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Chemistry: molecular biology and microbiology January USPTO class patent listing 01/07Below are recently published patent applications awaiting approval from the USPTO. Recent week's RSS XML file available below.
Listing for abstract view: USPTO application #, Title, Abstract excerpt,Patent Agent. Listing format for list view: USPTO National Class full category number, title of the patent application. 01/25/2007 > 153 patent applications in 41 patent subcategories. USPTO class patent listing
20070020607 - Methods for the storage and deglycerolization of red blood cells: The present invention relates to improved methods for the anticoagulation of whole blood and the subsequent refrigerated storage of red blood cells and to improved methods for removing glycerol from frozen-thawed red blood cells.... Agent: Pillsbury Winthrop Shaw Pittman LLP
20070020613 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati
20070020611 - Hematology reference control containing an immature granulocyte component: A hematology reference control containing an immature granulocyte component and the method of making are disclosed. The reference control includes an immature granulocyte component made of processed blood cells for simulating human immature granulocytes, and a suspension medium suitable for delivering the component to a blood analyzer for measurement of... Agent: Beckman Coulter, Inc.
20070020608 - Method for the generation of neural progenitor cells: A rapid, simple and efficient method for the generation of neural progenitor cells from pluripotent/undifferentiated human blastocyst-derived stem (hBS) cells, neural progenitor cells obtained by the method and further differentiation of these cells into the three neural cell lineages, and the use of the neural progenitor cells and the differentiated... Agent: Buchanan, Ingersoll & Rooney PC
20070020609 - Method of determining and prognosing severity of pregnancy toxemia and method of estimating fetus/placenta function under pregnancy toxemia: Provided are: a method for predicting the onset of pregnancy-induced hypertension (PIH) by precisely detecting abnormalities that occur before the onset of PIH (where such abnormalities have been impossible to detect by various conventional testing methods for PIH) while imposing less of a burden on a subject; a method for... Agent: Greenblum & Bernstein, P.L.C
20070020612 - Method of measurement of cellular hemoglobin: A method of measuring cellular hemoglobin of a blood sample includes mixing a blood sample with a permeation reagent, and incubating the sample mixture to permeate cellular membrane of red blood cells and to cause hemoglobin aggregation within the cells; adding a neutralization reagent to inhibit further reactions of the... Agent: Beckman Coulter, Inc.
20070020610 - Methods for ex vivo propagation of adult hepatic stem cells: The present invention is directed to methods for readily propagating somatic liver stem cells. The methods comprise enhancing guanine nucleotide (GNP) biosynthesis, thereby expanding guanine nucleotide pools. This in turn conditionally suppresses asymmetric cell kinetics in the explanted cells. The methods of the invention include pharmacological methods and genetic methods.... Agent: Ronald I. Eisenstein Nixon Peabody LLP
20070020620 - Compositions and methods for coupling a plurality of compounds to a scaffold: Compositions and methods are provided for coupling a plurality of compounds to a scaffold. Compositions and methods are further provided for catalyzing a reaction between at least one terminal alkyne moiety and at least one azide moiety, wherein one moiety is attached to the compound and the other moiety is... Agent: Woodcock Washburn LLP
20070020614 - Development of novel anti-microbial agents based on bacteriophage genomics: A method for identifying suitable targets for antibacterial agents based on identifying targets of bacteriophage-encoded proteins is described. Also described are compositions useful in the identification methods and in inhibiting bacterial growth, and methods for preparing and using such compositions.... Agent: Sughrue Mion, PLLC
20070020617 - Gel microdrops in genetic analysis: The invention provides methods of nucleic acid analysis. Such methods entail forming a population of gel microdrops encapsulating a population of biological entities, each entity comprising a nucleic acid, whereby at least some microdrops in the population each encapsulate a single entity. The population of gel microdrops is then contacted... Agent: Townsend And Townsend And Crew, LLP
20070020619 - Method for identifying motifs and/or combinations of motifs having a boolean state of predetermined mutation in a set of sequences and its applications: Methods for identifying a motif or a combination of motifs having a Boolean state of predetermined mutations in a set of sequences including a) aligning a set of sequences of ordered motifs represented by a single-character code, b) comparing a reference sequence with the set of sequences aligned in step... Agent: Ip Group Of Dla Piper US LLP
20070020616 - Parallel process for protein or virus separation from a sample: A sample is divided into a series of aliquots with the aliquots being subjected to at least two successive parallel separation steps in order to resolve protein or viral components thereof. The separation steps are performed not only on a sample but subsamples each containing a prelabeled tag to afford... Agent: Gifford, Krass, Groh, Sprinkle, Anderson & Citkowski, P.C.
20070020618 - Process to study changes in gene expression in t lymphocytes: Methods are disclosed to identify T lymphocyte genes that are differentially expressed upon exposure to a pathogen (viral or bacterial), immunogen, antigen, or in a sterile inflammatory disease, autoimmune disease, immunodeficiency disease, lymphocytic cancers, or graft versus host rejection. The method involves the preparation of a gene expression profile of... Agent: Morgan Lewis & Bockius LLP
20070020615 - Quantitative prediction method: The present invention concerns methods and systems for analysis of drug resistance in HIV-1. More specifically, the invention provides methods for predicting drug resistance by correlating genotypic information with phenotypic profiles. The methods allow the identification of primary and secondary resistance-associated mutations for new and existing drugs and for calculating... Agent: Philip S. Johnson Johnson & Johnson
20070020627 - Artificial transcription factors: Transcription regulating polypeptides that contain a plurality of DNA binding domains are provided. The polypeptides optionally contain one or more transcription regulating domains. Polynucleotides that encode the polypeptides and use of the polypeptides and polynucleotides are also provided.... Agent: The Scripps Research Institute
20070020649 - Chitosan capture of microorganisms for detection: Chitosan attached to a support surface is used to capture bacteria for detection purposes. Bacteria are captured with chitosan, lysed, and assayed using primers with sequences specific for nucleic acids of target species. The chitosan coated support serves as a capture device to collect or concentrate bacteria from a sample... Agent: Patent Group Attn: J. Kenneth Joung
20070020634 - Composition of orthogonal glutamyl-trna and aminoacyl-trna synthetase pairs and uses thereof: Compositions and methods of producing components of protein biosynthetic machinery that include glutamyl orthogonal tRNAs, glutamyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of glutamyl tRNAs/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.... Agent: Quine Intellectual Property Law Group, P.C.
20070020651 - Compositions and methods for the inference of pigmentation traits: The invention relates to methods for inferring a genetic pigmentation trait of a human subject from a nucleic acid sample or a polypeptide sample of the subject, and compositions for practicing such methods. The methods of the invention are based, in part, on the identification of single nucleotide polymorphisms (SNPs)... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper Rudnick Gray Cary US LLP
20070020662 - Computerized control of high-throughput experimental processing and digital analysis of comparative samples for a compound of interest: The present invention relates to computer-controlled automated high-throughput systems and/or computer-program products to design, prepare, process, and analyze a large number of samples having experimental formulations each containing a compound of interest formulated with differing component combinations and varying concentrations and component identities. The computer-controlled methods of the present invention... Agent: Workman Nydegger (f/k/a Workman Nydegger & Seeley)
20070020629 - Devices for component removal during blood collection, and uses thereof: The invention relates to a device and method for collecting blood whereby certain target components are isolated or removed from the blood sample at the time of collecting the blood, as well as methods for using such devices.... Agent: David W. Highet, Vp And ChiefIPCounsel Becton, Dickinson And Company
20070020666 - Differentially expressed genes in large granular lymphocyte leukemia: The subject invention concerns gene sequences and the use thereof as markers for large granular lymphocyte (LGL) leukemia. The gene sequences of the invention are differentially expressed in LGL. Another aspect of the invention pertains to therapeutic compositions directed to gene expression and gene products of differentially expressed genes in... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20070020653 - Dna polymerase: The present invention relates to DNA polymerases. In particular the invention relates to a method for the generation of DNA polymerases exhibiting a relaxed substrate specificity. Uses of mutant polymerases produced using the methods of the invention are also described.... Agent: Palmer & Dodge, LLP Kathleen M. Williams
20070020622 - Dna polymerases and mutants thereof: The present invention provides polypeptides having a nucleotide polymerase activity and method of enhancing polymerase activity. The polypeptides of the present invention may posses both a DNA-dependent DNA polymerase activity and an RNA-dependent DNA polymerase activity, i.e., a reverse transcriptase activity. The polypeptides of the present invention may be used... Agent: Sterne, Kessler, Goldstein & Fox PLLC
20070020626 - Evanescence-based multiplex sequencing method: The invention relates to a method and a device for evanescence-based multiplex sequencing of nucleic acid molecules immobilized on a support.... Agent: John W Mcilvaine
20070020660 - Expression profiles of peripheral blood mononuclear cells for inflammatory bowel diseases: The present invention is directed to the identification of PBMC- and IBD-associated biomarkers that may be used to diagnose inflammatory bowel disease, and optionally, distinguish between PBMCs isolated from a patient with Crohn's disease and PBMCs isolated from a patient with ulcerative colitis. The present invention is further directed to... Agent: Fitzpatrick Cella (wyeth)
20070020637 - Full-length cdna: Novel full-length cDNAs are provided. 2,495 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information... Agent: Foley And Lardner Suite 500
20070020659 - Generation of minicircle dna with physiological supercoiling: Methods for the production of supercoiled DNA minicircles and their use as substrates are described herein.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20070020621 - Genomic plant sequences and uses thereof: The present invention discloses rice genomic promoter sequences. The promoters are particularly suited for use in rice and other cereal crops. Methods of modifying, producing, and using the promoters are also disclosed. The invention further discloses compositions, transformed host cells, transgenic plants, and seeds containing the rice genomic promoter sequences,... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.
20070020631 - Identification of streptococcus penumoniae serotypes: The present invention relates to molecular methods of serotyping Streptococcus pneunoniae, as well as polynu-cleotides useful in such methods. These methods rely on analysing at least a portion of the nucleotide sequence between the 3′ end of the cpsA gene and the 5′ end of the cpsB gene, and/or analysing... Agent: Marshall, Gerstein & Borun LLP
20070020655 - Identification of tumors and tissues: The invention provides methods for the use of gene expression measurements to classify or identify tumors in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.... Agent: Townsend And Townsend And Crew, LLP
20070020639 - Isothermal locus specific amplification: Methods are provided for amplifying a template DNA strand using locus-specific primers and enzymes. The method involves denaturing template DNA and then annealing a primer to the single-stranded DNA strand. The primer is then extended using a DNA polymerase. The primer is cleaved downstream of the 3′ end of the... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.
20070020664 - Light emission modifiers and their uses in nucleic acid detection, amplification and analysis: The present invention relates to methods and reagents for modifying the emission of light from labeled nucleic acids for the purpose of real time detection, analysis, and quantitation of nucleic acid sequences, e.g., using singly labeled probes. These methods and reagents exploit advantageous properties of thiazine dyes and diazine dyes.... Agent: Quine Intellectual Property Law Group, P.C.
20070020648 - Measurement of mutation load using the p53 gene in human cells from paraffin embedded tissues: A method for determining mutation load in a somatic cell is determined by mutation analysis of the p53 gene. The p53 gene has been found to be a useful indicator of predisposition to spontaneous mutations or prior carcinogen exposure. Cells that contain mutated p53 tend to accumulate the mutant protein.... Agent: Cooper & Dunham, LLP
20070020671 - Method for detecting large mutations and duplications using control amplification comparisons to paralogous genes: Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular... Agent: O'melveny & Myers LLP
20070020644 - Method for detection and characterization of short nucleic acids: A method of detecting and characterizing a target short RNA is provided.... Agent: Patton Boggs LLP
20070020623 - Method for determining homeostasis of the skin: Described herein are processes and devices useful for the identification of genes differentially expressed in skin. Preferably, the processes and devices are useful for the in vitro determination of skin homeostasis. Also described is a combination having a plurality of genes differentially expressed in skin compared to other tissues. Biochips... Agent: Woodcock Washburn LLP
20070020636 - Method for early detection and monitoring of diseases by analysis of cell-surface-bound nucleic acids: This invention relates to noninvasive methods of early detection of different sicknesses, like precancerous state or early stages of cancer development, pathologies of pregnancy, and monitoring of efficacy of anticancer therapy. The method is based on cell-surface extra-cellular nucleic acids from human blood which is divided into plasma and cellular... Agent: Larson And Larson
20070020676 - Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group: A method for manufacturing a biochip and a biochip manufactured by the method are provided. In the biochip manufacturing method, a star-like polyethylene glycol derivative having an epoxy group at its terminal is reacted with a low molecular weight hydrophilic polymer to form a matrix, and a probe is covalently... Agent: Cantor Colburn, LLP
20070020661 - Method for obtaining purified rna from viable oocysts: The present invention describes novel oligonucleotides targeted to nucleic acid sequences derived from Crytosporidium organisms, and Crytosporidium parvum organisms in particular, which are useful for determining the presence of Cryptosporidium organisms in a test sample. The oligonucleotides of the present invention include hybridization assay probes, helper probes and amplification primers.... Agent: Gen Probe Incorporated
20070020632 - Method for selective inhibition of human n-myc gene in n-myc expressing tumors through antisense and antigen peptido-nucleic acids (pna): The present invention refers to sense and antisense peptido-nucleic acids (PNAs). The present invention further refers to the use of said PNAs for preparing drugs for treating genetic diseases.... Agent: Pearne & Gordon LLP
20070020645 - Method of analysis of samples by determination of a function of specific brightness: A method for characterizing samples having units, by monitoring fluctuating intensities of radiation emitted, scattered and/or reflected by said units in at least one measurement volume, the monitoring being performed by at least one detection means, said method comprising the steps: a) measuring in a repetitive mode a number of... Agent: Jacobson Holman PLLC
20070020668 - Method of manufacturing: A method of manufacturing items in parallel. Selected samples of items to be manufactured are subjected to additional steps in a manufacturing process. If such sample items meet the requisite quality control standard, remaining items are subjected to further manufacturing steps. If the sample items which have been further processed... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.
20070020667 - Methods and compositions for amplifying nucleic acids: Methods and compositions for amplifying nucleic acids are provided.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20070020652 - Methods and compositions for rna interference: The invention relates to improved methods of attenuating expression of a target gene in a eukaryotic cell with dsRNA, identifying nucleic acid sequences responsible for conferring a particular phenotype to a cell, alleviating pest infestation in plants, and altering gene expression in an undifferentiated stem cell or the differentiated progeny... Agent: Trask Britt
20070020654 - Methods and kits for preparing nucleic acid samples: The present invention provides methods for preparing nucleic acid samples. The methods of the present invention are particularly amenable for preparing samples that substantially represent the whole transcripts. In some aspects the methods include a step of reducing the amount of ribosomal RNA in a total RNA sample prior to... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.
20070020647 - Methods and reagents for treatment and diagnosis of age-related macular degeneration: The invention relates to Factor H gene polymorphisms and haplotypes associated with an elevated or a reduced risk of AMD. The invention provides methods and reagents for diagnosis and treatment of AMD.... Agent: Townsend And Townsend And Crew, LLP
20070020670 - Methods for detecting and confirming minimal disease: The present invention provides improved methods for detection of minimal disease. More specifically, the invention provides methods for combining cell sorting with clonality profiling to effectively lower sensitivity limits for disease detection and to provide independent confirmation of the tumor detection without the need for patient specific assay designs.... Agent: Seed Intellectual Property Law Group PLLC
20070020657 - Methods for detecting circulating tumor cells: Nucleic acids and methods for amplifying and detecting mutant BRAF sequences are provided herein. In particular, nucleic acids and methods for amplifying and detecting BRAF sequences that encode the V600E BRAF mutant are provided herein.... Agent: Fish & Richardson P.C.
20070020650 - Methods for detecting proteins: The invention provides methods for detecting antigens comprising forming an antibody/antigen complex in which the antibody is coupled to a polynucleotide having a known sequence. The sequence of the polynucleotide is identified in order to identify the antibody, thereby detecting the antigen.... Agent: Edwards & Angell, LLP
20070020678 - Methods for producing polypeptide-tagged collections and capture systems containing the tagged polypeptides: Methods for evenly distributing tags on collections of molecules are provided. Also provided are assay methods that employ the tagged collections.... Agent: Stephanie Seidman Fish & Richardson P.c
20070020630 - Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents: The present invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease. In particular, the invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease. The methods of the present invention provide a simple, sensitive assay for high-throughput screening... Agent: Jones Day
20070020673 - Model of autoimmune disease and methods for identifying agents against autoimmune disease: Homozygouse knock-out mice lacking the Aiolos gene are shown to exhibit multiple phenotypes in common with humans suffering from the autoimmune disease Systemic Lupus Erythematosus (SLE). When Aiolos −/− mice are crossed with homozygous knock out mice lacking the OBF-1 transcription factor gene, resultant double knock out mice lack all... Agent: Novartis Corporate Intellectual Property
20070020675 - Modulation of endothelial lipase expression: Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and for diagnosis and treatment of disease associated with expression of endothelial lipase are provided.... Agent: Knobbe, Martens, Olson & Bear, LLP
20070020679 - Modulation of hif1alpha and hif2alpha expression: Compounds, compositions and methods are provided for modulating the expression of HIF1α and/or HIF2α. The compositions comprise oligonucleotides, targeted to nucleic acid encoding HIF1α and HIF2α. Methods of using these compounds for modulation of HIF1α and/or HIF2α expression and for diagnosis and treatment of disease associated with expression of HIF1α... Agent: Knobbe, Martens, Olson & Bear, LLP
20070020640 - Molecular encoding of nucleic acid templates for pcr and other forms of sequence analysis: In a first aspect, the present invention provides methods for authenticating a nucleic acid molecule and its sequence with a molecular barcode and batch-stamp. In another aspect, the present invention provides methods for authenticating a nucleic acid amplification product. In a further aspect, the present invention provides compositions for encoding... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20070020674 - Novel gene defective in apeced and its use: The present invention relates to a method for the diagnosis of a disease related to immune maturation and regulation of immune response towards self and nonself, comprising the steps of detecting in a biological specimen the presence of a DNA sequence comprising the sequence of SEQ ID NO:1.... Agent: Ladas & Parry
20070020624 - Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Pseudomonas aeruginosa that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Nina L. Pearlmutter Genome Therapeutics Corporation
20070020680 - Nucleic acid marker ladder for estimating mass: The invention relates to a nucleic acid marker ladder which is a restriction endonuclease digest, wherein a nucleic acid restriction endonuclease digest is a collection of nucleic acid fragments resulting from complete digestion of one or more nucleic acids by one or more restriction endonucleases; the restriction endonuclease digest contains... Agent: Invitrogen Corporation C/o Intellevate
20070020672 - Nucleic acid melting analysis with saturation dyes: Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye... Agent: Ice Miller LLP
20070020635 - Nucleotides for prevention and treatment of bacterial and fungal pathologies: A selectively inducible, single-stranded DNA (ssDNA) expression library, a method for constructing a ssDNA expression library, a method for screening ssDNA using the expression library, and a method for identifying ssDNA molecules that alter expression of bacterial and fungal gene(s) related to cell growth and toxin production and secretion. The... Agent: Osha Liang L.L.P.
