Chemistry: molecular biology and microbiology inventions 04/06

20060088814 - Enhanced cell preservative solution and methods for using same: The present invention relates to an aqueous alcohol buffer solution for substantially ambient, in vitro preservation of mammalian cells for a selected duration....

20060088813 - Glyoxal/zinc fixative: This invention provides compositions and methods for fixing a biological sample, particularly fecal samples for diagnosis of parasitic infection. The fixative composition of the present invention comprises glyoxal (pyruvate aldehyde) and zinc sulfate and permits staining of biological samples without use of toxic compounds, such as formaldehyde and mercury-containing compounds....

20060088816 - Detection of transmembrane potentials using n,n,n'-trialkyl thiobarbituric acid-derived polymethine oxonols: i

20060088815 - Method for evaluation of endocrine disruptive action: There is provided a method for a quick and easy evaluation of a substance which is an object of evaluation for its endocrine disruptive action. An evaluating method according to the present invention is a method for the evaluation of endocrine disruptive action which is characterized in comprising a step...

20060088817 - Method of determining plant species with pyrolysis-gas chromatography: A method of identifying a plant species includes the steps of: preparing a fragment of the plant; heating the fragment to obtain lignin from the fragment; gasifying the lignin at a high temperature to obtain components of the lignin; obtaining a flux profile of the components; and determining the species...

20060088820 - Detecting superantigen activity in a biological sample: Multiple sclerosis or a condition associated with multiple sclerosis is detected by detecting an amount of lymphocytes bearing a Vβ16, Vβ17 or Vβ7 determinant and calculating an amount of expansion or loss of these lymphocytes....

20060088818 - Optical detection of microorganisms and toxins: A method of detecting the presence of selected microorganisms within a fluid includes filtering the fluid to remove large particles prior to analyzing the fluid with an antibody matrix. Non-specific binding is eliminated by washing and the presence of biological material is detected. If biological material is detected within the...

20060088819 - Truncated hepatitis c virus ns5 domain and fusion proteins comprising same: The invention provides truncated HCV NS5 polypeptides and fusion proteins comprising the truncated NS5 polypeptides, fused to at least one other HCV epitope derived from another region of the HCV polyprotein. The fusions can be used in methods of stimulating an immune response to HCV, for example a cellular immune...

20060088872 - Allele-specific mutation detection assay: The present invention relates to a method of detecting a base at a pre-determined position in a nucleic acid molecule by performing enzymatic detection reactions using base-specific detection oligomers, where each oligomer is specific for a particular base at the predetermined position, and then comparing the enzymatic detection reactions to...

20060088864 - Aptamer regulated nucleic acids and uses thereof: The invention relates to trans-acting ligand-responsive nucleic acids and uses thereof. In particular, a ligand responsive nucleic acid comprises an effector domain and an aptamer domain that is responsive to a ligand....

20060088847 - Arf-bp1 as mediator of p53-dependent and independent tumor suppression and uses thereof: The present invention relates to the mechanism of ARF-mediated cell growth suppression. ARF-BP1 is identified as a novel ubiquitin ligase, and a major component of ARF-containing nuclear complexes in human cells. The present invention discloses a novel mechanism of ARF-mediated p53 activation and that ARF-BP1 is a critical mediator of...

20060088863 - Automated method of manufacturing polyer arrays: The present invention provides methods to process multiple sensors by providing a sensor plate and HT plates. In a preferred embodiment of the invention, methods for assembling microarray pegs and microarray plates are described for high throughput microarray processing....

20060088849 - Compositions and methods for the diagnosis of group b streptococcus infection: The present invention relates to methods of detecting a Group B Streptococcus (GBS) bacterium in a sample. In particular, the present invention provides compositions, kits and methods for detecting the gbs1539 gene of a GBS bacterium....

20060088821 - Construction and use of catalogued nucleic acid libraries that contain advantageously adjusted representations of defined components: A process for constructing a catalogued nucleic acid library in which the proportional representation of the constituents is adjusted to advantage through the use of disclosed technologies for positive and negative selection. The resultant benefit is that significantly fewer library constituents will need to be screened in order to identify...

20060088833 - Detection of mycobacteria in clinical material: The present invention relates to a molecular biological method for the specific detection of mycobacteria and for the differentiation of the Mycobacterium tuberculosis complex and Mycobacterium avium from other mycobacteria in clinical material by means of amplification primers and oligonucleotide probes which are specific for the genus- and species-specific regions...

20060088827 - Diagnostic and therapeutic use of a voltage-gated ion channel scn2a for neurodegenerative diseases: The present invention discloses the differential expression of the gene coding for the voltage-gated ion channel SCN2A in specific brain regions of Alzheimers disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer s disease, in a subject, or...

20060088826 - Discrimination and detection of target nucleotide sequences using mass spectrometry: A method for determining the presence or absence of at least one target sequence in a nucleic acid sample, comprising the steps of performing an oligonucleotide ligation assay, digesting the resulting amplified probes with a restriction enzyme isolating detectable fragments and the determining the presence of detectable fragments by mass...

20060088879 - Dna polymerases having improved labeled nucleotide incorporation properties: The present invention relates to mutant DNA polymerases that exhibit reduced discrimination against labeled nucleotides into polynucleotides. The DNA polymerases of the invention have at least one mutation in the nucleotide label interaction region of the enzyme such the mutation results in reduced discrimination against labeled nucleotides. The nucleotide label...

20060088862 - Drug screening and molecular diagnostic test for early detection of colorectal cancer: reagents, methods, and kits thereof: A novel approach to the early detection of colorectal cancer (“CRC”), using a molecular diagnostic test to evaluate grossly normal-appearing colonic tissue for the early detection of colorectal cancer is disclosed. Such grossly normal-appearing colonic mucosal cells may be collected from non-invasive or minimally invasive procedures. The use of novel...

20060088856 - Dual labeled fluorescent probes: The present invention relates to probes useful for the detection and measurement of target nucleic acids, as well as compositions and kits containing such probes. The probes of the present invention include an interactive pair of labels, as well as a hairpin sequence that does not hybridize to a target...

20060088871 - Dynamic genomic deletion expansion and formulation of molecular marker panels for integrated molecular pathology diagnosis and characterization of tissue, cellular fluid, and pure fluid specimens: Provided are materials, methods, platforms, and kits for diagnosing, prognosing, and/or determining the biological aggressiveness of a tumor (malignant and non-malignant) based in part on the temporal profile of genomic deletion expansion of the tumor. Also provided are methods of determining marker panels for different diseases and/or tissues and markers...

20060088837 - Expression system for stem-loop rna molecule having rnai effect: The present inventors discovered that an RNA molecule can be efficiently transferred into cytoplasm and exert RNAi effects, by producing a stem loop RNA molecule from the DNA that encodes this RNA molecule, with the use of a tRNA promoter. Also, the RNAi effects can be exerted effectively, by introducing...

20060088825 - Human delta-n p73 molecules and uses thereof: The present invention is in the field of molecular biology and genetics. More specifically, the invention relates to human ΔN p73, a novel gene associated with apoptosis regulation. The present invention provides and includes nucleic acid molecules, proteins and antibodies associated with ΔN p73 and methods utilizing such agents, for...

20060088861 - Information nucleic acid-carrying fine particles and production method thereof: Information nucleic acid-carrying fine particles to be used for individuality authentication for industrial products. The information nucleic acid-carrying fine particles include fine particles on which an information nucleic acid including a base sequence portion having an arbitrary and known base sequence is carried....

20060088851 - Invasion/migration gene: This invention relates to the detection of increased expression from the HoxB13 (homeobox B13) gene as indicative of an invasive or metastatic cancer phenotype. The invention provides methods of detecting the level of expression from the HoxB13 gene, optionally in combination with nodal status, as an indicator of the invasive...

20060088834 - Matrix analysis of gene expression in cells (magec): The invention provides a novel expression cloning technique referred to as a matrix analysis of gene expression in cells (MAGEC) that allows for the indexed introduction, and analysis of nucleic acids in a host cell. While normally one takes cells attached to a surface followed by contacting the cells with...

20060088875 - Means for electrical contacting or isolation of organic or inorganic semiconductors and a method for its fabrication: In a means for electrical contacting or isolation of organic or inorganic semiconductors in electronic and optoelectronic devices, particularly thin-film devices, the means comprises a substrate (1) in the form of a contact material (1a) or an isolating material (4). A charge transfer material (2) is provided patterned or unpatterned...

20060088860 - Metabolite markers for weight management: The present invention provides methods of using certain metabolite markers for predicting weight development or its related conditions of a subject. The present invention also provides compositions and kits useful for detecting metabolite markers of the present invention....

20060088845 - Method and apparatus for analyzing and generating human antibody amino acid and nucleic acid sequences: The invention provides methods, computer programs, data and databases, computer readable media, computer systems, and/or apparatus that use, compare or generate data corresponding to at least one partial antibody or antibody fusion protein nucleic acid or amino acid sequence, on recordable media or in computer memory, such as engineered antibody...

20060088840 - Method for analyzing body fluids for the presence of cancer cells, use thereof, corresponding analysis kits, and use of specific active substances for treating cancer: The present invention relates to a method for investigating body fluids for cancer cells, the use thereof and corresponding analysis kits, and the possibilities for cancer treatment derived therefrom. The method is based essentially on determining the expression of the manganese superoxide dismutase, thioredoxin reductase and/or glutathione peroxidase genes. Use...

20060088852 - Method for determining the homeostasis of hairy skin: The invention relates to a method for determining the homeostasis of hairy skin in vitro, to test kits and biochips for determining markers of hairy skin, in addition to the use of proteins, mRNA molecules or fragments thereof as markers of hairy skin. The invention also relates to a test...

20060088850 - Method for genome-wide analysis of palindrome formation and uses thereof: The present invention provides a method for rapidly detecting the genome-wide presence of palindrome formation. The method has demonstrated that somatic palindromes occur frequently and are widespread in human cancers. Individual tumor types have a characteristic non-random distribution of palindromes in their genome and a small subset of the palindromic...

20060088857 - Method for isolation of independent, parallel chemical micro-reactions using a porous filter: The present invention relates to methods and apparatuses for conducting densely packed, independent chemical reactions in parallel in fluid-permeable arrays. Accordingly, this invention also focuses on the use of such arrays for applications such as DNA sequencing, most preferably pyrophosphate sequencing, and DNA amplification....

20060088848 - Method for patterning large scale nano-fibrous surfaces using capillography: A method of assembling large numbers of nanoscale structures in pre-determined ways using fluids or capillary lithography to control the patterning and arrangement of the individual nanoscale objects and nanostructures formed in accordance with the inventive method are provided. In summary, the current method uses the controlled dispersion and evaporation...

20060088876 - Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the do: A method for the early diagnosis of breast, lung, pancreatic and colon growths and cancers as well as conditions associated with donor and recipient organ transplants, both before and after transplantation to identify and allow treatment of possible transplanted organ rejection and other disease conditions related and unrelated to the...

20060088839 - Method of detecting nucleic acid by using dna microarrays and nucleic acid detection apparatus: A nucleic acid contained in a sample is quantified with high accuracy. The procedure includes the step of allowing the sample containing a specific nucleic acid to interact with a DNA microarray provided with a plurality of nucleic acid probe parts having a nucleic acid probe capable of hybridizing to...

20060088836 - Methods and compositions for diagnosing and monitoring transplant rejection: Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also...

20060088880 - Methods and compositions for the treatment and diagnosis of cellular proliferation disorders using 25943: The present invention relates to methods and compositions for the treatment and diagnosis of cellular proliferation disorders, including, but not limited to, breast cancer, ovarian cancer, lung cancer, and colon cancer. The invention further provides methods for identifying a compound capable of treating a cellular proliferation disorders disorder or modulating...

20060088881 - Methods and compositions for treating urological disorders using 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 or 6351 molecules: The present invention relates to methods for the diagnosis and treatment of a urological disorder or urological disorders. Specifically, the present invention identifies the differential expression of 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 and 6351...

20060088865 - Methods and compositions related thereto for detecting and identifying distinct species of nucleic acids from causative agents: Methods are described herein for detecting and identifying distinct species of nucleic acids, in a single container, for example, from a certain genus of infectious agents or otherwise causative agents comprising, for example, providing a forward PCR primer common to a homologous gene region between the distinct species, and providing...

20060088874 - Methods and kits for detecting mutations: Disclosed are, methods and kits for detecting mutations in DNA by comparing the size of an amplified microsatellite locus to the expected size. The methods and kits may used in various applications, including monitoring exposure of a cell or organism to a mutagen, evaluating the mutagenicity of an agent, and...

20060088831 - Methods for identifying large subsets of differentially expressed genes based on multivariate microarray data analysis: The present invention provides multivariate methods for identifying differentially expressed genes based on microarray expression data. An improved random search procedure involving certain probability distances is provided. The methods of this invention implement a successive elimination procedure to remove smaller subsets resulted from each step of the random search thereby...

20060088838 - Methods for improving a binding characteristic of a molecule: The present invention relates to methods for improving a binding characteristic of a molecule, e.g., a peptide, for a binding target, in which the molecule is covalently linked to a detectable moiety, e.g., an enzyme, or an active portion or derivative thereof. The present invention also relates to molecules produced...

20060088873 - Methods for smn genes and spinal muscular atrophy carriers screening: A method for SMN genes identifying is disclosed, as well as a method for spinal muscular atrophy carriers screening. The method comprises steps of following: (a) providing a genomic DNA; (b) amplifying the genomic DNA with a pair of primers; and (c) injecting the amplified product into DHPLC (Denaturing High...

20060088855 - Methods of using fet labeled oligonucleotides that include a 3'-5' exonuclease resistant quencher domain and compositions for practicing the same: Methods and compositions are provided for detecting a primer extension product in a reaction mixture. In the subject methods, a primer extension reaction is conducted in the presence of a polymerase having 3′→5′ exonuclease activity and at least one FET labeled oligonucleotide probe that includes a 3′→5′ exonuclease resistant quencher...

20060088846 - Methods to identify compounds useful for the treatment of proliferative and differentiative disorders: The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: FBP1, FBP2, FBP3, FBP4, FBP5, FBP6, FBP7, FBP8, FBP9, FBP10, FBP11, FBP12, FBP13, FBP14, FBP15, FBP16, FBP17, FBP18,...

20060088823 - Microarray gene expression profiling in clear cell renal cell carcinoma : prognosis and drug target identification: A nucleic acid probe or a novel set of such probes in a microarray is provided. The probe or probe set is useful in the prognosis of patients with clear cell renal cell carcinoma (CC-RCC), wherein aggressive and non-agressive CC-RCC tumor types are characterized by differential expression profiles of genes...

20060088829 - Minrs as modifiers of insulin receptor signaling and methods of use: Human MINR genes are identified as modulators of INR signaling and thus are therapeutic targets for disorders associated with defective INR signaling. Methods for identifying modulators of MINR, comprising screening for agents that modulate the activity of MINR are provided....

20060088843 - Modified venom and venom components as anti-retroviral agents: The present invention relates to a class of proteins, a process of production thereof, and a method for treatment of neurological and viral diseases in humans and animals. More specifically it applies to the treatment of heretofore intractable diseases such as retro-viral infections including human immunodeficiency virus (HIV), simian immunodeficiency...

20060088858 - Modified venom and venom components as anti-retroviral agents: The present invention relates to a class of proteins, and a method for treatment of neurological and viral diseases in humans and animals. More specifically it applies to the treatment of heretofore intractable diseases such as retro-viral infections including human immunodeficiency virus (HIV), simian immunodeficiency virus (SIV), feline immunodeficiency virus...

20060088822 - Novel polymerase compositions and uses thereof: The subject invention provides novel compositions containing a mixture of (a) an enzyme that possesses substantial 3′-5′ exonuclease activity (b) a DNA polymerase with less 3′-5′ exonuclease activity than the enzyme with substantial 3′-5′ exonuclease activity. Preferably, the DNA polymerase for inclusion in the compositions are DNA polymerases that substantially...

20060088828 - Polycystic kidney disease nucleic acids and proteins: Nucleic acids and polypeptides are provided that are associated with autosomal recessive polycystic kidney disease. Antibodies against the polypeptides, vectors and host cells containing the nucleic acids, methods for using the nucleic acids, and compositions and articles of manufacture also are provided....

20060088830 - Protein biomarkers that distinguish prostate cancer from non-malignant cells: This invention provides organic biomolecule markers (e.g., proteins) useful for differentiating prostate cancer, prostate intraepithelial neoplasia or benign prostate hyperplasia, from a negative diagnosis (i.e. normal and benign prostate epithelial cells)....

20060088867 - Purification devices comprising immobilized capture probes and uses therefor: The present invention pertains to devices comprising at least one purification unit, used to purify and/or concentrate a target molecule contained within a test sample. Typically, the target molecule in a test sample will be a nucleic acid. These purified nucleic acids can be used in a variety of ways,...

20060088878 - Purification of recombinant proteins fused to multiple epitopes: The present invention provides novel identification polypeptides containing multiple copies of an antigenic domain joined in tandem to provide increased sensitivity for the detection and purification of target peptides, a cleavable linking sequence and optionally a spacer domain. Further provided are hybrid polypeptide molecules composed of an identification polypeptide and...

