Chemistry: analytical and immunological testing inventions 07/09

20090191637 - Method and apparatus for determining anticoagulant therapy factors: Methods and apparatus are disclosed for determining a new anticoagulant therapy factors for monitoring oral anticoagulant therapy to help prevent excessive bleeding or deleterious blood clots that might otherwise occur before, during or after surgery. New anticoagulant therapy factors maybe based upon the time to maximum acceleration from the time... Agent: Frank J. Bonini, Jr. Harding, Earley, Follmer & Frailey

20090191638 - Assay preparation plates, fluid assay preparation and analysis systems, and methods for preparing and analyzing assays: Assay preparation plates are provided which include an array of wells, a magnet, and an actuator configured to move the magnet proximate and remote relative to the array. A fluid assay preparation and analysis system is provided which includes a pipette disposed above an assay plate receiving area, a magnet... Agent: Daffer Mcdaniel LLP

20090191640 - Methods of screening for atherosclerosis: Methods for screening for altered focal proliferation states in non-pregnant patients, which include detecting levels of pregnancy-associated plasma protein-A (PAPP-A), are described. Methods for identifying agents that alter the protease activity of PAPP-A, and pharmaceutical compositions and medical devices that include such agents also are described.... Agent: Fish & Richardson P.C.

20090191639 - Non-invasive rapid diagnostic test for m.tuberculosis infection: This invention relates to a test for detecting a Mycobacterium tuberculosis (tuberculosis or TB) infection in a patient or subject, specifically a diagnostic test, including a breath test, whereby patients are provided a small dose of an isotopically labeled TB drug, Isoniazid (INH) orally or directly to the lungs of... Agent: Coleman Sudol Sapone, P.C.

20090191641 - Immunodiagnostic test cards having indicating indicia: An immunodiagnostic test card includes a plurality of transparent chambers wherein each chamber includes a quantity of testing material that combines with a patient sample, when mixed, to produce an agglutination reaction. A plurality of indicia are disposed to aid in the manufacture and determining the usability of the cards... Agent: Hiscock & Barclay, LLP

20090191642 - Compositions, systems, and methods for continuous glucose monitoring: A polymeric sensing fluid for detecting the presence of glucose and systems and methods of its use are generally disclosed. The polymeric sensing fluid includes a polymer in a solvent (e.g., an aqueous solvent). The polymer has a plurality of boronic acid moieties extending from its polymeric backbone. As such,... Agent: Dority & Manning, P.A.

20090191643 - Rotatable test element: A test element and method for detecting an analyte with the aid thereof is provided. The test element is essentially disk-shaped and flat, and can be rotated about a preferably central axis which is perpendicular to the plane of the disk-shaped test element. The test element has a sample application... Agent: Roche Diagnostics Operations Inc.

20090191647 - Antibody pair screening methods: The invention provides methods for identifying antibody preparations that can form a pair of antibodies that optimally detect a target antigen, for example, in a sandwich immunoassay. These methods provide high affinity and epitope-specific antibodies.... Agent: Dority & Manning, P.A.

20090191645 - Compounds and methods for modulating integrin activity: The present invention provides methods and compositions for modulating integrin activity. In particular, the present invention encompasses methods and compositions for altering the interaction between the α and β chain extracellular clasp regions.... Agent: Polsinelli Shughart PC

20090191644 - Imprinted polymer for binding of organic molecules or metal ions: The invention relates to an imprinted polymer imprinted with an organic molecule or a metal ion wherein the matrix of the polymer has been prepared from one or more monomers including bilirubin or an analogue thereof. The imprinted polymers may be prepared by polymerising one or more monomers including bilirubin... Agent: Jacobson Holman PLLC

20090191646 - Molybdenum complex & test kit to enhance accuracy of analysis of endogenous analytes in biological fluids: Methods for enhancement in accuracy of immunochemical analysis of heterogeneous biological fluids containing exogenous substances that can interfere in immunochemical analysis for endogenous analytes of interest. According to this method a heterogeneous biological fluid sample is pretreated with an interferant suppression effective amount of a molybdenum coordination complex, so as... Agent: Mcdonald Hopkins LLC

