Chemistry: molecular biology and microbiology inventions 05/07

20070122794 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati

20070122795 - Information processing apparatus, information processing method, information processing system, program, and recording medium: Disclosed herein is an information processing apparatus, method, system, and program, and a recording medium. An information processing apparatus includes an acquisition unit, an arithmetic unit, and an output control unit. The acquisition unit acquires the amount of the molecules for detection which have been produced by control cells and... Agent: William S. Frommer, Esq. C/o Frommer Lawrence & Haug LLP

20070122796 - Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same: A basement membrane having a barrier function is formed by culturing alveolar epithelial cells or vascular endothelial cells on a fibrous collagen matrix coated with a polymer having a sugar chain that can localize a receptor that has an activity to accumulate a basement membrane component on the basal surface... Agent: Frommer Lawrence & Haug

20070122797 - System for tracking biological samples: Systems, methods, and apparatus are described for the handling of biological specimens for analysis. The systems, methods and apparatus are designed to reduce errors in misidentification, incorrect processing, and recordkeeping and reporting. The systems, methods, and apparatus can also provide real time tracking of samples at any stage, from collection... Agent: Dako, Global Intellectual Property C/o Thomas F. Cooney

20070122801 - Binding molecules capable of neutralizing west nile virus and uses thereof: The invention provides human binding molecules specifically binding to West Nile virus and having West Nile virus neutralizing activity, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used... Agent: Trask Britt

20070122799 - Method of isolation and self-assembly of small protein particles from blood and other biological materials: Compositions and methods for the isolation and manipulation of misfolded, or partially misfolded, proteins present in blood and other biological materials are provided. In one aspect of the invention, the compositions, hereinafter termed “proteons” are misfolded or partially misfolded proteins surrounding a metallic nanocluster, termed “proteon nucleation center” (PNC). Also... Agent: Andrus, Sceales, Starke & Sawall, LLP

20070122798 - Methods and tools for screening active rna in cellulo: The invention relates to methods and compositions for screening active RNA in cellulo. The invention more particularly relates to methods of the preparation and selection of random RNA providing a cell with a desired phenotype, to random RNA banks and the production thereof, as well as to cellular populations which... Agent: Nixon & Vanderhye, PC

20070122800 - Methods for quantifying polymer attachment to a particle: The present invention relates to improved methods for quantifying the degree of polymer attachment of particles with multiple polymer attachment sites. The disclosed methods are useful for gene therapy, particularly gene therapy using pegylated adenoviral vectors.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070122823 - Amniotic fluid cell-free fetal dna fragment size pattern for prenatal diagnosis: The present invention relates to improved methods of prenatal diagnosis, screening, monitoring and/or testing. The inventive methods include analysis of the fragment size distribution of cell-free fetal DNA isolated from amniotic fluid. The inventive methods allow for rapid screening of fetal characteristics such as chromosomal abnormalities and for prenatal diagnosis... Agent: Choate, Hall & Stewart LLP

20070122819 - Analyte assay structure in microfluidic chip for quantitative analysis and method for using the same: The object of the present invention is to provide a sample assay structure in a microfluidic chip for quantitative analysis which comprises a sample inlet port for inputting a testing sample; an analyte detection region, coupled to the sample inlet port, consisting of at least one microfluidic channel, in which... Agent: Bacon & Thomas, PLLC

20070122821 - Antisense composition and method for treating muscle atrophy: A method and compound for treating skeletal muscle mass deficiency in a human subject are disclosed. The composition is an oligomer of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′ exocyclic carbon of an adjacent subunit, contains between 10-40 nucleotide bases, has... Agent: Perkins Coie LLP

20070122820 - Balanced translocation in comparative hybridization: The present invention provides comparative genomic hybridization methods for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. The method includes hybridization with one or more probes for detecting balanced translocations.... Agent: Foley & Lardner LLP

20070122834 - Biochip substrate holding method and biochip-reader: The present invention is characterized by the following points: In measurement of a biochip whose substrate is held on a base and samples are spotted onto the sites in an array on the substrate, a biochip substrate holding method, which does not generate deviation of site positions between the arrangement... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20070122810 - Brain tumor marker and method of diagnosing brain tumor: The present invention provides a brain tumor marker, characterized in that the brain tumor marker is at least one protein expressed in a brain tumor tissue and selected from the group of proteins having the amino acid sequences represented by SEQ ID NOS: 1 to 16, respectively, wherein the protein... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070122804 - Combined exponential and linear amplification: Methods and compositions are provided for sensitive detection and quantitation of nucleic acids. Methods and compositions are further provided for genotyping. Probes of the invention allow target initiated amplification for single stranded, double stranded polynucleotides and pyrophosphate (PPi). DNA enzyme mediated detection method is also provided for detecting single stranded... Agent: Merchant & Gould PC

20070122822 - Compositions and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration: Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration in vivo, ex vivo and in vitro are presented. These methods and compositions involve cells and cell-free extracts with altered levels or activities of a protein from the RAD52 epistasis group, the mismatch repair group and/or the excision repair group.... Agent: Mccarter & English, LLP Basil S. Krikelis

20070122811 - Compositions and processes for genotyping single nucleotide polymorphisms: The invention relates to processes, compositions and kits for analysis of nucleic acid variations, especially single nucleotide polymorphisms (SNPs). An inventive process includes a procedure to enzymatically remove inorganic pyrophosphate from a sample prior to and/or during a single base extension reaction. Processes and compositions described herein are especially useful... Agent: Gifford, Krass, Sprinkle, Anderson & Citkowski, P.C.

20070122836 - Control of tgfbeta signaling by km23 superfamily members: Methods of identifying therapeutic agents that inhibit, potentiate or mimic the ability of a km23 polypeptide mutant form, or a nucleic acid encoding the mutant form to modulate the signal transduction activity of a growth factor or cytokine are provided. The methods involve treating a cell with a candidate compound... Agent: Hoffmann & Baron, LLP

20070122831 - Detection and source identification of microbial contaminants in water samples: The present invention relates generally to methods of microbial source tracking in environmental water samples. More specifically the present invention relates to methods of microbial source tracking using detection of Bifidobacterium species as markers of source contamination in environmental water samples. The present invention utilizes differences in DNA sequence between... Agent: King & Spalding LLP

20070122829 - Device and method for measuring analytes: The present invention is directed to a system, device and method for measuring the concentration of an analyte in a fluid or matrix. A thermodynamically stabilized analyte binding ligand for use in the system, device and method is disclosed. The thermodynamically stabilized analyte binding ligand is resistant to degradation at... Agent: Winstead Sechrest & Minick P.C.

20070122833 - Enzymatic deposition and alteration of metals: Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally disclosed is how to use enzymes to accumulate metal particles. The alteration of metal particles by enzymes interacting with the organic shell of the particles is... Agent: Wilson Sonsini Goodrich & Rosati

20070122818 - Gene methylation assay controls: Methods, components, and kits for evaluating the effectiveness of methylation assays are presented as are methylation assays that include nucleotide sequence controls and methods of using them.... Agent: Philip S. Johnson Johnson & Johnson

20070122805 - Haplotype analysis: The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic add markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dilutions and the consequent statistical analysis of the results from these... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20070122808 - Measurement of a polynuleotide amplification reaction: A quantitative measurement of the progress of a polynucleotide amplification reaction can be made by: (i) carrying out a reaction for the amplification of a target polynucleotide; (ii) either during or after the amplification reaction contacting the amplified product with a molecule that binds to or interacts with a polynucleotide,... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070122824 - Method and kit for assessing a patient's genetic information, lifestyle and environment conditions, and providing a tailored therapeutic regime: A method of determining a personalised therapeutic regime, comprising: receiving genetic information relating to a patient; determining genetic criteria relevant to a personalised therapeutic regime for the patient using the genetic information; receiving personal information relating to the patient; determining personal criteria relevant to the personalised therapeutic regime using the... Agent: Greenlee Winner And Sullivan P C

20070122812 - Method of screening for protein secretion recombinant host cells: The invention describes a method of screening for protein secreting recombinant host cells comprising screening for promoter activity of a stress inducible promoter. The method can be used for rapid identification of actively secreting transformants and can be used to screen recombinant libraries for transformants secreting proteins.... Agent: Novozymes North America, Inc.

20070122825 - Method to predict the response to lithium treatment: The disclosure provides methods and compositions useful for identifying a subject's predisposition to lithium treatment.... Agent: Buchanan, Ingersoll & Rooney LLP

20070122839 - Methods and compositions for nucleic acid analysis: The present invention relates to improved methods and composition for nucleic acid analysis. In particular, the present invention provides improved methods and compositions for carrying out nucleic acid analysis using modified nucleotides.... Agent: Medlen & Carroll, LLP

20070122838 - Methods and computer software products for identifying transcribed regions of a genome: Methods and computer software products are provided for transcriptional annotation. In one embodiment of the invention, a region of the genome where the intensity of hybridization of all the probes are above a threshold value (usually the level of non-specific hybridization) is identified. The region may be identified by aligning... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070122817 - Methods for assembly of high fidelity synthetic polynucleotides: Disclosed are methods of manufacturing synthetic DNAs, that is, DNAs made at least in significant part by chemical synthesis of polynucleotide polymers. Also provided are methods for assembling plural DNAs in the same pool by multiplexed assembly of synthetic oligonucleotides. In exemplary embodiments, the methods involve pre-amplification of one or... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070122835 - Methods for detection of genetic disorders: The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or absence of a chromosomal abnormality. The present... Agent: Morrison & Foerster LLP

20070122814 - Methods for distinguishing prognostically definable aml: Disclosed is a method for distinguishing prognostically definable AML subtypes with normal karyotype into different prognosis subsets in a sample by determining the expression level of markers, as well as a diagnostic kit and an apparatus containing the markers.... Agent: Clark & Elbing LLP

20070122803 - Methods for the detection of polymorphisms in the human oatpf gene: The invention provides a method for the detection of a polymorphism in OATPF in a human. The method for detection of a nucleic acid polymorphism is selected from amplification refractory mutation system and restriction fragment length polymorphism. The invention also provides use of the method to assess the pharmacogenetics of... Agent: Fish & Richardson P.C.

20070122802 - Methods of diagnosing and treating diabetes and insulin resistance: The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels... Agent: Townsend And Townsend And Crew, LLP

20070122816 - Microarray comprising qc probes and method for fabricating the same: A quality control (QC) probe for inspecting a quality of a microarray, a method for fabricating a microarray in which the QC probe and a target probe are immobilized on a support, and a method for inspecting the quality of a microarray using the QC probe are provided. More particularly,... Agent: Greenlee Winner And Sullivan P C

20070122826 - Minimal bacterial genome: The present invention relates, e.g., to a minimal set of protein-coding genes which provides the information required for replication of a free-living organism in a rich bacterial culture medium, wherein (1) the gene set does not comprise the 101 genes listed in Table 2; and/or wherein (2) the gene set... Agent: Venable LLP

20070122837 - Mothod for the synthesis of dna sequences: A method is disclosed for the direct synthesis of double stranded DNA molecules of a variety of sizes and with any desired sequence. The DNA molecule to be synthesis is logically broken up into smaller overlapping DNA segments. A maskless microarray synthesizer is used to make a DNA microarray on... Agent: Quarles & Brady LLP

20070122809 - Nucleic acid isolation: The invention provides materials and methods for purifying nucleic acids from a biological sample held in a container (30) such as a centrifuge tube. A filtration unit (1) having a filter (7, 9) and a filtrate chamber (5) is placed within the container (30). Preferably the exterior of the filtration... Agent: Vinson & Elkins, L.L.P.

20070122807 - Posh polypeptides, complexes and related methods: The application provides novel complexes of POSH polypeptides and POSH-associated proteins. The application also provides methods and compositions for treating POSH-associated diseases such as neurological disorders.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070122806 - Predicting graft rejection: The present invention features prognostic methods useful in assessing patients who have received a transplant and reagents, optionally packaged as kits or organized as arrays, that can be used to carry out those methods. The inventions are based, in part, on our analysis of gene expression in renal allografts and... Agent: Fish & Richardson PC

20070122832 - Process for preparing l-amino acids: The invention relates to isolated polynucleotides comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID No. 2, b) polynucleotide which... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20070122830 - Prohibitin-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance: Disclosed are methods for treating neoplastic cells, including reversing or preventing chemotherapeutic drug resistance, by increasing the sensitivity of the neoplastic cells to a chemotherapeutic drug. In addition, methods are further disclosed for diagnosing chemotherapeutic drug resistance in neoplastic cells by detecting an increase in the expression of prohibitin in... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070122828 - Short cycle methods for sequencing polynucleotides: The invention provides methods for sequencing a polynucleotide comprising stopping an extension cycle in a sequence by synthesis reaction before the reaction has run to near or full completion.... Agent: Goodwin Procter LLP Patent Administrator

20070122815 - Solid support for nucleic acid detection: The present invention relates to solid supports for control nucleic acids. The present invention also relates to methods for the manufacture thereof, and methods of use thereof.... Agent: Nixon & Vanderhye, PC

20070122827 - Target nucleic acid signal detection: Provided herein are methods, compositions and kits for detecting a target nucleic acid. A target nucleic acid can be produced, for example, by a cleavage reaction in an assay for detection of biological samples. In one aspect, a described method comprises the following steps: hybridizing the target nucleic acid having... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070122813 - Use of cripto-1 as a biomarker for neurodegenerative disease and method of inhibiting progression thereof: A method of detecting a neurodegenerative disease in a mammal, which method comprises assaying the copy number of a Cripto-1 gene or the expression level of a Cripto-1 gene product in the central nervous system of the mammal, wherein an amplification of the Cripto-1 gene or an overexpression of the... Agent: Leydig, Voit & Mayer, Ltd.

20070122846 - Anti-human mitochondrial adenylate kinase isozyme antibody, diagnostic formulation and diagnostic kit for cardiac disease: The present invention relates to an immunological formulation and a diagnostic kit for cardiac disease using human mitochondrial adenylate kinase isozymes. The present invention provides an immunological formulation and a diagnostic kit for cardiac disease, which are featured by using mitochondrial adenylate kinase isozymes which exist in a myocardiac cell... Agent: Foley And Lardner LLP Suite 500

20070122840 - Assay panel comprising food allergens: There is described a substrate to which is applied, coupled or cross-linked to at least one part of said substrate an allergen wherein said allergen is a protein derived from an extract selected from at least one of the following food groups: cereal, legume, cocoa bean, nut, fruit, vegetable, shellfish,... Agent: Morgan, Lewis & Bockius LLP (sf)

20070122848 - Biochemical reaction cassette and detection apparatus for biochemical reaction cassette: A biochemical reaction cassette comprises: a substrate carrying probes immobilized thereon, the probes being adapted to be specifically bound to a target substance; a reaction space forming member for forming a reaction space with the substrate; an elastic member; and an anchor member for supporting the substrate so as to... Agent: Fitzpatrick Cella Harper & Scinto

20070122843 - Isoflavonoid analogs and their metal complexes as anti-cancer agents: A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal... Agent: Rohm & Monsanto, PLC

20070122841 - Massively parallel synthesis of proteinaceous biomolecules: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly... Agent: Blakely Sokoloff Taylor & Zafman

20070122842 - Massively parallel synthesis of proteinaceous biomolecules: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides and polymers joined by peptide bonds may be fabricated in a highly... Agent: Blakely Sokoloff Taylor & Zafman

20070122845 - Methods for identifying gpr83 agonists and gpr83 antagonists capable of modulating regulatory t cell function: The present invention provides methods for identifying a GPR83 agonist capable of stimulating a regulatory T cell function and methods for identifying a GPR83 antagonist capable of suppressing a regulatory T cell function.... Agent: Lahive & Cockfield, LLP

20070122847 - Mitochondrial markers of ischemia: Damage to tissue, such as ischemic damage, can cause the release of mitochondrial proteins. The released proteins can be detected in a sample taken from a subject, indicating that the subject has suffered damage.... Agent: Michaud-duffy Group LLP

20070122851 - Novel fluorescent and colored proteins, and polynucleotides that encode these proteins: The subject invention provides new fluorescent and/or colored proteins, and polynucleotide sequences that encode these proteins. The subject invention further provides materials and methods useful for expressing these detectable proteins in biological systems.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070122850 - Reduction of non-specific binding in assays: Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the... Agent: Dade Behring Inc. Legal Department

20070122844 - Reduction of redundant protein identification in high throughput proteomics: There is provided a method for the identification of proteins with reduced redundancy in protein hits. The method eliminates protein hits that are described by peptides sets that are included in at least one other protein hit associated peptides set.... Agent: Bereskin And Parr

20070122849 - Rhesus monkey p2x7 purinergic receptor and uses thereof: A P2X7 purinergic receptor has been isolated from the genome of Macaca mulatta (Rhesus monkey). Described is the amino acid sequence of the receptor, the nucleic acid encoding the receptor, and methods for using the receptor to identify analytes that are agonists or antagonists of the receptor.... Agent: Merck And Co., Inc

20070122852 - Method for identifying antigen specific b cells: The present invention relates to a method of identifying a B cell carrying a surface immunoglobulin molecule having a binding site for an antigen of interest comprising contacting a sample putatively containing said B cell with the antigen of interest wherein said antigen is labeled with a first label and... Agent: Fulbright & Jaworski L.L.P.

20070122853 - Methods and compositions for detecting larval taenia solium with a cloned diagnostic antigen: Compositions and methods for the detection of Taenia solium and the diagnosis of T. solium infection are described. The nucleotide and amino acid sequences of the antigenic T. solium polypeptides gp50a, gp50b and gp50c are provided. The compositions contain synthetic antigenic polypeptides of larval origin prepared using the sequences described... Agent: Klarquist Sparkman, LLP

20070122854 - Method for diagnosing colon cancer: The present invention relates to a method for diagnosing colon cancer by detecting a colon cancer specific antigen, defensin α6 from the blood of patient and a diagnostic kit for colon cancer comprising anti-defensin α6 antibody, The diagnostic kit for colon cancer of present invention comprises, a solid support such... Agent: Darby & Darby P.C.

20070122855 - Methods for diagnosing hepatocellular carcinoma: Methods are provided for hepatocellular carcinoma (HCC) diagnosis. The methods confirm the occurrence of HCC in a subject suspected of suffering from HCC by determining the level of either IL-6 or IL-10 in a plasma sample obtained from the subject. Also provided are methods for distinguishing HCC from other liver... Agent: Akin Gump Strauss Hauer & Feld L.L.P.

20070122856 - Tissue diagnostics for ovarian cancer: Disclosed are methods for diagnosing ovarian cancer in a cell sample by detecting an increase in the levels of expression of protein markers in the cell sample as compared to the levels of expression of the same protein markers in a normal, nonneoplastic ovarian cell sample. Also disclosed is a... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070122857 - Antibodies specific to antigens of bartonella henselae and use of these antigens in immunoassays: Disclosed are antibodies that bind to the antigenic proteins GroES, RplL, GroEL, SodB, UbiG, the ABC transporter, and an expressed antigenic protein of unknown function (the “BepA” protein) of Bartonella henselae, and use of these antigenic proteins in immunoassays in order to determine whether a sample from a subject contains... Agent: Medical Diagnostic Laboratories LLC

20070122858 - Cell-based fluorescence resonance energy transfer (fret) assays for clostridial toxins: The present invention provides a method of determining clostridial toxin activity by (a) contacting with a sample a cell containing a clostridial toxin substrate that includes a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence containing... Agent: Allergan, Inc.

20070122859 - Immunoassay for lsd and 2-oxo-3-hydroxy-lsd: The present invention provides hapten derivatives useful for the preparation of antigens, antibodies and reagents for use in immunoassays for the detection of LSD and 2-oxo-3-hydroxy LSD. In the present invention, the 2-oxy LSD nucleus is derivatized out of the indole nitrogen to form an aminoalkyl derivative. The resulting haptens... Agent: Roche Diagnostics Operations Inc.

20070122860 - Diagnosis and treatment of diseases arising from defects in the tuberous sclerosis pathway: The present invention relates to compositions and methods for identifying abnormalities in TSC signaling pathways. In particular, the present invention relates to methods of diagnosing and treating disorders such as tuberous sclerosis, which are caused by mutations in the TSC genes. The present invention further relates to methods and compositions... Agent: Medlen & Carroll, LLP

20070122861 - Cross-reactive sensors: The present invention provides a novel cross-reactive sensor system utilizing cross-reactive recognition elements. In the inventive system, each of said one or more cross-reactive recognition elements is capable of interacting with more than one species of liquid analyte of interest, whereby each of said one or more cross-reactive recognition elements... Agent: Sam Pasternak Choate Hall & Stewart

20070122863 - Methods and means for the detection of enzyme-catalyzed cleavage and linking reactions: The invention relates to methods and means for the detection of enzyme-catalyzed cleavage and linking reactions. Modular chemical compounds which serve as substrates for the enzymes involved are provided. The detection of the reaction products is effected by means of molecular-weight-sensitive methods.... Agent: Jacobson Holman PLLC

20070122862 - Screening for lipolytic enzymes or amidase activity: A method of testing samples for their enzymatic activity for hydrolysis of a particular ester or amide bond in a substrate uses a test substrate with one or more polyunsaturated fatty acyl groups linked through amide or ester bonds. The release of the polyunsaturated fatty acid is detected by the... Agent: Novozymes North America, Inc.

20070122864 - Methods for the determination of protein three-dimensional structure employing hydrogen exchange analysis to refine computational structure prediction: The present invention provides methods of structure prediction and/or determination of a protein of interest of unknown structure. Invention methods compare calculated rates of amide hydrogen exchange for a set of predicted possible structures for said protein with experimental hydrogen exchange analysis of said protein to identify valid protein structures... Agent: Foley & Lardner LLP

20070122865 - Enzymes and enzymic processes: A chimeric protein comprises a haem domain from a mammalian or plant cytochrome P450 and a scaffold domain generally comprising an electron transfer domain, from P450 BM3 of Bacillus megaterium. The protein does not include the membrane binding portion of the wild type mammalian or plant P450 and is hence... Agent: Sughrue Mion, PLLC

20070122866 - Protein having pge2 synthase activity and use thereof: A single protein which is the substance of the PGE2 synthesis activity in brain soluble fractions of LPS administered rats has been purified and identified. The protein has an activity of synthesizing PGE2 from PGH2, and further, has an activity of synthesizing PGE2 from arachidonic acid in combination with COX.... Agent: Fish & Richardson PC

20070122867 - Medical device for monitoring blood phenylalanine levels: A medical device adapted for the monitoring of blood levels of phenylalanine utilizing colormetric analysis, comprising a unit containing testing elements, or insertion means for receiving a substrate having a test biological sample thereon and a means on said device for displaying a test result for a level of phenylalanine... Agent: Greenberg Traurig, LLP

20070122868 - Gene 763 of phytopathogenic fungus magnaporthe grisea and use thereof for identifying fungicidal compounds: The invention concerns a novel nucleic acid fragment of the genome of rice pathogenic fungus Magnaporthe grisea comprising a gene coding for a protein (hereafter referred to as gene 763) whereof the presence and integrity are indispensable for pathogenesis of said fungus with respect to rice and barley. The invention... Agent: Connolly Bove Lodge & Hutz, LLP

20070122872 - Method for storage of clinical samples prior to culture: The present invention provides a storage media for the storage and transport of clinical samples. The storage medium comprises a microbiological growth medium, glycerol and a reducing agent. Clinical samples, such as sputum, can be added to the storage medium at the point of collection and then transported in the... Agent: Hodgson Russ LLP

20070122870 - Method for water testing and devices and kit of components for use in such a method: A method for the determination of water quality, which method comprises: contacting a vessel comprising a population of bacteria with a water sample to be tested, said vessel comprising a semi-permeable material which allows the water sample to pass therethrough and contact said bacteria; and determining the growth rate of... Agent: Nixon & Vanderhye, PC

20070122871 - Microbial strains producing sphingosine: The present invention provides a process to identify microorganisms that are capable of converting exogenous phytosphingosine into sphingosine. The microorganism possess a dehydratase activity. The process comprises the steps of providing a series of candidate microorganisms, incubating said series of candidate microorganisms in the presence of a suitable amount of... Agent: Oliff & Berridge, PLC

20070122869 - Organism-culture apparatus and culture method: An organism-culture apparatus, which can be conveniently prepared, can be stored for a long period, can be efficiently handled, and can be adapted to various organisms and culture conditions without restricting a kind of an organism to be cultured or the culture condition, and can be recycled after sterilization and... Agent: Birch Stewart Kolasch & Birch

20070122873 - Signal amplification using a synthetic zymogen: Described herein are zymogens, methods of use for zymogens, and devices that incorporate zymogens. The zymogens include a substrate and an enzyme. The substrate can inhibit the enzyme and is a target for a protein produced by a microorganism. When the substrate is modified by a protein produced by a... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070122874 - Novel microbial consortium and use thereof for liquefaction of solid organic matter: The present invention relates to a novel process for liquefaction of solid organic matter by biological method. By this process the solid organic matter can be hydrolyzed using anaerobically treated water containing a consortium of fermentative micro-organisms thus resulting in an organic liquid which can be digested easily when applied... Agent: Seed Intellectual Property Law Group PLLC

20070122879 - Cytokine receptor: Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention... Agent: Zymogenetics, Inc. Intellectual Property Department

20070122875 - Enzyme for decomposition of sulfated fucan derived from sea cucumber: Sulfated fucan lyase capable of decomposing sulfated fucan derived from sea cucumber; a process for producing the enzyme; a low molecular compound obtained by causing the enzyme to act on sulfated fucan; a process for producing the same; and an activating factor for sulfated fucan lyase.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070122882 - Gene specifically expressed in postmitotic dopaminergic neuron precursor cells: A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms of their safety, survival rate, and network... Agent: Townsend And Townsend And Crew, LLP

20070122883 - Human cytokine receptor: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor16.”... Agent: Zymogenetics, Inc. Intellectual Property Department

20070122878 - Human orphan g protein-coupled receptors: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors.... Agent: Cozen O'connor, P.C.