20060088866 - Quantitative methylation detection in dna samples: Described is a method for methylation detection in a DNA sample. An isolated genomic DNA sample is treated in a manner capable of distinguishing methylated from unmethylated cytosine bases. The pretreated DNA is amplified using at least one oligonucleotide primer, a polymerase and a set of nucleotides of which at...

20060088844 - Real-time pcr microarray based on evanescent wave biosensor: A system and method for simultaneous, quantitative measurement of nucleic acids in a sample. Fluorescently tagged amplicons of the target nucleic acids are localized on a substrate surface by hybridization to oligopobes that have been arrayed and tethered to the substrate surface in a pre-determined, two-dimensional pattern. The hybridized, amplicons...

20060088868 - Repair of nucleic acids for improved amplification: Methods and compositions are provided for repairing a polynucleotide so that it can be synthesized efficiently with improved fidelity and yield in, for example, an amplification reaction. This involves the use of a reaction mixture that includes a ligase and a cofactor selected from NAD+ or ATP and incubating the...

20060088859 - Reporter assay screens for protein targets in saccharomyces cerevisiae: The present invention comprises responsive promoters along with screening methods which make use of the promoters in order to identify anti-fungal substances....

20060088841 - Reversible, parallel and multitask cloning method and kit: The present invention is related to a reversible, parallel and/or multitask cloning method and kit, which improve the cloning of (preferably multiple) genetic element(s) in a nucleic acid construct such as vector or in chromosome of a cell and the rapid and efficient selection of said construct with a correct...

20060088842 - Rt-pcr-based cloning of human smn, the sma determining gene, and the construction of its expression plasmids: Spinal muscular atrophy (SMA) is a lethal autosomal recessive disease. The gene most highly associated with SMA is the survival motor neuron (SMN) gene. The present invention is a new procedure for the cloning of human SMN, the SMA determining gene, based on the reverse transcription (RT) and the polymerase...

20060088835 - Schizophrenia associated genes: The present invention relates to the identification of genes which have been disrupted in patients diagnosed as suffering from schizophrenia and/or bi-polar affective disorder, as well as proteins encoded by the gene and antibodies thereto and to uses of such products as medicaments for treating schizophrenia and/or affective psychosis. The...

20060088854 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060088853 - System and method for determining sizes of polynucleotides: The present invention relates to a method of determining whether a length of a first polynucleotide is equal to (a) a length of a second polynucleotide or (b) a length of a third polynucleotide. A sample including the first polynucleotide is provided. A first portion of the sample is combined...

20060088877 - Systematic evolution of ligands by exponential enrichment: chemi-selex: This application provides methods for identifying nucleic acid ligands capable of covalently interacting with targets of interest. The nucleic acids can be associated with various functional units. The method also allows for the identification of nucleic acids that have facilitating activities as measured by their ability to facilitate formation of...

20060088832 - Tap-70, a novel marker for epithelial tumors: Described are a novel marker protein associated with apithelial tumors, TAP-70, belonging to the family of aspartyl proteinases and nucleic acid molecules encoding TAP-70 polypeptides. Moreover, diagnostic and therapeutic uses based on the finding that TAP-70 is overexpressed throughout skin carcinogenesis are described....

20060088870 - Topographic genotyping for determining the diagnosis, malignant potential, and biologic behavior of pancreatic cysts and related conditions: The application relates to a method of a predicting the presence of invasive pancreatic cancer or high grade dysplasia, pre-cancerous pancreatic states and non-neoplastic conditions comprising detailed molecular analysis incorporating DNA quality and quantity, K-ras mutational analysis and a broad spectrum of tumor suppressor gene linked microsatellite LOH. Methods of...

20060088869 - Viral purification methods: The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filtration and column chromatography. Viruses and...

20060088824 - Wnv core protein/capsid interacting protein and uses of the same: Substantially pure WIP-1 and its use in assays to identify PAP-1/WIP-1 interaction inhibitors or WIP-1/WNV Cp interaction inhibitors are disclosed. Compositions comprising antisense sequences to prevent expression of WIP-1 and methods of treating cancer using the same are disclosed....

20060088885 - Immunoassays for topiramate: Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antigenic moieties that can be used in immunodiagnostic assays for topiramate. Also, the...

20060088887 - Method for screening substance which can bind to receptor: A method for screening a substance which can optimally bind to a receptor, by monomolecular fluorescent analysis, comprising a step of searching a substance which can bind to a receptor, and a step of performing optimization of a structure of the substance which can bind to the receptor obtained by...

20060088884 - Method of utilizing neurotrophins to manipulate reproductive capacity: Methods and kits are provided for manipulating and predicting the reproductive capacity of a female subject. The presence of endogenous neurotrophins and addition of exogenous neurotrophins, particularly BDNF, NT-4/5, and NGF, increase the reproductive capacity of a female patient by binding to receptors on the oocytes and stimulating maturation of...

20060088882 - Methods for the treatment or prevention of obesity: The invention provides methods for the treatment or prevention of obesity. The invention also provides screening methods for determining whether a compound is useful for the treatment or prevention of obesity....

20060088888 - Methods of identifying inhibitors of gadd45 polypeptide activity, and inhibitors of such activity: The present invention is directed to novel methods for assaying for modulators of GADD45 polypeptide activity. The invention also provides means to sensitize a proliferating cell to a DNA base-damaging agent by administration of novel inhibitors of GADD45 polypeptide activity. The invention further provides polypeptides which interfere with the ability...

20060088889 - Peptides for use in culture media: The present invention provides peptides libraries which are useful for rapid identification of biologically active compounds. The invention further provides peptides which include cell-growth affecting peptides and peptides which enhance or inhibit production of cellular proteins. Many of the peptides of the invention may be produced in large quantity by...

20060088883 - Recombinant catalytic polypeptides and their uses: The present invention provides a recombinant catalytic polypeptide for cleaving a target protein, the nucleic acid encoding the recombinant catalytic polypeptide, a cell hosting the nucleic acid encoding the recombinant catalytic polypeptide, and a non-human transgenic mammal that is capable of producing a heterologous antibody with proteolytic activity. The invention...

20060088886 - Topiramate analogs: Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antigenic moieties that can be used in immunodiagnostic assays for topiramate. Also, the...

20060088890 - Identification and isolation of somatic stem cells and uses thereof: The present invention relates to the identification of a specific population of cell types, in particular somatic stem cells including haematopoietic stem cells, mesenchymal stem cells and keratinocyte stem cells. The invention also provides for methods of isolation and uses of the stem cells. Derived from the methods of the...

20060088891 - Method of evaluating myelosuppressive state: The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By establishing threshold levels of certain cytokines as a surrogate for myelosuppression, treatment protocols can be optimized to reduce myelotoxicity, while maximizing effective...

20060088892 - Detection of trichomonas: The present invention is directed to diagnostic devices and methods for detecting Trichomonas infections....

20060088894 - Prostate cancer biomarkers: Protein biomarkers that may advantageously be utilized in diagnosing prostate cancer, benign prostate hyperplasia or to make a negative diagnosis are described. Accordingly, in one aspect of the invention, methods for aiding in, or otherwise making, a diagnosis of prostate cancer or benign prostate hyperplasia are provided. In one form...

20060088893 - Prostate cancer therapeutics and diagnostics based on conformers of prostatic cid phosphatase: The signals that determine important characteristics of prostate cancer, such as loss of dependence on androgens are described. A key protein, prostatic acid phosphatase, is shown to fold in different ways in response to cellular signals, and the conformer “mix” of this protein in prostatic cells may represent a fundamental...

20060088895 - Systems, methods and reagents for the detection of biological and chemical agents using dynamic surface generation and imaging: Techniques for the sensitive detection of analytes which combine the benefits of solution/suspension phase assay formats and the simplicity of solid phase/lateral flow assays are described. The assays can be performed in the solution/suspension phase using magnetic microspheres as a solid support. Subsequently a magnetic separation can be performed to...

20060088896 - Diagnostic device for rapid determination of buprenorphine: This invention relates to a method of detecting buprenorphine in biological fluids (especially urine), and to a device and kit which use chromatographically mobile reagents labelled with gold clusters. The method involves contacting urine sequentially with anti-buprenorphine antibodies labelled with gold clusters and with buprenorphine immobilised on a porous support,...

20060088897 - Modulators: Disclosed is an isoform-specific antagonist of PAK kinase, which is preferably a molecule capable of modulating an interaction between Nck and a PAK isoform. In particular, αPAK, βPAK and γPAK specific inhibitors are disclosed. Also included are methods of treating diseases, preferably characterised by a defect in nerve regeneration, comprising...

20060088898 - Methods for the production of cells and mammals with desired genetic modifications: The present invention features novel methods for generating cell lines and mammals with site-specific genetic modifications of interest. The methods involve homologous recombination between an artificial chromosome having a modification of interest and an endogenous chromosome of a cell. The resulting modified cells can be used in standard methods to...

20060088899 - Combination chemotherapy with chlorotoxin: This invention includes compositions and methods for combination chemotherapy, particularly involving at least one chemotherapeutic agent used in combination with chlorotoxin or a derivative thereof....

20060088900 - Method for determining inhibition activity of a compound on one of the enzymes of the folate synthesis pathway: The invention is directed to a method for determining the inhibition activity of a compound to be tested on at least the DHPS activity of the folate synthesis pathway, which is coupled with the detection of the release of formed inorganic phosphate. An enzymatic assay, implementing this method of determination...

20060088901 - Methods and kits for determining ubiquitin protein ligase (e3) activity: The present invention provides a method and an assay kit for detecting ubiquitin ligase (E3) activity in a sample. The method includes the steps of (1) preparing a sample mixture comprising ubiquitin, a ubiquitin activating enzyme (E1), a ubiquitin conjugating enzyme (E2), a reaction buffer, and the sample; (2) incubating...

20060088902 - Methods and materials for the identification of antifungal substrates in filamentous fungi: The present invention relates to a method for the identification of antifungal substrates, in particular substrates which are capable of combating filamentous fungi by disturbing cell wall biogenesis. A nucleotide sequence encoding α-1,3-glucan synthase including its promoter sequences is provided, obtainable from Aspergillus niger, which can be used to develop...

20060088903 - Method for the production of zymosterol and/or the biosynthetic intermediate and/or subsequent products thereof in transgenic organisms: The present invention relates to a method for preparing zymosterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts, which, compared to the wild type, have an increased lanosterol-C14-demethylase activity and increased HMG-CoA-reductase activity, to the nucleic acid constructs required for preparing the genetically modified...

20060088904 - Methods for the synthesis of astaxanthin: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished...

20060088905 - Methods for the synthesis of zeazanthin: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished...

20060088906 - Erythropoietin: remodeling and glycoconjugation of erythropoietin: The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide....

20060088912 - Compositions and methods of purifying myelin-associated glycoprotein (mag): The present invention provides compositions and methods useful for purifying recombinant myelin-associated glycoprotein (MAG) and fragments thereof. In particular, the invention provides a one-step purification method for MAG and MAG fragments. Novel forms of human recombinant MAG protein are also disclosed in addition to methods of reliably producing and storing...

20060088916 - Il-17 homologous polypeptides and therapeutic uses thereof: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060088913 - Mutation associated with epilepsy: An isolated mammalian DNA molecule encoding a mutant γ-aminobutyric acid type A (GABAA) receptor subunit, wherein a mutation event selected from the group consisting of point mutations, deletions, insertions and rearrangements has occurred and said mutation event disrupts the functioning of an assembled GABAA receptor, or an otherwise functional fragment...

20060088908 - Mutiens of human neutrophil gelatinase-associated lipocalin and related proteins: Disclosed is a method for generating a mutein of a protein selected from the group consisting of human neutrophil gelatinase-associated lipocalin (hN-GAL), rat α2-microglobulin-related protein (A2m) and mouse 24p3/uterocalin (24p3), said mutein having detectable affinity to a given target. The method comprises the step of subjecting the protein to mutagenesis...

20060088907 - Novel 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated 13237, 18480, 2245, 16228, 7677, 26320, 46619, 33166, 16836, 46867, 21617, 55562, 39228, 62088, 46745, 23155, 21657, 42755, 32229, 22325, 46863 and 32252 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 13237, 18480, 2245, 16228,...

20060088915 - Novel physiologically active peptide and use thereof: The present invention intends to provide a novel peptide and use thereof. More particularly, the present invention provides a novel peptide and a DNA encoding the same, a drug comprising the peptide or DNA, a screening method/screening kit for a compound or its salt that promotes or inhibits the activity...

20060088910 - Rt-pcr-based cloning of the human beta-amyloid precursor protein gene and the construction of its expression plasmids: Beta-amyloid peptide (βA) is a major fibrillar component of neuritic plaques in Alzheimer's disease brains and is related to the pathogenesis of the disease. βA generation depends on proteolytic cleavage of the amyloid precursor protein (APP). The present invention is a new procedure for the cloning of human βA precursor...

20060088914 - Ucp5: The present invention is directed to novel polypeptides having homology to certain human uncoupling proteins (“UCPs”) and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous...

20060088909 - Virus-like particles, methods of preparation, and immunogenic compositions: Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of liciting an immune response using immunogenic compositions that include virus-like particles are described herein. A virus-like particle (VLP) can include a viral core protein that can self assemble into the VLP core...

20060088911 - Yeast transformation system: Disclosed are methods for obtaining expression of polypeptides in organisms employing alternative codon systems, and polynucleotides for use therein....

20060088917 - Il-17 homologous polypeptides and therapeutic uses thereof: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060088918 - Novel polyphosphate:amp phosphotransferase: (wherein NMP represents nucleoside monophosphate, NDP represents nucleoside diphosphate, dNMP represents deoxynucleoside monophosphate, dNDP represents deoxynucleoside diphosphate, n represents degree of polymerization of the polyphosphate which is an integer of up to 100); (B) substrate specificity: specific to AMP, GMP, IMP, dAMP, and dGMP, also acting with CMP, UMP, dCMP,...

20060088919 - Method for producing l-amino acids using bacteria of the enterobacteriaceae family: There is disclosed a method for producing L-amino acid, for example L-threonine, L-lysine, L-histidine, L-phenylalanine, L-arginine or L-glutamic acid, using a bacterium of the Enterobacteriaceae family, wherein the bacterium has been modified to enhance an activity of D-xylose permease....

20060088920 - Microbial production of coq10: The present Invention relates to enzymes involved in the Synthesis of Coenzyme Q-10, i.e., decaprenyl diphosphate (DPP) synthase and 4-hydroxybenzoate polyprenyltransferase, to isolated DNA encoding said enzymes and to methods for the microbial production of Coenzyme Q-10....

20060088921 - Production of biodegradable thermoplastic materials from organic wastes: A system and method for converting organic wastes to biodegradable thermoplastic materials including polyhydroxyalkanoates is disclosed, which method includes treating the organic wastes with an acidogenic microbial population to form fermentative organic acids, and polymerization of the organic acids by PHA-producing microbial species to form PHAs. The system includes a...

20060088922 - Lignin blockers and uses thereof: Disclosed is a method for converting cellulose in a lignocellulosic biomass. The method provides for a lignin-blocking polypeptide and/or protein treatment of high lignin solids. The treatment enhances cellulase availability in cellulose conversion and allows for the determination of optimized pretreatment conditions. Additionally, ethanol yields from a Simultaneous Saccharification and...

20060088923 - Enzyme granulate production method and resulting enzyme granulates: A method for producing enzyme granulates, the resulting enzyme granulates, and their use in formulations, e.g., for animal feed, food, washing means, rinsing means, and/or for pharmaceutical purposes and the like. The enzyme granulates show, in particular, a high relative percentage of active enzymes, certain grain sizes, good storage stability,...

20060088924 - Erk2 crystals: The present invention relates to crystals of the ERK2 polypeptide and complexes thereof which are useful, inter alia, for structure assisted drug design....

20060088925 - Process for the intracellular over-production of streptokinase using genetically engineered strain of e.coli: An improved process for the production of streptokinase using a genetically engineered strain of Escherichia coli which overproduces streptokinase intracellularly and more particularly, the overall process disclosed herein, concerns with an improvement in the fermentative production of streptokinase using an optimized growth medium mainly comprised of simple salts and trace-elements;...

20060088926 - Method of removing hazardous substance, and hazardous substance removing material using the same such as air cleaning filter, mask and wipping sheet, and method of storing the same: A hazardous substance (20) is removed by using a hazardous substance removing material (10) in which a support (11) supports an antibody (12). Humidity of the ambient atmosphere of the antibody (12) is controlled so that the antibody (12) becomes active....

20060088927 - Method and apparatus for insulating body organs during transplantation: A method and apparatus for thermally affecting graft organs during harvesting and transplantation operations. An insulation jacket may be configured to conform to the shape of the graft organ. The insulation jacket may include a body portion constructed from a flexible surgical grade plastic, insulation foam, or thermo mass. The...

