Chemistry: molecular biology and microbiology inventions 02/07

20070042337 - Isochoric method and device for reducing the probability of ice nucleation during preservation of biological matter at subzero centigrade temperatures: Because ice-I is less dense than water, the formation of an ice nucleus in an isochoric (constant volume) system containing water at pressures lower than about 200 MPa will cause an increase in pressure. This increase in pressure increases the energy required for reducing the probability for ice nucleation in... Agent: Gordon & Rees LLP

20070042341 - Biodegradable polymer-ligand conjugates and their uses in isolation of cellular subpopulations and in cryopreservation, culture and transplantation of cells: The invention discloses a biodegradable particle-cell composition having at least one biodegradable particle, at least one receptive group covalently linked thereto, and a cell anchored thereto. The particle can be polylactide, a polylactide-lysine copolymer, polylactide-lysine-polyethylene glycol copolymer, starch, or collagen. The receptive group can be an antibody, a fragment of... Agent: Foley And Lardner LLP Suite 500

20070042340 - Method and apparatus for protecting biological specimens: A biological specimen is preserved by surrounding the biological specimen with a protective enclosing structure. The protective enclosing structure reacts with corrosive components in the surrounding atmosphere or environment to reduce their degradative effect and also protects the preparations from bacterial and fungal growth.... Agent: Fish & Richardson P.C.

20070042338 - Method for storing tumor cells: The present invention relates to a method for storing cells, wherein the cells are stored in a composition comprising a base nutritive medium and liposomes at temperatures in the range of −196° C. to 37° C., characterized in that the liposomes comprise one or more sterols and that the cells... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20070042339 - Preservation of biomaterials with transported preservation agents: Biomaterial are preserved by exposing them to a preservation agent having preservation properties. The biomaterial has at least one transporter that allows uptake of the preservation agent into the biomaterial for loading the biomaterial with the preservation agent to an intracellular concentration sufficient for preserving the biomaterial. The preservation agent... Agent: Nutter Mcclennen & Fish LLP

20070042342 - Separation systems of frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations: Devices, compositions, and methods for handling, separating, packaging, and utilization of spermatozoa (1) that can be derived from previously frozen sperm samples collected from a male mammal. Specifically, techniques to uniformly stain (2) spermatozoal DNA even when derived from previously frozen sperm and separation techniques to separate and isolate spermatozoa... Agent: Santangelo Law Offices, P.C.

20070042344 - Differentiation regulating agent containing gene which regulating differentiation from stem cells into natural killer cells as effective ingredient: The present invention relates to a cell differentiation regulating agent containing a gene regulating differentiation from stem cells into natural killer cells as an effective ingredient, more precisely, a cell differentiation regulating agent containing a gene regulating differentiation from stem cells into premature natural killer cells as an effective ingredient... Agent: Jhk Law

20070042343 - Forward mutation assay based on 5-fluorouracil resistance: Disclosed herein is a novel forward mutation assay based on 5-fluorouracil (5-FU) resistance which utilizes a strain of Salmonella typhimurium derived from the Ames strain TA100. More specifically, the invention provides a high throughput alternative to the standard Ames mutation assay for the evaluation of the genotoxicity activity of compounds... Agent: Merck And Co., Inc

20070042347 - High throughput biological heart rate monitor that is molecularly determined: This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells, each 3 mm by 3 mm in inner diameter. Cardiac myocytes disaggregated from neonatal animals are plated onto the bottom of each well and... Agent: Kenyon & Kenyon LLP

20070042346 - Method and apparatus for detection of rare cells: Fluorescent dye-tagged rare cells are disposed in a biological fluid layer contained in an annular gap (12) between an inside test tube wall (14) and a float wall (16). One or more analysis images are acquired at one or more focus depths using a microscope system (10, 10′, 10″, 10′″).... Agent: Fay, Sharpe, Fagan, Minnich & Mckee, LLP

20070042345 - Polypeptide having intracellular calcium ion indicator function: The present invention provides a polypeptide having an intracellular calcium ion indicator function, which contains the following elements (a)-(c): (a) a polypeptide residue consisting of a membrane localization signal sequence; (b) a first fluorescent polypeptide residue; and (c) a second fluorescent polypeptide residue in the order of (a), (b) and... Agent: Leydig Voit & Mayer, Ltd

20070042359 - Binding molecules capable of neutralizing west nile virus and uses thereof: The invention provides human binding molecules specifically binding to West Nile virus and having West Nile virus neutralizing activity, nucleic acid molecules encoding the human binding molecules, compositions comprising the human binding molecules and methods of identifying or producing the human binding molecules. The human binding molecules can be used... Agent: Trask Britt

20070042348 - Colorimetric sensor: A means for detecting a presence of a particular material in the air, a filter for an air conditioner which can confirm the presence of the particular material in the air, and a method for confirming a performance of the filter for an air conditioner about a removal of the... Agent: GlobalIPCounselors, LLP

20070042354 - Detecting pathogens in companion animals: This document relates to methods and materials involved in determining whether or not an animal contains a pathogen. For example, nucleic acid primer pairs, combinations of nucleic acid primer pairs, nucleic acid arrays (e.g., diagnostic cards) containing nucleic acid primer pairs or combinations of nucleic acid primer pairs, methods for... Agent: Fish & Richardson P.C.

20070042357 - Detection and identification of bacterial strains: The present invention relates to a method to detect bacteria, the method comprising the following steps: coupling of the bacteriophages and/or bacteriophage proteins to a support, incubating the support coupled with the bacteriophages and/or bacteriophage proteins with a sample, optionally removing the sample and the bacteria in the sample not... Agent: Fulbright & Jaworski L.L.P.

20070042353 - Hcv polymerase suitable for crystal structure analysis and method for using the enzyme: An HCV polymerase suitable for crystal structural analysis and a method for using the enzyme are provided. The HCV polymerase suitable for crystal structural analysis and/or comprising high HCV polymerase activity can be used for the three-dimensional structural analysis, and for rational identification of HCV polymerase inhibitors by computers. The... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070042355 - Integrated method for collection and maintenance of detectability of a plurality of microbiological agents in a single clinical sample and for handling a plurality of samples for reporting a sum of diagnostic results for each sample: A method and kit related thereto are described for the collection and maintenance of detectability of a plurality of species of microbiological agents in a single clinical sample as well as an integral method for handling a plurality of the samples and managing information associated therewith for reporting a sum... Agent: Medical Diagnostic Laboratories LLC

20070042358 - Method for improving cell permeability to foreign particles: The present invention provides a method for allowing foreign particles to penetrate, very efficiently, the cell wall, cell membrane, organelle membrane and/or nuclear membrane of a cell and hybridizing or binding to the complimentary target in the cell. The cells may be from a culture or from specimens obtained from... Agent: Kevin Farrell Pierce Atwood

20070042350 - Methods and compositions for detecting sars virus and other infectious agents: This invention relates generally to the field of virus detection. In particular, the invention provides chips, probes, primers, kits and methods for amplifying and detecting SARS-CoV nucleotides sequence. The clinical and other uses of the present chips, probes, primers, kits and methods are also contemplated.... Agent: Morrison & Foerster LLP

20070042349 - Methods for assessing biologic diversity: Methods for determining biologic diversity (e.g., lymphocyte receptor diversity or diversity of viral quasispecies) in a subject are described, as well as methods for monitoring a disease in a subject.... Agent: Fish & Richardson P.C.

