Chemistry: molecular biology and microbiology inventions 04/07

20070092860 - Sperm suspensions for use in insemination: The present invention provides a method of cryopreserving sperm that have been selected for a specific characteristic. In a preferred embodiment, the method is employed to freeze sex-selected sperm. Although the cryopreservation method of the invention can be used to freeze sperm selected by any number of selection methods, selection... Agent: Santangelo Law Offices, P.C.

20070092865 - Detection and characterization of psychoactives using parallel multi-site assays in brain tissue: This invention relates to methods and devices for the detection and characterization of psychoactive compounds by analyzing alterations of network level physiological characteristics before and after the introduction of a candidate sample onto an in vitro neuronal tissue sample. The invention further provides a software package that enables an operator... Agent: Morrison & Foerster LLP

20070092861 - Environments that maintain function of primary liver cells: Surfaces useful for cell culture comprise a support to which is bound a CAR material, and, bound to the CAR material, an ECM protein, or a biologically active fragment or variant thereof such as elastin, fibronectin, vitronectin, lamninin, collagen I, collagen III, collagen IV, and collagen VI. Also, optionally present... Agent: Becton, Dickinson And Company Alston & Bird LLP

20070092862 - Flow sensors for penile tumescence: The disclosure describes blood flow sensors for detecting penile tumescence. A system according to the invention may include at least one sensor for sensing blood flow into the penis, and one sensor for sensing blood flow away from the penis. Detecting penile tumescence may be accomplished by comparing the flow... Agent: Shumaker & Sieffert, P. A.

20070092863 - Methods and agents of decalcifying bone: Decalcification can be performed by using acid or other agents. It may be difficult to decalcify large bone block within ours. This invention provides a bone-decalcifying agent including a calcium desolving agent for desolving calcium ions of bones, and a bubble-forming agent for generating microbubbles when the bone-decalcifying agent is... Agent: Buchanan, Ingersoll & Rooney PC

20070092864 - Treatment planning methods, devices and systems: Treatment planning methods, devices and systems. One of the treatment planning methods includes displaying at least a portion of a set of lungs and one or more potential treatment regions; receiving a selection of a target treatment region from among the one or more potential treatment regions; and displaying one... Agent: Fulbright & Jaworski L.L.P.

20070092867 - Application using non-covalent bond between a cucurbituril derivative and a ligand: Provided are a kit including a first component that is a compound of formula (1) below bound to a first material and a second component that is a ligand bound to a second material, wherein each of the first and second materials is independently selected from the group consisting of... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070092866 - Avian adenoassociated virus and uses thereof: The present invention provides an Avian adeno-associated virus (AAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAAV vectors and particles. Methods of isolating the AAAV are provided.... Agent: National Institute Of Health C/o Needle & Rosenberg, P.C.

20070092870 - Detection of biomolecules: Compositions, systems and methods for the detection of analytes with labeled nanostructures are provided. In particular, compositions and systems including labeled nanostructures for detecting a biomolecule of interest, and methods of use thereof, are provided.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070092868 - Liquid crystal cassette: A functional cassette for the detection of ligands comprises a first inner housing, a second middle housing and a third outer housing and each housing is at least partially rotatable relative to an adjoining housing. The first inner housing contains a central well adapted for receiving a sample, and the... Agent: Hahn Loeser & Parks, LLP

20070092871 - Microarray for pathogen identification: There is disclosed a microarray device for pathogen identification and for subtyping influenza A. Pools of primers are disclosed and used to amplify any subtype of influenza A. Pathogen identification includes influenza A, influenza B, parainfluenza virus, adenovirus, enterovirus, rhinovirus, human metapneumovirus, respiratory syncytal virus, herpes simplex viruses, SARS coronavirus,... Agent: Combimatrix Corporation

20070092869 - Spike-in controls and methods for using the same: Methods, compositions, and kits for performing a one-color analysis of microarray data are provided. Also disclosed are compositions including control nucleic acid sequences, and methods for measuring the dynamic range of a microarray analysis.... Agent: Agilent Technologies Inc.

20070092882 - Analysis of microrna: Methods are described in which a sample containing miRNA is contacted with an array having a probe set, followed by interrogating the array to assess binding to the probe set. Probes, probe sets, arrays comprising a probe set, and kits incorporating the probe sets are also described.... Agent: Agilent Technologies Inc.

20070092872 - Apparatus and method for sequencing a nucleic acid: Disclosed herein are methods and apparatuses for sequencing a nucleic acid. These methods permit a very large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides.... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20070092901 - Automated sample-to-microarray system: An apparatus having within or as part of a housing; a sample port; a microarray port; a lysis module; a purification module for containing a solid phase for binding of oligonucleotides; a thermocycling module for containing a polymerase chain reaction; a fragmentation module; and a microarray module for holding a... Agent: Naval Research Laboratory Associate Counsel (patents)

20070092877 - Bcrm-1 genes and uses thereof: A polypeptide capable of conferring multidrug-resistance on a cell is disclosed. Also disclosed are nucleic acids encoding the polypeptide, expression vectors, trasformant host cell lines expressing the polypeptide, and antibodies binding to the polypeptide. Screening, diagnostic and treatment methods using the above polypeptide, nucleic acids, antibodies and host cell lines... Agent: Fish & Richardson PC

20070092905 - Compositions and methods for analyzing immobilized nucleic acids: The present invention provides methods of detecting a nucleic acid analyte in a sample. The methods generally involve modifying immobilized nucleic acids from a sample onto an insoluble support in a substantially elongated configuration, where modification generates an identifying feature that identifies the analyte; and detecting the identifying feature(s) using... Agent: Bozicevic, Field & Francis LLP

20070092898 - Detection of multiple anti-viral antibodies: The present invention relates to methods and kits for the diagnosis and monitoring of hepatitis C virus (HCV) infection and/or Kaposi's sarcoma herpesvirus infection (KSHV) in a subject, as well as other infectious diseases and agents. In particular, the present invention relates to the diagnosis and monitoring of infectious disease... Agent: Medlen & Carroll, LLP

20070092888 - Diagnostic markers of hypertension and methods of use thereof: The present invention relates to methods for the diagnosis and evaluation of cardiovascular illness, particularly hypertension treatment. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for hypertension treatment and one or more non-specific... Agent: William C. Fuess

20070092873 - Digital identification of genetic materials and methods for acquiring data for it: The present invention relates to methods using HIPK1 sequences for use in diagnosis and treatment of lymphoma and leukemia. In, addition, the present invention describes the use of these compositions for use in screening methods.... Agent: Paul & Barbara Gentry

20070092896 - Extreme thermophile single-stranded dna binding mutant protein, and nucleic acid isothermal amplification method of use thereof: The invention establishes a technology that allows non-specific amplification to be inhibited during nucleic acid amplification in an isothermal amplification reaction, such that the amplification efficiency is increased. The invention is a extreme thermophile single-stranded DNA binding mutant protein, having an amino acid sequence that expresses a function that can... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070092879 - Fluoresence-based dna primase assays: The present invention provides methods for assaying the activity of DNA primases and methods for screening for compounds that modulate the activity of DNA primases.... Agent: Astrazeneca R&d Boston

20070092881 - Gene markers of tumor metastasis: The invention concerns the study of tumor metastasis in a NOD/SCID/γcnull transgenic mouse model and the identification of tumor markers, including markers of tumors with high metastatic potential, using information obtained in this mouse model.... Agent: Heller Ehrman LLP

20070092878 - In vitro method to detect bladder transitional cell carcinoma: The present invention refers to an in vitro method to detect a bladder transitional cell carcinoma, in an individual, to determine the stage or severity of this cancer in an individual or to monitor the effect of therapy administered to an individual with this cancer; to screen for, identify, develop... Agent: Kramer & Amado, P.C.

