Chemistry: molecular biology and microbiology inventions 05/07

20070122794 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati

20070122795 - Information processing apparatus, information processing method, information processing system, program, and recording medium: Disclosed herein is an information processing apparatus, method, system, and program, and a recording medium. An information processing apparatus includes an acquisition unit, an arithmetic unit, and an output control unit. The acquisition unit acquires the amount of the molecules for detection which have been produced by control cells and... Agent: William S. Frommer, Esq. C/o Frommer Lawrence & Haug LLP

20070122796 - Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same: A basement membrane having a barrier function is formed by culturing alveolar epithelial cells or vascular endothelial cells on a fibrous collagen matrix coated with a polymer having a sugar chain that can localize a receptor that has an activity to accumulate a basement membrane component on the basal surface... Agent: Frommer Lawrence & Haug

20070122797 - System for tracking biological samples: Systems, methods, and apparatus are described for the handling of biological specimens for analysis. The systems, methods and apparatus are designed to reduce errors in misidentification, incorrect processing, and recordkeeping and reporting. The systems, methods, and apparatus can also provide real time tracking of samples at any stage, from collection... Agent: Dako, Global Intellectual Property C/o Thomas F. Cooney

20070122801 - Binding molecules capable of neutralizing west nile virus and uses thereof: The invention provides human binding molecules specifically binding to West Nile virus and having West Nile virus neutralizing activity, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used... Agent: Trask Britt

20070122799 - Method of isolation and self-assembly of small protein particles from blood and other biological materials: Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are misfolded or partially misfolded proteins surrounding a metallic nanocluster, termed “proteon nucleation center” (PNC). Also... Agent: Andrus, Sceales, Starke & Sawall, LLP

20070122798 - Methods and tools for screening active rna in cellulo: The invention relates to methods and compositions for screening active RNA in cellulo. The invention more particularly relates to methods of the preparation and selection of random RNA providing a cell with a desired phenotype, to random RNA banks and the production thereof, as well as to cellular populations which... Agent: Nixon & Vanderhye, PC

20070122800 - Methods for quantifying polymer attachment to a particle: The present invention relates to improved methods for quantifying the degree of polymer attachment of particles with multiple polymer attachment sites. The disclosed methods are useful for gene therapy, particularly gene therapy using pegylated adenoviral vectors.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070122823 - Amniotic fluid cell-free fetal dna fragment size pattern for prenatal diagnosis: The present invention relates to improved methods of prenatal diagnosis, screening, monitoring and/or testing. The inventive methods include analysis of the fragment size distribution of cell-free fetal DNA isolated from amniotic fluid. The inventive methods allow for rapid screening of fetal characteristics such as chromosomal abnormalities and for prenatal diagnosis... Agent: Choate, Hall & Stewart LLP

20070122819 - Analyte assay structure in microfluidic chip for quantitative analysis and method for using the same: The object of the present invention is to provide a sample assay structure in a microfluidic chip for quantitative analysis which comprises a sample inlet port for inputting a testing sample; an analyte detection region, coupled to the sample inlet port, consisting of at least one microfluidic channel, in which... Agent: Bacon & Thomas, PLLC

20070122821 - Antisense composition and method for treating muscle atrophy: A method and compound for treating skeletal muscle mass deficiency in a human subject are disclosed. The composition is an oligomer of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, contains between 10-40 nucleotide bases, has... Agent: Perkins Coie LLP

20070122820 - Balanced translocation in comparative hybridization: The present invention provides comparative genomic hybridization methods for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. The method includes hybridization with one or more probes for detecting balanced translocations.... Agent: Foley & Lardner LLP

20070122834 - Biochip substrate holding method and biochip-reader: The present invention is characterized by the following points: In measurement of a biochip whose substrate is held on a base and samples are spotted onto the sites in an array on the substrate, a biochip substrate holding method, which does not generate deviation of site positions between the arrangement... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20070122810 - Brain tumor marker and method of diagnosing brain tumor: The present invention provides a brain tumor marker, characterized in that the brain tumor marker is at least one protein expressed in a brain tumor tissue and selected from the group of proteins having the amino acid sequences represented by SEQ ID NOS: 1 to 16, respectively, wherein the protein... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070122804 - Combined exponential and linear amplification: Methods and compositions are provided for sensitive detection and quantitation of nucleic acids. Methods and compositions are further provided for genotyping. Probes of the invention allow target initiated amplification for single stranded, double stranded polynucleotides and pyrophosphate (PPi). DNA enzyme mediated detection method is also provided for detecting single stranded... Agent: Merchant & Gould PC

20070122822 - Compositions and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration: Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration in vivo, ex vivo and in vitro are presented. These methods and compositions involve cells and cell-free extracts with altered levels or activities of a protein from the RAD52 epistasis group, the mismatch repair group and/or the excision repair group.... Agent: Mccarter & English, LLP Basil S. Krikelis

20070122811 - Compositions and processes for genotyping single nucleotide polymorphisms: The invention relates to processes, compositions and kits for analysis of nucleic acid variations, especially single nucleotide polymorphisms (SNPs). An inventive process includes a procedure to enzymatically remove inorganic pyrophosphate from a sample prior to and/or during a single base extension reaction. Processes and compositions described herein are especially useful... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

20070122836 - Control of tgfbeta signaling by km23 superfamily members: Methods of identifying therapeutic agents that inhibit, potentiate or mimic the ability of a km23 polypeptide mutant form, or a nucleic acid encoding the mutant form to modulate the signal transduction activity of a growth factor or cytokine are provided. The methods involve treating a cell with a candidate compound... Agent: Hoffmann & Baron, LLP

20070122831 - Detection and source identification of microbial contaminants in water samples: The present invention relates generally to methods of microbial source tracking in environmental water samples. More specifically the present invention relates to methods of microbial source tracking using detection of Bifidobacterium species as markers of source contamination in environmental water samples. The present invention utilizes differences in DNA sequence between... Agent: King & Spalding LLP

20070122829 - Device and method for measuring analytes: The present invention is directed to a system, device and method for measuring the concentration of an analyte in a fluid or matrix. A thermodynamically stabilized analyte binding ligand for use in the system, device and method is disclosed. The thermodynamically stabilized analyte binding ligand is resistant to degradation at... Agent: Winstead Sechrest & Minick P.C.

