Chemistry: molecular biology and microbiology inventions 03/07

20070072166 - Semen preservation: The present invention provides a method for determining the suitability of a sample of mammalian semen for cooling and/or cryopreservation or storage, which comprises: (a) providing said sample of semen; (b) determining the level of a hydrophobic stimulator of 11β-HSD activity in said sample; and (c) assessing, from the level... Agent: Nixon & Vanderhye, PC

20070072172 - Liver specific chimeric regulatory sequence and use thereof: The present invention relates to a chimeric regulatory sequence with liver cell specificity. The chimeric regulatory sequence includes a proximal regulatory sequence and a distal enhancer 5 flanking region of human α-fetoprotein (AFP) gene. The chimeric regulatory sequence is useful in purified specific lineages, such as liver cells, from other... Agent: Bacon & Thomas, PLLC

20070072170 - Methods of determination of responsiveness to erythropoietin treatment: Methods for determining the responsiveness of a patient to recombinant human erythropoietin therapy are disclosed. In one approach, the method includes obtaining a volume-Hgb factor (VHf) defined as a product function of MCV and Hgb from a patient's blood sample; comparing VHf to a predetermined criterion; and reporting indication of... Agent: Beckman Coulter, Inc.

20070072168 - Microplate sample tracking system: The invention provides sample tracking systems and methods. A sample tracking system can comprise a plate having a plurality of sample wells and an apparatus for illuminating each individual sample well, wherein the manner with which the sample well is illuminated can track the loading of the sample components to... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070072169 - Process and apparatus for measuring binding events on a microarray of electrodes: There is disclosed a process and apparatus for reading electrical current of electrodes on a microarray of electrodes. Those electrodes having binding events are detected by a difference in electrical current flow. Enzymes on targets catalyze the conversion of substrate to product, which is detectable by electrochemical reduction at each... Agent: Combimatrix Corporation

20070072171 - Solid surface for biomolecule delivery and high-throughput assay: The present invention is related to a method for introducing biomolecules, such as nucleic acids, into cells by culturing cells on a solid surface which is coated with a transfection reagents and biomolecules.... Agent: Knobbe Martens Olson & Bear LLP

20070072167 - Tissue binding composition: The invention relates to a tissue binding composition. The inventive composition is characterised in that it comprises: between 40 g/l and 80 g/l trehalose, preferably approximately 60 g/l; between 40% and 80% (v/v) ethanol, preferably approximately 70% (v/v): between 0% and 5% (v/v) acetic acid, preferably approximately 1% (v/v); and... Agent: Foley And Lardner LLP Suite 500

20070072177 - Binding molecules capable of neutralizing rabies virus and uses thereof: The invention provides binding molecules that specifically bind to rabies virus and are capable of neutralizing the virus. The invention further provides nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The binding molecules can be used in... Agent: Trask Britt

20070072174 - Bioreporter for detection of microbes: A recombinant phage system has been developed for the rapid detection of bacteria, particularly fecal coliform indicator bacteria. The systems of the invention link phage infection events to quorum sensing signal molecule biosynthesis and bioluminescent bioreporter induction, facilitating the detection of pathogens that may be present in low numbers. The... Agent: Ruden, Mcclosky, Smith, Schuster & Russell, P.A.

20070072176 - Novel peptide compositions and their use in particular in the preparation of pharmaceutical compositions active against the hepatitis c virus: The invention relates to peptide compositions for use in the preparation of pharmaceutical compositions against hepatitis C virus, as well as corresponding methods.... Agent: Clark & Elbing LLP

20070072175 - Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof: This invention relates to a nucleotide array containing polynucleotide probes complementary to, or fragments of, Cynomolgus monkey genes, and the use of such a nucleotide array to characterize the biological effects, including the actions, targets, and toxicities, of therapeutic agents in primates, e.g., a human, a Cynomolgus monkey, or a... Agent: Sterne, Kessler, Goldstein & Fox, P.l.l.c.

20070072173 - Utilization of nucleotide probes in elisa procedure for the quantitative determination of baculovirus titer: To maximize the yield of protein from a baculovirus system, optimal infection of the host cell culture must be achieved; in order to obtain such optimal infection, the titer of the virus inoculation must be known. The present invention is the development of a simple, rapid, and universally applicable titration... Agent: Dr. Mai Nguyen Vista Biologicals Corporation

20070072225 - Antibodies with simultaneous subsite specificities to protein and lipid epitopes: Antibodies and method of making antibodies, either monoclonal or polyclonal wherein said antibodies have dual or multi-specific binding capacity to more than one type of antigenic epitope. The antibodies have simultaneous or independent recognition subsites to each of the epitopes. Antigenic epitopes include lipids, peptides, proteins, amino acid sequences, sugars... Agent: Caroline Nash Nash & Titus, LLC

20070072189 - Artificial mutation controls for diagnostic testing: Disclosed are artificial compositions that can be used as positive controls in a genetic testing assay, such as a diagnostic assay for a particular genetic disease. Such controls can be used to confirm the presence or absence of a particular mutation. Also provided are methods of generating such compositions, and... Agent: Klarquist Sparkman, LLP

20070072211 - Asymmetric pcr coupled with post-pcr characterization for the identification of nucleic acids: The present invention provides methods, compositions, and kits for quantification and identification of target nucleic acid sequences, either in pure solutions or from mixtures of various nucleic acids. In other aspects, the invention provides compositions and methods for HCV genotyping.... Agent: Roche Molecular Systems Inc Patent Law Department

20070072195 - Bio-commemorative article incorporating amplified genetic material: A combination of amplified genetic material from an individual or other organism with an inanimate article of manufacture to produce a bio-commemorative article is disclosed. The amplified genetic material is preferably produced from a polymerase chain reaction process. The amplified genetic material is coated onto the inanimate article of manufacture,... Agent: Rossi, Kimms & Mcdowell LLP.

20070072185 - Carbohydrate-binding modules of a new family: The present invention relates to non-catalytic carbohydrate-binding modules (CBM) belonging to a new family of CBM's. A CBM of the invention was found attached to a glycosyl hydrolase family 61 (GH61) polypeptide and was shown to have little homology with known CBM's indicating that it is the first known member... Agent: Novozymes North America, Inc.