20070020643 - Photocleavable bioreactive agents: This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise agents... Agent: Medlen & Carroll, LLP
20070020658 - Polymorphisms in fatty acid binding protein 4 (\"fabp4\") gene and their associations with measures of marbling and subcutaneous fat depth in beef cattle: The physiological regulation of intake, growth and energy partitioning in animals is under the control of multiple genes, which may be important candidates for unraveling the genetic variation in economically relevant traits in beef production. The present invention relates to the identification of single nucleotide polymorphisms (SNPs) within the bovine... Agent: Frommer Lawrence & Haug
20070020665 - Probes and methods for hepatitis c virus typing using single probe analysis: This invention provides compositions and methods for HCV typing, e.g., genotyping and/or subtyping. The compositions and methods of the invention can be used to assign an HCV isolate to one of at least five HCV genotypes (for example, selected from genotypes 1, 2, 3, 4, 5 or 6), or assign... Agent: Quine Intellectual Property Law Group, P.C.
20070020663 - Reaction monitoring systems: The present invention provides an apparatus for simultaneously monitoring an array of reaction sites for light indicating that a reaction is taking place at a particula site comprising a charge-coupled device (CCD) arranged so that in use the light from a particular reaction site will impinge upon a particular predetermined... Agent: Dorsey & Whitney LLP Intellectual Property Department
20070020641 - Reagentless, reusable, bioelectronic detectors employing aptamers: A reagentless, reusable bioelectronic DNA, or other oligonucleotide sequence sensor is disclosed. The sensor includes an oligonucleotide (aptamer) probe tagged with a electroactive, redoxable moiety, self-assembled on or near an electrode. This surface-confined oligonucleotide (aptamer) probe structure undergoes hybridization-induced conformational change in the presence of the target which changes the... Agent: Foley & Lardner LLP
20070020669 - Regulation analysis by cis reactivity, racr: Methods of detecting affinity interactions between at least two molecules of interest are provided. The method comprises: a. forming a plurality of interactors by coupling each molecule of interest with at least one nucleic acid moiety comprising an identification sequence element and at an association element; b. promoting an association... Agent: Dinsmore & Shohl, LLP
20070020625 - Sequence of the photorhabdus luminescens strain tt01 genome and uses: The present invention relates to the genomic sequence and to nucleotide sequences encoding polypeptides of Photorhabdus luminescens. The present invention further relates to polypeptides involved in operons involved in the biosynthesis of antibiotics or toxins, as well as polypeptides with activity of the antibiotic or toxin. Uses of the aforementioned... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.
20070020656 - Snapback oligonucleotide probe: The invention relates to compositions and methods for detection of specific nucleic acid sequences during an amplification reaction. The invention further relates to a kit format of said compositions for detection of nucleic acid sequences. The Snapback oligonucleotide probes of the invention comprise a target binding sequence, a hairpin forming... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str
20070020642 - Structural interaction fingerprint: Disclosed is a method for representing and analyzing 3D target molecule-ligand intermolecular interactions. The method generates structural interaction fingerprints (SIFts) that convert three-dimensional structural interaction information into linear information strings that contains a plurality of information blocks; each of which in turn containing a plurality of information units. By assigning... Agent: Steptoe & Johnson LLP
20070020628 - Tkts as mondifiers of the beta-catenin pathway and methods of use: Human TKT genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of TKT are provided.... Agent: Patent Dept Exelixis, Inc.
20070020633 - Treatment of nucleic acid: The invention provides methods for treating nucleic acid, particularly nucleic acid that is methylated. In one embodiment, the method can include the steps of (a) providing a denaturing environment to a nucleic acid sample; (b) reacting the nucleic acid sample with a bisulphite reagent and incubating the reaction so as... Agent: Knobbe Martens Olson & Bear LLP
20070020646 - Use of id4 for diagnosis and treatment of cancer: Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis. Further, aberrant hypermethylation of ID4 gene promoter region increases risk of metastasis in colorectal and breast cancer.... Agent: Hogan & Hartson L.L.P.
20070020638 - Variants of the adam 12 gene: The invention relates to variants of the ADAM12 gene and the role these variants have to play in the diagnosis and treatment of a number of conditions including cancer, disorders of myogenesis, adipogenesis, cardiac hypertrophy and Alzheimer's disease, and in particular, Late Onset Alzheimer's Disease.... Agent: King & Schickli, PLLC
20070020695 - Compositions and methods for detecting stress-inducible proteins: Compositions and methods for detection of the stress-inducible Hsp70B′ protein are disclosed. These include antibodies directed against particular amino acid regions of Hsp70B′ and various peptides corresponding, or antigenically equivalent, to the regions. The ability to generate anti-Hsp70B′ antibodies to defined epitopes permits a variety of in vitro and in... Agent: Fish & Richardson PC
20070020686 - Db, the receptor for leptin, nucleic acids encoding the receptor, and uses thereof: The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form... Agent: Klauber & Jackson
20070020687 - Detection of rho proteins: The present invention provides methods of detecting activated Rho GTPase proteins by contacting a solid support with a sample comprising an activated Rho GTPase protein. The solid support is linked to an activated Rho GTPase binding peptide. The activated Rho GTPase protein remains associated with the solid support during the... Agent: Cozen O' Connor, P.C.
20070020693 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati
20070020681 - Hydrolytic substrates for an analyte-dependent enzyme activation system: wherein Y is a moiety capable of being cleaved by a hydrolytic enzyme; L is a detectable label; X is a linking group; Z is a halogen; and R is hydrogen, an alkyl, or a halogen. Compounds of this general formula can be used as substrates in an analyte-dependent enzyme... Agent: Gifford, Krass, Groh, Sprinkle, Anderson & Citkowski, P.C.
20070020689 - Label-free high throughput biomolecular screening system and method: A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a... Agent: Corning Incorporated
20070020688 - Measurement method using biosensor: It is an object of the present invention to provide a method for carrying out on a same biosensor both of the measurement of the amount of a physiologically active substance immobilized on a biosensor substrate and the measurement of the biological activity of the above physiologically active substance, thereby... Agent: Sughrue Mion, PLLC
20070020690 - Method for site-specific protein modifications: A method for site-specific modification of protein molecules includes providing a protein molecule having at least first and second non-terminal Cys residues at respective first and second sites within the protein molecule, providing a blocking molecule that is suitable to interact with the protein molecule to selectively block the second... Agent: Venable LLP
20070020692 - Methods of assaying connective tissue growth factor: The present invention relates to methods of detection and quantitation of connective tissue growth factor (CTGF), and diagnosis and detection of various CTGF-associated diseases and disorders.... Agent: Fibrogen, Inc. Intellectual Property Department
20070020683 - Monoclonal antibodies for detection of urinary trypsin inhibitors: Certain monoclonal antibodies are able to detect urinary trypsin inhibitors (UTIs) that are characteristic of disease in humans. In particular, the UTIs include AMBK, Bikunin, Uristatin, Uristatin-1, Uristatin-2, as defined herein, also including the fragments and aggregates thereof.... Agent: Kelley Drye & Warren LLP
20070020691 - Multiplex determination of lipid specific binding moieties: To perform large-scale multiplex analysis of lipid-specific binding, lipid microarrays were developed. Lipids identified as disease associated, or analogs there, can be tolerogenic to patients suffering from autoimmune disease. Lipid array analysis has revealed anti-lipid antibodies in patients with immune disorders, and may contribute to the pathogenesis of disease.... Agent: Bozicevic, Field & Francis LLP
20070020694 - Prodrug compounds with isoleucine: The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by an enzyme associated with the target cell. Methods of... Agent: Lahive & Cockfield, LLP
20070020685 - Secretion of antibodies without signal peptides from bacteria: The present invention is directed generally to compositions and methods for obtaining secretion of antibodies or antigen-binding antibody fragments from prokaryotes without the need for a signal peptide through making use of mutant host strains with altered secretory properties. In particular, the invention provides host cells and methods for obtaining... Agent: Mcdermott Will & Emery LLP
20070020684 - Structure of a glucocorticoid receptor ligand binding domain comprising an expanded binding pocket and methods employing same: A solved three-dimensional crystal structure of a glucocorticord receptor (GR) α ligand binding domain polypeptide is disclosed, in the form of a crystalline glucocorticord receptor α ligand binding domain polypeptide in complex with the ligand fluticasone propionate (FP) and a peptide derived from the co-activator TIF2. The GR/FP/TIF2 structure includes... Agent: David J Levy, Corporate Intellectual Property Glaxosmithkline
20070020682 - Use of prion conversion modulating agents: The use of Apolipoprotein B, Apolipoprotein E, fragments and mimetics thereof is provided for diagnostic, detection, prognostic and therapeutic applications In prion diseases. More specifically, the invention provides the use of Apolipoprotein B or fragments thereof for modulating or identifying modulators of the prion protein replication which are implicated in... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.
20070020696 - Appl proteins as rab5 effectors: The present invention relates to an in vivo-assay to screen for anti-proliferative drugs, the assay comprising the steps of: (a) contacting cells of a primary cell culture or of an established cell line with a candidate substance, (b) subsequently or concomitantly with a candidate substance, contacting the cells with a... Agent: Fulbright & Jaworski L.L.P.
20070020698 - Igf binding proteins: IGFBP-3 fusion proteins are provided that are useful, for example, in cell-based assays, as IGF antagonists, and in mapping IGF-I and IGF-II binding sites on other molecules such as wild-type IGFBP-3 and IGF agonist peptides identified by phage display. Methods for making such fusion proteins are also provided.... Agent: Heller Ehrman LLP
20070020697 - Virtual flow cytometry on immunostained tissue-tissue cytometer: The invention provides an automated method of single cell image analysis which determines cell population statistic, applicable in the field of pathology, disease or cancer diagnosis, in a greatly improved manner over manual or prior art scoring techniques. By combining the scientific advantages of computerized automation and the invented method,... Agent: Hernani Cualing
20070020704 - Diaryl ureas with kinase inhibiting activity: The present invention provides methods of using aryl ureas to treat diseases and conditions associated with signal transduction pathways comprising at least one of raf, VEGFR, PDGFR, p38 and/or FLT-3. The present invention also provides compositions and methods for identifying conditions and diseases which can be modulated with compounds of... Agent: Millen, White, Zelano & Branigan, P.C.
20070020703 - Use of compositions comprising a soluble form of hla-g in the treatment of blood diseases: The invention relates to the use of compositions comprising a soluble form of HLA-G in the treatment of blood and circulatory system diseases (anemias and ischaemias).... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.
20070020710 - Antibodies that spefically recognize inactive psa, and uses thereof: An immunoassay for the quantitative determination of inactive, non-zymogen, free PSA in a biological sample taken from an individual, including contacting the biological sample with a reagent, where the reagent comprises an antibody or antibody fragments that bind specifically to inactive, non-zymogen, free PSA, the antibody being a purified polyclonal... Agent: Oliff & Berridge, PLC
20070020709 - Igf binding proteins: IGFBP-3 fusion proteins are provided that are useful, for example, in cell-based assays, as IGF antagonists, and in mapping IGF-I and IGF-II binding sites on other molecules such as wild-type IGFBP-3 and IGF agonist peptides identified by phage display. Methods for making such fusion proteins are also provided.... Agent: Heller Ehrman LLP
20070020705 - Method for prognostic evaluation of carcinoma using anti-p-lap antibody: The present invention provides a reagent for prognostic evaluation of carcinoma patients, comprising an anti-P-LAP antibody as an active ingredient. Also, the present invention provides a method for determination of P-LAP which is a prognostic factor in carcinoma patients comprising (a) a step of contacting carcinoma tissues obtained from carcinoma... Agent: Drinker Biddle & Reath (dc)
20070020708 - Paad domain-containing polypeptides, encoding nucleic acids, and methods of use: The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NACHT domains and ARED domains, encoded polypeptides, and antibodies. Also provided are methods of identifying polypeptides and agents that associate with a PAAD-domain containing polypeptide or fragment thereof, or that... Agent: Mcdermott, Will & Emery
20070020707 - Tissue inhibitor of matrix metalloproteinases type-1 (timp-1) as a cancer marker: The present invention describes a method for determining whether an individual is likely to have cancer by determining a parameter representing the TIMP-1 concentration in body fluid samples from the individual.... Agent: Roberts, Mlotkowski & Hobbes
20070020706 - Truncated proteins as cancer markers: Methods/reagents for detecting and/or treating cancers or potential cancers are disclosed. In one embodiment, methods and reagents for detecting truncated forms of P2X7 protein in cells are described. In one embodiment, methods and reagents for increasing the amount and/or activity of full-length P2X7 in cells are described. In one embodiment,... Agent: Medlen & Carroll, LLP
20070020711 - Fungal antigen immunoassay: The present disclosure relates to methods for detecting a fungal antigen in a physiological specimen. The present invention includes methods and materials for testing for antigens associated with endemic mycoses as well as quantitative analysis of the test results.... Agent: Indianapolis Office 27879 Brinks Hofer Gilson & Lione
20070020712 - Use of ylqf, yqeg, yybq, and ysxc, essential bacterial genes and polypeptides: Disclosed are genes found in Streptococcus pneumoniae that are essential for survival for a wide range of bacteria. These genes are termed “S-ylqF,” “S-yqeG,” “S-yybQ,” “S-yerL,” and “S-ysxC.” These genes and the polypeptides that they encode, as well as homologs and orthologs thereof can be used to identify antibacterial agents... Agent: Fish & Richardson PC
20070020699 - Lateral flow assay and device using magnetic particles: A complex including magnetic particle bound to a metal colloid. The complex may be part of a reagent for use in a method for determining analytes. The reagent may include a binding partner specific for an analyte. The reagent may further include a first label that is distinguishable from a... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20070020700 - Lateral flow assay and device using magnetic particles: A complex including magnetic particle bound to a metal colloid. The complex may be part of a reagent for use in a method for determining analytes. The reagent may include a binding partner specific for an analyte. The reagent may further include a first label that is distinguishable from a... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20070020701 - Magnetic resonance system and method to detect and confirm analytes: A system and method are provided to detect target analytes based on magnetic resonance measurements. Magnetic structures produce distinct magnetic field regions having a size comparable to the analyte. When the analyte is bound in those regions, magnetic resonance signals from the sample are changed, leading to detection of the... Agent: Procopio, Cory, Hargreaves & Savitch LLP
20070020713 - Antibodies to the fuel oxygenate mtbe and use thereof in immunoassays: Immunoassay of methyl tert-butyl ether (MTBE) and related fuel oxygenates and their breakdown products is performed using a monoclonal antibody produced using a hapten with a CH3—O—C(CH3)2—CH2-moiety, preferably CH3—O—C(CH3)2—(CH2)3—CH(CH3)—CH2—CHO conjugated to a carrier protein.... Agent: Stites & Harbison PLLC
20070020714 - Fluorescent indicator proteins having increased signal intensity to concentration of sugars and use thereof: A protein biosensor having increased signal intensity to sugar concentration and the use thereof. A fluorescent indicator protein is described, in which fluorescent proteins of different emission ranges are fused to both ends of a binding protein undergoing a confornational change due to binding of sugars, such that a change... Agent: Intellectual Property / Technology Law
20070020716 - Coronary endothelial dysfunction: This document provides methods and materials related to assessing coronary endothelial dysfunction (CED) conditions as well as methods and materials related to treating coronary conditions. For example, methods and materials for determining whether or not a mammal has CED by determining whether or not a sample from the mammal contains... Agent: Fish & Richardson P.C.
20070020715 - Novel fluorogenic substrates for beta-lactamase gene expression: in which W is a hydrogen, alkyl, substituted heteroalkyl, aryl, a heteroaryl, substituted heteroaryl or a CN; and, S is an integer from 0 to 5; W′ and W″ are independently hydrogen, alkyl, substituted heteroalkyl, aryl, substituted heteroaryl, (═O) or OR10; wherein R10 is hydrogen, substituted alkyl, heteroalkyl, substituted heteroalkyl,... Agent: Quine Intellectual Property Law Group, P.C.