20070122833 - Enzymatic deposition and alteration of metals: Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally disclosed is how to use enzymes to accumulate metal particles. The alteration of metal particles by enzymes interacting with the organic shell of the particles is... Agent: Wilson Sonsini Goodrich & Rosati

20070122818 - Gene methylation assay controls: Methods, components, and kits for evaluating the effectiveness of methylation assays are presented as are methylation assays that include nucleotide sequence controls and methods of using them.... Agent: Philip S. Johnson Johnson & Johnson

20070122805 - Haplotype analysis: The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic add markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dilutions and the consequent statistical analysis of the results from these... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20070122808 - Measurement of a polynuleotide amplification reaction: A quantitative measurement of the progress of a polynucleotide amplification reaction can be made by: (i) carrying out a reaction for the amplification of a target polynucleotide; (ii) either during or after the amplification reaction contacting the amplified product with a molecule that binds to or interacts with a polynucleotide,... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070122824 - Method and kit for assessing a patient's genetic information, lifestyle and environment conditions, and providing a tailored therapeutic regime: A method of determining a personalised therapeutic regime, comprising: receiving genetic information relating to a patient; determining genetic criteria relevant to a personalised therapeutic regime for the patient using the genetic information; receiving personal information relating to the patient; determining personal criteria relevant to the personalised therapeutic regime using the... Agent: Greenlee Winner And Sullivan P C

20070122812 - Method of screening for protein secretion recombinant host cells: The invention describes a method of screening for protein secreting recombinant host cells comprising screening for promoter activity of a stress inducible promoter. The method can be used for rapid identification of actively secreting transformants and can be used to screen recombinant libraries for transformants secreting proteins.... Agent: Novozymes North America, Inc.

20070122825 - Method to predict the response to lithium treatment: The disclosure provides methods and compositions useful for identifying a subject's predisposition to lithium treatment.... Agent: Buchanan, Ingersoll & Rooney LLP

20070122839 - Methods and compositions for nucleic acid analysis: The present invention relates to improved methods and composition for nucleic acid analysis. In particular, the present invention provides improved methods and compositions for carrying out nucleic acid analysis using modified nucleotides.... Agent: Medlen & Carroll, LLP

20070122838 - Methods and computer software products for identifying transcribed regions of a genome: Methods and computer software products are provided for transcriptional annotation. In one embodiment of the invention, a region of the genome where the intensity of hybridization of all the probes are above a threshold value (usually the level of non-specific hybridization) is identified. The region may be identified by aligning... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070122817 - Methods for assembly of high fidelity synthetic polynucleotides: Disclosed are methods of manufacturing synthetic DNAs, that is, DNAs made at least in significant part by chemical synthesis of polynucleotide polymers. Also provided are methods for assembling plural DNAs in the same pool by multiplexed assembly of synthetic oligonucleotides. In exemplary embodiments, the methods involve pre-amplification of one or... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070122835 - Methods for detection of genetic disorders: The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present... Agent: Morrison & Foerster LLP

20070122814 - Methods for distinguishing prognostically definable aml: Disclosed is a method for distinguishing prognostically definable AML subtypes with normal karyotype into different prognosis subsets in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.... Agent: Clark & Elbing LLP

20070122803 - Methods for the detection of polymorphisms in the human oatpf gene: The invention provides a method for the detection of a polymorphism in OATPF in a human. The method for detection of a nucleic acid polymorphism is selected from amplification refractory mutation system and restriction fragment length polymorphism. The invention also provides use of the method to assess the pharmacogenetics of... Agent: Fish & Richardson P.C.

20070122802 - Methods of diagnosing and treating diabetes and insulin resistance: The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels... Agent: Townsend And Townsend And Crew, LLP

20070122816 - Microarray comprising qc probes and method for fabricating the same: A quality control (QC) probe for inspecting a quality of a microarray, a method for fabricating a microarray in which the QC probe and a target probe are immobilized on a support, and a method for inspecting the quality of a microarray using the QC probe are provided. More particularly,... Agent: Greenlee Winner And Sullivan P C

20070122826 - Minimal bacterial genome: The present invention relates, e.g., to a minimal set of protein-coding genes which provides the information required for replication of a free-living organism in a rich bacterial culture medium, wherein (1) the gene set does not comprise the 101 genes listed in Table 2; and/or wherein (2) the gene set... Agent: Venable LLP

20070122837 - Mothod for the synthesis of dna sequences: A method is disclosed for the direct synthesis of double stranded DNA molecules of a variety of sizes and with any desired sequence. The DNA molecule to be synthesis is logically broken up into smaller overlapping DNA segments. A maskless microarray synthesizer is used to make a DNA microarray on... Agent: Quarles & Brady LLP

20070122809 - Nucleic acid isolation: The invention provides materials and methods for purifying nucleic acids from a biological sample held in a container (30) such as a centrifuge tube. A filtration unit (1) having a filter (7, 9) and a filtrate chamber (5) is placed within the container (30). Preferably the exterior of the filtration... Agent: Vinson & Elkins, L.L.P.

20070122807 - Posh polypeptides, complexes and related methods: The application provides novel complexes of POSH polypeptides and POSH-associated proteins. The application also provides methods and compositions for treating POSH-associated diseases such as neurological disorders.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070122806 - Predicting graft rejection: The present invention features prognostic methods useful in assessing patients who have received a transplant and reagents, optionally packaged as kits or organized as arrays, that can be used to carry out those methods. The inventions are based, in part, on our analysis of gene expression in renal allografts and... Agent: Fish & Richardson PC

20070122832 - Process for preparing l-amino acids: The invention relates to isolated polynucleotides comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20070122830 - Prohibitin-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance: Disclosed are methods for treating neoplastic cells, including reversing or preventing chemotherapeutic drug resistance, by increasing the sensitivity of the neoplastic cells to a chemotherapeutic drug. In addition, methods are further disclosed for diagnosing chemotherapeutic drug resistance in neoplastic cells by detecting an increase in the expression of prohibitin in... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070122828 - Short cycle methods for sequencing polynucleotides: The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion.... Agent: Goodwin Procter LLP Patent Administrator

20070122815 - Solid support for nucleic acid detection: The present invention relates to solid supports for control nucleic acids. The present invention also relates to methods for the manufacture thereof, and methods of use thereof.... Agent: Nixon & Vanderhye, PC

20070122827 - Target nucleic acid signal detection: Provided herein are methods, compositions and kits for detecting a target nucleic acid. A target nucleic acid can be produced, for example, by a cleavage reaction in an assay for detection of biological samples. In one aspect, a described method comprises the following steps: hybridizing the target nucleic acid having... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070122813 - Use of cripto-1 as a biomarker for neurodegenerative disease and method of inhibiting progression thereof: A method of detecting a neurodegenerative disease in a mammal, which method comprises assaying the copy number of a Cripto-1 gene or the expression level of a Cripto-1 gene product in the central nervous system of the mammal, wherein an amplification of the Cripto-1 gene or an overexpression of the... Agent: Leydig, Voit & Mayer, Ltd.