20060088928 - Method and apparatus for automatic staining of tissue samples: The present invention concerns an apparatus (1) for staining tissue samples, said apparatus (1) including a reagent section (2) or reagent containers (3); at least one staining section or tissue samples, a robotic head (22) or robotic element (20) that may move reagent to a predetermined tissue sample, said robotic...

20060088929 - Micro-reactor for gene inspection: After lysing a bacterial cell in the specimen by bacteriolysis reagent stored in bacteriolysis reagent storage section 3, and after adsorbing bacterial genes on carriers filled in carrier filling section 4, there is conducted preliminary processing for washing and detecting bacterial genes. Further, there are provided a control means that...

20060088930 - Reduced aperture biological specimen collection and transfer device: A filtration based biological specimen collection and transfer device is provided. The filtration and transfer device comprises a tubular body with two axial ends, an annular flange disposed at one of the axial ends, and a biological specimen filter affixed to the outer surface of the annular flange. Preferably, the...

20060088931 - Thermal cycling system and vessel therefor: Flexible vessels for thermal cycling a sample are provided, the flexible vessels comprising a flexible body having first and second portions coupled together and in fluid communication with each other, wherein the flexible body is configured for insertion into a thermal cycler such that the first portion is received into...

20060088932 - Gsk3 polypeptides: The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of...

20060088933 - Reagents for detecting efavirenz: The invention provides derivatives of efavirenz and methods of making derivatives of efavirenz. The derivatives include immunogenic compounds for producing antibodies to efavirenz and labeled efavirenz tracers. These compounds are useful in immunoassay methods for determining efavirenz....

20060088934 - Methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of the transcription factor atf5: The present invention provides methods for regulating the growth and/or survival of tumor cells and stem cells by modulating the expression or function of ATF5. The present invention also provides methods for promoting or suppressing differentiation of stem/progenitor cells, for producing differentiated cells and for isolating/purifying differentiated cells, including neural...

20060088935 - Method of ex vitro sowing, germination, growth and conversion of plant somatic embryos or germinants, and nutrient medium used therefor: A method of sowing a somatic plant embryo or germinant of a conifer species to facilitate subsequent development of the embryo or germinant into an autotrophic seedling. The method involves the following steps carried out ex vitro in non-sterile conditions: providing a nutrient medium comprising particles of a solid component...

20060088937 - Flavivirus expression and delivery system: The present invention provides a gene expression system comprising: a) a self-replicating expression vector of flavivirus origin which includes the flavivirus 5′ untranslated region (UTR), at least a portion of the 5′ coding region for flavivirus core protein, the nucleotide sequence coding for the flavivirus non-structural proteins, and the complete...

20060088936 - Raav expression systems for genetic modification of specific capsid proteins: Disclosed are improved recombinant adeno-associated viral (rAAV) vectors having mutations in one or more capsid proteins. Exemplary vectors are provided that have altered affinity for heparin or heparin sulfate, as well as vectors, expression systems, and rAAV virions that lack functional VP2 protein expression, but are nevertheless, fully virulent. Also...

20060088938 - Methods and compositions for use in spliceosome mediated rna trans-splicing in plants: The molecules and methods of the present invention provide a means for in vivo production of a trans-spliced molecule in a selected subset of cells. The pre-trans-splicing molecules of the invention are substrates for a trans-splicing reaction between the pre-trans-splicing molecules and a pre-mRNA which is uniquely expressed in the...

20060084051 - Grid etcher: An apparatus and process for monitoring migratory cell proliferation with restricted migration on a substrate includes providing a substrate, coating the substrate with extracellular matrix, plating cells suspended in cell culture media on extracellular matrix, and placing intersecting channels across the extracellular matrix components by removing the extracellular matrix components...

20060084052 - Detection of viable agents: A quantitative PCR method has been developed for the simultaneous detection and quantitation of an agent in samples of biologically derived materials. Unlike conventional quantitative PCR detection methods, this assay allows for the detection of viable agents....

20060084082 - 186 human secreted proteins: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing...

20060084105 - Arrays for detection of products of mrna splicing: The invention features an array comprising at least one set of nucleic acid probes for detection of gene products that are produced by mRNA splicing of a selected gene, wherein each probe set is specific for a selected gene, and wherein the probe set minimally comprises a splice junction probe...

20060084096 - Biomarkers and expression profiles for toxicology: The present invention is based on the determination of the global changes in gene expression in tissues or cells exposed to known toxins, in particular hepatotoxins, as compared to unexposed tissues or cells as well as the identification of individual genes that are differentially expressed upon toxin exposure. The invention...

20060084055 - Compositions and methods for the detection diagnosis and therapy of hematological malignancies: Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an...

20060084087 - Compositions and methods for treating episodic movement disorders and related conditions: The present invention provides compositions and methods for research, diagnostic, drug screening, and therapeutic applications related to paroxysmal dystonic choreoathetosis and related conditions. In particular, the present invention provides mutations in the myofibrillogenesis regulator 1 (MR-1) gene associated with such conditions....

20060084095 - Compositions, methods, and systems for determining bovine parentage and identity: Provided herein are methods to discover and use single nucleotide polymorphisms (SNP) for identifying parentage or identity of a bovine subject. The present invention further provides specific nucleic acid sequences, SNPs, and SNP patterns that can be used for identifying parentage of various breeds of cattle including Angus, Holstein, Limousin,...

20060084094 - Conjugates for use in hepatocyte free uptake assays: The present invention provides methods of identifying oligomeric compounds, such as siRNA and double-stranded RNA compounds, having bioactivity in vivo, and kits....

20060084053 - De novo dna cytosine methyltransferase genes, polypeptides and uses thereof: De novo DNA cytosine methyltransferase polynucleotides and polypeptides and methods for producing said polypeptides are disclosed. Also disclosed are methods for utilizing de novo DNA cytosine methyltransferase polynucleotides and polypeptides in diagnostic assays, for an in vitro DNA methylation application and therapeutic applications such as the treatment of neoplastic disorders....

20060084108 - Dna binding protein: Methods of screening for compounds which are, for example, capable of modulating amino acid-DNA interaction, modulating DNA replication, modulating cell proliferation, and for identifying compounds which inhibit cellular proliferation caused by cancer, are provided....

20060084071 - Drug targets for the treatment of neurodegenerative disorders: Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are...

20060084072 - Drug targets for the treatment of neurodegenerative disorders: Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for identifying a mutation in, or changes in expression of, a gene associated with neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease, are...

20060084064 - Endocan compositions and methods for the treatment of neoplasms: The present invention features improved diagnostic and therapeutic methods for neoplasia treatment relating to endocan nucleic acid molecules and polypeptides. In addition, the invention features methods for monitoring the responsive of a tumor in a patient to therapy; methods for suppressing the growth of a neoplasm by inhibiting endocan expression...

20060084060 - Gel having biosubstance fixed thereto and microarray utilizing the gel: The present invention provides a biological substance-immobilized gel which comprises a gel containing 2%-7% by mass of N,N-dimethylacrylamide and a biological substance immobilized on and/or in the gel....

20060084092 - Homogeneous assay system: A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification assay....

20060084100 - Information nucleic acid and information nucleic acid composition using the same: An information nucleic acid includes a base sequence portion having an arbitrary and known base sequence. The information nucleic acid is mixed with an additive such as a fat solubilizing agent, a heat stabilizer, a light stabilizer, a nucleic acid hydrolase inhibitor and/or a dispersing agent so as to form...

20060084069 - Integrated circuit optical detector for biological detection: This invention provides an integrated circuit (IC) optical detector. The IC optical detector comprises a substrate and an IC. The substrate comprises a plurality of test sites defined thereon. The test sites comprise a surface suitably treated for coating of at least one test sample. The at least one test...

20060084067 - Method and system for analysis of array-based, comparative-hybridization data: Embodiments of the present invention include methods and systems for analysis of comparative genomic hybridization (“CGH”) data, including CGH data obtained from microarray experiments. Various embodiments of the present invention include parametric and non-parametric normalization methods for CGH data, methods for identifying sets of one or more contiguous chromosomal DNA...

20060084111 - Method for gene identification signature (gis) analysis: An isolated oligonucleotide comprising at least one ditag, wherein the ditag comprises two joined first and second sequence tags, wherein the first tag comprises the 5′-terminus sequence and the second tag comprises the 3′-terminus sequence of a nucleic acid molecule or a fragment thereof. The ditag analysis is useful for...

20060084076 - Method for the amplification of genetic information: The invention relates to a method for the amplification of genetic information, wherein it is possible to analyze the frequency of unlimited partial amounts of genetic material from very small sample amounts. The inventive methods enable parallel amplification of specific target sequences of the respective partial amounts and simultaneous qualitative...

20060084078 - Method of identifying active chromatin domains: The invention provides a method of mapping DNA-protein interactions within a genome by fixing living cells to cross-link DNA and proteins, lysing the cells, and isolating chromatin by immunoprecipitation. DNA is purified and a SAGE protocol is performed on the purified DNA to produce GMAT-tag sequences, which are compared to...

20060084083 - Method to generate or determine nucleic acid tags corresponding to the terminal ends of dna molecules using sequences analysis of gene expression (terminal sage): A method of providing an indication of an instance of expression of a gene is described herein, the method which may comprise the steps of: (a) providing a complementary deoxyribonucleic acid (cDNA) having a terminus comprising a terminal transcribed sequence of a gene; (b) linking the cDNA to an linker...

20060084085 - Methods and compositions for modulating bax-mediated apoptosis: Provided herein are methods and compositions for modulating apoptosis of cells and the lifespan of cells. These may be used for treating or preventing aging-related disorders and cancer....

20060084091 - Methods and compositions for polypeptide engineering: Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed....

20060084070 - Methods and compositions for predicting drug responses: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on genotype of DNA polymorphisms and haplotypes derived from them in the VKORC1 gene....

20060084081 - Methods and compositions for predicting drug responses: The present invention relates to methods and compositions for predicting drug responses. In particular, the present invention provides methods and compositions for determining individualized Warfarin dosages based on the level of expression of the VKORC1 gene....

20060084077 - Methods and devices for identifying terrorists/criminal suspects by detecting contact of human skin with rubber protective gear: The present invention relates to devices and methods for detecting a contaminant on a surface, particularly detecting dithiocarbamates on human skin. The devices and methods are further used to identify a suspect or to conduct forensic analysis of a suspect to determine if they have come into contact with protective...

20060084080 - Methods and kits for the selection of animals having certain milk production capabilities, based on the analysis of a polymorphism in the somatotropin receptor gene: The present invention relates to a genetic marker used to distinguish amongst animals a trait for milk producing capabilities and milk composition. The marker is a mutation in the gene encoding somatotropine (also called growth hormone)-receptor (GH-R) at amino acid position 279 (a phenylalanine to tyrosine substitution in the transmembrane...

20060084061 - Methods for blocking adipocyte differentiation and triglyceride accumulation with interleukin 12 p35 inhibitors: Methods for blocking adipocyte differentiation and triglyceride accumulation with inhibitors of Interleukin 12 p35 and provided. Interleukin 12 p35 inhibitors of the present invention include small molecules, antibodies, peptides (including dominant negative peptides) and antisense compounds, including ribozymes, inhibitory RNA molecules including siRNA molecules and antisense oligonucleotides....

20060084102 - Methods for determining precise herg interactions by mutagenesis: The present invention discloses methods of determining highly precise interactions between the HERG ion channel and various compounds. The methods of the present invention utilize modified HERG ion channels combined with heterologous in vivo expression in Xenopus oocytes and mammalian cells....

20060084056 - Methods for selecting treatment regimens and predicting outcomes in cancer patients: The present invention relates to methods for determining a treatment regimen beyond surgical removal of tumor tissue for node negative or node positive breast cancer patient. The method comprises measuring the levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in a subject, preferably a tumor; and, based...

20060084104 - Methods for the detection of kidney cancer: Methods for the detection of kidney cancer are disclosed....

20060084057 - Methods of diagnosing liver fibrosis: The present invention provides a method of diagnosing the presence or severity of liver fibrosis in an individual by detecting α2-macroglobulin (α2-MG) in sample from the individual; detecting hyaluronic acid (HA) in a sample from the individual; detecting tissue inhibitor of a metalloproteinases-1 (TIMP-1) in a sample from the individual;...

20060084107 - Methods of treating skin conditions using inhibitors of the cd2/lfa-3 interaction: Methods of using inhibitors of the CD2/LFA-3 interaction-in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in mammals, including humans. Such conditions include psoriasis, UV damage, e.g., photoaging, atopic dermatitis, cutaneous T cell lymphoma such as mycosis fungoides, allergic and...

20060084110 - Methods to identify plant metabolites: This invention provides materials and methods to manipulate the plant genome at the level of single plant cells in culture resulting in the ability to assign metabolic functionality to plant genes involved in the production of biologically active molecules and to create a means of product discovery based on the...

20060084106 - Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions: An improved microfabricated apparatus for conducting a multiplicity of individual and simultaneous binding reactions is described. The apparatus comprises a substrate on which are located discrete and isolated sites for binding reactions. The apparatus is characterized by discrete and isolated regions that extend through said substrate and terminate on a...

20060084098 - Mixed-library parallel gene mapping quantitative micro-array technique for genome-wide identification of trait conferring genes: The present disclosure concerns methods and compositions relating to mixed-library parallel gene trait mapping. In particular embodiments, the methods concern quantitative microarray hybridization techniques for genome-wide identification of trait conferring genes. In other embodiments, the compositions concern genetic elements that confer or are associated with a trait. In an exemplary...

20060084079 - Modified oligonucleotides and applications thereof: Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof....

20060084090 - Modulation of interaction between nod1 and gram-negative bacteria by nod1 response to peptidoglycan delivered by the helicobacter pylori cag pathogenicity island (cagpai): A method for identifying a compound that modulates the interaction between Nod1 and a Gram-negative bacteria comprising contacting a Nod1 expressing cell with a cagPAI-positive H. pylori in the presence of a compound, contacting a Nod1 expressing cell with a cagPAI-positive H. pylori in the absence of said compound, and...

20060084097 - Modulation of nitric oxide signaling through signaling through specific regulation by arginylation and the n-end rule pathway: Screening assays that allow for the identification of agents that modulate the activity of the arginylation branch of the N-end rule pathway are provided. Also provided are method of using an agent that modulate the activity of the arginylation branch of the N-end rule pathway to increase or decrease protein...

20060084054 - Novel proteins and nucleic acids encoding same: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule...

20060084073 - Nucleic acids encoding human tbc-1 protein and polymorphic markers thereof: The invention concerns genomic and cDNA sequences of the human TBC-1 gene. The invention also concerns polypeptides encoded by the TBC-1 gene. The invention also deals with antibodies directed specifically against such polypeptides that are useful as diagnostic reagents. The invention further encompasses biallelic markers of the TBC-1 gene useful...

20060084093 - Packaging cells comprising codon-optimized gagpol sequences and lacking lentiviral accessory proteins: Novel packaging cell lines useful for generating viral accessory protein independent HIV-derived retroviral vector particles, methods of constructing such packaging cell lines and methods of using the viral accessory protein independent HIV-derived retroviral vector particles are disclosed....

20060084068 - Process for detecting a nucleic acid target: Described is a process for detecting the presence or absence of one or more target nucleotides. A primer is added to a solution containing DNA. The solution is put under conditions favorable to PCR amplification using sequence specific primers. Product is then measured to determine the presence or absence of...

20060084099 - Product identification method: A product identification method of one embodiment of the invention includes the steps of providing a product with an information nucleic acid having a segment of known base sequence randomly selected for the product, extracting the information nucleic acid from the product, amplifying the information nucleic acid by a polymerase...

20060084075 - Program for analysis of the time-series data obtained by dna array method, a method for analysis of the time-series data obtained by dna array method, and a device for analysis of the time-series data obtained by dna array method: According to this invention, a program for analysis of the time-series data obtained by DNA array method is provided, the program instructing a computer to execute a function to arrange numerical data representing the expression of genes obtained by DNA array method to a database in order of time-series, and...

20060084086 - Proteins, polynucleotides encoding them and methods of using the same: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research...

20060084103 - Pseudo-tissue for quality control and quality control method using same: A pseudo-tissue for quality control is described, which includes a nucleic acid component selected from the group consisting of a nucleic acid and a cell including a nucleic acid, and a gel for holding nucleic acid component....

20060084062 - Purification, cloning and biochemical characterization of xendou, endoribonucleasic activity involved in small nuclear rna splicing-independent biosynthesis in xenopus laevis: Cloning and characterization of the gene for Mn++ dependent RNA-sc endoribonucleasic activity able to generate 2′-3′ cyclic phosphate and 5′OH ends....

20060084063 - Rabs as modifiers of the p53 pathway and methods of use: Human RAB genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of RAB are provided....

20060084065 - Radioactive multiplexing analytical methods for biomarkers discovery: A novel analytical method involves labeling samples with different radioactive labeling agents, mixing and subjecting the mixture to any separation technique, and then differentially detecting and quantifying subcomponents from each sample for comparison. The novel technique exploits the differences in radiation energy or half-life between isotopes to make differential detection...

