Chemistry: analytical and immunological testing inventions 09/08

20080233652 - Set of calibration standards: The present invention relates to a standard calibration set comprising at least three calibration standards that consist of a molded article made of a thermoplastic polymer which contains the elements Cd, Cr, Pb, Hg and Br, with the Cr:Pb:Hg:Br:Cd ratio being different in each of the three calibration standards, and... Agent: Hahn & Voight PLLC

20080233653 - System and method for processing chemical substances, computer program for controlling such system, and a corresponding computer-readable storage medium: To this end, a system for processing chemical substances in a laboratory setting is proposed, wherein the system includes components for carrying out basic chemical processing operations. The components can be modularly combined according to presettable sequences of process steps for processing chemical substances and have matching modular dimensions. The... Agent: Norris, Mclaughlin & Marcus, P.A.

20080233654 - Tagging system: A method of tracing an aqueous liquid, particularly an aqueous urea used for addition to a selective catalytic reduction system to remove NOx from diesel exhaust includes adding a tracer comprising a pre-determined amount of a phenol to the liquid. The liquid can subsequently be identified by reacting a sample... Agent: Ratnerprestia

20080233655 - Screening for lysosomal storage disease status: A method of ascertaining the LSD (Lysosomal storage disorder) status of an individual comprising taking a tissue or body fluid sample from the individual and estimating a level in the sample of each of three or more compound indicators. The indicators reflect the level of respectively each of three or... Agent: Coleman Sudol Sapone, P.C.

20080233656 - Method for detecting a fuel additive component: A process for qualitatively or quantitatively detecting a fuel additive component which is part of an analyte comprising a fuel and/or further fuel additive components, by contacting the analyte with an indicator and determining the change, caused by the interaction between fuel additive component and indicator, in the color properties... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080233657 - Methods to predict the outcome of treatment with antidepressant medication: The invention provides a method for determining the outcome of treatment with an antidepressant medication in a patient. In particular, the invention provides a method of screening patients to identify those patients with a decreased risk of non-response to treatment with antidepressant medication comprising: (a) obtaining a sample of genetic... Agent: Leydig, Voit & Mayer, Ltd.

20080233658 - Environmental fluorescent sensors: The present disclosure relates to a fluorescence marker such as quantum dots and their use as sensors which may rely upon a change in fluorescence output upon exposure to a given environmental condition. The variation in fluorescence output may then be utilized as an indication of exposure to a given... Agent: Grossman, Tucker, Perreault & Pfleger, PLLC

20080233659 - Process of screening for alpha-thalassemia carrier using immunochromatographic strip test: The invention provides a device and method for the rapid identification of patients suspected of having thalassemia. The invention provides a test strip for the aqueous detection of thalassemia related proteins in whole blood. The test strip includes antibodies specific to the gamma 4, (γ4) protein and provides easy visual... Agent: Dorsey & Whitney LLP Intellectual Property Department

20080233660 - Solid phase labeling method: The invention provides for the labeling of antibodies with a fluorescent label, using a solid support comprising an affinity for an Fc portion of an antibody. Thus, the invention provides a method for labeling an antibody or fragment thereof with a fluorescent label, comprising the steps of immobilizing an antibody... Agent: Birch Stewart Kolasch & Birch

20080227206 - Method and system for determination of molecular interaction parameters: A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations... Agent: Ge Healthcare Bio-sciences Corp. Patent Department

20080227207 - Automated colorimetric polysaccharide assays: A method of automated determination of saccharide concentration is provided herein. The method includes preparing one or more saccharide standards and one or more diluted polysaccharide test samples, transferring a portion of the one or more saccharide standards and the one or more diluted polysaccharide test samples along with a... Agent: Alston & Bird LLP

20080227208 - Devices and methods for detection of occult blood: The present invention relates to devices and methods for the detection of occult blood in a test sample. These devices and methods can detect the presence of one or more of the following components of occult blood: hemoglobin, transferrin, hemoglobin-haptoglobin complex, and albumin. Methods for the detection of occult blood... Agent: Venture Pacific Law, PC

20080227209 - Methods, kits and devices for analysis of lipoprotein(a): Methods for optically detecting lipoproteins, in particular lipoprotein(a), in a sample. In some embodiments, the methods include contacting a sample with an associative lipophilic dye, subjecting the sample to electrophoretic separation through a separation medium, and detecting the dye. Kits comprising microchips for performing a separation of lipoproteins, including lipoprotein(a),... Agent: Agilent Technologies Inc.

