Chemistry: analytical and immunological testing inventions 10/08

20080261312 - Methods for matrix cleanup and analysis of drugs and metabolites in biological matrices: The invention is directed to the use of weak anion exchange (WAX) materials for trapping of negative and zwitterionic interferences from biological matrices, and then reduction of the biological matrix effect in the quantitative analysis process of basic and neutral compounds present in the matrix. The sample preparation process includes... Agent: Yuhui Yang

20080261313 - Apo b measurement system and method: A system and method for measuring apolipoprotein B100 (apo B) during the cholesterol subclass measurement process is provided which obviates the need for a separate apo B test.... Agent: Dla Piper US LLP

20080261314 - Fluorescent probe for zinc: wherein X1 to X4 represent hydrogen atom, an alkyl group, or 2-pyridylmethyl group, and m and n represent 0 or 1; Y represents a single bond or —CO—; R3 represents a carboxy-substituted aryl group, a carboxy-substituted heteroaryl group, benzothiazol-2-yl group, or 5-oxo-2-thioxo-4-imidazolyzinylidenmethyl group], and a fluorescent probe for zinc which... Agent: Greenblum & Bernstein, P.L.C

20080261315 - Colorimetric and fluorometric determination of homocysteine and cysteine: Colorimetric and fluorometric methods are disclosed for the rapid, accurate, selective, and inexpensive detection of homocysteine, or of homocysteine and cysteine, or of cysteine. The methods may be employed with materials that are readily available commercially. The novel methods are selective for homocysteine, for cysteine, or for total homocysteine and... Agent: Patent Department Taylor, Porter, Brooks & Phillips, L.l.p

20080261316 - Compositions and methods for enhancing the identification of prior protein prpsc: A method for purifying PrPc, a purified preparation of PrPc and methods and kits for identifying the presence of PrPc are provided.... Agent: Licata & Tyrrell P.C.

20080261317 - Methods of detecting myocardial ischemia and myocardial infarction: The disclosed methods address the identification of myocardial ischemia and myocardial infarction using metabolomics, as well as the identification of metabolic products whose differential expression over time is indicative of myocardial ischemia and/or myocardial infarction.... Agent: Ewards Angell Palmer & Dodge LLP

20080261318 - Signalling compounds for use in methods of detecting hydrogen peroxide: is reacted with peroxide. Sig is a non-polymeric organic group, B is a boron atom, and each R is independently selected from hydrogen, alkyl and aryl groups and can be joined together as a straight or branched alkylene chain forming a ring or as an aromatic ring. A detectable product... Agent: Lumigen, Inc.

20080261319 - Method for detecting presence of aristolochia materials in herbal products and botanicals: A method for detecting herbs or plants of the Aristolochia genus in herbal products and botanicals may be based on the sequence information in the trnL-trnF region and/or the psbA-trnH region. The trnL-trnF region and/or the psbA-trnH of the chloroplast DNA contain a number of segments which are highly characteristic... Agent: Evan Law Group LLC

20080261320 - Noninvasive blood sugar level measuring method: A noninvasive blood sugar level measurement method includes a process of changing a blood sugar level of a biological body, a process of noninvasively measuring biological feature amounts at plural measurement points that are timewise shifted from each other, a process of invasively measuring blood sugar levels of the biological... Agent: Wenderoth, Lind & Ponack L.L.P.

20080261321 - Methods and compositions for detecting and isolating phosphorylated molecules using hydrated metal oxides: The invention provides methods for detecting and isolating phosphomolecules using phosphoaffinity materials that comprise a hydrated metal oxide. In an embodiment, a method for detecting a phosphomolecule in a sample involves (a) contacting a sample with a phosphoaffinity material comprising a hydrated metal oxide, under conditions wherein a phosphomolecule is... Agent: Fish & Richardson PC

20080261322 - Nitric oxide detection: The present invention relates to a method for amplifying the detected signal in a gas sensor. More specifically, the present invention relates to a method for increasing the concentration of the gas which is being detected in a sample or increasing the concentration of a gas which is directly obtained... Agent: Philips Intellectual Property & Standards

20080261323 - Photo-swichable surfaces with controllable physico-chemical properties: Photochromic materials, such as spiropyran dyes, are disclosed that can be used for high-density optical storage and molecular switches. According to the disclosure these compounds can be used as transducers in optical sensors. When the spiropyran dye absorbs UV light it switches to the merocyanine form, and this structure has... Agent: Brown Rudnick LLP

