Chemistry: molecular biology and microbiology inventions 04/07

20070092860 - Sperm suspensions for use in insemination: The present invention provides a method of cryopreserving sperm that have been selected for a specific characteristic. In a preferred embodiment, the method is employed to freeze sex-selected sperm. Although the cryopreservation method of the invention can be used to freeze sperm selected by any number of selection methods, selection... Agent: Santangelo Law Offices, P.C.

20070092865 - Detection and characterization of psychoactives using parallel multi-site assays in brain tissue: This invention relates to methods and devices for the detection and characterization of psychoactive compounds by analyzing alterations of network level physiological characteristics before and after the introduction of a candidate sample onto an in vitro neuronal tissue sample. The invention further provides a software package that enables an operator... Agent: Morrison & Foerster LLP

20070092861 - Environments that maintain function of primary liver cells: Surfaces useful for cell culture comprise a support to which is bound a CAR material, and, bound to the CAR material, an ECM protein, or a biologically active fragment or variant thereof such as elastin, fibronectin, vitronectin, lamninin, collagen I, collagen III, collagen IV, and collagen VI. Also, optionally present... Agent: Becton, Dickinson And Company Alston & Bird LLP

20070092862 - Flow sensors for penile tumescence: The disclosure describes blood flow sensors for detecting penile tumescence. A system according to the invention may include at least one sensor for sensing blood flow into the penis, and one sensor for sensing blood flow away from the penis. Detecting penile tumescence may be accomplished by comparing the flow... Agent: Shumaker & Sieffert, P. A.

20070092863 - Methods and agents of decalcifying bone: Decalcification can be performed by using acid or other agents. It may be difficult to decalcify large bone block within ours. This invention provides a bone-decalcifying agent including a calcium desolving agent for desolving calcium ions of bones, and a bubble-forming agent for generating microbubbles when the bone-decalcifying agent is... Agent: Buchanan, Ingersoll & Rooney PC

20070092864 - Treatment planning methods, devices and systems: Treatment planning methods, devices and systems. One of the treatment planning methods includes displaying at least a portion of a set of lungs and one or more potential treatment regions; receiving a selection of a target treatment region from among the one or more potential treatment regions; and displaying one... Agent: Fulbright & Jaworski L.L.P.

20070092867 - Application using non-covalent bond between a cucurbituril derivative and a ligand: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070092866 - Avian adenoassociated virus and uses thereof: The present invention provides an Avian adeno-associated virus (AAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAAV vectors and particles. Methods of isolating the AAAV are provided.... Agent: National Institute Of Health C/o Needle & Rosenberg, P.C.

20070092870 - Detection of biomolecules: Compositions, systems and methods for the detection of analytes with labeled nanostructures are provided. In particular, compositions and systems including labeled nanostructures for detecting a biomolecule of interest, and methods of use thereof, are provided.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070092868 - Liquid crystal cassette: A functional cassette for the detection of ligands comprises a first inner housing, a second middle housing and a third outer housing and each housing is at least partially rotatable relative to an adjoining housing. The first inner housing contains a central well adapted for receiving a sample, and the... Agent: Hahn Loeser & Parks, LLP

20070092871 - Microarray for pathogen identification: There is disclosed a microarray device for pathogen identification and for subtyping influenza A. Pools of primers are disclosed and used to amplify any subtype of influenza A. Pathogen identification includes influenza A, influenza B, parainfluenza virus, adenovirus, enterovirus, rhinovirus, human metapneumovirus, respiratory syncytal virus, herpes simplex viruses, SARS coronavirus,... Agent: Combimatrix Corporation

20070092869 - Spike-in controls and methods for using the same: Methods, compositions, and kits for performing a one-color analysis of microarray data are provided. Also disclosed are compositions including control nucleic acid sequences, and methods for measuring the dynamic range of a microarray analysis.... Agent: Agilent Technologies Inc.

20070092882 - Analysis of microrna: Methods are described in which a sample containing miRNA is contacted with an array having a probe set, followed by interrogating the array to assess binding to the probe set. Probes, probe sets, arrays comprising a probe set, and kits incorporating the probe sets are also described.... Agent: Agilent Technologies Inc.

20070092872 - Apparatus and method for sequencing a nucleic acid: Disclosed herein are methods and apparatuses for sequencing a nucleic acid. These methods permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides.... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20070092901 - Automated sample-to-microarray system: An apparatus having within or as part of a housing; a sample port; a microarray port; a lysis module; a purification module for containing a solid phase for binding of oligonucleotides; a thermocycling module for containing a polymerase chain reaction; a fragmentation module; and a microarray module for holding a... Agent: Naval Research Laboratory Associate Counsel (patents)

20070092877 - Bcrm-1 genes and uses thereof: A polypeptide capable of conferring multidrug-resistance on a cell is disclosed. Also disclosed are nucleic acids encoding the polypeptide, expression vectors, trasformant host cell lines expressing the polypeptide, and antibodies binding to the polypeptide. Screening, diagnostic and treatment methods using the above polypeptide, nucleic acids, antibodies and host cell lines... Agent: Fish & Richardson PC

20070092905 - Compositions and methods for analyzing immobilized nucleic acids: The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using... Agent: Bozicevic, Field & Francis LLP

20070092898 - Detection of multiple anti-viral antibodies: The present invention relates to methods and kits for the diagnosis and monitoring of hepatitis C virus (HCV) infection and/or Kaposi's sarcoma herpesvirus infection (KSHV) in a subject, as well as other infectious diseases and agents. In particular, the present invention relates to the diagnosis and monitoring of infectious disease... Agent: Medlen & Carroll, LLP

20070092888 - Diagnostic markers of hypertension and methods of use thereof: The present invention relates to methods for the diagnosis and evaluation of cardiovascular illness, particularly hypertension treatment. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for hypertension treatment and one or more non-specific... Agent: William C. Fuess

20070092873 - Digital identification of genetic materials and methods for acquiring data for it: The present invention relates to methods using HIPK1 sequences for use in diagnosis and treatment of lymphoma and leukemia. In, addition, the present invention describes the use of these compositions for use in screening methods.... Agent: Paul & Barbara Gentry

20070092896 - Extreme thermophile single-stranded dna binding mutant protein, and nucleic acid isothermal amplification method of use thereof: The invention establishes a technology that allows non-specific amplification to be inhibited during nucleic acid amplification in an isothermal amplification reaction, such that the amplification efficiency is increased. The invention is a extreme thermophile single-stranded DNA binding mutant protein, having an amino acid sequence that expresses a function that can... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070092879 - Fluoresence-based dna primase assays: The present invention provides methods for assaying the activity of DNA primases and methods for screening for compounds that modulate the activity of DNA primases.... Agent: Astrazeneca R&d Boston

20070092881 - Gene markers of tumor metastasis: The invention concerns the study of tumor metastasis in a NOD/SCID/γcnull transgenic mouse model and the identification of tumor markers, including markers of tumors with high metastatic potential, using information obtained in this mouse model.... Agent: Heller Ehrman LLP

20070092878 - In vitro method to detect bladder transitional cell carcinoma: The present invention refers to an in vitro method to detect a bladder transitional cell carcinoma, in an individual, to determine the stage or severity of this cancer in an individual or to monitor the effect of therapy administered to an individual with this cancer; to screen for, identify, develop... Agent: Kramer & Amado, P.C.

20070092880 - Invasive cleavage reaction with electrochemical readout: A universal tag assay is disclosed wherein at least one invasive cleavage reaction (ICR) is used to generate tagged molecules having identifier tags corresponding to target nucleotide sequences, and further wherein hybridization of any tagged molecule with a complementary detection probe on a universal detector indicates the presence of the... Agent: Knobbe Martens Olson & Bear LLP

20070092897 - Labeled probe bound object, method for producing the same and method for using the same: A method for labeling an object, which is effective when multiple types of labels are given as necessary even to a very small object such as a fine particulate substrate for use in fixation of biological substances such as probe molecules or nucleic acid primers that are used for a... Agent: Fitzpatrick Cella Harper & Scinto

20070092875 - Map2k6 as modifier of branching morphogenesis and methods of use: Human MAP2K6 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MAP2K6 are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20070092876 - Method and system for cell and/or nucleic acid molecules isolation: The present invention relates to methods and system for tissue cell and/or nucleic acid molecule isolation. In particular, to a method for isolating nucleic acid molecules from tissue samples comprising: i) treating a tissue sample with at least one enzyme for tissue dissociation; ii) adding a lytic solution; and iii)... Agent: Ostrolenk Faber Gerb & Soffen

20070092906 - Method and system for delivering nucleic acid into a target cell: Controlled delivery of nucleic acid into adhered of cells is achieved by immobilizing the nucleic acid and the cells to a substrate. Improved control over delivery is achieved by immobilizing the nucleic acid to the substrate via complimentary DNA binding interactions with an oligonucleotide linker.... Agent: Quarles & Brady LLP

20070092884 - Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a bac-based dna library: application to the detection of mycobacteria: A method for detecting Mycobacterium tuberculosis involves contacting a biological sample with the product of expression of at least one ORF contained in a polynucleotide present in Mycobacterium tuberculosis and absent in Mycabacterium bovis BCG; and detecting whether an immunological complex is formed between the product thereof and antibodies contained... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070092904 - Method for preparing limiting quantities of nucleic acids: The present invention relates generally to the amplification of nucleic acids. More specifically, the present invention facilitates amplification of total RNA for a variety of purposes, including analysis utilizing nucleotide assays, constructing cDNA libraries, in situ hybridization, and TaqMan. Additionally, the present invention facilitates amplification of total RNA isolated from... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.

20070092890 - Methods and compositions for detecting autoimmune disorders: The invention provides methods and compositions useful for detecting autoimmune disorders.... Agent: Genentech, Inc.

20070092886 - Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease: Polynucleotide sequences are provided that correspond to genes that are differentially expressed in atherosclerotic disease conditions. Methods for using these sequences to detect gene expression and/or for transcriptional profiling in mammals are also provided. The polynucleotide sequences of the invention may be used, for example, to diagnose atherosclerotic disease, to... Agent: Morrison & Foerster LLP

20070092891 - Methods and compositions for identifying biomarkers useful in diagnosis and/or treatment of biological states: The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological... Agent: Wilson Sonsini Goodrich & Rosati

20070092892 - Methods and compositions for identifying biomarkers useful in diagnosis and/or treatment of biological states: The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological... Agent: Wilson Sonsini Goodrich & Rosati

20070092893 - Methods and compositions for identifying cancer-related biomarkers: The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological... Agent: Wilson Sonsini Goodrich & Rosati

20070092894 - Methods and kits for detecting single nucleotide polymorphisms of chromosome implicated in premature canities: Methods and kits for diagnosing a predisposition to premature canities in an individual are disclosed. A method for diagnosing a predisposition to premature canities in an individual comprises detecting at least one SNP marker of the human chromosome 9, selected from the group consisting of rs306534, rs3739902, rs575916, and rs365297.... Agent: Buchanan, Ingersoll & Rooney PC

20070092902 - Methods for detection of promoter polymorphism in ugt gene promoter: The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon... Agent: Fulbright & Jaworski L.L.P.

20070092900 - Methods for diagnosing and characterizing breast cancer and susceptibility to breast cancer: Methods and kits for diagnosing and characterizing breast cancer or a susceptibility to breast cancer are described herein. Diagnosis and characterization methods comprise detecting the BARD1 Cys557Ser allele or a haplotype comprising the BARD1 Cys557Ser allele in patients with or without a familial predisposition to cancer. The methods described herein... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070092887 - Methods for generating polynucleotides having desired characteristics by iterative selection and recombination: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to... Agent: Maxygen, Inc. Intellectual Property Department

20070092895 - Methods for identifying genes that increase yeast stress tolerance, and use of these genes for yeast strain improvement: Disclosed are methods for identifying genes that increase stress tolerance of yeast, list of identified genes, and use of these genes for improving yeast strains for better survival and performance during ethanolic fermentation.... Agent: Nath & Associates

20070092907 - Methods of screening compound probes: Briefly described, embodiments of this disclosure include methods for identifying compound probe candidates, methods of screening compound probe candidates, methods of preparing molecular imaging probes, high throughput methods for identifying molecular imaging probes in a library, and the like.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070092883 - Methylation specific multiplex ligation-dependent probe amplification (ms-mlpa): An improved multiplex ligation-dependent amplification method is disclosed for detecting the presence of specific methylated sites in a single stranded target nucleic acid, while simultaneously, the quantification of the target nucleic acid sequence can be performed, using a plurality of probe sets of at least two probes, each of which... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070092909 - Molecular markers for identification of fat and lean phenotypes in chickens: The invention provides molecular methods of screening chickens to determine those more likely to have a lean or fat phenotype by identifying the presence of at least one polymorphism in genetic material of a chicken in the thyroid hormone repressible gene (THRG) or its 3′ untranslated region (SEQ ID NO:... Agent: Connolly Bove Lodge & Hutz LLP P.o. Box 2207

20070092899 - Multiple displacement amplification with blocker dna: A method of whole genome amplification of a nucleic acid sample comprising providing a starting template of the nucleic acid sample, bringing the template together with blocking DNA, bringing the template together with DNA polymerase, and multiple displacement amplification of the template. The method can be used with a starting... Agent: Eddie E. Scott

20070092903 - One-color microarray analysis methods, reagents and kits: Microarray platforms for performing one-color and two color analyses using a single platform are provided. Methods of using the microarray platforms and analyzing data obtained from such microarrays are also provided.... Agent: Agilent Technologies Inc.

20070092889 - Parkinson's disease-related disease compositions and methods: Compositions and methods for use in the therapeutic and preventative treatment, study, diagnosis and prognosis of PD-related disease are disclosed. Also provided are kits and reagents for prognosis and diagnosis of PD-related disease and related conditions.... Agent: Perlegen Sciences, Inc. Legal Department

20070092874 - Plasma or serum marker and process for detection of cancer: This disclosures provides, in one aspect, a method for detecting non-clinically diagnosed cancer in a patient. In one embodiment, the method includes extracting blood serum or plasma from the patient, and then detecting beta-catenin RNA in the blood serum or plasma. In addition, in this embodiment, the method includes determining... Agent: Baker & Mckenzie LLP

20070092908 - Renaturation, reassociation, association and hybridization of nucleic acid molecules: The present invention features methods and compositions for the renaturation, hybridization, association, or reassociation of nucleic acids that combines both acceleration of the reaction rate and improved specificity.... Agent: Bozicevic, Field & Francis LLP

20070092885 - Secreted proteins: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.... Agent: Foley And Lardner LLP Suite 500

20070092910 - Alcohol dehydrogenase sequences useful for developing compounds for the prevention and/or treatment of metabolic diseases: The present invention relates to nucleotide sequences, particularly those of SEQ ID NO's 2, 7 and 9 that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds for the prevention and treatment of metabolic diseases such as diabetes and... Agent: Wolf Greenfield & Sacks, PC

20070092914 - Compartmentalised screening by microfluidic control: The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070092911 - Methods and compositions for diagnosis and /or prognosis in systemic inflammatory response syndromes: The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, septic shock and/or MODS from each other and/or... Agent: Barry S. Wilson Foley & Lardner LLP

20070092913 - Methods for identifying agents that modulate gpr105 activity: In one aspect, the present invention provides methods for determining whether a chemical agent modulates the biological activity of a GPR105 protein. The methods of this aspect of the invention include the steps of: (a) contacting a living cell, in vitro, with a chemical agent, wherein the living cell expresses... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20070092912 - Uses of human zven antagonists: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070092917 - Biomarkers for screening, predicting, and monitoring prostate disease: Gene expression data are analyzed using learning machines such as support vector machines (SVM) and ridge regression classifiers to rank genes according to their ability to separate prostate cancer from BPH (benign prostatic hyperplasia) and to distinguish cancer volume. Other tests identify biomarker candidates for distinguishing between tumor (Grade 3... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20070092918 - C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof: A novel gene (designated PC-LECTIN) that is highly overexpressed in prostate cancer and its encoded protein is described. PC-LECTIN in normal human tissues is restricted to testis, but is highly expressed in prostate cancer. Consequently, PC-LECTIN provides a diagnostic and/or therapeutic target for prostate cancer.... Agent: Agensys C/o Morrison & Foerster LLP

20070092916 - Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor: The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20070092915 - Method and composition for analyzing a carbohydrate polymer: Disclosed is a method for characterizing carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070092919 - Monitoring of liquids for disease-associated materials: A method for monitoring liquids for the presence of disease-associated materials, so as to provide a non-invasive means for the detection of various materials associated with cancer, autoimmune, neuro-degenerative and other disorders. The method provided comprises contacting a sample of the liquid with a solid, non-buoyant particulate material having free... Agent: Beyer Weaver LLP

20070092921 - Monoclonal and polyclonal antibodies to equine albumin and hemoglobin and apparatus and methods using the antibodies in the identification and localization of ulcers and other digestive tract bleeding in equines: A diagnostic and testing apparatus and related methods for the use of the same are disclosed which derive and use antibodies to equine albumin and equine hemoglobin in testing apparatus, kits, and methods for detecting and localizing gastric and colonic ulcers or bleeding in horses. Fecal droppings from a horse... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator

20070092920 - Serum prolactin binding protein in epithelial carcinoma: The present invention relates to antibodies that have specificity towards prolactin binding protein (PRLBP) that is either bound to a binding partner or unbound to a binding partner, as well as antibodies towards PRLBP regardless of the binding state of PRLBP. The present invention also provides methods of using these... Agent: Invitrogen C/o Intellevates Sughrue Mion PLLC

20070092922 - Taxol immunoassay: Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for the quantification and monitoring of taxol in biological fluids.... Agent: Gibbons P.C.