20070042351 - Multi-allelic molecular detection of sars-associated coronavirus: The subject invention relates to a multiple-allelic RT-real-time polymerase chain reaction (PCR) assay for coronaviruses including the SARS virus. Multiple target sequences within the SARS-CoV, S, E, M and N genes are identified. The use of the four different targets enhances the likelihood that the fundamental genetic drift of the... Agent: Venable LLP

20070042352 - Retroviral vector and cell-based assay for measuring the mutations rate of retroviruses employing same: Lentiviral-based retrovirus vectors and an in vivo mutation rate assay employing them. More particularly, an assay for directly determining the in vivo mutation rate of HIV-1.... Agent: Dinsmore & Shohl LLP

20070042356 - Variants of hepatitis b virus resistant against some nucleoside analogues, but sensitive to others, and uses thereof: The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues both in vivo and in vitro. More in particular, reverse transcriptase mutant rt I233V is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in... Agent: Nixon & Vanderhye, PC

20070042415 - Anti-fused antibodies: The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, immunoadhesins, agonists and antagonists (including antibodies) to human & vertebrate fused.... Agent: Genentech, Inc.

20070042394 - Apparatus for producing a dna doped carbon cluster and method for producing the same: The object of the present invention is to provide an apparatus for producing a DNA doped carbon cluster capable of introducing DNA into the cavity of a carbon cluster. An apparatus for producing a DNA doped carbon cluster comprising a radio frequency current applying electrode which is composed of a... Agent: Young & Thompson

20070042365 - Assay for detecting methylation changes in nucleic acids using an intercalating nucleic acid: A method for detecting the presence of a target nucleic acid in a sample including treating a sample containing nucleic acid with an agent that modifies unmethylated cytosine; providing to the treated sample a detector ligand in the form of an intercalating nucleic acid (INA) capable of binding to a... Agent: Knobbe Martens Olson & Bear LLP

20070042380 - Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof: The present invention relates to a first group of novel oligonucleotides, here identified as “Genomic Address Messenger” or “GAM” oligonucleotide, and a second group of novel operon-like polynucleotides, here identified as “Genomic Record” or “GR” polynucleotide. GAM oligonucleotides selectively inhibit translation of known “target” genes, many of which are known... Agent: Howrey LLP

20070042381 - Bioinformatically detectable group of novel regulatory viral and viral associated oligonucleotides and uses thereof: The present invention relates to a first group of novel viral and human associated oligonucleotides, here identified as “Genomic Address Messenger” or “GAM” oligonucleotide, and a second group of novel operon-like viral and human polynucleotides, here identified as “Genomic Record” or “GR” polynucleotide. GAM oligonucleotides selectively inhibit translation of known... Agent: Howrey LLP

20070042399 - Biological materials and uses thereof: The invention relates to a library, methods of making a library of biologically active molecules and uses thereof. The library comprises a plurality of chelating ligand pairs, each said ligand pair including two ligands that bind specifically to distinct epitopes on the same target molecule and the two ligands of... Agent: Patrea L. Pabst Pabst Patent Group LLP

20070042377 - Biosensor: A sensor for determining the presence of an analyte in a test sample, said sensor comprising a nanoparticulate membrane comprising nanoparticles of at least one inorganic oxide of an element selected from Group IA, IIA, IIIA, IVA, IB, IIB, IIIB, IVAB, VB, VIB, VIII3 or VIIII3 of the Periodic Table,... Agent: Intellectual Property / Technology Law

20070042404 - Compositions and method for detecting endonuclease activity: The present invention relates to compositions and a cell-based assay for detecting endonuclease activity. The assay involves the basic principle of linking a endonuclease cleavage event with cell survival. When an endonuclease cleaves its cognate endonuclease recognition site located on a vector containing a toxic reporter protein, the vector is... Agent: Licata & Tyrrell P.C.

20070042398 - Cyanine dyes and methods of use: The present invention provides for cyanine dyes as near IR quenchers. The cyanine dyes have absorption wavelengths in the near-infrared region of about 650-900 nm and are essentially non-fluorescent. The dyes of the invention have at least one linking group. The present invention also provides substantially non-fluorescent, NIR probes. Biological... Agent: Townsend And Townsend And Crew, LLP

20070042416 - Dendritic enriched secreted lymphocyte activation molecule: The present invention relates to a novel human protein called Dendritic Enriched Secreted Lymphocyte Activation Molecule, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20070042368 - Detection and monitoring of lung cancer: Compositions and methods for the diagnosis of lung cancer are disclosed. Such methods are useful to detect early tumors or provide adequate stage/grade information or tumor specificity. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Such compositions may be used,... Agent: Seed Intellectual Property Law Group PLLC

20070042412 - Detection of biologically active compounds: A probe comprises a supramolecular structure having a chemical or biological recognition moiety; a phosphorescent reporter label; and an effector which interacts with the label so that the probe alters its phosphorescent characteristics on recognition of a target. The phosphorescent reporter label may have an emission lifetime in the order... Agent: Jacobson Holman PLLC

20070042419 - Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions: The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the... Agent: Nixon Peabody LLP - Patent Group

20070042406 - Diffusion mediated clean-up of a target carrier fluid: Microfludic channels are constructed for use in preparing and/or analyzing samples. In one embodiment, a microfluidic channel receives a carrier fluid having both non-targets and targets. The non-targets are moved from the carrier fluid by diffusion and into sheathing fluids also present in the channel before contents of the carrier... Agent: Wolf Greenfield & Sacks, PC

20070042393 - Discrimination method of target base in dna, and allele specific primer used in the method of the same: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is A, while a base adjacent with one... Agent: Mcdermott Will & Emery LLP

20070042405 - Enhanced diagnostic multimarker serological profiling: The present invention is related to methods of early diagnosis of ovarian cancer in a patient by determining serum levels of blood markers using a novel LabMAP™ technology (Luminex Corp., Austin, Tex.), which allows for simultaneous measurement of the blood markers in serum. The panel of blood markers offers extremely... Agent: The Webb Law Firm, P.C.

20070042395 - Fibroblast growth factor-19 (fgf-19) nucleic acids and polypeptides and methods of use for the treatment of obesity: The present invention is directed to novel polypeptides belonging to the fibroblast growth factor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide... Agent: Genentech, Inc.

20070042370 - Fluorescent substrates for detecting organophosphatase enzyme activity: Disclosed are compounds of the formula (I): wherein R3, R4, R5, R9, and R10 are selected from the group consisting of H and groups or atoms other than H, and R6 and R8 are halo or hydrogen; X1, X2, and X3 are independently O or S; provided that R9 and... Agent: Foley And Lardner LLP Suite 500

20070042382 - Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof: The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by such nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and proteins, and methods... Agent: Celera Genomics Corp. Attn: Wayne Montgomery, Vice Pres, Intel Property

20070042361 - Human secreted proteins: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cancer and other hyperproliferative diseases and disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and... Agent: Human Genome Sciences Inc Intellectual Property Dept.