20070122876 - Nucleic acids for enhancing gene expression and use thereof: The present invention relates to a method for producing a protein, novel nucleic acid fragment, an expression vector, and a method for enhancing the protein production in Pichia. The present invention provides that the combination of the modified signal peptide, increased copy number of the gene, and/or overexpressed Sec4p resulted... Agent: Harness, Dickey & Pierce, P.L.C

20070122881 - Rhamnose-inducible expression systems and methods: Rhamnose-inducible expression constructs are described. The expression constructs may be either episomal or chromosomal and may include at least one rhamnose-inducible regulatory element expressing a regulatory protein and at least one promoter that is inducible by the regulatory protein. An open reading frame expressing a protein of interest may be... Agent: Knobbe Martens Olson & Bear LLP

20070122877 - T-cell vaccination in the treatment of hiv infection: A method for the preparation of a T cell vaccine for the treatment of immunodeficient HIV-infected patients is described herein, based on the enrichment of autologous CD4-reactive CD8 T cells. Also described is a protocol for the implementation of T cell vaccination in immunodeficient HIV-infected, as well as a method... Agent: Frommer Lawrence & Haug

20070122880 - Vector for the inducible expression of gene sequences: The invention relates to a nucleic acid construct that comprises a human EF-1α promoter operatively associated with the tetracycline repressor (TetR). The invention further provides cell lines that have been stably transfected with such construct, as well as methods of using said construct, for the inducible expression of a transgene... Agent: Nixon & Vanderhye, PC

20070122884 - Factor vii glycoforms: The present invention provides preparations of Factor VIIa polypeptides or Factor VIIa-related polypeptides that exhibit predetermined glycoform patterns. The preparations of the invention exhibit improved functional properties and are useful for treating Factor VII-mediated conditions.... Agent: Novo Nordisk, Inc. Patent Department

20070122885 - Methods of increasing production of secondary metabolites by manipulating metabolic pathways that include methylmalonyl-coa: A process of increasing the cellular production of secondary metabolites, such as antibiotics, is provided. The process is particularly useful for increasing antibiotic production by bacterial cells, especially erythromycin. The process includes the step of increasing the activity of methylmalonyl-CoA mutase.... Agent: Dykema Gossett PLLC

20070122886 - Cellulose production by facultatively anaerobic microorganisms: A method for producing bacterial cellulose, said method comprising culturing a biologically pure culture of a cellulose-producing Proteus strain in a liquid medium suitable for culturing facultatively anaerobic microorganisms, separating bacterial cellulose produced in said liquid medium from said liquid medium, washing said separated bacterial cellulose and drying said bacterial... Agent: Daniel R. Polonenko Fasken Martineau Dumoulin LLP

20070122887 - Gene variants coding for proteins from the metabolic pathway of fine chemicals: The present invention relates to mutated nucleic acids and proteins of the metabolic pathway of fine chemicals, to processes for preparing genetically modified producer organisms, to processes for preparing fine chemicals by culturing said genetically modified organisms and to said genetically modified organisms themselves.... Agent: Lahive & Cockfield, LLP

20070122888 - Method for the production of methionine: The present invention relates to a process for producing methionine by fermentation, a process for isolating the methionine formed, the methionine-containing biomass produced in isolation, use thereof for producing a feedstuff or feed supplement, and also to the use of the isolated methionine for producing foodstuffs or feedstuffs or food... Agent: Connolly Bove Lodge & Hutz, LLP

20070122890 - Microorganism of corynebacterium genus having enhanced l-lysine production ability and method of producing l-lysine using the same: Provided are a microorganism of Corynebacterium genus that has an inactivated endogenous NCgl1835 gene therein and produces L-lysine, and a method of producing L-lysine using the same.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070122889 - Microorganism of corynebacterium genus having resistance to kanamycin and enhanced l-lysine productivity and method of producing l-lysine using the same: Provided are a microorganism of Corynebacterium genus capable of producing L-lysine and resistant to kanamycin, and a method of producing L-lysine using the same.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070122891 - Methods for the preparation, isolation and purification of epothilone b, and x-ray crystal structures of epothilone b: The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent purification.... Agent: Louis J. Wille Bristol-myers Squibb Company

20070122892 - Process for producing succinic acid from sucrose: A process for hydrolyzing sucrose to glucose and fructose using succinic acid is described. The hydrolysate can be used to produce purified glucose and/or fructose or can be used as a carbon source for fermentations to produce various chemicals including succinic acid.... Agent: Ian C. Mcleod Mcleod & Moyne, P.C.

20070122893 - Process for preparing an immobilized enzyme: Provided is a process for preparing an immobilized enzyme, which comprises the steps of immobilizing an enzyme used for decomposing oil & fat on a carrier, by adsorption, without drying, bringing the immobilized enzyme into contact with a fatty acid triglyceride or fatty acid partial glyceride, or mixtures thereof, and... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070122894 - Sterile microbiological nutrient media device and methods of using: The present invention relates to a device for assisting in the preparation of a sterile, microbiological nutrient media of a predetermined concentration. In general, such a device comprises three elements. An outer flexible envelope has a re-sealable opening. This outer envelope is comprised of a material that does not transmit... Agent: Brian D. Voyce

20070122895 - Pichia methanolica secretory signal: Novel Pichia methanolica secretory signal polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods of using are disclosed. Methods of producing large amounts of recombinant proteins by employing DNA constructs having a polypeptide of interest preceded by a novel Pichia methanolica secretory signal sequence.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070122896 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati

20070122897 - Micro device for cell culture: A micro device for cell culture is disclosed, which cooperates with a fluid and includes: a top plate having an inlet port; a orifice plate having a plurality of orifices; a culture plate having a plurality of culture wells and a plurality of injection ports; and a bottom plate having... Agent: Bacon & Thomas, PLLC

20070122898 - Device for forming magnetic well for nanoparticles: A device includes a plurality of structures, each structure including at least one ferromagnetic layer having fringe fields. Fringe fields of the structures interact to form a magnetic well for nanoparticles. This device may be adapted for biosensing, wherein the magnetic well is formed about a probe area.... Agent: Hewlett Packard Company

20070122899 - Target substance analysis apparatus and determination software update method: There is provided a biochemical reaction cassette analysis apparatus capable of automatically updating determination software. A biochemical-reaction-cassette-equipped automatic analysis apparatus having a storage section in which determination software is stored in association with its version information and identification information for identifying the kind of probe on a probe carrier is... Agent: Fitzpatrick Cella Harper & Scinto

20070122900 - Bioscrubber: A bioscrubber for purifying dirty gas has a circulated scrubbing liquid which contains water and microorganisms for degradation of the substances to be separated off from the dirty gas. The gas enters at an inlet, moves through a mass-transfer zone, where it undergoes a phase change from the gas phase... Agent: Lerner Greenberg Stemer LLP

20070122903 - Amniotic fluid derived cells: This invention relates to an expandable population of amniotic fluid-derived cells that can be differentiated into a β-cell lineage. This invention also provides methods for isolating and expanding such amniotic fluid-derived cells, as well as related methods and compositions for utilizing such cells in the therapeutic treatment of diabetes.... Agent: Philip S. Johnson Johnson & Johnson

20070122904 - Method and apparatus for culturing cells: A method for culturing cells, the method comprising: providing a plurality of cellulose hollow fibre capillaries having cells and at least one protein required for proliferation, differentiation and/or genetic modification of the cells therein and optionally at least one metabolite; and providing on the extracapillary side of the semi-permeable substrate... Agent: Nixon & Vanderhye, PC

20070122902 - Method for isolating and culturing multipotent progenitor/stem cells from umbilical cord blood and method for inducing differentiation thereof: Since the multipotent progenitor/stem cells isolated and cultured from the cord blood-derived mononuclear cells according to the method of the present invention are capable of differentiating into several types of cells including neurons, osteoblasts, myoblasts, endothelial cells, hepatocytes and dendritic cells, they can be effectively used for a cell therapy,... Agent: Sughrue Mion, PLLC

20070122901 - Method of constructing artificial cell tissue and base material therefor: The present invention relates to a method for culturing cells, which comprises the steps of: causing cells to adhere to the surface of a cell array substrate having a cell adhesiveness variation pattern that comprises regions having good cell adhesiveness and regions having inhibited cell adhesiveness patterned on a substrate;... Agent: Sughrue Mion, PLLC

20070122905 - Pdx1-expressing dorsal and ventral foregut endoderm: Disclosed herein are cell cultures comprising dorsal and/or ventral PDX1-positive foregut endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified dorsal and/or ventral PDX1-positive foregut endoderm cells as well as methods for enriching, isolating and purifying dorsal and/or ventral PDX1-positive foregut endoderm... Agent: Knobbe Martens Olson & Bear LLP

20070122906 - Method of culturing cells: A blood component such as platelets are concentrated from the blood. The concentrate such as platelet-rich plasma is used in a cell culture medium to grow and proliferate cells. The cells may be from the same person from which the blood concentrate is obtained. The cells grown in the culture... Agent: Knobbe Martens Olson & Bear LLP

20070122907 - Orchid culturing method: The invention describes a method to increase the number of inflorescences and/or minimise the need for a cold period for the induction of an inflorescence in an orchid by administration of a cytokinin, preferably 6-BAP, to said orchid, preferably wherein said orchid has a monopodial growth, more preferably wherein said... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20070122908 - Molecular delivery to cells using aspirin-related compounds: The present invention provides for a system and method whereby aspirin and acetic acid help to permeabilize cell membranes to allow exogenous molecules to gain access to the cell interior. As such, the present invention provides a low cost drug and gene delivery tool that can be applied in combination... Agent: Smith Hopen, Pa

20070117085 - Method and device for culturing live cells by coupling a bioreactor receiver with a selection automation: The invention relates to a method for continuously, semi-continuously or discontinuously treating a substrate (24) consisting in placing said substrate in a bioreactor receiver (1) and in exposing it to the action of a living cell culture (C1) which makes it possible to carry out a reaction (R1) on the... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070117086 - Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm: A flow cytometry system (1) for sorting haploid cells, specifically irradiatable sperm cells, with an intermittingly punctuated radiation emitter (56). Embodiments include a beam manipulator (21) and even split radiation beams directed to multiple nozzles (5). Differentiation of sperm characteristics with increased resolution may efficiently allow differentiated sperm cells to... Agent: Santangelo Law Offices, P.C.

20070117087 - Method of providing readily available cellular material derived from peripheral blood, and a compositoin thereof: Method of researching disease states using TVEMF-expanded cells.... Agent: Ladas & Parry LLP

20070117088 - Methods and kits for detection of prion diseases: The invention relates to diagnostic methods and kits for detecting transmissible spongiform encephalopathies (TSEs) such as BSE, scrapie, chronic wasting disease and related diseases in animals and humans. The invention provides a method for determining whether an aberrant prion protein is present or absent in a mammalian sample comprising the... Agent: Ladas & Parry

20070117089 - Sol-gel coated glass microspheres for use in bioassay: A microsphere for use in a bioassay comprising a glass core coated with a sol-gel comprising a bioactive probe is provided. The sol-gel coating enhances the density of bioprobe loading on the surface of the microspheres, resulting in enhanced dynamic range and sensitivity in bioassays. The particle may be used... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070117098 - 'signalin' family of tgfbeta signal transduction proteins and uses related thereto: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here signalin-related genes, which are involved in a signal transduction induced by members of the TGFβ superfamily. The present invention makes available compositions and methods that can be utilized, for example to generate and/or... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070117124 - Achaete-scute like-2 polypeptides and encoding nucleic acids and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Genentech, Inc.

20070117146 - Allelic variants of gpr50: The present invention provides isolated polynucleotides encoding a receptor gene called GPR50 having at least one polymorphic sites. It furthermore provides a method for analyzing polymorphic sites in the receptor gene. Certain of these polynucleotides having a polymorphic site (allelic variants) are found to be more prevelant in a population... Agent: Akzo Nobel Inc.

20070117091 - Anti-candida agents for the treatment of prion diseases: The invention provides methods of treatment of prion disease, cancers and other conditions, the methods comprising administration of an anti-Candida agent. Also disclosed are methods of diagnosing prion disease and cancers, said methods based on the determination of the presence of Candida infection, in particular systemic candidiasis.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070117129 - Antigen arrays for treatment of bone disease: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or antigenic determinant array, and in particular a RANKL protein, RANKL fragment or RANKL peptide-VLP-array. More specifically, the invention provides a composition comprising a... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070117143 - Atm related kinase atx, nucleic acids encoding same and methods of use: The invention provides an isolated nucleic acid molecule having substantially the same nucleotide sequence as SEQ ID NO:1. Also provided is an isolated oligonucleotide having at least 15 contiguous nucleotides of a nucleotide sequence referenced as SEQ ID NO:11. An isolated polypeptide having substantially the same amino acid sequence as... Agent: Mcdermott, Will & Emery

20070117100 - Biomarker for determining predisposition and/or prognosis of hepatocellular carcinoma: Disclosed herein are a method for determining predisposition to hepatocellular carcinoma (HCC) in a subject having or suspected to have a hepatic nodule, in particular one infected with at least one of hepatitis B virus and hepatitis C virus, and a method for prognostic evaluation of a subject having or... Agent: Paul D. Greeley, Esq. Ohlandt, Greeley, Ruggiero & Perle, L.L.P.

20070117119 - Carriers having biological substance: The present invention relates to biological substance-immobilized fibers wherein a biological substance is immobilized on a fiber, fibers retaining a biological substance-immobilized gel, and fiber alignments having bundles of the above-described fibers and slices of the same.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070117121 - Cdna library preparation: New biochemical protocols for high throughput processing of mRNA samples into cDNA libraries with adaptor sequences compatible with automated sequencing systems are provided. The provided methods produces cDNA libraries which do not have 3′ bias associated with current cDNA library production methods. New methods for the production of DNA libraries... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20070117101 - Cleavable oligonucleotide arrays: Oligonucleotide arrays having features that include cleavable oligonucleotides are disclosed, as well as methods of making such arrays. Methods of synthesizing an oligonucleotide on a surface of a substrate are described.... Agent: Agilent Technologies Inc.

20070117114 - Compositions and methods for increasing amplification efficiency: Compositions and methods are provided that improve the specificity and efficiency of nucleic acid amplification. A binding partner may be bound to a DNA polymerase enzyme where the binding partner substantially inhibits the activity of the polymerase. A second enzyme modifies the binding partner in a manner that relieves the... Agent: Proskauer Rose LLP

20070117127 - Cross-species nucleic acid probes: The present invention features a collection of at least four nucleic acid probes. The probes each comprises a segment, the entirety of which hybridizes under low stringency conditions to at least a first gene of a first species and a second gene of a second species, wherein the hybridizing probes... Agent: Fish & Richardson PC

20070117136 - Detection of microsatellite instability and its use in diagnosis of tumors: Methods and kits are disclosed for use in the analysis of microsatellite instability in genomic DNA. Methods and kits are also disclosed which can be used to detect microsatellite instability DNA present in biological materials, such as tumors. The methods and kits of the present invention can be used to... Agent: Michael Best & Friedrich, LLP

20070117108 - Detection system for pcr assay: The present invention provides a detection system for a PCR process using FRET which comprises at least two single-labelled Oligonucleotide sequences of differing Tm that hybridise to one another in free solution to form a fluorescent quenched pair, that upon introduction of a complementary sequence to one or both sequences... Agent: Bradley N. Ruben, PC

20070117095 - Diagnostic method for neonatal or infantile epilepsy syndromes: A method for the diagnosis of a neonatal or infantile epilepsy syndrome as BFNIS in a patient comprising testing for the presence of an alteration in the SCN2A gene, including in a regulatory region of the gene, in a patient sample, and establishing a diagnosis which will indicate a high... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20070117115 - Discrimination method of target base in dna, and allele specific primer used in the method of the same: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one... Agent: Mcdermott Will & Emery LLP

20070117116 - Discrimination method of target base in dna, and allele specific primer used in the method of the same: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one... Agent: Mcdermott Will & Emery LLP

20070117117 - Discrimination method of target base in dna, and allele specific primer used in the method of the same: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one... Agent: Mcdermott Will & Emery LLP

20070117118 - Discrimination method of target base in dna, and allele specific primer used in the method of the same: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is C, while a base adjacent with one... Agent: Mcdermott Will & Emery LLP

20070117092 - Dna analysis system: A DNA analysis system 10 includes a thermal cycler 12 operable as an extraction stage for extracting DNA from a sample to be tested and an as amplification stage for replicating identically a region of interest in DNA strands extracted from the sample. A predetermined proteinase is used in the... Agent: Hogan & Hartson LLPIPGroup, Columbia Square

20070117110 - Flow cytometric detection method for dna samples: Disclosed herein are two methods for rapid multiplex analysis to determine the presence and identity of target DNA sequences within a DNA sample. Both methods use reporting DNA sequences, e.g., modified conventional Taqman® probes, to combine multiplex PCR amplification with microsphere-based hybridization using flow cytometry means of detection. Real-time PCR... Agent: John H. Lee Assistant Laboratory Counsel

20070117093 - Heavymethyl assay for the methylation analysis of the gstpi gene: Described herein is a method for the detection of cyto-sine methylation in DNA samples, wherein the following steps are conducted: a genomic DNA sample, which comprises the DNA to be investigated as well as background DNA is treated with bisulfite (= disulfite, hydrogen sulfite) in such a way that all... Agent: Kriegsman & Kriegsman

20070117141 - Identification and cloning of a full-length human clnk-related gene, mist (mast cell immunoreceptor signal transducer): The present invention describes a newly discovered full-length polynucleotide encoding an SH2 domain-containing adapter protein, called human MIST, cloned, isolated and identified from a human spleen cDNA library. Also described are the MIST polypeptide sequence, expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies related to the polynucleotide and/or... Agent: Louis J. Wille Bristol-myers Squibb Company

20070117106 - Identification and/or quantification method of nucleotide sequence (s) elements specific of genetically modified plants on arrays: The present invention is related to an identification and/or quantification method of several organisms among many other ones possibly present in the analyzed sample having homologous sequence(s) by the determination of the genetic map of the organism. The method combines a limited number of amplifications of target sequence(s) using common... Agent: Knobbe Martens Olson & Bear LLP

20070117105 - Interferon assay: The present invention relates to methods and reporter cell assays for determining the ability of a patient sample to induce interferon target gene expression in interferon responsive cells. These methods will be useful for detecting, diagnosing, and monitoring those who have or are at risk of various autoimmune disorders or... Agent: Darby & Darby P.C.

20070117145 - Interferon-alpha induced genes: The present disclosure relates to identification of previously known genes as being genes upregulated by interferon-α administration, in particular the human genes corresponding to the cDNA sequence in GenBank designated g4758303, g5453897, g4505186, g2366751, g33917, g4504962, g3978516, g5924396, g4505656, g1504007, g3702446, g4001802, g292289, g4557226, g4507646 and g4507170. Determination of expression... Agent: Alston & Bird LLP

20070117112 - Materials and methods for the generation of fully 2'-modified nucleic acid transcripts: Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070117134 - Method for detection and quantification of t-cell receptor vbeta repertoire: The invention is a method for detecting and measuring T-cell receptor (TCR) repertoires from mammalian lymphocytes. The method is based on the use of the multiple sets of unique primers to amplify 22 regions of the TCR Vβ region and thereby detect clonal expansions related to antigen stimulation of the... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070117140 - Method for selecting antimicrobial agent and utilization thereof: The present invention provides for a method for selecting an antimicrobial agent, which comprises a microbe analyzing step in which microbes in the microbial biota of a sample are analyzed based on base sequence of DNA and an antimicrobial agent selecting step comprising performing search in a data base storing... Agent: Flynn Thiel Boutell & Tanis, P.C.

20070117137 - Method for the determination of a nucleic acid using a control: The present invention is directed to a method for the determination of a target nucleic acid using a special control nucleic acid, a method for the amplification of a partial sequence of said target nucleic acid using primers, a special control and a kit containing said control. The sequence of... Agent: Townsend And Townsend And Crew, LLP

20070117125 - Method of detecting specific fragments of dna or rna with the aid of a real-time polymerase chain reaction: Methods of amplifying specific fragments of DNA or RNA with the aid of a polymerase chain reaction in real time are disclosed. The methods include providing a first oligonucleotide primer that comprises a donor fluorescent dye and a second oligonucleotide primer that comprises an acceptor fluorescent dye; allowing the primers... Agent: Fish & Richardson PC

20070117135 - Method of inoculation for evaluating candidate therapies for prevention of acquisition of infectious diseases: A method of inoculating the vestibular region of the nares with virus, bacteria, fungus, or mold to ascertain whether acquisition and/or prevention of transmission of infection may occur.... Agent: Robert M. Downey, P.A.

20070117139 - Method of manufacturing probe carrier: A flat plate-shaped probe carrier for carrying probes such as single stranded DNAs, proteins, etc., which are reactive specifically with target substances comprises a plurality of ring bodies arranged substantially in parallel and the external space among the ring bodies is filled with a filler such that the openings of... Agent: Fitzpatrick Cella Harper & Scinto

20070117107 - Methods and compositions for the identification of antibiotics that are not susceptible to antibiotic resistance: Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome function. The compositions and methods of... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070117122 - Methods of diagnosing or prognosticating age-related macular degeneration: A method for diagnosing or prognosticating age-related macular degeneration in a subject, or determining whether a subject is at increased risk of developing age-related macular degeneration or monitoring the progression of age-related macular degeneration in a subject, comprising: determining a level, or an activity, or both said level and said... Agent: Jacobson Holman PLLC

20070117111 - Microfabricated reactor, process for manufacturing the reactor, and method of amplification: An integrated microfabricated instrument for manipulation, reaction and detection of microliter to picoliter samples. The instrument is suited for biochemical reactions, particularly DNA-based reactions such as the polymerase chain reaction, that require thermal cycling since the inherently small size of the instrument facilitates rapid cycle times. The integrated nature of... Agent: Cooley Godward LLP The Bowen Building

20070117120 - Mycoplasma detection method and composition: A method of detecting the presence of mycoplasma in a sample and a mycoplasm detection kit. A sample is contacted with a first and a second oligonucleotide probe, wherein the first and second oligonucleotide probes are substantially complementary to portions of a 16S ribosomal subunit of at least one mycoplasma... Agent: Intellectual Property Group Fredrikson & Byron, P.A.

20070117109 - Nanostructures, methods of making and using the same: The disclosure relates to methods and composition for generating nanoscale devices, systems, and enzyme factories based upon a nucleic acid nanostructure the can be designed to have a predetermined structure.... Agent: Buchanan, Ingersoll & Rooney LLP

20070117130 - Novel activin receptor and uses thereof: The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the receptor polypeptides. Compositions and methods for treating muscle-wasting, metabolic and other disorders are also... Agent: Amgen Inc. Law Department

20070117097 - Novel proteins and novel genes encoding the same: Novel proteins, novel genes encoding the same, plasmids respectively comprising these genes, transformants respectively comprising these plasmids, antibodies or fragments thereof against the above novel proteins, methods of detecting a bacterial infection, and novel polynucleotides are disclosed. The novel proteins are activated human macrophage-specific proteins.... Agent: Darby & Darby P.C.