20070122846 - Anti-human mitochondrial adenylate kinase isozyme antibody, diagnostic formulation and diagnostic kit for cardiac disease: The present invention relates to an immunological formulation and a diagnostic kit for cardiac disease using human mitochondrial adenylate kinase isozymes. The present invention provides an immunological formulation and a diagnostic kit for cardiac disease, which are featured by using mitochondrial adenylate kinase isozymes which exist in a myocardiac cell... Agent: Foley And Lardner LLP Suite 500

20070122840 - Assay panel comprising food allergens: There is described a substrate to which is applied, coupled or cross-linked to at least one part of said substrate an allergen wherein said allergen is a protein derived from an extract selected from at least one of the following food groups: cereal, legume, cocoa bean, nut, fruit, vegetable, shellfish,... Agent: Morgan, Lewis & Bockius LLP (sf)

20070122848 - Biochemical reaction cassette and detection apparatus for biochemical reaction cassette: A biochemical reaction cassette comprises: a substrate carrying probes immobilized thereon, the probes being adapted to be specifically bound to a target substance; a reaction space forming member for forming a reaction space with the substrate; an elastic member; and an anchor member for supporting the substrate so as to... Agent: Fitzpatrick Cella Harper & Scinto

20070122843 - Isoflavonoid analogs and their metal complexes as anti-cancer agents: A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal... Agent: Rohm & Monsanto, PLC

20070122841 - Massively parallel synthesis of proteinaceous biomolecules: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly... Agent: Blakely Sokoloff Taylor & Zafman

20070122842 - Massively parallel synthesis of proteinaceous biomolecules: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly... Agent: Blakely Sokoloff Taylor & Zafman

20070122845 - Methods for identifying gpr83 agonists and gpr83 antagonists capable of modulating regulatory t cell function: The present invention provides methods for identifying a GPR83 agonist capable of stimulating a regulatory T cell function and methods for identifying a GPR83 antagonist capable of suppressing a regulatory T cell function.... Agent: Lahive & Cockfield, LLP

20070122847 - Mitochondrial markers of ischemia: Damage to tissue, such as ischemic damage, can cause the release of mitochondrial proteins. The released proteins can be detected in a sample taken from a subject, indicating that the subject has suffered damage.... Agent: Michaud-duffy Group LLP

20070122851 - Novel fluorescent and colored proteins, and polynucleotides that encode these proteins: The subject invention provides new fluorescent and/or colored proteins, and polynucleotide sequences that encode these proteins. The subject invention further provides materials and methods useful for expressing these detectable proteins in biological systems.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070122850 - Reduction of non-specific binding in assays: Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the... Agent: Dade Behring Inc. Legal Department

20070122844 - Reduction of redundant protein identification in high throughput proteomics: There is provided a method for the identification of proteins with reduced redundancy in protein hits. The method eliminates protein hits that are described by peptides sets that are included in at least one other protein hit associated peptides set.... Agent: Bereskin And Parr

20070122849 - Rhesus monkey p2x7 purinergic receptor and uses thereof: A P2X7 purinergic receptor has been isolated from the genome of Macaca mulatta (Rhesus monkey). Described is the amino acid sequence of the receptor, the nucleic acid encoding the receptor, and methods for using the receptor to identify analytes that are agonists or antagonists of the receptor.... Agent: Merck And Co., Inc

20070122852 - Method for identifying antigen specific b cells: The present invention relates to a method of identifying a B cell carrying a surface immunoglobulin molecule having a binding site for an antigen of interest comprising contacting a sample putatively containing said B cell with the antigen of interest wherein said antigen is labeled with a first label and... Agent: Fulbright & Jaworski L.L.P.

20070122853 - Methods and compositions for detecting larval taenia solium with a cloned diagnostic antigen: Compositions and methods for the detection of Taenia solium and the diagnosis of T. solium infection are described. The nucleotide and amino acid sequences of the antigenic T. solium polypeptides gp50a, gp50b and gp50c are provided. The compositions contain synthetic antigenic polypeptides of larval origin prepared using the sequences described... Agent: Klarquist Sparkman, LLP

20070122854 - Method for diagnosing colon cancer: The present invention relates to a method for diagnosing colon cancer by detecting a colon cancer specific antigen, defensin α6 from the blood of patient and a diagnostic kit for colon cancer comprising anti-defensin α6 antibody, The diagnostic kit for colon cancer of present invention comprises, a solid support such... Agent: Darby & Darby P.C.

20070122855 - Methods for diagnosing hepatocellular carcinoma: Methods are provided for hepatocellular carcinoma (HCC) diagnosis. The methods confirm the occurrence of HCC in a subject suspected of suffering from HCC by determining the level of either IL-6 or IL-10 in a plasma sample obtained from the subject. Also provided are methods for distinguishing HCC from other liver... Agent: Akin Gump Strauss Hauer & Feld L.L.P.

20070122856 - Tissue diagnostics for ovarian cancer: Disclosed are methods for diagnosing ovarian cancer in a cell sample by detecting an increase in the levels of expression of protein markers in the cell sample as compared to the levels of expression of the same protein markers in a normal, nonneoplastic ovarian cell sample. Also disclosed is a... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070122857 - Antibodies specific to antigens of bartonella henselae and use of these antigens in immunoassays: Disclosed are antibodies that bind to the antigenic proteins GroES, RplL, GroEL, SodB, UbiG, the ABC transporter, and an expressed antigenic protein of unknown function (the “BepA” protein) of Bartonella henselae, and use of these antigenic proteins in immunoassays in order to determine whether a sample from a subject contains... Agent: Medical Diagnostic Laboratories LLC

20070122858 - Cell-based fluorescence resonance energy transfer (fret) assays for clostridial toxins: The present invention provides a method of determining clostridial toxin activity by (a) contacting with a sample a cell containing a clostridial toxin substrate that includes a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence containing... Agent: Allergan, Inc.

20070122859 - Immunoassay for lsd and 2-oxo-3-hydroxy-lsd: The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indole nitrogen to form an aminoalkyl derivative. The resulting haptens... Agent: Roche Diagnostics Operations Inc.

20070122860 - Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions... Agent: Medlen & Carroll, LLP

20070122861 - Cross-reactive sensors: The present invention provides a novel cross-reactive sensor system utilizing cross-reactive recognition elements. In the inventive system, each of said one or more cross-reactive recognition elements is capable of interacting with more than one species of liquid analyte of interest, whereby each of said one or more cross-reactive recognition elements... Agent: Sam Pasternak Choate Hall & Stewart

20070122863 - Methods and means for the detection of enzyme-catalyzed cleavage and linking reactions: The invention relates to methods and means for the detection of enzyme-catalyzed cleavage and linking reactions. Modular chemical compounds which serve as substrates for the enzymes involved are provided. The detection of the reaction products is effected by means of molecular-weight-sensitive methods.... Agent: Jacobson Holman PLLC

20070122862 - Screening for lipolytic enzymes or amidase activity: A method of testing samples for their enzymatic activity for hydrolysis of a particular ester or amide bond in a substrate uses a test substrate with one or more polyunsaturated fatty acyl groups linked through amide or ester bonds. The release of the polyunsaturated fatty acid is detected by the... Agent: Novozymes North America, Inc.

