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Chemistry: analytical and immunological testing February patent applications/inventions, industry category 02/11

20110045595 - Method and device for dosing and mixing small amounts of liquid: A method or device for integrated dosing and intermixing of small amounts of liquid, has at least one dosing reservoir (3) connected to a reaction reservoir (1) via at least one joining structure (11) and entirely filled with a first liquid. The at least one joining structure (11) is preferably... Agent: Townsend And Townsend And Crew LLP

20110045596 - Process and installation for testing catalysts: m

20110045597 - Chemical sensors of zinc, nickel, and copper ions: The present technology provides a dual chemical sensor for zinc and nickel ions and a chemical sensor for copper ions. Also provided are methods of making and using the chemical sensors. The chemical sensors have the structure of formula I, wherein R1, and R2 are defined as set forth herein.... Agent: Foley & Lardner LLP

20110045598 - Methods for determining enantiomeric purity with improved chiral selectors: A strategy, or method, for the quantitative determination of enantiomeric purity that combines lin situ enantiomer diastereomerization', spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multivariate regression modeling known as partial least squares (“PLS-I”) regression. The PLS-I regression produces a... Agent: Jackson Walker LLP

20110045599 - System and method for regulating flow in fluidic devices: Disclosed are a system and method for regulating flow in an exemplary fluidic device comprising a fluidic stream carrying a transport medium, sample and one or more reagents for analysis and synthesis of reaction products. The flow rate of the fluidic stream is maintained constant by adjusting the flow rate... Agent: Andrews Kurth LLP

20110045600 - Oxygen and carbon dioxide sensing: A high electron mobility transistor (HEMT) capable of performing as a CO2 or O2 sensor is disclosed, hi one implementation, a polymer solar cell can be connected to the HEMT for use in an infrared detection system. In a second implementation, a selective recognition layer can be provided on a... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20110045601 - Organic chemical sensor comprising microporous polymer, and method of use: Applicant discloses a sensing element for sensing an organic chemical analyte, comprising a first electrode and a second electrode, and a microporous, hydrophobic, analyte-responsive dielectric material disposed at least in proximity to the first and second electrodes. The analyte-responsive dielectric material may be a polymer of intrinsic microporosity. An electrical... Agent: 3m Innovative Properties Company

20110045605 - Characterization of granulocytic ehrlichia and methods of use: The present invention relates, in general, to granulocytic ehrlichia (GE) proteins. In particular, the present invention relates to nucleic acid molecules coding for GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins; purified GE S2, S7, S22, S23, C6.1, C6.2, S11, E8, E46#1, and E46#2 proteins... Agent: Jones Day

20110045606 - Method for detecting a target molecule in a biological sample: A method is provided for detecting a target molecule in a biological sample. One step of the method includes immobilizing the biological sample on a membrane. Next, the membrane-bound biological sample is contacted with at least one detection moiety. The membrane-bound biological sample is then separately mated with a substrate... Agent: Tarolli, Sundheim, Covell & Tummino L.L.P.

20110045604 - Molecular affinity clamp technology and uses thereof: The invention provides a molecular affinity clamp. The architecture of the affinity clamp is modular with two biorecognition modules, each capable of binding a target motif. The first biorecognition module has a recognition domain that possesses inherent or natural specificity for the target motif. The second biorecognition module also has... Agent: Fulbright & Jaworski L.L.P.

20110045603 - Serine, threonine, and tyrosine phosphorylation sites: The invention discloses 990 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20110045607 - Probe composite, method for manufacturing the same, method for using the same, and contrast agent including the same: A probe composite for photoacoustic imaging includes a first probe and the second probe mixed with each other. The first probe includes a first ligand and a first nanorod conjugated to the first ligand. The first ligand specifically interacts with a first target. The second probe includes a second ligand... Agent: North America Intellectual Property Corporation

20110045608 - Imatinib immunoassay: Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids.... Agent: Gibbons P.C.

