Chemistry: molecular biology and microbiology inventions 12/06

20060292544 - Systems, methods, compositions and solutions for perfusing an organ: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20060292546 - Herg channel-expressing cell: It is an object of the present invention to establish a method of establishing a cell with a remarkably high hERG channel expression level for use in predicting adverse effects based on hERG channel inhibition in research and development of drugs, and to thereby establish a highly sensitive and high... Agent: Darby & Darby P.C.

20060292547 - Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism: Chronic alcoholism is a diverse and heterogeneous disorder that can be dichotomized into cognitively intact and cognitively impaired subgroups. At a molecular level, ethanol has been shown to have both acute and chronic effects on: Membrane biophysical properties, Membrane composition and metabolism, Protein phosphorylation, Lipid metabolic signaling, Lipoprotein transport of... Agent: Lesavich High-tech Law Group, P.C.

20060292550 - Method for determining fish composition using bioelectrical impedance analysis: A method for determining the freshness of fish. The method includes applying electrodes to the fish, passing an electrical current between the electrodes, determining an impedance for tissue of the fish between the electrodes, and correlating the determined impedance with a freshness value to determine the freshness of the fish.... Agent: Alex Nolte

20060292545 - Moleculary imprinted polymers for extraction of components from foodstruffs: The present invention relates to a novel class of water compatible molecularly imprinted polymers (AquaMIPs) capable of selectively binding target molecules such as riboflavin, or analogues thereof, in water or aqueous media, their synthesis and use thereof in food processing and extraction or separation processes.... Agent: Young & Thompson

20060292549 - Psychotropic drug screening device based on long-term photoconductive stimulation of neurons: The invention pertains generally to the field of psychotropic drug discovery and neuroscience. More specifically, the invention refers to a device that allows the long-term stimulation of cultured neurons grown on a silicon die, thereby replacing the use of intact animal models. The device consists of a controlled sterile environment... Agent: Fish & Richardson P.C.

20060292548 - Trp8, a transient receptor potential channel expressed in taste receptor cells: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion... Agent: Nixon Peabody LLP - Patent Group

20060292551 - Anti-viral activity of cathelicidin peptides: The disclosure provides methods and compositions useful in the treatment of dermatitis and viral infections. The compositions comprise cationic peptides of the cathelicidin family including LL-37, related homologues, and variants thereof.... Agent: Buchanan, Ingersoll & Rooney LLP

20060292555 - Biofunctional magnetic nanoparticles for pathogen detection: This invention provides a method of detecting pathogens comprising the steps of: (a) contacting a sufficient amount of biofunctional magnetic nanoparticles with an appropriate sample for an appropriate period of time to permit the formation of complexes between the pathogens in the sample and the nanoparticles; (b) using a magnetic... Agent: Law Offices Of Albert Wai-kit Chan, LLC

20060292559 - Cell-based microarrays, and methods for their preparation and use: The present invention is in the field of chemistry and biotechnology. The present invention relates to cell-based microarrays, improved methods for forming such arrays, and methods for using such arrays in diagnostics, therapeutics and research. The invention particularly concerns microarrays in which ligands of a target cells are immobilized to... Agent: Edell, Shapiro & Finnan, LLC

20060292554 - Major coat protein variants for c-terminal and bi-terminal display: The invention provides compositions and methods for enhanced display of heterologous proteins on viral particles.... Agent: Merchant & Gould PC

20060292553 - Method for study of the genetic and functional variability of hiv and kit for using it: A method of analyzing a sample possibly containing an HIV virus, including a) extracting viral RNA in a biological sample that possibly contains an HIV virus; b) reverse transcription of the RNA obtained of (a) and amplification with a first pair of primers to obtain an amplified product of reverse... Agent: Ip Group Of Dla Piper US LLP

20060292552 - Method for the detection and multiplex quantification of analytes in a sample, using microspheres: The invention relates to a method for the detection and multiplex quantification of analytes in a sample, using functionalised microspheres, whereby said microspheres are magnetised after the sample has been brought into contact therewith. The inventive method is particularly suitable for the detection and multiplex quantification of several analytes by... Agent: Foley And Lardner LLP Suite 500

20060292556 - Method of detecting antibodies to hcv: A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBV), but which are absent from individuals infected with hepatitis A virus, or hepatitis B virus, and also are absent in... Agent: Novartis Vaccines And Diagnostics Inc.

20060292558 - Methods and apparatus for protein assay diagnostics: Automated protein assay apparatus and methods for measuring antibodies against an analyte are described. A standard mixture of one or more analytes is loaded into a capillary, the analytes are resolved by isoelectric focusing and immobilized in the capillary. Serum from a human or non-human subject under analysis is flowed... Agent: Roger O'neill Cell Biosciences

20060292557 - Methods and compositions for detecting herpes simplex virus type 2: The invention provides methods for sensitive and specific detection of anti-HSV-2 antibodies by depletion of cross-reactive (non-specific) antibodies in a biological sample that can lead to a false positive result. The invention also features compositions, including nucleic acids, polypeptides, and kits, for use in the methods of the invention.... Agent: Bozicevic, Field & Francis LLP

20060292585 - Analysis of methylation using nucleic acid arrays: Methods of analyzing DNA to determine the methylation status of a plurality of cytosines are disclosed. In one aspect genomic DNA is fragmented, fragments are circularized, the circles are treated with a methylation sensitive enzyme to enrich for circles with methylated sites or with a methylation dependent enzyme to enrich... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20060292607 - Analysis of tissue samples surrounding malignancies: The present invention provides a method for analyzing tissue from the surgical margin of resected tumor, and the use of such information to predict recurrence, survival, and treatment efficacy in cancer patients. Methods of treatment based thereon are provided.... Agent: Fulbright & Jaworski L.L.P.

20060292618 - Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance: The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to... Agent: Kilpatrick Stockton LLP - M0351

20060292622 - Application of aprataxin gene to diagnosis and treatment for early-onset spinocerebellar ataxia (eaoh): The present invention provides polynucleotides and proteins, which are involved in early-onset spinocerebellar ataxia with ocular motor apraxia and hypoalbuminemia (EAOH); and methods of using the polynucleotides and/or proteins to treat and/or diagnose EAOH.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20060292588 - Assay systems, kits and methods for detecting microorganisms: The present invention relates to an assay system, kits and methods for detecting microorgansims (especially for M. tuberculosis) of suspected patient. The present invention also relates to an apparatus for performing the integration of thermal and magnetic control in the same apparatus to largely reduce the whole process of M.... Agent: Bruce H. Troxell

20060292574 - Automated vntr genotyping method: The invention provides an automated VNTR genotyping method using multiple variable-number tandem repeats (VNTRs) loci based on mycobacterial interspersed repetitive units (MIRU) undergoing multiplex PCR and high throughput MegaBACE® capillary electrophoresis system. The method uses fluorescent dyes of 6-carboxytetramethylrhodamine(TAMRA), 6-carboxy fluorescein (FAM) and 6-carboxy-2′,4,4′,5′,7,7′-hexachlorofluorescein (HEX) labeling PCR primers. The method... Agent: Birch Stewart Kolasch & Birch

20060292581 - Biosensor for small molecule analytes: A biosensor device for detecting small molecules analytes is provided. The device employs a first class of molecules, e.g., protein that binds to both the analyte and a second class of molecules, e.g., nucleic acid. The binding of the protein to the analyte and nucleic acid can be mutually exclusive,... Agent: Darby & Darby P.C.

20060292572 - Cell-type-specific patterns of gene expression: Among the methods, compositions, combinations and kits provided herein are those for determining gene expression levels in one or more cell types in heterogeneous cell samples, for identifying genes differentially expressed in different cell types, and for detecting a cell type in a sample from a subject. Also provided herein... Agent: Fish & Richardson, PC

20060292580 - Cleavage of nucleic acids: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a... Agent: Medlen & Carroll, LLP

20060292596 - Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens: A method of preventing or inhibiting infection by a parasite or virus in vivo comprising administering to a human in need thereof a parasite or virus mitogen in a sub-mitogenic amount sufficient to induce a protective immune response against the parasite or virus in the human.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060292598 - Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens: A method of preventing or inhibiting infection by a parasite or virus in vivo comprising administering to a human in need thereof a parasite or virus mitogen in a sub-mitogenic amount sufficient to induce a protective immune response against the parasite or virus in the human.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060292608 - Comparative genomic hybridization: Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially removed and/or their hybridization signals suppressed. The invention termed Comparative... Agent: Quine Intellectual Property Law Group, P.C.

20060292584 - Compositions and methods for accomplishing nucleotide depletion: Methods and compositions are provided that achieve depletion of a nucleotide pool by means of a phosphate-transferring enzyme such as a nucleoside phosphate or a polyphosphate glucokinase. Depletion of a nucleotide pool using a nucleoside kinase may additionally utilize a phosphotransferase in a second phosphate-transferring reaction.... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20060292615 - Compositions and methods for detecting single gene copies in-situ: Compositions and methods are provided for detecting single copies of a gene in-situ using brightfield microscopy in detection of various target nucleic acid sequences, such as genes or nucleic acid of microorganisms in a cell. In particular, nucleic acid probes for various target nucleic acid sequences in a cell are... Agent: Wilson Sonsini Goodrich & Rosati

20060292604 - Compositions and methods for spinocerebellar ataxia: The autosomal dominant spinocerebellar ataxias (SCAs) represent a growing and heterogeneous clinical phenotype with ongoing discovery of causative etiologies. Methods: The authors collected DNA and clinically characterized a three-generation Filipino family segregating a dominant ataxia. Following elimination of several known SCA loci, a genome-wide linkage study was undertaken with additional... Agent: Jones Day

20060292628 - Compositions and methods involving direct write optical lithography: An improved optical photolithography system and method provides predetermined light patterns generated by a direct write system without the use of photomasks. The Direct Write System provides predetermined light patterns projected on the surface of a substrate (e.g., a wafer) by using a computer controlled means for dynamically generating the... Agent: Affymetrix Inc/ Attn: ChiefIPCounsel Legal Dept

20060292593 - Dendritic cell co-stimulatory molecules: A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and... Agent: Banner & Witcoff

20060292602 - Dna diagnostic screening for turner syndrome and sex chromosome disorders: The present invention encompasses methods, assays and kits for the diagnosis, screening and identification of Turner syndrome and other disorders of sexual differentiation in a human using single nucleotide polymorphisms present on the X and Y chromosomes.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20060292561 - Dna enzymes: Methods for the selection of novel signaling allosteric DNA enzymes are provided. In particular, fluorescent signaling allosteric DNA enzymes are described. The selection system is based on the cleavage of an ribonucleotide flanked by a fluorophore modified nucleotide and a quencher modified oligonucleotide. Both cis-acting and trans-acting allosteric DNA enzymes... Agent: Summa, Allan & Additon, P.A.

20060292578 - Dna polymerase blends and mutant dna polymerases: A thermostable DNA polymerase composition comprising at least two DNA polymerases, one of which is substantially reduced in 5′-exonuclease activity and one of which has 5′-exonuclease activity. This polymerase may be used in methods including, but not limited to, nucleic acid synthesis, DNA sequencing, nucleic acid amplification and cDNA synthesis,... Agent: Invitrogen Corporation

20060292595 - Electrochemiluminescence detection method for nucleic acid using intercalator: Disclosed is a method for detecting nucleic acid hybridization by using intercalator binding to hybridized nucleic acid, wherein oxidation-reduction of transition metallic complex is induced to cause electrochemiluminescence, thereby providing a method for detecting nucleic acid hybridization without a special labeling.... Agent: Fleshner & Kim, LLP

20060292589 - Fluorescent quenching detection reagents and methods: Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group.... Agent: David W. Parker

20060292591 - Genes from the 20q13 amplicon and their uses: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.... Agent: Beyer Weaver & Thomas, LLP

20060292620 - Genes with es cell-specific expression: The present invention relates to a probe for selecting ES cells, which characteristically contains one of DNAs having base sequences depicted in SEQ ID Nos; 1, 2, 3, 4, 5, 6, 7 and 8, or DNAs having base sequences depicted in SEQ ID Nos; 9, 11, 13, 15, 17, 19,... Agent: Leydig Voit & Mayer, Ltd

20060292594 - Hdac inhibitors that promote brm expression and brm related diagnostics: The present invention provides screening methods for identifying BRM expression-promoting histone deacetylase (HDAC) inhibitors, diagnostic methods for determining the suitability of treatment of a candidate subject with a BRM expression-promoting HDAC inhibitor, and therapeutic methods for treating cancer cells in a patient with a BRM expression-promoting HDAC inhibitor. The present... Agent: Medlen & Carroll, LLP

20060292583 - High speed parallel molecular nucleic acid sequencing: A method and device is disclosed for high speed, automated sequencing of nucleic acid molecules. A nucleic acid molecule to be sequenced is exposed to a polymerase in the presence of nucleotides which are to be incorporated into a complementary nucleic acid strand. The polymerase carries a donor fluorophore, and... Agent: Klarquist Sparkman, LLP

20060292573 - Human orthologues of wart: The present invention relates in part to hWART nucleic acid molecules. The invention also relates in part to nucleic acid molecules encoding portions of hWART full-length proteins, nucleic acid vectors containing hWART nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to... Agent: Foley And Lardner LLP Suite 500

20060292586 - Id-tag complexes, arrays, and methods of use thereof: The present invention relates to the detection of target sequences. Detection can be achieved through the use of ID-tag complexes. These ID-tag complexes are relatively stable in the absence of a target sequence. In the presence of a target sequence, the complexes dissociate and form new complexes or duplexes, which... Agent: Knobbe Martens Olson & Bear LLP

20060292606 - Identification of ligands by selective amplification of cells transfected with receptors: The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions. The present invention also relates to a method of identifying compounds which act as inverse agonists of the 5-HT2A receptor, the method comprising contacting a constitutively... Agent: Knobbe Martens Olson & Bear LLP

20060292609 - Interferon-beta gene therapy using an improved, regulated expression system: The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and... Agent: Foley And Lardner LLP Suite 500

20060292592 - Key probe compositions and methods for polynucleotide detection: The invention relates to compositions and methods for detection of nucleic acid sequences. The invention further relates to kit format of said compositions for detection of nucleic acid sequences. Oligonucleotide probes of the invention comprise a target binding sequence and a sequence at least partially complementary thereto, joined by an... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20060292619 - Method and algorithm for quantifying polynucleotides: Machine executable method of analyzing growth curve data to identify the transition from a baseline phase into a growth phase. Applications of the method include analysis of results from time-dependent monitoring of amplicon synthesis in a nucleic acid amplification reaction to quantify a starting amount of a nucleic acid template... Agent: Gen Probe Incorporated

20060292567 - Method and means for determining specific conditions or changes in the uterine epithelium and in the epithelium of other organs: In a method for determining specific conditions or changes in the endometrium or in the epithelium of other organs, RNA from a blood sample or tissue sample isolated and the expression or over expression of mRNA of at least one of β7-hCG, β6-hCG, and β6e-hCG is measured quantitatively in the... Agent: Gudrun E. Huckett Draudt

20060292564 - Method and nucleic acids for the analysis of breast cell proliferative disorders: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of breast cell proliferative disorders,... Agent: Davis Wright Tremaine, LLP

20060292605 - Method for highly sensitive nucleic acid detection using nanopore and non-specific nucleic acid-binding agent: Provided is a method of sensitively detecting nucleic acids in a nucleic acid sample, the method comprising: contacting the sample comprising the nucleic acid with a non-specific nucleic acid binding agent in an electrically conductive fluid medium; contacting the sample comprising the nucleic acid bound to the agent with a... Agent: Cantor Colburn, LLP

20060292566 - Method for optimising gene expressing using synonymous codon optimisation: The present invention discloses a method for modulating the quality of a selected phenotype that is displayed by an organism or part thereof and that results from the expression of a polypeptide-encoding polynucleotide by replacing at least one codon of that polynucleotide with a synonymous codon that has a higher... Agent: Heller Ehrman White & Mcauliffe LLP

20060292603 - Method for selecting a chemical entity from a tagged library: Disclosed is a method for determining the identity of a chemical entity having a preselected property. The chemical entity is identified from a library composed of a plurality of different chemical entities each appended to unique identifier tags. An anti-tag having the capability of specifically interacting with the unique identifier... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20060292569 - Method for selectively binding a substrate to sorbents by way of at least bivalent bonds: A method for the manufacture of at least one sorbent having at least two different groups, which are capable of binding, for the selective binding of a substrate, characterized in that it comprises the steps (i) to (ii): (i) determining at least two groups capable of binding a sorbent from... Agent: Stephen D Scanlon Jones Day

20060292612 - Method for the quality control of functionalized surfaces: The invention relates to a method which can be used to test firstly a reaction and secondly the distribution of functional groups on a surface. This method is employed in a situation that demands documentation or testing of a distribution of surface functionalization, which is as homogeneous as possible.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20060292568 - Method of preparing dna fragments and applications thereof: The invention relates to a method of preparing DNA fragments and to the applications thereof, in particular for the hybridisation of nucleic acids. The inventive method is essentially characterised in that it consists of at least the following steps comprising: (a) preparation of double-stranded DNA fragments from a sample of... Agent: Lowe Hauptman Berner, LLP

20060292617 - Methods and compositions for analysis of microrna: The invention provides methods and systems for detecting and measuring microRNAs.... Agent: Wolf Greenfield & Sacks, PC

20060292613 - Methods and compounds for prevention and treatment of elevated intraocular pressure and related conditions: A GPCR-like protein is described, as well as inhibitory/antagonistic compounds and compositions comprising such inhibitors/antagonists of the protein. Such compounds may be used for treating elevated intraocular pressure and conditions associated with elevated intraocular pressure, such as glaucoma.... Agent: Darby & Darby P.C.