20070072181 - Combination therapy for treating alphavirus infection and liver fibrosis: The present invention provides methods for treating alphavirus infections; methods of treating hepatitis C virus (HCV) infections; methods of treating West Nile virus infection; methods of reducing liver fibrosis; methods of increasing liver function in an individual suffering from liver fibrosis; methods of reducing the incidence of complications associated with... Agent: Bozicevic, Field & Francis LLP

20070072204 - Compositions and methods for cancer diagnosis and treatment: The application relates to methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the mir17-92 cluster. The application further relates to screening methods to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070072223 - Compositions and methods for purifying nucleic acids: Described herein are compositions and methods for enriching a nucleic acid sample for target sequence(s). The compositions comprise an oligonucleotide attached to a solid support, directly or indirectly, wherein the oligonucleotide does not serve as a primer for a polymerase enzyme.... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070072230 - Compositions, kits, and methods relating to the human fez1 gene, a novel tumor suppressor gene: The invention relates to isolated polynucleotides homologous with a portion of one strand of the human tumor suppressor gene, FEZ1, and to the tumor suppressor protein encoded thereby, Fez1. The polynucleotides are useful, for example, as probes, primers, portions of expression vectors, and the like. The invention also includes diagnostic,... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070072199 - Covalent methods for immobilization of thiolated biomolecules on siliceous and metallic surfaces: The present invention is directed to methods for immobilizing molecules on siliceous and metallic surfaces. Molecules are immobilized on siliceous or metallic surfaces by stable covalent linkages that are capable of withstanding prolonged use and elevated temperatures. Further, the methods of the present invention describe less-complicated chemistries for the immobilization... Agent: Wilmerhale/columbia University

20070072219 - Detection method of homologous sequences differing by one base on a microarray: The present invention is related to a detection method and kit of homologous sequences differing by one base on a microarray.... Agent: Knobbe Martens Olson & Bear LLP

20070072214 - Detection of truncation mutations by mass spectrometry: This invention relates to the detection and analysis by mass spec of nascent proteins, and in particular truncated proteins, translated within cellular or cell-free translation systems. N-terminal and C-terminal epitopes introduced into these nascent proteins permit rapid and efficient isolation, as well as a mass difference.... Agent: Medlen & Carroll, LLP

20070072224 - Diagnosis and treatment of tumor-suppressor associated disorders: Methods are provided for detecting a cell proliferative disorder associated with TSLC1 by contacting a proliferating cell of a subject suspected of having the disorder with a reagent that detects TSLC1 and detecting the level of TSLC1 in the proliferating cell. TSLC1 is a single gene whose expression is reduced... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP

20070072228 - Ercc2 polymorphisms: This invention relates to diagnostic methods based upon a polymorphism in individuals indicative of an increased risk of breast carcinoma. More specifically, this invention relates to a method for diagnosis of an increased risk of breast carcinoma by screening for the presence of genetic polymorphisms in individuals, specifically in the... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20070072222 - Fabp4 as biomarker for toxic effect: The present invention relates to FABP4 as a marker for determining at least one toxic effect of a compound of interest and methods for determining same.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20070072196 - Fluorescent nucleotide analogs and uses therefor: Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others.... Agent: Pacific Biosciences Of California, Inc.

20070072227 - Gamma secretase notch biomarkers: The present invention relates to biomarker indicators, including polypeptides, polynucleotides and small molecules, that measure γ-secretase mediated Notch processing. These indicators have utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The reagents and methods of the invention can be utilized... Agent: Louis J. Wille Bristol-myers Squibb Company

20070072194 - Global transcription machinery engineering: The invention relates to global transcription machinery engineering to produce altered cells having improved phenotypes.... Agent: Wolf Greenfield & Sacks, PC

20070072232 - Identification of genetic components of drug response: The present invention is concerned generally with the field of identifying an appropriate treatment regimen for a disease based upon genotype in mammals, particularly in humans. It is further concerned with the genetic basis of inter-patient variation in response to therapy, including drug therapy. Specifically, this invention describes the identification... Agent: Nuvelo, Inc

20070072191 - Infectious pestivirus pseudo-particles containing functional erns, e1, e2 envelope proteins: The invention relates to the generation and the use of pestivirus pseudo-particles containing native functional E1, E2 envelope glycoproteins assembled onto retroviral core particles. These particles are highly infectious and constitute a valid model of pestivirus virion.... Agent: Stites & Harbison PLLC

20070072193 - Ligand arrays having controlled feature size, and methods of making and using the same: Methods and compositions for producing a solid support having a ligand immobilized on a surface thereof, e.g. a ligand array, are provided. Aspects of the methods include: providing a solid support having a bounded feature location on a surface thereof, where the bounded feature location includes a region of the... Agent: Agilent Technologies Inc.

20070072213 - Method and apparatus for implementing non-destructive quality control of substrates and printed biological microarrays, and for implementing quality control and visualizing gel-based microarrays prepared by dispensing gel-forming composition on solid surf: A method and apparatus are provided for implementing non-destructive quality control of substrates and printed biological microarrays. A method and apparatus are provided for implementing quality control of gel-based microarrays prepared by dispensing a gel-forming composition on a solid substrate. The method utilizes the difference between the wettability properties of... Agent: Joan Pennington

20070072200 - Method for determining co-receptor selectivity of human immunodeficiency virus-1: Newly discovered structural characteristic of the gp120 V3 loop have resulted in a “rule” or algorithm, that is used in a method for determining whether a subject is infected with HIV-1 virus that expresses selectivity for CXCR4 or CCR5 chemokine receptors. A positively charged surface patch defined by V3 loop... Agent: Mckenna Long & Aldridge LLP

20070072216 - Method for diagnosis of glioma: distinguishging between progressive and de novo types: The present invention relates to a method for identifying the type of glioblastoma multiforme in mammals, preferably human subjects. More particularly, it relates to a kit for characterizing progressive glioma in mammals, preferably human subjects. More particularly, it relates to a kit for distinguishing primary and secondary glioblastoma multiforme (GBM)... Agent: Brinks Hofer Gilson & Lione

20070072229 - Method for isolation, amplification and quantitation of ribonucleic acid: A cellular RNA isolation method comprising treating at least one nucleated cell with a composition comprising mild detergents such as non-ionic detergent(s), buffer(s), chelator(s), reducing agent(s), salt(s), and RNase inhibitor(s) to result in a cytoplasmic lysate and intact nucleus, then separating the cytoplasmic lysate containing RNA from the nucleus, and... Agent: Wood, Herron & Evans, LLP

20070072201 - Method for producing improved nucleic acid oligomer functional homogeneity and functional characteristic information and results and oligomer application results: An approach and methods are provided for obtaining improved information and results concerning the functional homogeneity and functional characteristics of a chemically synthesized or biologically synthesized nucleic acid oligomer of any type, and for obtaining improved information and results concerning the functional homogeneity and functional characteristics of the oligomer under... Agent: Wesley B. Ames

20070072186 - Methods and agents for screening for compounds capable of modulating her2 expression: The invention relates to the fields of screening assays and compounds and methods for altering protein expression and levels of protein. In particular, the invention includes assays to screen for agents capable of modulating expression of Her2 and agents capable of modulating Her2 expression.... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20070072233 - Methods and systems for facilitating the diagnosis and treatment of schizophrenia: A method of diagnosing, assessing susceptibility, and/or treating schizophrenia involving the observation of regulator of G-protein signaling 4 (RGS4) levels in a subject. Embodiments of the present invention include increasing RGS4 expression levels in the cortex, either by chemical means or by genetic complementation (e.g. gene therapy).... Agent: Reed Smith LLP

20070072182 - Methods for amplification of nucleic acid sequences using staggered ligation: Methods and kits are provided for producing sense RNA molecules. The sense RNA molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20070072188 - Methods for detection of mycobacterium tuberculosis: The present invention provides an oligonucleotide primer pair having SEQ ID NO: 3 and SEQ ID NO: 4 for amplification of Early Secretory Antigenic Target (esat)-6-gene of Mycobacterium species. The invention also provides a method for detecting M .tuberculosis in a sample based on the amplification of esat-6 gene, comprising... Agent: Birch Stewart Kolasch & Birch

20070072203 - Methods for drug discovery, disease treatment, and diagnosis using metabolomics: The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.... Agent: Lahive & Cockfield, LLP