20070117113 - Nucleic acid fragment encoding an nrps for the biosynthesis of anthramycin: Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin from Streptomyces refuineus subsp. thermotolerans. The genes and proteins allow direct manipulation of benzodiazepines and related chemical structures via chemical engineering of the enzymes involved in... Agent: Sughrue Mion, PLLC

20070117102 - Nucleotide analogs: The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.... Agent: Goodwin Procter LLP Patent Administrator

20070117103 - Nucleotide analogs: The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.... Agent: Goodwin Procter LLP Patent Administrator

20070117104 - Nucleotide analogs: The invention provides nucleotide analogs for use in sequencing nucleic acid molecules.... Agent: Goodwin Procter LLP Patent Administrator

20070117144 - Oligonucleotides useful for detecting and analyzing nucleic acids of interest: The invention features improved nucleic acids and methods for expression profiling of mRNAs, identifying and profiling of particular mRNA splice variants, and detecting mutations, deletions, or duplications of particular exons or other splice variants, e.g., alterations associated with a disease such as cancer, in a nucleic acid sample, e.g., a... Agent: Clark & Elbing LLP

20070117096 - Oscillating temperature capillary electrophoresis and uses therefor: Methods for separating biomolecules using oscillating temperature electrophoresis are disclosed. Uses for such methods are also disclosed including high throughput screening, estimation of allele frequencies, identification of polymorphisms, and separation of DNA molecules.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070117099 - Process and apparatus for combinatorial synthesis: Apparatus and methods are described for split synthesis combinatorial chemistry that provides candidate libraries where an even distribution of theoretical products is obtainable through even mixing during the pooling step, followed by controlled redistribution of the mixed pooled products from the prior addition step into separate synthesis columns, one for... Agent: Wong, Cabello, Lutsch, Rutherford & Brucculeri, L.L.P.

20070117131 - Processes for the replication of influenza viruses in cell culture, and the influenza viruses obtainable by the process: Novel processes for the replication of influenza viruses in cell culture, and vaccines and diagnostic compositions which contain the influenza viruses obtainable by the process or constituents thereof, are described.... Agent: Novartis Vaccines And Diagnostics Inc.

20070117090 - Processing nucleic acid: The present invention relates to a method of processing nucleic acid. More particularly, it relates to a method of purifying extra-chromosomal DNA by removing cell debris and/or RNA from a process stream comprising extra chromosomal DNA and a precipitate resulting from preceding cell lysis and/or precipitation reactions. It also relates... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20070117128 - Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity: Rationally-designed LAGLIDADG (SEQ ID NO: 37) meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070117142 - Regulation of novel human asparagine-hydroxylases: Reagents that regulate human asparagine-hydroxylase and reagents which bind to human asparagine-hydroxylase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to cardiovascular disorders, anaemia, cancer, inflammatory diseases, fibrotic disorders, and CNS disorders.... Agent: Jeffrey M. Greenman

20070117123 - Salivary protein and rna for breast cancer detection: The present invention provides for the first time the identification of salivary protein and RNA factors that are elevated in breast cancer. The present invention therefore provides methods of diagnosing and providing a prognosis for breast cancer, by examining cancer antigens (protein and RNA) in saliva.... Agent: Townsend And Townsend And Crew, LLP

20070117126 - Shotgun scanning: A combinatorial method that uses statistics and DNA sequence analysis rapidly assesses the functional and structural importance of individual protein side chains to binding interactions. This general method, termed “shotgun scanning”, enables the rapid mapping of functional protein and peptide epitopes and is suitable for high throughput proteomics.... Agent: Merchant & Gould PC

20070117133 - Sparc and methods of use thereof: The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of... Agent: Leydig Voit & Mayer, Ltd

20070117138 - Splice variant cannabinoid receptor (cb1b): The invention is based on the identification of a novel splice variant of human cannabinoid 1 (CB1) receptor, termed CB1b, and its use in the identification of therapeutic agents and in the diagnosis, prevention and treatment of CB associated disorders such as obesity, psychiatric, pain and neurological disorders.... Agent: Astrazeneca R&d Boston

20070117094 - Support, printed material and reagent kit having enzyme fixed thereon, method for preparing the support, method of storing enzyme and method for restoration enzymes: The invention enables enzymes to be stored in a simple manner. Disclosed are a support having an enzyme and a protecting agent for the enzyme fixed thereon; a printed material and a reagent kit comprising the support; a method for preparing the support; a method for restoring the enzyme fixed... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070117132 - System and method for analyzing dependence between gene expressions: An amplification-like, unidirectional dependence between expression levels in gene pairs is identified through statistical analysis including a determination of whether there is a specified level of independence (or non-correlation) between X and Z, where X is a random variable representing the expression level of a first gene, Y is a... Agent: Blank Rome LLP

20070117152 - Biosensor: An object of the present invention is to provide a biosensor that is capable of immobilizing large quantities of physiologically active substances thereon. The present invention provides a biosensor comprising a substrate having on its surface a polysaccharide capable of chemically immobilizing physiologically active substances, wherein the polysaccharide is a... Agent: Sughrue Mion, PLLC

20070117147 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070117148 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070117149 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070117150 - Carbon nanotube binding peptides: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070117154 - Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery: where part (T) is a —Y-L-Z- radical where in Y is CH2or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation... Agent: Myers Bigel Sibley & Sajovec

20070117155 - Histamine receptor: The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070117151 - Method and apparatus for detecting an analyte: A method for determining a concentration of an analyte is provided. The method includes providing a substrate including a conductive region and a recognition layer where the conductive region has a first surface operatively coupled with the recognition layer; The method also includes contacting the substrate with the sample to... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070117156 - Method of detecting native probnp: The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody... Agent: Roche Diagnostics Operations Inc.

20070117153 - Molecular conjugate: A method is disclosed for making a conjugate of two molecules using a hydrazide thiol linker. In a particular working embodiment, an Fc-specific antibody-enzyme conjugate is made using the method and demonstrated to provide exceptional staining sensitivity and specificity in immunohistochemical and in situ hybridization assays.... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20070117161 - Antibody specific for human 4-1bb receptor: The human receptor H4-1BB has been isolated, sequenced and disclosed herein. The cDNA of the human receptor H4-1BB is about 65% homologous to the mouse cDNA 4-1BB and was isolated by using probes derived from cDNA 4-1BB. A fusion protein for detecting cell membrane ligands to human receptor protein H4-1BB... Agent: Barnes & Thornburg LLP

20070117162 - Kidney-specific urate transporter and gene thereof: It is intended to identify and provide a novel urate transporter gene participating in the urate transport in the kidney and a urate transporter which is a polypeptide encoded by the above gene. Namely, a protein comprising the amino acid sequence represented by SEQ ID NO: 1 or an amino... Agent: Edwards & Angell, LLP

20070117158 - Methods and algorithms for cell enumeration in a low-cost cytometer: The enumeration of cells in fluids by flow cytometry is widely used across many disciplines such as assessment of leukocyte subsets in different bodily fluids or of bacterial contamination in environmental samples, food products and bodily fluids. For many applications the cost, size and complexity of the instruments prevents wider... Agent: Joseph Aceto Immunicon Corp

20070117160 - Novel method of screening: The present invention relates to screening of an agonist/antagonist, etc. Specifically, the present invention provides a method of screening an agonist or antagonist of a G protein-coupled receptor protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1,... Agent: Edwards & Angell, LLP

20070117157 - Parathyroid hormone-like polypeptides: Novel parathyroid hormone polypeptides and biologically active fragments thereof are disclosed along with nucleic acid molecules encoding same. In particular, parathyroid hormone polypeptides and biologically active fragments (and encoding nucleic acid molecules) derived from fish species (eg Japanese pufferfish (Fugu rubripes)) are disclosed. Such polypeptides and fragments may be used... Agent: Sheridan Ross PC

20070117159 - Receptor for b. anthracis toxin: The present invention relates to mammalian anthrax toxin receptor polypeptides and polynucleotides encoding same as well as related polypeptides and polynucleotides, vectors containing the polynucleotides and polypeptides, host cells containing related polynucleotide molecules, and cells displaying no anthrax toxin receptor on an exterior surface of the cells-minus cell lines and... Agent: Quarles & Brady LLP

20070117163 - Anti-aurora-a monoclonal antibody, method for obtaining same and uses thereof for diagnosing and treating cancers: The invention concerns a monoclonal antibody directed against mammalian aurora-A kinase, the method for obtaining same, as well as its uses in cancer diagnosis and prognosis, and in pharmaceutical compositions for cancer treatment.... Agent: Clark & Elbing LLP

20070117164 - Method for detection of colorectal cancer in human samples: The present invention relates to a method of diagnosing colorectal cancer in human samples using several novel protein markers. The markers have been identified by assaying a number of tissue and serum samples from healthy individuals and persons diagnosed with colorectal cancer by means of protein chip technology using mass... Agent: Roberts, Mlotkowski & Hobbes

20070117165 - Methods of detecting cancer with antibodies to cytokine receptor zcytor19: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor... Agent: Zymogenetics, Inc. Intellectual Property Department

20070117167 - Monoclonal antibodies and methods for their use in the detection of cervical disease: Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that... Agent: Alston & Bird LLP

20070117168 - Perinucleolar compartment as a cancer marker: The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers.... Agent: Medlen & Carroll, LLP

20070117166 - Use of ulip proteins in the diagnosis and therapy of cancers and paraneoplastic neurological syndromes: The invention relates to the use of proteins designated ULIP/POP in the diagnosis and therapy of cancers and paraneoplastic neurological syndromes.... Agent: Stites & Harbison PLLC

20070117169 - (1-3)-beta-d-glucan binding domain protein, measuring method using the substance and assay kit: A (1→3)-β-D-glucan binding protein, a fluorescence-labeled (1→3)-β-D-glucan binding domain protein, a (1→3)-β-D-glucan measuring agent comprising the same, a method for measuring (1→3)-β-D-glucan using the same, and a (1→3)-β-D-glucan assay kit comprising the same.... Agent: Sughrue-265550

20070117170 - Method for cleaving and deglycosylating antibodies to promote ligand binding: The present invention details methods to detect glycoproteins in samples to identify a disease state. In particular, an improved sandwich assay is described, using both an antibody and an array of lectins. Methods for increasing the efficiency of interaction of an antibody with a ligand by cleaving the antibody to... Agent: King & Spalding LLP

20070117171 - Method of manufacturing a diagnostic test strip: A method for manufacturing a test strip is provided. The method comprises selecting a test strip substrate material and positioning the test strip substrate material a predetermined distance from a matrix material disposed on a second substrate, wherein at least one enzyme to be deposited on the test strip substrate... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070117172 - Microorganism detector: A device for the characterisation of microorganisms comprising a porous body having regions of differing pore size said regions being associated with different chromogens specific to enzymes produced by microorganisms.... Agent: Kilpatrick Stockton LLP

20070117173 - Stable storage of proteins: The present invention provides a method of stably storing a protein, the method comprising applying a protein to be stored to a substrate which has been treated with a polyhydric compound and dried, wherein the amount of the polyhydric compound present in the substrate is sufficient to stabilise the protein,... Agent: Edwards & Angell, LLP

20070117174 - Chimeric protein and its use in electron transfer methods: A chimeric protein comprises a redox catalytic domain from one source and an electron transfer domain from a different source. The protein is used in a method in which a substrate for the redox catalytic domain is acted on, electrons are transferred between the redox catalytic domain and the electron... Agent: Sughrue Mion, PLLC

20070117175 - Airborne bacterial spores as an indicator of biomass in an indoor environment: Bacterial endospore concentration is an indicator of microbial contamination in an indoor environment. In accordance with the disclosed method, a measurement of the bacterial endospore concentration of an indoor environment correlates to the microbial mass in said indoor environment.... Agent: Alessandro Steinfl, Esq. C/o Ladas & Parry

20070117178 - Continuous polymer synthesizer: Described is a system and method for synthesizing polymeric molecules such as oligonucleotides and polypeptides. The system is capable of continuously synthesizing molecules by providing an array of reaction sites and an array of stations for carrying out synthetic manipulations. The reaction sites in the former array can be placed... Agent: Knobbe Martens Olson & Bear LLP

20070117180 - Enzyme producing plasma protein fragment having inhibitory activity to metastasis and growth of cancer and plasma protein fragment produced by fragmentation by said enzyme: An aspartic enzyme having a high homology with a cathepsin D precursor, which is a protein having the N-terminal amino acid sequence LVRIPLHKFT (SEQ ID NO: 1) and showing a molecular weight of about 45 kDa in non-reductive SDS electrophoresis and can degrade plasma proteins, typically plasminogen, to produce plasma... Agent: Birch Stewart Kolasch & Birch

20070117179 - In vitro protein synthesis systems for membrane proteins that include adolipoproteins and phospholipid-adolipoprotein particles: In vitro protein synthesis systems and methods are provided that produce membrane proteins in soluble form. In some aspects, the invention provides methods of synthesizing proteins using in vitro protein synthesis systems that include an apolipoprotein, in which higher yields of soluble protein are produced than in the absence of... Agent: Invitrogen Corporation C/o Intellevate

20070117177 - Nucleic acid-based matrixes for protein production: Various nucleic acid-based matrixes are provided, comprising nucleic acid monomers as building blocks, as well as nucleic acids encoding proteins, so as to produce novel biomaterials. Methods of utilizing such biomaterials include cell-free protein synthesis.... Agent: Wilson Sonsini Goodrich & Rosati

20070117176 - Process for the extraction of atelopeptide collagen from a collagenous source by microbial treatment: Bovine collagen is freed of non-collagen proteins, glycosaminoglycans and lipids by microbial treatment to yield a product, which is undenatured fibre of high tensile strength. The microbial extraction technique ensures degradation of non-collagenous components with the help of the protease combination produced, leaving the collagenous matter intact due to the... Agent: Meyertons, Hood, Kivlin, Kowert & Goetzel, P.C.

20070117183 - Corynebacterium glutamicum genes encoding metabolic pathway proteins: Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070117186 - Highly efficient secretory signal peptide and a protein expression system using the peptide thereof: This invention is directed to the identification of secretory signal peptides exhibiting higher secretion efficiency than conventional secretory signal peptides. Secretory signal peptides exhibiting higher secretion ability than the secretory signal peptides used in conventional membrane and secretory protein expression systems are identified and isolated from membrane proteins and secretory... Agent: Sughrue Mion, PLLC

20070117184 - In vivo incorporation of unnatural amino acids: The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.... Agent: Quine Intellectual Property Law Group, P.C.

20070117185 - Method for the recombinant expression of a polypeptide: A method for the recombinant production of a heterologous polypeptide in a eukaryotic host cell is described. The host cell comprises an expression plasmid, whereby the expression plasmid comprises in a 5′ to 3′ direction a) a promoter, b) a nucleic acid encoding a first polypeptide, whose amino acid sequence... Agent: Roche Palo Alto LLC Patent Law Dept. M/s A2-250

20070117181 - Non-natural labeled amino acid and method of constructing amino acid/trna complex: This invention relates to: a labeled amino acid that can be introduced into a protein with the aid of a protein synthesis system; a functional protein having functions derived from a label compound; a labeled amino acid comprising an aromatic ring bound to an amino acid side chain and a... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070117182 - Nucleic acids conferring transcriptional responsiveness on the rankl gene promoter and uses thereof: The present invention provides isolated nucleic acids containing functional polynucleotide sequences from the upstream region of the RANKL gene useful in conferring transcriptional responsiveness (e.g., vitamin D3 receptor complex responsiveness) on associated promoters and methods of using same to identify chemical entities capable of affecting transcriptional activity of the RANKL... Agent: Godfrey & Kahn, S.c.

20070117187 - Tools and methods useful in characterising the immunotoxic activity of xenobiotic substances: A method is described for the characterisation of a tested substance, particularly useful in the study of its toxicity, and in particular immunotoxicity. Also described are cell lines and nucleic acids useful in its procurement, which may be used to embody said method, particularly in obtaining cell-chip collections destined for... Agent: Cooper & Dunham, LLP

20070117188 - Natural, chimeric and hybrid glycosaminoglycan polymers and methods making and using same: The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella multocida, in order to create a variety of glycosaminoglycan oligosaccharides having a natural or chimeric or hybrid sugar structure.... Agent: Dunlap, Codding & Rogers P.C.

20070117189 - Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes: Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, their complementary sequences and their equivalent sequences, in particular nucleotide sequences displaying,... Agent: Oliff & Berridge, PLC

20070117190 - Delta-9 elongases and their use in making polyunsaturated fatty acids: The present invention relates to Δ9 elongases, which have the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA]. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ9 elongase along with methods of making long-chain polyunsaturated fatty acids (PUFAs) using these Δ9 elongases in... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070117192 - Production of 3-hydroxycarboxylic acid using nitrilase mutants: This invention relates to nitrilase mutants having improved nitrilase activity for converting 3-hydroxynitriles to 3-hydroxycarboxylic acids. More specifically, the Acidovorax facilis 72W (ATCC 55746) nitrilase gene was mutated using error-prone PCR and site-directed mutagenesis to create nitrilase enzymes having improved nitrilase activity for converting 3-hydroxynitriles (e.g., 3-hydroxybutyronitrile or 3-hydroxyvaleronitrile) to... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070117191 - Reductase gene for alpha-substituted-alpha, beta-unsaturated carbonyl compound: The present invention relates to: a reductase gene for an α-substituted-α,β-unsaturated carbonyl compound which contains a DNA sequence encoding an amino acid sequence represented by SEQ ID NO: 20 and an amino acid sequence represented by SEQ ID NO: 21; an enzyme which is a product of the gene; a... Agent: Sughrue Mion, PLLC

20070117193 - Method for producing lactic acid with high concentration and high yield using lactic acid bacteria: The present invention relates to a method for producing lactic acid with high concentration and high yield using Lactobacillus paracasei CJLA0310 KCCM-10542 that is separated and identified from Kimchi. Lactic acid is a very important organic acid with a wide range of applications including food additive such as food preservative,... Agent: Birch Stewart Kolasch & Birch

20070117194 - Method for preparing xylitol with high yield using recycling microorganism: Provided is a process for continuously producing xylitol in high yield and productivity using a vacuum microfiltration bioreactor containing a fermentation medium for a strain of the genus Candida, which includes: 5 300 g/l of xylose, 1 10 g/l of urea, 1 10 g/l of potassium diphosphate, 0.01 1 g/l... Agent: Fish & Richardson PC

20070117195 - Integrated thermochemical and biocatalytic energy production system: A method and apparatus for treating organic wastes is provided. Organic wastes are separated into high and low moisture content organic waste streams. The low moisture content organic waste stream is subjected to a gasification process and generates a producer gas. The high moisture content organic waste is subjected to... Agent: Bose Mckinney & Evans, LLP

20070117196 - Coffee mannanase: A DNA fragment derived from coffee encoding at least one enzyme involved in the hydrolysis of polysaccharides comprising pure or branched mannan molecules linked to each other via a β (1→4) linkage, and which has the the nucleic acid sequence SEQ ID NO.:1 or which is homologous to or hybridizes... Agent: Bell, Boyd & Lloyd LLP

20070117197 - Lactobacilli expressing biologically active polypeptides and uses thereof: The present invention relates to Lactobacillus species recombinantly altered to express a biologically active protein. The invention also related to methods of providing the bacteria to the vagina.... Agent: Townsend And Townsend And Crew, LLP

20070117198 - Industrial producing strain of the fungus claviceps purpurea (fr.) tul.: Disclosed are strains of fungus Claviceps purpurea (Fr.) Tul., that produce a high content of total ergot peptide alkaloids and/or an amount of beta-ergokryptine greater than the amount of alpha-ergokryptine during parasitic growth on a cereal.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20070117199 - Binding layer and method for its preparation and uses thereof: The invention provides a binding layer comprising a polysaccharide substituted by carboxylic groups or derivatives thereof exhibiting high performance in the binding of ligand molecules and in the interaction thereof with analyte molecules. A method for the preparation of the binding layer and for the assaying of various analyte molecules... Agent: Nath & Associates PLLC

20070117200 - Thermal cycler for pcr: An instrument for performing highly accurate PCR employing an assembly, a heated cover and an internal computer. The assembly is made up of a sample block, a number of Peltier thermal electric devices and heat sink, clamped together. The sample block temperature is changed exclusively by the thermoelectric devices controlled... Agent: Kilyk & Bowersox, P.l.l.c.

20070117201 - Plastic chip for pcr having on-chip polymer valve: The present invention relates to a plastic chip for PCR, having polymer valves, and more particularly to a plastic chip for PCR, having polymer valves, which can perform the temperature cycling of a small amount (nanoliter) of a sample in a microchamber at a constant temperature sensitively to temperature gradient.... Agent: Mckenna Long & Aldridge LLP

20070117202 - Novel nucleic acid molecule: The present invention is directed generally to an isolated nucleic acid molecule encompassing a neocentromere or a functional derivative thereof or a latent, synthetic or hybrid form thereof and its use inter alia in developing a range of eukaryotic artificial chromosomes including mammalian (e.g. human) and non-mammalian artificial chromosomes. Such... Agent: Scully Scott Murphy & Presser, PC

20070117204 - Culture substrate and culture method for undifferentiated cell and undifferentiated cultured cell: A culture substrate made of ceramics of any one or more of titania, alumina, zirconia, yttria, and carbon is used where minute pores having a pore diameter of from 0.1 μm to 10 μm are provided at least for a place to which a cell is seeded, and an undifferentiated... Agent: Foley And Lardner LLP Suite 500

20070117205 - Hepatoblasts and method of isolating same: This invention relates to methods of isolating hepatoblasts utilizing panning techniques and fluorescence activated cell sorting. This invention further relates to isolated hepatoblasts and to a method of treating liver dysfunction as well as to methods of forming artificial livers.... Agent: Foley And Lardner LLP Suite 500

20070117203 - Modulation of stem and progenitor cell growth by oscillatory fluid flow: Stem or progenitor cells, including cells derived from bone marrow, exhibit increased intracellular Ca2+ mobilization and alterations in gene expression and proliferation when subjected to an oscillatory fluid flow.... Agent: Bozicevic, Field & Francis LLP

20070117206 - Methods for clonal derivation of human blastocyst-derived stem cell lines: Human blastocyst-derived stem cells (hBS) or hBS derived cells, such as, e.g., cells of endothermal, mesodermal, and ectodermal origin, are pluripotent cells with widespread potentials within the areas of, e.g., therapeutic treatment, human developmental biology, and drug discovery processes. The present invention relates to a method for clonal derivation of... Agent: Buchanan, Ingersoll & Rooney PC

20070111191 - Storage of blood: A ribose-related compound is added to whole blood or packed red cells which have suboptimal function as measured by decreased levels of 2,3-DPG in order to rejuvenate the red blood cells to normal function as seen by raised levels of 2,3-DPG. Two representative ribose-related compounds are D-ribose and inosine.... Agent: Kathleen R. Terry

20070111199 - Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators: This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as... Agent: Kenyon & Kenyon LLP

20070111192 - Detection of protein interactions: The present invention relates to a method of detecting interactions, particularly peptide to peptide interactions, using fluorescence. Nucleic acids encoding fragments of fluorescent protein, a peptide of interest and a linker portion of different lengths interposed between the peptide of interest and a fragment of fluorescent protein is provided together... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070111194 - Method for the concentration and purification of biological compounds: The invention concerns materials and methods used for the concentration, desalination, purification or stabilization of biological compounds, in particular biological macromolecules and supramolecular structures, by means of superabsorbent polymers or superabsorptive composite materials.... Agent: Joyce Von Natzmer Hvp LLP

20070111198 - Nanopatterned surfaces and related methods for selective adhesion, sensing and separation: Nanodimensioned heterogeneous surface compositions and configurations, related systms ad methods for sensing particle or analyte interaction therewith.... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator

20070111197 - Sample analyzer and sample analyzing method: A sample analyzer comprising: a measurement section for measuring a sample of an animal; a memory for storing a measurement data by the measurement section; an analysis section for analyzing the measurement data stored on the memory in accordance with a first analysis condition corresponding to a previous setting of... Agent: Brinks Hofer Gilson & Lione

20070111193 - Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells: This invention provides methods and compositions for incorporation of an unnatural amino acid into a peptide using an orthogonal aminoacyl tRNA synthetase/tRNA pair. In particular, an orthogonal pair is provided to incorporate 5-hydroxy-L-tryptophan in a position encoded by an opal mutation.... Agent: Quine Intellectual Property Law Group, P.C.

