Chemistry: analytical and immunological testing inventions 04/09

20090111189 - Organic and inorganic mercury detection: An apparatus and method for the detection and quantitation of metals and metalloids in a sample by derivatization are provided. In particular, the apparatus and method relates to analysis of mercury in a sample by derivatization of the inorganic and organic mercury species into elemental mercury and organo-mercury hydrides using... Agent: Edward Yoo C/o Bennett Jones

20090111191 - Gas analyzer cassette system: A highly sensitive fluid composition analyzer where a fluid may be placed in contact with a very small area on a material sensitized to change color in the presence of a specific type of compound, to be impinged with light. The light reflected, transmitted and/or scattered by the material may... Agent: Honeywell International Inc.

20090111190 - Meander: A centrifugal based microfluidic device that comprises a microchannel structure in which there is a detection microcavity which in the upstream direction is attached to an inlet microconduit for transport of liquid (transport microconduit) to the detection microcavity and which is used for detecting the result of a reaction taking... Agent: Fulbright & Jaworski, LLP

20090111192 - Biogenic substance detector and biogenic substance detection method: The biogenic substance detector includes: a plurality of chambers 1011 for hybridizing a target and a probe; and a passage 1012 provided between the chambers 1011. The cross-sectional area of the passage 1012 taken perpendicularly to the chamber-passage alignment direction is smaller than the cross-sectional area of each chamber 1011... Agent: Harness, Dickey & Pierce, P.L.C

20090111193 - Sample preparation device: A sample preparation device is disclosed. The sample preparation device includes a housing defining a passage way between a first opening and a second opening; and a sample filter occupying a section of said passage way. The sample filter contains a monolith adsorbent that specifically binds to nucleic acids. Also... Agent: Andrews Kurth LLP Intellectual Property Department

20090111195 - Chemical reagents and methods for detection and quantification of proteins in complex mixtures: The invention provides a reagent comprising an affinity tag, a detectable moiety, a linker, an isotope tag and a reactive group. The invention also provides methods of using a reagent of the invention. The methods can be used to label a polypeptide in a sample by contacting a sample with... Agent: Mcdermott, Will & Emery

20090111194 - Methods and device for the detection of occult blood: The present invention relates generally to detection of occult blood. In particular, the present invention provides a device and methods for the simultaneous detection of hemoglobin and transferrin in fecal samples, which permit a more sensitive diagnosis of occult blood in fecal sample and a differential diagnosis of bleeding of... Agent: Scully Scott Murphy & Presser

20090111196 - Immunochromatography method: A object of the present invention is to provide an immunochromatography method that makes it possible to rapidly detect an ultratrace amount of an analyte that has been impossible to analyze by conventional immunochromatography methods. The present invention provides an immunochromatography method, which comprises developing an analyte and a labeling... Agent: Birch Stewart Kolasch & Birch

20090111197 - Hybrid device: A hybrid device (10) that combines a microfluidic component and a porous components (15) is provided. The microfluidic component includes a sample addition zone (1), a resuspension chamber (13), a mixing chamber (17), and a transfer structure (16), which facilitates fluid flow by capillary action.... Agent: Steptoe & Johnson LLP

20090104704 - Apparatus and method for anaylizing samples: A sample analyzer comprises a reaction tray, a sample/reagent tray, and a probe. The reaction tray performs a first number of stops and rotations during an operating cycle, wherein the first number is configured to cause each of the reaction vessels to stop once at a position for the test... Agent: Mindray C/o VistaIPLaw Group LLP

20090104705 - Ascorbic acid conjugates: Oxidative stress, resulting from the generation of reactive oxygen species, contributes to the development of a multitude of age-related diseases. Current methods of assessing oxidative stress levels range from the detection of lipid peroxidation products, such as F2-isoprostanes and malondialdehyde, to monitoring the redox status of glutathione. While useful, traditional... Agent: Klarquist Sparkman, LLP