20060292597 - Methods for genotyping with selective adaptor ligation: The present invention provides methods for reducing the complexity of a nucleic acid sample to interrogate a collection of target sequences. Complexity reduction can be accomplished by fragmenting the nucleic acid sample with a restriction enzyme that has at least one variable position in the recognition sequence. In some aspects... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20060292582 - Methods for nucleic acid manipulation: A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity... Agent: Welsh & Katz, Ltd

20060292624 - Methods for the electrochemical detection of multiple target compounds: A method of detecting two different target molecules through a single electrode is carried out by (a) providing a conductive oxidation-reduction reaction detection electrode; (b) contacting a sample suspected of containing a first and second target molecule to the electrode under conditions in which the first and second target molecules... Agent: Myers Bigel Sibley & Sajovec

20060292626 - Methods of analysis of allelic imbalance: Methods are provided for identification of genes that are imprinted. In another embodiment methods are provided for identification and analysis of genes whose expression shows allelic imbalance. The expression products transcribed from genes that are present in the genome as two or more alleles may be distinguished by hybridization to... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20060292565 - Methods of cardiovascular disease assessment in an individual: Methods for cardiovascular disease assessment in an individual comprise detecting the presence or absence of a fragment encoding a polymorphic alpha-2C (α2C DEL322-325) adrenergic receptor in a sample from an individual; and detecting the presence or absence of a fragment encoding a polymorphic beta-1 adrenergic receptor (β1Arg389) in a sample... Agent: Dinsmore & Shohl, LLP

20060292563 - Methods of diagnosing & treating diabetes and insulin resistance: The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels... Agent: Townsend And Townsend And Crew, LLP

20060292579 - Methods of enzymatic discrimination enhancement and surface bound double-stranded dna: Methods for discriminating between fully complementary hybrids and those that differ by one or more base pairs and libraries of unimolecular, double-stranded oligonucleotides on a solid support. In one embodiment, the present invention provides methods of using nuclease treatment to improve the quality of hybridization signals on high density oligonucleotide... Agent: Townsend And Townsend And Crew LLP

20060292614 - Methods of gene expression monitoring: The invention provides methods of monitoring expression of a plurality of genes in a cell or small population of cells. Preferred methods entail contacting an array of probes with a population of nucleic acids derived from a population of fewer than 1000 cells then determining the relative hybridization of the... Agent: Banner & Witcoff Ltd., Counsel For Affymetrix

20060292562 - Methods of identifying genomic and proteomic biomarkers for cystic fibrosis, arrays comprising the biomarkers and methods of using the arrays: Cystic fibrosis (CF) is the most common fatal autosomal recessive disease in the U.S. and is principally caused by the DF508 mutation the CFTR gene. The principal site of morbidity and mortality for this disease is the lung. We have used genomic and proteomic methods to identify ubiquitin carboxy terminal... Agent: Dla Piper US LLP Attn: Patent Group

20060292599 - Methods to detect lineage-specific cells: The present invention is based, at least in part, on methods to identify and quantify lineage-specific cells. The present invention provides methods of detecting lineage-specific cells in a biological sample, and monitoring the effectiveness of progenitor cell transfer in a subject. The invention further provides methods of determining an effective... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20060292600 - Methods, compositions and kits for the detection and monitoring of lung cancer: Compositions and methods for the diagnosis of lung cancer are disclosed. Such methods are useful to detect early tumors or provide adequate stage/grade information or tumor specificity. Compositions may comprise one or more lung tumor proteins, teins, immunogenic portions thereof, or polynucleotides that encode such portions. Such compositions may be... Agent: Seed Intellectual Property Law Group PLLC

20060292577 - Neoplasia-specific splice variants and methods: All neoplastic cells express a unique cell-surface ubiquinone (NADH) oxidase with protein disulfide-thiol isomerase with characteristic sensitivity to inhibition by capsaicin, sulfonylureas, adriamycin and certain other compounds. This neoplasia-specific protein is the translational expression production of a particular splice pattern: exon 4 is not translated to become part of the... Agent: Greenlee Winner And Sullivan P C

20060292590 - Nod nucleic acids and polypeptides: The present invention relates to the NOD proteins and nucleic acids encoding the NOD proteins. The present invention further provides assays for the detection of NOD polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NOD proteins.... Agent: Medlen & Carroll, LLP

20060292576 - Non-in situ hybridization method for detecting chromosomal abnormalities: The present invention provides methods of detecting chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases. In particular, the present invention provides advanced methods of performing DNA hybridization, capture, and detection on solid support. Invention methods are useful for the detection, diagnosis, predicting response to... Agent: Foley & Lardner LLP

20060292625 - Novel human leucine-rich repeat domain containing protein hllrcr-1: The present invention provides novel polynucleotides encoding HLLRCR-1 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLLRCR-1 polypeptides to the diagnosis, treatment, and/or prevention... Agent: Louis J. Wille Bristol-myers Squibb Company

20060292575 - Novel method for diagnosing pathogens of sexually transmitted diseases: The present invention provides a novel method for diagnosing various pathogens of sexually transmitted diseases from one test sample. The method comprises amplifying the DNA fragments of the various pathogens synchronously by using one primer set and identifying the amplified DNA fragments with specific probes. This invention also provides a... Agent: Troxell Law Office PLLC One Skyline Place

20060292570 - Novel synthetic binding pairs and uses thereof: Derivatized cucurbiturils can be efficiently prepared and utilized for forming cucurbituril assemblies. These cucurbituril assemblies, in turn, can form affinity binding pairs with polyamines structures that are designed capable of binding to these assemblies. The resulting affinity pairs are highly advantageous over the presently known affinity pairs and therefore can... Agent: Martin D. Moynihan Prtsi, Inc.

20060292611 - Paired end sequencing: The present invention provides for a method of preparing a target nucleic acid fragments to produce a smaller nucleic acid which comprises the two ends of the target nucleic acid. Specifically, the invention provides cloning and DNA manipulation strategies to isolate the two ends of a large target nucleic acid... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20060292627 - Pb39, a gene dysregulated in prostate cancer, and uses thereof: A novel gene, PB39, that is up-regulated, or over-expressed, in prostate cancer has been identified. The gene has been identified by means of its cDNA obtained by reverse transcription of the corresponding mRNA. Microdissection of prostate glands that had been surgically removed from prostate cancer patients revealed a novel up-regulated... Agent: National Institutes Of Health C/o Venable LLP

20060292587 - Polynucleotides encoding insect voltage-gated chloride channel and uses thereof: The instant invention provides nucleic acids encoding insect chloride channel (CLC channel), as well as CLC channel polypeptides encoded thereby. The invention further provides methods of identifying agents that modulate a level of CLC channel mRNA, polypeptide, or calcium ion channel activity. Such agents are candidate insecticidal compounds.... Agent: Bozicevic, Field & Francis LLP

20060292610 - Prognostic meta signatures and uses thereof: The present invention relates the novel statistical analyses of gene expression data. In particular, the present invention provides prognostic meta signatures (e.g. representing cancer samples) that identify genes with altered expression across several studies.... Agent: Medlen & Carroll, LLP

20060292571 - Quantification schemes for quantifying nucleic acids: Method and apparatus, including computer program products, implement techniques for quantifying a target nucleic acid (target) in a test sample. The techniques include providing a target and a defined initial amount of an internal control nucleic acid (control) different from the target; amplifying the target and control in a common... Agent: Roche Molecular Systems Inc Patent Law Department

20060292621 - Randomized libraries of zinc finger proteins: The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes.... Agent: Robins & Pasternak

20060292601 - Rapid genotyping analysis and the device thereof: The present invention discloses the use of Allele-Specific-oligonucleotide (ASO) as a detection assay for human HLA classification. Using Reversed-Dot-Blotting format and flow through hybridization process, more efficient, faster and less expensive HLA classification can be achieved. A simplified procedure for HLA genotyping is also described. This invention further provides a... Agent: Law Offices Of Albert Wai-kit Chan, LLC

20060292623 - Signature genes in chronic myelogenous leukemia: The present invention relates to genetic markers whose expression is correlated with progression of CML. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate chronic phase individuals from those in blast crisis. The invention relates to methods of using these markers to distinguish these... Agent: Jones Day

20060292616 - Single molecule mirna-based disease diagnostic methods: The invention relates to compositions and methods for detecting and quantifying small RNA species such as miRNA, preferably associated with disease detection and diagnosis.... Agent: Wolf Greenfield & Sacks, PC

20060292560 - Transcription factor target gene discovery: The ability to rapidly define transcription factor target genes allows for the study of genetic cascades involved in development, physiology and disease. The presently descibed invention outlines the combination of novel chromosomal immunoprecipitation and molecular biology technologies fot the high-throughput in vico discovery and characterization of both known and unknown... Agent: Transgenetics, Inc.

20060292637 - Biomimetic systems consisting of lipid membranes bound to an electrically conducting substrate: The invention concerns lipids functionalized with a terminal C═C double bond which can be transformed into an anchor group for binding to a substrate surface. The invention further concerns lipids comprising such an anchor group for binding to a substrate surface. The invention also concerns self-assembled monolayers of lipids on... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20060292630 - Biosensor and method of analyte measuring: A biosensor capable of analyzing an object, such as antigen, antibody, DNA or RNA, through detection of magnetic field to thereby allow washout of unbound label molecules to be unnecessary, which biosensor is compact and available at low price, excelling in detection precision. Coils are arranged at an upper part... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060292629 - Chimeric polypeptides and their use: The present invention concerns chimeric molecules that contain a preferential polypeptidic region, consisting of a specific affinity for the binding to specific DNA sequences, of a preferential polypeptidic region consisting of a DNA modifying activity, and this chimeric molecule is capable to cross biological membranes due to the presence of... Agent: Ladas & Parry

20060292631 - Elastin peptide fingerprints and analysis methods for mmp12 related to copd: Methods for producing and using protein/peptide fingerprints, allowing identification and investigation of disease-associated proteins/peptides that can be linked to specific drug targets, or to specific drug target combinations. The methods are particularly useful for studies relating to Chronic Obstructive Pulmonary Disease (COPD), especially for the enzyme MMP12.... Agent: Fish & Richardson P.C.

20060292632 - Method for ascertaining the orientation of molecules in biological specimens: A method of ascertaining the orientation of molecules in a biological specimen by total internal reflection includes focusing illuminating light through an objective in different positions in a plane of a pupil of the objective so as to generate a plurality of respective differently oriented evanescent fields in the specimen.... Agent: Darby & Darby P.C.

20060292633 - Method for modulating process mediated by farnesoid activated receptors: Farnesyl pyrophosphate, the metabolically active form of farnesol, is a key precursor in the synthesis of cholesterol, carotenoids, steroid hormones, bile acids and other molecules involved in cellular growth and metabolism. A nuclear receptor has been identified that is transcriptionally activated by farnesol and related molecules. This novel signaling pathway... Agent: Foley & Lardner LLP

20060292636 - Monoclonal antibodies, hybridoma cell lines, methods and kits for detecting phytase: This invention relates to the field of immunology and more specifically relates to anti-phytase monoclonal antibodies, immunoassay methods, kits, and reagents, for the detection of a phytase from or derived from E. coli phytase, in particular, Quantum™ phytase. The invention further relates to hybridoma cell lines that produce anti-phytase monoclonal... Agent: Syngenta Biotechnology, Inc. Patent Department

20060292638 - Sequence #115 as a target for identifying weight modulating compounds: Sequence #115, a G protein-coupled receptor, has been identified as a target for identifying weight modulating compounds. Compounds that modulate sequence #115 may be useful for the treatment of obesity and cachexia. Cell-based and cell-free assays are described to identify compounds which bind to and/or activate or inhibit the activity... Agent: Hoffmann-la Roche Inc. Patent Law Department

20060292635 - Stably preserved microspheres: In accordance with the present invention, active carboxylic acid ester groups are coupled on the surfaces of microspheres so as to reduce protocols for microsphere processing, control side reactions, and stably preserve beads containing active carboxylic acid ester groups. Further, microspheres labeled with at least one fluorescent dye cage in... Agent: Reed Smith LLP

20060292634 - Structure for presenting desired peptide sequences: Means and methods for generating binding peptide associated with a suitable core region are disclosed, the resulting proteinaceous molecule and uses thereof. A solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of... Agent: Trask Britt

20060292640 - Diagnostic methods for the detection of risk of neurodevelopmental disorders: The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD,... Agent: Townsend And Townsend And Crew, LLP

20060292639 - Splice variant of the vanilloid receptor vr1a: The invention provides a splice variant of the vanilloid receptor termed “VR1A.” VR1A has a unique N-terminus as compared with wild type VR1. The invention provides nucleic acid sequences encoding VR1A, expression vectors for expressing VR1A, amino acid sequences of VR1A, antibodies against VR1A and methods of making and using... Agent: Woodcock Washburn LLP

20060292645 - Method and reagent for measuring kinase activity: A method of measuring the activity of a kinase to which imatinib mesylate can bind is described. In the method, a kinase contained in a sample, to which imatinib mesylate can bind, a substrate for the kinase, and ATP are mixed. A phosphate group of ATP is thereby transferred to... Agent: Brinks Hofer Gilson & Lione

20060292644 - Novel tumor-associated marker: The present invention provides monoclonal antibody-producing hybridomas designated 27.F7 and 27.B1. The invention provides a method of detecting TIP-2 antigen bearing cancer cells in a sample. The invention provides a method of detecting TIP-2 antigen on the surface of cancer cells. The invention provides a method for diagnosing cancer in... Agent: Cooper & Dunham LLP

20060292643 - Recognition molecules for the treatment and detection of tumours: The invention relates to recognition molecules directed towards tumors, and it also relates to pharmaceutical compositions comprising said recognition molecules, methods for the production of said recognition molecules, and to the use of said recognition molecules in the diagnosis and therapy of tumor diseases.... Agent: Millen, White, Zelano & Branigan, P.C.

20060292646 - Methods, biosensors, and kits for detecting and identifying fungi: Described herein are methods of detecting the presence or absence of fungi, for example, fungi growing on a sample, by contacting the sample with a substrate which is modified at least one fungal compound that is produced and/or secreted by the fungus. The substrate's modification, or lack thereof, indicates the... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20060292648 - Method of screening for inhibitors of osteopontin: Amino acids 136 to 142 and amino acids 162 to 168 of human osteopontin constitute two sites at which osteopontin interacts with α4 integrins. Products capable of disrupting those interactions are useful in therapy, particularly in the treatment of inflammatory diseases.... Agent: Glaxosmithkline Corporate Intellectual Property - Uw2220

20060292647 - Reflex supplemental testing - a rapid, efficient and highly accurate method to identify subjects with an infection, disease or other condition: The present disclosure concerns methods, compositions and apparatus for detecting pathogens and/or molecular markers. In a particular embodiment, the pathogen to be detected may be Mycobacterium bovis or any other Mycobacterium species that causes tuberculosis in a mammal. However, the disclosed methods are not limited and virtually any type of... Agent: Faegre & Benson LLP Patent Docketing

20060292641 - Immunoassay method: The present invention provides an immunoassay method easier in operation and smaller in fluctuation of reaction. The immunoassay method according to the present invention is an immunoassay method, which employs a sandwich method using a microchip having an antibody immobilized in the micro-flow channel thereof, comprising feeding a fluid mixed... Agent: Smith, Gambrell & Russell

20060292642 - Immunoassay of phosphorylated proteins: An immunoassay of phosphorylated isoforms (phosphoforms, phosphoisoforms) of peptides, proteins, or their various related forms is described. In one embodiment, a sandwich-type “two-site” immunoassays involving two different recognition antibody partners, in which one antibody is specific for the protein or peptide and the other is specific for a known or... Agent: Beckman Coulter, Inc.

20060292649 - Methods and apparatus for reference lab diagnostics: Automated protein assay apparatus and methods suitable for use in a reference lab are described. A screening test for a pathogen or disease condition is performed at the reference lab. If the results of the screening test are positive, a definitive assay is performed. One or more analytes are resolved... Agent: Roger O'neill Attn: Cell Biosciences

20060292650 - Spectroscopic analysis of a biological fluid reacted with an enzyme: An apparatus is presented for estimating the concentration of an analyte using a combined enzyme-spectroscopic method. Examples are provided for the detection of glucose and lactate. A sample of biological fluid is mixed or contacted with an enzyme specific to the analyte of interest, and the reacting fluid is probed... Agent: Knobbe Martens Olson & Bear LLP

20060292653 - Metal mediated fluorescence superquenching assays for detection of phosphorylation and dephosphorylation of quencher-labeled substrates: A method includes contacting an analyte; a phosphorylatable or dephosphorylatable substrate bound to a quencher; and a sensor that includes at least one fluorescent polymer complexed to one or more metal species; to form a composition; and determining the fluorescence of the composition, if any; wherein when the substrate is... Agent: Dla Piper US LLP Attn: Patent Group

20060292654 - Microwell plate: The shallower wells of a crystalisation plate in which it is intended to form crystals are part-spherical and of uniform wall thickness. The optical effect of the transparent plastics material from which the plate is moulded counter the distortion of a view through a microscope so that crystals viewed through... Agent: Akerman Senterfitt

20060292651 - Protein labelling with oº-alkylguanine-dna alkyltrnsferase: The present invention relates to methods of transferring a label from suitable substrates to O6-alkylguanine-DNA alkyltransferase (AGT) fusion proteins, to suitable fusion proteins, to suitable variants of AGT, and to novel labelled fusion proteins obtained. A protein of interest is incorporated into an AGT fusion protein, the AGT fusion protein... Agent: Wenderoth, Lind & Ponack, L.L.P.

20060292652 - Substrate detection assay: Methods and compositions for evaluating nicotinamide-releasing activities as well as cell and organism-based evaluation methods are provided herein.... Agent: Fish & Richardson PC

20060292655 - 2-o sulfatase compositions and methods of analyzing therewith: The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present... Agent: Wolf Greenfield & Sacks, PC

20060292656 - Lactamase amplification substrate: An amplifiable β-lactamase substrate is provided comprising an enzyme donor fragment of β-galactosidase linked to form a ring to a β-lactam ring that is a substrate for lactamase and upon opening of the β-lactam ring the enzyme donor fragment becomes linearized. The cyclic substrate only weakly binds to the enzyme... Agent: Peters Verny Jones & Schmitt, L.L.P.

