Chemistry: molecular biology and microbiology inventions 12/06

20060292544 - Systems, methods, compositions and solutions for perfusing an organ: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.... Agent: Fish & NeaveIPGroup Ropes & Gray LLP

20060292546 - Herg channel-expressing cell: It is an object of the present invention to establish a method of establishing a cell with a remarkably high hERG channel expression level for use in predicting adverse effects based on hERG channel inhibition in research and development of drugs, and to thereby establish a highly sensitive and high... Agent: Darby & Darby P.C.

20060292547 - Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism: Chronic alcoholism is a diverse and heterogeneous disorder that can be dichotomized into cognitively intact and cognitively impaired subgroups. At a molecular level, ethanol has been shown to have both acute and chronic effects on: Membrane biophysical properties, Membrane composition and metabolism, Protein phosphorylation, Lipid metabolic signaling, Lipoprotein transport of... Agent: Lesavich High-tech Law Group, P.C.

20060292550 - Method for determining fish composition using bioelectrical impedance analysis: A method for determining the freshness of fish. The method includes applying electrodes to the fish, passing an electrical current between the electrodes, determining an impedance for tissue of the fish between the electrodes, and correlating the determined impedance with a freshness value to determine the freshness of the fish.... Agent: Alex Nolte

20060292545 - Moleculary imprinted polymers for extraction of components from foodstruffs: The present invention relates to a novel class of water compatible molecularly imprinted polymers (AquaMIPs) capable of selectively binding target molecules such as riboflavin, or analogues thereof, in water or aqueous media, their synthesis and use thereof in food processing and extraction or separation processes.... Agent: Young & Thompson

20060292549 - Psychotropic drug screening device based on long-term photoconductive stimulation of neurons: The invention pertains generally to the field of psychotropic drug discovery and neuroscience. More specifically, the invention refers to a device that allows the long-term stimulation of cultured neurons grown on a silicon die, thereby replacing the use of intact animal models. The device consists of a controlled sterile environment... Agent: Fish & Richardson P.C.

20060292548 - Trp8, a transient receptor potential channel expressed in taste receptor cells: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion... Agent: Nixon Peabody LLP - Patent Group

20060292551 - Anti-viral activity of cathelicidin peptides: The disclosure provides methods and compositions useful in the treatment of dermatitis and viral infections. The compositions comprise cationic peptides of the cathelicidin family including LL-37, related homologues, and variants thereof.... Agent: Buchanan, Ingersoll & Rooney LLP

20060292555 - Biofunctional magnetic nanoparticles for pathogen detection: This invention provides a method of detecting pathogens comprising the steps of: (a) contacting a sufficient amount of biofunctional magnetic nanoparticles with an appropriate sample for an appropriate period of time to permit the formation of complexes between the pathogens in the sample and the nanoparticles; (b) using a magnetic... Agent: Law Offices Of Albert Wai-kit Chan, LLC

20060292559 - Cell-based microarrays, and methods for their preparation and use: The present invention is in the field of chemistry and biotechnology. The present invention relates to cell-based microarrays, improved methods for forming such arrays, and methods for using such arrays in diagnostics, therapeutics and research. The invention particularly concerns microarrays in which ligands of a target cells are immobilized to... Agent: Edell, Shapiro & Finnan, LLC

20060292554 - Major coat protein variants for c-terminal and bi-terminal display: The invention provides compositions and methods for enhanced display of heterologous proteins on viral particles.... Agent: Merchant & Gould PC

20060292553 - Method for study of the genetic and functional variability of hiv and kit for using it: A method of analyzing a sample possibly containing an HIV virus, including a) extracting viral RNA in a biological sample that possibly contains an HIV virus; b) reverse transcription of the RNA obtained of (a) and amplification with a first pair of primers to obtain an amplified product of reverse... Agent: Ip Group Of Dla Piper US LLP

20060292552 - Method for the detection and multiplex quantification of analytes in a sample, using microspheres: The invention relates to a method for the detection and multiplex quantification of analytes in a sample, using functionalised microspheres, whereby said microspheres are magnetised after the sample has been brought into contact therewith. The inventive method is particularly suitable for the detection and multiplex quantification of several analytes by... Agent: Foley And Lardner LLP Suite 500

20060292556 - Method of detecting antibodies to hcv: A family of cDNA sequences derived from hepatitis C virus (HCV) are provided. These sequences encode antigens which react immunologically with antibodies present in individuals with non-A non-B hepatitis (NANBV), but which are absent from individuals infected with hepatitis A virus, or hepatitis B virus, and also are absent in... Agent: Novartis Vaccines And Diagnostics Inc.

20060292558 - Methods and apparatus for protein assay diagnostics: Automated protein assay apparatus and methods for measuring antibodies against an analyte are described. A standard mixture of one or more analytes is loaded into a capillary, the analytes are resolved by isoelectric focusing and immobilized in the capillary. Serum from a human or non-human subject under analysis is flowed... Agent: Roger O'neill Cell Biosciences

20060292557 - Methods and compositions for detecting herpes simplex virus type 2: The invention provides methods for sensitive and specific detection of anti-HSV-2 antibodies by depletion of cross-reactive (non-specific) antibodies in a biological sample that can lead to a false positive result. The invention also features compositions, including nucleic acids, polypeptides, and kits, for use in the methods of the invention.... Agent: Bozicevic, Field & Francis LLP

20060292585 - Analysis of methylation using nucleic acid arrays: Methods of analyzing DNA to determine the methylation status of a plurality of cytosines are disclosed. In one aspect genomic DNA is fragmented, fragments are circularized, the circles are treated with a methylation sensitive enzyme to enrich for circles with methylated sites or with a methylation dependent enzyme to enrich... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20060292607 - Analysis of tissue samples surrounding malignancies: The present invention provides a method for analyzing tissue from the surgical margin of resected tumor, and the use of such information to predict recurrence, survival, and treatment efficacy in cancer patients. Methods of treatment based thereon are provided.... Agent: Fulbright & Jaworski L.L.P.

20060292618 - Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance: The present invention is based on the discovery antigen-presenting cells (APCs) may be generated to have predetermined levels of expression of the intracellular enzyme, indoleamine 2,3-dioxygenase (IDO). Because expression of high levels of IDO is correlated with a reduced ability to stimulate T cell responses and an enhanced ability to... Agent: Kilpatrick Stockton LLP - M0351

20060292622 - Application of aprataxin gene to diagnosis and treatment for early-onset spinocerebellar ataxia (eaoh): The present invention provides polynucleotides and proteins, which are involved in early-onset spinocerebellar ataxia with ocular motor apraxia and hypoalbuminemia (EAOH); and methods of using the polynucleotides and/or proteins to treat and/or diagnose EAOH.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20060292588 - Assay systems, kits and methods for detecting microorganisms: The present invention relates to an assay system, kits and methods for detecting microorgansims (especially for M. tuberculosis) of suspected patient. The present invention also relates to an apparatus for performing the integration of thermal and magnetic control in the same apparatus to largely reduce the whole process of M.... Agent: Bruce H. Troxell

20060292574 - Automated vntr genotyping method: The invention provides an automated VNTR genotyping method using multiple variable-number tandem repeats (VNTRs) loci based on mycobacterial interspersed repetitive units (MIRU) undergoing multiplex PCR and high throughput MegaBACE® capillary electrophoresis system. The method uses fluorescent dyes of 6-carboxytetramethylrhodamine(TAMRA), 6-carboxy fluorescein (FAM) and 6-carboxy-2′,4,4′,5′,7,7′-hexachlorofluorescein (HEX) labeling PCR primers. The method... Agent: Birch Stewart Kolasch & Birch

20060292581 - Biosensor for small molecule analytes: A biosensor device for detecting small molecules analytes is provided. The device employs a first class of molecules, e.g., protein that binds to both the analyte and a second class of molecules, e.g., nucleic acid. The binding of the protein to the analyte and nucleic acid can be mutually exclusive,... Agent: Darby & Darby P.C.