20070092923 - Establishing a long-term profile of blood sugar level aiding self-control of the same: Establishing a long-term profile of blood sugar level aiding self-control of the same includes periodically obtaining a specimen from a patient, and detecting a response of the specimen. Obtaining a blood sugar value of the patient based on the response, and storing the blood sugar values periodically measured. Establishing a... Agent: Berkeley Law & Technology Group, LLP

20070092926 - Analysis of protein isoforms using unique tryptic peptides by mass spectrometry and immunochemistry: A method for qualitatively and quantitatively detecting a protein isoform (p450 isozyme) in a sample using MALDI-TOF mass spectrometry or immunochemistry using a unique proteolytic peptide for the isoform. Relative and absolute quantitation can be performed using calibration curves with P450 isozyme-specific peptide standards.... Agent: Stinson Morrison Hecker LLP Attn: Patent Group

20070092925 - Method of treating skin by delivering specific protein stabilizers/protectors to skin proteins and methods of selecting said stabilizers: The invention provides methods of treating skin by delivering specific protein stabilizers/protectors to skin proteins, as well as to methods of selecting said stabilizer.... Agent: Unilever Intellectual Property Group

20070092924 - Process for treatment of protein samples: The process of the invention comprises 1) preparing a dry porous support incorporating one or more biomolecule-modifying reagents, 2) applying a biomolecule-containing sample solution to said support wherein the volume of said sample is equal to or less than the imbibition capacity of said support so that the sample is... Agent: Hendricks And Associates

20070092927 - Photocatalytic particles with directed and controlled redox activity: A modified particle. The modified particle comprises: a semiconductor particle which is photoactivatable; and a modifier molecule attached to the semiconductor particle, wherein the modifier molecule includes an electrochemically reversible redox active site which is photoexcitable. Bioconjugated nanoparticle probes, Redox-NSs and methods of using these modified particles are also described.... Agent: Dinsmore & Shohl LLP

20070092928 - Method of evaluating elimination of microoganisms and apparatus for evaluating elimination of microorganisms: The sterilizing effect of particle irradiation on microorganisms for the sterilizing treatment thereof can be evaluated. The evaluation can be done by supplying microorganisms in the space inside a container (8), allowing particles (7) for the sterilizing treatment of microorganisms to irradiate the microorganisms, sampling the microorganisms by a sampling... Agent: Birch Stewart Kolasch & Birch

20070092929 - Test system for the determination of the presence of an antibiotic in a fluid: Provided is a test system, a test method and a test kit based on a test medium comprising Bromothymol Blue or a structurally related indicator.... Agent: Nixon & Vanderhye, PC

20070092930 - Process for enhanced recovery of crude oil from oil wells using novel microbial consortium: The present invention provides a microbial consortium containing three hyperthermophilic, barophilic, acidogenic, anaerobic bacterial strains for enhanced oil recovery from oil reservoirs where temperatures range from 70° C. to 90√ C. The said microbial consortium is unique in producing a variety of metabolic products mainly CO2, methane, biosurfactant, volatile fatty... Agent: Birch Stewart Kolasch & Birch

20070092931 - Biosynthesis of isopentenyl pyrophosphate: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the... Agent: Bozicevic, Field & Francis LLP

20070092932 - Method of producing xanthophyll: The present invention provides a method for producing a xanthophyll from a photosynthetic microalga, which includes inoculating a photosynthetic microalga containing a xanthophyll, preferably an encysted microalga, into a nutrient medium to grow the microalga; and encysting the grown microalga, by a single-step culture method in which the growth step... Agent: Le-nhung Mcleland

20070092940 - Cysteine engineered antibodies and conjugates: e

20070092938 - Diagnostics for sars virus: This invention relates to Severe Acute Respiratory Syndrome associated coronavirus (SARS virus) isolated and recombinant proteins, in particular the nucleocapsid (N) protein and spike (S) protein, as well as fragments thereof and their use in the diagnosis, treatment and prevention of Severe Acute Respiratory Syndrome (SARS). The proteins and fragments... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070092939 - Human immunodeficiency virus entry inhibitor assay: The present invention is a method for evaluating the ability of a compound to prevent the Human Immunodeficiency Virus (“HIV”) from entering into a T cell. The method involves fusing a first cell line that mimics HIV viral particles by expressing a gp120-gp41 complex on the cell surface and that... Agent: Cheryl Liljestrand Tanox, Inc.

20070092944 - Hybrid glycosylated products and their production and use: The present invention relates to hybrid glycosylated products, and in particular, to natural products such as polyketides and glycopeptides, and to processes for their preparation. The invention is particularly concerned with recombinant cells in which a cloned microbial glycosyltransferase can be conveniently screened for its ability to generate specific glycosylated... Agent: Dann, Dorfman, Herrell & Skillman

20070092937 - Method of producing target protein, fusion protein and gene thereof, protein consisting of partial sequence of intein and gene thereof, expression vector, and transformant: It is intended to provide techniques whereby a target protein is efficiently obtained as a normal protein even in the case of a protein which can be hardly expressed by usual recombinant DNA techniques. A fusion protein composed of a molecular chaperone, an intervening protein having an activity of cleaving... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070092935 - Novel bacillus bagcel cellulase: The present invention provides a novel cellulase nucleic acid sequence, designated BagCel, and the corresponding BagCel amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BagCel, recombinant BagCel proteins and methods for producing the same.... Agent: Genencor International, Inc. Attention: Legal Department

20070092934 - Novel bacillus mhkcel cellulase: The present invention provides a novel cellulase nucleic acid sequence, designated mHKcel, and the corresponding mHKcel amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding mHKcel, recombinant mHKcel proteins and methods for producing the same.... Agent: Victoria L Boyd Genencor International Inc

20070092946 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070092945 - Phospholipase: The present invention is related to a method for producing a phospholipase by processing an expressed fungal peptide and to certain specified phospholipases. Furthermore the invention provides a method for producing cheese with a phospholipase.... Agent: Novozymes North America, Inc.

20070092941 - Pro1298 polypeptides: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Heller Ehrman LLP

20070092933 - Production of multimeric fusion proteins using a c4bp scaffold: The present invention provides a method for obtaining a recombinant fusion protein comprising a scaffold of a C-terminal core protein of C4bp alpha chain, said recombinant fusion protein being capable of forming multimers in soluble form in a prokaryotic host cell, the method including the steps of (i) providing a... Agent: Nixon & Vanderhye, PC

20070092936 - Severe acute respiratory syndrome: The present invention relates, in general, to severe acute respiratory syndrome and, in particular, to a method of generating neutralizing antibodies to the virus. The invention further relates to methods of detecting the presence of the virus and to methods of treating infected individuals.... Agent: Nixon & Vanderhye, PC

20070092942 - Ubiquitin specific enzymes of family herpesviridae: Disclosed is a new class of deubiquitinating enzymes that are conserved across the family Herpesviridae.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070092943 - Versatile vectors for expression of foreign proteins in photosynthetic bacteria: Methods for expressing and purifying foreign (heterologous) proteins in photosynthetic organisms employ expression of both heterologous membrane proteins and a means for compartmentalizing or sequestering of the protein.... Agent: Barnes & Thornburg LLP

20070092947 - Methods and compositions for increasing longevity and protein yield from a cell culture: Disclosed herein are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. By transfecting cells in culture with an apoptosis-inhibiting gene or vector, cells in culture... Agent: Faegre & Benson LLP Patent Docketing

20070092948 - Novel human kunitz-type inhibitors and methods relating thereto: The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the... Agent: Zymogenetics, Inc. Intellectual Property Department

20070092949 - Method of converting beta-1,4-glucan to alpha-glucan: A method for production of an α-glucan from a β-1,4-glucan is provided, comprising: reacting a solution containing β-1,4-glucan, a primer, a source of phosphoric acid, β-1,4-glucan phosphorylase, and α-1,4-glucan phosphorylase to produce an α-glucan. In this method, said β-1,4-glucan may be cellobiose, and said β-1,4-glucan phosphorylase may be cellobiose phosphorylase.... Agent: Mark D. Saralino (general) Renner, Otto, Boisselle & Sklar, LLP

20070092950 - Process for preparing l-threonine: The invention provides an improved process for the fermentative preparation of L-threonine using L-threonine-producing bacteria from the family Enterobacteriaceae.... Agent: Fitch, Even, Tabin & Flannery

20070092951 - Alleles of the zwf gene from coryneform bacteria: The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.... Agent: Law Office Of Michael A. Sanzo, LLC

20070092952 - Glutamate 2,3-aminomutases and methods of use thereof: There are provided nucleic acids, including isolated DNA molecules, which encode glutamate 2,3-aminomutase enzymes, polypeptides produced from such nucleic acids and methods of making the nucleic acids and polypeptides. There are further provided methods of producing β-glutamate from glutamate using glutamate 2,3-aminomutase.... Agent: Foley & Lardner LLP

20070092953 - Method for producing l-glutamine by fermentation and l-glutamine producing bacterium: L-Glutamine is produced by culturing a coryneform bacterium which has L-glutamine producing ability and has been modified so that its intracellular glutamine synthetase activity should be enhanced, preferably which has been further modified so that its intracellular glutamate dehydrogenase activity should be enhanced, in a medium to produce and accumulate... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070092954 - Production of polyketides: Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.... Agent: Townsend And Townsend And Crew, LLP

20070092955 - Fermentative production of lipids on an industrial scale using chemically defined media: We describe the use of chemically defined media for the fermentative production of valuable compounds on an industrial scale. Microbial strains which are suitable for fermentation on an industrial scale using a chemically defined medium include fungal, yeast and bacterial strains. Suitable strains can be obtained as wild type strains... Agent: Nixon & Vanderhye, PC

20070092956 - Methods and materials for the production of organic products in cells of candida species: The present invention relates to biocatalysts that are cells, optimally of the Crabtree-negative phenotype, comprising expression vectors encoding genes heterologous to the cell that enable increased production of organic products. More specifically, the invention relates to genetically modified Candida cells, methods for making the Candida cells, and their use in... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070092957 - Fermentive production of four carbon alcohols: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070092958 - Method and apparatus for guiding growth of neurons: This invention pertains to a method and apparatus for facilitating guided growth of axons and dendrites in cell culture, for example for studies of axonal pathfinding, target cell selection, synapse formation, synaptic physiology, neuronal plasticity, drugs screening and gene perturbations. In a preferred embodiment, the invention includes a semiconducting substrate... Agent: Fish & Richardson P.C.

20070092959 - Removal of plasmin(ogen) from protein solutions: A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms,... Agent: Jacobson Holman PLLC

20070092960 - Method for high throughput volumes in the fractionation of bio-molecules by chromatographic systems: The present invention provides industrial scale expanded bed adsorption process for fractionation and isolation of bio-molecules from fluids, preferably proteins from milk and whey, in a cost-effective manner. This is accomplished by operating the expanded bed column at high temperatures of at last 40° C., combined with applying flow rates... Agent: Foley And Lardner LLP Suite 500

20070092961 - Process to cultivate brevundimonas diminuta for filtration validation: The present invention relates to a method for culturing Brevundimonas diminuta for filtration validation. The method comprises inoculating the B. diminuta cells in an appropriate medium, growing the inoculated medium in a gas-impermeable chamber, wherein there is room for air in the headspace of the chamber, wherein air is continually... Agent: Merck And Co., Inc

20070092962 - Carbon neutralization system (cns) for co2 sequestering: A device and method for carbon dioxide sequestering involving the use of a photo-bioreactor with Light Emitting Diodes (LED's) for the cost-effective photo-fixation of carbon dioxide (CO2). This device and method is useful for removing undesirable carbon dioxide from waste streams.... Agent: Bracewell & Giuliani LLP

20070092963 - Device to the preparation of cutting edge capable samples: A device for the processing of samples which can be cut, in particular histological tissue samples, where the device comprises a processing tray (1) with a processing surface (2) and with at least two trimming inserts (3) for laying in and cutting the samples by means of knives, is characterized... Agent: Alston & Bird LLP

20070092964 - Ion detection using a pillar chip: The present invention provides methods and assemblies for ion detection of samples using a chip with elevated sample zones. The elevated sample zones provide a number of ion detection advantages over chips with non-elevated sample zones. Embodiments of the invention have a number of applications in drug discovery, environmental analyses... Agent: Townsend And Townsend And Crew, LLP

20070092965 - Culture of goblet cells: The invention encompasses isolation, culture and characterization of goblet cells in vitro from mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans, rats, mice, rabbits and the like. In another aspect of the invention, the culture of goblet cells has a concentration of pure... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20070092966 - In vitro tumor angiogenesis model: Provided is a method of inducing tubulogenesis in normal endothelial cells comprising co-culturing the normal endothelial cells with tumor cells and forming tubules from the normal endothelial cells.... Agent: David W. Highet, Vp And ChiefIPCounsel Becton, Dickinson And Company

20070092967 - Method of isolating and culturing mesenchymal stem cell derived from umbilical cord blood: The present invention relates to a method of isolating and culturing mesenchymal stem cells using umbilical cord blood that is most ideal for cell therapy. The method comprises adding an anti-coagulant to umbilical cord blood having a volume of more than 45 ml per unit, which is obtained within 24... Agent: Venable LLP

20070092968 - Novel htmc promoter and vectors for the tumor-selective and high-efficient expression of cancer therapeutic genes: Promoters that include a tissue-selective promoter sequence and a second promoter sequence operatively coupled to the tissue-selective promoter sequence, wherein the second promoter sequence includes a minimal viral promoter sequence, are disclosed. Nucleic acids and compositions that include these promoter sequences are also disclosed. Also disclosed are methods of improving... Agent: Fulbright & Jaworski L.L.P.

