Chemistry: analytical and immunological testing inventions 11/08

20080293144 - Five-part differential white blood cell control and method for preparation of the same: The present invention provides a method for preparing a five-part differential white blood cell control and a white blood cell control prepared thereby. The white blood cell control obtained by the method of the present invention perfectly retains the light scattering properties of every type of white blood cells and... Agent: Mindray C/o VistaIPLaw Group LLP

20080293145 - Single population of simulated leukocyte granules, calibrators comprising the same and methods of preparing the same: The present invention discloses a single population of simulated leukocyte granules prepared from mammalian whole white blood cells, which is useful in calibrators for a hematology analyzer, a calibrator comprising the single population of simulated leukocyte granules, and a method of preparing the single population of simulated leukocyte granules. The... Agent: Mindray C/o VistaIPLaw Group LLP

20080293146 - Method and apparatus for compensating for variations in particle trajectories in electrostatic sorter for flowcell cytometer: A flow cytometer subsystems monitors a particle sensing zone within a fluid transport chamber for the presence of a particle (e.g., blood cell) traveling therethrough, and produces an output pulse, whose width is representative of the trajectory and thereby the length of time that the particle is within the particle... Agent: Beckman Coulter, Inc.

20080293147 - Method of detecting structural change in target sugar chain: A method of easily and efficiently detecting any structural change in a target sugar chain that can be present as a first or a second sugar chain depending on the structural change. In the method, the target sugar chain is mixed with a first to an nth lectin that can... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080293149 - Assays for preimplantation factor and preimplantation factor peptides: The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently... Agent: Pepper Hamilton LLP

20080293148 - Method and system for detecting bio-element: Disclosed are system and method for measuring a bio-element capable of accurately detecting whether a bio-element such as protein, gene and the like is present in an atmosphere or vapor phase having controlled temperature and humidity thereof and measuring a content of the bio-element. According to an embodiment of the... Agent: Fenwick & West LLP

20080293150 - Nmr signal assignment method: It is an object of the present invention to provide a method of efficiently and rapidly determining the assignment of signals obtained by the 1H-15N HSQC measurement or the like, and a method of efficiently and rapidly identifying the three-dimensional structure of a target protein using the above method or... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080293151 - Fiber-packed needle for analyzing aldehydes/ketones, analytical apparatus and analytical method: Provided are a simple method for analyzing aldehydes and ketones in a sample, which does not require a complicated operation such as extraction with a solvent and concentration of the extract; and an analytical apparatus and a fiber-packed needle which are used in the analytical method. Also provided a fiber... Agent: Nixon & Vanderhye, PC

20080293152 - Nanomembranes for remote sensing: The present invention provides sensors for use in detecting the presence or absence of analytes, systems incorporating the sensors, and methods for using the sensors. The sensors include thin membranes that undergo a detectable geometry change upon exposure to an analyte. In one exemplary embodiment, the sensors are small, thin-film... Agent: Wisconsin Alumni Research Foundation (warf)

20080293153 - Photolabile system with instantaneous fluorescence reporting function: A method of photofragmentation is provided comprising: providing a masked fluorescent molecule having a masking group bonded to a fluorescent molecule through a photolabile covalent bond; exposing the masked fluorescent molecule to cleaving photoradiation, producing an unmasked fluorescent molecule; detecting the fluorescence of the unmasked fluorescent molecule. The photolabile covalent... Agent: Greenlee Winner And Sullivan P C

20080293154 - Apparatus and method for detecting target: The target detecting apparatus includes: a first container having a metal inside and containing a fluorescent particle which generates fluorescence on exposure to light and quenches the fluorescence on contacting the metal; a second container having the metal inside and containing a target sample that contains at least the fluorescent... Agent: Kratz, Quintos & Hanson, LLP

20080293155 - Salicylamide-lanthanide complexes for use as luminescent markers: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one salicylamidyl moiety. Also provided are probes incorporating the salicylamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands... Agent: Jeffry S. Mann Townsend And Townsend And Crew LLP

20080293157 - Apparatus and method of performing high-throughput cell-culture studies on biomaterials: In one embodiment, a kit includes a base and a specimen removably couplable to the base. A top plate defines a plurality of apertures and is removably couplable to the base such that at least two of the apertures are associated with a specimen and each aperture defines a well... Agent: Crompton, Seager & Tufte, LLC

