Chemistry: molecular biology and microbiology inventions 10/06

20060240399 - Long-term shelf preservation of cells and multicellular specimens by vitrification: The method of preservation by vitrification, described in the present application, provides for storage of samples at higher temperatures than in conventional methods and can be applied to cells, multicellular tissues, organs and organisms. The method of the present invention includes preparing a solution of vitrification non-permeating co-solutes (amino acids,...

20060240401 - Handheld raman body fluid analyzer: Methods and apparatus for in vitro detection of an analyte in a body fluid sample using low resolution Raman spectroscopy are disclosed. The body fluid analyzer includes a disposable strip for receiving a sample of body fluid on a target region, the target region including gold sol-gel to provide surface...

20060240400 - High-density cell array board, process for producing the same and method of using the same: Culture substrates, cell arrays, automatic chemical dispensers and assay systems necessary for conveniently assaying multiple chemicals such as drugs and toxic agents are provided. Herein used is a substrate for a high-density cell array characterized in that it has a surface comprising an ordered array of discrete microdomains coated with...

20060240402 - Marine invertebrate gametes and embryos as an assay system for therapeutic screening: The invention provides methods of using of marine invertebrate gametes and preparations thereof for drug discovery and therapeutic screening....

20060240404 - Methods of isolating genes encoding proteins of specific function and of screening for pharmaceutically active agents: A method of isolating polynucleotides encoding polypeptides affecting an organization of a subcellular organelle or structure of interest is provided. The method comprises: (a) expressing within a plurality of cells an expression library including a plurality of expression constructs each encoding a polypeptide of interest; (b) highlighting the subcellular organelle...

20060240403 - Tape magazine for a hand-held device: The present invention concerns a tape magazine especially for a hand-held device for analysing a body fluid with a test tape that can be unwound from a storage unit and wound onto a waste unit where the waste unit can be driven in order to wind forward the test tape....

20060240412 - Compositions for use in identification of adenoviruses: The present invention provides compositions, kits and methods for rapid identification and quantification of adenoviruses by molecular mass and base composition analysis....

20060240407 - Detection and identification of enteroviruses: Disclosed herein are methods of using enterovirus-specific primers for the detection and identification of enterovirus infection. Also provided herein are isolated nucleic acid molecules and kits useful for detection and diagnostic testing of enterovirus infection in a subject....

20060240414 - Genetically engineered glutaminase and its use in antiviral and anticancer therapy: DNA encoding a therapeutically suitable glutaminase has been molecularly cloned. This allows one to obtain a polypeptide which is a therapeutically suitable glutaminase free of contaminating endotoxin. It has been found that this polypeptide is a potent anti-viral agent and when coupled to an anti-tumor monoclonal antibody is a potent...

20060240413 - Medical test probe for cell sample collection: A device and method are disclosed for collecting biological samples. One embodiment includes a device for collecting biological samples comprising a probe having a cell collector located on a distal end, the probe having a plurality of distinct raised protrusions....

20060240405 - Method for assaying replication of hbv and testing ... drugs: A method for measuring the replication capacity of HBV, e.g. HBV present in a biological sample, possibly in the presence of a pharmaceutical product, in particular an antiviral agent, the method comprising: (a) possibly extracting nucleic acids contained in the biological sample; (b) PCR amplifying HBV nucleic acids using at...

20060240409 - Method for extraction and identification of nucleic acids: The invention provides a method for extracting nucleic acids from a sample. The sample contains cells, viruses, or both cells and viruses. The method include adding a lysing solution containing a detergent to the sample to lyse the cells or viruses to form a lysate, adding alcohol to the lysate...

20060240406 - Method for the detection of proteolytic enzymes: The present invention provides an improved protease assay in which the proteases are detected on basis of their capability to cleave a modified pro-caspase which will yield an activated caspase which can then further be detected. Also part of the invention are the modified pro-caspases and kits comprising said modified...

20060240408 - Method of purifying nucleic acid using silver nanoparticles: Provided is a method of purifying a target substance using silver nanoparticles. The method includes: mixing a sample containing molecules having a thiol group with the silver nanoparticles to obtain a complex of the molecules having the thiol group with the silver nanoparticles; and isolating and removing the complex from...

20060240411 - Multiplex microparticle system: Arrays of microparticle populations, each population labeled with a single fluorescent dye, are provided for use in multiplex assays. The populations form a virtual multidimensional array wherein each microparticle is identified by fluorescence intensity in two different fluorescence detection channels. The arrays are useful in a variety of assays, including...

20060240410 - Retroviral protease inhibitor combinations: The present invention is directed to a method for the treatment of mammalian retrovirus infections, such as HIV, using combinations of retroviral protease inhibitors which are effective in preventing the replication of the retroviruses in vitro or in vivo. This invention, in particular, relates to protease inhibitor compounds used in...

20060240415 - Screening compound libraries using an optical fiber array device capable of simultaneously performing multiple functional assays: Disclosed is a method of screening Compounds wherein target cells are coated onto a population of microbeads, and wherein each microbead is coated with several cells of the same cellular type and has an assay and an assay reporter associated with it. Each of the cell-coated microbeads are positioned in...

20060240417 - Agent controlling the apoptosis induction by p73: Elucidation of the interaction between p73 and ΔNp73 on the genetic and protein level, regulators for p73 or p53 apoptosis-inducing activity, a method of accelerating apoptosis of tumor cells by utilizing the regulators, p53 and p73 transactivation regulators comprising the p73 gene and ΔNp73 gene, nucleic acid pharmaceutical compositions comprising...

20060240467 - Analyte sampling element, analyte treatment device and analyte treatment method: In order to simplify the pretreatment such as collection of an analyte, treatment of the analyte, introduction of the analyte into a measurement system (reaction system) and dilution of the analyte and to improve operability in examinations using large-sized automatic analyzers and POCT devices, the present invention provides an analyte...

20060240418 - Canine gene microarrays: The present invention is based on the identification of novel canine nucleic acid sequences and the construction of canine microarrays containing a significant portion of the canine genome. The microarrays specifically hybridize to canine nucleic acid samples and may be used in drug screening and toxicity assays....

20060240422 - Caspase 10 as target for monitoring and treatment of diseases: The present invention relates to a method of monitoring and/or modulating disease-associated activatory procceses which are mediated by caspase-10 or caspase-10 isoforms....

20060240448 - Cell concentration and lysate clearance using paramagnetic particles: Methods are disclosed for using paramagnetic particles to concentrate or harvest cells. Methods are also disclosed for clearing a solution of disrupted biological material, such as a lysate of cells or a homogenate of mammalian tissue. Methods are also disclosed for using paramagnetic particles to isolate target nucleic acids, such...

20060240459 - Clckb mutation as a diagnostic and therapeutical target: The present invention relates to a method for diagnosing hypertension, and/or allergy, and/or hair loss, and/or liabilty for infection, of a human being, or a predisposition therefor; to a nucleic acid molecule coding for a human ClCKb protein comprising a genetic alteration at amino acid position 481 compared to the...

20060240453 - Clinically intelligent diagnostic devices and methods: The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of...

20060240465 - Cng2b: a novel human cyclic nucleotide-gated ion channel: The invention provides isolated nucleic acid and amino acid sequences of CNG2B, antibodies to CNG2B, methods of detecting CNG2B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG2B. The invention further provides, in a computer system, a method of screening for mutations of human...

