Chemistry: molecular biology and microbiology inventions 04/06

20060088814 - Enhanced cell preservative solution and methods for using same: The present invention relates to an aqueous alcohol buffer solution for substantially ambient, in vitro preservation of mammalian cells for a selected duration....

20060088813 - Glyoxal/zinc fixative: This invention provides compositions and methods for fixing a biological sample, particularly fecal samples for diagnosis of parasitic infection. The fixative composition of the present invention comprises glyoxal (pyruvate aldehyde) and zinc sulfate and permits staining of biological samples without use of toxic compounds, such as formaldehyde and mercury-containing compounds....

20060088816 - Detection of transmembrane potentials using n,n,n'-trialkyl thiobarbituric acid-derived polymethine oxonols: i

20060088815 - Method for evaluation of endocrine disruptive action: There is provided a method for a quick and easy evaluation of a substance which is an object of evaluation for its endocrine disruptive action. An evaluating method according to the present invention is a method for the evaluation of endocrine disruptive action which is characterized in comprising a step...

20060088817 - Method of determining plant species with pyrolysis-gas chromatography: A method of identifying a plant species includes the steps of: preparing a fragment of the plant; heating the fragment to obtain lignin from the fragment; gasifying the lignin at a high temperature to obtain components of the lignin; obtaining a flux profile of the components; and determining the species...

20060088820 - Detecting superantigen activity in a biological sample: Multiple sclerosis or a condition associated with multiple sclerosis is detected by detecting an amount of lymphocytes bearing a Vβ16, Vβ17 or Vβ7 determinant and calculating an amount of expansion or loss of these lymphocytes....

20060088818 - Optical detection of microorganisms and toxins: A method of detecting the presence of selected microorganisms within a fluid includes filtering the fluid to remove large particles prior to analyzing the fluid with an antibody matrix. Non-specific binding is eliminated by washing and the presence of biological material is detected. If biological material is detected within the...

20060088819 - Truncated hepatitis c virus ns5 domain and fusion proteins comprising same: The invention provides truncated HCV NS5 polypeptides and fusion proteins comprising the truncated NS5 polypeptides, fused to at least one other HCV epitope derived from another region of the HCV polyprotein. The fusions can be used in methods of stimulating an immune response to HCV, for example a cellular immune...

20060088872 - Allele-specific mutation detection assay: The present invention relates to a method of detecting a base at a pre-determined position in a nucleic acid molecule by performing enzymatic detection reactions using base-specific detection oligomers, where each oligomer is specific for a particular base at the predetermined position, and then comparing the enzymatic detection reactions to...

20060088864 - Aptamer regulated nucleic acids and uses thereof: The invention relates to trans-acting ligand-responsive nucleic acids and uses thereof. In particular, a ligand responsive nucleic acid comprises an effector domain and an aptamer domain that is responsive to a ligand....

20060088847 - Arf-bp1 as mediator of p53-dependent and independent tumor suppression and uses thereof: The present invention relates to the mechanism of ARF-mediated cell growth suppression. ARF-BP1 is identified as a novel ubiquitin ligase, and a major component of ARF-containing nuclear complexes in human cells. The present invention discloses a novel mechanism of ARF-mediated p53 activation and that ARF-BP1 is a critical mediator of...

20060088863 - Automated method of manufacturing polyer arrays: The present invention provides methods to process multiple sensors by providing a sensor plate and HT plates. In a preferred embodiment of the invention, methods for assembling microarray pegs and microarray plates are described for high throughput microarray processing....

20060088849 - Compositions and methods for the diagnosis of group b streptococcus infection: The present invention relates to methods of detecting a Group B Streptococcus (GBS) bacterium in a sample. In particular, the present invention provides compositions, kits and methods for detecting the gbs1539 gene of a GBS bacterium....

20060088821 - Construction and use of catalogued nucleic acid libraries that contain advantageously adjusted representations of defined components: A process for constructing a catalogued nucleic acid library in which the proportional representation of the constituents is adjusted to advantage through the use of disclosed technologies for positive and negative selection. The resultant benefit is that significantly fewer library constituents will need to be screened in order to identify...

20060088833 - Detection of mycobacteria in clinical material: The present invention relates to a molecular biological method for the specific detection of mycobacteria and for the differentiation of the Mycobacterium tuberculosis complex and Mycobacterium avium from other mycobacteria in clinical material by means of amplification primers and oligonucleotide probes which are specific for the genus- and species-specific regions...

20060088827 - Diagnostic and therapeutic use of a voltage-gated ion channel scn2a for neurodegenerative diseases: The present invention discloses the differential expression of the gene coding for the voltage-gated ion channel SCN2A in specific brain regions of Alzheimers disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer s disease, in a subject, or...

20060088826 - Discrimination and detection of target nucleotide sequences using mass spectrometry: A method for determining the presence or absence of at least one target sequence in a nucleic acid sample, comprising the steps of performing an oligonucleotide ligation assay, digesting the resulting amplified probes with a restriction enzyme isolating detectable fragments and the determining the presence of detectable fragments by mass...

20060088879 - Dna polymerases having improved labeled nucleotide incorporation properties: The present invention relates to mutant DNA polymerases that exhibit reduced discrimination against labeled nucleotides into polynucleotides. The DNA polymerases of the invention have at least one mutation in the nucleotide label interaction region of the enzyme such the mutation results in reduced discrimination against labeled nucleotides. The nucleotide label...

20060088862 - Drug screening and molecular diagnostic test for early detection of colorectal cancer: reagents, methods, and kits thereof: A novel approach to the early detection of colorectal cancer (“CRC”), using a molecular diagnostic test to evaluate grossly normal-appearing colonic tissue for the early detection of colorectal cancer is disclosed. Such grossly normal-appearing colonic mucosal cells may be collected from non-invasive or minimally invasive procedures. The use of novel...

20060088856 - Dual labeled fluorescent probes: The present invention relates to probes useful for the detection and measurement of target nucleic acids, as well as compositions and kits containing such probes. The probes of the present invention include an interactive pair of labels, as well as a hairpin sequence that does not hybridize to a target...

20060088871 - Dynamic genomic deletion expansion and formulation of molecular marker panels for integrated molecular pathology diagnosis and characterization of tissue, cellular fluid, and pure fluid specimens: Provided are materials, methods, platforms, and kits for diagnosing, prognosing, and/or determining the biological aggressiveness of a tumor (malignant and non-malignant) based in part on the temporal profile of genomic deletion expansion of the tumor. Also provided are methods of determining marker panels for different diseases and/or tissues and markers...

20060088837 - Expression system for stem-loop rna molecule having rnai effect: The present inventors discovered that an RNA molecule can be efficiently transferred into cytoplasm and exert RNAi effects, by producing a stem loop RNA molecule from the DNA that encodes this RNA molecule, with the use of a tRNA promoter. Also, the RNAi effects can be exerted effectively, by introducing...

