Chemistry: molecular biology and microbiology inventions 01/07

20070020607 - Methods for the storage and deglycerolization of red blood cells: The present invention relates to improved methods for the anticoagulation of whole blood and the subsequent refrigerated storage of red blood cells and to improved methods for removing glycerol from frozen-thawed red blood cells.... Agent: Pillsbury Winthrop Shaw Pittman LLP

20070020613 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati

20070020611 - Hematology reference control containing an immature granulocyte component: A hematology reference control containing an immature granulocyte component and the method of making are disclosed. The reference control includes an immature granulocyte component made of processed blood cells for simulating human immature granulocytes, and a suspension medium suitable for delivering the component to a blood analyzer for measurement of... Agent: Beckman Coulter, Inc.

20070020608 - Method for the generation of neural progenitor cells: A rapid, simple and efficient method for the generation of neural progenitor cells from pluripotent/undifferentiated human blastocyst-derived stem (hBS) cells, neural progenitor cells obtained by the method and further differentiation of these cells into the three neural cell lineages, and the use of the neural progenitor cells and the differentiated... Agent: Buchanan, Ingersoll & Rooney PC

20070020609 - Method of determining and prognosing severity of pregnancy toxemia and method of estimating fetus/placenta function under pregnancy toxemia: Provided are: a method for predicting the onset of pregnancy-induced hypertension (PIH) by precisely detecting abnormalities that occur before the onset of PIH (where such abnormalities have been impossible to detect by various conventional testing methods for PIH) while imposing less of a burden on a subject; a method for... Agent: Greenblum & Bernstein, P.L.C

20070020612 - Method of measurement of cellular hemoglobin: A method of measuring cellular hemoglobin of a blood sample includes mixing a blood sample with a permeation reagent, and incubating the sample mixture to permeate cellular membrane of red blood cells and to cause hemoglobin aggregation within the cells; adding a neutralization reagent to inhibit further reactions of the... Agent: Beckman Coulter, Inc.

20070020610 - Methods for ex vivo propagation of adult hepatic stem cells: The present invention is directed to methods for readily propagating somatic liver stem cells. The methods comprise enhancing guanine nucleotide (GNP) biosynthesis, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses asymmetric cell kinetics in the explanted cells. The methods of the invention include pharmacological methods and genetic methods.... Agent: Ronald I. Eisenstein Nixon Peabody LLP

20070020620 - Compositions and methods for coupling a plurality of compounds to a scaffold: Compositions and methods are provided for coupling a plurality of compounds to a scaffold. Compositions and methods are further provided for catalyzing a reaction between at least one terminal alkyne moiety and at least one azide moiety, wherein one moiety is attached to the compound and the other moiety is... Agent: Woodcock Washburn LLP

20070020614 - Development of novel anti-microbial agents based on bacteriophage genomics: A method for identifying suitable targets for antibacterial agents based on identifying targets of bacteriophage-encoded proteins is described. Also described are compositions useful in the identification methods and in inhibiting bacterial growth, and methods for preparing and using such compositions.... Agent: Sughrue Mion, PLLC

20070020617 - Gel microdrops in genetic analysis: The invention provides methods of nucleic acid analysis. Such methods entail forming a population of gel microdrops encapsulating a population of biological entities, each entity comprising a nucleic acid, whereby at least some microdrops in the population each encapsulate a single entity. The population of gel microdrops is then contacted... Agent: Townsend And Townsend And Crew, LLP

20070020619 - Method for identifying motifs and/or combinations of motifs having a boolean state of predetermined mutation in a set of sequences and its applications: Methods for identifying a motif or a combination of motifs having a Boolean state of predetermined mutations in a set of sequences including a) aligning a set of sequences of ordered motifs represented by a single-character code, b) comparing a reference sequence with the set of sequences aligned in step... Agent: Ip Group Of Dla Piper US LLP

20070020616 - Parallel process for protein or virus separation from a sample: A sample is divided into a series of aliquots with the aliquots being subjected to at least two successive parallel separation steps in order to resolve protein or viral components thereof. The separation steps are performed not only on a sample but subsamples each containing a prelabeled tag to afford... Agent: Gifford, Krass, Groh, Sprinkle, Anderson & Citkowski, P.C.

20070020618 - Process to study changes in gene expression in t lymphocytes: Methods are disclosed to identify T lymphocyte genes that are differentially expressed upon exposure to a pathogen (viral or bacterial), immunogen, antigen, or in a sterile inflammatory disease, autoimmune disease, immunodeficiency disease, lymphocytic cancers, or graft versus host rejection. The method involves the preparation of a gene expression profile of... Agent: Morgan Lewis & Bockius LLP

20070020615 - Quantitative prediction method: The present invention concerns methods and systems for analysis of drug resistance in HIV-1. More specifically, the invention provides methods for predicting drug resistance by correlating genotypic information with phenotypic profiles. The methods allow the identification of primary and secondary resistance-associated mutations for new and existing drugs and for calculating... Agent: Philip S. Johnson Johnson & Johnson

20070020627 - Artificial transcription factors: Transcription regulating polypeptides that contain a plurality of DNA binding domains are provided. The polypeptides optionally contain one or more transcription regulating domains. Polynucleotides that encode the polypeptides and use of the polypeptides and polynucleotides are also provided.... Agent: The Scripps Research Institute

20070020649 - Chitosan capture of microorganisms for detection: Chitosan attached to a support surface is used to capture bacteria for detection purposes. Bacteria are captured with chitosan, lysed, and assayed using primers with sequences specific for nucleic acids of target species. The chitosan coated support serves as a capture device to collect or concentrate bacteria from a sample... Agent: Patent Group Attn: J. Kenneth Joung

20070020634 - Composition of orthogonal glutamyl-trna and aminoacyl-trna synthetase pairs and uses thereof: Compositions and methods of producing components of protein biosynthetic machinery that include glutamyl orthogonal tRNAs, glutamyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of glutamyl tRNAs/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.... Agent: Quine Intellectual Property Law Group, P.C.

20070020651 - Compositions and methods for the inference of pigmentation traits: The invention relates to methods for inferring a genetic pigmentation trait of a human subject from a nucleic acid sample or a polypeptide sample of the subject, and compositions for practicing such methods. The methods of the invention are based, in part, on the identification of single nucleotide polymorphisms (SNPs)... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper Rudnick Gray Cary US LLP

20070020662 - Computerized control of high-throughput experimental processing and digital analysis of comparative samples for a compound of interest: The present invention relates to computer-controlled automated high-throughput systems and/or computer-program products to design, prepare, process, and analyze a large number of samples having experimental formulations each containing a compound of interest formulated with differing component combinations and varying concentrations and component identities. The computer-controlled methods of the present invention... Agent: Workman Nydegger (f/k/a Workman Nydegger & Seeley)

20070020629 - Devices for component removal during blood collection, and uses thereof: The invention relates to a device and method for collecting blood whereby certain target components are isolated or removed from the blood sample at the time of collecting the blood, as well as methods for using such devices.... Agent: David W. Highet, Vp And ChiefIPCounsel Becton, Dickinson And Company