20070122864 - Methods for the determination of protein three-dimensional structure employing hydrogen exchange analysis to refine computational structure prediction: The present invention provides methods of structure prediction and/or determination of a protein of interest of unknown structure. Invention methods compare calculated rates of amide hydrogen exchange for a set of predicted possible structures for said protein with experimental hydrogen exchange analysis of said protein to identify valid protein structures... Agent: Foley & Lardner LLP

20070122865 - Enzymes and enzymic processes: A chimeric protein comprises a haem domain from a mammalian or plant cytochrome P450 and a scaffold domain generally comprising an electron transfer domain, from P450 BM3 of Bacillus megaterium. The protein does not include the membrane binding portion of the wild type mammalian or plant P450 and is hence... Agent: Sughrue Mion, PLLC

20070122866 - Protein having pge2 synthase activity and use thereof: A single protein which is the substance of the PGE2 synthesis activity in brain soluble fractions of LPS administered rats has been purified and identified. The protein has an activity of synthesizing PGE2 from PGH2, and further, has an activity of synthesizing PGE2 from arachidonic acid in combination with COX.... Agent: Fish & Richardson PC

20070122867 - Medical device for monitoring blood phenylalanine levels: A medical device adapted for the monitoring of blood levels of phenylalanine utilizing colormetric analysis, comprising a unit containing testing elements, or insertion means for receiving a substrate having a test biological sample thereon and a means on said device for displaying a test result for a level of phenylalanine... Agent: Greenberg Traurig, LLP

20070122868 - Gene 763 of phytopathogenic fungus magnaporthe grisea and use thereof for identifying fungicidal compounds: The invention concerns a novel nucleic acid fragment of the genome of rice pathogenic fungus Magnaporthe grisea comprising a gene coding for a protein (hereafter referred to as gene 763) whereof the presence and integrity are indispensable for pathogenesis of said fungus with respect to rice and barley. The invention... Agent: Connolly Bove Lodge & Hutz, LLP

20070122872 - Method for storage of clinical samples prior to culture: The present invention provides a storage media for the storage and transport of clinical samples. The storage medium comprises a microbiological growth medium, glycerol and a reducing agent. Clinical samples, such as sputum, can be added to the storage medium at the point of collection and then transported in the... Agent: Hodgson Russ LLP

20070122870 - Method for water testing and devices and kit of components for use in such a method: A method for the determination of water quality, which method comprises: contacting a vessel comprising a population of bacteria with a water sample to be tested, said vessel comprising a semi-permeable material which allows the water sample to pass therethrough and contact said bacteria; and determining the growth rate of... Agent: Nixon & Vanderhye, PC

20070122871 - Microbial strains producing sphingosine: The present invention provides a process to identify microorganisms that are capable of converting exogenous phytosphingosine into sphingosine. The microorganism possess a dehydratase activity. The process comprises the steps of providing a series of candidate microorganisms, incubating said series of candidate microorganisms in the presence of a suitable amount of... Agent: Oliff & Berridge, PLC

20070122869 - Organism-culture apparatus and culture method: An organism-culture apparatus, which can be conveniently prepared, can be stored for a long period, can be efficiently handled, and can be adapted to various organisms and culture conditions without restricting a kind of an organism to be cultured or the culture condition, and can be recycled after sterilization and... Agent: Birch Stewart Kolasch & Birch

20070122873 - Signal amplification using a synthetic zymogen: Described herein are zymogens, methods of use for zymogens, and devices that incorporate zymogens. The zymogens include a substrate and an enzyme. The substrate can inhibit the enzyme and is a target for a protein produced by a microorganism. When the substrate is modified by a protein produced by a... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070122874 - Novel microbial consortium and use thereof for liquefaction of solid organic matter: The present invention relates to a novel process for liquefaction of solid organic matter by biological method. By this process the solid organic matter can be hydrolyzed using anaerobically treated water containing a consortium of fermentative micro-organisms thus resulting in an organic liquid which can be digested easily when applied... Agent: Seed Intellectual Property Law Group PLLC

20070122879 - Cytokine receptor: Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention... Agent: Zymogenetics, Inc. Intellectual Property Department

20070122875 - Enzyme for decomposition of sulfated fucan derived from sea cucumber: Sulfated fucan lyase capable of decomposing sulfated fucan derived from sea cucumber; a process for producing the enzyme; a low molecular compound obtained by causing the enzyme to act on sulfated fucan; a process for producing the same; and an activating factor for sulfated fucan lyase.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070122882 - Gene specifically expressed in postmitotic dopaminergic neuron precursor cells: A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network... Agent: Townsend And Townsend And Crew, LLP

20070122883 - Human cytokine receptor: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”... Agent: Zymogenetics, Inc. Intellectual Property Department

20070122878 - Human orphan g protein-coupled receptors: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.... Agent: Cozen O'connor, P.C.

20070122876 - Nucleic acids for enhancing gene expression and use thereof: The present invention relates to a method for producing a protein, novel nucleic acid fragment, an expression vector, and a method for enhancing the protein production in Pichia. The present invention provides that the combination of the modified signal peptide, increased copy number of the gene, and/or overexpressed Sec4p resulted... Agent: Harness, Dickey & Pierce, P.L.C

20070122881 - Rhamnose-inducible expression systems and methods: Rhamnose-inducible expression constructs are described. The expression constructs may be either episomal or chromosomal and may include at least one rhamnose-inducible regulatory element expressing a regulatory protein and at least one promoter that is inducible by the regulatory protein. An open reading frame expressing a protein of interest may be... Agent: Knobbe Martens Olson & Bear LLP

20070122877 - T-cell vaccination in the treatment of hiv infection: A method for the preparation of a T cell vaccine for the treatment of immunodeficient HIV-infected patients is described herein, based on the enrichment of autologous CD4-reactive CD8 T cells. Also described is a protocol for the implementation of T cell vaccination in immunodeficient HIV-infected, as well as a method... Agent: Frommer Lawrence & Haug

