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Chemistry: molecular biology and microbiology March list of published pending patents 03/07

20070072166 - Semen preservation: The present invention provides a method for determining the suitability of a sample of mammalian semen for cooling and/or cryopreservation or storage, which comprises: (a) providing said sample of semen; (b) determining the level of a hydrophobic stimulator of 11β-HSD activity in said sample; and (c) assessing, from the level... Agent: Nixon & Vanderhye, PC

20070072172 - Liver specific chimeric regulatory sequence and use thereof: The present invention relates to a chimeric regulatory sequence with liver cell specificity. The chimeric regulatory sequence includes a proximal regulatory sequence and a distal enhancer 5 flanking region of human α-fetoprotein (AFP) gene. The chimeric regulatory sequence is useful in purified specific lineages, such as liver cells, from other... Agent: Bacon & Thomas, PLLC

20070072170 - Methods of determination of responsiveness to erythropoietin treatment: Methods for determining the responsiveness of a patient to recombinant human erythropoietin therapy are disclosed. In one approach, the method includes obtaining a volume-Hgb factor (VHf) defined as a product function of MCV and Hgb from a patient's blood sample; comparing VHf to a predetermined criterion; and reporting indication of... Agent: Beckman Coulter, Inc.

20070072168 - Microplate sample tracking system: The invention provides sample tracking systems and methods. A sample tracking system can comprise a plate having a plurality of sample wells and an apparatus for illuminating each individual sample well, wherein the manner with which the sample well is illuminated can track the loading of the sample components to... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070072169 - Process and apparatus for measuring binding events on a microarray of electrodes: There is disclosed a process and apparatus for reading electrical current of electrodes on a microarray of electrodes. Those electrodes having binding events are detected by a difference in electrical current flow. Enzymes on targets catalyze the conversion of substrate to product, which is detectable by electrochemical reduction at each... Agent: Combimatrix Corporation

20070072171 - Solid surface for biomolecule delivery and high-throughput assay: The present invention is related to a method for introducing biomolecules, such as nucleic acids, into cells by culturing cells on a solid surface which is coated with a transfection reagents and biomolecules.... Agent: Knobbe Martens Olson & Bear LLP

20070072167 - Tissue binding composition: The invention relates to a tissue binding composition. The inventive composition is characterised in that it comprises: between 40 g/l and 80 g/l trehalose, preferably approximately 60 g/l; between 40% and 80% (v/v) ethanol, preferably approximately 70% (v/v): between 0% and 5% (v/v) acetic acid, preferably approximately 1% (v/v); and... Agent: Foley And Lardner LLP Suite 500

20070072177 - Binding molecules capable of neutralizing rabies virus and uses thereof: The invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in... Agent: Trask Britt

20070072174 - Bioreporter for detection of microbes: A recombinant phage system has been developed for the rapid detection of bacteria, particularly fecal coliform indicator bacteria. The systems of the invention link phage infection events to quorum sensing signal molecule biosynthesis and bioluminescent bioreporter induction, facilitating the detection of pathogens that may be present in low numbers. The... Agent: Ruden, Mcclosky, Smith, Schuster & Russell, P.A.

20070072176 - Novel peptide compositions and their use in particular in the preparation of pharmaceutical compositions active against the hepatitis c virus: The invention relates to peptide compositions for use in the preparation of pharmaceutical compositions against hepatitis C virus, as well as corresponding methods.... Agent: Clark & Elbing LLP

20070072175 - Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof: This invention relates to a nucleotide array containing polynucleotide probes complementary to, or fragments of, Cynomolgus monkey genes, and the use of such a nucleotide array to characterize the biological effects, including the actions, targets, and toxicities, of therapeutic agents in primates, e.g., a human, a Cynomolgus monkey, or a... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.

20070072173 - Utilization of nucleotide probes in elisa procedure for the quantitative determination of baculovirus titer: To maximize the yield of protein from a baculovirus system, optimal infection of the host cell culture must be achieved; in order to obtain such optimal infection, the titer of the virus inoculation must be known. The present invention is the development of a simple, rapid, and universally applicable titration... Agent: Dr. Mai Nguyen Vista Biologicals Corporation

20070072225 - Antibodies with simultaneous subsite specificities to protein and lipid epitopes: Antibodies and method of making antibodies, either monoclonal or polyclonal wherein said antibodies have dual or multi-specific binding capacity to more than one type of antigenic epitope. The antibodies have simultaneous or independent recognition subsites to each of the epitopes. Antigenic epitopes include lipids, peptides, proteins, amino acid sequences, sugars... Agent: Caroline Nash Nash & Titus, LLC

20070072189 - Artificial mutation controls for diagnostic testing: Disclosed are artificial compositions that can be used as positive controls in a genetic testing assay, such as a diagnostic assay for a particular genetic disease. Such controls can be used to confirm the presence or absence of a particular mutation. Also provided are methods of generating such compositions, and... Agent: Klarquist Sparkman, LLP

20070072211 - Asymmetric pcr coupled with post-pcr characterization for the identification of nucleic acids: The present invention provides methods, compositions, and kits for quantification and identification of target nucleic acid sequences, either in pure solutions or from mixtures of various nucleic acids. In other aspects, the invention provides compositions and methods for HCV genotyping.... Agent: Roche Molecular Systems Inc Patent Law Department

20070072195 - Bio-commemorative article incorporating amplified genetic material: A combination of amplified genetic material from an individual or other organism with an inanimate article of manufacture to produce a bio-commemorative article is disclosed. The amplified genetic material is preferably produced from a polymerase chain reaction process. The amplified genetic material is coated onto the inanimate article of manufacture,... Agent: Rossi, Kimms & Mcdowell LLP.

20070072185 - Carbohydrate-binding modules of a new family: The present invention relates to non-catalytic carbohydrate-binding modules (CBM) belonging to a new family of CBM's. A CBM of the invention was found attached to a glycosyl hydrolase family 61 (GH61) polypeptide and was shown to have little homology with known CBM's indicating that it is the first known member... Agent: Novozymes North America, Inc.

20070072181 - Combination therapy for treating alphavirus infection and liver fibrosis: The present invention provides methods for treating alphavirus infections; methods of treating hepatitis C virus (HCV) infections; methods of treating West Nile virus infection; methods of reducing liver fibrosis; methods of increasing liver function in an individual suffering from liver fibrosis; methods of reducing the incidence of complications associated with... Agent: Bozicevic, Field & Francis LLP

20070072204 - Compositions and methods for cancer diagnosis and treatment: The application relates to methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the mir17-92 cluster. The application further relates to screening methods to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070072223 - Compositions and methods for purifying nucleic acids: Described herein are compositions and methods for enriching a nucleic acid sample for target sequence(s). The compositions comprise an oligonucleotide attached to a solid support, directly or indirectly, wherein the oligonucleotide does not serve as a primer for a polymerase enzyme.... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070072230 - Compositions, kits, and methods relating to the human fez1 gene, a novel tumor suppressor gene: The invention relates to isolated polynucleotides homologous with a portion of one strand of the human tumor suppressor gene, FEZ1, and to the tumor suppressor protein encoded thereby, Fez1. The polynucleotides are useful, for example, as probes, primers, portions of expression vectors, and the like. The invention also includes diagnostic,... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070072199 - Covalent methods for immobilization of thiolated biomolecules on siliceous and metallic surfaces: The present invention is directed to methods for immobilizing molecules on siliceous and metallic surfaces. Molecules are immobilized on siliceous or metallic surfaces by stable covalent linkages that are capable of withstanding prolonged use and elevated temperatures. Further, the methods of the present invention describe less-complicated chemistries for the immobilization... Agent: Wilmerhale/columbia University

20070072219 - Detection method of homologous sequences differing by one base on a microarray: The present invention is related to a detection method and kit of homologous sequences differing by one base on a microarray.... Agent: Knobbe Martens Olson & Bear LLP

20070072214 - Detection of truncation mutations by mass spectrometry: This invention relates to the detection and analysis by mass spec of nascent proteins, and in particular truncated proteins, translated within cellular or cell-free translation systems. N-terminal and C-terminal epitopes introduced into these nascent proteins permit rapid and efficient isolation, as well as a mass difference.... Agent: Medlen & Carroll, LLP

20070072224 - Diagnosis and treatment of tumor-suppressor associated disorders: Methods are provided for detecting a cell proliferative disorder associated with TSLC1 by contacting a proliferating cell of a subject suspected of having the disorder with a reagent that detects TSLC1 and detecting the level of TSLC1 in the proliferating cell. TSLC1 is a single gene whose expression is reduced... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP

20070072228 - Ercc2 polymorphisms: This invention relates to diagnostic methods based upon a polymorphism in individuals indicative of an increased risk of breast carcinoma. More specifically, this invention relates to a method for diagnosis of an increased risk of breast carcinoma by screening for the presence of genetic polymorphisms in individuals, specifically in the... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20070072222 - Fabp4 as biomarker for toxic effect: The present invention relates to FABP4 as a marker for determining at least one toxic effect of a compound of interest and methods for determining same.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20070072196 - Fluorescent nucleotide analogs and uses therefor: Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others.... Agent: Pacific Biosciences Of California, Inc.

20070072227 - Gamma secretase notch biomarkers: The present invention relates to biomarker indicators, including polypeptides, polynucleotides and small molecules, that measure γ-secretase mediated Notch processing. These indicators have utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The reagents and methods of the invention can be utilized... Agent: Louis J. Wille Bristol-myers Squibb Company

20070072194 - Global transcription machinery engineering: The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes.... Agent: Wolf Greenfield & Sacks, PC

20070072232 - Identification of genetic components of drug response: The present invention is concerned generally with the field of identifying an appropriate treatment regimen for a disease based upon genotype in mammals, particularly in humans. It is further concerned with the genetic basis of inter-patient variation in response to therapy, including drug therapy. Specifically, this invention describes the identification... Agent: Nuvelo, Inc

20070072191 - Infectious pestivirus pseudo-particles containing functional erns, e1, e2 envelope proteins: The invention relates to the generation and the use of pestivirus pseudo-particles containing native functional E1, E2 envelope glycoproteins assembled onto retroviral core particles. These particles are highly infectious and constitute a valid model of pestivirus virion.... Agent: Stites & Harbison PLLC

20070072193 - Ligand arrays having controlled feature size, and methods of making and using the same: Methods and compositions for producing a solid support having a ligand immobilized on a surface thereof, e.g. a ligand array, are provided. Aspects of the methods include: providing a solid support having a bounded feature location on a surface thereof, where the bounded feature location includes a region of the... Agent: Agilent Technologies Inc.

20070072213 - Method and apparatus for implementing non-destructive quality control of substrates and printed biological microarrays, and for implementing quality control and visualizing gel-based microarrays prepared by dispensing gel-forming composition on solid surf: A method and apparatus are provided for implementing non-destructive quality control of substrates and printed biological microarrays. A method and apparatus are provided for implementing quality control of gel-based microarrays prepared by dispensing a gel-forming composition on a solid substrate. The method utilizes the difference between the wettability properties of... Agent: Joan Pennington

20070072200 - Method for determining co-receptor selectivity of human immunodeficiency virus-1: Newly discovered structural characteristic of the gp120 V3 loop have resulted in a “rule” or algorithm, that is used in a method for determining whether a subject is infected with HIV-1 virus that expresses selectivity for CXCR4 or CCR5 chemokine receptors. A positively charged surface patch defined by V3 loop... Agent: Mckenna Long & Aldridge LLP

20070072216 - Method for diagnosis of glioma: distinguishging between progressive and de novo types: The present invention relates to a method for identifying the type of glioblastoma multiforme in mammals, preferably human subjects. More particularly, it relates to a kit for characterizing progressive glioma in mammals, preferably human subjects. More particularly, it relates to a kit for distinguishing primary and secondary glioblastoma multiforme (GBM)... Agent: Brinks Hofer Gilson & Lione

20070072229 - Method for isolation, amplification and quantitation of ribonucleic acid: A cellular RNA isolation method comprising treating at least one nucleated cell with a composition comprising mild detergents such as non-ionic detergent(s), buffer(s), chelator(s), reducing agent(s), salt(s), and RNase inhibitor(s) to result in a cytoplasmic lysate and intact nucleus, then separating the cytoplasmic lysate containing RNA from the nucleus, and... Agent: Wood, Herron & Evans, LLP

20070072201 - Method for producing improved nucleic acid oligomer functional homogeneity and functional characteristic information and results and oligomer application results: An approach and methods are provided for obtaining improved information and results concerning the functional homogeneity and functional characteristics of a chemically synthesized or biologically synthesized nucleic acid oligomer of any type, and for obtaining improved information and results concerning the functional homogeneity and functional characteristics of the oligomer under... Agent: Wesley B. Ames

20070072186 - Methods and agents for screening for compounds capable of modulating her2 expression: The invention relates to the fields of screening assays and compounds and methods for altering protein expression and levels of protein. In particular, the invention includes assays to screen for agents capable of modulating expression of Her2 and agents capable of modulating Her2 expression.... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20070072233 - Methods and systems for facilitating the diagnosis and treatment of schizophrenia: A method of diagnosing, assessing susceptibility, and/or treating schizophrenia involving the observation of regulator of G-protein signaling 4 (RGS4) levels in a subject. Embodiments of the present invention include increasing RGS4 expression levels in the cortex, either by chemical means or by genetic complementation (e.g. gene therapy).... Agent: Reed Smith LLP

20070072182 - Methods for amplification of nucleic acid sequences using staggered ligation: Methods and kits are provided for producing sense RNA molecules. The sense RNA molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20070072188 - Methods for detection of mycobacterium tuberculosis: The present invention provides an oligonucleotide primer pair having SEQ ID NO: 3 and SEQ ID NO: 4 for amplification of Early Secretory Antigenic Target (esat)-6-gene of Mycobacterium species. The invention also provides a method for detecting M .tuberculosis in a sample based on the amplification of esat-6 gene, comprising... Agent: Birch Stewart Kolasch & Birch

20070072203 - Methods for drug discovery, disease treatment, and diagnosis using metabolomics: The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.... Agent: Lahive & Cockfield, LLP

20070072209 - Methods of treatment and diagnosis of kaposi's sarcoma (ks) and ks related diseases: Aspects of the present invention use gene expression profiling, and gene silencing methods to identify and provide a plurality of ‘validated’ KSHV-induced cellular gene sequences and pathways useful as targets for modulation of KSHV-mediated effects on cellular proliferation and phenotype (e.g., cancer) associated with latent and lytic phases of the... Agent: Davis Wright Tremaine, LLP

20070072221 - Methods to screen peptide display libraries using minicell display: A minicell display method has been developed which has significant advantages for screening peptide libraries for candidates that can bind and effectively modulate a particular biological process. The method, based on the small, anucleate minicell, has increased versatility in generating unique sequences to screen as well as increasing the size... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070072197 - Microtags for detection and identification of materials: A customized microtag identifier has a custom synthesized polynucleic acid having a known sequence of bases, a recovery compound, and a protective coat; effective to identify said custom synthesized polynucleic acid,... Agent: Naval Surface Warfare Center, Dahlgren Division Office Of Counsel, Code Xdc1

20070072226 - Mining protein interaction networks: One embodiment is a method including creating a protein interaction network including a plurality of protein IDs and a plurality of interactions between protein IDs, determining confidences of interactions of the protein interaction network, identifying a sub-network of the protein interaction network, and determining relevance of proteins of the sub-network... Agent: Krieg Devault LLP

20070072198 - Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes: The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.... Agent: Joseph C. Zucchero

20070072180 - Mutations in nod2 are associated with fibrostenosing disease in patients with crohn's disease: The present invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease characterized by fibrostenosing disease by determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of... Agent: Davis Wright Tremaine LLP

20070072205 - Nanomaterial error correction: The present invention makes use of the discovery that proofreading and error-correction techniques common in biological systems may be adapted to material science. Enzymes and aptamers are adapted to proofread and correct defects in nanoparticle structures.... Agent: Evan Law Group LLC

20070072220 - Non-fouling polymeric surface modification and signal amplification method for biomolecular detection: An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a polymer layer comprising brush molecules formed on the linking layer; and (d) optionally but preferably, a first... Agent: Myers Bigel Sibley & Sajovec

20070072178 - Novel genetic markers for leukemias: The present invention is related to methods for detecting leukemia cells by determining the expression profile of a group of markers. In particular, the type or subtype of leukemia cells in a sample is determined. Further, uses of the group of markers is discloses and compositions comprising these markers.... Agent: Quine Intellectual Property Law Group, P.C.

20070072187 - Novel methods and apparatus for cell based microarray assays: The present invention relates methods for screening of cellular responses comprising: (a) providing a solid porous support having first and second surfaces and at least one area with a plurality of through-going channels (b) providing cellular components on said first and/or second surface of said solid porous support, wherein said... Agent: Amster, Rothstein & Ebenstein LLP

20070072192 - Novel polypeptides encoded by essential bacterial genes: The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070072208 - Nucleic acid analysis by random mixtures of non-overlapping fragments: The invention provides methods and kits for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fragments in a final level or tier. Each fragment in such... Agent: Stephen C. Macevicz C/o Chief Financial Officer

20070072215 - Nucleic acid-based logic circuits: This invention relates to nucleic acid-based logic gates. The invention further relates to circuits comprising nucleic acid-based logic gates and methods of performing operations with the gates and circuits provided herein.... Agent: Buchanan, Ingersoll & Rooney LLP

20070072207 - Production of vaccines: Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removing the virus-containing... Agent: Trask Britt

20070072179 - Solid-phase assisted spectroscopic and spectrometric analysis of complex biopolymer mixtures: The present invention relates to a method and kit for analyzing complex mixtures of biopolymers from one or more samples.... Agent: Needle & Rosenberg, P.C.

20070072206 - Strong pcr primers and primer cocktails: The invention disclosed relates to a PCR primer pair for amplication of chaperonin-60 (cpn60) targets having high G+C content and to a PCR primer “cocktail” to improve the representation of diverse sequences in chaperonin-60 based PCR product libraries derived from complex templates. In previous cpn60-based and 16S rDNA-based studies of... Agent: Ade & Company Inc.

20070072184 - Susceptibility gene for alzheimer's disease: The invention relates to genetic screens for susceptibility to Alzheimer's disease. In particular, the invention provides genetic screens based on genotyping of the p21E2c31 polymorphism and/or the p21E3+20 C/T polymorphism in the p21cip 1 gene.... Agent: Synnestvedt & Lechner, LLP

20070072190 - System and method for universal identification of biological humans: A system and method for uniquely identifying each human being and generate a Universal Identification Number (UIN) to aid tracking. UIN database comprises of public, health, and confidential information. The number issued for display on UIN Identity Card and used for accessing data on-line protects privacy of the individual by... Agent: Dr. Abhinav Aggarwal

20070072183 - Topoisomerase hybrids and methods of use: The present invention provides hybrid topoisomerases, methods for assaying topoisomerase activity, methods for identifying compounds that modulate topoisomerase activity, and methods for identifying antibacterial agents.... Agent: Astrazeneca R&d Boston

20070072231 - Tumor suppressor gene: A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells... Agent: Fish & Richardson PC

20070072218 - Tumor suppressor killin: The present invention relates to a new tumor suppressor, designated Killin. Also described are diagnostic and therapeutic uses of the Killin protein and the killin gene, alone or in combination with traditional cancer therapies.... Agent: Fulbright & Jaworski L.L.P.

20070072210 - Use of brca1-associated protein to treat and screen for dna damage and to identify therapeutics that promote a dna damage response: The present invention relates to the use of a BAAT1 protein to screen for potential therapeutics that promote a DNA damage response or treat breast cancer. The present invention also relates to a method of treating DNA damage or breast cancer in a subject by administering a compound that increases... Agent: Nixon Peabody LLP - Patent Group

20070072202 - Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors: The present invention provides novel materials and screening methods for identifying agonists and antagonists of cell receptors. Methods are disclosed for identifying agonists and antagonists using chimeric receptors comprising the extracellular ligand-binding domain of a first receptor fused with the transmembrane and intracellular domains of a second receptor containing an... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070072212 - Use of markers including nucleotide sequence based codes to monitor methods of detection and identification of genetic material: The use of artificially-generated nucleic acid coded markers to monitor nucleic acid amplification and sequencing reactions designed to detect or analyze biological samples. The markers generally include, along with a unique sequence preferably including coded section designed to represent one or more factors of interest, primer annealing sequences so that... Agent: Kirby Eades Gale Baker

20070072217 - Xaf genes and polypeptides: methods and reagents for modulating apoptosis: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.... Agent: Philip Swain, Phd C/o Gowling Lafleur Henderson

20070072241 - Diagnostic methods for age related macular degeneration: Diagnostic methods for identifying a test subject who has or is at risk of developing age-related macular degeneration (AMD) or an analogous disease associated with oxidation of DHA-containing lipids are provided. In one aspect, the methods comprise: assaying for the presence of elevated levels of 2-(ω-carboxyethyl) pyrrole (CEP) adducts in... Agent: Calfee Halter & Griswold, LLP

20070072242 - Immunoassay method and kit to leucomalachite green and malachite green: The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as, antibodies raised against such immunogens and capable of binding with leucomalachite green and malachite green.... Agent: Woodcock Washburn LLP

20070072240 - Method for producing an in vitro expression library: The present invention relates to an antibody expression library derived from a patient which has been immunochallenged with one or more foreign antigens associated with a particular disease or foreign agent, wherein said patients have been immunochallenged with the foreign antigens at a time point such that they still contain... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070072237 - Method of assessing rheumatoid arthritis by measuring rheumatoid factor and interleukin-6: The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of RF and interleukin-6... Agent: Roche Diagnostics Operations Inc.

20070072236 - Novel type ii na/pi cotransporters and type ii na/pi cotransporter expression regulatory factors: The present invention provides novel type IIc Na/Pi cotransporters. These cotransporters are important Pi transporters that are highly expressed during the growth period from the weaning stage to the adult stage. Furthermore, the present invention provides FGF23 and mutants thereof as factors that regulate the expression of type II Na/Pi... Agent: Fish & Richardson PC

20070072239 - Pharmaceutical compositions and methods of using secreted frizzled related protein: Methods and pharmaceutical compositions of use in regulation of mammalian bone-forming activities of SFRPs (secreted frizzled-related proteins) are disclosed. SFRPs are secreted receptors for Wnts, which are important polypeptide growth factors that are known to regulate fundamental biological processes such as tissue polarity, embryonic development, and tumorigenesis. Methods can be... Agent: Darby & Darby P.C.

20070072234 - Protein capable of binding plasticizer: The present invention provides a protein having a binding capacity to a plasticizer, which has been conferred with useful properties for measuring, quantifying, or concentrating a plasticizer, such as high sensitivity, low cross-reactivity, high tolerance for interferents, and high tolerance for solvents. Specifically, the present invention provides a modified protein... Agent: Edwards & Angell, LLP

20070072235 - Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways: The invention discloses 211 novel phosphorylation sites identified in signal transduction proteins and pathways underlying Anaplastic Large Cell Lymphoma (ALCL) involving the ALK-NPM translocation/fusion, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of... Agent: James Gregory Cullem, Esq. Intellectual Property Counsel

20070072238 - Wnt-frizzled chimera: The present invention relates to a Wnt-Frizzled chimera. The present invention also relates to pharmaceutical compositions that can be screened or developed using Wnt-Frizzled chimeras. The methods and pharmaceutical compositions of the present invention can be used to treat bone disorders and cancer.... Agent: Darby & Darby P.C.

20070072246 - Cell-based assays for determining drug action: Compositions and methods are provided for the classification of biologically active agents according to their effect on human biology, through the use of complex, primary human cell-based disease models in scalable assay formats. The systems of the invention utilize the simultaneous activation of multiple signaling pathways to generate and identify... Agent: Bozicevic, Field & Francis LLP

20070072248 - Constitutively activated human g protein coupled receptors: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown (“orphan GPCR receptors”), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.... Agent: Cozen O'connor, P.C.