20070020666 - Differentially expressed genes in large granular lymphocyte leukemia: The subject invention concerns gene sequences and the use thereof as markers for large granular lymphocyte (LGL) leukemia. The gene sequences of the invention are differentially expressed in LGL. Another aspect of the invention pertains to therapeutic compositions directed to gene expression and gene products of differentially expressed genes in... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070020653 - Dna polymerase: The present invention relates to DNA polymerases. In particular the invention relates to a method for the generation of DNA polymerases exhibiting a relaxed substrate specificity. Uses of mutant polymerases produced using the methods of the invention are also described.... Agent: Palmer & Dodge, LLP Kathleen M. Williams

20070020622 - Dna polymerases and mutants thereof: The present invention provides polypeptides having a nucleotide polymerase activity and method of enhancing polymerase activity. The polypeptides of the present invention may posses both a DNA-dependent DNA polymerase activity and an RNA-dependent DNA polymerase activity, i.e., a reverse transcriptase activity. The polypeptides of the present invention may be used... Agent: Sterne, Kessler, Goldstein & Fox PLLC

20070020626 - Evanescence-based multiplex sequencing method: The invention relates to a method and a device for evanescence-based multiplex sequencing of nucleic acid molecules immobilized on a support.... Agent: John W Mcilvaine

20070020660 - Expression profiles of peripheral blood mononuclear cells for inflammatory bowel diseases: The present invention is directed to the identification of PBMC- and IBD-associated biomarkers that may be used to diagnose inflammatory bowel disease, and optionally, distinguish between PBMCs isolated from a patient with Crohn's disease and PBMCs isolated from a patient with ulcerative colitis. The present invention is further directed to... Agent: Fitzpatrick Cella (wyeth)

20070020637 - Full-length cdna: Novel full-length cDNAs are provided. 2,495 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information... Agent: Foley And Lardner Suite 500

20070020659 - Generation of minicircle dna with physiological supercoiling: Methods for the production of supercoiled DNA minicircles and their use as substrates are described herein.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20070020621 - Genomic plant sequences and uses thereof: The present invention discloses rice genomic promoter sequences. The promoters are particularly suited for use in rice and other cereal crops. Methods of modifying, producing, and using the promoters are also disclosed. The invention further discloses compositions, transformed host cells, transgenic plants, and seeds containing the rice genomic promoter sequences,... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20070020631 - Identification of streptococcus penumoniae serotypes: The present invention relates to molecular methods of serotyping Streptococcus pneunoniae, as well as polynu-cleotides useful in such methods. These methods rely on analysing at least a portion of the nucleotide sequence between the 3′ end of the cpsA gene and the 5′ end of the cpsB gene, and/or analysing... Agent: Marshall, Gerstein & Borun LLP

20070020655 - Identification of tumors and tissues: The invention provides methods for the use of gene expression measurements to classify or identify tumors in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.... Agent: Townsend And Townsend And Crew, LLP

20070020639 - Isothermal locus specific amplification: Methods are provided for amplifying a template DNA strand using locus-specific primers and enzymes. The method involves denaturing template DNA and then annealing a primer to the single-stranded DNA strand. The primer is then extended using a DNA polymerase. The primer is cleaved downstream of the 3′ end of the... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070020664 - Light emission modifiers and their uses in nucleic acid detection, amplification and analysis: The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic acid sequences, e.g., using singly labeled probes. These methods and reagents exploit advantageous properties of thiazine dyes and diazine dyes.... Agent: Quine Intellectual Property Law Group, P.C.

20070020648 - Measurement of mutation load using the p53 gene in human cells from paraffin embedded tissues: A method for determining mutation load in a somatic cell is determined by mutation analysis of the p53 gene. The p53 gene has been found to be a useful indicator of predisposition to spontaneous mutations or prior carcinogen exposure. Cells that contain mutated p53 tend to accumulate the mutant protein.... Agent: Cooper & Dunham, LLP

20070020671 - Method for detecting large mutations and duplications using control amplification comparisons to paralogous genes: Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular... Agent: O'melveny & Myers LLP

20070020644 - Method for detection and characterization of short nucleic acids: A method of detecting and characterizing a target short RNA is provided.... Agent: Patton Boggs LLP

20070020623 - Method for determining homeostasis of the skin: Described herein are processes and devices useful for the identification of genes differentially expressed in skin. Preferably, the processes and devices are useful for the in vitro determination of skin homeostasis. Also described is a combination having a plurality of genes differentially expressed in skin compared to other tissues. Biochips... Agent: Woodcock Washburn LLP

20070020636 - Method for early detection and monitoring of diseases by analysis of cell-surface-bound nucleic acids: This invention relates to noninvasive methods of early detection of different sicknesses, like precancerous state or early stages of cancer development, pathologies of pregnancy, and monitoring of efficacy of anticancer therapy. The method is based on cell-surface extra-cellular nucleic acids from human blood which is divided into plasma and cellular... Agent: Larson And Larson

20070020676 - Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group: A method for manufacturing a biochip and a biochip manufactured by the method are provided. In the biochip manufacturing method, a star-like polyethylene glycol derivative having an epoxy group at its terminal is reacted with a low molecular weight hydrophilic polymer to form a matrix, and a probe is covalently... Agent: Cantor Colburn, LLP

20070020661 - Method for obtaining purified rna from viable oocysts: The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Crytosporidium organisms, and Crytosporidium parvum organisms in particular, which are useful for determining the presence of Cryptosporidium organisms in a test sample. The oligonucleotides of the present invention include hybridization assay probes, helper probes and amplification primers.... Agent: Gen Probe Incorporated

20070020632 - Method for selective inhibition of human n-myc gene in n-myc expressing tumors through antisense and antigen peptido-nucleic acids (pna): The present invention refers to sense and antisense peptido-nucleic acids (PNAs). The present invention further refers to the use of said PNAs for preparing drugs for treating genetic diseases.... Agent: Pearne & Gordon LLP

20070020645 - Method of analysis of samples by determination of a function of specific brightness: A method for characterizing samples having units, by monitoring fluctuating intensities of radiation emitted, scattered and/or reflected by said units in at least one measurement volume, the monitoring being performed by at least one detection means, said method comprising the steps: a) measuring in a repetitive mode a number of... Agent: Jacobson Holman PLLC

20070020668 - Method of manufacturing: A method of manufacturing items in parallel. Selected samples of items to be manufactured are subjected to additional steps in a manufacturing process. If such sample items meet the requisite quality control standard, remaining items are subjected to further manufacturing steps. If the sample items which have been further processed... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070020667 - Methods and compositions for amplifying nucleic acids: Methods and compositions for amplifying nucleic acids are provided.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070020652 - Methods and compositions for rna interference: The invention relates to improved methods of attenuating expression of a target gene in a eukaryotic cell with dsRNA, identifying nucleic acid sequences responsible for conferring a particular phenotype to a cell, alleviating pest infestation in plants, and altering gene expression in an undifferentiated stem cell or the differentiated progeny... Agent: Trask Britt

20070020654 - Methods and kits for preparing nucleic acid samples: The present invention provides methods for preparing nucleic acid samples. The methods of the present invention are particularly amenable for preparing samples that substantially represent the whole transcripts. In some aspects the methods include a step of reducing the amount of ribosomal RNA in a total RNA sample prior to... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070020647 - Methods and reagents for treatment and diagnosis of age-related macular degeneration: The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD.... Agent: Townsend And Townsend And Crew, LLP

20070020670 - Methods for detecting and confirming minimal disease: The present invention provides improved methods for detection of minimal disease. More specifically, the invention provides methods for combining cell sorting with clonality profiling to effectively lower sensitivity limits for disease detection and to provide independent confirmation of the tumor detection without the need for patient specific assay designs.... Agent: Seed Intellectual Property Law Group PLLC

20070020657 - Methods for detecting circulating tumor cells: Nucleic acids and methods for amplifying and detecting mutant BRAF sequences are provided herein. In particular, nucleic acids and methods for amplifying and detecting BRAF sequences that encode the V600E BRAF mutant are provided herein.... Agent: Fish & Richardson P.C.