20070072209 - Methods of treatment and diagnosis of kaposi's sarcoma (ks) and ks related diseases: Aspects of the present invention use gene expression profiling, and gene silencing methods to identify and provide a plurality of ‘validated’ KSHV-induced cellular gene sequences and pathways useful as targets for modulation of KSHV-mediated effects on cellular proliferation and phenotype (e.g., cancer) associated with latent and lytic phases of the... Agent: Davis Wright Tremaine, LLP

20070072221 - Methods to screen peptide display libraries using minicell display: A minicell display method has been developed which has significant advantages for screening peptide libraries for candidates that can bind and effectively modulate a particular biological process. The method, based on the small, anucleate minicell, has increased versatility in generating unique sequences to screen as well as increasing the size... Agent: Cooley Godward Kronish LLP Attn: Patent Group

20070072197 - Microtags for detection and identification of materials: A customized microtag identifier has a custom synthesized polynucleic acid having a known sequence of bases, a recovery compound, and a protective coat; effective to identify said custom synthesized polynucleic acid,... Agent: Naval Surface Warfare Center, Dahlgren Division Office Of Counsel, Code Xdc1

20070072226 - Mining protein interaction networks: One embodiment is a method including creating a protein interaction network including a plurality of protein IDs and a plurality of interactions between protein IDs, determining confidences of interactions of the protein interaction network, identifying a sub-network of the protein interaction network, and determining relevance of proteins of the sub-network... Agent: Krieg Devault LLP

20070072198 - Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes: The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.... Agent: Joseph C. Zucchero

20070072180 - Mutations in nod2 are associated with fibrostenosing disease in patients with crohn's disease: The present invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease characterized by fibrostenosing disease by determining the presence or absence in an individual of a fibrostenosis-predisposing allele linked to a NOD2/CARD15 locus, where the presence of the fibrostenosis-predisposing allele is diagnostic of... Agent: Davis Wright Tremaine LLP

20070072205 - Nanomaterial error correction: The present invention makes use of the discovery that proofreading and error-correction techniques common in biological systems may be adapted to material science. Enzymes and aptamers are adapted to proofread and correct defects in nanoparticle structures.... Agent: Evan Law Group LLC

20070072220 - Non-fouling polymeric surface modification and signal amplification method for biomolecular detection: An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a polymer layer comprising brush molecules formed on the linking layer; and (d) optionally but preferably, a first... Agent: Myers Bigel Sibley & Sajovec

20070072178 - Novel genetic markers for leukemias: The present invention is related to methods for detecting leukemia cells by determining the expression profile of a group of markers. In particular, the type or subtype of leukemia cells in a sample is determined. Further, uses of the group of markers is discloses and compositions comprising these markers.... Agent: Quine Intellectual Property Law Group, P.C.

20070072187 - Novel methods and apparatus for cell based microarray assays: The present invention relates methods for screening of cellular responses comprising: (a) providing a solid porous support having first and second surfaces and at least one area with a plurality of through-going channels (b) providing cellular components on said first and/or second surface of said solid porous support, wherein said... Agent: Amster, Rothstein & Ebenstein LLP

20070072192 - Novel polypeptides encoded by essential bacterial genes: The present invention relates to polypeptide targets for pathogenic bacteria. The invention also provides biochemical and biophysical characteristics of those polypeptides.... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20070072208 - Nucleic acid analysis by random mixtures of non-overlapping fragments: The invention provides methods and kits for ordering sequence information derived from one or more target polynucleotides. In one aspect, one or more tiers or levels of fragmentation and aliquoting are generated, after which sequence information is obtained from fragments in a final level or tier. Each fragment in such... Agent: Stephen C. Macevicz C/o Chief Financial Officer

20070072215 - Nucleic acid-based logic circuits: This invention relates to nucleic acid-based logic gates. The invention further relates to circuits comprising nucleic acid-based logic gates and methods of performing operations with the gates and circuits provided herein.... Agent: Buchanan, Ingersoll & Rooney LLP

20070072207 - Production of vaccines: Means and methods are provided for the production of mammalian viruses comprising: infecting a culture of immortalized human cells with the virus, incubating the culture infected with virus to propagate the virus under conditions that permit growth of the virus, and to form a virus-containing medium, and removing the virus-containing... Agent: Trask Britt

20070072179 - Solid-phase assisted spectroscopic and spectrometric analysis of complex biopolymer mixtures: The present invention relates to a method and kit for analyzing complex mixtures of biopolymers from one or more samples.... Agent: Needle & Rosenberg, P.C.

20070072206 - Strong pcr primers and primer cocktails: The invention disclosed relates to a PCR primer pair for amplication of chaperonin-60 (cpn60) targets having high G+C content and to a PCR primer “cocktail” to improve the representation of diverse sequences in chaperonin-60 based PCR product libraries derived from complex templates. In previous cpn60-based and 16S rDNA-based studies of... Agent: Ade & Company Inc.

20070072184 - Susceptibility gene for alzheimer's disease: The invention relates to genetic screens for susceptibility to Alzheimer's disease. In particular, the invention provides genetic screens based on genotyping of the p21E2c31 polymorphism and/or the p21E3+20 C/T polymorphism in the p21cip 1 gene.... Agent: Synnestvedt & Lechner, LLP

20070072190 - System and method for universal identification of biological humans: A system and method for uniquely identifying each human being and generate a Universal Identification Number (UIN) to aid tracking. UIN database comprises of public, health, and confidential information. The number issued for display on UIN Identity Card and used for accessing data on-line protects privacy of the individual by... Agent: Dr. Abhinav Aggarwal

20070072183 - Topoisomerase hybrids and methods of use: The present invention provides hybrid topoisomerases, methods for assaying topoisomerase activity, methods for identifying compounds that modulate topoisomerase activity, and methods for identifying antibacterial agents.... Agent: Astrazeneca R&d Boston

20070072231 - Tumor suppressor gene: A full-length cDNA encoding novel proteins involved in the control of cell proliferation (human Gros1-L and S) was successfully isolated from the human testis cDNA libraries. A full-length cDNA encoding the mouse homologues of the human Gros1 (mouse Gros1-L and S) was also isolated. The colony forming activity of cells... Agent: Fish & Richardson PC

20070072218 - Tumor suppressor killin: The present invention relates to a new tumor suppressor, designated Killin. Also described are diagnostic and therapeutic uses of the Killin protein and the killin gene, alone or in combination with traditional cancer therapies.... Agent: Fulbright & Jaworski L.L.P.