20070072249 - Human cytokine and alpha-helix-containing polypeptides: This invention relates to new human alpha-helix-containing polypeptides, to methods of making such polypeptides, to methods of using them to treat immunological conditions, and to methods of identifying compounds that alter alpha-helix-containing polypeptide activities.... Agent: Immunex Corporation Law Department

20070072245 - Method and means for the determination of defined states or modifications in the mucus of the uterus or in the epithelium of other organs: The invention relates to a method and means for the determination of defined states or modifications in the mucus of the uterus or in the epithelium of other organs, especially for the diagnosis of pregnancy and diagnosis of embryo-implantation. In a biological sample, the concentration of human endometrial chorionic gonadotropin... Agent: Gudrun E. Huckett Draudt

20070072247 - Methods and reagents for the analysis and purification of polysaccharides: The disclosure provides fusion proteins comprising a carbohydrate recognition domain of an innate immunity receptor and a heterologous polypeptide. The fusion proteins of the disclosure may be used, for example, to fingerprint polysaccharide compositions and to purify polysaccharide compositions. Polysaccharide compositions include those isolated from Ganoderma lucidum (Reishi). The methods... Agent: Greenberg Traurig LLP

20070072243 - Multiplex screening for lysosomal sotrage disorders (lsds): A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against... Agent: Jackson Walker LLP

20070072244 - Use of the endo-180 gene and polypeptide for diagnosis and treatment: This application is directed to a process of identifying a compound capable of modulating activity of a human ENDO180 receptor that comprises the steps of measuring the binding of the ENDO180 receptor to an interactor with which the ENDO180 receptor interacts specifically in vivo, in the absence or presence of... Agent: Cooper & Dunham, LLP

20070072251 - In vivo imaging using peptide derivatives: The present invention relates to the use of phage display LLG peptide derivatives as tumor targeting agents for diagnostic purposes, and to a method for targeting and imaging tumors and infections/inflammation. A diagnostic composition comprising said peptide derivatives is also disclosed.... Agent: Birch Stewart Kolasch & Birch

20070072250 - Method and system for analysis of cancer biomarkers using proteome image mining: The present invention provide a system and a method for detection of cancer, by producing a serum proteome standard by an image mining technique, and provide cancer-specific biomarkers. Disclosed is a method of analyzing cancer, comprising the steps of transforming serum proteomes from normal individuals and individuals having cancer into... Agent: Tanya A Arenson Medlen & Carroll

20070072252 - Method for the in vitro titration of an ncta application thereof in a method for the evaluation and/or monitoring of a biological product production method: The invention relates to a method for the in vitro titration of a non-conventional transmissible agent (NCTA), using transgenic cell lines. The invention also relates to: the application of the aforementioned in vitro titration method in a method for the in vitro evaluation and/or monitoring of the effectiveness of a... Agent: Birch Stewart Kolasch & Birch

20070072253 - Method of determining standard activity value of nattokinase: A method of determining a standard activity value of Nattokinase includes preparing a standard curve with respect to a plurality of Nattokinases having predetermined activity values by calculating corresponding dilution multiples using a standard essay, obtaining a sample curve with respect to an indeterminate Nattokinase by diluting the indeterminate Nattokinase... Agent: Hdsl

20070072254 - Manufacture of vitamin b6: A process for manufacturing a 3-unsubstituted, 3-monosubstituted or 3,3-disubstituted 9-acyloxy-1,5-dihydro-8-methylpyrido[3,4-e] [1,3]dioxepin (I) and optionally for manufacturing pyridoxine involves performing an addition reaction between a 4-methyl-5-alkoxy-oxazole (II) and a 2-unsubstituted, 2-monosubstituted or 2,2-disubstituted 4,7-dihydro-(1,3)-dioxepin (III) in the substantial absence of a solvent and a catalyst to give a product mixture consisting... Agent: Nixon & Vanderhye, PC

20070072256 - Optical molecular sensors for cytochrome p450 activity: The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the invention is a compound having the... Agent: Invitrogen Corporation C/o Intellevate

20070072255 - Toxicity detector for liquid consumable by humans: A process provides for testing for certain toxins and poisons in liquids, gases and solids that are consumed by humans or otherwise come in contact with humans. In the process, the material to be tested is mixed with aerobic microorganisms in a biomass to form a mixture. The mixture is... Agent: John C. Mcmahon

20070072257 - Multiwell plate assembly for use in high throughput assays: A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can... Agent: Knobbe Martens Olson & Bear LLP

20070072258 - Ultrasound-mediated high-speed biological reaction and tissue processing: Methods of fixing and processing tissue and samples on a membrane by using ultrasound radiation as a part of the method are presented. Ultrasound of a frequency in the range of 0.1-50 MHz is used and the sample or tissue receives 0.1-200 W/cm2 of ultrasound intensity. The use of ultrasound... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070072262 - Arg1, arg2, arg3, his1, his2, his5, his6 genes and methods for stable genetic integration: Novel genes encoding P. pastoris ARG1, ARG2, ARG3, HIS1, HIS2, HIS5 and HIS6 are disclosed. A method for inactivating alternately at least two biosynthetic pathways in a methylotrophic yeast is provided. A method for producing and selecting yeast strains characterized as being capable of genetic stable integration of heterologous sequences... Agent: Chang B. Hong

20070072260 - C1q related protein: This invention relates to the novel protein, termed INSP163, herein identified as a secreted protein containing a jelly-roll fold, in particular, as a member of the TNF (tumor necrosis factor)-like family of cytokines, specifically as a C1q-like protein and to the use of this protein and nucleic acid sequence from... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070072265 - Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070072263 - Dna19355 polypeptide, a tumor necrosis factor homolog: A tumor necrosis factor homolog, identified as DNA19355, is provided. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided.... Agent: Genentech, Inc.

20070072259 - Fluorescent protein: An object of the present invention is to provide a novel fluorescent protein derived from favia favus. The present invention provides a fluorescent protein derived from favia favus having the following properties: (1) an excitation maximum wavelength is 507 nm; (2) a fluorescence maximum wavelength is 517 nm; (3) a... Agent: Greenblum & Bernstein, P.L.C

20070072261 - Nucleic acids encoding pak5 polypeptidesm and methods of use thereof: The present invention relates to the nucleic acid molecules encoding an STE20-related family of novel protein kinases, ZC1, ZC2, ZC3, ZC4, STLK2, STLK3, STLK4, STLK5, STLK6, STLK7, KHS2, SULU1, SULU3, GEK2, PAK4 and PAK5, segments and domains thereof, as well as various methods useful for the diagnosis and treatment of... Agent: Foley And Lardner LLP Suite 500

20070072270 - Polypeptide: We disclose a PS4 variant polypeptide derivable from a parent polypeptide, the parent polypeptide having non-maltogenic exoamylase activity, which PS4 variant polypeptide comprises one or more of the following substitutions: G69P, A141P, G223A, A268P, G313P, S399P and G400P, with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence... Agent: Steptoe & Johnson LLP

20070072264 - Recombinant chimeric acetylcholine receptors and their derivatives recognized by cd4 t cells of myasthenic patients for the treatment of myasthenia gravis: The present invention relates to recombinant acetylcholine receptor polypeptides recognized by CD4 T cells of a myasthenia gravis patient and compositions for the treatment of myasthenia gravis containing the same as an effective ingredient, more precisely, recombinant acetylcholine receptor polypeptides deficient in B cell epitope, recombinant acetylcholine polypeptides in which... Agent: Joseph Hyosuk Kim, Ph.d. Jhk Law

20070072266 - Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof. therapeutic uses thereof: The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070072268 - Sulfotransferase and dna encoding the enzyme: A glycosaminoglycan 6-O-sulfotransferase having an activity of transferring sulfate to a hydroxyl at position 6 of a glycosamine residue of a glycosaminoglycan, which has a ratio of relative activities to substrates satisfying completely desulfated N-acetylated (CDSNAc) heparin/completely desulfated N-resulfated (CDSNS) heparin ≧0.05 and a molecular weight as calculated from constituent... Agent: Knobbe Martens Olson & Bear LLP

20070072267 - Transformant having galactose induction system and use thereof: The present invention provides a transformant having a gene expression inducing system having better responsiveness. The transformant of the invention has a galactose induction system and retains a coding region having a galactose induction system and encoding an assisting protein assisting transcription activation by a protein having the Gal4 activity... Agent: Oliff & Berridge, PLC

20070072269 - Ubiquitin-specific protease occurring in the brain and dna encoding the same: A ubiquitin-specific protease occurring in the brain and a DNA encoding it, which are useful for research on the molecular mechanism of the neuroplasticity expression and so on.... Agent: Choate, Hall & Stewart LLP

20070072271 - Method for the production of recombinant proteins: The present invention relates to a process for the production of recombinant polypeptides in leukocytes.... Agent: Novo Nordisk, Inc. Patent Department

20070072272 - Industrial method for producing rna and system for carrying out said method: The invention relates to an industrial method for producing an interest heterologous RNA and to a system for carrying out said production method consisting (1) in transforming mitochondrions of yeast cells free of mitochondrial RNA with a mitochondrial transcription vector comprising at least one copy of the DNA encoding said... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070072274 - Genes coding for metabolic pathway proteins: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.... Agent: Lahive & Cockfield, LLP

20070072273 - Genes encoding genetic stability, gene expression and folding proteins: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.... Agent: Lahive & Cockfield, LLP

20070072275 - Method for breeding lipid-producing fungus: It is intended to provide a breeding method whereby a lipid-producing fungus belonging to the genus Mortierella can be effectively and efficiently bred without resort to antibiotics. Transformation is carried out with the use of an auxotroph (for example, uracil auxotroph) of a fungus belonging to the Mortierella as a... Agent: Harness, Dickey & Pierce, P.L.C

20070072276 - Method for separating, extracting and purifying poly-beta-hydroxyalkanoates (phas) directly from bacterial fermentation broth: The invention discloses a method for directly separating and purifying polyhydroxyalkanoates in cells from fermentation liquid and it relates to the field of posttreatment technology of biological engineering. The method includes following steps: pretreating fermentation liquid with physical method for breaking cell wall; adjusting pH value of pretreated fermentation liquid... Agent: Butzel Long

20070072277 - Process for producing glutamate derivatives: The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070072278 - Reductase gene and use thereof: Provided are genes coding a protein having an ability of asymmetrically reducing a 2-oxo-4-phenylbutyrate to produce a (R)-2-hydroxy-4-phenylbutyrate advantageously from the industrial standpoint, the protein, and methods of producing a (R)-2-hydroxy-4-phenylbutyrate using them. Genes having a base sequence coding an amino acid sequence shown in SEQ ID NO:1, or a... Agent: Akin Gump Strauss Hauer & Feld L.L.P.

20070072279 - Evolved micro-organisms for the production of 1,2-propanediol: The present invention concerns a new method of preparation of a strain of evolved micro-organisms for the production of 1,2-propanediol by the metabolism of a simple carbon source, which method comprises the growth under selection pressure in an appropriate growth medium containing a simple carbon source of an initial bacterial... Agent: Dorsey & Whitney LLP Intellectual Property Department

20070072280 - Materials and methods for the efficient production of xylitol: Novel microorganisms are provided that efficiently convert xylose (or xylulose) alone or in combination with a carbon substrate to produce xylitol. In certain embodiments, E. coli are engineered to include a mutant crp gene as well as deletion of the xylB gene. The microorganisms of the invention are particularly advantageous... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070072281 - Three-dimensional structure of the catalytic domain of protein kinase c theta, methods and uses thereof: The present invention concerns protein kinase C (PKC) theta, in particular, the three-dimensional structure of the catalytic domain of PKC theta. Methods of expression, purification and crystallization of PKC theta catalytic domain are provided in preparation for crystallography. The atomic coordinates of a complex of PKC theta complexed with an... Agent: Novartis Corporate Intellectual Property

20070072282 - Bovine adeno-associated viral (baav) vector and uses thereof: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.... Agent: National Institute Of Health C/o Needle & Rosenberg, P.C.

20070072283 - Nitrite-type nitrification carrier and method for producing the same and method and apparatus for removing nitrogen using the same: Provided are a nitrite-type nitrification carrier and a method for producing the same and a method and an apparatus for removing nitrogen using the same, in which the quantity of organic matter to be added can be substantially reduced to reduce running cost. A method for producing a nitrite-type nitrification... Agent: Oliff & Berridge, PLC

20070072284 - Nitrite-type nitrification carrier and method for producing the same and method and apparatus for removing nitrogen using the same: Provided are a nitrite-type nitrification carrier and a method for producing the same and a method and an apparatus for removing nitrogen using the same, in which the quantity of organic matter to be added can be substantially reduced to reduce running cost. A method for producing a nitrite-type nitrification... Agent: Oliff & Berridge, PLC

20070072285 - Fluid interface for bioprocessor systems: An apparatus and method for an aseptic fluidic interface between bioprocess systems is provided. The apparatus includes an inlet valve, adapted for automatic control, that is coupled to a biofluid source site. A sampling conduit extends from the inlet valve to an outlet valve. The outlet valve is adapted for... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070072287 - Biomems cartridges: A cartridge includes a first layer to receive a printed circuit board hosting a biochip. A second layer is connected to the first layer and is configured for sample injection to the biochip. The second layer includes a first septum to isolate fluidic ports. A third layer is connected to... Agent: Cooley Godward Kronish LLP

20070072286 - Label-free detection of biomolecules: The invention provides a method and a device for label-free detection of biomolecules or analytes in a sample liquid. The method comprises the steps of allowing an analyte to bind to one of at least two conductive surfaces. An alternating electrical field between at least two conductive surfaces. Amplitude and... Agent: Philips Intellectual Property & Standards

20070072288 - Cell culture apparatus and a fabricating method of the same: A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of:2-hydroxyethylmathacrylate(HEMA),bisphenolA... Agent: Bacon & Thomas, PLLC

20070072289 - Application apparatus of 3-dimensional klinostat and growing method using the same: In an application apparatus of a klinostat, an object is encapsulated in a vessel. A rotating unit rotates the vessel around n axes (n is an integer more than 1) such that gravity is equally applied to the object. A fluid supply unit supplies fluid into the vessel, while the... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070072290 - Microstructure for particle and cell separation, identification, sorting, and manipulation: The invention relates to microscale cell separating apparatus which are able to separate cells on the basis of size of the cells, interaction of the cells with surfaces of the apparatus, or both. The apparatus comprises a stepped or sloped separation element (16) interposed between an inlet region (20) and... Agent: Duane Morris, LLPIPDepartment

20070072291 - Dedifferentiated, programmable stem cells of monocytic origin, and their production and use: The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for... Agent: David R. Marsh Arnold & Porter

20070072292 - Epha4-positive human adult pancreatic endocrine progenitor cells: The invention relates to the discovery of a selective cell surface marker that permits the selection of a unique subset of pancreatic stem cells having a high propensity to differentiate into insulin-producing cells or into insulin-producing cell aggregates.... Agent: Townsend And Townsend And Crew, LLP

20070072293 - Process for stabilization of bacterial cells: Biocompatible medium and non-ionic polymer surfactants such as tyloxapol may be used in a composition for preserving cells, such as bacterial cells. Cells may be preserved, for example, by suspending them in a biocompatible medium containing tyloxaopol and preserving the suspension. Examples of a preservation procedure are drying by foam... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070072294 - Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division: A method for treating a subject afflicted with a cardiac disorder, in vivo, comprising (i) producing a solution comprising media conditioned from the culture of cells, in vitro, and (ii) administering the solution of step (i) to the subject, thereby treating the cardiac disorder in the subject. Methods for determining... Agent: Kenyon & Kenyon LLP

20070072295 - Multipotent lymphohematopoietic progenitor cells: This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to... Agent: Quarles & Brady LLP

20070072296 - C/ebpalpha gene targeting constructs and uses thereof: A DNA construct for the expression of a functional mammalian C/EBPα comprising the following components: (i) a first region having homology with an endogenous tumor-specific promoter gene sequence of a gene locus (ii) a DNA molecule encoding the C/EBPα; and (iii) a second region having homology with a region within... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070072297 - Method for ligating nucleic acids and molecular cloning: The invention provides methods of covalently joining nucleic acid molecules and methods of molecular cloning. The methods provide either sequential or simultaneous ligation of flanking or vector nucleic acid molecules to nucleic acid insert molecules by topoisomerase and DNA ligase. The methods provide for directional and non-directional covalent joining and... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070065805 - Cell migration assay: The present invention provides compositions and methods for preparation of a three-dimensional transendothelial cell migration (TEM) assay. These compositions and methods are uniquely suited for the high throughput TEM assay, and for the analysis and identification of TEM mediators which inhibit or stimulate this process. The composition for detecting migration... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070065801 - Diagnostics and therapeutics for diseases associated with 5-hydroxytryptamine (seotonin) receptor 4 (5-ht4): The invention provides a human 5-HT4 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver... Agent: Banner & Witcoff

20070065806 - Gel spot picker: The present invention relates to a gel sheet (1) for use in a spot picker device wherein said gel sheet is provide with reference marks (5′-5′″) which can be used to determine if the gel sheet (1) has been deformed between the stages of scanning the gel sheet and picking... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070065808 - Method and apparatus for sorting particles: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing... Agent: Lahive & Cockfield, LLP

20070065802 - Method and system for measuring the penetration of drugs and other substances into tissue: The failure of many anticancer drugs to control growth of solid cancers may stem in part from inadequate delivery to tumor regions distant from vasculature. However, extricating the effect of tissue penetration from the many other factors that affect a drug's efficacy in tumors with distance from vasculature is generally... Agent: Oyen, Wiggs, Green & Mutala LLP 480 - The Station

20070065804 - Method for pr-39 peptide mediated selective inhibition of ikappabalpha degradation: The present invention provides both a method and means for regulating IκBα degradation, NFκB activity, and NFκB-dependent gene expression within living cells, tissues, and organs in-situ. The selective regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for interaction with such IκBα and proteasomes as are... Agent: Licata & Tyrrell P.C.

20070065807 - Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same: The object of the present invention is to provide the following: a method for preparing a basement membrane which is extracellular matrices having a function to control morphology, differentiation, proliferation, motility, function expression and the like of cells; a method for constructing a specimen of a basement membrane; a process... Agent: Frommer Lawrence & Haug

20070065803 - Patterns for a skeletal system: The present invention relates to a bone system model comprising a mineralized matrix and osteoblasts, chararacterized in that the osteoblasts are deposited onto the matrix so as to form a layer at confluence and/or nodules, and the osteoclasts are deposited onto said layer and/or said nodules, and also to bone... Agent: Buchanan, Ingersoll & Rooney PC

20070065813 - Assay for quantitative detection of respiratory syncytial virus (rsv): The present invention describes respiratory syncytial virus (RSV) primers and probes as reagents for detection of a RSV infection. Specifically, the invention provides nucleic acid sequences from the RSV nucleocapsid gene used with hybridization and PCR techniques to detect RSV infection.... Agent: Licata & Tyrrell P.C.

20070065809 - Compositions and methods screening using populations of surrogate antibodies: Methods and compositions for the detection, identification, and quantification of compounds of interest in a sample are provided. The compositions and methods include arrays and kits comprising a population of surrogate antibodies that bind compounds of interest. The surrogate antibodies can be immobilized on to a solid support by means... Agent: Alston & Bird LLP

20070065814 - Detecting foot-and-mouth disease virus: This document relates to methods and materials involved in determining whether or not an animal contains a foot-and-mouth disease virus. For example, nucleic acid primer pairs, combinations of nucleic acid primer pairs, nucleic acid arrays (e.g., diagnostic cards) containing nucleic acid primer pairs or combinations of nucleic acid primer pairs,... Agent: Fish & Richardson P.C.

20070065810 - Diagnosis and treatment of cervical cancer: In certain aspects, the invention relates to methods of diagnosing cervical cancer by using a combination of certain biomarkers such as hTERT, IGFBP-3, transferrin receptor, beta-catenin, Myc-HPV E6 interaction, HPV E7, and telomere length. In other aspects, the invention relates to methods of detecting immortalization of cervical cells by using... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070065811 - Method of detecting multiple analytes: The invention relates to a a microtiter plate and its use in a method of the invention, which microtiter plate comprises a plurality of containers, wherein the bottom of each container comprises a (semi-)permeable membrane capable of directly or indirectly binding an analyte, and wherein each container is separated from... Agent: Ladas & Parry

20070065815 - Methods for genotyping hepatitis c virus: The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those... Agent: Medlen & Carroll, LLP

20070065812 - Multiplexed rt-pcr assay for detection and separation of barley and cereal yellow dwarf viruses: RT-PCR primer multiplexes and a method for detecting the presence of Subgroup I and II barley or cereal yellow dwarf viruses in a sample. A first multiplex includes a first primer pair that selectively amplifies Subgroup I viruses, and a second primer pair that selectively amplifies Subgroup II viruses. A... Agent: Price Heneveld Cooper Dewitt & Litton, LLP

20070065848 - 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206, and 8843 molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305,... Agent: Millennium Pharmaceuticals, Inc.

20070065860 - Accelerated class i and class ii hla dna sequence-based typing: There is provided a method for directly typing or sequencing HLA class I or class II alleles from a tissue sample wherein at least one exon of the HLA class I or class II alleles from the sample is amplified in a locus specific manner utilizing two primers, wherein at... Agent: Dunlap, Codding & Rogers P.C.

20070065872 - Apparatus and methods for detecting dna in biological samples: Apparatus and methods are described for detecting target DNA in a biological sample using capture probes and electrically-assisted hybridization. The reaction cell is formed with an attachment surface of aluminum oxide for better thermal and physical properties, and the aluminum oxide surface is coated with anti-DIG antibody to provide a... Agent: Buchanan, Ingersoll & Rooney PC

20070065855 - Biochip and analytical instrument for analyzing same: There is provided a biochip capable of quantitatively grasping hybridization efficiency. In the biochip comprising a plurality of probe sites with target molecules bonded thereto, respectively, the probe sites disposed thereon, the marker sites with a known number of fluorescent molecules bonded thereto, respectively, are disposed. With the biochip, the... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20070065858 - Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors: The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell has undergone an... Agent: Osi Pharmaceuticals, Inc.

20070065826 - Cationic dye compound for detecting nucleic acid double strand, and detection method and apparatus using same: A cationic dye compound having novel uses, the cationic dye compound being capable of conveniently and rapidly detecting a nucleic acid double strand, and a detection method using the cationic dye compound are provided. This invention relates to a cationic dye compound for detecting a nucleic acid double strand, comprising:... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070065836 - Chromosome 1p36 polymorphisms and low bone mineral density: The invention provides methods and compositions for diagnosing risk of low BMD and risk of osteoporosis based on the detection of SNP identity for human chromosome 1p36 polymorphisms designated in the NCBI SNP database (dbSNP) as rs2794328, rs446529, rs397559 and rs1802353.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070065830 - Cloning multiple control sequences into chromosomes or into artificial centromeres: Artificially synthesizing 29 homozygous cystic fibrosis core panel controls demonstrates placing multiple homozygous mutant sequences on the same single control DNA sequence to streamline quality control by minimizing extra control assays, time, and costly formatted test materials and testing all controls during every test. Any rare or unavailable reported DNA... Agent: Brouse Mcdowell Lpa

20070065874 - Compositions and methods comprising control nucleic acid: The present invention relates, in part, to control nucleic acid molecules having no significant sequence homology to any known nucleic acid, and predefined G/C-content. The present invention further relates to method of using control nucleic acid molecules to validate microarray analyses, compositions comprising control nucleic acid molecules, and kits comprising... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070065866 - Compositions and methods for suppressing fibrocytes: The present invention relates to the ability of anti-FcγR antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions resulting from fibrosis in the liver, kidney, lung, heart and pericardium, eye, skin, mouth,... Agent: Michelle Lecointe Baker Botts L.L.P.

20070065832 - Computer-implemented biological sequence identifier system and method: A computer-implemented biological sequence identifier (CIBSI) system and method for selecting a subsequence from biological sequence data according to at least one selection parameter. The at least one selection parameter corresponds to a likelihood of returning a meaningful result from a similarity search.... Agent: Naval Research Laboratory Associate Counsel (patents)

20070065847 - Degeneratively labeled probes: The invention is directed to methods for determining whether any of group of analytes of interest are present in a sample, and optionally, in at least one subsequent determination, which of the analytes are present. The invention is also directed towards methods for the rapid and efficient determination of the... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070065842 - Detection of survivin in the biological fluids of cancer patients: The present invention includes a method for diagnosing cancer comprising detecting the presence of survivin in the biological fluid of a patient. The present invention also provides kits comprising one or more agents that detect survivin polypeptide or survivin nucleic acid and a container for collecting biological fluid for testing.... Agent: Morgan Lewis & Bockius LLP

20070065825 - Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed: The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity.... Agent: Knobbe Martens Olson & Bear LLP

20070065835 - Dna fingerprinting using a branch migration assay: A method of determining the length of a polynucleotide target is provided. With this method, a target is first hybridized to an array of first probes having different, determined lengths, resulting in the formation of duplexes between the polynucleotide target and the first probes. These duplexes have a single stranded... Agent: Lumen Intellectual Property Services, Inc.

20070065831 - Function and regulation of adamts-1: The present invention relates to ADAMTS-1 and uses thereof. The present invention also relates to fragments of ADAMTS-1 and methods of inhibiting cell growth and metastasis. The present invention also provide methods of identifying inhibitors and activators relating to the function of ADAMTS-1.... Agent: Cozen O'connor, P.C.

20070065827 - Gene expression profiles and methods of use: The present invention relates to gene expression profiles, microarrays comprising nucleic acid sequences representing gene expression profiles, and methods of using expression profiles and microarrays. The invention also provides methods and compositions for diagnostic assays for detecting cancer and therapeutic methods and compositions for treating cancer. The invention also provides... Agent: Jeffrey M. Greenman

20070065845 - Gene expression profiling in biopsied tumor tissues: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon... Agent: Heller Ehrman LLP

20070065846 - Gene expression profiling in biopsied tumor tissues: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon... Agent: Heller Ehrman LLP

20070065852 - Hiv recombinant vaccine: Reagents and methods for making and using HIV recombinant vaccines are disclosed.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070065873 - Human t2r55 taste receptor and related assays for identifying human bitter taste modulators: The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R55 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor.... Agent: Hunton & Williams LLP Intellectual Property Department

20070065870 - Human t2r67 taste receptor and related assays for identifying human bitter taste modulators: The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R67 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor.... Agent: Hunton & Williams LLP Intellectual Property Department

20070065871 - Human t2r71 receptor and related assays for identifying human bitter taste modulators: The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R71 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor.... Agent: Hunton & Williams LLP Intellectual Property Department

20070065868 - Il-17 receptor like molecules and uses thereof: Novel IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17... Agent: Marshall, Gerstein & Borun LLP

20070065829 - In vitro differentiation of vascular smooth muscle cells, methods and reagents related thereto: This invention is directed to an in vitro system for rapidly and uniformly inducing immortalized neural crest cells to differentiate to vascular smooth muscle cells. As excessive proliferation of vascular smooth muscle cells is a phenotypic response to the development of occlusive arteriosclerotic disease, the in vitro system of this... Agent: Foley Hoag, LLP Patent Group (w/huv Hmv)

20070065820 - Lipid-associated molecules: Various embodiments of the invention provide human lipid-associated molecules (LIPAM) and polynucleotides which identify and encode LIPAM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LIPAM.... Agent: Foley And Lardner LLP Suite 500

20070065876 - Marking: The invention provides a marking system, markers and methods of use of such marking systems and markers which enable unique marking of articles and subsequent detection of that marking. In particular the invention provides a marking system, the marking system comprising a plurality of different DNA fragment types, each of... Agent: Merchant & Gould PC

20070065864 - Message abundance and allele copy number determination using ivt with single-stranded primer-promoter-selector constructs: Disclosed is a single stranded primer-promoter-selector construct comprising (in 3′ to 5′ orientation) a primer subsequence annealing to the target, a T7 or other promoter subsequence (the template strand), and a selector subsequence. The primer can be extended by template mediated elongation, including reverse transcription, or ligation to another oligonucleotide.... Agent: Eric P. Mirabez

20070065823 - Method and compositions for detection and enumeration of genetic variations: Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single particle to... Agent: Banner & Witcoff

20070065834 - Method and sequences for determinate nucleic acid hybridization: Provided are methods for using nucleic acid sequences having two or more degenerately pairing nucleotides, each degenerate nucleotide having a partially overlapping set of complementarity, to reduce the number of hybridizing nucleotide sequences or probes used in biochemical and molecular biological operations having sequence specific hybridization. The method may be... Agent: Searete LLC Clarence T. Tegreene

20070065851 - Method for detecting a microorganism in a fecal specimen: The invention relates to detecting microorganisms in specimens for the purposes of inter alia diagnoses, screenings, quarantine inspections, and clinical tests. Specifically, it relates to detecting and quantifying enteropathogenic bacteria in a fecal specimen, including Shigella species, Salmonella species, Campylobacter species, enterohemorrhagic E. coli or Verocytotoxin-producing E. coli, Vibrio cholerae,... Agent: Trask Britt

20070065863 - Method for detecting a risk of cardiovascular disease: Single nucleotide polymorphisms associated with serum C-reactive protein levels are disclosed. Also disclosed are methods of using these markers to predict the propensity for cardiovascular diseases and the time to first myocardial infarction.... Agent: Quarles & Brady LLP

20070065850 - Method for diagnosis of heart failure: A method for diagnosis of heart failure in a human subject, which comprises the step of: measuring an endoplasmic reticulum (ER)-initiated apoptotic signal such as CHOP in a biological sample originated from the subject is disclosed. According to the invention, by employing the new marker in stead of or in... Agent: Sughrue Mion, PLLC

20070065824 - Method for the detection of cytosine methylations in dna by means of cytidine deaminases: The present invention concerns a method for investigating cytosine methylations in DNA sequences. By this means, the DNA to be investigated is reacted with a cytidine deaminase which deaminates cytidine more rapidly than 5-methylcytidine. Cytosine is converted to uracil by the conversion, whereas 5-methylcytosine remains essentially unchanged. The enzymatically pretreated... Agent: Kriegsman & Kriegsman

20070065833 - Method of detecting thyroid cancer: A method of detecting thyroid cancer in a subject includes obtaining a nucleic acid sample from a bodily sample of the subject and determining whether the nucleic acid sample contains at least one of thyroid stimulating hormone receptor (TSHR) mRNA or thyroglobulin (Tg) mRNA.... Agent: Tarolli, Sundheim, Covell & Tummino L.L.P.