20060084109 - Regulated aptamer therapeutics: Materials and methods of use thereof are presented for the treatment of diabetes and other diseases. Therapeutic compositions including regulated aptamer therapeutic compositions with specificity to components of diabetes disease are presented with methods of administering these therapeutic compositions....

20060084084 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060084059 - Serum biomarkers in hepatocellular carcinoma: Certain biomarkers and biomarker combinations are useful in a qualifying hepatocellular carcinoma status in a patient. A diagnostic methodology employing these biomarkers and combinations can distinguish between hepatocellular carcinoma and chronic liver disease, for example....

20060084058 - Substrates for hybridization and method of using the same: A hybridization substrate having on a substrate surface thereof a branching nucleic acid strand comprising a principal strand of nucleic acid a portion of which is attached to the surface of the substrate and a portion of which is single-stranded, and a strand of single-stranded nucleic acid for probe that...

20060084066 - Surrogate markers of neuropathic pain: The disclosure provides methods and compositions for the evaluation of neuropathic pain and neurotrophic or other activity of a drug or drug candidate. In the disclosed methods, expression of certain gene(s) in tissue extracts from skin biopsies serves as a proxy of a relevant endpoint....

20060084088 - Tracking biological samples and their processing history: Biological samples undergo drastic changes during the execution of an experiment to aid in the determination of gene discovery, disease diagnosis, drug discovery, toxicological research, and so on. After a biological sample is processed, pieces of information about the state of a biological sample are generated. Pedigree information is also...

20060084101 - Two-color chemiluminescent microarray system: Methods, apparatus and systems for detecting target molecules in samples are provided....

20060084089 - Use of magnetic material to direct isolation of compounds and fractionation of multipart samples: Methods for isolating a compound from a multipart, typically biological sample. The methods use at least one paramagnetic particle having an associated electronic charge to bind compounds with the opposite charge to form a particle/compound complex. Alternatively, the paramagnetic particles have a ligand or functional group with an affinity for...

20060084074 - Use of whole blood in pcr reactions: A method of obtaining DNA amplification of a nucleic acid target from a volume of whole blood comprising performing DNA amplification in a PCR assay mixture with a blood-resistant polymerase....

20060084116 - Analysis of mhc-peptide binding interactions: Methods, apparatuses, and compounds for screening or detecting binding of candidate peptides to an MHC construct is provided. A first component including at least one candidate peptides and a second component including at least one MHC construct are contacted. One of the components is immobilized on a solid support. The...

20060084112 - Apolipoprotein biopolymer marker indicative of normal human: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their...

20060084113 - Directed evolution of disulfide-bonded micro-proteins: In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen bacterial cell, bacterial spore...

20060084117 - Galphaq protein variants and their use in the analysis and discovery of agonists and antagonists of chemosensory receptors: The invention provides a series of Gαq protein variants that functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory GPCRs (ORs) in an overly promiscuous manner. According to the invention, the functional coupling can be determined, for example, by measuring changes in intracellular IP3, or calcium....

20060084114 - Method for detecting cardiac collateral formation: The present invention relates to a method of detecting collateral artery formation by measuring the level of NT-pro-BNP or BNP in an individual....

20060084115 - Selective high affinity polydentate ligands and methods of making such: This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or...

20060084118 - T-bet compositions and methods of use thereof: Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a T-bet transgene. The...

20060084119 - Method of screening transporter inhibitor: Methods for measuring transporter activity using budding baculoviruses that do not express endogenous transporters on their envelope have a low background level and can measure the target activity with a high sensitivity. Such methods can be used to measure functional changes due to transporter SNPs over a more extensive range...

20060084120 - Methods and compositions for modulating hepatocyte growth factor activation: The invention provides methods and compositions for modulating hepsin activity and the HGF/c-met signaling pathway, in particular by regulating pro-HGF activation by hepsin....

20060084121 - Ox2 receptor homologs: Nucleic acids encoding mammalian, e.g., primate, receptors, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described....

20060084124 - Localization of a2b ador on human normal and diseased tissue: the use of anti-a2b antibody to diagnose and treat human tumors: The invention provides methods of detection, prevention, amelioration, and treatment for angiogenesis, including angiogenesis associated with colon cancer and glioma. The methods comprise the use of an anti-A2B antibody....

20060084122 - Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor: The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome, a method of diagnosing delayed engraftment of the hematopoietic stem cells after transplantation...

20060084125 - Methods, devices, and systems for detection of cancer: Disclosed are methods, devices, and systems for early detection of cancer. The cancer may be a glandular cancer, such as breast cancer or prostate cancer. A gland may be made to secrete fluids such that the fluids carry malignant cells that are excreted from the gland or that may be...

20060084126 - Migration inhibitory factor in serum as a tumor marker for prostate, bladder, breast, ovarian, kidney and lung cancer: Macrophage migration inhibitory factor (MIF) has been found to be overexpressed in blood of individuals having various cancers, including prostate, PIN, lung, breast, ovary, kidney and bladder. Normal levels of MIF in serum of males and females without these cancers have been quantified via immunoassay. MIF can be used as...

20060084123 - Mn and hypoxia: The MN/CA IX protein is identified herein as a hypoxia marker. The MN/CA9 gene promoter is characterized, and the location of the HIF-1 binding site within the MN/CA9 promoter is identified. Further, the hypoxia inducibility of the MN/CA9 gene and the uses of such inducibility are disclosed. In one aspect,...

20060084127 - Rapid and sensitive detection of bacteria in blood products, urine, and other fluids: The invention provides methods of detecting bacteria in fluids, including blood, platelets and other blood products for transfusion, and urine. The methods are based on lysing the bacteria to release ATP and detecting the ATP. Eukaryotic cell contamination is a problem to be overcome, because eukaryotic cell contain large amounts...

20060084128 - Enzyme assay with nanowire sensor: Systems and methods for enzyme assay using nanowire sensor are disclosed. In some embodiments, a substrate and a group suitable for assaying a target enzyme are identified. The selected substrate is immobilized to a nanowire. The target enzyme introduced to the immobilized substrate modifies the substrate to facilitate addition or...

20060084129 - Novel ways of assessing metabolic processes: The present invention provides methods for assessing contribution of one or more pathways to the biosynthesis of a metabolite, e.g., a lipid using the levels of the product made and the metabolite precursors for each pathway....

20060084131 - Method for collecting information on the primary structure of proteins, hydrophobic microparticulate carrier used in same, and system for automatically obtaining information on the primary structure of proteins: A method for obtaining information on the primary structure of peptides comprising fragmenting the proteins, which enables automation of obtaining information on the primary structure of a peptide sample; a device for use in the method; and an automatic analysis system on the primary structure of the peptides. The method...

20060084130 - Method for diagnosing a transmissible spongiform subacute encephalopathy caused by an unconventional transmissible agent strain in a biological sample: The invention relates to a method for diagnosing a transmissible spongiform subacute encephalopathy (TSSE) caused by an unconventional transmissible agent (UTA) or prion. The method involves treating a sample suspected of containing a prion with proteinase K for a time and under conditions that completely degrade normal prion protein (Prp-sen),...

20060084134 - Direct ethanol metabolite ethyl sulfate as an useful diagnostic and therapeutic marker of alcohol consumption: In particular, the use of ethyl sulfate (monoethylsulfate, molecular weight 126 g/mol, C2H5SO4H) to elucidate ethanol intake is described in the context of screening monitoring in various settings, e.g. a) after liver transplantation b) methadone maintenance patients with hepatitis C and comorbid excessive alcohol use c) underage drinking d) rehabilitation...

20060084132 - Enzyme cycling based assays for alpha-methylacyl-coa racemase: The present invention provides a method for assaying alpha-methylacyl-CoA racemase activity. In the assay, a sample containing an alpha-methylacyl-CoA racemase or suspected of containing an alpha-methylacyl-CoA racemase is contacted with (2R)-pristanoyl-CoA. If alpha-methylacyl-CoA racemase is present in the sample, (2R)-pristanoyl-CoA is converted into (2S)-pristanoyl-CoA. The method then utilizes a cycling...

20060084133 - Enzyme cycling based assays for alpha-methylacyl-coa racemase: The present invention provides a method for assaying alpha-methylacyl-CoA racemase activity. In the assay, a sample containing an alpha-methylacyl-CoA racemase or suspected of containing an alpha-methylacyl-CoA racemase is contacted with (2R)-2-methylacyl-CoA. If alpha-methylacyl-CoA racemase is present in the sample, (2R)-2-methylacyl-CoA is converted into (2S)-2-methylacyl-CoA. The method then utilizes a cycling...

20060084135 - Compositions for manipulating the lifespan and stress response of cells and organisms: Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin;...

20060084136 - Production of fusion proteins by cell-free protein synthesis: The present invention relates to in vitro protein synthesis (IVPS) systems, particularly such systems using suppressor tRNAs and rare codon tRNAs to extend translation of an open reading frame into fusion protein elements, thereby generating fusion proteins in vitro. The invention also provides methods, compositions and kits using the IVPS...

20060084137 - Use of defibrinated blood for manufacture of hemoglobin-based oxygen carrier: Red blood cells are purified by defibrinating whole blood and then filtering the defibrinated whole blood, whereby at least a portion of a plasma component is separated from the red blood cells to form a suspension of red blood cells, thereby purifying the red blood cells. Whole blood is defibrinated...

20060084142 - Activating mutations of platelet derived growth factor receptor alpha (pdgfra) as diagnostic markers and therapeutics targets: This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules...

20060084147 - Apo-2 receptor: Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided....

20060084141 - Biosynthetic gene cluster for the maytansinoid antitumor agent ansamitocin: The present invention relates to compositions and methods involving antitumor agents derived from bacteria. In particular, the present invention provides the ansamitocin biosynthetic gene cluster for the production of novel maytansinoid analogs with potent antitumor activity and reduced human toxicity....

20060084146 - Method for cell-free protein synthesis using extract solution derived from insect cell: The present invention provides a simple cell-free protein synthesis method capable of affording synthesis of a protein in a high amount in a short time at a low cost. A method for cell-free protein synthesis using an extract derived from an insect cell, the method comprising removing a component which...

20060084140 - Polynucleotide encoding a novel human g-protein coupled receptor, hgprbmy39: The present invention provides novel polynucleotides encoding HGPRBMY39 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY39 polypeptides to the diagnosis, treatment, and/or prevention...

20060084139 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060084144 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060084145 - Srage mimetibody, compositions, methods and uses: Mammalian sRAGE mimetibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to reduce or inhibit the binding of RAGE and its ligands and to treat RAGE-related diseases are also disclosed....

20060084138 - The pro4979 polypeptide: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060084143 - Tweak receptor: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac...

20060084148 - April-a novel protein with growth effects: APRIL, a novel members of the tumor necrosis factor family (TNF), modified APRILs, and pharmaceutical compositions comprising them....

20060084149 - Gene carriers with the use of polysaccharide and process for producing the same: Disclosed are gene carriers utilizing β-1,3-glucan and methods of preparing the same. The β-1,3-glucan has at least one 1,6-glucopyranoside branch and is chemically modified through periodate oxidation and reductive amination so as to impart nucleic acid-binding functional groups (for example, cationic functional groups) to at least some of the 1,6-glucopyranoside...

20060084150 - Method for manufacturing maltose-rich products: The present invention provides a method for making highly pure maltose products from starch-containing raw materials (such as corn starch, potato starch, cassava starch, sweet potato starch, wheat starch, and rice starch etc.). The method includes a combined use of amylases and other malt hydrolyzing enzymes, a spray liquefaction method,...

20060084151 - Method for producing l-glutamic acid: The present invention provides a method for producing L-glutamic acid by fermentation, by culturing in a liquid medium a microorganism that can metabolize a carbon source at a specific pH, and wherein said medium contains a carbon source and L-glutamic acid at a saturation concentration, and wherein said microorganism is...

20060084152 - Corynebacterium glutamicum genes encoding metabolic pathway proteins: Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further...

20060084153 - Method of producing diacylglycerides: Embodiments of the present invention are directed to a method of producing diacylglycerides comprising mixing one or more fatty acid esters of glycerol and at least one enzyme selected from a lipase and an endo-lipase and transesterifying at least a portion of the one or more fatty acid esters of...

20060084154 - Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids and their use as percutaneous absorption enhancers: The present invention provides a novel approach for the preparation of fatty alcohol esters of α-hydroxy carboxylic acids. In one form of the invention, the target fatty alcohol ester of α-hydroxy carboxylic acid is produced by converting a lower alkyl ester of α-hydroxy carboxylic acid into a fatty alcohol ester...

20060084155 - Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids: The gene encoding a 4-hydroxybutyryl-Co A transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, including both bacteria and plants. The new pathways provide means for producing 4HB containing...

20060084156 - Methods for producing ethanol from carbon substrates: The present invention provides means for the production of desired end-products of in vitro and/or in vivo bioconversion of biomass-based feed stock substrates, including but not limited to such materials as starch and cellulose. In particularly preferred embodiments, the methods of the present invention do not require gelatinization and/or liquefaction...

20060084157 - Hydrogen production: The enzyme, iron hydrogenase (HydA), has industrial applications for the production of hydrogen, specifically, for catalyzing the reversible reduction of protons to molecular hydrogen. The present invention relates to the isolation of a nucleic acid sequence from the algae Scenedesmus obliquus, Chlamydomonas reinhardtii and Chlorella fusca that encodes iron hydrogenase....

20060084158 - Treatment of biological material containing living cells using a plasma generated by a gas discharge: In order to treat a biological material (1) containing living cells with a plasma (4) generated by a gas discharge at atmospheric pressure (9) an electrode (3) is arranged at a distance to the biological material (1). Further, a solid body dielectric (2) is arranged between the electrode (3) and...

20060084159 - Method for manufacturing of three dimensional composite surfaces for microarrays: The present invention is directed toward the manufacturing of three-dimensional polymeric coatings for molecule (e.g., protein) immobilization on a solid surface (e.g., surface of a glass slide, microwell plate, etc.). Such surfaces find use as microarrays. In some embodiments, the 3D coating are hydrogel-based and comprise a blend of at...

20060084160 - Enzyme multimer and process of producing same: An enzyme multimer is provided which comprises a plurality of monomer units including a first monomer unit having enzymatic activity and a second monomer unit having enzymatic activity, wherein each of the first monomer unit and the second monomer unit comprise a cysteine residue and the cysteine residues of each...

20060084161 - Method of collecting highly pure polyhydroxyalkanoate from microbial cells: The present invention has an object to provide a method for separating and purifying a PHA without causing a serious decrease of the molecular weight to obtain a highly pure PHA in a high yield, which comprises efficiently removing cell components other than PHA particles from a cultured PHA-containing microbial...

20060084162 - Catalytic domains of beta(1,4)-galactosyltransferase i having altered donor and acceptor specificities, domains that promote in vitro protein folding, and methods for their use: Disclosed are methods and compositions that can be used to synthesize oligosaccharides; mutants of galactosyltransferases having altered donor and acceptor specificity; methods for increasing the immunogenicity of an antigen; and polypeptide stem regions that can be used to promote in vitro folding of polypeptides, such as the catalytic domain from...

20060084163 - Plant-derived alkaline alpha-galactosidase: There are provided novel plant-derived enzymes for hydrolysis of sugars and particularly an alkaline alpha-galactosidase which hydrolyzes a broad spectrum of galactosyl-saccharides such as melibiose, raffinose and stachyose and guar gum, at neutral to alkaline pH conditions....

20060084164 - Process for partitioning of proteins: The present invention relates to isolation and purification of protein in aqueous two-phase systems (ATPS). Specifically, the invention provides processes for partitioning of proteins of interest in ATPS by fusing said proteins to targeting proteins which have the ability of carrying said protein into one of the phases....

20060084165 - Method and apparatus for the rapid disruption of cells or viruses using micro magnetic beads and laser: A method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser are provided. According to the method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser, cell lysis within 40 seconds is possible, the...

20060084166 - Compost tea delivery system and method: The present invention is generally directed to a method and a system for producing and delivering compost tea to a predetermined location. In one aspect, a compost tea delivery system is provided. The system includes a compost tea production unit configured to produce a compost tea and a compost tea...

20060084167 - Formation of hybrid cells by fusion of lineage committed cells with stem cells: The potential of a stem cell to differentiate into specialized cell types for restoring normal tissue/organ function has stimulated interest in stem cell research. The methods used to coax stem cells differentiate into specialized cells still remain in their infancy stages. The disclosed invention is the generation of mammalian or...

20060084168 - Medium and culture of embryonic stem cells: Previous methods for culturing human embryonic stem cells have required either fibroblast feeder cells or a medium which has been exposed to fibroblast feeder cells in order to maintain the stem cells in an undifferentiated state. It has now been found that if high levels of fibroblast growth factor, gamma...

20060084169 - Polymer substrate for cultivating cells, in particular keratinozytes: The invention relates to a polymer substrate for cultivating tissue cells. The substrate is provided in form of an oxygen-permeable flat membrane, preferably with ultra-filtration properties, and has an optimized amine content of at least 10 nmole amine function per cm2 membrane. The substrate can be used to treat burns...

