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Chemistry: analytical and immunological testing January recently filed with US Patent Office 01/10

20100022007 - Microfluidic device for preparing mixtures: A microfluidic device for preparing a mixture, has a mixer. The mixer includes a plurality of chambers, each chamber having a volume of at most 1 microliter, a first plurality of channels, each channel fluidly connecting 2 chambers, a plurality of chamber valves, each chamber valve controlling fluid flow out... Agent: Ibm Corporation

20100022008 - Compositions and methods for detecting nerve agents: The present invention provides methods and compositions for detecting, identifying and measuring the abundance of chemical nerve agents. Methods and compositions of the present invention are capable of providing selective detection of phosphorous based nerve agents, such as nerve agents that are esters of methyl phosphonic acid derivatives incorporating a... Agent: Greenlee Winner And Sullivan P C

20100022010 - Chemical agent detection method and apparatus: A method and apparatus for detecting Chemical Warfare Agents (CWA) and Toxic Industrial Chemicals (TICs) that is simple, cost-effective, non-instrumental, and environmentally robust. Illustrative embodiments provide a material that responds by a color change and/or a change, in fluorescence when exposed to the toxic-chemical vapors.... Agent: Seyfarth Shaw LLP

20100022009 - Remote identification of explosives and other harmful materials: Embodiments of the present invention are generally directed to the remote detection of explosives and other harmful materials. In some such embodiments, such remote detection involves the use of semiconducting nanoparticles. In some or other such embodiments, such remote detection involves the use of photoacoustic detection and/or spectroscopy. In some... Agent: Fish & Richardson P.C.

20100022011 - Determination of explosives including rdx: The present invention provides sensors and methods for determination of an analyte. The analytes may be determined by monitoring, for example, a change in an optical signal of an emissive material upon exposure to an analyte. In some embodiments, the analyte and the emissive material may interact via a chemical... Agent: Wolf Greenfield & Sacks, P.C.

20100022012 - Nanosensors: Electrical devices comprised of nanowires are described, along with methods of their manufacture and use. The nanowires can be nanotubes and nanowires. The surface of the nanowires may be selectively functionalized. Nanodetector devices are described.... Agent: Harvard University & Medical School C/o Wolf, Greenfield & Sacks, P.C.

20100022013 - Direct mass spectrometric anlaysis of aggregates of therapeutic proteins: The invention relates to a method of using high-mass matrix assisted laser desorption-ionization (MALDI) mass spectrometry for the quantitative analysis of the amount of aggregation (dimers, trimers or multimers) of antibodies or other therapeutic proteins in purified pharmaceutical samples or complex biological matrices, as well as to the use of... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100022014 - Method for evaluating obesity controller: A method for efficiently evaluating or selecting an obesity controlling substance, a blood insulin regulating substance or a blood sugar regulating substance, is provided. A method for evaluating or screening an obesity controller, the method including administering a carbohydrate and a lipid to an animal, and evaluating or selecting a... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20100022015 - Analysis of mannosamine-containing capsular saccharides: Analysis of compositions that include saccharides having mannosamine residues, such as the capsular saccharide of N. meningitidis serogroup A, is facilitated by a method comprising the steps of: (i) hydrolysing polysaccharide in the sample, to give a hydrolysate; (ii) subjecting the hydrolysate to liquid chromatography; and (iii) detecting any mannosamine-6-phosphate... Agent: Novartis Vaccines And Diagnostics Inc.

20100022016 - Polyamide nucleic acid derivatives and agents, and processes for preparing them: The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or... Agent: Andrea Q. Ryan Sanofi-aventis U.s. LLC

20100022017 - Inorganic phosphate assays: Binding of inorganic phosphate to a phosphate binding protein can result in changes to the stacking of appropriately positioned chromophores, thereby resulting in a detectable change. The invention provides a phosphate-binding protein that undergoes a conformational change from an initial conformation to a final conformation upon binding of phosphate, wherein... Agent: Wenderoth, Lind & Ponack, L.L.P.

20100022018 - Rapid detection of sulfhydryl compounds using a papain based assay: The invention relates to a method for detecting compounds containing a free sulfhydryl group in a sample and a test device which is used to detect such compounds. The method and test device use a papain-based assay where the papain is initially complexed with a metal ion making it inactive.... Agent: E I Du Pont De Nemours And Company Legal Patent Records Center

20100022019 - Method of monitoring adsorbent bed breakthrough in a process for producing alkyl esters from vegetable or animal oil and from an aliphatic monoalcohol: A method of monitoring breakthrough of an adsorbent bed consisting for example of ion-exchange resins, used during a stage of purification of an ester stream containing glycerin, obtained for example in a vegetable or animal oil and aliphatic monoalcohol transesterification process, permits the instantaneous detection of the presence of glycerol... Agent: Millen, White, Zelano & Branigan, P.C.