20080227210 - Home test for glycated albumin in saliva: A home test for measuring glycated albumin levels in saliva. The saliva sample is collected at home using a standardized saliva collection kit and mailed to a testing laboratory that performs the test and reports the result directly back to the customer via the internet. The home test can be... Agent: Henry J. Smith

20080227211 - Compositions and methods for free-solution conjugate nucleic acid analysis: The present invention provides compositions and methods for performing free-solution conjugate analysis of nucleic acid molecules. For example, the present invention provides multiplexed single-base extension assays for genotyping. In particular, the present invention provides a series of disperse polyamide “drag tags” for use in achieving high-resolution separation of nucleic acid... Agent: Casimir Jones, S.c.

20080227212 - Process for identifying existence of single nucleotide polymorphism without dna sequencing: A process for detecting the presence of a mutation in an oligonucleotide strand such as a DNA strand from a gene without the need for DNA sequencing is provided. The inventive process provides a rapid pre-test to screen for the presence or absence of a mutation in a target gene... Agent: Gifford, Krass, Sprinkle,anderson & Citkowski, P.c

20080227213 - Rna targeting compounds and methods for making and using same: wherein j is an integer from 1 to 100; each i is the same or different and is zero or an integer from 1 to 100; each Z1 represents the same or different linking moiety; each R1 is the same or different and represents an alkyl group or an aryl... Agent: Peter Rogalskyj, Esq. The Law Office Of Peter Rogalskyj

20080227214 - Method for the hydrocyanation of 1,3-butadiene: A process is described for preparing 3-pentenenitrile by hydrocyanating 1,3-butadiene in the presence of at least one catalyst, wherein unhydrocyanated 1,3-butadiene is removed from the effluent of the hydrocyanation and recycled into the process, and the recycled 1,3-butadiene is monitored for the content of hydrogen cyanide.... Agent: Connolly Bove Lodge & Hutz LLP

20080227215 - Method and arrangement of measuring acidity for other chemical or physical property of a gas: A method and an arrangement of measuring acidity or other chemical or physical property of a gas. The invention comprises a membrane having optical indicator molecules bound to a microporous matrix arranged to be placed into contact with the gas to be measured, the optical indicator molecules changing their colour... Agent: Buchanan, Ingersoll & Rooney PC

20080227216 - Liquid tester: A liquid testing device for determining the value of at least one property of a liquid. The liquid testing device includes a planar base and at least one test section, located on the planar base, with a reference color section located adjacent to the test section, which exhibits a color... Agent: Edward Langer C/o Shiboleth Yisraeli Roberts Zisman & Co.

20080227217 - Sample-liquid analysis disc and method for analyzing sample mixture liquid: A reaction of a sample mixture liquid is detected accurately, by allowing a solid reagent to be dissolved and reacted in a liquid sample quickly and accurately. A disc main body, and at least one sample mixing unit provided at the disc main body are provided, and the sample mixing... Agent: Mcdermott Will & Emery LLP

20080227218 - Target substance detection method and target substance detection kit: A target substance detection method for detecting a target substance in a specimen, comprises the steps of contacting with a specimen a target substance detecting element comprised of a base, a metal structure and a first capturing body for capturing a target substance; contacting with the target substance detecting element... Agent: Fitzpatrick Cella Harper & Scinto