20090104707 - Analyte detection with magnetic sensors: Methods for analyte detection with magnetic sensors are provided. Aspects of the methods include producing a magnetic sensor device having a magnetically labeled analyte from a sample, such as a serum sample, bound to a surface of a magnetic sensor thereof; and obtaining a signal, e.g., a real-time signal, from... Agent: Bozicevic, Field & Francis LLP

20090104706 - Cytokine receptor modulators, method of identifying same, and method of modulating cytokine receptors activity with same: The present invention relates to a method for identifying a non-competitive peptide, which inhibits the activity of a cytokine receptor. This method includes the steps of selecting a candidate peptide containing from about 7 to about 20 amino acids derived from a flexible region of a cytokine receptor, and determining... Agent: Choate, Hall & Stewart LLP

20090104708 - Human laminin receptor crystal and uses thereof: A human laminin receptor crystal is disclosed. Methods are disclosed for using various computer and non-computer means in order to develop models for use in the development of novel therapeutics that block and/or mimic laminin receptor interactions in the setting of, among others, Alzheimer's disease, other neurological disorders, cancer, and... Agent: Greenberg Traurig, LLP

20090104709 - Fluid transfer devices: A fluid transfer device includes a body and a sample holding reservoir formed in the body. The sample holding reservoir is capable of imbibing a fixed and very small quantity of fluid from a fluid source and dispensing the fixed quantity of fluid therefrom at a destination. The fluid transfer... Agent: Duane Morris LLP - Princeton

20090104710 - Colorimetric absorbance measurement method, apparatus and system: Various embodiments disclose a colorimetric absorbance measurement method and a system for performing the same. The method comprises driving a reaction tray carrying a plurality of reaction cuvettes to rotate at a speed; transferring or rotating filters on a filter wheel to a light path of a light beam, starting... Agent: Mindray C/o VistaIPLaw Group LLP

20090104711 - Fluorescent marker comprising double bond ester group and method for marking and detecting the same: Disclosed herein are fluorescent markers having a double bond ester group and a method for marking and detecting the same. More particularly, disclosed are a method for identifying oil products, which comprises marking the oil products with fluorescent markers having an unsaturated double bond ester group, adding a developing agent... Agent: Ipla P.A.

20090104712 - Hepatitis b pre-s2 nucleic acid: This invention relates to a nucleic acid molecule encoding a middle Hepatitis B virus (HBV) surface protein, a vector comprising the nucleic acid molecule, a host cell comprising the vector, and a composition comprising the expression products of this vector, which may comprise middle HBV surface protein, or a mixture... Agent: Paul D. Yasger Abbott Laboratories

20090104713 - Phenobarbital derivatives useful in immunoassay: Phenobarbital derivatives synthesized out of the alkyl chain at the 5-position, particularly with hydrophilic properties, and carrying an active ester at the end, allow formation of aminodextran conjugates that give curves in the desired range of the assay in the ONLINE TDM microparticle assay format when matched against the Roche... Agent: Roche Diagnostics Operations Inc.

20090104714 - Visual glucose sensor and methods of use thereof: A method for determining the presence or amount of one or more ligands or analytes in a sample including contacting the sample with a biosensor having an environmentally-sensitive dye conjugated to a binding member, wherein the biosensor compound exhibits a detectable color change as a result of binding to the... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20090104715 - Method for mixing two or more types of liquids in porous carrier: It is an object of the present invention to provide a method for simply mixing two or more types of liquids in a porous carrier. The present invention provides a method for mixing two or more types of liquids in a porous carrier, which comprises: laminating a first porous carrier... Agent: Birch Stewart Kolasch & Birch

20090104716 - Target substance detecting element, target substance detecting apparatus, and target substance detecting method: The present invention enables to classify and measure two or more kinds of target substances which have the same recognition site recognized by a specific capturing body. Specifically, by using a target substance detecting element for detecting two or more targets, whose kinds are different mutually, at the same time,... Agent: Fitzpatrick Cella Harper & Scinto