20060292572 - Cell-type-specific patterns of gene expression: Among the methods, compositions, combinations and kits provided herein are those for determining gene expression levels in one or more cell types in heterogeneous cell samples, for identifying genes differentially expressed in different cell types, and for detecting a cell type in a sample from a subject. Also provided herein... Agent: Fish & Richardson, PC

20060292580 - Cleavage of nucleic acids: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a... Agent: Medlen & Carroll, LLP

20060292596 - Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens: A method of preventing or inhibiting infection by a parasite or virus in vivo comprising administering to a human in need thereof a parasite or virus mitogen in a sub-mitogenic amount sufficient to induce a protective immune response against the parasite or virus in the human.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060292598 - Cloning, sequencing and expression of a gene encoding an eukaryotic amino acid racemase, and diagnostic, therapeutic, and vaccination applications of parasite and viral mitogens: A method of preventing or inhibiting infection by a parasite or virus in vivo comprising administering to a human in need thereof a parasite or virus mitogen in a sub-mitogenic amount sufficient to induce a protective immune response against the parasite or virus in the human.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060292608 - Comparative genomic hybridization: Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substantially removed and/or their hybridization signals suppressed. The invention termed Comparative... Agent: Quine Intellectual Property Law Group, P.C.

20060292584 - Compositions and methods for accomplishing nucleotide depletion: Methods and compositions are provided that achieve depletion of a nucleotide pool by means of a phosphate-transferring enzyme such as a nucleoside phosphate or a polyphosphate glucokinase. Depletion of a nucleotide pool using a nucleoside kinase may additionally utilize a phosphotransferase in a second phosphate-transferring reaction.... Agent: Harriet M. Strimpel New England Biolabs, Inc.

20060292615 - Compositions and methods for detecting single gene copies in-situ: Compositions and methods are provided for detecting single copies of a gene in-situ using brightfield microscopy in detection of various target nucleic acid sequences, such as genes or nucleic acid of microorganisms in a cell. In particular, nucleic acid probes for various target nucleic acid sequences in a cell are... Agent: Wilson Sonsini Goodrich & Rosati

20060292604 - Compositions and methods for spinocerebellar ataxia: The autosomal dominant spinocerebellar ataxias (SCAs) represent a growing and heterogeneous clinical phenotype with ongoing discovery of causative etiologies. Methods: The authors collected DNA and clinically characterized a three-generation Filipino family segregating a dominant ataxia. Following elimination of several known SCA loci, a genome-wide linkage study was undertaken with additional... Agent: Jones Day

20060292628 - Compositions and methods involving direct write optical lithography: An improved optical photolithography system and method provides predetermined light patterns generated by a direct write system without the use of photomasks. The Direct Write System provides predetermined light patterns projected on the surface of a substrate (e.g., a wafer) by using a computer controlled means for dynamically generating the... Agent: Affymetrix Inc/ Attn: ChiefIPCounsel Legal Dept

20060292593 - Dendritic cell co-stimulatory molecules: A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments, fusion polypeptides/proteins and other functional derivatives, and transformed cells expressing B7-DC are useful in vaccine compositions and methods. Compositions and... Agent: Banner & Witcoff

20060292602 - Dna diagnostic screening for turner syndrome and sex chromosome disorders: The present invention encompasses methods, assays and kits for the diagnosis, screening and identification of Turner syndrome and other disorders of sexual differentiation in a human using single nucleotide polymorphisms present on the X and Y chromosomes.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20060292561 - Dna enzymes: Methods for the selection of novel signaling allosteric DNA enzymes are provided. In particular, fluorescent signaling allosteric DNA enzymes are described. The selection system is based on the cleavage of an ribonucleotide flanked by a fluorophore modified nucleotide and a quencher modified oligonucleotide. Both cis-acting and trans-acting allosteric DNA enzymes... Agent: Summa, Allan & Additon, P.A.

20060292578 - Dna polymerase blends and mutant dna polymerases: A thermostable DNA polymerase composition comprising at least two DNA polymerases, one of which is substantially reduced in 5′-exonuclease activity and one of which has 5′-exonuclease activity. This polymerase may be used in methods including, but not limited to, nucleic acid synthesis, DNA sequencing, nucleic acid amplification and cDNA synthesis,... Agent: Invitrogen Corporation

20060292595 - Electrochemiluminescence detection method for nucleic acid using intercalator: Disclosed is a method for detecting nucleic acid hybridization by using intercalator binding to hybridized nucleic acid, wherein oxidation-reduction of transition metallic complex is induced to cause electrochemiluminescence, thereby providing a method for detecting nucleic acid hybridization without a special labeling.... Agent: Fleshner & Kim, LLP

20060292589 - Fluorescent quenching detection reagents and methods: Oligonucleotide probes containing two labels are provided and are useful in hybridization assays. The probes can also contain a minor groove binding group.... Agent: David W. Parker

20060292591 - Genes from the 20q13 amplicon and their uses: The present invention relates to cDNA sequences from a region of amplification on chromosome 20 associated with disease. The sequences can be used in hybridization methods for the identification of chromosomal abnormalities associated with various diseases. The sequences can also be used for treatment of diseases.... Agent: Beyer Weaver & Thomas, LLP

20060292620 - Genes with es cell-specific expression: The present invention relates to a probe for selecting ES cells, which characteristically contains one of DNAs having base sequences depicted in SEQ ID Nos; 1, 2, 3, 4, 5, 6, 7 and 8, or DNAs having base sequences depicted in SEQ ID Nos; 9, 11, 13, 15, 17, 19,... Agent: Leydig Voit & Mayer, Ltd

20060292594 - Hdac inhibitors that promote brm expression and brm related diagnostics: The present invention provides screening methods for identifying BRM expression-promoting histone deacetylase (HDAC) inhibitors, diagnostic methods for determining the suitability of treatment of a candidate subject with a BRM expression-promoting HDAC inhibitor, and therapeutic methods for treating cancer cells in a patient with a BRM expression-promoting HDAC inhibitor. The present... Agent: Medlen & Carroll, LLP

20060292583 - High speed parallel molecular nucleic acid sequencing: A method and device is disclosed for high speed, automated sequencing of nucleic acid molecules. A nucleic acid molecule to be sequenced is exposed to a polymerase in the presence of nucleotides which are to be incorporated into a complementary nucleic acid strand. The polymerase carries a donor fluorophore, and... Agent: Klarquist Sparkman, LLP

20060292573 - Human orthologues of wart: The present invention relates in part to hWART nucleic acid molecules. The invention also relates in part to nucleic acid molecules encoding portions of hWART full-length proteins, nucleic acid vectors containing hWART nucleic acid molecules, recombinant cells containing such nucleic acid vectors, polypeptides purified from such recombinant cells, antibodies to... Agent: Foley And Lardner LLP Suite 500

20060292586 - Id-tag complexes, arrays, and methods of use thereof: The present invention relates to the detection of target sequences. Detection can be achieved through the use of ID-tag complexes. These ID-tag complexes are relatively stable in the absence of a target sequence. In the presence of a target sequence, the complexes dissociate and form new complexes or duplexes, which... Agent: Knobbe Martens Olson & Bear LLP

20060292606 - Identification of ligands by selective amplification of cells transfected with receptors: The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions. The present invention also relates to a method of identifying compounds which act as inverse agonists of the 5-HT2A receptor, the method comprising contacting a constitutively... Agent: Knobbe Martens Olson & Bear LLP

20060292609 - Interferon-beta gene therapy using an improved, regulated expression system: The present invention provides an improved, expression system for the regulated expression of an encoded protein or nucleic acid therapeutic molecule in the cells of a subject, for use in the treatment of disease. In particular, the present invention provides an improved, regulated gene expression system, and pharmaceutical compositions and... Agent: Foley And Lardner LLP Suite 500