20070092880 - Invasive cleavage reaction with electrochemical readout: A universal tag assay is disclosed wherein at least one invasive cleavage reaction (ICR) is used to generate tagged molecules having identifier tags corresponding to target nucleotide sequences, and further wherein hybridization of any tagged molecule with a complementary detection probe on a universal detector indicates the presence of the... Agent: Knobbe Martens Olson & Bear LLP

20070092897 - Labeled probe bound object, method for producing the same and method for using the same: A method for labeling an object, which is effective when multiple types of labels are given as necessary even to a very small object such as a fine particulate substrate for use in fixation of biological substances such as probe molecules or nucleic acid primers that are used for a... Agent: Fitzpatrick Cella Harper & Scinto

20070092875 - Map2k6 as modifier of branching morphogenesis and methods of use: Human MAP2K6 genes are identified as modulators of branching morphogenesis, and thus are therapeutic targets for disorders associated with defective branching morphogenesis function. Methods for identifying modulators of branching morphogenesis, comprising screening for agents that modulate the activity of MAP2K6 are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20070092876 - Method and system for cell and/or nucleic acid molecules isolation: The present invention relates to methods and system for tissue cell and/or nucleic acid molecule isolation. In particular, to a method for isolating nucleic acid molecules from tissue samples comprising: i) treating a tissue sample with at least one enzyme for tissue dissociation; ii) adding a lytic solution; and iii)... Agent: Ostrolenk Faber Gerb & Soffen

20070092906 - Method and system for delivering nucleic acid into a target cell: Controlled delivery of nucleic acid into adhered of cells is achieved by immobilizing the nucleic acid and the cells to a substrate. Improved control over delivery is achieved by immobilizing the nucleic acid to the substrate via complimentary DNA binding interactions with an oligonucleotide linker.... Agent: Quarles & Brady LLP

20070092884 - Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a bac-based dna library: application to the detection of mycobacteria: A method for detecting Mycobacterium tuberculosis involves contacting a biological sample with the product of expression of at least one ORF contained in a polynucleotide present in Mycobacterium tuberculosis and absent in Mycabacterium bovis BCG; and detecting whether an immunological complex is formed between the product thereof and antibodies contained... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070092904 - Method for preparing limiting quantities of nucleic acids: The present invention relates generally to the amplification of nucleic acids. More specifically, the present invention facilitates amplification of total RNA for a variety of purposes, including analysis utilizing nucleotide assays, constructing cDNA libraries, in situ hybridization, and TaqMan. Additionally, the present invention facilitates amplification of total RNA isolated from... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.

20070092890 - Methods and compositions for detecting autoimmune disorders: The invention provides methods and compositions useful for detecting autoimmune disorders.... Agent: Genentech, Inc.

20070092886 - Methods and compositions for diagnosis, monitoring and development of therapeutics for treatment of atherosclerotic disease: Polynucleotide sequences are provided that correspond to genes that are differentially expressed in atherosclerotic disease conditions. Methods for using these sequences to detect gene expression and/or for transcriptional profiling in mammals are also provided. The polynucleotide sequences of the invention may be used, for example, to diagnose atherosclerotic disease, to... Agent: Morrison & Foerster LLP

20070092891 - Methods and compositions for identifying biomarkers useful in diagnosis and/or treatment of biological states: The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological... Agent: Wilson Sonsini Goodrich & Rosati

20070092892 - Methods and compositions for identifying biomarkers useful in diagnosis and/or treatment of biological states: The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological... Agent: Wilson Sonsini Goodrich & Rosati

20070092893 - Methods and compositions for identifying cancer-related biomarkers: The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated by such transcription factor biomarkers. The invention also relates to identifying polymorphisms in such transcription factors and regulated genes indicative of the biological... Agent: Wilson Sonsini Goodrich & Rosati

20070092894 - Methods and kits for detecting single nucleotide polymorphisms of chromosome implicated in premature canities: Methods and kits for diagnosing a predisposition to premature canities in an individual are disclosed. A method for diagnosing a predisposition to premature canities in an individual comprises detecting at least one SNP marker of the human chromosome 9, selected from the group consisting of rs306534, rs3739902, rs575916, and rs365297.... Agent: Buchanan, Ingersoll & Rooney PC

20070092902 - Methods for detection of promoter polymorphism in ugt gene promoter: The present invention is directed to methods for detecting the presence of genetic polymorphisms that correlate with altered gene expression. More specifically, the present invention is directed to methods for detecting the genetic polymorphisms located in the UGT1A1 promoter. The invention also provides methods for optimizing drug dosages based upon... Agent: Fulbright & Jaworski L.L.P.

20070092900 - Methods for diagnosing and characterizing breast cancer and susceptibility to breast cancer: Methods and kits for diagnosing and characterizing breast cancer or a susceptibility to breast cancer are described herein. Diagnosis and characterization methods comprise detecting the BARD1 Cys557Ser allele or a haplotype comprising the BARD1 Cys557Ser allele in patients with or without a familial predisposition to cancer. The methods described herein... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070092887 - Methods for generating polynucleotides having desired characteristics by iterative selection and recombination: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to... Agent: Maxygen, Inc. Intellectual Property Department

20070092895 - Methods for identifying genes that increase yeast stress tolerance, and use of these genes for yeast strain improvement: Disclosed are methods for identifying genes that increase stress tolerance of yeast, list of identified genes, and use of these genes for improving yeast strains for better survival and performance during ethanolic fermentation.... Agent: Nath & Associates

20070092907 - Methods of screening compound probes: Briefly described, embodiments of this disclosure include methods for identifying compound probe candidates, methods of screening compound probe candidates, methods of preparing molecular imaging probes, high throughput methods for identifying molecular imaging probes in a library, and the like.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070092883 - Methylation specific multiplex ligation-dependent probe amplification (ms-mlpa): An improved multiplex ligation-dependent amplification method is disclosed for detecting the presence of specific methylated sites in a single stranded target nucleic acid, while simultaneously, the quantification of the target nucleic acid sequence can be performed, using a plurality of probe sets of at least two probes, each of which... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070092909 - Molecular markers for identification of fat and lean phenotypes in chickens: The invention provides molecular methods of screening chickens to determine those more likely to have a lean or fat phenotype by identifying the presence of at least one polymorphism in genetic material of a chicken in the thyroid hormone repressible gene (THRG) or its 3′ untranslated region (SEQ ID NO:... Agent: Connolly Bove Lodge & Hutz LLP P.o. Box 2207

20070092899 - Multiple displacement amplification with blocker dna: A method of whole genome amplification of a nucleic acid sample comprising providing a starting template of the nucleic acid sample, bringing the template together with blocking DNA, bringing the template together with DNA polymerase, and multiple displacement amplification of the template. The method can be used with a starting... Agent: Eddie E. Scott

20070092903 - One-color microarray analysis methods, reagents and kits: Microarray platforms for performing one-color and two color analyses using a single platform are provided. Methods of using the microarray platforms and analyzing data obtained from such microarrays are also provided.... Agent: Agilent Technologies Inc.