20060240451 - Compositions and methods employing 5' phosphate-dependent nucleic acid exonucleases: The present invention relates to compositions and methods employing 5′-phosphate-dependent nucleic acid exonucleases. In particular, the present invention provides kits and methods employing 5′-phosphate-dependent nucleic acid exonucleases for selective enrichment, isolation and amplification of a particular set of desired nucleic acid molecules from samples that also contain undesired nucleic acid...

20060240444 - Detection methods: A method of detecting one or multiple target molecules in a test sample....

20060240436 - Diagnostics and therapeutics for diseases associated with complement component 5a receptor (c5ar): The invention provides a human C5AR which is associated with the cardiovascular disorders, inflammatory diseases, gastrointestinal and liver diseases, cancer disorders, hematological disorders, respiratory diseases and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, inflammatory diseases, gastrointestinal...

20060240433 - Facls as modifiers of the rb pathway and methods of use: Human FACL genes are identified as modulators of the RB pathway, and thus are therapeutic targets for disorders associated with defective RB function. Methods for identifying modulators of RB, comprising screening for agents that modulate the activity of FACL are provided....

20060240458 - Flexible culture medium bag containing nutrient concentrate: Disclosed is a culture medium container such as a bag comprising a main compartment and a locus of containment that contains a nutrient concentrate until it is released at the time of use. The locus of containment may comprise separated compartments defined by frangible seals or seals comprising a water-reactive...

20060240452 - Flourecent quinacridone derivatives: The present invention relates to methods and compositions utilizing fluorescent quinacridone derivatives. In particular, the present invention relates to the use of fluorescent quinacridone derivatives for the labeling and detection of riucleic acids. The present invention thus provides improved compositions and methods for labeling biological molecules useful in the detection...

20060240470 - Gene causative of rothmund-thomson syndrome and gene product: The RecQ4 helicase gene, belonging to the RecQ helicase gene family, is revealed herein to be the causative gene of Rothmund-Thomson syndrome. The present inventors found out that it is possible to diagnose Rothmund-Thomson syndrome by detecting mutation of this gene. Further, they uncovered that it is possible to treat...

20060240426 - Gene expression in biological conditions: The present invention relates to a method of predicting the prognosis of a biological condition in animal tissue, wherein the expression of genes is examined and correlated to standards. The invention further relates to the treatment of the biological condition and. an assay for predicting the prognosis. In particular, the...

20060240441 - Gene expression profiles and methods of use: The present invention relates to gene expression profiles for lung cancer, microarrays comprising nucleic acid sequences representing gene expression profiles, and methods of using expression profiles and microarrays. The invention also provides methods and compositions for diagnostic assays for detecting cancer and therapeutic methods and compositions for treating cancer. The...

20060240425 - Genes and polypeptides relating to myeloid leukemia: The present application provides novel human genes RHBDF1 whose expression is markedly elevated in CML and AML compared to normal peripheral blood cell, and lung adenocarcinoma compared to normal lung cell. The genes and polypeptides encoded by the genes can be used, for example, in the diagnosis of a cell...

20060240450 - Genetic analysis for stratification of cancer risk: The present invention provides new methods for the assessment of cancer risk in the general population. These methods utilize particular alleles of two or more genes, in combination, to identify individuals with increased or decreased risk of cancer. Exemplified is risk assessment for breast cancer in women. In addition, personal...

20060240421 - Genetic polymorphisms sensitively predicting adverse drug reactions (adr) and drug efficacy: The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad...

20060240471 - Genetic test for the identification of carriers of complex vertebral malformations in cattle: Genetic markets for identifying bovine carriers of complex vertebral malformation (CVM) disease gene are described. The genetic markers, including the microsatellite markers, BM4129, INRAA003, BMS2790, ILSTS029, INRA123, BM220, HUJ246, BMS862, BMS937, BL1048, BMS2095 and BMS1266 and the bovine SLC35A3 gene, are located on bovine chromosome BTA3. The G/T polymorphism at...

20060240423 - Isolation and cloning of dna from uncultivated organisms: The present invention relates to a device for the isolation and/or purification of nucleic acid molecules suitable to bind and/or inactivate inhibitors of the activity of reagents or enzymes used for DNA manipulation and to separate a plurality of nucleic acid molecules with respect to their size. Moreover, the invention...

20060240432 - Lrp4/corin dopamine-producing neuron proliferation precursor cell marker: In neuron transplantation therapy, in terms of safety, it is preferable to use a cell population consisting only of a desired type of cells, and to use postmitotic neurons in consideration to avoid the risk of tumorigenesis. Moreover, greater therapeutic effects would be expected through the use of earlier progenitor...

20060240463 - Markers associated with the therapeutic efficacy of glatiramer acetate: The present invention is directed to methods and kits based, at least in part, on the identification of allele-specific responsiveness or non-responsiveness to glatiramer acetate for the treatment of immune disorders, such as relapsing-remitting multiple sclerosis. The allele-specific responsiveness or non-responsiveness is based on polymorphisms in the following genes, CTSS,...

20060240460 - Method for detecting methylated cpg islands: The present invention provides new and improved assay for detection of genomic methylated CpG islands. This new method is termed the methylated-CpG island recovery assay (MIRA). In accordance with one embodiment, MIRA comprises the steps of: (a) incubating genomic DNA fragments with a methylated CpG island binding protein in the...

20060240469 - Method for generating transcriptionally active dna fragments: A method for producing transcriptionally active DNA molecules, comprising (PCR) amplification of said DNA molecule in the presence of a first DNA fragment (F1), second DNA fragment (F2), first primer (P1), a second primer (P2), a third primer (P3), and a fourth primer (P4) wherein: F1 comprises a promoter sequence;...

20060240430 - Method for hybridisation of immobilized genomic dna: The present invention is directed to a novel method of efficiently hybridising probes onto immobilized genomic DNA and/or RNA comprising the steps of (a) providing intact genomic DNA and denaturing said intact genomic DNA; (b) immobilizing said denatured intact genomic DNA onto a matrix; said matrix comprising pore sizes within...

20060240427 - Method for the detection of pathogenic gram positive bacteria from the genera staphylococcus, enterococcus and streptococcus: The present invention is directed to a method for identification of a Gram positive pathogenic bacterium comprising an amplification step with at least a first set of amplification primers capable of amplifying a preselected nucleic acid sequence region from a first predetermined sub-group of pathogenic Gram positive bacteria, and a...

20060240419 - Method of detecting gene polymorphism: A method for detecting a genetic polymorphism(s), comprising creating oligonucleotide probes and/or oligonucleotide primers so that the probes and/or primers contain a polymorphic site(s) present in a gene encoding a receptor or a sequence complementary thereto or so that the polymorphic site(s) is/are contained in the amplified fragment when at...

20060240428 - Method of identifying disease-sensitivity gene and program and system to be used therefor: The object of this invention is to provide a method for efficiently identifying a disease susceptibility gene and, in particular, a disease susceptibility gene of a disease such as a multifactorial disease where a large number of genes are involved. This invention relates to a method for identifying a disease...

20060240468 - Method of reverse transcription: The present invention relates to reverse transcription of RNA, and in particular to reverse transcription by thermostable DNA polymerases. Thermoactinomyces vulgaris and Bacillus stearothermophilus possess reverse transcriptase activity in the presence of magnesium or manganese ions. Methods, compositions, and kits for reverse transcription and RT-PCR are also provided....

20060240429 - Method of screening compound inhibiting enzymatic activity of gwt1 gene product: The present invention enables screening for compounds that inhibit the transport of GPI-anchored proteins to fungal cell walls, using a simple assay for transacylation to GlcN-PI using membrane fraction expressing GWT1 protein. New antifungal agents can be created that inhibit the synthesis of fungal cell walls and also inhibit adhesion...