20110039342 - Diagnostic markers of wound infection: A method of diagnosis or prediction of infection of a mammalian wound, said method comprising the step of detecting the presence of a cytokine selected from the group comprising procalcitonin, amino procalcitonin (N-ProCT), eotaxin, granulocyte macrophage colony stimulating factor (GM-CSF), interleukins IB monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1 alpha... Agent: Convatec Inc.

20110039341 - Method for detecting nucleotide polymor-phisms using semiconductor particles: A method for detecting anomalies in genetic material is provided, the method comprising supplying the genetic material; establishing electronic communication between the genetic material and a semi-conductor particle so as to create a composite; contacting the composite with a first metal ion; and subjecting the contacted composite to energy in... Agent: Michael J. Cherskov

20110039343 - Method for the identification of patients in need of therapy having minor cognitive disorders and the treatment of such patients: A method for the identification of patients in need of therapy and for the preventive treatment of such patients having minor cognitive disorders, wherein an increased risk can be determined for said patients to develop clinically manifested Alzheimer's disease during a preceding risk stratification as a result of an increase... Agent: Millen, White, Zelano & Branigan, P.C.

20110039344 - Method and testing a subject thought to be predisposed to lung cancer: The present invention concerns a method of testing a human thought to be predisposed to having lung cancer which comprises the step of analyzing a biological sample from said human for detecting the presence of a polymorphism on chromosome 15q25 associated with lung cancer.... Agent: Foley And Lardner LLP Suite 500

20110039345 - System and method for electrochemical detection of biological compounds: The present invention relates to an electrochemical method for detecting a target polynucleotide. An electrode comprising an electrode surface is provided. The electrode surface includes at least one probe molecule reversibly immobilized with respect to the electrode surface. A first electrochemical signal indicative of an amount of probe molecule immobilized... Agent: Knobbe Martens Olson & Bear LLP

20110039346 - Drug detection straw: The present invention relates to a drug detection device for detecting the presence of a date rape drug in a beverage comprising: a straw; and a chemical reagent, where said chemical reagent coats the surface of the straw and changes color upon contact with a date rape drug. In one... Agent: Law Office Of Jerry D. Haynes , P.a

20110039347 - Analytical method and apparatus: A method for determining the amount of a chemical species in a sample, in particular the amount of weak acid dissociable cyanide or total cyanide in a sample, and an apparatus for performing said method. The method comprises the steps of: i) treating the sample to liberate the chemical species... Agent: Swanson & Bratschun, L.L.C.

20110039348 - Method of evaluating reaction between dissolved hydrogen and dissolved oxygen and method of evaluating ability of dissolved hydrogen to scavenge active oxygen in water: Based on the temporal profile of the difference between the dissolved oxygen amount measured with forcibly dissolving hydrogen and the dissolved oxygen amount measured with blowing any other gas than hydrogen, the reaction between dissolved hydrogen and dissolved oxygen is quantitatively evaluated. Based on the temporal profile of the difference... Agent: Wenderoth, Lind & Ponack, L.L.P.

20110039350 - High yield atmospheric pressure ion source for ion spectrometers in vacuum: Gaseous analyte molecules are ionized at atmospheric pressure and provided to an inlet capillary of an ion spectrometer vacuum system by passing the ions through a reaction tube that ends in a conical intermediate piece for a gastight and smooth transition into the inlet capillary. The reaction tube is shaped... Agent: Paul E. Kudirka Law Offices Of Paul E. Kudirka

20110039349 - Sample testing apparatus, information management apparatus and sample testing method: A sample testing apparatus comprising: a receiving section which receives identification information inputted by an operator; a testing section which tests a sample to obtain a test result; a memory which stores the test result, which is obtained by the testing section, so as to be associated with the identification... Agent: Brinks Hofer Gilson & Lione

20110039351 - High temperature high pressure vessel for microwave assisted chemistry: A method of conducting microwave-assisted high pressure high temperature chemistry is disclosed. The method includes the steps of digesting a sample in a strong acid at a temperature of at least 200° C. in a pressure resistant vessel that includes a lid while exerting a defined force against the lid... Agent: Summa, Additon & Ashe, P.A.