20070020717 - Methods and compositions for modulating cox: The invention provides an assay for determining whether a test agent is a COX modulator. In general terms, the assay includes: determining whether a test agent modulates binding of a PDZ-containing polypeptide to a COX PL-containing polypeptide. The PDZ-containing polypeptide may contain the PDZ domain of PDZ domain of MAGI1,... Agent: Townsend And Townsend And Crew, LLP
20070020718 - Method for quantitative analysis of proline hydroxylation-induced interactions between hif-1 and vbc protein complex using fluorescence polarization: The present invention relates to a method for analyzing the interaction between HIF-1 peptide and VBC protein using fluorescence polarization, more precisely, a method for quantitative analysis of formation of HIF-1-VBC protein complex which is composed of the steps of 1) preparing a fluorescent probe by attaching a fluorescein to... Agent: Jhk Law
20070020721 - Blood analyzing method and blood analyzer: A blood analyzing method is described that includes steps of: preparing a measurement sample by hemolyzing red blood cells in a blood specimen, the measurement sample containing particles; irradiating a light on the measurement sample to detect two or more types of optical information reflecting characters of the particles in... Agent: Brinks Hofer Gilson & Lione
20070020720 - Method for the detection and/or identification of bacteria present in a sample: f. the temperature T1 is higher than the temperature T2 such that a defined volume of culture medium is transferred from the first container to the second container, g. the presence or absence of bacteria is determined and/or the bacteria are identified within the detection system.... Agent: Oliff & Berridge, PLC
20070020719 - Selective culture medium for the isolation and/or detection of species in the streptococcus genus: The medium includes specific ratios of mixtures of nutritive bases, rich in compounds of protein origin (polypeptides, peptides, proteoses, and aminoacids) and vitamins, which facilitate an abundant growth of the target species. In addition, the inclusion of the blood enzymatic hydrolyzate, guarantees the presence in the medium of blood-derived substances... Agent: Lackenbach Siegel, LLP
20070020724 - 94 human secreted proteins: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing... Agent: Human Genome Sciences Inc Intellectual Property Dept.
20070020723 - Ceramide kinase-like proteins: A ceramide kinase like protein encoded by a polynucleotide of SEQ ID NO: 1 to SEQ ID NO: 9 and its use.... Agent: Novartis Corporate Intellectual Property
20070020727 - Exo-specific amylase polypeptides, nucleic acids encoding those polypeptides and uses thereof: This invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exospecifity.... Agent: Genencor International, Inc.
20070020732 - Mast cell-specific signal transducer and cdna thereof: The present invention provides a signal transducer specifically expressed in mouse mast cells that has the amino acid sequence of SEQ ID No. 2, a signal transducer specifically expressed in human mast cells that has the amino acid sequence of SEQ ID No. 4, polynucleotides encoding these proteins, an expression... Agent: Wenderoth, Lind & Ponack, L.L.P.
20070020730 - Method for overexpression of zwitterionic polysaccharides: The present invention is directed to methods for producing and selecting novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the novel mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular... Agent: Wolf Greenfield & Sacks, PC
20070020728 - Muteins of apolipoprotein d: A method of generating a mutein of human apolipoprotein D having detectable binding affinity to a given non-natural ligand of apolipoprotein D is disclosed, which comprises the steps of subjecting apolipoprotein D to mutagenesis at the sequence positions 34 to 38, 60, 62 to 66, 68, 89 to 93, 115,... Agent: Foley And Lardner LLP Suite 500
20070020729 - Novel collectin: Novel collectin related molecules i.e., a novel collectin gene comprising a nucleotide sequence set out in SEQ ID NO: 1, and a novel collectin comprising an amino acid sequence set out in SEQ ID NO: 2, which are expected to exhibit anti-bacterial, anti-viral activity or the like especially in human... Agent: Marshall, Gerstein & Borun LLP
20070020726 - Novel glutaminase, its gene and a method of producing it: Glutaminase is purified from an Aspergillus oryzae, its partial amino acid sequence is determined, a partial sequence of glutaminase gene is obtained by PCR based on the obtained information, and DNA fragments containing glutaminase gene from Aspergillus oryzae genomic library and cDNA library, and Aspergillus nidulans genomic library by hybridization... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.
20070020725 - Prokaryotically produced antibodies and uses thereof: The present invention provides methods and compositions for improved expression and production of recombinant antibodies in prokaryotic expression systems. Particularly contemplated are prokaryotic expression and production of full length aglycosylated antibodies. The antibody products of the invention can be used in various aspects of biological research, diagnosis and medical treatment.... Agent: Merchant & Gould PC
20070020722 - Telomere elongation: The present invention relates, in general, to telomeres, and, in particular, to a method or effecting telomere elongation in mammalian cells. The invention further relates to a protein suitable for use in such a method and to nucleic acid sequences encoding same.... Agent: Nixon & Vanderhye, PC
20070020731 - Thermostable amylase polypeptides, nucliec acids encoding those polypeptides and uses thereof: This is invention relates to amylase polypeptides, and nucleic acids encoding the polpypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered thermostability.... Agent: Genencor International, Inc.
20070020733 - Compositions and methods for detection of ehrlichia canis and ehrlichia chaffeensis antibodies: The invention provides methods and compositions for the detection of Ehrlichia canis and Ehrlichia chaffeensis antibodies and antibody fragments.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20070020734 - Interferon-alpha polypeptides and conjugates: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the... Agent: Maxygen, Inc. Intellectual Property Department
20070020735 - Il-17 homologous polypeptides and therapeutic uses thereof: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide... Agent: Sidley Austin LLP Attn: Dc Patent Docketing
20070020736 - Efficient production of oligosaccharides using metabolically engineered microorganisms: The present invention relates to the enzymatic synthesis of oligosaccharides, particularly, sialylated oligosaccharides comprising the carbohydrate moeities of the gangliosides GM3, GD3, and GT3.... Agent: Foley And Lardner LLP Suite 500
20070020737 - Hyaluronan synthases and methods of making and using same: A functionally active hyaluronan synthase having at least one modified amino acid residue therein as compared to a corresponding functionally active native hyaluronan synthase such that the functionally active hyaluronan synthase has an altered enzymatic activity as compared to the corresponding functionally active native hyaluronan synthase is disclosed. The altered... Agent: Dunlap, Codding & Rogers P.C.
20070020740 - Blocking sporulation by inhibiting spoiie: We have shown that the control of solventogenesis and sporulation can be genetically uncoupled in C. acetobutylicum. In strain 824(pASspo), the absence of SpoIIE causes sporulation to be blocked at stage II. The cell remains in a vegetative state, and this allows solvent production to proceed for longer and for... Agent: Baker & Mckenzie LLP
20070020739 - Enzyme gene participating in the synthesis of polyester and process for producing polyester using the same: This invention relates to a method of producing polyesters resulting from homopolymerization or copolymerization of a 3-hydroxyalkanoic acid(s) and having biodegradability and good physical properties using yeasts as hosts. By constructing at least one enzyme gene involved in polyester synthesis by adding a DNA coding a peroxisome-targeting signal, introducing an... Agent: John C Altmiller Kenyon & Kenyon
20070020741 - Process for preparing enantiomer-enriched alpha-hydroxycarboxylic acids and amides: The present invention describes an enzymatic process for preparing enantiomer-enriched α-hydroxycarboxylic acids and amides which comprises, in one step, the conversion of a carbonyl compound to the corresponding acid/amides via the intermediate stage of a cyanohydrin. The invention also provides a reaction system operating in such a way and a... Agent: Fitch, Even, Tabin & Flannery
20070020742 - Glycerol-3-phosphate phosphatase and glycerol-3-phosphate dehydrogenase from candida albicans, genes encoding the same, vector and host cell containing the genes, and method for producing glycerol using the host cell: Provided are a polypeptide having glycerol-3-phosphate dehydrogenase activity and a 80% or more homology to an amino acid sequence as set forth in SEQ ID NO: 1 and a polypeptide having glycerol-3-phosphate phosphatase activity and a 80% or more homology to an amino acid sequence as set forth in SEQ... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.
20070020744 - Enzyme compositions that enhance the flavor of food and beverages: The invention provides enzyme compositions that are useful for enhancing the nutritional value and/or flavor of food and beverage products. The invention also provides a process for producing such food and beverage products that have enhanced nutritional and/or flavor profiles.... Agent: Foley And Lardner LLP Suite 500
20070020743 - Undecaprenyl pyrophosphate synthase (upps)enzyme and methods of use: A novel Streptococcus pneumoniae UPPS native crystalline structure and a novel Streptococcus pneumoniae UPPS complex with the substrates FPP and IPP are identified.... Agent: David J Levy, Corporate Intellectual Property Glaxosmithkline
20070020745 - Method for crystallizing human gsk3 and novel crystal structure thereof: The invention provides the three-dimensional structure of a construct of human glycogen synthase kinase 3 (GSK3); crystals of a construct of human glycogen synthase kinase 3-β (GSK3-β) containing the protein's catalytic kinase domain; a method for crystallizing the protein construct to provide a GSK3 crystal sufficient for structure determination; and... Agent: Chiron Corporation Intellectual Property - R440
20070020746 - Staphylococcus aureus polynucleotides and sequences: The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media,... Agent: Human Genome Sciences Inc Intellectual Property Dept.
20070020747 - Composition for eliminating ethidium bromide and use thereof: The present invention is related to a composition and a method for eliminating ethidium bromide.... Agent: Harness, Dickey & Pierce, P.L.C
20070020748 - Apparatus for screening proptein crystallization conditions: The present invention is intended to provide an apparatus for screening protein crystallization conditions that can screen protein crystallization conditions efficiently by the vapor diffusion method using the sitting drop technique. In order to achieve the above-mentioned object, in an apparatus for screening protein crystallization conditions that screens protein crystallization... Agent: Hamre, Schumann, Mueller & Larson P.C.
20070020749 - Materials and methods for creating imaging layers: The present invention provides patterned features of dimensions of less than 50 nm on a substrate. According to various embodiments, the features may be “Manhattan” style structures, have high aspect ratios, and/or have atomically smooth surfaces. The patterned features are made from polymer brushes grafted to a substrate. In some... Agent: Beyer Weaver & Thomas, LLP
20070020750 - Culture chamber, culture apparatus and liquid supplying method for cell or tissue cultivation: A culture chamber which cultivates a culture object by using a culture liquid has a culture space part which houses the culture object together with the culture liquid, an introducing part (an introducing port) which introduces the culture liquid into the culture space part, a discharging part (a discharging port)... Agent: Connolly Bove Lodge & Hutz LLP
20070020751 - Bioreactor, in particular for nmr spectroscopy: A description is given of a bioreactor (1), in particular for NMR spectroscopy, comprising a container (7) capable of containing a cell culture, a first inlet line (6) for the inward flow of a culture medium to the inside of the container and a second outlet line (9, 10) for... Agent: James C. Eaves Jr. Greenebaum Doll & Mcdonald PLLC
20070020752 - Cell culturing device and system: Devices, systems, and methods for culturing cells and providing a contaminant-free connection are disclosed. A cell culture device comprises a container having first and second side walls wherein the first and second side walls are gas permeable, the device further comprising a female connector and a male connector. At least... Agent: Leydig Voit & Mayer, Ltd
20070020753 - Condensation reducing/eliminating container: The present invention provides methods for reducing the amount of condensation in a container by providing a container comprising a lid, wherein the amount of condensation in the container is reduced by: increasing all or a portion of the thickness of the lid; insulating the lid; or combinations thereof. The... Agent: Dinsmore & Shohl LLP
20070020754 - Cell handling device, human tissue regeneration composition, and human tissue regeneration method: The main objects of the present invention, which relates to regenerative medical treatments, are to enable (i) storage and conveyance of harvested or cultured cells without contamination occuring (ii) simple injection of the cells into a living body. To achieve these objects, cells harvested from a living body, or cells... Agent: Wenderoth, Lind & Ponack, L.L.P.
20070020756 - Methods of culturing, storing, and inducing differentiation in cells, instrument for use in the methods, method of using the instrument, and medical biomaterial: The present invention provides methods of culturing or storing cells for a prolonged period while suppressing a loss of functions of the cells during storage, by applying centrifugal force or pressure such as hydraulic pressure to the cells to form compact bodies, particularly aggregates, in which a state of high... Agent: Leydig Voit & Mayer, Ltd
20070020755 - Stage specific follicle maturation systems: Improved three dimensional culture systems for the maturation and development of individual follicles and oocytes. The present invention optimizes preantral two-layer secondary follicle growth and maturation, preantral multilayer secondary follicle growth and maturation, and oocyte developmental competence by encapsulating individual follicles into polymeric hydrogel beads having optimal concentrations of polysaccharide.... Agent: Todd S. Parkhurst Holland & Knight LLP
20070020757 - Methods for expansion and analysis of cultured hematopoietic stem cells: Methods and kits for propagating hematopoietic stem cells are provided. The methods comprise culturing cells in medium comprising one or more angiopoietin-like proteins, under conditions sufficient for expansion of HSCs. Angiopoietin-like proteins include angiopoietin-like protein 2, angiopoietin-like protein 3, angiopoietin-like protein 4, angiopoietin-like protein 5, angiopoietin-like protein 7, and microfibrillar-associated... Agent: Proskauer Rose LLP
20070020758 - Method for the isolation and expansion of cardiac stem cells from biopsy: Method for the isolation, expansion and preservation of cardiac stem cells from human or animal tissue biopsy samples to be employed in cell transplantation and functional repair of the myocardium or other organs. Cells may also be used in gene therapy for treating genetic cardiomyopathies, for treating ischemic heart diseases... Agent: Albert Wai-kit Chan Law Offices Of Albert Wai-kit Chan
20070020759 - Therapeutic reprogramming of germ line stem cells: Pluripotent therapeutically programmed cells and methods for making such cells are provided. The pluripotent therapeutically programmed cells are post-natal stem cells which have been matured such that they represent either a more differentiated state or a less differentiated state after contact with stimulatory factors. The pluripotent therapeutically reprogrammed cells are... Agent: Preston Gates & Ellis LLP
20070020760 - Medium supplement and animal cell culture medium: An object of the present invention is to provide a medium supplement for animal cell culture and an animal cell culture medium. The present invention relates to a medium supplement for animal cell culture comprising sericin or a sericin derivative and an animal cell culture medium comprising at least said... Agent: Ladas & Parry LLP
20070020761 - Solid surface for biomolecule delivery and high-throughput assay: The present invention is related to a method for introducing biomolecules, such as nucleic acids, into cells by culturing cells on a solid surface which is coated with a transfection reagents and biomolecules.... Agent: Knobbe Martens Olson & Bear LLP01/18/2007 > 152 patent applications in 41 patent subcategories. USPTO class patent listing
20070015131 - Extracorporeal organ conservation: Storage system for extracorporeal storage of organs. The storage system artificially maintains or regenerates the vital functions of organs, including limbs and tissue lobes. The storage system comprises an organ perfusion chamber filled with dialysate as a storage fluid and equipped with a temperature control device that maintains the temperature... Agent: Bohan, Mathers & Associates, LLC
20070015136 - Controlling dendritic cell maturation state in the lymphoid tissue equivalent of an artificial immune system: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates... Agent: Merchant & Gould PC
20070015133 - Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein: The invention relates to the field of aqueous solutions comprising a protein. More specifically, the invention relates to the detection and/or removal of conformationally altered proteins and/or peptides comprising a cross-β structure from an aqueous solution comprising a protein. The invention provides methods for detecting and/or removing proteins and/or peptides... Agent: Trask Britt
20070015135 - Methods and computer systems for analyzing high-throughput assays: The present invention provides methods and computer programs for detecting variations in measurements of a biological variable, e.g., variations in cell viability, under different conditions, e.g., with or without treatment of a drug, under the treatments of different drugs, or under different environmental conditions. The methods and programs of the... Agent: Jones Day
20070015138 - Methods for identifying agents and conditions that modulate neurogenesis: Methods and tools for identifying agents and conditions that modulate neurogenesis are disclosed. The disclosure also relates to methods and tools for identifying populations of neural stem cells suitable for transplantation.... Agent: Townsend And Townsend And Crew, LLP
20070015137 - Microfluid device and method of producing diffusively built gradients: A microfluid device for producing diffusively built gradients comprising a bottom plate and a cover plate, wherein the cover plate has recesses and is connected to the bottom plate in a liquid-tight manner so that the recesses form at least two reservoirs and one observation chamber, which connects the reservoir,... Agent: Ip Strategies
20070015134 - Quantitative stabilized cell reference control products and methods: The invention relates to quantitative stabilized cell reference control products, their methods of manufacture, and their methods of use. Receptors, antigens, and ligands associated with stabilized cells may be quantitated by the methods of the present invention. Those quantitated stabilized cells may then be used to determine the receptor, antigen,... Agent: Sterne Kessler Goldstein & Fox, P.l.l.c.
20070015132 - System and methods for measuring at least one metabolic rate of a plurality of cells: A system and methods for calculating at least one unknown metabolic flux of a plurality of cells. In one embodiment, the method includes the steps of constructing a metabolic network having a plurality of reaction components, the reaction components representing at least glycolysis, reduction of pyruvate to lactate, TCA cycle,... Agent: Morris Manning Martin LLP
20070015139 - Biological reagents and methods to verify the efficiency of sample preparation and nucleic acid amplification and/or detection: This invention relates to reagent comprising: any one of cells, viral particles, organelles, parasites, cells comprising organelles, cells comprising viral particles, cells comprising parasites, cells comprising bacterial cells and any combination thereof, the cells, viral particles, organelles or parasites comprising at least one nucleic acid sequence serving as an internal... Agent: Oliff & Berridge, PLC
20070015142 - Detection of hiv-1 by nucleic acid amplification: Nucleic acid sequences and methods for detecting HIV-1 nucleic acid (LTR and pol sequences) in biological samples by detecting amplified nucleic acids are disclosed. Kits comprising nucleic acid oligomers for amplifying HIV-1 nucleic acid present in a biological sample and detecting the amplified nucleic acid are disclosed.... Agent: Gen Probe Incorporated
20070015140 - Method of examining specimen and specimen container to be used in the examination method: A method of immunologically examining a specimen which comprises attaching a cap having a filter impregnated with a labeled antibody enclosed therein to a container body containing a diluted liquid specimen, pouring the diluted liquid specimen from the container into a test device, observing the reaction and thus examining the... Agent: Sonnenschein Nath & Rosenthal LLP For Paula Evans
20070015143 - Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays: For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted... Agent: Leydig Voit & Mayer, Ltd
20070015141 - Process for adjusting the diameter of gold particles and colloidal gold solution: A method for estimating the particle diameter distribution width of gold colloid based on the measurement of, in addition to the maximum absorption wavelength, a ratio (AλX/Aλmax) of the absorbance (AλX) at a wavelength differing from the maximum absorption wavelength to the absorbance (Aλmax) at the maximum absorption wavelength of... Agent: Sonnenschein Nath & Rosenthal LLP For Paula Evans
20070015162 - 99 human secreted proteins: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic... Agent: Human Genome Sciences Inc Intellectual Property Dept.
