Chemistry: analytical and immunological testing inventions 05/08

20080124805 - Cytometer having fluid core stream position control: A cytometer having two or more chambers or regions in a containment structure of sheathing fluid that may be used to provide hydrodynamic focusing of another fluid having particles to be observed. The latter fluid may be a core stream which may have its lateral position in a flow or... Agent: Honeywell International Inc.

20080124806 - Fluorescent labeling reagent: A fluorescent labeling reagent of the present invention includes an inorganic fluorescent particle and a material (A) having a material (B) of biological origin adsorbed or bound thereto. The inorganic fluorescent particle is integrated with the material (A) so as to form the reagent of the present invention. The inorganic... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080124807 - Protein tagging reagents: Benzylamine-like reagents for the affinity enrichment and relative quantification of post-translational hydroxylation and nitration of tyrosine and tryptophan in proteins are provided.... Agent: Stinson Morrison Hecker LLP Attn: Patent Group

20080124808 - Crystallization and structure of a plant peptide deformylase: This invention relates to the crystal structure of a plant peptide deformylase polypeptide and methods of using the structure to design compounds that modulate the activity of the polypeptide.... Agent: Buchanan, Ingersoll & Rooney LLP

20080124809 - Method of interaction observation: A method of label-free observing of any interaction between biomolecule and substance immobilized on a metal substrate, characterized in that the substance is immobilized on the metal substrate by a covalent bond through photoreaction.... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20080124810 - Detection of nucleic acid targets using chemically reactive oligonucleotide probes: The present invention provides compositions, apparatuses and methods for detecting one or more nucleic acid targets present in a sample. Methods of the invention include utilizing two or more oligonucleotide probes that reversibly bind a target nucleic acid in close proximity to each other and possess complementary reactive ligation moieties.... Agent: Morgan, Lewis & Bockius, LLP

20080124811 - Human bnp immunospecific antibodies: The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies... Agent: Paul D. Yasger Abbott Laboratories

20080124813 - Bead-based radioimmunoassay: A method of small volume bead-based radioimmunoassay which includes utilization of an immunoassay particle having a solid phase substrate linked to a target particle capture moiety which dissociably captures target particles in an immunoassay sample. Specifically, a bead linked to antibody which competitively dissociably captures target particles and labeled particles... Agent: Cr Miles, P.C. Craig R. Miles

20080124812 - Prevention of leaching of ligands from affinity-based purification systems: In an affinity-type purification, ligands dissociated from the stationary phase that would otherwise leach into the species being purified are captured by a second ligand that is also incorporated into the stationary phase, the second ligand exhibiting an affinity-type interaction with the dissociated first ligand with sufficient specificity to avoid... Agent: Townsend And Townsend And Crew, LLP

20080118982 - Tagged petroleum products and methods of detecting same: Tagged products (including tagged petroleum products) and methods of detecting the same are disclosed. The tagged petroleum products are tagged with a violanthrone, e.g., a substituted violanthrone and/or an isoviolanthrone, e.g., a substituted isoviolanthrone.... Agent: Fish & Richardson P.c.

20080118984 - Biosensing system and related biosensing method: A biosensing system for testing a testing strip to generate a testing result includes: a timing module, for determining a time parameter according to a time point when the testing strip is manufactured; and a testing module, for performing a biochemical operation on the testing strip to generate an original... Agent: Birch Stewart Kolasch & Birch

20080118983 - Methods and devices for rapid and specific detection of multiple proteins: A method is provided for detecting multiple analytes via their interactions with reagents. The analytes are immobilized on an analyte support and are divided into subdivisions by a blotting apparatus. Reagents are applied, each to a specific subdivision of the analyte support and binds to the analytes there.... Agent: Yingjian Wang Hypromatrix, Inc.

20080118985 - Osmotic reaction detector for detecting biological and non-biological reactions: A method and apparatus for measuring the presence or absence of interaction between at least a first and second material of interest by measuring osmotic pressure changes in an osmotic cell. Changes in osmotic pressure are determined by measuring the amount of compression exhibited by a compressible, semi-permeable material positioned... Agent: Fay Sharpe / Xerox - Parc

20080118986 - Methods for amplifying the raman signal of surface enhanced raman scattering nanoparticles: Methods for amplifying the Raman signal of primary SERS nanoparticles are provided. One method generally includes binding secondary SERS particles to the primary SERS nanoparticles after binding of the primary SERS nanoparticles. In another method, secondary SERS nanoparticles are brought in close proximity to the primary SERS nanoparticles, wherein the... Agent: General Electric Company Global Research

20080118987 - Microfluidic device for identification, quantification, and authentication of latent markers: Devices and methods for identification, authentication, and quantification of one or more covert markers in a material are disclosed. A device includes a microfluidic cell, a liquid transfer system, and a detector system and is an integrated unit providing an automated, in-line process for identifying one or more materials containing... Agent: Fish & Richardson P.c.

20080118988 - Method for accessing the contents of a closed collection device: A method for obtaining the contents of a fluid-holding vessel having a cap secured to an open end thereof. The method includes penetrating a surface of the cap with a fluid transfer device and forming one or more air passageways between the penetrated surface of the cap and the fluid... Agent: Gen Probe Incorporated

20080118989 - Method for accessing the contents of a closed collection device: A method for obtaining the contents of a fluid-holding vessel having a cap secured to an open end thereof. The method includes penetrating a surface of the cap with a fluid transfer device and forming one or more air passageways between the penetrated surface of the cap and the fluid... Agent: Gen Probe Incorporated

20080118990 - Assay for lipoproteins using lumiphore k-37: The present invention relates to a method of determining the concentration of total lipoprotein in sample solution. The method comprising the steps of adding to an aliquot of the sample a probe substance, K-37 which binds to lipoproteins in the sample, and which when so bound fluoresces under appropriate excitation.... Agent: Lerner, David, Littenberg, Krumholz & Mentlik

20080118991 - Method for isolating and purifying grass pollen allergens: The invention relates to a method for quickly and effectively isolating and purifying five, namely the group 1, 2, 3, 10 and 13 allergens from grass pollen. The purification of said grass pollen is based on the inventive combination of hydrophobic interaction chromatography, gel filtration and cation exchange chromatography. The... Agent: Millen, White, Zelano & Branigan, P.c.

20080118992 - Method for measuring molecular interactions by laser light scattering (lls): Procedure for the quantitative determination of interactions of ligands with receptors adsorbed on the surface of particles, by direct measure of the scattering of light by Laser Light Scattering (LLS), with the usage of submicrometric polymeric particles with diameter between 5 and 200 nm.... Agent: Young & Thompson

20080113438 - Hematology linearity control composition, system and method of use: A linearity control system includes a series of linearity control compositions, each thereof includes white blood cell analogs and stabilized red blood cells in a suspension medium. The concentration of the white blood cell analogs in the series of control compositions increases from 0.2×103 to 800×103 analogs per microliter, and... Agent: Beckman Coulter, Inc.

20080113439 - Method for predicting catalyst performance: A method of predicting the catalytic performance of a multi-site catalyst comprising reducing a control catalyst of known catalytic performance as a function of temperature, quantifying the different catalyst sites in the control catalyst to determine a ratio of desirable catalyst sites to undesirable catalyst sites, reducing a sample catalyst... Agent: Fina Technology Inc

20080113440 - Method and apparatus for tissue sample processing: Aspects of the present invention relate to laboratory systems for processing tissue samples and specimens within a laboratory. In particular, the present invention relates to a system for automating sample processing, comprising handling and analysis of tissue specimens with laboratory and/or medical diagnostic equipment. In one form the present invention... Agent: Banner & Witcoff, Ltd.

20080113442 - Reagents for arsenic meter: A formulation for preparing water samples for determining arsenic concentration by colorimetry is provided. The chemical reagents in the formulation may be provided as premeasured and premixed tablets or pills. The chemical reagents include sulfamic acid, an oxidizer, and color reagents for selectively forming molybdenum-based color complexes with arsenates and... Agent: Baker Botts L.l.p.

20080113443 - Polypeptide formulations and methods for making, using and characterizing them: Embodiments of the invention include polypeptide formulations and methods for making, using and characterizing them. Embodiment of the invention include stabilized polypeptide formulations, for example stable glucose oxidase formulations that can be used with glucose sensors used in the management of diabetes. Another embodiment of the invention includes methods to... Agent: Attn: William J. Wood Gates & Cooper LLP

20080113444 - Method for detecting oligermization of soluble amyloid beta oligomers: The present invention relates to the assay, analysis, and characterization of soluble amyloid beta oligomers, as well as the characterization of inhibitors of soluble amyloid beta oligomer assembly. In particular, the present invention is a method for detecting assembly of soluble amyloid beta oligomers via a combination of fluorescence resonance... Agent: Jane Massey Licata Licata & Tyrrell P.c.

20080113441 - Isobaric labeling and methods of use thereof: Briefly described, embodiments of this disclosure include method of identifying compounds and the like.... Agent: Thomas, Kayden, Horstemeyer & Risley, LLP

20080113445 - Non-metallic laboratory implement and method of its use: A laboratory implement consisting of a body formed with at least a blade at one end thereof is used for handling biological samples. The blade is provided with photoluminescent qualities, so as to emit visible light when subjected to ultraviolet light. In the method, the implement is positioned in a... Agent: Silber & Fridman

20080113446 - Versatile substrate for spr detection: A substrate for testing a carrier liquid for biomolecules using SPR or other techniques provides a metallic island surrounded by a hydrophobic layer, the islands being a location for the attachment of probe molecules. The hydrophobic layer may also be a dielectric material providing improved sensitivity in SPR imaging.... Agent: Wisconsin Alumni Research Foundation

20080113447 - Flow cytometer and fluidic line assembly with multiple injection needles: A flow cytometer is provided which includes an interrogation flow cell and a plurality of assay fluidic lines extending into the interrogation flow cell. A method of operating such a flow cytometer includes priming the interrogation flow cell with a sheath fluid and injecting different assay fluids into a flow... Agent: Daffer Mcdaniel LLP

20080113448 - Fluorescent carbon nanoparticles: Disclosed are photoluminescent particles. The particles include a core nano-sized particle of carbon and a passivation agent bound to the surface of the nanoparticle. The passivation agent can be, for instance, a polymeric material. The passivation agent can also be derivatized for particular applications. For example, the photoluminescent carbon nanoparticles... Agent: Dority & Manning, P.a.

20080113450 - Method and device for mixing samples on a support: A method for detecting analytes in a liquid is provided in which the liquid is subjected to a mixing treatment on an area of a support which has in particular immobilized reactants, wherein in the mixing treatment the liquid is impinged upon by a stream of gas that sweeps across... Agent: Barnes & Thornburg LLP (roche)

20080113449 - Novel receptors: The invention provides isolated nucleic acid and amino acid sequences of novel receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of the receptors.... Agent: Banner & Witcoff, Ltd.

20080113451 - Method of labeling with use of rare earth fluorescent complex and method of analyzing and detecting: A relatively simple and easy method of laveling in which a sample used in electrophoresis technology is labeled with the use of rare earth fluorescent complex DTBTA-Eu3+ as a labeling agent so as to exhibit a fluorescence intensity being stable without dependence on the intensity of electric field. Further, there... Agent: Wenderoth, Lind & Ponack, L.l.p.

20080113452 - Carrier particle latex for assay reagent and assay reagent: The invention is a carrier particle latex for an assay reagent comprising a carrier particle comprising a copolymer of a polymerizable monomer having a phenyl group and a polymerizable monomer having a phenyl group and a sulfonate, wherein said carrier particle has a surface sulfonic acid group amount of 0.005... Agent: Sughrue Mion, Pllc

20080108141 - Diaminorhodamine derivative: wherein, in the formula (I), R1, R2, R3, and R4 independently represent methyl group or ethyl group; and in the formula (II), R5, R6, R7, and R8 independently represent methyl group or ethyl group and X— represents an anion, and a reagent for measurement of nitric oxide which comprises said... Agent: Greenblum & Bernstein, P.L.C

20080108142 - Visual spill indicator: Composition which includes a dye (101) that changes color when contacted with a suitable amount of an organic substance, in conjunction with a matrix (103), past (102), support (104) or web (104), that indicates visually or photometrically the presence of the organic substance.... Agent: Christopoher John Rudy

20080108143 - Selection of particles in laminar flow: The invention relates to a method for selecting charged particles possessing a predetermined property from a population of a multiplicity of different particles, and also to a device which is suitable for implementing the method.... Agent: Rothwell, Figg, Ernst & Manbeck, P.c.

20080108144 - Method for the rapid analysis of polypeptides: The invention provides improved sample preparation techniques as will as improved methods of analysis of samples. The techniques include a method of preparing a sample of MALDI-TOF analysis comprising applying a material having a liquid component to a carrier, removing at least a portion of the liquid component, and applying... Agent: Dunlap Codding & Rogers, P.c.

20080108145 - Genes associated with osteoarthritis: A method of screening a small molecule compound for use in treating osteoarthritis, comprising screening a test compound against a target selected from the group consisting of the gene products encoded by ADAM15, ADAM23, ADAM30, C22ORF18, CACNB2, CTRL, LCAT, GPR75, MAOB, OPRL1, GPR8, PKD2L1, PTH, RAB3-GAP150, RARG, SHH, TBXA2R, TNK2,... Agent: Glaxosmithkline Corporate Intellectual Property

20080108146 - Flow cytometers: A calibration method for a flow cytometer with a multichannel detector module. During calibration, the fluorescence intensity data values for the different detector channels are used to calculate normalization factors needed to adjust subsequent data collected by each of the channels. By using a multichannel detector module, the results from... Agent: Foley And Lardner LLP Suite 500

20080108147 - Reduction of non-specific binding in immunoassays: Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample wherein one of the reagents for conducting the binding assay is an antibody reagent. The methods comprise treating the antibody reagent at a pH of about 2.0 to... Agent: Dade Behring Inc. Legal Department

20080108148 - Human salty taste receptor and methods of modulating salty taste perception: Methods for identifying modulators of the epithelial sodium ion channel and for identifying modulators of salty taste perception are described. Also featured are isolated human salty taste receptors, artificial lipid bilayers comprising an epithelial sodium ion channels, and kits for practicing the claimed methods.... Agent: Woodcock Washburn LLP

20080108149 - Solid-phase mediated synthesis of molecular microarrays: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived methods and electrochemically generated reagents. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides, polymers joined by peptide bonds, nucleic acids, and polymers... Agent: Intel/blakely

20080108150 - Systems and methods for molecular recognition: Acoustic wave devices coated with a biolayer are described for the detection target bio-molecules. The acoustic wave device is connected in an oscillator circuit, and the frequency shift Δf resulting from a biomolecular event is recorded. Further described are the use of Rayleigh wave surface acoustic wave devices for vapor... Agent: Perkins Coie LLP

20080108151 - Process for (a) separating biological ligands from dilute solutions and (b) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughout: Superparamagnetic (“SPM”) subunits of 1-30 nm average mean diameter (e.g. ferro fluid) subparticles are treated with a magnetically noninterfering substance capable of coating and covering them (e.g, BSA) and they spontaneously form agglomerates of about 100 nm to about 450 nm or higher average mean diameter and are then used... Agent: Foley Hoag, LLP Patent Group (w/isa)

20080108152 - Methods for characterizing glycoproteins and generating antibodies for same: The invention provides methods for generating an antibody specific for the deglycosylated form of a glycopolypeptide using a peptide corresponding to an N-linked glycosylation site of a glycopolypeptide. The invention additionally provides methods for generating an antibody specific for a glycopolypeptide using a peptide corresponding to amino acids adjacent to... Agent: Mcdermott, Will & Emery

20080102525 - Novel standard reference solutions: Standard reference materials and related methods are described for quality testing and calibration of instruments used for the qualitative and quantitative determination of hemoglobin and glycated hemoglobin as well as other analytes of interest in animal tissue samples. The reference solutions of the disclosure utilize a synthetic cruor in combination... Agent: Mcdermott Will & Emery LLP

20080102528 - Automatic biochemical analyzing method and apparatus: An automatic biochemical analyzing method is described, in which a row of reaction containers is cyclically arrayed such that an operating cycle is formed that is defined between dispensing the preceding sample and the sequent sample. In each cycle, the reaction containers are transferred so as to motivate at least... Agent: Beyer Weaver LLP

20080102529 - Process for evaluating a refinery feedstock: The invention provides a process for evaluating the effect of a refinery feedstock on a refinery process, said process comprising (i) providing a refinery feedstock; (ii) treating said refinery feedstock to produce a plurality of fractions each representative of the typical feedstock for the refinery process of interest, said plurality... Agent: Nixon & Vanderhye, PC

20080102531 - Fingerprint analysis for a plurality of oligonucleotides: The invention provides a method for evaluating the accuracy of an oligonucleotide sample, specifically a sample containing a variety of oligonucleotides of potentially varying size and sequence. The method provides a fingerprint that can be used to evaluate the accuracy of a multi-oligonucleotide sample whether or not the sample contains... Agent: John Petravich Integrated Dna Technologies, Inc.

20080102526 - Reagent, reagent kit and analyzing method: A method for analyzing platelet is described. In the method, a measurement sample is prepared by mixing a sample and a dye for staining platelet. The dye is selected from the group consisting of Capri blue, Nile blue and brilliant cresyl blue. By irradiating cells in the measurement sample with... Agent: Sughrue Mion, PLLC

20080102527 - Method for introducing a fluid into a reaction receptacle contained within a temperature-controlled environment: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing... Agent: Rothwell, Figg, Ernst & Manbeck, P.C.

20080102530 - Methods to radiolabel natural organic matter by reduction with hydrogen labeled reducing agents: Methods to radiolabel natural organic matter by reduction with a hydrogen labeled reducing agent, and compositions, are provided.... Agent: Dorsey & Whitney, LLP Intellectual Property Department

20080102532 - Handheld microcantilever-based sensor for detecting tobacco-specific nitrosamines: A method and system for detecting tobacco-specific nitrosamines. The method includes exposing at least one microcantilever beam to a medium, which may contain tobacco-specific nitrosamines, and measuring a deflection of the microcantilever beam, wherein the deflection indicates a presence of tobacco-specific nitrosamines in the medium. The at least one microcantilever... Agent: Buchanan, Ingersoll & Rooney PC

20080102533 - Apparatus and method for measuring specific heat using flash: The present invention relates to an apparatus and method for measuring specific heat using flash. To this end, the specific heat measurement apparatus includes sample fixing means for fixing a sample 50 so that each of both surfaces 52, 55 of the sample 50 is partially exposed, flash irradiation means... Agent: Patterson, Thuente, Skaar & Christensen, P.A.

20080102534 - Unsaturated dipyrromethene-boron borocarbons: The invention relates to unsaturated dipyrromethene-boron borocarbons of formula (I) and the use thereof for fluorescence or electroluminescent analysis. The fluorescent properties are provided by the central ring of six atoms comprising the —N—B—N— sequence, R1 to R7 permitting the modification of the compound properties (fluorescence emission wavelength, quantitative fluorescent... Agent: Young & Thompson

20080102535 - Measuring thyroxine levels from dried blood samples using mass spectrometry: Measuring thyroxine levels from dried blood samples using mass spectrometry. A test sample is provided that was obtained by treating a dried blood sample with an extraction solution. The test sample also includes an isotopically enriched thyroxine standard. The test sample is scanned using a mass spectrometer to produce one... Agent: Choate, Hall & Stewart LLP

20080102536 - Method of manufacturing an analytical sample and method of analyzing an analytical sample: A method of manufacturing an analytical sample by a secondary ion mass spectrometry method is provided, which comprises a step of forming a separation layer over a substrate, a step of forming one of a thin film and a thin-film stack body to be analyzed over the separation layer, a... Agent: Eric Robinson

20080102537 - Method of detecting analytes in a microfluidic sample and a system for performing the same: A method of detecting analytes in a microfluidic sample includes introducing at least one type of analyte, at least one type of carrier particle, and a fluid into a mixing chamber of a system. The at least one type of analyte binds to a site on the at least one... Agent: Hewlett Packard Company