20070122880 - Vector for the inducible expression of gene sequences: The invention relates to a nucleic acid construct that comprises a human EF-1α promoter operatively associated with the tetracycline repressor (TetR). The invention further provides cell lines that have been stably transfected with such construct, as well as methods of using said construct, for the inducible expression of a transgene... Agent: Nixon & Vanderhye, PC

20070122884 - Factor vii glycoforms: The present invention provides preparations of Factor VIIa polypeptides or Factor VIIa-related polypeptides that exhibit predetermined glycoform patterns. The preparations of the invention exhibit improved functional properties and are useful for treating Factor VII-mediated conditions.... Agent: Novo Nordisk, Inc. Patent Department

20070122885 - Methods of increasing production of secondary metabolites by manipulating metabolic pathways that include methylmalonyl-coa: A process of increasing the cellular production of secondary metabolites, such as antibiotics, is provided. The process is particularly useful for increasing antibiotic production by bacterial cells, especially erythromycin. The process includes the step of increasing the activity of methylmalonyl-CoA mutase.... Agent: Dykema Gossett PLLC

20070122886 - Cellulose production by facultatively anaerobic microorganisms: A method for producing bacterial cellulose, said method comprising culturing a biologically pure culture of a cellulose-producing Proteus strain in a liquid medium suitable for culturing facultatively anaerobic microorganisms, separating bacterial cellulose produced in said liquid medium from said liquid medium, washing said separated bacterial cellulose and drying said bacterial... Agent: Daniel R. Polonenko Fasken Martineau Dumoulin LLP

20070122887 - Gene variants coding for proteins from the metabolic pathway of fine chemicals: The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing said genetically modified organisms and to said genetically modified organisms themselves.... Agent: Lahive & Cockfield, LLP

20070122888 - Method for the production of methionine: The present invention relates to a process for producing methionine by fermentation, a process for isolating the methionine formed, the methionine-containing biomass produced in isolation, use thereof for producing a feedstuff or feed supplement, and also to the use of the isolated methionine for producing foodstuffs or feedstuffs or food... Agent: Connolly Bove Lodge & Hutz, LLP

20070122890 - Microorganism of corynebacterium genus having enhanced l-lysine production ability and method of producing l-lysine using the same: Provided are a microorganism of Corynebacterium genus that has an inactivated endogenous NCgl1835 gene therein and produces L-lysine, and a method of producing L-lysine using the same.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070122889 - Microorganism of corynebacterium genus having resistance to kanamycin and enhanced l-lysine productivity and method of producing l-lysine using the same: Provided are a microorganism of Corynebacterium genus capable of producing L-lysine and resistant to kanamycin, and a method of producing L-lysine using the same.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070122891 - Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.... Agent: Louis J. Wille Bristol-myers Squibb Company

20070122892 - Process for producing succinic acid from sucrose: A process for hydrolyzing sucrose to glucose and fructose using succinic acid is described. The hydrolysate can be used to produce purified glucose and/or fructose or can be used as a carbon source for fermentations to produce various chemicals including succinic acid.... Agent: Ian C. Mcleod Mcleod & Moyne, P.C.

20070122893 - Process for preparing an immobilized enzyme: Provided is a process for preparing an immobilized enzyme, which comprises the steps of immobilizing an enzyme used for decomposing oil & fat on a carrier, by adsorption, without drying, bringing the immobilized enzyme into contact with a fatty acid triglyceride or fatty acid partial glyceride, or mixtures thereof, and... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070122894 - Sterile microbiological nutrient media device and methods of using: The present invention relates to a device for assisting in the preparation of a sterile, microbiological nutrient media of a predetermined concentration. In general, such a device comprises three elements. An outer flexible envelope has a re-sealable opening. This outer envelope is comprised of a material that does not transmit... Agent: Brian D. Voyce

20070122895 - Pichia methanolica secretory signal: Novel Pichia methanolica secretory signal polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods of using are disclosed. Methods of producing large amounts of recombinant proteins by employing DNA constructs having a polypeptide of interest preceded by a novel Pichia methanolica secretory signal sequence.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070122896 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati

20070122897 - Micro device for cell culture: A micro device for cell culture is disclosed, which cooperates with a fluid and includes: a top plate having an inlet port; a orifice plate having a plurality of orifices; a culture plate having a plurality of culture wells and a plurality of injection ports; and a bottom plate having... Agent: Bacon & Thomas, PLLC

20070122898 - Device for forming magnetic well for nanoparticles: A device includes a plurality of structures, each structure including at least one ferromagnetic layer having fringe fields. Fringe fields of the structures interact to form a magnetic well for nanoparticles. This device may be adapted for biosensing, wherein the magnetic well is formed about a probe area.... Agent: Hewlett Packard Company

20070122899 - Target substance analysis apparatus and determination software update method: There is provided a biochemical reaction cassette analysis apparatus capable of automatically updating determination software. A biochemical-reaction-cassette-equipped automatic analysis apparatus having a storage section in which determination software is stored in association with its version information and identification information for identifying the kind of probe on a probe carrier is... Agent: Fitzpatrick Cella Harper & Scinto

20070122900 - Bioscrubber: A bioscrubber for purifying dirty gas has a circulated scrubbing liquid which contains water and microorganisms for degradation of the substances to be separated off from the dirty gas. The gas enters at an inlet, moves through a mass-transfer zone, where it undergoes a phase change from the gas phase... Agent: Lerner Greenberg Stemer LLP

20070122903 - Amniotic fluid derived cells: This invention relates to an expandable population of amniotic fluid-derived cells that can be differentiated into a β-cell lineage. This invention also provides methods for isolating and expanding such amniotic fluid-derived cells, as well as related methods and compositions for utilizing such cells in the therapeutic treatment of diabetes.... Agent: Philip S. Johnson Johnson & Johnson

20070122904 - Method and apparatus for culturing cells: A method for culturing cells, the method comprising: providing a plurality of cellulose hollow fibre capillaries having cells and at least one protein required for proliferation, differentiation and/or genetic modification of the cells therein and optionally at least one metabolite; and providing on the extracapillary side of the semi-permeable substrate... Agent: Nixon & Vanderhye, PC

20070122902 - Method for isolating and culturing multipotent progenitor/stem cells from umbilical cord blood and method for inducing differentiation thereof: Since the multipotent progenitor/stem cells isolated and cultured from the cord blood-derived mononuclear cells according to the method of the present invention are capable of differentiating into several types of cells including neurons, osteoblasts, myoblasts, endothelial cells, hepatocytes and dendritic cells, they can be effectively used for a cell therapy,... Agent: Sughrue Mion, PLLC

20070122901 - Method of constructing artificial cell tissue and base material therefor: The present invention relates to a method for culturing cells, which comprises the steps of: causing cells to adhere to the surface of a cell array substrate having a cell adhesiveness variation pattern that comprises regions having good cell adhesiveness and regions having inhibited cell adhesiveness patterned on a substrate;... Agent: Sughrue Mion, PLLC