20060292658 - Fluorescent compound: A water-soluble photoluminescent compound including a symmetrical skeletal structure of the formula (A) in which x may represent any integer, and in which the phenyl rings may be substituted, is disclosed. A protein detector comprising such a compound and a method of measuring the total dissolved protein content of a... Agent: Young Law Firm, P.C. Alan W. Young

20060292657 - Phex substrates and methods using same: A fluorogenic PHEX substrate comprising a peptide unit; a fluorophore unit capable of conferring fluorescence on said substrate attached to an amino acid residue at a first end of the peptide unit; and a quencher unit capable of providing intrarnolecular quenching of said fluorescence attached to an amino acid residue... Agent: Choate Hall & Stewart Patent Group

20060292660 - Preparations for diagnosis of pancreatic exocrine function: A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into the blood and/or is excreted out of the body, wherein the substance is carried by a carrier and released from... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060292659 - Protease regulator screening assay: A polypeptide containing an anchor region, a protease recognition site, and a detectable signal region can be produced recombinantly and directly attached to a solid support. The polypeptide is useful for screening protease regulators, especially protease inhibitors.... Agent: Novartis Vaccines And Diagnostics Inc.

20060292661 - Electrochemical sensing assays involving drug metabolizing enzymes: Use of an electrochemical mediator to transfer electrons from an electrode to molecules of a mammalian oxidative drug metabolizing enzyme (DME) in solution is described, in particular to carry out assays to determine metabolism of a candidate drug by the DME. Transfer of electrons by the mediator is carried out... Agent: Heller Ehrman White & Mcauliffe LLP

20060292662 - Galleria mellonella derived composition for detecting peptidoglycan, a method for use thereof, and a diagnostic kit containing the same: The present invention relates to a composition for selectively detecting an extremely small amount of peptidoglycan in sample, a preparation method of the composition, and a detection kit for peptidoglycan. It is possible to quantify a small amount of peptidoglycan contained in human blood, tissue, body fluid, water or food,... Agent: Gifford, Krass, Groh, Sprinkle & Citkowski, P.c

20060292663 - Method of measuring lactate dehydrogenase activity in serum, and device for measuring lactate dehydrogenase activity in serum: A new electrochemical measurement method is provided that is excellent in accuracy in detecting LDH activity in a serum sample and shortens the time required for the detection. The method of measuring lactate dehydrogenase activity in serum includes: a first step (S1) of adding at least lactic acid, a coenzyme... Agent: Mcdermott Will & Emery LLP

20060292664 - Method and apparatus for detecting and quantifying bacterial spores on a surface: A method and an apparatus for detecting and quantifying bacterial spores on a surface. In accordance with the method: bacterial spores are transferred from a place of origin to a test surface, the test surface comprises lanthanide ions. Aromatic molecules are released from the bacterial spores; a complex of the... Agent: Alessandro Steinfl, Esq. C/o Ladas & Parry

20060292665 - Glutaryl amidases and their uses: The invention relates to a new class of isolated, single or multiple mutated glutaryl amidases from Pseudomonas SY-77, or a functional part, derivative or analogue thereof. The invention also relates to a method for preparing 7-aminocephalosporanic acid from cephalosporin C, using a glutaryl amidase according to the invention. The invention... Agent: Trask Britt

20060292666 - Fermentation method for the preparation of testolactone by fusarium species: The present invention relates to a microbial method for the simultaneous dehydrogenation and oxidation of 4-an-drosten-3,17-dione to produce 17a-oxo-D-homo-1,4-andrustadiene-3,17-dione in high yield and high substrate concentrations, by means of filamentous Fusarium species.... Agent: Pfizer Inc

20060292667 - Method for improving solubility and folding efficiency of target proteins using rna as molecular chaperone: Disclosed is a method for improving folding efficiency and solubility of a target protein linked to a RNA-binding protein by using RNA molecule as a molecular chaperone, wherein the RNA molecule interacts with the RNA-binding protein. More particularly, the present invention discloses method for improving folding efficiency and solubility of... Agent: Lucas & Mercanti, LLP

20060292672 - Cell lines for expressing enzyme useful in the preparation of amidated products: Cell lines are provided for expressing peptidylglycine alpha-amidating monooxygenase (PAM), or one of its two catalytic domains. High levels of enzyme expression are achieved while utilizing a non-animal source, low protein tissue culture medium. A robust two-step downstream purification results in high enzyme purity. Resulting PAM, or its PHM catalytic... Agent: Ostrolenk Faber Gerb & Soffen

20060292669 - Mammalian prickle gene: The present invention provides the mPrickle gene which encodes a protein present in mammalian PSD fractions. The mPrickle protein is localized in synapses, and binds to the scaffold protein PSD-95. Precipitation of endogenous mPrickle using an anti-mPrickle antibody results in the coprecipitation of NMDA receptors, and thus, mPrickle can be... Agent: Townsend And Townsend And Crew, LLP

20060292671 - Mannitol induced promoter systems in bacterial host cells: The present invention provides methods for producing recombinant peptides in a bacterial host utilizing a mannitol, arabitol, glucitol, or glycerol-inducible promoter, wherein the host bacterial cell that produces the peptide has been rendered incapable of degrading or metabolizing mannitol, arabitol, or glucitol, or derivatives or analogues thereof. The present invention... Agent: King & Spalding LLP

20060292670 - Nell peptide expression systems and bone formation activity of nell peptide: The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone formation. This invention also provides methods for the expression and purification of NELL1 and NELL2 peptides.... Agent: Squire, Sanders & Dempsey L.L.P.

20060292668 - Nuclear factor of activated t cell receptor: Novel nuclear factor of activated T cells (“NFAT”) activating receptor useful for producing agonist and antagonist antibodies that regulate the cellular production and expression of cytokines and cellular receptors. The receptor is a 270 amino acid type I transmembrane protein with a calculated molecular mass of about 30 kD. The... Agent: Cheryl Liljestrand Tanox Inc

20060292673 - 2-o sulfatase compositions and methods of degradation therewith: The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present... Agent: Wolf Greenfield & Sacks, PC

20060292674 - Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20060292675 - Process for producing fatty acids: A process for producing fatty acids, which comprises supplying an oil phase substrate and a water phase substrate to an enzyme column packed with an immobilized enzyme, concurrently flowing them in the same direction, and hydrolyzing a fat and/or oil, wherein the oil phase substrate and the water phase substrate... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20060292676 - Method for the producing vanillic acid and vanillin from waste residue of rice bran oil by fermentation and biotransformation: A method for the production of vanillic acid and vanillin from waste residue (niger) of rice bran oil by microbial fermentation and biotransformation is provided. The method of the present invention comprises the steps of hydrolization of ferulic acid esters in waste residue of rice bran oil to ferulic acid... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20060292677 - Use of corn with low gelatinization temperature for production of fermentation-based products: The present invention provides a method of producing fermentation-based products, such as ethanol and citric acid, from corn in which the starch has a low gelatinization temperature, particularly a waxy maize plant which is homozygous or heterozygous for the recessive sugary-2 allele.... Agent: National Starch And Chemical Company

20060292678 - Gluconobacter oxydans 2-ketoreductase enzyme and applications thereof: This invention relates to an novel Gluconobacter oxydans 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding G. oxydans 2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated G. oxydans... Agent: Louis J. Wille Bristol-myers Squibb Company

20060292679 - Beer containing monascus-derived pigments: Beers and processes for the production thereof are provided in accordance with the present invention, in which Monascus—derived pigments are employed as natural (i.e. non-synthetic) colorants.... Agent: James W. Kerr Inbev S.a.

20060292680 - Affinity membrane for capture of a target biomolecule and formation thereof by site-directed immobilization of a capture biomolecule: Compositions and methods are taught for directing the orientation of an immobilized capture biomolecule on a hydrophobic membrane. The method comprises layering at least one tie layer on a hydrophobic membrane, adding an amine functional layer on top of at least one tie layer; and attaching an alignment biomolecule to... Agent: Jonathan E. Grant

20060292681 - Method for designing modulators of flexible multi-domain protein kinases: The present invention describes novel methods of designing protein kinase modulators, particularly modulators that interact at the interface between two protein kinase domains. In some embodiments, the methods comprise determining the position of at least one site between the first domain and the second domain, wherein the modulator binds to... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20060292682 - Addition of transgenes into adenoviral vectors: Adenoviral vectors are provided that contain a transgene inserted in the viral genome at a novel site such that one or more of native processing, regulatory signals or heterologous transcription signals such as branch point sites, splice acceptor sites, internal ribosome entry sites, self-processing cleavage sites and/or polyA signals contribute... Agent: Dla Piper Rudnick Gray Cary US LLP Patent Group

20060292683 - Cross-beta structures on microbial organisms: The present invention discloses the use of a protease inhibitor in the preparation of a medicament for the treatment of microbial infections. The invention further discloses the use of a compound binding to a cross-β structure or an antibody specific for a cross-β structure in the preparation of a medicament... Agent: Trask Britt

20060292684 - Method and system for treating oxidized contaminant-containing matrix: A new and useful way of treating oxidized-contaminant-containing water, soil, rock, other geological or non-geological matrix formation (such as a landfill) is provided. A bioreactor is provided that includes elemental sulfur and a microbial population capable of oxidizing sulfur and reducing pertechnate (TcO4−), arsenate (H2AsO4−), chromate (CrO42−), bromate (BrO3−), chlorite... Agent: Lawrence R. Oremland, P.C.

20060292685 - Method of sustained microbial production of hydrogen gas in a bioreactor utilizing an equalization tank: The present invention provides a method of hydrogen production from microorganisms, wherein a bioreactor provides an environment conducive to the production of hydrogen from hydrogen producing microorganisms and restrictive to the production of methane from methanogens. The method further includes an equalization tank that provides improved control of flow rates,... Agent: Eckert Seamans Cherin & Mellott

20060292686 - Analyte recovering device, and analyte recovering method: An analyte recovering device which supplies an analyte solution containing an analyte to a flow path including a substantially flat face on which a ligand is attached, for binding the ligand and the analyte in the analyte solution with each other, and recovering the bound analyte is provided. The device... Agent: Sughrue Mion, PLLC

20060292687 - Methods for modulating floral organ identity, modulating floral organ number, increasing of meristem size, and delaying flowering time: This invention is directed to plant genetic engineering. In particular, it relates to, for example, modulating seed (and in particular endosperm, embryo and seed coat) development, flowering time, chromosomal DNA methylation and modulating transcription in plants.... Agent: Townsend And Townsend And Crew, LLP

20060292689 - Car receptor as a mediator of migratory cell chemotaxis and/or chemokinesis: This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing... Agent: Edwards & Angell, LLP

20060292690 - Method of making cell growth surface: The present invention discloses a three-dimensional porous growth surface made from polysaccharide material, especially the alginic acid, to enhance cell growth surface, promote cell adherence, immobilization and propagation, maintain surface structure integrity, enable programmable degradation, and thus increase cellular production. The present invention teaches several methods: a method to enhance... Agent: Birch Stewart Kolasch & Birch

20060292692 - Potentially regenerative cells and functional tissue-organs in vitro: Compositions and methods are provided for culturing in vitro potentially regenerative cells (PRCs) from which functional tissue-organs are regenerated. In one aspect of the invention, a tissue culture medium is provided which comprises at least 50% of water and a sterol compound that is dissolved in a fatty acid-containing oil... Agent: Wilson Sonsini Goodrich & Rosati

20060292691 - Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina): The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20060292688 - System and sequential culture media for in vitro fertilization: Instead of immersing human reproductive cells in a single culture medium throughout the various procedures used in IVF, a process is provided by which the reproductive cells may be moved through a sequence of distinct culture media as the various IVF procedures are carried out. In one implementation, the culture... Agent: Foley & Lardner LLP

20060292693 - Monoclonal antibody with the capability of neutralizing enterovirus type 71 infection: The present invention provides a monoclonal antibody capable of neutralizing EV71 infection.... Agent: Cohen, Pontani, Lieberman & Pavane

20060292695 - Methods and kits for drug screening and toxicity testing using promoter-reporter cells derived from embryonic stem cells: This invention provides a system for rapid determination of pharmacologic effects on target tissue types in cell populations cultured in vitro. The cells contain a promoter-reporter construct that reflects a toxicologic or metabolic change caused by the agent being screened. The promoter is taken from a gene known to be... Agent: Geron Corporation

20060292694 - Reporter hepatocytes and other cells for drug screening and toxicity testing: This invention provides a system for rapid determination of pharmacologic effects on target tissue types in cell populations cultured in vitro. The cells contain a promoter-reporter construct that reflects a toxicologic or metabolic change caused by the agent being screened. The promoter is taken from a gene known to be... Agent: Geron Corporation

20060286544 - Establishment of a human embryonic stem cell line using mammalian cells: Purified preparations of human embryonic stem cells with certain population-specific characteristics are disclosed. This preparation is characterized by the positive expression of the following pluripotent cell surface markers: SSEA-1 (−); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+); alkaline phosphatase (+), as well as a set of ES cell markers including Oct-4,... Agent: Vinson & Elkins, L.L.P.

20060286552 - Direct quantification of gene expression using capillary electrophoresis with laser-induced fluorescence: Provided is a method for direct quantification of gene expression using capillary electrophoresis with laser-induced fluorescence to measure RNA in a sample. Also provided is a method of diagnosing a disease in a subject, wherein the disease is caused by increased or decreased expression of a causative gene.... Agent: Needle & Rosenberg, P.C.

20060286546 - Method and kit for the quantitative and/or qualitative detection of components in a sample: A method and kit for quantitatively and/or qualitatively detecting one or more components in samples, including the use of metal-particle labelled reagents and an antibody conjugate are disclosed. The components are capable of binding to a probe. A kit and method for staining components in cell and tissue sections, based... Agent: Knobbe Martens Olson & Bear LLP

20060286548 - Method of making recombinant human antibodies for use in biosensor technology: According to the current invention and apparatus and methods are provided for the production of modified antibodies and calins for use in biosensor applications.... Agent: Gtc Biotherapeutics, Inc, C/o Wolf, Greenfield & Sacks, P.C.

20060286549 - Microfluidic system for identifying or sizing individual particles passing through a channel: An apparatus for characterizing and identifying individual particles, including: an input reservoir; at least one output reservoir; a channel connecting the input reservoir to the at least one output reservoir, wherein the channel is functionalized with at least one molecule selected to interact with a marker on a surface of... Agent: Gordon & Rees LLP

20060286551 - Rt-pcr detection for differential diagnosis of field isolates or lapinized vaccine strain of classical swine fever virus (csfv) in samples: The present invention provides a rapid RT-PCR detection method and a diagnostic kit for differentiating field isolates of classical swine fever virus (CSFV) from lapinized CSF vaccine viruses in samples. In order to detecting different genotypes of CSF virus, this invention uses a pair (or pairs) of CSF virus specific... Agent: Pai Patent & Trademark Law Firm

20060286550 - Substrates for isolating, reacting and microscopically analyzing materials: An immobilizing device for biological material comprises a rigid support (12) carrying a substrate layer (20, 20′) of polymer having biological immobilizing properties, e.g. for amino and nucleic acids. Substantially solid ultra-thin substrate layers (20′) having a thickness less than about 5 micron, preferably between about 0.1 and 0.5 micron,... Agent: Fish & Richardson PC

20060286547 - Time-of-addition assay for identifying anti-viral compounds: The present invention relates to a multi-well assay for identifying a compound inhibiting the replication cycle of a micro-organism, for example, HIV, and to an apparatus for carrying out an assay according to the present invention. The invention further relates to compounds identifiable with an assay according to the invention... Agent: Philip S. Johnson Johnson & Johnson

20060286545 - Viral vectors with improved properties: Methods to improve the tropism or other features of a virus is disclosed. Such methods can be used to prepare, e.g., DNA or plasmid libraries of variants of a gene encoding a viral capsid or envelope restriction site, libraries of viral clones with such variant genes with a randon-dy inserted... Agent: Darby & Darby P.C.

20060286563 - Analytical method and device utilizing magnetic materials: The present invention relates to an analytical method and device utilizing magnetic materials and acoustics sensor. The invention employs a magnetic material modified with specific recognizable molecules to capture a substance in a sample and provides an external magnetic field to draw the magnetic material to an sensing region of... Agent: Bacon & Thomas, PLLC

20060286597 - Aortic carboxypeptidase-like polypeptide: The invention features a aortic carboxypeptidase-like polypeptide (ACLP), DNA encoding ACLP, and methods of detecting genetic alterations associated with abdominal wall defects.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20060286592 - Candida kefyr cytosine deaminase: A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme.... Agent: Jenkens & Gilchrist

20060286590 - Cis-regulatory modules: A process for identifying a cis-regulatory module including aligning a target sequence with at least one sequence from a moderately distant species; determining a non-coding region of the target sequence, wherein the non-coding region comprises at least one of a high level of conservation and a suppression of indels; and... Agent: Min, Hsieh & Hack LLP

20060286557 - Combined lysis and pcr buffer: The present invention provides compositions, methods, and kits for lysing cells, storing nucleic acids, amplifying nucleic, and analyzing nucleic acids. Among other things, the compositions, methods, and kits are suitable for one-step lysis and amplification of nucleic acid sequences of interest. In general, the compositions comprise TCEP and a non-ionic... Agent: LatimerIPLaw, LLP

20060286574 - Compositions and methods for enhancing drug sensitivity and treating drug resistant infections and diseases: The present invention provides compositions useful in treating drug-resistant microorganisms and cells, as well as related methods of identifying and using such compositions. In addition, the present invention includes compositions useful in enhancing the sensitivity of both drug-resistant and drug-sensitive microorganisms and cells to microbicidal and cytotoxic agents, including antibiotics... Agent: Quine Intellectual Property Law Group, P.C.