20070111196 - Sterilization of biosensors: The present invention relates to methods of making a sterilized biosensor, where the biosensor comprises at least one binding reagent, which comprises at least one non-enzyme proteinaceous binding domain. Certain embodiments of the methods described herein comprise partially assembling the components of the biosensor, except for the binding reagent, and... Agent: David W. Highet Becton, Dickinson And Company

20070111195 - Toxicity typing using liver stem cells: This invention provides methods and systems for identifying and typing toxicity of chemical compositions, as well as for screening new compositions for toxicity. The invention involves detecting alterations in gene or protein expression and hence establishing molecular profiles in isolated mammalian LSCs contacted with various chemical compositions of known and... Agent: Morrison & Foerster LLP

20070111200 - Detection of hpv: The present invention provides compositions and methods for the detection and characterization of HPV sequences. More particularly, the present invention provides compositions, methods and kits for using invasive cleavage structure assays (e.g. the INVADER assay) to screen nucleic acid samples, e.g., from patients, for the presence of any one of... Agent: Medlen & Carroll, LLP

20070111202 - Electrochemical detection of nucleic acid sequences: An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential... Agent: Akerman Senterfitt

20070111201 - Reverse transfection of cell arrays for structural and functional analyses of proteins: The present invention relates to articles and methods for determining the function of genes, gene products, and nucleic acid products. The present invention also relates to identifying ligands and binding partners or proteins and nucleic acid products. The present invention also relates to methods and compositions related to reverse-transfection.... Agent: Cozen O'connor, P.C.

20070111214 - 20685, 579,17114, 23821, 33894 and 32613, novel human transporters: The present invention relates to newly identified human transporters. In particular, the invention relates to transporter polypeptides and polynucleotides, methods of detecting the transporter polypeptides and polynucleotides, and methods of diagnosing and treating transporter-related disorders. Also provided are vectors, host cells, and recombinant methods for making and using the novel... Agent: Intellectual Property Group Millennium Pharmaceuticals, Inc.

20070111249 - Automatic threshold setting for quantitative polymerase chain reaction: Disclosed are systems and methods for identifying and quantitating the presence of one or more DNA species in a sample population through PCR amplification. DNA species quantitation includes a determination of a threshold fluorescence value used in the assessment of the PCR amplification reaction. Various embodiments of the present invention... Agent: Kilyk & Bowersox, P.l.l.c.

20070111210 - Biomarkers for graft rejection: Methods are disclosed for diagnosing rejection in a transplanted subject, monitoring rejection in a transplanted subject at risk thereof, preventing, inhibiting, reducing or treating rejection in a transplanted subject, or identifying agents for use in the prevention, inhibition, reduction or treatment of rejection, based on genes which are differentially expressed... Agent: Novartis Corporate Intellectual Property

20070111232 - Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation: Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070111230 - Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport: Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070111215 - Customized oligonucleotide microchips that convert multiple genetic information to simpler patterns, are portable and reusable: This invention relates to using customize oligonucleotide microchips as biosensors for the detection and identification of nucleic acids specific for different genes, organisms and/or individuals in the environment, in food and in biological samples. The microchips are designed to convert multiple bits of genetic information into simpler patterns of signals... Agent: Barnes & Thornburg LLP

20070111240 - Cysteine variants of interleukin-11 and methods of use thereof: Disclosed are cysteine variants of interleukin-11 (IL-11) and methods of making and using such proteins in therapeutic applications.... Agent: Sheridan Ross PC

20070111235 - Detecting dna sequence variations: A method of analysing a polynucleotide target involves incubating the target with an oligonucleotide probe, generally an array of immobilised oligonucleotide probes, to form a duplex, and using ligase or polymerase to extend one chain of the duplex. A point mutation or variable number tandem repeat section may be analysed.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070111234 - Detection of biological dna: The present invention provides a method, a kit and a system for the analysis of samples with respect to the presence of biological DNA based on real-time polymerase chain reaction (PCR) in combination with an analyzing step. The method comprises the steps of performing a universal real-time PCR to amplify... Agent: Roche Diagnostics Operations Inc.

20070111231 - Detection of mutations in a gene associated with resistance to viral infection, oas2 and oas3: Compositions and methods are provided for detecting a mutation in a human oligoadenylate synthetase gene, particularly OAS2 or OAS3, wherein the mutation confers resistance to flavivirus infection, including infection by hepatitis C virus, and the mutation relates to other disease states including prostate cancer and diabetes, and uses of the... Agent: Davis Wright Tremaine, LLP

20070111243 - Detection of polyketide synthetase gene expression in karenia brevis: The present invention concerns an assay for the detection of polyketide synthetase (PKS) mRNA from the red tide dinoflagellate Karenia brevis. Another aspect of the invention concerns NASBA primers and a molecular beacon that enable detection of mRNA of one of the PKS genes. In another aspect, the present invention... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070111205 - Detection of somatic cells in milk: A simple, rapid and accurate method for detecting nucleic acids from milk are disclosed. The methods are useful in determining somatic cell count levels and diagnosing mastitis in cows.... Agent: Townsend And Townsend And Crew, LLP

20070111208 - Determination of free fractions: The invention relates to methods for the determination of pharmacological properties of substances, such as, e.g., chemical substances. The invention also relates to methods and kits for use in the determination of the free fraction, fu, of pharmaco-logically active compounds in aqueous solutions and serum. The invention also relates to... Agent: Jeffrey M. Greenman

20070111224 - Electrochemical sensor for detecting biomolecule, metthod of manufacturing the same, and method of detecting biomolecule using the same: Provided is a sensor for detecting a biomolecule, which includes: a substrate; a first material, immobilized on the substrate, having a cavity structure; a secondary material capable of selectively binding to the cavity structure of the first material and having electrochemical activity; and a probe biomolecule immobilized to the secondary... Agent: Cantor Colburn, LLP

20070111211 - Integrated viral complexes, methods of production thereof, vaccines containing same and methods of use thereof: Integrated viral complexes, methods of producing them, and their use as a vaccine against is described. Integrated viral complexes are optionally dried and may be stored at refrigeration temperatures. Integrated viral complexes include viable virions in intact cell membranes. The host cells are non-viable. The invention is advantageously employed in... Agent: Kenneth I Kohn Kohn & Associates

20070111209 - Inversion on chromosome 8p23 is a risk factor for anxiety disorders, depression and bipolar disorders: An association between psychiatric disorders and disorders comorbid with psychiatric disorders, and genetic markers in the 8p23 genomic region is described. Markers are also provided to diagnose or detect a susceptibility to disorders comorbid with panic disorder and independently of comorbidity with panic disorder. Methods and surrogate markers for detecting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070111218 - Label integrity verification of chemical array data: Methods, systems and computer readable media for checking label integrity of labeled biopolymers in a single sample assayed by chemical array analysis. At least first and second labels are incorporated into biopolymers in the single sample to produce a multi-labeled, single sample. The multi-labeled, single sample is hybridized with probes... Agent: Agilent Technologies Inc.

20070111219 - Label integrity verification of chemical array data: Methods, systems and computer readable media for checking label integrity of labeled biopolymers in a sample assayed by chemical array analysis. A sample is divided into equal aliquots. At least first and second labels are incorporated into biopolymers contained in first and second aliquots of the equal aliquots, respectively. The... Agent: Agilent Technologies Inc.

20070111223 - Method for detecting disease-associated mutations: A method is described for diagnosing individuals as having hypertrophic cardiomyopathy, e.g. familial or sporadic hypertrophic cardiomyopathy. The method provides a useful diagnostic tool which becomes particularly important when testing asymptomatic individuals suspected of having the disease. Symptomatic individuals have a much better chance of being diagnosed properly by a... Agent: Lahive & Cockfield, LLP

20070111206 - Method for diagnosis of tuberculosis by smear microscopy, culture and polymerase chain reaction using processed clinical samples and kit thereof: The present invention relates to a method of processing clinical samples for diagnosing bacterial infections by smear microscopy, culture or PCR as well as a kit for performing the said method. This invention also pertains to two sets of primers specific for the DevR gene of M. tuberculosis as well... Agent: The Webb Law Firm, P.C.

20070111242 - Method for producing novel dna sequences with biological activity: A method of obtaining an oligonucleotide capable of carrying out a predetermined biological function. A heterogeneous pool of oligonucleotides, x+y+z nucleotides in length, is first generated. Each oligonucleotide has a 5′ randomized sequence, x nucleotides in length, a central preselected sequence, y nucleotides in length, and a 3′ randomized sequence,... Agent: Bingham, Mccutchen LLP

20070111212 - Method of detecting nucleic acid and utilization thereof: It is intended to provide a method of detecting a nucleic acid whereby a target nucleic acid can be accurately and quickly detected at an elevated detection sensitivity compared with the existing methods; and a gene detection kit with the use of this method. A sample containing cells is fixed... Agent: Sheridan Ross PC

20070111221 - Method of preparation for pharmaceutical grade plasmid dna: This invention provides a process for the continuous alkaline lysis of a bacterial suspension in order to harvest pDNA. It further provides for optional additional purification steps, including lysate filtration, anion exchange chromatography, triplex affinity chromatography, and hydrophobic interaction chromatography. These optional purification steps can be combined with the continuous... Agent: Wiley Rein LLP

20070111226 - Method to quantify sirnas, mirnas and polymorphic mirnas: The present teachings provide methods, compositions, and kits for quantifying target polynucleotides. In some embodiments, a reverse stem-loop ligation probe is ligated to the 3′ end of a target polynucleotide, using a ligase that can ligate the 3′ end of RNA to the 5′ end of DNA using a DNA... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070111204 - Methods for detecting nucleic acid variations: The invention provides methods and diagnostic test kits for detecting target nucleic acid sequence variations in a sample. In particular, a plurality of oligonucleotide probe sets is provided. Each set has a target specific portion and a barcode. The target specific portions of the probes are suitable for ligation together... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070111238 - Methods for diagnosing and evaluating treatment of blood disorders: Methods, systems and kits are provided for the clinical staging of blood disorders including myelodysplastic syndrome, myeloproliferative diseases and leukemias by differential analysis of hematologic samples for the distribution of one or more hematopoietic stem or progenitor cell subsets. Additional functional, genetic, gene expression, proteomic or other molecular analyses of... Agent: Bozicevic, Field & Francis LLP

20070111203 - Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same: The present invention relates to methods for identifying compounds that modulate untranslated region-dependent expression of a target gene. The invention particularly relates to using untranslated regions of a target gene or fragments thereof linked to a reporter gene to identify compounds that modulate untranslated region-dependent expression of a target gene.... Agent: Jones Day

20070111216 - Methods for identifying polymerase inhibitors: The present invention relates to methods and compositions for the identification of enzyme inhibitors. In particular, the present invention relates to the identification of nucleic acid polymerase inhibitors.... Agent: Medlen & Carroll, LLP

20070111239 - Methods of using il-21: An allelic variation in the IL-21 receptor can result in reduced IFN-γ production in individuals and can require administration of different doses of IL-21 to achieve therapeutic effects seen individuals that do not have the allelic variant. Based on the genotype of a patient's IL-21 receptor allele, methods of predicting... Agent: Zymogenetics, Inc. Intellectual Property Department

20070111222 - Nucleic acid aptamer-based compositions and methods: The present invention relates to compositions that can detect the presence of specific entities or substances in an environment, and provide an amplified response to the detection as manifested by release of enzymes, reporter signals or drugs. The detection and response is based on nucleic acid functionalities, such as aptamer... Agent: Wilmerhale/columbia University

20070111248 - Nucleotide sequences specific to francisella tularensis and methods for the detection of francisella tularensis: Described herein is the identification of nucleotide sequences specific to Francisella tularensis that serves as a marker or signature for identification of this bacterium. In addition, forward and reverse primers and hybridization probes derived from these nucleotide sequences that are used in nucleotide detection methods to detect the presence of... Agent: John H. Lee Assistant Laboratory Counsel

20070111246 - Parametric calibration method: Method of preparing a calibration curve and determining the amount of an analyte polynucleotide present in a test sample, particularly using real-time amplification data. The method involves determining indicia of amplification for both the internal calibrator and analyte polynucleotide standards, each as a function of the amount of analyte polynucleotide... Agent: Gen Probe Incorporated

20070111207 - Partially double stranded nucleic acid molecules: A nucleic acid molecule for detecting a nucleic acid molecule is provided which is a partially double-stranded nucleic acid molecule consisting of (a) a single-stranded nucleic acid molecule complementary to the nucleic acid molecule to be detected and (b) one or two single-stranded nucleic acid molecules that hybridize with part... Agent: Birch Stewart Kolasch & Birch

20070111229 - Pathogenicity determinants which can be used as targets for developing means for preventing and controlling bacterial infections and/or systemic dissemination: The invention relates to a method for identifying and selecting a gene required for the proliferation in vivo of a pathogenic microorganism, comprising: using a strain of the pathogenic microorganism, generating mutants for inactivation in the genes encoding these factors, determining the virulence of these mutants on an expiremental model... Agent: Nixon & Vanderhye, PC

20070111245 - Predicting diabetic nephropathy: The invention relates to methods and compositions for identifying subjects who are predisposed to having diabetic nephropathy (DN).... Agent: Fish & Richardson PC

20070111233 - Prenatal diagnosis using cell-free fetal dna in amniotic fluid: The present invention relates to improved methods of prenatal diagnosis, screening, monitoring and/or testing. The inventive methods include the analysis by array-based hybridization of cell-free fetal DNA isolated from amniotic fluid. In addition to allowing the prenatal diagnosis of a variety of diseases and conditions, and the assessment of fetal... Agent: Choate, Hall & Stewart LLP

20070111213 - Primers, methods and kits for amplifying or detecting human leukocyte antigen alleles: The present invention describes primers, methods and kits for amplifying and identifying HLA alleles. Using these primers, all HLA alleles at a single locus can be amplified using either a multiplex or non-multiplex PCR approach. Within sets of the primers, control primer pairs may be used to produce control amplicons... Agent: Invitrogen C/o Intellevates Sughrue Mion PLLC

20070111250 - Probe carrier, method of producing the probe carrier, method of evaluating the probe carrier and method of detecting a target nucleic acid using the same: To provide probe carrier having a structure that a single-stranded DNA probe can be immobilized to a carrier effectively and forms of probe dots or spots immobilized to the carrier can be observed accurately by a scanning probe microscope or its derivative technology. A gold-containing film is formed in an... Agent: Fitzpatrick Cella Harper & Scinto

20070111237 - Process for identifying antigenized antibodies using ribosome cell free expression system: A process comprising (1) contacting a single-chain variable region (ScVr) mRNA library with a cell free ribosome expression system to produce a library of complexes each comprising a ribosome, an ScVr mRNA and a nascent single chain antigenized antibody encoded by the ScVr mRNA (ARM complexes) wherein the ScFv mRNA... Agent: Morgan, Lewis & Bockius, LLP

20070111217 - Quantitative trait locus prognostic for changes in regional adiposity and bmi in caucasian males: Caucasian males, but not females, presenting with statistically significant increases of L162V allelic SNP of the PPARα gene, relative to that of wild-type homozygotes, have an increased likelihood of increased regional adiposity (subcutaneous fat) and BMI, and are more likely to develop diseases associated with such changes, such as type... Agent: Dr. Melvin Blecher

20070111228 - Rna interference: The present invention relates to RNA interference and methods for selecting interfering RNAs. The present invention also relates to modified interfering RNAs. The present invention also relates to methods of reducing the level of a specific mRNA in a cell, methods for reducing the level of a specific protein in... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070111220 - Sensing phage-triggered ion cascade (septic): The present invention provides a method for detecting bacteria and a nano-well device having one or more input/output connections about a gap and one or more bacteriophages at or about the gap that trigger a detectable electrical field fluctuation when the one or more bacteriophages contact a cognate target within... Agent: Chalker Flores, LLP

20070111227 - Small regulatory rnas and methods of use: The present invention relates to unique small ribonucleic acid molecules, for example siRNAs and miRNAs, identified and isolated using MPSS. Specifically, the invention is directed to the identification of a library of unique small RNA sequences from Arabidopsis thaliana. In another aspect, the small RNA sequences themselves are useful for... Agent: Mccarter & English, LLP Basil S. Krikelis

20070111236 - Streptococcus suis vaccines and diagnostic tests: The invention relates to Streptococcus suis infection in pigs, vaccines directed against those infections and tests for diagnosing Streptococcus suis infections. The invention provides an isolated or recombinant nucleic acid encoding a capsular gene cluster of Streptococcus suis or a gene or gene fragment derived thereof. The invention further provides... Agent: Trask Britt

20070111241 - System and method for accessing, tracking, and editing sequence analysis and software to accomplish the same: The present invention relates to a system and method for accessing, tracking and editing sequence analysis and software to accomplish the same. The present invention includes embodiments that permit a party, for example a customer, to track the status of the samples (e.g., tissue, blood, or DNA) that the party... Agent: Greenberg Traurig, LLP

20070111225 - System and method for monitoring an analyte: The present invention provides for a monitoring system and method to monitor an analyte, including determining the presence of the analyte and analyzing the analyte; for example, cellular chorography and biological threats. The system and method use a fluidics apparatus (e.g., a flow cytometer), a computer, a probe synthesizer and/or... Agent: Davis Wright Tremaine LLP

20070111247 - Systems and methods for the biometric analysis of index founder populations: Systems, methods and apparatus for associating a clinical parameter with one or more candidate chromosomal regions in the human genome are provided. An index founder population is identified in a test population based upon the genotype X of each member of the test population such that the posterior probability Pr(K|X)... Agent: Jones Day

20070111244 - Tissue diagnostics for breast cancer: Disclosed are methods for diagnosing breast cancer in a cell sample by detecting an increase in the levels of expression of protein markers in the cell sample as compared to the levels of expression of the same protein markers in a normal, nonneoplastic breast cell sample. Also disclosed is a... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070111255 - Antibodies recognizing methyllysine, process for producing the same and utilization thereof: Antibodies capable of recognizing many types of proteins having methyllysine residues are established by immunizing an animal with a chemically methylated protein other than histone and subsequent screening or the like depending on the reactivity to a protein obtained by chemically methylating a protein other than the protein used in... Agent: Thompson Coburn, LLP

20070111261 - Antigens: The invention provides a method for identifying amino acid sequences in antigens of interest that are useful for evoking immune responses. The amino acid sequences have low sequence similarity to the host proteome and are predicted to bind to MHC. Also disclosed are HPV epitopes that evoke Class I or... Agent: Kenyon & Kenyon LLP

20070111260 - Cell display of antibody libraries: The present invention relates to a viral vector encoding for a library of antibodies or antibody fragments that are displayed on the cell membrane when expressed in a cell. The present invention provides cells comprising the viral vector nucleic acids and methods of screening the libraries for antibodies or antibody... Agent: Johnathan Klein-evans

20070111251 - Chemical address tags: The present invention provides methods and compositions related to the fields of chemoinformatics, chemogenomics, drug discovery and development, and drug targeting. In particular, the present invention provides subcellular localization signals (e.g., chemical address tags) that influence (e.g., direct) subcellular and organelle level localization of associated compounds (e.g., drugs and small... Agent: Medlen & Carroll, LLP

20070111258 - Compositions and methods for modulating the acute phase response: Methods and compositions are provided for modulating the acute phase response. In particular, methods and compositions are provided that inhibit the acute phase response, including expression or production of C-reactive protein (CRP). The invention accordingly has applicability to the modulation of innate immune responses and to cardiovascular diseases and disorders,... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070111259 - Human antibodies: The invention uses the power of display selection methods to screen libraries of human immunoglobulin genes from nonhuman transgenic animals expressing human immunoglobulins. Such screening produces unlimited numbers of high affinity human antibodies to any target of interest.... Agent: Townsend And Townsend And Crew, LLP

20070111257 - Improved protein expression comparison assay results and applications: The invention proves a method and means to produce protein expression comparison assay results and for using the improved protein expression comparison results for producing improved results for any other application which utilizes said improved protein expression results.... Agent: Wesley B. Ames

20070111252 - Marker peptide for alzheimer's disease: To provide a peptide obtainable by cleaving an N-terminal region and a C-terminal region of Alcadein α, Alcadein β, or Alcadein γ; and capable of being a diagnostic marker for Alzheimer's disease. It is possible to detect Alzheimer's disease at an early stage without burdening subjects to be tested by... Agent: Birch Stewart Kolasch & Birch

20070111254 - Method for diagnosing acute coronary syndrome: A bioaffinity assay for quantitative determination in a sample of free PAPP-A, defined as the pregnancy associated plasma protein A (PAPP-A) that is not complexed to the proform of major basic protein (proMBP), where free PAPP-A is determined either i) as a calculated difference between measured total PAPP-A and measured... Agent: James C. Lydon

20070111256 - Method for generating an artificially patterned substrate for stimulating the crystallation of a biomolecule thereon and method for stimulating the crystallization of biomolecules: It is the aim of the invention to provide a technology for the stimulation of the crystallization of biomolecules contained in a liquid solution that leads to significant improvements in the reliability of crystall growth processes and shortens the time and the number of attempts to grow a certain biomolecule... Agent: Siemens Schweiz Ag I-47, Intellectual Property

20070111253 - Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof: The present invention provides rhesus monkey dickkopf-1 (rhDkk-1) and nucleotide sequences encoding it. Also provided herein are recombinant vectors, and recombinant hosts comprising rhDkk-1-encoding nucleotide sequences. Isolated rhDkk-1 can be used to screen and identify novel osteoanabolic compounds that stimulate bone formation for the treatment of osteoporosis or other disorders... Agent: Merck And Co., Inc

20070111266 - Antibodies to murine zcytor17 ligand: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing... Agent: Zymogenetics, Inc. Intellectual Property Department

20070111263 - Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase c regulation: The present invention relates to a method for identification of a chemical compound which modulates the activity of mammalian GPI-PLC wherein a] a mammalian cell is incubated with glimepiride; b] hcDIGs of the cells of a] are prepared; c] the hcDIGs from b] are incubated with a chemical compound; d]... Agent: Ross J. Oehler Sanofi-aventis U.s. LLC

20070111264 - High throughput screening assay for the trpm5 ion channel: There exists a need in the art for high throughput screening assays that can identify compounds that specifically modulate the activity of fast-acting ion channels, such as TRPM5. Current methods suffer from a lack of sensitivity, low throughput, and are labor intensive. The claimed methods provide fluorescent assays with an... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070111265 - Ligands for mineralocorticoid receptor (mr) and methods for screening for or designing mr ligands: The inventors disclose a 1.95 Å crystal structure of the MR ligand binding domain containing a single C808S mutation bound to a corticosterone and the fourth LXXLL motif of steroid receptor coactivator-1 (SRC1-4). The inventors demonstrate that SRC1-4 is the most potent MR-binding motif and mutations that disrupt the MR/SRC1-4... Agent: Price Heneveld Cooper Dewitt & Litton, LLP

20070111262 - Method to assay test substances: Membrane proteins represent ˜30% of the proteome of both prokaryotes and eukaryotes. Unique to cell surface receptors is their biogenesis pathway, which involves vesicular trafficking from the endoplasmic reticulum through the Golgi apparatus and to the cell surface. Increasing evidence suggests specific regulation of biogenesis for different membrane receptors, hence... Agent: Banner & Witcoff, Ltd.

20070111267 - Method of determining efficacy of anticancer drug and determination kit therefor: A method of determining the efficacy of anticancer drug whereby accurate determination can be realized; and a determination kit therefor. In the determination of the efficacy of anticancer drugs, especially a tyrosine kinase inhibitor, Jab1 protein is used as an index of determination and the form of existence of Jab1... Agent: Sheridan Ross PC

20070111269 - Method to predict positive repeat prostate biopsy: A method and system for prognosis of prostate cancer in a patient after a negative biopsy.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20070111268 - Methods, compositions and kits for use in prognosis, characterization and treatment of cancer: The present invention provides methods, compositions and kits for the prognosis, characterization and treatment of cancers. The methods, compositions and kits of the invention comprise a set of markers whose expression is correlated with estrogen receptor beta function. Therefore, the methods, compositions and kits of the invention find particular use... Agent: King & Spalding LLP

20070111270 - Camp reporters and high throughput assays: cAMP reporters useful for obtaining measurements of cAMP levels with high spatial and temporal resolution and in high throughput assays.... Agent: Banner & Witcoff, Ltd.