20070122905 - Pdx1-expressing dorsal and ventral foregut endoderm: Disclosed herein are cell cultures comprising dorsal and/or ventral PDX1-positive foregut endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified dorsal and/or ventral PDX1-positive foregut endoderm cells as well as methods for enriching, isolating and purifying dorsal and/or ventral PDX1-positive foregut endoderm... Agent: Knobbe Martens Olson & Bear LLP

20070122906 - Method of culturing cells: A blood component such as platelets are concentrated from the blood. The concentrate such as platelet-rich plasma is used in a cell culture medium to grow and proliferate cells. The cells may be from the same person from which the blood concentrate is obtained. The cells grown in the culture... Agent: Knobbe Martens Olson & Bear LLP

20070122907 - Orchid culturing method: The invention describes a method to increase the number of inflorescences and/or minimise the need for a cold period for the induction of an inflorescence in an orchid by administration of a cytokinin, preferably 6-BAP, to said orchid, preferably wherein said orchid has a monopodial growth, more preferably wherein said... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20070122908 - Molecular delivery to cells using aspirin-related compounds: The present invention provides for a system and method whereby aspirin and acetic acid help to permeabilize cell membranes to allow exogenous molecules to gain access to the cell interior. As such, the present invention provides a low cost drug and gene delivery tool that can be applied in combination... Agent: Smith Hopen, Pa

20070117085 - Method and device for culturing live cells by coupling a bioreactor receiver with a selection automation: The invention relates to a method for continuously, semi-continuously or discontinuously treating a substrate (24) consisting in placing said substrate in a bioreactor receiver (1) and in exposing it to the action of a living cell culture (C1) which makes it possible to carry out a reaction (R1) on the... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070117086 - Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm: A flow cytometry system (1) for sorting haploid cells, specifically irradiatable sperm cells, with an intermittingly punctuated radiation emitter (56). Embodiments include a beam manipulator (21) and even split radiation beams directed to multiple nozzles (5). Differentiation of sperm characteristics with increased resolution may efficiently allow differentiated sperm cells to... Agent: Santangelo Law Offices, P.C.

20070117087 - Method of providing readily available cellular material derived from peripheral blood, and a compositoin thereof: Method of researching disease states using TVEMF-expanded cells.... Agent: Ladas & Parry LLP

20070117088 - Methods and kits for detection of prion diseases: The invention relates to diagnostic methods and kits for detecting transmissible spongiform encephalopathies (TSEs) such as BSE, scrapie, chronic wasting disease and related diseases in animals and humans. The invention provides a method for determining whether an aberrant prion protein is present or absent in a mammalian sample comprising the... Agent: Ladas & Parry

20070117089 - Sol-gel coated glass microspheres for use in bioassay: A microsphere for use in a bioassay comprising a glass core coated with a sol-gel comprising a bioactive probe is provided. The sol-gel coating enhances the density of bioprobe loading on the surface of the microspheres, resulting in enhanced dynamic range and sensitivity in bioassays. The particle may be used... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070117098 - 'signalin' family of tgfbeta signal transduction proteins and uses related thereto: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here signalin-related genes, which are involved in a signal transduction induced by members of the TGFβ superfamily. The present invention makes available compositions and methods that can be utilized, for example to generate and/or... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070117124 - Achaete-scute like-2 polypeptides and encoding nucleic acids and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Genentech, Inc.

20070117146 - Allelic variants of gpr50: The present invention provides isolated polynucleotides encoding a receptor gene called GPR50 having at least one polymorphic sites. It furthermore provides a method for analyzing polymorphic sites in the receptor gene. Certain of these polynucleotides having a polymorphic site (allelic variants) are found to be more prevelant in a population... Agent: Akzo Nobel Inc.

20070117091 - Anti-candida agents for the treatment of prion diseases: The invention provides methods of treatment of prion disease, cancers and other conditions, the methods comprising administration of an anti-Candida agent. Also disclosed are methods of diagnosing prion disease and cancers, said methods based on the determination of the presence of Candida infection, in particular systemic candidiasis.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070117129 - Antigen arrays for treatment of bone disease: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070117143 - Atm related kinase atx, nucleic acids encoding same and methods of use: The invention provides an isolated nucleic acid molecule having substantially the same nucleotide sequence as SEQ ID NO:1. Also provided is an isolated oligonucleotide having at least 15 contiguous nucleotides of a nucleotide sequence referenced as SEQ ID NO:11. An isolated polypeptide having substantially the same amino acid sequence as... Agent: Mcdermott, Will & Emery

20070117100 - Biomarker for determining predisposition and/or prognosis of hepatocellular carcinoma: Disclosed herein are a method for determining predisposition to hepatocellular carcinoma (HCC) in a subject having or suspected to have a hepatic nodule, in particular one infected with at least one of hepatitis B virus and hepatitis C virus, and a method for prognostic evaluation of a subject having or... Agent: Paul D. Greeley, Esq. Ohlandt, Greeley, Ruggiero & Perle, L.L.P.

20070117119 - Carriers having biological substance: The present invention relates to biological substance-immobilized fibers wherein a biological substance is immobilized on a fiber, fibers retaining a biological substance-immobilized gel, and fiber alignments having bundles of the above-described fibers and slices of the same.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070117121 - Cdna library preparation: New biochemical protocols for high throughput processing of mRNA samples into cDNA libraries with adaptor sequences compatible with automated sequencing systems are provided. The provided methods produces cDNA libraries which do not have 3′ bias associated with current cDNA library production methods. New methods for the production of DNA libraries... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20070117101 - Cleavable oligonucleotide arrays: Oligonucleotide arrays having features that include cleavable oligonucleotides are disclosed, as well as methods of making such arrays. Methods of synthesizing an oligonucleotide on a surface of a substrate are described.... Agent: Agilent Technologies Inc.