20070015156 - Aberrantly methylated genes in pancreatic cancer: The present invention provides a method for detecting pancreatic carcinoma in a subject. The method includes contacting a nucleic acid-containing specimen from the subject with an agent that provides a determination of the methylation state of at least one gene or associated regulatory region of the gene and identifying aberrant... Agent: Dla Piper US LLP
20070015151 - Analytical chip with an array of immobilized specific recognition elements for the determination of clinically relevant bacteria and analytical method based thereon: The invention is related to an analytical chip for the simultaneous determination of one or more different bacterial 16S-rRNA in a liquid sample comprising—an evanescent field measurement platform, e.g. an optical waveguide, as a solid carrier and—a plurality of specific recognition elements immobilized in discrete measurement areas of known location... Agent: Wenderoth, Lind & Ponack, L.L.P.
20070015202 - Atlastin: The present invention relates to methods and compositions of a novel gene and the peptide encoded by the gene. Mutations in the gene, named atlastin, are factors in the disease Hereditary Spastic Paraplegia and related disorders. The present invention will be used for the in the research, diagnosis and treatment... Agent: Medlen & Carroll, LLP
20070015183 - Biomarkers for huntington's disease: The invention relates, in part, to specific genes and set of genes that are selectively expressed in Huntington's disease and their use for the diagnosis and staging of HD. Additionally, the selectively expressed genes are useful in methods to assess HD pathogenesis in cells, tissues, and subjects, and in the... Agent: Wolf Greenfield & Sacks, PC
20070015164 - Dairy cattle breeding for improved milk production traits in cattle: Nucleic acid molecules comprising a SNP site selected from the group consisting of position 1296 of bovine uterine milk protein (UTMP) coding sequence (SEQ ID NO: 1), position 213 of bovine signal transducer and activator of transcription (STAT1) coding sequence (SEQ ID NO: 2), position 8514 of the osteopontin (OPN)... Agent: Baker Donelson Bearman Caldwell & Berkowitz, PC
20070015154 - Differentially expressed nucleic acids that correlate with ksp expression: Nucleic acids that differentially expressed in certain tumors are provided. A variety of classification, screening, diagnostic and treatment methods are provided based upon these differentially expressed nucleic acids. Devices and kits for performing such methods are also disclosed.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20070015175 - Dna biochip and methods of use: The subject invention concerns materials and methods for detecting nucleic acid sequences. One aspect of the invention concerns a silicon-based “biochip” comprising nucleic acid immobilized thereon. In one embodiment, the silicon comprises microcavities. The nucleic acid to be assayed for the presence of one or more target nucleic acid sequences... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20070015198 - Dna sequence detection of nucleated red blood cells: Genetic modification or selection of avians requires that large numbers of birds be genetically analyzed for sequences of interest. Typically, DNA is extracted on an individual basis from samples taken from the birds. Current methods of DNA extraction extract the DNA from blood or other tissues using tedious and time-consuming... Agent: Avigenics, Inc.
20070015172 - Expression profiles for microbial infection: The invention provides methods for identifying markers of microbial infection, diagnosing microbial infections, and identifying the specific pathogen(s) involved in a microbial infection based on the signature patterns of gene expression induced in a host in response to different pathogens. The invention includes compositions and kits comprising newly identified markers... Agent: Lahive & Cockfield
20070015148 - Gene expression profiles in breast tissue: The present invention results from the examination of tissue from breast carcinomas to identify genes differentially expressed between tumor biopsies and normal tissue. The invention includes diagnostic and screening methods using these genes as well as solid supports comprising oligonucleotide arrays that are complementary to or hybridize to the differentially... Agent: Morgan Lewis & Bockius LLP
20070015182 - Generation of single-strand circular dna from linear self-annealing segments: The present invention provides a method for the rapid simultaneous production of a plurality of single-stranded DNA circles having a predetermined size and nucleotide sequence using pre-designed hairpin oligonucleotides containing complementary sequences for directing ligation to form dumbbell-shaped monomers followed by heat denaturation to yield single-stranded DNA circles.... Agent: Needle & Rosenberg, P.C.
20070015193 - Glutathione s-transferase sequence variants: Isolated GSTO2 nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as GSTO2 allozymes. Methods for determining if a subject contains a GSTO2 sequence variant also are described.... Agent: Fish & Richardson P.C.
20070015196 - Growth factor with acts through erb b-4 rtk: A novel ErbB-4 ligand, referred to herein as Neuregulin-4 (NRG-4) is disclosed as well as polynucleotide sequences encoding NRG-4, oligonucleotides and oligonucleotide analogs derived from polynucleotide sequences, a display library displaying short peptides derived from NRG-4, antibodies recognizing NRG-4, peptides or peptide analogs derived from NRG-4, and pharmaceutical compositions and... Agent: Martin D. Moynihan Prtsi, Inc.
20070015174 - High throughput formulation screening of drug candidates: Methods for screening compounds for their solubility and their solution stability in a variety of diverse formulations and sets of diverse formulations useful for screening compounds for their solubility and their solution stability.... Agent: Christensen, O'connor, Johnson, Kindness, PLLC
20070015144 - Human cdnas and proteins and uses thereof: The invention concerns GENSET polynucleotides and polypeptides. Such GENSET products may be used as reagents in forensic analyses, as chromosome markers, as tissue/cell/organelle-specific markers, in the production of expression vectors. In addition, they may be used in screening and diagnosis assays for abnormal GENSET expression and/or biological activity and for... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20070015203 - Infectious bovine viral diarrhea virus: The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.... Agent: Michael P. Morris Boehringer Ingelheim Corporation
20070015169 - Isolation of nucleic acid using colored buffers: The present invention describes isolation of plasmid DNA or nucleic acid material from Escherichia coli (E. coli) or other species of microorganisms, or from other sources. The addition of indicator dyes to the alkaline lysis based purification buffers allows for increased ease of visual monitoring of the mixing and lysis... Agent: Jonathan A. Claypool C/o Zymo Research Corp.
20070015166 - Lateral flow methods and devices for detection of nucleic acid binding proteins: Methods and devices are provided for detecting the presence or absence of nucleic acid binding proteins, such as NMP22, and other proteins, in bodily fluids.... Agent: Datascope Investment Corp.
20070015185 - Lysis and stabilization buffer suitable for inclusion in pcr reactions: The present invention provides compositions, methods, and kits for lysing cells, storing nucleic acids, amplifying nucleic acids, and analyzing nucleic acids. Among other things, the compositions, methods, and kits are suitable for one-step lysis and amplification of nucleic acid sequences of interest. In general, the compositions comprise TCEP and a... Agent: LatimerIPLaw, LLP Suite 122
20070015170 - Method and kit for detecting a risk of coronary heart disease: Genes, SNP markers and haplotypes of susceptibility or predisposition to CHD or CHD death are disclosed. Methods for diagnosis, prediction of clinical course and efficacy of treatments for CHD using polymorphisms in the CHD risk genes are also disclosed. The genes, gene products and agents of the invention are also... Agent: Birch Stewart Kolasch & Birch
20070015157 - Method and kit for the specific detection of m. tuberculosis: The invention relates to a method and system for the specific detection of a microbacterial tuberculosis (M. tuberculosis) in a biological sample, a difference being made, in particular between M. tuberculosis and other elements of M. tuberculosis complex , i.e. Microbacterium bovis (M. bovis), Microbacterium bovis BCG (M. bovis BCG),... Agent: Seed Intellectual Property Law Group PLLC
20070015167 - Method for detecting vesicoureteral reflux or interstitial cystitis: This invention provides a novel marker of vesicoureteral reflux or interstitial cystitis and a simple and non-invasive method for detecting vesicoureteral reflux or interstitial cystitis. This method comprises detection of uroplakin expression in a sample obtained from a subject.... Agent: Birch Stewart Kolasch & Birch
20070015184 - Method for identifying an intestinal phenotype: The present invention relates to a method for identifying cells having a predisposition to develop an intestinal phenotype, wherein the cells are characterized by the loss of expression of the RUNX3 gene and the expression of one or more intestinal marker genes. In particular, the invention is directed to the... Agent: Foley & Lardner LLP
20070015165 - Method for the isolation of rna from biological sources: Methods and kits for isolating RNA are provided that enable rapid RNA preparation from biological sources. In one aspect, RNA is isolated from difficult plant tissues and cells that contain high levels of secondary metabolites, without employing organic extraction or salt precipitation procedures. This method employs novel lysing and binding... Agent: Senniger Powers
20070015160 - Method of diagnosing disease relating to endometriosis: The expression level of a histamine-releasing factor (HRF) polynucleotide in a biological sample of a subject is measured and the HRF polynucleotide content is compared with that of a normal biological sample. An HRF polynucleotide expression level considerably higher than that of the normal biological sample is employed as an... Agent: Wenderoth, Lind & Ponack, L.L.P.
20070015192 - Method of herbal authentication based on 5s rrna spacer sequences: A method for authenticating herbs or plants based on sequences in trnL and/or 5S rRNA coding region. Using this method, the sequences from samples to be authenticated and samples of known identity herbs or plants are compared based on similarity percentage calculation. The authentication may also be based on phylogenetic... Agent: Fish & Richardson PC
20070015186 - Method, apparatus and system for quantifying the content of genetically modified material in a sample: A method including providing an initial test sample including a primary material and a relatively smaller amount of at least one adventitious material; combining the initial test sample with a standard addition of at least one adventitious material to form a final test sample, wherein the standard addition has a... Agent: Shumaker & Sieffert, P. A.
20070015194 - Methods and kits for diagnosing and treating mental retardation: The present invention provides methods, kits, isolated nucleic acid sequences, antibodies and addressable oligonucleotides microarrays which can be for analyzing sequence alterations and detecting the expression level of CC2D1A or nup62 in cells of an individual and thus diagnose nonsyndromic mental retardation (NSMR) and/or infantile bilateral striatal necrosis (IBSN) in... Agent: Prtsi, Inc.
20070015159 - Methods for detecting aneuploidy using microparticle multiplex detection: The present invention provides a method for the detection and sorting of microparticles in a mixture of microparticles. The method of the present invention allows for the detection and sorting of many distinct microparticle classes. Detection and sorting is on the basis of microparticle size, the fluorescence spectrum of any... Agent: Jennifer M Mccallum, Ph D, Esq The Mccallum Law Firm, LLC
20070015200 - Methods for detecting genome-wide sequence variations associated with a phenotype: The invention provides methods for determining genome-wide sequence variations associated with a phenotype of a species in a hypothesis-free manner. In the methods of the invention, a set of restriction fragments for each of a sub-population of individuals having the phenotype are generated by digesting nucleic acids from the individual... Agent: Klauber & Jackson
20070015152 - Methods for diagnosing and treating schizophrenia: The genes encoding SCYA2, GADD45B, S100A8, CDKN1A, IL1RL1, TGM2, MAFF, SERPINA3, GRO1, CD14, KIAA1075, CHI3L1, SERPINH1, MT1X, KIAA0620, TIMP1, NUMA1, DDIT3 and TOB2, are upregulated in the anterior cingulate of schizophrenic patients compared to normal patients and as such are useful drug targets for schizophrenia. Methods of screening, diagnosing and... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw
20070015168 - Methods for monitoring multiple gene expression: The present invention relates to methods for monitoring differential expression of a plurality of genes in a first Bacillus cell relative to expression of the same genes in one or more second Bacillus cells using microarrays containing Bacillus genomic sequenced tags. The present invention also relates to computer readable media... Agent: Novozymes, Inc.
20070015187 - Methods for rna profiling: The present teachings provide methods, compositions, and kits for detecting micro RNAs (miRNAs). In some embodiments, the miRNAs are quantified from formalin-fixed paraffin-embedded tissue samples in which messenger RNA is degraded. The present teachings take advantage of the observation that most mature miRNAs in vivo are protected by degradation as... Agent: Mila Kasan, Patent Dept. Applied Biosystems
20070015204 - Methods for treating viral infection using il-28 and il-29: IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof... Agent: Zymogenetics, Inc. Intellectual Property Department
20070015178 - Methods of using bone morphogenic proteins as biomarkers for determining cartilage degeneration and aging: Methods are provided for determining cartilage degeneration, regeneration, or aging in a joint tissue in a patient by measuring levels of osteogenic protein-1 (OP-1) protein and/or mRNA in synovial fluid or joint tissue. The methods according to the invention are useful for detecting, diagnosing, predicting, determining a predisposition for, or... Agent: Kirkpatrick & Lockhart Nicholson Graham LLP
20070015195 - Modified frt recombination site libraries and methods of use: Methods and compositions using populations of randomized modified FRT recombination sites to identify, isolate and/or characterize modified FRT recombination sites are provided. Kits comprising the library populations of FRT sites are also provided, as are methods to make a library of modified FRT recombination sites. The recombinogenic modified FRT recombination... Agent: Pioneer Hi-bred International, Inc.
20070015146 - Molecular nephrotoxicology modeling: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a... Agent: Morgan Lewis & Bockius LLP
20070015188 - Multiplex detection of nucleic acids: Methods of detecting nucleic acids, including methods of detecting two or more nucleic acids in multiplex branched-chain DNA assays, are provided. Nucleic acids captured on a solid support are detected, for example, through cooperative hybridization events that result in specific association of a label with the nucleic acids. Compositions, kits,... Agent: Quine Intellectual Property Law Group, P.C.
20070015191 - Network of buoyant particles for biomolecule purification and use of buoyant particles or network of buoyant particles for biomolecule purification: A network of buoyant particles for clearing lysates of biological material, the network including two or more buoyant particles covalently linked together, wherein the network ranges in size from approximately 30 microns to approximately one centimeter along the network's longest dimension. The buoyant particles may have a silica surface. The... Agent: Fitzpatrick Cella Harper & Scinto
20070015171 - Non-invasive method for isolation and detection of fetal dna: A method of detecting the presence or absence of the fetal DNA sequence of interest in fetal DNA derived from a sample of peripheral blood obtained from a pregnant woman is described. The method involves obtaining a sample peripheral blood from a pregnant woman, treating the sample of peripheral blood... Agent: Lahive & Cockfield, LLP
20070015201 - Novel 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 18636, 2466, 43238, 1983, 52881, 2398, 45449, 50289, 52872 and 26908 nucleic acid molecules, host cells... Agent: Millennium Pharmaceuticals, Inc.