20060240449 - Methods and compositions for preparation of biological samples: Methods and compositions for preparation of biological samples are disclosed. The methods include a prelysis step and a lysis step to make the cellular DNA available for further processing, amplification or analysis. The prelysis step includes the addition of a prelysis reagent to the cells. The prelysis reagent may include...

20060240440 - Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin k epoxide reductase gene and warfarin dosage: The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide polymorphism in the VKOR gene, wherein the single nucleotide polymorphism is correlated with increased or decreased sensitivity to warfarin, thereby identifying...

20060240442 - Methods and oligonucleotides for the detection of salmonella sp., e coli 0157:h7, and listeria monocytogenes: A method for detecting a Salmonella species, E. coli 0157:H7, or Listeria monocytogenes is disclosed. The method involves amplifying a genomic nucleotide sequence of a corresponding species and detecting the amplification product. Various primers and probes that can be used in the method are also disclosed. In one embodiment, the...

20060240462 - Methods for amplification and detection of nucleic acids: Provided herein are methods for the combined amplification and detection of one or a plurality of target nucleic acid molecules. The methods encompass the use of an antisense strand of a catalytic nucleic acid in a primer for amplification such that an amplicon produced thereby includes an active catalytic nucleic...

20060240457 - Methods for characterizing agonists and partial agonists of target molecules: In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma...

20060240461 - Methods for detecting nemaline myopathy: The present invention provides identification of a mutation related to the nebulin gene (NEB), which can cause nemaline myopathy (NM). The present invention also provides a method for detecting such mutation in a human cell or individual, such as an NM-derived cell or an individual suffering from NM. The present...

20060240443 - Microarray-based single nucleotide polymorphism, sequencing, and gene expression assay method: There is disclosed a microarray-based single nucleotide polymorphism, sequencing, and gene expression assay method. Specifically, there is disclosed a method using a microarray device wherein a plurality of hybridized structures is formed by contacting the microarray under a hybridizing condition to a hybridizing solution comprising a plurality of tagged targets...

20060240454 - Mmethod of analyzing breast cancer susceptibility and resistance: A method of analyzing breast cancer susceptibility or resistance, comprising the steps of obtaining a DNA sample from a patient, genotyping the sample for the presence of the minor allele of single nucleotide polymorphisms rs6476643 or rs2182317, and correlating the identity of the allele with risk assessment data is disclosed....

20060240439 - Modified polymerases for improved incorporation of nucleotide analogues: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3′ position of the sugar moiety that are larger in size than the naturally occurring 3′ hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly...

20060240416 - Multianalyte molecular analysis using application-specific random particle arrays: The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles and encoded particles. The sub-libraries are functionalized on demand are useful in the formation of arrays. The present invention is especially useful...

20060240445 - Multiplex snp typing by bioluminometric assay coupled with terminator incorporation: The present invention provides a method for analyzing a nucleotide sequence comprising the steps of: carrying out complementary strand synthesis by adding at least one of four kinds of ddNTP corresponding to nucleotides A, G, T, and C, or derivatives thereof to a reaction vessel containing a nucleic acid sample...

20060240456 - Nanosized biological container and manufacture thereof: Nanosized biological containers that are “ghosts” of viruses for which capsids are independent of their endogenous viral nucleic acid cores, provide nano-particles of uniform size, and known numbers of sites for attachments of ligands. These containers can be filled with a fluorescent, magnetic, x-ray absorbent, nucleotide components or a radioactive...

20060240464 - Novel 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552, and 65577 molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules,...

20060240446 - Novel human cytomegalovirus dna sequences: Provided are novel Toledo and Towne human cytomegalovirus DNA sequences (HCMV) and proteins encoded thereby. The sequences are useful in methods and compositions for detecting HCMV infections and in immunogenic compositions for Preventing HCMV infections....

20060240420 - Nucleic acid amplification method: A method for increasing the number of polynucleotides containing sequences corresponding to a mRNA species present in a sample, comprises the steps of: (i) reverse transcription of the RNA species using a heeled 5′-amplification primer (FAP-RAND) and a heeled 3′-amplification primer (TAP-RT), wherein each primer sequence is unique, and either...

20060240447 - Oligonucleotide sequences for the detection of ricin gene and toxin: Novel oligonucleotides useful as primers and probes in the detection and identification of ricin toxin gene and gene product are provided. A method and kit for detecting and identifying a nucleic acid from Ricinus communes are also provided....

20060240431 - Oligonucletide guided analysis of gene expression: The present invention relate to methods and compositions for simultaneously analyzing multiple different polynucleotides of a nucleic acid sample. The subject methods and compositions may also be applied to analyze or identify single polynucleotide; however, the subject methods and compositions are particularly useful for analyzing large diverse populations of polynucleotides....

20060240455 - Oxazine derivatives: Oxazine derivatives with which a broad spectrum of material to be studied can be labelled and identified by means of fluorescence techniques are described....

20060240437 - Predictors of renal disease: The invention includes diagnostic, predictive, prognostic and monitoring methods and reagents for loss of renal function, e.g., diabetic nephropathy and end stage renal disease (ESRD)....

20060240466 - Prevention of type 1 diabetes and other non-polio enterovirus diseases: Live virus vaccines comprise attenuated viruses, while other vaccines comprise killed viruses or parts thereof. It has now been found that the immune response induced by oral poliovirus vaccine (OPV), which is a live vaccine, is cross-reactive with non-polio enteroviruses. OPV is therefore useful in the prevention of non-polio enterovirus...

20060240435 - Process for producing macromolecule-identifying polymer: The methods for producing macromolecule identifying polymers according to the present invention comprise the steps of polymerizing a starting monomer in an aqueous solution in the presence of a macromolecule, a crosslinking agent, and a radical polymerization initiator to produce a polymer containing the macromolecule in its interior; and removing...

20060240424 - Regulation of human p2y15 g protein-coupled receptor: Reagents which regulate human P2Y15 G protein-coupled receptor can play a role in preventing, ameliorating, or correcting bronchoconstriction or inflammation in diseases such as allergies including but not limited to asthma. Further, such reagents is useful to treat diseases of kidney function or disease related to mast cell....

20060240434 - Standardized and optimized real-time quantitative reverse transcriptase polymerase chain reaction method for detection of mrd in leukemia: The invention relates to in a real-time quantitative reverse transcriptase polymerase chain reaction (RQ-PCR) method for minimal residual disease detection in leukemic patients through amplification of a fusion gene transcript, the improvement comprising: (i) selecting amplifiable and qualified patient samples for subsequent analysis; (ii) defining optimal conditions for performing the...

20060240438 - Surface of base material being inhibited in non-specific adsorption: A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of...

20060240478 - Biosensor: One object of the present invention is to provide a biosensor and a production method therefor, by which hydrogel that enables immobilization of a physiologically active substance can be conveniently produced using safe raw materials. The present invention provides a biosensor which comprises a substrate having a metal layer on...

20060240476 - Construct comprising recognition domain of antibody against von willebrand factor-specific cleaving enzyme: The present invention provides an epitope recognized by an antibody (hereinafter, also referred to as an anti-ADAMTS-13 antibody) against a cleaving protease (hereinafter, also referred to as ADAMTS-13) specific to von Willebrand factor (hereinafter, also referred to as vWF), and a polypeptide comprising the epitope region. The present invention also...