20080293156 - Devices and methods for dispensing reagents into samples: Devices and methods of dispensing and mixing reagents with samples in an enclosed container in which the amounts of the reagents dispensed into the sample are predetermined. The devices include dispensing covers attached to a funnel that feeds into a sample chamber. The dispensing covers may contain off-axis dispensing chambers... Agent: 3m Innovative Properties Company

20080293158 - Method and apparatus for improved gas detection: The invention relates to a method and apparatus for providing a reactor having a heater, a passage for transporting a reactant, and a chamber containing a gas sample and being coupled to the passage for receiving the reactant and mixing the reactant with the gas sample. The reactor further includes... Agent: St. Onge Steward Johnston & Reens, LLC

20080293161 - Detection of carbohydrate biomarkers: The present invention generally relates to detection of carbohydrate biomarkers in nipple aspirate fluid samples. One aspect of the invention is a method for assaying a nipple aspirate fluid for the presence of TF or Tn carbohydrate biomarker. The assay generally employs an immobilized capture agent specific for TF or... Agent: Senniger Powers LLP

20080293160 - Dna and rna conformational switches as sensitive electronic sensors of analytes: The electrical conductivity of DNA and other oligonucleotide constructs is dependent on its conformational state. Such a dependence may be harnessed for the electronic sensing of external analytes, for instance, adenosine or thrombin. Such a DNA sensor incorporates an analyte receptor, whose altered conformation in the presence of bound analyte... Agent: Oyen, Wiggs, Green & Mutala LLP 480 - The Station

20080293162 - Methods and compositions for diagnosing neoplastic disease: Methods and compositions for determining whether a subject at least has a neoplastic disease are provided. In practicing the subject methods, a sample from a subject is assayed for a soluble filamin analyte, such as a filamin A analyte, to determine whether the subject at least has the neoplastic disease.... Agent: Invitrogen Corporation C/o Intellevate

20080293159 - Validation process: The present invention provides a process for validating the efficacy of a sample having a known activity determined using a biological assay. The process includes subjecting the sample to a biological assay capable of testing for the activity. The process may optionally include an initial step of determining a biological... Agent: Myers Bigel Sibley & Sajovec

20080293163 - Methods to identify compounds that modulate rage: Provided are methods to detect of modulators of the Receptor for Advanced Glycated Endproducts (RAGE). The invention comprises a method for detection of RAGE modulators comprising: adsorbing a RAGE ligand onto a solid surface; adding a compound of interest and a protein comprising RAGE or fragment thereof, to the preadsorbed... Agent: Kilpatrick Stockton LLP - 41305 Charles Calkins

20080293164 - Fluorescent methods and materials for directed biomarker signal amplification: Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore... Agent: Wilson Sonsini Goodrich & Rosati

20080286872 - Automatic analyzer: An automatic analyzer analyzes a measurement item by making a sample and reagent react with each other and measuring the reaction result. This apparatus allows parameters associated with reagent dispensing executed by a reagent dispensing mechanism to be set as a dispensing condition for each measurement item or each type... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080286873 - Method and device for reducing positron emitting isotope labeled carbon dioxide to positron emitter isotope labeled carbon monoxide via metal oxide: A method and device for reducing positron emitter isotope labeled CO2 to positron emitter isotope labeled CO generally includes introducing a volume of positron emitter isotope labeled CO2 into a first heated reaction vessel comprising a metal oxide, such as Iron (II) Oxide such that the CO2 is reduced to... Agent: Siemens Corporation Intellectual Property Department

20080286874 - Reducing or avoiding muscle cramps: Muscle cramps can be reduced or avoided by monitoring the concentration of salt in perspiration to indicate the degree of salt depletion. Based on the degree of salt depletion, a sufficient amount of rehydration beverage is consumed to normalize the salt level.... Agent: Banner & Witcoff, Ltd. And Attorneys For Client No. 006943

20080286877 - Displacement assay for detection of small molecules: Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a calorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2-5000 μM. Mechanistic studies indicate an intermolecular displacement of the dye as the mechanism of action of the sensor. As the dye... Agent: John P. White Cooper & Dunham LLP