20070065839 - Method of identifying agents to prevent or treat diabetes: The invention provides an assay for identifying agents that can prevent and treat diabetes. Specifically, the assay is a novel tool for identifying agents that can up regulate cholecystokinin (CCK) expression in pancreatic islets of mammals. The increased expression of CCK triggers an increase in pancreatic β-cell mass and plasma... Agent: Quarles & Brady LLP

20070065837 - Methods and compositions for the detection of chlamydia trachomatis: The present invention provides novel methods for determining the presence or absence of Chlamydia in a patient, as well as diagnostic kits useful in practicing the methods of the invention. The methods of the invention are based on nucleic acid amplification reactions to detect both Chlamydia genomic and cryptic plasmid... Agent: Seed Intellectual Property Law Group PLLC

20070065841 - Methods and compositions for the removal of nucleic acid amplification inhibitors: An improved method for preparing nucleic acid extracts from environmental samples contaminated by polymerase inhibitors such as humic and fulvic acids is provided. The methods of the invention utilize chemical compositions capable of precipitating humic and/or fulvic acids from organic samples. The methods may be used in connection with the... Agent: Los Alamos National Security, LLC

20070065859 - Methods and materials for identifying the origin of a carcinoma of unknown primary origin: The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into an algorithm where the algorithm normalizes the Biomarkers against a reference; and... Agent: Philip S. Johnson Johnson & Johnson

20070065862 - Methods for analysis of genetic interactions: The present invention provides an isolated interaction polynucleotide that contains a tag sequence and two or more genetic elements. The present invention also provides a method for identifying an interaction between two or more genetic elements. One embodiment of the present invention provides a method for analyzing and identifying the... Agent: Angela Foster, Ph.d., Esq.

20070065861 - Methods for genetic analysis of alternative splicing: The present invention provides methods for large-scale functional analysis of splicing variants. Specifically, the present methods provide polynucleotide probes that incorporate exon junction sequences arising from alternative splicing events. In one embodiment of this invention, the function of a splice variant is determined by identifying a polynucleotide comprising an exon... Agent: Angela Foster, Ph.d., Esq.

20070065816 - Methods for genotyping: Novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample are provided. A reduced complexity sample is generated and then analyzed. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070065869 - Methods for producing ligand arrays: Methods for producing ligand arrays, e.g., peptide and nucleic acid arrays, as well as the arrays produced thereby, methods for use of the arrays and kits that include the same are provided. In one embodiment of the subject methods, a substrate having a surface displaying acetate functional groups that produce... Agent: Agilent Technologies Inc.

20070065821 - Methods for the prediction of suicidality during treatment: This invention provides methods to predict the likelihood of suicidal or self-destructive behavior in a patient during treatment. The method employs the detection of a polymorphism in the SLC6A3 gene at Exon 9 A59G or a surrogate marker, by various methods. Also provided are methods of treatment based on the... Agent: Novartis Corporate Intellectual Property

20070065856 - Molecular method for diagnosis of prostate cancer: Methods for diagnosing or detecting cancerous prostate tissue. A panel of 8 specific marker genes are provided. The overexpression of some of these marker genes compared to their expression in normal prostate tissue and the underexpression of the rest of these marker genes are indicative of cancerous prostate tissue. By... Agent: Cassan Maclean

20070065819 - Novel fprl1 ligands and use thereof: By using FPRL1 ligand, which comprises the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 17 or SEQ ID NO: 21, and FPRL1, an efficient screening for FPRL1 agonist or FPRL1 antagonist can be performed.... Agent: Takeda Pharmaceuticals North America, Inc Intellectual Property Department

20070065840 - Novel oligonucleotide compositions and probe sequences useful for detection and analysis of micrornas and their target mrnas: The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNAs and their target mRNAs, as well as small interfering RNAs (siRNAs). The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single... Agent: Clark & Elbing LLP

20070065875 - Ntb-a, a surface molecule involved in natural killer cells activity: The present invention relates to a novel protein, termed NTB-A, nucleic acid molecules encoding the same and uses thereof. The invention also relates to methods of regulating Natural Killer cells activity by regulating the activity of NTB-A in vitro, ex vivo or in vivo. The invention also comprises methods of... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070065849 - Nucleic acid encoding eosinophil eotaxin receptor: The eosinophil eotaxin receptor has been isolated, cloned and sequenced. This receptor is a human β-chemokine receptor and has been designated “CC CKR3”. The eosinophil eotaxin receptor may be used to screen and identify compounds that bind to the eosinophil eotaxin receptor. Such compounds would be useful in the treatment... Agent: Merck And Co., Inc

20070065853 - Nucleic acid preparation from whole blood for use in diagnosis of transmissible spongiform encephalopathy: The present invention deals with a method of preparing nucleic acids, particularly RNA, from a whole blood sample. The nucleic acids purified by the method of the invention are particularly suited for detection of nucleic acid marker molecules. Preferred are markers for the diagnosis of transmissible spongiform encephalopathy (TSE). Such... Agent: Roche Diagnostics Operations Inc.

20070065817 - Nucleic acid probes for detection of non-viral organisms: The present invention relates to nucleic acid probes which are derived from rRNA genes of non-virus organisms and are useful for the detection of said non-virus infectious organisms in a biological sample. In addition, the present invention relates to compositions and chips useful for the diagnosis of one or more... Agent: Joseph Hyosuk Kim Jhk Law

20070065828 - Oligonucleotide for genotyping of mycoplasma, microarray comprising the oligonucleotide, and method for detection of species using the microarray: As described above, the present invention provides a rapid and accurate assay method capable of simultaneously detecting many Mycoplasma and its related strains from a single sample using a microarray comprising novel oligonucleotides for detecting Mycoplasma and its related strains which are known as a source of contamination of cell... Agent: The Rafferty Patent Law Firm

20070065838 - Oligonucleotide mediated nucleic acid recombination: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.... Agent: Maxygen, Inc. Intellectual Property Department

20070065857 - Optical system for plant characterization: A system is provided to monitor targeted pest populations, disease, presence of transgenic and non-transgenic plants, or targeted pest population in a transgenic crop using remote imagery to discern differences in crops along with pest infestation in all crop varieties. The system relies on the fact that plant leaves are... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070065818 - Photoprotein with improved bioluminescence: Disclosed is a photoprotein with improved luminescent activity, the use thereof as calcium indicator and in cell-based assays for the detection and measurement of intracellular calcium.... Agent: Arent Fox PLLC

20070065865 - Polymorphisms associated with coronary artery disease: The invention provides human polymorphisms that are associated with coronary artery disease (CAD). Polymorphisms in genes were identified that confer an increased susceptibility to CAD or a decreased susceptibility. Particular alleles of the polymorphisms were identified as being associated with differential risk. In particular an allele of CDC42 in combination... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070065843 - Polymorphisms in mitochondrial transcription factor a (\"tfam\") gene and their associations with measures of marbling and subcutaneous fat depth in beef cattle: The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention relates to the identification of single nucleotide polymorphisms (SNPs) within the bovine... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070065867 - Promoter and plasmid system for genetic engineering: This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a terminator sequence, the plasmids containing variants of glucose isomerase promoters for varying levels of protein expression. The materials and methods are useful... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070065854 - Serum-free medium for producing retroviruses: A method for obtaining a virus vector free of a serum, and a serum-free medium for cultivation of a virus producer cell which can be used for the method are provided. By cultivating a virus producer cell using a serum-free medium containing serum albumin, it is possible to cultivate the... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070065844 - Solution-based methods for rna expression profiling: The present invention is directed to novel high-throughput, low-cost, and flexible solution-based methods for RNA expression profiling, including expression of microRNAs and mRNAs.... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20070065822 - Substrates for spatially selective micron and nanometer scale deposition and combinatorial modification and fabrication: A substrate (1) for spatially selective micron and nanometer scale deposition and/or reaction, which has a support (3), a conductive layer (5) on the support, a dielectric layer (7) to hold an electrostatic charge pattern such as a photoconductive layer of a material which dissipates an electric charge upon receiving... Agent: Brinks Hofer Gilson & Lione

20070065878 - Cellular libraries of peptide sequences (clips) and methods of using the same: The present invention provides compositions including peptide display scaffolds that present at least one candidate peptide and at least one detectable moiety in at least one of the N-terminal and C-terminal candidate peptide presenting domains that when expressed in a cell are accessible at a surface of the cell outermembrane.... Agent: Bozicevic, Field & Francis LLP

20070065880 - Compositions and methods relating to elutable carbohydrate-binding proteins: Compositions and methods are provided for creating and identifying mutant carbohydrate-binding proteins that reversibly bind to carbohydrate substrates under conditions where the native protein remains bound. Examples of modified chitin-binding domains are provided which can be eluted from chitin in the presence of a reducing agent or at a pH... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20070065879 - Marker for inflammatory conditions: Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.... Agent: Fish & Richardson P.C.

20070065877 - Microarray having a base cleavable succinate linker: There is disclosed a microarray having base cleavable succinate linkers. The microarray has a solid surface with known locations, each having reactive hydroxyl groups. The density of the known locations is greater than approximately 100 locations per square centimeter. Amino moieties are attached to the reactive hydroxyl groups. Preferably the... Agent: Combimatrix Corporation

20070065882 - Acetylcholinesterase-derived peptides and uses thereof: The invention relates to a cell growth and/or differentiation regulatory peptide comprising a sequence of about 9 to about 150 amino acids derived from acetylcholinesterase amino acid sequence, preferably from the C-terminal region of acetylcholinesterase. The invention also relates to pharmaceutical compositions comprising the peptides, particularly for use in promoting... Agent: Cooper & Dunham, LLP

20070065881 - Isolated cytotoxic factor associated with multiple sclerosis and method of detecting said cytotoxic factor: The invention relates to an isolated cytotoxic factor which is associated with multiple sclerosis and which is selected from the heterocomplex GM2AP/GM2/MRP14 and mutated GM2AP/GM2/MRP14, and to the method of detecting said factor in a biological sample to be tested. The inventive method comprises the following steps consisting in: (i)... Agent: Oliff & Berridge, PLC

20070065884 - Mammalian sour/acid taste and csf receptor genes, polypeptides and assays: Acid/sour taste receptors are provided. CSF pH sensing receptors are provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals, antibodies to the receptors, methods of detecting polymorphisms, and methods of correcting taste defects are also provided.... Agent: Quine Intellectual Property Law Group, P.C.

20070065885 - Methods for shp1 mediated neuroprotection: The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level... Agent: Philip S. Johnson Johnson & Johnson

20070065883 - Molecules that modulate galphaq activity and methods of treating urinary incontinence: The present invention provides methods that are useful for the treatment or prevention of smooth muscle disorders such as urinary incontinence and compounds that are useful in such methods.... Agent: Jones Day

20070065889 - Compositions and methods to diagnose and treat lung cancer: The present invention provides methods for aiding in the diagnoses of the condition of a lung cell, and methods of screening for a potential therapeutic agents for cytolysis or apoptosis of lung cancer cells.... Agent: Genzyme Corporation Legal Department

20070065887 - Diagnosis of pre-cancerous conditions using pcdgf agents: The present invention relates to methods and compositions designed for the treatment or management of pre-cancerous conditions, especially in order to prevent, delay, or decrease the likelihood that the pre-cancerous condition will progress to malignant cancer. The methods of the invention comprise the administration of an effective amount of one... Agent: Jones Day

20070065890 - Method for promoting formation of facultative heterochromatin: The present invention is a method for promoting facultative heterochromatin formation using SirT1. Using novel anti-SirT1 and anti-acetylated histone H1 antibodies, human SirT1 protein was shown to interact with and deacetylate histone H1 at lysine 26. Moreover, SirT1 was shown to mediate deactylation of histones H3 and H4 and spreading... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20070065888 - Reagents and methods for use in cancer diagnosis, classification and therapy: Methods and reagents for classifying tumors and for identifying new tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents... Agent: Choate, Hall & Stewart LLP

20070065891 - Method of pretreating sample and immunological assay method using the same: The invention provides a method of pretreating a sample for conveniently, quickly and accurately measuring the total amount of adiponectin present in a biological sample contaminated with various adiponectin multimers. The method of measuring an sample for immunologically assaying the total amount of adiponectin present in the sample comprises reacting,... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070065886 - Antibodies and methods for predicting dental caries: The present invention relates to antibodies, binding portions thereof, or probes that bind specifically to glucosyltransferase enzymes, and uses of these agents for detecting glucosyltransferase enzyme(s) in a sample and for diagnosing predisposition of a human child to early childhood caries. The present invention also relates to a kit for... Agent: Nixon Peabody LLP - Patent Group

20070065892 - High throughput assay of lp-pla2 activity: This invention relates to a method for determining the activity of Lp-PLA2 in a plurality of samples from animals. The invention also relates to a kit for determining Lp-PLA2 activity in a plurality of samples.... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20070065893 - Liquid-phase galactose oxidase-schiff's assay: The invention provides an improved method for detecting cancer or a precancerous condition in a sample using an oxidation agent, such as galactose oxidase, and an aldehyde detection agent, such as Schiff's reagent that does not require the sample to be immobilized onto a solid support. The invention also provides... Agent: Bereskin And Parr

20070065894 - Method for quantification of biological material in a sample: Methods for the detection and/or quantification of a biological material in a sample. The method includes the steps of liquefying the sample (if necessary) and pouring the liquefied sample into the incubation vessel. The incubation vessel has a generally flat horizontal surface and the surface is divided into at least... Agent: Seed Intellectual Property Law Group PLLC

20070065898 - Fluorescence polarization assays for binding of caspase inhibitors and probes therefor: t

20070065897 - Human prss11-like s2 serine protease and uses thereof: A novel human cDNA, termed PRSS11-L, was isolated which encodes a polypeptide that belongs to the S2/HtrA serine protease family. The PRSS11-L mRNA is widely expressed in several tissues throughout the body by multi-tissue Northern blotting. The full-length PRSS11-L cDNA, was cloned, expressed and purified. Proteolytic activity was demonstrated using... Agent: Philip S. Johnson Johnson & Johnson

20070065896 - Methods and kits for quantifying metabolites or analytes: Methods and kits for quantifying the amount of a metabolite, such as homocysteine, methionine or cysteine, in a sample are disclosed. This involves contacting the sample with a first enzyme capable of degrading a metabolite into a plurality of reaction products and regenerating the metabolite using a second enzyme which... Agent: Dann, Dorfman, Herrell & Skillman

20070065895 - Substrates specific to von willebrand factor cleaving protease and method of assaying the activity: The present invention relates to specific substrates for a von Willebrand factor cleaving enzyme, ADAMTS-13, as well as to diagnosis of ADAMTS-13 deficient patients, diagnostic compositions, and kits employing the substrates. Particularly preferable substrate polypeptides for ADAMTS-13 are the polypeptide which begins at amino acid 1587 and ends at amino... Agent: Birch Stewart Kolasch & Birch

20070065899 - Strains for the production of organic acids: A method of producing an organic acid by staining a yeast population with a stain capable of internal pH (pHi)-dependent fluorescence, to yield a stained yeast population; determining a gate pH and a corresponding fluorescence parameter of the stained yeast population; and sorting the cells of the stained yeast population... Agent: Williams, Morgan & Amerson

20070065900 - Process for chromosomal expression of foreign genes in the cytochrome-c peroxidase (cytcp) region of a methylotrophic microbial host cell: Provided is a method for expressing an introduced gene or genes in a methylotrophic microorganism host wherein the gene(s) are integrated into the cytCP region of the chromosome. This method provides stable, high-level expression of the integrated genes in which growth rate of the host strain is not highly affected... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070065902 - Process for chromosomal expression of foreign genes in the flic region of a methylotrophic microbial host cell: Provided is a method for expressing an introduced gene or genes in a methylotrophic microorganism host wherein the gene(s) are integrated into the fliC region of the chromosome. This method provides stable, high-level expression of the integrated genes in which growth rate of the host strain is not adversely affected... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070065903 - Process for chromosomal expression of foreign genes in the hsdm region of a methylotrophic microbial host cell: Provided is a method for stably expressing an introduced gene or genes in a methylotrophic microorganism host wherein the gene(s) are integrated into the hsdM region of the chromosome. This method provides stable, high-level expression of the integrated genes in which growth rate of the host strain is not highly... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070065901 - Process for chromosomal expression of foreign genes in the paps reductase (cysh) region of a methylotrophic microbial host cell: Provided is a method for stably expressing an introduced gene or genes in a methylotrophic microorganism host wherein the gene(s) are integrated into the cysH region of the chromosome. This method provides stable, high-level expression of the integrated genes in which growth rate and/or viability of the host strain is... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070065914 - Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070065917 - Endogenous and non-endogenous, constitutively activated human g protein-coupled receptions: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown (“orphan GPCR receptors”), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.... Agent: Cozen O'connor, P.C.

20070065911 - Hepatitis c virus vaccine: The present invention relates to isolation of a novel Hepatitis C virus, more particularly, the present invention relates to a viral class Hepatitis C, polypeptides, polynucleotide, vaccine and antibodies derived there from.... Agent: Oliff & Berridge, PLC

20070065908 - Human cathelicidin antimicrobial peptides: Provided are peptide and peptide consensus sequences, which inhibit bacterial growth and/or viral growth and mimic the activity of LL-37, CRAMP, and/or FALL-39. The peptides are useful as antimicrobials, ant-inflammatories and antiviral agents.... Agent: Buchanan, Ingersoll & Rooney LLP

20070065913 - Isolation of binding proteins with high affinity to ligands: The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating binding proteins capable of binding small molecules and peptides via “display-less” library screening. In the technique, libraries of candidate binding proteins, such as antibody sequences, are expressed in soluble form in the periplasmic space... Agent: Fulbright & Jaworski L.L.P.

20070065912 - Multiple gene expression including sorf constructs and methods with polyproteins, pro-proteins, and proteolysis: Disclosed are useful constructs and methods for the expression of proteins using primary translation products that are processed within a recombinant host cell. Constructs comprising a single open reading frame (sORF) are described for protein expression including expression of multiple polypeptides. A primary translation product (a pro-protein or a polyprotein)... Agent: Greenlee Winner And Sullivan P C

20070065910 - Mutations for enhanced tyrosine production: The present invention provides cells genetically engineered to express mutated chorismate mutase/prephenate dehydrogenase (CM/PDH), the nucleic acid coding for each mutated CM/PDH and similar nucleic acids and methods for utilizing cells expressing mutated CM/PDH to produce tyrosine.... Agent: Pearl Cohen Zedek, LLP Pearl Cohen Zedek Latzer, LLP

20070065915 - Nucleic acid expressed in the hypothalamus or muscle tissue in obese animals: An isolated nucleic acid molecule comprising a sequence of nucleotides encoding or complementary to a sequence encoding a molecule or derivative or homologue thereof wherein said nucleic acid molecule is expressed in a larger amount in one or both hypothalamus tissue or muscle tissue of obese animals compared to lean... Agent: Seed Intellectual Property Law Group PLLC

20070065916 - Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from comamonas testosteroni 5-mgam-4d and recombinant organisms expressing those enzymes useful for the production of amides and acids: The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitrites to the corresponding amides, and the amidase is useful for hydrolysis of amides to... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070065905 - Process for expression and secretion of proteins by the non-conventional yeast zygosaccharomyces bailii: Herein is disclosed a method for the production of proteins. The protein is expressed by a yeast belonging to the species Zygosaccharomyces bailii. The yeast secretes the protein produced into the culture medium from where it is isolated, thereby simplifying the isolation process. Preferably the yeast is cultivated in chemically... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070065906 - Process for producing heterologous protein in e. coli: A heterologous protein free from an inducer and a method for producing said protein are provided. A method for producing a heterologous protein which comprises the step of optionally culturing at low temperature recombinant E. coli cells expressing a heterologous protein under control of a promoter capable of inducing expression... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070065907 - Process for the production of biological substances by perfusion culturing of suspended animal cells: The invention relates to a process for the production of a biological substance by perfusion culturing of suspended animal cells in a serum free cell culture medium, wherein the biological substance is separated from the cells by filtration, characterized in that at least 0.001 w/w % nonionic surfactant is present... Agent: Nixon & Vanderhye, PC

20070065909 - Prokaryotically produced antibodies and uses thereof: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.... Agent: Merchant & Gould PC

20070065904 - Recombinant expression vectors for functional nav1.9 sodium channels: The present invention is drawn to the stable cloning and expression of Nav1.9 sodium channel at the mRNA and protein levels, production of sodium channel currents characteristic of native currents in dorsal root ganglion neurons and to cell lines transiently or stably expressing recombinant Nav1.9 sodium channel.... Agent: Choate, Hall & Stewart LLP

20070065918 - Purified mammalian cytokines; related reagents and methods: CTLA-8 related antigens from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigens. Methods of using said reagents and diagnostic kits are also provided.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070065919 - Methods of producing stable b-lymphocytes: The invention provides a method of producing a stable lymphocyte culture and methods of producing monoclonal antibodies.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070065920 - Borrelidin-producing polyketide synthase and its use: The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials and methods including enzyme systems, nucleic acids, vectors and cells are provided for the preparation of... Agent: Dann, Dorfman, Herrell & Skillman

20070065921 - Methods and products related to producing low molecular weight heparin: The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.... Agent: Wolf Greenfield & Sacks, PC

20070065922 - Biocatalytic synthesis of aminodeoxy purine n9-beta-d-nucleosides containing 3-amino-3-deoxy-beta-d-ribofuranose, 3-amino-2,3-dideoxy-beta-d-ribofuranose, and 2-amino-2-deoxy-beta-d-ribofuranose as sugar moieties: Purine N9-β-D-nucleosides containing 3-amino-3-deoxy-β-D-ribofaranose, 3-amino-2,3-dideoxy-β-D-ribofuranose, and 2-amino-2-deoxy-β-D-ribofuranose as sugar moieties are synthesized by biocatalytic transglycosylation of purine bases and the respective 3′-amino-3′-deoxyuridine, 3′-amino-3′-deoxythymidine and 2′-amino-2′-deoxyuridine as donors of the carbohydrate moiety, and the cells of Escherichia coli as a biocatalyst or glutaraldehyde (GA) treated cells of Escherichia coli as a... Agent: Banner & Witcoff

20070065925 - Circovirus sequences associated with piglet weight loss disease (pwd): The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a... Agent: Bingham, Mccutchen LLP

20070065924 - Isolated polynucleotide sequence with ires activity: Provided herein is an isolated polynucleotide sequence with internal ribosome entry site (IRES) activity, which directs translation initiation in an insect expression system in a cap-independent manner. In particular, the invention relates to an isolated polynucleotide comprises the 5′ UTR of perina nuda Picorna-like virus (PnV) that possesses IRES activity.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070065923 - Peptides for discrimination of prions: The aim of the present invention is to provide a non-intrusive way to isolate, concentrate and monitor the TSE disease-related pathogenic prion protein. The invention described several peptides and their ability to capture PrPSc from brain homogenate of prion disease infected animal and human. These eight peptides do not capture... Agent: Philip S. Johnson Johnson & Johnson

20070065926 - Circular site-directed mutagenesis: The invention provides improved methods of introducing site-directed mutations into circular DNA molecules of interest by means of mutagenic primer pairs. The mutagenic primer pairs are also selected so as to be either completely complementary or partially complementary to each other, wherein the mutation site (or sites) is located within... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070065927 - Use of pure oxygen in viscous fermentation processes: A fermentation process uses substantially pure oxygen as the sole gas introduced into a fermentation vessel while fermentation reactions are active. The oxygen is introduced at multiple locations along the height of the vessel, and is preferably introduced in the vicinity of the blades of an impeller. The invention enhances... Agent: Air Liquide

20070065928 - Genes encoding carbon metabolism and energy-producing proteins: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.... Agent: Lahive & Cockfield, LLP

20070065929 - Bengamide derivatives, process for preparing them, and their use: The present invention relates to bengamide derivatives which are formed, during fermentation, by the microorganism Myxococcus virescens ST200611 (DSM 15898), to their use for treating cancer diseases, to pharmaceuticals which comprise bengamide derivatives, to a process for preparing bengamides of the formula (V) and to the microorganism Myxococcus virescens ST200611... Agent: Ross J. Oehler Sanofi-aventis U.s. LLC

20070065930 - Biocatalyst for production of d-lactic acid (as amended): A method for producing D-lactic acid in high yield, and to provide a method for producing D-lactic acid with high selectivity, in which optical purity is high and a by-product organic acid is small. In one aspect, a microorganism, wherein activity of pyruvate formate-lyase (pfl) is inactivated or decreased, and... Agent: Buchanan, Ingersoll & Rooney PC

20070065931 - Zinc finger proteins for dna binding and gene regulation in plants: Disclosed herein are modified plant zinc finger proteins; compositions comprising modified plant zinc finger proteins and methods of making and using modified plant zinc finger proteins. The modified plant zinc finger proteins, in contrast to naturally-occurring plant zinc finger proteins, have a binding specificity that is determined by tandem arrays... Agent: Robins & Pasternak

20070065932 - Bengamide derivatives, process for preparing them, and their use: The present invention relates to bengamide derivatives which are formed, during fermentation, by the microorganism Myxococcus virescens ST200611 (DSM 15898), to their use for treating cancer diseases, to pharmaceuticals which comprise bengamide derivatives, to a process for preparing bengamides of the formula (V) and to the microorganism Myxococcus virescens ST200611... Agent: Ross J. Oehler Sanofi-aventis U.s. LLC

20070065933 - Tray stack adapted for active gassing: A stack of communicating trays for cultivation of cells, whereby the tray stack is equipped with a gas exchanger having at least one processed aperture for fast and substantially uniform distribution of gas to the trays.... Agent: Volentine Francos, & Whitt PLLC

20070065934 - Amplification of enzymatic reactions for use with an enthalpy array: Provided is a method of detecting characteristics of a reaction of interest, including instituting the reaction of interest, obtaining an amplified heat related to the reaction of interest, measuring the amplified heat, and determining the characteristics of the reaction of interest, using the signal obtained in the step of measuring.... Agent: Fay Sharpe / Xerox - Parc

20070065935 - Polymeric microarray support, method of forming microfeatures on an optical assay arrangement: The invention comprises a polymeric microarray support (1) for an optical assay arrangement (2) comprising optical means (3, 4, 6) for detection of light emitted from the support. The microarray support is provided with microfeatures comprising a surface enlarging pattern (5), i.e. grooves having a selected depth (8). The depth... Agent: Morrison & Foerster LLP

20070065936 - Tissue culture microscope apparatus: A tissue culture microscope apparatus includes a culture unit that includes a chamber in which a specimen is put, and maintains the chamber at a predetermined temperature to culture the specimen; an observation unit that forms an observation image of the specimen put in the chamber; and a liquid supply... Agent: Frishauf, Holtz, Goodman & Chick, PC

20070065937 - System and method for composting: A system and method for composting involving air directed from the interior of a livestock housing to an area which surrounds material to be composted in a composting container located in close proximity to the livestock housing. Air is preferably directed from the livestock housing to the area surrounding the... Agent: Ade & Company

20070065940 - Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same: The object of the present invention is to provide the following: a method for preparing a basement membrane which is extracellular matrices having a function to control morphology, differentiation, proliferation, motility, function expression and the like of cells; a method for constructing a specimen of a basement membrane; a process... Agent: Frommer Lawrence & Haug

20070065938 - Perivascular mesenchymal precursor cells: Mesenchymal precursors cells have been isolated from perivascular niches from a range of tissues utilizing a perivascular marker. A new mesenchymal precursor cell phenotype is described characterized by the presence of the perivascular marker 3G5, and preferably also alpha smooth muscle actin together with early developmental markers such as MUC... Agent: Cooper & Dunham, LLP

20070065939 - Systems for detection and production of respiratory, herpes and enteric viruses: The present invention generally relates to the field of diagnostic microbiology, and, more particularly to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial... Agent: Medlen & Carroll, LLP

20070065941 - Neuronal cells obtained by electric pulse treatment of es cells: It is an object of the present invention to apply a novel method of preparing neural cells from ES cells. The method of the present invention is characterized by the electric pulse treatment of differentiating ES cells. Nerve cells obtained by the method of the present invention have the flexibility... Agent: Birch Stewart Kolasch & Birch

20070065942 - Human renal stem cells: The present disclosure provides human renal stem cells. Also described are human renal stem cells isolated from the papillary region of the human kidney and methods of isolating the same. Also described are methods for culturing, characterizing, and differentiating the same, including methods for identifying human renal stem cells that... Agent: Gonzales Patent Services

20070065943 - Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof: A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having... Agent: Peters Verny Jones & Schmitt, L.L.P.