20060292592 - Key probe compositions and methods for polynucleotide detection: The invention relates to compositions and methods for detection of nucleic acid sequences. The invention further relates to kit format of said compositions for detection of nucleic acid sequences. Oligonucleotide probes of the invention comprise a target binding sequence and a sequence at least partially complementary thereto, joined by an... Agent: Palmer & Dodge, LLP Kathleen M. Williams / Str

20060292619 - Method and algorithm for quantifying polynucleotides: Machine executable method of analyzing growth curve data to identify the transition from a baseline phase into a growth phase. Applications of the method include analysis of results from time-dependent monitoring of amplicon synthesis in a nucleic acid amplification reaction to quantify a starting amount of a nucleic acid template... Agent: Gen Probe Incorporated

20060292567 - Method and means for determining specific conditions or changes in the uterine epithelium and in the epithelium of other organs: In a method for determining specific conditions or changes in the endometrium or in the epithelium of other organs, RNA from a blood sample or tissue sample isolated and the expression or over expression of mRNA of at least one of β7-hCG, β6-hCG, and β6e-hCG is measured quantitatively in the... Agent: Gudrun E. Huckett Draudt

20060292564 - Method and nucleic acids for the analysis of breast cell proliferative disorders: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of breast cell proliferative disorders,... Agent: Davis Wright Tremaine, LLP

20060292605 - Method for highly sensitive nucleic acid detection using nanopore and non-specific nucleic acid-binding agent: Provided is a method of sensitively detecting nucleic acids in a nucleic acid sample, the method comprising: contacting the sample comprising the nucleic acid with a non-specific nucleic acid binding agent in an electrically conductive fluid medium; contacting the sample comprising the nucleic acid bound to the agent with a... Agent: Cantor Colburn, LLP

20060292566 - Method for optimising gene expressing using synonymous codon optimisation: The present invention discloses a method for modulating the quality of a selected phenotype that is displayed by an organism or part thereof and that results from the expression of a polypeptide-encoding polynucleotide by replacing at least one codon of that polynucleotide with a synonymous codon that has a higher... Agent: Heller Ehrman White & Mcauliffe LLP

20060292603 - Method for selecting a chemical entity from a tagged library: Disclosed is a method for determining the identity of a chemical entity having a preselected property. The chemical entity is identified from a library composed of a plurality of different chemical entities each appended to unique identifier tags. An anti-tag having the capability of specifically interacting with the unique identifier... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20060292569 - Method for selectively binding a substrate to sorbents by way of at least bivalent bonds: A method for the manufacture of at least one sorbent having at least two different groups, which are capable of binding, for the selective binding of a substrate, characterized in that it comprises the steps (i) to (ii): (i) determining at least two groups capable of binding a sorbent from... Agent: Stephen D Scanlon Jones Day

20060292612 - Method for the quality control of functionalized surfaces: The invention relates to a method which can be used to test firstly a reaction and secondly the distribution of functional groups on a surface. This method is employed in a situation that demands documentation or testing of a distribution of surface functionalization, which is as homogeneous as possible.... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20060292568 - Method of preparing dna fragments and applications thereof: The invention relates to a method of preparing DNA fragments and to the applications thereof, in particular for the hybridisation of nucleic acids. The inventive method is essentially characterised in that it consists of at least the following steps comprising: (a) preparation of double-stranded DNA fragments from a sample of... Agent: Lowe Hauptman Berner, LLP

20060292617 - Methods and compositions for analysis of microrna: The invention provides methods and systems for detecting and measuring microRNAs.... Agent: Wolf Greenfield & Sacks, PC

20060292613 - Methods and compounds for prevention and treatment of elevated intraocular pressure and related conditions: A GPCR-like protein is described, as well as inhibitory/antagonistic compounds and compositions comprising such inhibitors/antagonists of the protein. Such compounds may be used for treating elevated intraocular pressure and conditions associated with elevated intraocular pressure, such as glaucoma.... Agent: Darby & Darby P.C.

20060292597 - Methods for genotyping with selective adaptor ligation: The present invention provides methods for reducing the complexity of a nucleic acid sample to interrogate a collection of target sequences. Complexity reduction can be accomplished by fragmenting the nucleic acid sample with a restriction enzyme that has at least one variable position in the recognition sequence. In some aspects... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20060292582 - Methods for nucleic acid manipulation: A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor. The recombination intermediate is treated with a high fidelity... Agent: Welsh & Katz, Ltd

20060292624 - Methods for the electrochemical detection of multiple target compounds: A method of detecting two different target molecules through a single electrode is carried out by (a) providing a conductive oxidation-reduction reaction detection electrode; (b) contacting a sample suspected of containing a first and second target molecule to the electrode under conditions in which the first and second target molecules... Agent: Myers Bigel Sibley & Sajovec

20060292626 - Methods of analysis of allelic imbalance: Methods are provided for identification of genes that are imprinted. In another embodiment methods are provided for identification and analysis of genes whose expression shows allelic imbalance. The expression products transcribed from genes that are present in the genome as two or more alleles may be distinguished by hybridization to... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20060292565 - Methods of cardiovascular disease assessment in an individual: Methods for cardiovascular disease assessment in an individual comprise detecting the presence or absence of a fragment encoding a polymorphic alpha-2C (α2C DEL322-325) adrenergic receptor in a sample from an individual; and detecting the presence or absence of a fragment encoding a polymorphic beta-1 adrenergic receptor (β1Arg389) in a sample... Agent: Dinsmore & Shohl, LLP

20060292563 - Methods of diagnosing & treating diabetes and insulin resistance: The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels... Agent: Townsend And Townsend And Crew, LLP

20060292579 - Methods of enzymatic discrimination enhancement and surface bound double-stranded dna: Methods for discriminating between fully complementary hybrids and those that differ by one or more base pairs and libraries of unimolecular, double-stranded oligonucleotides on a solid support. In one embodiment, the present invention provides methods of using nuclease treatment to improve the quality of hybridization signals on high density oligonucleotide... Agent: Townsend And Townsend And Crew LLP

20060292614 - Methods of gene expression monitoring: The invention provides methods of monitoring expression of a plurality of genes in a cell or small population of cells. Preferred methods entail contacting an array of probes with a population of nucleic acids derived from a population of fewer than 1000 cells then determining the relative hybridization of the... Agent: Banner & Witcoff Ltd., Counsel For Affymetrix

20060292562 - Methods of identifying genomic and proteomic biomarkers for cystic fibrosis, arrays comprising the biomarkers and methods of using the arrays: Cystic fibrosis (CF) is the most common fatal autosomal recessive disease in the U.S. and is principally caused by the DF508 mutation the CFTR gene. The principal site of morbidity and mortality for this disease is the lung. We have used genomic and proteomic methods to identify ubiquitin carboxy terminal... Agent: Dla Piper US LLP Attn: Patent Group

20060292599 - Methods to detect lineage-specific cells: The present invention is based, at least in part, on methods to identify and quantify lineage-specific cells. The present invention provides methods of detecting lineage-specific cells in a biological sample, and monitoring the effectiveness of progenitor cell transfer in a subject. The invention further provides methods of determining an effective... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20060292600 - Methods, compositions and kits for the detection and monitoring of lung cancer: Compositions and methods for the diagnosis of lung cancer are disclosed. Such methods are useful to detect early tumors or provide adequate stage/grade information or tumor specificity. Compositions may comprise one or more lung tumor proteins, teins, immunogenic portions thereof, or polynucleotides that encode such portions. Such compositions may be... Agent: Seed Intellectual Property Law Group PLLC

20060292577 - Neoplasia-specific splice variants and methods: All neoplastic cells express a unique cell-surface ubiquinone (NADH) oxidase with protein disulfide-thiol isomerase with characteristic sensitivity to inhibition by capsaicin, sulfonylureas, adriamycin and certain other compounds. This neoplasia-specific protein is the translational expression production of a particular splice pattern: exon 4 is not translated to become part of the... Agent: Greenlee Winner And Sullivan P C

