Chemistry: analytical and immunological testing inventions 12/08

20080318322 - Analysis of mycophenolic acid in saliva using liquid chromatography tandem mass spectrometry: A method for mass spectrometric analysis of a saliva sample possibly containing mycophenolic acid or its metabolites mycophenolic acid phenyl glucuronide (MPAG) or mycophenolic acid acyl-glucuronide (Acyl-MPAG), including the steps: (a) providing a saliva sample containing one or more drug or metabolites; (b) deproteinating the sample; (c) separating the one... Agent: Gauthier & Connors, LLP

20080318323 - Apparatus for multiple automatic analysis of biosamples, method for autoanalysis, and reaction cuvette: A biosample multiple autoanalyzer characterized by including: (1) a sample supply unit having a plurality of biosamples; (2) a first measuring unit fitted with a first optical measuring means capable of detachably holding, in a mutually independent fashion, a plurality of reaction cuvettes independent from each other; (3) a sample... Agent: Heslin Rothenberg Farley & Mesiti PC

20080318324 - Biochip for high-throughput screening of circulating tumor cells: Embodiments in accordance with the present invention relate to the use of effusive filtration to segregate tumor cells from a sample of bodily fluid. In one embodiment, fluid containing a cell is flowed down a channel having a filtration medium present along at least one side wall. The tumor cell... Agent: Townsend And Townsend And Crew, LLP

20080318325 - Method for the analysis of liposomes: A method for the determination of the morphological integrity of a membrane of lipid vesicles, such as liposomes, using electron spin resonance (ESR) spectroscopy including the steps of: a) labeling the lipid vesicles with an ESR-active probe; b) producing a sample by introducing a quantity of the labeled lipid vesicles... Agent: Michael L. Dunn

20080318326 - Method of manufacture: The invention relates to methods of preparing a bilayer lipid membrane on a support matrix as well as a matrix preloaded with a protein and methods to achieve same. Steps used include hydration, pore infiltration, application of bilayer lipid membrane forming solutions and application of protein containing solutions. The methods... Agent: Sughrue Mion, PLLC

20080318327 - Kit and method for mass labelling: The present invention relates to a kit for mass labelling of peptides in two or more samples, comprising a set of mass tagging reagents for reaction at the N-terminals of the peptides and a set of mass balancing reagents for reaction at the C-terminals of the peptides, or vice versa,... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20080318329 - Liquid crystal condensation of nucleic acid (na) complexes: Upon cooling solutions or melts of nucleic acids or other polymers in which the constituent molecules exhibit a varying tendency to form multi-strand complexes and thus liquid crystal phases, the complex-forming oligomers preferentially separate into the liquid crystal phase and condensing into liquid crystal domains. Because the tendency for liquid... Agent: Lathrop & Gage Lc

20080318330 - Method of standardization of bacterial polysaccharides found in rumen fluid: A process of standardizing the strength of dried rumen bacterial polysaccharides is described. These dried rumen bacterial polysaccharides may then be included into a composition with vitamins, probiotics, minerals, an amino acid and/or a monosaccharide and fed to reduce the effect of diarrhea in young animals. The described mixture when... Agent: Robert Terrell Winn

20080318328 - Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products: The invention provides a process for preparing heparin products with a reduced content of glycoserine. A method for detecting glycoserine in preparations of heparin is also provided.... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080318331 - Anthraquinone derivatives as markers for liquids: e

20080318332 - Disease diagnosis by profiling serum glycans: Specific glycomic profiles derived from human blood sera of breast cancer patients and prostate cancer patients were compared to those of disease-free females and males, respectively. The profiles were acquired using MALDI-MS of permethylated N-glycans released from 10-μl sample aliquots. Quantitative permethylation was attained using solid-phase permethylation. Principal component analysis... Agent: Barnes & Thornburg LLP

20080318333 - Method and system for measurement of nitrite and nitric oxide release: A method for combined measurement of release of nitrite (NO2−) and nitric oxide (NO) from a probe containing nitric oxide, such as an intravascular medical device immersed in an aqueous solution within a first vessel, comprises conveying nitric oxide (NO) released directly from the probe to a nitric oxide analysis... Agent: Muncy, Geissler, Olds & Lowe, PLLC

20080318334 - Microfluidic devices comprising fluid flow paths having a monolithic chromatographic material: Aspects of the invention include a microfluidic device having a fluid flow path and a monolithic chromatographic material covalently bound to at least a portion of a polymeric surface of the fluid flow path. Aspects of the invention further include methods of making and using such devices.... Agent: Agilent Technologies Inc.

20080318335 - Transgenic plant for detecting environmental chemicals: The present invention provides a plant transformation vector for producing a plant for detecting an environmental chemical by a change of flower color, the plant transformation vector comprising an AhR gene expressibly incorporated therein, an AhR ligand stimulus-inducible promoter, and an expression suppressive factor for suppressing the expression of a... Agent: Drinker Biddle & Reath (dc)

20080318336 - Labels, their production process and their uses: e

20080318338 - Assays and implements for determining and modulating hsp90 binding activity: Ligand binding assays as applied to HSP90s as receptors or ligands, and reagents useful therefore, are described and claimed, as are methods of assaying for HSP90 modulators and methods of using the resulting products identified thereby.... Agent: Biogen Idec / Finnegan Henderson, LLP

20080318337 - Method for determining a tissue degradation process by detection of comp neoepitopes: The present invention relates to a method for determining a tissue degradation process by detection on COMP (Cartilage Oligomeric Matrix Protein) neoepitopes, where said COMP neoepitopes appear after cleavage of COMP at one or more site between position 530 and 660 of the amino acid sequence of COMP. Such as... Agent: Wolf Greenfield & Sacks, P.C.

20080318339 - Sensing device and method for determination of teh amount of target molecule in an analyte: A sensing device is provided which has a universal sensor surface. This allows easy modification of the detection properties without the need for investigation of the binding properties of a new target to the sensor surface. The device comprises a sensor surface, which has attached thereto a primary capture molecule.... Agent: Philips Intellectual Property & Standards

20080318341 - Dual path immunoassay device: The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test site with immobilized antigens or antibodies or other... Agent: Gordon & Jacobson, P.C.

20080318340 - Method of detecting target substances: The present invention provides a method for identifying and detecting multiple types of target substances contained in a specimen, comprising the steps of: contacting the target substances immobilized and/or nonimmobilized on a support with labeled binders capable of identifying corresponding types of target substances so as to form complexes between... Agent: Birch Stewart Kolasch & Birch

20080318342 - Diagnostic testing process and apparatus incorporating controlled sample flow: An apparatus (10) and method for use in a vertical flow-through assay process is characterised by applying pressure to a sample to force the sample through a reaction/capture membrane (12), to which one or more ligands are bound, at a controlled rate. Typically, the method includes a pre-incubation step in... Agent: Bozicevic, Field & Francis LLP

20080311662 - Method for analyzing oligomeric proanthocyanidin (opc): The present invention is a novel method for assay of OPC which assays anthocyanidin, obtained by hydrolysis of OPC, to determine the total amount of OPC, and elucidates the proportions of the polymerization degrees of OPC by high performance liquid chromatography (HPLC) to determine the contents of the respective polymers... Agent: Drinker Biddle & Reath (dc)

20080311663 - Gas analyzer apparatus and method of analyzing gases: A gas analyzer apparatus includes a device or platform for supporting a predetermined quantity of a reagent capable of reacting with a predetermined gas to cause a detectable change in a characteristic of the reagent, a reservoir adapted to retain the reagent, a dispenser for dispensing a controlled quantity of... Agent: Honeywell International Inc.

20080311664 - Blancher with automated process control: A method of operating a blanching system includes steps of automatically sampling a blanching solution and mixing the sampled blanching solution with a reagent that is formulated to change at least one property according to a concentration of a metal ion in the blanching solution. This property is automatically sensed... Agent: Knoble, Yoshida & Dunleavy

20080311665 - Chemical assays: An assay device in which to carry out a fluid-phase chemical assay, comprising means for supporting a test substrate, a sample chamber for receiving a fluid sample and at least one fluid control device for controlling the movement of fluid into and/or out of the sample chamber, wherein the fluid... Agent: St. Onge Steward Johnston & Reens, LLC

20080311666 - Isotopically labeled compositions and method: Compounds having stable isotopes 13C and/or 2H were synthesized from precursor compositions having solid phase supports or affinity tags.... Agent: Los Alamos National Security, LLC

20080311667 - Exogenous markers for oxidative stress: The invention provides oxogenous markers, designed and synthesized for the measurement and characterization of oxidative/nitrosative stress levels, thus enable the identification of the type of reactive ROS/NRS involved, characterization of the damaged products and their formation kinetics, and thereby the identification of pathological conditions associated with oxidative/nitrosative stress, before appearing... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080311668 - Nucleic acid detection: Disclosed is the detection of a target nucleic acid sequence in a mixture of different nucleic acids having additional binding sites, by: hybridizing the target nucleic acid sequence with a probe in liquid phase, the probe having a first label. The additional binding sites are hybridized with single stranded nucleic... Agent: Ohlandt, Greeley, Ruggiero & Perle, LLP

20080311669 - Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay: Disclosed herein are methods of screening sequence selectivity of oligonucleotide-binding molecules using a gold nanoparticle based calorimetric assay.... Agent: Marshall, Gerstein & Borun LLP

20080311670 - Hydrogel composition: An electrochemical sensor system comprises an electrochemical sensor and a hydrogel composition. The electrochemical sensor has at least a counter electrode and a working electrode. The hydrogel composition contacts the working electrode. The hydrogel composition comprises a first monomer, a second monomer, a cross-linking agent, and a solvent. The first... Agent: Nixon Peabody LLP

20080311671 - Mass spectrometry method for measuring vitamin b6 in body fluid: Provided are methods of detecting the presence or amount of the active form of vitamin B6, pyridoxal 5′-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.... Agent: Foley & Lardner LLP

20080311672 - Membrane based concentrators: A sample concentrator for concentrating analytes in a solvent-containing liquid sample stream, including concentrator housing having a sample stream flow channel and a gas stream flow channel having an inlet and an outlet, a heater for gas in the gas stream conduit, and a hydrophilic ion exchange or non-ionic membrane... Agent: Morgan, Lewis & Bockius, LLP

20080311673 - Biomarkers for breast cancer: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying breast cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as breast cancer or non-breast cancer. The biomarkers can be detected by SELDI mass spectrometry.... Agent: Edwards Angell Palmer & Dodge LLP

20080311675 - Dyes having ratiometric fluorescence response for detecting metabolites: The presently disclosed subject matter provides thiol-reactive, environmentally sensitive fluorescent dyes, or fluorophores, which have an emission wavelength in the visible spectral region. When conjugated with a binding protein, the fluorophores exhibit a ratiometric response to one or more ligands or target analytes. The presently disclosed fluorophore-binding protein conjugates can... Agent: David W. Highet, Vp & ChiefIPCounsel Becton, Dickinson And Company

20080311676 - Immunoassays exhibiting reduced cross-reactivity with hydrophobic drug analyte metabolites: The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo or in vitro to form cross-reacting metabolites wherein cross-reactivity with such... Agent: Paul D. Yasger Abbott Laboratories

20080311674 - Methods and compositions for analyzing proteins: Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. A mixture comprising the sample and a first reagent comprising a cleavage-inducing moiety and a first binding agent for a binding site on a target... Agent: Monogram/fenwick

20080311678 - Sample analyzer and sample analyzing method: The present invention is to present a sample analyzer which is capable of separate and dispose of the reaction container and the reaction liquid respectively even when magnetic particles are included in a reagent. The sample analyzer 1 comprises: a detector 16 for detecting the target substance by using a... Agent: Sughrue Mion, PLLC

20080311677 - Systems and methods for detecting target analytes: A method of detecting a target substance includes contacting the target substance with a substrate. The substrate has a first receptor bound to the substrate. The target substance binds to the first receptor. The method further includes contacting a second receptor with the substrate. The second receptor is associated with... Agent: Larson Newman Abel Polansky & White, LLP

20080311679 - Biosensor device: The invention relates to a biosensor device with an actuating element comprising a biorecognition element that is capable of binding target molecules from a sample of interest, wherein the actuating element comprises a polymer material, can be actuated by actuating means between a first and a second position.... Agent: Philips Intellectual Property & Standards

20080311680 - Method for detecting high antigen concentration and device therefor: A method for detecting high antigen concentration is disclosed. The method enables the mobile-phase antibody, in the presence of excessive amount of antigen, to form the antibody-antigen-antibody sandwich with the immobilized solid-phase antibody effectively in a rapid lateral flow chromatographic immunoassay. The mobile-phase and/or immobilized solid-phase antibody are treated with... Agent: Sam Chen

20080311681 - Antibody binding affinity ligands: The present application discloses a solid support material having covalently immobilized thereon an affinity ligand, said ligand comprising one or more hydrophobic functional group(s) and one or more cationic functional group(s) or one or more heteroaromatic functional group(s), wherein at least one hydrophobic functional group is separated from at least... Agent: Edwards Angell Palmer & Dodge LLP

20080305548 - Method for stimulating saliva production during oral sample collection procedure: A method and device are provided for stimulating and increasing the production of saliva during immunoassay tests for drugs or other analytes wherein a scent or odor capable of stimulating saliva production is incorporated into a device for obtaining an oral sample from a test subject. The scent or odor... Agent: Stites & Harbison PLLC

20080305549 - Lipoprotein analysis by differential charged-particle mobility: The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by... Agent: Foley & Lardner LLP

20080305550 - Targets for detection of ischemia: The subject application comprises methods for determining the occurrence of an ischemic event in a subject by determining an ischemia score based on the amount of at least two ischemia modified albumin markers. The ischemia modified albumin markers include complexes of fatty acids bound to albumin, albumin molecules with open... Agent: Swanson & Bratschun, L.L.C.

20080305552 - Assays for preimplantation factor and preimplantation factor peptides: The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently... Agent: Pepper Hamilton LLP

20080305551 - Method for diagnosing a pervasive developmental disorder: A method for diagnosing a pervasive developmental disorder, such as autism, comprising obtaining a sample of cerebrospinal fluid from a subject; obtaining a sample of serum from a subject; testing the cerebrospinal fluid of the subject for a concentration of TNF-α; testing the serum of the subject for a concentration... Agent: Cahn & Samuels LLP

20080305553 - Kinetic determination of peracid and/or peroxide concentrations: A use composition monitor determines the concentration of peracid and/or peroxide in a use composition using a kinetic assay procedure. A sample mixture containing a sample of the use composition, a diluent and at least one reagent is prepared and analyzed using, for example, an optical detector. Response data obtained... Agent: Shumaker & Sieffert, P. A.

20080305554 - Automated yield monitoring and control: A system is adapted to automatically maintain a desired yield level for a slurry flow. Measurements of the electrical conductivity of a slurry are taken and corrected for the effects of temperature and pressure. The corrected conductivity measurements are used to arrive at a value for system yield. The system... Agent: Woodcock Washburn LLP

20080305555 - Methods, compositions and devices for performing ionization desorption on silicon derivatives: A device for the presentation of samples for MALDI or DIOS ion source, comprising a semiconductor wafer body having at least one first surface and at least one second surface, the first surface being chemically modified to repel said aqueous sample toward said second surface.... Agent: Waters Investments Limited C/o Waters Corporation

20080305556 - Chemical reaction cartridge and method of using the same: The invention provides a chemical reaction cartridge which can be treated with safety upon introduction of a sample into the cartridge and a method of using the same. An opening section of the chemical reaction cartridge is openable and closable by a rail fastener provided inside an elastic body. When... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20080305557 - Novel applications of acridinium compounds and derivatives in homogeneous assays: Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating functional groups at the C2 and/or C7 position on the acridinium nucleus to inhibit pseudo-base... Agent: Siemens Corporation Intellectual Property Department

20080305558 - Cancer screening test: The invention provides a cancer screening test, to identify patients having an increased likelihood of cancer, comprising the step of determining the presence or absence of members of a test group of tumour associated antigens in the blood of a patient. The test group comprises a plurality of tumour-associated antigens.... Agent: Renner Otto Boisselle & Sklar, LLP

20080305559 - Non-competitive immunoassays to detect small molecules: The present invention provides noncompetitive immunoassays to detect small molecules.... Agent: Townsend And Townsend And Crew, LLP

20080299663 - Validation plate for fluorescence polarization microplate readers: A polarization validation microplate for validating fluorescence polarization readers includes a microplate housing and one or more sealed fluorescence polarization samples in the housing positioned for reading by a fluorescence polarization reader.... Agent: Myers Bigel Sibley & Sajovec

20080299664 - Reagent for lead assay: A reagent for lead assay whereby a lead concentration can be accurately assayed even if an analyte contains calcium ions, and a method for assaying the lead concentration using the reagent for lead assay are provided. The reagent for lead assay contains a porphyrin nucleus-incorporated polymer, which is obtained by... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080299665 - Method for determination of polymer concentration in water systems: In one aspect, the invention is directed to a method for determining the concentration of anionic polymers or oligomers in industrial water comprising combining a buffer solution and a cationic dye solution, measuring absorbance of the buffer-dye admixture at selected wavelength(s) and determining the polymer or oligomer concentration from the... Agent: General Electric Company Ge Global Patent Operation

20080299666 - Novel peptide-based borono-lectin (pbl) sensors: Peptide-based borono-lectin sensors, along with their synthesis and analysis and methods of use, are generally described. These sensors use peptides as a scaffold and introduce boronic acid moieties onto the peptide scaffold as the binding site for the targeted analyte (e.g., carbohydrates, glycans, etc.). The boronic acid moieties can be... Agent: Dority & Manning, P.A.

20080299668 - Detection and quantitation of calicheamicin: The present invention provides a method of detecting the presence of the calicheamicin component of a calicheamicin-carrier conjugate in a fluid sample, wherein the calicheamicin is covalently bound to the carrier. A bond between the calicheamicin and carrier is disrupted, the calicheamicin portion is released from the calicheamicin-carrier conjugate and... Agent: Wyeth Patent Law Group

20080299667 - Optical reporter compositions: This invention provides compositions that have a light emitting reporter linked to biomolecules, preferably, nucleotide oligomers. The light reporter particles are silylated and functionalized to produce a coated light reporter particle, prior to covalently linking the biomolecules to the light reporter particle. The light reporter particles of the invention can... Agent: Virtual Legal, P.C. Michael A. Kerr

20080299669 - Methods and devices for analytical sensing of biogenic amines: Disclosed herein are chromogenic response polymers and methods and devices that utilize the disclosed polymers which are suitable for use in detecting the presence of and identity of biogenic amines.... Agent: Ballard Spahr Andrews & Ingersoll, LLP

20080299670 - Combustion tube and method for combusting a sample for combustion analysis: Combustion tube (100,130,150) and method for combusting a sample to form combustion products for analysis. A primary combustion chamber (102) receives and combusts a sample to form first combustion products. A secondary combustion chamber (110) receives and combusts the first combustion products to form second combustion products. The secondary chamber... Agent: Haynes And Boone, LLP

20080299671 - Hydrophobic interaction chromatography: The present invention relates to a method of isolating target compounds from a liquid, which method including the steps of providing a mobile phase, which contains at least one target compound and wherein the conductivity corresponds to ≧0.6 M; contacting the mobile phase with a separation matrix including one or... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20080299672 - System and method for testing chromatography media and devices: Methods for testing the chromatography type and/or the integrity of a chromatography membrane or monolith, preferably, for testing the chromatography type and integrity of a chromatography device comprising a chromatography membrane or chromatography monolith while the membrane or monolith is sealed in a housing, are disclosed.... Agent: Leydig Voit & Mayer, Ltd

20080299673 - Method for employing a biosensor to detect small molecules (\"fragments\") that bind directly to immobilized protein targets: The invention provides method of detecting interactions of small molecules with target molecules.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080299675 - Luminescent lanthanide binding chelates: Lanthanide chelates derived from diazacrown ethers having two ethyliminodiacetic acid side chains have increased ability to bind lanthanide ions.... Agent: Richard Aron Osman

20080299674 - Novel isonitrile compound, its method of manufacture, a marine fouling organism larva fluorescent, and a method of detecting this marine fouling organism larva using said marker: n

20080299676 - Methods for diagnosing endometriosis: Provided herein is a method for diagnosing and monitoring endometriosis in a subject by measuring levels of the 13-subunit of fibrinogen.... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080299677 - New assays for preimplantation factor and preimplantation factor peptides: The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently... Agent: Pepper Hamilton LLP

20080299678 - Methods for characterizing glycosylation sites: The present invention provides methods for isolating and characterizing the glycosylation sites of a glycoprotein, such as a glycosylated antibody. In particular, the methods employ affinity capture, liquid chromatography, and mass spectrometry to determine, for example, the location of the glycopeptide, the heterogeneity of the glycan attached to the glycopeptide,... Agent: Lahive & Cockfield, LLP/medarex Floor 30, Suite 3000