20070111271 - Low molecular weight heparin assay, system and reagent therefor: A method, kit, system and reagent for measuring low molecular weight heparin in a whole blood sample is provided which involves the use of a Factor Xa activator, such as Russell's Viper Venom, as the coagulation assay initiator.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070111272 - Managing glycemia status in diabetic patients related application: Methods for monitoring and managing glycemia status in a diabetic patient are disclosed. The methods comprise measuring in a diabetic patient, serum concentrations of HbA1c, glucose and inorganic phosphate and comparing the measured concentrations with reference concentrations. An equation representing the reference relationship of HbA1c, glucose and inorganic phosphate is... Agent: Sonnenschein Nath & Rosenthal LLP

20070111273 - Protein-acrylamide copolymer hydrogels and method of using same to measure protein concentration and activity: Disclosed are a polyacrylamide-based method of fabricating surface-bound peptide and protein arrays, the arrays themselves, and a method of using the arrays to detect proteins and to measure their concentration, binding affinity, and kinetics. Peptides, proteins, fusion proteins, protein complexes, and the like, are labeled with an acrylic moiety and... Agent: Dewitt Ross & Stevens S.c.

20070111274 - Water-soluble tetrazolium compounds: wherein each of R1 to R19 independently represents hydrogen atom; nitro group; sulfonate group or alkyl, alkoxy, sulfoalkyl or sulfoalkyloxy groups having 1 to 4 carbon atoms; provided that each of at least two of R1 to R19 independently represents sulfonate group; or sulfoalkyl or sulfoalkyloxy groups having 1 to... Agent: Jay F Moldovanyi Fay Sharpe Fagan Minnich & Mckee

20070111275 - Method and apparatus for detecting phycocyanin-pigmented algae and bacteria from reflected light: The present invention relates to a method of detecting phycocyanin algae or bacteria in water from reflected light, and also includes devices for the measurement, calculation and transmission of data relating to that method.... Agent: Roger A. Gilcrest

20070111276 - Reagent and process for the identification and counting of biological cells: The invention relates to a reagent and a process for the identification and counting of biological cells in a sample. This reagent comprises a cell lysing agent selected from at least one detergent in a concentration capable of specifically lysing a given type of cells in the sample, and a... Agent: Connolly Bove Lodge & Hutz LLP

20070111277 - Identification of 3-ketosteroid 9-alfa-hydroxylase genes and microorganisms blocked in 3-ketosteroid 9-alfa-hydroxylase activity: The invention relates to an isolated polynucleotide sequence comprising a nucleic acid sequence encoding the amino acid sequence of KshA protein or of KshB protein, encoded by nucleotides 499-1695 of SEQ ID NO:1 or by nucleotides 387-1427 of SEQ ID NO:2, respectively, and functional homologues thereof. The polynucleotides of the... Agent: Akzo Nobel Inc.

20070111281 - Antigen binding molecules having modified fc regions and altered binding to fc receptors: The present invention is directed to antigen binding molecules, including antibodies, comprising a Fc region having one or more amino acid modifications, wherein the antigen binding molecule exhibits altered binding to one or more Fc receptors as a result of the modification(s). The invention is further directed to polynucleotides and... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070111280 - Compositions and methods for non-targeted activation of endogenous genes: The present invention is directed generally to activating gene expression or causing over-expression of a gene by recombination methods in situ. The invention also is directed generally to methods for expressing an endogenous gene in a cell at levels higher than those normally found in the cell. In one embodiment... Agent: Bernard C. Lasko

20070111287 - Design of beta-sheet proteins with specific binding properties: The present invention describes novel beta-sheet proteins having specific binding properties and catalytic properties and also methods for preparing these proteins.... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20070111278 - Endoglucanase stce and cellulase preparation containing the same: A novel endoglucanase derived from Staphylotrichum coccosporum, a polynucleotide encoding the endoglucanase, and a cellulase preparation containing the endoglucanase are disclosed. The endoglucanase or cellulase preparation is available for a washing use or fabric processing, such as a color clarification of a cellulose-containing fabric, a reduction of fuzz, an improvement... Agent: Sughrue Mion, PLLC

20070111284 - Galactosylation of recombinant glycoproteins: Enhanced glycosylation of glycoprotein expressed in host cells having enhanced CAD activity.... Agent: Merchant & Gould PC

20070111285 - Human skeletal muscle-specific ubiquitin-conjugating emzyme: The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and... Agent: Sughrue Mion, PLLC

20070111282 - Method to screen phage display libraries with different ligands: The invention provides a method for selecting, from a repertoire of polypeptides, a population of functional polypeptides which bind a target ligand in a first binding site and a generic ligand in a second binding site, which generic ligand is capable of binding functional members of the repertoire regardless of... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070111286 - Novel rat calcium channel subunits and related probes, cell lines and methods: Novel sequences for calcium channel α2δ-2 and α2δ-3 subunits are provided. Also provided are cell lines that express the novel calcium channel subunits of the invention. These cells may be used for identifying compounds capable of stimulating or inhibiting the activation of the calcium channels.... Agent: Morrison & Foerster LLP

20070111279 - Production of recombinant therapeutic bioscavengers against chemical and biological agents: This application provides a method to produce recombinant bioscavenger molecules to be used as human treatments to protect against toxicity resulting from exposure to chemical/biological agent toxins or drugs. This invention relates to the production of glycoproteins that exhibit poor stability in vivo and are thus inadequate as therapeutic treatments... Agent: Yvonne Rosonberg Apt 3

20070111283 - Vector system for selection of genes encoding secreted proteins and membrane-bound proteins: The subject invention concerns novel vectors for the rapid and robust selection for cDNA sequences that encode secreted or membrane-bound proteins. The invention also pertains to methods for cloning secreted or membrane-bound proteins, including proteins encoded by novel members of gene families.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070111288 - Media for clostridium bacterium: Animal product free (APF) media and processes for the culture and fermentation of botulinum toxin producing Clostridium botulinum bacteria. The botulinum toxin obtained can be used for formulating and compounding botulinum toxin pharmaceutical compositions. The APF media can contain significantly reduced levels of meat or dairy by-products and use non-animal... Agent: Allergan, Inc.

20070111289 - Immobilization of enzyme on a fibrous matrix: A multilayer enzyme immobilization process is provided comprising adsorbing a polyethyleneimine (PEI) solution in a fibrous matrix, and adding an enzyme to the fibrous matrix, which comprises a plurality of fibrils. The process further comprises forming at least two layers of PEI-enzyme aggregates on the fibrils, and cross-linking the multilayer... Agent: Dinsmore & Shohl LLP

20070111290 - Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070111291 - Coryneform bacteria which produce chemical compounds i: The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20070111292 - Structured lipid mixtures: (i) linear saturated acyl groups containing 6 to 12 carbon atoms or (ii) the acyl group of conjugated linoleic acid (CLA) and/or an omega-3 or omega-6 fatty acid (OF), with the proviso that the quantity of CLA acyl groups amounts to 3 to 50 mol-% and the quantity of OF... Agent: Cognis Corporation Patent Department

20070111293 - Genes from a gene cluster: ML-236B is an inhibitor of HMG-CoA reductase and useful in preparing another such inhibitor, pravastatin. The preparation of ML-236B using an ML-236B-producing microorganism is enhanced using a polynucleotide encoding a gene related to the polyketide synthase cluster occurring in such a microorganism.... Agent: Frishauf, Holtz, Goodman & Chick, PC

20070111294 - Methods and organisms for the growth-coupled production of succinate: The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions encoding an enzyme associated with growth-coupled production of succinate when an activity of the enzyme is reduced, whereby the one or more gene disruptions confers stable growth-coupled production of succinate onto the non- naturally occurring microorganism. Also... Agent: Mcdermott, Will & Emery

20070111295 - Method of producing baculovirus: The present invention is directed to a method for producing commercial quantities of Baculovirus using a combination of methods involving producing occlusion bodies with infectious baculovirus in caterpillar larvae and large numbers of viral particles with serial passages in cell culture. A two step method was developed by initially producing... Agent: Shoemaker And Mattare, Ltd

20070111296 - Methods and devices for quantitative viral assays: A method for quantifying infectious particles of a virus in a sample comprises providing a layer of host cells of the virus, contacting the layer of host cells with a preparation of the sample, and culturing the cells under conditions wherein the cells are submerged in a thin layer of... Agent: Baker Donelson Bearman Caldwell & Berkowitz, PC

20070111297 - Portable micro-flow managing system using infinitesimal pressure control: A micro-flow managing system is provided. The micro-flow managing system includes a pressure generator having a plurality of pressure chambers and a plurality of depressurizing chambers which generate respective set pressures; a valve kit having a plurality of selection valves, and a valve controller which control the selection valves to... Agent: Marshall, Gerstein & Borun LLP

20070111299 - Device and method for multiple analyte detection: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample.... Agent: Kilyk & Bowersox, P.l.l.c.

20070111300 - Device and method for multiple analyte detection: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample.... Agent: Kilyk & Bowersox, P.l.l.c.

20070111298 - Sample depositing device for a cell sorter: The invention relates to a sample depositing device, particularly for a cell sorter, comprising a sample supply (38, 39) for supplying samples to be deposited and comprising a sample storage element (36) for storing the samples. Said sample storage element (36) has a number of sample containers for storing the... Agent: The Law Office Of Randall T. Erickson, P.C.

20070111301 - Biological information inspection system: In a biological information inspection system capable of accumulating highly reproducible biological information in a plurality of inspection means and making a multifactorial analysis of related information, simplification and downsizing of the system is achieved. The biological information inspection system 10 of the present invention comprises a sensor chip 20... Agent: Buchanan, Ingersoll & Rooney PC

20070111302 - Compositions and methods for liquid metering in microchannels: The movement and mixing of microdroplets through microchannels is described employing microscale devices, comprising microdroplet transport channels, reaction regions, electrophoresis modules, and radiation detectors. Microdroplets are metered into defined volumes and are subsequently incorporated into a variety of biological assays. Electronic components are fabricated on the same substrate material, allowing... Agent: Peter G. Carroll Medlen & Carroll, LLP

20070111304 - Fluid handling apparatus and fluid handling unit for use therein: A fluid handling apparatus 10 has a plurality of fluid handling subassemblies 16, each of which is mounted in a corresponding one of mounting recessed portions 14 of a plate body 12. Each of the fluid handling subassemblies 16 includes: an injecting section 26 for injecting a fluid; a fluidized... Agent: Bachman & Lapointe, P.C.

20070111303 - Method and molecular diagnostic device for detection, analysis and identification of genomic dna: At least one exemplary embodiment of the invention is directed to a molecular diagnostic device that comprises a cartridge configured to eject samples comprising genomic material into a microfluidic chip that comprises an amplification area, a detection area, and a matrix analysis area.... Agent: Fitzpatrick Cella Harper & Scinto

20070111305 - Systems and methods for generating compost: Systems and methods for the generation of compost are provided. In one embodiment, the system for generating compost comprises an aeration floor having a plurality of gas flow apertures that connect to a network of gas flow channels, and a compost cover constructed of a gas and liquid impermeable fabric... Agent: Speckman Law Group PLLC

20070111307 - Method for preparing tissue constructs: The present invention relates to a method of assembling a single living tissue sheet formed of different cell populations. According to this invention at least two cell populations composing at least two living tissue sheets can be assembled into a single continuous tissue construct The cells of this construct can... Agent: Ogilvy Renault LLP

20070111306 - Systems and methods for selection and maintenance of homogeneous and pluripotent human embryonic cells: A number of human disorders are characterized by degeneration or loss of specific cells, resulting in pathology associated with reduction or absence of cell function. Such diseases include neurodegenerative diseases and diabetes. Methods are described for obtaining a substantially homogeneous population of undifferentiated human embryonic stem cells including incubating a... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20070111308 - Use of stem cells derived from dermal skin: The applications of this invention, the use of stem cells derived from the dermis, include but are not limited to cell differentiation, histiogenesis, organogenesis, cell therapy, tissue engineering, and tissue and organ regeneration.... Agent: Fish & Richardson PC

20070111309 - Vero cell line adapted to grow in suspension: A Vero cell line that can be grown in serum-free and protein-free culture and in suspension culture in the absence of supporting materials for its adherence, a process to obtain said Vero cell line and a process for producing viral vaccines with said cell line, a virus obtainable by said... Agent: Luis E. Arri

20070111310 - Pulse-medium perfusion bioreactor with improved mass transport for multiple-3-d cell constructs: Disclosed is a novel net member for supporting one or more cell constructs in the culture chamber of a bioreactor, which comprises an array of impermeable pyramidal elements protruding from the face thereof, wherein each of the corners of the base of each of said impermeable pyramidal elements comprises a... Agent: Kevin D Mccarthy Roach Brown Mccarthy & Gruber

20070111311 - Plant cells and plants with increased tolerance to environmental stress: This invention relates generally to transformed plant cells and plants comprising an inactivated or down-regulated gene resulting in increased tolerance and/or resistance to environmental stress as compared to non-transformed wild type cells and methods of producing such plant cells or plants. This invention further relates generally to transformed plant cells... Agent: Connolly Bove Lodge & Hutz, LLP

20070111312 - Method for the production of permanent human cell lines: The present invention relates to a method for the production of a permanent human cell line, wherein isolated primary human cells are transfected simultaneously with a sequence allowing the expression of at least one cell transforming factor and a sequence allowing the expression of at least one recombinant polypeptide.... Agent: Fulbright & Jaworski L.L.P.

20070105087 - Biological tissue processing substrate, processing apparatus, processing method and processing kit: A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface with the biological tissue, the porous body holding in pores an enzyme for obtaining the proteins or the degradation products of... Agent: Fitzpatrick Cella Harper & Scinto

20070105086 - Compositions and methods for identifying modulators of trpv2: It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a TRPV2.... Agent: Philip S. Johnson Johnson & Johnson

20070105085 - Crystal of a transporter-ligand complex and methods of use: The invention relates to the three-dimensional structure of a crystal of a transporter protein complexed with a ligand. The three-dimensional structure of the transporter-ligand complex is disclosed. The transporter-ligand crystal structure, wherein the ligand is an inhibitor molecule, is useful for providing structural information that may be integrated into drug... Agent: Sonnenschein Nath & Rosenthal LLP

20070105089 - Interactive transparent individual cells biochip processor: An Interactive Transparent Individual Cells Biochip Processor (ITICBP) device is described, which is useful for assessing a single, individual living cell at identifiable location or assessing group of cells each at identifiable location.... Agent: Martin D. Moynihan Prtsi, Inc.

20070105088 - Light scattering determination of treatment potencies: Potencies (44) of treatments effecting cells (11) are measured by difference (42) between angular intensity distributions of light scattered by treated cells and by untreated cells.... Agent: David J. Bremer

20070105090 - Amplification method: The present invention combines the use of template switching with nucleic acid amplification—such as PCR—to generate amplification products representative of an entire RNA population. An RNA polymerase promoter sequence allows transcription-based amplification to be performed on the derived amplification products such that antisense amplified RNA (aRNA) or complementary RNA (cRNA)... Agent: Morgan Lewis & Bockius LLP

20070105092 - Proteolytic and covalent antibodies: Improved methods for the production, selection and inhibition of catalytic and covalent antibodies are disclosed.... Agent: NeifeldIPLaw, PC

20070105091 - Real time assay for rotavirus: A highly sensitive quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) assay with wide linear dynamic range is useful as a high-throughput screening assay for detecting Rotavirus in clinical samples. The primers and probe specifically detect Rotavirus of all serotypes. The assay is particularly useful as a screening assay for determining... Agent: Merck And Co., Inc

20070105093 - Uncoupling of dna insert propagation and expression of protein for phage display: The present invention provides an advance in phage display technology by permitting the uncoupling of the propagation of phages containing inserted sequences encoding heterologous polypeptides from the expression of said polypeptides. The invention provides phage constructs and methods for their use to permit phage coat protein expression, and thus phage... Agent: Wilson Sonsini Goodrich & Rosati

20070105094 - Water-soluble cationic magnetic fine particles and method for separating or detecting lipid vesicle using the same: A phospholipid vesicle such as a virus is to be rapidly separated (concentrated, roughly purified) and good detection (diagnosis) results can be obtained with suppressing inhibition of virus-denature, PCR inhibition, latex-aggregation inhibition, and the like. Moreover, the above operations are to be automated. A phospholipid vesicle is separated using a... Agent: Greenblum & Bernstein, P.L.C

20070105103 - Array having substances fixed on support arranged with chromosomal order or sequence position information added thereto, process for producing the same, analytical system using the array and use of these: In fabricating various types of arrays such as a micro array, different kinds of biosubstances, or synthetic substances interacting with the biosubstances, are arranged and immobilized on a support such that the chromosomal order of base sequence blocks, corresponding to the biosubstances, is ascertainable. The biosubstances may be nucleic acids... Agent: Sheridan Ross PC

20070105137 - Biomarkers for toxic algae: The present invention is directed toward biomarkers that identify characteristics of algae. The invention is further directed toward biomarkers that serve to identify algae species and strains of algae species as well as detect the presence of algal toxins. Additional embodiments feature methods utilizing algal biomarkers and polypeptides that can... Agent: Knobbe Martens Olson & Bear LLP

20070105114 - Biomarkers of cyclin-dependent kinase modulation: Biomarkers having expression patterns that correlate with a response of cells to treatment with one or more cdk modulating agents, and uses thereof. Also provided are methods for testing or predicting whether a mammal will respond therapeutically to a method of treating cancer that comprises administering an agent that modulates... Agent: Louis J. Wille Bristol-myers Squibb Company

20070105135 - Charged compounds comprising a nucleic acid binding moiety and uses therefor: Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing... Agent: Townsend And Townsend And Crew, LLP

20070105125 - Chemical array housing having a gas delivery element and methods of using the same: Chemical array housings configured for use with chemical array readers are provided, where the housings include at least one chemical array holding element and a gas delivery element. Aspects of the invention include positioning a chemical array in the housing and introducing a gas into the housing. Also provided are... Agent: Agilent Technologies Inc.

20070105130 - Compositions and methods for the treatment of cancer: Disclosed herein are methods and compositions for the treatment of cancer. In particular, the present invention discloses inhibitors of the Fanconi anemia pathway and methods using same. Such inhibitors are useful in inhibiting DNA damage repair and can be useful, for example, in the treatment of cancer.... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070105133 - Compositions and methods for treating and diagnosing cancer: The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor... Agent: Medlen & Carroll, LLP Suite 350

20070105128 - Detection of genetic polymorphisms: The present invention relates to genetic polymorphism data, compositions and methods for detecting genetic polymorphisms, methods for evaluating drugs using genetic polymorphisms and screening methods for drugs.... Agent: Medlen & Carroll, LLP Suite 350

20070105146 - Detection of susceptibility to autoimmune diseases: The present invention provides methods and reagents for determining sequence variants present at the IL4 receptor, IL-4 and IL-13 loci, which facilitate identifying individuals at risk for type 1 diabetes.... Agent: Townsend And Townsend And Crew, LLP

20070105126 - Device for monitoring polymerase chain reactions: A method for calibrating temperature can include cycling temperatures of a set of wells, wherein each well of the set comprises a sample with a spectrally distinguishable species. The method can further include measuring a signal from the spectrally distinguishable species for each well at a temperature during a first... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070105104 - Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor ltb4 (ltb4): The invention provides a human LTB4 which is associated with the cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of... Agent: Banner & Witcoff, Ltd.

20070105134 - Efficacy of calcimimetic agents: A method of assessing the efficacy of a calcimimetic drug to treat hyperparathyroidism in a subject may include determining which alleles for a calcium-sensitive receptor (CaSR) gene the subject carries; and concluding that the calcimimetic drug will have a first or highest efficacy if the subject has a 990Gly-990Gly genotype,... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070105096 - Endocrine cell lines and methods of using same: In accordance with the present invention, there are provided (1) various cell lines derived from hypothalamus and Langerhans islets of mammals, (2) process for producing an active peptide and expression cloning system of active peptide precursor gene using the cell line as a host, (3) a method of screening or... Agent: Nixon & Vanderhye, PC

20070105139 - Fluorescent probe and fluorescence detecting method: A fluorescent probe having a base sequence complementary to a specific sequence in a target nucleic acid, wherein the fluorescent probe has one end labeled with a nano particle fluorescent material, and the other end labeled with a fluorescent dye capable of fluorescence resonance energy transfer from the nano particle... Agent: Birch Stewart Kolasch & Birch

20070105101 - Gene expression associated with osteobla st differentiation: The present invention identifies genes whose expression pattern is altered when pre-osteoblastic cells undergo differentiation into mature osteoblasts. The genes identified may be used as markers for the differentiation process. The present invention also provides methods to screen agents that are capable of modulating the differentiation process. The present invention... Agent: Novartis Corporate Intellectual Property

20070105140 - In vivo production of cyclic peptides: The present invention relates to methods and compositions utilizing inteins to generated libraries of cyclic peptides in vivo.... Agent: Bozicevic, Field & Francis LLP

20070105123 - Ire-1alpha substrates: IRE-1α substrates useful for identifying agonists and antagonists of IRE-1α RNase activity.... Agent: Banner & Witcoff, Ltd.

20070105098 - Isolation and use of ryanodine receptors: The genes encoding ryanodine receptor homologs have been characterized from multiple insect families including lepidopteran tobacco budworm (Heliothis virescens), homopteran green peach aphid (Myzus persicae), corn plant hopper (Peregrinus maidis), cotton melon aphid (Aphis gossypii) and fruitfly (Drosophila melanogaster). The full-length genes have been isolated, cloned and amplified in bacterial... Agent: E I Du Pont De Nemours & Company

20070105112 - Laccases, nucleic acids encoding them and methods for making and using them: The invention provides laccases, polynucleotides encoding these enzymes, the use of such polynucleotides and polypeptides. In one aspect, the invention relates to the enzymatic production of nootkatone by way of the conversion of valencene using proteins having a laccase activity, e.g., a novel laccase of the invention. In one aspect,... Agent: Diversa C/o Mofo S.d.

20070105107 - Marker assisted best linear unbiased prediction (ma-blup): software adaptions for large breeding populations in farm animal species: The invention provides methodologies for improved molecular genetic analysis of individual animals and animal populations. The invention includes methods and systems for identifying those animals in a population that are most likely to heritably pass on desirable traits. Provided are means for evaluating the estimated breeding values and increasing the... Agent: Howrey LLP

20070105116 - Metal complex type nucleic acid: An object of the present invention is to provide a novel structure that enables one-dimensional arraying of metal atoms and can stably exist. The present invention relates to a double-stranded oligonucleotide derivative, which contains two oligonucleotide derivatives each containing at least one nucleotide derivative wherein a base portion of a... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070105097 - Method for comparing gene expression level: The present invention relates to a method for comparing and determining the gene expression level, which is very important in disease-related gene screening, early clinical diagnosis and medicine development. The present invention utilizes quantitative characteristics of bioluminescence analysis to compare gene expression levels of different individuals or samples in order... Agent: Suiter West Swantz PC Llo

20070105119 - Method for detecting analytes by means of an analyte/polymeric activator bilayer arrangement: The invention relates to the field of analytical sensors. In particular, the invention relates to a method for the detection of analytes in a sample by means of an electrode arrangement, which is characterized by the formation of a conductive bilayer of analytes and an agent for increasing the conductivity... Agent: Intellectual Property / Technology Law

20070105102 - Method for detection and characterization of pre-malignant transformation: Methods are provided for estimating the risk of developing melanoma and related malignancies in an individual. Methods and compositions for diagnosing, treating, and preventing melanoma and related malignancies also are provided.... Agent: Heller Ehrman LLP

20070105138 - Method for detection of a target nucleic acid with a fen nuclease: The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by incubating a sample comprising a target nucleic acid with a probe. The invention also includes the steps of... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070105118 - Method for distinguishing aml subtypes with recurring genetic aberrations: Disclosed is a method for distinguishing AML subtypes with recurring genetic aberrations t(8;21), t(15;17), t(11q23)/MLL, inv(3)/t(3;3), inv(l6), AML_komplext, trisomy 8 sole, trisomy 11 sole, trisomy 13 sole, monosomy 7 sole, del(5q) and/or del(9q) in a sample by determining the expression level of markers, as well as a diagnostic kit and... Agent: Roche Molecular Systems Inc Patent Law Department

20070105117 - Method for in vitro evolution of polypeptides: The invention relates to a method for the production and allocation of nucleic acids and polypeptides coded thereby. Said method can be used for evolutionary selection of polypeptides in vitro. The inventive method makes it possible to allocate nucleic acids to the polypeptides coded thereby and to select and isolate... Agent: Nath & Associates

20070105127 - Method for producing modified glycoproteins: Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower... Agent: Merck And Co., Inc

20070105111 - Method for structuring a substrate surface: In a method for structuring the surface of a substrate, a substrate is elastically expanded by the application of a tensile stress so that a surface area of the substrate in which a structure is to be created, is enlarged. Then, in the surface area, a structure is produced that... Agent: The Webb Law Firm, P.C.