20080261324 - System, device and method for reducing luminescence output shifts: Devices, systems, and methods for conducting chemiluminescent immunoassay testing and, more particularly, to initiating and monitoring a chemiluminescent reaction in a plurality of such assays, of different types, on a single immunoassay instrument, in a single procedure, using a plurality of labels and a triggering reagent combination are disclosed. Moreover,... Agent: Siemens Corporation Intellectual Property Department

20080261326 - Drop-on-demand manufacturing of diagnostic test strips: A drop-on-demand system for manufacturing diagnostic test strips includes a drop-on-demand mechanism, and a drop volume feedback subsystem and/or a vision subsystem. The drop-on-demand mechanism dispenses one or more reagents on the diagnostic test strips in one or more desired volumes and at one or more desired locations. The drop... Agent: Hewlett Packard Company

20080261325 - Method and device for dispensing dry powders: The inventive method for dispersing a dry powder sample (5) in a dispersion chamber (11) consists in vacuuming said chamber (11) with respect to the environment (13), in dispersing a dry powder (5) in the chamber (11), by means of a suction generated by the rupture of a membrane (4)... Agent: Sughrue Mion, PLLC

20080261327 - Cell free assay for determining a substance of interest and molecular complexes used therefore: The invention involves receptor complexes which include, inter alia, a receptor protein, and a reporter molecule. There is at least one unnatural, or non-naturally occurring amino acid in the receptor molecule. When a ligand interacts with the receptor, the interaction causes the reporter to generate a detectable signal. The complexes... Agent: Invitrogen Corporation C/o Intellevate

20080261328 - Method of preventing precipitation of a reactive substance-bound microparticle, and reagent containing the micro particle: According to the present invention, precipitation of a reactive substance-bound microparticle can be prevented in a dispersion liquid, to make a concentration of the reactive substance-bound microparticle uniform in the dispersion liquid. The present invention provides a method of preventing precipitation of a reactive substance-bound microparticle. The method includes coexisting... Agent: The Webb Law Firm, P.C.

20080261329 - Method of analysis of a mixture of biological and/or chemical components with the use magnetic particles and apparatus for its embodiment: Technical result consists in the increase of signal-to-noise ratio and, hence, increase of the accuracy of measurements, sensitivity enhancement, improvement of the reliability of the data obtained, and, at the same time, lowering analysis costs owing to the reduction of the number of operations needed, time, amount and dimensions of... Agent: Drinker Biddle & Reath (dc)

20080261330 - Apparatus components and methods of using apparatus components to detect the presence of an analyte: Apparatus components including rigid supports suitable for use in an affinity column, affinity columns, and an affinity columns in fluid communication with an analytical column, such as in a high pressure liquid chromatography (HPLC) column, are disclosed. Methods of using the apparatus components to detect the presence of one or... Agent: William D Bunch W R Grace & Co Conn Patent Department Legal

20080261312 - Methods for matrix cleanup and analysis of drugs and metabolites in biological matrices: The invention is directed to the use of weak anion exchange (WAX) materials for trapping of negative and zwitterionic interferences from biological matrices, and then reduction of the biological matrix effect in the quantitative analysis process of basic and neutral compounds present in the matrix. The sample preparation process includes... Agent: Yuhui Yang

20080261313 - Apo b measurement system and method: A system and method for measuring apolipoprotein B100 (apo B) during the cholesterol subclass measurement process is provided which obviates the need for a separate apo B test.... Agent: Dla Piper US LLP

20080261314 - Fluorescent probe for zinc: wherein X1 to X4 represent hydrogen atom, an alkyl group, or 2-pyridylmethyl group, and m and n represent 0 or 1; Y represents a single bond or —CO—; R3 represents a carboxy-substituted aryl group, a carboxy-substituted heteroaryl group, benzothiazol-2-yl group, or 5-oxo-2-thioxo-4-imidazolyzinylidenmethyl group], and a fluorescent probe for zinc which... Agent: Greenblum & Bernstein, P.L.C

20080261315 - Colorimetric and fluorometric determination of homocysteine and cysteine: Colorimetric and fluorometric methods are disclosed for the rapid, accurate, selective, and inexpensive detection of homocysteine, or of homocysteine and cysteine, or of cysteine. The methods may be employed with materials that are readily available commercially. The novel methods are selective for homocysteine, for cysteine, or for total homocysteine and... Agent: Patent Department Taylor, Porter, Brooks & Phillips, L.l.p

20080261316 - Compositions and methods for enhancing the identification of prior protein prpsc: A method for purifying PrPc, a purified preparation of PrPc and methods and kits for identifying the presence of PrPc are provided.... Agent: Licata & Tyrrell P.C.