20060088825 - Human delta-n p73 molecules and uses thereof: The present invention is in the field of molecular biology and genetics. More specifically, the invention relates to human ΔN p73, a novel gene associated with apoptosis regulation. The present invention provides and includes nucleic acid molecules, proteins and antibodies associated with ΔN p73 and methods utilizing such agents, for...

20060088861 - Information nucleic acid-carrying fine particles and production method thereof: Information nucleic acid-carrying fine particles to be used for individuality authentication for industrial products. The information nucleic acid-carrying fine particles include fine particles on which an information nucleic acid including a base sequence portion having an arbitrary and known base sequence is carried....

20060088851 - Invasion/migration gene: This invention relates to the detection of increased expression from the HoxB13 (homeobox B13) gene as indicative of an invasive or metastatic cancer phenotype. The invention provides methods of detecting the level of expression from the HoxB13 gene, optionally in combination with nodal status, as an indicator of the invasive...

20060088834 - Matrix analysis of gene expression in cells (magec): The invention provides a novel expression cloning technique referred to as a matrix analysis of gene expression in cells (MAGEC) that allows for the indexed introduction, and analysis of nucleic acids in a host cell. While normally one takes cells attached to a surface followed by contacting the cells with...

20060088875 - Means for electrical contacting or isolation of organic or inorganic semiconductors and a method for its fabrication: In a means for electrical contacting or isolation of organic or inorganic semiconductors in electronic and optoelectronic devices, particularly thin-film devices, the means comprises a substrate (1) in the form of a contact material (1a) or an isolating material (4). A charge transfer material (2) is provided patterned or unpatterned...

20060088860 - Metabolite markers for weight management: The present invention provides methods of using certain metabolite markers for predicting weight development or its related conditions of a subject. The present invention also provides compositions and kits useful for detecting metabolite markers of the present invention....

20060088845 - Method and apparatus for analyzing and generating human antibody amino acid and nucleic acid sequences: The invention provides methods, computer programs, data and databases, computer readable media, computer systems, and/or apparatus that use, compare or generate data corresponding to at least one partial antibody or antibody fusion protein nucleic acid or amino acid sequence, on recordable media or in computer memory, such as engineered antibody...

20060088840 - Method for analyzing body fluids for the presence of cancer cells, use thereof, corresponding analysis kits, and use of specific active substances for treating cancer: The present invention relates to a method for investigating body fluids for cancer cells, the use thereof and corresponding analysis kits, and the possibilities for cancer treatment derived therefrom. The method is based essentially on determining the expression of the manganese superoxide dismutase, thioredoxin reductase and/or glutathione peroxidase genes. Use...

20060088852 - Method for determining the homeostasis of hairy skin: The invention relates to a method for determining the homeostasis of hairy skin in vitro, to test kits and biochips for determining markers of hairy skin, in addition to the use of proteins, mRNA molecules or fragments thereof as markers of hairy skin. The invention also relates to a test...

20060088850 - Method for genome-wide analysis of palindrome formation and uses thereof: The present invention provides a method for rapidly detecting the genome-wide presence of palindrome formation. The method has demonstrated that somatic palindromes occur frequently and are widespread in human cancers. Individual tumor types have a characteristic non-random distribution of palindromes in their genome and a small subset of the palindromic...

20060088857 - Method for isolation of independent, parallel chemical micro-reactions using a porous filter: The present invention relates to methods and apparatuses for conducting densely packed, independent chemical reactions in parallel in fluid-permeable arrays. Accordingly, this invention also focuses on the use of such arrays for applications such as DNA sequencing, most preferably pyrophosphate sequencing, and DNA amplification....

20060088848 - Method for patterning large scale nano-fibrous surfaces using capillography: A method of assembling large numbers of nanoscale structures in pre-determined ways using fluids or capillary lithography to control the patterning and arrangement of the individual nanoscale objects and nanostructures formed in accordance with the inventive method are provided. In summary, the current method uses the controlled dispersion and evaporation...

20060088876 - Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the do: A method for the early diagnosis of breast, lung, pancreatic and colon growths and cancers as well as conditions associated with donor and recipient organ transplants, both before and after transplantation to identify and allow treatment of possible transplanted organ rejection and other disease conditions related and unrelated to the...

20060088839 - Method of detecting nucleic acid by using dna microarrays and nucleic acid detection apparatus: A nucleic acid contained in a sample is quantified with high accuracy. The procedure includes the step of allowing the sample containing a specific nucleic acid to interact with a DNA microarray provided with a plurality of nucleic acid probe parts having a nucleic acid probe capable of hybridizing to...

20060088836 - Methods and compositions for diagnosing and monitoring transplant rejection: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also...

20060088880 - Methods and compositions for the treatment and diagnosis of cellular proliferation disorders using 25943: The present invention relates to methods and compositions for the treatment and diagnosis of cellular proliferation disorders, including, but not limited to, breast cancer, ovarian cancer, lung cancer, and colon cancer. The invention further provides methods for identifying a compound capable of treating a cellular proliferation disorders disorder or modulating...

20060088881 - Methods and compositions for treating urological disorders using 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 or 6351 molecules: The present invention relates to methods for the diagnosis and treatment of a urological disorder or urological disorders. Specifically, the present invention identifies the differential expression of 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 and 6351...

20060088865 - Methods and compositions related thereto for detecting and identifying distinct species of nucleic acids from causative agents: Methods are described herein for detecting and identifying distinct species of nucleic acids, in a single container, for example, from a certain genus of infectious agents or otherwise causative agents comprising, for example, providing a forward PCR primer common to a homologous gene region between the distinct species, and providing...

20060088874 - Methods and kits for detecting mutations: Disclosed are, methods and kits for detecting mutations in DNA by comparing the size of an amplified microsatellite locus to the expected size. The methods and kits may used in various applications, including monitoring exposure of a cell or organism to a mutagen, evaluating the mutagenicity of an agent, and...

20060088831 - Methods for identifying large subsets of differentially expressed genes based on multivariate microarray data analysis: The present invention provides multivariate methods for identifying differentially expressed genes based on microarray expression data. An improved random search procedure involving certain probability distances is provided. The methods of this invention implement a successive elimination procedure to remove smaller subsets resulted from each step of the random search thereby...

20060088838 - Methods for improving a binding characteristic of a molecule: The present invention relates to methods for improving a binding characteristic of a molecule, e.g., a peptide, for a binding target, in which the molecule is covalently linked to a detectable moiety, e.g., an enzyme, or an active portion or derivative thereof. The present invention also relates to molecules produced...