20070015190 - Novel bioassay system using a nanoparticle: The invention is directed to a method for detecting a substance of interest using a nanoparticle containing a first substance and a matrix containing a second substance and detecting the radio signal emitted as a result of complex formation between the first and second substance as well as systems and... Agent: Cheryl H Agris Phd
20070015163 - Novel full-length cdna: Novel full-length cDNAs are provided. 1639 cDNA derived from human have been isolated. The full-length nucleotide sequences of the cDNA and amino acid sequences encoded by the nucleotide sequences have been determined. Because the cDNA of the present invention are full-length and contain the translation start site, they provide information... Agent: Foley And Lardner LLP Suite 500
20070015150 - Novel nucleic acid sequences and proteins of tumors and neoplasias of the thyroid gland: The Invention relates to a nucleic acid and proteins of tumors and neoplasias of the thyroid gland. Said nucleic acid comprises a nucleic acid sequence selected among the group consisting of SEQ ID No. 1, 3, 4, 9 and SEQ ID No. 11 to 16. The invention also relates to... Agent: Mcdermott Will & Emery LLP
20070015155 - Novel protein usable in screening drug improving type 2 diabetes: The present invention provides a method of screening a drug for improving type 2 diabetes. A protein CbAP40 binding to c-Cbl is found out. It is further found out that mouse CbAP40 gene shows a remarkable increase in expression amount in the muscle of diabetes model mice compared with a... Agent: Sughrue Mion, PLLC
20070015145 - Nucleic acid and amino acid sequences involved in pain: The present invention relates to nucleic acid sequences which are related to pain and which are differentially expressed during pain. The invention further relates to methods of identifying nucleic acid sequences which are differentially expressed during pain, microarrays comprising such differentially expressed sequences and methods of screening agents for the... Agent: Palmer & Dodge, LLP Kathleen M. Williams
20070015177 - Nucleic acid extraction method: The invention relates to a method for the extraction of nucleic acids from microorganisms and to the use thereof in a method for the analysis of a microbial population in a given environment, e.g. a population of microorganisms taken from the air. In particular, the invention relates to an extraction... Agent: Birch Stewart Kolasch & Birch
20070015180 - Oligonucleotide probe/primer compositions and methods for polynucleotide detection: The invention is related to a labeled oligonucleotide pair for detecting a target nucleic acid and methods, kits and compositions containing the labeled oligonucleotide pair. The labeled oligonucleotide pair forms a complex comprising a nucleic acid primer and a nucleic acid probe.... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str
20070015179 - Plastic microfluidic chip and methods for isolation of nucleic acids from biological samples: The present invention is directed to methods of manufacture of microfluidic chip such as a plastic microfluidic chips, which has channels packed with polymer-embedded particles and uses thereof. The chip of the present invention is designed for application of an untreated biological sample on the chip thus allowing isolation, purification... Agent: Ronald I. Eisenstein
20070015173 - Polypeptide nucleic sequences exported from mycobacteria, vectors comprising same and uses for diagnosing and preventing tuberculosis: Purified polynucleotides and polypeptides, and cells of M. smegmatis, M. bovis, M. bovis BCG, or M. africanum are provided.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20070015147 - Primary rat hepatocyte toxicity modeling: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of... Agent: Morgan Lewis & Bockius LLP
20070015149 - Prlz regulatory elements in the treatment of disease and the discovery of therapeutics: The compositions and methods of the present invention are based, in part, on a gene designated prostate leucine zipper (PrLZ) and the sequences that mediate its expression. The presence of the leucine zipper indicates that PrLZ encodes a protein that interacts with other proteins. Methods to inhibit the activity of... Agent: Patent Administrator Katten Muchin Rosenman LLP
20070015158 - Process for increasing ionic charge in mass spectrometry: Processes and apparatus are described for the analysis of molecules or fragments thereof, which are capable of carrying multiple charges, by reacting the multiply charged molecules or fragments thereof with other ions using mass spectrometry.... Agent: Barnes & Thornburg LLP
20070015176 - Small nucleic acid detection probes and uses thereof: The present teachings are directed to compositions, methods, and kits for detecting and quantitating small nucleic acid molecules, including small DNA molecules and small RNA molecules. The detector probes of the current teachings, including single-loop detector probes, double-loop detector probes, and bimolecular detector probes, are designed to selectively hybridize with... Agent: Mila Kasan, Patent Dept. Applied Biosystems
20070015197 - Specific binding agents for kshv vil-6 that neutralize a biological activity: A specific binding agent is provided, wherein the specific binding agent specifically binds Kaposi's sarcoma-associated herpesvirus (KSHV) interleukin-6 (vIL-6), and the specific binding agent neutralizes an activity of vIL-6. In one embodiment, the specific binding agent is an antibody. Methods are provided for using a specific binding agent that binds... Agent: Klarquist Sparkman, LLP
20070015199 - Stabilized immunogenic hbc chimer particles: A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (core) protein (HBc) that is engineered for both enhanced stability of self-assembled particles and the substantial absence of nucleic acid binding by those particles is disclosed. The chimeric protein molecule can include one or more immunogenic epitopes peptide-bonded to one or more... Agent: Edward P.gamson Suite 2200
20070015153 - Surface treatment: A method for producing a monolayer of molecules on a surface comprises: loading a stamp with seed molecules; transferring seed molecules from the stamp to the surface; and, amplifying the seed molecules via an amplifying reaction to produce the monolayer. The method permit generation of complete monolayers from incomplete or... Agent: Ibm Corporation, T.j. Watson Research Center
20070015189 - System and method to obtain oligo-peptides with specific high affinity to query proteins: The present invention relates to a method for constructing oligo-peptides with high binding affinity for a query protein.... Agent: Intellectual Property / Technology Law
20070015181 - System and methods for nucleic acid and polypeptide selection: This invention relates generally to systems and methods for identifying and selecting, desired proteins or nucleic acid molecules by linking mRNA, with known or unknown sequences, to its translated protein to form a cognate pair. The cognate pair is selected based upon desired properties of the protein or the nucleic... Agent: Knobbe Martens Olson & Bear LLP
20070015161 - Use of eukaryotic genes affecting cell cycle control or cell cycle progression for diagnosis and treatment of proliferative diseases: The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in cell cycle progression during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including... Agent: Connolly Bove Lodge & Hutz, LLP
20070015209 - Compositions and methods for diagnosing, predicting therapeutic response of, and monitoring autoimmune disease: The present invention provides methods of diagnosing the presence of an autoimmune disease in a patient, methods of predicting the response of an autoimmune diseased patient to therapeutic treatment, and methods of monitoring an autoimmune patient's response to therapy. In particular, these methods comprise the use of a glycoprotein from... Agent: Medlen & Carroll, LLP
20070015211 - Conformer-specific antibodies and method of use, thereof: A number of polypeptides exist in different three-dimensional conformations, or “conformers,” which have different biological functions despite having the same or substantially the same primary polypeptide sequences. The existence of different polypeptide conformers underlies to a variety of disease states, which may be assessed using antibody that is specific for... Agent: Foley & Lardner LLP
20070015205 - Crystal structure of phosphodiesterase 5 and use thereof: The present invention relates, inter alia, to the crystal structures of a phosphodiesterase 5 (PDE5) and PDE5/PDE5 ligand complex and their uses in identifying PDE5 ligands, including PDE5 inhibitor compounds. The present invention also relates to methods of identifying such PDE5 inhibitor compounds and their medical use. Also contemplated by... Agent: Pfizer Inc.
20070015210 - Embryoid body - based screen: Disclosed are embryoid bodies having a uniform size of approximately 415 nm and comprising genetically modified embryonic stem cells, and methods of making same. The genetically uniform embryoid bodies can be multiplexed as one embryoid body per well in a multiwell format, and used as a high to medium throughput... Agent: Joseph E. Zahner
20070015216 - Isoprenoid biosynthesis: The present invention relates to enzymatic activity involved in isoprenoid biosynthesis as well as to inhibitors, notably herbicides, for enzymes in the biosynthesis of isoprenoids. More specifically, the present invention relates to screening methods for detecting such inhibitors, and to enzymatically active proteins for performing said methods as well as... Agent: Myers Bigel Sibley & Sajovec
20070015206 - Method for detecting and/or removing protien comprising a cross-beta structure from a pharmaceutical composition: The invention relates to the detection and/or removal of conformationally altered proteins and/or molecules comprising a cross-β structure from a pharmaceutical composition or any of its constituents comprising a protein. Disclosed iss that unwanted and/or toxic side effects of pharmaceuticals are caused by proteins present in the pharmaceutical and adopting... Agent: Trask Britt
20070015214 - Methods for identifying compounds for regulating muscle mass or function using prostanoid ip receptors: Methods for identifying compounds that bind to or activate prostanoid IP receptors and potentially regulate skeletal muscle mass or function are disclosed. Pharmaceutical compositions comprising IP receptor agonists and methods for increasing skeletal muscle mass or function or for the treatment of skeletal muscle atrophy using IP receptor as the... Agent: The Procter & Gamble Company Intellectual Property Division
20070015212 - Mitochondrial markers of ischemia: Damage to tissue, such as ischemic damage, can cause the release of mitochondrial proteins. The released proteins can be detected in a sample taken from a subject, indicating that the subject has suffered damage.... Agent: Michaud-duffy Group LLP
20070015215 - Modified phycobilisomes and uses therefor: This invention provides modified phycobilisomes and phycobilisome complexes that are supramolecular complexes with diverse-spectral properties, and which may optionally be immobilized on a manufactured solid support. The invention provides a versatile set of highly sensitive signal-generating systems and conjugates that may be used as highly detectable tracers and labels, or... Agent: Hunton & Williams LLP Intellectual Property Department
20070015208 - Multimarker panel for diabetes type 1 and 2: The present invention relates to a method and means for diagnosing or risk stratification of co-morbidities, particularly cardiovascular complications in diabetes patients. The invention particularly relates to a method for diagnosing whether a diabetes patient is suffering from a cardiovascular complication or is at risk of suffering from a cardiovascular... Agent: Roche Diagnostics Operations Inc.
20070015213 - Peptide arrays and methods of preparation: The present invention relates to arrays of peptidic molecules and the preparation of peptide arrays using focused acoustic energy. The arrays are prepared by acoustically ejecting peptide-containing fluid droplets from individual reservoirs towards designated sites on a substrate for attachment thereto.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.c
20070015207 - Triazolopyrimidine derivatives: The invention relates to the discovery of triazolopyrimidine derivatives of formula (I), which have been found to exhibit inhibitory activity against the serine-tyrosine and tyrosine kinases.... Agent: Philip S. Johnson Johnson & Johnson
20070015218 - A method for the separation anti-amyloid beta antibody with amyloid beta peptide: The present invention is a method of effectively dissociating an antibody and antigen from the complex they form. The method enables researchers to accurately identify anti-amyloid beta peptide and its antibody from sera samples. It can also be used for the evaluation of the outcome of Alzheimer's patient treatment based... Agent: Smith Hopen, Pa
20070015221 - Fragment of neurosecretory protein vgf as a biomarker for alzheimer's disease: The present invention provides a neurosecretory protein VGF peptide useful in qualifying Alzheimer's disease status in a patient. In particular, this peptide and modified forms thereof may be used to classify a subject sample as Alzheimer's disease or non-Alzheimer's disease. The peptide biomarker can be detected by SELDI mass spectrometry.... Agent: Townsend And Townsend And Crew LLP
20070015220 - Novel guanosine triphosphate (gtp) binding protein-coupled receptor proteins: A full-length cDNA encoding a human-derived G protein-coupled receptor protein is isolated by screening a human hippocampus library. Also, a rat-derived cDNA corresponding to the human-derived cDNA is isolated. Proteins encoded by these cDNAs have an activity of lowering intracellular cAMP concentration under stimulation with histamine. These proteins are usable... Agent: Fish & Richardson PC
20070015217 - Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of alzheimer's disease: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated Features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20070015219 - Tnf receptor-like molecules and uses thereof: Novel MK61 polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing MK61 polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with MK61 polypeptides.... Agent: Marshall, Gerstein & Borun LLP
20070015224 - Methods and compositions to diagnose trichomonas infection: The present invention provides methods and compositions for diagnosing Trichomonas infection by detecting an antibody that specifically binds a Trichomonas α-actinin protein in a sample from a subject.... Agent: Myers Bigel Sibley & Sajovec
20070015226 - Method for detecting cancer using metal-oxide or metal-sulfide nanoparticle fluorescent material: It is an object of the present invention to provide a nanoparticle fluorescent material for detecting cancer with which cancer can be detected with high sensitivity, using highly safe and broad light emission on a simple device. The present invention provides a nanoparticle fluorescent material which comprises a metal-oxide or... Agent: Buchanan, Ingersoll & Rooney PC
20070015225 - Methods for increasing the proliferation of b cells: Disclosed herein are methods of increasing the proliferation of non-tumorigenic B cells. The methods involve administering PCDGF and optionally other B cells stimulators (e.g., IgM, LPS) to B cells resulting in an increase in B cell proliferation. The methods of the invention can be used, for example, to establish B... Agent: Dickstein Shapiro LLP
20070015222 - Isotope labeling methods: The present invention relates to a method for the analysis of differential expression of proteins employing a radioactive label, characterized by cleaving a tag from peptides labeled with a cICAT reagent, separating and purifying the resultant labeled peptides, and performing an analysis in mass spectrometry.... Agent: Sughrue Mion, PLLC
20070015223 - Method of detecting substance to be analyzed: An object of the invention is to provide a quick, easy, and highly-sensitive method of detecting a substance to be analyzed, and to provide a method of supporting the analysis results by quantitativeness even if the amount of samples to be handled is a very small amount. The invention is... Agent: Scully Scott Murphy & Presser, PC
20070015228 - Assay for antibodies: The presence and quantity of an antibody of interest in a patient's bloodstream or other biological sample can serve as an important clinical or other analytical or diagnostic tool. ELISA methods, and kits for such assays, as well as anti-idiotypic antibodies and hybridomas producing them, are developed to detect levels... Agent: Genentech, Inc.
20070015227 - Non-invasive enzyme screen for tissue remodeling associated conditions: Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzymes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of cancer, metastatic cancer, and obstructive and degenerative conditions.... Agent: David S. Resnick
20070015229 - Secretory or membrane-binding chimeric protein: A secretory or membrane-binding chimeric protein composed of an energy-generating protein and an energy-receiving protein linked one another wherein energy transfer can arise between the energy-generating protein and the energy-receiving protein.... Agent: Knobbe Martens Olson & Bear LLP
20070015230 - Identification and characterization of analytes from whole blood: The invention provides a method of identifying and detecting targets in blood samples by binding to multiple ligands. The method comprises providing ligands attached to a support, and contacting the ligands with targets in blood to allow at least one target to bind to at least one ligand. The method... Agent: Merchant & Gould PC
20070015231 - Assay for protein tyrosine phosphatases: The invention relates in part to screening assays for identifying agents that alter the interaction between a protein tyrosine phosphatase (PTP) and its tyrosine phosphorylated polypeptide substrate, using fluorescence energy signals generated by detectably labeled substrates. Assays are provided in certain embodiments, including high throughput screening assays, wherein candidate agents... Agent: Seed Intellectual Property Law Group PLLC
20070015232 - Mitotic index assay: Mitosis of cells is determined, particularly in the presence of a candidate agent, using cells comprising members of an enzyme fragmentation complex pair, where one of the members is in the nucleus and the other member is in the cytoplasm. By growing the cells where mitosis may occur, one adds... Agent: Peters Verny Jones & Schmitt, L.L.P.
20070015233 - Analysis of molecules: There is disclosed a method of analysing one or more molecules having a primary amine or a lysine functionality in two or more samples comprising the steps of: providing a series of reagents having the formula R1—NH—C(═NH)—OR2 where R1 and R2 are residue groups or atoms, and wherein the chemical... Agent: Jacobson Holman PLLC
20070015234 - Whole cell assay for inhibitors of cathepsin k: The present invention relates to a method of identifying and evaluating chemical inhibitors of cathepsin K activity in whole cells. The present invention also relates to probes that are capable of forming irreversible adducts with cathepsin K at the active site. The probes used in the instant invention comprise a... Agent: Merck And Co., Inc
20070015235 - Assays employing novel substrates for measuring p450-mediated n-dealkylation: Methods and compositions for measuring N-dealkylating activity of cytochromes P450 enyzmes are disclosed.... Agent: Dann, Dorfman, Herrell & Skillman
20070015236 - Process of preparing prednisolone devoid of steroid-derived impurities using recombinant e. coli transformed with a delta¹-dehydrogenase gene: The present invention relates to a process of using recombinant E. coli having a Δ1-dehydrogenase gene to prepare prednisolone. Specifically, the present invention relates to a fermentation process of using recombinant E. coli containing a Δ1-dehydrogenase gene to prepare prednisolone that is devoid of steroid-derived impurities.... Agent: Taro Pharmaceuticals U.s.a., Inc. C/o Venable LLP
20070015237 - Production of carotenoids in oleaginous yeast and fungi: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids... Agent: Choate, Hall & Stewart LLP
20070015243 - Chimeric empty viral-like particles derived from the infectious bursal disease virus (ibdv), process for their production and applications: The chimeric empty viral-like particles derived from the infectious bursal disease virus (IBDV) are formed by the assembly of fusion proteins comprising a region A consisting of an IBDV pVP2 protein or a “1-n” fragment of said IBDV pVP2, wherein “n” is an integer comprised between 441 and 501, bound... Agent: Klarquist Sparkman, LLP
20070015249 - Chondroitin polymerase and dna encoding the same: A chondroitin polymerase having such properties that it transfers GlcUA and GalNAc alternately to a non-reduced terminal of a sugar chain from a GlcUA donor and a GalNAc donor, respectively, and the like; and a process for producing the chondroitin polymerase.... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.
20070015239 - Correlation between the fucose content/galactose content ratio of anti-rhesus-d and anti-hla-dr antibodies and the adcc activity: The present invention relates to monoclonal antibodies with high ADCC activity, characterised in having glycannic structures with a ratio (fucose content/galactose content) of 0.6 or less on the glycosylation site thereof in the Fc region. The invention also relates to pharmaceutical compositions, containing said monoclonal antibodies with high effector activity.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik
20070015251 - Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield
20070015252 - Corynebacterium glutamicum genes encoding regulatory proteins: Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield
20070015254 - Crystal harvest from fermentation broth: A method for producing a crystalline and/or amorphous metabolite suspension from a fermentation broth comprising treating the fermentation broth with one or more coagulants and/or one or more flocculants; and separating the biomass of the fermentation broth from the coagulated and/or flocculated fermentation broth by use of a separation equipment,... Agent: Novozymes North America, Inc.
20070015248 - Expression vector and use thereof: The present invention relates to an expression vector for the use in an auxotrophic, prokaryotic host cell and relates to an expression system containing an expression vector and an auxotrophic, prokaryotic host cell. The invention furthermore relates to an antibiotic-free fermentation medium containing an expression vector as mentioned above as... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20070015253 - Latent fusion protein: The present invention provides a method for providing latency to a pharmaceutically active agent. The method has application in overcoming the toxic effect of systemic administration of potent biological agents. The method comprises associating a fusion protein comprising a latency associated peptide and a proteolytic cleavage site with a pharmaceutically... Agent: Sterne, Kessler, Goldstein & Fox PLLC
20070015247 - Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method: A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically cross-react with two or more different receptors to which Apo-2 ligand (Apo-2L) can bind.... Agent: Genentech, Inc.
20070015250 - Methods and compositions for increasing longevity and protein yield from a cell culture: Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant Bcl-2 gene,... Agent: Faegre & Benson LLP Patent Docketing
20070015242 - Neostatins: The invention provides fragments of type XVIII collagen termed neostatins, and methods for their use in the treatment of ophthalmological disorders associated with angiogenesis.... Agent: Fish & Richardson PC
20070015246 - Novel prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods: The invention provides novel STAMP2 nucleic acid molecules, polypeptides, antibodies, and modulatory compounds for use in methods of diagnosing, treating, and preventing diseases and conditions of the prostate and testis, such as cancer.... Agent: Clark & Elbing LLP
20070015245 - Production of a highly active, soluble form of the cytochrome p450 reductase (cpr a) from candida tropicalis: The present invention provides soluble cytochrome p450 reductase (CPR) proteins from Candida sp. having an altered N-terminal region which results in reduced hydrophobicity of the N-terminal region. Also provided are host cells comprising the subject soluble CPR proteins. In addition, the present invention provides nucleotide and corresponding amino acid sequences... Agent: Cognis Corporation Patent Department
20070015238 - Production of pseudotyped recombinant aav virions: Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped recombinant AAV (rAAV) virions. Purification methods generated pseudotyped rAAV virion stocks that were 99% pure with titers of 1×1012−1×1013 vector genomes/ml.... Agent: Akerman Senterfitt
20070015240 - Subtilases: The present invention relates to methods for producing variants of a parent JP170 subtilase and of a parent BPN′ subtilase and to JP170 and BPN′ variants having altered properties as compared to the parent JP170/BPN′ subtilase.... Agent: Novozymes North America, Inc.