20060286584 - Compositions and methods for the regulation of cell proliferation and apoptosis: The present invention includes compositions and methods for the detection, characterization, diagnosis and kits related to the modification of transcriptional factors of the YAP signaling pathway and their correlation with oncogenesis.... Agent: Chalker Flores, LLP

20060286566 - Detecting apparent mutations in nucleic acid sequences: A target nucleic acid sequence information obtained from a biological sample can be compared against a collection of reference nucleic acid sequences. The target nucleic acid sequence is aligned or matched against the reference sequences, wherein some of the target sequences have one or more polymorphisms. Different collections of reference... Agent: Edwards & Angell, LLP

20060286578 - Detection of 5t4 rna in plasma and serum: This invention provides methods for detecting the presence of malignant or premalignant cells, or trophoblastic cells in a human wherein the malignant, premalignant or trophoblastic cells express 5T4. The methods of the invention detect 5T4 RNA in blood, blood plasma, serum, and other bodily fluids. The inventive methods are useful... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20060286594 - Detection of antidepressant induced mania: Methods and kits for assessing the susceptibility of a patient to antidepressant-induced mania are described. The method involves testing a sample from a patient for the presence of the s variant of the 5HTTLPR polymorphism in the 5HTT gene. The presence of this s variant indicates that the patient is... Agent: Bereskin And Parr

20060286554 - Fluid container for electrohydrodynamic spray device and method of using same: A fluid container (6) for use with an electrohydrodynamic spray device (1) and method of using the device (1) are provided. The container (6) comprises at least one reservoir configured for holding a sprayable liquid, at least one interface (23) in fluid communication with the reservoir, at least one manifold... Agent: Dennis Kilfoil

20060286588 - Genetic variants in the tcf7l2 gene as diagnostic markers for risk of type 2 diabetes mellitus: Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility to diabetes and protection against diabetes, are described, as are methods of treatment for type II diabetes.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20060286581 - Heteroconfigurational polynucleotides and methods of use: Methods, compositions and kits are disclosed that utilize heteroconfigurational polynucleotide comprising a D-form polynucleotide sequence portion and an L-form polynucleotide sequence portion that is covalently linked to the D-form polynucleotide sequence portion.... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20060286568 - Identification of a gene associated with spinocerebellar ataxia type 5 and methods of use: The present invention provides methods that include analyzing an SCA5 polynucleotide, and determining whether the SCA5 polynucleotide includes a mutation. The methods may be used to identify a subject that is at risk or not at risk for developing spinocerebellar ataxia type 5. The present invention also provides isolated polynucleotides... Agent: Mueting, Raasch & Gebhardt, P.A.

20060286598 - Isolated cel ii endonuclease: The present invention relates to the isolation and characterization of CEL I and CEL II endonuclease proteins. Methods and kits for identifying mismatches in double-stranded DNA are also provided.... Agent: Licata & Tyrrell P.C.

20060286556 - Lymphoid chemokines in the diagnosis, monitoring and treatment of inflammatory disease: Experimental autoimmune encephalomyelitis (EAE) is a Th1-mediated autoimmune disease of the central nervous system that is widely used as an animal model of multiple sclerosis (MS). In this study it was demonstrate that CXCL13, a chemokine involved in the development of secondary lymphoid tissues, is expressed in CD11c+ myeloid cells... Agent: Fish & Richardson P.C.

20060286575 - Mcl-1 quadruplex nucleic acids and uses thereof: A biologically significant quadruplex structure in the MCL-1 regulatory region has been discovered. Certain mutations in quadruplex forming nucleotide sequences alter quadruplex structure and are associated with cancer and perhaps other diseases. Thus, provided herein are MCL-1 quadruplex nucleic acid acids, cancer diagnostics and prognostics, methods for using the cancer... Agent: Morrison & Foerster LLP

20060286596 - Method and apparatus for separating and purifying biopolymers: The present invention separates and purifies a negatively charged target biopolymer from among biological samples without involving fluid movements. In other words, a first solution containing said biological samples and a second solution for preserving a separated and purified biopolymer are partitioned by a gel, thereby allowing said target biopolymer... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20060286573 - Method for determining nucleotide sequence of nucleic acid molecule by utilizing scanning probe microscope: A nucleotide sequence of a single-stranded nucleic acid molecule immobilized on a substrate is determined with an SPM by analyzing a shape of bases constituting the single-stranded nucleic acid molecule by scanning over a nucleic acid chain of the single-stranded nucleic acid molecule immobilized on the substrate with a probe... Agent: Fitzpatrick Cella Harper & Scinto

20060286553 - Method for forming self-assembly substance using oligonucleotide synthesized by gene amplification reaction, self-assembly substance and method for detecting gene: There is provided a method for forming a self-assembly substance using oligonucleotides without using special instruments or complicated procedures, an self-assembly substance formed by the method for forming the self-assembly substance, and a method for detecting an amplified target gene at a low cost and in a simple way by... Agent: Wenderoth, Lind & Ponack, L.L.P.

20060286572 - Method for producing chemically synthesized and in vitro enzymatically synthesized nucleic acid oligomers: A method is described for producing chemically synthesized and in vitro enzymatically synthesized oligomer and other nucleic acid molecules which are associated with less nucleotide sequence damage than prior art chemically synthesized and biologically synthesized oligomers and other nucleic acid molecules, along with the use of such improved oligomers and... Agent: Wesley B. Ames

20060286589 - Method of screening multiple single nucleotide polymorphisms associated with susceptibility to specific disease or drug response: Provided is a method of screening multiple single nucleotide polymorphisms (SNPs) having significance with a case group, the method comprising: selecting one or more SNPs from nucleic acid sequences of the case group and a control group; generating all combinable genotype patterns of multiple SNPs comprised of two or more... Agent: Cantor Colburn, LLP

20060286586 - Method to diagnose or screen for inflammatory diseases: The invention relates to the field of medical diagnostics. More specifically, the invention relates to methods to diagnose or screen for inflammatory conditions or disease, including auto-inflammatory disease and affective disorder, in a subject, preferably a human subject, by assaying for a marker for an inflammatory disease. Provided is a... Agent: Trask Britt

20060286569 - Method, apparatus, and system for authentication using labels containing nucleotide sequences: A method, label, and labeling system for labeling and authenticating an item are presented. At least one of a number of known nucleotide sequences associated with a predetermined amount of information is used as a label to be associated with an item. The label is then read with a reagentless... Agent: Schneck & Schneck

20060286591 - Methods and compositions for expressing negative-sense viral rna in canine cells: The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make... Agent: Johnathan Klein-evans

20060286595 - Methods and compositions for the detection of cervical disease: Methods and compositions for identifying high-grade cervical disease in a patient sample are provided. The methods of the invention comprise detecting overexpression of at least one biomarker in a body sample, wherein the biomarker is selectively overexpressed in high-grade cervical disease. In particular claims, the body sample is a cervical... Agent: Alston & Bird LLP

20060286576 - Methods and nucleic acids for the analyses of cellular proliferative disorders: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for... Agent: Davis Wright Tremaine, LLP

20060286577 - Methods for detection of methylated dna: The present invention provides methods for improving the efficiency of methylation detection. The present invention provides improvements from current technologies via increased efficiency of template denaturation and bisulfite conversion reaction, also significant time savings in sample preparation, recovery, as well as increased efficiency of desulfonation. These methods facilitate rapid analysis... Agent: Jonathan Claypool Suite 30

20060286585 - Methods for diagnosing epigenetic, transgenerational effects of environmental toxicants on mammalian germ-lines and treating associated diseases: The present invention provides methods for detecting epigenetic, multigenerational DNA alterations caused by toxicants such as endocrine disruptor agents in a subject. The practice of the present invention can be used to diagnose and/or treat a subject having the identified DNA alterations by developing therapeutics, to prevent or delay the... Agent: Mandel & Adriano

20060286562 - Methods for purifying dna polymerases: The present invention provides methods and kits for obtaining substantially pure DNA polymerases. The methods comprise fractionating preparations comprising at east one DNA polymerase using Poly U Sepharose chromatography and obtaining substantially pure DNA polymerase. The present invention also provides compositions comprising substantially pure archaebacterial DNA polymerase obtained by fractionation... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060286587 - Methods for quantitative analysis of a nucleic acid amplification reaction: Methods for quantitating an initial amount of a target nucleic acid in a sample which has been subjected to in vitro nucleic acid amplification to produce data that is analyzed by using a Fourier Transform based algorithm are disclosed.... Agent: Gen Probe Incorporated

20060286571 - Methods of predicting methotrexate efficacy and toxicity: The present invention provides methods for analyzing genetic and/or metabolite biomarkers to individualize methotrexate (MTX) therapy. For example, the assay methods of the present invention are useful for predicting whether a patient will respond to MTX and/or has a risk of developing toxicity to MTX based upon the genotype of... Agent: Townsend And Townsend And Crew, LLP

20060286555 - Microarray support for bioprobe synthesis: A system for conducting chemical and/or biochemical reactions is provided, comprising a reaction substrate (A) with a multiplicity of reactor zones (C), said reaction substrate (A) having a substantially flat top surface and a substantially flat bottom surface, the reaction substrate (A) being porous with a multiplicity of essentially parallel... Agent: Amster, Rothstein & Ebenstein LLP

20060286582 - Microchip assembly: Provided is a microchip assembly including a base holder, a microchip installed on the base holder and having at least one input hole into which a reaction sample is input and at least one microchamber accommodating the input reaction sample, a flipper rotatably installed at the outside of the microchip... Agent: Cantor Colburn, LLP

20060286564 - Modified pol iii replicases and uses thereof: The invention provides Pol III α mutants, and modified Pol III replicases comprising the same, and methods of using modified Pol III replicases for a variety of nucleic acid replication reactions.... Agent: Todd A. Lorenz Dorsey & Whitney LLP

20060286583 - Multiplex branched-chain dna assays: Methods of detecting two or more nucleic acids in a multiplex branched-chain DNA assay are provided. Different nucleic acids are captured through cooperative hybridization events on different, identifiable subsets of particles or at different selected positions on a spatially addressable solid support. Compositions, kits, and systems related to the methods... Agent: Quine Intellectual Property Law Group, P.C.

20060286580 - Multiplexed polymerase chain reaction for genetic sequence analysis: A PCR method involving: providing a biological sample suspected of containing one or more pathogen nucleic acids; adding a plurality of PCR primers corresponding to genes found in the pathogens; and performing a polymerase chain reaction on the sample to amplify a subset of the nucleic acids that correspond to... Agent: Naval Research Laboratory Associate Counsel (patents)

20060286579 - Normalization genes: This invention provides gene sequence identities and methods for the determination of cellular gene expression and the comparison of expression levels between different gene sequences and between different cells. The gene sequences may be used as reference, normalization, or “housekeeping” gene sequences, the expression of which remains consistent in individual... Agent: Townsend And Townsend And Crew, LLP

20060286558 - Normalization of samples for amplification reactions: The present invention provides oligonucleotide primers, compositions, methods, and kits for determining the number of cells from which a cell lysate originated. The invention relies on detection and amplification of unique genomic sequences within the genome of an organism of interest to determine the amount of genomic nucleic acid in... Agent: LatimerIPLaw, LLP

20060286559 - Nucleic acids for detection of listeria: Isolated nucleic acids and methods for detecting nucleic acid of Listeria in a test sample are provided. The isolated nucleic acids may be incorporated into polymerase chain reactions to provide for the rapid detection of Listeria in samples.... Agent: Fitch Even Tabin And Flannery

20060286599 - Open channel solid phase extraction systems and methods: The invention provides, inter alia, methods of extracting an analyte from a solution comprising the steps of: passing a solution containing an analyte through an extraction channel having a solid phase extraction surface, whereby analyte adsorbs to the extraction surface of said extraction channel; purging bulk liquid from said extraction... Agent: Phynexus, Inc.

20060286565 - Prediction of likelihood of cancer recurrence: The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.... Agent: Heller Ehrman LLP

20060286561 - Propargylethoxyamino nucleotides: wherein R1 and R2 are —H lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is —H or —H; W2 is —H or a moiety which renders the nucleoside incapable of forming a phosphodiester bond at the 3′-position; and W3 is —PO4, —P2O7, —P3O10, phosphate... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20060286567 - Salicylamide-lanthanide complexes for use as luminescent markers: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands... Agent: Morgan, Lewis & Bockius LLP (sf)

20060286560 - Surface treatment: A method for producing a monolayer of molecules on a surface is described. The method includes loading a stamp with seed molecules, transferring seed molecules from the stamp to the surface, and amplifying the seed molecules via an amplifying reaction to produce the monolayer. This method permits generation of complete... Agent: Ibm Corporation, T.j. Watson Research Center

20060286593 - Transforming growth factor alpha hi: The present invention discloses transforming growth factor alpha HI polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders and... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20060286570 - Use of photopolymerization for amplification and detection of a molecular recognition event: The invention provides methods to detect molecular recognition events. The invention also provides methods to detect the presence of or identify a target species based on its interaction with one or more probe species. The methods of the invention are based on amplification of the signal due to each molecular... Agent: Greenlee Winner And Sullivan P C

20060286605 - Calcium biosensor polypeptides and methods of use: The invention features methods and compositions for determining states of intracellular calcium stores in a eukaryotic cell. Also provided are methods for identifying an agent (e.g., a gene product or small molecule compound) that modulates intracellular calcium store levels (e.g., by modulating store operated calcium (SOC) influx), as well as... Agent: Bozicevic, Field & Francis LLP

20060286606 - Clandestine laboratory (clan-lab) home test kit system, protocol, method and apparatus: This invention is comprised of a system, protocol, method and apparatus for the assessment of properties that may have been, or are being, subject to clandestine drug manufacturing and/or processing activities. The invention includes a comprehensive home test kit to be used in or upon a suspect premises to detect,... Agent: Troy Oliver

20060286603 - Combinatorial libraries of monomer domains: Methods for identifying discrete monomer domains and immuno-domains with a desired property are provided. Methods for generating multimers from two or more selected discrete monomer domains are also provided, along with methods for identifying multimers possessing a desired property. Presentation systems are also provided which present the discrete monomer and/or... Agent: Townsend And Townsend And Crew, LLP

20060286600 - High throughput one-hybrid system: The invention relates to a new high throughput yeast one-hybrid screening system.... Agent: Fish & Richardson PC

20060286607 - Isolation of proteins involved in posttranscriptional gene silencing and methods of use: The present invention includes a method for detecting and isolating sugarcane proteins that interact with the HC-Pro and P1 proteins of SrMV and other proteins involved in gene silencing, particularly in sugarcane. The method uses a two hybrid assay with an HC-Pro, P1, or other silencing-related protein-containing bait protein and... Agent: Baker Botts L.L.P.

20060286604 - Lectin binding to choroidal neovascularization: The present invention involves the identification of choroidal neovascularization (CNV) based on lectin binding patterns in choroidal and/or Bruch's membranes. The use of lectins to target therapeutic agents to CNV also is disclosed.... Agent: Fulbright & Jaworski L.L.P.

20060286602 - Method and markers for the diagnosis of renal diseases: Certain embodiments of the invention relate to means and methods for the diagnosis of a renal disease, particularly to differential diagnosis. Renal diseases of particular interest in the context of the invention are IgA-nephropathy, membranous glomerulonephritis (MGN), minimal-change-disease (MCD), focal segemental glomerulosclerosis (FSGS), and diabetic nephropathy. Particularly, the method comprises... Agent: Dardi & Associates, PLLC

20060286601 - Prolyl endopeptidase mediated destruction of t cell epitopes in whole gluten: Celiac Sprue and/or dermatitis herpetiformis are treated by interfering with HLA binding of immunogenic gluten peptides. The antigenicity of gluten oligopeptides and the ill effects caused by an immune response thereto are decreased by administration of an HLA-binding peptide inhibitor. Such inhibitors are analogs of immunogenic gluten peptides and (i)... Agent: Bozicevic, Field & Francis LLP

20060286608 - Method for screening transglutaminase 2 inhibitor or activator: Disclosed herein is a method for screening a TGase 2 inhibitor or activator, based on the finding that TGase 2-induced NF-κB activation is attributed to the polymerization of I-κBα, in which the level of free or polymerized I-κBα proteins or the level of NF-κB is measured to determine the TGase... Agent: Arent Fox PLLC

20060286609 - Rabbit monoclonal antibody against id1 protein: The present invention relates to a rabbit monoclonal antibody that binds to human Id1 protein and/or mouse Id1 protein with high specificity and high affinity. The antibody has a binding constant, measured with respect to human Id1 protein and/or mouse Id1 protein, equal to or greater than 1×108/molar. The antibody... Agent: Howrey LLP

20060286610 - Identification of ligands by selective amplification of cells transfected with receptors: The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions. The present invention also relates to a method of identifying compounds which act as inverse agonists of the 5-HT2A receptor, the method comprising contacting a constitutively... Agent: Knobbe Martens Olson & Bear LLP

20060286611 - Antibodies against biotinylated histones and related proteins and assays related thereto: Described are specific biotinylation sites in histones, polypeptide fragments of histones comprising such biotinylation sites, and antibodies that selectively bind to such biotinylated sites. Also described are methods to detect biotinylation in a sample, to detect biotinyl transferase activity in a sample, to identify regulators of biotinylation, and to detect... Agent: Sheridan Ross PC

20060286613 - Recombinant adenylate cyclase of bordetella sp. for diagnostic and immunomonitoring uses, method of diagnosing or immunomonitoring using said recombinant adenylate cyclase, and kit for diagnosing or immunomonitoring comprising said recombinant adenylate c: Diagnostic testing and immunomonitoring that uses genetically detoxified Bordetella pertussis CyaA as a delivery system are effective in tracking any immune responses, such as those generated by infectious and non-infectious diseases, or vaccinations, for example. T cells previously stimulated by a given antigen can be restimulated in vitro by the... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060286612 - Spore specific antibodies: The invention relates to spore specific antibodies. Compositions and methods relating to the antibodies are provided along with the hybridomas that produce the antibodies. The antibodies are specific for the spores of B. anthracis relative to the vegetative form of the cells. The antibodies are also specific for the spores... Agent: Townsend And Townsend And Crew, LLP

20060286616 - Menopause stage monitor: The present invention provides a portable menopausal phase monitor with which subjects can learn if they are menopausal, and if so, which phase they are at by using a body fluid such as urine, blood, or the like, as a test sample. A menopausal phase monitor of the present invention... Agent: Knobbe Martens Olson & Bear LLP

20060286614 - Method for monitoring coagulability and hypercoagulable states: The assay of soluble endothelial protein C receptor (sEPCR) is useful to monitor effective thrombin levels and a hypercoagulable state. An assay for sEPCR is therefore useful to monitor ongoing effectiveness of anticoagulant therapy. A sEPCR ELISA assay is particularly useful for this purpose. A state of hypercoagulability in patients... Agent: Fulbright & Jaworski L.L.P. A Registered Limited Liability Partnership

20060286615 - Novel non-invasive marker for liver function and disease: A monoclonal antibody or fragment thereof, capable of specifically binding to at least one epitope of sH2a and/or being elicited by at least one epitope, and assays, kits, and methods of use thereof diagnosing liver disease or condition, detecting liver function and assessing the efficacy of therapy to a liver... Agent: Martin Moynthan Prtsi, Inc.

