Chemistry: analytical and immunological testing inventions 08/08

20080206874 - Analysis of functional fluids: The present invention relates to using an aerosol, mist, spray, liquid or semi liquid delivery system for the reagent solution containing the indicator or marker. This system comprises a reagent containing the indicator or marker that produces a color in the presence of reactants such as basic components.... Agent: The Lubrizol Corporation Attn: Docket Clerk, Patent Dept.

20080206875 - Methods for detecting and localizing dna mutations by microarray: This disclosure provides methods for detecting and localizing DNA mutations by DNA microarray. In various embodiments, the described methods include use of restriction endonuclease(s) and/or mismatch-recognition nuclease(s) to detect and/or localize mutations. In one representative method, reference and target DNA are digested using one or more restriction endonucleases, resultant DNA... Agent: Klarquist Sparkman, LLP

20080206876 - Instruments for the selective and direct detection of free metals in fluids and methods to diagnose metal-related diseases and determine pharmacologic dosing regimens: Instruments for the selective and direct detection of free metals in fluids and methods to diagnose metal-related diseases and determine pharmacologic dosing regimens are disclosed.... Agent: Garvey Smith Nehrbass & North, Llc

20080206877 - Reactors for selective enhancement reactions and methods of using such reactors: Micro-reactors for selective enhancement of ligands by exponential enrichment (ISOS) include a reactant chamber defined in a fluoropolymer. A target exposure aperture controls a surface area, crystal face or orientation and surface features of a target that is exposed to a random mixture of candidate molecules. The surface area of... Agent: Klarquist Sparkman, LLP

20080206879 - Analysis of functional fluids using a redox indicator: The present invention relates to the analysis of the quality of functional fluids. In particular, the invention relates to using a stable redox indicator that produces a color at the presence of oxidation byproducts in a functional fluid.... Agent: The Lubrizol Corporation Attn: Docket Clerk, Patent Dept.

20080206878 - Method of analyzing basestocks for low temperature properties: A process for producing lube basestocks involving solvent dewaxing a waxy feed to produce at least a partially dewaxed lube oil boiling range stream and then hydrodewaxing the partially dewaxed lube oil boiling range stream to produce a lube basestock.... Agent: Exxonmobil Research & Engineering Company

20080206881 - Diagnostic marker for neurodegenerative diseases: For neurodegenerative diseases such as amyotrophic lateral sclerosis the prediction of disease progression or response to therapy based on phenotypic parameters is very difficult and inaccurate. The measurement of the serum protein carbonyl content allows a quantitative and early diagnosis of these diseases. It enables the monitoring of the disease... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080206880 - Blood coagulation test cartridge, system, and method: A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower major sides and a minor sidewall encloses a test chamber having a test chamber pivot element and... Agent: Medtronic, Inc.

20080206882 - Apparatus and method for detecting incomplete combustion in a combustion analyzer: Apparatus and method for determining incomplete combustion in a combustion analyzer comprising a combustion chamber (60). A sample is supplied to the combustion chamber and combusted to produce combustion products. A target gas characteristic of incomplete combustion of the sample is detected in the combustion products by a target gas... Agent: Haynes And Boone, LLP

20080206883 - Hplc method for separation and detection of hydromorphone and related opioid pharmacophores: HPLC methods are provided to separate and detect morphinone, morphine, and dihydromorphine in the presence of hydromorphone. The isocratic HPLC methods employ ion-pair solute-solute ion-exchange mobile phase techniques in reversed phase chromatography. Method conditions in the disclosure provide separation and quantification of opioid pharmacophores in accordance with federal guidelines for... Agent: Merchant & Gould Pc

20080206884 - Sensor system with actuated structure releasing a coloured indicator: The invention relates to a sensor system for detecting a target substance, and for providing visual indication of a presence of the target substance. The sensor system comprising at least a first fluid system, and a second fluid system containing a coloured or colour inducing indicator substance. The sensor system... Agent: Knobbe Martens Olson & Bear LLP

20080206885 - Environmentally sensitive fluorophores: The present invention provides novel fluorophore compounds.... Agent: Timothy Oyer Wolf, Greenfield & Sacks

20080206886 - Large stoke shift dye used for optical imaging: The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relates to a method for making a dye-conjugate utilizing the novel dye and a method... Agent: Andrew J. Anderson Patent Legal Staff