20060084170 - Cytokine-free growth and maintenance of progenitor cells: The invention pertains to methods and devices for the in vitro culture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors. The hematopoietic progenitor cells are cultured in the absence of exogenously added hematopoietic growth factors without loss in cell progenitor cell numbers and/or functionality, while...

20060084171 - Thermosensitive and biocompatible amphiphilic cyclic phosphazene trimer and preparation method thereof: wherein x is an integer of 3, 4, 7, 12 or 16; R is methyl, ethyl or benzyl group; R1 is selected from the group consisting of CH2CH(CH3)2, CH2C6H5, CH(CH3)CH2CH3 and CH3; R2 is selected from the group consisting of CH2COOR, CH2CH2COOR, CH2CH(CH3)2 and CH(CH3)CH2CH3; R3 and R4 are independently...

20060084172 - Method for producing stem cells with increased developmental potential: The invention relates to a method for producing stem cells having an increased development potential from somatic stem cells, wherein a tissue sample comprising somatic stem cells or a body fluid sample comprising somatic stem cells is taken from an organism, wherein from this tissue sample or body fluid sample...

20060078872 - Cell-preservation liquid: A cell-preservation liquid containing at least a saccharide, sodium ion, and potassium ion, which is characterized in that the molar concentration of the contained sodium ion is equal to or more than that of the potassium ion is provided. The preservation liquid enables not only cryopreservation but also cold preservation,...

20060078873 - Blood analysis device and blood analysis method: A blood analysis device for centrifugally separating plasma in a channel, wherein conveyance of blood, plasma and calibration liquid is effected within the device without using a pump or the like. The calibrator solution is reliably discharged from a sensor portion so as to make high precision analysis possible. A...

20060078875 - Genetic selection of small molecule modulators of protein-protein interactions: The present invention provides a method of production and screening of small molecule modulation of inter-macromolecule interaction. The method involves providing a living cell containing a gene that directs expression of a gene product to be assayed for the ability to modulate inter-macromolecule interactions and an inter-macromolecule interaction whose interaction...

20060078877 - Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis: A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location...

20060078876 - Methods of determining deficiencies in intracellular levels of cysteine and glutathione: The present invention provides cell culture media and methods useful for determining levels of intracellular function of glutathione or cysteine and for providing biochemical analysis of antioxidant function in human lymphocytes....

20060078874 - Use of nuclear hormone receptors: The present invention presents the means to identify agonists and antagonists of the NR/ligand interaction by using NRs. The term “NR” refers to any proteins either derived from a naturally occurring NR (from any species), or which shares significant structural and functional characteristics peculiar to a naturally occurring NR. Such...

20060078940 - 21132, a human g-protein coupled receptor family member and uses therefor: The invention provides isolated nucleic acids molecules, designated 21132 nucleic acid molecules, which encode novel GPCR family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 21132 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which...

20060078883 - Apparatus for forming molecular timetable and apparatus for estimating circadian clock: An apparatus 11 for estimating internal biological time of a biological individual on the basis of quantity data of a gene product as measured in a specimen sampled from the individual. The apparatus includes circadian oscillatory gene selection means for selecting circadian oscillatory genes whose time-course change in gene product...

20060078889 - Array-based methods for producing ribonucleic acids: Methods and compositions for generating pluralities of ribonucleic acids are provided. In the subject methods, an array is employed as a template in an in vitro transcription reaction. Also provided are the arrays employed in the subject methods and kits for practicing the subject methods. The ribonucleic acid pluralities produced...

20060078939 - Biochip substrate: The object is to provide a biochip substrate which is suitable for high density and high precision immobilization of DNA probes by stamping and for fabrication of a biochip which secures a high S/N ratio and high spot homogeneity at each spot without blurring or other problems when used. A...

20060078921 - Biomarkers and expression profiles for toxicology: The present invention is based on the determination of the global changes in gene expression in tissues or cells exposed to known toxins, in particular hepatotoxins, as compared to unexposed tissues or cells as well as the identification of individual genes that are differentially expressed upon toxin exposure. The invention...

20060078886 - Business methods for modulating angiogenesis: The present invention relates business methods comprising the steps of commercializing a tRNA synthetase fragment or a multi-unit complex comprising a tRNA synthetase fragment for modulating an angiogenesis-mediated condition. In some embodiments, the business methods herein include the step of expressing a tRNA synthetase fragment recombinantly. In some embodiments, the...

20060078893 - Compartmentalised combinatorial chemistry by microfluidic control: The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary...

20060078913 - Compositions, splice variants and methods relating to cancer specific genes and proteins: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the...

20060078884 - Corynebacterium glutamicum genes encoding stress, resistance and tolerance proteins: Isolated nucleic acid molecules, designated SRT nucleic acid molecules, which encode novel SRT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing SRT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further...

20060078885 - Detection and diagnosis of smoking related cancers: Gene probes for specific regions of chromosome 3 (3p21.3) and chromosome 10 (10q22) have been found to be tools for the diagnosis and prognosis of smoking related cancers such as non-small cell lung cancer (NSCLC). For example, these probes can be used with fluorescence in situ hybridization (FISH), and used...

20060078929 - Device for the amplification and detection of nucleic acids: The present invention relates to a device for the amplification and for the detection of nucleic acids comprising a temperature controlling and/or regulating unit; a reaction chamber containing a support with a detection area, on which a compound library is immobilized, wherein the temperature in the reaction chamber can be...

20060078919 - Diagnostic test kit and methods of diagnosis and treatment of helicobacter spp. associated infections: The present diagnostic test kit and methods of diagnosis and treatment of Helicobacter spp. associated infections provides accurate diagnosis and treatment for Helicobacter spp. related infections and diseases. The method of diagnosis includes analyzing a tissue specimen from a patient diagnosed with a disease. The tissue specimen can be a...

20060078941 - Gene expression profiling in primary ovarian serous papillary tumors and normal ovarian epithelium: Gene expression profiling and hierarchial clustering analysis readily distinguish normal ovarian epithelial cells from primary ovarian serous papillary carcinomas. Laminin, tumor-associated calcium signal transducer 1 and 2 (TROP-1/Ep-CAM; TROP-2), claudin 3, claudin 4, ladinin 1, S100A2, SERPIN2 (PAI-2), CD24, lipocalin 2, osteopontin, kallikrein 6 (protease M), kallikrein 10, matriptase and...

20060078938 - Haplotyping method for multiple distal nucleotide polymorphisms: The invention relates to methods for detecting genetic polymorphisms in an organism, particularly to the detection of genetic polymorphisms that are due to multiple distal nucleotide polymorphisms within a gene. Methods are provided for determining the haplotype structure of a gene, or other contiguous DNA segment, having two or more...

20060078916 - Hm74 and hm74a in cuboidal endothelial cells as associated with inflammation: Disclosed herein are methods of diagnosing and monitoring the severity of inflammatory diseases. Also disclosed herein are methods for screening for compounds which are effective at reducing the symptoms associated with an inflammatory disorder. Such compounds can be used in the methods of treating inflammatory disorders as disclosed herein....

20060078914 - Homogeneous assay system: A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for detection. This process is easily incorporated into a PCR amplification, assay....

20060078933 - Il-receptor like molecules and uses thereof: The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of...

20060078888 - In vitro evolution in microfluidic systems: The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; and (b) sorting the genetic elements which express the gene product having the desired activity; wherein at least one step...

20060078901 - Listeria monocytogenes genome, polypeptides and uses: The genome sequence and nucleotide sequences of Listeria monocytogenes EGD-e are provided. Polypeptide sequences, including surface or cell envelope polypeptides, and polypeptides involved in metabolism, including B12 biosynthesis, are also provided. Uses of these sequences are also provided....

20060078902 - Method and compositions for rna interference: The invention provides methods and compositions related to the field of gene expression regulation. In particular, methods and compositions of the invention can be used to identify RNAi cleavage sites along a target RNA molecule. Methods and compositions of the invention may also be used to knockdown expression of nucleic...

20060078881 - Method and kit for detection of mutations in mitochondrial dna: The present invention is within the medical field. More precisely, the invention relates to a method and kit for defection of mutations/polymorphisms in human mitochondrial DNA sequences and specifically to the use of mitochondrial DNA variants (polymorphisms) with high mutation frequency to be employed in the comparison of biological samples...

20060078934 - Method for acceleration and intensification of target-receptor binding and devices therefor: The present invention relates to a device for the simultaneous conduction of a multiplicity of binding reactions on a substrate with a first surface, said surface comprising discrete and isolated locations of one such binding reaction, said binding reaction being generated upon contact between the substrate and a fluidic sample...

20060078923 - Method for isolating nucleic acids: Described herein is a method in which genomic nucleic acid of a cell can be separated from nucleic acid having a molecular weight that is lower than the molecular weight of the genomic nucleic acid (e.g., plasmid DNA) of the cell directly from a cell growth culture. Also described herein,...

20060078897 - Method of providing customized drug delivery correlating to a patient's metabolic profile: A novel method of correlating the disposition of a specific drug in an individual patient to a controlled and modulated delivery system for optimizing therapeutic response of orally ingested dosage forms is provided. Such a method broadly encompasses a first determination of an individual's metabolic rate in terms of absorption...

20060078942 - Method of treatment using interferon-tau: Methods of treating an autoimmune condition, a viral infection, or a condition of cellular proliferation by administering IFNτ are described. More specifically, a method of up-regulating the IL-10 level in patients afflicted with an autoimmune condition, a viral infection, or a condition of cellular proliferation by administering IFNτ is described....

20060078896 - Method, system, and computer program product to assess properties of a chemical array: A method, a system, and a computer-readable medium storing a program for determining array quality during in-situ manufacturing of an array includes determining an average feature coverage fraction of the array, determining a background area fraction of the array, measuring a contact angle of the background, and determining the array...

20060078894 - Methods and compositions for analyzing nucleic acids: Methods and compositions for probe amplification to detect, identify, quantitate, and/or analyze a targeted nucleic acid sequence. After hybridization between a probe and the targeted nucleic acid, the probe is modified to distinguish hybridized probe from unhybridized probe. Thereafter, the probe is amplified. Moreover, in specific embodiments, the present invention...

20060078899 - Methods and compositions for reducing label variation in array-based comparative genome hybridization assays: Methods and compositions for producing a labeled population of nucleic acids for use in an array-based comparative genome hybridization (CGH) assay are provided. In general, the methods involve cleaving a genomic source to produce a sample containing nucleic acid fragments, and end-labeling the nucleic acid fragments to provide a population...

20060078898 - Methods and compositions for reducing label variation in array-based comparative genome hybridization assays ii: Methods and compositions for performing array-based CGH assays are provided. In general, the methods involve evaluating copy number of a genomic region by evaluating binding of distinguishably labeled populations of nucleic acids to a first CGH array in which: a) the populations of nucleic acids are labeled by a labeled...

20060078912 - Methods and compositions for the detection of biological molecules using a two particle complex: The invention provides methods of detecting analytes of interest in a sample using electrogenerated chemiluminescence. The invention also provides compositions comprising at least one solid support that entraps or contains an electrogenerated chemiluminescent moiety....

20060078903 - Methods and compositions for the diagnosis and treatment of cyclin a-1 associated conditions: The present invention relates to compositions and methods for cancer therapeutics. In particular, the present invention provides compositions and methods for inhibiting cancer metastasis by inhibiting cyclin A1....

20060078926 - Methods and computer program products for analysis and optimization of marker candidates for cancer prognosis: Methods and computer program products for evaluating and optimizing one or more markers for use in establishing a prognosis for a patient suffering from a disease are provided. More particularly, the methods include steps for systematically evaluating a number of features that may be extracted from an image of a...

20060078904 - Methods for detecting chromosome aberrations: The present invention relates to methods for detecting a change in chromosomal structure. These methods employ labeled probes that bind nucleic acids. For example, these probes may be comprised of nucleic acids or nucleic acid analogs and a detectable label....

20060078882 - Methods for diagnosis and prognosis of cancer: We have discovered a protein in humans, herein referred to as collagen like gene (CLG) product (SEQ ID NOS: 12 and 13), that is expressed in human prostate cancer and breast cancer cell lines but not in normal adult, placenta, lung, liver, skeletal muscle, kidney or pancreas tissues. We have...

20060078890 - Methods for identifying parkinson's disease therapeutics: The present invention features methods of identifying candidate compounds for treating and preventing neurodegenerative disorders such as Parkinson's disease....

20060078895 - Methods for in situ generation of nucleic acid arrays: Methods of producing nucleic acid arrays using an in situ nucleic acid synthesis protocol are provided. Embodiments include a functional group generation step performed by flowing a plurality of different fluids across the surface of a substrate in a manner such that any given lower density fluid is always above...

20060078927 - Methods for in situ generation of nucleic acid molecules: Methods of producing nucleic acid molecules using an in situ nucleic acid synthesis protocol are provided. The method can comprise contacting a substrate comprising an attached blocked nucleoside monomer or polymer with a deblocking fluid to remove the blocking group, thereby generating an unblocked attached nucleoside monomer or polymer; displacing...

20060078887 - Methods for screening for anti-angiogenic agents: The present invention relates to methods for screening for anti-angiogenic agents. Such methods may include the steps of contacting a receptor of a tRNA synthetase fragment with a member of a library of candidate agents and selecting a candidate agent from the library that selectively binds to such receptor....

20060078920 - Methods to identify and quantify oligosaccharide modifications of glycoproteins: Methods are disclosed for identifying oligosaccharides found on proteins and identifying those that are modified in disease states....

20060078906 - Methods, compositions, and kits comprising linker probes for quantifying polynucleotides: The present invention is directed to methods, reagents, kits, and compositions for identifying and quantifying target polynucleotide sequences. A linker probe comprising a 3′ target specific portion, a loop, and a stem is hybridized to a target polynucleotide and extended to form a reaction product that includes a reverse primer...

20060078931 - Microchip unit, and method of conducting biochemical reaction using the microchip unit: Provided is a microchip unit, including a microchip on which a plurality of micro-channels are formed, a housing disposed below the microchip to fix the microchip; and at least two injecting and sealing elements having through-holes corresponding to inlets of the microchip. The injecting and sealing elements are vertically fixed...

20060078900 - Molecular toxicology modeling: The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database...

20060078932 - Multi-mer peptides derived from hepatitis c virus envelope proteins for diagnostic use and vaccination purposes: Multimer peptides (e.g. 30- to 45-mer peptides) derived from hepatitis C virus envelope proteins reacting with the majority of anti-HCV antibodies present in patient sera are described. The usage of the latter peptides to diagnose, and to vaccinate against, an infection with hepatitis C virus is also disclosed....

20060078908 - Multianalyte sensor: The invention relates to devices for continuously measuring the concentrations of more than one target analyte. Specifically, the devices comprise a plurality of analyte binding domains, with each domain being capable of specifically and reversibly binding to at least one of the target analytes. The devices further comprise a membrane...

20060078907 - Nanomachine compositions and methods of use: The invention provides a basic genetic operating system for an autonomous prototrophic nanomachine having a nanomachine genome encoding a minimal gene set sufficient for viability. Also provided is a basic genetic operating system for an autonomous auxotrophic nanomachine having a nanomachine genome encoding a minimal gene set sufficient for viability...

20060078918 - Natural ligand for orphan g protein coupled receptor gpr86 and methods of use: The present invention is related to a method of detecting the dysregulation of GPR86 activity....

20060078925 - Novel microarray techniques for nucleic acid expression analyses: Provided are DNA microarray techniques that allow hybridization without RNA amplification, without using cDNA, and without labeling the nucleic acid prior to hybridization. Referred to as the Double-stranded Exonuclease Protection (DEP) assay, the technique permits the sample RNA to be used directly for hybridization, without manipulation in any way. Further...

20060078922 - Novel purified polypeptides from haemophilus influenzae: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention....

20060078909 - Novel sulfurylase-luciferase fusion proteins and thermostable sulfurylase: The present invention relates to the field of DNA recombinant technology. More specifically, this invention relates to fusion proteins comprising an ATP generating polypeptide joined to a polypeptide that converts ATP into a detectable entity. Accordingly, this invention focuses on sulfurylase-luciferase fusion proteins. This invention also relates to pharmaceutical compositions...

20060078891 - Nucleic acid arrays comprising a set of hybridization parameter determination features and methods for using the same: Nucleic acid arrays that include a set of hybridization parameter probe features are provided. Also provided are methods of using the subject arrays in hybridization assays. In certain aspects, signals detected from the hybridization parameter probe features may be employed to determine a hybridization parameter of the assay. The subject...

20060078911 - Oxidative dna damage protection: Provided herein are methods of screening compounds, gene sequences, and gene products in bacteria for agents that are protective against oxidative DNA damage in a human or animal. Gene sequences identified by these screens can also be used in diagnostic assays that identify subjects at increased risk for oxidative DNA...

20060078910 - Polygonal nanostructures of polynucleic acid multi-crossover molecules and assembly of lattices based on double crossover cohesion: Robust nucleic acid arrays and lattices are assembled based on double crossover cohesion of polygonal units whose edges are composed of nucleic acid multi-crossover domains....