20110039353 - Method for direct detection of ischemia-modified albumin using a partner for binding to an aldehyde derivative resulting from the peroxidation of lipids in bound form: The present invention relates to the use of at least one partner for binding to an aldehyde derivative resulting from the peroxidation of lipids in protein-bound form, for instance to 4-hydroxy-2-nonenal, to 4-hydroxy-2-hexenal or to malondialdehyde, for the detection of ischemia-modified albumin (IMA) in a biological sample.... Agent: Oliff & Berridge, PLC

20110039354 - Method of characterizing and quantifying calcifying nanoparticles: A method of characterizing calcifying nanoparticles (CNPs) can include creating a test sample comprising CNPs isolated from a biological source, a buffer solution, a plurality of calibration beads, and a fluorescent marker specifically linked to the CNPs; evaluating the test sample using a flow cytometer; and analyzing results from the... Agent: Gregory A. Nelson Novak Druce & Quigg LLP

20110039352 - Methods to measure dissociation rates for ligands that form reversible covalent bonds: The crystal structure of the ligand binding domain of ERR-α in complex with a ligand that forms a reversible thioether bond to Cys325 of ERR-α, methods to measure dissociation rates for ligands that form reversible covalent bonds, and methods to design ligands that form reversible covalent bonds for use as... Agent: Philip S. Johnson Johnson & Johnson

20110033939 - Method of measuring lipoarabinomannan and application thereof: A method for measuring LAM and a method for detecting an acid-fast bacterium, which comprise at least a step of allowing a Limulus reagent to contact with a LAM-containing sample; a method for removing reactivity of LAM with a Limulus reagent, which comprises at least a step of allowing a... Agent: Sughrue-265550

20110033940 - Click chemistry, molecular transport junctions, and colorimetric detection of copper: Click chemistry is used to construct molecular transport junctions (MTJs) through assembly of a molecular wire across a nanogap formed between two electrodes. Also disclosed are methods of using click chemistry and oligonucleotide-modified nanoparticles to detect the presence of copper in a sample.... Agent: Marshall, Gerstein & Borun LLP

20110033942 - Predicting renal failure in diabetes patients based on placental growth factor and soluble flt-1: Disclosed is a method for predicting the risk of developing renal failure or mortality for a subject suffering from diabetes mellitus. More specifically, a method is disclosed for predicting the risk of developing renal failure for a subject suffering from diabetes mellitus, the method including the steps of determining the... Agent: Roche Diagnostics Operations Inc.

20110033941 - Risk analysis in patients with and without metabolic syndrome: The present invention relates to a method for identifying a subject being susceptible to a metabolic syndrome related therapy based on determining the amounts of adiponectin, retinol binding protein 4, and proinsulin in a sample of a subject, and comparing the thus determined amounts to suitable reference amounts. Moreover, the... Agent: Roche Diagnostics Operations Inc.

20110033943 - Hydrogen sulphide sampling method: The invention relates to a method for sampling a sulphur-containing solid product including supplying a gas flow comprising hydrogen sulphide, bringing the gas flow into contact with a solid reagent and reacting the solid reagent with the hydrogen sulphide contained in the gas flow, the reaction fixing the sulphur of... Agent: Marsh, Fischmann & Breyfogle LLP

20110033944 - Method for measuring hypochlorite ion: e

20110033945 - Colorimetric assay for pyrethroid insecticides: The invention relates to an assay to test for pyrethroids in a sample. The assay is particularly useful for testing material treated with pyrethroids, such as bed netting and the like.... Agent: Klarquist Sparkman, LLP