20070072210 - Use of brca1-associated protein to treat and screen for dna damage and to identify therapeutics that promote a dna damage response: The present invention relates to the use of a BAAT1 protein to screen for potential therapeutics that promote a DNA damage response or treat breast cancer. The present invention also relates to a method of treating DNA damage or breast cancer in a subject by administering a compound that increases... Agent: Nixon Peabody LLP - Patent Group

20070072202 - Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors: The present invention provides novel materials and screening methods for identifying agonists and antagonists of cell receptors. Methods are disclosed for identifying agonists and antagonists using chimeric receptors comprising the extracellular ligand-binding domain of a first receptor fused with the transmembrane and intracellular domains of a second receptor containing an... Agent: Schering-plough Corporation Patent Department (k-6-1, 1990)

20070072212 - Use of markers including nucleotide sequence based codes to monitor methods of detection and identification of genetic material: The use of artificially-generated nucleic acid coded markers to monitor nucleic acid amplification and sequencing reactions designed to detect or analyze biological samples. The markers generally include, along with a unique sequence preferably including coded section designed to represent one or more factors of interest, primer annealing sequences so that... Agent: Kirby Eades Gale Baker

20070072217 - Xaf genes and polypeptides: methods and reagents for modulating apoptosis: The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.... Agent: Philip Swain, Phd C/o Gowling Lafleur Henderson

20070072241 - Diagnostic methods for age related macular degeneration: Diagnostic methods for identifying a test subject who has or is at risk of developing age-related macular degeneration (AMD) or an analogous disease associated with oxidation of DHA-containing lipids are provided. In one aspect, the methods comprise: assaying for the presence of elevated levels of 2-(ω-carboxyethyl) pyrrole (CEP) adducts in... Agent: Calfee Halter & Griswold, LLP

20070072242 - Immunoassay method and kit to leucomalachite green and malachite green: The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as, antibodies raised against such immunogens and capable of binding with leucomalachite green and malachite green.... Agent: Woodcock Washburn LLP

20070072240 - Method for producing an in vitro expression library: The present invention relates to an antibody expression library derived from a patient which has been immunochallenged with one or more foreign antigens associated with a particular disease or foreign agent, wherein said patients have been immunochallenged with the foreign antigens at a time point such that they still contain... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070072237 - Method of assessing rheumatoid arthritis by measuring rheumatoid factor and interleukin-6: The present invention relates to a method aiding in the assessment of rheumatoid arthritis. The method especially is used in assessing the absence or presence of rheumatoid arthritis in vitro. It can be best practiced by analyzing biochemical markers, comprising measuring in a sample the concentration of RF and interleukin-6... Agent: Roche Diagnostics Operations Inc.

20070072236 - Novel type ii na/pi cotransporters and type ii na/pi cotransporter expression regulatory factors: The present invention provides novel type IIc Na/Pi cotransporters. These cotransporters are important Pi transporters that are highly expressed during the growth period from the weaning stage to the adult stage. Furthermore, the present invention provides FGF23 and mutants thereof as factors that regulate the expression of type II Na/Pi... Agent: Fish & Richardson PC

20070072239 - Pharmaceutical compositions and methods of using secreted frizzled related protein: Methods and pharmaceutical compositions of use in regulation of mammalian bone-forming activities of SFRPs (secreted frizzled-related proteins) are disclosed. SFRPs are secreted receptors for Wnts, which are important polypeptide growth factors that are known to regulate fundamental biological processes such as tissue polarity, embryonic development, and tumorigenesis. Methods can be... Agent: Darby & Darby P.C.

20070072234 - Protein capable of binding plasticizer: The present invention provides a protein having a binding capacity to a plasticizer, which has been conferred with useful properties for measuring, quantifying, or concentrating a plasticizer, such as high sensitivity, low cross-reactivity, high tolerance for interferents, and high tolerance for solvents. Specifically, the present invention provides a modified protein... Agent: Edwards & Angell, LLP

20070072235 - Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways: The invention discloses 211 novel phosphorylation sites identified in signal transduction proteins and pathways underlying Anaplastic Large Cell Lymphoma (ALCL) involving the ALK-NPM translocation/fusion, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of... Agent: James Gregory Cullem, Esq. Intellectual Property Counsel

20070072238 - Wnt-frizzled chimera: The present invention relates to a Wnt-Frizzled chimera. The present invention also relates to pharmaceutical compositions that can be screened or developed using Wnt-Frizzled chimeras. The methods and pharmaceutical compositions of the present invention can be used to treat bone disorders and cancer.... Agent: Darby & Darby P.C.

20070072246 - Cell-based assays for determining drug action: Compositions and methods are provided for the classification of biologically active agents according to their effect on human biology, through the use of complex, primary human cell-based disease models in scalable assay formats. The systems of the invention utilize the simultaneous activation of multiple signaling pathways to generate and identify... Agent: Bozicevic, Field & Francis LLP

20070072248 - Constitutively activated human g protein coupled receptors: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown (“orphan GPCR receptors”), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.... Agent: Cozen O'connor, P.C.

20070072249 - Human cytokine and alpha-helix-containing polypeptides: This invention relates to new human alpha-helix-containing polypeptides, to methods of making such polypeptides, to methods of using them to treat immunological conditions, and to methods of identifying compounds that alter alpha-helix-containing polypeptide activities.... Agent: Immunex Corporation Law Department

20070072245 - Method and means for the determination of defined states or modifications in the mucus of the uterus or in the epithelium of other organs: The invention relates to a method and means for the determination of defined states or modifications in the mucus of the uterus or in the epithelium of other organs, especially for the diagnosis of pregnancy and diagnosis of embryo-implantation. In a biological sample, the concentration of human endometrial chorionic gonadotropin... Agent: Gudrun E. Huckett Draudt

20070072247 - Methods and reagents for the analysis and purification of polysaccharides: The disclosure provides fusion proteins comprising a carbohydrate recognition domain of an innate immunity receptor and a heterologous polypeptide. The fusion proteins of the disclosure may be used, for example, to fingerprint polysaccharide compositions and to purify polysaccharide compositions. Polysaccharide compositions include those isolated from Ganoderma lucidum (Reishi). The methods... Agent: Greenberg Traurig LLP

20070072243 - Multiplex screening for lysosomal sotrage disorders (lsds): A novel protein profiling method of testing for Lysosomal Storage Diseases (“LSD”) using discovered normalized lysosomal fingerprint patterns. The fingerprint patterns reveal the health of lysosomal organelles, specific LSD, and clinical severity Multiplexing bead technology for simultaneous screening of multiple LSD and normalizing measured enzyme activity or protein levels against... Agent: Jackson Walker LLP

20070072244 - Use of the endo-180 gene and polypeptide for diagnosis and treatment: This application is directed to a process of identifying a compound capable of modulating activity of a human ENDO180 receptor that comprises the steps of measuring the binding of the ENDO180 receptor to an interactor with which the ENDO180 receptor interacts specifically in vivo, in the absence or presence of... Agent: Cooper & Dunham, LLP

20070072251 - In vivo imaging using peptide derivatives: The present invention relates to the use of phage display LLG peptide derivatives as tumor targeting agents for diagnostic purposes, and to a method for targeting and imaging tumors and infections/inflammation. A diagnostic composition comprising said peptide derivatives is also disclosed.... Agent: Birch Stewart Kolasch & Birch

20070072250 - Method and system for analysis of cancer biomarkers using proteome image mining: The present invention provide a system and a method for detection of cancer, by producing a serum proteome standard by an image mining technique, and provide cancer-specific biomarkers. Disclosed is a method of analyzing cancer, comprising the steps of transforming serum proteomes from normal individuals and individuals having cancer into... Agent: Tanya A Arenson Medlen & Carroll

20070072252 - Method for the in vitro titration of an ncta application thereof in a method for the evaluation and/or monitoring of a biological product production method: The invention relates to a method for the in vitro titration of a non-conventional transmissible agent (NCTA), using transgenic cell lines. The invention also relates to: the application of the aforementioned in vitro titration method in a method for the in vitro evaluation and/or monitoring of the effectiveness of a... Agent: Birch Stewart Kolasch & Birch