20060088873 - Methods for smn genes and spinal muscular atrophy carriers screening: A method for SMN genes identifying is disclosed, as well as a method for spinal muscular atrophy carriers screening. The method comprises steps of following: (a) providing a genomic DNA; (b) amplifying the genomic DNA with a pair of primers; and (c) injecting the amplified product into DHPLC (Denaturing High...

20060088855 - Methods of using fet labeled oligonucleotides that include a 3'-5' exonuclease resistant quencher domain and compositions for practicing the same: Methods and compositions are provided for detecting a primer extension product in a reaction mixture. In the subject methods, a primer extension reaction is conducted in the presence of a polymerase having 3′→5′ exonuclease activity and at least one FET labeled oligonucleotide probe that includes a 3′→5′ exonuclease resistant quencher...

20060088846 - Methods to identify compounds useful for the treatment of proliferative and differentiative disorders: The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18,...

20060088823 - Microarray gene expression profiling in clear cell renal cell carcinoma : prognosis and drug target identification: A nucleic acid probe or a novel set of such probes in a microarray is provided. The probe or probe set is useful in the prognosis of patients with clear cell renal cell carcinoma (CC-RCC), wherein aggressive and non-agressive CC-RCC tumor types are characterized by differential expression profiles of genes...

20060088829 - Minrs as modifiers of insulin receptor signaling and methods of use: Human MINR genes are identified as modulators of INR signaling and thus are therapeutic targets for disorders associated with defective INR signaling. Methods for identifying modulators of MINR, comprising screening for agents that modulate the activity of MINR are provided....

20060088843 - Modified venom and venom components as anti-retroviral agents: The present invention relates to a class of proteins, a process of production thereof, and a method for treatment of neurological and viral diseases in humans and animals. More specifically it applies to the treatment of heretofore intractable diseases such as retro-viral infections including human immunodeficiency virus (HIV), simian immunodeficiency...

20060088858 - Modified venom and venom components as anti-retroviral agents: The present invention relates to a class of proteins, and a method for treatment of neurological and viral diseases in humans and animals. More specifically it applies to the treatment of heretofore intractable diseases such as retro-viral infections including human immunodeficiency virus (HIV), simian immunodeficiency virus (SIV), feline immunodeficiency virus...

20060088822 - Novel polymerase compositions and uses thereof: The subject invention provides novel compositions containing a mixture of (a) an enzyme that possesses substantial 3′-5′ exonuclease activity (b) a DNA polymerase with less 3′-5′ exonuclease activity than the enzyme with substantial 3′-5′ exonuclease activity. Preferably, the DNA polymerase for inclusion in the compositions are DNA polymerases that substantially...

20060088828 - Polycystic kidney disease nucleic acids and proteins: Nucleic acids and polypeptides are provided that are associated with autosomal recessive polycystic kidney disease. Antibodies against the polypeptides, vectors and host cells containing the nucleic acids, methods for using the nucleic acids, and compositions and articles of manufacture also are provided....

20060088830 - Protein biomarkers that distinguish prostate cancer from non-malignant cells: This invention provides organic biomolecule markers (e.g., proteins) useful for differentiating prostate cancer, prostate intraepithelial neoplasia or benign prostate hyperplasia, from a negative diagnosis (i.e. normal and benign prostate epithelial cells)....

20060088867 - Purification devices comprising immobilized capture probes and uses therefor: The present invention pertains to devices comprising at least one purification unit, used to purify and/or concentrate a target molecule contained within a test sample. Typically, the target molecule in a test sample will be a nucleic acid. These purified nucleic acids can be used in a variety of ways,...

20060088878 - Purification of recombinant proteins fused to multiple epitopes: The present invention provides novel identification polypeptides containing multiple copies of an antigenic domain joined in tandem to provide increased sensitivity for the detection and purification of target peptides, a cleavable linking sequence and optionally a spacer domain. Further provided are hybrid polypeptide molecules composed of an identification polypeptide and...

20060088866 - Quantitative methylation detection in dna samples: Described is a method for methylation detection in a DNA sample. An isolated genomic DNA sample is treated in a manner capable of distinguishing methylated from unmethylated cytosine bases. The pretreated DNA is amplified using at least one oligonucleotide primer, a polymerase and a set of nucleotides of which at...

20060088844 - Real-time pcr microarray based on evanescent wave biosensor: A system and method for simultaneous, quantitative measurement of nucleic acids in a sample. Fluorescently tagged amplicons of the target nucleic acids are localized on a substrate surface by hybridization to oligopobes that have been arrayed and tethered to the substrate surface in a pre-determined, two-dimensional pattern. The hybridized, amplicons...

20060088868 - Repair of nucleic acids for improved amplification: Methods and compositions are provided for repairing a polynucleotide so that it can be synthesized efficiently with improved fidelity and yield in, for example, an amplification reaction. This involves the use of a reaction mixture that includes a ligase and a cofactor selected from NAD+ or ATP and incubating the...

20060088859 - Reporter assay screens for protein targets in saccharomyces cerevisiae: The present invention comprises responsive promoters along with screening methods which make use of the promoters in order to identify anti-fungal substances....

20060088841 - Reversible, parallel and multitask cloning method and kit: The present invention is related to a reversible, parallel and/or multitask cloning method and kit, which improve the cloning of (preferably multiple) genetic element(s) in a nucleic acid construct such as vector or in chromosome of a cell and the rapid and efficient selection of said construct with a correct...

20060088842 - Rt-pcr-based cloning of human smn, the sma determining gene, and the construction of its expression plasmids: Spinal muscular atrophy (SMA) is a lethal autosomal recessive disease. The gene most highly associated with SMA is the survival motor neuron (SMN) gene. The present invention is a new procedure for the cloning of human SMN, the SMA determining gene, based on the reverse transcription (RT) and the polymerase...

20060088835 - Schizophrenia associated genes: The present invention relates to the identification of genes which have been disrupted in patients diagnosed as suffering from schizophrenia and/or bi-polar affective disorder, as well as proteins encoded by the gene and antibodies thereto and to uses of such products as medicaments for treating schizophrenia and/or affective psychosis. The...

20060088854 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060088853 - System and method for determining sizes of polynucleotides: The present invention relates to a method of determining whether a length of a first polynucleotide is equal to (a) a length of a second polynucleotide or (b) a length of a third polynucleotide. A sample including the first polynucleotide is provided. A first portion of the sample is combined...

20060088877 - Systematic evolution of ligands by exponential enrichment: chemi-selex: This application provides methods for identifying nucleic acid ligands capable of covalently interacting with targets of interest. The nucleic acids can be associated with various functional units. The method also allows for the identification of nucleic acids that have facilitating activities as measured by their ability to facilitate formation of...