20080227219 - Electrochemiluminescent assay: Disclosed herein are compositions that may be used in an assay, such as an immunoassay, for detecting and/or quantifying at least one analyte of interest, such as an antigen. Also disclosed are control/calibrator compositions and methods for preparing control/calibrator compositions that may be used in assays, such as immunoassays, methods... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20080227220 - Lateral flow binding assay: Provided is a test device, a test method and a test kit for the detection of the presence or absence of an analyte in a fluid sample, based on a device comprising a backing with a first end (A) and a second end (B) and consecutively going from first end... Agent: Nixon & Vanderhye, PC

20080227221 - Fluorescence polarization-based homogeneous assay for aflatoxins: A homogeneous assay for determining the aflatoxin content in agricultural products uses the technique of fluorescence polarization. A solvent is used to extract aflatoxins from a sample of the agricultural product. A mixture is prepared by combining the extract with a tracer and with a monoclonal antibody specific for aflatoxin.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080227222 - Method for the detection of target molecules by fluorescence polarization using peptide mimics: The inventive subject matter relates to a method of measuring non-protein hydrophobic and protein target antigens by competitive fluorescence polarization using peptide mimics as competitors. The peptide mimics used in the inventive method contain conformational epitopes not represented in the linear sequence. The method can be used in the detection... Agent: Naval Medical Research Center Attn: (code 00l)

20080220529 - System and method for fertilizer selection: A system, method and computer readable program is disclosed for facilitating the selection of a fertilizer. The basis for selecting the fertilizer includes determining the water type based on the water chemistry and taking into consideration the crop type that is to be grown.... Agent: Manatt Phelps And Phillips Robert D. Becker

20080220530 - Biomarkers: The invention relates to methods for diagnosing or monitoring psychotic disorders such as schizophrenic or bipolar disorders, comprising measuring the level of one or more biomarker(s) present in a cerebrospinal fluid sample taken from a test subject, said biomarker(s) being selected from the group consisting of: glucose, lactate, acetate species... Agent: Saliwanchik Lloyd & Saliwanchik A Professional Association

20080220531 - Stimuli-responsive magnetic nanoparticles and related methods: Stimuli-responsive magnetic nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles.... Agent: Christensen, O'connor, Johnson, Kindness, Pllc

20080220532 - Separation of charged solutes by electrostatic repulsion-hydrophilic interaction chromatography: In one aspect, a method of performing electrostatic repulsion-hydrophilic interaction chromatography on a protein, peptide, or amino acid includes providing a column having an anion-exchange material at a pH of less than about 4, and eluting the compound using a mobile phase comprising an amount of organic solvent sufficient to... Agent: Banner & Witcoff, Ltd.

20080220533 - Measuring method for total organic carbon, measuring method for total nitrogen and measuring apparatus for the methods: Disclosed herein is a method for measuring total organic carbon without the influence of nitrogen components. The method for measuring total organic carbon includes the steps of: (1) adjusting the hydrogen ion concentration of sample water to between pH 4 and pH 6; (2) decomposing organic matter and nitrogen compounds... Agent: Cheng Law Group, Pllc

20080220534 - Nanoporous material for aldehydes with direct optical transduction: The invention concerns a method for detecting and/or assaying and/or capturing at least one aldehyde, preferably formaldehyde, including a step of contacting a gas stream with a material comprising a nonporous metal oxide sol-gel matrix, said matrix containing at least one probe molecule bearing at least one reactive function capable... Agent: Miller, Matthias & Hull

20080220535 - Photoelectrocatalytic fluid analyte sensors and methods of fabricating and using same: Fluid analyte sensors include a photoelectrocatalytic element that is configured to be exposed to the fluid, if present, and to respond to photoelectrocatalysis of at least one analyte in the fluid that occurs in response to impingement of optical radiation upon the photoelectrocatalytic element. A semiconductor light emitting source is... Agent: Myers Bigel Sibley & Sajovec

20080220536 - Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates: The present invention relates to the use of “tethering” to identify compounds that modulate enzymatic activity.... Agent: Heller Ehrman LLP

20080220537 - Substrates and methods for selective immobilization of active molecules: Substrates and methods for providing increased selectivity in the immobilization of active molecules of interest in desired locations of substrates for use in analytical operations and particularly optical analytical operations.... Agent: Pacific Biosciences Of California, Inc.