20070092889 - Parkinson's disease-related disease compositions and methods: Compositions and methods for use in the therapeutic and preventative treatment, study, diagnosis and prognosis of PD-related disease are disclosed. Also provided are kits and reagents for prognosis and diagnosis of PD-related disease and related conditions.... Agent: Perlegen Sciences, Inc. Legal Department

20070092874 - Plasma or serum marker and process for detection of cancer: This disclosures provides, in one aspect, a method for detecting non-clinically diagnosed cancer in a patient. In one embodiment, the method includes extracting blood serum or plasma from the patient, and then detecting beta-catenin RNA in the blood serum or plasma. In addition, in this embodiment, the method includes determining... Agent: Baker & Mckenzie LLP

20070092908 - Renaturation, reassociation, association and hybridization of nucleic acid molecules: The present invention features methods and compositions for the renaturation, hybridization, association, or reassociation of nucleic acids that combines both acceleration of the reaction rate and improved specificity.... Agent: Bozicevic, Field & Francis LLP

20070092885 - Secreted proteins: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.... Agent: Foley And Lardner LLP Suite 500

20070092910 - Alcohol dehydrogenase sequences useful for developing compounds for the prevention and/or treatment of metabolic diseases: The present invention relates to nucleotide sequences, particularly those of SEQ ID NO's 2, 7 and 9 that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds for the prevention and treatment of metabolic diseases such as diabetes and... Agent: Wolf Greenfield & Sacks, PC

20070092914 - Compartmentalised screening by microfluidic control: The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070092911 - Methods and compositions for diagnosis and /or prognosis in systemic inflammatory response syndromes: The present invention relates to methods and compositions for symptom-based differential diagnosis, prognosis, and determination of treatment regimens in subjects. In particular, the invention relates to methods and compositions selected to rule in or out SIRS, or for differentiating sepsis, severe sepsis, septic shock and/or MODS from each other and/or... Agent: Barry S. Wilson Foley & Lardner LLP

20070092913 - Methods for identifying agents that modulate gpr105 activity: In one aspect, the present invention provides methods for determining whether a chemical agent modulates the biological activity of a GPR105 protein. The methods of this aspect of the invention include the steps of: (a) contacting a living cell, in vitro, with a chemical agent, wherein the living cell expresses... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20070092912 - Uses of human zven antagonists: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070092917 - Biomarkers for screening, predicting, and monitoring prostate disease: Gene expression data are analyzed using learning machines such as support vector machines (SVM) and ridge regression classifiers to rank genes according to their ability to separate prostate cancer from BPH (benign prostatic hyperplasia) and to distinguish cancer volume. Other tests identify biomarker candidates for distinguishing between tumor (Grade 3... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20070092918 - C-type lectin transmembrane antigen expressed in human prostate cancer and uses thereof: A novel gene (designated PC-LECTIN) that is highly overexpressed in prostate cancer and its encoded protein is described. PC-LECTIN in normal human tissues is restricted to testis, but is highly expressed in prostate cancer. Consequently, PC-LECTIN provides a diagnostic and/or therapeutic target for prostate cancer.... Agent: Agensys C/o Morrison & Foerster LLP

20070092916 - Diagnostic method for diseases by screening for hepcidin in human or animal tissues, blood or body fluids and therapeutic uses therefor: The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin protein, including prohepcidin and fragments thereof, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding... Agent: Fox Rothschild LLP Princeton Pike Corporate Center

20070092915 - Method and composition for analyzing a carbohydrate polymer: Disclosed is a method for characterizing carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070092919 - Monitoring of liquids for disease-associated materials: A method for monitoring liquids for the presence of disease-associated materials, so as to provide a non-invasive means for the detection of various materials associated with cancer, autoimmune, neuro-degenerative and other disorders. The method provided comprises contacting a sample of the liquid with a solid, non-buoyant particulate material having free... Agent: Beyer Weaver LLP

20070092921 - Monoclonal and polyclonal antibodies to equine albumin and hemoglobin and apparatus and methods using the antibodies in the identification and localization of ulcers and other digestive tract bleeding in equines: A diagnostic and testing apparatus and related methods for the use of the same are disclosed which derive and use antibodies to equine albumin and equine hemoglobin in testing apparatus, kits, and methods for detecting and localizing gastric and colonic ulcers or bleeding in horses. Fecal droppings from a horse... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator

20070092920 - Serum prolactin binding protein in epithelial carcinoma: The present invention relates to antibodies that have specificity towards prolactin binding protein (PRLBP) that is either bound to a binding partner or unbound to a binding partner, as well as antibodies towards PRLBP regardless of the binding state of PRLBP. The present invention also provides methods of using these... Agent: Invitrogen C/o Intellevates Sughrue Mion PLLC

20070092922 - Taxol immunoassay: Novel conjugates of taxol and novel taxol immunogens derived from the 9 and 7 positions of taxol and monoclonal antibodies generated by these taxol linked immunogens are useful in immunoassays for the quantification and monitoring of taxol in biological fluids.... Agent: Gibbons P.C.

20070092923 - Establishing a long-term profile of blood sugar level aiding self-control of the same: Establishing a long-term profile of blood sugar level aiding self-control of the same includes periodically obtaining a specimen from a patient, and detecting a response of the specimen. Obtaining a blood sugar value of the patient based on the response, and storing the blood sugar values periodically measured. Establishing a... Agent: Berkeley Law & Technology Group, LLP

20070092926 - Analysis of protein isoforms using unique tryptic peptides by mass spectrometry and immunochemistry: A method for qualitatively and quantitatively detecting a protein isoform (p450 isozyme) in a sample using MALDI-TOF mass spectrometry or immunochemistry using a unique proteolytic peptide for the isoform. Relative and absolute quantitation can be performed using calibration curves with P450 isozyme-specific peptide standards.... Agent: Stinson Morrison Hecker LLP Attn: Patent Group

20070092925 - Method of treating skin by delivering specific protein stabilizers/protectors to skin proteins and methods of selecting said stabilizers: The invention provides methods of treating skin by delivering specific protein stabilizers/protectors to skin proteins, as well as to methods of selecting said stabilizer.... Agent: Unilever Intellectual Property Group

20070092924 - Process for treatment of protein samples: The process of the invention comprises 1) preparing a dry porous support incorporating one or more biomolecule-modifying reagents, 2) applying a biomolecule-containing sample solution to said support wherein the volume of said sample is equal to or less than the imbibition capacity of said support so that the sample is... Agent: Hendricks And Associates

20070092927 - Photocatalytic particles with directed and controlled redox activity: A modified particle. The modified particle comprises: a semiconductor particle which is photoactivatable; and a modifier molecule attached to the semiconductor particle, wherein the modifier molecule includes an electrochemically reversible redox active site which is photoexcitable. Bioconjugated nanoparticle probes, Redox-NSs and methods of using these modified particles are also described.... Agent: Dinsmore & Shohl LLP