20070059678 - Breast milk contaminant detection device: A breast milk detection device includes a plurality of test strips slidably and removably coupled to a test housing. Each test strip is connected to an absorbent section so that a breast milk sample deposited thereon is communicated to the test strips. Each test strip includes an analyte-specific moiety for... Agent: Harshaw Research Incorporated

20070059679 - Method for demonstrating efficacy of a topically applied active ingredient: A method is disclosed for demonstrating the efficacy of a topically applied active ingredient, which method includes topically applying a composition containing an active ingredient to an area of skin, applying an absorbent material to the area of skin to extract at least a portion of the active ingredient from... Agent: Philip S. Johnson Johnson & Johnson

20070059680 - System for cell enrichment: The present invention provides systems useful for the enrichment of analytes, for example, cells of selected types, including but not limited to blood cells, stem cells, and pathogens, in samples. The invention also provides methods for analyzing the condition of a patient based on characteristics identified through analysis of the... Agent: Wilson Sonsini Goodrich & Rosati

20070059686 - Materials and methods for the detection of severe acute respiratory syndrome virus (sars): Disclosed are methods and kits for identifying a virus in a sample, which may include a coronavirus capable of causing Severe Acute Respiratory Syndrome (“SARS”) or SARS-like symptoms. The virus may be a SARS-Associated Coronavirus (“SARS-CoV”). Typically, the methods may include reacting a mixture that includes, in addition to nucleic... Agent: Eragen Biosciences, Inc. C/o Foley & Lardner LLP

20070059685 - Method for producing improved results for applications which directly or indirectly utilize gene expression assay results: A method for producing improved results for applications of any kind which directly or indirectly utilizes gene expression assay results.... Agent: Wesley B. Ames

20070059681 - Method for production of bioresorable microparticles, microparticles thus obtained and use thereof: The present invention relates to a method for preparing nonlamellar bioresorbable microparticles to which protein substances are bonded, characterized in that it comprises the steps of: (i) preparing said microparticles from at least one bioresorbable polymer without stabilizer and without surfactant, and (ii) bonding said protein substances to the microparticles... Agent: Oliff & Berridge, PLC

20070059684 - Method of identifying an antiviral agent: A method of identifying an antiviral agent effective against viruses, which utilize −1 programmed ribosomal frameshifting is provided. The method includes providing cells harboring a −1 frame plasmid including a translation start site followed by a −1 ribosomal frameshifting signal followed by a reporter gene which is in a −1... Agent: Hoffmann & Baron, LLP

20070059682 - Method to increase specificity and/or accuracy of lateral flow immunoassays: The present invention relates to a method for detecting an analyte in a sample, wherein the sample to be analyzed is applied to a chromatographic carrier. After separating from an interfering substance which may be present in the sample, the analyte of interest is detected on the carrier by means... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070059683 - Veterinary diagnostic system: The invention relates to a method for diagnosing an animal for a condition by obtaining a fluid sample from the animal, enriching a first analyte having a concentration of less than 1×10−3 analytes/μL from said sample by a factor of at least 10,000 fold; and analyzing one or more enriched... Agent: Wilson Sonsini Goodrich & Rosati

20070059690 - \"met/fret based method of target nucleic acid detection whereby the donor/acceptor moieties are on complementary strands\": Disclosure of a method for the detection and quantitation of polynucleotide sequences in a sample of biological or non-biological material through target poly nucleotide sequence amplification by polymerase chain reaction using chemically labeled oligonucleotide amplification primers and formation of an entity between the amplified polynucleotide sequence and chemically labeled polynucleotide... Agent: Stephan A. Pendorf, P.A.

20070059725 - Apparatus and method for detecting microscopic organisms using bacteriophage: Methods and apparatus are provided for detection of microorganisms in a sample. Methods and apparatus of the invention are based on the specificity that phage, for example bacteriophage, have for target microorganisms, for example bacterium. Typically, phage adsorption to target microorganisms act as signal, or a signal target, for the... Agent: Dorsey & Whitney, LLP Intellectual Property Department

20070059692 - Array oligomer synthesis and use: The present disclosure provides efficient and reproducible methods for individually synthesizing oligomers in a parallel manner (e.g., oligonucleotides) on a solid support to produce pools of oligomers. Pools of oligonucleotides can be used for a variety of genomic and proteomic applications, including synthesis of genes or long DNA of any... Agent: Vinson & Elkins, L.L.P.

20070059696 - Assessment method: The present invention relates generally to a method of diagnosing, predicting and/or monitoring the development or progress of an inflammatory response in a mammal. More particularly, the present invention relates to a method of diagnosing, predicting and/or monitoring the development or progress of an inflammatory response by analysing one or... Agent: Scully Scott Murphy & Presser, PC

20070059736 - Bio-analysis chip, bio-analysis system and bio-analysis method: A bio-analysis chip which is convenient in use and can promptly detect microbes with high accuracy. The bio-analysis chip comprises a collection member for collecting microbes in the atmosphere with the microbes adhering to the collection member, and a substrate in the form of a thin plate on which the... Agent: Mattingly, Stanger, Malur & Brundidge, P.C.

20070059745 - Blood assessment of injury: Methods of injury assessment in an individual include the steps of determining a pattern of expression exhibited by blood cells obtained from an individual and comparing the pattern of expression exhibited by the obtained blood cells to an injury database to assess the injury.... Agent: Dinsmore & Shohl, LLP

20070059719 - Business methods for prenatal diagnosis: The present invention relates to business methods in which screening services and diagnostics for the condition of a fetus are provided. Fetal abnormalities, include chromosomal and other genetic ies, are detected through the analysis of fetal cells obtained from maternal blood samples.... Agent: Wilson Sonsini Goodrich & Rosati

20070059735 - Compositions, methods and kits for determining the presence of chlamydophila pneumoniae in a test sample: The present invention relates to oligonucleotides useful for determining the presence of Chlamydophila pneumoniae in a test sample. The oligonucleotides of the present invention may be incorporated into detection probes, capture probes and amplification oligonucleotides, and used in various combinations thereof.... Agent: Gen Probe Incorporated

20070059728 - Computer-implemented biological sequence identifier system and method: A method of: submitting reference sequences to a taxonomic database to produce taxonomic results; and reporting a taxonomic identification based on the taxonomic results. The reference sequences are the output of genetic database queries that return a score for each reference sequence. A method for processing a biological sequence obtained... Agent: Naval Research Laboratory Associate Counsel (patents)

20070059744 - Corynebacterium glutamicum genes encoding novel proteins: Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070059741 - Deoxyribonucleic acid measuring apparatus and method of measuring deoxyribonucleic acid: With an insulated gate field effect transistor in which deoxyribonucleic acid (DNA) probes are immobilized on a gold electrode, extension reaction on the gold electrode is performed with DNA polymerase to directly measure an increased amount of a phosphate group caused by the extension reaction, that is, negative charge, by... Agent: Stanley P. Fisher Reed Smith LLP

20070059753 - Detecting gene methylation: Methods, kits, and compositions for detecting the methylation status of various genes are useful in various diagnostic applications involving suspected proliferative disorders such as prostate cancer.... Agent: Philip S. Johnson Johnson & Johnson

20070059714 - Detection of presence and antibiotic susceptibility of enterococci: The present invention relates in general to the detection of antibiotic resistance genes in Enterococci. The present invention discloses a micro-array for the detection of the presence of bacteria of the genus Enterococcus and antibiotic resistance genes in said organism, a method for the detection of said genes and a... Agent: Knobbe Martens Olson & Bear LLP

20070059732 - Detection of target analytes using particles and electrodes: The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte... Agent: Robin M. Silva Dorsey & Whitney LLP

20070059704 - Detection system: The invention provides a methods and materials for detecting an activity of a glycopeptide antibiotic (such as a vancomycin-type antibiotic), in a sample, the method comprising the steps of: (a) providing a microorganism in which a first endogenous gene encoding peptidyltransferase activity is inactivated, which activity is necessary for growth... Agent: Michael Best & Friedrich, LLP

20070059697 - Determining cancer-linked genes and therapeutic targets using molecular cytogenetic methods: Methods for identifying potential therapeutic agents, such as anti-tumor agents, based on their modulation of the expression of specified genes, especially genes mapping to specific chromosomal regions, are disclosed. Also described are methods for diagnosing cancerous, or potentially cancerous, conditions as a result of the expression, or patterns of expression,... Agent: Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein

20070059738 - Diagnosis and treatment of hepatic disorders: The present invention encompasses methods and compositions useful in diagnosing and treating hepatic disorders, especially those characterized by inflammation. The method comprises administration of an agent which prevents the interaction of MAdCAM with a MAdCAM binding partner or ligand. These compositions are useful in treating diseases or disorders involving α4β7/MAdCAM... Agent: Merchant & Gould PC

20070059694 - Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep1 (prostaglandin e2 ep1): The invention provides a human prostaglandin E2 EP1 which is associated with the cardiovascular diseases, respiratory diseases, hematological diseases, urological diseases, gastrointestinal diseases, endocrinological diseases and metabolic diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, respiratory diseases, hematological... Agent: Jeffrey M. Greenman

20070059726 - Differential transcript expression: Multiple transcripts from the same gene maybe differentially regulated. Finding such differential regulation under distinct physiological conditions implicates the gene in the generation or response to the physiological condition. Transcripts have been identified from five genes which appear to be differentially regulated in lung cancer and normal cells. We have... Agent: Genzyme Corporation Legal Department

20070059727 - Directional self-assembly of biological electrical interconnects: Microtubules are excellent candidates for the fabrication of nanostructures, including nanowires. A method for controlled nucleation and growth of microtubules on substrates (e.g., gold on a silicon wafer) is provided. The substrate is functionalized with a nucleating agent for microtubule growth. The method can be employed to generate nanoscale structures... Agent: Greenlee Winner And Sullivan P C

20070059702 - Disease related protein network: The present invention relates to a method for generating a network of direct and indirect interaction partners of a disease-related (poly)peptide comprising the steps of (a) contacting a selection of (poly)peptides suspected to contain one or several of said direct or indirect interaction partners with said disease-related (poly)peptides and optionally... Agent: Louis M Heidelberger Reed Smith

20070059701 - Fluorescence assays for nucleic acid polymerase activity: The present invention provides methods of detecting nucleic acid polymerase activity and methods of detecting compounds that modulate nucleic acid polymerase activity.... Agent: Astrazeneca R&d Boston

20070059752 - Fluorescence energy transfer probes with stabilized conformations: The present invention provides a class of Conformationally Assisted Probes comprising (a) a nucleic acid moiety; (b) an energy donor moiety; (c) an energy acceptor moiety; and (d) one or more stabilizing moieties.... Agent: Morgan, Lewis & Bockius LLP (sf)

20070059705 - Fluorescent magnetic nanoparticles and process of preparation: This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be... Agent: Morrison & Foerster LLP

20070059688 - Gastrointestinal chemosensory receptors: This invention provides isolated nucleic acid and amino acid sequences of gastrointestinal endocrine cell specific G-protein coupled receptors, methods of detecting such receptors, and methods of screening for ligands of such receptors. Furthermore, this invention demonstrates that SrC-1 enteroendocrine cells express multiple bitter taste receptors as well as a-subunits of... Agent: Bozicevic, Field & Francis LLP

20070059737 - Gene expression profiling in biopsied tumor tissues: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon... Agent: Heller Ehrman LLP

20070059708 - Gene screen: We describe a method for the identification of genes which show regulated expression in response to carbon source utilisation, typically genes associated with the initiation and/or promotion of cell transformation from a non-cancerous to a cancerous phenotype, typically of cells found in the colon; the use of these genes in... Agent: Klarquist Sparkman, LLP

20070059710 - Genetic polymorphisms associated with stroke, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with vascular diseases, particularly stroke. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins,... Agent: Celera Genomics Attn: Wayne Montgomery, Vice Pres, Intel Property

20070059703 - Genome mapping of functional dna elements and cellular proteins: The disclosure provides methods of examining the binding of proteins to DNA across a genome (e.g., the entire genome or a portion thereof, such as one or more chromosomes or a chromosome regions). In particular, the disclosure relates to a method of identifying a regulatory region (e.g., a protein or... Agent: Buchanan, Ingersoll & Rooney LLP

20070059759 - Human t2r63 receptor and related assays for identifying human bitter taste modulators: The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R63 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor.... Agent: Hunton & Williams LLP Intellectual Property Department

20070059689 - Hybrid glycosylated products and their production and use: Hybrid glycosylated products such as polyketides and peptides are produced by transforming a host cell with (a) a gene cassette for synthesising an activated sugar and (b) nucleic acid encoding a glycosyltransferase (GT). The cell also produces or is supplied with an aglycone template. At least some of the components... Agent: Klauber & Jackson

20070059693 - Hybridization-based biosensor containing hairpin probes and use thereof: A sensor chip that includes: a fluorescence quenching surface; a nucleic acid probe that contains first and second ends with the first end bound to the fluorescence quenching surface, a first region, and a second region complementary to the first region, the nucleic acid probe having, under appropriate conditions, either... Agent: Nixon Peabody

20070059750 - Identifier and nucleic acid amplification method of verification using the same: There is provided an identification technique that can consistently maintain a set of information specifying a specimen through all the processes from the amplification process to the detection process of a specific sequence. A base sequence incorporating as a set of decodable information an individual code imparted to the specimen... Agent: Fitzpatrick Cella Harper & Scinto

20070059756 - Immunointeractive molecules and their uses in treating subjects suffering from hev b 5 allergies: The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with T lymphocytes in subjects having latex allergy and genetic sequences encoding same. These molecules are preferentially immunointeractive with T cells in subjects having a Hev b 5 allergy. The present invention also extends... Agent: Knobbe Martens Olson & Bear LLP

20070059721 - Magi polynucleotides, polypeptides, and antibodies: MAGI polypeptides, polynucleotides, antibodies, and methods for producing the same by recombinant techniques are disclosed. Also disclosed are methods for utilizing MAGI polypeptides and polynucleotides in diagnostic assays.... Agent: Smithkline Beecham Corporation Corporate Intellectual Property-us, Uw2220

20070059698 - Marks as modifers of the pten pathway and methods of use: Human MARK genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of PTEN, comprising screening for agents that... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20070059706 - Materials and methods relating to breast cancer classification: The inventors set out to identify a set of genes for use as prognostic markers for breast tumours which correlate with the Nottingham Prognostic Index (NPI). Initially they were unable to identify a single set of genes whose expression correlates with the NPI. However after segregating the dataset into molecular... Agent: Dann, Dorfman, Herrell & Skillman

20070059757 - Method and compositions for the treating diseases targeting e-cadherin: Methods and compositions for diagnosing, detecting and treating a pancreatic disease associated with differential expression of E-cadherin in comparison to healthy cells. Also provided are antagonists or agonists of E-cadherin, and methods for screening agents that modulate the E-cadherin level or activity in vivo or in vitro.... Agent: Celera Genomics Attn: Wayne Montgomery, Vice Pres, Intel Property

20070059691 - Method for determining the susceptibility of a subject to infection: A method for determining the susceptibility of a subject to infection, which method comprises: (i) providing a sample from said subject; (ii) detecting any LL-37 present in said sample; (iii) optionally comparing the level of LL-37 in said sample to a control sample; and (iv) determining the susceptibility of said... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070059733 - Method for sequencing nucleic acids by observing the uptake of nucleotides modified with bulky groups: The present methods and apparatus concern nucleic acid sequencing by incorporation of nucleotides into nucleic acid strands. The incorporation of nucleotides is detected by changes in the mass and/or surface stress of the structure. In some embodiments of the invention, the structure comprises one or more nanoscale or microscale cantilevers.... Agent: Raj S. Dave Morrison & Foerster LLP

20070059743 - Method for the design of oligonucleotides for molecular biology techniques: The present invention discloses a method that can be used to identify one DNA sequence or one specific group of DNA sequences from a complex biological sample. Diverse molecular biology methods require the use of short DNA sequences, called oligonucleotides, that are artificially synthesized from a description of their composing... Agent: Merchant & Gould PC

20070059740 - Method of targeting a2b adenosine receptor antagonist therapy: Provided herein are methods for determining if a subject will benefit from A2B receptor antagonist therapy.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20070059700 - Methods and compositions for optimizing multiplex pcr primers: This invention relates generally to the field of PCR. In particular, the invention provides methods, compositions and kits for optimizing multiplex PCR primers using, inter alia, a plurality of 5′ and 3′ specific primers and a 5′ and a 3′ universal primer at various ratios.... Agent: Morrison & Foerster LLP

20070059747 - Methods and probe combinations for detecting melanoma: The present invention is based on the discovery of methods and combinations of probes to chromosomal regions that are gained or lost or imbalanced in melanoma that provide highly specific and sensitive assays for the detection of melanoma cells.... Agent: Townsend And Townsend And Crew, LLP

20070059716 - Methods for detecting fetal abnormality: The invention relates to a method of identifying fetal abnormality from a maternal blood sample by capturing an image of a fetal nucleated red blood cell obtained from the maternal blood sample; inputting probe intensities for a plurality of nucleic acid probes that bind fetal nucleic acids of interest; analyzing... Agent: Wilson Sonsini Goodrich & Rosati

20070059699 - Methods for detecting toxic and non-toxic cyanobacteria: This invention is related to a method for detecting toxic and non-toxic cyanobacteria. The method comprises that nucleic acid from a biological sample is brought into contact with an oligonucleotide designed to be specific for the mcy gene, in particular mcyE and/or mcyD, and with an oligonucleotide designed to be... Agent: John Dodds

20070059707 - Methods for prenatal diagnosis of chromosomal abnormalities: Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal diagnosis of chromosomal abnormalities based on analysis of a maternal blood sample. The invention exploits the differences in DNA between the mother and fetus,... Agent: Ronald I Eisenstein Nixon Peabody

20070059755 - Methods for selective targeting: A selective targeting method is disclosed which comprises contacting a peptide library with an anti-target to allow the peptides to bind; separating non-binding peptides from the anti-target bound peptides, contacting the non-binding anti-target peptides with a target allowing the unbound peptides to bind with the target to form a target-bound... Agent: Genencor International, Inc.

20070059748 - Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer: Described herein are genes whose expression are up-regulated or down-regulated in specific cancers. Related methods and compositions that can be used for diagnosis and treatment of those cancers are disclosed. Also described herein are methods that can be used to identify modulators of selected cancers.... Agent: Pdl Biopharma, Inc.

20070059712 - Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer: Described herein are genes whose expression are up-regulated or down-regulated in prostate cancer. Also described are such genes whose expression is further up-regulated or down-regulated in drug-resistant prostate cancer cells. Related methods and compositions that can be used for diagnosis and treatment of prostate cancer are disclosed. Also described herein... Agent: Fenwick & West LLP

20070059711 - Microarray for evaluation of stress-related genes in skin: The present invention provides a novel DNA microarray chip that can be used for simultaneous testing of transcriptional responses to cutaneous stressors in the context of neuro-endocrine-immune functions of the skin. The transcriptional responses to ultraviolet radiation in epidermal keratinocytes were tested using such microarray chip containing more than 700... Agent: Benjamin Aaron Adler Adler & Associates

20070059760 - Multi-featured arrays with reflective coating: A method and apparatus of interrogating an addressable array unit, which includes a substrate, a light reflecting layer on a front side of the substrate, and a plurality of features on a front side of the array. The method may include, for each of multiple features, illuminating the feature simultaneously... Agent: Agilent Technologies Inc.

20070059730 - Novel 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 nucleic... Agent: Millennium Pharmaceuticals, Inc.

20070059724 - Novel compositions and methods for lymphoma and leukemia: The present invention relates to novel sequences for use in diagnosis and treatment of lymphoma and leukemia. In addition, the present invention describes the use of novel compositions for use in screening methods.... Agent: Sagres Discovery Inc. Intellectual Property - R440

20070059722 - Novel genes and markers associated to type 2 diabetes mellitus: Genes, SNP markers and haplotypes of susceptibility or predisposition to T2D and subdiagnosis of T2D are disclosed. Methods for diagnosis, prediction of clinical course and efficacy of treatments for T2D using polymorphisms in the T2D risk genes are also disclosed. The genes, gene products and agents of the invention are... Agent: Birch Stewart Kolasch & Birch

20070059751 - Nucleic acid isolation method: In a nucleic acid isolation method for a solid biological sample, since two or more kinds of instruments are used for biological sample disruption and nucleic acid isolation, the operations are complicated, thereby increasing the operating labor, prolonging the operation time, and deteriorating the property of a nucleic acid associated... Agent: Mcdermott Will & Emery LLP

20070059749 - Nucleic acid, nucleic acid for detecting chlorinated ethylene-decomposing bacteria, probe, method of detecting chlorinated ethylene-decomposing bacteria, and method of decomposing chlorinated ethylene: Chlorinated ethylene-decomposition bacteria is detected by performing PCR using nucleic acid comprising 18˜25 nucleotides that preferentially hybridizes to the 16S rRNA or rDNA of chlorinated ethylene-decomposing bacteria and has any of base sequences of SEQ ID No. 1˜15, a base sequence that has at least 90% homology with any of... Agent: Darby & Darby P.C.

20070059729 - Nucleic acids and corresponding proteins entitled 282p1g3 useful in treatment and detection of cancer: A novel gene 282P1G3 and its encoded protein, and variants thereof, are described wherein 282P1G3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 282P1G3 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 282P1G3 gene or... Agent: Agensys C/o Morrison & Foerster LLP

20070059687 - Process for evaluating phagocytotic function and use thereof: A digested phagocyte prepared by contacting in vitro a phagocyte with a foreign microorganism and isolating the phagocyte so contacted; a process for producing the same; and a process and a kit in which these are utilized are disclosed. An experimental model, which enables in vitro evaluation of a phagocytotic... Agent: David A. Gass Marshall, Gerstein & Borun

20070059742 - Process of stripping a microarray for reuse: Disclosed herein is a process for stripping oligonucleotide target from a microarray to allow reuse of the microarray. The process comprises providing a microarray having probe oligonucleotides attached thereto and target oligonucleotides hybridized to the probe oligonucleotides. The microarray is then incubated with a formulation comprising an organic solvent and... Agent: Combimatrix Corporation

20070059739 - Pure mirna sample preparation method: The present teachings provide novel methods, compositions, and kits for analyzing mature micro RNAs (miRNAs). By taking advantage of the observation that most mature miRNAs in cells are tightly associated with RISCs, the present teachings provide approaches for studying mature miRNAs without the complications of additional nucleic acids. For example,... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070059715 - Quantitative gene expression profiling: Described herein are approaches to the measurement of gene expression for chosen genes in a biological sample. The methods permit the quantitation of target nucleic acids, e.g., DNAs or RNAs in a nucleic acid sample, both singly and in a multiplex format that permits the determination of levels (e.g., expression... Agent: Edwards Angell Palmer & Dodge LLP

20070059734 - Reagent for detecting biopolymer and method for detecting biopolymer: Detects the presence of binding between a sample biopolymer and a probe biopolymer and the amount of binding, without modifying the sample biopolymer in any way. The present invention provides a reagent for biopolymer detection comprising semiconductor nanoparticles on which a functional group having a positive or negative charge is... Agent: Reed Smith Hazel & Thomas LLP

20070059758 - Regulators of type-1 tumor necrosis factor receptor and other cytokine receptor shedding: The present invention provides compositions and methods for the regulation of cytokine signaling through the Tumor Necrosis Factor (TNF) pathway. Specifically, the invention provides a novel gene, polypeptide and related compositions and methods for the regulation of ectodomain shedding. In preferred embodiments, methods and compositions for the regulation of TNF... Agent: Leydig, Voit & Mayer, Ltd.