20060240475 - Diagnostic method for celiac sprue: Detection of toxic gluten oligopeptides refractory to digestion and antibodies and T cells responsive thereto can be used to diagnose Celiac Sprue....

20060240479 - Fluorescent label: The present invention relates to a fluorescent label characterized by containing a hydrophilic polymer having an anionic group, a polyether derivative, and a phosphor, in which the phosphor is bound to the hydrophilic polymer via the polyether derivative, and also relates to a fluorescently labeled recognition substance labeled with the...

20060240481 - Melanocortin metallopeptode combinatorial libraries and applications: Melanocortin receptor-specific peptide combinatorial libraries for forming metallopeptides and metallopeptide combinatorial libraries are provided for use in biological, pharmaceutical and related applications. The combinatorial libraries are constructed of peptides constructed from naturally occurring amino acids, stereoisomers and modifications of such amino acids, non-protein amino acids, post-translationally modified amino acids, enzymatically...

20060240477 - Method for the production of near net-shaped metallic and/or ceramic parts: The present invention relates to a peptide comprising a symmetrical dimethylated arginine, and constitute an immunologic determinant of antibodies present in sera from patients with systemic lupus erythematosus (SLE), and wherein the methylation is a prerequisite for reacting with said antibodies. The invention also relates to the use of said...

20060240482 - Methods of mhc class ii epitope mapping, detection of autoimmune t cells and antigens, and autoimmune treatment: The present invention provides of using multimeric MHC class II/peptide complexes. In one aspect, methods provided for identifying MHC class II-restricted immune epitopes of a predetermined polypeptide antigen. Methods for identifying an immunostimulatory epitope for a predetermined polypeptide antigen are provided. In a related aspect, methods for screening a therapeutic...

20060240474 - Peptides able to switch between two structural states and their use: The present invention relates to peptides that switch between 2 structural states in response to the presence or absence of a stimulus. The present invention also relates to the use of the peptides of the present invention in an assay to detect the presence or absence of a stimulus. The...

20060240472 - Pigment protein: An object of the present invention is to provide a novel chromoprotein derived from Cnidopus japonicus. The present invention provides a chromoprotein derived from Cnidopus japonicus having the following properties: (1) the absorption maximum wavelength is 610 nm, and fluorescence is not emitted; (2) the molar absorption coefficient is 66,700...

20060240473 - Saccharide libraries: Novel methodologies for producing saccharide libraries are provided as well as the libraries themselves....

20060240480 - Use of gfap for identification of intracerebral hemorrhage: The present invention relates to the use of glial fibrillary acidic protein (GFAP) as a diagnostic marker for intracerebral hemorrhage. The invention especially relates to methods for the early detection of intracerebral hemorrhage. Such early and rapid detection can be performed rapidly e.g. by a test strip format assay. GFAP...

20060240486 - Immunoprecipitation-based assay for predicting in vivo efficacy of beta-amyloid antibodies: In various aspects, the present invention provides methods and kits for predicting the therapeutic efficacy of an immunological reagent, identifying an immunological reagent having therapeutic efficacy, or both, for the treatment of an amyloidogenic disorder by comparing the amount of Aβ monomer in an Aβ preparation which binds to the...

20060240483 - Method and kit for monitoring recruitment of proteins to the intracellular domain of a receptor in intact cells: The present invention relates to an immunological method and kit for monitoring recruitment of a protein to the intracellular domain of a receptor in intact cells....

20060240485 - Method of monitoring immunotherapy: The present invention relates to a method of monitoring an immunotherapy against amyloidosis and other diseases characterized by the deposition of abnormal protein aggregates. More specifically, it relates to a method of evaluating an immunotherapy against Alzheimer's disease, based on a novel assay that is characterized by scoring immunoreactivity levels...

20060240484 - Protein for diagnosing diabetic retinopathy: The present invention relates to material for diagnosing Diabetic retinopathy. More particularly, the present invention relates to Immunoglobulin A protein for diagnosing Diabetic retinopathy, kit for diagnosing Diabetic retinopathy comprising antibody against the protein and method for diagnosing Diabetic retinopathy. The present invention can be used as diagnosing Diabetic retinopathy....

20060240490 - Methods and compositions for identifying target cell cytolytic lymphocytes in a sample: Methods and compositions for identifying target cell cytolytic lymphocytes, e.g., T-cells, such as neoplastic cell cytolytic T-cells, in a subject are provided. In practicing the subject methods, the sample is contacted with a target cell stimulator, e.g., a neoplastic cell, and a detectably labeled granule membrane protein specific binding agent....

20060240491 - Proteins involved in cytoadhesion of plasmodium falciparum ring-stage-infected erythrocytes, antibodies which bind to the proteins, and methods for detecting infection, stage of infection and vaccines for protecting against infection: The present invention provides hybridomas and antibodies which specifically react with native P. falciparum at a surface of ring stage infected erythrocytes and uses thereof....

20060240492 - Carbon nanotube based immunosensors and methods of making and using: An immunoassay device comprises a plurality of carbon nanotubes having a first end and a second end, wherein the nanotubes are aligned substantially parallel relative to one another; a substrate responsive to an electrochemical signal, the substrate being attached to the first end of at least a portion of the...

20060240493 - Cca1 as an antifungal target: The invention provides ATP(CTP): tRNA nucleotidyltransferase (CCA1) as a novel antifungal target, screening methods for CCA1 inhibitors and their use as antifungal compounds, pharmaceutical compositions containing them and their use in medicine. Specifically in the treatment of an individual susceptible to or suffering from an anti-fungal infection. In particular the...

20060240494 - Biocidal molecules, macromolecular targets and methods of production and use: A method for identifying a compound that has a biocidal effect against a selected organism involves screening from among known or unknown peptide or non-peptide molecules, a test molecule that binds selectively to a target sequence of a multi-helical lid of a heat shock protein of the organism. The binding...

20060240489 - Carbodithioate ligands for nanotechnology and biosensing applications: The present invention is directed to methods and products related to carbodithioate ligands bonded to surfaces. The invention is further directed to molecular and biomolecular sensing methods based on analyte recognition by carbodithioate ligands bonded to surfaces....

20060240488 - Detection of an immune response to gdf-8 modulating agents: This disclosure provides methods for the detection of antibodies to a GDF-8 modulating agent such as, e.g., MYO-029, in a biological sample. Methods to detect an immune response to a GDF-8 modulating agent are also included. In particular, methods to assess an immune response in animals, including humans, to a...

20060240487 - Detection of gdf-8 modulating agents: Methods to detect GDF-8 modulating agents in animals, including humans, are provided herein, including methods to detect the presence of exogenous GDF-8 modulating agent such as a GDF-8 inhibitor in a biological sample. In particular, methods to assess the presence and/or quantity of a GDF-8 modulating agent in a biological...

20060240497 - Assaying apparatus, kit, and method for lipids and associated enzymes: Lipid assay method, kit, and apparatus involving exposure of a protein, having a lipid recognition motif that interacts with a target lipid and a competing lipid, to a solution containing the competing lipid, and determining whether the target lipid is present in the solution. The target lipid has a stronger...

20060240496 - Immunogens, derivatives and immunoassay for ethyl glucuronide: Ethyl glucuronide (“EtG”) analogs can be prepared for use as immunodiagnostic reagents and in immunodiagnostic protocols. The EtG analogs can be in the form of EtG-based immunogens, and EtG-based antigens. The EtG-based immunogens can be used for preparing anti-EtG antibodies, which can be used in immunoassays. Accordingly, improved immunoassay techniques...