20070072253 - Method of determining standard activity value of nattokinase: A method of determining a standard activity value of Nattokinase includes preparing a standard curve with respect to a plurality of Nattokinases having predetermined activity values by calculating corresponding dilution multiples using a standard essay, obtaining a sample curve with respect to an indeterminate Nattokinase by diluting the indeterminate Nattokinase... Agent: Hdsl

20070072254 - Manufacture of vitamin b6: A process for manufacturing a 3-unsubstituted, 3-monosubstituted or 3,3-disubstituted 9-acyloxy-1,5-dihydro-8-methylpyrido[3,4-e] [1,3]dioxepin (I) and optionally for manufacturing pyridoxine involves performing an addition reaction between a 4-methyl-5-alkoxy-oxazole (II) and a 2-unsubstituted, 2-monosubstituted or 2,2-disubstituted 4,7-dihydro-(1,3)-dioxepin (III) in the substantial absence of a solvent and a catalyst to give a product mixture consisting... Agent: Nixon & Vanderhye, PC

20070072256 - Optical molecular sensors for cytochrome p450 activity: The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the invention is a compound having the... Agent: Invitrogen Corporation C/o Intellevate

20070072255 - Toxicity detector for liquid consumable by humans: A process provides for testing for certain toxins and poisons in liquids, gases and solids that are consumed by humans or otherwise come in contact with humans. In the process, the material to be tested is mixed with aerobic microorganisms in a biomass to form a mixture. The mixture is... Agent: John C. Mcmahon

20070072257 - Multiwell plate assembly for use in high throughput assays: A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can... Agent: Knobbe Martens Olson & Bear LLP

20070072258 - Ultrasound-mediated high-speed biological reaction and tissue processing: Methods of fixing and processing tissue and samples on a membrane by using ultrasound radiation as a part of the method are presented. Ultrasound of a frequency in the range of 0.1-50 MHz is used and the sample or tissue receives 0.1-200 W/cm2 of ultrasound intensity. The use of ultrasound... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070072262 - Arg1, arg2, arg3, his1, his2, his5, his6 genes and methods for stable genetic integration: Novel genes encoding P. pastoris ARG1, ARG2, ARG3, HIS1, HIS2, HIS5 and HIS6 are disclosed. A method for inactivating alternately at least two biosynthetic pathways in a methylotrophic yeast is provided. A method for producing and selecting yeast strains characterized as being capable of genetic stable integration of heterologous sequences... Agent: Chang B. Hong

20070072260 - C1q related protein: This invention relates to the novel protein, termed INSP163, herein identified as a secreted protein containing a jelly-roll fold, in particular, as a member of the TNF (tumor necrosis factor)-like family of cytokines, specifically as a C1q-like protein and to the use of this protein and nucleic acid sequence from... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070072265 - Corynebacterium glutamicum genes encoding proteins involved in carbon metabolism and energy production: Isolated nucleic acid molecules, designated SMP nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SMP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20070072263 - Dna19355 polypeptide, a tumor necrosis factor homolog: A tumor necrosis factor homolog, identified as DNA19355, is provided. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided.... Agent: Genentech, Inc.

20070072259 - Fluorescent protein: An object of the present invention is to provide a novel fluorescent protein derived from favia favus. The present invention provides a fluorescent protein derived from favia favus having the following properties: (1) an excitation maximum wavelength is 507 nm; (2) a fluorescence maximum wavelength is 517 nm; (3) a... Agent: Greenblum & Bernstein, P.L.C

20070072261 - Nucleic acids encoding pak5 polypeptidesm and methods of use thereof: The present invention relates to the nucleic acid molecules encoding an STE20-related family of novel protein kinases, ZC1, ZC2, ZC3, ZC4, STLK2, STLK3, STLK4, STLK5, STLK6, STLK7, KHS2, SULU1, SULU3, GEK2, PAK4 and PAK5, segments and domains thereof, as well as various methods useful for the diagnosis and treatment of... Agent: Foley And Lardner LLP Suite 500

20070072270 - Polypeptide: We disclose a PS4 variant polypeptide derivable from a parent polypeptide, the parent polypeptide having non-maltogenic exoamylase activity, which PS4 variant polypeptide comprises one or more of the following substitutions: G69P, A141P, G223A, A268P, G313P, S399P and G400P, with reference to the position numbering of a Pseudomonas saccharophilia exoamylase sequence... Agent: Steptoe & Johnson LLP

20070072264 - Recombinant chimeric acetylcholine receptors and their derivatives recognized by cd4 t cells of myasthenic patients for the treatment of myasthenia gravis: The present invention relates to recombinant acetylcholine receptor polypeptides recognized by CD4 T cells of a myasthenia gravis patient and compositions for the treatment of myasthenia gravis containing the same as an effective ingredient, more precisely, recombinant acetylcholine receptor polypeptides deficient in B cell epitope, recombinant acetylcholine polypeptides in which... Agent: Joseph Hyosuk Kim, Ph.d. Jhk Law

20070072266 - Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof. therapeutic uses thereof: The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070072268 - Sulfotransferase and dna encoding the enzyme: A glycosaminoglycan 6-O-sulfotransferase having an activity of transferring sulfate to a hydroxyl at position 6 of a glycosamine residue of a glycosaminoglycan, which has a ratio of relative activities to substrates satisfying completely desulfated N-acetylated (CDSNAc) heparin/completely desulfated N-resulfated (CDSNS) heparin ≧0.05 and a molecular weight as calculated from constituent... Agent: Knobbe Martens Olson & Bear LLP

20070072267 - Transformant having galactose induction system and use thereof: The present invention provides a transformant having a gene expression inducing system having better responsiveness. The transformant of the invention has a galactose induction system and retains a coding region having a galactose induction system and encoding an assisting protein assisting transcription activation by a protein having the Gal4 activity... Agent: Oliff & Berridge, PLC

20070072269 - Ubiquitin-specific protease occurring in the brain and dna encoding the same: A ubiquitin-specific protease occurring in the brain and a DNA encoding it, which are useful for research on the molecular mechanism of the neuroplasticity expression and so on.... Agent: Choate, Hall & Stewart LLP

20070072271 - Method for the production of recombinant proteins: The present invention relates to a process for the production of recombinant polypeptides in leukocytes.... Agent: Novo Nordisk, Inc. Patent Department

20070072272 - Industrial method for producing rna and system for carrying out said method: The invention relates to an industrial method for producing an interest heterologous RNA and to a system for carrying out said production method consisting (1) in transforming mitochondrions of yeast cells free of mitochondrial RNA with a mitochondrial transcription vector comprising at least one copy of the DNA encoding said... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070072274 - Genes coding for metabolic pathway proteins: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.... Agent: Lahive & Cockfield, LLP

20070072273 - Genes encoding genetic stability, gene expression and folding proteins: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.... Agent: Lahive & Cockfield, LLP

20070072275 - Method for breeding lipid-producing fungus: It is intended to provide a breeding method whereby a lipid-producing fungus belonging to the genus Mortierella can be effectively and efficiently bred without resort to antibiotics. Transformation is carried out with the use of an auxotroph (for example, uracil auxotroph) of a fungus belonging to the Mortierella as a... Agent: Harness, Dickey & Pierce, P.L.C

20070072276 - Method for separating, extracting and purifying poly-beta-hydroxyalkanoates (phas) directly from bacterial fermentation broth: The invention discloses a method for directly separating and purifying polyhydroxyalkanoates in cells from fermentation liquid and it relates to the field of posttreatment technology of biological engineering. The method includes following steps: pretreating fermentation liquid with physical method for breaking cell wall; adjusting pH value of pretreated fermentation liquid... Agent: Butzel Long

20070072277 - Process for producing glutamate derivatives: The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070072278 - Reductase gene and use thereof: Provided are genes coding a protein having an ability of asymmetrically reducing a 2-oxo-4-phenylbutyrate to produce a (R)-2-hydroxy-4-phenylbutyrate advantageously from the industrial standpoint, the protein, and methods of producing a (R)-2-hydroxy-4-phenylbutyrate using them. Genes having a base sequence coding an amino acid sequence shown in SEQ ID NO:1, or a... Agent: Akin Gump Strauss Hauer & Feld L.L.P.

