Chemistry: analytical and immunological testing inventions 01/09

20090029472 - Apparatuses and media for drug elution and methods for making and using them: Embodiments of the invention provide to apparatuses and media used in drug elution studies and methods for making and using them. Such methods and materials can be used for example to assess and control the manufacturing process variability of drug eluting implantable devices such as cardiac leads. One embodiment of... Agent: Gates & Cooper LLP Howard Hughes Center

20090029473 - Lipid profile as a biomarker for early detection of neurological disorders: The present invention relates to compositions and methods for the early detection or monitoring of neurodegenerative diseases and neurological disorders including Alzheimer's disease. The invention provides biomarkers based on lipid profiles of biological samples and methods for using the biomarkers for the detection of neurodegenerative diseases and neurological disorders.... Agent: Polsinelli Shalton Flanigan Suelthaus Pc

20090029474 - High throughput screening methods for lubricating oil compositions: A method for determining oxidation stability for a plurality of different lubricating oil composition samples is provided. The methods can advantageously be optimized using combinatorial chemistry, in which a database of combinations of lubricating oil compositions is generated. As market conditions vary and/or product requirements or customer specifications change, conditions... Agent: M. Carmen & Associates, Pllc

20090029475 - Method for determining the content of diesel fuel in a lubricating oil of a combustion engine: m

20090029476 - Reaction vessel, analyzer, and method of analysis: A reaction vessel includes a storage space extending from a first end to a second ends the reaction vessel being configured to retain at least one of a reagent and a specimen in the storage space when the at least one of the reagent and the specimen is dispensed from... Agent: Scully Scott Murphy & Presser, Pc

20090029478 - Detection of target molecules through interaction with probes: A method for detecting a target nucleic acid molecule or target nucleic acid molecular complex comprising: (a) contacting two or more probes complementary to the molecule or molecular complex, said molecule or molecular complex being labeled with one or more fluorescent dye molecules of the same dye or labeled with... Agent: Wilson Sonsini Goodrich & Rosati

20090029477 - Ultra high-throughput opti-nanopore dna readout platform: Described herein are methods for analyzing polymer molecules. These methods are employed for the high throughput readout of DNA and RNA molecules with single molecule sensitivity. The method of the present invention comprises (1) the electrically controlled unzipping of DNA (or RNA) double strands, and (2) the readout of the... Agent: Fish & Richardson Pc

20090029479 - Test strip and connector: An analyte test strip is provided that includes a generally planar substrate and a plurality of conductive areas disposed on the substrate to define five distinct conductive portions comprising at least five contact lands defining respective vertices of a polygon, and in which two contact lands are located in a... Agent: Philip S. Johnson Johnson & Johnson

20090029480 - Testing device: A device for testing for the presence of an analyte, the device comprising at least one reagent adapted to provide a calorimetric indication in the presence of the analyte, a catalyst to catalyse the reaction providing the calorimetric indication, and where there is provided one reagent, means for substantially inhibiting... Agent: Renner Kenner Greive Bobak Taylor & Weber

20090029481 - Method for separating target component using magnetic nanoparticles: An object to be achieved by the present invention is to provide a method for determining the amount of a component contained in a specific lipoprotein fraction in a biological sample using an automatic analyzer, without the requirement of a step of fractionating a sample by centrifugation. The present invention... Agent: Birch Stewart Kolasch & Birch

20090029482 - Functional particle, and method for separation of target substance using the same: The particles of the present invention are high density particles which enable a preferential binding of a target substance thereto and inhibit a binding of “substances other than the target substance” thereto. The particles of the present invention are characterized in that a substance or functional group capable of binding... Agent: Birch Stewart Kolasch & Birch

20090029483 - Reagent for latex aggregation reaction and method for detecting target substance: e

20090029484 - Novel hemopoietin receptor protein, nr12: A novel hemopoietin receptor gene (NR12) was successfully isolated by extracting motifs conserved among the amino acid sequences of known hemopoietin receptors and by using the predicted sequence. The NR12 gene encodes two forms of proteins, a transmembrane type and a soluble type. The expression of the NR12 gene was... Agent: Fish & Richardson Pc

20090023217 - Integrated chemical indicator device: A chemical indicator device for use in detecting exposure to an oxidizing agent, such as hydrogen peroxide, comprising a substrate or support upon which is disposed a chemical indicator composition (ink) for detecting an oxidizing agent, such as hydrogen peroxide. The chemical indicator composition further comprises an indicator dye that... Agent: Hudak, Shunk & Farine, Co., L.p.a.

20090023218 - Test method for determining etch performance of coated substrate: The present invention provides a test method for simulating outdoor exposure conditions for testing a coated substrate to evaluate environmental etching of paint caused by acid rain. The test method requires that the test substrate have an acid solution having a pH of less than 6.0 applied thereto by spray... Agent: Harness, Dickey And Pierce, P.L.C

20090023219 - Specimen gathering device and method of use: A kit is provided for gathering biological specimens. The kit generally comprises a self-contained specimen gathering device including a protective housing and a preservation solution. Also provided is a method of gathering specimens and a holistic method of deterring crime using the kit.... Agent: Barnes & Thornburg LLP

20090023220 - Method for discriminating between prostatic cancer and benign prostatic hyperplasia: The present invention provides a method for accurately discriminating between prostate carcinoma and benign prostatic hyperplasia based on a glycan structure of prostate specific antigen (PSA). The method of the present invention includes the steps of: purifying PSA from a sample derived from a subject; preparing a PSA derivative from... Agent: Oliff & Berridge, Plc

20090023221 - Oligonucleotide probes useful for detection and analysis of microrna precursors: The invention relates to ribonucleic acids and oligonucleotide probes useful for detection and analysis of microRNA precursors and their targets. The invention furthermore relates to oligonucleotide probes for detection and analysis of other non-coding RNAs, mRNAs, mRNA splice variants, allelic variants of single transcripts, mutations, deletions, or duplications of particular... Agent: Clark & Elbing LLP

20090023222 - Temperature-adjusted analyte determination for biosensor system: A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations... Agent: Blanchard & Associates

20090023223 - Plug flow system for identification and authentication of markers: Devices and methods for extraction, identification, authentication, and quantification of one or more covert markers in a material are disclosed. An extraction system includes a first plug flow mixer for mixing a first fluid bearing a marker and transfer agent into a plug flow. The mixing and flowing of the... Agent: Fish & Richardson P.c.

20090023228 - Dual-acting imidazole antihypertensive agents: wherein: Ar, r, R2-3, X, and R5.7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for... Agent: Theravance, Inc.

20090023227 - Method: The invention provides a method of measuring the affinity of first and second biomolecules in which a first biomolecule is tethered by a first tether portion having a first tether portion length and a second biomolecule is tethered by a second tether portion having a second tether portion length, the... Agent: Hunton & Williams LLP Intellectual Property Department

20090023225 - Methods and devices for analyte detection: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.... Agent: Morgan, Lewis & Bockius, LLP.

20090023226 - Variant integrin polypeptides and uses thereof: Polypeptides comprising all or part of a variant integrin α subunit A domain and its flanking region are described. In solution or in membrane-associated form, the A domain polypeptides of the invention exists predominantly in a high affinity conformation. In the polypeptides of the invention, referred to as variant integrin... Agent: Fish & Richardson Pc

20090023224 - Vascular endothelial growth factor 2: Disclosed are human VEGF-2 antibodies, antibody fragments, or variants thereof. Also provided are processes for producing such antibodies. The present invention relates to methods and compositions for preventing, treating or ameliorating a disease or disorder comprising administering to an animal, preferably a human, an effective amount of one or more... Agent: Sterne, Kessler, Goldstein & Fox P.l.l.c.

20090017544 - Automatic analyzer and analysis method using the same: Disclosed herein is an automatic analyzer which determines a vessel blank value of the automatic analyzer based on a criterion associated with the sensitivity of an analysis item to determine whether or not a vessel is usable. An automatic analyzer includes: an operation unit for calculating an absolute value of... Agent: Mattingly, Stanger, Malur & Brundidge, P.C.

20090017545 - Method of determining metal by colorimetry and determination reagent: The present invention is a method for calorimetrically determining a metal in a sample using a chelating coloring agent, characterized by coexistence of a masking agent for iron, copper or nickel. Also, the present invention is a reagent for calorimetrically determining a metal in a sample using a chelating coloring... Agent: Jordan And Hamburg LLP

20090017546 - Fluorescent isotope tags and their method of use: The present invention provides novel reactive fluorescent compounds that incorporate stable isotopic (deuterium, 13-carbon, 15-nitrogen, 18-oxygen) substitutions. The invention includes the use of these compounds, in combination with non-isotopically substituted analogs, for the purification, identification and relative quantification of proteins, peptides, saccharides, metabolites, and other biologically important compounds by combining... Agent: Invitrogen Corporation C/o Intellevate

20090017547 - Systems and methods for dna computing using methylation: The present disclosure is directed to new methods and systems performing flexible and reversible modification of DNA in order to establish the logical value of true or false for a set of clauses. It combines both the biological meaning and experimental procedure with the logical implementation of the basic Boolean... Agent: Philips Intellectual Property & Standards

20090017548 - Method for determining the effectiveness of stabilized chlorine dioxide in a mouth rinse: A method for determining the available treatment dosage of stabilized chlorine dioxide in the prevention and the treatment of plaque accumulation, volatile sulfur compound production, gingivitis and periodontitis, and for differentiating the treatment dosage from other chlorine-containing compounds that may not have such beneficial effects is disclosed. When in solution... Agent: C. Robert Von Hellens Cahill, Von Hellens & Glazer P.L.C

20090017549 - Apparatus and method for determining the concentration of iodine-containing organic compounds in an aqueous solution: A method for determining the amount of a known iodine-containing organic compound in an aqueous solution. The method comprises electrochemically reducing the known iodine-containing organic compound in an aqueous medium to release iodide anions, chemically oxidizing the iodide anions to produce molecular iodine, and measuring the amount of molecular iodine.... Agent: Streets & Steele

20090017550 - Method for determining a carbon source of a product: This invention is directed to a method for determining a source of carbon feed used in manufacturing product produced from the carbon feed. The invention further provides a method for tracking products, particularly MTO products, derived from a particular carbon feed. In general, the method involves a variety of steps... Agent: Exxonmobil Chemical Company Law Technology

20090017551 - Method and device for the detection of hydrogen: The present invention relates to a device and a method for the detection of hydrogen in a gas volume by means of an exothermal catalytic recombination of hydrogen and oxygen present in the gas volume into water. The amount of energy that is released during such an exothermal catalytic recombination... Agent: Harness, Dickey & Pierce, P.L.C

20090017554 - Detection and mixing in a conduit in integrated bioanalysis systems: Apparatuses and methods in which detection is integrated with various liquid processing and environmental control functions to create integrated bioanalysis systems are disclosed. Though the various integrated bioanalysis systems are useful for any number of analysis formats, they are adaptable to high-throughput processing of samples.... Agent: Mila Kasan, Patent Dept. Applied Biosystems

20090017552 - Fluorescein based sensors for tracking nitric oxide in live cells: The present invention is directed, in part, to coordination complexes for detecting analytes, and methods of making and using the same.... Agent: Foley Hoag, LLP Patent Group, World Trade Center West

20090017553 - Immunoassay-based microsensing using optical sensors: A biosensor device, system, and method for detecting biological material. The sensor includes a substrate including sample regions having attachable thereon an immobilized first species associated with the biological material and includes at least one optical sensor associated with the sample regions and configured to detect induced radiation from a... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20090017558 - Apolipoprotein e stable folding intermediate and methods of use thereof: The present invention provides isolated apolipoprotein E (apoE) stable folding intermediates. The invention further provides methods for identifying compounds that alter the structure or level or activity of an apoE stable folding intermediate, as well as methods of inhibiting the formation or activity of stable folding intermediates of apoE. The... Agent: Bozicevic, Field & Francis LLP

20090017555 - Delta-9-tetrahydrocannabinol detection method: The invention provides competitive immunoassay techniques for high sensitivity detection of delta-9-tetrahydro-cannabinol (cannabis; THC) employing a carrier conjugate of an intermediate in the biosynthesis of cannabis, more particularly 5-pentylresorcinol conjugated to a macromolecular carrier via its hydroxyl groups. By employing such a conjugate with anti-THC antibody in a lateral flow... Agent: Morrison & Foerster LLP

20090017557 - Fvii specific antibodies and use thereof: The present invention relates to novel antibodies against FVII, use for determining amount of correctly folded and intact FVII in a sample, as well as for purification and process optimization.... Agent: Novo Nordisk, Inc. Intellectual Property Department

20090017556 - Methods and complexes involving immunoglobulin molecule: A device that includes a proteinaceous factor is disclosed. The proteinaceous factor is encoded by the nucleotide sequence of any one of SEQ ID NO.: 1, a degenerate variant of SEQ ID NO.: 1, and a complement of SEQ ID NO.: 1. The proteinaceous factor may be a recombinant. In... Agent: Smith Moore Leatherwood LLP

20090017559 - Methods for diagnosing renal disorders: The present invention relates to methods for diagnosing the presence and progress of pathologies characterized by an accumulation of the extracellular matrix components by measuring the level of Connective Tissue Growth Factor (CTGF) in a sample. The method of the present invention is directed to diagnosing kidney fibrosis and associated... Agent: Fibrogen, Inc. Intellectual Property Department

20090017560 - Cardiovascular autoimmune disease panel and methods of using same: Provided herein among other things are diagnostic tests, methods of use, and kits for the assessment and management of cardiovascular autoimmune disease and risk of cardiovascular autoimmune disease. Assay methods of the invention can be employed among other things to identify cardiovascular autoimmune disease, or risk thereof, in subjects who... Agent: Paul D. Yasger Abbott Laboratories

20090017561 - Labelled silica nanoparticles for immunochromatographic reagent, immunochromatographic reagent, immunochromatographic test strip using the same, and immunochromatographic fluorescence-detecting system or radiation-detecting system: Labelled silica nanoparticles for immunochromatographic reagent, comprising silica nanoparticles containing a labelled substance.... Agent: Birch Stewart Kolasch & Birch

20090017562 - Raman-active reagents: Raman Active Reagents (ERLs) are developed which use a nanoparticle substrate substantially covered with a mixed monolayer derived from a Raman active reporter molecule and an analyte binding molecule that both bind to the surface of the nanoparticle and thereby avoid the necessity for separate synthesis of a bifunctional linker... Agent: Mckee, Voorhees & Sease, P.L.C

20090011511 - Single-point genome signature tags: Disclosed is a method for analyzing the organismic complexity of a sample through analysis of the nucleic acid in the sample. In the disclosed method, through a series of steps, including digestion with a type II restriction enzyme, ligation of capture adapters and linkers and digestion with a type IIS... Agent: Brookhaven Science Associates/ Brookhaven National Laboratory

20090011512 - Conditioning system and method for use in the measurement of mercury in gaseous emissions: Embodiments of the invention relate generally to systems used to measure mercury in gaseous emissions. In one aspect, the invention is directed to the use of silicon carbide as material for a thermal pyrolysis unit. In another aspect, at least one of silicon nitride, silicon boride, and/or boron nitride is... Agent: Bereskin And Parr

20090011514 - Dna crosslinking for primer extension assays: Provided herein are compositions and methods for inhibiting false signals associated with mispriming in primer extension assays.... Agent: Womble Carlyle Sandridge & Rice, PLLC

20090011513 - Method of detecting nucleic acid by using nucleic acid microarray: The present invention provides a method of detecting a nucleic acid which is not restricted by the design of the base sequence of a nucleic acid probe. By repeating washing and detection in multiple stages, the present invention can improve the precision of sequence-specific hybridization stepwise and also can ease... Agent: Darby & Darby P.C.

20090011515 - Control of n-(phosphonomethyl)iminodiacetic acid conversion in manufacture of glyphosate: This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content.... Agent: Senniger Powers LLP

20090011516 - Methods and assays for the detection of nitrogen uptake by a plant and uses thereof: The invention provides a rapid and efficient method and assay for monitoring nitrogen uptake by a plant using a pH indicator. The plant is exposed to medium comprising one or more sources of nitrogen, such as nitrate or ammonia, and a pH indicator. The plant is exposed to the source... Agent: Pioneer Hi-bred International, Inc.

20090011517 - Sample plate for fluid analysis in a refinery process: A sample plate for use with a portable apparatus containing at least two different analytical devices, said plate (1) comprising (i) a receiver (2) for a fluid to be analysed; (ii) at least two fluidic channels (6, 7) each adapted to transfer a portion of said fluid or a component... Agent: Nixon & Vanderhye, PC

20090011518 - Device and method for detection of fluorescence labelled biological components: A sample acquiring device for detection of biological components in a liquid sample is provided comprising a measurement cavity for receiving a liquid sample, wherein the measurement cavity has a predetermined fixed thickness, and a reagent, which is arranged in a dry form inside the measurement cavity. The reagent comprises... Agent: Buchanan, Ingersoll & Rooney PC

20090011519 - Device and method for micro sorbent extraction and desorption: This invention relates to a micro cartridge and to a method of using the micro cartridge to sample and extract components of interest from a gas or a liquid. The cartridge contains a sorbent and has passages through which a pressure drop can be created to permit access between the... Agent: Borden Ladner Gervais LLP Anne Kinsman

20090011520 - Stable d-dimer liquid preparation: The invention is in the field of coagulation diagnosis and relates to a liquid, buffer-based D-dimer composition, which additionally contains fibrinogen and which is suitable as a standard material for control or calibration purposes for D-dimer test procedures.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20090011521 - Streptavidin surface acoustic wave immunosensor apparatus: The invention, the manufacturing process and operation method for forming the streptavidin surface acoustic wave (SAW) immunosensor apparatus is disclosed. Firstly, the PZT film is formed on silicon substrate by using the micro-powder-sol-gel method. Then, the metal transducer electrodes are coated on the PZT film using semiconductor process technology to... Agent: Bacon & Thomas, PLLC