20060286617 - Ptx3 as an early prognostic indicator of cardiovascular and cerebrovascular pathologies: A method for the early determination of the risk of death or heart failure in infarction patients, and the risk of death, relapse or complications in ictus patients, the method being based on the determination of PTX3 from plasma or blood.... Agent: Young & Thompson

20060286618 - Amp assay: The invention provides a method for detecting AMP, which method comprises treating a sample with adenylate kinase, nucleoside-diphosphate kinase, and a phosphate donor under conditions such that when AMP is present in the sample ATP is formed; and detecting the ATP so formed, preferably with the light-producing luciferase-luciferin reaction.... Agent: Kristian Jansson Aumakatu 3

20060286619 - Device for performing analyses on biological fluids and related method: A device for measuring the sedimentation rate in biological fluids, and particularly the erythrocyte sedimentation rate in blood samples. The device comprises: holders (3) for test tubes (P) containing samples of biological fluid; agitator devices (25) for agitating the test tubes; at least one detector (17, 19) for reading the... Agent: Mcglew & Tuttle, PC

20060286620 - Glucose analysis instrument: Glucose analysis instrument for diabetics, comprising a measuring device for determining glucose concentration values, a displaying device for displaying glucose concentration values, a signaling device for generating a reminder signal, and a control and evaluation device that comprises a processor and a data memory and is used to determine reminder... Agent: Roche Diagnostics Corporations Inc.

20060286621 - Extraction methods and assays for feed enzymes: This invention relates to methods of the detection of enzymatically active enzymes in feed added in the pre-pelleting stage. Further, this invention relates to the field of detecting thermotolerant enzymes added to feed in the pre-pelleting stage. In particular, the invention relates to the detection of a phytase enzyme, in... Agent: Syngenta Biotechnology, Inc. Patent Department

20060286622 - Polypeptides exhibiting pde7 activity and their use for selecting compounds which inhibit pde 7 enzyme activity: The present invention relates to polypeptides exhibiting a higher PDE7 phosphodiesterase activity than the endogenous full length PDE7 and their use for selecting compounds which inhibit PDE7 enzyme activity.... Agent: Warner-lambert Company

20060286623 - Three dimensional object manipulating method and device: This invention is used for the three dimensional microanalysis and observation of small object especially under microscope. This invention is applied on to the biomedical field as cell or tissue observation and manipulation. Three dimensional observation and manipulation method and device are cited in claim 1 and 2. And further... Agent: Olympus America Inc/seg

20060286624 - Method for identifying selective growth inhibitors: Selective growth inhibitors are identified by (i) providing a semi-solid nutrient medium (e.g., an agar plate) co-seeded with a strain of cells (e.g., bacteria or fungi) that is sensitive to growth inhibitors having a particular mode of action and with a strain that is essentially the same as the sensitive... Agent: Merck And Co., Inc

20060286625 - Rapid enrichment for listeria: A non-selective and selective media and method are provided for the rapid enrichment of Listeria from samples. The method includes inoculating a sample that may contain Listeria into a non-selective or selective medium. Also, a sample that may contain Listeria may be provided by an environmental sponge or swab. More... Agent: Fitch Even Tabin & Flannery

20060286627 - Methods and kits for obtaining a metabolic profile of living animal cells: The present invention relates to growing and testing eukaryotic cells (e.g., animal or plant cells) in a multi-test format. In particular, the present invention provides methods and kits for obtaining a complex metabolic profile of animal cells. In addition, the present invention provides tools for assaying the effects of candidate... Agent: Medlen & Carroll, LLP

20060286626 - Selective chromophores: e

20060286628 - Heat recovery from a biomass heat source: A method and system for recovering heat from a pretreated hot biomass stream is described. The method and system for heat recovery includes a flash cooler connected to a direct contact condenser. A liquid portion of the hot biomass stream flashes into vapors upon the hot biomass stream entering the... Agent: Brinks Hofer Gilson & Lione

20060286629 - Processing of peptides and proteins: The invention provides novel methionine aminopeptidase enzymes, their use, and related compounds and methods.... Agent: Novo Nordisk, Inc. Patent Department

20060286635 - Albumin fusion proteins: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060286638 - Cell lines: The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins.... Agent: Avigenics, Inc.

20060286639 - Complementary dnas encoding proteins with signal peptides: The sequences of cDNAs encoding secreted proteins are disclosed. The cDNAs can be used to express secreted proteins or fragments thereof or to obtain antibodies capable of specifically binding to the secreted proteins. The cDNAs may also be used in diagnostic, forensic, gene therapy, and chromosome mapping procedures. The cDNAs... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20060286632 - Cysteine-containing peptides having antioxidant properties: Cysteine containing amphipathic alpha helices of the exchangeable apolipoproteins, as exemplified by apolipoprotein (apo) A-IMilano (R173C) and apoA-IParis, (R151C) were found to exhibit potent antioxidant activity on phospholipid surfaces. The addition of a free thiol, at the hydrophobic/hydrophilic interface of an amphipathic alpha helix of synthetic peptides that mimic HDL-related... Agent: Townsend And Townsend And Crew, LLP

20060286631 - Method for preparating t-20 peptide by high cell density cultivation of recombinant e. coli containing t-20 peptide coding gene: The present invention relates to a method for preparing a T-20 peptide by the high-cell-density cultivation of recombinant E. coli containing a T-20 peptide-coding gene, as well as a method for isolating and purifying the T-20 peptide with high purity from E. coli where the T-20 peptide have been expressed.... Agent: J.c. Patents

20060286633 - Methods for production of proteins: The current invention provides methods for producing a polypeptide as inclusion bodies in bacterial host cells. The present methods are carried out by forming a gene construct comprising the genetic sequence encoding a polypeptide operatively linked to that of an inclusion partner protein, such as E. coli thioredoxin or a... Agent: Sterne, Kessler, Goldstein & Fox PLLC

20060286630 - Posh interacting proteins and related methods: The application provides novel complexes of POSH polypeptides and POSH-associated proteins. The application also provides methods and compositions for treating POSH-associated diseases such as viral disorders, cancer, and neurological disorders.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20060286640 - Process for production of polypeptides: Vectors for producing polypeptides heterologous to prokaryotes are described comprising, along with the polypeptide-encoding nucleic acid, anti-termination nucleic acid that inhibits intragenic transcription termination with a non-lambda promoter therefor and/or nucleic acid encoding a GreA or GreB protein and a promoter therefor. Also described are processes for producing a heterologous... Agent: Genentech, Inc.

20060286637 - Production of sialylated n-glycans in lower eukaryotes: The present invention relates to eukaryotic host cells which have been modified to produce sialylated glycoproteins by the heterologous expression of a set of glycosyltransferases, including sialyltransferase and/or trans-sialidase, to become host-strains for the production of mammalian, e.g., human therapeutic glycoproteins. Novel eukaryotic host cells expressing a CMP-sialic acid biosynthetic... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20060286634 - Vector: A vector comprising a nucleotide sequence of interest (“NOI”) encoding a product of interest (“POI”) is described. The NOI and/or the POI is capable of recognizing a tumor, such that in use the vector is capable of delivering the NOI and/or the POI to the tumor.... Agent: Townsend And Townsend And Crew, LLP

20060286636 - Vegf variants: Applicants have defined the pro-inflammatory domain of the Vascular Endothelial Growth Factor VEGF164(165) protein molecule using VEGF164 protein mutants in which the heparin binding domain is inactivated through alanine scanning, site directed mutagenesis. The invention provides novel VEGF variants having a modified heparin binding domain. The VEGF variants modified heparin... Agent: (osi) Eyetech, Inc.

20060286641 - Interferon-alpha/beta binding fusion proteins and therapeutic uses thereof: Polypeptides and multimeric polypeptides capable of binding interferon α and/or interferon β which are useful therapeutically in methods of treating interferon α/β-related conditions or diseases.... Agent: Regeneron Pharmaceuticals, Inc

20060286642 - Postweaning multisystemic wasting syndrome and porcine circovirus from pigs: The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in... Agent: Frommer Lawrence & Haug

20060286643 - Method for producing l-amino acid using bacterium of enterobacteriaceae family having expression of yafa gene attenuated: The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the yafA gene.... Agent: Cermak & Kenealy LLP Acs LLC

20060286644 - Process for preparing l-amino acids using improved strains of the enterobacteriaceae family: The invention relates to a process for preparing L-amino acids by fermenting recombinant microorganisms of the Enterobacteriaceae family, characterized in that a) the desired L-amino acid-producing microorganisms, in which the ytfQ-ORF, or nucleotide sequences or alleles encoding the gene product, is/are enhanced, in particular overexpressed, is cultured in a medium... Agent: Fitch, Even, Tabin & Flannery

20060286645 - Polynucleotide constructs for increased lysine production: The invention relates to production of lysine, and provides several isolated polynucleotide molecules useful for the production of L-lysine. One such polynucleotide encodes an aspartate kinase (ask), an aspartate-semialdehyde dehydrogenase (asd) and a dihydrodipicolinate reductase (dapB). Other polypeptides encode ask, asd, dapB and a diaminopimelate dehydrogenase (ddh); ask, asd, dapB,... Agent: Buchanan Ingersoll PC (archer Daniels Midland Company)

20060286646 - Stereoselective reduction process for the preparation of pyrrolotriazine compounds: The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula Ib:... Agent: Louis J. Wille Bristol-myers Squibb Company

20060286648 - Enhanced production of lipids containing polyenoic fatty acid by very high density cultures of eukaryotic microbes in fermentors: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.... Agent: Sheridan Ross PC

20060286649 - Enhanced production of lipids containing polyenoic fatty acid by very hugh density cultures of eukaryotic microbes in fermentors: The present invention provides a process for growing eukaryotic microorganisms which are capable of producing lipids, in particular lipids containing polyenoic fatty acids. The present invention also provides a process for producing eukaryotic microbial lipids.... Agent: Sheridan Ross PC

20060286647 - Esters of conjugated unsaturated acids (conjugated acid esters), corresponding methods and use: Esters (A) of conjugatedly unsaturated carboxylic acids process for preparing them, and compositions containing said esters, curable with actinic radiation, curable thermally and with actinic radiation or curable oxidatively.... Agent: Basf Corporation

20060286651 - Increasing perhydrolase activity in esterases and/or lipases: The invention provides for methods of modifying n esterase or a lipase enzyme to introduce perhydrolase activity or to increase the already-existing perhydrolase activity. The invention also provides for methods of converting an polypeptide having predominantly esterase and/or lipase catalytic activity to a polypeptide having predominantly perhydrolase activity.... Agent: Fish & Richardson P.C.

20060286650 - Vector capable for transformation of labyrinthulomycota: An object of the present invention is to provide a transformation system for Labyrinthulomycota that allows the elucidation of biosynthetic mechanisms of lipids such as PUFA and carotenoids as well as for the construction of a high production system and the design and development of novel functional lipid molecules by... Agent: Birch Stewart Kolasch & Birch

20060286652 - Gene improving temperature-tolerance of acetic acid bacterium, acetic acid bacterium bred using the gene and process for producing vinegar using the acetic acid bacterium: The present invention is intended to provide a novel gene originating in an acetic acid bacterium, which participates in temperature tolerance; a method of improving the temperature tolerance of a microorganism, in particular, an acetic acid bacterium using the above gene; and a method of efficiently producing vinegar having a... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20060286653 - Method for the production of glycerol by recombinant organisms: Recombinant organisms are provided comprising genes encoding a glycerol-3-phosphate dehydrogenase and/or a glycerol-3-phosphatase activity useful for the production of glycerol from a variety of carbon substrates. The organisms further contain disruptions in the endogenous genes encoding proteins having glycerol kinase and glycerol dehydrogenase activities.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20060286654 - Alcohol production using sonication: A system comprising one or more transducers and an alcohol production facility having a liquid medium processing stream, the alcohol production facility adapted for use with the one or more transducers is provided. In one embodiment, the one or more transducers apply sonication to the liquid medium processing stream in... Agent: Schwegman, Lundberg, Woessner & Kluth, P.A.

20060286655 - Modified kap polypeptides and use thereof: Modified polypeptides of the KAP (keratin-associated protein) family and their use in compositions for caring for, treating, strengthening and/or repairing keratin substrates, in particular keratin fibres.... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20060286656 - Characterization of the i-spomi endonuclease from fission yeast: Isolated DNAs encoding the enzyme I-SpomI and its recognition and cutting site are provided. The DNA sequences can be incorporated in cloning and expression vectors, transformed cell lines and transgenic animals. The vectors are useful in gene mapping and site-directed insertion of genes.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060286657 - Novel bioconjugation reactions for acylating polyethylene glycol reagents: A method for conjugation of PEG to a protein in an aqueous solution at a pH less than or equal to about 7.0 or neutral pH comprising combining an activated PEG reagent and a protein in the presence of an activating agent at a pH of less than about 7.0... Agent: Perkins Coie LLP

20060286658 - Method for concentrated growth of a paraffinophilic microorganism for bioremediation and an associated apparatus: A method of growth of selected microorganism cultures by selectively baiting paraffinophilic microorganisms for concentrated growth is provided. The method includes providing a receptacle containing an aqueous solution and adjusting the solution to mimic the environmental conditions conducive to enhancing growth of the target microorganisms. The method then further includes... Agent: Eckert Seamans Cherin & Mellott

20060286659 - Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.... Agent: Kilyk & Bowersox, P.l.l.c.

20060286660 - Biosensors having reduced haemocrit effect: A sensor which has at least first and second electrodes and a volume therebetween for receiving a liquid sample, includes an agent that lyses cells, wherein the lysing agent is in or on the surface of the first electrode.... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20060286661 - Cell-based platform for high throughput screening: The present invention relates to an apparatus for testing multiple sample compounds for their biological effect comprising a porous block having substantially planar top and bottom surfaces. The top surface comprises a plurality of cell adhesive regions and cell dis-adhesive regions and the bottom surface provides multiple sites to load... Agent: Honeywell International Inc.

20060286662 - Medical diagnostic test strip: A medical diagnostic test strip is disclosed, which comprises: a top plate, having at least a cell arranged therein for storing an enzyme, each cell having at least a microchannel channeling out to the outer rim of the top plate therefrom while enabling one of the plural microchannel to guide... Agent: Bruce H. Troxell

20060286663 - Method for producing a colorimetric resonant reflection biosensor on rigid surfaces: The invention provides methods for fabricating calorimetric resonant reflection biosensors.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20060286664 - Bioreactor for the manufacture of tissue engineered blood vessels: The invention relates to bioreactors having an enclosed chamber, a sheet growth module, a rollable mandrel, and a clamp for holding the sheet to the mandrel for rolling for the manufacture of a tissue engineered blood vessel (TEBV). The TEBV is made from a cultured fibroblast sheet rolled into a... Agent: Fish & Richardson P.C.

20060286665 - System for sustained microbial production of hydrogen gas in a bioreactor utilizing an equalization tank: The present invention provides a system of hydrogen production from microorganisms, wherein a bioreactor provides an environment conducive to the production of hydrogen from hydrogen producing microorganisms and restrictive to the production of methane from methanogens. The hydrogen production system further includes an equalization tank that provides improved control of... Agent: Eckert Seamans Cherin & Mellott

20060286668 - Animal-cell culture media comprising non-animal or plant-derived nutrients: The present invention provides serum-free cell culture media formulations which are capable of supporting the in vitro cultivation or animal cells. The media comprise at least one nutrient of non-animal derivation, such as at least one plant peptide and/or at least one non-animal or plant lipid and/or fatty acid. The... Agent: Sterne, Kessler, Goldstein & Fox PLLC

20060286669 - Isolation of multi-lineage stem cells: The present application discloses a method of manipulating a biological sample of cells, which includes multi-lineage stem cells, progenitor cells, other marrow stromal cells: allowing the sample of cells to settle in a container; transferring supernatant from the container to another container; and isolating cells from the supernatant, which has... Agent: Jhk Law

20060286666 - Methods and apparatuses for culturing stem cell using biomaterial shell: Disclosed are methods and apparatuses for culturing stem cell using biomaterial shell, e.g. fertilized zebrafish chorions, which may induce formation of embryonic bodies, cell proliferation, and cell differentiation to other types effectively inside the chorions without adding any inducing agents or cell differentiation stimulants. There is provided an apparatus for... Agent: Armstrong, Kratz, Quintos, Hanson & Brooks, LLP Intellectual Property Law Offices

20060286667 - Methods for detection and production of influenza viruses: The present invention generally relates to the field of diagnostic microbiology, and, more particularly; to compositions and methods for detecting and differentiating one or more viruses or other intracellular parasites present in a specimen. The present invention also provides compositions and methods to evaluate the susceptibility of organisms to antimicrobial... Agent: Medlen & Carroll, LLP

20060286670 - Transplant acceptance inducing cells of monocytic origin and their preparation and use: The invention relates to transplant acceptance inducing cells of monocytic origin, their production as well as their use for generating transplant acceptance. The invention also relates to the monoclonal antibody GM-7, which specifically recognises human transplant acceptance inducing cells of the invention. The invention further relates to the use of... Agent: Arnold & Porter LLP Attn:IPDocketing Dept.

20060286671 - Efficient generation of expression cell lines through the use of scorable homeostatic reporter genes: The present invention provides methods for site-specific recombination in a cell, as well as vectors which can be employed in such methods. The methods and vectors of the present invention can be used to obtain persistent gene expression in a cell and to modulate gene expression. One preferred method according... Agent: Pdl Biopharma, Inc.