20080261317 - Methods of detecting myocardial ischemia and myocardial infarction: The disclosed methods address the identification of myocardial ischemia and myocardial infarction using metabolomics, as well as the identification of metabolic products whose differential expression over time is indicative of myocardial ischemia and/or myocardial infarction.... Agent: Ewards Angell Palmer & Dodge LLP

20080261318 - Signalling compounds for use in methods of detecting hydrogen peroxide: is reacted with peroxide. Sig is a non-polymeric organic group, B is a boron atom, and each R is independently selected from hydrogen, alkyl and aryl groups and can be joined together as a straight or branched alkylene chain forming a ring or as an aromatic ring. A detectable product... Agent: Lumigen, Inc.

20080261319 - Method for detecting presence of aristolochia materials in herbal products and botanicals: A method for detecting herbs or plants of the Aristolochia genus in herbal products and botanicals may be based on the sequence information in the trnL-trnF region and/or the psbA-trnH region. The trnL-trnF region and/or the psbA-trnH of the chloroplast DNA contain a number of segments which are highly characteristic... Agent: Evan Law Group LLC

20080261320 - Noninvasive blood sugar level measuring method: A noninvasive blood sugar level measurement method includes a process of changing a blood sugar level of a biological body, a process of noninvasively measuring biological feature amounts at plural measurement points that are timewise shifted from each other, a process of invasively measuring blood sugar levels of the biological... Agent: Wenderoth, Lind & Ponack L.L.P.

20080261321 - Methods and compositions for detecting and isolating phosphorylated molecules using hydrated metal oxides: The invention provides methods for detecting and isolating phosphomolecules using phosphoaffinity materials that comprise a hydrated metal oxide. In an embodiment, a method for detecting a phosphomolecule in a sample involves (a) contacting a sample with a phosphoaffinity material comprising a hydrated metal oxide, under conditions wherein a phosphomolecule is... Agent: Fish & Richardson PC

20080261322 - Nitric oxide detection: The present invention relates to a method for amplifying the detected signal in a gas sensor. More specifically, the present invention relates to a method for increasing the concentration of the gas which is being detected in a sample or increasing the concentration of a gas which is directly obtained... Agent: Philips Intellectual Property & Standards

20080261323 - Photo-swichable surfaces with controllable physico-chemical properties: Photochromic materials, such as spiropyran dyes, are disclosed that can be used for high-density optical storage and molecular switches. According to the disclosure these compounds can be used as transducers in optical sensors. When the spiropyran dye absorbs UV light it switches to the merocyanine form, and this structure has... Agent: Brown Rudnick LLP

20080261324 - System, device and method for reducing luminescence output shifts: Devices, systems, and methods for conducting chemiluminescent immunoassay testing and, more particularly, to initiating and monitoring a chemiluminescent reaction in a plurality of such assays, of different types, on a single immunoassay instrument, in a single procedure, using a plurality of labels and a triggering reagent combination are disclosed. Moreover,... Agent: Siemens Corporation Intellectual Property Department

20080261326 - Drop-on-demand manufacturing of diagnostic test strips: A drop-on-demand system for manufacturing diagnostic test strips includes a drop-on-demand mechanism, and a drop volume feedback subsystem and/or a vision subsystem. The drop-on-demand mechanism dispenses one or more reagents on the diagnostic test strips in one or more desired volumes and at one or more desired locations. The drop... Agent: Hewlett Packard Company

20080261325 - Method and device for dispensing dry powders: The inventive method for dispersing a dry powder sample (5) in a dispersion chamber (11) consists in vacuuming said chamber (11) with respect to the environment (13), in dispersing a dry powder (5) in the chamber (11), by means of a suction generated by the rupture of a membrane (4)... Agent: Sughrue Mion, PLLC

20080261327 - Cell free assay for determining a substance of interest and molecular complexes used therefore: The invention involves receptor complexes which include, inter alia, a receptor protein, and a reporter molecule. There is at least one unnatural, or non-naturally occurring amino acid in the receptor molecule. When a ligand interacts with the receptor, the interaction causes the reporter to generate a detectable signal. The complexes... Agent: Invitrogen Corporation C/o Intellevate

20080261328 - Method of preventing precipitation of a reactive substance-bound microparticle, and reagent containing the micro particle: According to the present invention, precipitation of a reactive substance-bound microparticle can be prevented in a dispersion liquid, to make a concentration of the reactive substance-bound microparticle uniform in the dispersion liquid. The present invention provides a method of preventing precipitation of a reactive substance-bound microparticle. The method includes coexisting... Agent: The Webb Law Firm, P.C.