20060088832 - Tap-70, a novel marker for epithelial tumors: Described are a novel marker protein associated with apithelial tumors, TAP-70, belonging to the family of aspartyl proteinases and nucleic acid molecules encoding TAP-70 polypeptides. Moreover, diagnostic and therapeutic uses based on the finding that TAP-70 is overexpressed throughout skin carcinogenesis are described....

20060088870 - Topographic genotyping for determining the diagnosis, malignant potential, and biologic behavior of pancreatic cysts and related conditions: The application relates to a method of a predicting the presence of invasive pancreatic cancer or high grade dysplasia, pre-cancerous pancreatic states and non-neoplastic conditions comprising detailed molecular analysis incorporating DNA quality and quantity, K-ras mutational analysis and a broad spectrum of tumor suppressor gene linked microsatellite LOH. Methods of...

20060088869 - Viral purification methods: The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filtration and column chromatography. Viruses and...

20060088824 - Wnv core protein/capsid interacting protein and uses of the same: Substantially pure WIP-1 and its use in assays to identify PAP-1/WIP-1 interaction inhibitors or WIP-1/WNV Cp interaction inhibitors are disclosed. Compositions comprising antisense sequences to prevent expression of WIP-1 and methods of treating cancer using the same are disclosed....

20060088885 - Immunoassays for topiramate: Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antigenic moieties that can be used in immunodiagnostic assays for topiramate. Also, the...

20060088887 - Method for screening substance which can bind to receptor: A method for screening a substance which can optimally bind to a receptor, by monomolecular fluorescent analysis, comprising a step of searching a substance which can bind to a receptor, and a step of performing optimization of a structure of the substance which can bind to the receptor obtained by...

20060088884 - Method of utilizing neurotrophins to manipulate reproductive capacity: Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins, particularly BDNF, NT-4/5, and NGF, increase the reproductive capacity of a female patient by binding to receptors on the oocytes and stimulating maturation of...

20060088882 - Methods for the treatment or prevention of obesity: The invention provides methods for the treatment or prevention of obesity. The invention also provides screening methods for determining whether a compound is useful for the treatment or prevention of obesity....

20060088888 - Methods of identifying inhibitors of gadd45 polypeptide activity, and inhibitors of such activity: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability...

20060088889 - Peptides for use in culture media: The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by...

20060088883 - Recombinant catalytic polypeptides and their uses: The present invention provides a recombinant catalytic polypeptide for cleaving a target protein, the nucleic acid encoding the recombinant catalytic polypeptide, a cell hosting the nucleic acid encoding the recombinant catalytic polypeptide, and a non-human transgenic mammal that is capable of producing a heterologous antibody with proteolytic activity. The invention...

20060088886 - Topiramate analogs: Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antigenic moieties that can be used in immunodiagnostic assays for topiramate. Also, the...

20060088890 - Identification and isolation of somatic stem cells and uses thereof: The present invention relates to the identification of a specific population of cell types, in particular somatic stem cells including haematopoietic stem cells, mesenchymal stem cells and keratinocyte stem cells. The invention also provides for methods of isolation and uses of the stem cells. Derived from the methods of the...

20060088891 - Method of evaluating myelosuppressive state: The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By establishing threshold levels of certain cytokines as a surrogate for myelosuppression, treatment protocols can be optimized to reduce myelotoxicity, while maximizing effective...

20060088892 - Detection of trichomonas: The present invention is directed to diagnostic devices and methods for detecting Trichomonas infections....

20060088894 - Prostate cancer biomarkers: Protein biomarkers that may advantageously be utilized in diagnosing prostate cancer, benign prostate hyperplasia or to make a negative diagnosis are described. Accordingly, in one aspect of the invention, methods for aiding in, or otherwise making, a diagnosis of prostate cancer or benign prostate hyperplasia are provided. In one form...

20060088893 - Prostate cancer therapeutics and diagnostics based on conformers of prostatic cid phosphatase: The signals that determine important characteristics of prostate cancer, such as loss of dependence on androgens are described. A key protein, prostatic acid phosphatase, is shown to fold in different ways in response to cellular signals, and the conformer “mix” of this protein in prostatic cells may represent a fundamental...

20060088895 - Systems, methods and reagents for the detection of biological and chemical agents using dynamic surface generation and imaging: Techniques for the sensitive detection of analytes which combine the benefits of solution/suspension phase assay formats and the simplicity of solid phase/lateral flow assays are described. The assays can be performed in the solution/suspension phase using magnetic microspheres as a solid support. Subsequently a magnetic separation can be performed to...

20060088896 - Diagnostic device for rapid determination of buprenorphine: This invention relates to a method of detecting buprenorphine in biological fluids (especially urine), and to a device and kit which use chromatographically mobile reagents labelled with gold clusters. The method involves contacting urine sequentially with anti-buprenorphine antibodies labelled with gold clusters and with buprenorphine immobilised on a porous support,...

20060088897 - Modulators: Disclosed is an isoform-specific antagonist of PAK kinase, which is preferably a molecule capable of modulating an interaction between Nck and a PAK isoform. In particular, αPAK, βPAK and γPAK specific inhibitors are disclosed. Also included are methods of treating diseases, preferably characterised by a defect in nerve regeneration, comprising...

20060088898 - Methods for the production of cells and mammals with desired genetic modifications: The present invention features novel methods for generating cell lines and mammals with site-specific genetic modifications of interest. The methods involve homologous recombination between an artificial chromosome having a modification of interest and an endogenous chromosome of a cell. The resulting modified cells can be used in standard methods to...

20060088899 - Combination chemotherapy with chlorotoxin: This invention includes compositions and methods for combination chemotherapy, particularly involving at least one chemotherapeutic agent used in combination with chlorotoxin or a derivative thereof....

20060088900 - Method for determining inhibition activity of a compound on one of the enzymes of the folate synthesis pathway: The invention is directed to a method for determining the inhibition activity of a compound to be tested on at least the DHPS activity of the folate synthesis pathway, which is coupled with the detection of the release of formed inorganic phosphate. An enzymatic assay, implementing this method of determination...

20060088901 - Methods and kits for determining ubiquitin protein ligase (e3) activity: The present invention provides a method and an assay kit for detecting ubiquitin ligase (E3) activity in a sample. The method includes the steps of (1) preparing a sample mixture comprising ubiquitin, a ubiquitin activating enzyme (E1), a ubiquitin conjugating enzyme (E2), a reaction buffer, and the sample; (2) incubating...

20060088902 - Methods and materials for the identification of antifungal substrates in filamentous fungi: The present invention relates to a method for the identification of antifungal substrates, in particular substrates which are capable of combating filamentous fungi by disturbing cell wall biogenesis. A nucleotide sequence encoding α-1,3-glucan synthase including its promoter sequences is provided, obtainable from Aspergillus niger, which can be used to develop...

