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Chemistry: analytical and immunological testing August inventions list 08/10

20100216246 - Combination drive for a sampling system for collecting a liquid sample: A sampling system for collecting a liquid sample, having at least one analytic auxiliary means is proposed. The sampling system has a coupling element for coupling onto the analytic auxiliary means and at least one drive unit for driving a movement of the coupling element from a rest position into... Agent: Bose Mckinney & Evans LLP

20100216248 - Disposable chamber for analyzing biologic fluids: An apparatus for analyzing biologic fluid is provided that includes a first planar member, a second planar member, and at least three separators. At least one of planar members is transparent. The separators are disposed between the members, and separate the members to form a chamber having a height. At... Agent: O''shea Getz P.C.

20100216247 - Identification of biomarkers for screening and monitoring of prostate cancer and prostate related diseases: A system and method for determining presence of prostate cancer or prostate related diseases is provided. The method includes first obtaining a test sample from a test subject. Next, at least one ultrastructural biomarker indicative of prostate cancer within the sample may be identified. Thereafter, qualitative or quantitative data from... Agent: Greenberg Traurig, LLP

20100216249 - Dna-based biosensors: There is described a method of detection of the protein-dependent coincidence of DNA in a sample which comprises detection using luminescence of one or more luminophores introduced into DNA with one, two or more DNA fragments which fragments are bound using one or more DNA-binding proteins.... Agent: Speckman Law Group PLLC

20100216250 - Methods for predicting trisomy 21 in a fetus: The present invention relates to biomarkers in maternal serum samples and methods for predicting whether a fetus has Trisomy 21 during the first trimester of pregnancy based on the differential expression of a combination, or subcombination, of the same.... Agent: Thermo Finnigan LLC

20100216251 - Use of acetic nitric acid reagent for extraction of oligosaccharides and polysaccharides to characterize carbohydrate materials from plants and other sources of cellulose using glycan oligomer analysis: This patent application is for the use of acetic nitric reagent (80% acetic acid, 1.8 N nitric acid) for the extraction of oligosaccharides and polysaccharides from carbohydrate containing materials The material is extracted with the acetic nitric reagent in a boiling water bath for various periods of time, usually 30... Agent: Allen K. Murray, Ph.d. Glycozyme, Inc.

20100216252 - Lanthanide complexes, preparation and uses thereof: The complex consists of an Ln ion and a ligand R2—C(X—R1)(R3)—NR4R5. R1 is a functional group, X is a single bond or a hydrocarbon-based chain consisting of at least one alkylene or alkenylene group optionally comprising at least one hetero atom or an arylene. R2 is an anionic group A2... Agent: Merchant & Gould PC

20100216254 - Drug monitoring assay: A method for obtaining at least one binding agent which binds a pharmaceutically active form of the compound with a higher specificity than a pharmaceutically inactive form of the compound is described by using special derivatives of said parent compound. The invention also pertains to the respectively created binding agents... Agent: Novartis Corporate Intellectual Property

20100216255 - Methods of determining active levels of drugs in fluid samples: Methods for determining the presence and level of active drugs in fluid samples are provided. Advantageously, entire families or classes of drugs can be tested for in one test by identifying the enzyme or receptor upon which members of that drug family act and measuring enzyme activity levels or binding... Agent: Hovey Williams LLP

20100216253 - Organic material-immobiling structure and method for production of the same, and peptide and dna therefor: The invention provides an organic material-immobilizing structure employing new immobilization means, characterized in that at least a part of the surface of the substrate is comprised of one or more members containing silicon oxide, the organic material is bound to the surface of the substrate through a binding domain bound... Agent: Fitzpatrick Cella Harper & Scinto

20100216256 - Nanobelt-based sensors and detection methods: A biosensor is provided which includes a substrate, a source electrode on the substrate, a drain electrode on the substrate, and at least one functionalized nanobelt on a surface of the substrate between the source electrode and the drain electrode. Methods for sensing a biological or chemical analyte using the... Agent: Sutherland Asbill & Brennan LLP