20060292590 - Nod nucleic acids and polypeptides: The present invention relates to the NOD proteins and nucleic acids encoding the NOD proteins. The present invention further provides assays for the detection of NOD polymorphisms and mutations associated with disease states, as well as methods of screening for ligands and modulators of NOD proteins.... Agent: Medlen & Carroll, LLP

20060292576 - Non-in situ hybridization method for detecting chromosomal abnormalities: The present invention provides methods of detecting chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases. In particular, the present invention provides advanced methods of performing DNA hybridization, capture, and detection on solid support. Invention methods are useful for the detection, diagnosis, predicting response to... Agent: Foley & Lardner LLP

20060292625 - Novel human leucine-rich repeat domain containing protein hllrcr-1: The present invention provides novel polynucleotides encoding HLLRCR-1 polypeptides, fragments and homologues thereof Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HLLRCR-1 polypeptides to the diagnosis, treatment, and/or prevention... Agent: Louis J. Wille Bristol-myers Squibb Company

20060292575 - Novel method for diagnosing pathogens of sexually transmitted diseases: The present invention provides a novel method for diagnosing various pathogens of sexually transmitted diseases from one test sample. The method comprises amplifying the DNA fragments of the various pathogens synchronously by using one primer set and identifying the amplified DNA fragments with specific probes. This invention also provides a... Agent: Troxell Law Office PLLC One Skyline Place

20060292570 - Novel synthetic binding pairs and uses thereof: Derivatized cucurbiturils can be efficiently prepared and utilized for forming cucurbituril assemblies. These cucurbituril assemblies, in turn, can form affinity binding pairs with polyamines structures that are designed capable of binding to these assemblies. The resulting affinity pairs are highly advantageous over the presently known affinity pairs and therefore can... Agent: Martin D. Moynihan Prtsi, Inc.

20060292611 - Paired end sequencing: The present invention provides for a method of preparing a target nucleic acid fragments to produce a smaller nucleic acid which comprises the two ends of the target nucleic acid. Specifically, the invention provides cloning and DNA manipulation strategies to isolate the two ends of a large target nucleic acid... Agent: Mintz Levin Cohn Ferris Glovsky & Popeo

20060292627 - Pb39, a gene dysregulated in prostate cancer, and uses thereof: A novel gene, PB39, that is up-regulated, or over-expressed, in prostate cancer has been identified. The gene has been identified by means of its cDNA obtained by reverse transcription of the corresponding mRNA. Microdissection of prostate glands that had been surgically removed from prostate cancer patients revealed a novel up-regulated... Agent: National Institutes Of Health C/o Venable LLP

20060292587 - Polynucleotides encoding insect voltage-gated chloride channel and uses thereof: The instant invention provides nucleic acids encoding insect chloride channel (CLC channel), as well as CLC channel polypeptides encoded thereby. The invention further provides methods of identifying agents that modulate a level of CLC channel mRNA, polypeptide, or calcium ion channel activity. Such agents are candidate insecticidal compounds.... Agent: Bozicevic, Field & Francis LLP

20060292610 - Prognostic meta signatures and uses thereof: The present invention relates the novel statistical analyses of gene expression data. In particular, the present invention provides prognostic meta signatures (e.g. representing cancer samples) that identify genes with altered expression across several studies.... Agent: Medlen & Carroll, LLP

20060292571 - Quantification schemes for quantifying nucleic acids: Method and apparatus, including computer program products, implement techniques for quantifying a target nucleic acid (target) in a test sample. The techniques include providing a target and a defined initial amount of an internal control nucleic acid (control) different from the target; amplifying the target and control in a common... Agent: Roche Molecular Systems Inc Patent Law Department

20060292621 - Randomized libraries of zinc finger proteins: The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes.... Agent: Robins & Pasternak

20060292601 - Rapid genotyping analysis and the device thereof: The present invention discloses the use of Allele-Specific-oligonucleotide (ASO) as a detection assay for human HLA classification. Using Reversed-Dot-Blotting format and flow through hybridization process, more efficient, faster and less expensive HLA classification can be achieved. A simplified procedure for HLA genotyping is also described. This invention further provides a... Agent: Law Offices Of Albert Wai-kit Chan, LLC

20060292623 - Signature genes in chronic myelogenous leukemia: The present invention relates to genetic markers whose expression is correlated with progression of CML. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate chronic phase individuals from those in blast crisis. The invention relates to methods of using these markers to distinguish these... Agent: Jones Day

20060292616 - Single molecule mirna-based disease diagnostic methods: The invention relates to compositions and methods for detecting and quantifying small RNA species such as miRNA, preferably associated with disease detection and diagnosis.... Agent: Wolf Greenfield & Sacks, PC

20060292560 - Transcription factor target gene discovery: The ability to rapidly define transcription factor target genes allows for the study of genetic cascades involved in development, physiology and disease. The presently descibed invention outlines the combination of novel chromosomal immunoprecipitation and molecular biology technologies fot the high-throughput in vico discovery and characterization of both known and unknown... Agent: Transgenetics, Inc.

20060292637 - Biomimetic systems consisting of lipid membranes bound to an electrically conducting substrate: The invention concerns lipids functionalized with a terminal C═C double bond which can be transformed into an anchor group for binding to a substrate surface. The invention further concerns lipids comprising such an anchor group for binding to a substrate surface. The invention also concerns self-assembled monolayers of lipids on... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20060292630 - Biosensor and method of analyte measuring: A biosensor capable of analyzing an object, such as antigen, antibody, DNA or RNA, through detection of magnetic field to thereby allow washout of unbound label molecules to be unnecessary, which biosensor is compact and available at low price, excelling in detection precision. Coils are arranged at an upper part... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060292629 - Chimeric polypeptides and their use: The present invention concerns chimeric molecules that contain a preferential polypeptidic region, consisting of a specific affinity for the binding to specific DNA sequences, of a preferential polypeptidic region consisting of a DNA modifying activity, and this chimeric molecule is capable to cross biological membranes due to the presence of... Agent: Ladas & Parry

20060292631 - Elastin peptide fingerprints and analysis methods for mmp12 related to copd: Methods for producing and using protein/peptide fingerprints, allowing identification and investigation of disease-associated proteins/peptides that can be linked to specific drug targets, or to specific drug target combinations. The methods are particularly useful for studies relating to Chronic Obstructive Pulmonary Disease (COPD), especially for the enzyme MMP12.... Agent: Fish & Richardson P.C.

20060292632 - Method for ascertaining the orientation of molecules in biological specimens: A method of ascertaining the orientation of molecules in a biological specimen by total internal reflection includes focusing illuminating light through an objective in different positions in a plane of a pupil of the objective so as to generate a plurality of respective differently oriented evanescent fields in the specimen.... Agent: Darby & Darby P.C.