20060088903 - Method for the production of zymosterol and/or the biosynthetic intermediate and/or subsequent products thereof in transgenic organisms: The present invention relates to a method for preparing zymosterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts, which, compared to the wild type, have an increased lanosterol-C14-demethylase activity and increased HMG-CoA-reductase activity, to the nucleic acid constructs required for preparing the genetically modified...

20060088904 - Methods for the synthesis of astaxanthin: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished...

20060088905 - Methods for the synthesis of zeazanthin: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished...

20060088906 - Erythropoietin: remodeling and glycoconjugation of erythropoietin: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide....

20060088912 - Compositions and methods of purifying myelin-associated glycoprotein (mag): The present invention provides compositions and methods useful for purifying recombinant myelin-associated glycoprotein (MAG) and fragments thereof. In particular, the invention provides a one-step purification method for MAG and MAG fragments. Novel forms of human recombinant MAG protein are also disclosed in addition to methods of reliably producing and storing...

20060088916 - Il-17 homologous polypeptides and therapeutic uses thereof: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060088913 - Mutation associated with epilepsy: An isolated mammalian DNA molecule encoding a mutant γ-aminobutyric acid type A (GABAA) receptor subunit, wherein a mutation event selected from the group consisting of point mutations, deletions, insertions and rearrangements has occurred and said mutation event disrupts the functioning of an assembled GABAA receptor, or an otherwise functional fragment...

20060088908 - Mutiens of human neutrophil gelatinase-associated lipocalin and related proteins: Disclosed is a method for generating a mutein of a protein selected from the group consisting of human neutrophil gelatinase-associated lipocalin (hN-GAL), rat α2-microglobulin-related protein (A2m) and mouse 24p3/uterocalin (24p3), said mutein having detectable affinity to a given target. The method comprises the step of subjecting the protein to mutagenesis...

20060088907 - Novel 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245, 16228,...

20060088915 - Novel physiologically active peptide and use thereof: The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity...

20060088910 - Rt-pcr-based cloning of the human beta-amyloid precursor protein gene and the construction of its expression plasmids: Beta-amyloid peptide (βA) is a major fibrillar component of neuritic plaques in Alzheimer's disease brains and is related to the pathogenesis of the disease. βA generation depends on proteolytic cleavage of the amyloid precursor protein (APP). The present invention is a new procedure for the cloning of human βA precursor...

20060088914 - Ucp5: The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins (“UCPs”) and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous...

20060088909 - Virus-like particles, methods of preparation, and immunogenic compositions: Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of liciting an immune response using immunogenic compositions that include virus-like particles are described herein. A virus-like particle (VLP) can include a viral core protein that can self assemble into the VLP core...

20060088911 - Yeast transformation system: Disclosed are methods for obtaining expression of polypeptides in organisms employing alternative codon systems, and polynucleotides for use therein....

20060088917 - Il-17 homologous polypeptides and therapeutic uses thereof: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060088918 - Novel polyphosphate:amp phosphotransferase: (wherein NMP represents nucleoside monophosphate, NDP represents nucleoside diphosphate, dNMP represents deoxynucleoside monophosphate, dNDP represents deoxynucleoside diphosphate, n represents degree of polymerization of the polyphosphate which is an integer of up to 100); (B) substrate specificity: specific to AMP, GMP, IMP, dAMP, and dGMP, also acting with CMP, UMP, dCMP,...

20060088919 - Method for producing l-amino acids using bacteria of the enterobacteriaceae family: There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease....

20060088920 - Microbial production of coq10: The present Invention relates to enzymes involved in the Synthesis of Coenzyme Q-10, i.e., decaprenyl diphosphate (DPP) synthase and 4-hydroxybenzoate polyprenyltransferase, to isolated DNA encoding said enzymes and to methods for the microbial production of Coenzyme Q-10....

20060088921 - Production of biodegradable thermoplastic materials from organic wastes: A system and method for converting organic wastes to biodegradable thermoplastic materials including polyhydroxyalkanoates is disclosed, which method includes treating the organic wastes with an acidogenic microbial population to form fermentative organic acids, and polymerization of the organic acids by PHA-producing microbial species to form PHAs. The system includes a...

20060088922 - Lignin blockers and uses thereof: Disclosed is a method for converting cellulose in a lignocellulosic biomass. The method provides for a lignin-blocking polypeptide and/or protein treatment of high lignin solids. The treatment enhances cellulase availability in cellulose conversion and allows for the determination of optimized pretreatment conditions. Additionally, ethanol yields from a Simultaneous Saccharification and...

20060088923 - Enzyme granulate production method and resulting enzyme granulates: A method for producing enzyme granulates, the resulting enzyme granulates, and their use in formulations, e.g., for animal feed, food, washing means, rinsing means, and/or for pharmaceutical purposes and the like. The enzyme granulates show, in particular, a high relative percentage of active enzymes, certain grain sizes, good storage stability,...

20060088924 - Erk2 crystals: The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design....

20060088925 - Process for the intracellular over-production of streptokinase using genetically engineered strain of e.coli: An improved process for the production of streptokinase using a genetically engineered strain of Escherichia coli which overproduces streptokinase intracellularly and more particularly, the overall process disclosed herein, concerns with an improvement in the fermentative production of streptokinase using an optimized growth medium mainly comprised of simple salts and trace-elements;...

20060088926 - Method of removing hazardous substance, and hazardous substance removing material using the same such as air cleaning filter, mask and wipping sheet, and method of storing the same: A hazardous substance (20) is removed by using a hazardous substance removing material (10) in which a support (11) supports an antibody (12). Humidity of the ambient atmosphere of the antibody (12) is controlled so that the antibody (12) becomes active....

20060088927 - Method and apparatus for insulating body organs during transplantation: A method and apparatus for thermally affecting graft organs during harvesting and transplantation operations. An insulation jacket may be configured to conform to the shape of the graft organ. The insulation jacket may include a body portion constructed from a flexible surgical grade plastic, insulation foam, or thermo mass. The...

20060088928 - Method and apparatus for automatic staining of tissue samples: The present invention concerns an apparatus (1) for staining tissue samples, said apparatus (1) including a reagent section (2) or reagent containers (3); at least one staining section or tissue samples, a robotic head (22) or robotic element (20) that may move reagent to a predetermined tissue sample, said robotic...

20060088929 - Micro-reactor for gene inspection: After lysing a bacterial cell in the specimen by bacteriolysis reagent stored in bacteriolysis reagent storage section 3, and after adsorbing bacterial genes on carriers filled in carrier filling section 4, there is conducted preliminary processing for washing and detecting bacterial genes. Further, there are provided a control means that...