20080261329 - Method of analysis of a mixture of biological and/or chemical components with the use magnetic particles and apparatus for its embodiment: Technical result consists in the increase of signal-to-noise ratio and, hence, increase of the accuracy of measurements, sensitivity enhancement, improvement of the reliability of the data obtained, and, at the same time, lowering analysis costs owing to the reduction of the number of operations needed, time, amount and dimensions of... Agent: Drinker Biddle & Reath (dc)

20080261330 - Apparatus components and methods of using apparatus components to detect the presence of an analyte: Apparatus components including rigid supports suitable for use in an affinity column, affinity columns, and an affinity columns in fluid communication with an analytical column, such as in a high pressure liquid chromatography (HPLC) column, are disclosed. Methods of using the apparatus components to detect the presence of one or... Agent: William D Bunch W R Grace & Co Conn Patent Department Legal

20080254541 - Chip having microchannels and a method for continuous dilution of solution: A microchannel chip and a dilution method using the same capable of continuously diluting the diverse concentrations of solution by one time fluid injection using the microfluid technology are provided. The microchannels are formed in a plastic chip using the microfluid technology, and a width, a sectional area, or a... Agent: Charles N.j. Ruggiero, Esq. Ohlandt, Greeley, Ruggiero & Perle, L.L.P.

20080254542 - Reference solution: A reference solution is provided, which comprises, in a liquid phase, at least one of a first compound and a second compound which are mutually convertible into each other, and at least one catalyst, which catalyzes the conversion between the first compound and the second compound.... Agent: Morgan Lewis & Bockius LLP

20080254543 - Simulated blood components and methods: A control and a cellular fraction for use therein and methods for making the same, including a first cellular component including a plurality of a first group of processed animal red blood cells other than human blood cells; a second cellular component including a plurality of a second group of... Agent: Dobrusin & Thennisch PC

20080254544 - Error detection and rejection for a diagnostic testing system: A system for measuring a property of a sample is provided. The system comprises a diagnostic measuring device having a memory and a diagnostic test strip for collecting the sample. The strip has embedded thereon a pattern representative of at least first data and second data, the first data being... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080254545 - Apparatus and method for biochemical analysis: An apparatus for analyzing that performs a plurality of treatment operations includes a plurality of treatment units arranged in a vertical direction of the apparatus. The apparatus for analyzing also includes a conveying mechanism configured to convey a sample between the treatment units. The sample is delivered above or in... Agent: Fitzpatrick Cella Harper & Scinto

20080254546 - A cyanine-based probe\tag-peptide pair for fluorescence protein imaging and fluorescence protein imaging methods: A molecular probe comprises two arsenic atoms and at least one cyanine based moiety. A method of producing a molecular probe includes providing a molecule having a first formula, treating the molecule with HgOAc, and subsequently transmetallizing with AsCl3. The As is liganded to ethanedithiol to produce a probe having... Agent: Wells St. John P.s.

20080254547 - Supracolonic aerodigestive neoplasm detection: The invention provides methods and materials for detecting supracolonic aerodigestive premalignant and malignant neoplasms. Specifically, the invention provides methods and materials for determining whether a stool sample from a mammal contains a neoplasm-specific marker from a neoplasm located in the supracolonic aerodigestive tissue of a mammal.... Agent: Goodwin Procter LLP Patent Administrator

20080254548 - Detection of target analytes using particles and electrodes: The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte... Agent: Morgan, Lewis & Bockius, LLP

20080254549 - Systems and methods for detecting and analyzing polymers: A detection system and methods for improving the ability of the detection system to recognize labels that are disposed on a polymer. Embodiments of the invention include schemes for selecting emitters and labels used within the system in a manner that allows an increase in the number of distinct labels... Agent: Wolf Greenfield & Sacks, P.C.

20080254550 - Drug detection kit and method: This invention relates to a kit and to a method of using the kit for the in situ detection of trace quantities of drugs on any surface. The method involves using a sampling means that is purposefully designed to sample trace elements of a drug to sample an unknown drug,... Agent: Darby & Darby P.C.