20080220538 - Novel cancer associated antibodies and their use in cancer diagnosis: The present invention relates to an antibody having specificity for a polypeptide comprising an amino acid sequence of SEQ ID No:2 or an isoform thereof or a polypeptide comprising SEQ ID NO:2.... Agent: Merchant & Gould Pc

20080220539 - Apparatus and method for determining an analyte in a fluid: The invention relates to an apparatus and a method for determining an analyte in a fluid. Provided in the device is a stirring zone formed in an optionally microfluidic three-dimensional structure, into which stirring zone a sample of the fluid can be introduced and in which there is a stirring... Agent: Roche Diagnostics Operations Inc.

20080220540 - Method for purifying cancer-specific proliferating cell nuclear antigen: The method for developing an antibody that exclusively binds to csPCNA.... Agent: Whiteford, Taylor & Preston, LLP Attn: Gregory M Stone

20080213902 - Slide holder for staining procedures: Improvements in FISH staining employing a microscope slide holder which allows for batch processing of slides in the hybridization process.... Agent: Kelley Drye & Warren LLP

20080213903 - Automatic analyzer and the analyzing method using the same: An automatic analyzer which assures uniformity in mixing effects regardless of sample quantity and test item and thus produces analysis results with high repeatability. The analyzer includes a device for adding a conditioning liquid into a reaction chamber so that the quantity of liquid in the reaction chamber becomes a... Agent: Mattingly, Stanger, Malur & Brundidge, P.C.

20080213904 - Monitoring drug compliance, food-intake or toxin-intake using non-invasively-read labels: A system is disclosed for monitoring a property of an ingested or in-taken drug, food, drink or toxic substance, non-invasively or minimally invasively, which can also identify the subject person being monitored, if desired. The system comprises: a means of labeling the substance with a labeling media to have a... Agent: David W. Collins Intellectual Property Law

20080213906 - Compositions and methods for combining protein precipitation and solid phase extraction: A composition, method and device for the preparation of biological samples for subsequent LC-MS analysis using a combined and concurrent protein precipitation and solid phase extraction (SPE) process is described. Through an integrated combination of protein precipitation, filtration, and SPE using a novel zirconia-coated chromatographic media, interfering compounds, such as... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080213905 - Methods of assessing the need for and the effectiveness of therapy with antioxidants: The invention relates to diagnostic methods for assessing the need of a subject for treatment with an anti-oxidant, or alternatively, for determining the utilization efficiency and ultimate effectiveness of anti-oxidant therapy in subjects having been treated with antioxidants. More specifically, the methods of the present invention are particularly useful in... Agent: Ladas & Parry LLP

20080213907 - Protein markers for the diagnosis and prognosis of ovarian and breast cancer: Plasma samples of ovarian and breast cancer patients were used to search for markers of cancer, using two-dimensional gel electrophoresis and MALDI TOF mass spectrometry. Truncated forms of cytosolic serine hydroxymethyl transferase (cSHMT), T-box transcription factor 3 (Tbx3) and utrophin were aberrantly expressed in samples from cancer patients, as compared... Agent: White & Case LLP Patent Department

20080213908 - Flame detector: Improved operating modes of a micro counter-current flame ionization detector (μFID) are demonstrated. By operating the flame inside the end of a capillary gas chromatography (GC) column, the effective cell volume enclosing the flame is considerably reduced and results in significantly lower gas flows being required to produce optimal sensitivity... Agent: Christensen, O'connor, Johnson, Kindness, PLLC

20080213910 - Method for blocking non-specific protein binding on a functionalized surface: A method of blocking non-specific protein binding on surfaces, such as protein-coated biosensor surfaces.... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080213909 - Pharmaceutical packaging assay: A pharmaceutical packaging assay for the determination of drug adsorption to the packaging surface(s) is described. The assay described utilizes fluorescent labeling of drugs in various formulations to determine the best packaging surface for drug stability as a function of adsorption.... Agent: Millen, White, Zelano & Branigan, P.C.