20060088930 - Reduced aperture biological specimen collection and transfer device: A filtration based biological specimen collection and transfer device is provided. The filtration and transfer device comprises a tubular body with two axial ends, an annular flange disposed at one of the axial ends, and a biological specimen filter affixed to the outer surface of the annular flange. Preferably, the...

20060088931 - Thermal cycling system and vessel therefor: Flexible vessels for thermal cycling a sample are provided, the flexible vessels comprising a flexible body having first and second portions coupled together and in fluid communication with each other, wherein the flexible body is configured for insertion into a thermal cycler such that the first portion is received into...

20060088932 - Gsk3 polypeptides: The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of...

20060088933 - Reagents for detecting efavirenz: The invention provides derivatives of efavirenz and methods of making derivatives of efavirenz. The derivatives include immunogenic compounds for producing antibodies to efavirenz and labeled efavirenz tracers. These compounds are useful in immunoassay methods for determining efavirenz....

20060088934 - Methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of the transcription factor atf5: The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem/progenitor cells, for producing differentiated cells and for isolating/purifying differentiated cells, including neural...

20060088935 - Method of ex vitro sowing, germination, growth and conversion of plant somatic embryos or germinants, and nutrient medium used therefor: A method of sowing a somatic plant embryo or germinant of a conifer species to facilitate subsequent development of the embryo or germinant into an autotrophic seedling. The method involves the following steps carried out ex vitro in non-sterile conditions: providing a nutrient medium comprising particles of a solid component...

20060088937 - Flavivirus expression and delivery system: The present invention provides a gene expression system comprising: a) a self-replicating expression vector of flavivirus origin which includes the flavivirus 5′ untranslated region (UTR), at least a portion of the 5′ coding region for flavivirus core protein, the nucleotide sequence coding for the flavivirus non-structural proteins, and the complete...

20060088936 - Raav expression systems for genetic modification of specific capsid proteins: Disclosed are improved recombinant adeno-associated viral (rAAV) vectors having mutations in one or more capsid proteins. Exemplary vectors are provided that have altered affinity for heparin or heparin sulfate, as well as vectors, expression systems, and rAAV virions that lack functional VP2 protein expression, but are nevertheless, fully virulent. Also...

20060088938 - Methods and compositions for use in spliceosome mediated rna trans-splicing in plants: The molecules and methods of the present invention provide a means for in vivo production of a trans-spliced molecule in a selected subset of cells. The pre-trans-splicing molecules of the invention are substrates for a trans-splicing reaction between the pre-trans-splicing molecules and a pre-mRNA which is uniquely expressed in the...

20060084051 - Grid etcher: An apparatus and process for monitoring migratory cell proliferation with restricted migration on a substrate includes providing a substrate, coating the substrate with extracellular matrix, plating cells suspended in cell culture media on extracellular matrix, and placing intersecting channels across the extracellular matrix components by removing the extracellular matrix components...

20060084052 - Detection of viable agents: A quantitative PCR method has been developed for the simultaneous detection and quantitation of an agent in samples of biologically derived materials. Unlike conventional quantitative PCR detection methods, this assay allows for the detection of viable agents....

20060084082 - 186 human secreted proteins: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing...

20060084105 - Arrays for detection of products of mrna splicing: The invention features an array comprising at least one set of nucleic acid probes for detection of gene products that are produced by mRNA splicing of a selected gene, wherein each probe set is specific for a selected gene, and wherein the probe set minimally comprises a splice junction probe...

20060084096 - Biomarkers and expression profiles for toxicology: The present invention is based on the determination of the global changes in gene expression in tissues or cells exposed to known toxins, in particular hepatotoxins, as compared to unexposed tissues or cells as well as the identification of individual genes that are differentially expressed upon toxin exposure. The invention...

20060084055 - Compositions and methods for the detection diagnosis and therapy of hematological malignancies: Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an...

20060084087 - Compositions and methods for treating episodic movement disorders and related conditions: The present invention provides compositions and methods for research, diagnostic, drug screening, and therapeutic applications related to paroxysmal dystonic choreoathetosis and related conditions. In particular, the present invention provides mutations in the myofibrillogenesis regulator 1 (MR-1) gene associated with such conditions....

20060084095 - Compositions, methods, and systems for determining bovine parentage and identity: Provided herein are methods to discover and use single nucleotide polymorphisms (SNP) for identifying parentage or identity of a bovine subject. The present invention further provides specific nucleic acid sequences, SNPs, and SNP patterns that can be used for identifying parentage of various breeds of cattle including Angus, Holstein, Limousin,...

20060084094 - Conjugates for use in hepatocyte free uptake assays: The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits....

20060084053 - De novo dna cytosine methyltransferase genes, polypeptides and uses thereof: De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine methyltransferase polynucleotides and polypeptides in diagnostic assays, for an in vitro DNA methylation application and therapeutic applications such as the treatment of neoplastic disorders....

20060084108 - Dna binding protein: Methods of screening for compounds which are, for example, capable of modulating amino acid-DNA interaction, modulating DNA replication, modulating cell proliferation, and for identifying compounds which inhibit cellular proliferation caused by cancer, are provided....

20060084071 - Drug targets for the treatment of neurodegenerative disorders: Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are...

20060084072 - Drug targets for the treatment of neurodegenerative disorders: Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are...

20060084064 - Endocan compositions and methods for the treatment of neoplasms: The present invention features improved diagnostic and therapeutic methods for neoplasia treatment relating to endocan nucleic acid molecules and polypeptides. In addition, the invention features methods for monitoring the responsive of a tumor in a patient to therapy; methods for suppressing the growth of a neoplasm by inhibiting endocan expression...

20060084060 - Gel having biosubstance fixed thereto and microarray utilizing the gel: The present invention provides a biological substance-immobilized gel which comprises a gel containing 2%-7% by mass of N,N-dimethylacrylamide and a biological substance immobilized on and/or in the gel....

20060084092 - Homogeneous assay system: A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay....

20060084100 - Information nucleic acid and information nucleic acid composition using the same: An information nucleic acid includes a base sequence portion having an arbitrary and known base sequence. The information nucleic acid is mixed with an additive such as a fat solubilizing agent, a heat stabilizer, a light stabilizer, a nucleic acid hydrolase inhibitor and/or a dispersing agent so as to form...

20060084069 - Integrated circuit optical detector for biological detection: This invention provides an integrated circuit (IC) optical detector. The IC optical detector comprises a substrate and an IC. The substrate comprises a plurality of test sites defined thereon. The test sites comprise a surface suitably treated for coating of at least one test sample. The at least one test...