20070015241 - Sulfur atom-free enzyme protein: A sulfur atom-free enzyme protein retaining the activity of the original enzyme protein and having oxidation resistance wherein L-cystein and L-methionine residues of the enzyme protein are substituted with 18 types of L-amino acid residues: L-alanine; L-aspartic acid; L-glutamic acid; L-phenylalanine; L-glycine; L-histidine; L-isoleucine; L-lysine; L-leucine; L-asparagine; L-proline; L-glutamine; L-arginine;... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
20070015244 - System for antibody expression and assembly: The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and eukaryotic expression systems. Particularly contemplated are recombinant systems for temporally separated expression of light chain and heavy chain of antibodies. The antibody products including antibody fragments can... Agent: Merchant & Gould PC
20070015255 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20070015256 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20070015257 - Alpha-msh related compounds and methods of use: The invention provides polypeptides containing α-MSH that can be used to treat diseases characterized by inflammation and/or autoimmunity. Also included in the invention are α-MSH analogs and nucleic acids encoding polypeptides containing α-MSH and α-MSH analogs optionally linked to heterologous sequences. Also included in the invention are methods of delivering... Agent: Fish & Richardson PC
20070015258 - Alpha-beta c4bp -type recombinant heteromultimeric proteins: A recombinant heteromultimeric protein including at least (a) a polypeptide fusion molecule A consisting of a C4BP α-chain C-terminal fragment and a polypeptide fragment heterologous to said a chain, and (b) a polypeptide fusion molecule B consisting of a C4BP β-chain C-terminal fragment and a polypeptide fragment heterologous to said... Agent: Venable LLP
20070015259 - Fusion partner for production of monoclonal rabbit antibodies: The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not detectably express endogenous immunoglobulin heavy chain and may contain, in certain embodiments, an altered immunoglobulin heavy chain-encoding gene. A hybridoma resulting from... Agent: Bozicevic, Field & Francis LLP
20070015260 - Synthesis of synthons for the manufacture of bioactive compounds: The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 126.96.36.199) and variants thereof can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor aldehydes. The reaction products typically contain at least two new stereogenic centers and can be produced... Agent: Dla Piper US LLP
20070015261 - Altered glyoxylate shunt for improved production of aspartate-derived amino acids and chemicals: The invention provides microbial strains possessing improved properties for production of aspartate-derived amino acids and chemicals. Methods of making such strains are provided. These methods include altering expression of the aceBAK operon, the glcB gene, or both. Alteration of expression may be accomplished through increased transcription, relief from native transcriptional... Agent: Buchanan Ingersoll PC (archer Daniels Midland Company)
20070015262 - Extracts from ajuga reptans cell lines, their preparation and use: The present invention relates to selected and stabilized cell line extracts from Ajuga reptans comprising phenylpropanoids having high antioxidating capacity with a teupolioside titre of between 20% and 90% and a chromophore-free fraction of between 80% and 10%. Said extracts are for use in human and veterinary therapy and for... Agent: Merchant & Gould PC
20070015263 - Method for increasing yield of biomass of and/or components of biomass from marine microorganisms: The present invention provides an optimized method of continuously culturing an auxotrophic marine microorganism in a fermentor under aerobic conditions at Y g/l of cell dry matter, CDM, wherein Y is in the range from 100-300 g/l, comprising culturing said auxotrophic marine microorganism in a culture medium comprising a carbon... Agent: Novozymes North America, Inc.
20070015264 - Method for producing organic acid ammonium solution: Organic acid ammonium solution is produced by the steps of obtaining a fermentation broth containing organic acid magnesium by using an organic acid-producing microorganism in the presence of a magnesium compound, producing organic acid ammonium and a magnesium compound by subjecting the organic acid magnesium contained in the fermentation broth... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.
20070015265 - Novel gluconate dehydratase: A novel gluconate dehydratase derived from Achromobacter xylosoxidans and a gene encoding the gluconate dehydratase are provided. By reacting the gluconate dehydratase or a transformed cell containing the gene with an aldonic acid, the corresponding 2-keto-3-deoxyaldonic acid can be efficiently produced.... Agent: Buchanan, Ingersoll & Rooney PC
20070015266 - Trichoderma reesei glucoamylase and homologs thereof: The present invention is related to glucoamylases having at least 80% sequence identity to a Trichoderma glucoamylase having the sequence of SEQ ID NO: 4 and biologically functional fragments thereof. The invention is also related to DNA sequences coding for the glucoamylases, vectors and host cells incorporating the DNA sequences,... Agent: Lynn Marcus-wyner Genecor Interational, Inc.
20070015268 - Entrapping immobilization pellets and process for producing the same: The present invention produces entrapping immobilization pellets which have high pellet strength and retain high and stable microbial activity (nitrification activity) even if a low concentration of a material involved in immobilization (such as an immobilizing material or polymerization initiator) used. The entrapping immobilization pellets in which microorganisms are entrapped... Agent: Oliff & Berridge, PLC
20070015267 - Method for producing composite objects using expanded graphite and vermiculite: A method for producing a composite object includes at least two distinct parts having different properties and/or functions, which includes forming at least one layer (53) having more than 70 wt. % of an expanded material selected from expanded graphites, forming at least one other layer (52) and more than... Agent: Young & Thompson
20070015270 - Crystalline pde4d2 catalytic domain complex, and methods for making and employing same: The presently disclosed subject matter provides a crystalline form of a substantially pure phosphodiesterase 4D2 (PDE4D2) polypeptide. Also provided is a crystalline form of a substantially pure phosphodiesterase 4D2 (PDE4D2) polypeptide in complex with a ligand. Also provided are methods for generating the crystalline forms of the presently disclosed subject... Agent: Jenkins & Wilson, Pa
20070015269 - Crystals of dpp-iv: The present invention provides a crystal of the extracellular domain of mammalian DPP-IV, wherein the crystal has an orthorhombic space group of P212121 and one homodimer of DPP-IV in the asymmetric unit. Also provided is a co-crystal which includes a ligand bound to the active site of mammalian DPP-IV. The... Agent: Hoffmann-la Roche Inc. Patent Law Department
20070015271 - Human secreted proteins: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors,... Agent: Human Genome Sciences Inc
20070015272 - Toxicity testing apparatus for cell stack cultures: A toxicity testing apparatus for testing toxicity of a sample with respect to a cell stack culture comprises an incubator for incubating at least one cell stack culture, a culture medium exchanger for exchanging a culture medium for the cell stack culture, a sample dispenser for adding the sample to... Agent: Sughrue Mion, PLLC
20070015273 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati
20070015274 - Devices and methods for pharmacokinetic-based cell culture system: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati
20070015275 - Devices and methods for pharmacokinetic-based cell culture systems: Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device.... Agent: Wilson Sonsini Goodrich & Rosati
20070015276 - Fluid transfer device: Fluid transfer devices described herein can include a body portion and a tip portion. A fluid pathway extends through the body and tip portions through which fluid may be transferred, for example, from a fluid-dispensing apparatus to a fluidic chamber of a microreactor. In some embodiments, the fluid transfer device... Agent: Wolf Greenfield & Sacks, PC
20070015277 - Substrate for cell transfer: A main object of the present invention is to provide a cell transfer substrate capable of transplanting cells, maintaining a pattern as it is, on a living body tissue or the like, even when: the size of the cell sheet is extremely small; the cells are cultured sparsely; the cells... Agent: Ladas & Parry LLP
20070015278 - Methods of isolating differentiable cells from placental-associated tissue and uses thereof: The invention relates to methods of isolating differentiable fetal-derived cells from various tissues of the placenta. Specifically, some of the methods of the present invention relate to isolating differentiable amnion-derived cells, while other methods of the present invention relate to isolating differentiable chorion-derived cells. The present invention also relates to... Agent: David W. Highet, Vp And ChiefIPCounsel Becton, Dickinson And Company
20070015279 - Methods of selecting pancreatic endocrine cells using protein synthesis inhibitors: The present invention relates to methods of selecting pancreatic endocrine cells from total pancreatic cells by incubation with protein synthesis inhibitors.... Agent: Townsend And Townsend And Crew, LLP
20070015280 - Production of cultured human mast cells and basophils for high throughput small molecule drug discovery: Provided are methods for producing and screening proliferated populations of CD34-negative progenitor cells, mucosal mast cells, connective tissue-type mast cells and basophil cells. The methods generate uniform proliferated populations of cells. The proliferated populations contain a uniform population of a size suitable for use in high throughput screening methods, for... Agent: Dechert LLP
20070015281 - Ready-to-use electroporation cuvette including frozen electrocompetent cells: A ready-to-use electroporation cuvette is provided that includes a cuvette, first and second electrodes positioned within the cuvette and electroporation competent cells frozen in a suspension solution within the cuvette, wherein the electroporation cuvette is configured to permit electroporation of the cells when the cells are thawed. The electroporation cuvette... Agent: Proskauer Rose LLP
20070015282 - Circular dna molecule having a conditional origin of replication, process for their preparation and their use in gene therapy: A circular DNA molecule, useful for gene therapy, comprising at least one nucleic acid sequence of interest, characterised in that the region allowing the replication thereof has an origin of replication with a functionality in a host cell that requires the presence of at least one specific protein foreign to... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP01/11/2007 > 152 patent applications in 41 patent subcategories. USPTO class patent listing
20070009880 - methods and solutions for storing donor organs: The present invention provides methods of preserving, storing and transplanting mammalian donor organs. The method includes the cooling of refrigeration preservation, loading pre-freezer preservation, cryopreservation, and washing solutions at least containing polyvinylpyrrolidone, a calcium channel blocker, a nucleoside, potassium chloride, polyethylene glycol, at least one amino acid, and a steroid... Agent: Wilson Sonsini Goodrich & Rosati
20070009881 - Perfusion circuit: A perfusion system for the extracorporeal preservation of vitality or regeneration of organs, limbs or tissue lobes for use in transplant surgery, extracorporeal support of the liver, or for biochemical or pharmacological study of isolated organs. The system comprises an organ perfusion chamber filled with dialysate as the storage fluid... Agent: Bohan, Mathers & Associates, LLC
20070009882 - In vitro platform for screening agents inducing islet cell neogenesis: The present invention relates to an in vitro method for screening agents inducing islet cell neogenesis or duct-to-islet cell transdifferentiation, which comprises the steps of: a) expanding in vitro cells of a duct-like structure obtained by inducing cystic formation in cells in or associated with post-natal islets of Langerhans; b)... Agent: Bereskin And Parr
20070009883 - Low fluorescence assay platforms and related methods for drug discovery: One aspect of the present invention is a multi-well platform for fluorescence measurements, comprising a plurality of wells within a frame, wherein the multi-well platform has low fluorescence background. Another aspect of the present invention is a system for spectroscopic measurements, comprising reagents for an assay and a multi-well platform... Agent: Lisa A. Haile, J.d., Ph.d. Dla Piper US LLP
20070009884 - Methods and apparatuses for detecting chemical or biological agents: The present invention provides methods and apparatuses for detection of pathogens or toxins in a sample. The invention also provides kits comprises reagents, including probes sets, and other consumables, such as surfaces, which can be used for detection of pathogens or toxins in a sample.... Agent: The Law Office Of Steven G Roeder
20070009885 - Methods and compositions for the detection of cervical disease: Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical... Agent: Alston & Bird LLP
20070009935 - Arrangements, systems and methods capable of providing spectral-domain optical coherence reflectometry for a sensitive detection of chemical and biological sample: Systems, arrangements and methods for a molecular recognition are provided. For example, a particular radiation having wavelength that varies over time and/or a spectral width that is greater than 10 nm can be provided. For example, at least one first electro-magnetic radiation can be provided to at least one sample,... Agent: Dorsey & Whitney LLP Intellectual Property Department
20070009944 - Assay for nucleic acid ligase and nucleic acid nuclease: A method of determining activity of a nucleic acid ligase or a nucleic acid nuclease is described. This method comprises the steps of: (i) providing a nucleic acid molecule comprising a hairpin with a single-stranded loop and a double-stranded stem containing a target site for the nucleic acid ligase and/or... Agent: Heller Ehrman White & Mcauliffe LLP
20070009919 - Atm kinase compositions and methods: The present invention provides methods for detecting activation of ATM kinase, DNA damage, and DNA damaging agents. Further provided are antibodies which specifically recognize the phosphorylation state of Ataxia Telangiectasia-Mutated (ATM) kinase. Methods of identifying agents which modulate the activation and activity of ATM kinase are also provided.... Agent: Darby & Darby
20070009940 - Biomarkers for neuropsychiatric disorders: The present invention provides diagnostic markers of neuropsychiatric disorders (e.g., schizophrenia, schizoaffective disorder or serious mood disorders including bipolar disorder and recurrent unipolar disorder) for use in diagnosis, drug screening, therapy monitoring, research and therapeutic applications. In particular, the present invention provides SLC18A1 and TAAR2, and mutations therein, as biomarkers... Agent: David A. Casimir Medlen & Carroll, LLP
20070009926 - Biomarkers of resistance to infections in humans and biological applications thereof: The invention relates to the use of IL-22 alone or in combination as biomarker of resistance to infections in humans when added to of one or several agonists of the formyl peptide receptors (FPR) receptors family and formyl peptide receptors-like 1 (FPRL 1). Said biomarker is useful in diagnostics, prophylaxis... Agent: Nixon & Vanderhye, PC
20070009886 - Carbohydrate-associated proteins: Various embodiments of the invention provide human carbohydrate-associated proteins (CHOP) and polynucleotides which identify and encode CHOP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CHOP.... Agent: Foley And Lardner LLP Suite 500
20070009941 - Complementary dnas: The sequences of extended cDNAs encoding secreted proteins are disclosed. The extended cDNAs can be used to express secreted proteins or portions thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The extended cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20070009888 - Compositions, splice variants and methods relating to breast specific genes and proteins: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of... Agent: Licata & Tyrrell P.C.
20070009917 - Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays: This invention relates to detection of specific extracellular nucleic acid in plasma or serum fractions of human or animal blood associated with neoplastic or proliferative disease. Specifically, the invention relates to detection of nucleic acid derived from mutant oncogenes or other tumor-associated DNA, and to those methods of detecting and... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20070009911 - Diagnostic test kits: This invention provides kits, devices, and methods for the detection of antibodies that recognize one or more proteins and/or antigens from porcine reproductive and respiratory syndrome virus (PRRSV). The antibodies may be in a biological fluid of a PRRSV infected or at risk subject. The invention may be advantageously applied... Agent: Townsend And Townsend And Crew, LLP
20070009920 - Drug trial assay system: The invention provides a method for improving the efficacy of drug trials, the method comprising the step of screening samples from potential participants for the genetic basis of Gilbert's Syndrome and eliminating or including potential participants in a drug trial in the knowledge of them possessing or not possessing the... Agent: Fish & Richardson PC
20070009921 - Fragments of virus protein 2 or 3 of polyoma virus as vehicles for active substances: The invention relates to a synthetic, biologically active molecule for fixing an active ingredient to the virus protein 1 (VP1) of the polyoma virus. According to the invention, an amino acid sequence A1 which is derived from the C-terminal end of virus protein 2 (VP2) or 3 (VP3) of the... Agent: Fish & Richardson P.C.
20070009951 - Gene expression vaccine: An effective prophylactic mucosal gene expression vaccine (GXV), made up of a cocktail of at least 4 different plasmid DNAs encoding corresponding RSV antigens, coacervated with chitosan to formulate nanospheres. In a murine model of RSV infection, intranasal administration with GXV results in significant induction of RSV-specific antibodies, nasal IgA... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20070009928 - Gene synthesis using pooled dna: A method and system for synthesizing one or more pieces of DNA with desired sequences using pooled DNA, the method comprising a hierarchical division phase and a hierarchical assembly phase. In the division phase, the sequences of one or more pieces of DNA with desired nucleic acid sequences are recursively:... Agent: Knobbe Martens Olson & Bear LLP
20070009925 - Genomic dna sequencing methods and kits: The disclosed teachings provide methods and kits for determining the sequence of a gDNA target region comprising multiple amplification steps and sequencing at least part of the amplification product of one or more amplification reactions.... Agent: Mila Kasan, Patent Dept. Applied Biosystems
20070009887 - Genotyping of deafness by oligonucleotide microarray analysis: A method for genotyping a subject with respect to a gene or target nucleic acid sequence associated with a pathological condition, said method comprising contacting an allele specific oligonucleotide immobilized to a solid support with a single-stranded from of RNA or DNA from a subject to be tested labeled directly... Agent: Scully, Scott, Murphy & Presser
20070009916 - Guanosine triphosphate-binding protein coupled receptors: The object of the present invention is to provide a technique for efficiently extracting GPCR sequences from human genome sequences, thereby comprehensively identifying novel GPCRs. An original automatic system for identifying GPCR sequences is disclosed, and 1035 novel GPCRs are successfully identified from the entire human genome by utilizing the... Agent: Foley And Lardner LLP Suite 500
20070009922 - Hot start polymerase reaction using a thermolabile blocker: The invention relates to compositions, methods, and kits for hot start polynucleotide synthesis, including extension of primed polynucleotide templates and polymerase chain reaction (PCR). Hot start is provided by a thermally inactivated blocking polymerase protein that binds primed polynucleotide templates and prevents their access to a thermostable nucleic acid polymerase.... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str
20070009908 - Human stanniocalcin-alpha: A human stanniocalcin-alpha polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the regulation of electrolyte imbalances which can lead to renal, bone and heart diseases and osteoporosis and Paget's Disease.... Agent: Human Genome Sciences Inc. Intellectual Property Dept.