20110033946 - Detection of short-chain fatty acids in biological samples: Described herein is a method of detecting and/or quantifying analytes, such as short-chain fatty acids. Analysis for the presence and/or quantity of the small molecule can be performed on a biological sample from a subject. In some embodiments, a liquid chromatography/mass spectrometry (LC-MS/MS) instrumentation is combined with a solid-phase extraction... Agent: Wilson, Sonsini, Goodrich & Rosati

20110033947 - Method of detecting target substance and target-substance detection kit: Provided is a detection method for a target substance capable of enhancing detection sensitivity and quantitative property of a magnetic biosensor, while keeping monodispersity and dispersion stability of magnetic markers, including the steps of: reacting the target substance in a sample solution with a first target substance trapping member immobilized... Agent: Fitzpatrick Cella Harper & Scinto

20110033948 - Method of reading encoded particles: Microparticles 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 having a plurality of colocated pitches Λ which represent a unique identification digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely... Agent: The Small Patent Law Group LLP

20110033949 - Teflon container for sample decomposition using gas condensation by air cooling: When an atomic absorption spectrophotometer (AAS) or inductively coupled plasma (ICP) is used, samples must be introduced in a liquid state. Thus, sample decomposition by acids must be performed. Methods for decomposing samples using beakers or microwaves have caused several problems such as loss of volatile elements, excessive use of... Agent: Christopher Paul Mitchell

20110033951 - Assay method and kit for nucleic acid binding protein: An object of the present invention is to provide a method of detecting a nucleic acid binding protein and a method of screening for a binding inhibitor or promoter for a nucleic acid binding protein. According to the present invention, there is provided a method of detecting binding between a... Agent: Clark & Elbing LLP

20110033950 - Turbidimetric immunoassay for assessing human cystatin c: There is a demand for improved turbidimetric immunoassays for human Cystatin C in biological samples, especially in human clinical samples of body fluids. The present invention provides a turbidimetric immunoassay method and reagent set enabling measurement of human Cystatin C by turbidimetric methods, resulting in a surprisingly stronger and faster... Agent: Edwards Angell Palmer & Dodge LLP

20110033953 - Characterization of reaction variables: A microscale method for the characterization of one or more reaction variables that influence the formation or dissociation of an affinity complex comprising a ligand and a binder, which have mutual affinity for each other. The method is characterized in comprising the steps of: (i) providing a microfluidic device comprising... Agent: Fulbright & Jaworski, LLP

20110033952 - Sensor for biomolecules: A sensor for biomolecules includes a silicon fin comprising undoped silicon; a source region adjacent to the silicon fin, the source region comprising heavily doped silicon; a drain region adjacent to the silicon fin, the drain region comprising heavily doped silicon of a doping type that is the same doping... Agent: Cantor Colburn LLP-ibm Yorktown

20110033954 - Biofunctionalized quantum dots for biological imaging: Novel biofunctionalized quantum dots include a mercaptoalkanoic acid linked to the surface of a nanocrystalline core and a biofunctional group linked to the surface. Biofunctionalized quantum dots are made by a novel synthesis method. Biofunctionalized quantum dots can be used in imaging or therapy applications.... Agent: Woodcock Washburn LLP Ott-nih

20110027892 - Methods and systems for identification, extraction, and transfer of analytical data for process control: Disclosed are methods, apparatuses, and systems, for (1) providing reliable identification of analytes from an HPLC or other analytical instrument, (2) ensuring data integrity during transfer of analytical data from the instrument to, for example, a control application or other destination, and (3) near-immediate transfer of the data after analysis.... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20110027893 - Method and apparatus for automated determining of chemical oxygen demand of a liquid sample: A method and apparatus for automated determining of the chemical oxygen demand of a liquid sample, comprising steps as follows: mixing the liquid sample with sulfuric acid; introducing a carrier gas, especially air, into the liquid sample-sulfuric acid mixture; adding an oxidizing agent to the liquid sample-sulfuric acid mixture to... Agent: Bacon & Thomas, PLLC