20080286876 - Genes associated with alzheimer's disease - hltdip: A method of screening a small molecule compound for use in treating Alzheimers Disease, comprising screening a test compound against a target or targets selected from the gene products encoded by a group of specified genes, where activity against said target indicates the test compound has potential use in treating... Agent: Glaxosmithkline Corporate Intellectual Property

20080286875 - Ryr2 mutations: This document provides methods and materials related to assessing a mammal for the presence or absence of a genetic mutation. For example, methods for determining whether or not a mammal contains a genetic mutation in an RyR2 sequence are provided. In addition, isolated nucleic acid molecules containing an RyR2 sequence... Agent: Fish & Richardson P.C.

20080286878 - Systems, compositions and methods for nucleic acid detection: The invention relates to stretch measurements of nucleic acids and correlating those measurements to the extent of double- and single-stranded content of a nucleic acid of interest, and to compositions, systems, and devices related thereto. In preferred embodiments, one performs the stretch or elasticity measurements under conditions such that one... Agent: Medlen & Carroll, LLP

20080286879 - Test device, and related methods: Test device for detection and visual indication of a specific analyte in a liquid sample such as a body fluid. The device includes a biodegradable housing, a test strip and a lid. The device is configured for placement in concentrate or dilute test liquid that is for example contained in... Agent: Lathrop & Gage Lc

20080286880 - Methods and systems for nanoparticle enhancement of signals: Methods and systems for utilizing metal nanoparticles to enhance optical (UV, visible, and IR, as appropriate) signals from a reporting entity are presented. The methods and systems of this invention do not require the nanoparticles to be attached or adhered to a surface, assembled in a matrix or coated with... Agent: Burns & Levinson, LLP

20080286881 - Compositions and methods for combining report antibodies: Compositions are disclosed. One embodiment of a composition comprises a first antibody having an affinity for an antigen and a second antibody having an affinity for the first antibody, wherein at least one antibody is conjugated to a marker, and wherein the antigen is not present in the composition. Further... Agent: Battelle Energy Alliance, LLC

20080286882 - Method and apparatus for measuring the concentration of a ligand contained in a sample that is to be tested: In a method for measuring the concentration of a ligand contained in a sample that is to be tested, at a plurality of test sites that are located on the surface of at least one substrate, in each case at least one receptor that is suitable upon contact with the... Agent: The Webb Law Firm, P.C.

20080280364 - Control of apoptosis by controlling the propensity of ceramide channel formation: The present invention relates to a novel target to control the apoptotic process, and to the use of this target to identify compounds capable of affecting the apoptotic process, The invention also relates to the use of such identified compounds in the treatment of cancer, stroke, neurodegenerative diseases, viral diseases... Agent: Edell, Shapiro & Finnan, LLC

20080280365 - Apparatus and method for determining the volume fractions of the phases in a suspension: An apparatus for determining the volume fractions of the phases in a suspension includes a body, a channel structure, which is formed in the body, and an inlet area and a blind channel, which is fluidically connected to and capable of being filled via the same. Furthermore, a drive for... Agent: Schoppe, Zimmerman , Stockeller & Zinkler C/o Keating & Bennett , LLP

20080280366 - Quantitative detection of lead in water: The present invention provides compositions and methods for extracting, isolating, and measuring lead dissolved in aqueous solutions, including water.... Agent: University Of Virginia Patent Foundation

20080280367 - Modulators of nod2 signalling: The present invention relates to intracellular signaling molecules, in particular the Nod2 protein and nucleic acids encoding the Nod2 protein. The present invention provides methods of identifying modulators of Nod2 signaling. In particular, the present invention additionally provides methods of screening immune modulators such as adjuvants using Nod2. The present... Agent: Casimir Jones, S.c.