20060240495 - Non-invasive assessment of intra-amniotic environment: Assessing fetal health and maturity, and the integrity and health of the amnion, is effected via protein profiling of vaginal fluid, thereby to identify various abnormal conditions during pregnancy. This approach also provides a means for gauging the duration and/or magnitude of intraamniotic/fetal inflammation that occurs during pregnancy....

20060240498 - Devices and methods for detecting amniotic fluid in vaginal secretions: The present invention relates to a diagnostic method for the detection of small quantities of amniotic fluid in the vagina. More specifically, the invention relates to the detection of PAMG-1 in the vagina using anti-PAMG-1 antibodies....

20060240499 - Methods for determining phosphoryltransferase activity using adenosine 5'-triphosphate (atp)-gamma-s: This invention relates to screening assay methods that can be applied to broad members of the protein kinase gene family and are useful in the detection and evaluation of kinase inhibitors....

20060240500 - Diagnosis of kidney damage and protection against same: Various nucleic acids and proteins have been identified by differential hybridization methods as useful as markers for diagnosing kidney damage. The identified marker proteins include (I) androgen related protein, SON protein, FUSE binding Protein 1, claudin10, heat shock protein, phospho triesterase related protein, ubiquitin protein ligase Nedd-4, and Ac39/physophilin, and...

20060240501 - Defructosylation method: The present invention is directed to a defructosylation enzyme originating from a plant, a method of defructosylating a fructosylated peptide or protein through use of the enzyme, and a method of measuring a fructosylated peptide or protein....

20060240502 - Gtp cyclohydrolase ii as a target for fungicides: The present invention relates to the identification of fungal GTP cyclohydrolase II as a target for fungicides, to a method for identifying antifungal agents based on fungal GTP cyclohydrolase II, and also to the use of compounds identified as fungicides via the abovementioned method....

20060240503 - Protease detection assay: The invention provides methods and compounds for detecting protease activity in a sample solution comprising contacting the sample solution with a protease substrate labelled with an electrochemically active marker, providing conditions under which any protease which may be present in the sample may degrade the protease substrate and electrochemically determining...

20060240504 - Evaluating bacterial lethality of containerized food production: Procedures and means for evaluating effectiveness of bacterial-lethality, following batch-processed containerized food production operations and aseptic-flow food-production operations as containerized in aseptic-containers, in preparing for non-refrigerated marketing are described. The evaluations significantly expedite determining whether thermally-processed containerized food-production is safe for non-refrigerated marketing. The presence or absence of live spore-forming...

20060240505 - Identification of targets of antimicrobial compounds: A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method...

20060240507 - Cationic anti-microbial peptides and methods of use thereof: Described herein are methods of detecting a wound infection and for detecting the presence or absence of microorganisms, for example, wound pathogens in a sample, by contacting a sample with a cationic anti-microbial peptide that is degradable by an enzyme produced and/or secreted by a microorganism, and detecting degradation or...

20060240506 - Method for isolating and culturing unculturable microorganisms: The invention provides a method for isolating and culturing a previously unculturable microorganism, which comprises: (i) collecting a sample from an environmental source; (ii) counting/estimating the number of microorganisms in the sample; (iii) diluting the sample in an appropriate medium; (iv) adding a gelating agent such as to entrap one...

20060240508 - Preparation of 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof in transgenic organisms: The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in...

20060240514 - Animal product free media and processes for obtaining a botulinum toxin: Media and processes for the fermentation of Clostridium botulinum and obtaining a botulinum toxin for use in formulating botulinum toxin pharmaceutical compositions. The growth media can contain significantly reduced levels of meat or dairy by-products using non-animal based products to replace the animal-derived products. Preferably, the media used are substantially...

20060240513 - Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom: The invention provides processes for culturing cells derived from embryonic retinoblast cells immortalized by adenovirus E1 sequences, preferably PER.C6® cells, to improve product yields from such cells. Feed strategies for such cells and cultures with very high cell densities are provided, resulting in high yields of products, such as recombinant...

20060240521 - Dna sequences for regulating transcription: The invention relates to a DNA sequences for regulating transcription of a structural gene encoding a polypeptide in a eukaryotic host cell comprising (a) a first DNA sequence to which RNA polymerase binds which DNA sequence comprises a mRNA initiation site; and further (b) one or more DNA sequence(s) to...

20060240523 - Endogenous and non-endogenous versions of human g protein-coupled receptors: The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor and to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity....

20060240516 - Interacting polypeptide comprising a heptapeptide pattern and a cell penetration domain: The invention relates to an interacting polypeptide consisting of or comprising a heptapeptide pattern of sequence X1X2X3X4X5X6X7 and a transduction domain, characterized in that it is a chimera polypeptide, the amino acid X7 is located between 5 and 35 amino acids of the C-terminal end of said polypeptide, and that...

20060240510 - Method for designing peptides: The present invention relates to genetic engineering and; in specific, to design, generation, and modification of recombinant peptides using a combination of phage display and intein-mediated protein cleavage reaction....

20060240509 - Myrothecium sp transformation and expression system: The present invention is related to a transformation and an expression system in which Myrothecium sp. host cells are used to express homologous or heterologous proteins or are used to genetically engineer metabolic pathways....

20060240517 - Novel receptor nucleic acids and polypeptides: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided....

20060240518 - Novel receptor nucleic acids and polypeptides: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided....

20060240519 - Novel receptor nucleic acids and polypeptides: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided....

20060240520 - Novel receptor nucleic acids and polypeptides: Disclosed are nucleic acids encoding BAFF-R polypeptides, as well as antibodies to BAFF-R polypeptides and pharmaceutical compositions including the same. Methods of treating tumorigenic and autoimmune conditions using the nucleic acids, polypeptides, antibodies and pharmaceutical compositions of this invention are also provided....

20060240522 - Process for bacterial production of polypeptides: Refractile particles containing a heterologous polypeptide as an insoluble aggregate are recovered from bacterial periplasm. The process involves culturing bacterial cells so as to express nucleic acid encoding phage lysozyme and nucleic acid encoding the heterologous polypeptide under separate promoters, disrupting the cells mechanically to release the phage lysozyme so...

20060240512 - Pt32 sperm protein, sperm c-yes, oocyte cytoplasmic c-yes, and uses thereof: The perinuclear theca 32 (PT32) protein is disclosed and shown to interact with tyrosine kinase c-Yes. PT32, c-Yes, fragments thereof, and molecules that bind thereto can be used in methods of enhancing fertility, treating or diagnosing diminished fertility and abnormal spermiogenesis, in providing contraception, and in identifying contraceptive and fertility-enhancing...

20060240511 - Purification of her-2 variants: The present invention provides for a novel method for purification of EGFR family proteins obtained from cultures of insect cells. The process comprises subsequent steps of a) diafiltration and exchange of culture medium with buffer, b) immobilized metal affinity chromatography (IMAC), c) size exclusion chromatography (SEC), and d) anion exchange...

20060240515 - Soluble fragments of the sars-cov spike glycoprotein: The invention relates to the spike protein from the virus (SARS-CoV) that is etiologically linked to severe acute respiratory syndrome (SARS); polypeptides and peptide fragments of the spike protein; nucleic acid segments and constructs that encode the spike protein, polypeptides and peptide fragments of the spike protein, and coupled proteins...

20060240524 - Factor vii or viia - like molecules: Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates are provided. Methods of treatment by administering a FVII or FVIIa conjugate are provided....