20070072279 - Evolved micro-organisms for the production of 1,2-propanediol: The present invention concerns a new method of preparation of a strain of evolved micro-organisms for the production of 1,2-propanediol by the metabolism of a simple carbon source, which method comprises the growth under selection pressure in an appropriate growth medium containing a simple carbon source of an initial bacterial... Agent: Dorsey & Whitney LLP Intellectual Property Department

20070072280 - Materials and methods for the efficient production of xylitol: Novel microorganisms are provided that efficiently convert xylose (or xylulose) alone or in combination with a carbon substrate to produce xylitol. In certain embodiments, E. coli are engineered to include a mutant crp gene as well as deletion of the xylB gene. The microorganisms of the invention are particularly advantageous... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070072281 - Three-dimensional structure of the catalytic domain of protein kinase c theta, methods and uses thereof: The present invention concerns protein kinase C (PKC) theta, in particular, the three-dimensional structure of the catalytic domain of PKC theta. Methods of expression, purification and crystallization of PKC theta catalytic domain are provided in preparation for crystallography. The atomic coordinates of a complex of PKC theta complexed with an... Agent: Novartis Corporate Intellectual Property

20070072282 - Bovine adeno-associated viral (baav) vector and uses thereof: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.... Agent: National Institute Of Health C/o Needle & Rosenberg, P.C.

20070072283 - Nitrite-type nitrification carrier and method for producing the same and method and apparatus for removing nitrogen using the same: Provided are a nitrite-type nitrification carrier and a method for producing the same and a method and an apparatus for removing nitrogen using the same, in which the quantity of organic matter to be added can be substantially reduced to reduce running cost. A method for producing a nitrite-type nitrification... Agent: Oliff & Berridge, PLC

20070072284 - Nitrite-type nitrification carrier and method for producing the same and method and apparatus for removing nitrogen using the same: Provided are a nitrite-type nitrification carrier and a method for producing the same and a method and an apparatus for removing nitrogen using the same, in which the quantity of organic matter to be added can be substantially reduced to reduce running cost. A method for producing a nitrite-type nitrification... Agent: Oliff & Berridge, PLC

20070072285 - Fluid interface for bioprocessor systems: An apparatus and method for an aseptic fluidic interface between bioprocess systems is provided. The apparatus includes an inlet valve, adapted for automatic control, that is coupled to a biofluid source site. A sampling conduit extends from the inlet valve to an outlet valve. The outlet valve is adapted for... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070072287 - Biomems cartridges: A cartridge includes a first layer to receive a printed circuit board hosting a biochip. A second layer is connected to the first layer and is configured for sample injection to the biochip. The second layer includes a first septum to isolate fluidic ports. A third layer is connected to... Agent: Cooley Godward Kronish LLP

20070072286 - Label-free detection of biomolecules: The invention provides a method and a device for label-free detection of biomolecules or analytes in a sample liquid. The method comprises the steps of allowing an analyte to bind to one of at least two conductive surfaces. An alternating electrical field between at least two conductive surfaces. Amplitude and... Agent: Philips Intellectual Property & Standards

20070072288 - Cell culture apparatus and a fabricating method of the same: A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by photolithography, wherein the biomaterial composite layer contains two gel materials. One is a bio-compatible hydrogel composition having various weight ratio of:2-hydroxyethylmathacrylate(HEMA),bisphenolA... Agent: Bacon & Thomas, PLLC

20070072289 - Application apparatus of 3-dimensional klinostat and growing method using the same: In an application apparatus of a klinostat, an object is encapsulated in a vessel. A rotating unit rotates the vessel around n axes (n is an integer more than 1) such that gravity is equally applied to the object. A fluid supply unit supplies fluid into the vessel, while the... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070072290 - Microstructure for particle and cell separation, identification, sorting, and manipulation: The invention relates to microscale cell separating apparatus which are able to separate cells on the basis of size of the cells, interaction of the cells with surfaces of the apparatus, or both. The apparatus comprises a stepped or sloped separation element (16) interposed between an inlet region (20) and... Agent: Duane Morris, LLPIPDepartment

20070072291 - Dedifferentiated, programmable stem cells of monocytic origin, and their production and use: The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for... Agent: David R. Marsh Arnold & Porter

20070072292 - Epha4-positive human adult pancreatic endocrine progenitor cells: The invention relates to the discovery of a selective cell surface marker that permits the selection of a unique subset of pancreatic stem cells having a high propensity to differentiate into insulin-producing cells or into insulin-producing cell aggregates.... Agent: Townsend And Townsend And Crew, LLP

20070072293 - Process for stabilization of bacterial cells: Biocompatible medium and non-ionic polymer surfactants such as tyloxapol may be used in a composition for preserving cells, such as bacterial cells. Cells may be preserved, for example, by suspending them in a biocompatible medium containing tyloxaopol and preserving the suspension. Examples of a preservation procedure are drying by foam... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070072294 - Use of human stem cells and/or factors they produce to promote adult mammalian cardiac repair through cardiomyocyte cell division: A method for treating a subject afflicted with a cardiac disorder, in vivo, comprising (i) producing a solution comprising media conditioned from the culture of cells, in vitro, and (ii) administering the solution of step (i) to the subject, thereby treating the cardiac disorder in the subject. Methods for determining... Agent: Kenyon & Kenyon LLP

20070072295 - Multipotent lymphohematopoietic progenitor cells: This invention relates to hematopoietic precursors derived from human embryonic stem cells. In the culture of differentiated cells from human ES cells, the fully committed hematopoietic precursors are CD34+ and CD43+ but not CD45+. If the cells are cultured until they express CD45, then the cells lose the ability to... Agent: Quarles & Brady LLP