20070020650 - Methods for detecting proteins: The invention provides methods for detecting antigens comprising forming an antibody/antigen complex in which the antibody is coupled to a polynucleotide having a known sequence. The sequence of the polynucleotide is identified in order to identify the antibody, thereby detecting the antigen.... Agent: Edwards & Angell, LLP

20070020678 - Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides: Methods for evenly distributing tags on collections of molecules are provided. Also provided are assay methods that employ the tagged collections.... Agent: Stephanie Seidman Fish & Richardson P.c

20070020630 - Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents: The present invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening... Agent: Jones Day

20070020673 - Model of autoimmune disease and methods for identifying agents against autoimmune disease: Homozygouse knock-out mice lacking the Aiolos gene are shown to exhibit multiple phenotypes in common with humans suffering from the autoimmune disease Systemic Lupus Erythematosus (SLE). When Aiolos −/− mice are crossed with homozygous knock out mice lacking the OBF-1 transcription factor gene, resultant double knock out mice lack all... Agent: Novartis Corporate Intellectual Property

20070020675 - Modulation of endothelial lipase expression: Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and for diagnosis and treatment of disease associated with expression of endothelial lipase are provided.... Agent: Knobbe, Martens, Olson & Bear, LLP

20070020679 - Modulation of hif1alpha and hif2alpha expression: Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α... Agent: Knobbe, Martens, Olson & Bear, LLP

20070020640 - Molecular encoding of nucleic acid templates for pcr and other forms of sequence analysis: In a first aspect, the present invention provides methods for authenticating a nucleic acid molecule and its sequence with a molecular barcode and batch-stamp. In another aspect, the present invention provides methods for authenticating a nucleic acid amplification product. In a further aspect, the present invention provides compositions for encoding... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20070020674 - Novel gene defective in apeced and its use: The present invention relates to a method for the diagnosis of a disease related to immune maturation and regulation of immune response towards self and nonself, comprising the steps of detecting in a biological specimen the presence of a DNA sequence comprising the sequence of SEQ ID NO:1.... Agent: Ladas & Parry

20070020624 - Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Pseudomonas aeruginosa that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Nina L. Pearlmutter Genome Therapeutics Corporation

20070020680 - Nucleic acid marker ladder for estimating mass: The invention relates to a nucleic acid marker ladder which is a restriction endonuclease digest, wherein a nucleic acid restriction endonuclease digest is a collection of nucleic acid fragments resulting from complete digestion of one or more nucleic acids by one or more restriction endonucleases; the restriction endonuclease digest contains... Agent: Invitrogen Corporation C/o Intellevate

20070020672 - Nucleic acid melting analysis with saturation dyes: Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye... Agent: Ice Miller LLP

20070020635 - Nucleotides for prevention and treatment of bacterial and fungal pathologies: A selectively inducible, single-stranded DNA (ssDNA) expression library, a method for constructing a ssDNA expression library, a method for screening ssDNA using the expression library, and a method for identifying ssDNA molecules that alter expression of bacterial and fungal gene(s) related to cell growth and toxin production and secretion. The... Agent: Osha Liang L.L.P.

20070020643 - Photocleavable bioreactive agents: This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise agents... Agent: Medlen & Carroll, LLP

20070020658 - Polymorphisms in fatty acid binding protein 4 (\"fabp4\") gene and their associations with measures of marbling and subcutaneous fat depth in beef cattle: The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention relates to the identification of single nucleotide polymorphisms (SNPs) within the bovine... Agent: Frommer Lawrence & Haug

20070020665 - Probes and methods for hepatitis c virus typing using single probe analysis: This invention provides compositions and methods for HCV typing, e.g., genotyping and/or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at least five HCV genotypes (for example, selected from genotypes 1, 2, 3, 4, 5 or 6), or assign... Agent: Quine Intellectual Property Law Group, P.C.

20070020663 - Reaction monitoring systems: The present invention provides an apparatus for simultaneously monitoring an array of reaction sites for light indicating that a reaction is taking place at a particula site comprising a charge-coupled device (CCD) arranged so that in use the light from a particular reaction site will impinge upon a particular predetermined... Agent: Dorsey & Whitney LLP Intellectual Property Department

20070020641 - Reagentless, reusable, bioelectronic detectors employing aptamers: A reagentless, reusable bioelectronic DNA, or other oligonucleotide sequence sensor is disclosed. The sensor includes an oligonucleotide (aptamer) probe tagged with a electroactive, redoxable moiety, self-assembled on or near an electrode. This surface-confined oligonucleotide (aptamer) probe structure undergoes hybridization-induced conformational change in the presence of the target which changes the... Agent: Foley & Lardner LLP

20070020669 - Regulation analysis by cis reactivity, racr: Methods of detecting affinity interactions between at least two molecules of interest are provided. The method comprises: a. forming a plurality of interactors by coupling each molecule of interest with at least one nucleic acid moiety comprising an identification sequence element and at an association element; b. promoting an association... Agent: Dinsmore & Shohl, LLP

20070020625 - Sequence of the photorhabdus luminescens strain tt01 genome and uses: The present invention relates to the genomic sequence and to nucleotide sequences encoding polypeptides of Photorhabdus luminescens. The present invention further relates to polypeptides involved in operons involved in the biosynthesis of antibiotics or toxins, as well as polypeptides with activity of the antibiotic or toxin. Uses of the aforementioned... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070020656 - Snapback oligonucleotide probe: The invention relates to compositions and methods for detection of specific nucleic acid sequences during an amplification reaction. The invention further relates to a kit format of said compositions for detection of nucleic acid sequences. The Snapback oligonucleotide probes of the invention comprise a target binding sequence, a hairpin forming... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20070020642 - Structural interaction fingerprint: Disclosed is a method for representing and analyzing 3D target molecule-ligand intermolecular interactions. The method generates structural interaction fingerprints (SIFts) that convert three-dimensional structural interaction information into linear information strings that contains a plurality of information blocks; each of which in turn containing a plurality of information units. By assigning... Agent: Steptoe & Johnson LLP

20070020628 - Tkts as mondifiers of the beta-catenin pathway and methods of use: Human TKT genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of TKT are provided.... Agent: Patent Dept Exelixis, Inc.