20070092928 - Method of evaluating elimination of microoganisms and apparatus for evaluating elimination of microorganisms: The sterilizing effect of particle irradiation on microorganisms for the sterilizing treatment thereof can be evaluated. The evaluation can be done by supplying microorganisms in the space inside a container (8), allowing particles (7) for the sterilizing treatment of microorganisms to irradiate the microorganisms, sampling the microorganisms by a sampling... Agent: Birch Stewart Kolasch & Birch

20070092929 - Test system for the determination of the presence of an antibiotic in a fluid: Provided is a test system, a test method and a test kit based on a test medium comprising Bromothymol Blue or a structurally related indicator.... Agent: Nixon & Vanderhye, PC

20070092930 - Process for enhanced recovery of crude oil from oil wells using novel microbial consortium: The present invention provides a microbial consortium containing three hyperthermophilic, barophilic, acidogenic, anaerobic bacterial strains for enhanced oil recovery from oil reservoirs where temperatures range from 70° C. to 90√ C. The said microbial consortium is unique in producing a variety of metabolic products mainly CO2, methane, biosurfactant, volatile fatty... Agent: Birch Stewart Kolasch & Birch

20070092931 - Biosynthesis of isopentenyl pyrophosphate: Methods for synthesizing isopentenyl pyrophosphate are provided. A first method comprises introducing into a host microorganism a plurality of heterologous nucleic acid sequences, each coding for a different enzyme in the mevalonate pathway for producing isopentenyl pyrophosphate. A related method comprises introducing into a host microorganism an intermediate in the... Agent: Bozicevic, Field & Francis LLP

20070092932 - Method of producing xanthophyll: The present invention provides a method for producing a xanthophyll from a photosynthetic microalga, which includes inoculating a photosynthetic microalga containing a xanthophyll, preferably an encysted microalga, into a nutrient medium to grow the microalga; and encysting the grown microalga, by a single-step culture method in which the growth step... Agent: Le-nhung Mcleland

20070092940 - Cysteine engineered antibodies and conjugates: e

20070092938 - Diagnostics for sars virus: This invention relates to Severe Acute Respiratory Syndrome associated coronavirus (SARS virus) isolated and recombinant proteins, in particular the nucleocapsid (N) protein and spike (S) protein, as well as fragments thereof and their use in the diagnosis, treatment and prevention of Severe Acute Respiratory Syndrome (SARS). The proteins and fragments... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070092939 - Human immunodeficiency virus entry inhibitor assay: The present invention is a method for evaluating the ability of a compound to prevent the Human Immunodeficiency Virus (“HIV”) from entering into a T cell. The method involves fusing a first cell line that mimics HIV viral particles by expressing a gp120-gp41 complex on the cell surface and that... Agent: Cheryl Liljestrand Tanox, Inc.

20070092944 - Hybrid glycosylated products and their production and use: The present invention relates to hybrid glycosylated products, and in particular, to natural products such as polyketides and glycopeptides, and to processes for their preparation. The invention is particularly concerned with recombinant cells in which a cloned microbial glycosyltransferase can be conveniently screened for its ability to generate specific glycosylated... Agent: Dann, Dorfman, Herrell & Skillman

20070092937 - Method of producing target protein, fusion protein and gene thereof, protein consisting of partial sequence of intein and gene thereof, expression vector, and transformant: It is intended to provide techniques whereby a target protein is efficiently obtained as a normal protein even in the case of a protein which can be hardly expressed by usual recombinant DNA techniques. A fusion protein composed of a molecular chaperone, an intervening protein having an activity of cleaving... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070092935 - Novel bacillus bagcel cellulase: The present invention provides a novel cellulase nucleic acid sequence, designated BagCel, and the corresponding BagCel amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BagCel, recombinant BagCel proteins and methods for producing the same.... Agent: Genencor International, Inc. Attention: Legal Department

20070092934 - Novel bacillus mhkcel cellulase: The present invention provides a novel cellulase nucleic acid sequence, designated mHKcel, and the corresponding mHKcel amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding mHKcel, recombinant mHKcel proteins and methods for producing the same.... Agent: Victoria L Boyd Genencor International Inc

20070092946 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070092945 - Phospholipase: The present invention is related to a method for producing a phospholipase by processing an expressed fungal peptide and to certain specified phospholipases. Furthermore the invention provides a method for producing cheese with a phospholipase.... Agent: Novozymes North America, Inc.

20070092941 - Pro1298 polypeptides: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides... Agent: Heller Ehrman LLP

20070092933 - Production of multimeric fusion proteins using a c4bp scaffold: The present invention provides a method for obtaining a recombinant fusion protein comprising a scaffold of a C-terminal core protein of C4bp alpha chain, said recombinant fusion protein being capable of forming multimers in soluble form in a prokaryotic host cell, the method including the steps of (i) providing a... Agent: Nixon & Vanderhye, PC

20070092936 - Severe acute respiratory syndrome: The present invention relates, in general, to severe acute respiratory syndrome and, in particular, to a method of generating neutralizing antibodies to the virus. The invention further relates to methods of detecting the presence of the virus and to methods of treating infected individuals.... Agent: Nixon & Vanderhye, PC

20070092942 - Ubiquitin specific enzymes of family herpesviridae: Disclosed is a new class of deubiquitinating enzymes that are conserved across the family Herpesviridae.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070092943 - Versatile vectors for expression of foreign proteins in photosynthetic bacteria: Methods for expressing and purifying foreign (heterologous) proteins in photosynthetic organisms employ expression of both heterologous membrane proteins and a means for compartmentalizing or sequestering of the protein.... Agent: Barnes & Thornburg LLP

20070092947 - Methods and compositions for increasing longevity and protein yield from a cell culture: Disclosed herein are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. By transfecting cells in culture with an apoptosis-inhibiting gene or vector, cells in culture... Agent: Faegre & Benson LLP Patent Docketing

20070092948 - Novel human kunitz-type inhibitors and methods relating thereto: The present invention provides isolated DNA molecules comprising a DNA segment encoding novel human Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the... Agent: Zymogenetics, Inc. Intellectual Property Department

20070092949 - Method of converting beta-1,4-glucan to alpha-glucan: A method for production of an α-glucan from a β-1,4-glucan is provided, comprising: reacting a solution containing β-1,4-glucan, a primer, a source of phosphoric acid, β-1,4-glucan phosphorylase, and α-1,4-glucan phosphorylase to produce an α-glucan. In this method, said β-1,4-glucan may be cellobiose, and said β-1,4-glucan phosphorylase may be cellobiose phosphorylase.... Agent: Mark D. Saralino (general) Renner, Otto, Boisselle & Sklar, LLP

20070092950 - Process for preparing l-threonine: The invention provides an improved process for the fermentative preparation of L-threonine using L-threonine-producing bacteria from the family Enterobacteriaceae.... Agent: Fitch, Even, Tabin & Flannery

20070092951 - Alleles of the zwf gene from coryneform bacteria: The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.... Agent: Law Office Of Michael A. Sanzo, LLC

20070092952 - Glutamate 2,3-aminomutases and methods of use thereof: There are provided nucleic acids, including isolated DNA molecules, which encode glutamate 2,3-aminomutase enzymes, polypeptides produced from such nucleic acids and methods of making the nucleic acids and polypeptides. There are further provided methods of producing β-glutamate from glutamate using glutamate 2,3-aminomutase.... Agent: Foley & Lardner LLP