20060078879 - Polymorphisms in the human gene for tpmt and their use in diagnostic and therapeutic applications: The present invention relates to a polymorphic TPMT polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or...

20060078930 - Primers, methods and kits for amplifying or detecting human leukocyte antigen alleles: The present invention describes primers, methods and kits for amplifying and identifying HLA alleles. Using these primers, all HLA alleles at a single locus can be amplified using either a multiplex or non-multiplex PCR approach. Within sets of the primers, control primer pairs may be used to produce control amplicons...

20060078892 - Prion protein binding materials and methods of use: Prion protein binding materials and methods for using the binding materials to detect or remove a prion protein from a sample, such as a biological fluid or an environmental sample. The binding materials are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc),...

20060078905 - Quantitative analysis of dna: The present invention is related to a novel approach for quantitation of DNA based on the stoichiometric existence of phosphorus (P) in DNA....

20060078878 - Regulation of endogenous gene expression in cells using zinc finger proteins: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins....

20060078937 - Sequencing nucleic acid using tagged polymerase and/or tagged nucleotide: The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the polymerization reaction is measured on a molecule of nucleic acid, i.e. the activity of a nucleic acid polymerizing enzyme...

20060078936 - Solid support assay systems and methods utilizing non-standard bases: Solid support assays using non-standard bases are described. A capture oligonucleotide comprising a molecular recognition sequence is attached to a solid support and hybridized with a target oligonucleotide. In some instances, the molecular recognition sequence includes one or more non-standard bases and hybridizes to a complementary tagging sequence of the...

20060078935 - Surface assembly for immobilizing dna capture probes in genetic assays using enzymatic reactions to generate signal in optical bio-discs and methods relating thereto: The invention relates to methods and systems for use of bio-discs in quantifying an amount or concentration of one or more substances that are present in a biological sample. The system includes an optical disc having one or more samples deposited thereon, an optical element configured to emit and divert...

20060078915 - Systems and methods for detecting and analyzing polymers: A detection system and methods for improving the ability of the detection system to recognize labels that are disposed on a polymer. Embodiments of the invention include schemes for selecting emitters and labels used within the system in a manner that allows an increase in the number of distinct labels...

20060078917 - Systems, methods and software arrangements for detection of genome copy number variation: The present invention relates to systems, methods and software arrangements for the detection of variations in the copy number of a gene in a genome. These systems, methods and software arrangements are based on a simple prior model that uses a first process generating amplifications and deletions in the genome,...

20060078928 - Thermostable enzyme promoting the fidelity of thermostable dna polymerases-for improvement of nucleic acid synthesis and amplification in vitro: A purified thermostable enzyme is derived form the thermophilic archaebacterium Archaeoglobus fulgidus. The enzyme can be native or recombinant, is stable under PCR conditions and exhibits double strand specific exonuclease activity. It is a 3′-5′ exonuclease and cleaves to produce 5′-mononucleotides. Thermostable exonucleases are useful in many recombinant DNA techniques,...

20060078924 - Two-color real-time/end-point quantitation of micrornas (mirnas): The present invention is directed to methods, reagents, kits, and compositions for detecting target polynucleotide sequences, especially small target polynucleotides such as miRNAs, between two samples. A pair of linker probes can be employed in two different reactions to query a particular species of target polynucleotide. A pair of detector...

20060078880 - Zinc finger libraries: A library of multimeric DNA binding polypeptides is provided. Preferred such polypeptides are zinc finger protein DNA binding domains. Libraries of nucleotides encoding such polypeptides, expression vectors containing such nucleotides, cells containing any of the libraries and uses of the libraries are also provided....

20060078945 - Complex formed by n-linked glycoproteins (siblings) and factor h: The invention provides methods and compositions for exploiting the discovery that members of the small integrin-binding ligand, n-linked glycoproteins family termed SIBLINGS bind to complement Factor H, and moreover that SIBLINGS proteins, such as BSP, exist in relatively acidic forms. The methods provided can be used to detect SIBLINGS proteins...

20060078943 - Method for obtaining anti-idiotype antibodies: A method for identifying molecules which mimic an idiotype of an autoimmune disease-associated auto-antibody (autoantibodies). The method comprises the following steps: (a) purifying autoantibodies from sera of one or more patients afflicted with the autoimmune disease; (b) binding the autoantibodies to a solid phase to form an affinity matrix; (c)...

20060078944 - Methods and reagents relating to inflammation and apoptosis: The present invention relates to, among other embodiments, protein complexes which include tumor necrosis factor alpha (TNF-α) and/or tumor necrosis factor alpha receptor (TNFR). Preferably, the complexes comprise at least one polypeptide selected from the group consisting of: NF-κB activating kinase (NAK), RasGAP3, TRCP1, and TRCP2. The present invention further...

20060078946 - Method for manufacturing antigen-specific antibody-producing hybridomas employing a single antigen-specific b lymphocyte and method for manufacturing monoclonal antibody: A method for producing a monoclonal antibody and antigen-specific antibody-producing hybridomas using a single antigen-specific B lymphocyte is provided. The method for producing antigen-specific antibody-producing hybridomas comprises selecting a single B lymphocyte reacting specifically with a certain antigen, an “antigen-specific B lymphocyte”, culturing the antigen-specific B lymphocyte selected, and fusing...

20060078947 - Methods and compositions for treating hematological disorders using 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 14310, 17600, 25584, 27824, 284: The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 9118, 990, 17662, 81982, 630, 21472, 17692, 19290, 21620, 21689, 28899, 53659, 64549, 9465, 23544, 7366, 27417, 57259, 21844, 943, 2061, 5891, 9137, 13908, 14310, 17600, 25584,...

20060078949 - Flow cytometry based micronucleus assays and kits: The invention is a method for analyzing immature reticulocytes for the presence of micronuclei. The method includes reticulocyte enrichment, fluorescent labeling, micronuclei staining, and analysis using single-laser flow cytometry. The invention also includes kits containing reagents to use in the method....

20060078950 - Identification of porphyromonas gingivalis virulence polynucleotides for diagnosis, treatment, and monitoring of periodontal diseases: The invention provides compositions and methods for the detection of Porphyromonas gingivalis and for the treatment and prevention of diseases and infections caused by P. gingivalis....

20060078952 - Method for identifying antimicrobial molecules which interfere with apolipoprotein n-acyltransferase activity: Products, compositions and methods useful for screening compounds or test molecules for their ability to modulate apolipoprotein N-acyltransferase activity....

20060078951 - Monoclonal antibody selectively recognizing listeria monocytogenes, hybridoma producing the antibody, test kit comprising the antibody and detection method of listeria monocytogenes using the antibody: The present invention relates to a monoclonal antibody binding specifically to the p60 protein of Listeria monocytogenes, a hybridoma cell producing the monoclonal antibody, a test kit comprising the monoclonal antibody, and a method for detecting Listeria monocytogenes using the monoclonal antibody. The inventive monoclonal selectively recognizes only Listeria monocytogenes,...

20060078948 - Analytical method, analytical instrument, microarray and immunoassay of biological samples: An object of the present invention is to provide an analytical method and an analytical instrument with high capability of quantitative determination and reproducibility which can be used for detecting the minor difference between expression levels and measuring the protein concentration, for example. An analytical method for a biological sample...

20060078954 - Device and method to simultaneously detect different antibodies and antigens in clinical alimentary and environmental samples: Method and device to simultaneously detect different antibodies and antigens via immunoenzimatic tests and ELISA (Enzyme Linked ImmunoSorbent Assay) constituted by small absorbent cylinders, on which the immunocomplexes are formed, blocked at a modular distance on a probe; that carries a label to identify the sample under examination....

20060078953 - Epad, an oocyte specific protein: The present invention is directed to a human egg specific protein (ePAD), antibodies specific for the human egg specific protein and the use of the ePAD protein to identify antagonists of ePAD activity. Antagonists of ePAD activity are anticipated to have utility as female contraceptive agents....

20060078955 - Method for retrieving delta9-thc from oral fluid: The present invention discloses methods and kits for retrieving a cannabinoid from an oral fluid collection device having adsorbed the cannabinoid and to prepare an oral fluid specimen for the determination of Δ9-tetrahydrocaninabinol (Δ9-THC) concentration qualitatively or quantitatively by an enzyme immunoassay. The methods and kits are particularly useful in...

20060078956 - Methods to identify compounds that modulate rage: Provided are methods to detect of modulators of the Receptor for Advanced Glycated Endproducts (RAGE). The invention comprises a method for detection of RAGE modulators comprising: adsorbing a RAGE ligand onto a solid surface; adding a compound of interest and a protein comprising RAGE or fragment thereof, to the preadsorbed...

20060078957 - Novel aggrecanase: A novel polypeptide, a polynucleotide encoding this polypeptide, an expression vector comprising this polynucleotide, a cell transfected with the expression vector, an antibody binding to the above polypeptide, a convenient screening method for obtaining an agent for treating joint diseases, and a process for manufacturing a pharmaceutical composition for treating...

20060078958 - Method of multiple quantification of cholesterol in low-density lipoproteins: The present invention is intended to provide a method for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol as test components in blood. Specifically, a method is used for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol in a biological sample, whereby cholesterol in low density...

20060078959 - Recombinant chondroitinase abc i and uses thereof: The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans...

20060078960 - Expression quantification using mass spectrometry: In various aspects, the present teachings provide systems, methods, assays and kits for the absolute quantitation of protein expression. In various aspects, the present teachings provide methods of determining the concentration of one or more proteins of interest in one or more samples of interest. In various aspects, the present...

20060078961 - Systems and methods for rapidly changing the solution environment around sensors: The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention can be applied in any sensor technology in which the sensing element needs to be exposed rapidly, sequentially, and controllably, to a...

20060078963 - Methods for producing modified glycoproteins: Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar, if not substantially identical, to their human counterparts. The lower...

20060078962 - Polysaccharide-based polymers and methods of making the same: Gels and polymers comprising a polypeptide bound to a polysaccharide are disclosed. Specific polypeptides include, but are not limited to, polypeptides that comprise glutamine or tyrosine residues. Specific polysaccharides include, but are not limited to, chitosan. Gels and polymers of the invention can be used for the in vitro and...

20060078967 - Antibodies for il-17 receptor like polypeptides and uses thereof: The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of...

20060078965 - Chinese hamster ovary cell line transfected with 30k gene: The present invention relates to a CHO (Chinese hamster ovary) cell line transfected with 30 K gene. More particularly, the present invention is directed to a CHO cell line transfected with 30 K genes obtained from the silkworm Bombyx Mori, which has anti-apoptotic property....

20060078966 - Il-17 receptor like polypeptides and uses thereof: The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of...

20060078964 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060078968 - Sequence specific dna recombination in eukaryotic cells: The present invention relates to a method of sequence-specific recombination of DNA in eukaryotic cells, comprising the introduction of a first DNA comprising a nucleotide sequence containing at least one recombination sequence into a cell, introducing a second DNA comprising a nucleotide sequence containing at least one further recombination sequence...

20060078970 - Fusion polypeptide suitable as a cytotoxin: The present invention relates to fusion polypeptides including (a) a binding site for a cytoskeleton component and (b1) an effector protein or the catalytic domain thereof or (b2) a binding site for the effector protein, and nucleic acid sequences encoding the fusion polypeptides. Moreover, various therapeutic uses of the fusion...

20060078969 - Regulated transcription of targeted genes and other biological events: Dimerization and oligomerization of proteins are general biological control mechanisms that contribute to the activation of cell membrane receptors, transcription factors, vesicle fusion proteins, and other classes of intra- and extracellular proteins. We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins. In principle,...

20060078971 - Isoflavone-beta-d-glucan produced by agaricus blazei in the submerged liquid culture and method of producing same: The present invention relates to low and medium molecular weight isoflavone-β-D-glucan produced by submerged liquid culture of Agaricus blazei, a method of producing the isoflavone-β-D-glucan using autolysis enzyme of Agaricus blazei mycelia, and use of the isoflavone-β-D-glucan for anti-cancer and immunoenhancing effect....

20060078972 - Production of 5'-ribonucleotides: The present invention describes a composition comprising at least 55% w/w (on sodium chloride free dry matter weight) of 5′-ribonucleotides and a process for the production of this composition comprising the steps of: (i) treating microbial cells to release the cell contents comprising RNA; (ii) separating the RNA present in...

20060078973 - Process for the production of unsaturated fatty acids: The invention relates to processes for the production of unsaturated fatty acids, preferably of conjugated polyunsaturated fatty acids such as conjugated linoleic acid (CLA), by the recombinant expression of desaturases from insects of the order Lepidoptera. Expression preferably takes place in an organism selected from the group of the plant...

20060078974 - Novel purified hydroxymethylglutaryl-coa reductases and structures thereof: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention....

20060078975 - Crystal structure of enzyme and uses thereof: The invention provides crystalline forms of a polypeptide corresponding to the catalytic domain of Aurora kinase. The active site ATP binding pocket is defined by its amino acid residues and their atomic coordinates. This structure may be used to select or design chemical modulators of Aurora kinase, particularly Aurora inhibitors....

20060078976 - Crystal structures of bacterial thymidylate kinases: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 8. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention....

20060078977 - Novel purified polypeptides from enterococcus faecalis: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention....

20060078978 - Alkaline protease: The present invention provides an alkaline protease exhibiting high detergency and productivity, which is obtained by further enhancing the detergency of an alkaline protease effective against complex dirt and enhancing the specific activity....

20060078979 - Method to reduce contamination when culturing mycobacteria: Provided is a method for culturing Mycobacteria in the presence of a class A lantibiotic, thereby inhibiting or reducing bacterial contamination in the culture, without significantly disadvantageously affecting or retarding mycobacterial growth. Further provided are the Mycobacteria culture produced thereby, methods for detecting Mycobacteria in a biological sample under conditions...

20060078980 - Production of polyketides and other natural products: The present invention relates to production of polyketides and other natural products and to libraries of compounds and individual novel compounds. One important area is the isolation and potential use of novel FKBP-ligand analogues and host cells that produce these compounds. The invention is particularly concerned with methods for the...

20060078981 - Reducing branching and enhancing fragmentation in culturing filamentous microorganisms: The invention relates to the field of microorganisms and in particular to the culturing of microorganisms. The invention provides means and methods for enhancing the culturing properties of filamentous microorganisms, in particular filamentous fungi. The means and methods according to the invention comprise reducing branching and/or enhancing the fragmentation of...

20060078982 - Biomass generator: A biomass generator useful for continuously growing and withdrawing bacteria to be used in a desired beneficial application, the generator having a bacteria growth chamber; water and nutrient inlet ports; upper and lower outlet ports; a recirculating pump withdrawing and reintroducing fluid to establish a vortex in the growth chamber...

20060078983 - Polymer monolith substrate: The present teachings provide for composite substrates for the covalent attachment of biomolecules and method of making the same. The present teachings provide for composite substrates comprising a porous copolymer-monolith covalently attached to a surface of a substrate, wherein the porous copolymer-monolith has been formed by an inverse phase photo-copolymerization...

20060078986 - Analytical devices with primary and secondary flow paths: The present invention provides analytical devices comprising primary and secondary flow paths. A secondary flow path is configured to allow for a portion of a liquid sample to enter the secondary flow path from a primary flow path and subsequently be drawn back into the primary flow path, thereby providing...

20060078985 - Device and method for quantitatively measuring immobilized sample: Evaluation of an amount of immobilized sample in a surface plasmon resonance (SPR) immunoassay is provided. To immobilize the sample, a sensor unit has a sensing surface. The sensor unit includes a transparent dielectric medium, and a metal film having the sensing surface. The metal film is connected with the...

20060078984 - Sensors for biomolecular detection and cell classification: A sensor device is provided for detecting an analyte in a sample in which an analyte is bound to a detection reagent to form a bound complex. The device comprises (a) a sample (5) comprising an ionic analyte and a detection reagent in a conductive fluid, wherein the detection reagent...

20060078987 - Compost container: A collapsible compost container is provided. The container has a hollow tubular body comprised of a flexible and breathable synthetic textile. Rigid first and second open end rims at opposite ends of the tubular body are connected by a helical spring that biases the open end rims away from each...

20060078988 - Device and method for storage and transportation of forensic and/or biological material: A device for storage and transportation of forensic and/or biological material, comprising a sealable container and a material holder for holding the material, which holder can be placed in the container, wherein the container is provided with at least one ventilating hole and with sealing means that shut off the...

20060078989 - Dedifferentiated, programmable stem cells of monocytic origin, and their production and use: The invention relates to the production of adult dedifferentiated, programmable stem cells from human monocytes by cultivation of monocytes in a culture medium which contains M-CSF and IL-3. The invention further relates to pharmaceutical preparations, which contain the dedifferentiated, programmable stem cells and the use of these stem cells for...

20060078990 - Antibody composition-producing cell: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for...

20060078991 - Antibody composition-producing cell: The present invention relates to a cell for the production of an antibody molecule such as an antibody useful for various diseases having high antibody-dependent cell-mediated cytotoxic activity, a fragment of the antibody and a fusion protein having the Fc region of the antibody or the like, a method for...