20080206887 - Methods for identification and quantification of multicomponent-fluid and estimating fluid gas/ oil ratio from nmr logs: A method for determining a proportion of a hydrocarbon constituent in a mixture including at least one hydrocarbon, includes determining at least one nuclear magnetic resonance (NMR) property for at least one hydrocarbon constituent in the mixture; correlating an NMR response for the property for each hydrocarbon constituent in the... Agent: Cantor Colburn LLP- Baker Atlas

20080206888 - Screening using polarization anisotropy in fret emissions: Methods and apparatus are described for detecting specific binding between first and second chemical entities. The first chemical entity in association with a first fluorophore is immobilized. The second chemical entity is allowed to bind with the immobilized first chemical entity. The second chemical entity is or becomes coupled to... Agent: Beyer Weaver LLP

20080206889 - Comparative multiple analyte assay: Methods for measuring the relative amount of two or more analytes of interest in a fluid sample, as well as kits useful in the methods, are disclosed. The methods involve assays that utilize a solid phase apparatus with a membrane having an application point and at least two sample capture... Agent: Hamilton, Brook, Smith & Reynolds, P.c.

20080206890 - Bis(2,9-di-tert-butyl-1,10-phenanthroline)copper(i) complexes, methods of synthesis, and uses therof: The present invention provides homoleptic and heteroleptic copper(I) complexes having sterically demanding ligands, such as the bis(2,9-di-tert-butyl-1,10-phenanthroline)copper(I) complex and related complexes, methods of synthesis of these complexes and uses thereof. These copper(I) complexes are useful for various applications including photovoltaic cells, light-emitting electrochemical cells, and analyte sensor systems.... Agent: Quarles & Brady LLP

20080206892 - Rapid magnetic biosensor with integrated arrival time measuremnt: The invention provides a method, a device and a system for determining a concentration of at least one sort of polarizable or polarized magnetic labels in a fluid, the sensing surface comprising at least one sort of binding sites capable of specifically attaching to at least one sort of biological... Agent: Philips Intellectual Property & Standards

20080206891 - Synthetic antiferromagnetic nanoparticles: The present invention provides a synthetic antiferromagnetic (SAF) nanoparticle. The SAF nanoparticle includes at least two ferromagnetic layers and at least one non-magnetic spacer layer. The spacer layer is situated in between planar surfaces of the ferromagnetic layers. The saturation field of the SAF nanoparticle is tunable by the geometry... Agent: Lumen Patent Firm, Inc.

20080206893 - Biosensor and method: Surface plasmon resonance (SPR) sensor biointerface with a rigid thiol linker layer and/or interaction layer ligand loading with reversible collapse and/or iron oxide nanoparticle sensor response amplification.... Agent: Texas Instruments Incorporated

20080206894 - Bioresponsive hydrogels: The invention is a structure capable of detecting a target molecule, the invention including a functionalized polymer matrix having chemically reactive groups and at least one biomolecule attached to the chemically reactive groups to form a surface-modified bioresponsive polymer matrix.... Agent: Troutman Sanders LLP

20080199962 - Qualitative assay of extra-virgin olive oils: A methodology that enables introduction of an innovative assay for evaluating the extra-virgin olive oil (EOO), based upon the quantification of the main components of the saponifiable and non-saponifiable fractions of EOOs and upon its total antioxidizing power.... Agent: Young & Thompson

20080199963 - Method of determining acid content: A method for determining the TAN value of a hydrocarbon-containing composition, in which the sample is cleared of free water, heated to an elevated temperature in an oxygen free environment, conditioned at the elevated temperature for an extended period of time, cooled down to a temperature near to room temperature,... Agent: Reinhart Boerner Van Deuren S.c. Attn: Linda Kasulke, Docket Coordinator

20080199965 - Method for the identification of proteins folding inhibitors: The present invention relates to a method for the identification of peptide inhibitors of the folding and thus of the biological function(s) of proteins which do not create resistance. In particular, the invention relates to inhibitors of viral enzymes with a high mutation rate.... Agent: Steinfl & Bruno

20080199964 - Site-specific installation of methyl-lysine analogues into recombinant histones: The present invention provides reagents and methods for the introduction of analogues of methyl or acetyl lysine into histone proteins.... Agent: Townsend And Townsend And Crew, LLP

20080199967 - System for detection of s-nitrosoproteins: The present invention describes a novel, simplified method for detecting and monitoring the presence of nitrosylated proteins, such as S-nitrosoproteins, in a biological sample using fluorescence detection. The present invention further describes a method which can both quantify and identify the nature of nitrosylated proteins, which method is useful for... Agent: Fish & Richardson PC