20070020633 - Treatment of nucleic acid: The invention provides methods for treating nucleic acid, particularly nucleic acid that is methylated. In one embodiment, the method can include the steps of (a) providing a denaturing environment to a nucleic acid sample; (b) reacting the nucleic acid sample with a bisulphite reagent and incubating the reaction so as... Agent: Knobbe Martens Olson & Bear LLP

20070020646 - Use of id4 for diagnosis and treatment of cancer: Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis. Further, aberrant hypermethylation of ID4 gene promoter region increases risk of metastasis in colorectal and breast cancer.... Agent: Hogan & Hartson L.L.P.

20070020638 - Variants of the adam 12 gene: The invention relates to variants of the ADAM12 gene and the role these variants have to play in the diagnosis and treatment of a number of conditions including cancer, disorders of myogenesis, adipogenesis, cardiac hypertrophy and Alzheimer's disease, and in particular, Late Onset Alzheimer's Disease.... Agent: King & Schickli, PLLC

20070020695 - Compositions and methods for detecting stress-inducible proteins: Compositions and methods for detection of the stress-inducible Hsp70B′ protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B′ and various peptides corresponding, or antigenically equivalent, to the regions. The ability to generate anti-Hsp70B′ antibodies to defined epitopes permits a variety of in vitro and in... Agent: Fish & Richardson PC

20070020686 - Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form... Agent: Klauber & Jackson

20070020687 - Detection of rho proteins: The present invention provides methods of detecting activated Rho GTPase proteins by contacting a solid support with a sample comprising an activated Rho GTPase protein. The solid support is linked to an activated Rho GTPase binding peptide. The activated Rho GTPase protein remains associated with the solid support during the... Agent: Cozen O' Connor, P.C.

20070020693 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati

20070020681 - Hydrolytic substrates for an analyte-dependent enzyme activation system: wherein Y is a moiety capable of being cleaved by a hydrolytic enzyme; L is a detectable label; X is a linking group; Z is a halogen; and R is hydrogen, an alkyl, or a halogen. Compounds of this general formula can be used as substrates in an analyte-dependent enzyme... Agent: Gifford, Krass, Groh, Sprinkle, Anderson & Citkowski, P.C.

20070020689 - Label-free high throughput biomolecular screening system and method: A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a... Agent: Corning Incorporated

20070020688 - Measurement method using biosensor: It is an object of the present invention to provide a method for carrying out on a same biosensor both of the measurement of the amount of a physiologically active substance immobilized on a biosensor substrate and the measurement of the biological activity of the above physiologically active substance, thereby... Agent: Sughrue Mion, PLLC

20070020690 - Method for site-specific protein modifications: A method for site-specific modification of protein molecules includes providing a protein molecule having at least first and second non-terminal Cys residues at respective first and second sites within the protein molecule, providing a blocking molecule that is suitable to interact with the protein molecule to selectively block the second... Agent: Venable LLP

20070020692 - Methods of assaying connective tissue growth factor: The present invention relates to methods of detection and quantitation of connective tissue growth factor (CTGF), and diagnosis and detection of various CTGF-associated diseases and disorders.... Agent: Fibrogen, Inc. Intellectual Property Department

20070020683 - Monoclonal antibodies for detection of urinary trypsin inhibitors: Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and aggregates thereof.... Agent: Kelley Drye & Warren LLP

20070020691 - Multiplex determination of lipid specific binding moieties: To perform large-scale multiplex analysis of lipid-specific binding, lipid microarrays were developed. Lipids identified as disease associated, or analogs there, can be tolerogenic to patients suffering from autoimmune disease. Lipid array analysis has revealed anti-lipid antibodies in patients with immune disorders, and may contribute to the pathogenesis of disease.... Agent: Bozicevic, Field & Francis LLP

20070020694 - Prodrug compounds with isoleucine: The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by an enzyme associated with the target cell. Methods of... Agent: Lahive & Cockfield, LLP

20070020685 - Secretion of antibodies without signal peptides from bacteria: The present invention is directed generally to compositions and methods for obtaining secretion of antibodies or antigen-binding antibody fragments from prokaryotes without the need for a signal peptide through making use of mutant host strains with altered secretory properties. In particular, the invention provides host cells and methods for obtaining... Agent: Mcdermott Will & Emery LLP

20070020684 - Structure of a glucocorticoid receptor ligand binding domain comprising an expanded binding pocket and methods employing same: A solved three-dimensional crystal structure of a glucocorticord receptor (GR) α ligand binding domain polypeptide is disclosed, in the form of a crystalline glucocorticord receptor α ligand binding domain polypeptide in complex with the ligand fluticasone propionate (FP) and a peptide derived from the co-activator TIF2. The GR/FP/TIF2 structure includes... Agent: David J Levy, Corporate Intellectual Property Glaxosmithkline

20070020682 - Use of prion conversion modulating agents: The use of Apolipoprotein B, Apolipoprotein E, fragments and mimetics thereof is provided for diagnostic, detection, prognostic and therapeutic applications In prion diseases. More specifically, the invention provides the use of Apolipoprotein B or fragments thereof for modulating or identifying modulators of the prion protein replication which are implicated in... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070020696 - Appl proteins as rab5 effectors: The present invention relates to an in vivo-assay to screen for anti-proliferative drugs, the assay comprising the steps of: (a) contacting cells of a primary cell culture or of an established cell line with a candidate substance, (b) subsequently or concomitantly with a candidate substance, contacting the cells with a... Agent: Fulbright & Jaworski L.L.P.

20070020698 - Igf binding proteins: IGFBP-3 fusion proteins are provided that are useful, for example, in cell-based assays, as IGF antagonists, and in mapping IGF-I and IGF-II binding sites on other molecules such as wild-type IGFBP-3 and IGF agonist peptides identified by phage display. Methods for making such fusion proteins are also provided.... Agent: Heller Ehrman LLP

20070020697 - Virtual flow cytometry on immunostained tissue-tissue cytometer: The invention provides an automated method of single cell image analysis which determines cell population statistic, applicable in the field of pathology, disease or cancer diagnosis, in a greatly improved manner over manual or prior art scoring techniques. By combining the scientific advantages of computerized automation and the invented method,... Agent: Hernani Cualing

20070020704 - Diaryl ureas with kinase inhibiting activity: The present invention provides methods of using aryl ureas to treat diseases and conditions associated with signal transduction pathways comprising at least one of raf, VEGFR, PDGFR, p38 and/or FLT-3. The present invention also provides compositions and methods for identifying conditions and diseases which can be modulated with compounds of... Agent: Millen, White, Zelano & Branigan, P.C.