20090191648 - Method and device to detect the presence of analytes in a sample: Disclosed are methods and apparatus useful for determining the presence or absence of one or more analytes in a liquid sample, such as a biological or environmental sample. In some embodiments, the method can use an indirect competitive immunochromatographic test strip.... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20090191649 - Biosensor and method of assaying object: A biosensor capable of analyzing an object, such as antigen, antibody, DNA or RNA, through detection of magnetic field to thereby allow washout of unbound label molecules to be unnecessary, which biosensor is compact and available at low price, excelling in detection precision. Coils are arranged at an upper part... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090191650 - Antibody specific for mutant presenilin 1 and method of use thereof: The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcripts and products of these genes are useful in detecting and diagnosing... Agent: Ropes & Gray LLP

20090186416 - Diluent wells produced in card format for immunodiagnostic testing: An immunodiagnostic test card includes a flat planar member and at least one dilution chamber that is supported by the flat planar member. The at least one dilution chamber can be disposed adjacent chambers used for testing a patient sample that are provided on the immunodiagnostic test card or can... Agent: Hiscock & Barclay, LLP

20090186417 - Method for determining the oxygen requirement of an aqueous solution for a purification process: Method of determining the oxygen demand, TOD or COD, of an aqueous solution, in particular of waste water, for a clarification process, wherein a sample of the aqueous solution is decomposed by combustion, such that the combustion is carried out without the presence of a catalyst, at a temperature above... Agent: Central Coast Patent Agency, Inc

20090186418 - Test method and kit: A test method and kit are disclosed. The method is for use with an object, said method comprising the steps of: (a) treating a surface of the object to expose an undersurface area; (b) exposing the undersurface to a sulfide; and (c) visually monitoring the appearance of the sulfide to... Agent: David M. Lachance

20090186419 - Luminescent metal oxide films: The present invention relates to articles and methods involving luminescent films which may be useful in various applications. Luminescent films of the present invention may comprise a layer of metal oxide nanoparticles and, in some cases, may interact with an analyte to generate a detectable signal, whereby the presence and/or... Agent: Wolf Greenfield & Sacks, P.C.

20090186420 - Microelectronic sensor device with washing means: The invention relates to a microelectronic sensor device, particularly to a bio sensor with magnetic sensor units comprising excitation wires (11, 13) and a GMR sensor (12). The device further comprises a washing unit (20) consisting of a series of actuation wires (21) coupled to a driving unit (22). The... Agent: Philips Intellectual Property & Standards

20090186421 - Catalytic biosensor: The present invention describes a biosening device and method. Specifically, binding of target analyte perturbs the surface of a sensor strip so that gas bubbles are generated in solution. The gas bubbles may be detected for determination of analyte presence in a sample.... Agent: Alan Joseph Bauer

20090186422 - Specific inhibitors of nfat activation by calcineurin and their use in treating immune-related diseases: Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein-protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions... Agent: Fish & Richardson PC

20090186423 - Method for characterization of a recombinant polyclonal protein: The present invention provides a characterization platform that can be used to assess the amount of different antibodies produced by a polyclonal cell line during production, as well as batch-to-batch consistency of the antibodies present in the polyclonal products. The structural characterization platform is based on removal of the heavy... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090181461 - Tumor marker for pancreatic cancer and method of testing the same: The determination (test, diagnosis) of pancreatic cancer can be performed with high accuracy by detecting a fucosylated sugar chain (N-glycan) present in a specific site of the human haptoglobin and using an amount of the fucosylated sugar chain as a tumor marker for pancreatic cancer.... Agent: Edwards Angell Palmer & Dodge LLP

20090181462 - Thioacids and thioacid salts for determining the enantiomeric excess of chiral compounds containing an electrophilic carbon center: The invention provides novel chiral compounds including 2-methoxy-2-trifluoromethylphenylacetic thioacid useful to react with and analyze other chiral compounds that have an electrophilic chiral carbon center.... Agent: Hugh Mctavish Mctavish Patent Firm