20070059720 - Rna expression profile predicting response to tamoxifen in breast cancer patients: The present invention regards predicting a response to a therapy using RNA expression profiling. In particular, a resistance to a chemotherapy, such as tamoxifen, is predicted by comparing expressed genes in a patient on the therapy to a patient sensitive to the chemotherapy. In further embodiments, there is an RNA... Agent: Fulbright & Jaworski L.L.P.

20070059723 - Secreted epithelial colon stromal-1 molecules and uses thereof: The present invention provides novel Secreted Epithelial Colon Stromal-1 (Secs-1) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing Secs-1 polypeptides. The invention further provides methods for the treatment, diagnosis, amelioration, or prevention of diseases associated with... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070059695 - Sgk1 as diagnostic and therapeutic target: The invention relates to the utilization of a substance for diagnostic determination of sgk1 (serum and glucocorticoid dependent kinase 1) and to the utilization of an active agent in order to influence sgk1 for therapeutic treatment of diseases associated with disordered activity of the tissue factor and to a diagnostic... Agent: Millen, White, Zelano & Branigan, P.C.

20070059713 - Ssb-dna polymerase fusion proteins: Fusion proteins comprising a single strand DNA binding protein and a nucleic acid polymerase (e.g. DNA polymerase or reverse transcriptase). These high fidelity proteins are suitable for use in nucleic acid amplification methods, including the polymerase chain reaction (PCR).... Agent: Invitrogen Corporation C/o Intellevate

20070059709 - Staphylococcus aureus antibacterial target genes: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are... Agent: Bingham, Mccutchen LLP

20070059746 - Substance carrier using hollow nanoparticle of hepatitis b virus protein and liposome, and method of introducing substance into cell: The present invention relates to a method of producing a composite particle of a nanoparticle and a liposome in which a substance to be introduced has been encapsulated, characterized in that a hollow nanoparticle containing a hepatitis B virus protein or a modification thereof is fused to the liposome in... Agent: Knobbe Martens Olson & Bear LLP

20070059717 - Systemic lupus erythematosus diagnostic assay: The present invention provides compositions and methods for aiding in the diagnosis, monitoring and prognosis of SLE in a subject and for identifying potential therapeutic agents to treat and/or ameliorate the symptoms associated with SLE. Accordingly, embodiments of the invention are directed to methods of identifying the gene expression profile... Agent: Chalker Flores, LLP

20070059718 - Systems and methods for enrichment of analytes: The present invention relates to methods for detecting and concentrating minute amounts of biohazard analytes, including but not limited to bacteria, protozoa, viral pathogens, and toxins, in environmental and other samples. These analytes can be substantially enriched by the methods of the invention, and further, a second analyte can be... Agent: Wilson Sonsini Goodrich & Rosati

20070059754 - Systems and methods for fluorescence detection with a movable detection module: A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler and a detection module movably mountable on the support structure. The detection module... Agent: Townsend And Townsend And Crew, LLP

20070059731 - Ubiquitin mediated fluorescence complementation assay: The present invention relates to methods and compositions for identifying covalent joining or modification of proteins. In particular, the present invention relates to covalent fluorescence complementation assays for the detection of modified (e.g., ubiquitinated proteins). The present invention further relates to the use of such fluorescence complementation assays in drug... Agent: Medlen & Carroll, LLP

20070059768 - Broad host range vectors for shotgun and expression library cloning in gram negative bacteria: The present invention concerns methods and compositions for the construction of a series of stable vectors for genomic library construction useful in Gram negative species. In certain embodiments, the vectors contain the pBBR1 replicon, capable of to stable replication in a broad range of Gram negative species. In various embodiments,... Agent: Faegre & Benson LLP Patent Docketing

20070059763 - Cellomics system: In labeling a cell, and separating and collecting the cell according to a degree of the labeling using a cell separator, effects on the cell is minimized and the use of the collected cell is facilitated, thereby, when labeling a cell, the cell is labeled in the state where interaction... Agent: Antonelli, Terry, Stout & Kraus, LLP

20070059764 - Electrospray coating of aerosols for labeling and identification: A device having an air sampler, an electrospray apparatus, and a fluorescence excitation and detection system. The air sampler is capable of moving air suspected of containing a biological or chemical aerosol particle into a chamber. The electrospray apparatus is capable of spraying a charged solution into the chamber to... Agent: Naval Research Laboratory Associate Counsel (patents)

20070059769 - High throughput glycan microarrays: The invention provides arrays of glycans for detecting entities that bind to glycans. In some embodiments, the arrays can be used to detect disease, blood types, antibodies, bacterial or viral infection, cancer, and the like. The invention also provides methods and kits for such detection. In another embodiment, the invention... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20070059762 - Insulin resistance curative and method of screening the same: The present invention provides a screening method for a compound which is highly safe and has a prophylactic or therapeutic effect on diabetes, and a highly safe pharmaceutical composition for the prophylaxis or treatment of diabetes. Specifically, a drug for the prophylaxis or treatment of diabetes, which contains, as an... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070059765 - Liposome-based microarray and methods of use thereof: This invention provides novel liposome-based articles of manufacture and microarrays and methods of making and using them (1) to detect the presence of one or more agents in a sample, (2) to determine the amount of one or more agents in a sample, and (3) to determine whether a subject... Agent: Cooper & Dunham, LLP

20070059767 - Method of identifying n-terminal probnp: The invention relates to a method of identifying N-terminal proBNP in a sample with at least two antibodies that detect different epitopes of the N-terminal proBNP. The method is used to differentiate or classify samples of healthy individuals and samples of patients of NYHA classes I to IV. The invention... Agent: Brinks Hofer Gilson & Lione

20070059766 - Mixture of binding proteins: Described are methods for producing libraries of cells expressing at least two separate single polypeptide chain binding proteins, in which the binding proteins have different target epitopes. Such libraries are made by integration of the nucleic acid sequences encoding the polypeptide chains into the genome of the host cell, and... Agent: Trask Britt

20070059772 - Phosphorylated glyoxalase i and its use: The present invention relates to a phosphorylated form of mammalian glyoxalase I. The present invention relates further to the use of phosphorylated mammalian glyoxalase I to modulate MG-modification of proteins (AGE formation) and consequent cell death, especially upon stress such as oxidative stress, or upon TNF treatment.... Agent: Trask Britt

20070059771 - Protein o-sulfonation: Post-translational O-sulfonation of a serine or threonine residue of proteins is detected, optionally comparatively, wherein the detected O-sulfonation is detected under a first physiological condition, and is compared with a control O-sulfonation detected under a second physiological condition, and a difference between the detected and control O-sulfonations indicates a difference... Agent: Richard Aron Osman Science And Technology Law Group

20070059770 - Reference database: Data acquisition and cataloging are used to classify polypeptides into a reference index or database. The database can be used to identify previously unidentified samples. New polypeptides are characterized and added to the database.... Agent: Large Scale Biology Corporation

20070059761 - Storage and use of colloids: The present invention discloses compositions and methods for enabling the longterm storage and/or use of colloid particles without substantial degradation of their performance, for example, by chemical or physical degradation, by particle aggregation, changes in pH and/or relative humidity, changes in salt concentration, and/or by a decrease in the binding... Agent: Jhk Law

20070059779 - Biocatalytic solgel microarrays: A system and method for conducting high-throughput interactions between test compositions and analytes, comprising one or more test compositions, and a plurality of independent micromatrices, wherein each said micromatrix encapsulates at least one said test composition; and said micromatrices are made of a material that is permeable to an analyte.... Agent: Elmore Patent Law Group, PC

20070059773 - Identification of therapeutic compounds: Methods for identifying potential therapeutic agents involve determining the affinity and/or efficacy of a test compound for an adensoine receptor at a relatively high pH and at a relatively low pH. Compounds with greater affinity and/or efficacy at the low pH are identified as potential therapeutic agents, in particular for... Agent: Fish & Richardson PC

20070059774 - Kits for prenatal testing: The invention relates to a kit for prenatal testing comprising a size-based separation module which enriches a first cell type from a maternal blood sample found in vivo in a pregnant female at a concentration of less than 1% of all blood cells, and a set of instructions for analyzing... Agent: Wilson Sonsini Goodrich & Rosati

20070059776 - Methods for monitoring polypeptide production and purification using surface enhanced laser desorption/ionization mass spectrometry: The invention provides methods of monitoring the production of a target polypeptide by generating surface enhanced laser desorption/ionization mass spectral profiles of samples taken from multiple cell culture batches or of samples taken at different times from a given batch. The invention additionally provides methods for monitoring the purification of... Agent: Quine Intellectual Property Law Group, P.C.

20070059778 - Modified colony assay: Improved colony forming cell (CFC) assays are described. The improved assay comprises modifications to the standard CFC assay that enable analysis of temporal, real-time changes in antigen expression during colony development without need to fixate or destroy the culture. The improved assay is applicable to hematopoietic CFC assays as well... Agent: Bereskin And Parr

20070059775 - Synthesis and conjugation of iron oxide nanoparticles to antibodies for targeting specific cells using fluorescence and mr imaging techniques: The invention provides for methods for producing water-soluble iron oxide nanoparticles comprising encapsulating the nanoparticles in phospholipids micelles. Also provided are methods for conjugating the inventive nanoparticles via functionalized phospholipids to a target molecule, such as an antibody. The invention further provides methods for using the nanoparticle-antibody conjugate of the... Agent: Wilmerhale/columbia University

20070059777 - Thrombin-induced fibrinogen binding for the detection of risk of bleeding disorders: This invention provides a methods of detecting a bleeding disorder in mammals where the bleeding disorder is characterized by normal fibrinogen binding to ADP-activated platelets, but decreased fibrinogen binding to thrombin-activates platelets.... Agent: Townsend And Townsend And Crew, LLP

20070059782 - Magnetic particle tagged blood bank reagents and techniques: Magnets and magnetic particle-labeled reagents are used to capture and/or release magnetic particle-tagged entities for immunohematology diagnostic testing purposes, especially tests performed in blood banking. The magnetic tagged entities may be tagged antibodies, tagged blood cells, tagged universal binding partners, especially tagged lectins and tagged Coombs reagent, and other binding... Agent: Ralph T. Lilore Attorney At Law

20070059781 - System for size based separation and analysis: The invention relates to one or more size-based separation modules adapted to increase a concentration of a first analyte in a sample by at least 10,000 fold, wherein said first analyte has an initial concentration in said sample of less than 1×10−3 analytes/μL, and an analyzer for analyzing said first... Agent: Wilson Sonsini Goodrich & Rosati

20070059785 - Biomarkers in cancer: Biomarkers may be used in the treatment of cancer, and as an aid in clinical decision making regarding which anti-cancer therapy to use in a particular patient. Described herein are methods of assessing whether a subject with a solid tumor is suitable for treatment with a dual EGFR/erbB2 tyrosine kinase... Agent: Glaxosmithkline Corporate Intellectual Property, Mai B475

20070059783 - Method of identifying markers diagnostic of disease and uses therefor in the diagnosis of cancer: This invention provides methods for the diagnosis of cancer by identifying novel glycans that are diagnostic of cancerous cells or tumors in an human or animal subject, and methods for identifying markers of disease states in humans and/or animals using mass spectrometry on partially purified glycan-containing samples.... Agent: Fenwick & West LLP

20070059784 - Methods for measuring the insulin receptor alpha subunit: Presence of free insulin receptor α-subunit in blood was discovered. Furthermore, methods for measuring the insulin receptor α-subunit was provided, the method comprising the steps of contacting the insulin receptor α-subunit in a blood sample with an antibody recognizing the insulin receptor α-subunit, and detecting the binding between the two.... Agent: Townsend And Townsend And Crew, LLP

20070059780 - Detection and amplification of ligands: A system for the detection of ligands comprising at least one receptor and an amplification mechanism coupled to the receptor wherein an amplified signal is produced as a result of receptor binding a ligand. Examples of suitable amplification mechanisms include antibody-embedded liquid crystalline materials; use of alpha-2-macroglobulin to encage an... Agent: Hahn Loeser & Parks, LLP

20070059786 - Chemiluminescence enhancer: The present invention provides a chemiluminescence enhancer treated to retain favorable dispersibility of fine solid carriers and stably exert a chemiluminescence enhancing action. The invention provides a chemiluminescence enhancer used for signal detection in a solid phase immunoassay using antigen or/and antibody immobilized onto fine solid carriers dispersible in a... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070059787 - Kinase and phosphatase assays: Compositions, methods, and kits for detecting and monitoring kinase, phosphatase and protein post-translational modification activity are described. The compositions typically include a peptide, a detectable moiety, and a protease cleavage site. Modification of a peptide by a kinase, phosphatase or other protein post-translational modification alters the proteolytic sensitivity of the... Agent: Invitrogen Corporation C/o Intellevate

20070059788 - Method and apparatus for electrically detecting an adverse effect of a toxic substance on procaryotic cells: A method and apparatus for electrically measuring an adverse effect of toxic substances on prokaryotic cells includes measuring a whole intracellular change caused by the presence of toxic substances as a change in an electric signal of cell membranes of the prokaryotic cells. According to the present invention, it is... Agent: Cantor Colburn, LLP

20070059789 - Process for the enzymatic synthesis of ethers: An enzymatic process for preparing ethers is disclosed which includes reacting one or more alcohols with an ether in the presence of at least one enzyme.... Agent: Leopold Presser Scully, Scott, Murphy & Presser

20070059790 - Method to increase carotenoid production in a microbial host cell by down-regulating glycogen synthase: A method to increase carotenoid production in carotenogenic microbial host cells is provided by down-regulating or disrupting glycogen synthesis. Disruption of glycogen synthase activity in a carotenogenic microbial host cell significantly increased carotenoid production. Carotenogenic microorganisms are also provided that have been optimized for the production of carotenoid compounds through... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070059796 - Binding motif and methods of regulating cell function: The present invention relates to a binding motif and methods of regulating cell function which methods target a single amino acid residue preferably a Tyr in a binding motif equivalent to a motif of the common beta chain (βc) of the GM-CSF/IL-3/IL-5 receptor. Preferably, the cell functions affect cell survival... Agent: Darby & Darby P.C.

20070059794 - Chaperonin-target protein complex, method of producing the same, method of stabilizing target protein, method of immobilizing target protein, method of analyzing the structure of target protein, sustained-release formulation, and method of producing antib: The present invention provides a chaperonin-target protein complex and a method of producing the same, and a method of stabilizing the target protein, a method of immobilizing the target protein, a method of analyzing the structure of the target protein, a sustained-release formulation, and a method of producing an antibody... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070059795 - Engineered zinc finger proteins for regulation of gene expression: Disclosed herein are methods and compositions for modulation of gene expression, with single-gene specificity, in a human-sized genome.... Agent: Robins & Pasternak

20070059799 - Inducing cellular immune responses to hepatitis b virus using peptide and nucleic acid compositions: This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to develop epitope-based vaccines directed towards HBV. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of HBV infection.... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.

20070059793 - Nogo receptor binding protein: The invention provides Sp35 polypeptides and fusion proteins thereof, Sp35 antibodies and antigen-binding fragments thereof and nucleic acids encoding the same. The invention also provides compositions comprising, and methods for making and using, such Sp35 antibodies, antigen-binding fragments thereof, Sp35 polypeptides and fusion proteins thereof.... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.

20070059800 - Novel peptide, novel adsorbent, adsorption unit and adsorption method: The present invention provides an adsorbent, adsorption unit, and an adsorption method which make it possible to selectively adsorb an immunoglobulin and/or an immune complex present in a body fluid (for example, blood, plasma, etc.) efficiently without pretreating the body fluid. By immobilizing a compound having binding activity for an... Agent: Kenyon & Kenyon LLP

20070059798 - Polypeptides useful for molecular weight determinations: The invention also provides a process for preparing a composition comprising: preparing a mixture of polypeptides, wherein each polypeptide in the mixture (a) is a copolymer of the amino acids L-alanine, L-glutamic acid, L-tyrosine and L-lysine, and (b) may be present in the form of a pharmaceutically acceptable salt; and... Agent: Cooper & Dunham, LLP

20070059792 - Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation: The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously... Agent: Townsend And Townsend And Crew, LLP

20070059791 - Preparation of vaccines using a photosensitizer and light: Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but... Agent: Gambro, Inc Patent Department

20070059797 - Upstream control elements of the proopiomelanocortin gene and their use: The nucleic acid sequence of the POMC enhancer is disclosed herein. Sequences from the human, rat, rabbit, hamster, mouse, and cow POMC enhancer are disclosed. Hybrid transgenes, comprising a POMC transcriptional control element operably linked to a nucleic acid sequence encoding a marker are also enclosed. In addition, transgenic mice... Agent: Klarquist Sparkman, LLP

20070059801 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070059802 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070059804 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070059803 - Mammalian cytokines; related reagents and methods: Purified genes encoding cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Dnax Research Inc. Legal Department

20070059805 - Method for producing saccharide chain-extended chondroition: A vector of the present invention has DNA encoding a protein or a product having the same effect as the protein, the protein containing an amino acid sequence from amino acid numbers 47 to 802 in SEQ. ID. NO:2. Expression of the DNA gives human chondroitin synthase. By using human... Agent: Kubovcik & Kubovcik

20070059808 - Compositions and methods for inhibiting white spot syndrome virus (wssv) infection: The present invention relates to a novel composition useful for inhibiting White Spot Syndrome Virus (WSSV) infection of crustacean animals, particularly those of the genera Penaeus sp. More specifically, the novel composition comprises a polypeptide whose amino acid sequence corresponds to at least a portion of Vp28, a surface protein... Agent: Townsend And Townsend And Crew, LLP

20070059807 - Mucosal immunization to prevent prion infection: Vaccines against prion disease eliciting a humoral immune response when administered mucosally are described. The vaccines comprise a prion protein, a prion protein fragment, or a non-amyloidogenic prion protein homolog and an adjuvant suitable for inducing a humoral immune response after mucosal administration. Suitable adjuvants include cholera toxin subunit B,... Agent: Darby & Darby P.C.

20070059806 - Nucleic acid molecules, polypeptides, antibodies and compositions containing same useful for treating and detecting influenza virus infection: Polynucleotides and polypeptides which participate in influenza virus infection of cells and nucleic acid molecules, which include a polynucleotide sequence capable of specifically binding the polypeptides of the present invention. Also provided are methods of using such nucleic acid molecules, polynucleotides and antibodies directed thereagainst for diagnosing, treating and preventing... Agent: Martin Moynihan Anthony Castorina

20070059809 - Corynebacterium glutamicum genes encoding regulatory proteins: Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070059810 - Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins: Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070059811 - Uncoupled productive and catabolic host cell pathways: The invention provides methods for producing products comprising improved host cells genetically engineered to have uncoupled productive and catabolic pathways. In particular, the present invention provides host cells having a modification in nucleic acid encoding an endogenous enzymatic activity that phosphorylates D-glucose at its 6th carbon and/or a modification of... Agent: Genencor International, Inc.

20070059812 - Process for making fluoroleucine ethyl esters: The instant invention describes a novel reaction that includes spontaneous racemization of an azalactone via enol tautomerization. This racemization results in improved yield and ee over other reactions previously described.... Agent: Merck And Co., Inc

20070059813 - Recovery method for immobilized biocatalysts: Processes for the production of a product by the enzymatic treatment of a soluble or particulate substrate with a particulate, immobilized enzyme, by treating a process liquor containing the substrate in a bioreactor to produce a slurry of effluent immobilized enzyme and the product in an effluent liquor. The slurry... Agent: Fitch, Even, Tabin & Flannery

20070059814 - Hypoxia-inducible protein 2 (hig2), a novel therapeutic potential target of renal cell carcinoma (rcc): The present invention provides a method for inhibiting growth of a cancer cell, particularly a renal cell carcinoma, by contacting the cell with a composition composed of an HIG2 siRNA or HIG2 antibody. Methods of diagnosing renal cell cancer are also provided within the present invention.... Agent: Townsend And Townsend And Crew, LLP

20070059815 - Odor control methods and compositions: This invention is directed generally to methods of controlling the odor of a biological material, and more particularly to methods comprising providing the biological material with an Fe(III)-reducing bacteria and a source of Fe(III). This invention also is directed generally to compositions and kits for controlling the odor of a... Agent: Bryan K. Wheelock

20070059816 - Apparatus for producing tissue arrays: An apparatus for producing a tissue array, having at least one receiver block (1) and at least one donor block (2) that comprises tissue (3) to be investigated, is described. The donor block (2) comprises tissue (3) to be investigated, a first hollow needle (4) for creating a cavity in... Agent: Hodgson Russ LLP

20070059817 - Biochemical reaction cassette with improved liquid filling performance: A biochemical reaction cassette comprises a housing member, a reaction chamber arranged in the housing member and having a bottom section and a ceiling facing the bottom section, an injection port arranged at the ceiling of the reaction chamber, a discharge port arranged at the ceiling of the reaction chamber... Agent: Fitzpatrick Cella Harper & Scinto

20070059818 - Petri dish for trapping cell: A petri dish that includes a cell trapping portion having a plurality of suction holes. A cell-contained liquid is placed in the petri dish and the cell-contained liquid is sucked from the suction holes, which are smaller that the cells, from below the petri dish to trap the cells in... Agent: Staas & Halsey LLP

20070059819 - Compost tea brewer: An apparatus for brewing compost tea from an aqueous compost mixture using only air bubbles as a means to circulate the mixture during fermentation. The mixture is held in a tank having a continuous sidewall and a conical bottom section with a central discharge opening. A plurality of equidistant conduits... Agent: William J. Mason Maccord Mason PLLC

20070059820 - Methods to express recombinant proteins from lentiviral vectors: Lentivector constructs for expression of recombinant proteins, polypeptides or fragments thereof and methods of making the same are described. The lentivectors typically have a self-processing cleavage sequence between a first and second protein or polypeptide coding sequence allowing for expression of a functional protein or polypeptide under operative control of... Agent: Dla Piper Rudnick Gray Cary LLP

20070059821 - Method for preparing cell cultures from biological specimens for chemotherapeutic and other assays: An improved method for preparing a cell culture is disclosed. The method includes culturing a multicellular tissue explant in the presence of growth medium that is substantially free of enzymes capable of digesting the explant and, subsequently, removing the explant at a predetermined time.... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070059822 - Method for isolating cells from mammary secretion: The present invention relates to a method for isolating progenitor cells from a human body, inclusive of all cells with stem cell-like characteristics, in particular pluripotent or multipotent progenitor cells, wherein such cells are directly or indirectly derived from human mammary secretion, be it colostrum, mature milk, or dry period... Agent: Michael H Baniak Baniak Pine & Gannon

20070059823 - Neuronal differentiation of stem cells: The present invention relates to compositions and methods for culturing stem cells, such that neuronal differentiation can be achieved.... Agent: William F Lawrence Frommer Lawrence & Haug

20070059825 - Cytokine zalpha11 ligand antibodies: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller... Agent: Zymogenetics, Inc. Intellectual Property Department

20070059824 - Human umbilical cord blood-derived pluripotent fibroblast-like-macrophages: The present invention relates to a purified population of fibroblast-like macrophage (f-macrophage, f-MΦ) and methods using the same. The f-MΦ can be expanded in vitro and differentiated into several lineages, including insulin-expressing cells, endothelial cells, and neuronal cells. The f-MΦ described herein have been generated from human umbilical cord blood... Agent: Todd S. Parkhurst Holland & Knight LLP

20070059826 - method to preserve cells: Methods are disclosed that provide for the preservation of living human and other cells at room temperature or higher temperatures which can be applied to research, medical and defense applications. These methods represent a significant improvement relative to currently used methods that employ preservation at cryogenic temperatures. Using these methods,... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070059827 - Device for the regeneration of tissue, specifically bone regeneration by means of callus distraction: The device incorporates a structurally stable membrane (4, 4′, 34, 35) that incorporates a surface (15) to be bonded to a tissue to be regenerated, specifically a vital bone (2, 22, 38, 39). Means (9, 5, 6, 25, 36) are additionally provided whereby the membrane (4, 4′, 24, 35) is... Agent: Browdy And Neimark, P.l.l.c. Attorneys At Law

20070059828 - Carrier for nucleic acid molecule delivery: A carrier for nucleic acid molecule delivery formed from a saccharified copolymer comprising repeating unit (A) having a cationic group, saccharified repeating unit (B). There is further provided a carrier for nucleic acid molecule delivery formed from a saccharified copolymer comprising, in addition to the repeating units (A) and (B),... Agent: Fish & Richardson P.C.

20070059829 - Cristin/r-spondin ligands active in the wnt signaling pathway and methods, compositions and kits relating thereto: The present invention relates to compositions and method for the modulation of Wnt pathway signaling. The Wnt signaling pathway is instrumental in the regulation of cell proliferation, differentiation and morphogenesis.... Agent: Kevin Farrell Pierce Atwood

20070059830 - Method for creating myeloid cell lines: The methods and compositions of the present invention find use in modulating myeloid cell development, particularly differentiation and proliferation. The compositions of the invention include isolated transgenic cells, transgenic tissue, transgenic animals, and transgenic mice. The methods allow generation of myeloid cell lines suitable for tissue culture. Further the invention... Agent: Taft, Stettinius & Hollister LLP

20070059831 - Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in... Agent: Kenyon & Kenyon LLP

20070059832 - Method of introducing nucelic acid: The present invention relates to a method of introducing nucleic acids into cells by electroporation, comprising the step (A) of loading nucleic acids to the surface of an electrode; the step (B) of adhering cells on the obtained nucleic acid-loaded electrode surface; and the step (C) of applying electric pulses... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070059833 - Use of nucleases to improve viability and enhance transgene expression in transfected cells: The present invention concerns methods and compositions for improving viability and transgene expression in transfected cells. In one embodiment, the present invention provides a method for increasing the viability of a transfected cell, the method comprising: transfecting a cell with a nucleic acid sequence; and contacting the transfected cell with... Agent: Fulbright & Jaworski L.L.P.

20070059834 - Method for treating small volumes with electrical current: Disclosed is a method for treating biological material via electrical current, in which the biological material is added to a small volume of a buffer solution having relative high ionic strength. A strong electrical field is generated in the buffer solution by a high voltage pulse having a preset duration.... Agent: Joyce Von Natzmer Hall, Vande Sande & Pequigot, LLP

20070059835 - Ocular gene therapy using avalanche-mediated transfection: The present invention provides a method of treating an ocular disease in a subject. In a first step, a nucleic acid is introduced into cells or a tissue. The nucleic acid is introduced by electron avalanche transfection. With this technique, a high electric field induces a vapor bubble and plasma... Agent: Lumen Intellectual Property Services, Inc.