20060240525 - Factor vii or viia - like molecules: Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates are provided. Methods of treatment by administering a FVII or FVIIa conjugate are provided....

20060240526 - Fvii or fviia gla domain variants: Gla domain variants of human Factor VII or human Factor VIIa, comprising 1-15 amino acid modifications relative to human Factor VII or human Factor VIIa, wherein a hydrophobic amino acid residue has been introduced by substitution in position 34; or having an amino acid substitution in position 36; and use...

20060240527 - Process for producing fine self-aggregates: a

20060240528 - Polyketides and their synthesis: A polyketide synthase (“PKS”) of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further ketide unit which may undergo processing (e.g. reduction)....

20060240529 - Process for the preparation of fludarabine phosphate from 2-fluoroadenine and fludarabine phosphate salts with amines or ammonia: The invention provides a process for the preparation of fludarabine phosphate from 2-fluoroadenine and 9-β-D-arabinofuranosyl-uracil using Enterobacter aerogenes (EBA). 2-Fluoroadenine is reacted with 9-β-D-arabinosyl-uracile in a water solution at pH=7 in the presence of EBA cell paste, to yield fludarabine. Fludarabine is then treated with acetic anhydride and the resulting...

20060240530 - Methods and compositions for infectious cdna of sars coronavirus: The present invention provides a cDNA of a severe acute respiratory syndrome (SARS) coronavirus, recombinant SARS coronavirus vectors, and SARS coronavirus replicon particles. Also provided are methods of making the compositions of this invention and methods of using the compositions as immunogens and/or vaccines and/or to express heterologous nucleic acids....

20060240531 - Processes for producing isomaltose and isomaltitol and use thereof: The present invention aims to provide a novel process for producing isomaltose and isomaltitol, and uses thereof, and it solves the object by establishing a process for producing isomaltose comprising a step of contacting a saccharide, having the α-1,4 glucosidic linkage as the linkage of non-reducing end and a glucose...

20060240532 - Dna encoding hydantoinase, dna encoding n-carbamyl-l-amino acid hydrolase, recombinant dna, transformed cell, method of producing protein and method of producing optically active amino acid: The present invention provides a method of producing optically active amino acids from 5-substituted hydantoin by isolating a hydantoinase gene and an N-carbamyl-L-amino acid hydrolase gene involved in an ability to convert 5-substituted hydantoin or N-carbamylamino acid into optically active amino acids from a microorganism of the genus Microbacterium having...

20060240533 - Assembly for the stabilisation of vertebral bodies of the spine: An assembly for the stabilisation of vertebral bodies (12, 14) of the spine is described. It comprises a pair of pedicle screws (20) each having a threaded shaft (20a) with a tapering first end (20b) for introduction into a vertebral body and a head portion (20c) with a second end...

20060240534 - Process for producing scyllo-inositol: It is intended to provide a novel NAD+-independent myo-inositol 2-dehydrogenase which converts myo-inositol into scyllo-inosose in the absence of NAD+; a novel enzyme scyllo-inositol dehydrogenase which stereospecifically reduces scyllo-inosose into scyllo-inositol in the presence of NADH or NADPH; and a novel microorganism which belongs to the genus Acetobacter or Burkholderia...

20060240535 - Carbonyl reductase from lactococcus lactis: Compositions and methods of using a carbonyl reductase from Lactococcus lactis (LLCR or LL-CR) are provided. One aspect provides an isolated polypeptide from Lactococcus lactis, wherein the polypeptide is an (R)-specific carbonyl reductase or a fragment thereof and reduces acetophenone or alph,beta-unsaturated carbonyl compound to form a reduced R enantiomeric...

20060240536 - Fermentation broth extraction of k-252a: Methods for separating K-252a from the cell mass of its parent fermentation broth are disclosed....

20060240537 - Plants with increased phosphorous uptake: The invention provides plant acid phosphatase coding sequences. Also provided are constructs comprising these sequences, plants transformed therewith and methods of use thereof. In certain aspects of the invention, transgenic plants are provided exhibiting improved phosphorous utilization....

20060240538 - Cell separation method using alumina: A method of separating cells or viruses using alumina is provided. The method includes: contacting a solution containing cells or viruses with alumina; and washing the alumina having cells or viruses bound thereto. According to the method, the separation efficiency of cells or viruses can be increased, the detection limit...

20060240539 - Texturizing lactic bacteria: The invention relates to a novel strain of lactic bacteria comprising at least one sequence selected from a group consisting of nucleotide sequences SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5, SEQ ID No. 6, SEQ ID No....

20060240540 - Biosensor, biosensor chip, and biosensor device: A biosensor device includes a biosensor having a plurality of biosensor sections each including a working pole and a counter pole. The biosensor device further includes a singal processing circuit for measuring a current flowing from the working pole when different voltages are applied between the working poles and the...

20060240541 - Lateral flow assay systems and methods: In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of...

20060240542 - Substrate support lift mechanism: An apparatus for positioning a substrate support within a processing chamber is provided. In one embodiment, an apparatus for positioning a substrate support includes a yoke comprising a curved surface with a first slot formed therethrough, a base comprising a first surface adapted to support the substrate support and a...

20060240543 - Microwell arrays with nanoholes: A device for conducting parallel analysis or manipulation of multiple cells or biomolecules is disclosed. In one embodiment, the device comprises a silicon chip with a microwell, and at least one membrane suspended at the bottom opening of the microwell. The suspended portion of the membrane defines a nanohole that...

20060240544 - Bioreactor for growing fungus, plant cell, tissue, organ, hairy roots and plantlet: A bioreactor includes a nutrient reservoir, a rotatable culture bed, at least one culture medium, a mist generator and a mist delivery pipe. The nutrient reservoir stores therein a nutrient solution required for the fungus, plant cell, tissue, organ, hairy roots and plantlet. The rotatable culture bed is rotated at...

20060240545 - Flow cell and a reactor for reactions between fixed reacting substances and liquid reacting substances, and a method for operating the reactor: A flow cell having a first plate having a continuous groove formed as a passage on one surface of the plate and having gas/liquid inlet/outlet portions at both the ends of the continuous groove, and a second plate to be kept in contact with said one surface of the first...

20060240546 - Tube ports and related container systems: A tube port includes a tubular first stem having an interior surface and an exterior surface extending between a first end and a longitudinally spaced apart second end. The interior surface bounds a passage that longitudinally extends through the first stem. The tube port also includes a flange encircling and...

20060240547 - Linear and membrane-like biodevices and bioreactors: A linear biodevice is provided with fibers that have a curved portion in its cross section approximately perpendicular to the longitudinal direction and approximately spherical adhesive cells that adhere to the periphery of the fiber. A membrane-like biodevice is provided with a sheet that has an opening and approximately spherical...

20060240548 - Materials for constructing cell-chips, cell-chip covers, cell-chips coats, processed cell-chips and uses thereof: A chip-device is provided for holding living cells in a plurality of wells disposed on the surface of a carrier, characterized in that the wells are configures to influence the proliferation of living cells in the wells, for example by changing the size of the wells, delaying or inhibiting cell-proliferation,...

20060240549 - Lockable cell growth chamber: A lockable cell growth chamber is disclosed wherein the lid and base of the dish are provided with at least two pairs of locking members, each comprising a notched docking member and a docking member-engaging tab....

20060240550 - Three-dimensional cell to tissue development process: The present invention relates to an improved three-dimensional cell to tissue development process using a specific time varying electromagnetic force, pulsed, square wave, with minimum fluid shear stress, freedom for 3-dimensional spatial orientation of the suspended particles and localization of particles with differing or similar sedimentation properties in a similar...