20070087320 - Medium for conservation of organs, biological tissues or living cells: The object of the present invention is a preservation medium for living organs, biological tissues, and cells containing a liquid nutritive base, wherein it contains a high-molecular-weight hyaluronic acid and sodium chloride and wherein it contains no component of animal origin.... Agent: Clark & Brody

20070087321 - Post-thaw survival of chryopreserved biological material by hydrostatic pressure challenge: The present invention relates to a method for improving post-thaw survival of cryopreserved biological material comprising applying hydrostatic pressure to said biological material; keeping the said biological material at the hydrostatic pressure for a predetermined time period; releasing the hydrostatic pressure; and freezing the said biological material using any protocol... Agent: Hahn & Voight PLLC

20070087322 - Method of preserving early embryos of experimental animals by vitrification: This invention provides a solution for preserving mammalian early embryos or ES cells by vitrification, which comprises, as a base material, a phosphate buffer that exclusively contains 10% to 15% (v/v) propylene glycol as polyhydric alcohol or a phosphate buffer that exclusively contains 10% to 15% (v/v) propylene glycol and... Agent: Heller Ehrman LLP

20070087324 - Method of providing readily available cellular material derived from peripheral blood: Process for preparing a peripheral blood cell composition in a TVEMF-bioreactor.... Agent: Ladas & Parry LLP

20070087323 - Sampling system: A device for collecting and storing a biological sample for subsequent analysis, comprising tamper-evident storage means for storing said sample, said storage means being suitable for digestion together with said biological sample.... Agent: Fulbright & Jaworski L.L.P.

20070087327 - Method and kit-of-parts for the electrophysiological examination of a membrane comprising an ion channel: The invention relates to a collection (kit-of-parts) for producing a high electrical resistance in an electrophysiological examination of a membrane comprising an ion channel, comprising a first electrolytic solution and a second electrolytic solution, wherein the first electrolytic solution comprises 20-140 mM divalent cations of a first element and the... Agent: Ip Strategies

20070087328 - Method of coating lipid membranes: Method for the manufacturing of a supported lipid membrane comprising: providing a substrate, covered at least in part with a layer comprising proteins, glycoproteins, polypeptides and/or peptides; contacting and incubating said substrate with a solution comprising bicelles, which comprise at least one short chain and at least one long chain... Agent: Fulbright & Jaworski L.L.P.

20070087326 - Method of measuring the biological activity of an urotensin ii receptor: Administration of U-II to a cell having a functional urotensin II receptor caused an increase in the electrical impedance of the cell in a receptor specific and dose dependent manner. Thus, the present invention provides methods of measuring the biological activity of an U-II receptor by monitoring the electrical impedance... Agent: Philip S. Johnson Johnson & Johnson

20070087325 - Method of screening for cell colonies that express a soluble variant of a target protein: The present invention concerns a method of identifying a cell colony which expresses a soluble variant of a target protein which method comprises (a) subjecting the cell colony to conditions which are capable of causing lysis thereof; (b) filtering the lysate through a filter having pores which allow only soluble... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070087329 - Serum replacement for thyroid hormone-responsive cell culture: A low thyroid hormone serum supplemented culture medium is provided comprising serum prepared from non-mammalian vertebrates having a developmental stage with low endogenous thyroid hormone (T3 and T4) levels; and a culture medium. The culture medium is for the study of cellular responses to thyroid hormones or chemicals that induce... Agent: Klarquist Sparkman, LLP

20070087336 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Medlen & Carroll LLP

20070087337 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Medlen & Carroll LLP

20070087338 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Medlen & Carroll LLP

20070087339 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Medlen & Carroll LLP

20070087340 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Medlen & Carroll LLP

20070087341 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Medlen & Carroll LLP

20070087335 - Human microrna targets in hiv genome and a method of identification thereof: The present invention relates to human microRNA targets in HIV genome and a method of identification thereof. Using multiple software targets to six human microRNAs [miRNAs] were discovered in the net, vpr, env, and I vif genes. The miRNAs were identified as hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-mir-149, hsa-mir-324-5p, hsa-mir-378. These miRNAs... Agent: Harness, Dickey & Pierce, P.L.C

20070087333 - Method to detect antigen-specific cytolytic activity: The invention relates to a novel non-radioactive method to detect cytolytic activity that provides a measure of the existence and magnitude of an immune response against a particular antigen or immunogen. Provided is a method for detecting cytolytic activity of cells or a substance against a population of target cells,... Agent: Trask Britt

20070087334 - Pkr activation via hybridization chain reaction: The present application relates to the use of hybridization chain reaction (HCR) to form double stranded RNA polymers in the presence of a target, such as a nucleic acid associated with a disease or disorder. The RNA polymers are preferably able to activate the RNA-dependent kinase PKR. Activation of PKR... Agent: Knobbe Martens Olson & Bear LLP

20070087332 - Pulmonary stem cells, related methods and kits of parts: Isolated pulmonary stem cells, the isolated pulmonary stem cells being slowly dividing Oct-4 expressing cells forming individual colonies and able to undergoing terminal differentiation into a mature phenotype in vitro; a method to identify stem cells of a tissue; a kit for the identification of stem cell of a tissue;... Agent: Greenberg Traurig LLP

20070087331 - Selection of b cells with specificity if interest: method of preparation and use: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides methods using a composition comprising an ordered and repetitive antigen or antigenic determinant array for visualization and selection of B cells specific for the antigen. These B cells are useful for the... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070087330 - Viral deconstruction through capsid assembly in vitro: A cell-free method for translation and assembly of viral capsid and capsid intermediates is disclosed for use in deconstructing an unknown virus and for screening for compounds that inhibit assembly of viral capsids for the unknown virus.... Agent: Jonathan Alan Quine The Quine Intellectual Property Law Group, P.C.

20070087345 - Assays for the direct measurement of gene dosage: The present invention relates to compositions, methods, and kits for quantifying variations in gene copy number, e.g., of individual genes or of chromosomes or portions of chromosomes in an homogeneous reaction, without the need for target amplification, fragment size resolution, or microscopy.... Agent: Medlen & Carroll, LLP

20070087355 - Comparative genomic hybridization assays and compositions for practicing the same: Comparative genomic hybridization (CGH) assays and compositions for use in practicing the same are provided. Aspects of the methods include first preparing genomic templates from an initial genomic source by using precursors of circular template nucleic acids, e.g., padlock probes. The precursors include first and second domains that are at... Agent: Agilent Technologies Inc.

20070087359 - Detecting mutations in the feline cardiac myosin binding protein c gene associated with hypertrophic cardiomyopathy in cats: The invention pertains to methods for detecting the presence or absence of a mutation associated with hypertrophic cardiomyopathy in cats, particularly domesticated cats, and more particularly Maine Coon cats. The methods include detecting the presence or absence of a mutation in the feline MYBPC gene, and identifying feline subjects that... Agent: Calfee Halter & Griswold, LLP

20070087347 - Dose-dependent promoter originating in humans: It was found that a DNA consisting of a nucleotide sequence as set forth in SEQ ID NO: 1 having one sequence (SEQ ID NO: 2) unit, has a function of an initiator or a promoter. Therefore, it is provided a DNA consisting of a nucleotide sequence as set forth... Agent: Kilyk & Bowersox, P.l.l.c.

20070087366 - Functional mutant loxp sequences and uses thereof: The invention provides methods, kits, and compositions comprising novel mutant loxP sites. Such sites are particularly useful for procedures requiring multiple site-specific recombination reactions, including deletions or insertions of multiple genes or other sequences in the same organism, staged insertions or deletions of genes of the same organism at different... Agent: Stephen C. Macevicz Technology Development Office

20070087349 - Highly parallel template-based dna synthesizer: The invention relates to a template-based method for preparing nucleic acid double strands.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070087356 - In situ assembling of protein microarrays: The invention provides a microarray and methods for producing a protein microarray. The array comprises multiple nucleic acid molecules immobilized on a substrate, each comprising (i) a protein-binding domain and (ii) a nucleic acid sequence encoding a fusion protein comprising a polypeptide of interest and a DNA-binding protein that binds... Agent: Leydig, Voit & Mayer, Ltd.

20070087364 - In vitro erythroid micronucleus assay for genotoxicity: The present invention is directed to novel assays to measure the genotoxic effects of compounds on erythroid cells in vitro.... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20070087352 - Inhibitors for androgen antagonist refractory prostate cancer: The present invention relates to methods and antagonist compounds for modulating androgen receptor activity. The invention includes a method for identifying molecules that bind to a coactivator binding site of a receptor in the androgen receptor family. Also included is a cocrystal of an androgen receptor ligand binding domain complexed... Agent: Fish & Richardson P.C.

20070087372 - Isolated ductal fluid sample: A sample for diagnosis of breast cancer can be prepared by isolating a ductal fluid sample from one duct of a breast of a patient. The isolated ductal fluid is not mixed with ductal fluid from any other duct of the breast. Generally the target duct is not spontaneously discharging.... Agent: Cytyc Corporation

20070087357 - Lateral flow device with onboard reagents: Devices, methods and kits for conducting an assay to determine the presence or amount of an analyte in a fluid sample. The device includes a sample application element and a flow path matrix that facilitates fluidic flow by capillary action. The sample application element includes a non-absorbent or absorbent carrier... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070087354 - Lentiviral vector-based vaccine: Methods of eliciting humoral responses, methods of immunization, and methods of vaccination using lentiviral vector are disclosed. Additionally, immunogenic compositions and vaccines for West Nile Virus are disclosed.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.

20070087367 - Method and apparatus for combinatorial chemistry: A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be... Agent: Luedeka, Neely & Graham, P.C.

20070087369 - Method for the isolation of rna from biological sources: Methods and kits for isolating RNA are provided that enable rapid RNA preparation from biological sources. In one aspect, RNA is isolated from difficult plant tissues and cells that contain high levels of secondary metabolites, without employing organic extraction or salt precipitation procedures. This method employs novel lysing and binding... Agent: Senniger Powers (sgm)

20070087343 - Method of detecting gene expression and kit and apparatus to be used therein: In an animal embryo or tissue, the following wholeamount treatment is carried out so that gene expression is detected. First, a sample such as an embryo or a tissue is fixed and then pretreated by acetylating an amine with acetic anhydride and eliminating lipids by using xylene. Next, in situ... Agent: Barnes & Thornburg LLP

20070087368 - Method, system and computer software providing a genomic web portal for functional analysis of alternative splice variants: A system for analyzing alternative splice variant sequences is described, comprising an input manager for receiving alternative splice variant sequences that are identified by one or more probe sets, a correlator that correlates functional domains with each of the alternative splice variant sequences and an associater that associates putative functions... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070087360 - Methods and compositions for detecting nucleotides: The present teachings generally relate to methods and materials for the detection of target nucleotides and/or the methylation state of target nucleotides.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070087377 - Methods and compositions for reverse translation: A process is disclosed by which a polynucleotide is directly synthesized from the peptide or protein that it encodes without the need for sequencing (or sequence analysis) of the peptide or protein. Information contained in the sequence of the peptide or protein is directly coupled, by the process of reverse... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20070087375 - Methods and compositions for treating cancer using 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710: The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710 genes in tissues relating to... Agent: Millennium Pharmaceuticals, Inc.

20070087344 - Methods for characterizing signaling pathways and compounds that interact therewith: The genes in a signaling pathway can be identified by over or under-expressing each member of a set of genes to be grouped in signaling pathways and measuring parameters under stimulatory conditions. Genes in a common signaling pathway give similar parameter profiles under such conditions. Moreover, the interactions between signaling... Agent: Bozicevic, Field & Francis LLP

20070087358 - Methods for diagnosing cancer based on dna methylation status in nbl2: The present invention relates to methods for diagnostic or prognostic assay for cancer based on analysis of altered methylation status at specific CpG dinucleotide sequences within the epigenetic marker, NBL2. The methods of the invention comprise determining the methylation status of a subregion of genomic CpG dinucleotide sequences within the... Agent: Jones Day

20070087365 - Methylation markers for diagnosis and treatment of ovarian cancer: Twenty-three markers are provided which are epigenetically silenced in ovarian cancers. The markers can be used diagnostically, prognostically, therapeutically, and for selecting treatments that are well tailored for an individual patient. Restoration of expression of silenced genes can be useful therapeutically, for example, if the silenced gene is a tumor-suppressor... Agent: Banner & Witcoff

20070087353 - Microarray biochemical reaction device: The microarray biochemical reaction device of this invention integrates microfluidic trenches with a microarray to form a serpentine microchannel passing through all DNA probes provided in the microarray. A sample solution is introduced into the microchannel and scrambled into discrete plugs to induce droplet mixing. The discrete plugs are then... Agent: Bacon & Thomas, PLLC

20070087370 - Microarray probe tm matching by selective destabilization: Methods and systems for designing oligonucleotide probes for use in microarray applications are provided herein. The described methods use duplex melting temperature (Tm) matching to destabilize the hybridization oligonucleotide probes to non-target sequences as compared to a target nucleotide sequence. Nucleic acid arrays containing probes selected by the described methods... Agent: Agilent Technologies Inc.

20070087373 - Optimization of immunomodulatory properties of genetic vaccines: This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.... Agent: Bingham, Mccutchen LLP

20070087374 - Optimization of immunomodulatory properties of genetic vaccines: This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.... Agent: Bingham, Mccutchen LLP

20070087351 - Orotate transporter encoding maker genes: A recombinant marker gene encoding an orotate transporter polypeptide comprising an amino acid sequence at least 60% identical to SEQ ID NO: 2, a polynucleotide construct comprising at least one copy of the recombinant marker gene, a cell comprising at least one exogenous copy of the marker gene, and a... Agent: Novozymes North America, Inc.

20070087346 - Orthogonal gene switches: The present invention relates to an orthogonal gene switch for regulating the expression of a desired gene. The gene switch comprises a chimeric transcription factor that does not respond to endogenous ligands, and a ligand that is capable of activating the chimeric transcription factor but not endogenous transcription factors. The... Agent: Merck And Co., Inc

20070087362 - Polony fluorescent in situ sequencing beads: Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.... Agent: Banner & Witcoff, Ltd.

20070087378 - Polynucleotide and polypeptide fat metabolism regulators and uses thereof: In general, this invention relates to nucleic acid and amino acid sequences involved in fat metabolism regulation and the use of these sequences as targets for the diagnosis, treatment, and prevention of obesity and obesity-related diseases. In addition, the invention relates to screening methods for identifying modulators of body fat... Agent: Clark & Elbing LLP

20070087342 - Secreted proteins: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.... Agent: Foley And Lardner LLP Suite 500

20070087361 - Solid support assay systems and methods utilizing non-standard bases: Solid support assays using non-standard bases are described. A capture oligonucleotide comprising a molecular recognition sequence is attached to a solid support and hybridized with a target. In some instances, the molecular recognition sequence includes one or more non-standard bases and hybridizes to a complementary tagging sequence of the target... Agent: Eragen Biosciences, Inc. C/o Foley & Lardner LLP

20070087376 - Splice variants of pre-mrna transcripts as biomarkers in idiopathic neurodegenerative diseases: The present invention discloses a method to discover biomarkers indicative of an idiopathic neurodegenerative disease in a mammalian subject and biomarkers indicative of an idiopathic neurodegenerative disease in the mammalian subject. The biomarker comprises a splice variant mRNA of a precursor-messenger RNA (pre-mRNA) transcript of a gene in the mammalian... Agent: Everest Intellectual Property Law Group

20070087348 - System and method for carrying out multiple binding reactions in an array format: A method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method comprises adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at... Agent: Nath & Associates

20070087363 - Therapeutic methods, compounds and compositions: The invention provides methods of treating, preventing, delaying the onset, slowing the progression, or reversing the symptoms of Alzheimer's disease and other neurodegenerative diseases characterized by the accumulation of amyloid plaques comprising the Aβ42 peptide. The invention also provides compounds that reduce the production or secretion of the Aβ42-peptide by... Agent: Myriad Genetics Inc. Intellecutal Property Department

20070087350 - Use of a mutation in the braf gene for the determination of the malignancy of melanoma cells: The invention relates to the use of oligonucleotide probes comprising exon 15 of the BRAF gene or a part thereof comprising codon 599 for the detection of the malignancy of melanoma cells.... Agent: O'melveny & Myers

20070087379 - Ys68 gene involved in primitive hematopoiesis: A novel gene, dubbed “YS68”, involved in primitive hematopoiesis was successfully isolated from cDNA derived from mouse yolk sacs. In addition, a human gene corresponding to this gene was successfully isolated. Expression characteristics of these genes suggested their involvement in primitive hematopoiesis. The proteins of this invention and genes encoding... Agent: Fish & Richardson PC