20070009946 - Identification of viral agents in breast ducts and antiviral therapy therefore: Methods and systems for identifying a virus in breast ducts are provided. In addition, antiviral therapy for treating a virally infected breast duct is also provided. Patients with a viral infection identified in the breast ducts may be at risk for developing breast precancer or cancer.... Agent: Cytyc Corporation
20070009914 - Labeled complimentary oligonucleotides to detect oligonucleotide-linked ligands: Methods for determining the presence of an analyte in a sample are disclosed, in which a capture agent is bound to the analyte at a first epitope and a detection agent is bound at a second epitope, and in which the detection agent includes an oligonucleotide to which a labeled,... Agent: Beckman Coulter Inc. C/o Sheldon Mak Rose & Anderson
20070009937 - Mapping of proteins along chromatin by chromatin cleavage: The present invention is directed to a method for localising, in chromatin or DNA, the binding loci of a chromatin or DNA binding protein comprising the following steps: a) tethering, directly or indirectly, an enzyme with regulatable activity to said chromatin binding protein, b) transiently activating the regulatable enzymatic activity... Agent: Cooper & Dunham, LLP
20070009934 - Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer: This invention relates to the use of tumor-derived or associated extracellular ribonucleic acid (RNA) found circulating in the plasma or serum fraction of blood for the detection, monitoring, or evaluation of cancer or premalignant conditions. Extracellular RNA may circulate as non-bound RNA, protein-bound RNA, lipid-RNA complexes, lipoprotein (proteolipid)—RNA complexes, protein-RNA... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20070009896 - Method for detecting mutation and method of inducing the same: A novel plant transposon that induces bud mutation, transposase thereof, and a method for efficiently inducing bud mutation by improvement in the transposition efficiency are provided. A novel transposon having terminal inverted repeat sequences (SEQ ID NO: 1 and SEQ ID NO: 2) shown below has been isolated for the... Agent: Foley And Lardner LLP Suite 500
20070009953 - Method for detecting west nile virus nucleic acids in the 5' non-coding/capsid region: Compositions, methods and kits for detecting flavivirus nucleic acids. Particularly described are methods for detecting very low levels of West Nile virus nucleic acids in the 5′ non-coding/capsid region.... Agent: Gen Probe Incorporated
20070009893 - Method for isolating and purifying a nucleic acid: The present invention is a method for isolating and purifying a nucleic acid, where generation of foams is able to be suppressed whereby the isolation and purification of a nucleic acid are easily and efficiently carried out, the method for isolating and purifying a nucleic acid comprising the step of:... Agent: Birch Stewart Kolasch & Birch
20070009891 - Method for the isolation of expressed sequence tags in plants: A method is described for the isolation of Expressed Sequence Tags (ESTs) which are based on the use of suitable quantities of 5-azaCytidine in the germination phase of plants to induce the demethylation phenomenon of the DNA. In this way, it is possible to obtain “totipotent” seedlings, i.e. capable of... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.
20070009897 - Method of detecting genetic polymorphism: The present invention relates to a method for detecting gene polymorphism by PCR, using, as a primer, an oligonucleotide, wherein the third nucleotide from the 3′-end thereof is a 2′-O,4′-C-ethylene nucleotide (ENA) unit, the other oligonucleotides are natural oligonucleotides, the 3′-end position thereof is a nucleotide complementary to the nucleotide... Agent: Frishauf, Holtz, Goodman & Chick, PC
20070009895 - Method of interaction analysis and interaction analyzer: A method is provided in which an extremely small amount of a solution containing a substance to be analyzed can be analyzed with high throughput and without any loss of the solution. The method comprises the steps of introducing into a separation channel a first solution containing a substance that... Agent: Birch Stewart Kolasch & Birch
20070009898 - Method of mass spectrometry: A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally... Agent: Waters Investments Limited C/o Waters Corporation
20070009892 - Method of preparing epitopes chimeric gene vaccine: The invention relates to a method for preparing polyepitope chimeric gene vaccines, designated as Epitopes Assemble Library Immunization (EALI). It involves the construction of expression libraries of polyepitope chimeric genes with different sizes and lengths using gene shuffling and random assembly so as to screen polyepitope chimeric gene vaccines. Immunization... Agent: Jenkins, Wilson, Taylor & Hunt, P. A.
20070009913 - Method of treatment of rna sample: The invention relates to methods for treating samples of RNA. In an embodiment the method includes contacting the sample of RNA with an analogous DNA set to provide a DNA/RNA duplex. The analogous DNA set includes at least one sequence analogous to a small RNA. The method includes contacting the... Agent: Agilent Technologies Inc.
20070009942 - Methods and compositions for evolving hydrogenase genes: The invention provides methods and compositions for engineering microbes to generate Hydrogen. Some methods of the invention involve recoding of hydrogenase genes followed by subjecting the recoded genes to annealing-based recombination methods. The invention further provides methods of mating organisms that are transformed with recoded and recombined hydrogenase genes with... Agent: Harrison F. Dillon
20070009930 - Methods and compositions for polypeptide engineering: Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.... Agent: Maxygen, Inc. Intellectual Property Department
20070009927 - Methods and compositions for prenatal diagnosis of mental retardation: Methods and compositions for the diagnosis of mental retardation are provided.... Agent: Dann, Dorfman, Herrell & Skillman
20070009918 - Methods and compositions for regulating t cell subsets by modulating transcription factor activity: Methods for modulating production of a T helper type 2 (Th2)-associated cytokine, in particular interleukin-4, by modulating the activity of a transcription factor, in particular the proto-oncoprotein c-Maf, that regulates expression of the Th2-associated cytokine gene are disclosed. Methods for modulating development of T helper type 1 (Th1) or T... Agent: Lahive & Cockfield, LLP
20070009950 - Methods and compositions for vitamin k epoxide reductase: The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphism is correlated with increased or decreased sensitivity to warfarin, thereby identifying... Agent: Myers Bigel Sibley & Sajovec
20070009943 - Methods, uses and compositions for determining redisposition to cancers by identifying specific genotypes of cyp1b1 gene: The present invention is provides the methods, uses and compositions useful in diagnosis of low-penetrance predisposition to human cancers of various sites wherein constitutional variants of alterations within CYP1B1 gene are analyzed in biological material from examined individual.... Agent: Cooper & Dunham, LLP
20070009915 - Microarray analysis of rna: In certain embodiments, the invention provides a method of performing an array analysis, the method including contacting a sample of RNA with an analogous DNA set to provide a DNA/RNA duplex, contacting the DNA/RNA duplex with an enzyme having a DNA:RNA nuclease activity to provide a digested RNA sample, and... Agent: Agilent Technologies Inc.
20070009938 - Minimalist bzip derivatives that bind to noncanonical gene regulatory sequences: The invention provides a method of specifically targeting noncanonical gene regulatory sequences using a minimalist basic region-leucine zipper bZIP derivative. Also provided are methods of modulating transcription and treating diseases and cancers using the minimalist basic region-leucine zipper bZIP derivatives.... Agent: Bereskin And Parr
20070009936 - Mtor kinase-associated proteins: The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening... Agent: Fish & NeaveIPGroup Ropes & Gray LLP
20070009931 - Negative correlation between irp-2 and transferrin receptor expression as a diagnostic of alzheimer's disease: A method of diagnosing Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) is disclosed which was identified by the fact that an increased level of iron regulating protein-2 (IRP-2) was identified in Alzheimer's patients. Further, diseases of increased cellular metabolism such as cancer showed high levels of both IRP-2 and... Agent: Knobbe Martens Olson & Bear LLP
20070009952 - Nephrin gene and protein: The present invention provides for compositions and methods for detecting susceptibility for basement membrane disease, in particular congenital nephrotic syndromes of the Finnish type. The present invention provides for nucleic acids and protein for use in methods and compositions for the diagnosis of disease and identification of small molecule therapeutics... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20070009912 - Novel ion channel preferentially expressed in mammalian taste receptor cells: Taste receptor polycystin-2L1 is provided. Methods and systems for screening for tastants and receptor modulators are provided. Knock out and transgenic animals, methods of detecting polymorphisms, and methods of correcting taste defects are also provided.... Agent: Quine Intellectual Property Law Group, P.C.
20070009900 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20070009901 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20070009902 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20070009903 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20070009904 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20070009905 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20070009906 - Nucleic acid and amino acid sequences relating to streptococcus pneumoniae for diagnostics and therapeutics: The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies against the polypeptides; and methods for the production of the polypeptides. The invention also provides methods for the detection, prevention and treatment of pathological conditions resulting... Agent: Hamilton, Brook, Smith & Reynolds, P.C.
20070009899 - Nucleic acid arrays for detecting gene expression in animal models of inflammatory diseases: The present invention provides nucleic acid arrays and methods of using the same for detecting gene expression in animal models of osteoarthritis or other inflammatory diseases. The nucleic acid arrays of the present invention comprise polynucleotide probes for genes that are differentially expressed in osteoarthritis-affected cartilage tissues as compared to... Agent: Nixon Peabody, LLP
20070009948 - Nucleic acid binding polypeptide library: The invention relates to a zinc finger polypeptide library in which each polypeptide comprises more than one zinc finger which has been at least partially randomized, and to a set of zinc finger polypeptide libraries which encode overlapping zinc finger polypeptides, each polypeptide comprising more than one zinc finger which... Agent: Townsend And Townsend And Crew, LLP
20070009907 - Nucleic acid ligands specific to immunoglobulin e and their use as atopic disease therapeutics: The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.
20070009889 - Nucleoside derivative, modifed oligonucleotide, method for their syntesis and applicantions thereof: New class of metallated nucleoside and nucleotide conjugates containing metallacarborane cage is provided, also oligonucleotides containing metallacarborane modification are disclosed. Nucleosides, nucleotides and oligonucleotides containing metallacarborane cage can be used among others as modified primers in amplification of RNA and DNA, antisense drugs, boron carriers for BNCT, radiopharmaceuticals bearing a... Agent: Nutter Mcclennen & Fish LLP
20070009894 - Oligonucleotide sequestering agents and method of use: The present application provides methods and compositions for use in detecting the presence of a target nucleic acid in a sample. In some embodiments, the methods employ sequestering agents which specifically interact with complementary nucleic acids which will be ligated together if the target nucleic acid is present in the... Agent: Knobbe Martens Olson & Bear LLP
20070009954 - Parallel polymorphism scoring by amplification and error correction: This invention provides a method of detecting polymorphisms, e.g., single nucleotide polymorphisms (SNPs), by amplification and error correction. The invention encompasses methods of performing amplification and error correction using an improved generation of nucleic acid polymerases, and methods of multiplexing the assay. The improvement to the polymerases is the joining... Agent: Townsend And Townsend And Crew, LLP
20070009949 - Paramyxovirus-derived rnp: A functional RNP containing negative-strand single-stranded RNA derived from Sendai virus, which has been modified so as not to express at least one envelope protein, has been successfully prepared. An RNP comprising a foreign gene is prepared and inserted into a cell with the use of a cationic liposome, thereby... Agent: Clark & Elbing LLP
20070009933 - Pgc-1beta, a novel pgc-1 homologue and uses therefor: The invention provides isolated nucleic acid molecules, designated PGC-1β nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1β nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in... Agent: Foley Hoag, LLP Patent Group, World Trade Center West
20070009939 - Preparation of nucleic acid samples: The presently claimed invention provides methods, compositions, and apparatus for studying nucleic acids Specifically, the present invention provides a novel enrichment and labeling strategy for ribonucleic acids In one embodiment, the invention provides enriching for a population of interest in a complex population by diminishing the presence of a target... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.
20070009910 - Primers, probes and reference plasmid for detection of meat adulteration: The present invention relates to a reference plasmid for use in specifically detecting the meat of pig, cattle, sheep, deer, horse and kangaroo. The reference plasmid can be used in rapidly identifying the species of meat and can be used in testing commercial meat products.... Agent: Husch & Eppenberger, LLC
20070009932 - Promoter engineering and genetic control: The present invention relates to expression cassettes libraries of expression vectors comprising the same, wherein each vector comprises at least one gene of interest and a promoter operatively linked thereto wherein each promoter comprises a nucleic acid, whose sequence is randomly mutated with respect to that of another in the... Agent: Pearl Cohen Zedek, LLP Pearl Cohen Zedek Latzer, LLP
20070009929 - Recombinant antigens for the detection of coxiella burnetii: The invention relates to a method for the detection of prior exposure to Coxiella. burnetii infection by antibody-based assays using recombinant, immunodominant C. burnetii polypeptides. The invention also relates to the design of biotin or His-tagged C. burnetii proteins useful in the antibody-based assays as standardized antigen reagents.... Agent: Naval Medical Research Center Attn: (code 00l)
20070009890 - Screen for novel protein inhibitors based upon engineered cell line containing an inducible overactivity gene and compensatory gene: The present invention provides a method for identifying the presence of a protein inhibitor of a target protein in a sample, comprising the steps of a) contacting said sample with a cell, wherein said cell contains i) an inducible lethal overactivity mutation in a gene affecting the target protein; and... Agent: Knobbe Martens Olson & Bear LLP
20070009945 - Single nucleotide polymorphisms associated with dose-dependent edema and methods of use thereof: The invention provides novel polynucleotides and polypeptides associated with the incidence of PPAR-agonist induced edema. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus per fragment. Allele-specific primers and probes which hybridize to these regions, and/or... Agent: Louis J. Wille Bristol-myers Squibb Company
20070009909 - Sorting of carbon nanotubes through arrays: A method is described that involves sorting CNT hybrid structures of differing sizes by passing the CNT hybrid structures through an arrangement of fixed structures. The sorting involves a diffusion component in which shorter CNT hybrid structures are scattered through the arrangement of fixed structures to a greater degree than... Agent: Blakely Sokoloff Taylor & Zafman
20070009947 - Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories: The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the common bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection... Agent: Knobbe Martens Olson & Bear LLP
20070009924 - Thermococcus zilligii dna polymerases and variants thereof: Native and variant Thermococcus zilligii DNA polymerases are disclosed, as are methods for using the same for nucleic acid synthesis, DNA sequencing, nucleic acid amplification and cDNA synthesis.... Agent: Invitrogen Corporation C/o Intellevate
20070009923 - Use of bayesian networks for modeling cell signaling systems: Methods of developing and using models of cellular networks by applying a probabilistic graphical model are provided.... Agent: Bozicevic, Field & Francis LLP
20070009963 - Apolipoprotein biopolymer marker indicative of normal human: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their... Agent: Mchale & Slavin, P.A.
20070009956 - Arginine hydrochloride enhances chaperone-like activity of alpha crystallin: The present invention provides that arginine, a biologically compatible molecule that is known to bind to the peptide backbone and negatively charged side-chains, increases the chaperone-like activity of a-crystallin significantly. Arginine, interestingly, restores the activity of mutant protein to a considerable extent. The invention shows the effect of arginine on... Agent: Morrison & Foerster LLP
20070009960 - Characterising polypeptides: Provided is a method for characterising an analyte by matrix assisted laser desorption ionisation (MALDI) mass spectrometry, which method comprises: (a) labelling the analyte with a light-absorbing label that absorbs light at a pre-determined frequency, to form a labelled analyte; (b) embedding the labelled analyte in a matrix formed from... Agent: Buchanan, Ingersoll & Rooney PC
20070009961 - Identification of targeting component of herbal medicines from simplified hplc spectrum using after flowing through immobilized receptor (aftir) method: A novel method of screening herbal composition for a pharmaceutically active component of interest (“target component”) comprises: immobilizing a plurality of receptors of interest on a chip; flowing the herbal composition through the chip to allow binding of the target component with the receptors; disassociating the bound target component from... Agent: Cohen, Pontani, Lieberman & Pavane
20070009959 - Methods for producing antibodies: The invention relates to a method of obtaining an antibody with a desired function, the method comprising: a) bringing a population of B cells into contact with a capturing agent; b) separating the captured B cells from the uncaptured B cells; c) culturing a plurality of captured B cells wherein... Agent: Woodcock Washburn LLP
20070009962 - Nucleic acid binding polypeptide library: The invention relates to a zinc finger polypeptide library in which each polypeptide comprises more than one zinc finger which has been at least partially randomized, and to a set of zinc finger polypeptide libraries which encode overlapping zinc finger polypeptides, each polypeptide comprising more than one zinc finger which... Agent: Townsend And Townsend And Crew, LLP
20070009955 - Secreted polypeptide species associated with cardiovascular disorders: The invention provides novel human secreted polypeptides comprising an amino acid sequence of SEQ ID NOS. I-10. The polypeptides of the invention circulate at an elevated level in the plasma of patients with cardiovascular disorders. The invention also provides compositions including the polypeptides, polynucleotides encoding them, and antibodies specific for... Agent: Novartis Corporate Intellectual Property
20070009958 - Support having selectively bonding substance fixed thereto: e
20070009957 - Vectors used to create hybrid constant regions: Expression vectors used for expression of mouse Fab libraries and expression of individual clones have portions of mouse constant regions replaced with human constant regions while maintaining desired cloning sites.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP
20070009966 - Method for identification of somatic stem cells: The invention relates to a method for identification of somatic stem cells, wherein the spatial arrangement of epitopes in a sample is captured by MELC technology for identifying the phenotype specific to the somatic stem cells. The invention moreover relates to a composition, a kit and a biochip comprising at... Agent: Womble Carlyle Sandridge & Rice, PLLC
20070009967 - Methods for shp1 mediated neuroprotection: The effect of EPO on the phosphorylation of the EPO receptor, the activation of the MAP Kinase pathway, and the expression of SHP-1 were analyzed. EPO was observed to cause a decrease in the expression of its negative regulator SHP-1. The decrease observed at both the mRNA and protein level... Agent: Philip S. Johnson Johnson & Johnson
20070009965 - Novel method for screening for gpcr agonists and/or antagonists from herbs: The present invention provides a novel method of using an herbal chip for screening for candidate compounds as a GPCR agonist or antagonist from herbs by using a labeled anti-GPCR-GPCR as a probe for hybridization.... Agent: Scully, Scott, Murphy & Presser
20070009964 - Ox40r binding agents: The present invention discloses peptides isolated from the extracellular domain of OX40 Ligand (OX40L) capable of binding OX40 Receptor (OX40R) and inhibiting OX40R-OX40L interaction. Such peptides, fusion proteins comprising them, as well as peptides and other molecules designed on their sequences, can be used as OX40R binding agents competing with... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association
20070009969 - Determination of pregnancy status: A method and kit for determining whether an animal is not pregnant, or is pregnant following a breeding. The level of expression of a pregnancy induced protein is determined in an animal for which pregnancy status information is desired and the level is compared to that of the level in... Agent: Howard Eisenberg, Esq.