20100216257 - Method of assaying antigen and reagent therefor: A latex agglutination method by which the measurement range is extended and the sensitivity of the measurement in the low concentration range is increased, is disclosed. The method for measuring a test antigen by latex agglutination uses two types of large and small particles, having different average particle sizes. Each... Agent: Birch Stewart Kolasch & Birch

20100210019 - Sample analyzer, sample analyzing method, and computer program product: The present invention is to present a sample analyzer comprising: a reagent container holder; a measurement unit; and an information processing unit configured to perform operations comprising: controlling the measurement unit so as to start the successive measurement of the plurality of samples; determining whether or not to switch from... Agent: Sughrue Mion, PLLC

20100210020 - Method for analyzing dithiocarbamate pesticide using microwave-assisted thermal digestion and extraction: A method for analyzing a dithiocarbamate pesticide, which can ensure analytical precision with both ease and promptness is provided. The method for analyzing a dithiocarbamate pesticide comprises adding a crude drug, a preparation containing the same, or a treated product thereof, an aqueous acid catalyst solution, L-cysteine or a salt... Agent: Lucas & Mercanti, LLP

20100210021 - Process and markers for the diagnosis of kidney diseases: A process for the diagnosis of kidney diseases comprising the step of determining the presence or absence or amplitude of at least three polypeptide markers in a urine sample, the polypeptide markers being selected from the markers characterized in Table 1 by values for the molecular masses and migration times.... Agent: Dardi & Herbert, PLLC

20100210022 - Systems for and methods of detecting mastitis: Method and systems for determining if one or more animals has mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Systems and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of... Agent: Licata & Tyrrell P.C.

20100210023 - Salivary metabolic biomarkers for human oral cancer detection: The present invention provides a novel oral cancer and periodontal disease salivary metabolome for use in the diagnosis or for providing a prognosis for oral cancer and periodontal disease in an individual. The present invention also provides novel methods of diagnosing or providing a prognosis for oral cancer or periodontal... Agent: Oliff & Berridge, PLC

20100210025 - Common module profiling of genes: A system for profiling a genomic sequence comprising assigning modules to a genome, wherein each module has a defined sequence characteristic and the genome is divided into modules; assigning a value or weight to a module for a given profile, wherein the presence of one or more modules in a... Agent: Morgan, Lewis & Bockius LLP (sf)

20100210024 - Methods for producing surface bound oligonucleotide on solid substrate and uses thereof: The present invention relates to methods for producing an oligonucleotide on a solid substrate surface and methods for using the same. Some aspects of the invention provide methods for selecting a single DNA molecule reproducibily with an atomic force microscope (AFM).... Agent: Don D. Cha

20100210026 - Alkalinity determination: Alkalinity determination, including an alkalinity determination process and/or alkalinity determinator. An alkalinity determination process may include providing a known value of volume of an acidic fluid, forming a titration system by providing one or more additions of a known value of volume of a relatively alkaline fluid to an acidic... Agent: George Mason University Office Of Technology Transfer, Msn 5g5

20100210028 - Measuring method using biosensor: In a biosensor for measuring the concentration of an object to be analyzed by optical signal detection, when a liquid sample is supplied to a supply part (12), the liquid sample is developed in a development part (13), and color development takes place in a reaction part (14) depending upon... Agent: Hamre, Schumann, Mueller & Larson P.C.

20100210027 - Method for determining effect of preformulation forms on their dissolution rates: Preformulation analysis and optimization comprising dissolution strudies.... Agent: Woodcock Washburn LLP

20100210029 - Device and methods of detection of airborne agents: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and... Agent: Joseph R. Baker, Apc Gavrilovich, Dodd & Lindsey LLP

20100210030 - Assembly of semiconductor nanoparticle phosphors, preparation method of the same and single-molecule observation method using the same: Disclosed are an assembly of semiconductor nanoparticle phosphors, which can provide stable evaluation without variation in emission wavelength or in intensity of emission among the particles when used as a labeling agent through which a single-molecule observation is carried out, a preparation method of the assembly, and a single-molecule observation... Agent: Lucas & Mercanti, LLP

20100210035 - Human proteins responsible for nedd8 activation and conjugation: The invention relates to covalent modification of proteins through their conjugation with other proteins. More particularly, the invention relates to the modulation of such conjugation involving the protein NEDD8. The invention provides compositions and methods for detecting and/or modulating the activation and/or conjugation of NEDD8, as well as compositions and... Agent: Millennium Pharmaceuticals, Inc.