20070087371 - Zinc finger domains and methods of identifying same: Disclosed is an in vivo selection method for identifying zinc finger domains that recognize any given target site. Also disclosed are the amino acid sequences of zinc finger domains that recognize particular sites.... Agent: Fish & Richardson PC

20070087389 - Control system using immune network and control method: To provide a new method for autonomously controlling the behavior of a control target device based on a stimulating action and a suppressing action among antibodies in an immune network, an operating unit 3 calculates an antibody concentration ai(t) serving as an index for selecting an antibody module ABi, while... Agent: Mcginn Intellectual Property Law Group, PLLC

20070087384 - Cynomolgus monkey dickkope-4, nucleotides encoding same, and uses thereof: The cynomolgus monkey Dickkopf-4 (cDkk-4) protein, isolated nucleic acid molecules which encode the cDkk-4 protein, and recombinant vectors and hosts comprising DNA encoding the cDkk-4 protein are disclosed. Also disclosed are methods for identifying analytes which interfere with the interaction between the cDkk-4 protein and a homologous or heterologous Dkk... Agent: Merck And Co., Inc

20070087386 - Diagnosis method of endometriosis by detecting biochemical markers and usage of these biochemical markers: The present invention relates to a non-invasive diagnosis method of endometriosis by detecting biochemical marker in serum or peritoneal fluid, in particular alpha 1-antitrypsin, fragments of alpha 1-antitrypsin, or a combination of both. The diagnosis of endometriosis is performed with observing in serum specimens of a patient the concentration and... Agent: Schmeiser, Olsen & Watts

20070087388 - G protein coupled receptor: The invention provides nucleic acid encoding a G protein coupled receptor (adenine binding GPCR) with specificity for adenine, isolated adenine binding GPCR, assay and treatment methods utilising the same.... Agent: Foley And Lardner LLP Suite 500

20070087383 - Immunoassay: The invention provides a method for detecting a hapten in a sample comprising the steps of: a) providing a sample potentially containing the hapten; b) providing a pre-determined amount of a first moiety, said first moiety being bound to a signaller and separated therefrom by a first linker, which first... Agent: Jacobson Holman PLLC

20070087387 - Method for the early detection of renal disease using proteomics: A method for the detection of an early biomarker for assessing a change in renal status in a mammalian subject following a renal event. The method typically includes the steps of (a) providing a body fluid sample obtained from a mammalian subject; (b) analyzing the molecular weight of the proteins... Agent: Hasse & Nesbitt LLC

20070087380 - Method of detecting auto-antibodies from patients suffering from rheumatoid arthritis, a peptide and an assay kit: The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9,... Agent: Morrison & Foerster LLP

20070087381 - Methods for constructing scdb libraries: Bispecific diabody libraries can be constructed from scFv libraries efficiently and without troublesome procedures by a single treatment, placing restriction enzyme sites appropriately for antigen-encoding regions.... Agent: Fish & Richardson PC

20070087382 - Molecule array and method for producing the same: The invention relates to assemblies for bonding molecules comprising bondable functional groups, which are present on a solid supporting material as individual molecular functional groups or multiple identical functional groups. Said assemblies are characterised in that the density of the individual functional groups or multiple functional groups on the solid... Agent: Fulbright & Jaworski L.L.P.

20070087385 - Spherical and magnetical silicagel carriers having an increase surface for purifying nucleic acids: The invention relates to spherical and magnetic silicagel particles which are provided with an increased surface by incorporating SiO2 colloids and produced by a method for inverse dispersion cross-linking of silica sols. The addition of certain metallic oxides to said silica sols and a subsequent tempering make it possible to... Agent: Davidson, Davidson & Kappel, LLC

20070087390 - Opiate, cannabinoid, and estrogen receptors: The present invention relates generally to mu3 opiate receptors, cannabinoid receptors, and estrogen surface receptors (ESRs). Specifically, the invention provides methods and materials for identifying mu3 opiate receptor agonists and antagonists, cannabinoid receptor agonists and antagonists, and ESR agonists and antagonists. In addition, the invention provides an isolated nucleic acid... Agent: Fish & Richardson P.C.

20070087391 - Optoelectronic sensor: A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070087394 - Epidermal growth factor receptor gene copy number: Methods of predicting whether an anti-epidermal growth factor receptor (“EGFr”)-specific binding agent treatment will be efficacious in treating cancer, and methods of treating patients with anti-EGFr-specific binding agents, are provided.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070087392 - Method for diagnosing head and neck squamous cell carcinoma: Disclosed are protein biomarkers and their use in diagnosing head and neck squamous cell carcinoma (HNSCC) or to make a negative diagnosis in patients. Also disclosed are kits for the diagnosis of HNSCC that detect the protein biomarkers of the invention, as well as methods using a plurality of classifiers... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070087393 - Quantitative zap-70 assay: An quantitative ZAP-70 assay is provided, with ZAP-70+ and ZAP-70− controls, normal human blood controls, an improved antibody with better signal to noise ratio, and using the median MEFL that is calibrated using a standard curve.... Agent: Tamsen Valoir, Ph.d. Baker & Mckenzie LLP

20070087395 - Method for detecting pathogenic organisms in fecal and salivary specimens and in biopsy material: The invention relates to a method for detecting pathogenic organisms, in particular Helicobacter pylori and H. heilmanii, in fecal, salivary and secretory samples by means of a double-antibody sandwich assay. The inventive method is characterized by dissolving or dispersing the sample having the pathogen antigen in a buffer solution and... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20070087396 - Method of tacrolimus extraction and quantification using aqueous detergents: The present invention relates to a method of extracting tacrolimus in a test blood sample to use in a tacrolimus quantification assay. The method of the present invention extracts tacrolimus in non-precipitating, non-denaturing aqueous environment, avoiding cumbersome manual pretreatment procedures or the use of organic solvents. The method of the... Agent: Robert Deberardine Abbott Laboratories

20070087398 - Inactivated enzyme variants and associated process and reagent system: The present invention relates to oxidoreductase apoenzyme variants which are enzymaticaily inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors containing such DNA sequences and the use of these oxidoreductase apoenzyme variants in diagnostic applications.... Agent: Barnes & Thornburg LLP

20070087397 - System and method of processing a current sample for calculating a glucose concentration: A system and method of processing a test current for an analyte measurement in a fluid using a test strip and a test meter are disclosed. The method comprises sampling the test current at a pre-determined sampling rate to acquire a plurality of A/D conversions. The method also comprises filtering... Agent: Kagan Binder, PLLC

20070087400 - Covalent tethering of functional groups to proteins and substrates therefor: A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrolase and the substrate and has at least two... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20070087399 - Lactate biosensing strip and method for manufacture thereof: The present invention provides a lactate biosensing strip comprising a working electrode and a reference electrode, the said two electrodes being deposited on an electrically insulated base support, the working electrode being formed by immobilizing an enzyme lactate oxidase and an electro mediator on an inorganic graphite matrix and the... Agent: Nixon & Vanderhye, PC

20070087401 - Analysis of metabolic activity in cells using extracellular flux rate measurements: Disclosed are methods for non-destructively measuring in vitro the effect on cellular metabolism of the addition to animal cells in culture of a soluble molecule potentially capable of perturbing the biological state of the cells, such as a drug or drug candidate, a toxin, a ligand known or suspected to... Agent: Goodwin Procter LLP Patent Administrator

20070087402 - Oxygen-assisted fermentation process: A fermentation process uses substantially pure oxygen. The oxygen is the only reactive gas which is injected into a fermentation vessel. The oxygen is moved through the vessel solely by its own pressure. The process can be used with both mechanically-agitated and air-lifted fermenters. The mechanically-agitated fermenter includes an analyzer... Agent: Air Liquide

20070087403 - Optimised micro-organism strains for nadph-consuming biosynthetic pathways: The invention relates to optimised micro-organism strains for the biotransformation production of molecules having NADPH-consuming biosynthetic pathways. The inventive strains can be used in NADPH-consuming biotransformation methods. Said strains are characterised in that one or more NADPH-oxidising activities are limited.... Agent: Dorsey & Whitney LLP Intellectual Property Department

20070087404 - Poly-beta-peptides from functionalized beta-lactam monomers and antibacterial compositions containing same: Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide,... Agent: Dewitt Ross & Stevens S.c. Wisconsin Alumni Research Foundation

20070087409 - Angiotensin peptide-carrier conjugates and uses thereof: The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, particularly a virus-like particle (VLP). The invention also provides methods of producing such conjugates, and immunotherapeutic uses of... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070087405 - Expression system for producing collagen: A DNA molecule consisting of the nucleotide sequence of SEQ ID NO: 1, which encodes a collagenous (COL1) domain and a C-terminal noncollagenous (NC1) domain of type XXI collagen. Expression systems and methods for the expression of the DNA molecule are also provided.... Agent: Birch Stewart Kolasch & Birch

20070087407 - Hepatitis c receptor protein cd81: The present invention relates to the use of CD81 protein and polynucleic acid in the therapy and diagnosis of hepatitis C and pharmaceutical compositions, animal models and diagnostic kits for such purposes.... Agent: Novartis Vaccines And Diagnostics Inc.

20070087406 - Isoforms of receptor for advanced glycation end products (rage) and methods of identifying and using same: Isoforms of RAGE and pharmaceutical compositions containing RAGE isoforms are provided. Methods for identifying and preparing RAGE isoforms are provided. Also provided are methods of treatment with the RAGE isoforms.... Agent: Fish & Richardson, PC

20070087412 - Metalloprotease-disintegrin adam23 (svph3-17): The invention is directed to purified and isolated novel SVPH3-13 or SVPH3-17 polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.... Agent: Immunex Corporation Law Department

20070087413 - Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins: Methods and compositions for producing secreted soluble receptors and biologically active polypeptides in trimeric forms are disclosed. The process involves fusing the DNA template encoding a soluble receptor with a ligand binding domain or biologically active polypeptide to a DNA sequence encoding a C-propeptide of collagen, which is capable of... Agent: Lambert & Associates, P.l.l.c.

20070087410 - Microbially-expressed thermotolerant phytase for animal feed: The invention provides methods for making and using thermotolerant phytases, e.g., a method of using a thermotolerant phytase in feed and food processing and feed or food products comprising a thermotolerant phytase.... Agent: Syngenta Biotechnology, Inc. Patent Department

20070087411 - Monomeric self-associating fusion polypeptides and therapeutic uses thereof: Monomeric fusion polypeptides comprising R1-M-L-M, wherein R1 is a target ligand-binding domain, M is a multimerizing component, and L is a linker capable of allowing one M component to interact with the other M component to form a self-associating monomer, optionally comprising a second target ligand-binding domain R2. Preferred target... Agent: Regeneron Pharmaceuticals, Inc

20070087408 - Regulation of toll-like receptors on stem cells: The discovery of Toll-like receptors (TLRs) on the surface of hematopoietic cells provides new methods for the stimulation and differentiation of various classes of progenitor cells. TLR2 and TLR4 agonists (natural ligands, mimetics, antibodies) are particularly useful in these methods. The cells can be isolated and used for various purpose... Agent: Fulbright & Jaworski L.L.P.

20070087414 - Uses of human zven proteins and polynucleotides: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods for treating intestinal motility disorders and improving gastrointestinal function with Zven1 and Zven2 polypeptides.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070087416 - Hyaluronan synthase gene and uses thereof: The present invention relates to a recombinantly produced, enzymatically active hyaluronan synthase, wherein the recombinantly produced, enzymatically active hyaluronan synthase is a single protein that is a dual-action catalyst that utilizes UDP-GlcA and UDP-GlcNAc to synthesize HA. The recombinantly produced, enzymatically active hyaluronan synthase may be produced from a hyaluronan... Agent: Dunlap, Codding & Rogers P.C.

20070087415 - Methods for producing modified microcrystalline chitosan and uses therefor: Disclosed are methods of producing modified microcrystalline chitosan. Chitosan in aqueous solution is degraded enzymatically, hydrolytically or oxidatively. The chitosan solution is then alkalized with agitation using aqueous hydroxides and/or their salts to attain a pH not lower than 7.0. The precipitated modified microcrystalline chitosan is highly pure and may... Agent: Dykema Gossett PLLC

20070087417 - Multiplex polynucleotide synthesis: The invention provides a method of convergently synthesizing mixtures of either single stranded or double stranded polynucleotides. In one aspect, oligonucleotides that form components of such polynucleotides are synthesized on one or more microarrays, or other large-scale parallel solid phase synthesis platforms, after which they are amplified directly, or are... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070087418 - Immobilization of enzymes: The present invention relates to the immobilization of enzymes by adsorbing enzymes, a polyfunctional amine and a cross-linking agent onto a particulate porous carrier in a mixer apparatus or in a fluid bed apparatus.... Agent: Novozymes North America, Inc.

20070087419 - Method of producing biotin: The present invention relates to the production process of biotin by fermentation using genetically engineered microorganisms, including Escherichia coli and Pseudomonas mutabilis, and DNA sequences and vectors to be used in such process.... Agent: Locke Liddell & Sapp LLP Attn: Docketing Dept.

20070087420 - Mortierella alpina c16/18 fatty acid elongase: The present invention relates to a fungal C16/18 fatty acid elongase that is able to catalyze the conversion of palmitate (16:0) to stearic acid (18:0). Specifically, the nucleotide sequence of a Mortierella alpina C16/18 fatty acid elongase is provided (designated as “ELO3”). Methods of increasing microbial oil production, increasing carbon... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070087421 - Transformant and process for producing polyester using the same: A gene expression cassette comprising an Aeromonas caviae-origin polyhydroxyalkanoic acid (PHA) synthase gene having a mutation introduced thereinto and a promoter and a terminator acting in a yeast; a transformant constructed by transferring the above gene expression cassette into a yeast; and a process for producing a polyester using the... Agent: Kenyon & Kenyon LLP

20070087422 - Process for the preparation of (-) modafinil: An enzymatic process for the preparation of intermediates useful in the synthesis of (−) modafinil.... Agent: Young & Thompson

20070087423 - Coryneform bacterium transformant and process for producing dicarboxylic acids using the same: The present invention provides an aerobic coryneform bacterium transformant in which a lactate dehydrogenase gene is disrupted, and a pyruvate carboxylase gene is recombined so as to be highly expressed by a genetic engineering method. The aerobic coryneform bacterium transformant of the present invention can produce dicarboxylic acids from saccharides... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070087424 - Methods and materials for the production of shikimic acid: Novel enzymes and novel enzymatic pathways for the pyruvate-based synthesis of shikimate or at least one intermediate thereto or derivative thereof, nucleic acids encoding the enzymes, cells transformed therewith, and kits containing said enzymes, cells, or nucleic acid. A KDPGal aldolase is used to perform condensation of pyruvate with D-erythrose... Agent: Harness, Dickey & Pierce, P.L.C

20070087425 - Methods of producing prenyl alcohols: A method of producing a prenyl alcohol, comprising creating a recombinant by transferring into a host a recombinant DNA for expression or a DNA for genomic integration each comprising a prenyl diphosphate synthase gene or a mutant thereof, culturing the resultant recombinant, and recovering the prenyl alcohol from the resultant... Agent: John C. Altmiller Kenyon & Kenyon

20070087426 - Novel transferase and amylase, process for producing the enzymes, use thereof, and gene coding for the same: The invention provides a novel transferase that acts on a saccharide, as a substrate, composed of at least three sugar units wherein at least three glucose residues on the reducing end are linked α-1,4 so as to transfer the α-1,4 lingages to a α-1, α-1 linkages; a process for producing... Agent: Foley And Lardner LLP Suite 500

20070087427 - Crystal structure of a deacetylase and inhibitors thereof: The present invention provides three-dimensional structural information from the hyperthermophilic bacterium Aquifex aeolicus which is a histone deacetylase-like protein (HDLP). HDLP shares 35.2% amino acid sequence identity with human histone deacetylase (HDAC1). The present invention further provides three-dimensional structural information of HDLP bound by inhibitor molecules. The three-dimensional structural information... Agent: Michelle A. Klein C/o Mintz Levin, Cohen, Ferris, Et Al.