20070105121 - Method for the detection of schizophrenia related gene transcripts in blood: The present invention is directed to detection and measurement of gene transcripts and their equivalent nucleic acid products in blood. Specifically provided is analysis performed on a drop of blood for detecting, diagnosing and monitoring diseases using gene-specific and/or tissue-specific primers. The present invention also describes methods by which delineation... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070105120 - Method of identifying/designing and/or modifying chemical species capable of interacting with a physiologically active macromolecule: The present invention relates to a method of identifying/designing and/or modifying species capable of interacting with a protein molecule that is a potential drug target.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070105144 - Method of nucleic acid analysis: It is intended to provide a method of efficient, high-precision quantitative analysis of a gene region with plural possible sequences by simultaneously separating and detecting standard and measurement nucleic acids overlapping in their detection times. The present invention provides a method of quantitative analysis of a gene region with plural... Agent: Mcdermott Will & Emery LLP

20070105124 - Methods and kits for nucleic acid amplification: Compositions and methods are provided for amplifying nucleic acid molecules. The nucleic acid molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays.... Agent: Datascope Investment Corp.

20070105106 - Methods and reagents for quantitative analysis of dehalococcoides species: The invention sets forth specific probes and primer pairs for such quantitative analysis and methods of obtaining template DNA from the Dehalococcoides species of interest. These techniques are useful in a bioremediation process to monitor and control the dechlorination of chlorinated hydrocarbons.... Agent: Darby & Darby P.C.

20070105136 - Methods for identifying, diagnosing, and predicting survival of lymphomas: Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis... Agent: Perkins Coie LLP

20070105142 - Methods for prognosis and monitoring cancer therapy: The present invention also relates to biomarkers and the use of biomarkers for the prediction and prognosis of cancer as well as the use of biomarkers to monitor the efficacy of cancer treatment. Specifically, this invention relates to the use of HER-2, EGFR, VEGF, u-PA, p-PAI-1, and soluble forms thereof,... Agent: Millen, White, Zelano & Branigan, P.C.

20070105113 - Methods of degrading dsrna and synthesizing rna: A protein having an activity of degrading a dsRNA, namely, being capable of acting on a long-chain dsRNA to form a dsRNA of a definite length; a method of efficiently preparing a dsRNA of a definite length which comprises treating a dsRNA with the protein having an activity of degrading... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070105145 - Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation: This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.... Agent: Applied Biosystems

20070105110 - Mutation associated with strokes: The present invention relates to a method of identifying a subject predisposed to ischemic stroke. The method includes the step of identifying a mutation in the subject that reduces the release rate of tissue plasminogen activator.... Agent: Birch Stewart Kolasch & Birch

20070105143 - Novel bhlh type transcription factor genes: Human- and mouse-derived bHLH type transcription factors were isolated. These transcription factors shared homology with the transcription factor DEC1, the expression of which is induced in human cartilage cells when differentiated with cAMP. Thus, these isolated transcription factors are thought to be novel transcription factors belonging to the DEC1 subfamily.... Agent: Fish & Richardson PC

20070105099 - Nucleic acid amplification using non-standard bases: The present invention provides methods, kits and compositions for high fidelity nucleic acid amplification reactions of target nucleic acids such that specific amplification products that incorporate non-standard bases are produced. The amplification reactions can either be linear or exponential. In some embodiments, the fidelity of the amplification reaction is high... Agent: Eragen Biosciences, Inc. C/o Foley & Lardner LLP

20070105132 - Nucleic acid sequencing by raman monitoring of uptake of nucleotides during molecular replication: The methods and apparatus disclosed herein are useful for detecting nucleotides, nucleosides, and bases and for nucleic acid sequence determination. The methods involve detection of a nucleotide, nucleoside, or base using surface enhanced Raman spectroscopy (SERS). The detection can be part of a nucleic acid sequencing reaction to detect uptake... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper Rudnick Gray Cary US LLP

20070105108 - Polynucleotides capable of target-depedent circularization and topological linkage: The invention provides allosterically regulatable polynucleotides capable of target-dependent circularization and topological linkage to a target nucleic acid molecule. Polynucleotides of the invention include a target binding sequence and a regulatory element which prevents circularization in the absence of the target binding. Polynucleotides may include a catalytic domain, allowing circularization... Agent: Morrison & Foerster LLP

20070105122 - Primers for synthesizing full-length cdna and their use: Primers for synthesizing full-length cDNAs and their use are provided. 5602 cDNA encoding a human protein has been isolated and nucleotide sequences of 5′-, and 3′-ends of the cDNA have been determined. Furthermore, primers for synthesizing the full-length cDNA have been provided to clarify the function of the protein encoded... Agent: Foley And Lardner LLP Suite 500

20070105100 - Process for assay of nucleic acids by competitive hybridization using a dna microarray: A process for rapid and simple assay of nucleic acid on the basis of competitive hybridization using a DNA microarray that comprises a step of hybridizing a labeled nucleic acid other than the target nucleic acid with one of the immobilized probes on the substrate, where the labeled nucleic acid... Agent: Fitzpatrick Cella Harper & Scinto

20070105095 - Process for detecting predisposition to a cardiovascular disease: Includes the identification in the genetic material of an isolated biological sample from said human an allelic variant which consist on the substitution of a cytosine by an tymine in the position 46 over the transcriptional origin of Factor XII (46C/T) within the locus of chromosome 5, limited by the... Agent: Fay Kaplun & Marcin, LLP

20070105115 - Promoter of the human fatp5 gene and uses: The invention relates to an isolated human nucleic acid, characterized in that it corresponds to the promoter of the human FATP5 protein, and to an isolated human nucleic acid coding for a protein, particularly for the human FATP5 protein, placed under the dependence of said promoter. The invention further relates... Agent: Millen, White, Zelano & Branigan, P.C.

20070105147 - Rapid method for screening compounds for in vivo activity: The present invention provides a rapid method for screening potentially pharmaceutically useful compounds for activity in vivo. The method has the steps of growing a target cell into which a reporter gene was introduced in a biocompatible, semipermeable encapsulation device; implanting the semi-permeable encapsulation device into a subject; administering a... Agent: Novartis Corporate Intellectual Property

20070105131 - Sequencing of surface immobilized polymers utilizing microfluorescence detection: Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal monomers are used to label polymers at defined positions on a solid... Agent: Townsend And Townsend And Crew LLP

20070105109 - Sirt1 and genetic disorders: Alzheimer's Disease (AD) is genetically linked to a locus that includes the SIRT1 gene. This disclosure includes methods and compositions for evaluating genetic variances, e.g., within this locus, and for the association of these variances with AD. The disclosure also includes methods and compositions for modulating SIRT1 expression and/or activity.... Agent: Fish & Richardson PC

20070105129 - Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories: The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the common bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection... Agent: Knobbe Martens Olson & Bear LLP

20070105148 - Sphingosine 1-phosphate receptor gene, sppr: A novel sphingosine 1-phosphate receptor gene, herein termed sppr, and its splice variants. Sppr is up-regulated in LGL and is useful, for example, in the diagnosis and treatment of certain lymphoproliferative, neurodegenerative and autoimmune diseases.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070105105 - Surrogate cell gene expression signatures for evaluating the physical state of a subject: The present invention relates to non-invasive and minimally invasive techniques for evaluating the physical state of a subject, including diagnosing a disease, disorder, or physical state of the subject, determining the prognosis of the subject, determining a subject's susceptibility for a disease, disorder, or physical state and determining, developing and... Agent: Darby & Darby P.C.

20070105141 - Use of azetidinone compounds: The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070105149 - Assay for diabetes: An assay for testing a subject for diabetes or a predisposition to diabetes including analysing a biological fluid from a subject for the presence of one or more proteins selected from the group consisting of Alpha 2 macroglobulin, Apolipoprotein All, Immunoglobulin alpha heavy chain constant region, Immunoglobulin mu chain C... Agent: Barnes & Thornburg LLP

20070105154 - Cell lysis composition, methods of use, apparatus, and kit: Cell lysis compositions, methods for extracting and isolating proteins and peptides from a host cells using the compositions, kits and apparatus for extracting and isolating protein and peptide molecules from host cells and for detecting for the presence of a protein or peptide. The composition allows for the extraction and... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070105153 - Human gene critical to fertility: Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for using... Agent: Klarquist Sparkman, LLP

20070105150 - Method for cell surface display of target proteins using fadl of e.coli: The present invention relates to an expression vector which can effectively express target proteins or peptides on the surface of cells using an outer membrane protein (FadL) of E. coli as a surface anchoring motif. Also, the present invention relates to microorganisms transformed with the expression vector, and a method... Agent: Intellectual Property / Technology Law

20070105152 - Methods for determining protein binding specificity using peptide libraries: A method for determining protein binding specificity using a screen of a peptide library is provided. The method can be used to determine binding specificity for human NAD+-dependent deacetylase SIRT1, and to identify the most efficiently deacetylated peptide sequences. The method can be also used to screen a combinatorial H4... Agent: Brinks Hofer Gilson & Lione

20070105156 - Plasma or serum separation membrane and filter apparatus including the plasma of serum separation membrane: A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or... Agent: Law Office Of Townsend & Banta C/o Portfolioip

20070105155 - Polypeptide complex of trpm8 and calmodulin and its uses thereof: The present invention discovered that a mammalian TRPM8 binds to calmodulin. The present invention provides a polypeptide complex comprising a cold-menthol receptor (TRPM8) or an active fragment or derivative of TRPM8 and a calmodulin or an active fragment or derivative of calmodulin, and the uses of the polypeptide complex.... Agent: Philip S. Johnson Johnson & Johnson

20070105151 - Small molecule transcriptional activation domains: The present invention relates to gene regulation. In particular, the present invention provides small molecule activation domain compositions and methods of making the same. The present invention further provides methods of regulating gene expression using the novel activation domains. The invention also provides methods of screening small molecule/compound libraries for... Agent: Medlen & Carroll, LLP

20070105160 - Detection of intracellular enzyme complex: Methods and compositions are provided for determining intracellular translocation of proteins employing β-galactosidase fragments that independently complex to form an active enzyme. Cells are used having two fusion constructs: one fragment bound to a protein of interest; and the other fragment bound to a compartment localizing signal. The cells are... Agent: Peters Verny , L.L.P.

20070105159 - Mammalian t1r3 sweet taste receptors: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of... Agent: Fenwick & West LLP

20070105157 - Method and apparatus for signal transduction pathway profiling: An assay device for determining the presence of analytes in a cell lysate comprises a porous support member and a plurality of binding reagents arranged and immobilized at multiple reaction sites on the support member. The binding reagents are selected and arranged to assess the status of a selected cellular... Agent: Fay Sharpe LLP

20070105161 - Methods of identifying compounds that inhibit notch cleavage: In vitro cell-based methods for identifying compounds that inhibit Notch cleavage and methods for identifying γ-secretase inhibitors that exhibit reduced induction of goblet cell metaplasia are provided. Also provided are methods of identifying compounds that inhibit cleavage of γ-secretase substrates other than Notch and homogeneous compositions or cultures of Notch-expressing... Agent: Louis J. Wille Bristol-myers Squibb Company

20070105158 - Recombined cell system for deorphanizing g protein-coupled receptors: The present invention relates to a recombinant cellular system, comprising an animal host cell, comprising a recombinant G protein-coupled specific receptor, and the recombinant Ca2+ specific channel CNGA2. The invention furthermore relates to a method for producing the cellular system according to the invention and the use of the system... Agent: Norris, Mclaughlin & Marcus

20070105164 - Cancer diagnosis and therapy: The invention relates to an oncofetal glycoprotein, referred to as MQ-1, nucleic acid sequences coding for the protein, and antibodies which bind specifically to the protein. Also described is a hybridoma capable of producing monoclonal antibodies which bind specifically to the protein of the invention. Methods, and kits, for diagnosing... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070105165 - Composite profiles of cell antigens and target signal transduction proteins for analysis and clinical management of hematologic cancers: The present invention is directed to methods for establishing a composite marker profile for a sample derived from an individual suspected having a neoplastic condition. A composite marker profile of the invention allows for identification of prognostically and therapeutically relevant subgroups of neoplastic conditions and prediction of the clinical course... Agent: Beckman Coulter, Inc.

20070105166 - Non-invasive enzyme screen for tissue remodelling associated conditions: Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of metastatic cancer by the identification of high molecular... Agent: Goodwin Procter LLP Patent Administrator

20070105168 - Diagnosis and prevention of fetal heart disease: The present invention relates to a method for assessing the likelihood of the presence or formation of fetal heart disease (such as HLHS) in a fetus. In this methodology, the mother, either before or during pregnancy, is tested for the presence of anti-strep antibodies. If positive, the fetus is evaluated... Agent: Frost Brown Todd, LLC

20070105167 - Virulence associated nucleic acid sequences and uses thereof: Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e.g., DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds.... Agent: Clark & Elbing LLP

20070105163 - Flow-controlled magnetic particle manipulation: Inventive methods and apparatus are useful for collecting magnetic materials in one or more magnetic fields and resuspending the particles into a dispersion medium, and optionally repeating collection/resuspension one or more times in the same or a different medium, by controlling the direction and rate of fluid flow through a... Agent: Douglas E. Mckinley, Jr.

20070105162 - Monovalent avidin and streptavidin compositions: The invention relates, in part, to monovalent avidin and streptavidin compositions. The invention also relates to methods of preparing and using monovalent avidin and streptavidin compositions. In some aspects of the invention, the compositions are monovalent avidin or monovalent streptavidin with a single femtomolar biotin-binding site.... Agent: Wolf Greenfield & Sacks, PC

20070105170 - Extracorporeal diagnostic: The present invention provides an extracorporeal diagnostic used for measurement of a substance to be tested in a specimen. The extracorporeal diagnostic comprises a reagent which specifically binds to the substance to be tested, and a hydrophilic material (a sugar or a sugar derivative). More particularly, the present invention relates... Agent: Snell & Wilmer L.L.P. (matsushita)

20070105171 - Human protease molecules: The invention provides human protease molecules (HUPM) and polynucleotides which identify and encode HUPM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HUPM.... Agent: Merchant & Gould PC

20070105169 - Secreted polypeptide species associated with cardiovascular disorders: The invention discloses human secreted polypeptides that circulate at an increased level in the plasma of patients with cardiovascular disorders. The invention also provides methods of using compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for these polypeptides, for diagnosis, prognosis, and treatment of cardiovascular disorders.... Agent: Novartis Corporate Intellectual Property

20070105172 - Multiple gene transcription activity assay system: A gene construct incorporating any of at least two luciferase genes which emit lights with different colors using an identical substrate such that the gene can be stably expressed in mammalian cells.... Agent: Knobbe Martens Olson & Bear LLP

20070105176 - Method and apparatus for glucose monitoring: This disclosure relates to systems, devices, and methods of sensing an analyte. An implantable sensor may be contacted with a test sample under conditions that permit a binding protein and a ligand of the sensor to interact in an analyte-dependent manner to produce an analyte-dependent signal, and (b) detecting the... Agent: Baker Botts L.L.P.

20070105175 - Method for improving heat stability of composition containing water-soluble coenzyme-bound glucose dehydrogenase (gdh): The invention relates to a method for improving the heat stability of glucose dehydrogenase (GDH), comprising a step of combining, in a composition comprising soluble coenzyme-bound glucose dehydrogenase (GDH), the enzyme with any one or more selected from the group consisting of sugar alcohols, carboxyl group-containing compounds, alkali metal-containing compounds,... Agent: Leydig Voit & Mayer, Ltd

20070105173 - Modified pyrroloquinoline quinone (pqq) dependent glucose dehydrogenase excellent in substrate specificity: PQQGDH having an improved substrate specificity or having an improved specific activity in an assay system using ferricyanide ion as a mediator is provided. Modified PQQGDH having the enhanced substrate specificity by introducing an amino acid mutation in a particular region of PQQGDH, and a method of enhancing the specific... Agent: Leydig Voit & Mayer, Ltd

20070105174 - Novel glucose dehydrogenase: The invention relates to a eukaryote-derived glucose dehydrogenase that retains, after being heat-treated in a liquid state at 55° C. for 15 minutes, at least 90% of its activity before the heat treatment; a process for producing the glucose dehydrogenase, comprising the steps of culturing a eukaryotic microorganism and extracting... Agent: Leydig Voit & Mayer, Ltd

20070105178 - Human proteins responsible for nedd8 activation and conjugation: The invention relates to covalent modification of proteins through their conjugation with other proteins. More particularly, the invention relates to the modulation of such conjugation involving the protein NEDD8. The invention provides compositions and methods for detecting and/or modulating the activation and/or conjugation of NEDD8, as well as compositions and... Agent: Millennium Pharmaceuticals, Inc.

20070105177 - Method for detecting analyte in sample, method for quantifying activity of enzyme, and method for quantifying protein in sample: A method for detecting an analyte in a sample is described herein. The method comprises: preparing a complex immobilized solid phase comprising a solid phase and a complex on the solid phase; the complex comprising an analyte and a signal emitting substance; treating the complex immobilized solid phase with a... Agent: Sughrue Mion, PLLC

20070105179 - Methods of detecting n-and o-linked oligosaccharides in glycoproteins: Methods for removing N-linked and O-linked oligosaccharides from a glycoprotein including N-linked and O-linked oligosaccharides are provided. N-linked oligosaccharides are enzymatically cleaved from a glycoprotein to form cleaved-off N-linked oligosaccharides and residual glycoprotein. Residual glycoprotein is immobilized on a solid substrate. The cleaved-off N-linked oligosaccharides are separated from the residual... Agent: David J. Brezner Dorsey & Whitney LLP

20070105180 - Methods for detecting sleepiness: The invention generally provides a biomarker for sleepiness, a method for detecting sleepiness, and a method of identifying nucleic acids associated with sleepiness.... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20070105182 - Cell-permeable green fluorescent protein: This invention relates to methods and compositions for designing novel fluorescent proteins, preferably to a green fluorescent proteins (GFP). The engineered GFPs are modified by substituting negatively charged amino acids with positively charged amino acids on the exterior of the protein making the protein cell permeable. The ability of the... Agent: Quarles & Brady LLP

20070105181 - Identification of cancer biomarkers and phosphorylated pdroteins: Methods are provided for identifying proteins that are differentially expressed in disease state and normal cells. Stable isotope labeling of cells in culture allows for the identification of a multiplicity of proteins whose differential abundance in normal and disease state cells can be indicative of the disease state. Biomarkers are... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070105184 - Biosensor method and system based on feature vector extraction: A method of biosensor-based detection of toxins comprises the steps of providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a time-dependent biosensor signal from the biosensor in the gas or liquid medium to be monitored or analyzed for the... Agent: Akerman Senterfitt

20070105183 - Probe for measuring electric potential of cell: A probe for measuring an electric potential of a cell includes a plate having a surface having a first cavity provided therein, and a sensor element provided in the first cavity. A second cavity is provided in the bottom surface of the first cavity. The first flow passage having first... Agent: Wenderoth, Lind & Ponack L.L.P.

20070105185 - Raised surface assay plate: The assay plate includes a substrate having an substrate surface and at least one raised pad extending from the substrate surface. The raised pad includes a substantially planar sample receiving surface configured for holding a sample thereon for in situ experimentation. The sample receiving surface preferably has at least one... Agent: Philip S. Johnson Johnson & Johnson

20070105186 - Method for preserving microbial cells: A method of preserving microbial cells is provided, comprising dispensing microbial cells into preservation medium to produce a microbial cell suspension, impregnating a swab with a predetermined amount of the microbial cell suspension, and desiccating the impregnated swab. In one embodiment, the swab comprises a first end and a second... Agent: Warner J Delaune Jr Adams And Reese LLP

20070105188 - Method of determining sperm capacitation: This invention describes unique patterns of distribution of ganglioside GM1 in non-capacitated sperm and demonstrates that the pattern of distribution of GM1 undergoes changes that can be correlated with the process of capacitation and/or with acrosomal exocytosis. Accordingly, the present invention discloses a method for determining the ability of sperm... Agent: Hodgson Russ LLP

20070105187 - Methods and materials for fixing cytological samples: A method of fixing a biological sample on a slide for cytological analysis, includes transferring a sample to a slide, applying a material having a slide-fixing amount of an inactivated, fixative to the slide, and activating the fixative. By way of example, the material may comprise a tape impregnated with... Agent: VistaIPLaw Group LLP

20070105189 - Process for producing carotenoid compound: The present invention relates to a process for producing zeaxanthin, β-carotene, or lycopene, comprising inducing mutation in a carotenoid-producing microorganism in which the base sequence of DNA corresponding to 16S ribosomal RNA is substantially homologous to the base sequence described in SEQ ID NO: 1; screening for a mutant strain... Agent: Novak Druce Deluca & Quigg, LLP

20070105190 - Processes for making protein hydrolysates from animal peptone and for preserving mucosa: A process for hydrolyzing products with enzymatic activity remaining in peptone solutions after mucosa hydrolysis is provided along with a process for preserving mucosa tissue. Broadly, the processes are carried out by hydrolyzing mucosa tissue according to conventional heparin manufacturing processes wherein an excess quantity of proteolytic enzymes is used.... Agent: Westman Champlin & Kelly, P.A.

20070105192 - Cyclodextrin affinity purification: A method of immobilizing a molecular species that include a starch-binding domain is provided. There also is provided a material upon which the molecular species is immobilized, and a material that is capable of immobilizing the species The method includes binding the species to a solid support, e.g., membranes, chromatographic... Agent: Morgan, Lewis & Bockius LLP (sf)

20070105195 - Entropic bristle domain sequences and their use in recombinant protein production: Compositions and methods for recombinant protein production and, more particularly, fusion polypeptides, polynucleotides encoding fusion polypeptides, expression vectors, kits, and related methods for recombinant protein production, are provided.... Agent: Seed Intellectual Property Law Group PLLC

20070105194 - Method for producing yeast expressed hpv types 6 and 16 capsid proteins: Mosaic VLPs of viral capsid proteins from different virus types are described, as are methods of making the same. Specifically, a diploid yeast strain that coexpresses the L1 and L2 capsid proteins of both HPV-6 and HPV-16 as mosaic VLPs is described. The mosaic VLPs induced the production of conformational... Agent: Novartis Vaccines And Diagnostics Inc.

20070105196 - Modified green fluorescent proteins and methods for using same: The present invention provides nucleic acid molecules encoding mutant fluorescent proteins as well as proteins encoded by these nucleic acids. In addition, host-cells, stable cell lines and transgenic organisms comprising the above-referenced nucleic acid molecules are provided. The subject protein and nucleic acid compositions find use in a variety of... Agent: Patterson & Sheridan, L.L.P.

20070105198 - Nf-kappa b activating gene: Provided are proteins having NF-κB activity, which are used for diagnosing, treating or preventing diseases associated with the excessive activation or inhibition of NF-κB. Using plasmid pNFκB-Luc, cDNA encoding a protein capable of activating NF-κB has been cloned from a cDNA library constructed from human lung fibroblasts, and the DNA... Agent: Birch Stewart Kolasch & Birch

20070105197 - Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from comamonas testosteroni 5-mgam-4d and recombinant organisms expressing those enzymes useful for the production of amides and acids: The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitrites to the corresponding amides, and the amidase is useful for hydrolysis of amides to... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070105191 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Heller Ehrman LLP

20070105193 - Severe acute respiratory syndrome dna vaccine compositions and methods of use: The present invention is directed to raising a detectable immune response in a vertebrate by administering in vivo, into a tissue of the vertebrate, at least one polynucleotide comprising one or more regions of nucleic acid encoding a SARS-CoV protein or a fragment, a variant, or a derivative thereof. The... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070105199 - Methods for generating monovalent igg: The present invention relates to monovalent antibody, methods of making thereof and therapeutic uses thereof. In particular, the present invention provides a heterodimeric polypeptide comprising an immunoglobulin heavy chain and a fusion protein comprising an immunoglobulin light chain and an Fc molecule.... Agent: Amgen Inc.