20070059836 - Compositions and methods for regulating genes of interest: Compositions and methods for regulating genes of interest are provided. The compositions comprise sense-antisense double stranded nucleic acid molecules, which have homology to a target nucleic acid sequence in a cell. The compositions and methods are useful for the treatment of disease and for preventing the proliferation of neoplastic cells.... Agent: C. Allen Black, Jr.

20070054258 - Method of removing mucus and cell treatment solution and preservative solution used therefor: Mucus can be removed from cell surfaces so as to enable immunochemical labeling by bringing a cell treatment solution containing cysteine and/or a compound derived therefrom in an amount of 5 mass % or more into contact with a cell specimen containing mucus producing cells, such as uterine cervix cells.... Agent: Sughrue Mion, Pllc

20070054261 - Methods for retail measurement of skin moisture content: Methods provide for measuring scalp moisture content of a consumer. More particularly, the present invention is directed to a method comprising the steps of: (a) collecting input information from said consumer regarding a plurality of characteristics associated with hair and scalp condition of said consumer; (b) providing a moisture meter... Agent: The Procter & Gamble Company Intellectual Property Division

20070054259 - Modulation of hnrnp h and treatment of dm1: The present invention is directed to the discovery that the heterogeneous nuclear ribonucleprotein H (hnRNP H) is capable of binding mutant myotonic dystrophy (DM) protein kinase (DMPK) mRNA. The present invention is also directed to the discovery that modulation of the expression of hnRNP H results in reduced nuclear retention... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20070054260 - Pharmacodynamic assays: The invention provides methods for quickly and easily screening mixed cell samples for a pharmacodynamic effect to a drug or test agent.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.a.

20070054263 - Method and kit for molecular identification of smallpox: We have developed two new PCR based assays to detect Orthopoxvirus DNA which when tested under simulated clinical conditions, have proven to be very sensitive, rapid and robust. Importantly, we were able to construct artificial templates for use as positive controls in the RFLP analysis necessary to differentiate variola and... Agent: Ade & Company

20070054264 - Methods and means relating to hepatitis b infection: The present inventors have discovered that the presence of antibodies reactive with residues 94-117 of the PreS1 component of the hepatitis B surface antigen (HBsAg) in an individual with HBV infection correlates closely with the effectiveness of interferon (IFN) in treating the individual. Methods and means based on this finding... Agent: Nixon & Vanderhye, Pc

20070054262 - Methods of identifying optimal variants of peptide epitopes: The present invention is directed to methods for selecting a variant of a peptide epitope which induces a CTL response against another variant(s) of the peptide epitope, by determining whether the variant comprises only conserved residues, as defined herein, at non-anchor positions in comparison to the other variant(s). The present... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.

20070054314 - Adiponectin receptor and gene encoding the same: The object is to isolate and identify human and mouse adiponectin receptors, to provide a novel protein having adiponectin binding ability, and to provide a screening method and screening kit for a ligand, agonist and antagonist to an adiponectin receptor using such protein. To achieve this object, a protein is... Agent: Lahive & Cockfield, LLP

20070054311 - Amplification and analysis of whole genome and whole transcriptome libraries generated by a dna polymerization process: The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library... Agent: Fulbright & Jaworski L.l.p.

20070054299 - Apparatus for active programmable matrix devices: A system for performing molecular biological diagnosis, analysis and multistep and multiplex reactions utilizes a selfaddressable, selfassembling microelectronic system for actively carrying out controlled reactions in microscopic formats. Preferably, a fluidic system flow a sample across an active area of the biochip, increasing diagnostic efficiency. Preferably, the fluidic system includes... Agent: O'melveny & Myers LLP

20070054286 - Arrays of nucleic acid probes for analyzing biotransformation genes: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the biotransformation genes, such as cytochromes P450. For example, one such array comprises four probe sets. A first probe set comprises a plurality of probes, each probe comprising a segment of at least three... Agent: Affymetrix Inc/ Attn: Chief Ip Counsel Legal Dept

20070054292 - Bacteriophage linked immunosorbent assay for rapid, sensitive detection of multiple analytes: The invention is a method for the development of a platform that enables the efficient and simultaneous creation of multiple detection assays. The invention entails the use of any bacteriophage, modified to carry a reporter gene, to which any analyte-recognizing moiety is attached via the capsid. The modified bacteriophage is... Agent: Davis, Brown, Koehn, Shors & Roberts, P.c. The Financial Center

20070054266 - Chemical sensor system: A chemical sensor utilizing a chemical receptor (for example, one stimulating the sense of taste or smell) is provided. More specifically speaking, such a receptor is introduced into cells and the cells are immobilized on a support to form a chip. This chip is then employed as a component of... Agent: Seed Intellectual Property Law Group Pllc

20070054304 - Compositions and methods for detection and isolation of phosphorylated molecules: The present invention relates to phosphate-binding compounds that find use in binding, detecting and isolating phosphorylated target molecules including the subsequent identification of target molecules that interact with phosphorylated target molecules or molecules capable of being phosphorylated. A binding solution is provide that comprises a phosphate-binding compound, an acid and... Agent: Invitrogen Corporation C/o Intellevate

20070054281 - Compositions and methods relating to osteoarthritis: Described are compositions and methods related to the identification, selection and use of biomarkers which demonstrate particular advantage in identifying individuals having osteoarthritis. Also described are compositions and methods related to the identification, selection and use of biomarkers which demonstrate particular advantage in identifying individuals having a particular stage of... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070054277 - Computer-directed assembly of a polynucleotide encoding a target polypeptide: The present invention outlines a novel approach to utilizing the results of genomic sequence information by computer-directed polynucleotide assembly based upon information available in databases such as the human genome database. Specifically, the present invention may be used to select, synthesize and assemble a novel, synthetic target polynucleotide sequence encoding... Agent: Philip S. Johnson Johnson & Johnson

20070054294 - Cotton event pv-ghgt07(1445) and compositions and methods for detection thereof: The present invention provides DNA compositions and assays for detecting the presence of the DNA compositions in PV-GHGT07(1445) cotton event based on the DNA sequence of the recombinant construct inserted into the cotton genome and of the genomic sequences flanking the insertion site. Kits and conditions useful in conducting the... Agent: Howrey LLP

20070054305 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the... Agent: Nixon Peabody LLP - Patent Group

20070054306 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the... Agent: Nixon Peabody LLP - Patent Group

20070054283 - Dna sequencing method using step by step reaction: The present invention provides an inexpensive DNA sequencing method with high-sensitivity. The method of the present invention comprising the steps of, adding an given amount of dATP for step by step complementary strand synthesis and subtracting the background luminescence intensity caused by dATP from the measured luminescence intensity to obtain... Agent: Stanley P. Fisher Reed Smith LLP

20070054303 - Expression vectors and methods: Vectors and methods for efficient isolation of recombinant cells expressing high levels of a desired protein are provided. The vectors comprise an amplifiable selectable gene, a fluorescent protein gene, and a gene encoding a desired product in a manner that optimizes transcriptional and translational linkage.... Agent: Genentech, Inc.

20070054308 - Fluorescence polarization assay: The present invention relates to methods for detecting the presence of one or more analytes of interest in a sample by measuring changes in fluorescence anisotropy as a result of binding of the analytes to specific aptamers. The aptamers are immobilized on a solid support and may be in the... Agent: Knobbe Martens Olson & Bear LLP

20070054295 - Gc tag-modified bisulfite genomic dna sequencing for continuous methylation spectra: The present invention relates to a tag-modified bisulfite genomic sequencing (tBGS) method developed for simplified evaluation of DNA methylation sites. The method employs direct cycle sequencing of PCR products at kilobase scale, without conventional DNA fragment cloning. The method entails subjecting bisulfite-modified genomic DNA to a second-round PCR amplification employing... Agent: Heslin Rothenberg Farley & Mesiti Pc

20070054271 - Gene expression in breast cancer: The invention features nucleic acids encoding proteins that are expressed at a higher or a lower level in breast cancer cells than in normal breast cells or in a cell of one grade or stage of breast cancer than in a cell of another grade or stage of breast cancer.... Agent: Fish & Richardson Pc

20070054274 - Gene modulation by rb2/p130 expression: The present invention discloses a set of molecular signatures modulated by RB2/p130 for lung cancer cells and a method of determining whether to use a RB2/p130 gene expression system or a protein encoded by the system to modulate a gene or gene expression pattern in lung cancer cells of mammals.... Agent: Reed Smith LLP

20070054290 - Hedgehog interacting proteins and uses related thereto: The present invention concerns the discovery of a new family of hedgehog binding proteins, referred to herein as “hedgehog interacting proteins” or “HIPs”, which are demonstrated to bind to hedgehog polypeptides with high affinity. As described herein, the vertebrate HIP proteins exhibit spatially and temporally restricted expression domains indicative of... Agent: Fish & Neave Ip Group Ropes & Gray LLP

20070054280 - High throughput optical micro-array reader capable of variable pitch and spot size array processing for genomics and proteomics: An optical micro-array reader system includes microchip, VCSEL, microlens and detector arrays. The microchip array includes multiple sample spots to be separately analyzed. The VCSEL array is disposed to simultaneously illuminate more than one of the multiple spots. The microlens array focuses fluorescences or other optical emissions from the sample... Agent: Dla Piper Us LLP

20070054312 - Human transmembrane proteins: The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.... Agent: Foley And Lardner LLP Suite 500

20070054289 - Identification of genes involved in fertility, ovarian function and/or fetal/newborn viability: A genetic means of determining whether a female subject produces “pregnancy competent” oocytes is provided. The means comprises detecting the level of expression of one or more genes that are expressed at characteristic levels (upregulated or downregulated) in cumulus cells derived from pregnancy competent oocytes. This characteristic gene expression level,... Agent: Hunton & Williams LLP Intellectual Property Department

20070054297 - Mammalian relaxin receptors: High affinity relaxin receptors, polypeptide compositions related thereto, as well as nucleotide compositions encoding the same, are provided. These proteins, herein termed LGR7 and LGR8, are orphan leucine-repeat-containing, G protein-coupled receptors. These receptors have a wide and a unique tissue expression pattern. The receptors, particularly soluble fragments thereof, are useful... Agent: Bozicevic, Field & Francis LLP

20070054275 - Method evolved for recognition of thrombophilia (mert): Methods for predicting an individual's genetic risk for developing venous thrombosis in diverse ethnic populations is disclosed, as are arrays and kits which can be used to practice the method. The method includes screening for mutations, polymorphisms, or both, in at least eight venous thrombosis-related molecules, such as antithrombin III,... Agent: Klarquist Sparkman, LLP

20070054287 - Method for identifying medically important cell populations using micro rna as tissue specific biomarkers: The present teachings provide methods for diagnosing biological conditions, including cancer. In some embodiments, a test sample is collected from a subject such as a clinical patient, wherein the test sample comprises background tissue and may or may not contain cells from a tissue of interest. Observation of a target... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070054285 - Method for isolating nucleic acids: Described herein is a method in which genomic nucleic acid of a cell can be separated from nucleic acid having a molecular weight that is lower than the molecular weight of the genomic nucleic acid (e.g., plasmid DNA) of the cell directly from a cell growth culture. Also described herein,... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20070054282 - Method for the detection of gene transcripts in blood and uses thereof: The present invention relates generally to the identification of biomarkers of conditions including disease and non disease conditions as well as identifying compositions of biomarkers. The invention further provides a method of diagnosing disease, monitoring disease progression, and differentially diagnosing disease. The invention further provides for kits useful in diagnosing,... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070054300 - Method for the identification and quantification of microorganisms useful in biomining processes: The method comprises performing a two-stage PCR known as nested PCR, where in the first stage, called primary PCR, 16S ribosomal DNA sequences (nucleotides 27 to 1492, with E. coli rDNA numbering) are amplified using universal primers for the Bacteria and Archaea kingdoms. In the second stage, these primary amplicons... Agent: Merchant & Gould Pc

20070054272 - Method of preparing dna fragments by selective fragmentation of nucleic acids and applications thereof: The invention relates to a method of preparing DNA fragments by selective fragmentation of nucleic acid fragments. The inventive method comprises a first selection step involving selection of short fragments, consisting in: a) preparing first double-stranded DNA fragments F1 using at least one restriction enzyme E1 which can randomly fragment... Agent: Lowe Hauptman Berner, LLP

20070054298 - Methods for enzyme-mediated coupling of oligomers: The present invention is directed to a method for synthesizing sequence specific short and long chain length heteropolymers. More specifically, the method is directed to enzyme-mediated ligation of telechelic sequence specific oligomers to generate abiotic linked oligomers and concatenated synthetic oligomers. The invention also encompasses abiotic linked oligomers and abiotic... Agent: Klauber & Jackson

20070054296 - Methods for multiplexing recombinase polymerase amplification: This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes.... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20070054309 - Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease: Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro modulation of the cells with specific... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20070054268 - Methods of diagnosis and prognosis of ovarian cancer: The present invention provides novel genes and proteins for diagnosing ovarian cancer and/or a likelihood for survival, or recurrence of disease, wherein the expression of the genes and proteins is up-regulated or down-regulated or associated with the occurrence or recurrence of a specific scanner sub-type. The ovarian cancer-associated genes and... Agent: Cozen O'connor, P.c.

20070054302 - Methods of screening for risk of proliferative disease and methods for the treatment of proliferative disease: A method of screening a subject for a proliferative disease risk factor comprises detecting the presence or absence of upregulation of the CLN3 gene in the subject. The upregulation of the CLN3 gene in the subject indicates the subject is at increased risk of developing a proliferative disease. Methods of... Agent: Myers Bigel Sibley & Sajovec

20070054301 - Methods, compositions and kits for isothermal amplification of nucleic acids: Methods and compositions are described for isothermal nucleic acid amplification of a nucleic acid template strand by using an oligonucleotide primer that includes an AT-rich nucleotide sequence and a polymerase having strand displacement activity.... Agent: Gen Probe Incorporated

20070054273 - Microarray devices having controllable reaction volume: This invention relates generally to the field of microarray chips and uses thereof. In particular, the invention provides a microarray reaction device that can be used in assaying the interaction between various moieties, e.g., nucleic acids, immunoreactions involving proteins, interactions between a protein and a nucleic acid, a ligand-receptor interaction,... Agent: Morrison & Foerster LLP

20070054293 - Microfluidic chaotic mixing systems and methods: Microfluidic nucleic acid hybridization systems are described that include a first reaction chamber to hold an analyte solution comprising nucleic acids, and a first mixing channel in fluid communication with the chamber. The mixing channel includes a textured surface to mix the analyte solution. The systems may also include pump... Agent: Townsend And Townsend And Crew, LLP

20070054269 - Molecular cardiotoxicology modeling: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of... Agent: Cooley Godward LLP

20070054310 - Novel polypeptide, cdna encoding the same, and use thereof: Novel polypeptides produced by a human adult brain tissue, a cell line derived therefrom, a cell line derived from human bone marrow and a human umbilical cord venous endothelial cell line; a process for producing these polypeptides; cDNAs encoding the polypeptides; fragments hybridizable selectively with the cDNA sequences; replication or... Agent: Sughrue Mion, Pllc

20070054284 - Nucleic acid and corresponding protein entitled 184p1e2 useful in treatment and detection of cancer: A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 184P1E2 gene... Agent: Agensys C/o Morrison & Foerster LLP

20070054313 - Oligonucleotide mediated nucleic acid recombination: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.... Agent: Bingham, Mccutchen LLP

20070054279 - Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase: One aspect of the present invention relates to a double-stranded oligonucleotide comprising at least one ligand tethered to an altered or non-natural nucleobase. In certain embodiments, the non-natural nucleobase is difluorotolyl, nitropyrrolyl, or nitroimidazolyl. In certain embodiments, the ligand is a steroid or aromatic compound. In certain embodiments, only one... Agent: Foley Hoag, LLP

20070054278 - Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof: The present invention is based on the discovery of polymorphisms in enzyme genes and encoded enzyme protein variants. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and... Agent: Celera Genomics Attn: Wayne Montgomery, Vice Pres, Intel Property

20070054276 - Polynucleotide analysis and methods of using nanopores: Polynucleotide analysis systems and methods of nanopore analysis are provided.... Agent: Agilent Technologies, Inc. Intellectual Property Administration

20070054270 - Preloaded microfluidic devices: A microfluidic device comprising one, two or more microchannel structures (101a-h), each of which comprises a reaction microcavity (104a-h) intended for retaining a solid phase material in the form of a wet porous bed. Each of said one, two or more microchannel structures comprises the solid phase material in a... Agent: Fulbright & Jaworski, LLP

20070054267 - Primer and probe for detecting vibrio vulnificus and detection method using the same: To produce a high-performance specific gene amplification primer for detecting, quantifying, or identifying Vibrio vulnificus, having low risk of misidentification and practically sufficient amplification efficiency and amplification specificity. We have determined partial nucleotide sequences of gyrB, rpoD, and recA genes of Vibrio vulnificus and the closely related species, revealed their... Agent: Sughrue Mion, Pllc

20070054288 - Programmable molecular barcodes: The present disclosure concerns methods for producing and/or using molecular barcodes. In certain embodiments of the invention, the barcodes comprise polymer backbones that may contain one or more branch structures. Tags may be attached to the backbone and/or branch structures. The barcode may also comprise a probe that can bind... Agent: Lisa A. Haile, J.d., Ph. D. Dla Piper Rudnick Gray Cary Us LLP

20070054307 - Snail, a new marker for tumour invasion and target protein of new antitumoral compounds: The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumour cells. This invention presents: a new target protein, Snail, for the identification of new antitumoral compounds and a new diagnostic tumour marker, indicative of... Agent: Dann, Dorfman, Herrell & Skillman

20070054291 - System for detection of nucleic acids: System, including methods, apparatus, and kits, for detection of nucleic acids.... Agent: Kolisch Hartwell, P.c.

20070054320 - Cytokine zalpha11 ligand antibodies: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller... Agent: Zymogenetics, Inc. Intellectual Property Department

20070054317 - Electrochemical affinity biosensor system and methods: The present invention provides novel osmium-based electrochemical species for the detection of wide variety of analytes using immunological techniques. The present invention also provides diagnostic kits and test sensors supporting electrode structures that can be used with the osmium-based electrochemical species. The test sensor can be fabricated to support interdigitated... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20070054319 - Light-activated cation channel and uses thereof: The present invention provides compositions and methods for light-activated cation channel proteins and their uses within cell membranes and subcellular regions. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-activated cation channels to specific cells or defined cell populations. In particular the invention... Agent: Wilson Sonsini Goodrich & Rosati

20070054315 - Magnetic substance-biosubstance complex structure, peptide fragment capable of linking to magnetic substance and gene therefor, and process for producing the complex structure: A magnetic substance-biosubstance complex structure comprises a magnetic substance-containing carrier and a bio-substance immobilized on the carrier, the biosubstance being immobilized through a spacer comprising an amino acid sequence on a surface of the carrier.... Agent: Fitzpatrick Cella Harper & Scinto

20070054316 - Radical activated cleavage of biologics and microfluidic devices using the same: Disclosed is a cleavage method for biological sample characterization using hydroxyl radical activated cleavage in place of traditional enzymatic approaches. The hydroxyl radicals are generated from a semiconductor excited by an energy source. A microfluidic device for the two-dimensional separation of biological samples by hydroxyl radical activated cleavage is also... Agent: Day Pitney LLP

20070054318 - Soluble low-density lipoprotein receptor related protein binds directly to alzheimer's amyloid-beta peptide: A soluble derivative of low-density lipoprotein receptor related protein-1 (sLRP-1) binds directly to Alzheimer's amyloid-β peptide (Aβ). This binding may be used to detect Aβ or to separate Aβ from the rest of a subject's body. In Alzheimer's disease, it may be used to provide diagnostic results by detecting Aβ,... Agent: Nixon & Vanderhye, Pc

20070054324 - Cat1 transporters expressed in blood brain barrier cells: CAT1 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the CAT1 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in... Agent: Townsend And Townsend And Crew, LLP

20070054325 - Materials and methods for screening modulators of neural regeneration: The invention provides materials and methods used to identify modulators of neurogenesis and neuroregeneration, and use of said modulators in the treatment of neurodegenerative diseases and neurological injury.... Agent: Marshall, Gerstein & Borun LLP

20070054322 - Methods and kits for the detection of prion diseases: The present invention relates to a method for the diagnosis of a neurodegenerative disorder in a mammalian subject. The method of the invention comprises the steps of (a) providing a body fluid sample of said subject; (b) concentrating proteins comprised within said sample by a suitable means; (c) contacting the... Agent: Banner & Witcoff

20070054321 - Methods of diagnosing and treating inflammatory diseases using pac-1 (dusp2): The present invention relates generally to the diagnosis and treatment of inflammatory diseases such as rheumatoid arthritis and asthma in humans and other animals. The invention also relates to a method for identifying agonists and antagonists of the enzyme PAC-1 (DUSP2) that are useful in the therapeutic methods described herein.... Agent: Marshall, Gerstein & Borun LLP

20070054323 - Oct3 transporters expressed in blood brain barrier cells: OCT3 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the OCT3 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in... Agent: Townsend And Townsend And Crew, LLP

20070054327 - Cell observation apparatus: There is provided cell observation apparatus (10) comprising cell observation chamber (30) and optical observation means (70), the cell observation chamber (30) having, disposed thereinside, a pair of wells and a channel through which the wells communicate with each other so that cells of a cell suspension stocked in one... Agent: Bacon & Thomas, Pllc

20070054329 - Biomarker for ovarian and endometrial cancer: hepcidin: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status as well as endometrical cancer status in a patient. In particular, it has been found that hepcidin is a biomarker for both ovarian cancer and endometrial cancer and that a panel of biomarkers,... Agent: Edwards Angell Palmer & Dodge LLP

20070054330 - Determination of responders to chemotherapy: The present invention relates to a method of determining whether a biological sample comprising human lung cancer cells is sensitive to a combination of an epidermal growth factor receptor inhibitor and a chemotherapeutic agent by determining the overexpression of a phosphorylated AKT protein and/or a phosphorylated MAPK protein in the... Agent: Hoffmann-la Roche Inc. Patent Law Department

20070054328 - Methods: A method for identifying a compound for modulating the cellular activity or location of PTPL1, comprising the step of identifying a compound that modulates the interaction of PTPL1 with TAPP; or which modulates or mimics the interaction of TAPP with Ptdlns(3, 4)P2; or which modulates the cellular location of TAPP.... Agent: Rogalsky & Weyand, LLP

20070054332 - Syndecan 1 ectodomain inhibits cancer: The present invention provides for the treatment of cancers, e.g., carcinomas, using the ectodomain of syndecan 1, where the ectodomain lacks heparan sulfate residues. In addition, agents that bind the ectodomain of syndecan 1 also are useful as anti-cancer therapeutics.... Agent: Fulbright & Jaworski L.l.p.

20070054331 - System and method of evaluation of stochastic interactions of a soluble ligand with a target cell population for optimization of drug design and delivery: A computer system for recommending an optimal treatment protocol comprising a model of biological processes related to a disease. A treatment protocol generator generates a plurality of treatment protocols for treating a disease using drugs. A selector selects an optimal treatment protocol from said plurality of treatment protocols based on... Agent: Sughrue Mion, Pllc

20070054333 - Tumor suppressor designated ts10q23.3: A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel... Agent: Myriad Genetics Inc. Intellecutal Property Department

20070054336 - Compounds and methods for diagnosis and immunotherapy of tuberculosis: Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable... Agent: Townsend And Townsend And Crew, LLP

20070054334 - Method for diagnosing infections: Antigens are removed from the surface of an organism, such as a microorganism, without disrupting the organism and releasing internal antigens of the organism. The free surface antigens of the organism may be used to determine the presence of infection in an animal due to the organism by determining the... Agent: Howard Eisenberg, Esq.

20070054335 - Universal rapid test and method for detection of tuberculosis in multiple host species: A universal test apparatus for detecting tuberculosis (TB) in any of many different species of non-primate mammals is provided. The universal test apparatus includes a test site having a mycobacterial antigen cocktail comprising ESAT-6/CFP10 and 16 kDa/MPB83 polyfusion antigens, and a tracer having the ESAT-6/CFP10 polyfusion antigen and MPB83 antigen... Agent: Gordon & Jacobson, P.c.

20070054326 - Antibody-based protein array system: The invention of novel protein microarrays and protein microarray-based techniques to determine the presence and amounts of proteins of interest are described. These microarrays and methods of use can be used for the simultaneous detection of a multiplicity of antigens or antibodies in a high throughput assay based upon the... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20070054339 - Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor: Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070054340 - Method and antibodies for detecting nitrofuran: An antibody and immunogen for generating an antibody to nitrofuran and/or nitrofuran metabolite such as tissue or protein bound nitrofuran metabolites. Nitrofurans and and/or nitrofuran metabolites in a biological sample can be detected by contacting the sample with the antibodies to form a complex that can be detected. The antibodies... Agent: Charm Sciences, Inc.

20070054337 - Nanoparticle conjugates and method of production thereof: The present invention relates to a nanoparticle conjugate comprising a nanoparticle conjugated to a plurality of peptides of a substantially similar amino acid sequence, a peptide conjugated to the nanoparticle by means of a Cysteine (C) residue and the nanoparticle conjugate further comprising a ligand attached to the peptide and... Agent: Morrison & Foerster LLP

20070054338 - Single receptor assays for immunosuppressive drugs: A highly specific homogeneous assay method for an immunosuppressive drug using an immunophilin in a single receptor format is provided. In the simplest format, a single receptor is utilized analogous to a competitive immunoassay whereby an immunophilin is substituted for an antibody, and a competition results between a drug conjugate... Agent: Roche Diagnostics Operations Inc.

20070054341 - Immunoassay and reagents and kits for performing the same: A sandwich immunoassay is disclosed that provides simple to perform yet sensitive identification of analytes in samples. All assay constituents needed (except analyte to be detected) for one assay are dried. Upon reconstitution with sample, a 10 to 15 minute incubation gives a rapid and convenient detection assay capability. The... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.c.