20070072296 - C/ebpalpha gene targeting constructs and uses thereof: A DNA construct for the expression of a functional mammalian C/EBPα comprising the following components: (i) a first region having homology with an endogenous tumor-specific promoter gene sequence of a gene locus (ii) a DNA molecule encoding the C/EBPα; and (iii) a second region having homology with a region within... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070072297 - Method for ligating nucleic acids and molecular cloning: The invention provides methods of covalently joining nucleic acid molecules and methods of molecular cloning. The methods provide either sequential or simultaneous ligation of flanking or vector nucleic acid molecules to nucleic acid insert molecules by topoisomerase and DNA ligase. The methods provide for directional and non-directional covalent joining and... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070065805 - Cell migration assay: The present invention provides compositions and methods for preparation of a three-dimensional transendothelial cell migration (TEM) assay. These compositions and methods are uniquely suited for the high throughput TEM assay, and for the analysis and identification of TEM mediators which inhibit or stimulate this process. The composition for detecting migration... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070065801 - Diagnostics and therapeutics for diseases associated with 5-hydroxytryptamine (seotonin) receptor 4 (5-ht4): The invention provides a human 5-HT4 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver... Agent: Banner & Witcoff

20070065806 - Gel spot picker: The present invention relates to a gel sheet (1) for use in a spot picker device wherein said gel sheet is provide with reference marks (5′-5′″) which can be used to determine if the gel sheet (1) has been deformed between the stages of scanning the gel sheet and picking... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20070065808 - Method and apparatus for sorting particles: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing... Agent: Lahive & Cockfield, LLP

20070065802 - Method and system for measuring the penetration of drugs and other substances into tissue: The failure of many anticancer drugs to control growth of solid cancers may stem in part from inadequate delivery to tumor regions distant from vasculature. However, extricating the effect of tissue penetration from the many other factors that affect a drug's efficacy in tumors with distance from vasculature is generally... Agent: Oyen, Wiggs, Green & Mutala LLP 480 - The Station

20070065804 - Method for pr-39 peptide mediated selective inhibition of ikappabalpha degradation: The present invention provides both a method and means for regulating IκBα degradation, NFκB activity, and NFκB-dependent gene expression within living cells, tissues, and organs in-situ. The selective regulation is performed using native PR-39 peptide or one of its shorter-length homologs, for interaction with such IκBα and proteasomes as are... Agent: Licata & Tyrrell P.C.

20070065807 - Method of preparing basement membrane, method of constructing basement membrane specimen, reconstituted artificial tissue using the basement membrane specimen and process for producing the same: The object of the present invention is to provide the following: a method for preparing a basement membrane which is extracellular matrices having a function to control morphology, differentiation, proliferation, motility, function expression and the like of cells; a method for constructing a specimen of a basement membrane; a process... Agent: Frommer Lawrence & Haug

20070065803 - Patterns for a skeletal system: The present invention relates to a bone system model comprising a mineralized matrix and osteoblasts, chararacterized in that the osteoblasts are deposited onto the matrix so as to form a layer at confluence and/or nodules, and the osteoclasts are deposited onto said layer and/or said nodules, and also to bone... Agent: Buchanan, Ingersoll & Rooney PC

20070065813 - Assay for quantitative detection of respiratory syncytial virus (rsv): The present invention describes respiratory syncytial virus (RSV) primers and probes as reagents for detection of a RSV infection. Specifically, the invention provides nucleic acid sequences from the RSV nucleocapsid gene used with hybridization and PCR techniques to detect RSV infection.... Agent: Licata & Tyrrell P.C.

20070065809 - Compositions and methods screening using populations of surrogate antibodies: Methods and compositions for the detection, identification, and quantification of compounds of interest in a sample are provided. The compositions and methods include arrays and kits comprising a population of surrogate antibodies that bind compounds of interest. The surrogate antibodies can be immobilized on to a solid support by means... Agent: Alston & Bird LLP

20070065814 - Detecting foot-and-mouth disease virus: This document relates to methods and materials involved in determining whether or not an animal contains a foot-and-mouth disease virus. For example, nucleic acid primer pairs, combinations of nucleic acid primer pairs, nucleic acid arrays (e.g., diagnostic cards) containing nucleic acid primer pairs or combinations of nucleic acid primer pairs,... Agent: Fish & Richardson P.C.

20070065810 - Diagnosis and treatment of cervical cancer: In certain aspects, the invention relates to methods of diagnosing cervical cancer by using a combination of certain biomarkers such as hTERT, IGFBP-3, transferrin receptor, beta-catenin, Myc-HPV E6 interaction, HPV E7, and telomere length. In other aspects, the invention relates to methods of detecting immortalization of cervical cells by using... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20070065811 - Method of detecting multiple analytes: The invention relates to a a microtiter plate and its use in a method of the invention, which microtiter plate comprises a plurality of containers, wherein the bottom of each container comprises a (semi-)permeable membrane capable of directly or indirectly binding an analyte, and wherein each container is separated from... Agent: Ladas & Parry

20070065815 - Methods for genotyping hepatitis c virus: The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those... Agent: Medlen & Carroll, LLP

20070065812 - Multiplexed rt-pcr assay for detection and separation of barley and cereal yellow dwarf viruses: RT-PCR primer multiplexes and a method for detecting the presence of Subgroup I and II barley or cereal yellow dwarf viruses in a sample. A first multiplex includes a first primer pair that selectively amplifies Subgroup I viruses, and a second primer pair that selectively amplifies Subgroup II viruses. A... Agent: Price Heneveld Cooper Dewitt & Litton, LLP

20070065848 - 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206, and 8843 molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305, 14911, 86216, 25206 and 8843 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 26199, 33530, 33949, 47148, 50226, 58764, 62113, 32144, 32235, 23565, 13305,... Agent: Millennium Pharmaceuticals, Inc.

20070065860 - Accelerated class i and class ii hla dna sequence-based typing: There is provided a method for directly typing or sequencing HLA class I or class II alleles from a tissue sample wherein at least one exon of the HLA class I or class II alleles from the sample is amplified in a locus specific manner utilizing two primers, wherein at... Agent: Dunlap, Codding & Rogers P.C.

20070065872 - Apparatus and methods for detecting dna in biological samples: Apparatus and methods are described for detecting target DNA in a biological sample using capture probes and electrically-assisted hybridization. The reaction cell is formed with an attachment surface of aluminum oxide for better thermal and physical properties, and the aluminum oxide surface is coated with anti-DIG antibody to provide a... Agent: Buchanan, Ingersoll & Rooney PC

20070065855 - Biochip and analytical instrument for analyzing same: There is provided a biochip capable of quantitatively grasping hybridization efficiency. In the biochip comprising a plurality of probe sites with target molecules bonded thereto, respectively, the probe sites disposed thereon, the marker sites with a known number of fluorescent molecules bonded thereto, respectively, are disposed. With the biochip, the... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20070065858 - Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors: The present invention provides diagnostic and prognostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor. Methods are provided for predicting the sensitivity of tumor cell growth to inhibition by an IGF-1R kinase inhibitor, comprising assessing whether the tumor cell has undergone an... Agent: Osi Pharmaceuticals, Inc.