20060292633 - Method for modulating process mediated by farnesoid activated receptors: Farnesyl pyrophosphate, the metabolically active form of farnesol, is a key precursor in the synthesis of cholesterol, carotenoids, steroid hormones, bile acids and other molecules involved in cellular growth and metabolism. A nuclear receptor has been identified that is transcriptionally activated by farnesol and related molecules. This novel signaling pathway... Agent: Foley & Lardner LLP

20060292636 - Monoclonal antibodies, hybridoma cell lines, methods and kits for detecting phytase: This invention relates to the field of immunology and more specifically relates to anti-phytase monoclonal antibodies, immunoassay methods, kits, and reagents, for the detection of a phytase from or derived from E. coli phytase, in particular, Quantum™ phytase. The invention further relates to hybridoma cell lines that produce anti-phytase monoclonal... Agent: Syngenta Biotechnology, Inc. Patent Department

20060292638 - Sequence #115 as a target for identifying weight modulating compounds: Sequence #115, a G protein-coupled receptor, has been identified as a target for identifying weight modulating compounds. Compounds that modulate sequence #115 may be useful for the treatment of obesity and cachexia. Cell-based and cell-free assays are described to identify compounds which bind to and/or activate or inhibit the activity... Agent: Hoffmann-la Roche Inc. Patent Law Department

20060292635 - Stably preserved microspheres: In accordance with the present invention, active carboxylic acid ester groups are coupled on the surfaces of microspheres so as to reduce protocols for microsphere processing, control side reactions, and stably preserve beads containing active carboxylic acid ester groups. Further, microspheres labeled with at least one fluorescent dye cage in... Agent: Reed Smith LLP

20060292634 - Structure for presenting desired peptide sequences: Means and methods for generating binding peptide associated with a suitable core region are disclosed, the resulting proteinaceous molecule and uses thereof. A solution to the problems associated with the use of binding molecules over their entire range of use. Binding molecules can be designed to accommodate extreme conditions of... Agent: Trask Britt

20060292640 - Diagnostic methods for the detection of risk of neurodevelopmental disorders: The present invention provides methods of identifying markers indicative of the risk of developing a neurodevelopmental disorder caused in part by antibody- or autoantibody-mediated damage of neural tissue, including autism spectrum disorder (ASD). The invention further provides methods of diagnosing whether an individual has a neurodevelopmental disorder, including an ASD,... Agent: Townsend And Townsend And Crew, LLP

20060292639 - Splice variant of the vanilloid receptor vr1a: The invention provides a splice variant of the vanilloid receptor termed “VR1A.” VR1A has a unique N-terminus as compared with wild type VR1. The invention provides nucleic acid sequences encoding VR1A, expression vectors for expressing VR1A, amino acid sequences of VR1A, antibodies against VR1A and methods of making and using... Agent: Woodcock Washburn LLP

20060292645 - Method and reagent for measuring kinase activity: A method of measuring the activity of a kinase to which imatinib mesylate can bind is described. In the method, a kinase contained in a sample, to which imatinib mesylate can bind, a substrate for the kinase, and ATP are mixed. A phosphate group of ATP is thereby transferred to... Agent: Brinks Hofer Gilson & Lione

20060292644 - Novel tumor-associated marker: The present invention provides monoclonal antibody-producing hybridomas designated 27.F7 and 27.B1. The invention provides a method of detecting TIP-2 antigen bearing cancer cells in a sample. The invention provides a method of detecting TIP-2 antigen on the surface of cancer cells. The invention provides a method for diagnosing cancer in... Agent: Cooper & Dunham LLP

20060292643 - Recognition molecules for the treatment and detection of tumours: The invention relates to recognition molecules directed towards tumors, and it also relates to pharmaceutical compositions comprising said recognition molecules, methods for the production of said recognition molecules, and to the use of said recognition molecules in the diagnosis and therapy of tumor diseases.... Agent: Millen, White, Zelano & Branigan, P.C.

20060292646 - Methods, biosensors, and kits for detecting and identifying fungi: Described herein are methods of detecting the presence or absence of fungi, for example, fungi growing on a sample, by contacting the sample with a substrate which is modified at least one fungal compound that is produced and/or secreted by the fungus. The substrate's modification, or lack thereof, indicates the... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20060292648 - Method of screening for inhibitors of osteopontin: Amino acids 136 to 142 and amino acids 162 to 168 of human osteopontin constitute two sites at which osteopontin interacts with α4 integrins. Products capable of disrupting those interactions are useful in therapy, particularly in the treatment of inflammatory diseases.... Agent: Glaxosmithkline Corporate Intellectual Property - Uw2220

20060292647 - Reflex supplemental testing - a rapid, efficient and highly accurate method to identify subjects with an infection, disease or other condition: The present disclosure concerns methods, compositions and apparatus for detecting pathogens and/or molecular markers. In a particular embodiment, the pathogen to be detected may be Mycobacterium bovis or any other Mycobacterium species that causes tuberculosis in a mammal. However, the disclosed methods are not limited and virtually any type of... Agent: Faegre & Benson LLP Patent Docketing

20060292641 - Immunoassay method: The present invention provides an immunoassay method easier in operation and smaller in fluctuation of reaction. The immunoassay method according to the present invention is an immunoassay method, which employs a sandwich method using a microchip having an antibody immobilized in the micro-flow channel thereof, comprising feeding a fluid mixed... Agent: Smith, Gambrell & Russell

20060292642 - Immunoassay of phosphorylated proteins: An immunoassay of phosphorylated isoforms (phosphoforms, phosphoisoforms) of peptides, proteins, or their various related forms is described. In one embodiment, a sandwich-type “two-site” immunoassays involving two different recognition antibody partners, in which one antibody is specific for the protein or peptide and the other is specific for a known or... Agent: Beckman Coulter, Inc.

20060292649 - Methods and apparatus for reference lab diagnostics: Automated protein assay apparatus and methods suitable for use in a reference lab are described. A screening test for a pathogen or disease condition is performed at the reference lab. If the results of the screening test are positive, a definitive assay is performed. One or more analytes are resolved... Agent: Roger O'neill Attn: Cell Biosciences

20060292650 - Spectroscopic analysis of a biological fluid reacted with an enzyme: An apparatus is presented for estimating the concentration of an analyte using a combined enzyme-spectroscopic method. Examples are provided for the detection of glucose and lactate. A sample of biological fluid is mixed or contacted with an enzyme specific to the analyte of interest, and the reacting fluid is probed... Agent: Knobbe Martens Olson & Bear LLP

20060292653 - Metal mediated fluorescence superquenching assays for detection of phosphorylation and dephosphorylation of quencher-labeled substrates: A method includes contacting an analyte; a phosphorylatable or dephosphorylatable substrate bound to a quencher; and a sensor that includes at least one fluorescent polymer complexed to one or more metal species; to form a composition; and determining the fluorescence of the composition, if any; wherein when the substrate is... Agent: Dla Piper US LLP Attn: Patent Group

20060292654 - Microwell plate: The shallower wells of a crystalisation plate in which it is intended to form crystals are part-spherical and of uniform wall thickness. The optical effect of the transparent plastics material from which the plate is moulded counter the distortion of a view through a microscope so that crystals viewed through... Agent: Akerman Senterfitt

20060292651 - Protein labelling with oº-alkylguanine-dna alkyltrnsferase: The present invention relates to methods of transferring a label from suitable substrates to O6-alkylguanine-DNA alkyltransferase (AGT) fusion proteins, to suitable fusion proteins, to suitable variants of AGT, and to novel labelled fusion proteins obtained. A protein of interest is incorporated into an AGT fusion protein, the AGT fusion protein... Agent: Wenderoth, Lind & Ponack, L.L.P.

20060292652 - Substrate detection assay: Methods and compositions for evaluating nicotinamide-releasing activities as well as cell and organism-based evaluation methods are provided herein.... Agent: Fish & Richardson PC

20060292655 - 2-o sulfatase compositions and methods of analyzing therewith: The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present... Agent: Wolf Greenfield & Sacks, PC

20060292656 - Lactamase amplification substrate: An amplifiable β-lactamase substrate is provided comprising an enzyme donor fragment of β-galactosidase linked to form a ring to a β-lactam ring that is a substrate for lactamase and upon opening of the β-lactam ring the enzyme donor fragment becomes linearized. The cyclic substrate only weakly binds to the enzyme... Agent: Peters Verny Jones & Schmitt, L.L.P.