20100022020 - Compositions for surface enhanced infrared absorption spectra and methods of using same: A composition comprising a substrate and at least one adsorbate associated with the substrate wherein the composition has an enhanced infrared absorption spectra. A method comprising tuning a nanoparticle to display a plasmon resonance in the infrared, associating an adsorbate with the nanoparticle to form an adsorbate associated nanoparticle, and... Agent: Conley Rose, P.C.

20100022022 - Fluorogenic homogeneous binding assay methods and compositions: Disclosed are binding substrate compositions, methods and kits useful for, among other things, detecting and/or characterizing binding interactions between molecules of interest.... Agent: Life Technologies Corporation C/o Intellevate

20100022021 - New azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions: Novel mono-azide substituted rylene-imide derivatives, their use in methods for the detection of analytes and reagents kits for the detection of analytes comprising said novel mono-azide substituted rylene-imide derivatives.... Agent: Connolly Bove Lodge & Hutz LLP 1007 North Orange Street

20100022023 - Pressure activatable chemiluminescent system useful for covert intrusion detection: This invention is directed towards chemiluminescent systems useful in the practice of methods of intrusion detection, compositions useful for intrusion detection and methods for their formation, and to covert intrusion detection techniques and compositions therefore containing an infrared light generating chemiluminescent system, blended into an earthen-like carrier that enable one... Agent: Mchale & Slavin, P.A.

20100022027 - Gene 763 of phytopathogenic fungus magnaporthe grisea and use thereof for identifying fungicidal compounds: The invention concerns a novel nucleic acid fragment of the genome of rice pathogenic fungus Magnaporthe grisea comprising a gene coding for a protein (hereafter referred to as gene 763) whereof the presence and integrity are indispensable for pathogenesis of said fungus with respect to rice and barley. The invention... Agent: Connolly Bove Lodge & Hutz, LLP

20100022029 - Homocysteine immunoassay: In immunoassays such as homocysteine immunoassays, it is known that the measured values can be dispersed due to the influence of inhibiting substances present in a biological sample on the immunoreaction. The present invention provides among other things a method whereby the influence of the immunoreaction inhibiting substances is easily... Agent: Paul D. Yasger Abbott Laboratories

20100022028 - Human ox2 receptors: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors or agonists thereof.... Agent: Immunex Corporation Law Department

20100022024 - Method for testing performance of reagents containing microparticles: The present invention provides: a method of testing the performance of reagents containing microparticles by mixing a standard specimen containing two or more kinds of ligands with two or more kinds of microparticles containing receptors capable of specifically binding to the respective ligands and being optically distinguishable, and detecting the... Agent: Kenyon & Kenyon LLP

20100022025 - Method of detecting human beta-defensins: A method of detecting β-defensin in a bodily sample from a subject includes reducing the electrostatic interaction between β-defensin and negatively charged moieties in the bodily sample prior to detecting the β-defensin with an antibody or epitope binding fragment thereof.... Agent: Tarolli, Sundheim, Covell & Tummino, LLP

20100022026 - Methods, kits, reagents and devices for detecting mesothelin and/or megakaryocyte potentiating factor in peritoneal fluids: Certain embodiments disclosed herein are directed to methods and kits for detecting and quantifying in patient peritoneal fluid, such as spent peritoneal dialysis buffer, peptides having amino acid sequences related to megakaryocyte potentiating factor. The methods and kits can be used to monitor the biological status of the mesothelial lining... Agent: Lando & Anastasi, LLP

20100015714 - Measurement of soil pollution: A soil sample of fixed volume is mixed with a drying agent (MgSO4) and then acetone. The liquid is filtered off and a sample is applied to the sensing surface of an attenuated total reflectance (ATR) device in an IR spectrometer. After evaporation of the acetone, absorption is measured in... Agent: Stites & Harbison PLLC

20100015715 - Microfluidic device including structure that includes air vent and valve, and method of transferring fluid using the same: A microfluidic device and a method of transferring a liquid material using the microfluidic device are provided. The microfluidic device includes a chamber storing a sealed liquid material, and a structure that flows air to the chamber, when the structure is rotated to generate centrifugal force, so that the liquid... Agent: Sughrue Mion, PLLC

20100015716 - Method for oil dilution ratio evaluation through radioactivity measurement: m

20100015717 - Mass tags for quantitive analysis: The present invention relates generally to novel protein modification reagents for fractionation and quantitative (differential) profiling of proteins in a complex mixture. The reagents react with amino acids or other protein components or structures and function as mass tags. The present invention provides methods of making the protein modification reagents... Agent: Sheridan Ross PC

20100015719 - Novel mixtures for assaying nucleic acid, novel method of assaying nucleic acid with the use of the same and nucleic acid probe to be used therefor: [Means for Solving Problems] 1) A mixture which comprises one internal standard nucleic acid and two nucleic acid probes labeled with a fluorescent dye; 2) a mixture for measuring Km value which comprises one internal standard nucleic acid having a partial mutation and one nucleic acid probe labeled with a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, L.L.P.