20080199966 - Vitro method for the diagnosis of neurodegenerative diseases: An in vitro method for the detection, determination of severity and monitoring and prognosis of neurodegenerative diseases is disclosed. The presence and/or concentration of the physiologically inactive proadrenomedullin (proADM) partial peptide, in particular, the midregional proADM partial peptide, is determined in a biological fluid of a patient who is suffering... Agent: Heslin Rothenberg Farley & Mesiti PC

20080199968 - Method of forming signal probe-polymer: To solve a problem occurring in the PALSAR method that a polymer would be formed in the state of unbound to a captured test gene and thus affect the quantitative characteristics as a nonspecific signal, it is intended to develop a technique whereby the polymer formation is controlled in the... Agent: Wenderoth, Lind & Ponack, L.L.P.

20080199969 - Method of monitoring bulk (total) microbiological activity in process streams: An apparatus and method for monitoring and controlling microbiological activity in a process stream by measuring dissolved oxygen is disclosed.... Agent: Peter A. Dimattia Patent And Licensing Department

20080199970 - Chemical sensing device: This invention relates to a chemical sensing device for detecting an analyte. The device comprises a light source; at least one luminescent reagent which is capable of luminescing when irradiated by the light source wherein the luminescence of the luminescent reagent is modifiable by the analyte thereby changing the generation... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080199971 - Integrated membrane sensor: A system for using the sensors is described. There are disposable cartridges with a backing that supports the sensors and membrane is described. The integrated sensor in the cartridge is designed to be discarded after use. Also, label excitation sources are provided. The multi sensor array chip can be configured... Agent: Diagnostic Biosensors, LLC

20080199972 - Spectroscopic method for the detection of analytes: The present invention relates to methods for the detection of one or more analytes, in particular pathogens, viruses, prions, bacteria, parasites, pharmaceuticals, antibiotics, cytostatics, psychoactive substances, narcotics, analgesics, cardiac drugs, metabolites, coagulation inhibitors, hormones, interleukins and cytokines, performance-enhancing drugs, drugs, toxins, noxious substances, pesticides, insecticides, wood preservatives, herbicides, fungicides, explosives,... Agent: J C Patents, Inc.

20080199973 - Hydrophilic chemiluminescent acridinium labeling reagents: In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydrophobicity of the acridinium ring system to produce a more soluble label which can be attached... Agent: Foley & Lardner LLP

20080194034 - Method and apparatus for automated rapid immunohistochemistry: A sample processing system that may be configured to achieve parallel or coincidental sample processing such as histochemical processing may involve a plurality of samples arranged for coincidental movement perhaps by use of angular microscopic slide movements to cause processing activity that may include repeated elimination and reapplication of a... Agent: Santangelo Law Offices, P.c.

20080194033 - Method and device for determining the concentration of nitrite: s

20080194035 - Fuel compositions: A Fischer-Tropsch derived fuel component is provided in a fuel composition to alter the spectroscopic response of the composition to the presence of a spectroscopically active indicator. The Fischer-Tropsch derived component may be used to increase the detectability of the indicator, and/or to increase the resolution of an analytical test... Agent: Shell Oil Company

20080194036 - Method for determining coagulation activation and device for carrying out said method: The invention relates to a method for determining the generation of thrombin or factor Xa, said generation of activated coagulation factors in various sample materials, such as whole blood or plasma with different thrombocyte quantities, being triggered by phospholipid micelles with different tissue factor contents (0 to 1000 pM). According... Agent: K.f. Ross P.c.

20080194037 - Apparatus and methods for detecting metal concentration in an atmosphere: The present invention provides methods for detecting metal concentration from an area including compounding a solution that includes a metal dissolved by a solvent, and a reagent combined with metal ions dissolved in the solution and referring a difference of absorption rates between a compound of the solvent and reagent... Agent: Myers Bigel Sibley & Sajovec

20080194038 - Method for study, determination or evaluation: It is intended to provide a method for studying, determining or evaluating a pharmacological effect such as an effect on fibromyalgia, an analgesic effect or an antistress effect of a test substance by administering the test substance to a SART stress-loaded animal and then subjecting the brain tissue to expression... Agent: Oliff & Berridge, Plc

20080194039 - Method of detecting gene mutation: There is provided a method of detecting a gene insertion or deletion mutation, includes the steps of reacting a target nucleic acid with a wild-type probe and a mutant-type probe, detecting the amount of the target nucleic acid bound to the each probes, and comparing the amount of the target... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.c.

