Attn: Patent Group

20070128712 - Treatment of putrescrible cakes: A method of treating putrescible cakes to reduce the E. Coli and odour present in the cake and prevent further odour generation comprising the step of maintaining the cake under substantially anoxic condition in the presence of ammonium and/or nitrate moieties at pH7.5 to pH10.5 for a period of more... Agent: Michael Best & Friedrich, LLP

20070128713 - Triphasic process for gas effluent treatment: A triphasic bioreactor for physico-chemically treating a gas is disclosed. The triphasic bioreactor comprises a reaction chamber with a liquid and biocatalysts in suspension in the liquid, for catalyzing a reaction between the gas and the liquid to obtain a treated gas and a solution containing a reaction product. A... Agent: Ware Fressola Van Der Sluys & Adolphson, LLP

20070128714 - Electrophoresis apparatus having valve system: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having... Agent: Jeffer, Mangels, Butler & Marmaro, LLP

20070128715 - Centimeter-scale, integrated diagnostics incubator for biological culturing: Disclosed are portable, disposable, centimeter-scale, integrated diagnostics incubators for use in biological culturing. An exemplary incubator comprises an optically accessible enclosure having a plurality of fluidic ports. A heating element is disposed within the enclosure that is coupled to an external heater controller. An autoclavable microfluidic perfusion chamber is disposed... Agent: Law Offices Of Kenneth W. Float #2f

20070128716 - Micro-bubble plate for patterning biological and non-biological materials: Systems and methods are provided for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate with regions that will trap gas, usually in the form of bubbles, when the plate is submerged in liquid. Other embodiment... Agent: Orrick, Herrington & Sutcliffe, LLPIPProsecution Department

20070128717 - Dna sequences comprising gene transcription regulatory qualities and methods for detecting and using such dna sequences: The invention is concerned with the systematic elucidation and identification of regulatory sequences. The invention provides among others screenings and detection methods with which regulatory sequences can be identified. The invention further provides regulatory sequences and use thereof in various fields such as, but not limited to protein production, diagnostics,... Agent: Trask Britt

20070128719 - Isolation and expansion of animal cells in cell cultures: Described are methods for isolating/purifying and expanding animal stem cells and stem-cell-like cells. Isolation methods include conditions comprising preferentially digesting non-stem cells and non-stem-cell-like cells in a population and preferentially adhering stem cells and stem-cell-like cells in a population. Expansion methods include culturing such cells under conditions comprising modulation of... Agent: Wilson Sonsini Goodrich & Rosati

20070128720 - Selective culture method and isolation method of small hepatocytes with hialuronic acid: A method of culturing small hepatocytes is provided, which method comprises culturing the small hepatocytes in the presence of a carrier of which surface is attached by hyaluronic acid (hyaluronic acid-attached carrier) and/or in the presence of a carrier of which a major component is hyaluronic acid. Additionally, a method... Agent: Hoffmann & Baron, LLP

20070128718 - System for cell culture: The present invention provides a novel apparatus to grow cells or microorganisms where the cultivation chamber is partially filled with liquid cultivation medium and cells. The wave induction mechanism lifts up between 5 and 50 % of the length of the culture chamber. Mixing and aeration is achieved by inducing... Agent: Bell, Boyd & Lloyd LLP

20070128721 - Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use: The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E1/E2 characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried... Agent: Nixon & Vanderhye, PC

20070128722 - Human mesenchymal stem cells and culturing methods thereof: Provided herein are methods of proliferating human mesenchymal stem cells obtained from human cord blood and/or human bone marrow aspirates comprising culturing the human mesenchymal stem cells in an environment containing extracellular matrix isolated form human fibroblasts.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070128723 - Progenitor endothelial cell capturing with a drug eluting implantable medical device: A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for... Agent: Kelley Drye & Warren LLP

20070128727 - Methods for differentiation of embryonic stem cells: Methods are provided for the in vitro differentiation of one or both of adipocytes and osteoblasts from embryonic stem cells.... Agent: Bozicevic, Field & Francis LLP

20070128725 - Methods of manipulating and sequencing nucleic acid molecules using transposition and recombination: The present invention relates generally to methods, kits and compositions for use in manipulating nucleic acid molecules, particularly cloning, sequencing, amplifying and mutating such molecules. In particular, the invention relates to use of recombination sites and recombinational cloning to manipulate, select and analyze nucleic acid molecules of interest.... Agent: Invitrogen Corporation C/o Intellevate

20070128724 - System for the rapid manipulation of nuculeic acid sequences: The present invention is a cell-free subcloning system utilizing three elements: (1) a donor vector that contains a nucleic acid sequence to be transferred to another vector flanked by a site-specific recombination sequence and one or more optional additional nucleic acid sequences, (2) an acceptor vector that contains a site-specific... Agent: Invitrogen Corporation C/o Intellevate

20070128726 - Transgenomic mitochondria. transmitochondrial cells and organisms, and methods of making and using: The invention provides transgenomic mitochondria, transmitochondrial cells and organisms, and the materials and methods for making such mitochondria, cells, and organisms.... Agent: Eugenia S. Hansen Hemingway & Hansen, LLP

20070128728 - Plasmids and packaging cell lines for use in phage display: The invention relates to a novel phagemid display system for packaging phagemid DNA into phagemid particles which completely avoids the use of helper phage. The system of the invention incorporates the use of bacterial packaging cell lines which have been transformed with helper plasmids containing all required phage proteins but... Agent: Los Alamos National Security, LLC

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