20060292658 - Fluorescent compound: A water-soluble photoluminescent compound including a symmetrical skeletal structure of the formula (A) in which x may represent any integer, and in which the phenyl rings may be substituted, is disclosed. A protein detector comprising such a compound and a method of measuring the total dissolved protein content of a... Agent: Young Law Firm, P.C. Alan W. Young

20060292657 - Phex substrates and methods using same: A fluorogenic PHEX substrate comprising a peptide unit; a fluorophore unit capable of conferring fluorescence on said substrate attached to an amino acid residue at a first end of the peptide unit; and a quencher unit capable of providing intrarnolecular quenching of said fluorescence attached to an amino acid residue... Agent: Choate Hall & Stewart Patent Group

20060292660 - Preparations for diagnosis of pancreatic exocrine function: A preparation for the diagnosis of pancreatic exocrine function by determining the amount in which a substance administered to a subject or a degradation product or metabolite thereof migrates into the blood and/or is excreted out of the body, wherein the substance is carried by a carrier and released from... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20060292659 - Protease regulator screening assay: A polypeptide containing an anchor region, a protease recognition site, and a detectable signal region can be produced recombinantly and directly attached to a solid support. The polypeptide is useful for screening protease regulators, especially protease inhibitors.... Agent: Novartis Vaccines And Diagnostics Inc.

20060292661 - Electrochemical sensing assays involving drug metabolizing enzymes: Use of an electrochemical mediator to transfer electrons from an electrode to molecules of a mammalian oxidative drug metabolizing enzyme (DME) in solution is described, in particular to carry out assays to determine metabolism of a candidate drug by the DME. Transfer of electrons by the mediator is carried out... Agent: Heller Ehrman White & Mcauliffe LLP

20060292662 - Galleria mellonella derived composition for detecting peptidoglycan, a method for use thereof, and a diagnostic kit containing the same: The present invention relates to a composition for selectively detecting an extremely small amount of peptidoglycan in sample, a preparation method of the composition, and a detection kit for peptidoglycan. It is possible to quantify a small amount of peptidoglycan contained in human blood, tissue, body fluid, water or food,... Agent: Gifford, Krass, Groh, Sprinkle & Citkowski, P.c

20060292663 - Method of measuring lactate dehydrogenase activity in serum, and device for measuring lactate dehydrogenase activity in serum: A new electrochemical measurement method is provided that is excellent in accuracy in detecting LDH activity in a serum sample and shortens the time required for the detection. The method of measuring lactate dehydrogenase activity in serum includes: a first step (S1) of adding at least lactic acid, a coenzyme... Agent: Mcdermott Will & Emery LLP

20060292664 - Method and apparatus for detecting and quantifying bacterial spores on a surface: A method and an apparatus for detecting and quantifying bacterial spores on a surface. In accordance with the method: bacterial spores are transferred from a place of origin to a test surface, the test surface comprises lanthanide ions. Aromatic molecules are released from the bacterial spores; a complex of the... Agent: Alessandro Steinfl, Esq. C/o Ladas & Parry

20060292665 - Glutaryl amidases and their uses: The invention relates to a new class of isolated, single or multiple mutated glutaryl amidases from Pseudomonas SY-77, or a functional part, derivative or analogue thereof. The invention also relates to a method for preparing 7-aminocephalosporanic acid from cephalosporin C, using a glutaryl amidase according to the invention. The invention... Agent: Trask Britt

20060292666 - Fermentation method for the preparation of testolactone by fusarium species: The present invention relates to a microbial method for the simultaneous dehydrogenation and oxidation of 4-an-drosten-3,17-dione to produce 17a-oxo-D-homo-1,4-andrustadiene-3,17-dione in high yield and high substrate concentrations, by means of filamentous Fusarium species.... Agent: Pfizer Inc

20060292667 - Method for improving solubility and folding efficiency of target proteins using rna as molecular chaperone: Disclosed is a method for improving folding efficiency and solubility of a target protein linked to a RNA-binding protein by using RNA molecule as a molecular chaperone, wherein the RNA molecule interacts with the RNA-binding protein. More particularly, the present invention discloses method for improving folding efficiency and solubility of... Agent: Lucas & Mercanti, LLP

20060292672 - Cell lines for expressing enzyme useful in the preparation of amidated products: Cell lines are provided for expressing peptidylglycine alpha-amidating monooxygenase (PAM), or one of its two catalytic domains. High levels of enzyme expression are achieved while utilizing a non-animal source, low protein tissue culture medium. A robust two-step downstream purification results in high enzyme purity. Resulting PAM, or its PHM catalytic... Agent: Ostrolenk Faber Gerb & Soffen

20060292669 - Mammalian prickle gene: The present invention provides the mPrickle gene which encodes a protein present in mammalian PSD fractions. The mPrickle protein is localized in synapses, and binds to the scaffold protein PSD-95. Precipitation of endogenous mPrickle using an anti-mPrickle antibody results in the coprecipitation of NMDA receptors, and thus, mPrickle can be... Agent: Townsend And Townsend And Crew, LLP

20060292671 - Mannitol induced promoter systems in bacterial host cells: The present invention provides methods for producing recombinant peptides in a bacterial host utilizing a mannitol, arabitol, glucitol, or glycerol-inducible promoter, wherein the host bacterial cell that produces the peptide has been rendered incapable of degrading or metabolizing mannitol, arabitol, or glucitol, or derivatives or analogues thereof. The present invention... Agent: King & Spalding LLP

20060292670 - Nell peptide expression systems and bone formation activity of nell peptide: The invention generally relates to a bone growth factor, and more particularly to compositions including NELL1, articles of manufacture including NELL1 and methods of using NELL1 to induce bone formation. This invention also provides methods for the expression and purification of NELL1 and NELL2 peptides.... Agent: Squire, Sanders & Dempsey L.L.P.

20060292668 - Nuclear factor of activated t cell receptor: Novel nuclear factor of activated T cells (“NFAT”) activating receptor useful for producing agonist and antagonist antibodies that regulate the cellular production and expression of cytokines and cellular receptors. The receptor is a 270 amino acid type I transmembrane protein with a calculated molecular mass of about 30 kD. The... Agent: Cheryl Liljestrand Tanox Inc

20060292673 - 2-o sulfatase compositions and methods of degradation therewith: The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present... Agent: Wolf Greenfield & Sacks, PC

20060292674 - Corynebacterium glutamicum genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins: Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further... Agent: Lahive & Cockfield, LLP

20060292675 - Process for producing fatty acids: A process for producing fatty acids, which comprises supplying an oil phase substrate and a water phase substrate to an enzyme column packed with an immobilized enzyme, concurrently flowing them in the same direction, and hydrolyzing a fat and/or oil, wherein the oil phase substrate and the water phase substrate... Agent: C. Irvin Mcclelland Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20060292676 - Method for the producing vanillic acid and vanillin from waste residue of rice bran oil by fermentation and biotransformation: A method for the production of vanillic acid and vanillin from waste residue (niger) of rice bran oil by microbial fermentation and biotransformation is provided. The method of the present invention comprises the steps of hydrolization of ferulic acid esters in waste residue of rice bran oil to ferulic acid... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20060292677 - Use of corn with low gelatinization temperature for production of fermentation-based products: The present invention provides a method of producing fermentation-based products, such as ethanol and citric acid, from corn in which the starch has a low gelatinization temperature, particularly a waxy maize plant which is homozygous or heterozygous for the recessive sugary-2 allele.... Agent: National Starch And Chemical Company

20060292678 - Gluconobacter oxydans 2-ketoreductase enzyme and applications thereof: This invention relates to an novel Gluconobacter oxydans 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding G. oxydans 2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated G. oxydans... Agent: Louis J. Wille Bristol-myers Squibb Company

20060292679 - Beer containing monascus-derived pigments: Beers and processes for the production thereof are provided in accordance with the present invention, in which Monascus—derived pigments are employed as natural (i.e. non-synthetic) colorants.... Agent: James W. Kerr Inbev S.a.