20080254551 - Immunoprecipitaion-based method to purify and characterise biological macromolecular complexes: This invention concerns an artificial adapter protein that combines an antibody-binding activity with two affinity tags and its use in isolation of antibody-antigen complexes. Using this adapter protein, complexes can be obtained at good yield and in the high purity necessary for the identification of all biological macromolecules that are... Agent: Breiner & Breiner, L.L.C.

20080254552 - Methods and devices for analyte detection: Methods for detecting one or more analytes, such as a protein, in a fluid path are provided. The methods include resolving, immobilizing and detecting one or more analytes in a fluid path, such as a capillary. Also included are devices and kits for performing such assays.... Agent: Morgan, Lewis & Bockius, LLP.

20080248577 - A method of monitoring a surfactant in a microelectronic process by fluorescence: A method of monitoring a surfactant in a microelectronic process is disclosed. Specifically, the monitoring of a surfactant occurs by studying the fluorescence or electromagnetic emission of a sample collected from a microelectronic process.... Agent: Peter A. Dimattia Patent And Licensing Department

20080248578 - Detection of explosives and other species: The present invention provides a series of systems, devices, and methods relating to the determination of explosives, such as peroxides or peroxide precursors, and other species. Embodiments of the invention may allow a sample suspected of containing an explosive (e.g., a peroxide) or other species to interact with a reactant,... Agent: Wolf Greenfield & Sacks, P.C.

20080248579 - Method of stabilizing human natriuretic peptides: The present invention relates to methods for making stable test samples that can be used in ligand-binding assays for measuring natriuretic peptides.... Agent: Paul D. Yasger Abbott Laboratories

20080248580 - Method for determining the endogenous antioxidative potential of beverages by means of esr spectroscopy: The present invention relates to a method for determining the endogenous antioxidative potential (EAP) in a beverage sample, preferably beer, wine, juice or mixtures thereof, using ESR spectroscopy. More specifically, the invention relates to a method for measuring a secondary radical, preferably a hydroxyethyl radical, which is stabilized by a... Agent: Pearl Cohen Zedek Latzer, LLP

20080248581 - Method for performing correction of blood glucose assay bias using blood hemoglobin concentration: A device and method for determining a correction factor for correcting the blood glucose assay bias based on sample hematocrit interference in a testing device using the blood hemoglobin concentration. The hemoglobin assay and the glucose assay may be performed using a single combination monitoring device.... Agent: Nixon Peabody LLP

20080248582 - Diagnostic device and method: A method of separating a cell-containing sample into a substantially cell-depleted portion, and a cell-containing portion comprising at least one of a stem cell, a lymphocyte, and a leukocyte comprises a step in which the sample is received in a vessel with at least one flexible wall. In another step,... Agent: Fish & Associates, PC Robert D. Fish

20080248583 - Quantitative and qualitative chelation measuring methods and materials: The present invention is directed to a method of assaying for the presence or absence of a metal-ligand chelate in a sample containing either a metal-ligand chelate or a free ligand. The method includes (a) reacting the sample with a luminophore to obtain either a metal-ligand-luminophore chelate and/or a ligand-luminophore... Agent: Brinks Hofer Gilson & Lione / Albion Utah Office

20080248584 - Trityl derivatives for enhancing mass spectrometry: The compounds of formula (IIa) and (IIb) may form ions of formula (I′) by either cleaving the C—X bond between X and the α-carbon atoms in the case of the compounds of formula (IIa) or dissociating X in the case of compounds of formula (IIb).... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080248585 - Protein/peptide sequencing by chemical degradation in the gas phase: A fast and sensitive method and device for protein sequencing are disclosed. The method uses a combination of Edman degradation chemistry and mass spectrometry to sequence proteins and polypeptides. A peptide degradation reaction is performed on a polypeptide or protein ion reactant in the gas phase. The reaction yields a... Agent: Intellectual Property Dept./dewitt Ross & Stevens Wisconsin Alumni Research Foundation

20080248586 - Reaction vessel, reaction vessel liquid introducing device, liquid introducing and reaction measuring device, and liquid introducing device: The invention relates to a reaction vessel, a reaction vessel liquid introducing device, a liquid introducing and reaction measuring device, and a liquid introducing device, and is directed to being able to perform temperature control of a liquid stored within the reaction vessel with a high accuracy and faithful responsiveness.... Agent: Haynes And Boone, LLP

20080248587 - Methods for verifying fluid movement: Methods for using semiconductor nanocrystals for determining fluid movement, fluid dilution and fluid removal are described. Methods for using semiconductor nanocrystals for monitoring and quantifying the amounts of solid materials dissolved in a liquid are also described.... Agent: Foley & Lardner LLP