20070042386 - Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system: The present invention contemplates monitoring the amplification of nucleic acid using chromophore-containing polynucleotides having at least two donor chromophores operatively linked to the polynucleotide by linker arms, such that the chromophores are positioned by linkage along the length of the polynucleotide at a donor-donor transfer distance, and at least one... Agent: O'melveny & Myers LLP Suite 100

20070042375 - Isolated berovin photoprotein and use thereof: The invention relates to the photoprotein berovin, to its nucleotide and amino acid sequences and to the activity and use of the photoprotein berovin.... Agent: Banner & Witcoff

20070042367 - Lab-on-chip system for analying nucleic acid: This invention relates generally to the field of nucleic acid detection. In particular, the invention provides a lab-on-chip system for analyzing a nucleic acid, which system comprises, inter alia, controllably closed space, and a target nucleic acid can be prepared and/or amplified, and hybridized to a nucleic acid probe, and... Agent: Morrison & Foerster LLP

20070042420 - Liver tumor marker sequences: Polypeptides whose expression is upregulated in liver tumor cells and cells from liver preneoplastic foci relative to expression in normal liver cells are disclosed as are polynucleotides that encode the polypeptides. In humans, the polynucleotide maps to a region of chromosome 15. The overexpression has also been confirmed in human... Agent: Quarles & Brady LLP

20070042409 - Mammalian obestatin receptors: A high affinity obestatin receptor is provided; the orphan receptor GPR39. The receptor mediates obestatin activities. The obestatin receptor (GPR39) and fragments thereof, particularly soluble fragments thereof, are useful as therapeutic agents capable of inhibiting the action of obestatin. In addition to use as a therapeutic agent, GPR39 polypeptides are... Agent: Bozicevic, Field & Francis LLP

20070042390 - Method and device for critical dimension detection by molecular binding: Critical Dimension (CD) of features on a semiconductor substrate may be indicated utilizing the site-specific binding properties of organic or biological molecules. In accordance with one embodiment of the present invention, a fluorescent tagged organic molecule is fabricated having a length corresponding to the desired CD. The semiconductor substrate is... Agent: Townsend And Townsend And Crew, LLP

20070042389 - Method and sequences for determinate nucleic acid hybridization: Provided are methods for using nucleic acid sequences having two or more degenerately pairing nucleotides, each degenerate nucleotide having a partially overlapping set of complementarity, to reduce the number of hybridizing nucleotide sequences or probes used in biochemical and molecular biological operations having sequence specific hybridization. The method may be... Agent: Searete LLC

20070042372 - Method for designing dna codes used as information carrier: The present invention provides a method for designing DNA code consisting of a set of information codes as an information carrier to write optional information into an optional noncoding region not including any DNA genetic information which can avoid an error occurring when the designed DNA is used. A set... Agent: Alston & Bird LLP

20070042384 - Method for isolating and modifying dna from blood and body fluids: This invention is related a method for rapidly isolating and modifying DNA from plasma/serum and body fluids. This invention provides a procedure and composition to obtain a high yield of modified DNA for methylation-specific PCR assay by coupling DNA isolation and modification courses.... Agent: Jessica M. Li

20070042402 - Method for predicting human longevity: The present disclosure concerns methods of detecting levels of one or more molecules(s), longevity predicting marker(s), in a sample, and using these levels of the marker(s) to predict a condition. In a particular embodiment, the present invention concerns methods of detecting longevity predicting marker(s), in a sample, preferably to assess... Agent: Faegre & Benson LLP Patent Docketing

20070042421 - Method of identifying nucleic acids: Disclosed are methods for identifying nucleic acids in a sample of nucleic acids in which nucleic acids are initially present in unequal amounts. The methods include partitioning the starting population of nucleic acids to form one or more subpopulations, and then identifying nucleic acids that are present in different amounts... Agent: Curagen Corporation

20070042388 - Method of probe design and/or of nucleic acids detection: It is provided a method of designing oligonucleotide probe(s) for nucleic acid detection comprising the following steps in any order: (i) identifying and selecting region(s) of a target nucleic acid to be amplified, the region(s) having an efficiency of amplification (AE) higher than the average AE; and (ii) designing oligonucleotide... Agent: Dickstein Shapiro LLP

20070042362 - Methods and apparatus for use in genetics classification including classification tree analysis: Methods and apparatus for use in genetic trait classification involving at least two genes associated with a genetic trait are described. In one illustrative method, a value for use in classifying an individual into one of a plurality of trait classes associated with the genetic trait is calculated. The value... Agent: John J. Oskorep, Esq. One Magnificent Mile Center

20070042401 - Methods for synthesis of encoded libraries: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.... Agent: Lahive & Cockfield, LLP

20070042360 - Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer: Described herein are genes whose expression are up-regulated or down-regulated in specific cancers. Related methods and compositions that can be used for diagnosis and treatment of those cancers are disclosed. Also described herein are methods that can be used to identify modulators of selected cancers.... Agent: Howrey LLP

20070042400 - Methods of preparing nucleic acid for detection: Methods of preparing nucleic acid from polysaccharide-containing samples for detection by providing one or more glycosidases to the sample to degrade polysaccharides are provided. The nucleic acids can further be extracted from the sample. The method is particularly useful for detecting nucleic acid in samples with high starch content.... Agent: Brinks Hofer Gilson & Lione

20070042369 - Methods of selection, reporting and analysis of genetic markers using borad-based genetic profiling applications: Disclosed are a method for determining whether an individual has an enhanced, diminished, or average probability of exhibiting one or more phenotypic attributes and related methods of selecting a set of genetic markers; for providing relevant genetic information to an individual; of evaluating the probability that progeny of two individuals... Agent: Sidley Austin LLP Attn: Dc Patent Docketing

20070042417 - Methods of using zven polynucleotides: The present invention provides novel uses two members of a new family of human proteins, designated as “Zven,” as agents that stimulate gastrointestinal contractility, gastric emptying, intestinal transit, and treating gastroparesis The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes. The... Agent: Zymogenetics, Inc. Intellectual Property Department

20070042376 - Mn/ca ix and cancer prognosis: Herein disclosed are methods that are prognostic for neoplastic/preneoplastic disease in a subject vertebrate, wherein said disease is associated with a tissue that normally expresses MN, but which MN expression is lost or diminished upon carcinogenesis. Exemplary of the types of preneoplastic/neoplastic diseases subject to the prognostic methods of this... Agent: Leona L Lauder Attorney At Law

20070042379 - Modified dna cleavage enzymes and methods for use (as amended by isa): Compositions and methods are provided that relate to a modified DNA cleaving enzyme having at least 35% amino acid sequence identity with T7 Endo I. The modified enzyme includes two catalytic centers separated by a β-bridge where the β-bridge contains at least one mutation having an effect of altering enzyme... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20070042407 - Modified nucleosides and nucleotides and uses thereof: The invention is directed to modified guanine-containing nucleosides and nucleotides and uses thereof. More specifically, the invention relates to modified fluorescently labelled guanine-containing nucleosides and nucleotides which exhibit enhanced fluorophore intensity by virtue of reduced quenching effects.... Agent: Klauber & Jackson

20070042371 - Mptens as modifers of the pten/igf pathway and methods of use: Human MPTEN genes are identified as modulators of the PTEN/IGF pathway, and thus are therapeutic targets for disorders associated with defective PTEN/IGF function. Methods for identifying modulators of PTEN/IGF, comprising screening for agents that modulate the activity of MPTEN are provided.... Agent: Mcdonnell Boehnen Hulbert @ Berghoff LLP

20070042411 - Multiplexed pcr assay for detection of bovine spongiform encephalopathy (bse)-associated bovine prion protein gene (prnp) polymorphisms: A multiplexed PCR assay system and method are provided for detection of bovine prion protein gene (PRNP) insertion/deletion polymorphisms that are associated with bovine spongiform encephalopathy (BSE), thereby identifying a population of cattle or individual therefrom that possesses an elevated level of putative resistance or susceptibility to BSE. Such system... Agent: Howrey LLP

20070042383 - Mycobacterial diagnostics: The present invention provides nucleic acid molecules unique to M. paratuberculosis. The invention also provides the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules of the invention, and antibodies having specific binding affinity for the polypeptides encoded by the M. paratuberculosis-specific nucleic acid molecules. The invention further provides for... Agent: Fish & Richardson P.C.