20070054342 - Luciferase detection assay system: The invention relates to methods and kits for detecting enzyme activity using bioluminescence. In particular, it relates to a novel assay system with increased light yield for a sensitive and convenient detection of luciferase activity, such as luciferase reporter enzyme activity. Provided is a method of detecting luciferase activity in... Agent: Hoffmann & Baron, LLP

20070054343 - Use of thiol-reactive reagents for detecting enzyme activity: Disclosed are assays useful for detecting enzyme activity. The assays may utilize thiol-reactive reagents. The assays may include reacting a reacting mixture that contains an ATP analog (e.g., ATPβS or GTPβS) to form an ADP analog (e.g., ATPβS or GTPβS).... Agent: Foley & Lardner LLP

20070054345 - Expression quantification using mass spectrometry: In various aspects, the present teachings provide systems, methods, assays and kits for the absolute quantitation of protein expression. In various aspects, the present teachings provide methods of determining the concentration of one or more proteins of interest in one or more samples of interest. In various aspects, the present... Agent: Lahive & Cockfield, LLP

20070054346 - Method for measuring protease activity of transglutaminase and transglutaminase composition: The invention provides a method for measuring the protease activity of a transglutaminase-containing product comprising: mixing an aqueous solution (sample solution) of a transglutaminase-containing product and an aqueous solution of dimethylcasein in a prescribed ratio of transglutaminase activity to quantity of dimethylcasein, allowing the mixture to stand under prescribed conditions... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.c.

20070054344 - Novel fructosyl peptide oxidase and utilization thereof: The present invention is directed to a defructosylation enzyme originating from a plant, a method of defructosylating a fructosylated peptide or protein through use of the enzyme, and a method of measuring a fructosylated peptide or protein.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.c.

20070054348 - Methods of screening bifunctional molecules for modulated pharmacokinetic properties: Methods for screening bifunctional molecules of a drug of interest for modulated pharmacokinetic properties are provided. The subject methods include combining in a reaction mixture a metabolizer of the drug of interest, a reporter of activity of the metabolizer; and a bifunctional compound of the drug of interest. Signal from... Agent: Bozicevic, Field & Francis LLP

20070054347 - Oxidative stress measurement device and related methods: For measuring an oxidative stress component in a patient, an optical analyzer having a light source and a light detector is used for measuring an optical property of a medium and generating optical measurement data. A processor analyzes the optical measurement data and generates a value for one or more... Agent: Bereskin And Parr

20070054349 - Biochip: A biochip comprising a substrate defining a plurality of fluid holding areas, the fluid holding areas separated by fluid separating elements for preventing mixing of fluids held in the fluid holding areas until the application of pressure to one or more of the fluids.... Agent: Ostrager Chong Flaherty & Broitman Pc

20070054350 - System and method for rapidly identifying pathogens, bacteria and abnormal cells: The present invention achieves rapid identification of pathogens, bacteria, cancer cells and other abnormal human and animal cells. In one embodiment, the system of the present invention comprises a first subsystem that obtains and processes images of specimens of pathogens, bacteria, and other abnormal cells, and a second subsystem that... Agent: Law Offices Of Raymond A. Nuzzo, Llc

20070054351 - Green algae having a high astaxanthin content and method for producing the same: An encysted green alga is cultivated in a nutrient medium with a supply of carbon dioxide under irradiation with light at a photosynthetically active photon flux input of 25000 μmol-photon/m3/s or more, so that a green alga containing astaxanthin in an amount of 700 pg/cell or more, a dry product... Agent: Le-nhung Mcleland

20070054352 - Hydrolysed casein product comprising tripeptides ipp and/or vpp: Process for the preparation of a hydrolysed casein product comprising tripeptides VPP, IPP and/or LPP, wherein a substrate comprising casein or casein fragments is subjected to enzyme treatment wherein the enzyme is derived from Aspergillus, wherein the enzyme concentration is 2-10 wt. % based on casein and that the enzyme... Agent: Unilever Intellectual Property Group

20070054363 - 84p2a9: a prostate and testis specific protein highly expressed in prostate cancer: A novel gene (designated 84P2A9) and its encoded protein is described. While 84P2A9 exhibits prostate and testis specific expression in normal adult tissue, it is aberrantly expressed multiple cancers including prostate, testis, kidney, brain, bone, skin, ovarian, breast, pancreas, colon, lymphocytic and lung cancers. Consequently, 84P2A9 provides a diagnostic and/or... Agent: Agensys C/o Morrison & Foerster LLP

20070054355 - Cbl-b polypeptides, complexes and related methods: The application provides novel complexes of Cbl-b polypeptides and Cbl-b-associated proteins. The application also provides methods and compositions for treating Cbl-b-associated diseases such as viral disorders.... Agent: Fish & Neave Ip Group Ropes & Gray LLP

20070054360 - Compositions and methods for modulating immune responses: The present invention provides a newly identified B7 receptor, zB7R1 that functions as lymphocyte inhibitory receptor, which is a PD-1-like molecule and is expressed on T cells. The present invention also provides the discovery of zB7R1's ability to bind to CD155. Methods and compositions for modulating zB7R1-mediated negative signaling and... Agent: Zymogenetics, Inc. Intellectual Property Department

20070054361 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Genentech, Inc.

20070054354 - E.coli host cells with modified phos/psts periplasmic phosphate-binding proteins, and method of manufacturing recombinant fabs: The present invention provides an Ecoli host cell expressing a recombinant antibody characterized in that the Ecoli host cell has been genetically modified in order to change at least one physical property of one or more Ecoli proteins which in the wild type copurify with said recombinant antibody.... Agent: Woodcock Washburn LLP

20070054356 - Glycine-rich proteins, their coding genes and applications: This invention relates to Glycine-rich protein (Glyrichin), as well as its coding gene and application, especially relates to the application for antibacterial purpose. The Glyrichin of the present invention are at least one selected from the following protein families: proteins having amino acid residues in Sequence 1, 3-14 in the... Agent: Amin, Turocy & Calvin, LLP

20070054357 - Identification of useful bacteriophage: A method of identifying particular bacteriophage is provided.... Agent: Bell, Boyd & Lloyd Llc

20070054358 - Insertion sequence-free bacteria: A bacteria lacking genomic and non-genomic IS elements is provided. The bacteria may be more stable and useful for the production of amino acids, polypeptides, nucleic acids and other products.... Agent: Fulbright & Jaworski L.l.p.

20070054353 - Nuclear receptor transcriptional corepressor and uses thereof: The present invention provides a novel class of transcriptional corepressor polypeptides having an amino acid sequence which comprises at least one LXXLL nuclear receptor interacting NR box motif wherein L is leucine and X is any amino acid residue, and which are operably interactable with a nuclear receptor to actively... Agent: Keown & Associates

20070054364 - Polypeptide variants: The invention relates to the provision of oligomeric polypeptides (dimers, trimers etc) comprising the ligand binding domains of cytokines which are linked via flexible polypeptide linker molecules. The linker molecules optionally comprise protease sensitive sites to modulate the release of biologically active cytokines when administered to a human or animal... Agent: Crowell & Moring LLP Intellectual Property Group

20070054359 - Rational chemical modification of adiponectin variants: An adiponectin variant with at least a 3-fold increased solubility relative to residues 110-244 of human adiponectin, wherein the adiponectin variant has at least one covalently attached non-peptide moiety at at least one position selected from the group consisting of: A108, Y109, S146, D179, E220, R221, and L224, relative to... Agent: Xencor

20070054362 - Recombinant production of mixtures of antibodies: The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention... Agent: Trask Britt

20070054365 - Proteinase inhibitor, precursor thereof and genetic sequences encoding same: The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid molecule comprising a sequence of nucleotides which encodes or is complementary to a sequence which encodes a type II serine proteinase inhibitor (PI)... Agent: Scully Scott Murphy & Presser, Pc

20070054374 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070054375 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070054376 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070054377 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070054366 - Fvii or fviia variants: Variants of FVII or FVIIa comprising at least one amino acid modification in position 196, 237 or 341 relative to hFVII or hFVIIa. The variants exhibit an increased clotting activity, i.e. reduced clotting time, compared to rhFVIIa.... Agent: Maxygen, Inc. Intellectual Property Department

20070054378 - Elicitation of antibodies to self peptides in mice by immunization with dendritic cells: Antibodies are produced by inoculating a host animal with dendritic cells in combination with a self peptide of interest. In one embodiment, antibodies are produced by grafting tissue from one or more human immune organs into an immunodeficient, non-human, mammalian host such as, for example, a SCID mouse and then... Agent: Fish & Neave Ip Group Ropes & Gray LLP

20070054382 - Genes encoding carbon metabolism and energy-producing proteins: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.... Agent: Lahive & Cockfield, LLP

20070054383 - Genes encoding carbon metabolism and energy-producing proteins: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.... Agent: Lahive & Cockfield, LLP

20070054381 - Genes encoding genetic stability, gene expression and folding proteins: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.... Agent: Lahive & Cockfield, LLP

20070054380 - L-lysine-producing corynebacteria and process for the preparation of l-lysine: The invention relates to L-lysine-producing strains of corynebacteria with enhanced lysE gene (lysine export carrier gene), in which strains additional genes chosen from the group comprising the dapA gene (dihydrodipicolinate synthase gene), the lysC gene (aspartate kinase gene), the dapB gene (dihydrodipicolinate reductase gene) and the pyc gene, but especially... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20070054379 - Nucleotide sequences which encode the pfk gene: The present invention is directed to nucleotide sequences coding for phosphofructokinase which have been Corynebacterium glutamicum, and a process for the production of an L-amino acid comprising culturing a coryneform bacteria comprising an overexpressed pfk gene, wherein said pfk gene comprises a polynucleotide having a nucleotide sequence which is at... Agent: Pillsbury Winthrop Shaw Pittman, LLP

20070054385 - Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts: Two acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica). Specifically, the genes encoding phophatidylcholine-diacylglycerol acyltransferase (PDAT) and diacylglycerol acyltransferase (DGAT2) have been isolated from Y. lipolytica. These genes encode enzymes that participate in the terminal... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070054384 - Method for the cultivation of microorganisms of the genus thraustochytriales by using an optimized low salt medium: The invention relates to an optimized method for cultivating microorganisms of the genus Thraustochytriales, according to which the microorganisms are cultivated in a low salt medium without adding sodium salts and chloride salts, the total salt content being less than 3.5 g/L (corresponding to less than 10 percent of sea... Agent: Hammer & Hanf, Pc

20070054386 - Mutant poly (3-hydroxyalkanoic acid) synthases: A mutant poly(3-hydroxyalkanoic acid) synthase comprising an amino acid sequence of (a) or (b) below. (a) A mutant amino acid sequence derived from SEQ ID No. 1, wherein at least one amino acid selected from the group consisting of glutamic acid at position 130, serine at position 325, serine at... Agent: Birch Stewart Kolasch & Birch

20070054387 - Novel rumen bacteria variants and process for preparing succinic acid employing the same: The present invention relates to novel rumen bacterial mutants resulted from the disruption of a lactate dehydrogenase gene (ldhA) and a pyruvate formate-lyase gene (pfl) (which are involved in the production of lactic acid, formic acid and acetic acid) from rumen bacteria; a novel bacterial mutant (Mannheimia sp. LPK7) having... Agent: Intellectual Property / Technology Law

20070054388 - Method for immobilising microorganisms, related material, and use thereof: The present invention relates to a method for immobilising microorganisms (particularly yeasts or bacteria), a related material, and the use thereof in fermentation or bioconversion. Specifically, the present invention relates to the immobilisation of microorganisms in optionally dehydrated polymeric spheres consisting of two or more layers. The technical problem is... Agent: Wenderoth, Lind & Ponack, L.l.p.

20070054389 - Expression of heterologous functional oxygen-sensitive proteins in filamentous cyanobacteria: Functional oxygen-sensitive proteins are expressed in a heterologous diazotrophic cyanobacteria cell in the presence of ambient extracellular oxygen.... Agent: Bozicevic, Field & Francis LLP

20070054390 - Method of weak partitioning chromatography: This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or... Agent: Wilmerhale/wyeth

20070054391 - Dna detection device and manufacturing method thereof: A DNA (Deoxyribo Nucleic Acid) detection device and a manufacturing method thereof detects DNA by an electrical method without a separate process for detection by using semiconductor microfabrication techniques. The DNA detection device includes a pair of chambers formed on a semiconductor substrate for accommodating a detection sample, a channel... Agent: Cantor Colburn, LLP

20070054392 - Method for characterizing a surface, and device therefor: The present invention relates to a method of characterizing a surface and to a device for implementing this method. In particular, this method makes it possible to measure, qualitatively and/or quantitatively, interactions that may be physical, chemical, biochemical or biological.... Agent: Oliff & Berridge, Plc

20070054393 - Dispensing device: The invention relates to a dispensing device for dispensing particle suspensions (12), especially cell suspensions, comprising a reservoir (10) for receiving the particle suspension (12). A suspending agent (26) is provided in the reservoir (10) that influences the particle suspension (12). The suspending agent (26) serves to preserve homogenous particle... Agent: Griffin & Szipl, Pc

20070054395 - Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications: First generation adenoviral vectors and associated recombinant adenovirus-based HIV vaccines which show enhanced stability and growth properties and greater cellular-mediated immunity are described within this specification. These adenoviral vectors are utilized to generate and produce through cell culture various adenoviral-based HIV-1 vaccines which contain HIV-1 gag, HIV-1 pol and/or HIV-1... Agent: Merck And Co., Inc

20070054394 - Recombinant protein production in a human cell: Methods and compositions for the production of recombinant proteins in a human cell line. The methods and compositions are particularly useful for generating stable expression of human recombinant proteins of interest that are modified post-translationally, for example, by glycosylation. Such proteins may have advantageous properties in comparison with their counterparts... Agent: Trask Britt

20070054397 - Adult cardiac uncommitted progenitor cells: The invention provides for adult cardiac uncommitted progenitor cells (UPCs), methods of making such cells, and methods of using such cells in the treatment, repair and/or regeneration of damaged cardiac tissue.... Agent: Fish & Richardson P.c.

20070054396 - Cell line and methods for determining viral titer: The present invention relates to cells, methods, compositions and kits for determining the concentration of virus in a stock, i.e., determining the titer of a viral stock.... Agent: Invitrogen C/o Intellevates Castellano Malm Ferrario & Buck Pllc

20070054398 - Human salivary gland-origin stem cell: A novel human stem cell which can be differentiated to cells constituting a plurality of human organs including human liver is disclosed. The human stem cell according to the present invention is originated from human salivary gland, which is CD49f-positive, and which can be differentiated to (1) a nestin-positive and... Agent: Birch Stewart Kolasch & Birch

20070054399 - Method for differentiating mesenchymal stem cell into neural cell and pharmaceutical composition containing the neural cell for neurodegenerative disease: The present invention provides a method of differentiating and proliferating a mesenchymal stem cell into the neural cell by culturing in a medium comprising an epidermal growth factor and a hepatocyte growth factor after confluent culture of the mesenchymal stem cell. The present invention provides more effective method of differentiating... Agent: Sughrue Mion, Pllc

20070054400 - Modified low molecular weight glutenin gene in plants: The present invention relates to transgenic plants, such as wheat or maize, comprising plant cells having SEQ.ID.NO 1 and seeds derived from those plants. It also relates to the use of said seed for the preparation of a flour which in turn is used for the preparation of food and/or... Agent: Howrey LLP

20070054401 - Composition for intracellular transport of biological particles or macromolecules: The invention relates to a composition comprising a macromolecule or particle having one or several hydrophobic domains on the surface thereof whereby at least one transducer peptide is adsorbed thereon. Said composition can be used to introduce the macromolecule or particle into living cells.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.c.

20070048725 - Machine perfusion of tissue grafts for transplantation: Methods and apparatuses for exsanguination or replacement of blood in a tissue are presented. These methods and apparatuses may be used to preserve and prepare an organ or other tissue for transplantation while increasing the likelihood of a successful procedure. Improved methods are also provided for the splitting of organs... Agent: Blank Rome LLP

20070048726 - Methods and compositions for the control of molecular-based cell death during preservation of cells, tissues or organs in a gel-like state: Gel-based medium compositions and a method of use thereof in normothermic, hypothermic or cryopreservative storage and transport of cell samples are described. These gel-based compositions preferably include an agent that inhibits apoptosis, together with a gelling agent. Such gel-based medium compositions protect various cell samples, such as animal or plant... Agent: Brown & Michaels, PC 400 M & T Bank Building

20070048727 - Biliary barrier: Systems and methods are disclosed for microscale pharmacokinetics. Various organs and their interactions with drug compounds can be simulated in vitro by use of microscale compartments that can be interconnected by microscale channels. Cells or cellular materials associated with the organs can be cultured in such compartments to allow interactions... Agent: Knobbe Martens Olson & Bear LLP

20070048732 - Chemosensitivity tester: A novel method for testing the chemosensitivity of a substance in a bioartificial tissue slice system is more effective than conventional cell culture systems and function by treating the bioartificial tissue slice system's samples with at least one compound and observing the effect on the bioartificial tissue slices resident therein,... Agent: Greenberg Traurig LLP

20070048730 - Global alignment of sequence data: To determine optimal alignment of two molecules, an alignment space of two strings representing element sequences of the molecules is conceived as a grid of cells, where each cell represents alignments between substrings of the two strings. The cells are tested against conditions that are framed, in the context of... Agent: Anthony England

20070048731 - High throughput use-dependent assay based on stimulation of cells on a silicon surface: The invention pertains generally to the field of drug discovery science. More specifically, the invention refers to a drug screening assay and device that is used to test the effect of specific chemical compounds as use dependent ion channel blockers. The invention includes a unique method for stimulating cells with... Agent: Fish & Richardson P.C.

20070048728 - Hydroxylases and modulators thereof: A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070048729 - Method of creating a collection of biological specimens, and collection of specimens: The invention relates to a method of creating a collection of isolated biological specimens, wherein each isolated biological specimen is preserved within a defined length of time following isolation of the specimen from its natural environment and is subsequently stored, and wherein the defined length of time between isolation and... Agent: Raymond J Lillie Carella Byrne Bain Gilfillan Cehhi Stewart & Olste

20070048733 - Novel enhanced processes for drug testing and screening using human tissue: A novel method for testing human tissue in a testing system is more effective than conventional cell culture systems and functions by treating the human tissue slice system's samples with at least one compound and observing the effect on the human tissue slices resident therein, or cells, tissue samples or... Agent: Greenberg Traurig LLP

20070048734 - Novel enhanced processes for drug testing including neoplasmic tissue slices and products thereby: A novel method for testing neoplasmic tissue in a testing system is more effective than conventional cell culture systems and functions by treating the neoplasmic tissue slice system's samples with at least one compound and observing the effect on the neoplasmic tissue slices resident therein, or cells, tissue samples or... Agent: Greenberg Traurig LLP

20070048736 - Hepatitis: An isolated nucleic acid containing a mutant hepatitis B virus genome and related methods.... Agent: Fish & Richardson PC

20070048735 - Methods for rapid detection and identification of biogents in epidemiological and forensic investigations: The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.... Agent: Medlen & Carroll LLP

20070048769 - Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance: The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to... Agent: Kilpatrick Stockton LLP - M0351

20070048755 - Assay for determining the sex of primates: The present invention relates to methods for identifying the sex of a primate by providing a biological sample collected from the primate and contacting the biological sample with one or more probes that hybridize to a target SRY nucleic acid molecule at a particular location within a consensus SRY nucleotide... Agent: Nixon Peabody LLP - Patent Group

20070048737 - Calcium phosphate ceramics and particles for in vivo and in vitro transfection: The invention relates to a method of modifying the surface of calcium phosphate ceramics and powders. The inventive method involves maturation in a culture medium, thereby causing epitaxial carbonated apatite growth at the surface of the aforementioned ceramics and powders. The invention also relates to the use of said modified... Agent: Foley And Lardner LLP Suite 500

20070048780 - Circovirus sequences associated with piglet weight loss disease (pwd): The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors are provided. Methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a... Agent: Bingham, Mccutchen LLP

20070048774 - Continuous in-vitro evolution: Provided is a method for the mutation, synthesis and selection of a protein of interest, by first incubating a replicable RNA molecule encoding the protein with ribonucleoside triphosphate precursors of RNA and an RNA-directed RNA polymerase, such that the RNA-directed RNA polymerase replicates the RNA molecule but introduces mutations thereby... Agent: Frommer Lawrence & Haug

20070048742 - Detection method for chromosome abnormality and microarray chip: The present invention relates to a method of detecting a chromosome abnormality and a microarray chip for detecting a chromosome abnormality. More specifically, the present invention is directed to a method of detection for chromosome abnormality in order to easily diagnosing the health condition and disease of the subject by... Agent: Christie, Parker & Hale, LLP

20070048783 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the... Agent: Nixon Peabody LLP - Patent Group

20070048773 - Detection of polyphosphate using fluorescently labeled polyphosphate acceptor substrates: Provided herein are methods and compositions for fluorogenic detection of a polyphosphate released from a nucleoside polyphosphate by the enzymatic action of a nucleic acid polymerase. The methods and compositions are based on the transfer of a free polyphosphate (or polyphosphate labeled with a fluorescence dye) to a polyphosphate acceptor... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070048759 - Detection of target molecules with labeled nucleic acid detection molecules: The invention is directed to a detection molecule for detection of a target molecule. The detection molecule includes a probe specific to the target molecule. One or more multimer nucleic acid molecules are connected to the probe, whereby the multimer is also coupled to at least one detectable label. The... Agent: Wilson Sonsini Goodrich & Rosati

20070048760 - Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules: A device for quantitatively determining an analyte is provided to conspicuously improve the performance of the quantitative determination. This device is equipped with a flow channel, an analyte detecting unit for capturing and detecting the analyte, and a quantitative measurement unit for quantitatively determining the analyte, wherein a signal generated... Agent: Armstrong, Kratz, Quintos, Hanson & Brooks, LLP

20070048754 - Epidermal growth factor receptor mutations: Mutations of the epidermal growth factor receptor (EGFr), of phosphatidylinositol 3′-kinase (“Pl3K”), and of B-Raf are described. Methods of treating tumors containing mutated EGFr with human monoclonal antibodies against EGFr are described. Methods and kits for ascertaining the presence of one or more mutant EGFr, mutant Pl3K, and/or mutant B-Raf... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070048775 - Evolution of whole cells and organisms by recursive sequence recombination: The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.... Agent: Maxygen, Inc. Intellectual Property Department

20070048740 - Full-length cdna: Novel full-length cDNAs are provided. 1,995 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information... Agent: Foley And Lardner Suite 500

20070048758 - Improved primer-based amplification methods: The present invention provides methods for amplifying a target nucleic acid with greater efficiency and accuracy by using one or more flap primers.... Agent: Townsend And Townsend And Crew, LLP

20070048764 - Indicator polynucleotide controls: Methods of selecting indicator polynucleotide controls for use, for example, in determining amounts of indicated polynucleotides in a sample are described. Devices that include indicator polynucleotide controls and data representations relevant to them are also described. A storage medium comprising data obtained from a study using a nucleotide array that... Agent: Perkins Coie LLP

20070048781 - Mammalian cytokines; related reagents and methods: Purified genes encoding cytokines from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this molecule are provided. Methods of using said reagents and diagnostic kits are also provided.... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070048772 - Mammalian iap gene family, primers, probes and detection methods: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes.... Agent: Philip Swain, Phd C/o Gowling Lafleur Henderson

20070048767 - Marker for a psychosis or a mood disorder: An association of a genetic marker with psychosis, a mood disorder, or a combination thereof is provided. Polymorphisms in the GRIN2B gene or alteration in the levels of GRIN2B gene products can be used to diagnose or identify a susceptibility to psychosis, a mood disorder, or a combination thereof. In... Agent: Suzannah K. Sundby

20070048752 - Mass tags for quantitative analyses: This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070048779 - Method for detecting target plant genus: The method for detecting species in a target plant genus, particularly an allergenic plant genus such as the genus Fagopyrum, can make it possible to detect with high sensitivity, for example, about 1 ppm of the plant(s) in cases where the plant(s) is contained in a food ingredient or food... Agent: Hoffmann & Baron, LLP

20070048739 - Method for identifying biological species: The present invention provides a method for identifying species and subspecies in a biological sample through the selective amplification of segments of nucleic acid that code a target region of the cytoplasmatic beta-actin protein, which is present in all the organisms concerned. The method comprises DNA extraction from the sample;... Agent: Gottlieb Rackman & Reisman PC

20070048749 - Method for survival prediction in gastric cancer patients after surgical operation using gene expression profiles and application thereof: Disclosed is a method for survival prediction in gastric cancer patents after surgical operation, which uses a survival prediction model determined by known statistical method and gene expression microarray profiles. The survival prediction model is established by selecting special genes expressing significantly differential from pairs of cancerous and noncancerous tissue... Agent: Birch Stewart Kolasch & Birch

20070048751 - Method of diagnosing type ii diabetes mellitus using multilocus marker, polynucleotide including marker associated with type ii diabetes mellitus, and microarray and diagnostic kit including the polynucleotide: Provided are a polynucleotide including a marker associated with type II diabetes mellitus and a method of diagnosing type II diabetes mellitus in an individual, which includes determining a nucleotide of a polymorphic site of at least one polynucleotide of Table 1 in the specification.... Agent: Cantor Colburn, LLP

20070048777 - Method of nucleic acid analysis by optical detection using disk: There is provided a method or structure of carrying out optical measurement for the change of the state of the reactive sample solution at two or more measurement points of the channel simultaneously and continuously in a flow system reaction in which the reactive proceeds according to the elapsed time... Agent: Knobbe Martens Olson & Bear LLP

20070048743 - Methods and compositions for assessing candidate acgh probe nucleic acids: Methods for evaluating surface-bound polynucleotides, e.g., candidate aCGH probe nucleic acids, are provided. Specifically, the methods involve contacting an array of surface-bound polynucleotides with a validation nucleic acid composition and assessing binding of the surface-bound polynucleotides. The methods may be used to screen for surface bound polynucleotides that have desirable... Agent: Agilent Technologies Inc.

20070048738 - Methods and compositions for diagnosis, staging and prognosis of prostate cancer: The present invention provides, inter alia, novel methods and compositions for the diagnosis, staging and prognosis of prostate cancer, based on DNA methylation and/or modulation of gene expression, including transcriptional silencing. Preferred diagnostic and/or prognostic nucleic acid and protein markers include at least one of: the differentially (relative to benign... Agent: Davis Wright Tremaine, LLP

20070048741 - Methods and kits for sense rna synthesis: Methods and kits are provided for performing sense RNA synthesis. The sense RNA molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays.... Agent: Datascope Investment Corp.