20060281066 - Novel and practical serological assay for the clinical diagnosis of leishmaniasis: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite... Agent: Office Of The Staff Judge Advocate U.s. Army Medical Research And Material Command

20060281068 - Cytological methods for detecting a disease condition such as malignancy by raman spectroscopic imaging: Raman molecular imaging (RMI) is used to detect mammalian cells of a particular phenotype. For example the disclosure includes the use of RMI to differentiate between normal and diseased cells or tissues, e.g., cancer cells as well as in determining the grade of said cancer cells. In a preferred embodiment... Agent: Daniel H. Golub

20060281069 - Ion channel assay methods: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a... Agent: Knobbe Martens Olson & Bear LLP

20060281070 - Method of amidated peptide biosynthesis and delivery in vivo: endomorphin-2 for pain therapy: The invention provides an expression cassette comprising a DNA sequence encoding amino acids 1-99 of human preproenkephalin, a DNA sequence encoding a precursor of a carboxy-amidated peptide flanked by dibasic cleavage sites and optionally a DNA sequence encoding a marker protein (such as Enhanced Green Fluorescent Protein (GFP)) all in... Agent: Leydig Voit & Mayer, Ltd

20060281067 - Microluminometer chip and method to measure bioluminescence: An integrated microluminometer includes an integrated circuit chip having at least one n-well/p-substrate junction photodetector for converting light received into a photocurrent, and a detector on the chip for processing the photocurrent. A distributed electrode configuration including a plurality of spaced apart electrodes disposed on an active region of the... Agent: Akerman Senterfitt

20060281071 - Stearoyl-coa desaturase assay: A yeast-based method for identifying an agent that can modulate the activity of a human or mouse stearoyl-CoA desaturase (SCD) is disclosed. Further disclosed are substrate specificities of various human and mouse SCDs, which facilitate the identification of modulators for human and mouse SCDs.... Agent: Quarles & Brady LLP

20060281074 - Affinity-based detection of biological targets: A method of biochemical identification by: providing a plurality of capture species bound to one or more substrates and suspected of having one or more biological targets affinity bound to at least one capture species; detecting which capture species contain bound biological targets to generate a binding pattern; and identifying... Agent: Naval Research Laboratory Associate Counsel (patents)

20060281072 - Agonistic binding molecules to the human ox40 receptor: The present invention provides binding molecules, such as human binding molecules, that bind to and stimulate the human OX40-receptor. The invention also provides nucleic acids encoding such binding molecules. Methods for producing such binding molecules are also provided by the present invention. The binding molecules and nucleic acids are useful... Agent: Trask Britt

20060281073 - Broadening adenovirus tropism: Recombinant adenoviruses comprising modified fiber proteins which expand the tropism of the adenovirus in comparison to wild-type virus are disclosed. The modified fiber proteins described herein contain a peptide ligand for a cell surface binding site other than CAR comprising a 14 amino acid core sequence containing both fixed and... Agent: Merck And Co., Inc

20060281077 - Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor: Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20060281075 - Purification of viruses, proteins and nucleic acids: Viruses, virus-like particles and protein and nucleic acid components are extracted from biological material using high ionic strength, activated carbon and changes in pH. The purified compositions are stored in similar or different conditions preferably with a higher pH.... Agent: Large Scale Biology Corporation

20060281076 - Substrate functionalization method for high sensitivity applications: A method for functionalizing substrates such as magnetic beads and glass slides is provided. The method involves providing substrate surfaces with activated polyacrylic acid (PAA) and attaching one or more desired capture probes. Substrates prepared by the method are particularly useful in ultrasensitive detection assays as they exhibit very low... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20060281095 - 44 human secreted proteins: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing... Agent: Human Genome Sciences Inc. Intellectual Property Dept.

20060281113 - Accessible polynucleotide libraries and methods of use thereof: Disclosed are methods of assembling nucleic acid constructs from component parts in a manner that is not dependent on the sequence of the component parts. The methods may be used to assemble large nucleic acid constructs from multiple component parts in one or more reactions. The methods may also be... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20060281107 - Acute myelogenous leukemia biomarkers: The present invention provides novel compositions and their use in classifying acute myelogenous leukemia.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20060281117 - Alternatively spliced isoform of calcium channel, voltage dependent, alpha-1g subunit (cacna1g): The present invention features nucleic acids and polypeptides encoding novel splice variant isoforms of calcium channel, voltage dependent, alpha-1G subunit (CACNA1G). The polynucleotide sequence of CACNA1Gsv1 is provided by SEQ ID NO 4. The amino acid sequence of CACNA1Gsv1 is provided by SEQ ID NO 5. The polynucleotide sequence of... Agent: R. Douglas Bradley Merck & Co., Inc.

20060281094 - Apparatus for processing a fluid sample: This invention relates to an apparatus for processing a fluid sample comprising: (i) a platform comprising: (a) a chamber suitable for receiving a sample; and (b) a functional component; (ii) an arm capable of being raised and lowered and including a means for removeably attaching to the functional component such... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20060281101 - Biobriefcase: A bio-briefcase system for analyzing a sample for the presence of biological agents. The bio-briefcase system comprises a housing, an immunoassay section operatively connected to the housing, and/or a nucleic acid assay section operatively connected to the housing.... Agent: Eddie E. Scott Assistant Laboratory Counsel

20060281090 - Capsid-modified adenovirus vectors and methods of using the same: Adenovirus fiber mutated in the regions involved in the recognition and the binding of blood factor proteins, and adenoviruses comprising such fibers are provided.... Agent: Townsend And Townsend And Crew, LLP

20060281108 - Compositions and methods for the analysis of degraded nucleic acids: The invention relates to compositions and methods for gene expression analysis. In some embodiments, the invention provides compositions and methods for amplifying targets in a degraded nucleic acid sample. In some embodiments, the invention provides methods for determining the quality of nucleic acids (e.g., the degree of degradation) in a... Agent: Quine Intellectual Property Law Group, P.C.

20060281128 - Compositions and methods using lentivirus-based vectors for generating immune responses: The present invention relates to multiple novel approaches for the generation of an immune response in an animal, such as a human, using lentivirus-based vector technology. The invention provides for the ability to mimic the efficacy of a live attenuated (LA) vaccine, without exposing the patient to the risk of... Agent: Virxsys C/o Mofo Sd

20060281121 - Computing with biomolecules: The present invention is of a molecular entity comprising a polypeptide core and nucleic acid sequences attached thereto which is capable of forming a universal logic gate such as the NAND gate. Specifically, the present invention can be used to device a molecular computing unit which can be used to... Agent: Prtsi, Inc.

20060281119 - Controlled alignment of nano-barcodes encoding specific information for scanning probe microscopy (spm): The methods, apparatus and compositions disclosed herein concern the detection, identification and/or sequencing of biomolecules, such as nucleic acids or proteins. In certain embodiments of the invention, coded probes comprising a probe molecule attached to one or more nano-barcodes may be allowed to bind to one or more target molecules.... Agent: Raj S. Dave Morrison & Foerster LLP

20060281112 - Design of capture molecules for the detection of amplicons with high sensitivity: The invention relates to a method for the design and/or the preparation of a polynucleotide capture molecule for detecting an amplicon having one strand serving as target to be detected and/or quantified after hybridization on said capture molecule, comprising the steps of: (a) selecting a primer pair defining the amplicon;... Agent: Howrey LLP

20060281124 - Device and method for purification of biological materials: An apparatus, method and kit for isolating a biomolecule from a sample. The sample comprises a complex biological material, which includes insoluble matter. Some embodiments of the apparatus and kit include a reservoir and means for capturing the biomolecule either contained within or coupled to the reservoir. The reservoir can... Agent: Michael Best & Friedrich, LLP

20060281085 - Diagnostics and therapeutics for diseases associated with phosphodiesterase 1b (pde1b): The invention provides a human PDE1B which is associated with the cardiovascular disorders, metabolic diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, metabolic... Agent: Banner & Witcoff

20060281093 - Erbb receptor methods and kits for monitoring chemotherapy resistance: The present invention relates to monitoring of ErbB receptor levels in methods and kits for determining the prognosis of cancer in a subject or improving the effectiveness of a cancer treatment. The invention also provides a method for predicting the recurrence of clinical signs of a cancer in a subject.... Agent: Jones Day

20060281091 - Genes regulated in ovarian cancer a s prognostic and therapeutic targets: This invention relates to the use of genomic analysis to detect the presence of ovarian cancer in a patient from a sample of tissue or blood and to kits for carrying out this determination. In addition this invention relates to methods to treat a patient with ovarian cancer.... Agent: Novartis Corporate Intellectual Property

20060281082 - Genome partitioning: This invention relates to ‘genome partitioning’ and nucleic library construction, for example for sequence variation discovery and screening. The method employs a plurality of restriction enzymes in order to reliably reproduce a representative partition of the entirety of a sample nucleic acid based on the restriction ends of one or... Agent: Dann, Dorfman, Herrell & Skillman

20060281105 - High throughput multiplex dna sequence amplifications: The present invention provides methods of designing PCR primers that allow the efficient and simultaneous amplification of a large number of different desired DNA fragments in a single multiplex PCR and minimize the formation of nonspecific extensions of undesired DNA fragments. The present invention allows a multiplex PCR to use... Agent: Perkins Coie LLP

20060281078 - Human fast-1 gene: hFAST-1 is a human forkhead activin signal transducer gene. The hFAST-1 protein has the ability to bind to human Smad2 and activate an activin response element (ARE). The hFAST-1-dependent activation of ARE is dependent on endogenous Smad4 and stimulation of the TGF-β receptor. The hFAST-1 protein binds to a novel... Agent: Banner & Witcoff

20060281125 - Icbp90 polypeptide and its fragments and polynucleotides coding for said polypeptides and applications for diagnosing and treating cancer: The invention concerns a novel ICBP90 (Inverted CCAAT box binding protein 90) and its fragments, polynucleotides coding for said polypeptides and specific antibodies directed against said polypeptides. The invention also concerns methods and kits for diagnosing cell proliferation and compounds useful as medicine for preventing and/or treating pathology involving cell... Agent: Foley And Lardner LLP Suite 500

20060281083 - Identification of genes involved in angiogenesis, and development of an angiogenesis diagnostic chip to identify patients with impaired angiogenesis: The invention is directed to methods for angiotyping individual patients to predict the likelihood of whether a given individual will develop good vs. poor collaterals naturally. Accordingly, this can involve obtaining and providing a list of genes involved in collateral development. In particular, angiotyping individual patients can be used to... Agent: Wolf Greenfield & Sacks, PC

20060281116 - In situ heat induced antigen recovery and staining apparatus and method: Contemplated herein is an automated microscope slide antigen recovery and staining apparatus and method that features a plurality of individually operable miniaturized pressurizable reaction compartments for individually and independently processing a plurality of individual microscope slides. The apparatus preferably features independently movable slide support elements each having an individually heatable... Agent: Dunlap, Codding & Rogers P.C.

20060281103 - Increased sensitivity of nucleic acid-based detection of organisms by fractionation of target genomes: A method of analyzing a sample for detection of presence or absence of an organism of interest in the sample comprising (a) obtaining a sample; (b) subjecting the sample to a disruption treatment sufficient to fractionate any nucleic acid sequences present in the sample; and (c) detecting for presence or... Agent: Patent Group Attn: J. Kenneth Joung

20060281111 - Kinase peptides and antibodies: The invention relates to novel kinase peptides and antibodies, as well as nucleic acids related to them. The peptides, antibodies and the nucleic acids are useful for the detection, staging and monitoring of the progression of a kinase-mediated disease, as well as for determining or monitoring the efficacy of treatment.... Agent: Sonnenschein Nath & Rosenthal LLP For Paula Evans

20060281104 - Leuco dye particles and uses thereof: The invention provides methods and compositions for detecting the presence of, or for measuring amounts of, molecular targets, particularly molecular complexes comprising two or more proteins, such as receptor complexes of cell surface membranes. In one aspect of the invention, reagent pairs are provided that comprise a reactive species generator... Agent: Stephen C. Macevicz

20060281088 - Markers for lxr activation: The present invention relates to surrogate markers for LXR activation, and methods of diagnosing a disease linked to LXR activation, methods of monitoring the treatment of patients suffering from a disease linked to LXR activation, and methods of identifying compounds which modulate LXR activity.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20060281115 - Max quadruplex nucleic acids and uses thereof: The MAX regulatory region contains a functional quadruplex structure. Thus, provided herein are MAX quadruplex nucleic acid acids, nucleic acid therapeutics that target quadruplex-altered nucleotide sequences and methods, methods for identifying compounds that modulate the biological activity of a native MAX quadruplex DNA, and methods for modulating the biological activity... Agent: Morrison & Foerster LLP

20060281098 - Method and kits for multiplex hybridization assays: The invention provides a method for genotyping interfering polymorphic loci in a target polynucleotide, such as a strand of genomic DNA, in a multiplex hybridization-based assay. The invention also provides nucleic acid standards for validating the performance of such hybridization-based assays. In one aspect, the method of the invention is... Agent: Chief Intellectual Property Counsel Affymetrix, Inc.

20060281129 - Method for detecting biopolymers: A technique is provided that easily detects biopolymers such as a DNA or a protein by utilizing semiconductor nanoparticles having different excitation wavelengths and fluorescence due to differences in particle size. By binding the semiconductor nanoparticles with avidin (or biotin), detection of biopolymers labeled with biotin (or avidin) is enabled.... Agent: Reed Smith Hazel & Thomas LLP

20060281092 - Method for the reverse transcription and/or amplification of nucleic acids: The present invention relates to a process for the reverse transcription and/or amplification of a product from a reverse transcription of a pool of nucleic acids of a specific type, this pool of nucleic acids originating from a complex biological sample or an enzymatic reaction.... Agent: Leon R Yankwich Yankwich & Associates

20060281084 - Method of detecting bifidobacterium infantis: PCR primers for detecting Bifidobacterium infantis comprising: a pair of a first oligonucleotide having a sequence of 20 or more continuous nucleotides selected from a nucleotide sequence of SEQ ID NO: 1 and a second oligonucleotide having a nucleotide sequence of SEQ ID NO: 2 or a nucleotide sequence of... Agent: Knobbe Martens Olson & Bear LLP

20060281081 - Method of diagnosing colon and gastric cancers: Objective methods for detecting and diagnosing Colorectal and gastric carcinomas are described herein. In one embodiment, the diagnostic method involves the determining a expression level of colon or gastric cancer—associated gene that discriminate between colon or gastric cancer and nomal cell. The present invention further provides methods of screening for... Agent: Townsend And Townsend And Crew, LLP

20060281079 - Method of performing reverse transcription reaction using reverse transcriptase encoded by non-ltr retrotransposable element: The present invention relates to a method of preparing a cDNA molecule which includes: contacting an RNA molecule, in the presence of dNTPs, with a non-LTR retrotransposon protein or polypeptide having reverse transcriptase activity under conditions effective for production of a cDNA molecule complementary to the RNA molecule, said contacting... Agent: Edwin V Merkel Nixon Peabody

20060281097 - Method of processing and/or genome mapping of ditag sequences: Method of processing and/or genome mapping of ditag sequences There is provided a method and system for processing and/or mapping ditag nucleotide sequence(s) to a genome, the ditag sequence comprising the 5′ terminal tag and the 3′ terminal tag of a nucleic acid molecule or fragment thereof or genomic fragment.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20060281114 - Methods and compositions for assessment of pulmonary function and disorders: The present invention provides methods for the assessment of risk of developing occupational chronic obstructive pulmonary disease (OCOPD) in smokers and non-smokers using analysis of genetic polymorphisms. The present invention also relates to the use of genetic polymorphisms in assessing a subject's risk of developing OCOPD. Nucleotide probes and primers,... Agent: Knobbe Martens Olson & Bear LLP

20060281118 - Methods and compositions for rapid purification of proteasomes and methods of use of components thereof: Disclosed are methods for rapidly and efficiently purifying proteasomes using fusion proteins having homology to ubiquitin. Also disclosed are methods for assessing aberrant cell growth utilizing fusion proteins have homology to ubiquitin and a signal producing moiety.... Agent: Licata & Tyrrell P.C.

20060281096 - Methods and kits for detecting genetically modified organism (gmo): This invention provides a method for detecting genetically modified organism (GMO) comprising amplifying transgenes of GMO by biotin-labeled primer sets, hybridizing the amplified products with colored bead-labeled probes, and detecting the hybrids. This invention also provides a polynucleotide for detecting a transgene of genetically modified soybean. This invention further provides... Agent: Dougherty & Troxell One Skyline Place

20060281089 - Methods for detecting cancer and monitoring cancer progression: Mutant BNIP3 plays a functionally important role in the development of solid tumors and in resistance to chemotherapy and radiation treatments. The invention relates to methods of detecting cancer, methods of monitoring the progression of cancer, methods of identifying patients with cancer that is resistant to chemotherapy or radiation treatments,... Agent: Bereskin And Parr

20060281102 - Methods for detecting genetic haplotypes by interaction with probes: The present invention provides methods for determining genetic haplotype comprising identifying target nucleic acids or gene fragments, said nucleic acids or gene fragments comprising a haplotype of interest, and detecting at least one parameter displayed by one of a primer-dependent transcript, a probe, or a primer-dependent transcript/probe complex. Further provided... Agent: Wilson Sonsini Goodrich & Rosati

20060281126 - Methods for monitoring the expression of alternatively spliced genes: Methods, probe arrays and computer software products are provided for determining the arrangement of sequence elements. In one embodiment, methods for making and using exon chips are provided. The exon chips may be used to identify and quantify splice variants.... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20060281122 - Methods for the identification, assessment, and treatment of patients with cancer therapy: The present invention is directed to the identification of predictive markers that can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen prior to treatment. In particular, the present invention is directed to the use of certain individual and/or combinations of predictive... Agent: Millennium Pharmaceuticals, Inc.