20070087428 - Apparatus for producing tissue arrays: An apparatus for producing a tissue array is described. At least one receiver block (1), and at least one donor block (2) that comprises tissue (3) to be investigated, are provided, a first hollow needle (4) for creating a cavity in the receiver block (1), and a second hollow needle... Agent: Hodgson Russ LLP

20070087431 - Cassette for sample preparation: A cassette for preparing a sample is disclosed herein. The cassette includes a housing, which encloses the structures and the processes used to prepare the sample.... Agent: Stephen M. De Klerk Blakely, Sokoloff, Taylor & Zafman LLP

20070087430 - Method and apparatus for detection of biological organisms using raman scattering: A system for the detection of compounds, including a target biological organism or component from a sample, using one or more reactant that will bind to the biological organism or compound forming a Raman active product, concentrating the Raman active product, and detecting the Raman active product using Raman light... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070087429 - Reaction disk and separation cell for automatic analyzer: s

20070087433 - Metabolically activated recombinant viral vectors and methods for their preparation and use: Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction and use, are provided. The vectors have a structure, or are capable of rapidly adopting a structure, which involves intrastrand base pairing of at least one... Agent: Morrison & Foerster LLP

20070087432 - Smallpox vaccine series 77: Herpes is treated by administering a smallpox vaccination and by repeatedly administering the vaccination after waiting a scab, formed after a blister at the vaccination site, falls off, with the treatment being completed when the blister and scab fail to form.... Agent: John Ames Harrington

20070087434 - Antiviral artificial cell: An antiviral artificial cell includes: an artificial cytoskeleton, an artificial cytomembrane wrapping the artificial cytoskeleton, and a nanoparticle rotatably retained on the artificial cytomembrane and having a surface for capturing a virus.... Agent: Amin, Turocy & Calvin, LLP

20070087435 - Multicellular compositions of pluripotent human embryonic stem cells and cancer cells: Methods are provided for producing novel multicellular compositions comprising cancer cells together with pluripotent human stem cells, which are capable of proliferating and differentiating into various normal cell lines and tissue structures. These novel multicellular compositions are useful for investigating the properties of cancer cells in a normal human tissue... Agent: Heslin Rothenberg Farley & Mesiti PC

20070087436 - Microinjection method and device: An object of the present invention is to provide a method for introducing a physiologically active substance such as a gene into a cell, which introduces a physiologically active substance such as any given gene into any given cell in a view under a microscope, while significantly reducing invasiveness to... Agent: Scully, Scott, Murphy & Presser, P.C.

20070087437 - Methods for rejuvenating cells in vitro and in vivo: The present invention provides methods for rejuvenating cells, tissues and the whole body. Also provided are rejuvenating buffers and agents as well as kits for rejuvenating cells. Also provided are methods for dedifferentiating somatic cells and differentiating the cells into other cell types.... Agent: The Luther Law Firm

20070087438 - Methods for conditioning plant somatic embryos: The present invention provides methods for conditioning plant somatic embryos. The methods include the step of exposing the somatic embryos to a gas stream having a selected moisture content for a period of time sufficient to change the moisture content of the somatic embryo to a desired moisture content, wherein... Agent: Weyerhaeuser Company Intellectual Property Dept., Ch 1j27

20070082327 - Cellular phenotype: Phenotypes and the cells that exhibit those phenotypes are described. The phenotype may be established as a “snapshot” of the cells at a particular time or it may be established as a variation in features over time, or as some combination of these “static” and “dynamic” characterizations. The phenotype may... Agent: Beyer Weaver LLP

20070082329 - Infertility assessment and treatment system: A method for assessing fertility for a couple that includes obtaining semen analysis results from a male member of the couple, obtaining fertility survey responses from at least a female member of the couple, determining an initial location in a diagnostic matrix using the semen analysis results and the fertility... Agent: Osha Liang L.L.P.

20070082328 - Rotatable time varying electromagnetic force bioreactor and method of using the same: A rotatable time varying electromagnetic force bioreactor comprising a culture chamber having an interior portion that removably receives a cell mixture and an exterior portion with an electrically conductive coil wrapped around the exterior portion, a motor for rotating the culture chamber, and a time varying electromagnetic force source operatively... Agent: Ladas & Parry LLP

20070082331 - Chemical processing cartridge and method of using same: A cartridge capable of making effective use of a sample is provided. A blood sample is injected into a well via an injection path by use of a syringe, and so forth. A roller, in a state as kept pressed into contact with the cartridge, is rotated rightward, whereupon an... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20070082330 - Compounds displayed on icosahedral phage and methods of using same: Icosahedral phage and collections thereof that display various compounds are provided. In some instances, the icosahedral phage include nucleic acid tags that serve to record a characteristic of the compound or compounds that are attached to the phage. A number of different methods for using the icosahedral phage to screen... Agent: Townsend And Townsend And Crew, LLP

20070082354 - method for isolating rna: A method for isolating RNA from RNA containing samples wherein the RNA containing sample is treated with at least one DNase and/or another enzyme like proteases or collagenases for purification of RNA in presence of a complex of ribonucleosides and the oxovanadyl ion which is capable of inhibiting RNases present... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070082350 - Assay and method for diagnosing and treating alzheimer's disease: I Methods and kits for diagnosing Alzheimer's disease and/or incipient Alzheimer's disease are disclosed. The methods and kits of the invention utilize a set of genes and their encoded proteins that are shown to be correlated with incipient Alzheimer's disease.... Agent: Mcdermott Will & Emery LLP

20070082338 - Cgh array quality assessment: Methods, systems and computer readable media for characterizing quality of CGH arrays, including generating at least one metric for a CGH array that characterizes a property of the CGH array; repeating generation of the at least one metric for at least one additional CGH array; and comparing each metric across... Agent: Agilent Technologies Inc.

20070082344 - Discrimination method of target base in dna, and allele specific primer used in the method of the same: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is A, while a base adjacent with one... Agent: Mcdermott Will & Emery LLP

20070082348 - Discrimination method of target base in dna, and allele specific primer used in the method of the same: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is A, while a base adjacent with one... Agent: Mcdermott Will & Emery LLP

20070082361 - Dna and proteins or peptides specific of bacteria of the neisseria meningitidis species, methods for obtaining them and biological applications thereof: The DNA of the invention are characterised in that they concern the whole or part of genes, with their reading frame, to be found in Neisseria meningitidis, but not in Neisseria gonorrhoeae, or in Neisseria lactamica except the genes involved in the biosynthesis of the polysaccharide capsule, frp A, frp... Agent: Nixon & Vanderhye, PC

20070082347 - Gene variants and use thereof: Variants in TLK1, WARS2, ARTS2, MSR, AKAP9, DNAJD1, GOLPH4, RABEP1, TAP2, NARG2, DDX58, CD39, FKBP1a, SRI, XRRA1, IRF5 and AMFR genes are disclosed which are useful as biomarkers for predicting the TLK1, WARS2, ARTS2, MSR, AKAP9, DNAJD1, GOLPH4, RABEP1, TAP2, NARG2, DDX58, CD39, FKBP1a, SRI, XRRA1, IRF5 or AMFR gene... Agent: Myriad Genetics Inc. Intellecutal Property Department

20070082353 - Genetic marker selection program for genetic diagnosis, apparatus and system for executing the same, and genetic diagnosis system: There is provided a marker selection program for selecting a marker for use in genetic diagnosis. In the program, analysis is carried out by using at least two specimen databases which respectively store data of specimens belonging different populations. By carrying out analysis without integrating all specimen data into single... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070082346 - Homogeneous detection method: The invention relates to methods for the quantitative or qualitative detection of an analyte in an assay and adequate reagents therefor, particularly a homogeneous binding test. According to the invention, an analyte-specific binding partner R1 comprises more than one specific binding point for a specific binding partner X that is... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070082341 - Human phospholipases: The invention provides human lipid metabolism enzymes (LME) and polynucleotides which identify and encode LME. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LME.... Agent: Foley And Lardner LLP Suite 500

20070082360 - Magnetic pigment: Magnetic particles with an outer glass surface being essentially poreless or having pores of a diameter of less then 10 nm as well as ferromagnetic particles with a glass surface are preferentially useful for the isolation of biological material from samples. They provide a quick and reliable purification.... Agent: Roche Molecular Systems Inc Patent Law Department

20070082355 - Method for polymerase chain reactions with use of a dna polymerase with proofreading properties: The present invention concerns a method for a polymerase chain reaction, in which a template nucleic acid, at least one primer, deoxyribonucleoside triphosphates as well as a DNA polymerase with proofreading activity are used. In addition, according to this invention, at least one target substrate is added to the polymerase... Agent: Seed Intellectual Property Law Group PLLC

20070082343 - Method for the control of segment-wise enzymatic duplication of nucleic acids via incomplete complementary strands: The invention relates to a new method for the control of enzymatic duplication of nucleic acids by the section via incomplete complementary strands. Fields of application of the invention are research, medical practice, gene-based analytics of biotechnological, agricultural and foodstuff products as well as criminology.... Agent: Buchanan Ingersoll & Rooney PC

20070082357 - Method of estimating the risk of expression of adverse drug reaction caused by the administration of a compound, which is either metabolized per se by ugt1a1 enzyme or whose metabolic intermediate is metabolized by the enzyme: A method of estimating a risk of the expression of an adverse drug reaction caused by the administration of irinotecan; and a method of reducing the adverse drug reaction caused by the administration of irinotecan. A polymorphism on the basis of a difference in the repeating numbers of TA repetitive... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20070082339 - Methods and compositions for screening for hdac inhibitory activity: The invention relates to the use of gene and protein expression levels as a marker for HDAC inhibition. Also disclosed are in vivo and in vitro methods for screening a compound for HDAC inhibitory activity, as well as methods for monitoring the therapeutic efficacy of an HDAC inhibitor in a... Agent: Novartis Corporate Intellectual Property

20070082335 - Methods and compositions for treatment of viral infections based on tsg101-vps28 interaction: The invention provides methods and compositions based on the interaction of TSG101 and VPS28 proteins for treatment of viral infections, including HIV infections. The invention also provides TSG101-VPS28 based methods and compositions for evaluation and screening of drugs which can be used for treating viral infections.... Agent: Merchant & Gould PC

20070082359 - Methods for detecting compounds that interfere with protein aggregation utilizing an in vitro fluorescence-based assay: Methods of identifying a compound that inhibit, enhance and/or misdirect assembly of a viral capsid include providing fluorescently-labeled capsid polypeptides labeled with a fluorescent dye that changes fluorescence at high concentration, wherein assembly of the capsid polypeptides into the viral capsid results in juxtaposition of at least one of the... Agent: Dunlap, Codding & Rogers P.C.

20070082336 - Methods for protein labeling based on acyl carrier protein: A method for labeling acyl carrier protein (ACP) fusion proteins with a wide variety of different labels is disclosed. The method relies on the transfer of a label from a coenzyme A type substrate to an ACP fusion protein using a holo-acyl carrier protein synthase (ACPS) or a homologue thereof.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070082356 - Methods of evaluating transplant rejection: The invention relates to methods of evaluating transplant rejection in a host comprising determining a heightened magnitude of gene expression of genes in rejection-associated gene clusters. The disclosed gene clusters include genes that are substantially co-expressed with cytotoxic lymphocyte pro-apoptotic genes, cytoprotective genes and several other cytokine and immune cell... Agent: Fish & Richardson PC

20070082337 - Methods of identifying putative gene products by interspecies sequence comparison and biomolecular sequences uncovered thereby: A method of identifying alternatively spliced exons is provided. The method comprising, scoring each of a plurality of exon sequences derived from genes of a species according to at least one sequence parameter, wherein exon sequences of the plurality of exon sequences scoring above a predetermined threshold represent alternatively spliced... Agent: Martin D. Moynihan Prtsi, Inc.

20070082352 - Microscopy tip: Disclosed is a tip for use in atomic force microscopy. The tip includes a substrate and a three-dimensional, double-stranded nucleic acid structure attached thereto. The nucleic acid structure may have a single-stranded nucleic acid attached thereto, such as an aptamer sequence. In use, the tip having the nucleic acid structure... Agent: Intellectual Property Department Dewitt Ross & Stevens, S.c.

20070082332 - Molecular cardiotoxicology modeling: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of... Agent: Morgan Lewis & Bockius LLP

20070082342 - Near-patient module for analyte detection system: In certain embodiments, an apparatus for analyzing the composition of bodily fluid includes a first fluid passageway having a patient end which is configured to provide fluid communication with a bodily fluid within a patient. The apparatus further includes at least one pump coupled to the first fluid passageway. The... Agent: Knobbe Martens Olson & Bear LLP

20070082334 - Nucleotide and protein sequence of mammastatin and methods of use: A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and... Agent: Medlen & Carroll, LLP

20070082349 - Photocrosslinking probes and uses of the same: A method of detecting a target nucleic acid is disclosed, the method comprising detecting the presence of a fluorescent covalent crosslinked product from non-fluorescent precursors. The fluorescent covalent crosslinked product comprises a novel fluorophore structure. Also described are methods of synthesizing probe molecules that can form fluorescent covalent crosslinked products... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20070082351 - Reagents, methods and kits for classification of fungi and direction of anti-fungal therapy: Provided herein are methods, kits and compositions to classify fungi. Methods are provided for classification of fungi according to established phenotypes, for example, antimicrobial susceptibility profiles. More specifically, the invention provides methods for the use of PNA probes in diagnostic applications, which will aid in the direction of appropriate therapy... Agent: Edwards & Angell, LLP

20070082345 - Secretory protein or membrane protein: Novel human secretory proteins or membrane proteins, and full length cDNAs encoding the proteins are provided. 173 kinds of novel proteins and polynucleotides encoding these proteins have been isolated. The proteins of the present invention are useful as candidates for medicines or as target molecules for developing medicines. The polynucleotides... Agent: Foley And Lardner LLP Suite 500

20070082340 - Sequences for detection and identification of methicillin-resistant staphylococcus aureus (mrsa): Described herein are novel SCCmec right extremity junction (MREJ) sequences for the detection and/or identification of methicillin-resistant Staphylococcus aureus (MRSA). Disclosed are methods and compositions based on DNA sequences for the specific detection of MREJ sequences designated types xi, xii, xiii, xiv, xv, xvi, xvii, xviii, xix, and xx for... Agent: Knobbe Martens Olson & Bear LLP

20070082358 - Sequencing by synthesis based ordered restriction mapping: The present invention is directed to a method for de novo assembly of genomic sequence information comprising the combination optical whole genome restriction mapping and ultra high throughput pyrosequencing.... Agent: Roche Diagnostics Operations Inc.