20080213911 - Method of analyzing c-terminal amino acid sequence of peptide: An analyte peptide is selectively degraded sequentially by using an alkanoic anhydride (S101). The original peptide and a series of degradation reaction products having peptide in which one or more C-terminal-sided amino acids are deleted, are subjected to a certain posttreatment (S102). The molecular weight of the reaction products is... Agent: Sughrue Mion, PLLC

20080213912 - System and methods for stretching polynucleotides: Apparatus and methods are described for achieving uniform stretching of polynucleotides in hybrid electrophoretic-gel, micro-constricting microfluidic channels. Polynucleotides in normally relaxed configurations are driven by an electric field along a microfluidic channel. The polynucleotides thread through a porous gel barrier formed in the channel and extend into a constriction where... Agent: Choate, Hall & Stewart LLP

20080213913 - Combustion analysis apparatus and method: A method and apparatus for combustion analysing a sample in a combustion analyzer (120,160,180), where the sample comprises a proportion of sulphur. The sample is supplied to the combustion analyzer and combusted to produce combustion products, comprising a yield of sulphur dioxide for detection. Nitrogen monoxide or a source of... Agent: Haynes And Boone, LLP

20080213914 - Method and system for measuring ron and mon values for light distillates: A method and a system is disclosed for determining RON and/or MON values from constant volume combustion chamber apparatuses capable of producing pressure versus time combustion profiles having a fast combustion region and a slow combustion region, where data from the two regions is used to compute RON and/or MON... Agent: Robert W Strozier, P.l.l.c

20080213915 - System and method for the measurement of multiple fluorescence emissions in a flow cytometry system: A system and method for the measurement of multiple fluorescence emissions in a flow cytometry system is disclosed where each excitation light source is modulated with a different frequency. A single detector is used to collect the fluorescent emissions excited by all light sources, and the emissions are segregated using... Agent: Woodard, Emhardt, Moriarty, Mcnett & Henry LLP

20080213916 - Allosterically catalyzed signal amplification in chemical and biological sensing: Coordination complexes having at least two structural conformations are disclosed. The coordination complexes contain at least one metal center and at least one hemi-labile ligand, and change structural conformations due to the presence or absence of allosteric effectors. Methods of detecting an analyte using the coordination complexes are also disclosed.... Agent: Marshall, Gerstein & Borun LLP

20080213917 - Luminescent macrocyclic lanthanide complexes: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary... Agent: Morgan, Lewis & Bockius LLP (sf)

20080213918 - Polynucleotides encoding two novel human g-protein coupled receptors, hgprbmy28 and hgprbmy29, and splice variants thereof: The present invention provides novel polynucleotides encoding HGPRBMY28 and HGPRBMY29 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding splice variants of HGPRBMY29 polypeptides, HGPRBMY29v1 and HGPRBMY29v2. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. Also provided are vectors,... Agent: Louis J. Wille Bristol-myers Squibb Company

20080213919 - Functionalized fluorescent nanocrystals, and methods for their preparation and use: Functionalized fluorescent nanocrystal compositions and methods for making and using these compositions are disclosed. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals... Agent: Invitrogen Corporation C/o Intellevate

20080213920 - Diagnostic detection device: The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device comprises a labeled conjugate comprising a... Agent: Church & Dwight Co., Inc.

20080213921 - Immunoassay methods: The invention generally relates to the field of diagnostic or prognostic assays and in particular relates to assays for the detection of antibodies in a sample comprising patient bodily fluid, wherein such antibodies are used as biological markers of a disease state or disease susceptibility. The assay is based on... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20080213922 - Method and system for identification of antigen: There is provided a method for the identification of antigens recognized by a given antibody. In particular the method provides for characterization of the epitope recognized by the antibody and for purification based on the physico-chemical properties of the antigen. The characterization facilitates subsequent analysis of the antigen for identification... Agent: Bereskin And Parr