20070092953 - Method for producing l-glutamine by fermentation and l-glutamine producing bacterium: L-Glutamine is produced by culturing a coryneform bacterium which has L-glutamine producing ability and has been modified so that its intracellular glutamine synthetase activity should be enhanced, preferably which has been further modified so that its intracellular glutamate dehydrogenase activity should be enhanced, in a medium to produce and accumulate... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070092954 - Production of polyketides: Recombinant Myxococcus host cells can be used to produce polyketides, including epothilone and epothilone analogs that can be purified from the fermentation broth and crystallized.... Agent: Townsend And Townsend And Crew, LLP

20070092955 - Fermentative production of lipids on an industrial scale using chemically defined media: We describe the use of chemically defined media for the fermentative production of valuable compounds on an industrial scale. Microbial strains which are suitable for fermentation on an industrial scale using a chemically defined medium include fungal, yeast and bacterial strains. Suitable strains can be obtained as wild type strains... Agent: Nixon & Vanderhye, PC

20070092956 - Methods and materials for the production of organic products in cells of candida species: The present invention relates to biocatalysts that are cells, optimally of the Crabtree-negative phenotype, comprising expression vectors encoding genes heterologous to the cell that enable increased production of organic products. More specifically, the invention relates to genetically modified Candida cells, methods for making the Candida cells, and their use in... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070092957 - Fermentive production of four carbon alcohols: Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium expressing an isobutanol biosynthetic pathway.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070092958 - Method and apparatus for guiding growth of neurons: This invention pertains to a method and apparatus for facilitating guided growth of axons and dendrites in cell culture, for example for studies of axonal pathfinding, target cell selection, synapse formation, synaptic physiology, neuronal plasticity, drugs screening and gene perturbations. In a preferred embodiment, the invention includes a semiconducting substrate... Agent: Fish & Richardson P.C.

20070092959 - Removal of plasmin(ogen) from protein solutions: A method for specifically removing or isolating plasmin(ogen) or plasmin in presence of fibrinogen from a mixture containing plasmin(ogen) or plasmin by contacting the mixture with a rigid amino acid wherein the amino group of the amino acid and the carboxylic group of the amino acid are about 6-8 Angstroms,... Agent: Jacobson Holman PLLC

20070092960 - Method for high throughput volumes in the fractionation of bio-molecules by chromatographic systems: The present invention provides industrial scale expanded bed adsorption process for fractionation and isolation of bio-molecules from fluids, preferably proteins from milk and whey, in a cost-effective manner. This is accomplished by operating the expanded bed column at high temperatures of at last 40° C., combined with applying flow rates... Agent: Foley And Lardner LLP Suite 500

20070092961 - Process to cultivate brevundimonas diminuta for filtration validation: The present invention relates to a method for culturing Brevundimonas diminuta for filtration validation. The method comprises inoculating the B. diminuta cells in an appropriate medium, growing the inoculated medium in a gas-impermeable chamber, wherein there is room for air in the headspace of the chamber, wherein air is continually... Agent: Merck And Co., Inc

20070092962 - Carbon neutralization system (cns) for co2 sequestering: A device and method for carbon dioxide sequestering involving the use of a photo-bioreactor with Light Emitting Diodes (LED's) for the cost-effective photo-fixation of carbon dioxide (CO2). This device and method is useful for removing undesirable carbon dioxide from waste streams.... Agent: Bracewell & Giuliani LLP

20070092963 - Device to the preparation of cutting edge capable samples: A device for the processing of samples which can be cut, in particular histological tissue samples, where the device comprises a processing tray (1) with a processing surface (2) and with at least two trimming inserts (3) for laying in and cutting the samples by means of knives, is characterized... Agent: Alston & Bird LLP

20070092964 - Ion detection using a pillar chip: The present invention provides methods and assemblies for ion detection of samples using a chip with elevated sample zones. The elevated sample zones provide a number of ion detection advantages over chips with non-elevated sample zones. Embodiments of the invention have a number of applications in drug discovery, environmental analyses... Agent: Townsend And Townsend And Crew, LLP

20070092965 - Culture of goblet cells: The invention encompasses isolation, culture and characterization of goblet cells in vitro from mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans, rats, mice, rabbits and the like. In another aspect of the invention, the culture of goblet cells has a concentration of pure... Agent: Weingarten, Schurgin, Gagnebin & Lebovici LLP

20070092966 - In vitro tumor angiogenesis model: Provided is a method of inducing tubulogenesis in normal endothelial cells comprising co-culturing the normal endothelial cells with tumor cells and forming tubules from the normal endothelial cells.... Agent: David W. Highet, Vp And ChiefIPCounsel Becton, Dickinson And Company

20070092967 - Method of isolating and culturing mesenchymal stem cell derived from umbilical cord blood: The present invention relates to a method of isolating and culturing mesenchymal stem cells using umbilical cord blood that is most ideal for cell therapy. The method comprises adding an anti-coagulant to umbilical cord blood having a volume of more than 45 ml per unit, which is obtained within 24... Agent: Venable LLP

20070092968 - Novel htmc promoter and vectors for the tumor-selective and high-efficient expression of cancer therapeutic genes: Promoters that include a tissue-selective promoter sequence and a second promoter sequence operatively coupled to the tissue-selective promoter sequence, wherein the second promoter sequence includes a minimal viral promoter sequence, are disclosed. Nucleic acids and compositions that include these promoter sequences are also disclosed. Also disclosed are methods of improving... Agent: Fulbright & Jaworski L.L.P.

20070087320 - Medium for conservation of organs, biological tissues or living cells: The object of the present invention is a preservation medium for living organs, biological tissues, and cells containing a liquid nutritive base, wherein it contains a high-molecular-weight hyaluronic acid and sodium chloride and wherein it contains no component of animal origin.... Agent: Clark & Brody

20070087321 - Post-thaw survival of chryopreserved biological material by hydrostatic pressure challenge: The present invention relates to a method for improving post-thaw survival of cryopreserved biological material comprising applying hydrostatic pressure to said biological material; keeping the said biological material at the hydrostatic pressure for a predetermined time period; releasing the hydrostatic pressure; and freezing the said biological material using any protocol... Agent: Hahn & Voight PLLC

20070087322 - Method of preserving early embryos of experimental animals by vitrification: This invention provides a solution for preserving mammalian early embryos or ES cells by vitrification, which comprises, as a base material, a phosphate buffer that exclusively contains 10% to 15% (v/v) propylene glycol as polyhydric alcohol or a phosphate buffer that exclusively contains 10% to 15% (v/v) propylene glycol and... Agent: Heller Ehrman LLP

20070087324 - Method of providing readily available cellular material derived from peripheral blood: Process for preparing a peripheral blood cell composition in a TVEMF-bioreactor.... Agent: Ladas & Parry LLP

20070087323 - Sampling system: A device for collecting and storing a biological sample for subsequent analysis, comprising tamper-evident storage means for storing said sample, said storage means being suitable for digestion together with said biological sample.... Agent: Fulbright & Jaworski L.L.P.