20070020703 - Use of compositions comprising a soluble form of hla-g in the treatment of blood diseases: The invention relates to the use of compositions comprising a soluble form of HLA-G in the treatment of blood and circulatory system diseases (anemias and ischaemias).... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070020710 - Antibodies that spefically recognize inactive psa, and uses thereof: An immunoassay for the quantitative determination of inactive, non-zymogen, free PSA in a biological sample taken from an individual, including contacting the biological sample with a reagent, where the reagent comprises an antibody or antibody fragments that bind specifically to inactive, non-zymogen, free PSA, the antibody being a purified polyclonal... Agent: Oliff & Berridge, PLC

20070020709 - Igf binding proteins: IGFBP-3 fusion proteins are provided that are useful, for example, in cell-based assays, as IGF antagonists, and in mapping IGF-I and IGF-II binding sites on other molecules such as wild-type IGFBP-3 and IGF agonist peptides identified by phage display. Methods for making such fusion proteins are also provided.... Agent: Heller Ehrman LLP

20070020705 - Method for prognostic evaluation of carcinoma using anti-p-lap antibody: The present invention provides a reagent for prognostic evaluation of carcinoma patients, comprising an anti-P-LAP antibody as an active ingredient. Also, the present invention provides a method for determination of P-LAP which is a prognostic factor in carcinoma patients comprising (a) a step of contacting carcinoma tissues obtained from carcinoma... Agent: Drinker Biddle & Reath (dc)

20070020708 - Paad domain-containing polypeptides, encoding nucleic acids, and methods of use: The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NACHT domains and ARED domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that... Agent: Mcdermott, Will & Emery

20070020707 - Tissue inhibitor of matrix metalloproteinases type-1 (timp-1) as a cancer marker: The present invention describes a method for determining whether an individual is likely to have cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.... Agent: Roberts, Mlotkowski & Hobbes

20070020706 - Truncated proteins as cancer markers: Methods/reagents for detecting and/or treating cancers or potential cancers are disclosed. In one embodiment, methods and reagents for detecting truncated forms of P2X7 protein in cells are described. In one embodiment, methods and reagents for increasing the amount and/or activity of full-length P2X7 in cells are described. In one embodiment,... Agent: Medlen & Carroll, LLP

20070020711 - Fungal antigen immunoassay: The present disclosure relates to methods for detecting a fungal antigen in a physiological specimen. The present invention includes methods and materials for testing for antigens associated with endemic mycoses as well as quantitative analysis of the test results.... Agent: Indianapolis Office 27879 Brinks Hofer Gilson & Lione

20070020712 - Use of ylqf, yqeg, yybq, and ysxc, essential bacterial genes and polypeptides: Disclosed are genes found in Streptococcus pneumoniae that are essential for survival for a wide range of bacteria. These genes are termed “S-ylqF,” “S-yqeG,” “S-yybQ,” “S-yerL,” and “S-ysxC.” These genes and the polypeptides that they encode, as well as homologs and orthologs thereof can be used to identify antibacterial agents... Agent: Fish & Richardson PC

20070020699 - Lateral flow assay and device using magnetic particles: A complex including magnetic particle bound to a metal colloid. The complex may be part of a reagent for use in a method for determining analytes. The reagent may include a binding partner specific for an analyte. The reagent may further include a first label that is distinguishable from a... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070020700 - Lateral flow assay and device using magnetic particles: A complex including magnetic particle bound to a metal colloid. The complex may be part of a reagent for use in a method for determining analytes. The reagent may include a binding partner specific for an analyte. The reagent may further include a first label that is distinguishable from a... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070020701 - Magnetic resonance system and method to detect and confirm analytes: A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20070020713 - Antibodies to the fuel oxygenate mtbe and use thereof in immunoassays: Immunoassay of methyl tert-butyl ether (MTBE) and related fuel oxygenates and their breakdown products is performed using a monoclonal antibody produced using a hapten with a CH3—O—C(CH3)2—CH2-moiety, preferably CH3—O—C(CH3)2—(CH2)3—CH(CH3)—CH2—CHO conjugated to a carrier protein.... Agent: Stites & Harbison PLLC

20070020714 - Fluorescent indicator proteins having increased signal intensity to concentration of sugars and use thereof: A protein biosensor having increased signal intensity to sugar concentration and the use thereof. A fluorescent indicator protein is described, in which fluorescent proteins of different emission ranges are fused to both ends of a binding protein undergoing a confornational change due to binding of sugars, such that a change... Agent: Intellectual Property / Technology Law

20070020716 - Coronary endothelial dysfunction: This document provides methods and materials related to assessing coronary endothelial dysfunction (CED) conditions as well as methods and materials related to treating coronary conditions. For example, methods and materials for determining whether or not a mammal has CED by determining whether or not a sample from the mammal contains... Agent: Fish & Richardson P.C.

20070020715 - Novel fluorogenic substrates for beta-lactamase gene expression: in which W is a hydrogen, alkyl, substituted heteroalkyl, aryl, a heteroaryl, substituted heteroaryl or a CN; and, S is an integer from 0 to 5; W′ and W″ are independently hydrogen, alkyl, substituted heteroalkyl, aryl, substituted heteroaryl, (═O) or OR10; wherein R10 is hydrogen, substituted alkyl, heteroalkyl, substituted heteroalkyl,... Agent: Quine Intellectual Property Law Group, P.C.

20070020717 - Methods and compositions for modulating cox: The invention provides an assay for determining whether a test agent is a COX modulator. In general terms, the assay includes: determining whether a test agent modulates binding of a PDZ-containing polypeptide to a COX PL-containing polypeptide. The PDZ-containing polypeptide may contain the PDZ domain of PDZ domain of MAGI1,... Agent: Townsend And Townsend And Crew, LLP

20070020718 - Method for quantitative analysis of proline hydroxylation-induced interactions between hif-1 and vbc protein complex using fluorescence polarization: The present invention relates to a method for analyzing the interaction between HIF-1 peptide and VBC protein using fluorescence polarization, more precisely, a method for quantitative analysis of formation of HIF-1-VBC protein complex which is composed of the steps of 1) preparing a fluorescent probe by attaching a fluorescein to... Agent: Jhk Law

20070020721 - Blood analyzing method and blood analyzer: A blood analyzing method is described that includes steps of: preparing a measurement sample by hemolyzing red blood cells in a blood specimen, the measurement sample containing particles; irradiating a light on the measurement sample to detect two or more types of optical information reflecting characters of the particles in... Agent: Brinks Hofer Gilson & Lione

20070020720 - Method for the detection and/or identification of bacteria present in a sample: f. the temperature T1 is higher than the temperature T2 such that a defined volume of culture medium is transferred from the first container to the second container, g. the presence or absence of bacteria is determined and/or the bacteria are identified within the detection system.... Agent: Oliff & Berridge, PLC

20070020719 - Selective culture medium for the isolation and/or detection of species in the streptococcus genus: The medium includes specific ratios of mixtures of nutritive bases, rich in compounds of protein origin (polypeptides, peptides, proteoses, and aminoacids) and vitamins, which facilitate an abundant growth of the target species. In addition, the inclusion of the blood enzymatic hydrolyzate, guarantees the presence in the medium of blood-derived substances... Agent: Lackenbach Siegel, LLP

20070020724 - 94 human secreted proteins: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing... Agent: Human Genome Sciences Inc Intellectual Property Dept.

20070020723 - Ceramide kinase-like proteins: A ceramide kinase like protein encoded by a polynucleotide of SEQ ID NO: 1 to SEQ ID NO: 9 and its use.... Agent: Novartis Corporate Intellectual Property

20070020727 - Exo-specific amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof: This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exospecifity.... Agent: Genencor International, Inc.