20060240551 - Neutralizing monoclonal antibodies against severe acute respiratory syndrome-associated coronavirus: The present invention provides an isolated antibody capable of binding to the receptor-binding domain of the spike protein of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) so as to competitively inhibit the binding of the SARS-CoV to host cells. These mAbs or substances can be used: 1) as passive-immunizing agents...

20060240552 - Anterior ocular-associated cell sheet, three-dimensional construct and process for producing the same: An anterior ocular segment related cell sheet or three-dimensional structure that have only a few structural defects as they have been recovered retaining the intercellular desmosome structure and the basement membrane-like protein between cell and substrate. The anterior ocular segment related cell sheet or three-dimensional structure is produced by a...

20060240553 - Cultures of human cns neural stem cells: The invention provides a cell culture including proliferating human neural stem cells with a doubling rate faster than thirty days. The invention also provides a cell culture media for proliferating mammalian neural cells including a standard defined culture medium, a carbohydrate source, a buffer, a source of hormones, one or...

20060240554 - Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules: The present invention relates to novel cationic lipids, transfection agents, microparticles, nanoparticles, and short interfering nucleic acid (siNA) molecules. The invention also features compositions, and methods of use for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of gene expression and/or activity in...

20060240555 - Fibrin cell supports and method of use thereof: The present invention relates to fibrin cell supports for cell cultures formed by the mixture of plasma proteins including fibrinogen and thrombin. The fibrin cell supports are preferably used for preparing a culture of cells such as keratinocytes, recovering the culture in the form of a reconstituted tissue, and transporting...

20060240556 - Use of rna interference for the creation of lineage specific es and other undifferentiated cells and production of differentiated cells in vitro by co-culture: Methods for making human ES cells and human differentiated cells and tissues for transplantation are described, whereby the cells and tissues are created following somatic cell nuclear transfer. The nuclear transfer donor is genetically modified prior to nuclear transfer such that cells of at least one developmental lineage are de-differentiated,...

20060234203 - Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent: Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of a pharmaceutical agent are described....

20060234204 - Method for vitrification of a biological specimen: The present invention relates to a method of vitrification of a biological specimen. According to the method of the present invention, a biological specimen is directly exposed to a freezing material. Upon exposure to the freezing material, the biological specimen undergoes vitrification. The biological specimen which has undergone vitrification may...

20060234207 - Device for evaluating in vitro cell migration under flow conditions, and methods of use thereof: The current invention is directed towards a device that useful for studying cell migration. It is preferred that the device is configured to study stem cell, particularly hematopoetic stem/precursor cell homing. The device allows for detailed analysis of the various phases of the multiphase homing process. There are also provided...

20060234206 - Fluorescent probes for biological studies: e

20060234205 - In vitro test system for predicting patient tolerability of therapeutic agents: Methods for predicting patient tolerability to therapeutic agents, such as cytokines, lymphokines and immunotoxins, are disclosed. The methods utilize an in vitro model of vascular leak syndrome (VLS) to assess the effect of the agent in question on the permeability of large proteins across confluent monolayers of endothelial cells (EC)....

20060234210 - Filtration device and method for removing selected materials from biological fluids: A filter and method for removing selected materials from a biological fluid sample are provided. The filter comprises an outer housing, inlet, and outlet. A plurality of filter surfaces are provided within the outer housing, and at least one coating is applied to the filter surfaces. The at least one...

20060234212 - Hepatitis-b viral variants with reduced susceptibility to nucleoside analogs and uses thereof: The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues, both in vivo and in vitro. More in particular, reverse transcriptase mutant rtA181S is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in monitoring...

20060234214 - Methods of detecting hepatitis c virus: The present invention provides a sensitive and specific test for hepatitis C virus. The test detects the presence of particular core antigens of hepatitis C, which appear earlier after initial infection than antigens or viral genetic materials used in previously-developed assays. The invention test allows detection of hepatitis C infection...

20060234209 - Microchip-based system for hiv diagnostics: The invention relates to microchip-based assays to measure HIV-associated analytes of interest (e.g., CD4 lymphocytes, HIV RNA and liver enzymes) in a sample from a subject infected with the HIV virus. Methods of the present invention are optimal for use in monitoring HIV disease in resource-poor settings....

20060234208 - Novel mechanism for hiv-1 entry into host cells and peptides inhibiting this mechanism: This invention relates to the finding that TAT interacts with gp120 at the cell surface and enhances HIV-1 entry into host cells. This invention also discloses modulators of this interaction, particularly peptides that mimic the region of gp120 involved in this interaction. These peptides interfere with TAT-mediated enhancement of infection...

20060234211 - Peptides for detection of antibody to porcine reproductive respiratory syndrome virus: The invention provides compositions and methods for the detection and quantification of PRRSV antibodies and antibody fragments using polypeptides....

20060234215 - Rapid exchange luminescence (rel) for high sensitivity detection: A bioswitch is described which includes a long-lived emitter such as a lanthanide luminophore for time gated detection of ligand binding without interfering background signal....

20060234213 - Synthetic peptides useful in biological essays for detecting infections caused by group o hiv-1 viruses: wherein Δis a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH3CO—) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -1-Ser-2-, -1-Gln-2-, or -1-Asn-2-, wherein -1 represents a peptide sequence of 0...

20060234223 - Association of snps in the comt locus and neighboring loci with schizophrenia, bipolar disorder, breast cancer and colorectal cancer: Methods and kits used for determining predisposition and/or diagnosis of schizophrenia, bipolar disorder, breast cancer and colorectal cancer using genotypes in the COMT locus are disclosed. Also disclosed are methods and drugs for treating these disorders. Further disclosed are methods and kits useful for prediction drug responsiveness towards mental disorders...

20060234221 - Biallelic markers of d-amino acid oxidase and uses thereof: The invention concerns the human DAO gene, polynucleotides, and biallelic markers. The invention also concerns the association established between schizophrenia and the biallelic markers. The invention provides means to determine the predisposition of individuals to schizophrenia or related CNS disorder, as well as means for the disease diagnosis and prognosis....

20060234267 - Bioarray chip reaction apparatus and its manufacture: A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the...

20060234237 - Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators: EGFR biomakers useful in a method for identifying a mammal that will respond therapeutically to a method of treating cancer comprising administering an EGFR modulator, wherein the method comprises (a) exposing the mammal to the EGFR modulator and (b) measuring in the mammal level of at least one biomaker, wherein...

20060234259 - Biomarkers for predicting prostate cancer progression: The present invention relates to the identification and use of gene expression profiles with clinical relevance to prostate cancer. In particular, the invention provides the identity of genes whose expression, at the transcriptional and protein levels, is correlated with prostate cancer progression. Methods and kits are described for using these...

20060234287 - Breast cancer progression signatures: Methods and compositions for the identification of breast cancer progression signatures are provided. The signature profiles are identified based upon multiple sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for identification of cells as being in one or...

20060234260 - Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection: The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors...

20060234254 - Colon cancer biomarker discovery: The present application discloses an epigenetic marker for colon cancer....

20060234261 - Colorimetric readout of hybridization chain reaction: The present invention relates to the use of calorimetric hybridization chain reaction (HCR) to detect the presence of one or more target analytes in a sample. In the preferred embodiments, metastable nucleic acid monomers are provided that associate in the presence of an initiator nucleic acid. Upon exposure to the...