20090181464 - Accurate magnetic biosensor: A method is provided for determining the concentration of target in a fluid sample using a magnetic label and a magnetic sensor for detection. It was surprisingly found that efficient and accurate measurements can be carried out by determination of a signal as soon as the signal has reached a... Agent: Philips Intellectual Property & Standards

20090181463 - Device and method for chemical, biochemical, biological and physical analysis, re-action, assay and more: The invention is directed to a device and a method for carrying out experiments of chemical, biochemical, biological and physical analysis, reaction and assay employing a reaction unit, in a preferred embodiment comprising: a capillarity reaction chamber, non-capillarity zone and bottom structure, which can use capillary action to quantitatively take... Agent: Joyce Von Natzmer Pequignot + Myers LLC

20090181465 - Method for measuring volatile organic compounds and a kit for same: A method for measuring volatile organic compounds (VOCs) of a material produced in a process system is disclosed. The method involves an enclosed bag into which a sample of material is placed, after which the bag is stored at a predetermined temperature such that the contents reach equilibrium. The storage... Agent: Lathrop & Gage LLP

20090181466 - Indicator granular material: The present invention relates to indicator granular material, especially for a cat lavatory, in which at least one first granular material is substantially completely coated with a first polymer layer, which is solid at a first pH and is dissolved at a second pH; and also to a cat lavatory... Agent: Fulbright & Jaworski, LLP

20090181467 - Method of assessing and of activating the alternative cellular energy (ace) pathway in the therapy of diseases: Alternative cellular energy pigments (ACE-pigments) provide a source of cellular energy other than that provided through the oxidative metabolism of foods, or in the case of plants and certain bacteria, through the process of photosynthesis. In some patients, ACE pigments exist in a form that can be further energized or... Agent: William John Martin

20090181469 - Method of enhancing signal detection of cell-wall components of cells: The invention relates to methods of enhancing signal detection of components of cell walls, wherein the methods involve lysing cells to form cell-wall fragments and analyzing the cell-wall fragments.... Agent: 3m Innovative Properties Company

20090181468 - Methods and compositions for treating cellular proliferative diseases: The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, screening assays for identifying such compounds, and methods for treating such disorders.... Agent: Clark & Elbing LLP

20090181471 - Assay device and process for the testing of fluid samples: An assay device for testing of liquid samples for drugs of abuse has a transparent container for retaining a liquid sample. A backing member is within the container and is curved so that its front surface corresponds to the curvature of the container wall. Immunoassay test strips are on the... Agent: Stites & Harbison PLLC

20090181470 - Measurement kit and an immunochromatography method: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying... Agent: Birch Stewart Kolasch & Birch

20090181472 - Labeled molecule for prognosing tumor grade of head neck cancer and method for the same: The present invention discloses a labeled molecule for prognosing the tumor grade of head neck cancer and a method for the same, wherein a 78-kDA glucose regulated protein (GRP78) is adopted as a labeled molecule of head neck cancer. GRP78 is much more overexpressed in head neck cancer cells than... Agent: Sinorica, LLC

20090176308 - Apparatus and method for the purification of biomolecules: The invention comprises an apparatus 10 and a method 100 for automatically lysing, extracting and purifying biomolecules 28. As the central technology for purifying the biomolecules magnetizable particles 35 and an adapted magnet device 40 are used for binding and transferring the particles 35. The apparatus 10 comprises a highly... Agent: Intellectual Property / Technology Law

20090176309 - Fluorescent assay: A method and apparatus to estimate the concentration of a non-fluorescent substance (e.g. haemoglobin) in a fluorescent assay by separately estimating the non time dependent alteration attributed to inherent filter effects from the time dependent alteration caused by the assay chemistry. Such a method obviates the requirement for a separate... Agent: Fox Rothschild LLP

