Chemistry: analytical and immunological testing inventions

20080108141 - Diaminorhodamine derivative: wherein, in the formula (I), R1, R2, R3, and R4 independently represent methyl group or ethyl group; and in the formula (II), R5, R6, R7, and R8 independently represent methyl group or ethyl group and X— represents an anion, and a reagent for measurement of nitric oxide which comprises said... Agent: Greenblum & Bernstein, P.L.C

20080108142 - Visual spill indicator: Composition which includes a dye (101) that changes color when contacted with a suitable amount of an organic substance, in conjunction with a matrix (103), past (102), support (104) or web (104), that indicates visually or photometrically the presence of the organic substance.... Agent: Christopoher John Rudy

20080108143 - Selection of particles in laminar flow: The invention relates to a method for selecting charged particles possessing a predetermined property from a population of a multiplicity of different particles, and also to a device which is suitable for implementing the method.... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080108144 - Method for the rapid analysis of polypeptides: The invention provides improved sample preparation techniques as will as improved methods of analysis of samples. The techniques include a method of preparing a sample of MALDI-TOF analysis comprising applying a material having a liquid component to a carrier, removing at least a portion of the liquid component, and applying... Agent: Dunlap Codding & Rogers, P.c.

20080108145 - Genes associated with osteoarthritis: A method of screening a small molecule compound for use in treating osteoarthritis, comprising screening a test compound against a target selected from the group consisting of the gene products encoded by ADAM15, ADAM23, ADAM30, C22ORF18, CACNB2, CTRL, LCAT, GPR75, MAOB, OPRL1, GPR8, PKD2L1, PTH, RAB3-GAP150, RARG, SHH, TBXA2R, TNK2,... Agent: Glaxosmithkline Corporate Intellectual Property

20080108146 - Flow cytometers: A calibration method for a flow cytometer with a multichannel detector module. During calibration, the fluorescence intensity data values for the different detector channels are used to calculate normalization factors needed to adjust subsequent data collected by each of the channels. By using a multichannel detector module, the results from... Agent: Foley And Lardner LLP Suite 500

20080108147 - Reduction of non-specific binding in immunoassays: Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample wherein one of the reagents for conducting the binding assay is an antibody reagent. The methods comprise treating the antibody reagent at a pH of about 2.0 to... Agent: Dade Behring Inc. Legal Department

20080108148 - Human salty taste receptor and methods of modulating salty taste perception: Methods for identifying modulators of the epithelial sodium ion channel and for identifying modulators of salty taste perception are described. Also featured are isolated human salty taste receptors, artificial lipid bilayers comprising an epithelial sodium ion channels, and kits for practicing the claimed methods.... Agent: Woodcock Washburn LLP

20080108149 - Solid-phase mediated synthesis of molecular microarrays: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived methods and electrochemically generated reagents. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides, polymers joined by peptide bonds, nucleic acids, and polymers... Agent: Intel/blakely

20080108150 - Systems and methods for molecular recognition: Acoustic wave devices coated with a biolayer are described for the detection target bio-molecules. The acoustic wave device is connected in an oscillator circuit, and the frequency shift Δf resulting from a biomolecular event is recorded. Further described are the use of Rayleigh wave surface acoustic wave devices for vapor... Agent: Perkins Coie LLP

20080108151 - Process for (a) separating biological ligands from dilute solutions and (b) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughout: Superparamagnetic (“SPM”) subunits of 1-30 nm average mean diameter (e.g. ferro fluid) subparticles are treated with a magnetically noninterfering substance capable of coating and covering them (e.g, BSA) and they spontaneously form agglomerates of about 100 nm to about 450 nm or higher average mean diameter and are then used... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080108152 - Methods for characterizing glycoproteins and generating antibodies for same: The invention provides methods for generating an antibody specific for the deglycosylated form of a glycopolypeptide using a peptide corresponding to an N-linked glycosylation site of a glycopolypeptide. The invention additionally provides methods for generating an antibody specific for a glycopolypeptide using a peptide corresponding to amino acids adjacent to... Agent: Mcdermott, Will & Emery

20080102525 - Novel standard reference solutions: Standard reference materials and related methods are described for quality testing and calibration of instruments used for the qualitative and quantitative determination of hemoglobin and glycated hemoglobin as well as other analytes of interest in animal tissue samples. The reference solutions of the disclosure utilize a synthetic cruor in combination... Agent: Mcdermott Will & Emery LLP

20080102528 - Automatic biochemical analyzing method and apparatus: An automatic biochemical analyzing method is described, in which a row of reaction containers is cyclically arrayed such that an operating cycle is formed that is defined between dispensing the preceding sample and the sequent sample. In each cycle, the reaction containers are transferred so as to motivate at least... Agent: Beyer Weaver LLP

20080102529 - Process for evaluating a refinery feedstock: The invention provides a process for evaluating the effect of a refinery feedstock on a refinery process, said process comprising (i) providing a refinery feedstock; (ii) treating said refinery feedstock to produce a plurality of fractions each representative of the typical feedstock for the refinery process of interest, said plurality... Agent: Nixon & Vanderhye, PC

20080102531 - Fingerprint analysis for a plurality of oligonucleotides: The invention provides a method for evaluating the accuracy of an oligonucleotide sample, specifically a sample containing a variety of oligonucleotides of potentially varying size and sequence. The method provides a fingerprint that can be used to evaluate the accuracy of a multi-oligonucleotide sample whether or not the sample contains... Agent: John Petravich Integrated Dna Technologies, Inc.