20080280368 - Parasitic helminth cuticlin proteins and uses thereof: The present invention relates to: parasitic helminth cuticlin proteins; parasitic helminth cuticlin nucleic acid molecules, including those that encode such cuticlin proteins; antibodies raised against such cuticlin proteins; and compounds that inhibit parasitic helminth cuticlin activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies,... Agent: Heska Corporation Legal Department

20080280369 - Compositions for detection and analysis of polynucleotides using light harvesting multichromophores: Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PNA complementary to the target polynucleotide. The sensor PNA comprises a signaling chromophore to absorb energy from... Agent: Bio Technology Law Group C/o Portfolioip

20080280370 - Methods and compositions for detecting glyphosate and metabolites thereof: The present invention provides various methods and compositions which allow for determining the presence or amount of glyphosate, N-acetylglyphosate, N-acetyl AMPA or aminomethyl phosphoric acid (AMPA) and its various metabolites in a variety of test matrices. In one method, determining the presence or amount of N-acetylglyphosate and/or N-acetyl AMPA in... Agent: Alston & Bird LLP Pioneer Hi-bred International, Inc.

20080280371 - Acoustic resonance based urea quality sensor: A urea quality sensor includes an acoustic resonator in order to measure the accurate concentration of urea by measuring change in molecular weight. A change in molecular weight of urea proportionately affects the speed of sound. The change in the composition of the urea solution manifests itself as a change... Agent: Bryan Anderson Honeywell International Inc.

20080280372 - Continuous monitor for cyanide and cyanogen blood agent detection in water: A device for continuous detection of the presence of a cyanide analyte and/or cyanogen analyte in an aqueous sample which relies upon continuous sampling and controlled delivery of reagents for a chemical reaction which forms a colored dye in the presence of the analyte(s). The device employs a single chemical... Agent: Craig G. Cochenour, Esq. Buchanan Ingersoll & Rooney PC

20080280373 - Method and apparatus for measuring ph of low alkalinity solutions: Systems and methods are described for measuring pH of low alkalinity samples. The present invention provides a sensor array comprising a plurality of pH indicators, each indicator having a different indicator concentration. A calibration function is generated by applying the sensor array to a sample solution having a known pH... Agent: Wegman, Hessler & Vanderburg

20080280374 - Methods and systems for detecting biological and chemical materials on a submicron structured substrate: Methods and systems for detecting biological or biochemical analytes generally comprising, a metal film having one or more surfaces comprising one or more submicron structures; a device for applying one or more analytes to at least a portion of the film surface to interact with said metal film; a light... Agent: General Electric Company Global Research

20080280375 - Arsenic-specific stain for identifying arsenic-treated wood: A novel reagent is used to identify arsenic-treated wood. The stain may detect arsenic extracted from wood into solution; arsenic transferred from wood to a wipe, which is then extracted into solution; or the stain may be directly applied at a predetermined location on the wood's surface. Copper preservatives are... Agent: Nixon & Vanderhye, PC

20080280377 - Human b-type natriuretic peptide assay having reduced cross-reactivity with other peptide forms: The present disclosure provides among other things assays, methods and kits for assessing the presence or amount of human B-type natriuretic peptide in a test sample wherein the assay exhibits reduced cross-reactivity with other forms of the peptide.... Agent: Paul D. Yasger Abbott Laboratories

20080280376 - Method of evaluation of the relative risk of developing atherosclerosis in patients: The present invention relates to a method for determining the amount of circulating CD36 protein or a fraction thereof which is present in cell-free plasma, preferably in a high molecular weight plasma fraction, such as a lipoprotein fraction selected from Low Density Lipoprotein, Intermediate Density Lipoprotein, and Very Low Density... Agent: Browdy And Neimark, P.l.l.c. 624 Ninth Street, Nw

20080280378 - Grading of immune responses: The invention is a method for grading a polyclonal antibody response with respect to a desired 5 binding specificity. The response is provoked by an antigenic agent in a host, preferably a vertebrate host. The characteristic feature of the method comprises the steps of: (i) providing a reaction microcavity having... Agent: Fulbright & Jaworski L.l.p

20080274551 - Reagent, system and method for nitrate analysis: A reagent and colorimetric autoanalyzer are provided for determining nitrate concentration using an EPA approved method. Methods of determining nitrate concentration using a reagent and a calorimetric autoanalyzer are also provided. The device and use thereof allows for the automated and accurate determination of nitrate in a sample, resulting in... Agent: Ryndak & Suri LLP

20080274552 - Dynamic information transfer: Disclosed are various preferred embodiments for dynamic transfer of information from a test sensor to an analyte medical test device. Exemplary embodiments include various containers, systems and methods.... Agent: Philip S. Johnson Johnson & Johnson