20110027894 - Biomarkers for detection of early- and late-stage endometrial cancer: Biomarker proteins that can be used in the diagnosis of early-stage endometrial cancer are described. Methods of screening for endometrial cancer, as well as methods of detecting and monitoring the status of endometrial cancer are provided. The biomarkers can be used to detect a variety of endometrial cancers, including endometroid... Agent: Karen S. Canady Canady & Lortz LLP

20110027895 - Determination method of magnesium content in aluminium alloy: The present invention discloses a method for determination of magnesium content in aluminum alloy, including: dissolving an aluminum alloy sample, using one or more compounds selected from the group consisting of mercapto-containing compound, acetone cyanohydrin, β-aminoethyl mercaptan, triethanolamine, tetraethylenepentamine, ethylene diamine and oxydol as masking agent, using eriochrome black T... Agent: Townsend And Townsend And Crew, LLP

20110027896 - Chromophore and polymer capable of detecting the presence of various neurotoxins and method of use: Applicants have produced a chromophore and a polymer that are highly sensitive to the presence of various agents, including organophosphates, pesticides, neurotoxins, metal ions, some explosives, and biological toxins. The detection is accomplished by detecting a change in the fluorescence characteristics of the chromophore or polymer when in the presence... Agent: Nyemaster, Goode, West, Hansell & O''brien, P.C.

20110027897 - Biomarker to measure drug efficacy in enteropathic disease: The response of a patient with an enteropathic disease to therapy, particularly a candidate therapy in a clinical trial setting, is assessed by detecting the ability of the patient to metabolize an orally administered CYP3A substrate. The CYP3A metabolism may be monitored in a variety of ways. Conveniently, the appearance... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20110027898 - Methods and articles for strand-specific polynucleotide detection with conjugated polymers: The invention further relates to conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in... Agent: Techlaw LLP

20110027899 - Hazardous chemicals detector & methods of use thereof: Embodiments of the invention are directed to an apparatus and method for detecting explosive compounds by air sampling followed by subjecting the air sample to a detection method. In one embodiment, a test area is sampled by drawing air from the vicinity of the test area, heating or irradiating the... Agent: Loza & Loza LLP

20110027900 - Thiol quantitation assays and related methods: The present invention is generally directed to thiol quantitation assays, methods of performing the assays, and compounds used in the assays. It is more specifically directed to assays that include one or more disulfides and related molecules and methods. The disulfides contain a FRET pair.... Agent: Jeffrey A. Mckinney, J.d., Ph.d.

20110027901 - Methods and devices for detecting the presence of an analyte in a sample: Sensor assay methods for detecting the presence of an analyte in a sample are provided. Aspects of the methods include providing a sensor, e.g., a proximity sensor, in contact with an assay composition that includes a sample and a proximity label. Next, a capture probe configured to bind to the... Agent: Stanford University Office Of Technology Licensing Bozicevic, Field & Francis LLP

20110027903 - Fecal sampling device and method: A specimen sampling device having a first panel including multiple apertures (e.g., a first, second and third aperture) for receiving samples; a second panel having a removable tab at least partially aligned with the first, second and third apertures for receiving the samples, the removable tab accessible from an exterior... Agent: Stroock & Stroock & Lavan LLP

20110027904 - Sample mixing on a microfluidic device: Mixing structures for use on sample processing devices are disclosed. The mixing structures include one or more mixing chambers in fluid communication with a process chamber, such that changing the rotational speed of the sample processing device forces sample material into and out of the mixing chamber to achieve mixing... Agent: 3m Innovative Properties Company