20080102526 - Reagent, reagent kit and analyzing method: A method for analyzing platelet is described. In the method, a measurement sample is prepared by mixing a sample and a dye for staining platelet. The dye is selected from the group consisting of Capri blue, Nile blue and brilliant cresyl blue. By irradiating cells in the measurement sample with... Agent: Sughrue Mion, PLLC

20080102527 - Method for introducing a fluid into a reaction receptacle contained within a temperature-controlled environment: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080102530 - Methods to radiolabel natural organic matter by reduction with hydrogen labeled reducing agents: Methods to radiolabel natural organic matter by reduction with a hydrogen labeled reducing agent, and compositions, are provided.... Agent: Dorsey & Whitney, LLP Intellectual Property Department

20080102532 - Handheld microcantilever-based sensor for detecting tobacco-specific nitrosamines: A method and system for detecting tobacco-specific nitrosamines. The method includes exposing at least one microcantilever beam to a medium, which may contain tobacco-specific nitrosamines, and measuring a deflection of the microcantilever beam, wherein the deflection indicates a presence of tobacco-specific nitrosamines in the medium. The at least one microcantilever... Agent: Buchanan, Ingersoll & Rooney PC

20080102533 - Apparatus and method for measuring specific heat using flash: The present invention relates to an apparatus and method for measuring specific heat using flash. To this end, the specific heat measurement apparatus includes sample fixing means for fixing a sample 50 so that each of both surfaces 52, 55 of the sample 50 is partially exposed, flash irradiation means... Agent: Patterson, Thuente, Skaar & Christensen, P.A.

20080102534 - Unsaturated dipyrromethene-boron borocarbons: The invention relates to unsaturated dipyrromethene-boron borocarbons of formula (I) and the use thereof for fluorescence or electroluminescent analysis. The fluorescent properties are provided by the central ring of six atoms comprising the —N—B—N— sequence, R1 to R7 permitting the modification of the compound properties (fluorescence emission wavelength, quantitative fluorescent... Agent: Young & Thompson

20080102535 - Measuring thyroxine levels from dried blood samples using mass spectrometry: Measuring thyroxine levels from dried blood samples using mass spectrometry. A test sample is provided that was obtained by treating a dried blood sample with an extraction solution. The test sample also includes an isotopically enriched thyroxine standard. The test sample is scanned using a mass spectrometer to produce one... Agent: Choate, Hall & Stewart LLP

20080102536 - Method of manufacturing an analytical sample and method of analyzing an analytical sample: A method of manufacturing an analytical sample by a secondary ion mass spectrometry method is provided, which comprises a step of forming a separation layer over a substrate, a step of forming one of a thin film and a thin-film stack body to be analyzed over the separation layer, a... Agent: Eric Robinson

20080102537 - Method of detecting analytes in a microfluidic sample and a system for performing the same: A method of detecting analytes in a microfluidic sample includes introducing at least one type of analyte, at least one type of carrier particle, and a fluid into a mixing chamber of a system. The at least one type of analyte binds to a site on the at least one... Agent: Hewlett Packard Company

20080096281 - Cyanide sensing compounds and uses thereof: The present invention relates to a cyanide detection method using fluorescence and cyanide sensitive boronic acid containing fluorophores, wherein a change in a measured fluorescent property correlates to the concentration of the cyanide compound in a biological or environmental test sample.... Agent: Moore & Van Allen PLLC

20080096282 - Spectrophotometic analysis of plasma in a closed-container: The present invention provides a method of analyzing plasma from a sample of whole blood comprising a) obtaining a sample of whole blood from a subject in a container, the container comprising a first end and a second end, the first end of the container for receiving a sample of... Agent: Quarles & Brady LLP

20080096280 - Method of assaying the antioxidant activity of oils: A method of assaying the antioxidant activity of a range of plant, animal or synthetic oils and other similar substances in a liquid phase. The method consists in forming an oil-in-water emulsion with a surfactant, adding an ethene generator substrate and an oxidative peroxyl radical solution and measuring the ethene... Agent: D. Peter Hochberg Co. L.p.a.