20070020732 - Mast cell-specific signal transducer and cdna thereof: The present invention provides a signal transducer specifically expressed in mouse mast cells that has the amino acid sequence of SEQ ID No. 2, a signal transducer specifically expressed in human mast cells that has the amino acid sequence of SEQ ID No. 4, polynucleotides encoding these proteins, an expression... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070020730 - Method for overexpression of zwitterionic polysaccharides: The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular... Agent: Wolf Greenfield & Sacks, PC

20070020728 - Muteins of apolipoprotein d: A method of generating a mutein of human apolipoprotein D having detectable binding affinity to a given non-natural ligand of apolipoprotein D is disclosed, which comprises the steps of subjecting apolipoprotein D to mutagenesis at the sequence positions 34 to 38, 60, 62 to 66, 68, 89 to 93, 115,... Agent: Foley And Lardner LLP Suite 500

20070020729 - Novel collectin: Novel collectin related molecules i.e., a novel collectin gene comprising a nucleotide sequence set out in SEQ ID NO: 1, and a novel collectin comprising an amino acid sequence set out in SEQ ID NO: 2, which are expected to exhibit anti-bacterial, anti-viral activity or the like especially in human... Agent: Marshall, Gerstein & Borun LLP

20070020726 - Novel glutaminase, its gene and a method of producing it: Glutaminase is purified from an Aspergillus oryzae, its partial amino acid sequence is determined, a partial sequence of glutaminase gene is obtained by PCR based on the obtained information, and DNA fragments containing glutaminase gene from Aspergillus oryzae genomic library and cDNA library, and Aspergillus nidulans genomic library by hybridization... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070020725 - Prokaryotically produced antibodies and uses thereof: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.... Agent: Merchant & Gould PC

20070020722 - Telomere elongation: The present invention relates, in general, to telomeres, and, in particular, to a method or effecting telomere elongation in mammalian cells. The invention further relates to a protein suitable for use in such a method and to nucleic acid sequences encoding same.... Agent: Nixon & Vanderhye, PC

20070020731 - Thermostable amylase polypeptides, nucliec acids encoding those polypeptides and uses thereof: This is invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered thermostability.... Agent: Genencor International, Inc.

20070020733 - Compositions and methods for detection of ehrlichia canis and ehrlichia chaffeensis antibodies: The invention provides methods and compositions for the detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies and antibody fragments.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20070020734 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department

20070020735 - Il-17 homologous polypeptides and therapeutic uses thereof: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide... Agent: Sidley Austin LLP Attn: Dc Patent Docketing

20070020736 - Efficient production of oligosaccharides using metabolically engineered microorganisms: The present invention relates to the enzymatic synthesis of oligosaccharides, particularly, sialylated oligosaccharides comprising the carbohydrate moeities of the gangliosides GM3, GD3, and GT3.... Agent: Foley And Lardner LLP Suite 500

20070020737 - Hyaluronan synthases and methods of making and using same: A functionally active hyaluronan synthase having at least one modified amino acid residue therein as compared to a corresponding functionally active native hyaluronan synthase such that the functionally active hyaluronan synthase has an altered enzymatic activity as compared to the corresponding functionally active native hyaluronan synthase is disclosed. The altered... Agent: Dunlap, Codding & Rogers P.C.

20070020738 - Production method of capsinoid by dehydrating condensation, stabilizing method of capsinoid, and capsinoid composition: f

20070020740 - Blocking sporulation by inhibiting spoiie: We have shown that the control of solventogenesis and sporulation can be genetically uncoupled in C. acetobutylicum. In strain 824(pASspo), the absence of SpoIIE causes sporulation to be blocked at stage II. The cell remains in a vegetative state, and this allows solvent production to proceed for longer and for... Agent: Baker & Mckenzie LLP

20070020739 - Enzyme gene participating in the synthesis of polyester and process for producing polyester using the same: This invention relates to a method of producing polyesters resulting from homopolymerization or copolymerization of a 3-hydroxyalkanoic acid(s) and having biodegradability and good physical properties using yeasts as hosts. By constructing at least one enzyme gene involved in polyester synthesis by adding a DNA coding a peroxisome-targeting signal, introducing an... Agent: John C Altmiller Kenyon & Kenyon

20070020741 - Process for preparing enantiomer-enriched alpha-hydroxycarboxylic acids and amides: The present invention describes an enzymatic process for preparing enantiomer-enriched α-hydroxycarboxylic acids and amides which comprises, in one step, the conversion of a carbonyl compound to the corresponding acid/amides via the intermediate stage of a cyanohydrin. The invention also provides a reaction system operating in such a way and a... Agent: Fitch, Even, Tabin & Flannery

20070020742 - Glycerol-3-phosphate phosphatase and glycerol-3-phosphate dehydrogenase from candida albicans, genes encoding the same, vector and host cell containing the genes, and method for producing glycerol using the host cell: Provided are a polypeptide having glycerol-3-phosphate dehydrogenase activity and a 80% or more homology to an amino acid sequence as set forth in SEQ ID NO: 1 and a polypeptide having glycerol-3-phosphate phosphatase activity and a 80% or more homology to an amino acid sequence as set forth in SEQ... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20070020744 - Enzyme compositions that enhance the flavor of food and beverages: The invention provides enzyme compositions that are useful for enhancing the nutritional value and/or flavor of food and beverage products. The invention also provides a process for producing such food and beverage products that have enhanced nutritional and/or flavor profiles.... Agent: Foley And Lardner LLP Suite 500

20070020743 - Undecaprenyl pyrophosphate synthase (upps)enzyme and methods of use: A novel Streptococcus pneumoniae UPPS native crystalline structure and a novel Streptococcus pneumoniae UPPS complex with the substrates FPP and IPP are identified.... Agent: David J Levy, Corporate Intellectual Property Glaxosmithkline

20070020745 - Method for crystallizing human gsk3 and novel crystal structure thereof: The invention provides the three-dimensional structure of a construct of human glycogen synthase kinase 3 (GSK3); crystals of a construct of human glycogen synthase kinase 3-β (GSK3-β) containing the protein's catalytic kinase domain; a method for crystallizing the protein construct to provide a GSK3 crystal sufficient for structure determination; and... Agent: Chiron Corporation Intellectual Property - R440

20070020746 - Staphylococcus aureus polynucleotides and sequences: The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media,... Agent: Human Genome Sciences Inc Intellectual Property Dept.

20070020747 - Composition for eliminating ethidium bromide and use thereof: The present invention is related to a composition and a method for eliminating ethidium bromide.... Agent: Harness, Dickey & Pierce, P.L.C

20070020748 - Apparatus for screening proptein crystallization conditions: The present invention is intended to provide an apparatus for screening protein crystallization conditions that can screen protein crystallization conditions efficiently by the vapor diffusion method using the sitting drop technique. In order to achieve the above-mentioned object, in an apparatus for screening protein crystallization conditions that screens protein crystallization... Agent: Hamre, Schumann, Mueller & Larson P.C.