20100210034 - Methods of determining patient response by measurement of her-3: The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3.... Agent: Kilpatrick Stockton LLP

20100210033 - Portable device for detecting food allergens: The invention relates to a portable device and method for detecting allergenic substances.... Agent: Edwards Angell Palmer & Dodge LLP

20100210036 - Ppar active compounds: Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.... Agent: Foley & Lardner LLP

20100210032 - Specificity and sensitivity enhancement in cantilever sensing: The invention is directed to a sensor system including at least one sensor and target specific receptors bound substrates for purposes of enhancing detection sensitivity. Optionally, the sensor system may include quantum dots for independently verifying the presence of a target molecule or compound. The sensor system may be particularly... Agent: Knoble, Yoshida & Dunleavy

20100210031 - Diagnostic test to exclude significant renal injury: Methods for determining the risk of developing acute renal failure in a human subject by measuring human neutrophil gelatinase-associated lipocalin (NGAL) are provided.... Agent: Licata & Tyrrell P.C.

20100210038 - Dry reagent particle assay and device having multiple test zones and method therefor: The present invention relates to a dry reagent assay device having at least one test zone and at least one reference zone, which provides an internal mechanism for assuring correct and reliable assay procedures and reagent qualities. In one embodiment, the present invention relates to an assay device having, at... Agent: Bayer Lerner, David, Littenberg, Krumholz & Mentlik, LLP

20100210037 - Microfluidic device: A method of controlling the flow of an aqueous fluid in a microfluidic device, which makes use of a fluid gate comprising a UCST (upper critical solubility temperature) polymer and which allows fluid to flow by raising the temperature of the fluid gate above the USCT. Also provided is a... Agent: Foley Hoag, LLP (w/isa) Patent Group

20100210039 - Sandwich immunoassay and monoclonal antibodies for comp, cartillage oligomeric matrix protein: The present invention provides a new sensitive direct sandwich assay for determining the presence of COMP in a clinical sample. Two monoclonal antibodies directed against separate antigenic determinants of the COMP molecules are used in the assay. The invention also relates to three particularly advantageous monoclonal antibodies per se that... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20100203642 - Generation of fluorescent microbead cellular surrogate standards: A method of producing microbead populations that mimics the fluorescence intensity profile distribution of fluorescent biological cells so that they may be used a standard for flow cytometry.... Agent: Roberto J. Rios

20100203643 - Sample rack system: A rack for an automated processing system. The rack includes a number of wells adapted to hold at least a first sample container having a first size, and a second sample container having a second size. The second size, which may be a diameter, a height, or both, is substantially... Agent: Hunton & Williams LLP Qiagen Gaithersburg Inc.

20100203644 - Diagnostic test for the detection of early stage liver cancer: The invention provides methods and kits to detect early stage hepatocellular carcinoma or a change in the gradation of hepatocellular carcinoma in mammals. The diagnostic marker is based on the profiling and identification of diagnostic carbohydrates present in a body fluid such as blood serum.... Agent: Traskbritt, P.C.

20100203647 - Chemical reporters of protein acylation: Methods and kits for detecting acylated proteins produced by cells that have been cultured or by cells within an organism are provided. Also provided are methods and kits for detecting acylated proteins produced by cells where affinity purification tags are that facilitate detection are used. Compounds useful for the detection... Agent: Thompson Coburn LLP

20100203645 - Novel zwitterionic dyes for labeling in proteomic and other biological anaylses: The invention relates to compositions and methods useful in the labeling and identification of proteins. The invention provides for highly soluble zwitterionic dye molecules where the dyes and associated side groups are non-titratable and maintain their net zwitterionic character over a broad pH range, for example, between pH 3 and... Agent: Cooley LLP Attn: Patent Group