20070065826 - Cationic dye compound for detecting nucleic acid double strand, and detection method and apparatus using same: A cationic dye compound having novel uses, the cationic dye compound being capable of conveniently and rapidly detecting a nucleic acid double strand, and a detection method using the cationic dye compound are provided. This invention relates to a cationic dye compound for detecting a nucleic acid double strand, comprising:... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070065836 - Chromosome 1p36 polymorphisms and low bone mineral density: The invention provides methods and compositions for diagnosing risk of low BMD and risk of osteoporosis based on the detection of SNP identity for human chromosome 1p36 polymorphisms designated in the NCBI SNP database (dbSNP) as rs2794328, rs446529, rs397559 and rs1802353.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20070065830 - Cloning multiple control sequences into chromosomes or into artificial centromeres: Artificially synthesizing 29 homozygous cystic fibrosis core panel controls demonstrates placing multiple homozygous mutant sequences on the same single control DNA sequence to streamline quality control by minimizing extra control assays, time, and costly formatted test materials and testing all controls during every test. Any rare or unavailable reported DNA... Agent: Brouse Mcdowell Lpa

20070065874 - Compositions and methods comprising control nucleic acid: The present invention relates, in part, to control nucleic acid molecules having no significant sequence homology to any known nucleic acid, and predefined G/C-content. The present invention further relates to method of using control nucleic acid molecules to validate microarray analyses, compositions comprising control nucleic acid molecules, and kits comprising... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070065866 - Compositions and methods for suppressing fibrocytes: The present invention relates to the ability of anti-FcγR antibodies to suppress fibrocytes. Methods and compositions for suppressing fibrocytes are provided. These methods are useful in a variety of applications including treatment and prevention of conditions resulting from fibrosis in the liver, kidney, lung, heart and pericardium, eye, skin, mouth,... Agent: Michelle Lecointe Baker Botts L.L.P.

20070065832 - Computer-implemented biological sequence identifier system and method: A computer-implemented biological sequence identifier (CIBSI) system and method for selecting a subsequence from biological sequence data according to at least one selection parameter. The at least one selection parameter corresponds to a likelihood of returning a meaningful result from a similarity search.... Agent: Naval Research Laboratory Associate Counsel (patents)

20070065847 - Degeneratively labeled probes: The invention is directed to methods for determining whether any of group of analytes of interest are present in a sample, and optionally, in at least one subsequent determination, which of the analytes are present. The invention is also directed towards methods for the rapid and efficient determination of the... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070065842 - Detection of survivin in the biological fluids of cancer patients: The present invention includes a method for diagnosing cancer comprising detecting the presence of survivin in the biological fluid of a patient. The present invention also provides kits comprising one or more agents that detect survivin polypeptide or survivin nucleic acid and a container for collecting biological fluid for testing.... Agent: Morgan Lewis & Bockius LLP

20070065825 - Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed: The present invention is related to a device, kit and method for pulsing a biological sample with a pulsing agent and subsequently stabilizing the biological sample so pulsed. The invention has application in the fields of medical diagnostics, particularly relating to immunity.... Agent: Knobbe Martens Olson & Bear LLP

20070065835 - Dna fingerprinting using a branch migration assay: A method of determining the length of a polynucleotide target is provided. With this method, a target is first hybridized to an array of first probes having different, determined lengths, resulting in the formation of duplexes between the polynucleotide target and the first probes. These duplexes have a single stranded... Agent: Lumen Intellectual Property Services, Inc.

20070065831 - Function and regulation of adamts-1: The present invention relates to ADAMTS-1 and uses thereof. The present invention also relates to fragments of ADAMTS-1 and methods of inhibiting cell growth and metastasis. The present invention also provide methods of identifying inhibitors and activators relating to the function of ADAMTS-1.... Agent: Cozen O'connor, P.C.

20070065827 - Gene expression profiles and methods of use: The present invention relates to gene expression profiles, microarrays comprising nucleic acid sequences representing gene expression profiles, and methods of using expression profiles and microarrays. The invention also provides methods and compositions for diagnostic assays for detecting cancer and therapeutic methods and compositions for treating cancer. The invention also provides... Agent: Jeffrey M. Greenman

20070065845 - Gene expression profiling in biopsied tumor tissues: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon... Agent: Heller Ehrman LLP

20070065846 - Gene expression profiling in biopsied tumor tissues: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. Th invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon... Agent: Heller Ehrman LLP

20070065852 - Hiv recombinant vaccine: Reagents and methods for making and using HIV recombinant vaccines are disclosed.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070065873 - Human t2r55 taste receptor and related assays for identifying human bitter taste modulators: The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R55 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor.... Agent: Hunton & Williams LLP Intellectual Property Department

20070065870 - Human t2r67 taste receptor and related assays for identifying human bitter taste modulators: The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R67 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor.... Agent: Hunton & Williams LLP Intellectual Property Department

20070065871 - Human t2r71 receptor and related assays for identifying human bitter taste modulators: The present invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R71 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor.... Agent: Hunton & Williams LLP Intellectual Property Department

20070065868 - Il-17 receptor like molecules and uses thereof: Novel IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17... Agent: Marshall, Gerstein & Borun LLP

20070065829 - In vitro differentiation of vascular smooth muscle cells, methods and reagents related thereto: This invention is directed to an in vitro system for rapidly and uniformly inducing immortalized neural crest cells to differentiate to vascular smooth muscle cells. As excessive proliferation of vascular smooth muscle cells is a phenotypic response to the development of occlusive arteriosclerotic disease, the in vitro system of this... Agent: Foley Hoag, LLP Patent Group (w/huv Hmv)

20070065820 - Lipid-associated molecules: Various embodiments of the invention provide human lipid-associated molecules (LIPAM) and polynucleotides which identify and encode LIPAM. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of LIPAM.... Agent: Foley And Lardner LLP Suite 500

20070065876 - Marking: The invention provides a marking system, markers and methods of use of such marking systems and markers which enable unique marking of articles and subsequent detection of that marking. In particular the invention provides a marking system, the marking system comprising a plurality of different DNA fragment types, each of... Agent: Merchant & Gould PC

20070065864 - Message abundance and allele copy number determination using ivt with single-stranded primer-promoter-selector constructs: Disclosed is a single stranded primer-promoter-selector construct comprising (in 3′ to 5′ orientation) a primer subsequence annealing to the target, a T7 or other promoter subsequence (the template strand), and a selector subsequence. The primer can be extended by template mediated elongation, including reverse transcription, or ligation to another oligonucleotide.... Agent: Eric P. Mirabez

20070065823 - Method and compositions for detection and enumeration of genetic variations: Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single particle to... Agent: Banner & Witcoff

20070065834 - Method and sequences for determinate nucleic acid hybridization: Provided are methods for using nucleic acid sequences having two or more degenerately pairing nucleotides, each degenerate nucleotide having a partially overlapping set of complementarity, to reduce the number of hybridizing nucleotide sequences or probes used in biochemical and molecular biological operations having sequence specific hybridization. The method may be... Agent: Searete LLC Clarence T. Tegreene

20070065851 - Method for detecting a microorganism in a fecal specimen: The invention relates to detecting microorganisms in specimens for the purposes of inter alia diagnoses, screenings, quarantine inspections, and clinical tests. Specifically, it relates to detecting and quantifying enteropathogenic bacteria in a fecal specimen, including Shigella species, Salmonella species, Campylobacter species, enterohemorrhagic E. coli or Verocytotoxin-producing E. coli, Vibrio cholerae,... Agent: Trask Britt

20070065863 - Method for detecting a risk of cardiovascular disease: Single nucleotide polymorphisms associated with serum C-reactive protein levels are disclosed. Also disclosed are methods of using these markers to predict the propensity for cardiovascular diseases and the time to first myocardial infarction.... Agent: Quarles & Brady LLP

20070065850 - Method for diagnosis of heart failure: A method