20070087327 - Method and kit-of-parts for the electrophysiological examination of a membrane comprising an ion channel: The invention relates to a collection (kit-of-parts) for producing a high electrical resistance in an electrophysiological examination of a membrane comprising an ion channel, comprising a first electrolytic solution and a second electrolytic solution, wherein the first electrolytic solution comprises 20-140 mM divalent cations of a first element and the... Agent: Ip Strategies

20070087328 - Method of coating lipid membranes: Method for the manufacturing of a supported lipid membrane comprising: providing a substrate, covered at least in part with a layer comprising proteins, glycoproteins, polypeptides and/or peptides; contacting and incubating said substrate with a solution comprising bicelles, which comprise at least one short chain and at least one long chain... Agent: Fulbright & Jaworski L.L.P.

20070087326 - Method of measuring the biological activity of an urotensin ii receptor: Administration of U-II to a cell having a functional urotensin II receptor caused an increase in the electrical impedance of the cell in a receptor specific and dose dependent manner. Thus, the present invention provides methods of measuring the biological activity of an U-II receptor by monitoring the electrical impedance... Agent: Philip S. Johnson Johnson & Johnson

20070087325 - Method of screening for cell colonies that express a soluble variant of a target protein: The present invention concerns a method of identifying a cell colony which expresses a soluble variant of a target protein which method comprises (a) subjecting the cell colony to conditions which are capable of causing lysis thereof; (b) filtering the lysate through a filter having pores which allow only soluble... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070087329 - Serum replacement for thyroid hormone-responsive cell culture: A low thyroid hormone serum supplemented culture medium is provided comprising serum prepared from non-mammalian vertebrates having a developmental stage with low endogenous thyroid hormone (T3 and T4) levels; and a culture medium. The culture medium is for the study of cellular responses to thyroid hormones or chemicals that induce... Agent: Klarquist Sparkman, LLP

20070087336 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Medlen & Carroll LLP

20070087337 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Medlen & Carroll LLP

20070087338 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Medlen & Carroll LLP

20070087339 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Medlen & Carroll LLP

20070087340 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Medlen & Carroll LLP

20070087341 - Compositions for use in identification of influenza viruses: The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by amplification of a segment of viral nucleic acid followed by molecular mass analysis.... Agent: Medlen & Carroll LLP

20070087335 - Human microrna targets in hiv genome and a method of identification thereof: The present invention relates to human microRNA targets in HIV genome and a method of identification thereof. Using multiple software targets to six human microRNAs [miRNAs] were discovered in the net, vpr, env, and I vif genes. The miRNAs were identified as hsa-miR-29a, hsa-miR-29b, hsa-miR-29c, hsa-mir-149, hsa-mir-324-5p, hsa-mir-378. These miRNAs... Agent: Harness, Dickey & Pierce, P.L.C

20070087333 - Method to detect antigen-specific cytolytic activity: The invention relates to a novel non-radioactive method to detect cytolytic activity that provides a measure of the existence and magnitude of an immune response against a particular antigen or immunogen. Provided is a method for detecting cytolytic activity of cells or a substance against a population of target cells,... Agent: Trask Britt

20070087334 - Pkr activation via hybridization chain reaction: The present application relates to the use of hybridization chain reaction (HCR) to form double stranded RNA polymers in the presence of a target, such as a nucleic acid associated with a disease or disorder. The RNA polymers are preferably able to activate the RNA-dependent kinase PKR. Activation of PKR... Agent: Knobbe Martens Olson & Bear LLP

20070087332 - Pulmonary stem cells, related methods and kits of parts: Isolated pulmonary stem cells, the isolated pulmonary stem cells being slowly dividing Oct-4 expressing cells forming individual colonies and able to undergoing terminal differentiation into a mature phenotype in vitro; a method to identify stem cells of a tissue; a kit for the identification of stem cell of a tissue;... Agent: Greenberg Traurig LLP

20070087331 - Selection of b cells with specificity if interest: method of preparation and use: The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides methods using a composition comprising an ordered and repetitive antigen or antigenic determinant array for visualization and selection of B cells specific for the antigen. These B cells are useful for the... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20070087330 - Viral deconstruction through capsid assembly in vitro: A cell-free method for translation and assembly of viral capsid and capsid intermediates is disclosed for use in deconstructing an unknown virus and for screening for compounds that inhibit assembly of viral capsids for the unknown virus.... Agent: Jonathan Alan Quine The Quine Intellectual Property Law Group, P.C.

20070087345 - Assays for the direct measurement of gene dosage: The present invention relates to compositions, methods, and kits for quantifying variations in gene copy number, e.g., of individual genes or of chromosomes or portions of chromosomes in an homogeneous reaction, without the need for target amplification, fragment size resolution, or microscopy.... Agent: Medlen & Carroll, LLP

20070087355 - Comparative genomic hybridization assays and compositions for practicing the same: Comparative genomic hybridization (CGH) assays and compositions for use in practicing the same are provided. Aspects of the methods include first preparing genomic templates from an initial genomic source by using precursors of circular template nucleic acids, e.g., padlock probes. The precursors include first and second domains that are at... Agent: Agilent Technologies Inc.

20070087359 - Detecting mutations in the feline cardiac myosin binding protein c gene associated with hypertrophic cardiomyopathy in cats: The invention pertains to methods for detecting the presence or absence of a mutation associated with hypertrophic cardiomyopathy in cats, particularly domesticated cats, and more particularly Maine Coon cats. The methods include detecting the presence or absence of a mutation in the feline MYBPC gene, and identifying feline subjects that... Agent: Calfee Halter & Griswold, LLP

20070087347 - Dose-dependent promoter originating in humans: It was found that a DNA consisting of a nucleotide sequence as set forth in SEQ ID NO: 1 having one sequence (SEQ ID NO: 2) unit, has a function of an initiator or a promoter. Therefore, it is provided a DNA consisting of a nucleotide sequence as set forth... Agent: Kilyk & Bowersox, P.l.l.c.

20070087366 - Functional mutant loxp sequences and uses thereof: The invention provides methods, kits, and compositions comprising novel mutant loxP sites. Such sites are particularly useful for procedures requiring multiple site-specific recombination reactions, including deletions or insertions of multiple genes or other sequences in the same organism, staged insertions or deletions of genes of the same organism at different... Agent: Stephen C. Macevicz Technology Development Office

20070087349 - Highly parallel template-based dna synthesizer: The invention relates to a template-based method for preparing nucleic acid double strands.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070087356 - In situ assembling of protein microarrays: The invention provides a microarray and methods for producing a protein microarray. The array comprises multiple nucleic acid molecules immobilized on a substrate, each comprising (i) a protein-binding domain and (ii) a nucleic acid sequence encoding a fusion protein comprising a polypeptide of interest and a DNA-binding protein that binds... Agent: Leydig, Voit & Mayer, Ltd.

20070087364 - In vitro erythroid micronucleus assay for genotoxicity: The present invention is directed to novel assays to measure the genotoxic effects of compounds on erythroid cells in vitro.... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20070087352 - Inhibitors for androgen antagonist refractory prostate cancer: The present invention relates to methods and antagonist compounds for modulating androgen receptor activity. The invention includes a method for identifying molecules that bind to a coactivator binding site of a receptor in the androgen receptor family. Also included is a cocrystal of an androgen receptor ligand binding domain complexed... Agent: Fish & Richardson P.C.