20080096283 - Methods for detection of breast cancer: The invention relates to a simple screening test for neoplasia, a precancerous condition, or cancer of the breast. A method is described whereby a breast cancer marker is detected in breast fluid. In a particular embodiment, the method involves treating samples of breast fluids with an aldehyde detecting reagent without... Agent: Merchant & Gould PC

20080096284 - Protein separation and analysis: The present invention relates to multi-phase protein separation methods capable of resolving and characterizing large numbers of cellular proteins, including methods for efficiently facilitating the transfer of protein samples between separation phases. In particular, the present invention provides systems and methods for the differential display of protein samples from multiple... Agent: Casimir Jones, S.c.

20080096285 - Method for automatic determination of sample: A method of determining a kind of a sample, in a method for analyzing a substance by the steps of supplying the sample to be analyzed to a reaction system by a supplying means comprising a transparent region composed of a transparent material, reacting a reagent for detecting the substance... Agent: Heslin Rothenberg Farley & Mesiti PC

20080096286 - Biopolymer marker indicative of disease state having a molecular weight of 1348 daltons: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their... Agent: Mchale & Slavin, P.A.

20080096287 - Nanoscale moiety placement methods: Methods and structures for placing nanoscale moieties on substrates are provided.... Agent: Agilent Technologies, Inc. Legal Department, Dl429

20080096288 - Membrane-based assay devices: A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes... Agent: Dority & Manning, P.A.

20080096289 - Core-shell nanoparticles for detection based on sers: A nanoparticle having a self assembly monolayer of molecules as a shell on the nanoparticle. The monolayer may include organic molecules working as surface enhanced Raman spectroscopy (SERS) reporters. Also, the core shell may include at least a receptor, and/or the like, to ensure that a target analyte can be... Agent: Honeywell International Inc.

20080090296 - Method for the determination of the oxidative stability of a lubricating fluid: P

20080090297 - Methods for determining the metal bioavailability of metal sources: The invention provides methods for determining the relative metal bioavailability of a metal source in an animal or group of animals. The method may be utilized to compare the relative metal bioavailability between different metal sources and it may be used to determine the relative nutritional status of a metal... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080090298 - Method and system for identification of protein-protein interaction: A method for the characterization of protein-protein interactions based on diagonal mass spectrometry is provided. Proteomic samples containing interacting proteins are chemically crosslinked either in vivo or in vitro. After a high resolution chromatographic separation, crosslinked interacting proteins are introduced directly into a mass spectrometer. During the data acquisition, the... Agent: Agilent Technologies Inc.

20080090299 - Method and system for identification of protein-protein interactions: A method for rapid detection and possibly identification of protein complexes is disclosed. The method utilizes a two stage high resolution chromatographic analysis and a reversible crosslinker to detect and identify protein complexes. The identification of protein complexes may be further improved by mass spectrometry analysis of chromatographic fractions containing... Agent: Agilent Technologies Inc.

20080090301 - Method to detect adulterated specimens: The invention is a method to detect adulterated specimens submitted for substance abuse. It is concerned with testing a sample of the submitted urine, and in a parallel test analyze a sample of the submitted urine to which has been added known amount of the suspected substance. A control artificial... Agent: William M. Selenke

20080090295 - Method and device for preparing an analyte for analysis by mass spectrometry: The invention provides methods and apparatus for automated sample preparation for MALDI-TOF MS using columns in combination with a liquid handling system. The samples are typically biological such as serum or urine. The columns typically include a bed of media positioned within a modified pipette tip. In some embodiments, the... Agent: Phynexus, Inc.

20080090300 - Detection of gleevec resistant mutations: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for... Agent: Klarquist Sparkman, LLP

20080090302 - Method for prediction of high frequency reciprocating rig wear scar diameter for hydrocarbon mixtures: A method is disclosed for predicting the High Frequency Reciprocating Rig (HFRR) wear scar diameter for a hydrocarbon mixture using an HFRR wear scar diameter prediction equation which predicts the HFRR wear scar diameter based on the mid-infrared spectroscopy test results for such hydrocarbon mixture. Such predicted HFRR wear scar... Agent: Conocophillips Company - I.p.legal

20080090305 - Device for detection of molecules in biological fluids: Disclosed is a test device and a method for qualitatively and/or quantitatively measuring the concentration of an analyte in a biological fluid sample. The test device includes a housing defining a sample port, a test well containing a stirrer and a conjugate, and a test strip disposed within the housing.... Agent: Fay Sharpe LLP

20080090304 - Diagnosis and monitoring of chronic renal disease using ngal: A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as... Agent: Hasse & Nesbitt LLC

20080090303 - Methods and reagents for detecting bioactive lipids: Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate)... Agent: Biotechnology Law Group C/o Portfolioip

20080090306 - Method for immobilizing biomolecules: An object of the present invention is to provide a method for preventing the generation of negative signals because of dissociation of a ligand from a surface and improving the precision of signals indicating binding between a ligand and an analyte. The present invention provides a method for immobilizing a... Agent: Sughrue Mion, PLLC