20090104717 - System to reduce incubation time in immunological testing using enhanced microwaves: A system for shortening incubation times on immunoassays employs energy that is applied to the assays. Energy is applied in careful gradations so that chemical bonds are not broken. If polyclonal antibodies, as opposed to monoclonal antibodies, are worked with, then because the bonds are stronger, cooling is employed in... Agent: Greenberg & Lieberman, LLC

20090098655 - Detection apparatus and methods: A chemical cell (40) containing silver nitrate is connected at the inlet (10) of an ion mobility spectrometer (1) so that sample gas for detection flows to the IMS via the chemical cell. When the sample gas contains arsine or phosphine, to which the IMS is not normally sensitive, this... Agent: Foley And Lardner LLP Suite 500

20090098656 - Mercury ionic gas standard generator for a continuous emissions monitoring system: A mercury ionic gas standard generator for use in the continuous emissions monitoring of exhaust flue gas streams is disclosed. More specifically, the mercury ionic gas standard generator uses a reservoir being coated with an inert silicon-based coating for transporting a volume of an aqueous ionic mercury solution to a... Agent: John S. Beulick (17851) Armstrong Teasdale LLP

20090098657 - Method and assembly for determining the temperature of a test sensor: An assembly determines an analyte concentration in a sample of body fluid. The assembly includes a test sensor having a fluid-receiving area for receiving a sample of body fluid, where the fluid-receiving area contains a reagent that produces a measurable reaction with an analyte in the sample. The assembly also... Agent: Nixon Peabody LLP

20090098658 - Microchip and method of using the same: A microchip includes fluid circuits therein, formed by uniting together at least a first substrate that is a transparent substrate and a second substrate having grooves provided at the substrate surface and/or through holes penetrating in a thickness direction. The fluid circuits include a liquid reagent receptacle unit to store... Agent: Fish & Richardson P.C.

20090098659 - Method of patterning particles on an arbitrary substrate and conducting a microfluidic invasion assay: A method is provided for sequentially patterning different particle populations on spatially defined regions in microfluidic device. The microfluidic device has a channel and a plurality of access ports therein. Each access port has an input and an output communicating with the channel. The method includes the step of depositing... Agent: Boyle Fredrickson S.c.

20090098661 - Method for determination of sample using agglutination reaction of immunological microparticle, and kit for the determination: A method for determining an analyte in a sample, includes the steps of: (a) mixing the analyte and a first specific binding substance, the first specific binding substance being a substance that can specifically bind to the analyte; (b) adding microparticles having a second specific binding substance bound thereto to... Agent: The Webb Law Firm, P.C.

20090098660 - Method for the purification of antibodies: A method for the purification of immunoglobulins by ion exchange chromatography is described. The chromatographic method uses a weak ion exchange resin and a single step elution process for the purification of an immunoglobulin. Additionally a method for the determination of the salt concentration for the single step elution of... Agent: Hoffmann-la Roche Inc. Patent Law Department

20090098662 - Determining the presence or amount of a metal-labelled species: A method for determining the presence or amount of a metal-labelled species in a sample may include causing the metal of the metal-labelled species in the sample to form a soluble electrochemically-active complex which is stable relative to moieties present or potentially present in the sample which will form an... Agent: Foley Hoag, LLP Patent Group (w/isa)

20090098663 - Novel water-soluble nanocrystals comprising a polymeric coating reagent, and methods of preparing the same: Disclosed is a water soluble nanocrystal comprising a nanocrystal core comprising at least one metal M1 selected from an element of main group II, subgroup VIIA, subgroup VIIIA, subgroup IB, subgroup IIB, main group III or main group IV of the periodic system of the elements (PSE), at least one... Agent: Seed Intellectual Property Law Group PLLC

20090093060 - Luminescent protein staining: The present invention relates to the use of cyclometalated iridium complexes for detecting poly(amino acids) including peptides, polypeptides, and proteins. Poly(amino acids) are detected in solution, in electrophorectic gels, and on solid supports, including blots. The method of the present invention is rapid, highly sensitive, and extremely facile.... Agent: Kwok-yi Wong