20060234248 - Composite organic inorganic nanoclusters: Metallic nanoclusters capable of providing an enhanced Raman signal from an organic Raman-active molecule incorporated therein are provided. The nanoclusters may be further functionalized, for example, with coatings and layers, such as adsorption layers, metal coatings, silica coatings, probes, and organic layers. The nanoclusters are generally referred to as COINs...

20060234247 - Correction of alpha-1-antitrypsin genetic defects using spliceosome mediated rna trans splicing: The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosomal mediated RNA trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a SERPINA1 target precursor messenger RNA molecule (target pre-mRNA) and mediate a trans-splicing reaction resulting in the generation...

20060234240 - Diagnostics and therapeutics for diseases associated with 5-hydroxytryptamine 1f receptor (5-ht1f): The invention provides a human 5-HT1F which is associated with the hematological diseases, disorders of the peripheral and central nervous system, gastrointestinal diseases, cardiovascular diseases, cancer, muscle/skeleton disorders, respiratory diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of...

20060234256 - Double stranded rna receptor (dsrna-r) and methods relating thereto: The present invention is directed to nucleic acid molecules and polypeptides encoding a dsRNA receptor (dsRNA-R). The dsRNA-R contains a THD, interacts with the MyD88 adapter protein, and may bind to dsRNA. The present invention is also directed to antibodies against dsRNA-R and to methods of modulating an immune response...

20060234280 - Enyzmes having alpha amylase activity and methods of making and using them: The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases, and methods of making and using them. In addition methods of designing new alpha amylases and methods of use thereof are also provided. The alpha amylases have increased activity and stability at increased pH and temperature....

20060234283 - Fungal cell wall synthesis gene: A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these...

20060234246 - Gene products differentially expressed in cancerous cells: The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer....

20060234216 - Haplotype structures of chromosome 21: The present invention includes the use of any of the polymorphisms, SNP haplotype blocks or SNP haplotype patterns. In one embodiment, susceptibility to a phenotype resulting from an allele or marker in linkage disequilibrium with such polymorphic forms is evaluated. Novel therapeutic and diagnostic compounds and methods are also disclosed....

20060234225 - Height-related gene: The application relates to isolated regions and genes from the Y chromosome which encompass the Y specific growth gene GCY. Probes and primers are also provided....

20060234227 - Helix-hairpin-helix motifs to manipulate properties of dna processing enzymes: The utility of Topo V's HhH motifs for modulating DNA binding properties of a DNA processing enzyme, such as Taq DNA polymerase or PfuDNA polymerase, is demonstrated. In one embodiment, an amino acid residue comprising one or more HhH domains derived from Topoisomerase V, linked to either the NH2-terminus or...

20060234286 - Human paris-1 antigen and nucleic acids: diagnostic and therapeutic uses: The present invention relates to the discovery, identification and characterization of a novel tumor suppressor gene designated PARIS-1. The invention includes nucleotide sequences of the PARIS-1 gene and amino acid sequences of its encoded protein product(s), as well as fragments, derivatives and analogs thereof. The invention also includes the production...

20060234273 - Id-1 and id-2 genes and products as markers of epithelial cancer: A method for detection and prognosis of breast cancer and other types of cancer. The method comprises detecting expression, if any, for both an Id-1 and an Id-2 genes, or the ratio thereof, of gene products in samples of breast tissue obtained from a patient. When expressed, Id-1 gene is...

20060234269 - Laser modification and functionalization of substrates: Assay devices comprising substrates functionalized to comprise probe species on multiple separate regions are provided. Ten thousand to a hundred thousand separate regions can be provided in a substrate of one square centimeter. The separate regions can comprise separate probe species, or in another embodiment, multiple different probe species can...

20060234268 - Linear amplification of rna: The present application discloses a method for linear amplification of RNA....

20060234236 - Method and device for pcr-amplification and detection of nucleotide sequences: A DNA-Chip includes a flat carrier and an array of spots containing probe molecules (oligonucleotides) which are arranged on said carrier. Each spot is associated with a microelectrode arrangement for impedance spectroscopic detection of binding events occurring between the probe molecules and target molecules (DNA fragments) applied by way of...

20060234224 - Method and nucleic acids for the analysis of colon cell proliferative disorders: The invention provides methods and nucleic acids for detecting, differentiating or distinguishing between colon cell proliferative disorders by analysis of one or more of the genes Versican, TPEF, H-Cadherin, Calcitonin, and EYA4. The invention further provides novel nucleic acid sequences useful for the cell proliferative disorder specific analysis of said...

20060234275 - Method for collecting purified cells: The present invention provides improved methods for collecting cells for subsequent analysis. More specifically, the invention provides methods for collecting purified cell samples from a flow cytometer onto a solid support on which cell lysis occurs and genetic material is immobilized....

20060234253 - Method for detecting a target substance by using a nucleic acid probe: A method for detecting a target substance is described, which comprises the steps of: forming a first complex comprising (a) a first nucleic acid probe immobilized on a first solid phase and having a single-strand portion, (b) a nucleic acid ligand which has a binding section as a base sequence...

20060234219 - Method for detecting and identifying microorganism causative of infection: Causative microorganisms of infectious diseases are detected and/or identified rapidly and high-sensitively by taking phagocytes from the clinical specimens containing active phagocytes, immobilizing the phagocytes so taken, treating the phagocytes to improve cell membrane permeabilities thereof, further treating the phagocytes to bare DNA in the causative microorganisms which might be...

20060234263 - Method for reducing the presence of amplification inhibitors in a reaction receptacle: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a...

20060234277 - Method for selectively blocking hemoglobin rna amplification: This invention provides oligonucleotides, compositions, kits, and methods for specifically blocking amplification of hemoglobin mRNA in a sample of RNA. The oligonucleotides and methods are particularly advantageous for analyzing samples of RNA extracted from whole blood samples....

20060234230 - Method of detecting gene polymorphism: A method for detecting a genetic polymorphism(s) in a gene encoding cytochrome P450 using as oligonucleotide probes and/or oligonucleotide primers at least one sequence selected from the group consisting of an at least 13 nucleotide sequence within any of the nucleotide sequences as shown in SEQ ID NOS: 1 through...

20060234228 - Method of identifying nucleic acid: Test nucleic acids are identified by the steps of: synthesizing multiple nucleic acids that comprise nucleotide sequences complementary to different regions of a test nucleic acid; and comparing the dissociation curve of a mixture of the synthesized nucleic acids. The dissociation curve of a mixture of nucleic acids shows a...

20060234235 - Methods and compositions for the diagnosis of neuroendocrine lung cancer: This invention relates to methods and compositions for the diagnosis of neuroendocrine lung cancers. In particular, the invention concerns the use of cDNA microarrays to facilitate the differential diagnosis of neuroendocrine tumor types....

20060234252 - Methods and kits for methylation detection: Methods for determining the methylation state of at least one target nucleotide that employ a reaction catalyzed by a structure-specific nuclease, typically coupled with a ligation reaction are disclosed. By detecting the cleaved flap, a ligation product, a ligation product surrogate, a hybridization complex, or combinations thereof, one can infer...

20060234266 - Methods for detecting multiple species and subspecies of neisseria: Disclosed are methods, kits, and other components for detecting multiple nucleic acids in a sample. The methods and kits may be useful for detecting Neisseria in a sample. In some embodiments, the methods include (a) reacting a mixture that includes (i) nucleic acid isolated from the sample; (ii) at least...

20060234242 - Methods for identifying therapeutic targets involved in glucose and lipid metabolism: The identification and evaluation of mRNA