20070048747 - Methods for assaying analytes: Described herein are methods for assaying analytes.... Agent: Corning Incorporated

20070048782 - Methods for assessing and treating leukemia: Methods for treating leukemia patients include analyzing gene expression profiles of a patient to determine whether the patient is likely to respond to treatment with farnesyl transferase inhibitor (FTI) and, optionally, other therapeutics. The methods are also useful for monitoring patient therapy and for selecting a course of therapy. Genes... Agent: Philip S. Johnson Johnson & Johnson

20070048757 - Methods for characterizing cells using amplified micro rnas: The present teachings provide methods, compositions, and kits for reverse transcribing and amplifying small nucleic acids such as micro RNAs. In some embodiments, the present teachings provide methods of forming micro RNA signatures from single cells, including stem cells. In some embodiments, the present teachings provide methods for determining the... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20070048768 - Methods for screening for gene specific hybridization polymorphisms (gshps) and their use in genetic mapping and marker development: A method for identification of gene specific hybridization polymorphisms (GSHPs) and their use is presented. The method involves the steps of a) global screening for hybridization polymorphisms using microarray; b) enzyme mediated genome complexity reduction; c) enzyme mediated differential signal amplification and noise reduction; d) data extraction and GSHP identification;... Agent: Larry W. Stults, Ph.d. Syngenta Biotechnology, Inc.

20070048756 - Methods for whole genome association studies: Methods for determining the genotype of more than 400,000 Single Nucleotide Polymorphisms (SNPs) in samples of genomic DNA are provided. A collection of SNPs that may be interrogated by the methods is disclosed in SEQ ID NO: 1-1,074,930. Each sequence is the sequence of a human SNP allele and the... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070048746 - Multiplex data collection and analysis in bioanalyte detection: Method and device to collect multiplex data simultaneously in analyte detection and analyze the data by experimentally trained software (machine-learning) is disclosed. Various ways (magnetic particles and microcoils) are disclosed to collect multiple reporter (tag) signals. Multiplex detection can increase the biomolecule analysis efficiency by using small sample size and... Agent: Morrison & Foerster LLP

20070048748 - Mutant polymerases for sequencing and genotyping: The invention relates to the discovery of novel mutant DNA polymerases that possess altered kinetics for incorporating phosphate-labeled nucleotides during polymerization. The invention further relates to the use of these mutant DNA polymerases in sequencing and genotyping methods.... Agent: Townsend And Townsend And Crew, LLP

20070048771 - Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the... Agent: Millennium Pharmaceuticals, Inc.

20070048784 - Novel human hydrolase family members and uses thereof: The invention provides isolated nucleic acids molecules, designated 26443 and 46873 nucleic acid molecules, which encode novel human hydrolase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26443 and 46873 nucleic acid molecules, host cells into which the expression vectors have been introduced, and... Agent: Millennium Pharmaceuticals, Inc.

20070048763 - Polymorphism in the macrophage migration inhibitory factor (mif) gene as marker for prostate cancer: The present invention relates to the risk assessment, detection, diagnosis, or prognosis of prostate cancer. More specifically, this invention relates to the detection of certain polymorphism in the promoter region of the MIF gene to determine the risk, detect, diagnose, or prognosticate prostate cancer. Applicants have discovered that the presence... Agent: Blank Rome LLP

20070048750 - Rapid efficacy assessment method for lung cancer therapy: The present invention discloses a method for rapid assessment of lung cancer therapy efficacy in a few days instead of weeks by conventional imaging methods. This method can also be used to detect relapse of the cancer and to improve the current TNM cancer staging method for more accurate prognosis.... Agent: Pai Patent & Trademark Law Firm

20070048770 - Reagents and methods for processing biological samples: Methods and processing reagents for improving washing and aging a biological sample in an assay are disclosed. The processing reagents comprise an aqueous base reagent and a low vapor pressure composition in sufficient amount to raise the boiling point of the base reagent. The methods comprise applying the base reagent... Agent: Vysis, Inc Patent Department

20070048762 - Real-time monitoring of nucleic acid target-identifying signals: This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other... Agent: Eric P. Mirabez

20070048744 - Single molecule sequencing of captured nucleic acids: The invention provides methods and devices for detecting, enumerating or identifying target nucleic acid molecules using immobilized capture probes and single molecule sequencing techniques.... Agent: Proskauer Rose LLP

20070048753 - Sodium channel protein type iii alpha-subunit splice variant: The present invention is directed to a splice variant of a human sodium channel alpha subunit and methods and compositions for making and using the same.... Agent: Marshall, Gerstein & Borun LLP

20070048761 - System and method for authenticating multiple components associated with a particular product: A method for authenticating a product where the product is composed of a plurality of components is described. The method for authenticating the product comprises providing a liquid compound, e.g. paint, that comprises at least one invisible market, e.g. nucleic acid, in which the compound is associated with a first... Agent: Virtual Legal, P.C. Michael A. Kerr

20070048745 - Systems and methods for partitioned nanopore analysis of polymers: Devices, systems, and methods for nanopore analysis of polymers are provided. One exemplary device, among others, includes a substrate having a plurality of partitioned nanopores configured to receive a polymer sample. In addition, the device includes a plurality of sets of resonant tunneling electrodes adjacent the partitioned nanopore. At least... Agent: Agilent Technologies Inc.

20070048776 - Translation enhancer-element dependent vector systems: A translation enhancer-driven positive feedback vector system is disclosed which is designed to facilitate identification of a Translational Enhancer Element (TEE) and to provide a means for overexpression of gene products. The system exploits both transcriptional and translational approaches to control the expression levels of genes and/or gene products. Methods... Agent: Dla Piper US LLP

20070048765 - Use of genetic information for identity authentication: This invention incorporates genetic information about an individual for use in verifying said individual's identity in transactions where improper identity, identity theft or other use of false identifying information creates financial, personal or other risks. The invention utilizes secure methods wherein an individual's genetic identity is stored by an authenticating... Agent: Fredric D. Abramson Alphagenics, Inc.

20070048778 - Uses of human zven antagonists: The present invention provides methods of using Zven1 and Zven2 polypeptides to increase chemokine production. The present invention also provides methods of using antagonists to Zven1 and Zven2 to treat inflammation in the intestine.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048800 - Affinity matrices with enhanced visibility for molecular pull-down and immunoprecipitation applications: An affinity matrix for use in affinity based molecular pull down and immunoprecipitation procedures. The affinity matrix comprises a polymeric support, a dye attached to a fraction of the polymeric support to enable optical detection of the polymeric support, and an affinity ligand other than the dye attached to a... Agent: Senniger Powers

20070048785 - Anti-il-13 antibodies and complexes: Anti-IL-13 antibodies, crystals of anti-IL-13 antibodies, IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13 polypeptide/anti-IL-13 antibody complexes, IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, crystals of IL-13Rα1 polypeptide/IL-13 polypeptide/anti-IL-13 antibody complexes, and related methods and software systems are disclosed.... Agent: Fish & Richardson P.C.

20070048788 - Apparatus, system, and method of detecting an analyte utilizing pyroelectric technology: A system for the measurement of a target analyte is provided including a detection apparatus and a reading apparatus. The detection apparatus, or “carrier”, includes a pyroelectric transducer (“pyroelectric film”) and one or more reagent concentrations (“reagent deposit”) deposited on the film. The reagent deposits are adapted to react with,... Agent: Bradley D. Goldizen

20070048789 - Apparatus, system, and method of detecting an analyte utilizing pyroelectric technology: A system for the measurement of a target analyte is provided including a detection apparatus and a reading apparatus. The detection apparatus, or “carrier”, includes a pyroelectric transducer (“pyroelectric film”) and one or more reagent concentrations (“reagent deposit”) deposited on the film. The reagent deposits are adapted to react with,... Agent: Bradley D. Goldizen

20070048796 - Biosensor: It is an object of the present invention to provide a biosensor with an improved recovery yield of a test substance interacting with a physiologically active substance. The present invention provides a biosensor having a flow channel formed on a substrate, which is composed of a detection surface for detecting... Agent: Sughrue Mion, PLLC

20070048797 - Composite organic inorganic nanoclusters as carriers and identifiers of tester molecules: Metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. The nanoclusters are generally referred to as COINs (composite organic inorganic nanoparticles) and are capable of acting as sensitive reporters for analyte detection. Embodiments of the invention provide methods for detecting and... Agent: Intel/blakely

20070048793 - Compositions and methods for biocatalytic engineering: Provided herein are compositions and methods for metabolic pathway engineering. The methods involve combining two or more cells expressing potential pathway proteins extracellularly in the presence of reactants. Also provided are libraries of cells expressing a plurality of pathway components and/or a plurality of variants of a given pathway component... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070048794 - Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use: The present invention provides processes for determining the molecular weight of glatiramer acetate and other copolymers. The present invention further provides a plurality of molecular weight markers for determining the molecular weight of glatiramer acetate and other copolymers which display linear relationships between molar ellipticity and molecular weight, and between... Agent: Cooper & Dunham, LLP

20070048791 - Crystal structures and models for fc receptors and uses thereof in the design or identification of fc receptor modulator compounds: The invention relates to the determination of the three-dimensional structures of Fc receptor proteins, particularly wild-type FcγRIIa, by X-ray crystallography and the use of the structure in identifying and modifying agents for modulating the biological activity of Fc receptors. Also disclosed is a novel dimeric structure for FcγRIIa and novel... Agent: Sheridan Ross PC

20070048799 - Cytokine receptor zcytor19: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048790 - Device for measuring nanometer level pattern-dependent binding reactions: The present invention is directed to a device comprising (a) a substrate having a surface and (b) an ordered array of posts over the surface, wherein the posts are capable of binding a protein or small molecule ligand, and wherein the pitch between adjacent posts is less than about 100... Agent: Wilmerhale/columbia University

20070048798 - Il-21 production in prokaryotic hosts: The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Using the expression vectors,... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048795 - Immunoaffinity separation and analysis compositions and methods: The present invention provides compositions and methods for immunoaffinity separation of targets from mixtures for enrichment, identification, quantification, and analysis. In particular, disclosed are avian IgY antibodies coupled to solid supports and their methods of use. Further disclosed are systems and methods for fractionating or enrichment a mixture of biological... Agent: Xiangming Fang

20070048787 - Multi-analyte affinity column: A multi-analyte column is disclosed. The column may contain at least one unit of resin having ochratoxin specific affinity and, for each unit of resin having ochratoxin specific affinity, the column further contains about 0.95 to 1.05 units of resin containing antibody having specificity for zearalenone, about 1.9 to 2.1... Agent: Edwards & Angell, LLP

20070048792 - Preparing biological samples for analysis: Methods and devices for preparing a biological sample for analysis are described. The biological sample from an organism has at least macromolecule having a primary structure that naturally degrades after the sample is removed from the organism. The method includes causing the biological sample to adopt a shape to permit... Agent: Fish & Richardson P.C.

20070048786 - Systems and methods for fractionation of protein mixtures: Methods for proteomics analysis, including fractionation or separation of one or more biomolecules that exist in a mixture, for example, using aqueous multi-phase partitioning, which results in isolation of one or more preselected biomolecules, followed by further proteomics analysis.... Agent: Pearne & Gordon LLP

20070048801 - Cxcr3 is a gliadin receptor: Gliadin is identified as a physiological receptor for CXCR3. Assays for determining modulators of CXCR3 signaling are provided. Fragments of gliadin which function as inhibitors of CXCR3 signaling can be determined. Methods for treating diseases relating to gluten and/or autoimmunity by targeting CXCR3 are provided. Such diseases include celiac disease,... Agent: Connolly Bove Lodge Hutz, LLP (for Alba Therapeutics Cases

20070048803 - Immune profiling of lymph nodes associated with cancer: Cancers are phenotyped by analysis of the presence of immune cells, particularly T cells and dendritic cells, present in regional lymph nodes. When non-sentinel regional lymph nodes of a cancer patient are compared to normal lymph nodes, it is found that increased number of dendritic cells and decreased numbers of... Agent: Bozicevic, Field & Francis LLP

20070048802 - Method and kit for detection of autoimmune chronic urticaria: Disclosed is a rapid, non-invasive and highly specific and sensitive diagnostic assay for the identification of individuals with autoimmune chronic urticaria, which makes use of CD203c, and in some embodiments, additional proteins, as a marker for the disease. Test kits for diagnosis of an individual suspected of having autoimmune chronic... Agent: Sheridan Ross PC

20070048804 - Methods of detecting cytokine receptor zcytor19 ligand: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048805 - Methods of using zven antibodies: The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048806 - Microarrays on mirrored substrates for performing proteomic analyses: Provided are peptidomimetic protein-binding arrays, their manufacture, use, and application. The protein-binding array elements of the invention include a peptidomimetic segment linked to a solid support via a stable anchor. The invention contemplates peptidomimetic array element library synthesis, distribution, and spotting of array elements onto solid planar substrates, labeling of... Agent: Novartis Vaccines And Diagnostics Inc.

20070048810 - Atp-binding cassette protein responsible for cytotoxin resistance: This invention provides for a novel ATP-binding cassette protein which is responsible for cytotoxin resistance. The invention also provides for methods of expressing the protein and assays for identification of inhibitors of the protein.... Agent: Townsend And Townsend And Crew, LLP

20070048809 - Detection and treatment of prostate cancer: An antigen is shown to be associated with prostate cancer, and is useful for new methods and compositions for diagnosing or treating prostate cancer. This is particularly useful for individuals with prostate cancer who test negative for Prostate Specific Antigen. Additionally, this is useful for distinguishing between benign prostate disease... Agent: Seed Intellectual Property Law Group PLLC

20070048808 - Hepatocellular carcinoma screening: A method for identifying individuals at risk for developing hepatocellular carcinoma is described. The method detects differential patterns of gene expression that are caused by the presence of hepatitis B virus x antigen.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070048811 - Tumor suppressor designated ts10q23.3: A specific region of chromosome 10 (10q23.3) has been implicated by series of studies to contain a tumor suppressor gene involved in gliomas, as well as a number of other human cancers. One gene within this region was identified, and the corresponding coding region of the gene represents a novel... Agent: Myriad Genetics Inc. Intellecutal Property Department

20070048807 - Diagnostic test kits with improved detection accuracy: A diagnostic test kit that provides an integrated system for accurately detecting a test analyte over a broad range of possible concentrations is provided. One feature of the integrated system is that it is capable of indicating whether an analyte is within the “hook effect” region. Based on this indication,... Agent: Dority & Manning, P.A.

20070048812 - Cell-based luminogenic and nonluminogenic proteasome assays: A method to detect proteasome activity in permeabilized cells, and optionally in a multiplex assay to detect presence or amount of at least one molecule for a different enzyme-mediated reaction, is provided.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20070048813 - Agent for assaying analyte of patient by enzyme: This invention concerns an enzymatic reagent for measuring the analyte concentration in a patient by determination of oxidation rate of a reduced coenzyme. Said reagent is stabilized by the coenzyme reduction system which makes the reduced coenzyme in the reagent regenerate continuously throughout a long storage. This coenzyme reduction system... Agent: Birch Stewart Kolasch & Birch

20070048814 - Novel purified dihydrodipicolinate synthase polypeptides and structures thereof: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070048815 - Enzyme detection technique: A diagnostic test kit for detecting the presence or absence of an enzyme (e.g., leukocyte esterase) within a test sample is provided. The test kit comprises a substrate that is capable of being cleaved in the presence of the enzyme to release a nucleophilic aromatic compound. The kit also comprises... Agent: Dority & Manning, P.A.

20070048816 - Detection of proteases secreted from pathogenic microorganisms: A diagnostic test kit for detecting the presence or absence of a protease (e.g., aminopeptidase) within a test sample is provided. The test kit comprises a substrate that is capable of being cleaved in the presence of the protease to release a compound. The kit also comprises a lateral flow... Agent: Dority & Manning, P.A.

20070048817 - Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives: The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors comprising said polynucleotides, micro-organisms transformed with said polynucleotides, uses of said polynucleotides and said polypeptides, as well as methods for the synthesis of diketopiperazine derivatives, including cyclodipeptides... Agent: Gary M. Nath Nath & Associates PLLC

20070048819 - Canine influenza vaccines: The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza.... Agent: Judy Jarecki-black, Ph.d,j.d

20070048821 - Canine influenza vaccines: The present invention encompasses influenza vaccines, in particular canine influenza vaccines. The vaccine may be a recombinant poxvirus vaccine or an inactivated vaccine. The invention also encompasses recombinant poxvirus vectors encoding and expressing influenza antigens, epitopes or immunogens which can be used to protect animals, in particular dogs, against influenza.... Agent: Judy Jarecki-black,ph.d,j.d

20070048823 - Compositions and methods for producing apolipoprotein gene products in lactic acid bacteria: The present disclosure relates to compositions and methods for producing recombinant apolipoproteins in lactic acid bacteria.... Agent: Dechert LLP

20070048825 - Compositions and methods for the diagnosis and treatment of tumor: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.... Agent: Genentech, Inc.

20070048831 - Cytokine receptor zcytor17 multimers: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048832 - Cytokine receptor zcytor17 multimers: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048833 - Cytokine receptor zcytor17 multimers: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048834 - Cytokine receptor zcytor17 multimers: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048835 - Cytokine receptor zcytor17 multimers: Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048836 - Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form... Agent: Klauber & Jackson

20070048822 - Erbb4 receptor-specific neuregulin related ligands and uses therefor: The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain,... Agent: Genentech, Inc.

20070048829 - Growth factor homolog zvegf4: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048830 - Growth factor homolog zvegf4: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 70% identical to residues 52-179 of SEQ ID NO:2 or residues 258-370 of SEQ ID NO:2. Multimers of the... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048818 - Human secreted proteins: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing... Agent: Human Genome Sciences Inc Intellectual Property Dept.

20070048824 - Interleukin-17 receptor homologue: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor14.”... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048827 - Mammalian transforming growth factor beta-9: Novel mammalian Ztgfβ-9 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048828 - Materials and methods for preparing dimeric growth factors: Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048820 - Methods for assaying inhibition of hiv-1 envelope glycoprotein-mediated membrane fusion: This invention provides: agents determined to be capable of specifically inhibiting the fusion of a macrophage-tropic primary isolate of HIV-1 to a CD4+ cell, but not a T cell-tropic isolate of HIV-1 to a CD4+ cell; and agents determined to be capable of specifically inhibiting the fusion of a T... Agent: Cooper & Dunham, LLP

20070048839 - Novel amylolytic enzyme extracted from bacillus sp. a 7-7 (dsm 12368) and washing and cleaning agents containing this novel amylolytic enzyme: The invention relates to a novel amylolytic enzyme extracted from the micro-organism Bacillus sp. A 7-7 (DSM 12368), to sufficiently similar proteins having an amylolytic function, to methods for the production thereof and to diverse fields of application for these proteins. In addition, they can be further developed beyond the... Agent: Connolly Bove Lodge & Hutz LLP

20070048838 - Peptide-forming enzyme gene, peptide-forming enzyme, and peptide producing method: The present invention provides a method for producing dipeptide using inexpensively acquirable starting materials by an industrially advantageous and simple pathway. Dipeptide is produced from L-amino acid ester and L-amino acid using a culture of microbes having the ability to produce a dipeptide from an L-amino acid ester and an... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070048837 - Site specific protein modification: Processes for conjugating proteins with polyethylene glycol are disclosed. The disclosed processes provide modified proteins having little or no decrease in their activity and include the steps of deleting at least one amino acid residue on the protein, replacing the at least one amino acid residue with an amino acid... Agent: Immunex Corporation Law Department

20070048826 - Soluble zcytor14, anti-zcytor14 antibodies and binding partners and methods of using in inflammation: The present invention relates to blocking, inhibiting, reduceing, antagonizing or neutralizing the activity of IL-17F, IL-17A, or both IL-17A and IL-17F polypeptide molecules. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. ZcytoR14 is a common receptor for IL-17A and IL-17F. The present invention includes... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048840 - Human zven polynucleotides: The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1 - 3p14.3, is expressed in testicular tissue and peripheral blood... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048841 - Interferon-like protein zcyto21: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048845 - Cytokine zalpha11 ligand fusion proteins: Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048843 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048844 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048842 - Il-21 production in prokaryotic hosts: The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary structure for translation in E. coli. Using the expression vectors,... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048846 - Antibodies to cytokine receptor zcytor19: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048847 - Methods of producing antibodies to cytokine receptor: Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention... Agent: Zymogenetics, Inc. Intellectual Property Department

20070048848 - Method, apparatus and system for biodiesel production from algae: The present disclosure concerns methods, apparatus, compositions and systems relating to closed bioreactors for algal culture and harvesting. In certain embodiments, the system may comprise bags with various layers, including a thermal barrier layer, that may be used to contain the algal culture and/or to thermally regulate the temperature of... Agent: Faegre & Benson LLP Patent Docketing

20070048849 - Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism: A process is provided for the bioconversion of a carbon substrate to 1,3-propanediol by a single organism utilizing microorganisms containing the genes encoding for an active glycerol or diol dehydratase enzyme by contacting these organisms with a carbon substrate under the appropriate fermentation conditions.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20070048851 - Method for sustained microbial production of hydrogen gas in a bioreactor using klebsiella oxytoca: The present invention provides a method of hydrogen production from microorganisms, wherein a bioreactor provides an environment conducive to the production of hydrogen from Klebsiella oxytoca and restrictive to the production of methane from methanogens. Klebsiella oxytoca metabolizes organic material at elevated temperatures and pH levels that are detrimental to... Agent: Eckert Seamans Cherin & Mellott

20070048850 - System for sustained microbial production of hydrogen gas in a bioreactor using klebsiella oxytoca: The present invention provides a system of hydrogen production from microorganisms, wherein a bioreactor provides an environment conducive to the production of hydrogen from Klebsiella oxytoca metabolism and restrictive to the production of methane from methanogens. Klebsiella oxytoca metabolizes organic material at elevated temperatures and pH levels that are detrimental... Agent: Eckert Seamans Cherin & Mellott

20070048852 - Directed selective solid-phase culturing of stable microbial mixed populations for the continuous preparation of defined enzyme and metabolite mixtures: The present invention provides a method for directed selective solid-phase culturing of stable microbial mixed populations for the continuous preparation of defined enzyme and metabolite mixtures, enzyme and metabolite materials obtained by such method and suitable devices therefore.... Agent: Needle & Rosenberg, P.C.

20070048853 - Carnitine palmitoyltransferase ii crystals: The present invention provides crystals of carnitine palmitoyltransferase (CPT) and co-crystals of CPT with an inhibitor compounds that allow screening for novel inhibitors of CPT-2 by determining the structure of co-crystals based on the coordinates of the crystals disclosed herein.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20070048854 - Los locus from c. jejuni: This invention provides prokaryotic glycosyltransferases, including a bifunctional sialyltransferase that has both an α2,3- and an α2,8-activity. A β1,4-GalNAc transferase and a β1,3-galactosyltransferase are also provided by the invention, as are other glycosyltransferases and enzymes involved in synthesis of lipooligosaccharide (LOS). The glycosyltransferases can be obtained from, for example, Campylobacter... Agent: Townsend And Townsend And Crew, LLP

20070048855 - Variants and chemically-modified variants of phenylalanine ammonia-lyase: The present invention pertains to the use of the protein phenylalanine ammonia-lyase, as well as the biologically-active derivatives of the said protein for preventing or treating diseases associated with a phenylalanine imbalance in a human or animal body. More particularly, the present invention relates to the therapeutic use of the... Agent: Fenwick & West LLP

20070048856 - Gas purification apparatus and process using biofiltration and enzymatic reactions: The invention provides a gas purification apparatus for purifying effluent gas by treating VOCs and the CO2 gas, comprising a biofiltration chamber containing micro-organisms for degrading the VOCs and producing a partially cleansed gas containing CO2 gas by-product; and an enzymatic chamber comprising an enzyme capable of catalyzing the hydration... Agent: Ware Fressola Van Der Sluys & Adolphson, LLP

20070048857 - Automatic macroinjection apparatus and cell trapping plate: A cell trapping plate traps a cell by applying a negative pressure suction through a trapping hole provided therein. A capillary needle is stuck into the trapped cell to inject an injectant. The cell trapping plate includes trapping holes arranged at irregular intervals in directions of two coordinate axes in... Agent: Staas & Halsey LLP

20070048858 - Low adsorption surface: A device comprising an analytical sample substrate having at least one region that comprises a plurality of sample-support-structures. Each of the sample-support-structures have at least one dimension of about 1 millimeter or less. A sum of areas of contact surfaces of the sample-support-structures is substantially less than a total area... Agent: Hitt Gaines, PC Lucent Technologies Inc.

20070048859 - Closed system bioreactor apparatus: The present disclosure concerns an apparatus and system comprising closed bioreactors for aquaculture and harvesting. In certain embodiments, the system may comprise bags with various layers, including a thermal barrier layer, that may be used to contain the aquaculture and/or to thermally regulate the temperature of the aquaculture. The system... Agent: Faegre & Benson LLP Patent Docketing

20070048860 - Carcinoembryonic antigen (cea) peptides: The present invention relates to novel modified CEA agonist (or antagonist) peptides, polypeptides and proteins containing a modified epitope therein, nucleic acids coding therefor, vectors comprising said nucleic acids, mixtures and compositions of the aforementioned agents, and their advantageous use in generating CEA-specific immune responses and/or in the treatment of... Agent: Office Of Technology Transfer National Institutes Of Health

20070048861 - Compositions and methods for generating an immune response: The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding immunogens derived from any pathogen, including fungi, bacteria and viruses. The present invention,... Agent: Fish & Richardson PC

20070048862 - Vectors based on recombinant defective viral genomes and their use in the formulation of vaccines: The vectors comprise a recombinant defective viral genome expressing at least one antigen suitable for the induction of systemic and secretory immune responses or an antibody conferring protection against an infectious agent. The defective viral genome comprises the genome of a parental virus having the viral replicase recognition signals located... Agent: Wyeth/finnegan Henderson, LLP

20070048863 - Computerized factorial experimental design and control of reaction sites and arrays thereof: Computer-facilitated design of large-scale, multi-factorial cell culture experiments and the like, and control of reaction sites and/or arrays of reaction sites to perform such experiments using automated devices. In certain cases, the invention is directed to controlling a plurality of cell culture experiments, e.g., using an automated cell culture device.... Agent: Wolf Greenfield & Sacks, PC

20070048864 - Isolation of inner cell mass for the establishment of human embryonic stem cell (hesc) lines: A method for isolating an inner cell mass comprising the steps of immobilizing a blastocyst stage embryo having a zona pellucida, trophectoderm, and inner cell mass, creating an aperture in the blastocyst stage embryo by laser ablation, and removing the inner cell mass from the blastocyst stage embryo through the... Agent: Vinson & Elkins, L.L.P.

20070048865 - Method for acceleration of stem cell differentiation: The present invention relates to methods for accelerating the differentiation of embryonic stem cells by introducing nucleic acid encoding the Tal1/Scl transcription factor into the cells, and culturing the transduced cells in a differentiation medium.... Agent: Heller Ehrman LLP