20070020749 - Materials and methods for creating imaging layers: The present invention provides patterned features of dimensions of less than 50 nm on a substrate. According to various embodiments, the features may be “Manhattan” style structures, have high aspect ratios, and/or have atomically smooth surfaces. The patterned features are made from polymer brushes grafted to a substrate. In some... Agent: Beyer Weaver & Thomas, LLP

20070020750 - Culture chamber, culture apparatus and liquid supplying method for cell or tissue cultivation: A culture chamber which cultivates a culture object by using a culture liquid has a culture space part which houses the culture object together with the culture liquid, an introducing part (an introducing port) which introduces the culture liquid into the culture space part, a discharging part (a discharging port)... Agent: Connolly Bove Lodge & Hutz LLP

20070020751 - Bioreactor, in particular for nmr spectroscopy: A description is given of a bioreactor (1), in particular for NMR spectroscopy, comprising a container (7) capable of containing a cell culture, a first inlet line (6) for the inward flow of a culture medium to the inside of the container and a second outlet line (9, 10) for... Agent: James C. Eaves Jr. Greenebaum Doll & Mcdonald PLLC

20070020752 - Cell culturing device and system: Devices, systems, and methods for culturing cells and providing a contaminant-free connection are disclosed. A cell culture device comprises a container having first and second side walls wherein the first and second side walls are gas permeable, the device further comprising a female connector and a male connector. At least... Agent: Leydig Voit & Mayer, Ltd

20070020753 - Condensation reducing/eliminating container: The present invention provides methods for reducing the amount of condensation in a container by providing a container comprising a lid, wherein the amount of condensation in the container is reduced by: increasing all or a portion of the thickness of the lid; insulating the lid; or combinations thereof. The... Agent: Dinsmore & Shohl LLP

20070020754 - Cell handling device, human tissue regeneration composition, and human tissue regeneration method: The main objects of the present invention, which relates to regenerative medical treatments, are to enable (i) storage and conveyance of harvested or cultured cells without contamination occuring (ii) simple injection of the cells into a living body. To achieve these objects, cells harvested from a living body, or cells... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070020756 - Methods of culturing, storing, and inducing differentiation in cells, instrument for use in the methods, method of using the instrument, and medical biomaterial: The present invention provides methods of culturing or storing cells for a prolonged period while suppressing a loss of functions of the cells during storage, by applying centrifugal force or pressure such as hydraulic pressure to the cells to form compact bodies, particularly aggregates, in which a state of high... Agent: Leydig Voit & Mayer, Ltd

20070020755 - Stage specific follicle maturation systems: Improved three dimensional culture systems for the maturation and development of individual follicles and oocytes. The present invention optimizes preantral two-layer secondary follicle growth and maturation, preantral multilayer secondary follicle growth and maturation, and oocyte developmental competence by encapsulating individual follicles into polymeric hydrogel beads having optimal concentrations of polysaccharide.... Agent: Todd S. Parkhurst Holland & Knight LLP

20070020757 - Methods for expansion and analysis of cultured hematopoietic stem cells: Methods and kits for propagating hematopoietic stem cells are provided. The methods comprise culturing cells in medium comprising one or more angiopoietin-like proteins, under conditions sufficient for expansion of HSCs. Angiopoietin-like proteins include angiopoietin-like protein 2, angiopoietin-like protein 3, angiopoietin-like protein 4, angiopoietin-like protein 5, angiopoietin-like protein 7, and microfibrillar-associated... Agent: Proskauer Rose LLP

20070020758 - Method for the isolation and expansion of cardiac stem cells from biopsy: Method for the isolation, expansion and preservation of cardiac stem cells from human or animal tissue biopsy samples to be employed in cell transplantation and functional repair of the myocardium or other organs. Cells may also be used in gene therapy for treating genetic cardiomyopathies, for treating ischemic heart diseases... Agent: Albert Wai-kit Chan Law Offices Of Albert Wai-kit Chan

20070020759 - Therapeutic reprogramming of germ line stem cells: Pluripotent therapeutically programmed cells and methods for making such cells are provided. The pluripotent therapeutically programmed cells are post-natal stem cells which have been matured such that they represent either a more differentiated state or a less differentiated state after contact with stimulatory factors. The pluripotent therapeutically reprogrammed cells are... Agent: Preston Gates & Ellis LLP

20070020760 - Medium supplement and animal cell culture medium: An object of the present invention is to provide a medium supplement for animal cell culture and an animal cell culture medium. The present invention relates to a medium supplement for animal cell culture comprising sericin or a sericin derivative and an animal cell culture medium comprising at least said... Agent: Ladas & Parry LLP

20070020761 - Solid surface for biomolecule delivery and high-throughput assay: The present invention is related to a method for introducing biomolecules, such as nucleic acids, into cells by culturing cells on a solid surface which is coated with a transfection reagents and biomolecules.... Agent: Knobbe Martens Olson & Bear LLP

20070015131 - Extracorporeal organ conservation: Storage system for extracorporeal storage of organs. The storage system artificially maintains or regenerates the vital functions of organs, including limbs and tissue lobes. The storage system comprises an organ perfusion chamber filled with dialysate as a storage fluid and equipped with a temperature control device that maintains the temperature... Agent: Bohan, Mathers & Associates, LLC

20070015136 - Controlling dendritic cell maturation state in the lymphoid tissue equivalent of an artificial immune system: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates... Agent: Merchant & Gould PC

20070015133 - Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein: The invention relates to the field of aqueous solutions comprising a protein. More specifically, the invention relates to the detection and/or removal of conformationally altered proteins and/or peptides comprising a cross-β structure from an aqueous solution comprising a protein. The invention provides methods for detecting and/or removing proteins and/or peptides... Agent: Trask Britt

20070015135 - Methods and computer systems for analyzing high-throughput assays: The present invention provides methods and computer programs for detecting variations in measurements of a biological variable, e.g., variations in cell viability, under different conditions, e.g., with or without treatment of a drug, under the treatments of different drugs, or under different environmental conditions. The methods and programs of the... Agent: Jones Day

20070015138 - Methods for identifying agents and conditions that modulate neurogenesis: Methods and tools for identifying agents and conditions that modulate neurogenesis are disclosed. The disclosure also relates to methods and tools for identifying populations of neural stem cells suitable for transplantation.... Agent: Townsend And Townsend And Crew, LLP

20070015137 - Microfluid device and method of producing diffusively built gradients: A microfluid device for producing diffusively built gradients comprising a bottom plate and a cover plate, wherein the cover plate has recesses and is connected to the bottom plate in a liquid-tight manner so that the recesses form at least two reservoirs and one observation chamber, which connects the reservoir,... Agent: Ip Strategies

20070015134 - Quantitative stabilized cell reference control products and methods: The invention relates to quantitative stabilized cell reference control products, their methods of manufacture, and their methods of use. Receptors, antigens, and ligands associated with stabilized cells may be quantitated by the methods of the present invention. Those quantitated stabilized cells may then be used to determine the receptor, antigen,... Agent: Sterne Kessler Goldstein & Fox, P.l.l.c.