20060292680 - Affinity membrane for capture of a target biomolecule and formation thereof by site-directed immobilization of a capture biomolecule: Compositions and methods are taught for directing the orientation of an immobilized capture biomolecule on a hydrophobic membrane. The method comprises layering at least one tie layer on a hydrophobic membrane, adding an amine functional layer on top of at least one tie layer; and attaching an alignment biomolecule to... Agent: Jonathan E. Grant

20060292681 - Method for designing modulators of flexible multi-domain protein kinases: The present invention describes novel methods of designing protein kinase modulators, particularly modulators that interact at the interface between two protein kinase domains. In some embodiments, the methods comprise determining the position of at least one site between the first domain and the second domain, wherein the modulator binds to... Agent: Wilmer Cutler Pickering Hale And Dorr LLP

20060292682 - Addition of transgenes into adenoviral vectors: Adenoviral vectors are provided that contain a transgene inserted in the viral genome at a novel site such that one or more of native processing, regulatory signals or heterologous transcription signals such as branch point sites, splice acceptor sites, internal ribosome entry sites, self-processing cleavage sites and/or polyA signals contribute... Agent: Dla Piper Rudnick Gray Cary US LLP Patent Group

20060292683 - Cross-beta structures on microbial organisms: The present invention discloses the use of a protease inhibitor in the preparation of a medicament for the treatment of microbial infections. The invention further discloses the use of a compound binding to a cross-β structure or an antibody specific for a cross-β structure in the preparation of a medicament... Agent: Trask Britt

20060292684 - Method and system for treating oxidized contaminant-containing matrix: A new and useful way of treating oxidized-contaminant-containing water, soil, rock, other geological or non-geological matrix formation (such as a landfill) is provided. A bioreactor is provided that includes elemental sulfur and a microbial population capable of oxidizing sulfur and reducing pertechnate (TcO4−), arsenate (H2AsO4−), chromate (CrO42−), bromate (BrO3−), chlorite... Agent: Lawrence R. Oremland, P.C.

20060292685 - Method of sustained microbial production of hydrogen gas in a bioreactor utilizing an equalization tank: The present invention provides a method of hydrogen production from microorganisms, wherein a bioreactor provides an environment conducive to the production of hydrogen from hydrogen producing microorganisms and restrictive to the production of methane from methanogens. The method further includes an equalization tank that provides improved control of flow rates,... Agent: Eckert Seamans Cherin & Mellott

20060292686 - Analyte recovering device, and analyte recovering method: An analyte recovering device which supplies an analyte solution containing an analyte to a flow path including a substantially flat face on which a ligand is attached, for binding the ligand and the analyte in the analyte solution with each other, and recovering the bound analyte is provided. The device... Agent: Sughrue Mion, PLLC

20060292687 - Methods for modulating floral organ identity, modulating floral organ number, increasing of meristem size, and delaying flowering time: This invention is directed to plant genetic engineering. In particular, it relates to, for example, modulating seed (and in particular endosperm, embryo and seed coat) development, flowering time, chromosomal DNA methylation and modulating transcription in plants.... Agent: Townsend And Townsend And Crew, LLP

20060292689 - Car receptor as a mediator of migratory cell chemotaxis and/or chemokinesis: This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of CaR receptor expressing cells of hematopoietic, neural, epithelial, endothelial, or mesenchymal origin, in a specific site in a subject. The foregoing... Agent: Edwards & Angell, LLP

20060292690 - Method of making cell growth surface: The present invention discloses a three-dimensional porous growth surface made from polysaccharide material, especially the alginic acid, to enhance cell growth surface, promote cell adherence, immobilization and propagation, maintain surface structure integrity, enable programmable degradation, and thus increase cellular production. The present invention teaches several methods: a method to enhance... Agent: Birch Stewart Kolasch & Birch

20060292692 - Potentially regenerative cells and functional tissue-organs in vitro: Compositions and methods are provided for culturing in vitro potentially regenerative cells (PRCs) from which functional tissue-organs are regenerated. In one aspect of the invention, a tissue culture medium is provided which comprises at least 50% of water and a sterol compound that is dissolved in a fatty acid-containing oil... Agent: Wilson Sonsini Goodrich & Rosati

20060292691 - Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina): The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20060292688 - System and sequential culture media for in vitro fertilization: Instead of immersing human reproductive cells in a single culture medium throughout the various procedures used in IVF, a process is provided by which the reproductive cells may be moved through a sequence of distinct culture media as the various IVF procedures are carried out. In one implementation, the culture... Agent: Foley & Lardner LLP

20060292693 - Monoclonal antibody with the capability of neutralizing enterovirus type 71 infection: The present invention provides a monoclonal antibody capable of neutralizing EV71 infection.... Agent: Cohen, Pontani, Lieberman & Pavane

20060292695 - Methods and kits for drug screening and toxicity testing using promoter-reporter cells derived from embryonic stem cells: This invention provides a system for rapid determination of pharmacologic effects on target tissue types in cell populations cultured in vitro. The cells contain a promoter-reporter construct that reflects a toxicologic or metabolic change caused by the agent being screened. The promoter is taken from a gene known to be... Agent: Geron Corporation

20060292694 - Reporter hepatocytes and other cells for drug screening and toxicity testing: This invention provides a system for rapid determination of pharmacologic effects on target tissue types in cell populations cultured in vitro. The cells contain a promoter-reporter construct that reflects a toxicologic or metabolic change caused by the agent being screened. The promoter is taken from a gene known to be... Agent: Geron Corporation

20060286544 - Establishment of a human embryonic stem cell line using mammalian cells: Purified preparations of human embryonic stem cells with certain population-specific characteristics are disclosed. This preparation is characterized by the positive expression of the following pluripotent cell surface markers: SSEA-1 (−); SSEA-4 (+); TRA-1-60 (+); TRA-1-81 (+); alkaline phosphatase (+), as well as a set of ES cell markers including Oct-4,... Agent: Vinson & Elkins, L.L.P.

20060286552 - Direct quantification of gene expression using capillary electrophoresis with laser-induced fluorescence: Provided is a method for direct quantification of gene expression using capillary electrophoresis with laser-induced fluorescence to measure RNA in a sample. Also provided is a method of diagnosing a disease in a subject, wherein the disease is caused by increased or decreased expression of a causative gene.... Agent: Needle & Rosenberg, P.C.

20060286546 - Method and kit for the quantitative and/or qualitative detection of components in a sample: A method and kit for quantitatively and/or qualitatively detecting one or more components in samples, including the use of metal-particle labelled reagents and an antibody conjugate are disclosed. The components are capable of binding to a probe. A kit and method for staining components in cell and tissue sections, based... Agent: Knobbe Martens Olson & Bear LLP

20060286548 - Method of making recombinant human antibodies for use in biosensor technology: According to the current invention and apparatus and methods are provided for the production of modified antibodies and calins for use in biosensor applications.... Agent: Gtc Biotherapeutics, Inc, C/o Wolf, Greenfield & Sacks, P.C.

20060286549 - Microfluidic system for identifying or sizing individual particles passing through a channel: An apparatus for characterizing and identifying individual particles, including: an input reservoir; at least one output reservoir; a channel connecting the input reservoir to the at least one output reservoir, wherein the channel is functionalized with at least one molecule selected to interact with a marker on a surface of... Agent: Gordon & Rees LLP

20060286551 - Rt-pcr detection for differential diagnosis of field isolates or lapinized vaccine strain of classical swine fever virus (csfv) in samples: The present invention provides a rapid RT-PCR detection method and a diagnostic kit for differentiating field isolates of classical swine fever virus (CSFV) from lapinized CSF vaccine viruses in samples. In order to detecting different genotypes of CSF virus, this invention uses a pair (or pairs) of CSF virus specific... Agent: Pai Patent & Trademark Law Firm

20060286550 - Substrates for isolating, reacting and microscopically analyzing materials: An immobilizing device for biological material comprises a rigid support (12) carrying a substrate layer (20, 20′) of polymer having biological immobilizing properties, e.g. for amino and nucleic acids. Substantially solid ultra-thin substrate layers (20′) having a thickness less than about 5 micron, preferably between about 0.1 and 0.5 micron,... Agent: Fish & Richardson PC

20060286547 - Time-of-addition assay for identifying anti-viral compounds: The present invention relates to a multi-well assay for identifying a compound inhibiting the replication cycle of a micro-organism, for example, HIV, and to an apparatus for carrying out an assay according to the present invention. The invention further relates to compounds identifiable with an assay according to the invention... Agent: Philip S. Johnson Johnson & Johnson

20060286545 - Viral vectors with improved properties: Methods to improve the tropism or other features of a virus is disclosed. Such methods can be used to prepare, e.g., DNA or plasmid libraries of variants of a gene encoding a viral capsid or envelope restriction site, libraries of viral clones with such variant genes with a randon-dy inserted... Agent: Darby & Darby P.C.