20060084067 - Method and system for analysis of array-based, comparative-hybridization data: Embodiments of the present invention include methods and systems for analysis of comparative genomic hybridization (“CGH”) data, including CGH data obtained from microarray experiments. Various embodiments of the present invention include parametric and non-parametric normalization methods for CGH data, methods for identifying sets of one or more contiguous chromosomal DNA...

20060084111 - Method for gene identification signature (gis) analysis: An isolated oligonucleotide comprising at least one ditag, wherein the ditag comprises two joined first and second sequence tags, wherein the first tag comprises the 5′-terminus sequence and the second tag comprises the 3′-terminus sequence of a nucleic acid molecule or a fragment thereof. The ditag analysis is useful for...

20060084076 - Method for the amplification of genetic information: The invention relates to a method for the amplification of genetic information, wherein it is possible to analyze the frequency of unlimited partial amounts of genetic material from very small sample amounts. The inventive methods enable parallel amplification of specific target sequences of the respective partial amounts and simultaneous qualitative...

20060084078 - Method of identifying active chromatin domains: The invention provides a method of mapping DNA-protein interactions within a genome by fixing living cells to cross-link DNA and proteins, lysing the cells, and isolating chromatin by immunoprecipitation. DNA is purified and a SAGE protocol is performed on the purified DNA to produce GMAT-tag sequences, which are compared to...

20060084083 - Method to generate or determine nucleic acid tags corresponding to the terminal ends of dna molecules using sequences analysis of gene expression (terminal sage): A method of providing an indication of an instance of expression of a gene is described herein, the method which may comprise the steps of: (a) providing a complementary deoxyribonucleic acid (cDNA) having a terminus comprising a terminal transcribed sequence of a gene; (b) linking the cDNA to an linker...

20060084085 - Methods and compositions for modulating bax-mediated apoptosis: Provided herein are methods and compositions for modulating apoptosis of cells and the lifespan of cells. These may be used for treating or preventing aging-related disorders and cancer....

20060084091 - Methods and compositions for polypeptide engineering: Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed....

20060084070 - Methods and compositions for predicting drug responses: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene....

20060084081 - Methods and compositions for predicting drug responses: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on the level of expression of the VKORC1 gene....

20060084077 - Methods and devices for identifying terrorists/criminal suspects by detecting contact of human skin with rubber protective gear: The present invention relates to devices and methods for detecting a contaminant on a surface, particularly detecting dithiocarbamates on human skin. The devices and methods are further used to identify a suspect or to conduct forensic analysis of a suspect to determine if they have come into contact with protective...

20060084080 - Methods and kits for the selection of animals having certain milk production capabilities, based on the analysis of a polymorphism in the somatotropin receptor gene: The present invention relates to a genetic marker used to distinguish amongst animals a trait for milk producing capabilities and milk composition. The marker is a mutation in the gene encoding somatotropine (also called growth hormone)-receptor (GH-R) at amino acid position 279 (a phenylalanine to tyrosine substitution in the transmembrane...

20060084061 - Methods for blocking adipocyte differentiation and triglyceride accumulation with interleukin 12 p35 inhibitors: Methods for blocking adipocyte differentiation and triglyceride accumulation with inhibitors of Interleukin 12 p35 and provided. Interleukin 12 p35 inhibitors of the present invention include small molecules, antibodies, peptides (including dominant negative peptides) and antisense compounds, including ribozymes, inhibitory RNA molecules including siRNA molecules and antisense oligonucleotides....

20060084102 - Methods for determining precise herg interactions by mutagenesis: The present invention discloses methods of determining highly precise interactions between the HERG ion channel and various compounds. The methods of the present invention utilize modified HERG ion channels combined with heterologous in vivo expression in Xenopus oocytes and mammalian cells....

20060084056 - Methods for selecting treatment regimens and predicting outcomes in cancer patients: The present invention relates to methods for determining a treatment regimen beyond surgical removal of tumor tissue for node negative or node positive breast cancer patient. The method comprises measuring the levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in a subject, preferably a tumor; and, based...

20060084104 - Methods for the detection of kidney cancer: Methods for the detection of kidney cancer are disclosed....

20060084057 - Methods of diagnosing liver fibrosis: The present invention provides a method of diagnosing the presence or severity of liver fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of a metalloproteinases-1 (TIMP-1) in a sample from the individual;...

20060084107 - Methods of treating skin conditions using inhibitors of the cd2/lfa-3 interaction: Methods of using inhibitors of the CD2/LFA-3 interaction-in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in mammals, including humans. Such conditions include psoriasis, UV damage, e.g., photoaging, atopic dermatitis, cutaneous T cell lymphoma such as mycosis fungoides, allergic and...

20060084110 - Methods to identify plant metabolites: This invention provides materials and methods to manipulate the plant genome at the level of single plant cells in culture resulting in the ability to assign metabolic functionality to plant genes involved in the production of biologically active molecules and to create a means of product discovery based on the...

20060084106 - Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions: An improved microfabricated apparatus for conducting a multiplicity of individual and simultaneous binding reactions is described. The apparatus comprises a substrate on which are located discrete and isolated sites for binding reactions. The apparatus is characterized by discrete and isolated regions that extend through said substrate and terminate on a...

20060084098 - Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes: The present disclosure concerns methods and compositions relating to mixed-library parallel gene trait mapping. In particular embodiments, the methods concern quantitative microarray hybridization techniques for genome-wide identification of trait conferring genes. In other embodiments, the compositions concern genetic elements that confer or are associated with a trait. In an exemplary...

20060084079 - Modified oligonucleotides and applications thereof: Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof....

20060084090 - Modulation of interaction between nod1 and gram-negative bacteria by nod1 response to peptidoglycan delivered by the helicobacter pylori cag pathogenicity island (cagpai): A method for identifying a compound that modulates the interaction between Nod1 and a Gram-negative bacteria comprising contacting a Nod1 expressing cell with a cagPAI-positive H. pylori in the presence of a compound, contacting a Nod1 expressing cell with a cagPAI-positive H. pylori in the absence of said compound, and...

20060084097 - Modulation of nitric oxide signaling through signaling through specific regulation by arginylation and the n-end rule pathway: Screening assays that allow for the identification of agents that modulate the activity of the arginylation branch of the N-end rule pathway are provided. Also provided are method of using an agent that modulate the activity of the arginylation branch of the N-end rule pathway to increase or decrease protein...

20060084054 - Novel proteins and nucleic acids encoding same: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule...

20060084073 - Nucleic acids encoding human tbc-1 protein and polymorphic markers thereof: The invention concerns genomic and cDNA sequences of the human TBC-1 gene. The invention also concerns polypeptides encoded by the TBC-1 gene. The invention also deals with antibodies directed specifically against such polypeptides that are useful as diagnostic reagents. The invention further encompasses biallelic markers of the TBC-1 gene useful...