20070015132 - System and methods for measuring at least one metabolic rate of a plurality of cells: A system and methods for calculating at least one unknown metabolic flux of a plurality of cells. In one embodiment, the method includes the steps of constructing a metabolic network having a plurality of reaction components, the reaction components representing at least glycolysis, reduction of pyruvate to lactate, TCA cycle,... Agent: Morris Manning Martin LLP

20070015139 - Biological reagents and methods to verify the efficiency of sample preparation and nucleic acid amplification and/or detection: This invention relates to reagent comprising: any one of cells, viral particles, organelles, parasites, cells comprising organelles, cells comprising viral particles, cells comprising parasites, cells comprising bacterial cells and any combination thereof, the cells, viral particles, organelles or parasites comprising at least one nucleic acid sequence serving as an internal... Agent: Oliff & Berridge, PLC

20070015142 - Detection of hiv-1 by nucleic acid amplification: Nucleic acid sequences and methods for detecting HIV-1 nucleic acid (LTR and pol sequences) in biological samples by detecting amplified nucleic acids are disclosed. Kits comprising nucleic acid oligomers for amplifying HIV-1 nucleic acid present in a biological sample and detecting the amplified nucleic acid are disclosed.... Agent: Gen Probe Incorporated

20070015140 - Method of examining specimen and specimen container to be used in the examination method: A method of immunologically examining a specimen which comprises attaching a cap having a filter impregnated with a labeled antibody enclosed therein to a container body containing a diluted liquid specimen, pouring the diluted liquid specimen from the container into a test device, observing the reaction and thus examining the... Agent: Sonnenschein Nath & Rosenthal LLP For Paula Evans

20070015143 - Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays: For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted... Agent: Leydig Voit & Mayer, Ltd

20070015141 - Process for adjusting the diameter of gold particles and colloidal gold solution: A method for estimating the particle diameter distribution width of gold colloid based on the measurement of, in addition to the maximum absorption wavelength, a ratio (AλX/Aλmax) of the absorbance (AλX) at a wavelength differing from the maximum absorption wavelength to the absorbance (Aλmax) at the maximum absorption wavelength of... Agent: Sonnenschein Nath & Rosenthal LLP For Paula Evans

20070015162 - 99 human secreted proteins: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic... Agent: Human Genome Sciences Inc Intellectual Property Dept.

20070015156 - Aberrantly methylated genes in pancreatic cancer: The present invention provides a method for detecting pancreatic carcinoma in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant... Agent: Dla Piper US LLP

20070015151 - Analytical chip with an array of immobilized specific recognition elements for the determination of clinically relevant bacteria and analytical method based thereon: The invention is related to an analytical chip for the simultaneous determination of one or more different bacterial 16S-rRNA in a liquid sample comprising—an evanescent field measurement platform, e.g. an optical waveguide, as a solid carrier and—a plurality of specific recognition elements immobilized in discrete measurement areas of known location... Agent: Wenderoth, Lind & Ponack, L.L.P.

20070015202 - Atlastin: The present invention relates to methods and compositions of a novel gene and the peptide encoded by the gene. Mutations in the gene, named atlastin, are factors in the disease Hereditary Spastic Paraplegia and related disorders. The present invention will be used for the in the research, diagnosis and treatment... Agent: Medlen & Carroll, LLP

20070015183 - Biomarkers for huntington's disease: The invention relates, in part, to specific genes and set of genes that are selectively expressed in Huntington's disease and their use for the diagnosis and staging of HD. Additionally, the selectively expressed genes are useful in methods to assess HD pathogenesis in cells, tissues, and subjects, and in the... Agent: Wolf Greenfield & Sacks, PC

20070015164 - Dairy cattle breeding for improved milk production traits in cattle: Nucleic acid molecules comprising a SNP site selected from the group consisting of position 1296 of bovine uterine milk protein (UTMP) coding sequence (SEQ ID NO: 1), position 213 of bovine signal transducer and activator of transcription (STAT1) coding sequence (SEQ ID NO: 2), position 8514 of the osteopontin (OPN)... Agent: Baker Donelson Bearman Caldwell & Berkowitz, PC

20070015154 - Differentially expressed nucleic acids that correlate with ksp expression: Nucleic acids that differentially expressed in certain tumors are provided. A variety of classification, screening, diagnostic and treatment methods are provided based upon these differentially expressed nucleic acids. Devices and kits for performing such methods are also disclosed.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070015175 - Dna biochip and methods of use: The subject invention concerns materials and methods for detecting nucleic acid sequences. One aspect of the invention concerns a silicon-based “biochip” comprising nucleic acid immobilized thereon. In one embodiment, the silicon comprises microcavities. The nucleic acid to be assayed for the presence of one or more target nucleic acid sequences... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20070015198 - Dna sequence detection of nucleated red blood cells: Genetic modification or selection of avians requires that large numbers of birds be genetically analyzed for sequences of interest. Typically, DNA is extracted on an individual basis from samples taken from the birds. Current methods of DNA extraction extract the DNA from blood or other tissues using tedious and time-consuming... Agent: Avigenics, Inc.

20070015172 - Expression profiles for microbial infection: The invention provides methods for identifying markers of microbial infection, diagnosing microbial infections, and identifying the specific pathogen(s) involved in a microbial infection based on the signature patterns of gene expression induced in a host in response to different pathogens. The invention includes compositions and kits comprising newly identified markers... Agent: Lahive & Cockfield

20070015148 - Gene expression profiles in breast tissue: The present invention results from the examination of tissue from breast carcinomas to identify genes differentially expressed between tumor biopsies and normal tissue. The invention includes diagnostic and screening methods using these genes as well as solid supports comprising oligonucleotide arrays that are complementary to or hybridize to the differentially... Agent: Morgan Lewis & Bockius LLP

20070015182 - Generation of single-strand circular dna from linear self-annealing segments: The present invention provides a method for the rapid simultaneous production of a plurality of single-stranded DNA circles having a predetermined size and nucleotide sequence using pre-designed hairpin oligonucleotides containing complementary sequences for directing ligation to form dumbbell-shaped monomers followed by heat denaturation to yield single-stranded DNA circles.... Agent: Needle & Rosenberg, P.C.

20070015193 - Glutathione s-transferase sequence variants: Isolated GSTO2 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as GSTO2 allozymes. Methods for determining if a subject contains a GSTO2 sequence variant also are described.... Agent: Fish & Richardson P.C.

20070015196 - Growth factor with acts through erb b-4 rtk: A novel ErbB-4 ligand, referred to herein as Neuregulin-4 (NRG-4) is disclosed as well as polynucleotide sequences encoding NRG-4, oligonucleotides and oligonucleotide analogs derived from polynucleotide sequences, a display library displaying short peptides derived from NRG-4, antibodies recognizing NRG-4, peptides or peptide analogs derived from NRG-4, and pharmaceutical compositions and... Agent: Martin D. Moynihan Prtsi, Inc.

20070015174 - High throughput formulation screening of drug candidates: Methods for screening compounds for their solubility and their solution stability in a variety of diverse formulations and sets of diverse formulations useful for screening compounds for their solubility and their solution stability.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20070015144 - Human cdnas and proteins and uses thereof: The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents i