Chemistry: analytical and immunological testing inventions 02/09

20090053814 - Microfluidic apparatus and method for sample preparation and analysis: The pumps (Pn) are operated to transport individual reagent streams into the chip in a non-pulsatile, laminar flow regime at low flow rates permitting lows grading from 0 to as little as 5 nl/min with a precision of 0.1 nl/min. In the chip (MFC), the reagent streams are merged and... Agent: Eksigent Technologies, LLC C/o Sheldon Mak Rose & Anderson

20090053815 - Use of holographic sensors: A method of measuring the amount of an analyte in a sample, comprises (a) passing the sample through a flow channel in or on a holographic sensor, wherein the analyte interacts with and is retained by the sensor and wherein the interaction of the analyte changes an optical property of... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090053816 - Hemoglobin-based methods for prophylaxis, diagnosis and/or treatment of retinal disorders: The presently disclosed subject matter provides methods of diagnosing retinal disorders in subjects by measuring hemoglobin and modified hemoglobin in the subjects. The presently disclosed subject matter further provides methods of treating retinal disorders in subjects by decreasing hypoxia in retinal tissue of the subjects through modulation of hemoglobin levels... Agent: Stites & Harbison, PLLC

20090053817 - Fixed charge reagents: The present invention relates to fixed charge reagents and kits for use in tandem mass spectrometry methods involving multiplex analysis. The compounds of the invention are phenacylamide compounds. The invention also relates to methods for the quantification of for example peptides and proteins by tandem mass spectrometry techniques using said... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20090053819 - Methods and systems for protein and peptide evidence assembly: The present teachings provide methods and systems for the identification of proteins via peptide analysis. Some embodiments analyze proteins identified by analysis techniques such as mass spectrometry and build protein groups out of results. Groups can be formed by collecting like proteins and examining the group so as to identify... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090053818 - Quantitative proteomics with isotopic substituted raman active labeling: A labeling reagent having a distinct Raman, or surface enhanced Raman, spectral signature is used for the control and analysis samples. The labeling reagents can be fluorescent dyes with different isotopic substituents, such as the substitution of some hydrogen atoms for deuterium atoms. Such labeling does not have any detectable... Agent: Coleman Sudol Sapone, P.C.

20090053821 - Fluorescence quenching azo dyes, their methods of preparation and use: Disclosed is a group of azo quencher compositions useful as fluorescence quenchers having the general structure of formula 1, methods of making or using the compositions, and kits comprising the composition.... Agent: Michael Best & Friedrich LLP

20090053820 - Two-step nucleic acid testing method using the same sample: The present invention provides a method of testing whether a sequence of interest is contained in a sample nucleic acid or not, comprising performing a simple test on the sample nucleic acid and subjecting the same sample nucleic acid to a close examination when it has been judged that the... Agent: Birch Stewart Kolasch & Birch

20090053822 - Method and pd/v2 o5 device for h2 detection: Methods and Pd/V2O5 devices for hydrogen detection are disclosed. An exemplary method of preparing an improved sensor for chemochromic detection of hydrogen gas over a wide response range exhibits stability during repeated coloring/bleaching cycles upon exposure and removal of hydrogen gas. The method may include providing a substrate. The method... Agent: Paul J White, Patent Counsel National Renewable Energy Laboratory (nrel)

20090053823 - Liquid reagent of color former and method of stabilizing the same: A liquid reagent in which a methylene blue compound color former is stably stored in a liquid state; and a method of stabilizing a methylene blue compound color former in a liquid state. A methylene blue compound color former is stabilized by causing it to coexist with either a quaternary... Agent: Hamre, Schumann, Mueller & Larson, P.C.

20090053824 - Assay device processing apparatus and method: Assay device processing apparatus includes a rotatably mounted assay device vessel support; and a drive for rotating the support. The support is rotatable about a substantially horizontal first axis so that, upon rotation, an assay device vessel attached to the support can be inverted.... Agent: Oliff & Berridge, PLC

20090053829 - Absorption pad for immunoassay, strip for immunoassay and immunoassay apparatus: Providing an absorption pad which shows remarkable water absorptivity and can shorten a detection time when employed for an immunoassay apparatus. A water absorption pad for the immunoassay apparatus, containing 50% by weight or more of silicon-containing particles wherein a moisture absorptivity is 30% or less at a humidity of... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090053827 - Assay device and method: An assay device includes a first reagent including a magnetic particle and a second reagent including detectable component. The first and second reagent can each independently bind to an analyte in a sample. A time-varying magnetic field can be used to distinguish detectable components that are associated with analyte from... Agent: Steptoe & Johnson LLP

20090053830 - Blood test kit: A blood crossmatching apparatus, kit and methods for testing the compatibility of mammals for blood transfusion. Particulate layers in the apparatus allow nonagglutinated red blood cells to permeate through, while agglutinated red blood cells cannot. The apparatus also has a density solution. The density solution separates white blood cells from... Agent: Fraser Trebilcock Davis & Dunlap, P.C.

20090053828 - Detection of glycopeptides and glycoproteins for medical diagnostics: A diagnostic method for determining the absence or presence of a disease is provided. The method includes assaying the amount and/or types of glycopeptides in a sample from a subject, and comparing these to the amount and types of reference glycopeptides. The method may include the use of a stable... Agent: Brinks Hofer Gilson & Lione

20090053826 - Electropolymerisable monomers that are soluble in aqueous solution and electroactive probes that can be obtained with such monomers: The invention relates to an electropolymerizable monomer, intended to be polymerized in aqueous solution, comprising a single electropolymerizable unit and an electron-donating group, characterized in that it also comprises at least one arm ionizable in aqueous solution. The invention also relates to the polymerization process, to the electroactive probe thus... Agent: Oliff & Berridge, PLC

20090053825 - Molecular recognition polymer enabling reconstruction of recognition field for target molecule and method of producing the same: A molecular recognition polymer enabling the reconstruction of the recognition field for a target molecule which is produced by applying the molecular imprinting method is disclosed. A molecular recognition polymer enabling the reconstruction of the recognition field for a target molecule which has a molecule interacting with the target molecule... Agent: Harness, Dickey & Pierce, P.L.C

20090053831 - Tyrosine phosphorylation sites: The invention discloses 405 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.... Agent: Simona Levi-minzi, Ph.d. General Counsel

20090053832 - Simultaneous assay for determining drugs: e

20090047743 - Method and system for determining residual chlorine or chloramine concentration in solution by colorimetey: A kit for determining residual chlorine or chloramine amount of a sample; comprising: a means for containing a PVA solution as an indicator, and another means for containing a reducing indicator. Said reducing indicator would be oxidized by a reaction with residual chlorine or chloramine and said PVA indicator induces... Agent: Barry Choobin

20090047744 - Method for improving the characterisation of a polynucleotide sequence: A method of identifying at least one characteristic of a target molecule comprises the steps of: (i) converting the at least one characteristic into a signal polynucleotide; and (ii) identifying the signal polynucleotide sequence, thereby identifying the at least one characteristic of the target molecule wherein each signal polynucleotide comprises... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20090047745 - Bulk negative index of refraction materials with response in the visible: Bulk negative refractive index materials (NIM) or left-handed metamaterials (LHM) as an amorphous and isotropic solid material consisting of mutually electrically insulated synthetic rings or pucks smaller than the wavelength of visible light. Each ring or puck contains a nanometer sized metallized nucleic acid ring containing one or more non-metallized... Agent: Greenlee Winner And Sullivan P C

20090047746 - Analytical method and analytical apparatus: [PROBLEMS] To reduce the amount of, for example, a capturing antibody to be employed without lowering detection sensitivity. At the same time, to enable the achievement of intense color development or light emission in a determination area even in the case where only a small amount of a labeled antibody... Agent: Kanesaka Berner And Partners LLP

20090042303 - Method for measuring the concentration of a glycosaminoglycan anticoagulant: The invention provides an accurate, economical, automatable, high throughput method for the determination of the concentration of glycosaminoglycan anticoagulants, including low molecular weight heparin (LMWH) anticoagulants, in aqueous solutions. A method for cleaning a unit of manufacturing equipment used in the preparation of a LMWH to obtain an acceptable residual... Agent: Leydig Voit & Mayer, Ltd

20090042304 - Method for analyzing foods: A method for using stable isotope profiling and optionally trace element profiling to differentiate the origin of commodities, such as pistachios (Pistachia vera), or salmon, is disclosed. Isotope ratios can be determined using any suitable method, such as stable isotope mass spectrometer. Geographic regions were well separated based on isotope... Agent: Klarquist Sparkman, LLP

20090042305 - Sensor release mechanism for a test meter: A sensor-dispensing instrument adapted to handle a sensor pack containing a plurality of sensors and to perform a test using one of the sensors. The sensor dispensing instrument includes an outer housing and a mechanical mechanism contained therein for rotating the sensor pack and ejecting one of the sensors from... Agent: Nixon Peabody LLP

20090042306 - System and method for automatic calibration: A device includes a sensor array and a processor is automatically calibrated. The sensor array collects data from a pattern using at least one of a capacitive measurement and a radio frequency measurement. The pattern is included on a calibration storage device. The processor receives the data from the sensor... Agent: Fay Kaplun & Marcin, LLP

20090042307 - Hydrophilic polymer microparticle, filler for ion exchange liquid chromatography, and method for production of filler for ion exchange liquid chromatography: The present is a hydrophilic polymer microparticle, which has a DW/DA ratio of 2.0 or less, the DW representing a particle diameter of the hydrophilic polymer microparticle dispersed in water, the DA representing a particle diameter of the hydrophilic polymer microparticle dispersed in acetone, each of the particle diameters measured... Agent: Wenderoth, Lind & Ponack, L.L.P.

20090042308 - Method for isolating and modifying dna from blood and body fluids: This invention is related to a method and assay kit for rapidly quantifying global DNA methylation through immobilizing DNA by simple dry-capture on the plastic carrier followed by immunodetection of 5-methylcytosine structure that is the marker of DNA methylation.... Agent: Weiwei. Li

20090042309 - Breath test for total organic carbon: A total amount of volatile organic compounds (VOCs) in a breath sample (101) is detected by oxidizing/burning (120) the VOCs to form CO2 and H2O, and the amounts of one or both of these compounds are measured (130). CO2 and H2O molecules in the breath sample (101) are removed (110)... Agent: Philips Intellectual Property & Standards

20090042310 - Particle quantifying systems and methods using acoustic radiation pressure: The present invention comprises methods and systems that use acoustic radiation pressure.... Agent: Peacock Myers, P.C.

20090042311 - Analyte sensor devices and holders, and methods and systems utilizing the same: Provided are sensor devices, methods, systems, and kits for measuring the concentration of at least one target analyte. Sensor devices may be mounted into an optical system for measuring the target analyte. Example sensor devices may also be removably mounted in a holder that enables the sensor device to be... Agent: Castellano PLLC

20090042312 - Test method for determining compounds capable of quenching electronic singlet state excitation of photoactive compounds: A method of testing a compound for its capability of quenching singlet excited state energy from a photon-excited photoactive compound, thereby photostabilizing said photoactive compound, comprising mixing: (1) a composition comprising a photoactive compound in a solvent and determining the degree of fluorescence of said composition (1) by exposing the... Agent: Marshall, Gerstein & Borun LLP

20090042313 - Recording assay device: The invention herein described relates to an assessment device comprising an assay part and a detachable recording part. The assessment device facilitates the rapid assaying and processing of tissue/fluid samples by healthcare workers. Also, advantageously, the result of the assay is only apparent to the healthcare worker after interrogation of... Agent: Standley Law Group LLP

20090042315 - Compositions of specific binding agents to hepatocyte growth factor: Compositions comprising nonpolar amino acids and specific binding agents to hepatocyte growth factor (HGF) are provided. Methods of making and using such compositions are also provided.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090042314 - Lanthanide-doped nayf4 nanocrystals, method of preparing and uses thereof: The present invention relates to a method of preparing lanthanide-doped NaYF4 nanocrystals, the method comprising: (A) providing a first solution comprising a non-coordinating solvent, a fatty acid coordinating ligand, sodium trifluoroacetate, yttrium trifluoroacetate, a first doping lanthanide trifluoroacetate and a second doping lanthanide trifluoroacetate, and a second solution comprising the... Agent: Goudreau Gage Dubuc

20090042316 - Use of perfluoropolymers in the determination of the receptor-ligand binding constant: Use of flat surfaces comprising perfluorinated polymers in the determination of the binding constant of two interacting molecular species by using measurements of reflected light intensity, said surface comprising at least one molecule with the receptor function adsorbed or immobilized on said surface, and at least one ligand which interacts... Agent: Arent Fox LLP

20090042317 - Substance immobilizing apparatus, substance detecting apparatus and substance immobilizing method: The efficiency of the specific binding of a target substance to an immobilization region is increased. As a first step, target substance 1001 is drawn to immobilization region 1003 on which immobilized substance 1002 to which target substance 1001 can specifically bind is immobilized. As a second step, only target... Agent: Fitzpatrick Cella Harper & Scinto

20090042318 - Method for effective search for target molecule: The present invention provides a solid phase carrier capable of adsorbing a highly hydrophobic target molecule, for example, a membrane associated protein, and a solid phase carrier optimized not only for a highly hydrophobic target molecule, but also for an optionally chosen target molecule. More specifically, the present invention provides... Agent: Leydig Voit & Mayer, Ltd

20090042319 - Biosensor detection by means of droplet driving, agitation, and evaporation: Methods of improving microfluidic assays are disclosed. Assays can be improved (better signal to noise ratio) by using sessile drop evaporation as an analyte concentration step (enhanced signal) and repeated passes of wash droplets as a means to reduce non-specific binding (noise reduction). In addition multiple massively parallel analyses improve... Agent: Stefan Kirchanski

20090035867 - Automatic analyzer and method for using the same: An automatic analyzer comprises: a reaction unit including a plurality of vessels; a first reagent storing unit that is capable of storing a plurality of reagent cassettes; a sample dispenser for dispensing a sample into the reaction unit; a reagent dispenser for dispensing a reagent corresponding to an analysis item... Agent: Mattingly, Stanger, Malur & Brundidge, P.C.

20090035868 - Rapid protein labeling and analysis: The present invention provides methods and compositions for labeling, separating and analyzing proteins, particularly a specific protein of interest within a cell lysate or in a mixture of proteins. The proteins are labeled with an amine reactive or thiol reactive fluorescent dye, or an amine reactive fluorogenic reagent that becomes... Agent: Invitrogen Corporation C/o Intellevate

20090035869 - Method and system for genetic pattern recognition: A method and an system for the detection of nucleic acid oligonucleotides is characterized in that said detection corresponds to a capacitive reading of the melting point of complexes obtained by hybridization of said oligonucleotides and suitably modified molecules of oligonucleotide probes.... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20090035870 - Particle sensor: A particle sensor is provided having a first temperature sensing device having a sensing surface exposed to particles contained within a fluid. The sensing surface is at least partially coated with a catalyst for promoting an exothermic reaction with at least a portion of the particles. The particle sensor also... Agent: Caterpillar/finnegan, Henderson, L.L.P.

20090035872 - Fluidics system: The present invention provides a fluidics system and a method for selectively drawing fluid from at least one selected reservoir into a channel by providing a negative pressure source downstream of the fluid and channel and selectively back filling the selected reservoir with a gas.... Agent: Naval Research Laboratory Associate Counsel (patents)

20090035876 - Electrochemical assay: A method of determining the presence or amount of analyte in a fluid sample, which comprises: contacting a fluid sample with a binding reagent that comprises a plurality of cleavable species and wherein said species, when cleaved, are detectable using electrochemical means; separating any binding reagent-analyte complex that forms from... Agent: Nixon & Vanderhye, PC