20060078992 - Novel vectors for animal cells and use thereof: Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated by substitution in a gene encoding a ribosome-constituting protein derived from an animal....

20060078993 - Isolation, cultivation and uses of stem/progenitor cells: The present invention relates to a method for isolating stem/progenitor cells from the amniotic membrane of umbilical cord, wherein the method comprises separating the amniotic membrane from the other components of the umbilical cord in vitro, culturing the amniotic membrane tissue under conditions allowing cell proliferation, and isolating the stem/progenitor...

20060078994 - Mature dendritic cell compositions and methods for culturing same: This invention provides methods to prepare and use immunostimulatory cells for enhancing an immune response. The invention provides a method for preparing mature dendritic cells (DCs), comprising the sequential steps of: (a) signaling isolated immature dendritic cells (iDCs) with a first signal comprising an interferon gamma receptor (IFN-γR) agonist and/or...

20060078995 - Method of using fish plasma components for tissue engineering: A process of using a fish plasma component for tissue engineering includes obtaining a fish that is a progeny of domesticated broodstock that are reared under consistent and reproducible conditions. Blood is obtained from the fish. Plasma is separated from the blood. One or more specific components of the plasma...

20060078996 - Surface transfection and expression procedure: The present invention relates to a method of transfecting cells comprising applying cells directly onto nucleic acids which are immobilized in transfection complexes on a surface and which transfect the cells. Preferably, the nucleic acids are immobilized in an array. In another aspect of the present invention, the method further...

20060073467 - Biocompatible polymer and filter for selectively eliminating leucocytes using the same: It is intended to provide a polymer which is scarcely eluted, has a high biocompatibility and is useful in a filter for selectively eliminating leucocytes. It is also intended to provide a filter for selectively eliminating leucocytes, a filtration apparatus for selectively eliminating leucocytes and a system for selectively eliminating...

20060073472 - Anti-inflammatory and protein kinase inhibitor compositions and related methods for downregulation of detrimental cellular responses and inhibition of cell death: A novel class of pyridazine compositions and related methods of use....

20060073473 - Cytotoxic assay and new established cell line of sturgeon origin: An object of the present invention is to provide a cytotoxic assay using a new established fish cell line. The invention attained according to the object is a cytotoxic assay, wherein an evaluation of toxicity of a specimen is performed on the basis of its toxicity to an established cell...

20060073468 - Genetically modified cyclic-nucleotide controlled ion channels and the use thereof: The present invention relates to genetically modified cyclic nucleotide-gated ion channels whose subunits have been altered so as to have higher sensitivity to cAMP and/or higher selectivity for cAMP compared to cGMP in comparison with the wild type according to SEQ ID NO 1 and 2....

20060073470 - Method of counting microorganisms or cells: A method of counting microorganisms or cells in a sample by labeling the microorganisms or cells with a fluorescent labeling reagent, which comprises contacting the sample containing the microorganisms or cells with an adhesive sheet having an adhesive layer laminated on at least one surface of a substrate to capture...

20060073471 - Method of using molecularly imprinted polymers for noninvasive diagnosis: The invention outlines a method for using Molecularly Imprinted Polymers (MIP's) in conjunction with specific, narrow wavelength light sources to non-invasively test for disease precursors. The invention makes it possible for a real time analysis to be carried out on the human body with minimal effort and greater efficiency than...

20060073469 - Methods and compositions for monitoring cell migration and identifying clinically relevant cytotoxic t lymphocyte activity: A three-dimensional reconstruct model containing solid layers of collagen and fibroblasts closely mimic the condition of patients in vivo, preserving in vivo phenotypic and functional characteristics of the cells. Reconstructs can be used to detect cellular migration, including active migration of cytotoxic T lymphocytes towards tumor cells, which can be...

20060073508 - Alpha-2 adrenergic receptor polymorphisms: The present invention includes polymorphisms in nucleic acids encoding the alpha-2B, alpha-2A, and alpha-2C adrenergic receptor and expressed alpha-2B, alpha2A and alpha-2C adrenergic receptor molecule. The invention also pertains to methods and molecules for detecting such polymorphisms. The invention further pertains to the use of such molecules and methods in...

20060073477 - Altered dna synthesome components as biomarkers for malignancy: Antibodies which specifically bind to components of the DNA synthesome which are altered in malignant cells are disclosed. These antibodies can be used, inter alia, to diagnose, prognoses, and treat malignancy and in assays to screen cells, tissues, and body fluids for the presence of a malignant phenotype. These antibodies...

20060073482 - Analysis of biological samples: The invention provides a method of analysing a biological sample of interest by use of: i) a probe library which comprises cDNA (or a derivative thereof) representative of a pattern of multiple gene expression in the biological sample of interest; and ii) a plurality of individual reference samples (preferably provided...

20060073491 - Apparatus and method for multiplex analysis: The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and...

20060073502 - Apparatus for detecting bio-bonding and method thereof: An apparatus and method for detecting a bio-bonding includes monitoring of a change of an electrical property before and after bio-bonding. The apparatus includes a signal transducer section having a substrate, a metallic thin film stepped on a surface of a certain region of the substrate, probe biomolecules formed on...

20060073478 - Atlastin: The present invention relates to methods and compositions of a novel gene and the peptide encoded by the gene. Mutations in the gene, named atlastin, are factors in the disease Hereditary Spastic Paraplegia and related disorders. The present invention will be used for the in the research, diagnosis and treatment...

20060073475 - Compositions and methods for detecting pathogenic bacteria expressing chaperonin proteins: This invention relates generally to compositions and methods for detection of pathogenic bacteria that express extracellular chaperonin proteins. In one embodiment, it relates to Mycobacterium tuberculosis (Mtb) detection and provides for novel probes for a specific and sensitive diagnostic test for Mycobacterium tuberculosis complex (TBC) that hybridize with the groEL-1...

20060073480 - Diagnostic and therapeutic use of vault polynucleotides and proteins for neurodegenerative diseases: The present invention discloses the differential expression of the minor vault protein ADPRTL1 gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating Alzheimer's disease in a subject, or for determining whether a subject is at increased risk...

20060073483 - Electro-optical nucleic acid-based sensor array and method for detecting analytes: The present invention is directed to methods of detection, identification and monitoring of vapor phase analytes by using sensor arrays comprising fluorophore labeled nucleic acids, dried onto a substrate which react with vapor phase analytes. Methods of using and preparing such sensor arrays are also provided....

20060073494 - Electronic hybridization assay and sequence analysis: An electronic hybridization assay implements a hybridization reaction, or a sequence analysis, on sequences representative of the sequences of the molecules under examination to provide an output representative of a chemical hybridization reaction. An electronic hybridization machine implements a correlation algorithm where the correlation output provides information regarding the relationship...

20060073490 - Enzyme-based device for environmental monitoring: A sensor for the intermittent or continuous detection of the presence of at least one analyte in an environmental sample includes at least one enzyme that is selected to either (i) catalyze a reaction of the analyte to chemically convert the analyte to a product compound or (ii) be inhibited...

20060073481 - Formation and use of site specific nucleic acid coupled binding polypeptides: The present invention provides methods of covalently attaching a nucleic acid to a specific site on a binding polypeptide non-enzymatically. The methods produce large quantities of site specific nucleic acid coupled binding polypeptides. The site specific nucleic acid coupled binding polypeptides are used in accurate and sensitive methods for detecting...

20060073512 - Genomic sequence of the purh gene and purh-related biallelic markers: The invention concerns the genomic sequence of the purH gene. The invention also concerns biallelic markers of a purH gene and the association established between these markers and cancer, particularly prostate cancer. The invention provides means to determine the predisposition of individuals to cancer as well as means for the...

20060073498 - Glcnac phosphotransferase of the lysosomal targeting pathway: The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme....

20060073507 - In vivo incorporation of alkynyl amino acids into proteins in eubacteria: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate alkynyl amino acids such as para-propargyloxyphenylalanine into proteins produced in a eubacteria host such as E. coli. The invention provides novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing...

20060073497 - Juvenile hemochromatosis gene (hfe2a) cleavage products and uses thereof: Isolated fragments of the HFE2A protein able to bind and modulate HFE2A and other proteins, such as hepcidin, involved in the iron metabolism pathway are disclosed, such fragments being of molecular weight of approximately 7 kDa to 43 kDa. Also disclosed are corresponding isolated polynucleotides encoding the fragments of the...

20060073485 - Mass defect labeling for the determination of oligomer sequences: Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for discriminating tagged molecules and fragments of molecules from chemical noise in the mass spectrum. These mass tagging methods are useful for oligomer...

20060073503 - Method and apparatus for analyzing nucleic acid amplification: There is provided a method of detecting or analyzing nucleic acid with a high reliability and reproducibility, capable of sampling target nucleic acid from initial target nucleic acid having not less than two types of sequences different from each other in a ratio which is proportional to that of initial...

20060073488 - Method and standards for detecting binding to an array: The present invention relates to methods for detecting, quantitating, or standardizing binding to a nucleic acid array, standard polynucleotides that can be used in such methods, compositions including the standard polynucleotides, and methods of making the standard polynucleotides. An aspect of the present invention relates to a complete exon transcript...

20060073509 - Method for detecting and quantitating multiple subcellular components: A method for detecting and quantitating multiple and unique fluorescent signals from a cell sample is provided. The method combines immunohistochemistry and a fluorescent-labeled in situ hybridization techniques. The method is useful for identifying specific subcellular components of cells such as chromosomes and proteins....

20060073495 - Method for inspecting quality of sensor chip, sample evaluating method, dna chip, and protein chip: A method for inspecting a quality of a sensor chip using either of (1) and (2) indicated below as a judgment index is provided: (1) interrelations of a plurality of circadian rhythm control genes in respect of expression level thereof; and (2) time-lapse patterns of specified circadian rhythm control genes...

20060073493 - Method of sequencing a genome: A method and computer-program product for sequencing nucleic acid sequences using restriction fragment maps derived from end-sequenced nucleotide fragments. The initial nucleotide sequence can be processed to form a shot-gun-data set. The present teachings employ a technique called Restriction Site Shotgun Sequencing (RSSS.) It can reduce the amount of overlap...

20060073484 - Methods and apparatus for pathogen detection and analysis: Methods and apparatus for implementing microfluidic analysis devices are provided. A monolithic elastomer membrane associated with an integrated pneumatic manifold allows the placement and actuation of dense arrays of a variety of fluid control structures, such as structures for isolating, routing, merging, splitting, and storing volumes of fluid. The fluid...

20060073474 - Methods and compositions for detecting the activation state of multiple proteins in single cells: The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of coordinately modulating the activity of a plurality of proteins in single cells. The...

20060073500 - Methods and compositions for rna amplification and detection using an rna-dependent rna-polymerase: Methods and compositions are provided for amplifying RNA from an RNA template. Methods and compositions are further provided for detecting an RNA in an RNA containing sample. Compositions used for the amplification of RNA from RNA include a RNA-dependent RNA-polymerase, a RNA helicase, and an energy source. Illustrative RNA-dependent RNA-polymerase...

20060073511 - Methods for amplifying and analyzing nucleic acids: The present invention provides methods for reducing the complexity of a nucleic acid sample to interrogate a collection of target sequences. Complexity reduction can be accomplished by annealing one or more target-specific primers to a nucleic acid sample containing genomic DNA and elongating the primers using a DNA polymerase with...

20060073506 - Methods for identifying biological samples: The present invention provides methods for marking nucleic acid samples with detectable markers by adding different combinations of marker molecules to each sample. Each sample may be marked with a different combination of two or more marker molecules each carrying a different tag nucleic acid sequences. The tag nucleic acid...

20060073501 - Methods for long-range sequence analysis of nucleic acids: Provided are methods for sequencing a target nucleic acid by fragmenting a target nucleic acid, hybridizing fragments to an array of capture oligonucleotides, determining the mass of the hybridized fragments, and constructing a nucleotide sequence of the target nucleic acid from the mass measurements....

20060073496 - Methods of identifying patients at risk of developing encephalitis following immunotherapy for alzheimer's disease: The present invention generally relates to a method for an improved treatment for Alzheimer's disease (AD) using immunotherapy, e.g., immunotherapy targeting β amyloid (Aβ), e.g., immunotherapy based on AN1792. In one embodiment, the method allows for predicting an adverse clinical response, and therefore allows for an improved safety profile of...

20060073486 - Multiple array substrates and methods for using the same: Multiple array substrates and methods for their use are provided. A feature of aspects of the invention is that the arrays of the multiple array substrate include a control set of probe nucleic acids that provides for the opportunity to screen for at least one of cross contamination among arrays...

20060073513 - Multiplex decoding of array sensors with microspheres: The invention relates to compositions and methods for multiplex decoding of microsphere array sensors....

20060073489 - Nanopore separation devices and methods of using same: The invention relates to nanopore-based separation devices and systems, and methods and kits for using these. The devices may be used to separate and evaluate biopolymers such as nucleic acids and proteins....

20060073499 - Nucleic acid adsorbent; methods for adsorbing, removing, dissociating, and recovering nucleic acids using the same; and method for regenerating the same: wherein R1 represents hydrogen, fluoride, or methyl; R2 and R3 each independently represent alkyl of 1 to 6 carbon atoms; A is —NH— or —O—; and B represents alkylene of 2 to 18 carbon atoms. Nucleic acids are recovered from cell extract by allowing them to be adsorbed to the...

20060073505 - Oligomeric compounds effecting drosha-mediated cleavage: The present invention provides methods of promoting Drosha-mediated cleavage of antisense oligomeric compounds and compositions and compounds for carrying out the same....

20060073510 - Polycationic polymer coatings for immobilizing biological samples: The present invention is directed to a pre-coated substrate, such as a slide, that is useful for immobilizing a sample. The invention is further provides methods of preparing such pre-coated substrates and methods of analyzing biological samples immobilized on such pre-coated substrate. The substrate is coated with a polycationic polymeric...

20060073492 - Prediction and predisposition of mbl gene to bronchial asthma with allergic rhinitis: The present invention relates to detection of allelic variants of MBL gene useful for prediction of predisposition to bronchial asthma with allergic rhinitis. The invention also provides for detecting allelic variants in MBL gene and their use in diagnosis and prediction of an individual's susceptibility to bronchial asthma with allergic...

20060073476 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073479 - Single nucleotide polymorphisms and combinations thereof predictive for paclitaxel responsiveness: Single nucleotide polymorphisms (SNPs) and combinations of SNPs that allow an inference as to whether a cancer patient is likely to respond or not respond to paclitaxel (Taxol®) are provided. Also provided are methods of determining a whether a cancer patient should be treated with paclitaxel....

20060073487 - System and method for inhibiting the decryption of a nucleic acid probe sequence used for the detection of a specific nucleic acid: Sequence-specific nucleic acid hybridization assays are used for the detection of specific genetic sequences as indicators of genetic anomalies, mutations, and disease propensity. In addition, they are used for the detection of various biological agents and infectious pathogens. Because a complementary probe or nucleic acid sequence is required to detect...

20060073504 - Treatment of pain by inhibition of caspase signaling: Pain, for example, neuropathic pain such as peripheral neuropathic pain, may be treated or alleviated by administering to a subject an effective amount of one or more caspase inhibitors. Activator and effector caspases, defining components of programmed cell death (PCD, apoptosis) signaling pathways, have been found to also contribute to...

20060073519 - Antibody specific to interleukin 18 precursor: Disclosed are an antibody specific to interleukin 18 (IL-18) precursor, preparation processes therefor, and uses thereof. The antibody includes immunoglobulins in both forms of polyclonal and monoclonal antibodies which exhibits an immunoreactivity against IL-18 precursor at an intensity higher than against other substances. The antibody is useful in detection and...

20060073522 - Fluorescently labeled growth hormone secretagogue: The present invention relates to a fluorescently labeled growth hormone secretagogue which can be used for the identification of compounds capable of binding to growth hormone secretagogue receptors, in particular by high throughput screening....

20060073515 - Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same: Human Edg4 and Edg5 polypeptides and their respective amino acid and nucleic acid sequences are provided for use in investigating cytoprotection, apoptosis, cellular proliferation, and other biological pathways in which phospholipid mediators are implicated....

20060073521 - Method for forming a film by spin coating: It is an object of the present invention to provide a method for producing a solid substrate used for sensors having a film with a small film thickness distribution, and a solid surface used for sensors having a film with a small film thickness distribution. The present invention provides a...

20060073518 - Method for selecting a candidate drug compound: The invention relates to the field of candidate drug testing and drug development. A method is provided for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a...

20060073514 - Methods of therapy and diagnosis using insulin-like growth factor binding protein-like polypeptides and polynucleotides: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted IGFBP-like polypeptides, compositions, and methods of use for such polypeptides including in...

20060073516 - Novel screening method: Using a novel G protein-coupled receptor protein having an amino acid sequence which is the same or substantially the same amino acid sequence as an amino acid sequence represented by SEQ ID NO: 2 or its salt together with β-alanine or L-carnosine, an agonist or an antagonist to the receptor...