20070082333 - Thermophilic dna polymerases from thermoactinomyces vulgaris: The present invention provides compositions comprising thermostable DNA polymerases derived from hyperthermophilic eubacteria. In particular, the present invention comprises thermostable DNA polymerases from the hyperthermophilic eubacterial species Thermoactinomyces vulgaris. The present invention also provides methods for utilizing naturally-occurring and non-naturally-occurring forms of T. vulgaris DNA polymerase in sequencing, reverse transcription,... Agent: Medlen & Carroll LLP

20070082364 - Antibody and use thereof: The antibody of the present invention, which specifically reacts with a partial peptide at the N-terminal region or the C-terminal region of NPW, which enables to quantify NPW with highly sensitivity and specifically. Moreover, this antibody is useful as an agent for preventing/treating infertility, renal edema, digestive ulcer, gastric hyperacidity,... Agent: Edwards & Angell, LLP

20070082362 - Modified soluble t cell receptor: The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all or part of a TCR $g(a) chain, except the transmembrane domain thereof, and (ii) all or part of a TCR $g(b) chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain... Agent: Banner & Witcoff

20070082365 - Protein scaffolds for antibody mimics and other binding proteins: Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.... Agent: Patent Group Ropes & Gray LLP

20070082363 - Secreted polypeptide species reduced cardiovascular disorders: The invention discloses human secreted polypeptides that circulate at a decreased level in the plasma of patients with cardiovascular disorders. The invention also provides methods of using compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for these polypeptides, for diagnosis, prognosis, and treatment of cardiovascular disorders.... Agent: Novartis Corporate Intellectual Property

20070082366 - Alzheimer's disease-specific alterations of the erk1/erk2 phosphorylation ratio: The present invention is directed to methods of diagnosing Alzheimer's disease in a subject by detecting alterations in the ratio of specific phosphorylated MAP kinase proteins in cells after stimulation with a protein kinase C activator. The Alzheimer's disease-specific molecular biomarkers disclosed herein are useful for the diagnosis of Alzheimer's... Agent: Milbank, Tweed, Hadley & Mccloy LLP

20070082368 - Human cell clones useful for functional analyses of the biological activity of an endogeneous urotensin ii receptor and uses thereof: Human cell clones with increased specific binding to urotensin II have been sub-cloned from SJRH30 (ATCC® Number: CRL-2061™). These cell clones have been used for functional analyses of the biological activity of an endogeneous urotensin II receptor, as well as for identifying compounds that regulate the biological activity of an... Agent: Philip S. Johnson Johnson & Johnson

20070082369 - Method for production and use of mite group 1 proteins: The present invention includes a method to produce a recombinant mite Group 1 protein in a methyltrophic yeast or an Escherichia coli microorganism. The present invention also relates to a recombinant mite Group 1 protein obtained by such a method, such a recombinant protein being able to selectively bind IgE... Agent: Lahive & Cockfield, LLP

20070082367 - Methods of purifying anti a beta antibodies: The present application provides methods of purifying Aβ binding proteins having a Fc region, for example, anti-Aβ antibodies or antibody fusions, by adsorbing the Aβ binding protein to a Fc binding agent, such as, for example, Protein A or Protein G, followed by a wash with a divalent cation salt... Agent: Lahive & Cockfield, LLP

20070082370 - Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane: A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or... Agent: Townsend & Banta C/o Portfolio Ip

20070082371 - Family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof: An isolated polynucleotide at least 60% homologous to SEQ ID NO: 1, 3, 5 or 18 encoding a SARP polypeptide; vectors comprising a polynucleotide sequence encoding at least 11 consecutive amino acids of αSARP polypeptide; a host cell transformed with an isolated polynucleotide or vector; antibodies specific for SARP and... Agent: Sheridan Ross PC

20070082372 - Membrane system for blood coagulation testing: A system and machine for testing a coagulation process in whole blood and for deriving a result from same.... Agent: Katharine A. Jackson Huebsch Medtronic, Inc.

20070082373 - Processes for regulating blood glucose in a mammal and novel polypeptides useful in nad biosynthesis: The present invention relates to processes for regulating the blood glucose concentration of a mammal. A polypeptide useful in nicotinamide adenine dinucleotide (NAD) biosynthesis is also described.... Agent: Senniger Powers

20070082374 - Method of treating a condition associated with phosphorylation of task-1: This invention provides methods and compositions for treating a condition associated with phosphorylation of TASK-1 in a subject comprising administering to the subject an amount of an agent effective to overcome the phosphorylation dependent loss of TASK-1 function so as to thereby treat the condition. In a specific embodiment of... Agent: Kenyon & Kenyon LLP

20070082376 - Device and method for determining antibiotic susceptibility: The present invention provides a method of determining the antibiotic susceptibility of a microorganism comprising the following steps. First, a culture of the microorganism whose susceptibility is to be determined is admixed with an antibiotic to which susceptibility is to be assayed, and a permeabilizing agent for the microorganism present... Agent: Stinson Morrison Hecker LLP Attn: Patent Group

20070082375 - Method for treating onychomycosis: A novel method for evaluating an effect of an antimicrobial agent which comprises removing the antimicrobial agent remaining in a biological sample or the like to thereby accurately evaluate the effect of the antimicrobial agent without being affected by the remaining antimicrobial agent. A therapeutic agent for onychomycosis which can... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20070082377 - Cytotoxicity assays: Certain embodiments of the invention provide methods and kits for determining cell viability and measuring cytotoxicity.... Agent: Viksnins Harris & Padys Pllp

20070082378 - Convergent synthesis of proteins by kinetically controlled ligation: The present invention concerns methods and compositions for synthesizing a polypeptide using kinetically controlled reactions involving fragments of the polypeptide for a fully convergent process. In more specific embodiments, a ligation involves reacting a first peptide having a protected cysteyl group at its N-terminal and a phenylthioester at its C-terminal... Agent: Fulbright & Jaworski L.L.P.

20070082379 - Novel chimeric polypeptide and use thereof: A chimeric polypeptide comprising a TNF neutralizer domain, an IL-1 receptor antagonist domain, and a dimerization domain, wherein the three domains are operably linked to each other. Within the scope of this invention are (i) nucleic acids encoding the polypeptide; (ii) expression vectors and host cells containing the nucleic acids;... Agent: Fish & Richardson PC

20070082380 - Nucleic acids encoding and methods of producing fusion proteins: The invention provides compositions, methods, and kits for increasing transport of agents across the blood brain barrier while allowing their activity once across the barrier to remain substantially intact. The agents are transported across the blood brain barrier via one or more endogenous receptor-mediated transport systems. In some embodiments the... Agent: Wilson Sonsini Goodrich & Rosati

20070082381 - Polypeptides of alicyclobacillus sp.: The present invention relates to Isolated mature functional polypeptide which is at least 90% identical to and exhibits the same function of a corresponding secreted polypeptide obtainable from the bacterium Alicyclobacillus sp. deposited under accession number DSM 15716 are disclosed.... Agent: Novozymes North America, Inc.

20070082382 - Development of human monoclonal antibodies and uses thereof: This invention provides: a heteromyeloma, other than B6B11, capable of producing a trioma when fused with a human lymphoid cell, wherein the trioma is capable of producing a monoclonal antibody-secreting tetroma when fused with a second, antibody-secreting human lymphoid cell; a trioma fusion partner which does not produce antibody, obtained... Agent: John P. White, Esq. Cooper & Dunham LLP

20070082383 - Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070082384 - Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids: Disclosed is a process for growing the microflora Thraustochytrium, Schizochytrium, and mixtures thereof, which includes the growing of the microflora in fermentation medium containing non-chloride containing sodium salts, in particular sodium sulfate. In a preferred embodiment of the present invention, the process produces microflora having a cell aggregate size useful... Agent: Sheridan Ross PC

20070082385 - Fermentation process: The present invention provides a process of producing a fermentation product including introducing the fermenting organism into the fermentation medium and thereafter adding a carbohydrate generating enzyme after the lag phase of the fermenting organism and then carry out fermentation under conditions suitable for producing the fermentation product in question.... Agent: Novozymes North America, Inc.

20070082386 - Traits in recombinant xylose-growing saccharomyces cerevisiae strains using genome-wide transcription analysis: New xylose-utilizing Saccharomyces cerevisiae strain which can ferment xylose to ethanol. It expresses the gene for A) xylose reducatse (XR) and Xylitol dehydrogenase (XDH) or B) xylose isomerase (XI) and has a) increased transporting capacity with regard to xylose, b) increased conversion capacity of xylulose to xylulose-5P, c) increased activity... Agent: Matthew E. Connors Gauthier & Connors LLP

20070082387 - Method of hydrogen production combining a bioreactor with a nuclear reactor and associated apparatus: The present invention provides a method of hydrogen production, wherein organic feed material is heated with excess or diverted heat from a nuclear reactor, thereby substantially deactivating or killing methanogens within the organic feed material. Hydrogen producing microorganisms contained or added to the organic feed material metabolize the organic feed... Agent: Eckert Seamans Cherin & Mellott

20070082388 - Enhanced mediated dna transfer: A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibornectin fragments. The fibronectin and fibronectin fragments significantly enhance retroviral-mediated gene transfer into the cells, particularly hematopoietic cells including committed progenitors and primitive hematopoietic stem... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20070082389 - Sample homogeniser: An apparatus for comminuting or homogenising biological tissue, comprising a container (1) with an interior bottom (5) comprised of an abrasive surface (6) a cap (10), and a grinder (20) receivable in the interior (2) of the container (1). Wherein the grinder (20) comprises a grinding head (21) and a... Agent: Foley & Lardner LLP

20070082390 - Scaffold carrier cartridge: A scaffold handling system comprising a multi-well carrier including an array of well units wherein, in each well unit, an independent scaffold or tissue slice may be held and a biological experiment may be performed. The carrier may include any number of well units. In operation, the scaffold handling system... Agent: David W. Highet Becton, Dickinson And Company

20070082391 - Modified cea nucleic acid and expression vectors: The present invention relates to a nucleic acid encoding a polypeptide and the use of the nucleic acid or polypeptide in preventing and/or treating cancer. The invention relates to improved vectors for the insertion and expression of foreign genes encoding tumor antigens for use in immunotherapeutic treatment of cancer. One... Agent: Patrick J Halloran Aventis Pasteur Inc

20070082394 - Cell culture media, kits and methods of use: Albumin-supplemented and xenogeneic product-free cell culture media, cell culture media supplements, and cell culture media kits for the support of primary culture of normal non-hematopoietic cells of mesodermal origin suitable for both research and clinical applications.... Agent: John F. Letchford

20070082392 - Modified erythrocytes and uses thereof: The present invention provides modified erythrocytes which comprise viral receptor proteins capable of mediating entry of respective viruses into the modified erythrocytes. The present invention also provides methods of using the modified erythrocytes for the treatment or prevention of viral infections. In one embodiment, the modified erythrocytes of the present... Agent: Nixon Peabody, LLP

20070082393 - Polymer coated nanofibrillar structures and methods for cell maintenance and differentiation: The invention provides cell-adherent polymeric coatings for articles having a nanofibrillar structure. The coatings include a synthetic, non-biodegradable polymer having at least one pendent amine group, wherein the polymer is covalently immobilized on the article via latent reactive groups. The invention also provides methods for the long term culturing of... Agent: Kagan Binder, PLLC

20070082395 - Production of normal human osteoclasts: The present invention provides a method of producing a cell population enriched for osteoclasts in which bone marrow mononuclear cells (BMNC) are cultured in a medium supplemented with growth factors, cytokines, or a combination thereof for at least 7 days to obtain colony-forming units of granulocytes and macrophages (CFU-GM); CFU-GM... Agent: Pearl Cohen Zedek Latzer, LLP

20070082396 - Eleminating myoglobin from blood using iv filter: Prevention of Acute Renal Failure following myoglobinemia in cases of rhabdomyolysis by means of trapping myoglobin released to circulation following striated muscles injury using a temporary intravenous filter, hence prophylaxis of Acute Renal Failure, which commonly follows this situation. It is directed to all cases of rhabdomyolysis especially for “In... Agent: Ali Mokhtar Al Hossary

20070082397 - Ex vivo progenitor and stem cell expansion for use in the treatment of disease of endodermally-derived organs: Methods of ex-vivo expansion of endodermally-derived and non-endodermally-derived progenitor and stem cells, expanded populations of renewable progenitor and stem cells and to their uses in therapeutic applications such as the production of endocrine hormones and the prevention and treatment of liver and pancreatic disease.... Agent: Martin D Moynihan Prtsi Inc

20070082398 - Self-contained cell culture apparatus and method of use: A self-contained cell culture apparatus and method of use in which a cell culture may be stored frozen for an extended period, then thawed, incubated and grown in a closed system without additional processing or added constituents. The apparatus and method readily lend themselves to automated handling and analysis by... Agent: Morrison & Foerster LLP

20070082399 - Compositions and method for stable isotope labelling of biological compounds: The present invention is concerned the labelling of biological compounds with stable isotopes such that the three-dimensional structure of the biological compounds may be analysed by e.g. NMR spectroscopy. The invention employs microorganisms that are grown on mineral media comprising carbon and nitrogen sources that contain stable isotopes to produce... Agent: Sughrue Mion, PLLC

20070082400 - Mature dendritic cell compositions and methods for culturing same: This invention provides methods to prepare and use immunostimulatory cells for enhancing an immune response. The invention provides a method for preparing mature dendritic cells (DCs), comprising the sequential steps of: (a) signaling isolated immature dendritic cells (iDCs) with a first signal comprising an interferon gamma receptor (IFN-γR) agonist and/or... Agent: Elaine Sale, Ph.d. Argos Therapeutics, Inc.

20070077546 - Concentration techniques in chromatographic separation: Apparatus and methods are disclosed for concentrating one or more components in a fluid effluent, which comprises fractions comprising separated components of interest. The fluid effluent is passed through a concentration device comprising a hollow element comprising a wall at least a portion of which is porous wherein the hollow... Agent: Agilent Technologies Inc.

20070077545 - Sperm protective polypeptides and uses thereof: The present invention relates to polypeptides capable of binding chaperone receptors, composition and methods for protecting, restoring, or improving the physiological properties of sperm cells. More particularly, the invention relates to protection of the motility, survival, fertility capability, resistance to cooling, freezing, and thawing of sperm cells put in contact... Agent: David S. Resnick Nixon Peabody

20070077547 - Assay assembly: A cell based assay assembly includes a biochip assembly, a liquid delivery unit and detection and recording equipment is used for conducting an assay on a biological cell as it is delivered through the biochip assembly. The biochip assembly includes a plurality of separate biochips each comprising a microchannel with... Agent: Birch Stewart Kolasch & Birch

20070077552 - High throughput screen for inhibitors of polypeptide aggregation: We have developed a high through-put screen capable of isolating inhibitors of polypeptide aggregation, such as Alzheimer's Disease polypeptide Aβ aggregation, or other disease state aggregating proteins, from amidst large libraries of candidate inhibitors. The screen uses a fusion of a polypeptide domain that self-aggregates, such as an Aβ42 domain... Agent: Connolly Bove Lodge & Hutz LLP 1007 North Orange Street

20070077548 - Method for determination of cardiovascular risk factors in dried blood: A method for the determination of cardiovascular risk factors in biological samples that comprising the steps of a) sampling, b) altering the sample into a dry blood sample c) conducting a sample preparation where appropriate and d) analysing the sample to offer a simple yet effective method for the determination... Agent: William Collard Collard & Roe, P.C.