20080194040 - Optical blood gas sensor for real time measurement: An optical gas concentration sensor and method for measuring blood gas based on the light adsorption sensing technique are disclosed. The optical gas concentration sensor comprises a light source, a photo detector, and a gas filtering membrane for separating the indicator and a liquid. A gas in the liquid diffuses... Agent: Wpat, Pc

20080194041 - Integrated device for analyte, testing, confirmation, and donor identity verification: The present invention provides an apparatus for fluid sample collection and analyte testing, including a sample receiving member and at least one membrane test strip, and optionally a sample retention member, fingerprint acquisition pad, and/or fluid collector. It also provides a fluid collection apparatus having an absorbent material, compression element,... Agent: Hunton & Williams LLP Intellectual Property Department

20080194042 - Assays for disease-associated crystals in biological samples: Methods of assaying for disease-associated crystal species in biological samples are described. Such methods involve contacting a patient sample with an excess of a detectable crystal-tagging compound reactive with a plurality of crystal species under conditions that allow the detectable crystal-tagging compound to react with a plurality of crystal species,... Agent: Biotechnology Law Group C/o Portfolioip

20080194043 - Detection methods using timp1: The present invention relates to a method for detecting the presence of colorectal cancer in an individual, wherein colorectal cancer is detected by detecting the presence of Reg1α or TIMP1 nucleic acid or amino acid molecules in a clinical sample obtained from the patient, wherein Reg1α or TIMP1 expression is... Agent: Siemens Corporation Intellectual Property Department

20080194044 - Surface-enhanced lanthanide chelates: A lanthanide chelate is linked to a noble metal substrate at a proximity wherein the substrate enhances a fluorescent emission of the lanthanide by at least 20-fold when the chelate is illuminated at an excitation wavelength that induces a transition in the lanthanide that results in the fluorescent emission.... Agent: Richard Aron Osman

20080188002 - Method and apparatus for removing selenium oxide in a sample, and method and apparatus for measuring mercury in coal combustion exhaust gas by using the same: There is provided a method and apparatus for removing selenium oxide in a sample as well as a method and apparatus for measuring mercury in coal combustion exhaust gas by using the same. The apparatus for removing selenium oxide in a sample, comprising: (1) a heating introduction path for heating... Agent: Snell & Wilmer L.L.P.

20080188003 - Vinyl ends method: A method for the measurement of vinyl ends concentration in a polyester polymer by dissolving the polymer in a liquid solution with fluorinated carboxylic acid or fluorinated carboxylic anhydride, optionally heating the liquid solution or the mixture to a temperature between about 30° C. and 300° C., subjecting the resulting... Agent: Steven A. Owen Eastman Chemical Company

20080188004 - Assay for diabetes: An assay for testing a subject for diabetes or a predisposition to diabetes including analyzing a biological fluid from a subject for the presence of one or more proteins selected from the group consisting of Alpha 2 macroglobulin, Apolipoprotein AII, Immunoglobulin alpha heavy chain constant region, Immunoglobulin mu chain C... Agent: Barnes & Thornburg LLP

20080188005 - Inhibition of mismatch hybridization by a universal competitor dna: Provided herein are compositions and methods for enhancing the relative efficiency of hybridization between target nucleic acids and capture probes compared to target variants and capture probes.... Agent: Knobbe Martens Olson & Bear LLP

20080188006 - Method for measuring hypochlorite ion: o

20080188007 - Fluorescent single chain antibody and its use in detection of analytes: A fluorescent single chain antibody construct is provided comprising a single chain antibody reactive with a target analyte and conjugated with a fluorophore. Also provided is a method for rapid and accurate detection of analytes using the fluorescent single chain antibody construct thereof. Further provided is a diagnostic kit for... Agent: Howrey LLP

20080188008 - Search for cancer markers by a novel screening method: f

20080188009 - Immuno gold lateral flow assay: A chromatographic specific binding assay strip device, comprising: a non-permeable platform strip; a permeable membrane testing strip positioned on top of said non-permeable platform strip, with the testing strip comprising at least one capture reagent site containing a capture reagent for at least one specific analyte, a sample receiving pad... Agent: Jonathan E. Grant

20080188010 - Biosensor substrate: It is an object of the present invention to provide a biosensor substrate that prevents non-specific adsorption and is used for immobilizing a physiologically active substance. The present invention provides a biosensor substrate which comprises an inorganic oxide film and a hydrophilic polymer having a physiologically active substance-immobilizing group on... Agent: Sughrue Mion, PLLC