20070117114 - Compositions and methods for increasing amplification efficiency: Compositions and methods are provided that improve the specificity and efficiency of nucleic acid amplification. A binding partner may be bound to a DNA polymerase enzyme where the binding partner substantially inhibits the activity of the polymerase. A second enzyme modifies the binding partner in a manner that relieves the... Agent: Proskauer Rose LLP

20070117127 - Cross-species nucleic acid probes: The present invention features a collection of at least four nucleic acid probes. The probes each comprises a segment, the entirety of which hybridizes under low stringency conditions to at least a first gene of a first species and a second gene of a second species, wherein the hybridizing probes... Agent: Fish & Richardson PC

20070117136 - Detection of microsatellite instability and its use in diagnosis of tumors: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to... Agent: Michael Best & Friedrich, LLP

20070117108 - Detection system for pcr assay: The present invention provides a detection system for a PCR process using FRET which comprises at least two single-labelled Oligonucleotide sequences of differing Tm that hybridise to one another in free solution to form a fluorescent quenched pair, that upon introduction of a complementary sequence to one or both sequences... Agent: Bradley N. Ruben, PC

20070117095 - Diagnostic method for neonatal or infantile epilepsy syndromes: A method for the diagnosis of a neonatal or infantile epilepsy syndrome as BFNIS in a patient comprising testing for the presence of an alteration in the SCN2A gene, including in a regulatory region of the gene, in a patient sample, and establishing a diagnosis which will indicate a high... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20070117115 - Discrimination method of target base in dna, and allele specific primer used in the method of the same: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one... Agent: Mcdermott Will & Emery LLP

20070117116 - Discrimination method of target base in dna, and allele specific primer used in the method of the same: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one... Agent: Mcdermott Will & Emery LLP

20070117117 - Discrimination method of target base in dna, and allele specific primer used in the method of the same: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one... Agent: Mcdermott Will & Emery LLP

20070117118 - Discrimination method of target base in dna, and allele specific primer used in the method of the same: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one... Agent: Mcdermott Will & Emery LLP

20070117092 - Dna analysis system: A DNA analysis system 10 includes a thermal cycler 12 operable as an extraction stage for extracting DNA from a sample to be tested and an as amplification stage for replicating identically a region of interest in DNA strands extracted from the sample. A predetermined proteinase is used in the... Agent: Hogan & Hartson LLPIPGroup, Columbia Square

20070117110 - Flow cytometric detection method for dna samples: Disclosed herein are two methods for rapid multiplex analysis to determine the presence and identity of target DNA sequences within a DNA sample. Both methods use reporting DNA sequences, e.g., modified conventional Taqman® probes, to combine multiplex PCR amplification with microsphere-based hybridization using flow cytometry means of detection. Real-time PCR... Agent: John H. Lee Assistant Laboratory Counsel

20070117093 - Heavymethyl assay for the methylation analysis of the gstpi gene: Described herein is a method for the detection of cyto-sine methylation in DNA samples, wherein the following steps are conducted: a genomic DNA sample, which comprises the DNA to be investigated as well as background DNA is treated with bisulfite (= disulfite, hydrogen sulfite) in such a way that all... Agent: Kriegsman & Kriegsman

20070117141 - Identification and cloning of a full-length human clnk-related gene, mist (mast cell immunoreceptor signal transducer): The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or... Agent: Louis J. Wille Bristol-myers Squibb Company

20070117106 - Identification and/or quantification method of nucleotide sequence (s) elements specific of genetically modified plants on arrays: The present invention is related to an identification and/or quantification method of several organisms among many other ones possibly present in the analyzed sample having homologous sequence(s) by the determination of the genetic map of the organism. The method combines a limited number of amplifications of target sequence(s) using common... Agent: Knobbe Martens Olson & Bear LLP

20070117105 - Interferon assay: The present invention relates to methods and reporter cell assays for determining the ability of a patient sample to induce interferon target gene expression in interferon responsive cells. These methods will be useful for detecting, diagnosing, and monitoring those who have or are at risk of various autoimmune disorders or... Agent: Darby & Darby P.C.

20070117145 - Interferon-alpha induced genes: The present disclosure relates to identification of previously known genes as being genes upregulated by interferon-α administration, in particular the human genes corresponding to the cDNA sequence in GenBank designated g4758303, g5453897, g4505186, g2366751, g33917, g4504962, g3978516, g5924396, g4505656, g1504007, g3702446, g4001802, g292289, g4557226, g4507646 and g4507170. Determination of expression... Agent: Alston & Bird LLP

20070117112 - Materials and methods for the generation of fully 2'-modified nucleic acid transcripts: Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070117134 - Method for detection and quantification of t-cell receptor vbeta repertoire: The invention is a method for detecting and measuring T-cell receptor (TCR) repertoires from mammalian lymphocytes. The method is based on the use of the multiple sets of unique primers to amplify 22 regions of the TCR Vβ region and thereby detect clonal expansions related to antigen stimulation of the... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070117140 - Method for selecting antimicrobial agent and utilization thereof: The present invention provides for a method for selecting an antimicrobial agent, which comprises a microbe analyzing step in which microbes in the microbial biota of a sample are analyzed based on base sequence of DNA and an antimicrobial agent selecting step comprising performing search in a data base storing... Agent: Flynn Thiel Boutell & Tanis, P.C.

20070117137 - Method for the determination of a nucleic acid using a control: The present invention is directed to a method for the determination of a target nucleic acid using a special control nucleic acid, a method for the amplification of a partial sequence of said target nucleic acid using primers, a special control and a kit containing said control. The sequence of... Agent: Townsend And Townsend And Crew, LLP

20070117125 - Method of detecting specific fragments of dna or rna with the aid of a real-time polymerase chain reaction: Methods of amplifying specific fragments of DNA or RNA with the aid of a polymerase chain reaction in real time are disclosed. The methods include providing a first oligonucleotide primer that comprises a donor fluorescent dye and a second oligonucleotide primer that comprises an acceptor fluorescent dye; allowing the primers... Agent: Fish & Richardson PC

20070117135 - Method of inoculation for evaluating candidate therapies for prevention of acquisition of infectious diseases: A method of inoculating the vestibular region of the nares with virus, bacteria, fungus, or mold to ascertain whether acquisition and/or prevention of transmission of infection may occur.... Agent: Robert M. Downey, P.A.

20070117139 - Method of manufacturing probe carrier: A flat plate-shaped probe carrier for carrying probes such as single stranded DNAs, proteins, etc., which are reactive specifically with target substances comprises a plurality of ring bodies arranged substantially in parallel and the external space among the ring bodies is filled with a filler such that the openings of... Agent: Fitzpatrick Cella Harper & Scinto

20070117107 - Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance: Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome function. The compositions and methods of... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070117122 - Methods of diagnosing or prognosticating age-related macular degeneration: A method for diagnosing or prognosticating age-related macular degeneration in a subject, or determining whether a subject is at increased risk of developing age-related macular degeneration or monitoring the progression of age-related macular degeneration in a subject, comprising: determining a level, or an activity, or both said level and said... Agent: Jacobson Holman PLLC

20070117111 - Microfabricated reactor, process for manufacturing the reactor, and method of amplification: An integrated microfabricated instrument for manipulation, reaction and detection of microliter to picoliter samples. The instrument is suited for biochemical reactions, particularly DNA-based reactions such as the polymerase chain reaction, that require thermal cycling since the inherently small size of the instrument facilitates rapid cycle times. The integrated nature of... Agent: Cooley Godward LLP The Bowen Building

20070117120 - Mycoplasma detection method and composition: A method of detecting the presence of mycoplasma in a sample and a mycoplasm detection kit. A sample is contacted with a first and a second oligonucleotide probe, wherein the first and second oligonucleotide probes are substantially complementary to portions of a 16S ribosomal subunit of at least one mycoplasma... Agent: Intellectual Property Group Fredrikson & Byron, P.A.