20070077551 - Sample analyzer: A sample analyzer for analyzing samples of a plurality of species of animals, comprising: a display; a memory for storing first icon data representing a first icon and second icon data representing a second icon, the first icon showing a first species of animal and being used for selecting a... Agent: Brinks Hofer Gilson & Lione

20070077550 - Sample imaging apparatus, sample analyzing apparatus, and sample imaging method: A sample imaging apparatus comprising: a sample image obtainer for obtaining an image of a sample smeared on a sample holder, the sample holder comprising an identification part which comprises identification information of the sample; an identification detector for detecting the identification information; an identification part image obtainer for obtaining... Agent: Brinks Hofer Gilson & Lione

20070077549 - Violet laser excitable dyes and their method of use: The present invention provides dye compounds optimally excited at about 400 nm and have a Stokes shift of at least about 80 nm. These dyes find use in detection of analyte in a sample and the preparation of dye-conjugates.... Agent: Invitrogen Corporation C/o Intellevate

20070077555 - Adsorption system for the removal of viruses and viral components from fluids, in particular blood and blood plasma: The present invention relates to an adsorption system for the removal of viruses and viral components, in particular hepatitis C viruses, from physiological fluids, in particular whole blood or blood plasma, by means of extracorporeal adsorption processes, as well as to an adsorber material for use in the adsorption system... Agent: Kagan Binder, PLLC

20070077553 - Bioinformatically detectable group of novel vaccinia regulatory genes and uses thereof: The present invention relates to a group of novel viral RNA regulatory genes, here identified as “viral genomic address messenger genes” or “VGAM genes”, and as “Viral genomic record” or “VGR genes”. VGAM genes selectively inhibit translation of known host target genes, and are believed to represent a novel pervasive... Agent: Rosetta-genomics

20070077554 - Homologous viral internal controls for use in rt-pcr assays of enteric viruses: Homologous viral internal controls have been developed for use in RT-PCR assays of a number for viruses. Two of these internal controls, such as for HAV and Norwalk virus, are cloned on a single plasmid, thereby making them useful for the multiplex detection of these viruses in a single reaction.... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070077574 - family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof: An isolated polynucleotide at least 60% homologous to SEQ ID NO: 1, 3, 5 or 18 encoding a SARP polypeptide; vectors comprising a polynucleotide sequence encoding at least 11 consecutive amino acids of αSARP polypeptide; a host cell transformed with an isolated polynucleotide or vector; antibodies specific for SARP and... Agent: Sheridan Ross PC

20070077584 - Adenovirus status as a predictor of body composition change, disease status, and treatment outcomes: Infection with obesifying adenoviruses in animals and humans may be used to predict changes in body weight and disease status. More particularly, infection with certain adenoviruses, such as adenovirus type 36 (Ad-36) and adenovirus type 37 (Ad-37) may cause removal of the normal equilibrium factors that control fat cell metabolism... Agent: Mcguirewoods, LLP

20070077583 - Alpha enolase-directed diagnostics and therapeutics for cancer and chemotherapeutic drug resistance: Disclosed are methods for detecting a neoplasm and/or chemotherapeutic drug resistance or angiogenic potential in neoplastic cells by detecting an increase in the expression of α-enolase in such cells, or in the case of metastatic potential on the surface of such cells, as compared to the level of expression of... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070077589 - Altered recombinases for genome modification: The present invention describes methods of identifying altered recombinases and compositions thereof, wherein at least one amino acid is different from a parent, wild-type recombinase and the altered recombinase has improved recombination efficiency towards wild-type and/or pseudo att site sequences relative to the parent, wild-type recombinase. The present invention also... Agent: Bozicevic, Field & Francis LLP

20070077580 - Biochemical treatment apparatus and method comprising liquid handling mechanism: Nucleic acid solution, magnetic particles solution and primer or eluate are moved between a lot of wells provided in reaction/storage vessel 3 by pipette device 40 to perform the first PCR, purification and the second PCR. In the time point where the first PCR and purification end, pipette tip 42... Agent: Fitzpatrick Cella Harper & Scinto

20070077585 - Compositions and methods for il13 biomarkers: Compositions and methods are provided for measuring and determining biomarkers for IL-13.... Agent: Philip S. Johnson Johnson & Johnson

20070077572 - Compositions and methods for in vitro sorting of molecular and cellular libraries: The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water-in-oil-in-water emulsion. The emulsion includes a continuous... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070077576 - Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins: Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070077561 - Detection of transgenes of genetically modified organisms using pyro luminescence: The present application provides a method for identifying the presence of a transgene of a genetically modified organism in a sample wherein the nucleic acid sequence of the transgene is replicated and detected as the release of PPi from the deoxynucleotide triphosphate precursors consumed in the replication reaction. This pyro... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070077578 - Diagnosis of (a risk of ) disease and monitoring of therapy: The invention provides a method for typing a sample of an individual suffering from, or at risk of suffering from, a disease and a method for monitoring treatment of an individual suffering from a disease comprising determining whether a sample from the individual comprises an expression product of AC133 in... Agent: Trask Britt

20070077566 - High stability, high activity coatings and processes for using same: The present invention relates to a high stability, high activity coating and processes for using the same. The coating has high biocatalytic activity and stability useful on surface of various materials and fibers, e.g., polymer fibers applicable in heterogeneous environments. In one illustrative approach, enzyme “seed” are covalently attached to... Agent: Battelle Memorial Institute Attn:IPServices, K1-53

20070077567 - High stability, high activity materials and processes for using same: The present invention relates generally to high stability, high activity biocatalytic materials and processes for using the same. The materials comprise enzyme aggregate coatings having high biocatalytic activity and stability useful in heterogeneous environment. These new materials provide a new biocatalytic immobilized enzyme system with applications in bioconversion, bioremediation, biosensors,... Agent: Battelle Memorial Institute Attn:IPServices, K1-53

20070077579 - In vitro sorting method: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070077569 - Isomaltulose synthases, polynucleotides encoding them and uses therefor: The invention is directed to novel enzymes that convert sucrose to isomaltulose. More particularly, the present invention discloses novel sucrose isomerases, polynucleotides encoding these sucrose isomerases, methods for isolating such polynucleotides and nucleic acid constructs that express these polynucleotides. Also disclosed are cells, including transformed bacterial or plant cells, and... Agent: Proskauer Rose LLP

20070077586 - Maternal chelation for embryo, fetal, and infant benefit: This invention teaches the use of chelating agents to diagnose and treat metal toxins in a patient. Chelation agents are given to the mother for the benefit of the baby. Metal toxins such as lead, arsenic, mercury, tin, antimony, aluminum and others are known to cause miscarriages, birth defects, maldevelopment... Agent: Husch & Eppenberger, LLC

20070077560 - Method and system for rapidly conferring a desired trait to an organism: A method is provided for regulating the conversion rate of a hereditary trait of a cell, comprising the step of regulating the error-prone frequency of gene replication of the cell. A method is provided for producing a cell having a regulated hereditary trait, comprising the step of (a) regulating an... Agent: Seed Intellectual Property Law Group PLLC

20070077558 - Method for evaluating quality of beef such as taste and texture on the basis of genotype of stearoyl-coa desaturase: We paid attention to stearoyl-CoA desaturase gene, and investigated the relation between this gene and the unsaturated fatty acid content in beef fat. As a result, we found that the unsaturated fatty acid content was associated with the genotype of this gene, classified according to several single nucleotide polymorphisms (SNPs)... Agent: Posz Law Group, PLC

20070077573 - Method for extracting dna from sample of organism: A method in which DNA is extracted from a precious sample of organism simply and efficiently without being contaminated by impurities is provided. The method for extracting DNA comprises of: 1) a process for pretreatment having; a procedure for obtaining fragments by using a whole sample of organism of hard... Agent: Oliff & Berridge, PLC

20070077557 - Method for identifying type-1 interferon responsive ms patients by determining trail expression: This invention relates to a method for identifying MS patients susceptible to type I-Interferon (IFN), in particular IFN-β, and for monitoring IFN therapy in MS patients by determining TRAIL gene and/or protein expression as a marker.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070077582 - Method for quantitative detection of short rna molecules: Described herein are approaches to the detection and quantitation of short RNAs in a biological sample. The methods permit the detection and quantitation of individual species of short RNA in a nucleic acid sample, both singly and in a multiplex format that permits the determination of expression levels for two... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070077587 - Method of detecting a biopolymer and device for the same: Provided is a method of achieving a simple, quick, and highly accurate detection and measurement of a biopolymer, and to provide a device for this purpose. To this end, a method of detecting a biopolymer utilizing two kinds of solvent phases different in property from each other, including steps of:... Agent: Reed Smith LLP Suite 1400

20070077563 - Method of searching for functional nucleotide molecule: A universal method of searching for a nucleic acid capable of effectively inhibiting gene expression; a nucleic acid construct to be used in this method; a vector; and a kit for the above method. This method is characterized in that a nucleic acid construct, which is a nucleic acid construct... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070077571 - Methods and apparatus for identifying allosterically regulated ribozymes: Compositions and methods are provided to use regulatable aptazymes for controlling gene expression and in assays to detect the presence of ligands or to detect activation by an effector of an aptazyme bound to a solid support such as a substrate or multi-well plate. Regulatable aptazymes are ribozymes that are... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070077570 - Multiplexed amplification of short nucleic acids: The present teachings provide methods, compositions, and kits for reverse transcribing and amplifying small nucleic acids such as micro RNAs. High levels of multiplexing are provided by the use of a zip-coded stem-loop reverse transcription primer, along with a PCR-based pre-amplification reaction that comprises a zip-coded forward primer. Detector probes... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070077559 - Newcastle disease virus administration: A mammalian subject having a tumor is treated by a method comprising administering an effective amount of a Newcastle disease virus, wherein the virus is administered to the subject in one or more cycles; and at least one cycle comprises administering sequentially one or more initial doses of from 1.8×1010... Agent: Lewis J Kreisler Legal Department

20070077588 - Non-fluorescent energy transfer: The present invention relates generally to the transfer of non-fluorescent energy between donor and acceptor moieties. In certain embodiments, the invention provides biomolecules that include substantially non-fluorescent donor moieties. Processes involving these donor moieties typically entail reduced background fluorescence relative to applications that involve conventional fluorescent donor moieties. In addition... Agent: Quine Intellectual Property Law Group, P.C.

20070077591 - Novel polypeptide: A screening tool and a screening method for a therapeutic agent for type II diabetes, particularly an agent for alleviating insulin resistance are disclosed. A novel polypeptide, a polynucleotide, a vector, a promoter, and a transformant which are useful in the screening tool and the screening method, are also disclosed.... Agent: Sughrue Mion, PLLC

20070077581 - Oncoprotein protein kinase: An isolated polypeptide (JNK) characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and Threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of deterction of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP

20070077568 - Process for preparing high stability, high activity coatings and processes for using same: A process for preparing high stability, high activity biocatalytic coatings is disclosed attachable to various materials and fibers, and processes for using same. The process involves attaching crossslinked enzyme aggregates to various materials and fibers forming a biocatalytic coating characterized by high biocatalytic activtity and high stability. The coated materials... Agent: Battelle Memorial Institute Attn:IPServices, K1-53

20070077565 - Process for preparing high stability, high activity materials and processes for using same: A process for preparing high stability, high activity biocatalytic materials is disclosed and processes for using the same. The process involves coating of a material or fiber with enzymes and enzyme aggregate providing a material or fiber with high biocatalytic activity and stability useful in heterogeneous environments. In one illustrative... Agent: Battelle Memorial Institute Attn:IPServices, K1-53

20070077577 - Proliferation markers in clinical practice and their use for cancer prognosis or diagnosis: The invention relates to a method for assessing the proliferative state of cells in a human or non human biological sample, comprising using Chromatin Assembly Factor-1 (CAF-1 in short) subunits as proliferation markers. Application for cancer prognosis or diagnosis and monitoring tumor response in therapy.... Agent: Buchanan, Ingersoll & Rooney PC

20070077562 - Rapid nucleic acid isolation method and compositions: A method of isolating RNA from a biological specimen is provided, whereby a biological specimen is contacted with an admixture of (i) a mono-phasic solution of phenol and guanidine isothiocyanate and (ii) a lysis buffer under conditions and for a time appropriate to form a homogenate. Next, the homogenate is... Agent: Welsh & Katz, Ltd

20070077564 - Reactive surfaces, substrates and methods of producing same: Reactive surfaces, substrates and methods of producing and using such substrates and surfaces are provided. The substrates and surfaces provide low density reactive groups preferably on an otherwise non-reactive surface for use in different applications including single molecule analyses.... Agent: Pacific Biosciences Of California, Inc.

20070077590 - Snail, a new marker for tumour invasion and target protein of new antitumoral compounds: The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumour cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumour marker, indicative of... Agent: Dann, Dorfman, Herrell & Skillman

20070077556 - Tumor associated antigens and methods of using the same: The present invention provides methods and compositions for the diagnosis of hyperproliferative disease and autoimmune disease. Tumor associated antigens, nucleic acids encoding them and antibodies to the tumor associated antigens are provided for the diagnosis of hyperproliferative disease, such as, for example, ovarian cancer, breast cancer, lung cancer, colorectal cancer,... Agent: Townsend And Townsend And Crew, LLP

20070077575 - Use of rna polymerase as an information-dependent molecular motor: Materials and methods are described in which the information dependence of RNA polymerase is employed to enable its use as a molecular motor adaptable for movement within DNA grid arrays and to actuate, move, position or alter cargo such as physical structures and normally inanimate substances and objects.... Agent: Hoffman Warnick & D'alessandro, LLC

20070077594 - Electroluminescent device: The invention relates to a matrix of electroluminescent organic material having quantum dots embedded therein. Electrodes provide electrons and holes to the matrix forming excitons to be transferred to the quantum dots. The invention provides transfer molecules on the quantum dots facilitating the transfer of excitons from the electroluminescent organic... Agent: Philips Intellectual Property & Standards

20070077592 - Hemipteran glutamate decarboxylase: Novel nucleic acid sequences encoding hemipteran L-glutamate decarboxylases, and the amino acid sequence of such protein are disclosed. Methods of making and using the same are disclosed.... Agent: John M. Sheehan Fmc Corporation

20070077597 - Method for identifying modulators of g protein coupled receptor signaling: This invention relates to methods for identifying peptides and other compounds which block or enhance G protein coupled receptor mediated signaling with high affinity and specificity and/or which stabilize a particular conformer of a G protein coupled receptor. Assays, methods of treatment and other methods developed in conjunction with these... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070077598 - Methods of diagnosis, prognosis and treatment of cardiovascular disease: The invention provides methods for diagnosis or prognosis of cardiovascular disease involving the detection of an elevated amount of MIC-1 in a test body sample. The invention also provides methods for treatment of cardiovascular disease and other chronic inflammatory disease.... Agent: Nixon & Vanderhye, PC

20070077595 - Miniaturized spectometer using optical waveguide and integrated raman system on-chip: One embodiment relates to an analyzer having an interferometer, a detector and a microprocessor, wherein the analyzer does not contain a spectrometer having a dispersive grating, the interferometer is to create a phase shift in an original spectrum of electromagnetic radiation emitted from a sample and Fourier transform the original... Agent: Morrison & Foerster LLP

20070077599 - Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith: The present invention relates to optical bio-disc systems and related methods and to immobilizing receptor molecules. When a sample is injected into a fluidic circuit, the target agent binds to a capture probe bound in a capture zone. A signal is generated from tags attached to a reporter probe that... Agent: Knobbe Martens Olson & Bear LLP

20070077593 - Substrate as a ligate carrier: Described is a substrate for use as a ligate carrier in a method for detecting ligate-ligand association events, having test sites 24 disposed on the substrate and having ligates 26 bound to the surface of the test sites 24, at least two types of test sites 24 being provided, the... Agent: Crockett & Crockett

20070077596 - Trace incorporation of fluorescent monomer facilitating quality control of polymerization reactions: The present invention provides a polymer that includes a trace amount of a luminescent moiety. The polymers have unique properties that make them ideally suited for use in diverse analyses, including desorption/ionization mass spectrometry of analytes. The invention also provides a device that incorporates the polymeric compositions of the inventions,... Agent: Townsend And Townsend And Crew LLP

20070077602 - Gpr35 and modulators thereof for the treatment of metabolic-related disorders: The present invention relates to a method for identifying a metabolic stabilizing compound, comprising: a) contacting a candidate compound with GPR35, and b) determining whether GPR35 functionality is increased, wherein an increase in GPR35 functionality is indicative of the candidate compound being a metabolic stabilizing compound. The invention further relates... Agent: Arena Pharmaceuticals, Inc.