20060073517 - Post-translational modifications of proteins as regulatory switches: The present invention relates to the generation of antibodies that bind to specific modifications of the amino terminus of histone H3 and the carboxy terminus of the H2A and H2B peptides. More particularly, the present invention is directed to the generation of a set of antibodies that recognize various post-translational...

20060073520 - Specific antibody directed to active hepatocyte growth factor activator and method for using the same: An antibody which recognizes an active hepatocyte growth factor activator (HGFA) and does not substantially recognize inactive HGFA is provided. Also disclosed is a monoclonal antibody thereof, and a hybridoma cell line for producing the monoclonal antibody. There is further provided a method for measuring active HGFA using the antibody,...

20060073523 - Detecting cell membrane protein endocytosis: Methods and reagents are provided for determining endocytosis, using a cell expressing an externally polypeptide labeled cell membrane receptor, and as a reagent an antibody to said label conjugated to a fragment of an enzyme fragment complementation pair. Compounds are tested for their effect on endocytosis by complexing the reagent...

20060073524 - Definitive diagnosis of epm in the horse: The present invention concerns detection of acute, chronic, or sub-acute equine protozoal myeloencephalitis by detecting antibodies in serum or CSF or the lymphoblastogenesis response to a recombinant protein that is folded in a conformationally correct state and is the immunodominant surface antigen of Sarcocystis neurona....

20060073526 - Antibodies, assay method by using them and judgment method for pancreas cancer: An antibody which specifically binds to carboxypeptidase A1 (CPA1) and procarboxypeptidase A1 (PCPA1), an antibody which specifically binds to carboxypeptidase A2 (CPA2) and procarboxypeptidase A2 (PCPA2), an antibody which specifically binds to PCPA1, and an antibody which specifically binds to PCPA2, and a hybridoma which produces a monoclonal antibody thereof,...

20060073529 - Luciferyl peptide substrate: Provided are luciferyl peptide substrates that are produced by attaching specifically prepared peptide conjugates to luciferin, and/or its analogs and derivatives. The luciferyl peptide substrates are incapable of penetrating cell membranes and tissue barriers. Cleavage of the peptide conjugates from the luciferyl peptide substrates releases the luciferin, which upon contact...

20060073528 - Measurement methods: The invention relates to methods for measuring unconjugated molecules, e.g. antibodies, in a mixture that also includes conjugated molecules, e.g. antibodies....

20060073525 - Methods for detecting breast and ovarian cancer: Kallikrein 5 constitutes a novel biomarker for diagnosis, treatment and monitoring of breast and ovarian cancer. A method is provided for diagnosing and monitoring breast or ovarian cancer or a predisposition to breast or ovarian cancer, in a subject comprising detecting kallikrein 5 in a sample from the subject. Imaging...

20060073527 - Using plasma proteomic pattern for diagnosis, classification, prediction of response to therapy and clinical behavior, stratification of therapy, and monitoring disease in hematologic malignancies: The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of...

20060073531 - Anti-chlamydial antibodies and uses thereof: The invention relates to anti-chlamydial antibodies and uses of anti-chlamydial antibodies for detection of the presence of chlamydia....

20060073530 - Methods and compositions involving sortase b: The present invention provides methods and compositions involving sortase-transamidases, including sortase B, and polypeptides that include a signal sorting sequence of NPQ/KTN/G. Methods of screening for inhibitors of Gram-positive bacteria as well as therapeutic, preventative, and research methods focusing on Gram-positive bacteria are also provided....

20060073532 - Detection of analytes using reorganization energy: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process....

20060073536 - Immunoassays for determining vitamin b12, and reagents and kits therefor: Methods are described for the development of monoclonal antibodies to intrinsic factor and the application of said antibodies in the development of B12 immunoassays. In particular, antibodies are described that are capable of binding to intrinsic factor only in the absence of vitamin B12, and that are released from binding...

20060073534 - Method for cleaving and deglycosylating antibodies to promote ligand binding: The present invention details methods to detect glycoproteins in samples to identify a disease state. In particular, an improved sandwich assay is described, using both an antibody and an array of lectins. Methods for increasing the efficiency of interaction of an antibody with a ligand by cleaving the antibody to...

20060073535 - Methods and kits for measuring adamts13/fxi complexes: Provided are assays and kits to detect ADAMTS13 activity using peptide substrates and ADAMTS13/Factor XI complexes using ELISA. These assays and kits can be used for diagnostic applications and to evaluate treatment of thrombotic thrombocytopenic purpura (TTP). Also provided is a novel form of ADAMTS13 found on platelets....

20060073533 - Production of ugppase: What are disclosed are a purified novel enzyme protein, UGPPase, which naturally occurs in animal cells, its production by means of recombinant technology, an antibody to the enzyme protein, a method of carrying out ELISA for measurement of the amount of UGPPase in an analyte and a method for determination...

20060073537 - Reagent system and process for adenosine triphosphate monitoring: A reagent system comprises a first reagent which includes a high pH phosphate buffer, and a second reagent which includes luciferase, luciferin, a magnesium salt and an enzyme stabilizer. The second reagent has a low pH and a buffer with a pK which is near the optimum pH for activity...

20060073538 - In-vitro diagnostic medical devices for determining saliva volume: The invention relates to a method of collecting saliva from the oral cavity for detecting a test substance, comprising the steps of (a) cleaning the oral cavity, (b) stimulating saliva secretion with a saliva-collecting solution, (c) removing the saliva-saliva collecting solution mixture from the oral cavity and collecting it in...

20060073539 - Apparatus and methods for using biological material to discriminate an agent: An apparatus and methods for using biological material to discriminate an agent. In one embodiment of the present invention, the method includes the steps of providing at least one cell, exposing at least one cell to an agent, measuring the response of the cell to the agent in terms of...

20060073540 - Method and system for controlling micro-objects or micro-particles: Moving components with dimensions much smaller than what micro-electro-mechanical system (MEMS) technology can accomplish in terms of force generated and power efficiency, are integrated onto micro-systems. These moving components referred to herein as “bio-components” are special bacteria (magnetotactic bacteria) where the motion of these bio-components can be controlled by generating...

20060073541 - Lipophilic dyes and their application for detection of myelin: Embodiments of the present invention provide a method for selectively detecting myelin in tissue samples using lipophilic dyes and kits for detecting myelin in a sample. The dyes of the present invention are represented by the general formula A-B-E wherein A is a nitrogen heterocycle, B is a bridge moiety...

20060073543 - Process for the preparation of angiotensis converting enzyme (ace) inhibitors and its use: Process for the preparation of angiotensis converting enzyme(ace)inhibitors and use thereof...

20060073542 - Recombinant glycosyltransferase fusion proteins: This invention provides recombinant glycosyltransferase fusion proteins having a desired level of expression and enzymatic activity (for example, acceptor substrate specificity or catalytic activity). The fusion proteins of the invention have a functional domain of a first glycosyltransferase joined, directly or through a peptide linker, to a subsequence of a...

20060073561 - 157 human secreted proteins: The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors,...

20060073566 - Active modified hedgehog proteins: The present invention provides isolated highly active hedgehog proteins esterified with a fatty acid having from 14 to 20 carbon atoms at the N-terminal domain of the protein. The highly active hh proteins are particularly useful therapeutic agents for treating bone disorders and neurodegenerative diseases. Methods for obtaining the highly...

20060073570 - Apo-2 receptor: Novel polypeptides, designated Apo-2, which are capable of modulating apoptosis are provided. Compositions including Apo-2 chimeras, nucleic acid encoding Apo-2, and antibodies to Apo-2 are also provided....

20060073559 - Ehanced protein expression in bacillus: The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the present invention relates to Gram-positive microorganisms, such as Bacillus species having enhanced expression of a protein of interest, wherein one or more chromosomal genes have been inactivated, and...

20060073563 - Erythropoietin derivatives with altered immunogenicity: The present invention relates to novel erythropoietin protein variants with altered immunogenicity....

20060073567 - Novel insulin/igf/relaxin family polypeptides and dnas thereof: The present invention relates to (1) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO:7 (A chain), (2) a polypeptide containing the same or substantially the same amino acid sequence as the amino acid sequence represented by...

20060073565 - Novel nucleic acid molecules encoding opioid growth factor receptors: This invention relates to novel nucleic acid molecules coding for opioid growth factor receptors. In particular, the present invention provides isolated nucleic acid molecules coding for human and rat OGF receptors. Antisense molecules, expression vectors and host cells, isolated proteins encoded by such nucleic acid molecules, antibodies directed against such...

20060073564 - Nucleic acid molecule encoding a (poly)peptide co-segregating in mutated form with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (apeced): The present invention relates to a nucleic acid molecule encoding a (poly)peptide co-segregating in mutated form with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED). In addition, the invention relates to a mammalian, preferably murine, homologue of the above nucleic acid molecule. The present invention further relates to a nucleic acid molecule...

20060073551 - Pro4487 polypeptides: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073562 - Protein tyrosine kinase substrate lat and its use in the indentification of (ant)agonists of the kinase: The invention generally relates to compositions and methods for identifying and testing tyrosine kinase signaling pathway agonists and antagonists, and more particularly, methods and compositions for screening compounds and identifying compounds that will modulate the interaction of protein tyrosine kinase substrates with their intracellular ligands, as well as between their...

20060073544 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073545 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and hostcells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of...

20060073546 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073547 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073548 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073549 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073550 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073552 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073553 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073554 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073555 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073556 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073557 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073558 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073568 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073560 - Selective expression in filamentous fungi: Gene promoters activated only during development of the fruiting body of filamentous fungi permit expression of large quantities of heterologous genes, even where such are otherwise toxic to the organism....

20060073569 - Von willebrand factor (vwf) - cleaving protease: This invention is intended to isolate and identify a vWF-specific cleaving protease. The vWF-specific cleaving protease cleaves a bond between residues Tyr 842 and Met 843 of vWF and comprises a polypeptide chain having Leu-Leu-Val-Ala-Val (SEQ ID NO: 1) as a partial sequence, and more preferably comprises a polypeptide chain...

20060073571 - Recombinant bifunctional protein of human lutropin receptor and human chorionic gonadotropin b-subunit and uses thereof: The present invention relates to a chimeric nucleic acid molecule encoding a fusion protein having a human lutropin hormone-receptor domain and a human chorionic gonadotropin-β subunit domain, the isolated human lutropin hormone-receptor/human chorionic gonadotropin-β fusion protein, and antibodies which recognize part or all the domains of the fusion protein. Also...

20060073573 - Chemotactic cytokine iii: Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists...

20060073572 - Cytokine structurally related to il-17: The cytokine ML-1 is a target for treating airway inflammation. Candidate therapeutic agents for treating airway inflammation can be screened for the ability to bind to an ML-1 protein or polynucleotide, from the ability to decrease functional properties of ML-1, or for the ability to decrease ML-1 gene expression. Pharmaceutical...

20060073574 - Engineered biosynthesis of novel polyenes: The complete DNA sequence of the gene cluster encoding the polypeptides responsible for the biosynthesis of the polyene antibiotic amphotericin of S. nodosus is provided. Engineered alteration of the amphC) gene so as to eliminate production of amphotericin A in favour of the more active form amphotericin B. as well...

20060073575 - Methods and reagents for assaying protein kinase activity: A kit of parts comprising two or more protein kinase substrate polypeptides, each said substrate polypeptide comprising a specificity conferring portion (which is different for each said kinase substrate polypeptide) and a phosphorylatable portion, wherein the phosphorylatable portions of each polypeptide are capable of being bound in a phosphorylation state-sensitive...

20060073576 - Hiv envelope-cd4 complexes and hybrids: Env-CD4 complexes and hybrids are disclosed that expose cryptic epitopes that are important in virus neutralization. Methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided....

20060073577 - High succinate producing bacteria: The invention relates to a hybrid succinate production system that has a high capacity to produce succinate under aerobic and anaerobic conditions. The metabolic engineering of a hybrid bacterial succinate production system that can function under both aerobic and anaerobic conditions makes the production process more efficient, and the process...

20060073578 - Process for producing unsaturated fatty acid-containing oils: An edible oil obtained by culturing a microorganism belong to the genus Mortierella subgenus Mortierella in a medium containing a nitrogen source derived from soybean is discussed. The oils obtained have a low 24,25-methylenecholest-5-en-3β-ol content....

20060073579 - Secreted and transmembrane polypeptides and nucleic acids encoding the same: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides...

20060073580 - Glucose dehydrogenase: Disclosed is a modified glucose dehydrogenase having pyrroloquinoline quinone as a coenzyme, wherein one or more amino acid residues in a region of amino acid 349-377 of water-soluble PQQGDH derived from Acinetobacter calcoaceticus is replaced with other amino acid residues and has an inhibition constant (Ksi) of 200 mM or...

20060073581 - Crystal structures of bacterial guanylate kinases: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention....

20060073582 - Rab9 protein crystal structures and methods for identifying rab9 modulators: The present invention relates to crystalline Rab9 in complex with either GDP or the GTP analog Guanosine 5′-(β,γ-imido) triphosphate (GppNHp), the three dimensional coordinates and structures of Rab9 in Rab9-GDP and Rab9-GppNHp complexes, and uses thereof for drug design. In particular, the present invention relates to methods for producing Rab9...

20060073583 - Polypeptide: We describe a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises an amino acid mutation at one or more positions selected from the group consisting of: 146, 157,...

20060073584 - Chemical analyzing apparatus: A chemical analyzing apparatus accommodates therein a structure for retaining a sample and reagents. A detecting mechanism detects the sample after reaction with a reagent. After or during extraction of a biological substance from the sample in the structure, a temperature of a fluid in a space around the structure...

20060073585 - Capture and detection of microbes by membrane methods: Methods and systems for detecting the presence of analytes using a membrane based detection system are described. A fluid sample is passed through a membrane based detection system (100). Particulate analytes (e.g., microbes) are captured by the membrane (110). Detection and analysis techniques may be applied to determine the identity...

20060073586 - Dna sequences encoding dystrophin minigenes and methods of use thereof: The present invention provides a series of novel dystrophin minigenes that retain the essential biological functions. The expression of the dystrophin minigenes may be controlled by a regulatory element along with a small polyadenylation signal. The entire gene expression cassettes may be readily packaged into a viral vector, preferably an...

20060073587 - Neuronal progenitors from feeder-free human embryonic stem cell culture: The present invention relates to methods for producing feeder cell-free neuroprogenitor cells (preferably adherent) from embryonic stems cells, preferably human embryonic stem cells, the feeder cell-free neuroprogenitor cells, preferably human cells themselves, as well as methods for producing feeder cell-free samples of neuronal cells, preferably adherent human neuronal cells and...

20060073588 - Method for chondrocyte expansion with phenotype retention: The present invention provides a method that maintains chondrocyte phenotype during serial expansion by culturing a population of chondrocytes in a defined serum-free culture medium containing cytokines and on a substrate that is modified by covalent attachment of hyaluronic acid. The underlying principle is to maintain native chondrocyte phenotype by...

20060073589 - Rapid generation of activated mononuclear antigen presenting cells from monocytes: A cell population prepared from blood mononuclear cells, the mononuclear cells being peripheral blood mononuclear cells (PBMC) or CD 14+ monocytes, the population containing from about 10% to about 50% of activated mononuclear antigen presenting cells (APCs) having the following characteristics: • they express surface markers CD2, CD83 and CD14,...

20060073590 - Decellularized tissue engineered constructs and tissues: New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct by growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can be used...

20060073591 - Cell culture media: The invention is a cell culture medium that can include reduced or no serum and that enhances the performance of serum-free media for cell culture. The medium supports the growth of cells for both small scale and large scale propagation of cells. The invention also includes a method of cultivating...

20060073592 - Methods of storing tissue matrices: The invention provides methods of storing acellular tissue matrices in which a substantial portion of water in the matrices is replaced with a water-replacing agent, e.g., glycerol. Also included in the invention are compositions made by these methods as well as methods of treatment using such compositions....

20060073593 - Compositions and methods for molecular biology: The present invention provides materials and methods for the utilization of the specific interaction of replication termination sequences with their binding proteins in molecular biology applications....

20060073594 - Chimeric vectors: The present invention relates to chimeric vectors. More specifically, the invention relates to recombinant poxvirus vectors and viruses that are capable of expressing an alphaviral RNA replicon expressing a heterologous sequence of interest....

20060073595 - Regulation of adenovirus dna packaging by iptg: The present invention relates to recombinant Adenoviruses (Ad) which function as helper viruses to gutted Ad viruses lacking viral coding sequences. The recombinant Ad of the present invention comprise a binding site of the E. coli Lac repressor protein embedded within the packaging domain. Available Lac repressor protein binds to...

20060073596 - Methods and compositions for the inhibition of gene expression: The present invention relates to methods and compositions for the inhibition of gene expression. In particular, the present invention provides oligonucleotide-based therapeutics for the inhibition of oncogenes involved in cancers....

20060073597 - Highly controllable electroporation and applications thereof: The controllable electroporation system and method described herein allows control over the size, the number, the location, and the distribution of aqueous pores, thus increasing flexibility of use. The herein described system and method for controllable electroporation generally employs at least two actuating sub-systems and sub-processes. One sub-system and sub-process...