20070117109 - Nanostructures, methods of making and using the same: The disclosure relates to methods and composition for generating nanoscale devices, systems, and enzyme factories based upon a nucleic acid nanostructure the can be designed to have a predetermined structure.... Agent: Buchanan, Ingersoll & Rooney LLP

20070117130 - Novel activin receptor and uses thereof: The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also... Agent: Amgen Inc. Law Department

20070117097 - Novel proteins and novel genes encoding the same: Novel proteins, novel genes encoding the same, plasmids respectively comprising these genes, transformants respectively comprising these plasmids, antibodies or fragments thereof against the above novel proteins, methods of detecting a bacterial infection, and novel polynucleotides are disclosed. The novel proteins are activated human macrophage-specific proteins.... Agent: Darby & Darby P.C.

20070117113 - Nucleic acid fragment encoding an nrps for the biosynthesis of anthramycin: Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin from Streptomyces refuineus subsp. thermotolerans. The genes and proteins allow direct manipulation of benzodiazepines and related chemical structures via chemical engineering of the enzymes involved in... Agent: Sughrue Mion, PLLC

20070117102 - Nucleotide analogs: The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.... Agent: Goodwin Procter LLP Patent Administrator

20070117103 - Nucleotide analogs: The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.... Agent: Goodwin Procter LLP Patent Administrator

20070117104 - Nucleotide analogs: The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.... Agent: Goodwin Procter LLP Patent Administrator

20070117144 - Oligonucleotides useful for detecting and analyzing nucleic acids of interest: The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and detecting mutations, deletions, or duplications of particular exons or other splice variants, e.g., alterations associated with a disease such as cancer, in a nucleic acid sample, e.g., a... Agent: Clark & Elbing LLP

20070117096 - Oscillating temperature capillary electrophoresis and uses therefor: Methods for separating biomolecules using oscillating temperature electrophoresis are disclosed. Uses for such methods are also disclosed including high throughput screening, estimation of allele frequencies, identification of polymorphisms, and separation of DNA molecules.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070117099 - Process and apparatus for combinatorial synthesis: Apparatus and methods are described for split synthesis combinatorial chemistry that provides candidate libraries where an even distribution of theoretical products is obtainable through even mixing during the pooling step, followed by controlled redistribution of the mixed pooled products from the prior addition step into separate synthesis columns, one for... Agent: Wong, Cabello, Lutsch, Rutherford & Brucculeri, L.L.P.

20070117131 - Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process: Novel processes for the replication of influenza viruses in cell culture, and vaccines and diagnostic compositions which contain the influenza viruses obtainable by the process or constituents thereof, are described.... Agent: Novartis Vaccines And Diagnostics Inc.

20070117090 - Processing nucleic acid: The present invention relates to a method of processing nucleic acid. More particularly, it relates to a method of purifying extra-chromosomal DNA by removing cell debris and/or RNA from a process stream comprising extra chromosomal DNA and a precipitate resulting from preceding cell lysis and/or precipitation reactions. It also relates... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20070117128 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG (SEQ ID NO: 37) meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070117142 - Regulation of novel human asparagine-hydroxylases: Reagents that regulate human asparagine-hydroxylase and reagents which bind to human asparagine-hydroxylase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to cardiovascular disorders, anaemia, cancer, inflammatory diseases, fibrotic disorders, and CNS disorders.... Agent: Jeffrey M. Greenman

20070117123 - Salivary protein and rna for breast cancer detection: The present invention provides for the first time the identification of salivary protein and RNA factors that are elevated in breast cancer. The present invention therefore provides methods of diagnosing and providing a prognosis for breast cancer, by examining cancer antigens (protein and RNA) in saliva.... Agent: Townsend And Townsend And Crew, LLP

20070117126 - Shotgun scanning: A combinatorial method that uses statistics and DNA sequence analysis rapidly assesses the functional and structural importance of individual protein side chains to binding interactions. This general method, termed “shotgun scanning”, enables the rapid mapping of functional protein and peptide epitopes and is suitable for high throughput proteomics.... Agent: Merchant & Gould PC

20070117133 - Sparc and methods of use thereof: The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of... Agent: Leydig Voit & Mayer, Ltd

20070117138 - Splice variant cannabinoid receptor (cb1b): The invention is based on the identification of a novel splice variant of human cannabinoid 1 (CB1) receptor, termed CB1b, and its use in the identification of therapeutic agents and in the diagnosis, prevention and treatment of CB associated disorders such as obesity, psychiatric, pain and neurological disorders.... Agent: Astrazeneca R&d Boston

20070117094 - Support, printed material and reagent kit having enzyme fixed thereon, method for preparing the support, method of storing enzyme and method for restoration enzymes: The invention enables enzymes to be stored in a simple manner. Disclosed are a support having an enzyme and a protecting agent for the enzyme fixed thereon; a printed material and a reagent kit comprising the support; a method for preparing the support; a method for restoring the enzyme fixed... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070117132 - System and method for analyzing dependence between gene expressions: An amplification-like, unidirectional dependence between expression levels in gene pairs is identified through statistical analysis including a determination of whether there is a specified level of independence (or non-correlation) between X and Z, where X is a random variable representing the expression level of a first gene, Y is a... Agent: Blank Rome LLP

20070117152 - Biosensor: An object of the present invention is to provide a biosensor that is capable of immobilizing large quantities of physiologically active substances thereon. The present invention provides a biosensor comprising a substrate having on its surface a polysaccharide capable of chemically immobilizing physiologically active substances, wherein the polysaccharide is a... Agent: Sughrue Mion, PLLC

20070117147 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070117148 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070117149 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070117150 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070117154 - Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery: where part (T) is a —Y-L-Z- radical where in Y is CH2or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation... Agent: Myers Bigel Sibley & Sajovec

20070117155 - Histamine receptor: The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070117151 - Method and apparatus for detecting an analyte: A method for determining a concentration of an analyte is provided. The method includes providing a substrate including a conductive region and a recognition layer where the conductive region has a first surface operatively coupled with the recognition layer; The method also includes contacting the substrate with the sample to... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070117156 - Method of detecting native probnp: The present invention relates to antibodies specifically binding to native p