20070077600 - Methods and kits for distinguishing between specific and non-specific protein associations: The present invention is method of determining whether or not associations between a given protein and other proteins in a cell are specific. The method comprises (a) providing a first sample of the cells in which the given protein contains a tag, (b) providing a second sample of the same... Agent: Hoffmann & Baron, LLP

20070077601 - Reagent kit fr determining characteristic of tissue: A reagent kit that is used for determining a characteristic of tissue obtained from a patient is described. The reagent kit comprising expression measurement reagents for measuring expression level of cyclin-dependant kinase (CDK) and activity measurement reagents for measuring activity value of CDK. The expression measurement reagents comprise first reagents... Agent: Brinks Hofer Gilson & Lione

20070077604 - Diagnostic device and method: A method of separating a cell-containing sample into a substantially cell-depleted portion, and a cell-containing portion comprising at least one of a stem cell, a lymphocyte, and a leukocyte comprises a step in which the sample is received in a vessel flexible wall. In another step, an additive and particles... Agent: Rutan & Tucker, LLP Robert D. Fish

20070077605 - Methods and apparatus for blood typing with optical bio-discs: This invention relates to clinical diagnostic assays, related optical bio-discs, and a disc-reading apparatus. The invention is directed to methods and apparatuses for performing immunohematology assays using an optical bio-disc analysis system. The invention is further directed to an optical bio-disc for performing an immunohematologic assay including a substrate having... Agent: Knobbe Martens Olson & Bear LLP

20070077606 - Methods and compositions to correlate trichomonas infection with prostate cancer: The present invention provides methods and compositions for identifying a subject at increased risk of having prostate cancer by detecting an antibody that specifically binds a Trichomonas α-actinin protein in a sample of the subject.... Agent: Myers Bigel Sibley & Sajovec

20070077603 - Elisa to detect multimeric forms of a protein: The present invention provides methods of detecting multimeric forms of protein S, or other proteins in plasma, complex mixtures, and tissue samples. The invention further provides methods of diagnosing a subject as having or as being at risk for having a multimeric protein-associated disease. The invention further provides methods of... Agent: The Scripps Research Institute

20070077608 - Busulfan immunoassay: Novel conjugates of busulfan and novel busulfan immunogens derived from α-substituted derivatives of busulfan and antibodies generated by these busulfan linked immunogens are useful in immunoassays for the quantification and monitoring of busulfan in biological fluids.... Agent: Gibbons, Del Deo, Dolan, Griffinger & Vecchione

20070077607 - Novel screening method: The present invention provides a method for identifying a drug-like compound, or lead compound for the development of a drug-like compound, which is capable of modulating cellular adhesion and/or cell survival comprising the step of testing said compound for an ability to modulate the binding of a complex of tissue... Agent: Fish & Richardson PC

20070077609 - Bioluminescence resonance energy transfer (bret) systems and methods of use thereof: Briefly described, embodiments of this disclosure include bioluminescence resonance energy transfer (BRET) systems, methods of detecting a protein-protein interaction, noninvasive methods for detecting the interaction of a first protein with a second protein within a living animal, methods to determine the efficacy of a test compound administered to modulate the... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070077610 - Membrane system for blood coagulation testing: An article for testing a coagulation process in whole blood.... Agent: Katharine A. Jackson Huebsch Medtronic Inc.

20070077611 - Membrane system for blood coagulation testing: An article and methods for testing a coagulation process in whole blood.... Agent: Katharine A. Jackson Huebsch Medtronic, Inc.

20070077612 - Membrane system for blood coagulation testing: Articles for testing a coagulation process in whole blood.... Agent: Katharine A. Jackson Huebsch Medtronic, Inc.

20070077613 - Membrane system for blood coagulation testing: A method of calculating a result of a coagulation process in whole blood and a computer readable medium providing instructions for same.... Agent: Katharine A. Jackson Huebsch Medtronic, Inc.

20070077614 - Uses of lp-pla2 in combination to assess coronary risk: This invention relates to a method for assessing risk of Coronary Vascular Disease (CVD). Specifically, it relates to utilizing risk assessment from both Lipoprotein Associated Phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) in combination. In addition the invention relates to a method for assessing risk of Coronary Vascular Disease (CVD)... Agent: Licata & Tyrrell P.C.

20070077615 - Methods and apparatus for automated spore-culturing and monitoring: Processes and apparatus for functioning, subsequent to exposure to a designated microbial-biocidal treatment-cycle, for automated measurement, reporting, and recording, along with treatment-cycle data, for verifying effectiveness of each such treatment-cycle, by automatically monitoring a respective biological-indication (B-I) Test Ampoule for such a cycle. Prior burdensome requirements on personnel, in establishing... Agent: Raymond N. Baker Shanley & Baker, P.l.l.c.

20070077616 - Biosynthesis of isopentenyl pyrophosphate: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the... Agent: Bozicevic, Field & Francis LLP

20070077618 - Efficient production method of ascopyrone p: A method for producing ascopyrone P from 1,5-D-anhydrofructose efficiently is provided. The method produces ascopyrone P by heating a solution of 1,5-D-anhydrofructose at a pH of 10 or less and a temperature of 100° C. or higher.... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070077617 - Polypeptide cleavage method using ompt protease variant: A polypeptide cleavage method characterized in that arginine or lysine is at the P1 position of a desired cleavage site in a polypeptide, an amino acid other than aspartic acid, glutamic acid or proline is at the P1′ position, a single basic amino acid or two or three consecutive basic... Agent: Drinker Biddle & Reath (dc)

20070077622 - Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070077626 - Polypeptides sharing sequence identity with a fibroblast growth factor polypeptide and nucleic acids encoding the same: The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences,... Agent: Genentech, Inc.

20070077621 - Production of cpd glycosylases: Recombinant forms of DNA sequences for CPD glycosylases, including the bacteriophage T4 gene denV, are described that are capable of expression at high levels. Active CPD glycosylases can be recovered from inclusion bodies resulting from the high expression using, for example, a homogenization process which employs stream mixing, and the... Agent: Maurice M Klee

20070077625 - Purification of polypeptides: A method for purifying a desired heterologous polypeptide from microbial fermentation broth or homogenate in which it is produced and solubilized is described. This method involves adding to the broth or homogenate an effective amount of a solution of 6,9-diamino-2-ethoxyacridine lactate (ethacridine lactate) to precipitate host cell impurities under conditions... Agent: Genentech, Inc.

20070077624 - Recombinant production of mixtures of antibodies: The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention... Agent: Trask Britt

20070077623 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Heller Ehrman LLP

20070077619 - Secretion of proteins from yeasts: The present invention relates to expression constructs encompassing the nucleic acid sequence coding for a shuttle peptide construct processable by yeast cells; to corresponding expression vectors comprising such constructs; to methods carried out with the aid thereof for recombinant preparation of target proteins; to hosts transformed therewith; to shuttle peptides... Agent: Connolly Bove Lodge & Hutz, LLP

20070077620 - Site specific incorporation of phosphoserine into polypeptides using phosphoseryl-trna synthetase: Nucleic acids encoding genes with SepRS and tRNASep activity for site specific incorporation of phosphoserine into a protein or polypeptide and methods of use thereof are described. Typically, SepRS preferentially aminoacylates tRNASep with O-phosphoserine and the tRNASep recognizes at least one codon such as a stop codon. In a preferred... Agent: Patrea L. Pabst Pabst Patent Group LLP

20070077627 - Murine zcytor17 ligand polypeptides and polynucleotides: The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for stimulating the immune system, and proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing... Agent: Zymogenetics, Inc. Intellectual Property Department

20070077628 - Polynucleotides, polypeptides and antibodies and use thereof in treating tsg101-associated diseases: An isolated polynucleotide is provided. The isolated polynucleotide encodes a polypeptide having a sequence of at least 10 and no more than 500 amino acids, wherein said sequence is derived from the amino acid sequences of SEQ ID NO: 2, 4 or 6. Also provided are compositions and methods using... Agent: Martin D. Moynihan Prtsi, Inc.

20070077629 - Method for modifying nucleotide chain: A method for modifying a nucleotide chain, which includes: allowing a catabolic enzyme specific to a nucleotide sequence containing a specific base such as hypoxanthine (Hx) to act on a nucleotide chain (I) to be modified having the above described nucleotide sequence containing a specific base on the 3′-terminal side... Agent: Steptoe & Johnson LLP

20070077630 - Methods for enhancing the degradation or conversion of cellulosic material: The present invention relates to methods for degrading or converting a cellulosic material and for producing a substance from a cellulosic material.... Agent: Novozymes, Inc.

20070077631 - Genes encoding genetic stability, gene expression and folding proteins: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.... Agent: Lahive & Cockfield, LLP

20070077632 - Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme: Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior optical purity and yield. At this time, the hydrolytic enzyme is selected from the group consisting of Savinase, Alcalase, Novozym 243, Everlase, Esperase, Protease 7 and Acylase,... Agent: Darby & Darby P.C.

20070077633 - Manufacture of amides: A method of producing an amide from the corresponding nitrile comprising the following steps, i) providing a microorganism capable of producing a nitrile hydratase biocatalyst, ii) culturing the microorganism in a growth medium, iii) storing the microorganism, iv) contacting the nitrile by the microorganism in an aqueous medium and thereby... Agent: Ciba Specialty Chemicals Corporation Patent Department

20070077634 - Microorganism: A microorganism which is Rhodococcus rhodochrous strain NCIMB 41164 or a mutant thereof. A method of culturing the microorganism in a culture medium comprising urea or urea derivative is claimed. A nitrite hydratase obtainable from the microorganism is claimed. Also claimed is a process of preparing an amide from the... Agent: Ciba Specialty Chemicals Corporation Patent Department

20070077636 - Methods of making compositions comprising a uv-absorbing chromophore: wherein at least two of R1, R2, and R3 are non-fatty acid carboxylates, and the other of R1, R2, and R3 are each either a C2-C24 fatty acid moiety, OH, or a non-fatty acid carboxylate, wherein the first and second non-fatty acid carboxylates, when present, are the same or different,... Agent: Conley Rose, P.C.

20070077637 - Microorganisms that extracellularly secrete lipids and methods of producing lipid and lipid vesicles encapsulating lipids using said microorganisms: There are provided microorganisms having a property of producing a lipid containing unsaturated fatty acids as constituent fatty acids and extracellularly secreting the produced lipid encapsulated in lipid vesicles, methods of screening said microorganisms, as well as methods of efficiently producing a fatty acid-containing lipid using said microorganisms. Furthermore, there... Agent: Drinker Biddle & Reath (dc)

20070077638 - Microorganisms that extracellularly secrete lipids and methods of producing lipid and lipid vesicles encapsulating lipids using said microorganisms: There are provided microorganisms having a property of producing a lipid containing unsaturated fatty acids as constituent fatty acids and extracellularly secreting the produced lipid encapsulated in lipid vesicles, methods of screening said microorganisms, as well as methods of efficiently producing a fatty acid-containing lipid using said microorganisms. Furthermore, there... Agent: Drinker Biddle & Reath (dc)

20070077635 - Obtaining fatty acid esters from native oils and fats: Process and device for obtaining fatty acids or fatty acid esters from native oils and fats by their enzymatic hydrolysis and optional simultaneous esterification with alcohols, especially n- and iso-alcohols Process and device for obtaining fatty acids or fatty acid esters from native oils and fats, in which lipases, as... Agent: Quarles & Brady LLP

20070077639 - Estimation of activity or inhibition of processes involved in nucleic acid modification using chemiluminescence quenching: A method for determining the activity of a substance capable of altering the structure of a nucleic acid molecule from a first to a second state which is based upon the use of labelled nucleic acid molecules and/or complementary oligonucleotides. The label is a chemiluminescent molecule and a corresponding quencher... Agent: Gen Probe Incorporated

20070077640 - Organic compounds: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for... Agent: Klarquist Sparkman, LLP

20070077641 - Methionine aminopeptidase and methods of use: Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20070077642 - Steroid receptor modulation of gene expression: The present invention provides a novel steroid inducible expression system in a non-mammalian host cell (e.g., fungal) that is independent of metabolic and developmental regulation. The human estrogen receptor gene expressed in Aspergillus, under a constitutive promoter, was shown to be functional. A construct containing a promoter from Aspergillus, synthetic... Agent: Merck And Co., Inc

20070077643 - Biochemical processing apparatus equipped with display device: An index region consisting of indexes corresponding to a plurality of processing steps is provided. The job in progress is indicated by changing the display state of the corresponding index. Detailed information on the job in progress is displayed in an information display region, which is provided in a different... Agent: Fitzpatrick Cella Harper & Scinto

20070077644 - Bioassay substrate with feeder wirings: Provided is a configuration of feeder wirings for electrodes provided for reaction regions arranged in multiplicity on a disk-shaped substrate. Feeder wirings extended from a current passing portion (U) provided at a central portion of a substrate (A) to electrodes provided in reaction regions (R) arranged in multiplicity on the... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070077645 - Biochemical treatment device with dispensing unit: The width of reaction wells and detection wells used for the same sample in a nozzle line direction is made to fall within an area smaller than the pitches of nozzle holding parts, so as to minimize a moving range and enable a pipette action for preventing contamination.... Agent: Fitzpatrick Cella Harper & Scinto

20070077646 - Apparatus for performing biochemical processing using a container with a plurality of wells and the container for the apparatus: A biochemical processing apparatus for performing biochemical processing in a container having a plurality of wells capable of holding liquid includes an opening/closing mechanism configured to open or close a lid capable of hermetically and selectively sealing the plurality of wells.... Agent: Fitzpatrick Cella Harper & Scinto

20070077648 - Apparatus for performing biochemical processing using container having wells: A biochemical processing apparatus includes a thermal cycle section, a processing section for performing a processing not requiring heating or cooling, and a cooling section. These sections are arranged in that order and opposed to a container with a plurality of wells.... Agent: Fitzpatrick Cella Harper & Scinto

20070077647 - Temperature controller for structure: A temperature controller for controlling temperature of a first structure having a first flat face comprises a second structure having a second flat face for planar contact with the first flat face, a pressure-applying means for pressing the first structure, a second supporting means for supporting the second structure to... Agent: Fitzpatrick Cella Harper & Scinto

20070077652 - Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells: Methods of ex-vivo expansion and at the same time inhibiting differentiation of stem cells by co-culture with mesenchymal cells, transplantable populations of renewable progenitor and stem cells expanded thereby, and their uses in therapeutic applications.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070077651 - Peptides for enhanced cell attachment and growth: The present invention relates to cell adhesion promoting (“CAP”) peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion resistant “CAR”. The invention provides combination of peptides that, when covalently coupled to a CAR layer such as hyaluronic acid that has been created... Agent: Becton, Dickinson And Company Alston & Bird LLP

20070077650 - Rapid production of high titer virus: The invention includes methods of producing viral particles which include introducing into avian cells a nucleotide sequence encoding a replication deficient retroviral vector and introducing into the avian cells nucleotide sequences encoding products required for replication of the replication deficient retroviral vector under the control of a promoter that is... Agent: Avigenics, Inc.

20070077649 - Transplantable cell growth niche and related compositions and methods: Provided is a method of culturing a successor cell from a precursor cell comprising co-culturing a precursor cell such as, without limitation, a human embryonic stem cell or a neuronal stem cell with an adult mesenchymal stem cell. In one embodiment, the adult mesenchymal stem cell is derived from adipose... Agent: Jesse A. Hirshman, Esq.

20070077653 - Modulation of cell intrinsic strain to control matrix synthesis, secretion, organization and remodeling: The present invention provides methods for manipulating the intrinsic strain of cells by treating tissue engineered constructs or native tissue with compounds which affect the intrinsic strain setpoint of the cells in order to modulate matrix synthesis, secretion, organization and/or remodeling so that the tissues withstand in vivo mechanical forces... Agent: The Webb Law Firm, P.C.

20070077654 - Platelets from stem cells: Human embryonic stem cells are induced to differentiate first into the hematopoietic lineage and then into megakaryocytes, the cells which generate platelets. The proper in vitro culture of megakaryocytes results in the production and shed of platelets. This makes possible, for the first time, the in vitro production of a... Agent: Quarles & Brady LLP

20070077655 - Labels, containers, system and method for providing reagents: The invention relates to systems and methods for marketing and using products such as liquid materials, especially liquid reagents for use in microbiological and cellular biological laboratory settings include the use of unique color and simple numeric or alphanumeric identifiers to quickly and easily identify any product from a catalog... Agent: Vinson & Elkins, L.L.P.

20070077656 - Microelectronic positioning for bioparticles: The present invention provides a method for microelectronic positioning bioparticles, which utilizes dielectric and non-contact electrical force of cell themselves associated with multi-phase electrical signals to attain uniformity of distribution of the bioparticles and positioning thereof within micro-areas in a cell culture system. The obstacle of system geometrical structure is... Agent: Bacon & Thomas, PLLC