20110027902 - Structure for introducing a plurality of solutions, micro fluidic device having said structure and method for introducing solution: The present invention relates to a structure (a solution introducing structure) for introducing a plurality of solutions (a sample and/or a reagent solution) in highly accurate volume, in high amount and simply, into a channel, in particular a channel of a micro fluidic device, a micro fluidic device having said... Agent: Foley And Lardner LLP Suite 500

20110027905 - Systems and methods for collection and analysis of analytes: Systems and methods are provided for collecting and analyzing analytes. One embodiment of the invention includes a system for collecting analyte. The system comprises a sampling section disposed on a collection platform and an air source that provides an analyte to be sorbed by the sampling section. The sampling section... Agent: Tarolli, Sundheim, Covell & Tummino L.L.P.

20110027906 - Metering doses of sample liquids: A device and method of metering and mixing a dose of a sample liquid with a diluent liquid includes introducing a sample liquid into a channel defined in a housing. The housing defines a pocket open to the channel and sized to both collect a metered dose of the sample... Agent: Fish & Richardson P.C. (bo)

20110027909 - Chimera compositions and methods of use: This invention is directed to novel compositions, process methods, research tools, and use of these in the identification and development of novel therapeutic and/or diagnostic products. The compositions of the invention are chimera proteins that in essence recreate and/or potentiate one or more protein complex interactions that occur in vivo... Agent: Convergent Law Group LLP

20110027908 - Device for detection of antigens and uses thereof: Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.... Agent: Pepper Hamilton LLP

20110027912 - Purified serum albumin, and immunological measurement method: The present invention provides a purified serum albumin, which is a serum albumin used as a blocking agent and/or in a suspension containing an insoluble carrier in an immunoassay method, and is composed mostly of a fraction, the fraction having an absorbance of not exceeding 9.0 mAbs when measured in... Agent: Wenderoth, Lind & Ponack, L.L.P.

20110027910 - Screening: A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test... Agent: Wolf Greenfield & Sacks, P.C.

20110027911 - Solubilization and study of membrane proteins: Provided are methods for solubilizing a membrane protein in order to provide substantially homogeneous membrane proteins that are solubilized within reverse micelle systems at concentrations that are suitable for analytical study of such membrane proteins, including nuclear magnetic resonance spectroscopy. Also provided are substantially homogeneous membrane proteins that are solubilized... Agent: Woodcock Washburn LLP

20110027907 - Ssl7 mutants and uses therefor: The invention relates to SSL7 mutants which have no, or at least reduced, ability to bind to IgA. The mutants have significant application in the purification or isolation of C5 from samples and in the identification or detection, including quantitation, of C5 in samples. Use of the mutants has the... Agent: Occhiuti Rohlicek & Tsao, LLP

20110027913 - Multiplexed nanoscale electrochemical sensors for multi-analyte detection: Provided are nanoscale devices suitable for multiplexed, parallel detection of multiple analytes and methods for fabricating such devices.... Agent: Woodcock Washburn LLP

20110027914 - Sample plate systems and methods: A sample plate comprising a sample well is disclosed. The sample well can comprise one or more bead retaining chambers. Also provided herein is a method of using the sample plate and kits comprising the sample plate.... Agent: Wilson, Sonsini, Goodrich & Rosati

20110027915 - Method of producing insoluble carrier particles, insoluble carrier particles, measurement reagent, specimen analyzing tool, and immunoturbidimetric assay: The present invention provides a measurement reagent that is capable of suppressing nonspecific aggregation even when the amount of antibody to be carried is increased, and is capable of measuring in a wide measurement concentration range with high measurement sensitivity; an immunoturbidimetric assay using the same; and a method of... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20110027916 - Detection apparatus for detecting particles: The invention relates to a detection apparatus for detecting particles (25), wherein the detection apparatus comprises a detection surface (30) for detecting particles on the detection surface and wherein the detection surface (30) comprises protrusions (40) for limiting a movement of the particles (25). Preferentially, the protrusions (40) divide the... Agent: Philips Intellectual Property & Standards