20100015718 - Substrate for analyzing coverage of self-assembled molecules and analyzing method using the same: Provided are a substrate for analyzing the coverage of self-assembled molecules and a method for analyzing the coverage of the self-assembled molecules in nanowire and nanochannel patterned on solid surface, solid surface, or bulk solid surface by using the nanoparticles. According to the method, the presence of specific functional groups... Agent: Lowe Hauptman Ham & Berner, LLP

20100015720 - Dynamic desalter simulator: A small-scale dynamic simulator for crude oil refinery desalters has a pressurized oil deviblis configured to hold a supply of crude oil and a water deviblis configured to hold a supply of wash water. At least one chemical feed pump selectively adds emulsion breaker chemicals to the desalter simulator and... Agent: Wegman, Hessler & Vanderburg

20100015721 - Detection of promiscuous small submicrometer aggregates: The invention provides methods for the detection of aggregating molecules that are capable of promiscuous or non-specific binding to proteins in a time efficient manner without the use of labels.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20100015722 - Detection apparatus: IMS apparatus has an inlet with a preconcentrator opening into a reaction region where analyte molecules are ionized and passed via a shutter to a drift region for collection and analysis. A pump and filter arrangement supplies a flushing flow of clean gas to the housing in opposition to ion... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator

20100015723 - Antagonists of interleukin-15: Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are incapable of transducing a signal through either the β- or γ-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against... Agent: Lahive & Cockfield, LLP Floor 30, Suite 3000

20100015725 - Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides: The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diagnostics and bioanalytical assay systems. The invention also provides methods of using... Agent: Morgan, Lewis & Bockius LLP (sf)

20100015724 - Lysine acetylation sites: The invention discloses 332 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100015727 - Method for determining transport activity of a transport protein: The present invention relates to a method for determining transport activity of a transport protein and its use for the identification of compounds which can modulate said transport activity.... Agent: Michael P. Morris Boehringer Ingelheim Usa Corporation

20100015726 - Single column immunological test elements: A plurality of individual single column test elements are provided for use in a clinical testing apparatus. Each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover strip used to access... Agent: Hiscock & Barclay, LLP

20100015728 - Assay device and method: A method for detecting an analyte can include binding an analyte with a first reagent which is associated with a magnetic particle, allowing analyte to interact with an excess amount of a second reagent capable of interacting with the analyte, and magnetically separating a portion of analyte-bound second reagent from... Agent: Steptoe & Johnson LLP

20100009452 - Functional peptide having activity of stimulating immune cell: A peptide having a sequence which satisfies all of the following requirements (I) to (V) and has an activity of stimulating an immune cell: (I) the number of constituent amino acid residues is 12 to 36; (II) the sequence is amphipathic; (III) the charge of the whole molecule is +2... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20100009453 - Method for determination of presence or absence of peptide compound pyy3-36: The present invention provides a method for determining in a pharmaceutical test formulation the presence or absence of a peptide compound PYY3-36 represented by the following amino acid sequence: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-X (SEQ ID NO: 1), wherein X is OH or a carboxy acid-protecting group, the method comprising (1) preparing a solution... Agent: Greenblum & Bernstein, P.L.C

20100009454 - Methods of using dyes in association with nucleic acid staining or detection and associated technology: Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with... Agent: Wilson, Sonsini, Goodrich & Rosati

20100009456 - Fast biosensor with reagent layer: A detection system (100) and a sensor chip (1) for detecting target molecules, and thus corresponding analytes in a sample is described. Typically the detection system (100) includes a sensor chip (1). The sensor chip (1) comprises on its detection surface (33) a dissolvable reagent layer (5). When the dissolvable... Agent: Philips Intellectual Property & Standards

20100009457 - Microfluidic device, sample analyzing method using the same, and dilution ratio measuring method: Provided are a microfluidic device, a method of analyzing a sample using the microfluidic device, and a method of measuring dilution ratios. The microfluidic device includes: a sample chamber which accommodates a sample to be tested; a dilution chamber which accommodates a diluent, receives the sample from the sample chamber,... Agent: Sughrue Mion, PLLC

20100009455 - Test sensor with under-fill protection: A test sensor for testing an analyte concentration in a fluid sample includes a pre-fill capillary, formed by a base and a lid of the test sensor, and a sensing capillary. The pre-fill capillary is in fluid communication with the sensing capillary. The pre-fill capillary is first filled with the... Agent: Nixon Peabody LLP