20080248588 - Shrimp allergen, anti-shrimp allergen antibody, and use thereof: Provided is a novel shrimp allergen. The shrimp allergen of the present invention includes an isolated shrimp collagen or a polypeptide fragment thereof. According to the present invention, there is provided the novel shrimp allergen, and there are provided, using the allergen, an anti-shrimp allergen antibody, a method of detecting... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080248592 - Detection of target analytes using particles and electrodes: The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte... Agent: Morgan, Lewis & Bockius, LLP

20080248590 - Device for carrying out a biological assay: An integrated lab-on-a-chip device for carrying out an assay to detect the presence of a biological molecule in a fluid sample, the device comprising: (a) an inlet for a fluid sample; (b) one or more reaction sites each in fluid communication with the inlet; (c) one or more reagent reservoir... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080248591 - Gas bubble biosensor: The present invention describes a biosening device and method. Specifically, binding of target analyte perturbs the surface of a sensor strip so that gas bubbles are generated in solution. Said gas bubbles may be detected for determination of analyte presence in sample.... Agent: Dr. Alan Joseph Bauer

20080248593 - Method for detection of fluoride or hydrogen fluoride and detection kit: The present invention relates to a method for detecting and/or measuring the concentration of fluoride (F−) or hydrogen fluoride (HF) in a sample, comprising the steps consisting of bringing said sample, in aqueous solution, into contact with a silylated organic compound in order to obtain a measurement solution, with said... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080248589 - Sample presentation device: The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as: retention, storage, transport, concentration, positioning, and transfer. Additionally, these devices can enhance the detection and characterization of analytes. The sample presentation devices of... Agent: Mcdermott Will & Emery LLP

20080248594 - Organic non-sugar compounds for protection of biologically active molecules and conjugate labels and methods of use thereof: Provided are methods comprising the use of non-sugar organic compatible solutes for protection and preservation of the activity of biologically active molecules and conjugate labels. The methods are particularly adaptable for use in conjunction with immunoassays, such as for example, immunochromatographic test assays and may be incorporated into any test... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080241932 - Analyte detection via electrochemically generated reagent: Electrochemical devices, methods, and systems for detecting and quantifying analytes are disclosed. A chemical detection reagent is locally generated in a test solution by electrochemical reaction of a precursor compound caused to migrate into the test solution from a precursor solution separated from the test solution by a cell separator.... Agent: Koppel, Patrick & Heybl

20080241933 - Biological saw sensor: Analysing fluid samples for target biological or chemical species comprising a detector unit with a body incorporating a SAW sensor (29) for said target species, in a microfluidic channel (27) and a reader unit adapted to receive the detector unit. The reader unit includes electrical contacts with said SAW sensor... Agent: Connolly Bove Lodge & Hutz LLP

20080241934 - Methods for reducing complexity of a sample using small epitope antibodies: The present invention relates generally to methods for reducing the complexity of a sample. More specifically, the present invention relates to proteomics, the measurement of the protein levels in biological samples, and analysis of proteins in a sample using antibodies that recognize small epitopes.... Agent: Tethys Bioscience C/o Morrison & Foerster LLP

20080241935 - Methods for pathogen detection: The present disclosure relates to methods, systems, devices, and microfluidic chips that may be used for the detection of pathogens.... Agent: Searete LLC Clarence T. Tegreene

20080241936 - Multianalyte molecular analysis using application-specific random particle arrays: The present invention provides methods and apparatus for the application of a particle array in bioassay format to perform qualitative and/or quantitative molecular interaction analysis between two classes of molecules (an analyte and a binding agent). The methods and apparatus disclosed herein permit the determination of the presence or absence... Agent: Eric P. Mirabel

20080241937 - Sample analyzer and sample analyzing method: A sample analyzer and sample analyzing method perform following: a) mixing a sample with at least one of a first reagent and a second reagent, thereby preparing a measurement specimen; b) storing, in a memory, standard curve data corresponding to a reagent to be used in the step a) for... Agent: Brinks Hofer Gilson & Lione

20080241938 - Automated synthesis or sequencing apparatus and method for making and using same: An apparatus and method based on the apparatus is disclosed for automated single molecule or molecular assemblage detection via light irradiation and detection of transient FRET between a donor or acceptor bound to an immobilized single molecule or molecular assemblage and a corresponding acceptor or donor associated with, covalently bonded... Agent: Robert W Strozier, P.l.l.c

20080241939 - Sample analyzer, reagent aspirating method, and computer program product: The present invention is to present a sample analyzer which is capable of respond immediately when a need to perform analysis of multiple items arises. The sample analyzer 1 includes a table 12 capable of holding a first rack 320 and a second rack 330; a reagent dispensing arm 120... Agent: Brinks Hofer Gilson & Lione

20080241940 - Fecal sampling device and method: A specimen sampling device according to one embodiment has a first panel, a second panel, a sheet between the first and second panels for receiving the collected samples and a movable area creating metering apertures through which samples are received. The movable area is movable from a collection position, in... Agent: Stroock & Stroock & Lavan LLP

20080241941 - Reagent for measuring clotting time and method for stabilizing tissue factor: The present invention provides a reagent for measuring clotting time comprising a nonionic surfactant, a nickel ion and a tissue factor. A method for stabilizing a tissue factor, and use of a nonionic surfactant and a nickel salt for stabilizing a tissue factor are also disclosed.... Agent: Sughrue Mion, PLLC

20080241942 - Air-stable supported lipid bilayer membranes: The present invention relates to methods for fabricating air-stable supported lipid bilayer membranes. In one embodiment, the present invention relates to methods of producing supported lipid bilayer membranes stabilized by sterol groups that are covalently tethered to a solid surface. In a further embodiment, the present invention relates to air-stable... Agent: Microsurfaces, Inc.

20080241943 - Subnanomolar precipitator of thiophilic metals: A fluorescent dye-doped crystalline assay is employed for selection and detection of thiophilic heavy metal ions. While comparable in analytical performance to known solution based methodologies, the formation of crystalline analytes provides for signal amplification, and consequently, a powerful platform whose analysis is directly amenable to high-throughput video capture systems.... Agent: The Scripps Research Institute

20080241946 - Fibroblast growth factor (fgf23) and methods for use: The present invention relates to a kit for diagnosing a disorder comprising a reagent that detects FGF23 polypeptides and mutant FGF23 polypeptides.... Agent: Drinker Biddle & Reath Attn: Intellectual Property Group

20080241947 - Intestinal folate transporter: Provided is an isolated and purified DNA molecule comprising the coding region of a PCFT cDNA. Also provided is a segment of the above DNA molecule, capable of serving as a primer for amplifying at least a portion of the DNA molecule. Additionally provided is a pair of the above... Agent: Amster, Rothstein & Ebenstein LLP

20080241944 - Method of making gel drop protein biochips: A method of making a gel drop protein chip by transferring proteins, which were obtained from a cellular lysate, partitioned using two-dimensional, protein fractionation, and mixed with a polymeric matrix solution containing acrylamide/bis and glycerol, to an array; a method of making a gel drop protein chip by transferring proteins,... Agent: Barnes & Thornburg LLP

20080241945 - Peptide for differentiating osteoarthritis from rheumatoid arthritis and non-disease conditions: A method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of a peptide comprising the 15 amino acid sequence (SEQ ID NO: 1) of the human cartilage intermediate layer protein 2.... Agent: Lynn E Barber

20080241948 - Mycophenolate mofetil impurity: Provided is an impurity of mycophenolate mofetil, processes for its preparation and its use as a reference.... Agent: Kenyon & Kenyon LLP

20080241949 - Process for preparing quetiapine fumarate: Provided is an improved synthesis of quetiapine and pharmaceutically acceptable salts.... Agent: Kenyon & Kenyon LLP

20080241950 - Nucleic acid sequencing in free solution using protein polymer drag-tags: The present invention relates to systems, compositions, and methods for nucleic acid sequencing and analysis in free-solution using protein polymer drag-tags. As such, the present invention provides protein-based molecular compositions that find use as drag-tags for use in sequencing and nucleic acid analysis methods and provides systems and methods for... Agent: Casimir Jones, S.c.

20080241951 - Method and apparatus for moving stage detection of single molecular events: An apparatus and method based on the apparatus is disclosed for detecting and monitoring chemical and/or bio-chemical reactions or interactions at the single molecule level, where detection and monitoring is improved by moving the viewing field of the detector in a controlled manner. The motion of the moving frame is... Agent: Robert W Strozier, P.l.l.c

20080241952 - Sensor with holographic multiplexed image display: A holographic sensor comprising a thin film polymer matrix that undergoes a change in response to a substance to be sensed, the matrix containing within its volume a set of two or more holographic recordings, each recording providing a holographic image when the sensor is illuminated, wherein the presence or... Agent: Hamilton, Brook, Smith & Reynolds, P.C.

20080241953 - Method and apparatus for patterning a bibulous substrate: A method of patterning a bibulous substrate is disclosed. The method comprises contacting the bibulous substrate with a first surface being coated by a barrier compound, using a second surface having a predetermined pattern engraved thereon, and applying heat and pressure onto the first surface such as to pattern the... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080241954 - Methods for determining the status of copd in humans: A method of determining the status of chronic obstructive pulmonary disease (COPD) of a human that includes the steps of performing a spectral analysis of a sputum sample collected from the human; comparing the spectra produced by the analysis against a reference; and determining the status of COPD in the... Agent: Adams Intellectual Property Law, P.A.

20080241955 - Methods, mixtures, kits and compositions pertaining to analyte determination: This invention pertains to methods, mixtures, kits and compositions pertaining to analyte determination by mass spectrometry using labeling reagents that comprise a nucleophilic reactive group that reacts with a functional group of an analyte to produce a labeled analyte. The labeling reagents can be used as isobaric sets, mass differential... Agent: Orrick, Herrington & Sutcliffe, LLPIPProsecution Department

20080241956 - Method for detecting analyte and biochip: i

20080241957 - Sample analyzer, sample analyzing method, and computer program product: A sample analyzing method comprising: aspirating a sample from a sample container; preparing a plurality of measurement samples from the aspirated sample; sequentially measuring the plurality of prepared measurement samples; obtaining a plurality of measurement data for the respective measurement samples; and obtaining an analysis result of a predetermined item... Agent: Brinks Hofer Gilson & Lione

20080241961 - Drosophila g protein coupled receptors, nucleic acids, and mehtods related to the same: The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists,... Agent: Pepper Hamilton LLP

20080241960 - Insulin-like growth factor binding protein: Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of... Agent: Townsend And Townsend And Crew, LLP

20080241959 - Macrolide compounds containing biotin and photo-affinity group for macrolide target identification: i

20080241958 - Method for determining hcg levels in fluid samples: The subject invention is an immunoassay for the semi-quantitative test kit for determination of human chrionic gonadtropin (hCG) in fluid sample (such as urine) as an aid in the diagnosis of a certain stage of pregnancy. The test device includes five strips having each having a dipping end or sample... Agent: Venture Pacific Law, PC

20080241962 - Micromachined diagnostic device with controlled flow of fluid and reaction: This invention relates to a micromachined microfluidics diagnostic device that comprises one or multiple assaying channels each of which is comprised a sample port, a first valve, a reaction chamber, a second valve, a fluid ejector array, a third valve, a buffer chamber, a capture zone and a waste chamber.... Agent: Quine Intellectual Property Law Group, P.C.

20080241963 - Biochemical labeling materials and manufacturing method thereof: A biochemical labeling material and manufacturing method thereof. The manufacturing method provides a plurality of nanoparticles, bonding the nanoparticles to template molecules by molecular imprinting, polymerizing the nanoparticles to form a matrix with uniformly-distributed template molecules, finally removing the template molecules from the matrix to reveal a detection group of... Agent: Sughrue Mion, PLLC

20080241964 - Material for improving sensitivity of magnetic sensor and method thereof: The present invention relates to a capture agent member being used in a magnetic sensor to detect the presence or concentration of a target substance in a test solution by detecting the presence or number of the magnetic marker, wherein the capture agent member contains a capture agent for capturing... Agent: Fitzpatrick Cella Harper & Scinto

20080241966 - Apparatuses and methods for detecting an analyte: A method and apparatus for detecting an analyte includes a sensor chamber for detecting an analyte, an analyte feed chamber, a distributor, and a controller for controlling the transport medium flow. The distributor includes an annular channel with four connections with a switchable isolating device between two connections. The controller... Agent: Roylance, Abrams, Berdo & Goodman, L.L.P.

20080241965 - Methods for validating the presence of and characterizing proteins deposited onto an array: A method of determining if proteins have been transferred from liquid-phase protein fractions to an array comprising staining the array with a total protein stain and imaging the array, optionally comparing the staining with a standard curve generated by staining known amounts of a known protein on the same or... Agent: Barnes & Thornburg LLP

20080241967 - Radioimmunoassay using nanoparticle-antibody conjugates: A radioimmunoassay method for determining the quantity of an analyte of interest in a sample is disclosed. The analyte of interest may be an antigen or other chemical entity. A known antibody to the antigen or other entity is employed and is conjugated to a functionalized nanoparticle. Because of the... Agent: Leigh P. Gregory