20100203646 - Process for re-coating of a silica gel material: The present invention relates to a process for re-coating of a silica gel material with a coating, especially re-coating of an already used or spent coated silica gel material, and the re-coated silica gel material obtainable by the process, and uses thereof.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20100203648 - Microsensor material and methods for analyte detection: The compositions and methods relate to an organic polymer-inorganic particle sensor material for detecting analytes. Interactions between the polymer and the particles are affected by the presence of analyte, which displaces the polymer and increases its free volume. This change in free volume can be detected, e.g., using an embedded... Agent: King & Spalding LLP

20100203649 - Optochemical sensor element: An optochemical sensor element 9 measures gaseous or dissolved analytes, in particular of oxygen. The sensor element 9 includes a fluorophor 25 that is immobilized in a polymer matrix 23. The polymer matrix itself is formed of a polymer with a non-aromatic backbone. The sensor element 9 is useful in... Agent: Standley Law Group LLP

20100203650 - Biomolecule binding ligands: The invention provides biomolecule binding ligands, collections of biomolecule binding ligands, and their use in the purification of biological mixtures and in the identification of ligands having an affinity for a substance. The ligand is a compound of formula (III) or a compound of formula (IV): wherein for compounds of... Agent: Leydig Voit & Mayer, Ltd

20100203652 - Method and apparatus for selective capture of gas phase analytes using metal beta-diketonate polymers: A process and sensor device are disclosed that employ metal β-diketonate polymers to selectively capture gas-phase explosives and weaponized chemical agents in a sampling area or volume. The metal β-diketonate polymers can be applied to surfaces in various analytical formats for detection of: improvised explosive devices, unexploded ordinance, munitions hidden... Agent: Battelle Memorial Institute Attn:IPServices, K1-53

20100203651 - Methods and compounds for phototransfer: Methods are described for phototransferring a compound from a first surface to a second surface. Compounds are described with photocleavable linkers. Compounds attached to a first surface through a photocleavable linker are put in proximity (or contact) with a second surface, and then phototransferred to the second surface upon exposure... Agent: Peter G. Carroll Medlen & Carroll, LLP

20100203653 - Protein g-oligonucleotide conjugate: The present invention relates to a protein G conjugate, which is prepared by linking an N-terminal cysteine-tagged protein G variant with an oligonucleotide via a linker. The conjugate binds in a directional manner on the surface of a biochip and biosensor, thereby providing a biochip and biosensor having improved antibody... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20100197025 - Reader device and methods of use: This invention provides a reader device (10) for a test strip (14) (in particular an immunoassay test strip). The reader device has a channel (12) for receiving the test strip, and a movable sensor (26, 28, 30) located adjacent to said channel. The sensor comprises a source of radiation (26)... Agent: Pedersen & Company, PLLC

20100197026 - Solution for determining ovulatory period in women from a test tube of urine: The solution covered by the invention contains 0.5 to 9.0% by mass of hydrate salt of chloride anion Cl+ with a chemical element of bivalent kation of cobalt or copper, magnesium, manganese, zinc, calcium or a monovalent kation of sodium, potassium; 0.5 to 10.5% by volume of oxalic acid, formic... Agent: Pearl Cohen Zedek Latzer, LLP

20100197027 - An indicating fiber: A fiber, an articles formed from a fiber and methods of making the fiber and associate article are disclosed. In one embodiment, the fiber comprises a synthetic polymer and a color-changing indicator. The color-changing indicator is dispersed throughout the synthetic polymer. The color-changing indicator reacts in the presence of a... Agent: 3m Innovative Properties Company

20100197028 - Metabolic markers of diabetic conditions and methods of use thereof: Novel methods for assessing the state of a diabetic condition of a subject are described, comprising determining the amount of a metabolite in a sample from a body fluid or tissue of the subject. The methods may be used, for example, in diagnosing and monitoring insulin resistance, prediabetes, or the... Agent: Marshall, Gerstein & Borun LLP (tethys)

20100197029 - Direct method and reagent kits for fatty acid ester synthesis: Provided are efficient, cost-effective and water tolerant methods (e.g., single-vial methods) for preparing fatty acid esters from organic matter, comprising: obtaining organic matter comprising at least one fat substituent, contacting the organic matter in a reaction mixture with a basic solution under conditions suitable to provide for hydrolytic release of... Agent: Davis Wright Tremaine, LLP/seattle

20100197030 - Xanthene dyes comprising a sulfonamide group: The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research... Agent: Wilson, Sonsini, Goodrich & Rosati

20100197031 - Functionalized expanded porphyrins: Disclosed are functionalized expanded porphyrins that can be used as spectrometric sensors for high-valent actinide cations. The disclosed functionalized expanded porphyrins have the advantage over unfunctionalized systems in that they can be immobilized via covalent attachment to a solid support comprising an inorganic or organic polymer or other common substrates.... Agent: Fish & Richardson P.C.