20060281110 - Methods to identify antimicrobial compounds that interrupt ribosome biogenesis: The present invention discloses that essential and highly conserved GTPases (i.e., for example, YlqF, YqeH, YsxC, or YphC proteins) from Bacillus subtilis participate in ribosome biogenesis. Before this invention, the biological function of the GTPase proteins were unknown. These GTPase proteins are disclosed to affect translation and believed to promote... Agent: Medlen & Carroll, LLP Suite 350

20060281080 - Novel lipases and uses thereof: The invention relates to a newly identified polynucleotide sequence comprising a gene that encodes a novel lipolytic enzyme from Aspergillus niger. The invention features the full length nucleotide sequence of the novel gene, the cDNA sequence comprising the full length coding sequence of the novel lipolytic enzyme as well as... Agent: Morrison & Foerster LLP

20060281109 - Polymerases: Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate DNA templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-DNA complexes in each reaction cycle. The... Agent: Klauber & Jackson

20060281123 - Polynucleotide comprising single-nucleotide polymorphism associated with colorectal cancer, microarray and diagnostic kit comprising the same, and method of diagnosing colorectal cancer using the same: Provided are a polynucleotide for diagnosis or treatment of colorectal cancer including at least 10 contiguous nucleotides of a nucleotide sequence selected from the group consisting of nucleotide sequences of SEQ ID NOS: 1 and 2 and including a nucleotide at position 101 of the nucleotide sequence, or the complement... Agent: Cantor Colburn, LLP

20060281127 - Promoter sequences for urocortin ii and the use thereof: Various human urocortin II promoter sequences are disclosed. Nucleic acids and host cells that contain the promoter sequences are also disclosed. Further disclosed are various methods involving the use of these sequences. Also disclosed are methods of modulating the activity of a human urocortin II promoter sequence and methods of... Agent: Quarles & Brady LLP

20060281099 - Q-melt for polymorphism detection: The invention provides a new method of determining the presence of one or more polymorphic sites in a target nucleic acid sequence. The method comprises determining changes in the melting profile of an amplified product where the amplified product was amplified with a primer pair where one of the primers... Agent: Townsend And Townsend And Crew, LLP

20060281086 - Recovery of dna: The invention provides a method for recovery of cDNA from mRNA, comprising reverse transcription (RT) of mRNA using a RT primer which includes a sequence based on the 5′ consensus region of the mRNA which is identical or similar to 5′ consensus region of the mRNA and which includes a... Agent: Goodwin Procter LLP Patent Administrator

20060281120 - Susceptibility genes for age-related maculopathy (arm) on chromosome 10q26: Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development of ARM in an individual that comprises identification of allelic variations in PLEKHA1 and/or LOC387715. Related apparatus, such as an... Agent: Jesse A. Hirshman, Esq.

20060281106 - Telomerase promoter sequences for screening telomerase modulators: Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is turned off in mature differentiated cells, but is turned back on again in hyperplastic diseases, including many cancers. This disclosure provides regulatory elements that promote... Agent: Geron Corporation

20060281100 - Thiotriphosphate nucleotide dye terminators: Fluorescent reporter compounds having a chain terminating (thio)triphosphate nucleotide derivative, a fluorescent dye, and a linker of sufficient length to connect the nucleotide derivative to the fluorescent dye are provided. The fluorescent reporter compounds are used in DNA sequencing reactions and are substantially inactive toward exonuclease digestion.... Agent: Beckman Coulter Inc. C/o Sheldon Mak Rose & Anderson

20060281087 - Titanium dioxide complex having molecule distinguishability: A titanium dioxide composite having a molecular recognition capacity is obtained by modifying the surface of a fine titanium dioxide particle with a hydrophilic polymer in such a manner that titanium dioxide is bonded via an ester bond to a carboxyl group of the hydrophilic polymer and immobilizing a molecule... Agent: Ladas & Parry

20060281134 - Method for analyzing biological data sets: The present invention relates to methods for analyzing biological data sets, and more specifically for identifying biomolecular differences between biological samples. In particular, the present invention is based in part, on the discovery that Markov's Inequality, and in certain illustrative aspects Chebyshev's Inequality, can be used to analyze biological data... Agent: Biotechnology Law Group C/o Portfolioip

20060281132 - Method of immunoreaction measurement and, for use therein, reagent, kit and optical cell: In the present invention, there is provided a method for measuring, under an acidic pH condition, a subject substance in a specimen. The method includes: step A for forming a reaction system by mixing the specimen and an antibody against the subject substance in the specimen; and step B for... Agent: Wenderoth, Lind & Ponack L.L.P.

20060281135 - Methods for diagnosing and treating cerebrovascular events based on nr2 peptides: Methods and kits for diagnosing and treating cerebrovascular events, and for defining the time and anatomical location of an event, are provided based on the detection and quantification of bound or total and unbound NR2 peptides in biological fluids. The methods are optionally performed in conjunction with neurological scoring and... Agent: King & Spalding LLP

20060281130 - Metod of modulation of interaction between receptor and ligand: The present invention relates to a method for modulating the interaction between at least two proteins, wherein at least one of the two proteins is a functional cell-surface receptor and the other protein is the receptor ligand. The invention features a binding site of said functional cell-surface receptor on the... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20060281131 - Novel anti-feline albumin antibodies and methods of detecting early renal disease: The present invention provides isolated monoclonal antibodies that selectively bind albumin from animals. Also provided are methods using such antibodies for the detection of early renal disease in animals. The method includes the steps of (a) obtaining a sample from an animal to be tested; (b) contacting the sample with... Agent: Heska Corporation Intellectual Property Dept.

20060281133 - Targeted fusion proteins and methods for the characterization of cellular membrane domains: Cell membranes containing glycolipid-enriched membrane (GEM) and non-glycolipid-enriched membrane (non-GEM) domains are targeted using fusion proteins that are anchored in the cell membrane. Fusion proteins to target GEM (or non-GEM) domains are comprised of a selected fluorescent polypeptide, a membrane-targeting sequence of p56Lck (or pp60c-Src for non-GEM domains) and a... Agent: Fulbright & Jaworski L.L.P.

20060281137 - Method of the discrimination and isolation of mammary epithelial stem and colony-forming cells: The present invention relates to an improved method that permits the differential isolation of mouse mammary stem cells and colony forming cells (CFCs). The method involves depletion of non-epithelial cells from freshly dissociated mouse mammary tissue by incubation with an antibody composition containing antibodies specific for CD45, Ter119, CD35 and... Agent: Bereskin And Parr

20060281136 - Preparation of endodermal stem cells: It is intended to prepare endodermal stem cells by differentiation from multipotential stem cells followed by isolation. This object can be achieved by separating various endodermal stem cells having been differentiated from multipotential stem cells with the use of, as indications, a specific cell surface marker, an organizer-specific marker and... Agent: Sterne, Kessler, Goldstein & Fox PLLC

20060281138 - Methods for diagnosis of low grade astrocytoma: A method for identifying low grade astrocytoma cells in a sample is provided, wherein the method distinguishes between low grade astrocytoma cells and normal astrocytes, thus permitting early diagnosis of astrocytoma. The method uses antibody directed against JI-31 to test astrocytes in the sample for the presence or absence of... Agent: Christie, Parker & Hale, LLP

20060281139 - Carrier and method for the detection of anti-borrelia antibodies and test kit for use in the diagnosis of lyme borreliosis infections: The invention relates to a carrier and a method for the detection of anti-Borrelia antibodies and a test kit for use in the diagnosis of Lyme borreliosis infections.... Agent: Marshall, Gerstein & Borun LLP

20060281140 - Coagulation tests at ambient temperature: A method of determining prothrombin time (PT) in a whole blood, anti-coagulated blood, blood plasma or anti-coagulated blood plasma sample at an ambient temperature in the range of 15° C. to 45° C. is described. The method is performed with liquid reagents and the PT, preferably expressed as International Normalized... Agent: Bacon & Thomas, PLLC

20060281141 - Method for isolating potential antibiotic microorganisms: The present invention provides a method identifying nonparaffinophilic microorganisms suitable for antibiotic screening. The method provides the growing of nonparaffinophilic microorganisms on substrates in a bioreactor, wherein the bioreactor provides an environment conducive to the metabolism of many nonparaffinophilic microorganisms while being restrictive to methanogens and methane production. The method... Agent: Eckert Seamans Cherin & Mellott

20060281142 - Combined sample enrichment and disruption: A process of preparing a sample for analytical testing, comprising enriching and/or growing the sample in an enrichment/growth medium in a vessel; and disrupting the sample to release the intracellular contents of the sample, wherein the disruption is carried out in the same vessel as the enriching and/or growing. The... Agent: Patent Group Attn: J. Kenneth Joung

20060281143 - Method and apparatus for automatic cell and biological sample preparation and detection: A system identifies or screens one or more biological materials. The system includes at least one bioreactor adapted to provide biological samples and an automated sample handler comprising at least one bi-directional pump to transport biological samples, reagents and fluids, at least one reaction chamber with at least two regions... Agent: Westman Champlin & Kelly, P.A.

20060281144 - Method for utilizing nonparaffinophilic microorganisms for producing specific waste degradation: The present invention provides a method identifying nonparaffinophilic microorganisms suitable for biodegradation or bioremediation that do not substantially produce methane. The method provides the growing of nonparaffinophilic microorganisms on substrates in a bioreactor, wherein the bioreactor provides an environment conducive to the metabolism of many nonparaffinophilic microorganisms while being restrictive... Agent: Eckert Seamans Cherin & Mellott

20060281145 - Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins: Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose 6-phosphate (M6P), or other oligosacharides bearing other terminal hexoses, to carbonyl groups on oxidized glycans of glycoproteins while retaining their biological activity are described. The methods are useful for modifying glycoproteins, including those produced by recombinant protein expression systems, to... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060281148 - Cell-free extracts and synthesis of active hydrogenase: Enzymatically active hydrogenase is synthesized in a cell-free reaction. The hydrogenases are synthesized in a cell-free reaction comprising a cell extract derived from microbial strains expressing at least one hydrogenase accessory protein. In some embodiments, the extracts are produced under anerobic conditions.... Agent: Bozicevic, Field & Francis LLP

20060281146 - Novel compositions and methods for the treatment of immune related diseases: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.... Agent: Genentech, Inc.

20060281150 - Preparing membrane receptors from extracellular baculoviruses: A method of determining whether a membrane receptor expressed in recombinant extracellular baculoviruses is active, the method comprising: providing recombinant extracellular baculoviruses expressing a membrane receptor; contacting the extracellular baculoviruses with a ligand to the membrane receptor; and determining whether binding of the ligand to the receptor occurs, wherein said... Agent: Nixon & Vanderhye, PC

20060281147 - Thrombin-like recombinant baxtroxobin expressed by pichia sp.and production method thereof: A recombinant thrombin-like enzyme batroxobin expressed by yeast, a production method thereof, and use of the batroxobin as a hemostatic agent or antithrombotic agent is disclosed. In order to express recombinant thrombin-like enzyme, an expression vector is prepared by inserting cDNA encoding the enzyme, the transformed cell is prepared by... Agent: The Rafferty Patent Law Firm

20060281149 - Transforming growth factor-beta-related molecules and uses thereof: The present invention provides Transforming Growth Factor-Beta-Related (TGF-β-R) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing TGF-β-R polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders,... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20060281151 - Globular adiponectin variants: An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the adiponectin variant is not glycosylated, the adiponectin variant does not have residues 1-100 relative to human adiponectin, and wherein the solubility of the variant is improved by at least 3-fold relative to... Agent: Xencor

20060281152 - Glycosaminoglycans derived from the k5 polysaccharide having high anticoagulant and antithrombotic activity and process for their preparation: Glycosaminoglycans derived from the K5 polysaccharide having high anticoagulant and antithrombotic activity obtained by a process comprising the preparation of the K5 polysaccharide from Escherichia coli, N-deacetilation/N-sulfation, C-5 epimerization, supersulfation, selective O-desulfation, selective 6-O sulfation and N-sulfation, wherein said epimerization is carried out using the glucuronosyl C-5 epimerase enzyme in... Agent: Abelman, Frayne & Schwab 10th Floor

20060281153 - Methods and kits for sense rna synthesis: Methods and kits are provided for performing multiple rounds of sense RNA synthesis. The sense RNA molecules can be used in various research and diagnostic applications, such as gene expression studies involving nucleic acid microarrays.... Agent: Datascope Investment Corp.

20060281154 - Enzymatic depolymerisation of carboxymethylcellulose in hydroalcoholic solutions: The present invention refers to the procedure for the preparation of aqueous concentrated solutions of low viscosity carboxymethylcellulose by enzymatic depolymerisation of medium viscosity carboxymethylcellulose in the form of dispersed powder in a hydro-alcoholic heterogeneous medium, and to such aqueous concentrated solutions which have Brookfield viscosity, at 20° C. and... Agent: Paul S Madan Madan, Mossman & Sriram, PC

20060281155 - Microbial process for preparing pravastatin: wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6β-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The... Agent: Kenyon & Kenyon LLP

20060281156 - Method for producing non-amino organic acid: Non-amino organic acids such as succinic acid, malic acid and fumaric acid are produced by reacting bacterial cells or treated bacterial cells of a coryneform bacterium with an organic raw material in an aqueous medium containing magnesium carbonate and/or magnesium hydroxide, and a certain range of concentration of a monovalent... Agent: Greenblum & Bernstein, P.L.C

20060281157 - Dry solids staging fermentation process: A dry solids staging fermentation process for producing an end-product, such as ethanol is disclosed said process including an initial fermentation step including combining a first fermentable substrate with one or more starch hydrolyzing enzymes and fermenting organisms in a fermentation vessel and a loading step which includes adding a... Agent: Lynn Marcus-wyner Genencor International, Inc.

20060281159 - Method for sustained microbial production of hydrogen gas in a bioreactor: The present invention provides a method of hydrogen production from hydrogen producing microorganisms, wherein a bioreactor provides an environment conducive to the production of hydrogen from hydrogen producing microorganisms and restrictive to the production of methane from methanogens. The hydrogen producing microorganisms metabolize an organic feed material substrate, wherein the... Agent: Eckert Seamans Cherin & Mellott

20060281160 - Method of hydrogen production in a bioreactor having a circulation system: The present invention provides a method of hydrogen production from microorganisms, wherein a bioreactor provides an environment conducive to the production of hydrogen from hydrogen producing microorganisms and restrictive to the production of methane from methanogens. The environment adjusted to a pH conducive to the growth and metabolism hydrogen producing... Agent: Eckert Seamans Cherin & Mellott

20060281163 - Method of producing hydrogen gas in a bioreactor with substrates and associated apparatus: The present invention provides a method and apparatus of hydrogen production from microorganisms, wherein a bioreactor provides an environment conducive to the production of hydrogen from hydrogen producing microorganisms and restrictive to the production of methane from methanogens. The method and apparatus includes substrates contained within the bioreactor for growing... Agent: Eckert Seamans Cherin & Mellott

20060281158 - Production of hydrogen gas and isolation of hydrogen producing microorganisms using replenishing coated substrates: The present invention provides a system of baiting and growing microorganisms on a gelatinous matrix. A bioreactor is provided wherein the bioreactor provides an environment conducive to the breakdown of organic aqueous material and the production of hydrogen from microorganisms and restrictive to the production of methane from methanogens. The... Agent: Eckert Seamans Cherin & Mellott

20060281161 - Production of hydrogen gas in a bioreactor with a coated substrates: The present invention provides a system of baiting and growing microorganisms on a gelatinous matrix. A bioreactor is provided wherein the bioreactor provides an environment conducive to the breakdown of organic aqueous material and the production of hydrogen from microorganisms and restrictive to the production of methane from methanogens. The... Agent: Eckert Seamans Cherin & Mellott

20060281162 - System for sustained microbial production of hydrogen gas in a bioreactor: The present invention provides a system of hydrogen production from microorganisms, wherein a bioreactor provides an environment conducive to the production of hydrogen from hydrogen producing microorganisms and restrictive to the production of methane from methanogens. The environment is controlled by providing a pH controller for controlling the pH of... Agent: Eckert Seamans Cherin & Mellott

20060281164 - System for sustained microbial production of hydrogen gas in a bioreactor utilizing a circulation system: The present invention provides an apparatus for the production of hydrogen from microorganisms, wherein a bioreactor provides an environment conducive to the production of hydrogen from hydrogen producing microorganisms and restrictive to the production of methane from methanogens. The environment is adjusted to a pH conducive to the growth and... Agent: Eckert Seamans Cherin & Mellott

20060281165 - Method for stabilization of enzymes during exposure to sterilizing radation: The present invention provides a composition comprising an enzyme, e.g. oxidase enzyme, a source of zinc and/or ammonium ions and a source of lactate ions. The compositions are typically sterilised by exposing the compositions to sterilising radiation, e.g. gamma radiation. The incorporation of a source of zinc and/or ammonium ions... Agent: Morgan Lewis & Bockius LLP

20060281166 - Stabilization of t4 endonuclease v: The invention provides T4 endonuclease V compositions that exhibit enhanced stability, including stability at non-refrigerated temperatures, through reduced activity of cryptic proteases. Methods for detecting cryptic protease activity and methods for reducing such activity are also provided.... Agent: Maurice M Klee

20060281167 - Bacteria-based and enzyme-based mechanisms and products for viscosity reduction breaking of viscoelastic fluids: It has been discovered that fluids viscosified with viscoelastic surfactants (VESs) may have their viscosities reduced (gels broken) by the direct or indirect action of a biochemical agent, such as bacteria, fungi, and/or enzymes. The biochemical agent may directly attack the VES itself, or some other component in the fluid... Agent: Madan, Mossman & Sriram, P.C.

20060281168 - Cell fusion chamber, cell fusion device, and method for cell fusion using the same: The present invention relates to a cell fusion chamber in which two types of cells having different diameters are fused, the cell fusion chamber including: a cell fusion region in which cell fusion is carried out; a pair of electrodes formed by a conductor and disposed opposite to each other... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20060281169 - Analytical device for cell cultures: The present invention relates to an analytical device (1) for cell cultures comprising a container (4) for cell cultures, a reservoir (2) for the storage of fresh culture medium for said cell cultures, pumping means (3) suitable to introduce said fresh culture medium into said container and to remove metabolised... Agent: Merchant & Gould PC

20060281170 - Localized plasmon resonance sensor: A localized plasmon resonance sensor for detecting a change in optical constant uses a structure including metal. In a response spectrum with respect to light incident on the structure, there are at least two resonance peaks including at least one resonance peak shifted to a longer wavelength side and at... Agent: Fitzpatrick Cella Harper & Scinto

20060281171 - Fermentation unit with liquid nitrogen cooling: An integrated industrial plant includes various systems, all of which use a cryogenic liquid obtained from a common source. One system includes a fermentation unit, in which cold air, chilled by heat exchange with the cryogenic liquid, absorbs excess heat generated by the fermentation. Another system is a lyophilization unit,... Agent: Air Liquide

20060281172 - Cell culturel vessel, production process thereof and cultured cell: An object of the present invention is to provide a cell culture vessel which is simple in structure and easy to handle, and is capable of preventing damage to the cells when separated, promoting transport of nutrients and excretion of effete matter, and elevating the culturing efficiency improving effect by... Agent: Antonelli, Terry, Stout & Kraus, LLP

20060281173 - Composition for coating support for preparation of cell sheet support for preparation of cell sheet and process for producing cell sheet: Disclosed are a method for manufacturing a cell sheet, comprising culturing cells on a fibrin-coated surface of a substrate until the cells reach confluency, continuing the cultivation of the cells for a sufficient time period to cause the degradation of fibrin at the bottom of the cells, and detaching the... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20060281176 - In-vitro fertilization systems with spermatozoa separated into x-chromosome and y-chromosome bearing populations: An IVF system for successfully utilizing spermatozoa separated into X-chromosome bearing and into Y-chromosome bearing population for insemination. The IVF system includes fertilization medium that can shorten the time from insemination to cleavage and a portable incubator for the transportation of maturing oocytes and inseminated oocytes comprising a straw (19)... Agent: Santangelo Law Offices, P.C.