20070087372 - Isolated ductal fluid sample: A sample for diagnosis of breast cancer can be prepared by isolating a ductal fluid sample from one duct of a breast of a patient. The isolated ductal fluid is not mixed with ductal fluid from any other duct of the breast. Generally the target duct is not spontaneously discharging.... Agent: Cytyc Corporation

20070087357 - Lateral flow device with onboard reagents: Devices, methods and kits for conducting an assay to determine the presence or amount of an analyte in a fluid sample. The device includes a sample application element and a flow path matrix that facilitates fluidic flow by capillary action. The sample application element includes a non-absorbent or absorbent carrier... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070087354 - Lentiviral vector-based vaccine: Methods of eliciting humoral responses, methods of immunization, and methods of vaccination using lentiviral vector are disclosed. Additionally, immunogenic compositions and vaccines for West Nile Virus are disclosed.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.

20070087367 - Method and apparatus for combinatorial chemistry: A method and apparatus are provided for performing light-directed reactions in spatially addressable channels within a plurality of channels. One aspect of the invention employs photoactivatable reagents in solutions disposed into spatially addressable flow streams to control the parallel synthesis of molecules immobilized within the channels. The reagents may be... Agent: Luedeka, Neely & Graham, P.C.

20070087369 - Method for the isolation of rna from biological sources: Methods and kits for isolating RNA are provided that enable rapid RNA preparation from biological sources. In one aspect, RNA is isolated from difficult plant tissues and cells that contain high levels of secondary metabolites, without employing organic extraction or salt precipitation procedures. This method employs novel lysing and binding... Agent: Senniger Powers (sgm)

20070087343 - Method of detecting gene expression and kit and apparatus to be used therein: In an animal embryo or tissue, the following wholeamount treatment is carried out so that gene expression is detected. First, a sample such as an embryo or a tissue is fixed and then pretreated by acetylating an amine with acetic anhydride and eliminating lipids by using xylene. Next, in situ... Agent: Barnes & Thornburg LLP

20070087368 - Method, system and computer software providing a genomic web portal for functional analysis of alternative splice variants: A system for analyzing alternative splice variant sequences is described, comprising an input manager for receiving alternative splice variant sequences that are identified by one or more probe sets, a correlator that correlates functional domains with each of the alternative splice variant sequences and an associater that associates putative functions... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070087360 - Methods and compositions for detecting nucleotides: The present teachings generally relate to methods and materials for the detection of target nucleotides and/or the methylation state of target nucleotides.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070087377 - Methods and compositions for reverse translation: A process is disclosed by which a polynucleotide is directly synthesized from the peptide or protein that it encodes without the need for sequencing (or sequence analysis) of the peptide or protein. Information contained in the sequence of the peptide or protein is directly coupled, by the process of reverse... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20070087375 - Methods and compositions for treating cancer using 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710: The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710 genes in tissues relating to... Agent: Millennium Pharmaceuticals, Inc.

20070087344 - Methods for characterizing signaling pathways and compounds that interact therewith: The genes in a signaling pathway can be identified by over or under-expressing each member of a set of genes to be grouped in signaling pathways and measuring parameters under stimulatory conditions. Genes in a common signaling pathway give similar parameter profiles under such conditions. Moreover, the interactions between signaling... Agent: Bozicevic, Field & Francis LLP

20070087358 - Methods for diagnosing cancer based on dna methylation status in nbl2: The present invention relates to methods for diagnostic or prognostic assay for cancer based on analysis of altered methylation status at specific CpG dinucleotide sequences within the epigenetic marker, NBL2. The methods of the invention comprise determining the methylation status of a subregion of genomic CpG dinucleotide sequences within the... Agent: Jones Day

20070087365 - Methylation markers for diagnosis and treatment of ovarian cancer: Twenty-three markers are provided which are epigenetically silenced in ovarian cancers. The markers can be used diagnostically, prognostically, therapeutically, and for selecting treatments that are well tailored for an individual patient. Restoration of expression of silenced genes can be useful therapeutically, for example, if the silenced gene is a tumor-suppressor... Agent: Banner & Witcoff

20070087353 - Microarray biochemical reaction device: The microarray biochemical reaction device of this invention integrates microfluidic trenches with a microarray to form a serpentine microchannel passing through all DNA probes provided in the microarray. A sample solution is introduced into the microchannel and scrambled into discrete plugs to induce droplet mixing. The discrete plugs are then... Agent: Bacon & Thomas, PLLC

20070087370 - Microarray probe tm matching by selective destabilization: Methods and systems for designing oligonucleotide probes for use in microarray applications are provided herein. The described methods use duplex melting temperature (Tm) matching to destabilize the hybridization oligonucleotide probes to non-target sequences as compared to a target nucleotide sequence. Nucleic acid arrays containing probes selected by the described methods... Agent: Agilent Technologies Inc.

20070087373 - Optimization of immunomodulatory properties of genetic vaccines: This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.... Agent: Bingham, Mccutchen LLP

20070087374 - Optimization of immunomodulatory properties of genetic vaccines: This invention provides methods for obtaining molecules that can modulate an immune response, and immunomodulatory molecules obtained using the methods. The molecules find use, for example, in the tailoring of an immune response induced by a genetic vaccine for a desired purpose.... Agent: Bingham, Mccutchen LLP

20070087351 - Orotate transporter encoding maker genes: A recombinant marker gene encoding an orotate transporter polypeptide comprising an amino acid sequence at least 60% identical to SEQ ID NO: 2, a polynucleotide construct comprising at least one copy of the recombinant marker gene, a cell comprising at least one exogenous copy of the marker gene, and a... Agent: Novozymes North America, Inc.

20070087346 - Orthogonal gene switches: The present invention relates to an orthogonal gene switch for regulating the expression of a desired gene. The gene switch comprises a chimeric transcription factor that does not respond to endogenous ligands, and a ligand that is capable of activating the chimeric transcription factor but not endogenous transcription factors. The... Agent: Merck And Co., Inc

20070087362 - Polony fluorescent in situ sequencing beads: Miniaturized, high-density, bead-based arrays are provided. Methods of producing and using clonal beads and producing and using miniaturized, high density, bead-based arrays are also provided.... Agent: Banner & Witcoff, Ltd.

20070087378 - Polynucleotide and polypeptide fat metabolism regulators and uses thereof: In general, this invention relates to nucleic acid and amino acid sequences involved in fat metabolism regulation and the use of these sequences as targets for the diagnosis, treatment, and prevention of obesity and obesity-related diseases. In addition, the invention relates to screening methods for identifying modulators of body fat... Agent: Clark & Elbing LLP

20070087342 - Secreted proteins: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.... Agent: Foley And Lardner LLP Suite 500

20070087361 - Solid support assay systems and methods utilizing non-standard bases: Solid support assays using non-standard bases are described. A capture oligonucleotide comprising a molecular recognition sequence is attached to a solid support and hybridized with a target. In some instances, the molecular recognition sequence includes one or more non-standard bases and hybridizes to a complementary tagging sequence of the target... Agent: Eragen Biosciences, Inc. C/o Foley & Lardner LLP