20080274553 - Method to detect and characterize contaminants in pipes and ducts with interactive tracers: A method and an apparatus for detecting, locating, and quantifying contamination in a fluid flow system like a pipe or duct. This characterization technique uses a conservative and one or more interactive tracers that are injected into the fluid flow system and then monitored at another location in the system.... Agent: Pillsbury Winthrop Shaw Pittman LLP

20080274554 - Oximeter for spectro-photometric in-vitro determination of hemoglobin derivatives: An oximeter for spectro-photometric in-vitro determination of hemoglobin derivatives in a sample, typically a hemolyzed blood sample, is provided comprising a single measurement light source emitting measurement radiation, a sample chamber, for instance a measurement cuvette containing the sample, a detector device, which records a spectrum of the measurement radiation... Agent: Roche Diagnostics Operations Inc.

20080274555 - Separation and manipulation of a chiral object: Among other things, for use in directional motion of chiral objects in a mixture, a field is applied across the chamber and is rotating relative to the chamber to cause rotation of the chiral objects. The rotation of the objects causes them to move directionally based on their chirality. The... Agent: Fish & Richardson PC

20080274556 - Detecting isomers using differential derivatization mass spectrometry: Methods of evaluating molecular isomers of branched-chain amino acids are featured. The methods can include: derivatizing one or more molecular isomers of branched-chain amino acids in a sample comprising a branched-chain amino acid labeled with one or more heavy atoms as a first standard; adding, to the sample, after derivatization,... Agent: Fish & Richardson PC

20080274558 - Method for identifying and selecting low copy nucleic segments: The present invention relates to a method of identifying low copy nucleic acid segments from within a known nucleic acid sequence and selecting among the identified low copy segments for segments that are thermodynamically suitable for use in hybridization experiments.... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080274557 - Permethylation of oligosaccharides: A solid-phase permethylation procedure is described. For example, solid-phase permethylation can be utilized to prepare permethylated linear and branched, neutral and sialylated oligosaccharides, which can be analyzed by MALDI-MS.... Agent: Barnes & Thornburg LLP

20080274559 - Gas sensor for determining ammonia: The invention relates to a gas sensor which is used to detect ammonia by detecting and evaluating conductivity variations on semi-conductive metal oxides, comprising: a substrate, a gas sensitive layer made of a semi-conductive metal oxide, a catalytic filter which is disposed in front of the metal oxide, said filter... Agent: Cohen, Pontani, Lieberman & Pavane LLP

20080274560 - Reagents for detection of hypochlorous acid: Provided herein are compounds or hypochlorous acid probes which can be used as reagents for measuring, detecting and/or screening, directly or indirectly, hypochlorous acid or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of hypochlorous acid or hypochlorite in chemical samples... Agent: Jones Day

20080274561 - Method and apparatus for determining a total concentration of a component in a mixture of components: The invention relates to a method and apparatus for determining a total concentration of a component in a sample, including a reactor for oxidizing or reducing the sample, a chromatographic column coupled to the reactor for separating the component in the sample, and an electrochemical gas sensor coupled to the... Agent: St. Onge Steward Johnston & Reens, LLC

20080274562 - Method of freezing with brine: Improved brine solutions and uses thereof for uncontaminatedly and/or efficiently freezing items such as foods, and biological samples. In accordance with one embodiment, a brine solution containing a sufficient amount of dye in conferring the solution a distinctive color is used in the freezing process. In accordance with another embodiment,... Agent: Edward M. Weisz, Esq. Cohen, Pontani, Lieberman & Pavane

20080274563 - Detecting succinylacetone: This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry.... Agent: Fish & Richardson PC

20080274564 - Pregnancy and sex identification test based on saliva or other bodily fluids: A method of testing an animal for pregnancy or identifying the sex of the animal comprising the steps of first, providing a first vessel containing a liquid and having a removable surface wherein said removable surface is at least partially coated with an antibody and then introducing a bodily fluid... Agent: Sand & Sebolt

20080274566 - Method and assay for detection of residues: Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some... Agent: Charm Sciences, Inc.

20080274565 - Method for the quantitative measurement of analytes in a liquid sample by immunochromatography: b