20090176310 - Detection procedures for fibrinogen and/or fibrinogen derivatives: Described are determination procedures for fibrinogen and/or fibrinogen-derivatives by matrix-independent turbidimetry. In the FIFTA called procedure the fibrinogen activity is preferably determined in an undiluted sample by addition of thrombin and/or albumin, as well as polybrene if appropriate, in PBS and determination of the increase in absorbance at 405 nm.... Agent: Connolly Bove Lodge & Hutz, LLP

20090176311 - Separation of conjugated and unconjugated components: The invention is based on the use of a basic reagent under basic conditions to separate conjugated saccharide from unconjugated components in a sample, e.g. a vaccine, by precipitation of the conjugated saccharide. The invention allows rapid and quantitative separation of conjugated and conjugated components, which may be exploited in... Agent: Novartis Vaccines And Diagnostics Inc.

20090176312 - Biological and chemical test media and system: An apparatus and method for performing medical, biological or chemical tests in the field is Disclosed. In some embodiments, the test media comprises a special purpose optical disc which is read, after application of the test specimen and subsequent processing using commonly available CD, DVD, High Definition DVD or Blu-Ray... Agent: Kelley Drye & Warren LLP

20090176313 - Fluorescent compound and labeling agent comprising the same: A novel fluorescent compound having a high light fastness, high fluorescence quantum yield and sharp absorption spectrum, which emits fluorescence having a wavelength in long wavelength region, as well as its use as a labeling agent, is disclosed. In Formula [I] below, by forming a specific hetero ring(s) with R1... Agent: Birch Stewart Kolasch & Birch

20090176314 - Reagent cartridge: A reagent cartridge which can be exchangeably inserted into an analyzer and having a plurality of reagent bags furnished with connecting lines, each of which may optionally be connected to an input device of the analyzer, and method for operating the analyzer are disclosed. Each reagent bag has an analyzer-controlled... Agent: Dinsmore & Shohl, LLP One Dayton Centre

20090176315 - Microfluidic pl-based molecular sorting: This invention is directed to methods and devices for separating molecules in a sample, based on differences in their isoelectric point (pI). The methods and devices make use of a diffusion potential created in a microfluidic chamber when a buffered solution comprising molecules, which differ in terms of their isoelectric... Agent: Pearl Cohen Zedek Latzer, LLP

20090176316 - Automated fluid handling cartridge, fluid processing system, and methods: The present invention relates to a cartridge, system, and methods that can be used for automated handling of fluids, such as blood. The cartridge can be configured to obtain a fluid sample from a sealed container, e.g., a septum sealed container. The system can be configured to handle the cartridge... Agent: Merchant & Gould PC

20090176318 - Binary dna probe for fluorescent analysis of nucleic acids: The invention is directed to binary oligonucleotide probes for nucleic analysis, which probes can be made of DNA or RNA that recognize nucleic acid analytes (both DNA and RNA) with unprecedented high selectivity under mild conditions and are highly sensitive to single nucleotide mismatches (SNP single nucleotide polymorphisms) without PCR... Agent: Ditthavong Mori & Steiner, P.C.

20090176317 - Soluble b7-h1: This document features methods of evaluating mammals by assessing expression of B7-H4 in the vasculature.... Agent: Fish & Richardson P.C.

20090176319 - Calibrator for immunoassays: The invention generally relates to the field of immunoassays. In particular, the invention relates to use of a calibrator material to calibrate immunoassays for autoantibodies.... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20090170207 - Reference ph sensor, preparation and application thereof: A reference pH sensor, the preparation and application thereof. The reference pH sensor is an extended gate field effect transistor (EGFET) structure and comprises a metal oxide semiconductor field effect transistor (MOSFET) on a semiconductor substrate, a sensing unit comprising a substrate, a solid-state conductive sensing layer on the substrate,... Agent: Quintero Law Office, PC

20090170208 - Biomarkers for ovarian cancer: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status in a patient. In particular, it has been found that the biomarkers set forth in Table 1 are biomarkers for ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.... Agent: Edwards Angell Palmer & Dodge LLP