20070105200 - Enzymatic process for obtaining increased yield of lactobionic acid: A process for obtaining increased yields and/or a reduced reaction time in enzymatic conversion of lactose to lactobionic acid comprising adding to a dairy substrate, such as milk, whey or lac-tose solution, a carbohydrate oxidase, capable of converting lactose to lactobionic acid, wherein the process is performed under stable control... Agent: Foley And Lardner LLP Suite 500

20070105201 - Process for the enantiomeric resolution of 1-substituted 2-(aminomethyl)-pyrrolidines by amidation in the presence of lipases: p

20070105202 - Dna encoding a protein having d-lactate dehydrogenase activity and uses thereof: This invention provides a polynucleotide that encodes a protein having lactate dehydrogenase activity and such protein that can be used for producing D-lactic acid. This polynucleotide has the nucleotide sequence as shown in SEQ ID NO: 1 (a), and it hybridizes under stringent conditions with a probe comprising all or... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070105203 - Enterobacteriaceae fermentation strains: Methods are provided for preparing improved fermentation strains of the family Enterobacteriaceae which comprise the steps of eliminating the cryptic plasmid from the progenitor strain thereby creating the improved strain. Methods for reducing the mobilization properties of resident plasmids in an Enterobacteriaceae strain containing a cryptic plasmid are also provided.... Agent: Genencor International, Inc.

20070105204 - Methods for producing propylene glycol monoesters using a lipase: The present invention relates to methods for producing propylene glycol monoesters (PGMEs). A method comprises contacting a fatty acid material with a lipase to form a first composition, contacting the first composition with propylene glycol to form a second composition, and heating the second composition, wherein a PGME composition is... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070105205 - Method and apparatus for processing organic material: A method and an apparatus for processing organic material, the method employing at least two reactors and including the steps of combining carbon dioxide or carbon-dioxide containing gas and ammonia or ammonia-containing material in a first reactor to form a buffer compound/buffer compounds, then feeding the buffer compound or buffer... Agent: Sughrue Mion, PLLC

20070105206 - Fluidic device: A fluidic device for cell electroporation, cell lysis, and cell electrofusion based on constant DC voltage and geometric variation is provided. The fluidic device can be used with prokaryotic or eukaryotic cells. In addition, the device can be used for electroporative delivery of compounds, drugs, and genes into prokaryotic and... Agent: Brinks Hofer Gilson & Lione

20070105207 - Aggrecanase structure: This invention relates to aggrecanase polypeptides and aggrecanase polypeptide/ligand complexes, crystals of aggrecanase and aggrecanase polypeptide/ligand complexes, and related methods and software systems.... Agent: Fish & Richardson P.C.

20070105208 - Minus strand rna virus vector carrying gene modified in high mutation region: The present invention provides minus-strand RNA viruses carrying a foreign gene that has a partial sequence corresponding to part of the minus-strand RNA virus E sequence and where the partial sequence has been altered. A foreign gene comprising such a partial E sequence is found to undergo mutations at high... Agent: Clark & Elbing LLP

20070105209 - Feed additives for reducing odor of animal waste products: The invention relates to biological compositions comprising yeast cells that can be added to animal feed which upon ingestion by an animal can reduce the odor of manure produced by the animal. The invention also relates to methods for manufacturing the biological compositions, and methods of using the biological compositions... Agent: Jones Day

20070105211 - Optical fiber array device capable of simultaneously performing multiple functional assays: Disclosed is an assay device, having at least one optical fiber array with wells etched in one end of each of the fibers, and several microbeads adapted to be coated with cells of the same cellular type, wherein the microbeads are designed to be accommodated, one in each well, and... Agent: Eric P. Mirabez

20070105210 - Work device comprising bordered work zones, on-chip laboratory and microsystem: The present invention relates to a work device (1) comprising work zones. It can be used to obtain a matrix of drops on a surface, using a liquid of interest (E). It comprises a work box (Bo) provided with means (o, s) for introducing and extracting the liquid respectively into... Agent: Mckenna Long & Aldridge LLP

20070105212 - Temperature control for light-emitting diode stabilization: A method for stabilizing the temperature of an LED is provided. A method is provided that includes providing a system comprising an LED, a reaction region, and a sample in the reaction region; generating excitation beams with the LED; directing excitation beams to the sample; detecting an optical property of... Agent: Kilyk & Bowersox, P.l.l.c.

20070105213 - Fluid manipulation assembly: Microfluidic assemblies, systems, and methods are provided for manipulating fluid samples. Assemblies include an elastically deformable cover layer and a less elastically deformable substrate. The methods include deforming the substrate through the cover layer so that when the cover layer rebounds a new communication results in the assembly between the... Agent: Kilyk & Bowersox, P.l.l.c.

20070105214 - Automated cellular assaying systems and related components and methods: High throughput and automated cellular disruption systems that substantially uniformly disrupt cells as part of cellular motility assays as wells as other assay types are provided. In addition, various system components, including holding blocks, holding block loading devices, and system software, are also provided. Moreover, related methods that utilize these... Agent: Quine Intellectual Property Law Group, P.C.

20070105216 - Method for the controlled release of calcium from intracellular calcium stores of oocytes: A method for the controlled release of calcium from intracellular calcium stores of oocytes, by i) establishing an optimum profile for release of calcium from intracellular calcium stores of oocytes, and ii) applying the following cycles to the oocytes: (A) a pulse perfusion cycle which comprises a step of perfusing... Agent: Foley And Lardner LLP Suite 500

20070105215 - Method of culturing stem cells using abc transporters: Disclosed herein is a method of culturing stem cells, which can remove differentiated cells generated in stem cell culture, using ABC transporters, according to a stem cell's characteristic in that the stem cells contain a plurality of the ABC transporters. The method comprises the steps of: bringing a stem cell... Agent: Cantor Colburn, LLP

20070105217 - Compositions and methods of vascular injury repair: The present invention relates to pharmaceutical compositions comprising a chemotactic hematopoietic stem cell product comprising an enriched population of CD34+ cells containing a subpopulation of cells having chemotactic activity, methods of preparing these compositions and use of these compositions to treat or repair vascular injury, including infarcted myocardium.... Agent: Patent Docket Administrator Lowenstein Sandler P.C.

20070105218 - Lupus antibodies for passive immunotherapy of hiv/aids: Disclosed are monoclonal antibodies and antibody fragments which recognize antigens encoded by HERV DNA sequences, and methods for production, including recombinant antibody fragments derived from lymphoid cells of lupus patients that make antibodies which neutralize HIV.... Agent: NeifeldIPLaw, PC

20070105219 - Retrovirus from the hiv group and its use: A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070105220 - Erythrocytic cells and method for loading solutes: A dehydrated composition is provided that includes freeze-dried erythrocytic cells. The invention further provides methods for loading a solute into a cell comprising disposing a cell in a solution having a solute concentration of sufficient magnitude to produce hyperosmotic pressure on the cell for transferring a solute from the solution... Agent: Townsend And Townsend And Crew, LLP

20070105221 - Method of isolating and culturing mesenchymal stem cell derived from cryopreserved umbilical cord blood: The present invention relates to a method of isolating and culturing mesenchymal stem cells using cryopreserved umbilical cord blood that is most ideal for cell therapy. The method comprises thawing cryopreserved umbilical cord blood and adding αMEM (alpha-minimum essential medium) thereto, followed by centrifugation to harvest monocytes; isolating CD133 positive... Agent: Venable LLP

20070105222 - In vitro growth of tissues suitable to the formation of bone and bone forming tissue formed thereby: The present invention is directed to a device for the growth of new bone or bone-like tissue under in vitro cell culture conditions.... Agent: Baker & Mckenzie LLP

20070105223 - Non uniform electric field chamber for cell fusion: An apparatus is provided for carrying out fusion of biological cells (10) and includes a base member (24) on which a conductive outer electrode (18) is supported and has an outer electrode radius (r2) and has an electrode height (19). A conductive inner electrode (20) is supported on the base... Agent: Marvin S Towsend Patent Attorney

20070105224 - Genetic modification of liver cells to enhance metabolic and physiological efficacy: Retroviral vectors containing hepatic nuclear factor 1 or hepatic nuclear factor 4α, and cells comprising the same are provided.... Agent: Birch Stewart Kolasch & Birch

20070105225 - Dna and proteins or peptides specific of bacteria of the neisseria meningitidis species, methods for obtaining them and biological applications thereof: The DNA of the invention are characterised in that they concern the whole or part of genes, with their reading frame, to be found in Neisseria meningitidis but not in Neisseria gonorrhoeae, or in Neisseria lactamica except the genes involved in the biosynthesis of the polysaccharide capsule, frp A, frp... Agent: Nixon & Vanderhye, PC

20070099170 - Method for treatment and storage of blood and blood products using endogenous alloxazines and acetate: Methods are provided for treatment and storage of blood and blood products using at least endogenous alloxazines and acetate. Methods include adding a blood component additive solution comprising at least an endogenous alloxazine and acetate to a fluid comprising at least one collected blood component.... Agent: Gambro, Inc Patent Department

20070099172 - Methods and device for freezing and thawing biological samples: A method for changing the temperature of a sample from an initial temperature via an intermediate temperature to a final temperature, one of the initial and final temperatures being above the freezing point of the sample and the other being below the freezing point is provided. The method is for... Agent: Gary M. Nath

20070099171 - Sperm suspensions for sorting into x or y chromosome-bearing enriched populations: The present invention provides a method of cryopreserving sperm that have been selected for a specific characteristic. In a preferred embodiment, the method is employed to freeze sex-selected sperm. Although the cryopreservation method of the invention can be used to freeze sperm selected by any number of selection methods, selection... Agent: Santangelo Law Offices, P.C.

20070099173 - Electronic device for communication with living cells: The present invention provides a surface-substrate for adherence of cells thereto. The surface-substrate comprises at least one micronail structure protruding from the surface, at least a region of the micronail having cellular-internalization promoting properties. The invention also provides an electronic device comprising a transistor structure, in which a gate electrode... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070099176 - Methods of expressing lim mineralization protein: Methods of expressing LIM mineralization protein in mammalian cells are described. Methods of expressing LIM mineralization protein and assessing glycosylation of the LIM mineralization protein in prokaryotic and non-mammalian eukaryotic cells are also described. The methods involve transfecting the cells with an isolated nucleic acid comprising a nucleotide sequence encoding... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20070099175 - Modified fluorescent proteins: Functional red fluorescent proteins, nucleic acids encoding them, and methods for their use.... Agent: Fina Technology Inc

20070099174 - Rapid testing for nutrients: This invention presents the rapid testing for nutrients in products including, but not limited, medicines, food supplements or additives, cosmetics, drinks, fruits, vegetables, and etc. The rapid testing is performed on strips coated with indicators. Nutrients such as Vitamin C can be detected in very small volume. The detection is... Agent: Xiaoliang Han

20070099177 - Agents and methods for detecting human adenoviruses: The invention relates to labeled or unlabelled nucleic acids to specifically bind to DNA of human adenoviruses (HAdV DNA), whereby the nucleic acid a) possesses the sequence SEQ ID NO. 1, SEQ ID NO. 2, or SEQ ID NO. 3, b) possesses a sequence with a homology of greater than... Agent: Akerman Senterfitt

20070099182 - Comparative ligand mapping from mhc class i positive cells: The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the present invention relates to the isolation, purification and identification of these peptide ligands from soluble class I and class 11 MHC molecules... Agent: Dunlap, Codding & Rogers P.C.

20070099183 - Comparative ligand mapping from mhc positive cells: The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the present invention relates to the isolation, purification and identification of these peptide ligands from soluble class I and class II MHC molecules... Agent: Dunlap, Codding & Rogers P.C.

20070099180 - Evanescent wave sensor with attached ligand: The invention in particular embodiments provides an evanescent wave sensor which includes a ligand bound to a sensor substrate via a β-hydroxy-linker moiety, as defined herein. Methods of making the subject evanescent wave sensors are also provided which include contacting a first reactive moiety which has an epoxy-ring moiety with... Agent: Agilent Technologies Inc.

20070099178 - Method for detecting sars coronavirus: This invention provides: a method for detecting SARS pathogenic viruses with high sensitivity and rapidity for diagnosing severe acute respiratory syndrome (SARS); an oligonucleotide primer that can specifically hybridize with any nucleotide sequence constructed based on the nucleotide sequence of RNA polymerase of the SARS coronavirus; a method for nucleic... Agent: Sughrue Mion, PLLC

20070099179 - Method for inducing hepatitis c virus (hcv) replication in vitro, cells and cell lines enabling robust hcv replication and kit therefor: The present invention relates to hepatitis C virus (HCV). More particularly, the invention relates to the development of a tool suitable for the search, discovery and validation of novel HCV antiviral drugs and therapies (e.g. vaccine). The invention further relates to methods for inducing HCV replication in vitro, and more... Agent: Goudreau Gage Dubuc

20070099181 - Postweaning multisystemic wasting syndrome virus from pigs: The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in... Agent: Frommer Lawrence & Haug

20070099203 - Biomarkers for neurodegenerative disorders: The present invention provides methods for diagnosing neurodegenerative disease, such as Alzheimer's Disease, Parkinson's Disease, and dementia with Lewy body disease by detecting a pattern of gene product expression in a cerebrospinal fluid sample and comparing the pattern of gene product expression from the sample to a library of gene... Agent: Bozicevic, Field & Francis LLP

20070099209 - Compositions and methods for treating and diagnosing cancer: The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles associated with solid tumor stem cells, as well as novel stem cell cancer gene signatures useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem... Agent: Medlen & Carroll, LLP

20070099205 - Compositions for detection of a target nucleic acid sequence: The invention relates to compositions for generating a signal indicative of the presence of a target nucleic acid in a sample. The compositions include a reverse transcriptase, a nuclease, an upstream primer and downstream probe.... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070099206 - Compositions for detection of a target nucleic acid sequence: The invention relates to compositions for generating a signal indicative of the presence of a target nucleic acid in a sample, where the compositions include an RNA polymerase, a FEN nuclease, and a probe.... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070099228 - Concatameric ligation products: compositions, methods and kits for same: The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample, and methods compositions and kits for forming concatameric ligation products. In some embodiments of the present teachings, oligonucleotides are hybridized to complementary target polynucleotides and are ligated together to form... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070099212 - Consecutive base single molecule sequencing: The invention provides methods for sequencing polynucleotide molecules using single molecule sequencing techniques, where a plurality of labeled nucleotides are incorporated consecutively into an individual primer molecule.... Agent: Goodwin Procter LLP Patent Administrator

20070099213 - Corynebacterium glutamicum genes encoding novel proteins: Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield

20070099192 - Denaturing size-fractionation in analysis of small rna: The invention relates to analyzing a sample containing polynucleotides having small RNA binding sites. In exemplary embodiments, the sample is contacted with a size-fractionation medium under denaturing conditions to provide a fraction containing small RNA. The fraction containing small RNA is then contacted with an array under conditions sufficient to... Agent: Agilent Technologies Inc.

20070099211 - Detection of nucleic acid amplification: Methods for detecting a target polynucleotide sequences are provided that utilize a probe having a target-complementary segment and a detectable tag. By cleaving the detectable tab and associating the tag with a tag complement coupled to an electrode, an electrochemical signal can be detected that is related to the presence... Agent: Kolisch Hartwell, P.C.

20070099207 - Devices and methods for enrichment and alteration of circulating tumor cells and other particles: The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.... Agent: Clark & Elbing LLP

20070099200 - High throughput mobility shift: The present invention provides novel microfluidic devices and methods for performing pulsed field mobility shift assays in microfluidic devices. In particular the devices and methods of the invention utilize differences between electrophoretic mobilities (e.g., as between reactants and products, especially in non-fluorogenic reactions) in order to separate the species and... Agent: Caliper Life Sciences, Inc.

20070099204 - Identification and quantification of a plurality of biological (micro)organisms or their components: Disclosed is a system and method conducting real-time PCR. Capture molecules of a specific design are immobilized on a solid support, and contacted with amplicons produced in one or more PCR cycles. Detection of amplicons may take place during or between the PCR cycles while the solid support is in... Agent: Howrey LLP

20070099214 - Identification of a pin specific gene and protein (pin-1) useful as a diagnostic treatment for prostate cancer: The invention relates to nucleic acids encoding a mammalian ABCA5 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, PIN. Further, the invention relates to diagnostic assays for identifying the DNA-binding protein ABCA5 (also known as PIN-1). The invention... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070099218 - Light transmitted assay beads: A micro bead having a digitally coded structure that is partially transmissive and opaque to light. The pattern of transmitted light is determined by to decode the bead. The coded bead may be structured a series of alternating light transmissive and opaque sections, with relative positions, widths and spacing resembling... Agent: Liu & Liu

20070099229 - Marburg i mutant of factor vii activating protease (fsap) as risk factor for arterial thrombosis and methods of detecting fsap and fsap mutations: A novel arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII-activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070099189 - Method and apparatus for detecting substances or analytes from the analysis of one or more samples: The invention relates to a method and apparatus for detecting substances or analytes form the analysis of one or several samples. The method comprises mixing the sample with a suitable liquid buffer, homogenizing said sample, adding reagents thereto, filtering it, injecting the sample into the incubation chamber, allowing the sample... Agent: Merchant & Gould PC

20070099198 - Method and apparatus for detection, identification and quantification of single-and multi-analytes in affinity-based sensor arrays: The disclosure provides methods, device, and systems for analyzing biological array data. In particular, the disclosure provide methods and computer implemented techniques for reducing interference in microarray data, and exploiting it to obtain more accurate readouts... Agent: Buchanan, Ingersoll & Rooney LLP

20070099190 - Method for distinguishing leukemia subtypes: Disclosed is a method for distinguishing leukemia subtypes t(15;17), t(8;21), inv(16), inv(3), complex aberrant karyotype (CA), AML-MLL, normal karyotype (NK), AML-other (trisomy 8, trisomy 11, trisomy 13, monosomy 7, del(5q), del(9q), t(6;9); del(20q) and del(12p) and trisomy 4), ALL-MLL, ALL-Ph+, ALL-t(8;14), T-ALL, other B-lineage (OBL), CML, normal-BM, and/or CLL in... Agent: Roche Molecular Systems Inc Patent Law Department

20070099217 - Method for stress evaluation: The molecular reaction mechanism that associates the clock gene with stress is elucidated based on the finding that stress is accompanied by an increase in the expression level of Per1 gene in peripheral tissues, stress response does not change the circadian rhythm in peripheral tissues, and Per1 gene increases in... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070099221 - Method of analyzing nucleic acid: An object of the invention is to avoid any possibility of error caused by a nucleic acid used as a standard, a probe, or probe spot, etc. or enable correction thereof, to analyze the frequency of gene expressions with high reproducibility, and to analyze any change of primary structure in... Agent: Scully Scott Murphy & Presser, PC

20070099202 - Methods and compositions for assessment of pulmonary function and disorders: The present invention provides methods for the assessment of risk of developing lung cancer in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing lung cancer. Nucleotide probes and primers, kits, and microarrays... Agent: Knobbe Martens Olson & Bear LLP

20070099222 - Methods and compositions for labeling nucleic acids: The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. Certain methods are provided that include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label. Other methods are provided that include... Agent: Choate, Hall & Stewart LLP

20070099195 - Methods and compositions for separating nucleic acids from a solid support: Methods and compositions for separating nucleic acids from a solid support are provided. In the subject methods, a silica containing solid support having nucleic acids immobilized on a surface thereof is subjected to cleavage conditions, such that a fluid cleavage product that includes nucleic acids and silica is produced. The... Agent: Agilent Technologies Inc.

20070099199 - Methods and compositions for treating cervical cancer: The invention provides methods and compositions for treating pathogen infections, particularly human papillomavirus infections. Specifically, the invention provides a method of screening that involves determining an effect of a candidate agent on binding of an E6 protein from an oncogenic strain of HPV to a polypeptide containing the amino acid... Agent: Townsend And Townsend And Crew, LLP

20070099186 - Methods and means for the treatment of disorders associated with cellular senescence: This invention relates to mechanisms of cellular senescence and, in particular, to the role of DNA repair and DNA damage checkpoint pathways in the induction and maintenance of the senescent state. Methods and means of inducing cell cycle progression in senescent cells by inhibiting DNA damage checkpoint pathways are provided... Agent: Bozicevic, Field & Francis LLP

20070099191 - Methods and systems for evaluating the length of elongated elements: Systems and methods are disclosed for evaluating the length of elongated elements in a sample. The disclosed systems and methods may include using a direct current stimulus to determine a direct current base length region corresponding to at least a portion of the sample. Furthermore, the disclosed systems and methods... Agent: Merchant & Gould PC

20070099201 - Methods for detecting and quantifying binding and inhibition of binding of species to nucleic acids: The invention features methods for detecting and quantifying the binding or inhibition of binding of species to biopolymers, e.g., nucleic acids. The invention is based on the use of probes that have magnetic relaxation properties that are affected by the presence of paramagnetic metal ions, e.g., Mn2+. Any class of... Agent: Clark & Elbing LLP

20070099185 - Methods for the identification of agents that modulate the structure and processing of beta-amyloid precursor protein: The present invention provides methods for the screening and identification of agents from a large library of molecular structures that can alter the cleavage of amyloid precursor protein (AP). Agents identified by the methods of the present invention that modify the cleavage of APP can be used in the treatment... Agent: Townsend And Townsend And Crew, LLP

20070099210 - Methods of labelling polynucleotides with dibenzorhodamine dyes: including nitrogen- and aryl-substituted forms thereof, wherein substituents at positions C14 to C18 taken separately are selected from the group consisting of hydrogen, chlorine, fluorine, lower alkyl, carboxylic acid, sulfonic acid, —CH2OH, alkoxy, phenoxy, linking group, and substituted forms thereof. The invention further includes energy transfer dyes comprising the dibenzorhodamine... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070099197 - Methods of prognosis of prostate cancer: The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis... Agent: Fenwick & West LLP

20070099226 - Modified cyclic nucleotide gated ion channels: The present invention provides modified cyclic nucleotide gated (CNG) channels. In particularly preferred embodiments, the modified CNG channels exhibit increased sensitivity and specificity for cAMP, as compared to wild-type CNG channels. In additional embodiments, regulation by Ca2+-calmodulin has been removed in the modified CNG channels. Convenient optical methods for detecting... Agent: Medlen & Carroll, LLP Suite 350

20070099216 - Mutant endonuclease: A novel mutant endonuclease V not exhibiting a nonspecific nucleic acid cleavage activity but showing a specific activity. The present invention relates to a mutant endonuclease V not exhibiting a nonspecific nucleic acid cleavage activity but having a specific activity, to a gene coding for the endonuclease V, to a... Agent: Sughrue-265550

20070099215 - Novel bak binding protein, dna encoding the protein, and methods of use thereof: The present invention provides polynucleotide sequences (bbp) encoding a Bak Binding Protein (BBP) and fragments thereof that bind to Bak. The invention also provides a BBP which binds to Bak. The invention also provides recombinant host cells containing polynucleotides encoding BBP. The invention further provides antibodies that specifically bind to... Agent: Sheridan Ross PC

20070099188 - Novel method for finding mutations caused by the insertion of repeated dnas: The present invention provides a method of for identifying repeat insertion mutation, a method for identifying or classifying genetic diseases characterized by genome rearrangement, as well as a method for mapping complex traits controlled by repeat insertion mutations in a plant or mammalian subject.... Agent: Edwards Angell Palmer & Dodge LLP

20070099230 - Novel nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecles, atpase molecules, acyltransferase molecules, pyridoxal-phosphate dependant enzyme molecules and uses therefor: The invention provides isolated nucleic acids molecules that encode novel polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a sequence of the... Agent: Millennium Pharmaceuticals, Inc.

20070099196 - Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mrnas: The invention relates relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNAs and their target mRNAs, as well as small interfering RNAs (siRNAs).... Agent: Clark & Elbing LLP

20070099184 - Nucleic acid amplication utilizing intermediate duplexes: This invention provides for a novel amplification procedure for nucleic acid. The method uses a wild type or mutant RNA polymerase designed to transcribe both deoxyribonucleotides and ribonucleotides (see FIGS. 1-7).... Agent: Beth L Kelly Townsend And Townsend And Crew

20070099187 - Nucleic acid array: A nucleic acid array is provided that can efficiently perform analysis, and further, can estimate the number of expressions of amino acid mutations for all cases by use of a smaller number of arrays. The nucleic acid array has a plurality of oligonucleotides immobilized on a substrate, wherein the oligonucleotide... Agent: Fitzpatrick Cella Harper & Scinto

20070099220 - Organic salt additives for nucleic acid amplification: The present invention is directed to the use of a benzimidazolium compound comprising a side chain at at least one of its N-residues, said chain being either a Cn-alkyl or a substituted Cn-alkyl, characterized in that preferably n is ≧3, as an additive for a nucleic acid amplification reaction.... Agent: Roche Diagnostics Operations Inc.

20070099193 - Probe/target stabilization with add-in oligo: The invention relates to analyzing a sample containing small RNAs. In exemplary embodiments, the sample is contacted with an array in the presence of an add-in oligo. In typical embodiments, probes on the array include regions that are complementary to small RNAs and regions that are complementary to the add-in... Agent: Agilent Technologies Inc.