20060281174 - Methods for generating insulin-producing cells: This invention relates to methods for generating insulin-producing cells. In particular, the present invention relates to methods for generating insulin-producing cells or precursors thereof in vitro or in vivo by employing mesenchymal stem cells and pancreatic cells. Insulin-producing cells or precursors thereof created in accordance with the present methods, as... Agent: Philip S. Johnson Johnson & Johnson

20060281175 - Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina): The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20060281178 - Human stem cells originating from human amniotic mesenchymal cell layer: Neural stem cells which can be provided stably and which are free from the problem of compatibility in transplantation are disclosed. The stem cells are separated from human amniotic mesenchymal cell layer and express vimentin, nestin and BrdU which are markers of neural stem cells. The stem cells can also... Agent: Birch Stewart Kolasch & Birch

20060281177 - Method of isolating epidermal neural crest stem cells: The present invention describes novel methods for isolating a substantially pure cell population of non-embryonic epidermal neural crest stem cells from the bulge-region of mammalian hair follicles. Also disclosed is the substantially pure cell population of follicular bulge-derived neural crest stem cells for medical research and therapeutic use.... Agent: Quarles & Brady LLP

20060281179 - Inducer for differentiation of embryo stem cells into ectodermal cells method of obtaining the same and use thereof: A method for obtaining a solution having activity to induce differentiation of an embryonic stem cell into an ectodermal cell or ectoderm-derived cell, which comprises culturing a stromal cell in a culture comprising a polyanionic compound and recovering the culture; a solution having activity to induce differentiation of an embryonic... Agent: Fitzpatrick Cella Harper & Scinto

20060281180 - Vectors: Provided is a lentiviral vector capable of delivering a nucleotide of interest (NOI) to a desired target site and wherein the NOI encodes the Factor VIII and the Factor VIII is expressed following delivery of the NOI to the desired target site.... Agent: Frommer Lawrence & Haug

20060281181 - Adaptor-directed helper systems: The present invention provides adapter-directed display systems for expressing exogenous polypeptide within a host cell and/or displaying the exogenous polypeptide on the outer surface of a genetic package. This subject systems are particularly useful for displaying a genetically diverse repertoire of monomeric and multimeric polypeptides. The invention also provides both... Agent: Merck And Co., Inc

20060281182 - Electroporation apparatus and methods: This document discloses electroporation vessels, electrocompetent cells that have been aliquoted and frozen in electroporation vessels, and a number of other apparatuses, kits, and methods for electroporation. Some embodiments of electroporation vessels described herein may include a pair of opposing walls that are downwardly angled toward one another in a... Agent: Sterne, Kessler, Goldstein & Fox PLLC

20060275742 - Cardioplegic solution: A cardioplegic solution which contains a trehalose and one or more metal ions. The trehalose is preferably contained in an amount of not more than 3.5% (W/V), or 1.5 to 3.5% (W/V). The metal ions are preferably Na+, K+, Mg++ and Ca++. The cardioplegic solution is useful for cardiac standstill... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060275743 - Counting, viability assessment, analysis and manipulation chamber: A transparent plastic slide has a recessed chamber which receives a transparent plastic cover. The cover has a fluid inlet opening which overlies a recessed center well in the slide. The well has a sloping ramp which extends to a viewing platform which has a surface which is closely spaced... Agent: Whyte Hirschboeck Dudek S C

20060275745 - Method for optically determining dynamic behaviour of contracting muscle cells: The invention refers to a method for optically determining the dynamic behaviour of contracting muscle cells, such as cardiomyocytes in a cell culture, for example, wherein a video sequence of the contracting muscle cells is made using a video camera (3), an image processing unit (4) is used to calculate... Agent: Shumaker & Sieffert, P. A.

20060275744 - Modified human embryonic stem cells and methods of use to treat neuron-associated disorders: The invention is directed to methods for promoting the differentiation and maturation of embryonic and adult stem cells to dopamine neurons by increasing expression of the transcription factors Nurr1 and PitX3 in the stem cells. The invention provides embryonic and adult stem cells expressing Nurr1 and PitX3 from nucleic acid... Agent: Wilmer Cutler Pickering Hale And Dorr LLP Columbia University

20060275750 - Bioreactive agents: This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions. Agents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise agents... Agent: Peter G. Carroll Medlen & Carroll, LLP

20060275749 - Compositions for use in identification of orthopoxviruses: Oligonucleotide primers and compositions and kits containing the same for rapid identification of orthopoxviruses by amplification of a segment of viral nucleic acid followed by molecular mass analysis are provided.... Agent: Medlen & Carroll LLP

20060275747 - Endogenous retrovirus up-regulated in prostate cancer: A specific member of the HERV-K family located in chromosome 22 at 20.428 megabases (22q11.2) has been found to be preferentially and significantly up-regulated in prostate tumors. The invention provides methods for diagnosing prostate cancer, comprising the step of detecting in a patient sample the presence or absence of an... Agent: Novartis Vaccines And Diagnostics Inc.

20060275748 - Integrase cofactor: In a study of HIV-1 integrase (IN) complexes derived from nuclei of human cells stably expressing the viral protein from a synthetic gene it was demonstrated that in the nuclear extracts IN exists as part of a large distinct complex with apparent Stokes radius of 61 Å, which dissociates upon... Agent: Clark & Elbing LLP

20060275754 - Method for a rapid test: The object of the invention is a method for a rapid test. In the method in accordance with the invention a particle reagent is placed into a separate sample or reagent receptacle or test tube, in which the particle reagent reacts with one or several analytes in the liquid sample,... Agent: Harrington & Smith, LLP

20060275751 - Methods and compositions for screening using diphtheria toxin constructs: The invention relates to methods and compositions utilizing diphtheria toxin for screening purposes. The invention is particularly useful in screening for modulators of IgE synthesis, secretion and switch rearrangement.... Agent: Bozicevic, Field & Francis LLP

20060275752 - Multiparameteric method for assessing immune system status: The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a... Agent: Leydig Voit & Mayer, Ltd

20060275746 - Peptides which enhance transport across tissues and methods of identifying and using the same: A method of identifying a peptide which permits or facilitates the transport of an active agent through a human or animal tissue. A predetermined amount of phage from a random phage library or preselected phage library is plated unto or brought into contact with a first side, preferably the apical... Agent: Synnestvedt & Lechner LLP

20060275753 - Recovery of analytes using combinatorial libraries: The invention provides a method of binding multiple targets in samples by binding to multiple ligands. The method comprises providing ligands attached to a support, and contacting the ligands with targets to produce at least two target-ligand-support complexes. The method further comprises removal of non-bound targets followed by elution of... Agent: Merchant & Gould PC

20060275812 - Assay for agonists and antagonists of ion channels and for regulators of genetic expression: The invention provides an assay for agonists and antagonists of ion channels and for regulators of genetic expression.... Agent: Leydig Voit & Mayer, Ltd

20060275793 - Association between markers in the leptin gene and carcass traits in commercial feedlot steer and heifers: The invention provides a method for sub grouping animals according to genotype wherein the animals of each sub-group have a similar polymorphism or combination of polymorphisms in the leptin gene, the single nucleotide polymorphisms being selected from the group consisting of UASMS1, UASMS2, UASMS3, EXON2-FB, and E2JW. The combination of... Agent: Judy Jarecki-black, Ph.d,j.d

20060275791 - Biological control of nanoparticle nucleation, shape and crystal phase: The present invention includes compositions and methods for selective binding of amino acid oligomers to semiconductor and elemental carbon-containing materials. One form of the present invention is a method for controlling the particle size of the semiconductor or elemental carbon-containing material by interacting an amino acid oligomer that specifically binds... Agent: Foley And Lardner LLP Suite 500

20060275796 - Canine herpesvirus thymidine kinase nucleic acid molecules: The present invention includes novel recombinant canine herpes virus (CHV) and novel recombinant CHV genomes, and particularly to those CHV and CHV genomes that contain heterologous nucleic acid molecules. The present invention also relates to the use of such genomes and viruses in a variety of applications, including as therapeutic... Agent: Heska Corporation Intellectual Property Dept.

20060275813 - Cartridge for chemical reaction: The cartridge for chemical reaction according to the invention is a cartridge for chemical reaction that causes chemical reaction by feeding an internal liquid by way of deformation caused by external forces. The entirety of a target molecule detecting chip is housed in the cartridge for chemical reaction. According to... Agent: Sughrue Mion, PLLC

20060275794 - Collections of matched biological reagents and methods for identifying matched reagents: Provided herein are collections of matched biological reagents selected from a larger collection of biological reagents, wherein the collection of matched biological reagents relate to a biological element. Also provided are methods for selling an isolated biomolecule or biological research reagent in a collection of matched biological reagents, and methods... Agent: Biotechnology Law Group C/o Portfolioip

20060275787 - Compositions and methods for array-based genomic nucleic acid analysis of biological molecules: The invention provides biological molecules modified by reaction with a compound having the formula: R1—X—R2 , wherein R1 is a cyclic ether group or an amino group, R2 is an alkoxysilane group and X is a moiety chemically suitable for linking the cyclic ether group or the amino group to... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20060275799 - Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation: Disclosed are methods of for constructing a bead-displayed library of oligonucleotide probes (or sequence-modified capture moieties such as protein-nucleic acid conjugates) by ligation of a capture probe, having an analyte-specific sequence, to an anchor probe that is attached, at its 5′-end, (or possibly at the 3′ end) to an encoded... Agent: Eric P. Mirabez

20060275780 - Cross-linking reagents and uses thereof: A method of cross-linking a polynucleotide to a target compound. The method comprises (1) providing a polynucleotide and a target compound, and (2) contacting the polynucleotide and the target compound with a photoreactive cross-linking agent under conditions that allow cross-linking of the polynucleotide to the target compound. Also disclosed is... Agent: Hogan & Hartson L.L.P.

20060275784 - Detection of human papilloma virus in papanicolaou (pap) smears: Methods and reagents for detecting high-risk human papilloma virus (HPV) DNA types in cells on a Pap smear which indicates the patient is at higher risk for cancer are described. The method differentiates high-risk from low-risk HPV DNA in cells, which indicates the patient's risk for cancer.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20060275782 - Detection of nucleic acid reactions on bead arrays: The present invention is directed to methods and compositions for the use of microsphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e. the determination of the sequence of nucleic acids, particularly alterations such as nucleotide substitutions (mismatches) and single nucleotide... Agent: Mcdermott, Will & Emery

20060275798 - Detection of organisms using a media sachet and primer directed nucleic acid amplification: A method of detecting a target organism in a sample mixture comprising preparing at least one complex sample mixture, performing primer directed nucleic acid amplification of the complex sample mixture; and examining the primer directed nucleic acid amplification result to detect for presence or absence of amplification product of the... Agent: Patent Group Attn: J. Kenneth Joung

20060275795 - Determination and potential control of pathogenic bacteria or bacterial strains: The present invention is directed to methods to detect and/or determine bacterial pathogenicity and species identity based on genes that encode transcriptional regulators or putative transcriptional regulators.... Agent: Dla Piper US LLP Attn: Patent Group

20060275789 - Direct multiplex characterization of genomic dna: The invention is directed to novel methods of multiplexing nucleic acid reactions, including amplification, detection and genotyping. The invention relies on the use of precircle probes that are circularized in the presence of the corresponding target nucleic acids, cleaved, and then amplified.... Agent: Fish & NeaveIPGroup Ropes & Gray

20060275756 - Displacement assay for detecting ligate-ligand association events: Described is a method for detection of ligate-ligand association events, the method comprising the steps: providing a modified surface, the modification consisting in the attachment of at least one type of ligate; providing signal ligands; providing a sample having ligands; bringing a defined quantity of the signal ligands into contact... Agent: Crockett & Crockett

20060275786 - Electrochemical detection of dna binding: In one aspect, the invention provides methods and apparatus for detecting a protein binding to a nucleic acid by measuring the impedence of a nucleic acid layer on an electrode, for example by AC impedance spectroscopy. In one embodiment, such methods may for example be used to detect a mismatch... Agent: Bozicevic, Field & Francis LLP

20060275792 - Enhancement of nucleic acid amplification using double-stranded dna binding proteins: Disclosed are methods and materials for enhancing the efficiency, specificity and/or specificity of nucleic acid amplification reactions (e.g., PCR amplification reactions). The disclosed inventions involve the use of nonspecific double-stranded DNA binding proteins in amplification reactions. The methods described herein are useful in a wide variety of molecular biology applications... Agent: Sterne, Kessler, Goldstein & Fox PLLC

20060275804 - Enzymes having dehalogenase activity and methods of use thereof: The invention relates to haloalkane dehalogenases and to polynucleotides encoding the haloalkane dehalogenases. In addition methods of designing new dehalogenases and method of use thereof are also provided. The dehalogenases have increased activity and stability at increased pH and temperature.... Agent: Diversa C/o Mofo S.d.

20060275810 - Focused microarray and methods of diagnosing chemotherapeutic drug resistance in a cancer cell: Disclosed are methods for diagnosing chemotherapeutic drug resistance in a cancer cell sample by detecting an increase in the levels of expression of marker genes in the cancer cell sample as compared to the levels of expression of the same marker genes in a chemotherapeutic drug-sensitive cancer cell of the... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20060275765 - G-proteins: Gαq-Gustducin chimeric G-proteins that functionally couple to G-protein coupled receptors. The chimeras can be expressed in heterologous cell systems and can be used as the basis of assays for identifying modulators of taste response, in particular bitter, sweet or umami taste responses.... Agent: Norris, Mclaughlin & Marcus

20060275783 - Gene markers for lung cancer: A method for the diagnosis and identification of new or residual lung cancer is disclosed which uses newly identified markers for lung cancer including syndecan 1, collagen 1 alpha 2, and two novel proteins, 7013 and 7018. The method involves identification of the lung cancer markers is blood from a... Agent: Knobbe Martens Olson & Bear LLP

20060275819 - Guanylate-binding protein: A member of the guanylate-binding protein family, designated GBP-4, is provided. Also provided are isolated nucleic acid encoding GBP-4, vectors and host cells containing such nucleic acid molecule, and a method for producing the GBP-4 recombinantly.... Agent: Gates & Cooper LLP Howard Hughes Center

20060275770 - Heart failure gene determination and therapeutic screening: Genes implicated in the progression of heart failure and in the endogenous myocardial recovery and repair mechanism provide the basis for screening potential therapeutic compounds for use as pharmaceutical preparations for the treatment of congestive heart failure. Target genes or target gene products whose expression level or biological activity are... Agent: Foley And Lardner LLP Suite 500

20060275775 - Intramolecularly-quenched near infrared fluorescent probes: An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation... Agent: Fish & Richardson PC

20060275790 - Kcnq5, a novel potassium channel: The invention provides isolated nucleic acid and amino acid sequences of KCNQ5, antibodies to KCNQ5, methods of detecting KCNQ5, methods of screening for potassium channel activators and inhibitors using biologically active KCNQ5, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising KCNQ5.... Agent: Townsend And Townsend And Crew, LLP

20060275767 - Kinase sequences useful for developing compounds for the prevention and/or treatment of metabolic diseases and nucleotide sequences encoding such kinase sequences: The present invention relates to nucleotide sequences that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds with activity as pharmaceuticals, in particular of compounds for the prevention and treatment of metabolic diseases such as diabetes and obesity. The... Agent: Wolf Greenfield & Sacks, PC

20060275757 - Magnetic nanomaterials and methods for detection of biological materials: Biological material in a sample is reacted with a novel functionalized superparamagnetic Fe/Au nanoparticle that specifically binds to the biological material in solution to produce a magnetic particle/biological material complex. The biological material is detected upon application of an external magnetic field which separates the magnetic bound complex from other... Agent: Mueting, Raasch & Gebhardt, P.A.

20060275778 - Method and apparatus for molecular analysis using nanoelectronic circuits: Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned... Agent: Hewlett Packard Company

20060275779 - Method and apparatus for molecular analysis using nanowires: Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a nanowire operably coupling a first terminal and a second terminal and a nitrogenous material disposed on the nanowire. The nitrogenous... Agent: Hewlett Packard Company

20060275764 - Method for determining predisposition to manifestation of immune system related diseases: The present invention relates to methods for determining predisposition to a manifestation of immune system related diseases, in particular infections, associated with a mutation in the human MASP-2 gene. The invention also features oligonucleotides, polypeptides, peptide fragments and antibodies which are used in the above methods as well as for... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20060275766 - Method for manufacturing recombinant polyclonal proteins: The invention relates to a method for manufacturing a recombinant polyclonal protein composition, in particular a recombinant polyclonal antibody composition. The method comprises obtaining a collection of cells transfected with a library of variant nucleic acid sequences, wherein each cell in the collection is transfected with and capable of expressing... Agent: Edwards & Angell, LLP

20060275811 - Method for producing target substance capturing protein and method for selecting component materials thereof: A combination of polypeptide chains used as a plurality of target substance-binding domains are selected by: (1) reacting a target substance with a first polypeptide chain with a known target substance-binding domain to obtain a first complex; (2) reacting the first complex with a second polypeptide chain library composed of... Agent: Fitzpatrick Cella Harper & Scinto

20060275788 - Method for rapid detection and identification of bioagents: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent.... Agent: Medlen & Carroll LLP

20060275760 - Method for screening of a lipase having improved enzymatic activity using yeast surface display vector and the lipase: The present invention relates to a method for screening of the lipase having improved enzymatic activity using yeast surface display vector and the mutant lipase prepared by the same, more particularly to the method comprising; 1) cloning lipase gene into surface display vector, 2) preparing mutant lipase gene library of... Agent: Nath & Associates