20090170209 - Hydrogel chemical sensor: An apparatus and method for detecting an analyte wherein a member may respond to mechanical stress induced by a volume change of a sensitive hydrogel upon sensing an analyte and wherein the mechanical stress may be detected by a detector.... Agent: Cool Patent, P.C. C/o Cpa Global

20090170210 - Measuring device, measuring apparatus and method of measuring: The measuring device of the invention includes: a first container and a second container for holding a sample; and an optical measurement part for carrying out an optical measurement. The first container has a first sample supply inlet for supplying a sample containing an analyte to the first container and... Agent: Mcdermott Will & Emery LLP

20090170212 - Rapid magnetic biosensor: The present invention relates to methods and (bio)sensor systems. Herein, magnetic fields are applied in order to transport magnetic particles laterally over a sensor surface with analyte specific probes. The methods of the invention allow the specific binding of magnetic particles to the sensor surface, while aspecific and unbound particles... Agent: Philips Intellectual Property & Standards

20090170211 - Sensing switch and detecting method using the same: Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region... Agent: Cantor Colburn, LLP

20090170213 - High-throughput screening of enantiomeric excess (ee): The present invention provides a method for high-throughput screening of enantiomeric excess (ee), comprising synthesizing a sensor made from an aggregate of gold nanoparticles whose surfaces have been elaborated with a chiral “host” that includes two optically pure binaphthol groups linked together by a diethanolamine bridge that is tethered via... Agent: Ralph A. Dowell Of Dowell & Dowell P.C.

20090170214 - Luminescent reporter modality for analyzing an assay: An optical analysis flow system and a method of assay analysis includes a means for facilitating activation of a luminescent material coupled to particles entrained within a fluid assay, wherein the means is arranged such that the activation of the luminescent material is conducted at a site along a flow... Agent: Daffer Mcdaniel LLP

20090170216 - Selection of colorectal cancer patients for treatment with drugs targeting egfr pathway: Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a colorectal cancer (CRC) patient is likely to benefit from a drug targeting an epidermal growth factor receptor pathway, such as monoclonal antibody EGFR inhibitors.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090170215 - Selection of non-small-cell lung cancer patients for treatment with monoclonal antibody drugs targeting egfr pathway: Methods using mass spectral data analysis and a classification algorithm provide an ability to determine whether a non-small-cell lung cancer (NSCLC) patient is likely to benefit from a monoclonal antibody drug targeting an epidermal growth factor receptor pathway. A mass spectrum is obtained from a sample (e.g. blood sample) from... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20090170217 - Device for sample pretreatment, reactor sheet, and method of sample analysis: An object of the present invention is to introduce a sample solution into the minute and hydrophobic inside of a reactor for a pretreatment while avoiding bubble formation. According to the present invention, a reactor that has at least one portion having a width of 90% or less of its... Agent: Antonelli, Terry, Stout & Kraus, LLP

20090170218 - Methods for detection of cyclosporin a: Methods and reagents are disclosed for determining the presence and/or amount of cyclosporin A in a medium suspected of containing cyclosporin A. In the method a combination is provided in a medium. The combination comprises (i) the sample, (ii) a first member of a signal producing system (sps) associated with... Agent: Dade Behring Inc. Law And Patents

20090170219 - Nucleic acid capable of binding to immunoglobulin g and use thereof: The present invention provides a novel aptamer for IgG and a method for utilizing the same and the like. More specifically, the present invention provides an aptamer that binds to an Fc region of IgG (e.g., human IgG); a complex comprising an aptamer and a functional substance bound thereto (e.g.,... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090170220 - Bispecific capturing molecule: A capturing molecule having an association containing a plurality of polypeptide chains that specifically bind to different sites of a target substance, characterized in that each of the polypeptide chains has a domain having a hypervariable loop structure at a binding site binding to the target substance and an association... Agent: Fitzpatrick Cella Harper & Scinto