20090093061 - Protein separation device: The invention provides a protein separation device comprising a chaperone protein immobilised on a substrate. In one embodiment, the chaperone protein is an Hsp60 chaperone, preferably a group one chaperone, preferably GroEL. The invention also provides a method for isolating a protein from a biological sample using a protein separation... Agent: Oppenheimer Wolff & Donnelly LLP

20090093062 - Fluorescent dye compounds, conjugates and uses thereof: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090093063 - Color changing and coverage indicating hand sanitizer: The present invention includes compositions and methods for detection of the effectiveness of a substance for cleaning that include an electrophilic dye, wherein the electrophilic dye is colorless before exposure to a nucleophilic agent, and an nucleophilic agent, wherein the electrophilic dye, the nucleophilic agent or both are encapsulated and... Agent: Chalker Flores, LLP

20090093064 - Method of determining the presence of a mineral within a material: An improved flow-through device is provided wherein foam produced by the pumping of fluid in the device is kept outside the reaction chambers by way of a hydrophobic or hydrophilic porous membrane acting as an air trap membrane.... Agent: Philips Intellectual Property & Standards

20090093065 - Aspirating and dispensing small volumes of liquids: A metering device for aspirating and dispensing a liquid includes a housing; a pumping medium, preferably a gas containing chamber contained within the housing; a channel having a proximate end in fluid communication with the chamber and a distal end in fluid communication with an external environment; a heat or... Agent: Philip S. Johnson Johnson & Johnson

20090093066 - Glycated peptides and methods of use: The invention provides glycated peptides and glycated fragments and glycated variants thereof, antibodies and aptamers which bind thereto, compositions and kits comprising the same, related conjugates, and a database comprising data indicating the concentration of glycated peptides present in diabetic and non-diabetic persons. The invention also provides a method of... Agent: Leydig, Voit & Mayer, Ltd.

20090093068 - Immunosensor and measuring method using the same: An immunosensor includes a base body (101) having a sample holding portion (102) which holds a test sample, a sample introducing port (103) which is communicated with the sample holding portion (102) and through which the test sample is introduced to the sample holding portion (102), a dried first reagent... Agent: Mcdermott Will & Emery LLP

20090093067 - Methods for making and using spr microarrays: An article, process, and method for surface plasmon resonance plates are described. A substrate is covered with a thin metal film onto which a second thin metal film is deposited. The surface of the second thin metal film is converted to the metal oxide which is used to covalently bond... Agent: Graybeal Jackson LLP

20090093069 - Topiramate immunoassays: Diacetonefructose derivatives have substituents at the hydroxyl-position. Diacetonefructose derivatives may include immunogenic moieties to prepare anti-diacetonefructose derivative antibodies, or antigenic moieties for immunodiagnostic assays. Also, the diacetonefructose derivatives can include signal generating moieties for detecting the presence or amount of the diacetonefructose derivative in a sample. Additionally, the diacetonefructose derivatives... Agent: Morgan, Lewis & Bockius LLP (sf)

20090087911 - Coded optical emission particles for subsurface use: Tagging system and method including a plurality of particles, each particle having a miniature body and configured to provide a non-radioactive resolvable optical emission in a distinguishable pattern when selectively illuminated. The particles are set for selective release to a subsurface location. An apparatus having an elongated body configured for... Agent: Schlumberger Reservoir Completions

20090087912 - Tagged particles for downhole application: A tagged object includes a main body and a plurality of coded particles. Each coded particle may have a miniature body and be configured to provide a resolvable optical emission pattern when illuminate. The plurality of coded particles may be immobilized to the main body. A method for performing oilfield... Agent: Schlumberger Reservoir Completions

20090087913 - Analysis of conjugated metabolites of alcohol consumption: A method, system, kit and uses for quantifying and normalizing at least one product of ethanol metabolism are provided. A method is provided for quantifying and normalizing at least one product of ethanol metabolism in a sample comprising creatinine. The method comprises adding a predetermined amount of at least one... Agent: Ralph A. Dowell Of Dowell & Dowell P.C.