20060286563 - Analytical method and device utilizing magnetic materials: The present invention relates to an analytical method and device utilizing magnetic materials and acoustics sensor. The invention employs a magnetic material modified with specific recognizable molecules to capture a substance in a sample and provides an external magnetic field to draw the magnetic material to an sensing region of... Agent: Bacon & Thomas, PLLC

20060286597 - Aortic carboxypeptidase-like polypeptide: The invention features a aortic carboxypeptidase-like polypeptide (ACLP), DNA encoding ACLP, and methods of detecting genetic alterations associated with abdominal wall defects.... Agent: Mintz, Levin, Cohn, Ferris, Glovsky And Popeo, P.C.

20060286592 - Candida kefyr cytosine deaminase: A new cytosine deaminase gene and protein from Candida kefyr are provided. This protein has increased ability to convert the 5-fluorocytosine prodrug to its toxic form when compared against the E. coli enzyme.... Agent: Jenkens & Gilchrist

20060286590 - Cis-regulatory modules: A process for identifying a cis-regulatory module including aligning a target sequence with at least one sequence from a moderately distant species; determining a non-coding region of the target sequence, wherein the non-coding region comprises at least one of a high level of conservation and a suppression of indels; and... Agent: Min, Hsieh & Hack LLP

20060286557 - Combined lysis and pcr buffer: The present invention provides compositions, methods, and kits for lysing cells, storing nucleic acids, amplifying nucleic, and analyzing nucleic acids. Among other things, the compositions, methods, and kits are suitable for one-step lysis and amplification of nucleic acid sequences of interest. In general, the compositions comprise TCEP and a non-ionic... Agent: LatimerIPLaw, LLP

20060286574 - Compositions and methods for enhancing drug sensitivity and treating drug resistant infections and diseases: The present invention provides compositions useful in treating drug-resistant microorganisms and cells, as well as related methods of identifying and using such compositions. In addition, the present invention includes compositions useful in enhancing the sensitivity of both drug-resistant and drug-sensitive microorganisms and cells to microbicidal and cytotoxic agents, including antibiotics... Agent: Quine Intellectual Property Law Group, P.C.

20060286584 - Compositions and methods for the regulation of cell proliferation and apoptosis: The present invention includes compositions and methods for the detection, characterization, diagnosis and kits related to the modification of transcriptional factors of the YAP signaling pathway and their correlation with oncogenesis.... Agent: Chalker Flores, LLP

20060286566 - Detecting apparent mutations in nucleic acid sequences: A target nucleic acid sequence information obtained from a biological sample can be compared against a collection of reference nucleic acid sequences. The target nucleic acid sequence is aligned or matched against the reference sequences, wherein some of the target sequences have one or more polymorphisms. Different collections of reference... Agent: Edwards & Angell, LLP

20060286578 - Detection of 5t4 rna in plasma and serum: This invention provides methods for detecting the presence of malignant or premalignant cells, or trophoblastic cells in a human wherein the malignant, premalignant or trophoblastic cells express 5T4. The methods of the invention detect 5T4 RNA in blood, blood plasma, serum, and other bodily fluids. The inventive methods are useful... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20060286594 - Detection of antidepressant induced mania: Methods and kits for assessing the susceptibility of a patient to antidepressant-induced mania are described. The method involves testing a sample from a patient for the presence of the s variant of the 5HTTLPR polymorphism in the 5HTT gene. The presence of this s variant indicates that the patient is... Agent: Bereskin And Parr

20060286554 - Fluid container for electrohydrodynamic spray device and method of using same: A fluid container (6) for use with an electrohydrodynamic spray device (1) and method of using the device (1) are provided. The container (6) comprises at least one reservoir configured for holding a sprayable liquid, at least one interface (23) in fluid communication with the reservoir, at least one manifold... Agent: Dennis Kilfoil

20060286588 - Genetic variants in the tcf7l2 gene as diagnostic markers for risk of type 2 diabetes mellitus: Polymorphisms in the gene TCF7L2 are shown by association analysis to be a susceptibility gene for type II diabetes. Methods of diagnosis of susceptibility to diabetes, of decreased susceptibility to diabetes and protection against diabetes, are described, as are methods of treatment for type II diabetes.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20060286581 - Heteroconfigurational polynucleotides and methods of use: Methods, compositions and kits are disclosed that utilize heteroconfigurational polynucleotide comprising a D-form polynucleotide sequence portion and an L-form polynucleotide sequence portion that is covalently linked to the D-form polynucleotide sequence portion.... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20060286568 - Identification of a gene associated with spinocerebellar ataxia type 5 and methods of use: The present invention provides methods that include analyzing an SCA5 polynucleotide, and determining whether the SCA5 polynucleotide includes a mutation. The methods may be used to identify a subject that is at risk or not at risk for developing spinocerebellar ataxia type 5. The present invention also provides isolated polynucleotides... Agent: Mueting, Raasch & Gebhardt, P.A.

20060286598 - Isolated cel ii endonuclease: The present invention relates to the isolation and characterization of CEL I and CEL II endonuclease proteins. Methods and kits for identifying mismatches in double-stranded DNA are also provided.... Agent: Licata & Tyrrell P.C.

20060286556 - Lymphoid chemokines in the diagnosis, monitoring and treatment of inflammatory disease: Experimental autoimmune encephalomyelitis (EAE) is a Th1-mediated autoimmune disease of the central nervous system that is widely used as an animal model of multiple sclerosis (MS). In this study it was demonstrate that CXCL13, a chemokine involved in the development of secondary lymphoid tissues, is expressed in CD11c+ myeloid cells... Agent: Fish & Richardson P.C.

20060286575 - Mcl-1 quadruplex nucleic acids and uses thereof: A biologically significant quadruplex structure in the MCL-1 regulatory region has been discovered. Certain mutations in quadruplex forming nucleotide sequences alter quadruplex structure and are associated with cancer and perhaps other diseases. Thus, provided herein are MCL-1 quadruplex nucleic acid acids, cancer diagnostics and prognostics, methods for using the cancer... Agent: Morrison & Foerster LLP

20060286596 - Method and apparatus for separating and purifying biopolymers: The present invention separates and purifies a negatively charged target biopolymer from among biological samples without involving fluid movements. In other words, a first solution containing said biological samples and a second solution for preserving a separated and purified biopolymer are partitioned by a gel, thereby allowing said target biopolymer... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20060286573 - Method for determining nucleotide sequence of nucleic acid molecule by utilizing scanning probe microscope: A nucleotide sequence of a single-stranded nucleic acid molecule immobilized on a substrate is determined with an SPM by analyzing a shape of bases constituting the single-stranded nucleic acid molecule by scanning over a nucleic acid chain of the single-stranded nucleic acid molecule immobilized on the substrate with a probe... Agent: Fitzpatrick Cella Harper & Scinto

20060286553 - Method for forming self-assembly substance using oligonucleotide synthesized by gene amplification reaction, self-assembly substance and method for detecting gene: There is provided a method for forming a self-assembly substance u