20070099194 - Quality control of probe attachment on electrodes: The present disclosure relates to methods of quantifying nucleic acid molecules immobilized on an electrode of an electrochemical assay chip. Such quantification can be used in testing and quality control of assay chips. Materials and instrumentation useful in performing such techniques are also disclosed.... Agent: Knobbe Martens Olson & Bear LLP

20070099225 - Separation of chromosomes using an affinity-based magnetic bead separation in suspension: A method for separating and isolating a target chromosome from a cellular sample by using a DNA probe with a fluorescein tag. Magnetic beads bound to anti-fluorescein isothiocyanate antibody were reacted with the fluorescently labeled pool of chromosomes and then separated in suspension by exposure to a magnetic field.... Agent: Stinson Morrison Hecker LLP Attn: Patent Group

20070099227 - Significance analysis using data smoothing with shaped response functions: Methods, systems and computer readable media for analyzing data. A variable width window is applied to data points from the data which are ordered to correspond to locations along a chromosome of targeted nucleotide sequences whose relative abundances are represented by the data points. The window applied is a moving... Agent: Agilent Technologies Inc.

20070099208 - Single molecule arrays for genetic and chemical analysis: Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the invention comprise concatemers of DNA fragments that are randomly disposed on a regular array of discrete spaced apart regions,... Agent: Stephen C. Macevicz C/o Chief Financial Officer

20070099223 - Single nucleotide polymorphism associated with stroke susceptibility: The present invention identifies various risk alleles, particularly a risk allele of SNP rs918592, within the PDE4D gene as novel stroke associated risk markers. These markers may be used for identifying a subject's susceptibility to stroke and diagnosing a subject's susceptibility to a particular type of stroke based on the... Agent: Whiteford, Taylor & Preston, LLP Attn: Gregory M Stone

20070099224 - Slc1a1 marker for anxiety disorder: The present invention provides methods for diagnosing or identifying susceptibility of a subject to an anxiety or mood disorder. One method involves testing a sample obtained from the subject for the presence of a polymorphism in Intron 10 of the SLC1A1 gene. The presence of allele G or allele A... Agent: Winston & Strawn LLP Patent Department

20070099219 - Systems and methods for treating, diagnosing and predicting the occurence of a medical condition: Methods and systems are provided that use clinical information, molecular information and computer-generated morphometric information in a predictive model for predicting the occurrence (e.g., recurrence) of a medical condition, for example, cancer. In an embodiment, a model that predicts prostate cancer recurrence is provided, where the model is based on... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20070099231 - Bioelastomer: A bioelastomer comprising a proresilin fragment capable of forming of beta-turns and able to cross link through dityrosine formation.... Agent: Sughrue Mion, PLLC

20070099233 - Cross-reference: The invention provides sensors that are useful for detecting and measuring chemical characteristics and physical properties of compositions containing analytes. The invention further provides, among other things, methods for making the sensors and for using them, as well as modified cells having sensors of the invention therein.... Agent: Patent Docket Administrator Lowenstein Sandler PC

20070099232 - Ecdysone receptor ligand-binding domain structure: The present invention relates to structural studies of the functional insect ecdysone receptor. More particularly, the invention relates to the crystal structure of the whitefly ecdysone receptor ligand-binding domain, specifically that of Bemisia tabaci, and uses of the crystal and related structural information to select and screen for compounds that... Agent: Greenlee Winner And Sullivan P C

20070099238 - Enhancement of emission using metal coated dielectric nanoparticles: Fluorescent dyes or quantum dots may be embedded in a dielectric volume of appropriate dimensions where typically half the surface of the dielectric volume is covered by a metal coating allow for increased absorption and emission efficiencies. Alternatively, fluorescent dyes or quantum dots may be attached to metal coated dielectric... Agent: Agilent Technologies Inc.

20070099235 - Method for designing surfaces: A method of producing a binding surface for a target molecule having a functional binding site, which method comprises: (i) identifying within the target molecule an anchor site which is remote from the functional binding site; (ii) generating a pharmacophore model for the anchor site; (iii) using the pharmacophore model... Agent: Howrey LLP

20070099241 - Method of detecting a subfraction of probnp: The present invention relates to antibodies specifically binding to native proBNP, a method for specific detection of native proBNP, a method of correlating the level of native proBNP to the diagnosis of heart failure, a kit for detection of native proBNP and to a hybridoma cell line producing an antibody... Agent: Roche Diagnostics Operations Inc.

20070099239 - Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease: The present invention identifies circulating proteins that are differentially expressed in atherosclerosis. Circulating levels of these proteins, particularly as a panel of proteins, can discriminate patients with acute myocardial infarction from those with stable exertional angina and from those with no history of atherosclerotic cardiovascular disease. Such levels can also... Agent: Bozicevic, Field & Francis LLP

20070099240 - Pixel arrays: The invention relates to the detection of biomolecules or analogs of the biomolecules in micro-arrays and the supports used for the micro-arrays. Methods for determining or testing binding of a first member molecule within an array or library of tentative first member binding molecules for binding with a second member... Agent: Trask Britt

20070099237 - Reaction co-crystallization of molecular complexes or co-crystals: Multi-component crystals (co-crystals) are prepared by combining co-crystal components in non-stoichiometric concentrations in solution. The solubility of the molecular complex in the solvent is reduced, increasing the probability that the molecular complex is the least soluble form in the system, upon which it precipitates. A crystalline product is produced without... Agent: Harness, Dickey & Pierce, P.L.C

20070099234 - Specific detection of chitin using chitin-binding domain: Methods and kits are provided for detecting chitin in biological samples using chitin-binding domain (CBD).... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20070099236 - Test yield estimate for semiconductor products created from a library: Disclosed is a method that predicts test yield for a semiconductor product, prior to design layout. This is accomplished by applying a critical area analysis to individual library elements that are used to form a specific product and by estimating the test yield impact of combining these library elements. For... Agent: Frederick W. Gibb, Iii Gibb Intellectual Property Law Firm, LLC

20070099246 - Antibodies, assays and kits to quantitate cartilage destruction: Antibody compositions specific for peptides released during arthritic cartilage destruction are provided as reagents for assay of progression of arthritic processes for antibodies, and as diagnostic and prognostic agents. Also provided are methods and kits for this assay.... Agent: Lawson & Weitzen, LLP

20070099245 - Assays for neutralizing antibodies: This invention relates to assays for the detection of neutralizing antibodies. Further, this invention relates to assays for the detection of neutralizing antibodies specific for bone morphogenetic protein 2 (BMP-2) or capable of inhibiting at least one of the biological activities of BMP-2.... Agent: Wyeth/finnegan Henderson, LLP

20070099242 - Lipoprotein-associated markers for cardiovascular disease: The invention provides methods of screening a mammalian subject to determine if the subject is at risk to develop, or is suffering from, cardiovascular disease. The methods comprise detecting an amount of at least one biomarker in a biological sample, or HDL subfraction thereof, from the subject, and comparing the... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20070099243 - Method for searching myelin using gonadotropin-releasing hormone receptors as a new biomarker: The present invention relates to a method for searching myelin using gonadotropin-releasing hormone receptors (GnRH-R) as a biomarker, more precisely, a method for investigating the distribution of myelin by immunohistochemical staining using GnRH-R antibody, based on the fact that GnRH-R and myelin are observed in the same region. The method... Agent: Jhk Law

20070099247 - Polypeptide display libraries and methods of making and using thereof: Disclosed herein are expression vectors which display a passenger polypeptide on the outer surface of a biological entity. As disclosed herein the displayed passenger polypeptide is capable of interacting or binding with a given ligand. Also disclosed are methods of making and using the expression vectors. N/C terminal fusion expression... Agent: Smith, Gambrell & Russell, LLP (uc) Suzannah K. Sundby

20070099244 - Specific binding sites in collagen for integrins and use thereof: The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising this novel sequence and the use of the peptides in enabling cell adhesion. Also provided herein are methods... Agent: Benjamin Aaron Adler Adler & Associates

20070099252 - Diagnostic application of mail: The present invention provides nucleic acids. Polypeptides, antibodies and cells related to MAIL (Molecule possessing Ankyrin repeats Induced by LPS; or IκB-ζ), a novel member of the IκB family, expressed in LPS stimulated monocytes and uses thereof. The isolated nucleic acids, polypeptides, antibodies and cells of the invention can be... Agent: Philip S. Johnson Johnson & Johnson

20070099253 - Method for producing a specific antiserum against the universal tumorous antigen and method for diagnosing malignant tumours using said antiserum: The present invention pertains to the field of medicine and may be used for producing a specific antiserum as well as for carrying out immunological diagnoses of malignant tumours. This method for producing an antiserum involves sampling an embryo at the foetal stage from animals of a same genetic type... Agent: Birch Stewart Kolasch & Birch

20070099250 - Methods for treating proliferative diseases and for monitoring the effectiveness of treatment of proliferative diseases: The present invention relates to phosphoproteins useful as biomarkers for identifying and treating patients suffering from diseases characterized by an aberrant MAP kinase signaling pathway, for example proliferative diseases like certain cancers, monitoring the efficacy of treatment of patients having the disease by administering Raf kinase inhibitors and diagnosing the... Agent: Novartis Corporate Intellectual Property

20070099251 - Tissue-and serum-derived glycoproteins and methods of their use: The present invention is directed generally to tissue-derived glycoproteins and glycosites detectable in plasma via mass spectrometric analysis of glycoproteins from both tissues and blood. The invention also provides methods for identifying tissue-derived glycoproteins and glycosites in plasma, panels of detection reagents for detecting same, as well methods for detecting... Agent: Seed Intellectual Property Law Group PLLC

20070099249 - Compositions and liquid crystals: The present invention relates to compounds, compositions, and methods in the field of detection of analytes. In particular to detection of viruses, cells, bacteria, lipid-membrane containing organisms, proteins, nucleic acids, carbohydrates and other biomolecules, organic molecules and inorganic molecules using a liquid crystal assay format.... Agent: Medlen & Carroll, LLP

20070099248 - Monovalent streptavidin compositions: The invention relates, in part, to monovalent streptavidin compositions. The invention also relates to methods of preparing and using monovalent streptavidin compositions. In some aspects of the invention, the compositions are monovalent streptavidin with a single femtomolar biotin-binding site.... Agent: Wolf Greenfield & Sacks, PC

20070099254 - Polypeptide arrays, methods of polypeptide screening, and mass spectrometric analysis of polypeptides: Embodiments of the present disclosure provide screening methods for identifying target molecules capable of being post-translationally modified.... Agent: Agilent Technologies Inc.

20070099256 - Chemical derivatization, detection, and identification of peptide and protein modifications: Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of peptides using Surface Enhanced Raman Spectroscopy (SERS) and Raman spectroscopy. Additional embodiments provide strategies for chemically derivatizing post-translational modifications and detecting the chemically derivatized products using SERS. Applications of embodiments of the... Agent: Blakely Sokoloff Taylor & Zafman

20070099255 - Diagnostics and therapeutics for diseases associated with n-acetylated alpha-linked acidic dipeptidase 2(naaladase 2): The invention provides a human NAALADASE 2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, neurologcial diseases, urological diseases, respiratory diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological... Agent: Banner & Witcoff, Ltd.

20070099257 - Method for releasing a product comprising chemical oxidation, method for detecting said product and uses thereof: This invention has as its object a method for releasing a product by subjecting a compound of Formula (II′): R′7R′8(HX)C1-C2(YH)R′9R′10 to a chemical oxidation that cleaves the bond C1-C2 to obtain the product. In the compound of Formula (II′): R′7 to R′10, which are identical or different, correspond to a... Agent: Hunton & Williams LLP Intellectual Property Department

20070099258 - Device and method of maintaining sperm motility in a capillary-loaded chamber: The invention relates, generally, to a method of removing sharp edges from a microscope coverslip comprising grinding down the edges and polishing the edges The invention also relates to a device for determining cell motility comprising a slide, a coverslip, comprising at least one edge that has been smoothed and... Agent: Stroock & Stroock & Lavan LLP

20070099259 - Electrochemical assay for the identification of microorganisms: A method for the phenotypic identification of microorganisms is provided. The method is based on the evaluation of the effects of various compounds (effectors) on the respiratory cycle activity of microorganisms. Measurements are based upon the ability of the microorganism to transport electrons to an external chemical oxidant (a mediator)... Agent: Borden Ladner Gervais LLP

20070099260 - Use of a composition which regulates oxidation/reduction reactions intracellularly and/or extracellularly in a staining or sorting process: Improved flow cytometer system particularly adapted to use for sex-selected sperm sorting include enhanced sheath fluid and other strategies which minimize stress on the sperm cells, including a 2.9 percent sodium citrate sheath solution for bovine species and a hepes bovine gamete media for equine species. Improved collection systems and... Agent: Santangelo Law Offices, P.C.

20070099261 - Biosynthesis of isopentenyl pyrophosphate: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the... Agent: Bozicevic, Field & Francis LLP

20070099268 - Chimeric hcn channels: This invention provides a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) polypeptide comprising portions of more than one type of HCN channel. The invention also provides methods of treating a subject afflicted with a cardiac rhythm disorder comprising expression of the chimeric HCN polypeptide in a selected region of the heart so... Agent: Kenyon & Kenyon LLP

20070099267 - Combinatorial protein library screening by periplasmic expression: The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating binding proteins capable of binding small molecules and peptides. In the technique, libraries of candidate binding proteins, such as antibody sequences, are expressed in the periplasm of gram negative bacteria and mixed with a... Agent: Fulbright & Jaworski L.L.P.

20070099269 - Cytokine zalpha11 ligand: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller... Agent: Zymogenetics, Inc. Intellectual Property Department

20070099272 - Expression of granular starch hydrolyzing enzyme in trichoderma: The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity.... Agent: Genencor International, Inc.

20070099263 - Materials and methods relating to g-protein coupled receptor oligomers: The invention provides materials and methods relating to G-protein coupled receptor (GPCR) oligomers. Complexes of two or more GPCRs associated with G-proteins are provided. Also provided are fusion proteins comprising a GPCR and a G-protein, nucleic acids, expression vectors and host cells. Methods of producing the complexes and fusion proteins... Agent: Bozicevic, Field & Francis LLP

20070099264 - Method of posttranslational modification by adding mycrosomal membrane in cell-free protein synthesis: It is intended to provide a novel method for posttranslational modification in cell-free protein synthesis and a novel method for cell-free protein synthesis with the use of such posttranslational modification reaction. A method for synthesizing a protein in a cell-free system using an extract liquid for cell-free protein synthesis containing... Agent: Rader Fishman & Grauer PLLC

20070099274 - Novel human protein kinase, phosphatase, and protease family members and uses thereof: The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin... Agent: Millennium Pharmaceuticals, Inc.

20070099270 - Novel neurotrophic factors: The invention relates to neublastin neurotrophic factor polypeptides, nucleic acids encoding neublastin polypeptides, and antibodies that bind specifically to neublastin polypeptides, as well as methods of making and methods of using the same.... Agent: Fish & Richardson PC

20070099266 - Process for the production of tumor necrosis factor-binding proteins: The invention provides methods for increasing the recombinant production of polypeptides, in particular Tumor Necrosis Factor Binding Proteins, from mammalian cells at a temperature below 30° C.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070099273 - Refolded recombinant beta-secretase crystals and methods for preparing and using the same: The present application relates to methods for growing crystals of both the uncomplexed and complexed forms of β-secretase (BACE) polypeptide. The present application also relates to crystalline forms of uncomplexed BACE and the three-dimensional structure of BACE, as determined from the crystals. In addition, the present application relates to the... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070099265 - Surfactant tolerant cellulase and method for modification thereof: A method for suppressing a reduction in an endoglucanase activity in the presence of a surfactant, characterized by modifying a protein having the endoglucanase activity in which the N-terminus is an amino acid other than pyroglutamic acid, to a protein having the N-terminus of pyroglutamic acid, is disclosed. Further, a... Agent: Sughrue Mion, PLLC

20070099271 - Transductin-1 and transductin-2 and applications to hereditary deafness: The invention provides an isolated or purified nucleic acid molecules consisting essentially of the nucleotide sequence encoding either transductin-1 (TDC1) or transductin-2 (TDC2), related and derivative nucleic acid molecules vectors comprising the isolated or purified nucleic acid sequences, cells comprising such vectors, polypeptides encoded by the nucleic acid molecules, monoclonal... Agent: Leydig, Voit & Mayer, Ltd.

20070099262 - Viral vectors expressing fusion of viral large envelope protein and protein of interest: The present invention provides a virus-like particle (VLP) comprising i) a polypeptide comprising a polypeptide of interest (POI) and at least a particle-associating portion of a large envelope (L) polypeptide of an avian hepadnavirus or a functional derivative or homolog thereof, and ii) a small envelope (S) polypeptide of an... Agent: Scully Scott Murphy & Presser, PC

20070099275 - Compositions, reagents and kits for and methods of diagnosing, monitoring and treating hormonal imbalance: The present invention concerns ten novel variants of alternative splicing of the hormonal imbalance related genes.... Agent: Potter Anderson & Corroon LLP Attn: Kathleen W. Geiger, Esq.

20070099276 - Retrovirus-like particles and retroviral vaccines: The invention relates to retrovirus-like particles having an altered nucleocapsid domain that inhibits packaging of genomic RNA into the retrovirus-like particle, and a protease having reduced enzymatic activity. The invention also provides nucleic acid constructs that encode the retrovirus-like particles. Also provided are immunological compositions, vaccines, and DNA vaccines containing... Agent: Schwegman, Lundberg, Woessner & Kluth/nih

20070099277 - Products and methods for in vivo secretion of monatin: Products and methods for the in vivo production of monatin sweetener are provided. The products include microorganisms that are genetically modified to secrete or to improve secretion of monatin; microorganisms that are genetically modified to produce monatin; and microorganisms that are genetically modified to both secrete or improve secretion of... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070099279 - Microorganisms that extracellularly secrete lipids and methods of producing lipid and lipid vesicles encapsulating lipids using said microorganisms: There are provided microorganisms having a property of producing a lipid containing unsaturated fatty acids as constituent fatty acids and extracellularly secreting the produced lipid encapsulated in lipid vesicles, methods of screening said microorganisms, as well as methods of efficiently producing a fatty acid-containing lipid using said microorganisms. Furthermore, there... Agent: Drinker Biddle & Reath (dc)

20070099280 - Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids: A process for the heterotrophic or predominantly heterotrophic production of whole-celled or extracted microbial products with a high concentration of omega-3 highly unsaturated fatty acids, producible in an aerobic culture under controlled conditions using biologically pure cultures of heterotrophic single-celled fungi microorganisms of the order Thraustochytriales. The harvested whole-cell microbial... Agent: Sheridan Ross PC

20070099278 - Production of biodiesel from combination of corn (maize) and other feed stocks: A method and system to produce biodiesel from a combination of corn (maize) and other agro feedstock may be simarouba, mahua, rice, pongamia etc. Germ is separated (either by wet process or dry process) from corn, crude corn oil extracted from germ and corn starch milk/slurry is heated and cooked... Agent: Palaniswamy Ramaswamy Aare Hig 413,

20070099281 - Novel plasmid vector and transformant stably retaining plasmid: The present invention provides a novel recombinant vector which contains an origin of DNA replication functioning in bacteria of the genus Ralstonia, Cupriavidus or Wautersia. Particularly, the transformant, which is obtained by using a recombinant vector which contains the origin of DNA replication functioning in bacteria of the genus Ralstonia,... Agent: Sughrue Mion, PLLC

20070099282 - Enzyme and methodology for the treatment of a biomass: An enzyme isolated from an extremophilic microbe, and a method for utilizing same is described, and wherein the enzyme displays optimum enzymatic activity at a temperature of greater than about 80 degrees C., and a pH of less than about 2, and further may be useful in methodology including the... Agent: Alan D. Kirsch

20070099283 - Recombinant proteinase k: The invention concerns recombinant proteinase K. Furthermore a method for producing recombinant proteinase K is disclosed, which is characterized in that a) a host cell is transformed with a recombinant nucleic acid which codes for the zymogenic precursor of proteinase K, b) the host cell is cultured in such a... Agent: Roche Diagnostics Corporation

20070099284 - Dehalococcoides isolate for bioremediation: A bacterium, designated BAV 1 belonging to the Pinellas group within the Dehalococcoides cluster has been discovered. BAV 1 is able to completely metabolize chloroethenes to non-toxic products. The isolate is able to grow with dichloroethenes and vinyl chloride (VC) as electron acceptors, reductively dechlorinating dichloroethenes and VC to ethene... Agent: Darby & Darby P.C.

20070099286 - Novel radiation-resistant microorganism: An isolated and purified bacterium is provided which was isolated from a high-level radioactive waste site of mixed waste. The isolate has the ability to degrade a wide variety of organic contaminants while demonstrating high tolerance to ionizing radiation. The organism is uniquely suited to bioremediation of a variety or... Agent: J. Bennett Mullinax, LLC

20070099285 - Novel urethane-bond-degrading bacteria: Microbial biodegradation can be presented as a preferred technique for plastic disposal from the viewpoint of protection of the natural environment, but a problem exists in that plastics are generally not biodegradable. The present invention provides a microorganism capable of degrading a urethane compound and a method for degrading a... Agent: Birch Stewart Kolasch & Birch

20070099287 - Cell picking tool comprising molded with cell-adhesive concave structure and cell handling method: The present invention provides a cell picking tool, etc. The present invention relates to a molded body for cell collection (cell picking tool) with a concave structure capable of picking a cell sheet which has been two-dimensionally cultured in a culture container while keeping the sheet form without using a... Agent: Patterson & Sheridan L.L.P.

20070099288 - Microfluidic methods, devices, and systems for fluid handling: In one aspect of the invention, systems methods, and devices are provided for handling liquid. In some embodiments, such systems, methods, and devices are used to process reagent biochemical reactions.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070099290 - Customizable chip and method of manufacturing the same: The present invention provides an analysis chip allowing customization in accordance with the items required for a given test, and method for producing the same. On a chip (313) there are formed dispensing channels (222) connected to respective detection reservoirs (223) and branching off from a main channel (221). Each... Agent: Scully Scott Murphy & Presser, PC

20070099289 - Device and method for contacting picoliter volumes of fluid: The invention features devices for mixing fluids, e.g., for lysing cells, and methods of use thereof. One device is based on the ability to control the flow of fluids, e.g., by contact angle and channel size. Fluids in this device can be divided to form segments of controlled volume, which... Agent: Clark & Elbing LLP

20070099291 - Ambient pressure monitor and method of preparing biological specimens: A filtration based biological specimen collection and transfer device includes a vacuum source, a vacuum conduit configured to connect the vacuum source to a filter cartridge, an internal pressure monitor configured to measure an apparent pressure inside of the filter cartridge, an internal pressure monitor conduit configured to connect the... Agent: VistaIPLaw Group LLP

20070099292 - Reactor systems having a light-interacting component: Various aspects of the present invention relate to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like. If waveguides are used, they may be fashioned out of any material able to transmit light... Agent: Wolf Greenfield & Sacks, PC

20070099293 - Use of porous membrane to support developing conifer somatic embryos: The present invention provides methods for developing conifer cotyledonary somatic embryos. In some embodiments, the methods of the invention include the step of culturing conifer pre-cotyledonary somatic embryos on a porous membrane, that is at least intermittently contacted with liquid development medium, for a period of time sufficient to produce... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

20070099294 - Materials and methods for cell-based assays: The methods generally relate to three-dimensional culturing of cells with the steps of seeding a cell support structure in a device with at least one vessel for cell culture having a bottom, at least one wall and a cell support structure for three-dimensional cell culture. The cell support structure is... Agent: Calfee Halter & Griswold, LLP

20070099296 - Compositions and methods for determining susceptibility of hepatitis c virus to anti-viral drugs: The present invention provides methods for determining the susceptibility of a pathogenci flavirus to anti-viral compounds. This invention also provides methods for determining anti-viral drug susceptibility in a patient infected with a flavivirus. This invention also provides a method for evaluating the biological effectiveness of a candidate anti-viral drug compound.... Agent: Jones Day

20070099295 - Methods for the determination of antibody igg avidity: The present invention relates to methods of determining anti-infectious agent IgG avidity, for example, human anti-cytomegalovirus and human anti-toxoplasma IgG avidity, using a competitive assay format.... Agent: Robert Deberardine Abbott Laboratories

20070099297 - Primitive and proximal hepatic stem cells: Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal... Agent: Foley And Lardner LLP Suite 500