20070087376 - Splice variants of pre-mrna transcripts as biomarkers in idiopathic neurodegenerative diseases: The present invention discloses a method to discover biomarkers indicative of an idiopathic neurodegenerative disease in a mammalian subject and biomarkers indicative of an idiopathic neurodegenerative disease in the mammalian subject. The biomarker comprises a splice variant mRNA of a precursor-messenger RNA (pre-mRNA) transcript of a gene in the mammalian... Agent: Everest Intellectual Property Law Group

20070087348 - System and method for carrying out multiple binding reactions in an array format: A method for determining one or more kinetic parameters of binding between a first binding member and a second binding member. The method comprises adsorbing the first binding member to a surface at a plurality of microspots. The second binding member is then presented to the first binding member at... Agent: Nath & Associates

20070087363 - Therapeutic methods, compounds and compositions: The invention provides methods of treating, preventing, delaying the onset, slowing the progression, or reversing the symptoms of Alzheimer's disease and other neurodegenerative diseases characterized by the accumulation of amyloid plaques comprising the Aβ42 peptide. The invention also provides compounds that reduce the production or secretion of the Aβ42-peptide by... Agent: Myriad Genetics Inc. Intellecutal Property Department

20070087350 - Use of a mutation in the braf gene for the determination of the malignancy of melanoma cells: The invention relates to the use of oligonucleotide probes comprising exon 15 of the BRAF gene or a part thereof comprising codon 599 for the detection of the malignancy of melanoma cells.... Agent: O'melveny & Myers

20070087379 - Ys68 gene involved in primitive hematopoiesis: A novel gene, dubbed “YS68”, involved in primitive hematopoiesis was successfully isolated from cDNA derived from mouse yolk sacs. In addition, a human gene corresponding to this gene was successfully isolated. Expression characteristics of these genes suggested their involvement in primitive hematopoiesis. The proteins of this invention and genes encoding... Agent: Fish & Richardson PC

20070087371 - Zinc finger domains and methods of identifying same: Disclosed is an in vivo selection method for identifying zinc finger domains that recognize any given target site. Also disclosed are the amino acid sequences of zinc finger domains that recognize particular sites.... Agent: Fish & Richardson PC

20070087389 - Control system using immune network and control method: To provide a new method for autonomously controlling the behavior of a control target device based on a stimulating action and a suppressing action among antibodies in an immune network, an operating unit 3 calculates an antibody concentration ai(t) serving as an index for selecting an antibody module ABi, while... Agent: Mcginn Intellectual Property Law Group, PLLC

20070087384 - Cynomolgus monkey dickkope-4, nucleotides encoding same, and uses thereof: The cynomolgus monkey Dickkopf-4 (cDkk-4) protein, isolated nucleic acid molecules which encode the cDkk-4 protein, and recombinant vectors and hosts comprising DNA encoding the cDkk-4 protein are disclosed. Also disclosed are methods for identifying analytes which interfere with the interaction between the cDkk-4 protein and a homologous or heterologous Dkk... Agent: Merck And Co., Inc

20070087386 - Diagnosis method of endometriosis by detecting biochemical markers and usage of these biochemical markers: The present invention relates to a non-invasive diagnosis method of endometriosis by detecting biochemical marker in serum or peritoneal fluid, in particular alpha 1-antitrypsin, fragments of alpha 1-antitrypsin, or a combination of both. The diagnosis of endometriosis is performed with observing in serum specimens of a patient the concentration and... Agent: Schmeiser, Olsen & Watts

20070087388 - G protein coupled receptor: The invention provides nucleic acid encoding a G protein coupled receptor (adenine binding GPCR) with specificity for adenine, isolated adenine binding GPCR, assay and treatment methods utilising the same.... Agent: Foley And Lardner LLP Suite 500

20070087383 - Immunoassay: The invention provides a method for detecting a hapten in a sample comprising the steps of: a) providing a sample potentially containing the hapten; b) providing a pre-determined amount of a first moiety, said first moiety being bound to a signaller and separated therefrom by a first linker, which first... Agent: Jacobson Holman PLLC

20070087387 - Method for the early detection of renal disease using proteomics: A method for the detection of an early biomarker for assessing a change in renal status in a mammalian subject following a renal event. The method typically includes the steps of (a) providing a body fluid sample obtained from a mammalian subject; (b) analyzing the molecular weight of the proteins... Agent: Hasse & Nesbitt LLC

20070087380 - Method of detecting auto-antibodies from patients suffering from rheumatoid arthritis, a peptide and an assay kit: The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9,... Agent: Morrison & Foerster LLP

20070087381 - Methods for constructing scdb libraries: Bispecific diabody libraries can be constructed from scFv libraries efficiently and without troublesome procedures by a single treatment, placing restriction enzyme sites appropriately for antigen-encoding regions.... Agent: Fish & Richardson PC

20070087382 - Molecule array and method for producing the same: The invention relates to assemblies for bonding molecules comprising bondable functional groups, which are present on a solid supporting material as individual molecular functional groups or multiple identical functional groups. Said assemblies are characterised in that the density of the individual functional groups or multiple functional groups on the solid... Agent: Fulbright & Jaworski L.L.P.

20070087385 - Spherical and magnetical silicagel carriers having an increase surface for purifying nucleic acids: The invention relates to spherical and magnetic silicagel particles which are provided with an increased surface by incorporating SiO2 colloids and produced by a method for inverse dispersion cross-linking of silica sols. The addition of certain metallic oxides to said silica sols and a subsequent tempering make it possible to... Agent: Davidson, Davidson & Kappel, LLC

20070087390 - Opiate, cannabinoid, and estrogen receptors: The present invention relates generally to mu3 opiate receptors, cannabinoid receptors, and estrogen surface receptors (ESRs). Specifically, the invention provides methods and materials for identifying mu3 opiate receptor agonists and antagonists, cannabinoid receptor agonists and antagonists, and ESR agonists and antagonists. In addition, the invention provides an isolated nucleic acid... Agent: Fish & Richardson P.C.

20070087391 - Optoelectronic sensor: A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070087394 - Epidermal growth factor receptor gene copy number: Methods of predicting whether an anti-epidermal growth factor receptor (“EGFr”)-specific binding agent treatment will be efficacious in treating cancer, and methods of treating patients with anti-EGFr-specific binding agents, are provided.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070087392 - Method for diagnosing head and neck squamous cell carcinoma: Disclosed are protein biomarkers and their use in diagnosing head and neck squamous cell carcinoma (HNSCC) or to make a negative diagnosis in patients. Also disclosed are kits for the diagnosis of HNSCC that detect the protein biomarkers of the invention, as well as methods using a plurality of classifiers... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070087393 - Quantitative zap-70 assay: An quantitative ZAP-70 assay is provided, with ZAP-70+ and ZAP-70− controls, normal human blood controls, an improved antibody with better signal to noise ratio, and using the median MEFL that is calibrated using a standard curve.... Agent: Tamsen Valoir, Ph.d. Baker & Mckenzie LLP

20070087395 - Method for detecting pathogenic organisms in fecal and salivary specimens and in biopsy material: The invention relates to a method for detecting pathogenic organisms, in particular Helicobacter pylori and H. heilmanii, in fecal, salivary and secretory samples by means of a double-antibody sandwich assay. The inventive method is characterized by dissolving or dispersing the sample having the pathogen antigen in a buffer solution and... Agent: Kirkpatrick & Lockhart Preston Gates Ellis LLP

20070087396 - Method of tacrolimus extraction and quantification