20090087915 - Analyzer and communication method: An analyzer for analyzing a specimen includes a central control unit that instructs systems of the analyzer of a process operation; and a primary control unit that time-divisionally outputs an instruction by the central control unit. The analyzer also includes a plurality of secondary control units; a communication connection unit;... Agent: Scully Scott Murphy & Presser, PC

20090087914 - Automatic analyzing apparatus and quality control method for analysis supporting liquid in the same: An automatic analyzing apparatus can properly determine a quality of an analysis supporting liquid, after being supplied to the automatic analyzing apparatus, which supports an analysis performed in the automatic analyzing apparatus and can properly maintain an accuracy of the analysis. The analysis supporting liquid which supports an analysis of... Agent: Scully Scott Murphy & Presser, PC

20090087916 - Assay method for identifying drug candidate: The present invention provides a method of identifying a drug candidate capable of removing peptide, oligopeptide, polypeptide or protein from fibril or aggregate, which includes measuring, in the presence of a test compound, the concentration of a soluble peptide, a soluble oligopeptide, a soluble polypeptide or a soluble protein in... Agent: Banner & Witcoff, Ltd.

20090087917 - Automated protein analyzer: A protein analysis instrument and method are disclosed. The method includes mixing a binding dye composition and a protein sample using a homogenizer, measuring a parameter selected from the group consisting of the speed of the homogenizer and the resistance of the mixture to the homogenizer, adjusting the speed of... Agent: Summa, Additon & Ashe, P.A.

20090087918 - Differentiation of acute and chronic myocardial necrosis in symptomatic patients: The present invention relates to a method for diagnosing an acute cardiovascular event comprising the steps of determining the amount of a cardiac troponin in a sample of a subject, determining the amount of a natriuretic peptide in a sample of said subject and diagnosing an acute cardiovascular event by... Agent: Roche Diagnostics Operations Inc.

20090087919 - Method and apparatus for measuring protein post-translational modification: The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least... Agent: Lawrence R. Oremland, P.C.

20090087920 - Method and apparatus for assessing blood-concentration of a volatile constituent: A method and apparatus for of assessing the blood concentration level in a human or animal subject, of a volatile blood constituent (preferably alcohol) is disclosed. The method comprises steps of positioning a sensor (21, 22) within the expiratory gas flow of the subject, wherein the sensor (21, 22) is... Agent: Brinks Hofer Gilson & Lione

20090087921 - Vaporized hydrogen peroxide concentration detector: A method of determining the presence of vaporized hydrogen peroxide (VHP) in a region, comprising the steps of providing a sealable region having an inlet port and an outlet port, creating a flow of a carrier gas into, through and out of the region, delivering vaporized hydrogen peroxide into the... Agent: Kusner & Jaffe Highland Place Suite 310

20090087923 - Method of high sensitive immunoassay: An object of the present invention is to provide a method of high sensitive immunoassay using immunoagglutination reaction by antigen-antibody reaction for quantification of thyroid stimulating hormone (TSH). The present invention provides a method of assaying a thyroid stimulating hormone (TSH) comprising assaying agglutination which is generated by contacting TSH... Agent: Birch Stewart Kolasch & Birch

20090087922 - Single nucleotide polymorphism analysis of highly polymorphic target sequences: Methods and probes are provided for the analysis of target sequences having two or more polymorphisms wherein one of the polymorphisms is to be distinguished and another polymorphism is to be masked.... Agent: Townsend And Townsend And Crew, LLP

20090087925 - Devices and methods for analysis of samples with depletion of analyte content: A system and method for determining the presence and/or concentration of one or more analytes in a sample that comprises a fluid, the system comprising a solid substrate comprising a sample inlet or inlets and one or more analyte determination flow paths, each analyte determination flow path comprising a defined... Agent: King & Spalding LLP

20090087927 - Immunochromatography method using fragmented antibody: An object of the present invention is to overcome the problem of nonspecific adsorption of a labeled antibody on the detection site and to provide an immunochromatography method by which the false positive signal can be suppressed, and wherein the detection sensitivity is high and the highly reliable measurement can... Agent: Birch Stewart Kolasch & Birch