20100197032 - Nanoassembled complexes of nucleic acids, avidin and polymers, use and preparation thereof: The present invention discloses new nanoassembled complexes consisting of a central nucleus formed by a high-affinity interaction from nucleic acids and avidin, wherein said nucleus is stabilized in aqueous solutions, even saline, and protected from further unspecific unwanted interactions by means of suitable polymeric agents capable to mask totally or... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20100197033 - Urine and serum biomarkers associated with diabetic nephropathy: Use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.... Agent: Occhiuti Rohlicek & Tsao, LLP

20100197034 - Sample holder for maldi mass spectrometric analysis, and mass spectrometric analysis method: Used is a sample holder for MALDI mass spectrometry, which has a CuO secondary particle as a laser-beam-absorbing matrix and in which the secondary particle comprises an aggregate of CuO primary particles having an average particle diameter of 100 nm or smaller and has an uneven surface arising from the... Agent: Clark & Brody

20100197035 - Sensor for measuring syngas ratio in the high temperature and pressure condition: An assembly and method for gas analysis. The assembly comprises a catalyst compartment for catalytically reacting a component of a gas sample, producing one or more gas species as products. A product compartment receives the gas species, and a sensing element within the compartment senses the amount of one or... Agent: Berliner & Associates

20100197036 - Portable measuring device: The invention relates to a portable measuring device for measuring the salinity, the acidity (pH) or other chemical and physical parameters on different types of surfaces (9) such as inner and outer surfaces of tubes and surfaces of floors, walls, ceilings and such like, whereby the measuring device comprises electronic... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100197037 - System for evaluating the ph and buffering capacity of moisture containing cleansing articles: A system comprising a moisture containing cleansing article and a visual pH indicator changing color at a pH above 4.0. The system can comprise a buffer, having preferably a pKa above 5.5. The system can comprise a set of instructions for evaluating moisture containing cleansing articles. The pH buffer of... Agent: The Procter & Gamble Company Global Legal Department - Ip

20100197038 - Microelectronic sensor device for optical examinations with total internal reflection: The invention relates to a microelectronic sensor device for optical examinations like the detection of target components that comprise label particles (1), for example magnetic particles (1). An input light beam (L1) is transmitted into a carrier (111) and totally internally reflected at a binding surface (112) to yield a... Agent: Philips Intellectual Property & Standards

20100197039 - Fluorescent materials for highly sensitive and selective sensing of amines and nanofibril materials made therefrom: where A and A′ are independently chosen from N—R1, N—R2, and O such that both A and A′ are not O, and R1 through R10 are amine binding moieties, solubility enhancing groups, or hydrogen such that at least one of R1 through R10 is an amine binding moiety. This perylene... Agent: Thorpe North & Western, LLP.

20100197040 - Assays for preimplantation factor and preimplantation factor peptides: The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently... Agent: Pepper Hamilton LLP

20100197041 - Nucleic acid binding assays: This invention relates to methods for screening compounds for the ability to interact with a nucleic acid target, assay kits useful thereof and compositions regarding same. In a particular aspect, the invention relates to specific binding assays employing fluorescent label(s). The methods involve assessing the conformation of nuclei acid targets... Agent: Foley & Lardner LLP

20100197042 - Reagent and method for immunological analysis: A reagent for immunological analysis, comprising a suspension of latex particles having an antigen or an antibody specific for a substance to be analyzed introduced into the surface of the latex particles, produced by polymerizing a monomer in the presence of the antigen or antibody to thereby synthesize the latex... Agent: Heslin Rothenberg Farley & Mesiti PC