20100009458 - Detection method, detection apparatus, and sample cell and kit for detection: A sensor-chip includes a sensor-portion having at least a metal-layer deposited on a surface of a dielectric-plate. A fluorescent-label binding-substance in an amount corresponding to the amount of a detection-target-substance in a liquid-sample binds onto the sensor-portion. The amount of the detection-target-substance is detected based on the amount of light... Agent: Sughrue Mion, PLLC

20100009459 - Method and microfluidic device for combining reaction components contained in liquids: The invention relates to a method and a microfluidic device for combining reaction components contained in liquids. The method comprises the steps: application of at least one first liquid filament containing a first reaction component on a first carrier substrate; application of at least one second liquid filament containing a... Agent: Caesar, Rivise, Bernstein, Cohen & Pokotilow, Ltd.

20100009460 - Multifunctional vacuum manifold: A laboratory device design particularly for a multiplate format that includes a manifold wherein the position of the plate is not a function of gasket compression or vacuum rate applied. In one embodiment, the device has a modular design, wherein one or more removable inserts, preferably with different functionalities can... Agent: Millipore Corporation

20100009465 - Method for the analysis of circulating antibodies: l

20100009464 - Method for the quantitative evaluation of sex hormones in a serum sample: This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different sex hormones in a serum sample, which can be used to evaluate different clinical situations. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the... Agent: Weili Cheng

20100009461 - Npcil1 (npc3) and methods of identifying ligands thereof: The present invention provides human, rat and mouse NPCIL1 polypeptides and polynucleotides encoding the polypeptides. Methods for detecting ligands which bind to NPC1L1 and block intestinal cholesterol absorption are provided. Also included is a method of identifying ligands which bind to NPCILI using membranes derived from brush border membrane preparations.... Agent: Merck And Co., Inc

20100009463 - Reagents for the detection of protein phosphorylation in signaling pathways: The invention discloses novel phosphorylation sites identified in signal transduction proteins and pathways, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified... Agent: Nancy Chiu Wilker, Ph.d. Chief Intellectual Property Counsel

20100009462 - Timp-2 as target/marker of beta cell failure: The present invention relates to the monitoring of disease progression and diagnosis of beta-cell failure in diabetes by measuring levels of TIMP-2 in a liquid sample, and to screening for novel compounds for the prevention and/or treatment of diabetes.... Agent: Hoffmann-la Roche Inc. Patent Law Department

20100003760 - Analysis of beryllium in soils and other samples by fluorescence: An improved low-cost practical method of determining beryllium or a beryllium compound thereof in a sample is disclosed by measuring fluorescence. This method discloses methods to lower the back ground fluorescence. Further, the method is extended to improved analysis of beryllium in soils by including a heating step.... Agent: Lawrence R. Oremland, P.C.

20100003761 - Methods for the diagnosis of dementia and other neurological disorders: The present invention is directed to a method for differentially diagnosing dementia or the risk of dementia in a patient. The method comprises obtaining a sample from the patient; analyzing the sample to obtain quantifying data for one or more than one metabolite marker; comparing the quantifying data for the... Agent: Nixon Peabody LLP - Patent Group

20100003762 - Permanent chemical marker and identification of information in polymers: The invention relates to a process for chemical marking and identification of information in polymers and additives, such as ageing additives, thermal stabilizer additives, light stabilizer additives, plasticizer additives or flame retardant additives and dyes and other high-value additives. The marking is effected by the use of defined atomic masses... Agent: Propat, L.L.C.

20100003763 - Long wavelength thiol-reactive fluorophores: Reactive fluorescent dyes compositions and methods of using same are disclosed. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed having thiol-reactive groups. Squaraine nucleus, Nile Red nucleus, benzodioxazole nucleus, coumarin nucleus or aza coumarin nucleus dyes are disclosed that exhibit a fluorescence... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20100003764 - Optical sensor: An optical sensor for monitoring an environmental condition, the optical sensor comprising a perfluorosulfonate ionomer membrane comprising a solution, wherein the solution comprises a transition metal-free dye component, wherein exposure of the optical sensor to a specific environmental condition produces a color shift on the optical sensor.... Agent: Dinsmore & Shohl LLP

20100003765 - Methods and systems for mitigating oxygen enhanced damage in real-time analytical operations: Methods and systems for performing analytical reactions under reduced or non-oxygen conditions, where such reactions are potentially subject to damaging effects of oxygen, including particularly fluorescent based detection methods where fluorescent species may be prone to generation of reactive oxygen species.... Agent: Pacific Biosciences Of California, Inc.

20100003766 - Cysteine engineered antibodies and conjugates: t