20060084093 - Packaging cells comprising codon-optimized gagpol sequences and lacking lentiviral accessory proteins: Novel packaging cell lines useful for generating viral accessory protein independent HIV-derived retroviral vector particles, methods of constructing such packaging cell lines and methods of using the viral accessory protein independent HIV-derived retroviral vector particles are disclosed....

20060084068 - Process for detecting a nucleic acid target: Described is a process for detecting the presence or absence of one or more target nucleotides. A primer is added to a solution containing DNA. The solution is put under conditions favorable to PCR amplification using sequence specific primers. Product is then measured to determine the presence or absence of...

20060084099 - Product identification method: A product identification method of one embodiment of the invention includes the steps of providing a product with an information nucleic acid having a segment of known base sequence randomly selected for the product, extracting the information nucleic acid from the product, amplifying the information nucleic acid by a polymerase...

20060084075 - Program for analysis of the time-series data obtained by dna array method, a method for analysis of the time-series data obtained by dna array method, and a device for analysis of the time-series data obtained by dna array method: According to this invention, a program for analysis of the time-series data obtained by DNA array method is provided, the program instructing a computer to execute a function to arrange numerical data representing the expression of genes obtained by DNA array method to a database in order of time-series, and...

20060084086 - Proteins, polynucleotides encoding them and methods of using the same: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research...

20060084103 - Pseudo-tissue for quality control and quality control method using same: A pseudo-tissue for quality control is described, which includes a nucleic acid component selected from the group consisting of a nucleic acid and a cell including a nucleic acid, and a gel for holding nucleic acid component....

20060084062 - Purification, cloning and biochemical characterization of xendou, endoribonucleasic activity involved in small nuclear rna splicing-independent biosynthesis in xenopus laevis: Cloning and characterization of the gene for Mn++ dependent RNA-sc endoribonucleasic activity able to generate 2′-3′ cyclic phosphate and 5′OH ends....

20060084063 - Rabs as modifiers of the p53 pathway and methods of use: Human RAB genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of RAB are provided....

20060084065 - Radioactive multiplexing analytical methods for biomarkers discovery: A novel analytical method involves labeling samples with different radioactive labeling agents, mixing and subjecting the mixture to any separation technique, and then differentially detecting and quantifying subcomponents from each sample for comparison. The novel technique exploits the differences in radiation energy or half-life between isotopes to make differential detection...

20060084109 - Regulated aptamer therapeutics: Materials and methods of use thereof are presented for the treatment of diabetes and other diseases. Therapeutic compositions including regulated aptamer therapeutic compositions with specificity to components of diabetes disease are presented with methods of administering these therapeutic compositions....

20060084084 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060084059 - Serum biomarkers in hepatocellular carcinoma: Certain biomarkers and biomarker combinations are useful in a qualifying hepatocellular carcinoma status in a patient. A diagnostic methodology employing these biomarkers and combinations can distinguish between hepatocellular carcinoma and chronic liver disease, for example....

20060084058 - Substrates for hybridization and method of using the same: A hybridization substrate having on a substrate surface thereof a branching nucleic acid strand comprising a principal strand of nucleic acid a portion of which is attached to the surface of the substrate and a portion of which is single-stranded, and a strand of single-stranded nucleic acid for probe that...

20060084066 - Surrogate markers of neuropathic pain: The disclosure provides methods and compositions for the evaluation of neuropathic pain and neurotrophic or other activity of a drug or drug candidate. In the disclosed methods, expression of certain gene(s) in tissue extracts from skin biopsies serves as a proxy of a relevant endpoint....

20060084088 - Tracking biological samples and their processing history: Biological samples undergo drastic changes during the execution of an experiment to aid in the determination of gene discovery, disease diagnosis, drug discovery, toxicological research, and so on. After a biological sample is processed, pieces of information about the state of a biological sample are generated. Pedigree information is also...

20060084101 - Two-color chemiluminescent microarray system: Methods, apparatus and systems for detecting target molecules in samples are provided....

20060084089 - Use of magnetic material to direct isolation of compounds and fractionation of multipart samples: Methods for isolating a compound from a multipart, typically biological sample. The methods use at least one paramagnetic particle having an associated electronic charge to bind compounds with the opposite charge to form a particle/compound complex. Alternatively, the paramagnetic particles have a ligand or functional group with an affinity for...

20060084074 - Use of whole blood in pcr reactions: A method of obtaining DNA amplification of a nucleic acid target from a volume of whole blood comprising performing DNA amplification in a PCR assay mixture with a blood-resistant polymerase....

20060084116 - Analysis of mhc-peptide binding interactions: Methods, apparatuses, and compounds for screening or detecting binding of candidate peptides to an MHC construct is provided. A first component including at least one candidate peptides and a second component including at least one MHC construct are contacted. One of the components is immobilized on a solid support. The...

20060084112 - Apolipoprotein biopolymer marker indicative of normal human: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their...

20060084113 - Directed evolution of disulfide-bonded micro-proteins: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore...

20060084117 - Galphaq protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors: The invention provides a series of Gαq protein variants that functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory GPCRs (ORs) in an overly promiscuous manner. According to the invention, the functional coupling can be determined, for example, by measuring changes in intracellular IP3, or calcium....

20060084114 - Method for detecting cardiac collateral formation: The present invention relates to a method of detecting collateral artery formation by measuring the level of NT-pro-BNP or BNP in an individual....

20060084115 - Selective high affinity polydentate ligands and methods of making such: This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or...

20060084118 - T-bet compositions and methods of use thereof: Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a T-bet transgene. The...

20060084119 - Method of screening transporter inhibitor: Methods for measuring transporter activity using budding baculoviruses that do not express endogenous transporters on their envelope have a low background level and can measure the target activity with a high sensitivity. Such methods can be used to measure functional changes due to transporter SNPs over a more extensive range...

20060084120 - Methods and compositions for modulating hepatocyte growth factor activation: The invention provides methods and compositions for modulating hepsin activity and the HGF/c-met signaling pathway, in particular by regulating pro-HGF activation by hepsin....

20060084121 - Ox2 receptor homologs: Nucleic acids encoding mammalian, e.g., primate, receptors, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described....

20060084124 - Localization of a2b ador on human normal and diseased tissue: the use of anti-a2b antibody to diagnose and treat human tumors: The invention provides methods of detection, prevention, amelioration, and treatment for angiogenesis, including angiogenesis associated with colon cancer and glioma. The methods comprise the use of an anti-A2B antibody....

20060084122 - Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor: The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome, a method of diagnosing delayed engraftment of the hematopoietic stem cells after transplantation...

20060084125 - Methods, devices, and systems for detection of cancer: Disclosed are methods, devices, and systems for early detection of cancer. The cancer may be a glandular cancer, such as breast