20070009970 - Biological patterns for diagnosis and treatment of cancer: The present invention provides methods for diagnosing cancers, such as prostate cancer. Also, methods for evaluating the prostate cancer state of a patient are described herein. These methods involve the detection, analysis, and classification of biological patterns in biological samples. The biological patterns are obtained using, for example, mass spectrometry... Agent: Wilson Sonsini Goodrich & Rosati
20070009972 - Epidermal growth factor receptor polypeptides and antibodies: Antibodies and polypeptides that bind to and/or modulate the activity of receptors in the epidermal growth factor family are provided herein.... Agent: Fish & Richardson PC
20070009971 - Mammalian iap gene family, primers, probes, and detection methods: Disclosed is substantially pure DNA encoding mammalian IAP polypeptides; substantially pure polypeptides; and methods of using such DNA to express the IAP polypeptides in cells and animals to inhibit apoptosis. Also disclosed are conserved regions characteristic of the IAP family and primers and probes for the identification and isolation of... Agent: Philip A. Swain C/o Gowling Lafleur Henderson LLP
20070009973 - Method for screening candidate compounds for antitumor drug: Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in the blood cell lines revealed that the tyrosine residues in FLT3/ITD is constitutively phosphorylated in these cell lines and... Agent: Foley And Lardner LLP Suite 500
20070009975 - Method for detecting acid-resistant microorganisms in the stool: The invention relates to a method for detecting an infection of a mammal with an acid-resistant microorganism, wherein (a) a stool sample of a mammal is incubated with at least two different monoclonal antibodies, fragments or derivatives thereof or aptamers under conditions allowing a complex formation of antigens of the... Agent: Nixon Peabody, LLP
20070009974 - Methods and compositions to diagnose trichomonas infection: The present invention provides methods and compositions for diagnosing Trichomonas infection by detecting an antibody that specifically binds a Trichomonas α-actinin protein in a sample from a subject.... Agent: Myers Bigel Sibley & Sajovec
20070009968 - Photonic crystal biosensor structure and fabrication method: The invention provides sensor compositions and method of making sensors.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP
20070009976 - Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody: The present invention relates to the field of therapeutic antibodies. The invention especially relates to a method of detecting the target antigen of a therapeutic antibody in a sample comprising the steps of a) providing the sample to be analyzed, b) incubating said sample with said therapeutic antibody under conditions... Agent: Hoffmann-la Roche Inc. Patent Law Department
20070009979 - Cyclic gmp dependent protein kinase as a chemotherapeutic target for antiprotozoal agents: Protozoal cyclic GMP dependent protein kinases have been isolated and cloned. These enzymes may be used in screening assays to identify potential antiprotozoal agents.... Agent: Merck And Co., Inc
20070009977 - Kinase-directed, activity-based probes: Various embodiments of the present invention are related to kinase-directed, activity-based probes (“KABPs”) that bind to, and label, kinases. Each KABP includes a binding group that is recognized and bound by one or more kinases, a reactive group that tightly, and generally irreversibly, binds to the kinase, a tag group... Agent: Olympic Patent Works PLLC
20070009978 - Three part assay for kinase or phosphatase activity: The present invention relates to a method of determining kinase or phosphatase activity based on a three parts system. The method comprises contacting a binding partner which can bind phosphorylated peptides, a detection molecule and a substrate peptide. Determination of activities is achieved by measuring energy transfer between an energy... Agent: Hoffmann-la Roche Inc. Patent Law Department
20070009980 - Continuous fluorogenic analyte assays with dendritic amplification of signal: Substrate compounds comprising a trigger moiety, a reporter system comprising a plurality of fluorescent moieties, and a multivalent self-immolative dendrimer linker linking the trigger moiety to the reporter system.... Agent: Dechert LLP
20070009981 - Nematode phosphoethanolamine n-methyltransferase-like sequences: Nucleic acid molecules from nematodes encoding phosphoethanolamine n-methyltransferase polypeptides are described. PEAMT-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of PEAMT-like nucleotides and polypeptides. Also described are screening methods for identifying inhibitors and/or activators, as well as methods for antibody production.... Agent: Fish & Richardson PC
20070009982 - System for differential determination of a proteolytic enzyme level in a bodily fluid: The system includes an assortment (10) of sensors (10a, 10b, 10c), the working electrode (14a) of each sensor being covered with a specific reagent of a given proteolytic enzyme, including a substrate capable of releasing leaving groups (LG) via the action of said enzyme, a measuring apparatus (20) having an... Agent: Griffin & Szipl, PC
20070009983 - Pyridine nucleotide dehydrogenase based biosensor electrodes: The invention provides an electrode for the electrochemically reversible interconversion of the oxidised and reduced versions of a pyridine nucleotide comprising: an electrically conducting surface; an isolated pyridine nucleotide dehydrogenase module of an enzyme; wherein said isolated pyridine nucleotide dehydrogenase module is applied to the electrically conducting surface. The isolated... Agent: Dann, Dorfman, Herrell & Skillman
20070009984 - Churning methods for separating microorganisms from a food matrix for biodetection: A churning process with several variations that removes bacteria from food by mechanical means while adequately filtering the food matrix sufficiently for analysis in cytometer. Churning stirs, agitates, shakes, shears or compresses the food sufficiently to dislodge bacteria from food particles, without chopping, crushing, or cutting the food. In a... Agent: Jennifer L. Bales
20070009986 - Compositions for modulating immune cell activity and methods for detection thereof: The invention relates to a new method for measuring cytotoxic activity of immune cells, and to methods and products for treating abnormal immune responses.... Agent: Edwards & Angell, LLP
20070009987 - Dimer of chimeric recombinant binding domain-functional group fusion formed via disulfide-bond-bridge and the processes for producing the same: The present invention relates to a method producing dimer of chimeric recombinant binding domain-heterogeneous functional group fusion([B-F fusion]2) by using covalent disulfide-bond-bridge connecting the two monomers of chimeric recombinant binding domain-heterogeneous functional group fusion(B-F fusion). The dimer of chimeric recombinant binding domain(B)-heterogeneous functional group(F) fusion was the first to be... Agent: Lucas & Mercanti, LLP
20070009991 - Gene expression in transgenic avians: A recombinant nucleic acid is provided having an avian promoter. One embodiment of the present invention contemplates the use of a gut-specific promoter, wherein a promoter can be the chicken intestinal fatty acid binding protein promoter region. A method for making a transgenic bird is also disclosed by transfecting a... Agent: Avigenics, Inc.
20070009988 - Novel fungal proteins and nucleic acids encoding same: Disclosed herein are fungal nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The novel leucine aminopeptidase (LAP) and other amino- and carboxypeptidases polypeptides, referred to herein... Agent: Lahive & Cockfield, LLP
20070009985 - Novel nitrile hydratase: The amino acid sequence of a mutant which is obtained by introducing a novel mutation into a Pseudonocardia thermophila JCM3095-derived nitrile hydratase consisting of two types of heterogeneous subunits, and the base sequence of the gene are provided. The nitrile hydratase is modified by specifying the region to be modified... Agent: Buchanan, Ingersoll & Rooney PC
20070009990 - Site-specific incorporation of redox active amino acids into proteins: Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active... Agent: Quine Intellectual Property Law Group, P.C.
20070009989 - Synthetic heparanase molecules and uses thereof: The present invention relates to synthetically produced, enzymatically active heparanase nucleic acid molecules that are capable of expression in high yield heterologous expression systems, and to polypeptides encoded by said molecules. Also provided herein are methods of expressing mammalian heparanase in heterologous expression systems, wherein high yields of biologically active... Agent: Merck And Co., Inc
20070009992 - Variant tlr4 nucleic acid and uses thereof: The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.
20070009994 - Antigenic polypeptide se36 of malaria plasmodium, process for purification thereof, and vaccine and diagnostic agent using the antigen: The present invention provides a polypeptide SE36 derived from the N-terminal domain (47 kd) of SERA (serine-repeat antigen) produced by malaria parasite, Plasonodium falciparum, at the erythrocyte stage, a process for purifying said polypeptide, and a malaria vaccine and diagnostic agent using as an active component said purified antigen obtained... Agent: Wenderoth, Lind & Ponack, L.L.P.
20070009993 - Metrs2: The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infections in materials.... Agent: Swanson & Bratschun L.L.C.
20070009995 - Prevention of incorporation of non-standard amino acids into protein: The instant invention is drawn to the methods and compositions necessary to provide recombinant proteins with a substantially reduced or eliminated content of norleucine or other non-standard amino acids. Various embodiments of the invention provide for the substantial elimination of the incorporation of non-standard amino acids into recombinant proteins by... Agent: Howrey LLP
20070009996 - Ginkgo biloba levopimaradiene synthase: The present invention is directed to nucleic acid sequences of Ginkgo biloba diterpene synthases, particularly of a levopimaradiene synthase. More specifically, the invention is directed to a cell of a unicellular organism, such as Saccharomyces cerevisiae or Escherichia coli, comprising levopimaradiene synthase for the metabolically engineered in vivo biosynthesis of... Agent: Baker Botts L.L.P. Patent Department
20070009997 - Process for surface activation and/or devulcanisation of sulfur-vulcanized rubber particles: Process for surface activation and/or devulcanization of sulfur-vulcanized rubber particles. In order to break the sulfur bridges and to reduce the sulfur, the rubber particles are treated in a biotechnological manner in a medium with mesophilic anaerobic and/or optionally anaerobic and/or microaerophilic bacteria and/or with one or more enzyme systems... Agent: Workman Nydegger (f/k/a Workman Nydegger & Seeley)
20070009999 - Asymmetric reduction of 1,1,1-trifluoroacetone: The invention relates to a scalable biocatalytic process for the preparation of S-1,1,1,-trifluoro-2-propanol with a enantiomeric excess of >99% by asymmetric microbial reduction of 1,1,1 -trifluoroacetone with Baker's yeast.... Agent: Hoffmann-la Roche Inc. Patent Law Department
20070010000 - Cholesterol oxidase stable in the presence of surfactant: A novel cholesterol oxidase having stability in the presence of surfactant and a gene encoding the novel cholesterol oxidase.... Agent: Greenblum & Bernstein, P.L.C
20070010001 - Production of bacteriophage compositions for use in phage therapy: The present invention relates to the use of bacteriophages to treat infections diseases. The invention provides a method for intermediate to large scale commercial production of bacteriophage composition, wherein the method reduces the production volume and elevates production yield. The invention further relates to improved bacteriophage compositions comprising specific sugars... Agent: Heslin Rothenberg Farley & Mesiti PC
20070010002 - Method and device for cultivating eucaryotic microorganisms or blue algae, and biosensor with cultivated eucaryotic microorganisms or blue algae: The invention relates to a method and device for cultivating eukaryotic microorganisms, whereby a perforated support (14) having a first major surface (19) and a second major surface (22) which is substantially impermeable to eukaryotic microorganisms (20), is prepared and the microorganisms (20) are applied on the first major surface... Agent: Shumaker & Sieffert, P. A.
20070010003 - Ferment activator based on lactic acid bacteria, and method of preparing a product using said activator: The present invention relates to an activator for a lactic bacteria-based ferment, characterised in that it comprises at least: one reducing disaccharide, one non-reducing disaccharide, an alkaline metal salt and/or an alkaline earth metal salt. The invention also relates to the ferment which is activated by means of said activator.... Agent: Marshall, Gerstein & Borun LLP
20070010004 - Micellar systems: Methods are described for modifying nucleic acids to facilitate delivery of the nucleic acids to cells. Compounds which interact with of modify nucleic acids are interacted with the nucleic acids within reverse micelles.... Agent: Mirus Corporation
20070010005 - Neonatal support system and related devices and methods of use: In certain embodiments, the present invention relates to a life support system and related devices and systems and methods of use for such devices and systems. In some of these embodiments, the invention relates to a support system for a neonate or fetus and related methods of use of such... Agent: Naman, Howell, Smith & Lee
20070010006 - System and method for detecting biohazardous threats: A system and method for detecting a mailpiece contaminated by hazardous agents/materials including at least one contaminant sensor for detecting the presence of a hazardous agent/material and a Radio Frequency Identification (RFID) device in communication with the contaminant sensor. The contaminant sensor issues an alert signal to the RDIF device... Agent: Pitney Bowes Inc. 35 Waterview Drive
20070010007 - Sample processing device compression systems and methods: Sample processing systems and methods of using those systems for processing sample materials located in sample processing devices are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include a cover and compression... Agent: 3m Innovative Properties Company
20070010008 - Ex vivo expansion of primary animal cells: An ex vivo method of expanding animal cells whose differentiation state is controllable by modulating TGF-β signaling includes the steps of: (a) providing an animal subject having cells with a first phenotype; (b) isolating the cells from the animal subject; (c) placing the cells in an ex vivo culture system... Agent: Wilson Sonsini Goodrich & Rosati
20070010009 - Antibody composition-producing cell: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for... Agent: Nixon & Vanderhye, PC
20070010011 - Defined media for pluripotent stem cell culture: Stem cells, including mammalian, and particularly primate primordial stem cells (pPSCs) such as human embryonic stem cells (hESCs), hold great promise for restoring cell, tissue, and organ function. However, cultivation of stem cells, particularly undifferentiated hESCs, in serum-free, feeder-free, and conditioned-medium-free conditions remains crucial for large-scale, uniform production of pluripotent... Agent: Woodcock Washburn LLP
20070010012 - Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells: The present application describes the new methods for the differentiation of primate pluripotent stem cells into cardiomyocyte-lineage cells. The methods utilize sequential culturing of the primate pluripotent stem cells in certain growth factors to produce cardiomyocyte-lineage cells. In certain embodiments of the invention, the population of cells produced by the... Agent: Geron Corporation
20070010010 - Method for efficient transfer of human blastocyst-derived stem cell (hbs cells) from a feeder-supported to a feeder-free culture system: A method for the transfer of human blastocyst-derived stem cells (hBS cells) to feeder-free culture system and propagation of the cells in such a feeder-free culture system, the method comprising the following steps of (a) transferring the balstocyst-derived stem cells from feeder to feeder free culture by mechanical treatment, (b)... Agent: Buchanan, Ingersoll & Rooney PC
20070010013 - Oocytes derived from ovarian culture initially containing no oocytes: Ovarian germ-line-competent embryonic stem cells (GLC-ESC) are cultured, either in the presence or absence of a compound having estrogenic activity. The GLC-ESC are either collected prior to specific commitment or are permitted to remain in the culture medium for a time sufficient to develop into oocytes, and the oocytes may... Agent: Howard Eisenberg, Esq.
20070010014 - Compositions and methods for enhanced delivery to target sites: A set of compositions that includes an active agent-labeled species and a pretargeting conjugate is disclosed. The active agent-labeled species includes a first oligomeric nucleotide or mimic thereof conjugated to a first moiety coupled with a diagnostic active agent. The pretargeting conjugate includes a second oligomeric nucleotide or mimic thereof... Agent: General Electric Company Global Research
20070010015 - Complete empty viral particles of infectious bursal disease virus (ibdv), production method thereof and applications of same: Whole empty viral particles of infectious bursal disease virus (IBDV), which contain all of the antigenically-relevant proteinaceous constituents present in determinant IBDV virions. The whole empty virus particles are readily produced in suitable expression systems to provide capsids that can be used in the production of vaccines against avian disease,... Agent: Klarquist Sparkman, LLP
20070010016 - Gene transfer with adenoviruses having modified fiber proteins: Methods and compositions for transducing tumor cells using adenoviral vectors which comprise: a chimeric or modified adenovirus fiber protein and the coding sequence for a therapeutic agent, are provided. The chimeric or modified adenovirus fiber protein has at least a portion of an adenovirus fiber shaft of a first serotype... Agent: Dla Piper Rudnick Gray Cary LLP Suite 800
20070010017 - Lentiviral packaging constructs: The present invention provides novel lentiviral packaging constructs that are useful for the establishment of stable packaging cell lines and producer cell lines. In particular, the present invention provides novel packaging cell lines that are capable of constitutively expressing high levels of lentiviral proteins.... Agent: Bell, Boyd, & Lloyd LLC
20070010018 - Methods of screening for introduction of dna into a target cell: The present invention provides methods of introducing a polynucleotide into a target cell, wherein the method employs a light generating protein coding sequence acting as a reporter. An important advantage of the methods described herein is that drug resistant target cells or target cells having no useful auxotrophic markers can... Agent: Robins & Pasternak01/04/2007 > 152 patent applications in 41 patent subcategories. USPTO class patent listing
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