20070042366 - Nanopores, methods for using same, methods for making same and methods for characterizing biomolecules using same: Featured are devices and systems embodying one or more solid-state nanopores useable for sensing and/or characterizing single macromolecules as well as sequencing DNA or RNA and/or determining RNA secondary structures. In once solid state nanopore of the present invention the width and/or length of the nanopore is defined or established... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20070042385 - Novel compositions and methods in cancer: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that present novel therapeutic targets against cancer. The present invention... Agent: Gwilym Attwell (cozen O'connor)

20070042392 - Novel nucleic acids and polypeptides: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.... Agent: Nuvelo, Inc

20070042363 - Novel polypeptide and nucleic acid encoding the same: A novel protein which binds with tumor necrosis factor receptor associated factor 2, TRAF2, as well as a nucleic acid coding for the protein is disclosed. From a mouse cDNA library, a cDNA coding for a novel protein which binds with TRAF2 was discovered by mammalian two-hybrid assay, the cDNA... Agent: Birch Stewart Kolasch & Birch

20070042374 - Novel protein: The present invention provides a protein containing the same or substantially the same amino acid sequence as the amino acid sequence starting at Amino Acid No. 1 in the amino acid sequence shown by SEQ ID NO:2 or 4, the nucleic acid that encodes it, a method of screening a... Agent: Edwards & Angell, LLP

20070042391 - Nucleic acid and amino acid sequences relating to staphylococcus epidermidis for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Drinker Biddle & Reath (dc)

20070042396 - Nucleic acid purification apparatus including photovoltaic device, microfluidic apparatus including the nucleic acid purification apparatus, and method of purifying nucleic acid using the nucleic acid purification apparatus: Provided are a nucleic acid purification apparatus including a chamber that includes an inlet and an outlet, at least two electrodes that defines the chamber and form an electric field, a photovoltaic device that applies a bias to the electrodes, a microfluidic apparatus including the same, and a method of... Agent: Cantor Colburn, LLP

20070042408 - Nucleotide sequence for assessing transmissible spongiform encephalopathies: The present invention is directed to the assessment of transmissible spongiform encephalopathy (TSE) using a sample from a living individual. The assessment is based on the use of an RNA marker molecule in a sample of whole blood. The RNA encodes a hypothetical cystein protease. The invention is further directed... Agent: Roche Diagnostics Operations Inc.

20070042422 - Oligonucleotides for rapidly identifying microbial dna or rna: An oligonucoeotide selected from the group consisting of ISN2 (SEQ ID NO: 43), ISN2* (SEQ ID NO: 44), ISN (SEQ ID NO: 34), ISP2 (SEQ ID NO: 46), ISP2* (SEQ ID NO: 45) and ISP (SEQ ID NO: 33).... Agent: Frishauf, Holtz, Goodman & Chick, PC

20070042413 - Platelet-derived growth factor d, dna coding therefor, and uses thereof: PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in... Agent: Crowell & Moring LLP Intellectual Property Group

20070042387 - Promoter, promoter control elements, and combinations, and uses thereof: The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels.... Agent: Birch Stewart Kolasch & Birch

20070042373 - Protein identification methods and systems: The present invention relates to methods and systems for identifying proteins. In particular the invention provides a method for identifying a protein through amino acid sequences of one or more query peptides generated from the protein. The method involves translating amino acid sequences of the query peptides to all possible... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20070042378 - Regulation of prokaryotic gene expression with zinc finger proteins: Chimeric zinc finger proteins, and methods of using zinc finger proteins for regulating gene expression in prokaryotes are disclosed herein.... Agent: Sughrue Mion, PLLC

20070042414 - Retentate chromatography and protein chip arrays with applications in biology and medicine: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical... Agent: Townsend And Townsend And Crew LLP

20070042410 - Screening method for genes of brewing yeast: Provided herein are a method for selecting a gene participating in the desired brewing character and compiling a database of the whole genome sequence of industrial yeast; identifying a gene participating in a brewing characteristic from the database; functional analysis of the gene; and a DNA array of the whole... Agent: Drinker Biddle & Reath (dc)

20070042403 - Specific inhibitors of nfat activation by calcineurin and their use in treating immune-related diseases: Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein-protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions... Agent: Fish & Richardson PC

20070042364 - Target genes for inflammatory bowel disease: Two genes have been discovered that show single nucleotide polymorphisms that are differentially expressed in patients with inflammatory bowel disease (IBD) as compared to unaffected controls. These two genes, FLJ21425 and CSF1R (colony stimulating factor 1 receptor), are located close together on chromosome 5q33 which was known to have other... Agent: Patent Department Taylor, Porter, Brooks & Phillips, L.l.p

20070042397 - Techniques for linking non-coding and gene-coding deoxyribonucleic acid sequences and applications thereof: Techniques for linking non-coding and gene coding regions of a genome are provided. In one aspect, a method of determining associations between non-coding sequences and gene coding sequences in a genome of an organism comprises the following steps. At least one conserved region is identified from one or more non-coding... Agent: Ryan, Mason & Lewis, LLP

20070042418 - Therapeutic modulation of the fas pathway: A method for the identification of genes that are essential for the maintenance of specific cell phenotypes is disclosed. The method includes the initial step of identifying a cell type with a phenotype of interest. Gene inactivation is performed on an aliquot of cells of the cell type of interest.... Agent: Cooper & Dunham, LLP

20070042430 - Apparatus and method for single-step immunosorbent assay for single and multiple analytes: The present invention discloses an apparatus and method for minimizing or eliminating steps in immunosorbent assays by eliminating both the need to attach target molecules to the test well and the need to remove unbound antibodies through rinsing. The single-step immunosorbent assay (SISA) includes the step of mixing the immunologic... Agent: Kammer Browning PLLC

20070042429 - Assay for differentiating alzheimer's and alzheimer's-like disorders: The invention relates to an assay for discriminating between Alzheimer's disease (AD) patients, patients with AD-Like disorders that express symptoms like AD, and non-demented age-matched controls (Normal). The method is based on the use of 2-dimensional (2D) gel electrophoresis to separate the complex mixture of proteins found in blood serum,... Agent: Power3 Medical Products, Inc.

20070042426 - Biomarkers and assays for myocardial infarction: Presented herein are novel blood plasma/serum biomarkers related to cardiovascular disease. These newly identified biomarkers create the basis for multiple (single) assays using traditional bioassay technologies and when used in combination yield exceptional clinical sensitivity and specificity in the determination of myocardial infarction (MI). A multiplexed, mass spectrometric immunoassay (MSIA)... Agent: Snell & Wilmer

20070042425 - Diagnostic method for brain damage-related disorders: A brain damage-related disorder is diagnosed in a subject by detecting at least one polypeptide, or a variant or mutant thereof, selected from A-FABP, E-FABP, PGP 9.5, GFAP, Prostaglandin D synthase, Neuromodulin, Neurofilament L, Calcyphosine, RNA binding regulatory subunit, Ubiquitin fusion degradation protein 1 homolog, Nucleoside diphosphate kinase A, Glutathione... Agent: Arent Fox PLLC

20070042423 - Diagnostics and therapeutics for diseases associated with arginyl aminopeptidase rnpep-like (rnpep-like): The invention provides a human RNPEP-like which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological... Agent: Banner & Witcoff

20070042424 - Method of selectively assaying adiponectin multimers: We have discovered a “human adiponectin ELISA kit”, which can specifically measure adiponectin in human blood serum (or blood plasma) or in extracted fluid from lipocytes or culture supernatant fluid. After fractioning human serum by use of gel filtration column, each fraction was measured by the present kit, and as... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070042431 - Methods for reducing complexity of a sample using small epitope antibodies: The present invention relates generally to methods for reducing the complexity of a sample. More specifically, the present invention relates to proteomics, the measurement of the protein levels in biological samples, and analysis of proteins in a sample using antibodies that recognize small epitopes.... Agent: Morrison & Foerster LLP

20070042427 - Microfluidic laminar flow detection strip: The present invention relates to microfluidic laminar flow detection strip devices and methods for using and making the same. The disclosed devices comprise: a first inlet; a microfluidic channel having a first end and a second end, wherein the first end is fluidly connected to the first inlet; a bellows... Agent: Seed Intellectual Property Law Group PLLC

20070042428 - Treatment of proliferative disorders: Inhibitors of cIAP-1 and methods and compositions for treating proliferative disorders.... Agent: Pepper Hamilton LLP

20070042435 - Assays for sensory modulators using a sensory cell specific g-protein beta subunit: The invention identifies nucleic acid and amino acid sequences of sensory specific G-protein beta subunits that are specifically expressed in sensory cells, antibodies to such subunits, methods of detecting such nucleic acids and proteins, and methods of screening for modulators of sensory cell specific beta subunits.... Agent: Townsend And Townsend And Crew, LLP

20070042436 - Cd38 modulated chemotaxis: The present invention relates to methods for modulating the migratory activity of cells expressing CD38 for the treatment of disorders including, but not limited to, inflammation, ischemia, asthma, autoimmune disease, diabetes, arthritis, allergies, infection with pathogenic organisms, such as parasites, and transplant rejection. Such cells include, for example, neutrophils, lymphocytes,... Agent: Kenyon & Kenyon LLP

20070042437 - Diagnosis and treatment of alzheimer's disease: This invention relates to methods for diagnosing Alzheimer's Disease (AD) by determining the level or function of insulin, insulin-like growth factors, their receptors and/or their downstream signaling molecules. The invention further relates to methods for the treatment of AD by administering an insulin agonist and an insulin-like growth factor agonist.... Agent: Sterne, Kessler, Goldstein & Fox PLLC

20070042434 - Method for identifying tff2 regulating agents and agents identified using said method: Agents useful for modulating the dioxin/aryl hydrocarbon receptor (AhR) can now be identified by determining the binding to said receptor and whether said agent suppresses or inhibits the expression of a gene substantially consisting of a sequence according to one of SEQ.ID. NO. 1 and SEQ.ID. NO. 2; a nucleotide... Agent: Morrison & Foerster LLP

20070042432 - Method of diagnosis and treatment: The present invention relates generally to a method for detecting an aberrant cell, and more particularly an apoptotic cell, in a subject or in a biological sample from said subject, and agents useful for same. The presence of the aberrant cell or group of aberrant cells provides an indication of... Agent: Seed Intellectual Property Law Group PLLC

20070042433 - Neuregulin protein regulation of synaptic proteins: e

20070042443 - Hematopoietic cell phenotyping using free circulating cellular markers: The present invention provides methods of identifying cluster of differentiation (CD) marker phenotype for hematopoietic cells using multiple soluble CD markers circulating in bodily fluid. In particular aspects, the CD marker phenotype can be used to classify the tumor type of a patient having a proliferative disorder. In other aspects,... Agent: Foley & Lardner LLP

20070042446 - Mammalian iap gene family, primers, probes and detection methods: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primer and probes for the identification and isolation of additional IAP genes.... Agent: Philip Swain, Phd C/o Gowling Lafleur Henderson

20070042445 - Method for demonstration of a molecular event in a cell by means of fluorescent marker proteins: The invention relates to a method for demonstration of the occurrence of a molecular event, particularly in a cell, characterised by the detection of the “solubilisation” of a fixed protein marker (or the fixing of a solubilised protein marker) which is a direct or indirect marker for the occurrence of... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20070042444 - Multiple-channel test device, method for producing the same and use thereof: The object of the invention is a multiple-channel test devise based on immunodiffusion and immunochromatography, which enables the simultaneous or parallel determination of several analytes. In the test devise, it is possible to group together different combinations of markers recognizing allergens, myocardial infarction markers, venereal disease analytes, blood screening analytes,... Agent: Foley & Lardner LLP

20070042447 - Use of anti-ferritin monoclonal antibodies in the treatment of some cancers (divisional): The invention concerns the use, in the preparation of a medicine for treating cancer whereof the cells exhibit overexpression of a product of a gene of the myc-related family, of an anti-ferritin monoclonal antibody or a fragment thereof, said antibody or said fragment identifying an epitope common to acidic and... Agent: Merchant & Gould PC

20070042448 - Use of enzymes from helicobacter pylori as therapeutical targets: Methods for identifying molecules which inhibit the virulence or pathogenicity of Helicobacter pylori by modulating the activity of hydrolases encoded by genes amiA, mltD and slt. Compositions and diagnostic and treatment methods using hydrolases and molecules which inhibit them.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070042440 - Biosensor for analyzing quantitatively analyte with a predetermined size and larger than, and manufacturing method thereof: The present invention discloses a biosensor for quantitatively analyzing a bio-material and a manufacturing method thereof. The biosensor has an exposed conductive region of a few-nanometer scale distributed on an insulated metallic substrate in a desired pattern or randomly. The quantitative analysis of protein can be carried out by means... Agent: Macpherson Kwok Chen & Heid LLP

20070042441 - Method and apparatus for detecting estradiol and metabolites thereof using an acoustic device: Methods for detecting estradiol and metabolites thereof in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for estradiol, is combined with the sample to form a plurality of estradiol-particle complexes. The system also includes a transport arrangement for... Agent: Proskauer Rose LLP

20070042439 - Porphyrin compound containing biotinyl group and use thereof: wherein Por represents a porphyrin residue optionally forming a metal complex; Bi represents an optionally substituted biotinyl group; and A represents a C1-C20 hydrocarbyl group, or a heterohydrocarbyl group having 1-5 heteroatoms selected from a group consisting of oxygen, sulfur, and nitrogen, and having 1-20 atoms in total; a method... Agent: Foley And Lardner LLP Suite 500

20070042442 - Protein microarrays on mirrored surfaces for performing proteomic analyses: Provided are protein microarrays, their manufacture, use, and application. Protein microarrays in accordance with the present invention are useful in a variety preoteomic analyses. Various protein arrays in accordance with the present invention may immobilize large arrays of proteins that may be useful for studying protein-protein interactions to improve understanding... Agent: Novartis Vaccines And Diagnostics Inc.

20070042438 - Scd4ol and placental growth factor (plgf) used as a biochemical marker combination in cardiovascular diseases: The invention relates to novel markers of vascular inflammation and combinations thereof as diagnostic and prognostic tools in patients with cardiovascular diseases. The markers also act as tools that facilitate the selection of active ingredients for the treatment of such diseases, and finally act as starting points for the treatment... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070042449 - Method of detection in homogeneous phase, especially of progesterone in mammals' milk, and corresponding kit: Method for the qualitative and semi-quantitative detection of a ligand in a sample of a medium to be tested, by (1) diluting at least one lyophilised reaction medium in said sample, (2) incubating the sample in order to carry out an immunoenzymatic method, and (3) observing the resulting colouration.... Agent: Jacobson Holman PLLC

20070042450 - Multi-transduction mechanism based microfluidic analyte sensors: In various aspects are provided a microfluidic and/or nanofluidic sensor that can provide an indication of the reliability of its measurement of the presence of an analyte in a sample under investigation, an analyte concentration in the sample under investigation, or both. The provided sensors, microfluidic devices, and methods of... Agent: Lahive & Cockfield, LLP

20070042451 - Glycine decarboxylase complex as a herbicidal target: The invention relates to the use of glycine decarboxylase complex, which is used as a target for herbicides in the absence of growth retardations and chlorotic leaves. Novel nucleic acid sequences comprising SEQ ID NO:1 and functional equivalents of SEQ ID NO:1 are thus disclosed. The invention also relates to... Agent: Connolly Bove Lodge & Hutz, LLP

20070042452 - Detection of plasma ace2: A method of assessing a subject for aberrant cardiac function is described. The method particularly involves the measurement of a plasma biomarker, namely metallopeptidase angiotensin-converting enzyme 2 (ACE2), implicated in ischaemic heart disease.... Agent: Sheridan Ross PC

20070042453 - High throughput screening method for antimicrobial formulations: Methods and systems are provided for increasing the speed and throughput at which the antimicrobial effects of chemical formulations can be evaluated. Generally, the invention provides a method for screening antimicrobial chemical formulations, comprising depositing microorganisms on a slide, depositing chemical formulations onto the deposited microorganisms, removing the chemical formulations... Agent: Linda K. Russell

20070042454 - Device and method of detecting streptococcal mutans: A device, kit and method for detecting oral bacteria are provided. The device is a tube, which includes on its inside surface a coating of an agar medium selective for growing gram-positive bacteria. The device is particularly suitable for detecting the extent of growth of mutans streptococci, which provides an... Agent: Hoffmann & Baron, LLP

20070042456 - Porous ceramic, polymer and metal materials with pores created by biological fermentation: Porous polymers are made by adding biologically active agent and growth substrates (e.g., yeast and sugar, preferably in the presence of water or other suitable fluid) to a polymer forming material, which may be a liquid. The yeast acts on the sugar, forming carbon dioxide gas bubbles. The material is... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070042455 - Porous ceramic, polymer and metal materials with pores created by biological fermentation: Porous polymers are made by adding biologically active agent and growth substrates (e.g., yeast and sugar, preferably in the presence of water or other suitable fluid) to a polymer forming material, which may be a liquid. The yeast acts on the sugar, forming carbon dioxide gas bubbles. The material is... Agent: Whitham, Curtis & Christofferson & Cook, P.C.

20070042457 - Process for producing penicillin: The invention relates to isolated nucleic acid molecules, which code for a new protein of Penicillium chrysogenum, vectors which comprise a nucleic acid molecule of this kind, host cells which are transformed with such a nucleic acid molecule or vector, and a process for the production of penicillin using such... Agent: Novartis Corporate Intellectual Property

20070042459 - Dipeptide production method, l-amino acid amide hydrolase used therein, and production method of l-amino acid amide hydrolase: A process for industrially advantageously producing a dipeptide via a convenient pathway starting with less expensive and easily available materials is provided. A dipeptide is produced from an L-amino acid amide and an L-amino acid by using a culture of a microbe capable of synthesizing the dipeptide from the L-amino... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070042458 - Erythropoietin: remodeling and glycoconjugation of erythropoietin: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.... Agent: Morgan, Lewis & Bockius LLP (sf)

20070042461 - Compositions of orthogonal lysyl-trna and aminoacyl-trna synthetase pairs and uses thereof: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing... Agent: Quine Intellectual Property Law Group, P.C.

20070042464 - Hybrid vector having a cytomegalovirus enhancer and myeloproliferative sarcoma virus promoter: An expression vector capable of expressing high levels of heterologous proteins having a cytomegalovirus (CMV) enhancer 5′ upstream from a myeloproliferative sarcoma virus (MPSV) promoter.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070042466 - Il-1 related polypeptides: The present invention is directed to novel polypeptides having homology to the IL-1-like family of proteins and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous... Agent: Genentech, Inc.

20070042465 - Mammalian transforming growth factor beta-9: Novel mammalian Ztgfβ-9 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070042467 - Nima interacting proteins: A novel class of NIMA interacting proteins (PIN), exemplified by Pin1, is provided. Pin1 induces a G2 arrest and delays NIMA-induced mitosis when overexpressed, and triggers mitotic arrest and DNA fragmentation when depleted. Methods of identifying other Pin proteins and Pin-interacting proteins and identifying compositions which affect Pin activity or... Agent: Klarquist Sparkman, LLP

20070042463 - Nucleic acid encoding proteins involved in protein degradation, products and methods related thereof: In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or... Agent: Biotechnology Law Group C/o Portfolioip

20070042460 - Oxidation of peptides: The folding/oxidation of a reduced peptide or partially reduced peptide to form a disulphide bridged peptide is effected by dissolving it in an oxidizing organic solvent, alone or in admixture with water, adding an aqueous alkaline buffer to the solution, and recovering the resultant disulphide bridged peptide. The preferred oxidizing... Agent: Darby & Darby P.C.

20070042462 - Super-size adeno-associated viral vector harboring a recombinant genome larger than 5.7 kb: Prior art teaches an effective packaging capacity for adeno-associated virus and adeno-associated viral vectors of 4.1 kb to 4.9 kb as well as a packaging limit of 5.2 kb to 5.6 kb. However, the inventor discovered that this packaging limit as well as that effective packaging capacity does not apply... Agent: Markus Hildinger

20070042470 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070042471 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070042469 - Homogeneous preparations of il-28 and il-29: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity... Agent: Zymogenetics, Inc. Intellectual Property Department

20070042468 - Interferon-like protein zcyto21: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070042472 - Mammalian transforming growth factor beta-9: Novel mammalian Ztgfβ-9 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.... Agent: Zymogenetics, Inc. Intellectual Property Department

20070042473 - Method for preparing a fluid absorber: Disclosed are a fluid absorber, a method for preparing a fluid absorber, and a method for absorbing fluid from the skin. The disclosed method for preparing a fluid absorber generally comprises the steps of selecting a starch and an enzyme for hydrolysis of the starch, determining a fluid absorption optimum... Agent: Banner & Witcoff, Ltd.

20070042474 - Corynebacterium glutamicum genes encoding novel proteins: Isolated nucleic acid molecules, designated MCP nucleic acid molecules, which encode novel MCP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP.

20070042475 - Method for the enzymatic production of chiral 1-acylated 1,2-diols: o

20070042476 - Novel gene encoding malic enzyme and method for preparing succinic acid using the same: A nucleotide sequence encoding a malic enzyme and a method for preparing succinic acid using the same, more particularly, a maeB nucleotide sequence encoding a malic enzyme B having the activity of converting pyruvic acid or pyruvate to malic acid or malate, or vice versa, a recombinant vector containing the... Agent: Intellectual Property / Technology Law

20070042477 - Novel gene encoding fumarate hydratase c and method for preparing succinic acid using the same: A nucleotide sequence encoding a fumarate hydratase C and a method for preparing succinic acid using the same, more particularly, a fumarate hydratase C having the activity of converting malate to fumarate, a fumC nucleotide sequence encoding the fumarate hydratase C, a recombinant vector containing the nucleotide sequence, a microorganism... Agent: Intellectual Property / Technology Law

20070042478 - Fermentation of monovalent secondary alcohols in order to form corresponding ketones: The present invention concerns a fermentation process for converting a monohydric secondary alcohol having 5 or more carbon atoms into the corresponding ketone, suitable microorganisms for that purpose.... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20070042479 - Conversion of carbon dioxide to methanol in silica sol-gel matrix: In a sequential enzymatic reduction of carbon dioxide to methanol in which electrons are supplied by conversion of NADH to NAD+, NADH may be regenerated from the NAD+ by conversion of lactate to pyruvate by lactate dehydrogenase enzymes.... Agent: Thompson Coburn, LLP

20070042481 - Novel gene encoding formate dehydrogenases d & e and method for preparing succinic acid using the same: Nucleotide sequences encoding formate dehydrogenases D & E and a method for preparing succinic acid using the same, more particularly, formate dehydrogenases D & E converting formate to carbon dioxide and hydrogen, fdhD and fdhE nucleotide sequences encoding the formate dehydrogenases D & E, recombinant vectors containing the nucleotide sequences,... Agent: Intellectual Property / Technology Law

20070042480 - Process for producing hydrogen: A process for producing hydrogen from bio-oxidisable material is disclosed herein. The process comprises the steps of—introducing the bio-oxidisable material into a reactor provided with an anode and a cathode optionally separated by a cation exchange membrane and containing anodophilic bacteria in an aqueous medium;—applying a potential between the anode... Agent: Christine A Lekutis Medlen & Carroll

20070042482 - Sulfur-oxidizing bacteria and their use in bioleaching processes for sulfured copper minerals: The present invention is related to an isolated chemolithotrophic bacterium belonging to species Acidithiobacillus thiooxidans named Licanantay, deposited in Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH-DSMZ with number DSM 17318, and its use in pure form or in mixtures that contains it for bioleaching processes of minerals or sulfured metallic... Agent: Merchant & Gould PC

20070042483 - Methods and device for adhesive control of internal cell organisation: The present invention relates to methods and devices for adhering cells in a specific and predetermined position with an adhesive control of internal cell organisation, methods for preparing such devices, methods for studying modifications of cell shape and global internal cell organization such as the distribution of cellular compartments, centrosome... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070042484 - Method to remove bisulfite by-products from enzyme compositions: Provided are methods of removing bisulfite material from a composition that contains a bisulfite material and an enzyme. The method includes contacting the composition with a compound containing at least one aldehyde functional group to form an aldehyde-bisulfite complex, whereby the aldehyde-bisulfite complex may be separated from the composition.... Agent: Colgate-palmolive Company

20070042485 - Modified trap protein for producing nano-scale electrical devices, and a method for producing such a protein: The present invention provides a modified TRAP protein formed from a plurality of genetically engineered fusion molecules of TRAP monomers, wherein said fusion molecule consists of two, three or four wild type TRAP monomer equivalents.... Agent: Foley And Lardner LLP Suite 500

20070042486 - Stablized actively aerated compost tea: In combination, an aerobic microbial biomass and viability supporting container therefore. The aerobic microbial biomass is composed of microorganisms extracted from a tea composition and stored as a liquid or applied to a stabilizing medium for storage as a solid. The aerobic microbial biomass is stored in a container which... Agent: Dergosits & Noah LLP Suite 1450

20070042487 - Bioreactor valve island: A bioreactor valve island is provided according to an embodiment of the invention. The bioreactor valve island includes a sparge mixing region that receives and mixes a first air input and one or more first gas inputs and an overlay mixing region that receives and mixes a second air input... Agent: The Ollila Law Group LLC

20070042488 - Cell spraying device, method and sprayed cell suspension: The invention provides a device and methods suitable for producing a cellular spray of cells. The sprayed cells are of interest for covering and growing on a surface, including a skin wound. In applying the method and/or using the device, cells for grafting onto a patient are dispersed in a... Agent: Jorg C. Gerlach

20070042489 - Self-contained assay device for rapid detection of biohazardous agents: The invention relates to self-contained assay cassette for detecting a ligand in a sample. The assay cassette provides for turbulent flow and mixing of the sample with assay components, including receptors that bind to a ligand, optional microspheres capable of binding the receptors or to which other secondary receptors are... Agent: Calfee Halter & Griswold, LLP

20070042490 - Apparatus and method for tissue engineering: A bioreactor system includes a housing and a hydrostatic loading module. The housing includes a chamber with an inlet port and an outlet port. The inlet and outlet ports allowing the chamber to be continuously perfused with a culture medium while chamber is hydrostatically loaded.... Agent: Richard A. Sutkus Tarolli, Sundheim, Covell & Tummino

20070042491 - Amplification of cell populations from embryonic stem cells: Culturing embryonic stem cells without the use of embryoid bodies leads to a increase in the frequency of predetermined cell types.... Agent: Choate, Hall & Stewart LLP

20070042492 - Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei: The present invention relates to an amino acid sequence being able to facilitate penetration of a substance of interest inside cells and/or cell nuclei and having the following formula (I) [(X1)p [(X)o (B)nX B X X B]m (X2)q Wherein X1 and X2 are amino acid sequences of 1 to 20... Agent: Hunton & Williams LLP Intellectual Property Department

20070042493 - Method and process of genetic transformation using supercritical fluids: Methods are provided for improving the ability of non-naturally transformable cells to take up and integrate DNA. Generally, the invention provides a method for transforming cells, comprising combining deoxyribonucleic acid (DNA) and a recipient cell culture for the uptake of the DNA, placing mixture of recipient cell culture and DNA... Agent: Linda K. Russell

20070042494 - Heterologous retroviral packaging system: A chimeric retroviral vector comprising sequences from at least two retroviruses, wherein at least one of the sequences encodes a cis element, and wherein the chimeric retroviral vector is capable of being packaged in a viral particle; and methods of making and using the same.... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.