20090004746 - Microfluidic device with multiple cognitive agents immobilized thereon and methods for its fabrication and method of use: A microfluidic device allowing for multiple discrete reactions sites and allowing for sequential reactions and sample analysis along with methods for device fabrication and use is provided. The microfluidic device provides a micro-total analysis system on a single substrate and has multiple reaction sites allowing for cascade reactions and analysis... Agent: Dorsey & Whitney LLP Intellectual Property Department

20090004747 - Film sensors for detecting free chlorine: The present invention discloses a thin reagent containing film sensor for detecting and measuring free chlorine in water, where components of the film sensor are a polymeric substrate that contains reactive material, an organic polyhydroxy compound, a reagent that creates an associated polymeric matrix, and an indicator; and a method... Agent: General Electric Company Ge Global Patent Operation

20090004748 - Method and apparatus for analyzing a hydrocarbon mixture using nuclear magnetic resonance measurements: A method and apparatus to determine the fractional amount of at least one constituent of a hydrocarbon mixture, comprising dissolving the hydrocarbon mixture in a substantially hydrogen free solvent to produce a diluted solution, the diluted solution having sufficient solvent to render a NMR property of the diluted solution to... Agent: Schlumberger Oilfield Services

20090004749 - Method and kit for determining the amount of dna binding protein: A kit for determining a quantity of a target DNA binding protein in a liquid sample by using a fluorescence correlation spectroscopy, comprising a first measuring reagent including a fluorescent-labeled nucleic acid probe and a first unlabeled nucleic acid probe, a second measuring reagent including the fluorescent-labeled nucleic acid probe... Agent: Sughrue Mion, PLLC

20090004750 - Method of diagnosing cerebral infarction: A method of diagnosing cerebral infarction comprising the step of measuring the concentration of nick β2 glycoprotein I in a body fluid sample; and a method of diagnosing cerebral infarction comprising the steps of measuring the nicked β2 glycoprotein I concentration (N) and the total β2 glycoprotein I concentration (T)... Agent: Sughrue Mion, PLLC

20090004751 - Dry optical-chemical carbon-dioxide sensor: The present invention relates to a device for determining carbon dioxide in a gaseous or liquid sample, comprising: a polymer matrix and an indicator embedded in the polymer matrix, wherein the indicator comprises a pH-sensitive dye and a lipophilic, metal cation-ionophore complex, and wherein an anion of the pH-sensitive dye... Agent: Roche Diagnostics Operations Inc.

20090004752 - Chemical composition and method for detecting counterfeit paper currency: A composition and method of detecting counterfeit paper currency includes applying a test solution to a paper currency having ink printed thereon. If the paper currency is counterfeit, the test solution causes the ink to release from the paper currency. If the paper currency is genuine, the ink will not... Agent: Neal, Gerber, & Eisenberg

20090004753 - Labeling reagents and methods of their use: c

20090004754 - Multi-well reservoir plate and methods of using same: The present disclosure generally relates to a multi-well reservoir plate and methods of using the same. The multi-well reservoir plate includes a frame portion coupled to a plate portion, where a number of receptacles are formed in the plate portion. The receptacles or wells are sized to receive and support... Agent: Seed Intellectual Property Law Group PLLC

20090004757 - Analyte assay using particulate labels: Method for specific detection of one or more analytes in a sample. The method includes specifically associating any one or more analytes in the sample with a scattered-light detectable particle, illuminating any particle associated with the analytes with light under conditions which produce scattered light from the particle and in... Agent: Buchanan, Ingersoll & Rooney PC

20090004755 - Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes: The present invention relates to methods and compositions for diagnosing SIRS, sepsis, severe sepsis, septic shock, or MODS in a subject, or assigning a prognostic risk for one or more clinical outcomes for a subject suffering from SIRS, sepsis, severe sepsis, septic shock, or MODS, the method comprising performing an... Agent: Inverness Medical Innovations / Wsgr Wilson Sonsini Goodrich & Rosati, P.C.

20090004756 - Methods for identifying agents that target leaks in ryanodine receptors: The present invention provides screening methods for identifying agents that enhance binding of a ryanodine receptor and its corresponding FKBP protein, such agents to be used in treating diseases associated with ryanodine receptors.... Agent: Wilmerhale/columbia University

20090004758 - Resonant magnetic disks for bioanalyte detection: Embodiments of the invention relate generally to ferromagnetic microdisks, methods of detecting target bioanalyte using ferromagnetic microdisks, and kits (such as for using in the laboratory setting) containing the reagents necessary to make, and/or use ferromagnetic microdisks for bioanalyte detection, depending on the user's planned application. The methods and products... Agent: Client 21058 C/o Darby & Darby P.C.