20070037132 - Separation of platelets from fluid suspensions: A device for separating platelets from a fluid suspension comprises a mixing chamber operable to receive and mix fluid suspensions and an aggregating agent to form platelet aggregates and residual fluid components. A filter can be configured to be in fluid communication with the mixing chamber and can be further... Agent: Thorpe North & Western, LLP.

20070037134 - Functional coupling of t1rs and t2rs by gi proteins, and cell-based assays for the identification of t1r and t2r modulators: The invention resides in part in the discovery that G proteins other than Gα15 couples to T1R and T2R taste receptors, particularly Gi proteins such as Gαi. Related to this discovery, the invention provides cell-based assay methods for identifying compounds that modulate the activity of specific T1R or T2R taste... Agent: Hunton & Williams LLP Intellectual Property Department

20070037133 - Method and apparatus for use of thermally switching proteins in sensing and detecting devices: An apparatus and method for detecting infrared radiation is provided which comprises a temperature-sensing helical coiled-coil protein such as TIpA, CC1, collagen or myosin, incorporated into an electrically conductive film or gel deposited onto an electrically conductive medium such as an electrode, means for recording changes in conductivity or resistance... Agent: Stites & Harbison PLLC

20070037136 - Method of preparing cell cultures from biological specimens for assaying a response to an agent: An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying. One particularly... Agent: Cooley Godward Kronish LLP

20070037135 - System and method for the identification and quantification of a biological sample suspended in a liquid: A system for the identification and quantification of a biological sample suspended in a liquid includes a fluorescence excitation module with at least one excitation light source; a sample interface module optically coupled to the fluorescence excitation module for positioning a biological sample to receive excitation light from the at... Agent: The Webb Law Firm, P.C.

20070037137 - Method and kit for quantitative and qualitative determination of human papillomavirus: The present invention relates to a method and kit for quantitative and qualitative determination of human papillomavirus, HPV, in a sample. More precisely, for quantitative and qualitative determination of oncogenic HPV to predict the risk of HPV infection resulting in cervical carcinoma. The method and kit enable simultaneous measurement of... Agent: Dinsmore & Shohl, LLP

20070037143 - Method for screening for protease modulators: The present invention is in the field of pharmaceutical research tools. Specifically, the present invention provides methods for screening compounds or compositions with respect to their ability and/or specificity to modulate the activity of proteases.... Agent: Edwards & Angell, LLP

20070037139 - Method of analyzing gene introduction site: A method of analyzing, in chromosomal DNA having a retroviral vector incorporated therein, DNA region derived from chromosome which is adjacent to the vector, characterized in that a primer extension reaction and a nucleic acid amplification reaction are carried out in the presence of a compound capable of lowering the... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20070037142 - Methods and apparatus for detecting viruses using an acoustic device: Methods for detecting viruses are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the virus, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the... Agent: Proskauer Rose LLP

20070037140 - Methods and compositions for detecting sars virus: This invention relates generally to the field of virus detection. In particular, the invention provides chips, probes, primers, kits and methods for amplifying and detecting SARS-CoV nucleotide sequence. The clinical and other uses of the present chips, probes, primers, kits and methods are also contemplated.... Agent: Morrison & Foerster LLP

20070037141 - Methods and compositions for inhibition of membrane fusion-associated events, including hiv transmission: The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides... Agent: Jones Day

20070037138 - Standard for immunohistochemistry, immunocytochemistry and molecular cytogenetics: This application describes a method comprising: (a) providing a reference standard or a planar section thereof, the reference standard comprising (i) a support medium; and (ii) a quantity of a detectable entity supported by the support medium; in which the detectable entity has an elongate path; in which a predetermined... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070037194 - Allelic variation in the serotonin transporter (sert) as an indicator of autism: The present invention describes allelic variations in the SERT gene that are linked with the development of autism.... Agent: Fulbright & Jaworski L.L.P.

20070037191 - Apo-2dcr: Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.... Agent: Genentech, Inc.

20070037171 - Aptamer-based colorimetric sensor systems: The present invention provides an aptamer-based calorimetric sensor system for determining the presence and optionally the concentration of an analyte in a sample. Methods of utilizing the sensor system and kits that include the sensor also are provided. The sensor utilizes a linker and oligonucleotide functionalized particles to form an... Agent: Evan Law Group LLC

20070037146 - Biodisc microarray and its fabrication, use, and scanning: A biodisc comprises a CD-type optical disc with small feature oligonucleotide probes disposed on its surfaces. The biodisc's probes are either custom-fabricated in-situ with a master-duplicate tandem arrangement of discs that allows one disc and a reading/tracking head to control the probe locations being synthesized pass-by-pass on the duplicate. Or... Agent: Vierra Magen Marcus & Deniro LLP

20070037151 - Cd4+ human papillomavirus (hpv) epitopes: The present invention provides CD4+ T-cell epitopes in E6, E7 and E2 proteins from various strains of human papillomavirus (HPV). In some preferred embodiments, the present invention provides means for the development of HPV vaccines, in particular multivalent vaccines for the prevention of infection with high-risk HPV strains. In additional... Agent: Genencor International, Inc. Attention: Legal Department

20070037174 - Chemiluminescent generated fluorescent labeling: A method for detecting a target analyte in a sample having the steps of: binding the target analyte to a solid substrate; binding a reporter to the bound target to form a label enzyme; contacting a chemiluminescent reagent with the label enzyme to produce a fluorescent precipitate; and detecting fluorescence... Agent: Beckman Coulter Inc. C/o Sheldon Mak Rose & Anderson

20070037173 - Circulating tumor cells (ctc's): early assessment of time to progression, survival and response to therapy in metastatic cancer patients: A cancer test having prognostic utility in predicting time to disease progression, overall survival, and response to therapy in patients with MBC based upon the presence and number of CTC's. The Cell Spotter® System is used to enumerate CTC's in blood. The system immunomagnetically concentrates epithelial cells, fluorescently labels the... Agent: Immunicon Corporation

20070037181 - Compositions and methods for detecting pathogen specific nucleic acids in urine: The invention is based upon the discovery that small nucleic acids from non-viral pathogens are able to cross the kidney and are present in urine of a subject when the subject is infected with the non-viral pathogen. These transrenal DNAs are especially prevalent at smaller sizes under about 300 bp.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20070037148 - Compositions and methods for the treatmetn of natural killer cell related diseases: Compositions and methods for improving detection sensitivity in nucleic acid microarray analysis are disclosed, including methods of purifying nucleic acids, methods of synthesizing fluorescent DNA probes, methods of hybridization, and methods of activating a substrate for target molecule attachment are disclosed.... Agent: Genentech, Inc.

20070037175 - Controlling use of oligonucleotide sequences released from arrays: A method for controlling the use of oligonucleotide sequences released from arrays, comprises synthesizing a chemical array of oligonucleotides on a substrate under conditions for producing an array of cleavable oligonucleotides that are blocked from enzymatic reactions after cleavage. Methods may also include receiving a chemical array of cleavable oligonucleotides... Agent: Agilent Technologies, Inc. Legal Department, Dl429

20070037177 - Cyp19a1 polymorphisms: Isolated CYP19A1 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as CYP19A1 allozymes. Methods for determining the aromatase status of an individual also are provided, as are methods for determining if a subject is predisposed to certain clinical conditions.... Agent: Fish & Richardson P.C.

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