Chemistry: analytical and immunological testing inventions 04/08

20080096281 - Cyanide sensing compounds and uses thereof: The present invention relates to a cyanide detection method using fluorescence and cyanide sensitive boronic acid containing fluorophores, wherein a change in a measured fluorescent property correlates to the concentration of the cyanide compound in a biological or environmental test sample.... Agent: Moore & Van Allen PLLC

20080096282 - Spectrophotometic analysis of plasma in a closed-container: The present invention provides a method of analyzing plasma from a sample of whole blood comprising a) obtaining a sample of whole blood from a subject in a container, the container comprising a first end and a second end, the first end of the container for receiving a sample of... Agent: Quarles & Brady LLP

20080096280 - Method of assaying the antioxidant activity of oils: A method of assaying the antioxidant activity of a range of plant, animal or synthetic oils and other similar substances in a liquid phase. The method consists in forming an oil-in-water emulsion with a surfactant, adding an ethene generator substrate and an oxidative peroxyl radical solution and measuring the ethene... Agent: D. Peter Hochberg Co. L.p.a.

20080096283 - Methods for detection of breast cancer: The invention relates to a simple screening test for neoplasia, a precancerous condition, or cancer of the breast. A method is described whereby a breast cancer marker is detected in breast fluid. In a particular embodiment, the method involves treating samples of breast fluids with an aldehyde detecting reagent without... Agent: Merchant & Gould PC

20080096284 - Protein separation and analysis: The present invention relates to multi-phase protein separation methods capable of resolving and characterizing large numbers of cellular proteins, including methods for efficiently facilitating the transfer of protein samples between separation phases. In particular, the present invention provides systems and methods for the differential display of protein samples from multiple... Agent: Casimir Jones, S.c.

20080096285 - Method for automatic determination of sample: A method of determining a kind of a sample, in a method for analyzing a substance by the steps of supplying the sample to be analyzed to a reaction system by a supplying means comprising a transparent region composed of a transparent material, reacting a reagent for detecting the substance... Agent: Heslin Rothenberg Farley & Mesiti PC

20080096286 - Biopolymer marker indicative of disease state having a molecular weight of 1348 daltons: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their... Agent: Mchale & Slavin, P.A.

20080096287 - Nanoscale moiety placement methods: Methods and structures for placing nanoscale moieties on substrates are provided.... Agent: Agilent Technologies, Inc. Legal Department, Dl429

20080096288 - Membrane-based assay devices: A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes... Agent: Dority & Manning, P.A.

20080096289 - Core-shell nanoparticles for detection based on sers: A nanoparticle having a self assembly monolayer of molecules as a shell on the nanoparticle. The monolayer may include organic molecules working as surface enhanced Raman spectroscopy (SERS) reporters. Also, the core shell may include at least a receptor, and/or the like, to ensure that a target analyte can be... Agent: Honeywell International Inc.

20080090296 - Method for the determination of the oxidative stability of a lubricating fluid: P

20080090297 - Methods for determining the metal bioavailability of metal sources: The invention provides methods for determining the relative metal bioavailability of a metal source in an animal or group of animals. The method may be utilized to compare the relative metal bioavailability between different metal sources and it may be used to determine the relative nutritional status of a metal... Agent: Polsinelli Shalton Flanigan Suelthaus PC

20080090298 - Method and system for identification of protein-protein interaction: A method for the characterization of protein-protein interactions based on diagonal mass spectrometry is provided. Proteomic samples containing interacting proteins are chemically crosslinked either in vivo or in vitro. After a high resolution chromatographic separation, crosslinked interacting proteins are introduced directly into a mass spectrometer. During the data acquisition, the... Agent: Agilent Technologies Inc.

20080090299 - Method and system for identification of protein-protein interactions: A method for rapid detection and possibly identification of protein complexes is disclosed. The method utilizes a two stage high resolution chromatographic analysis and a reversible crosslinker to detect and identify protein complexes. The identification of protein complexes may be further improved by mass spectrometry analysis of chromatographic fractions containing... Agent: Agilent Technologies Inc.

20080090301 - Method to detect adulterated specimens: The invention is a method to detect adulterated specimens submitted for substance abuse. It is concerned with testing a sample of the submitted urine, and in a parallel test analyze a sample of the submitted urine to which has been added known amount of the suspected substance. A control artificial... Agent: William M. Selenke

20080090295 - Method and device for preparing an analyte for analysis by mass spectrometry: The invention provides methods and apparatus for automated sample preparation for MALDI-TOF MS using columns in combination with a liquid handling system. The samples are typically biological such as serum or urine. The columns typically include a bed of media positioned within a modified pipette tip. In some embodiments, the... Agent: Phynexus, Inc.

20080090300 - Detection of gleevec resistant mutations: The present invention relates to isolated polypeptides which comprise an amino acid sequence consisting of a mutated functional Abl kinase domain, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for... Agent: Klarquist Sparkman, LLP

20080090302 - Method for prediction of high frequency reciprocating rig wear scar diameter for hydrocarbon mixtures: A method is disclosed for predicting the High Frequency Reciprocating Rig (HFRR) wear scar diameter for a hydrocarbon mixture using an HFRR wear scar diameter prediction equation which predicts the HFRR wear scar diameter based on the mid-infrared spectroscopy test results for such hydrocarbon mixture. Such predicted HFRR wear scar... Agent: Conocophillips Company - I.p.legal

20080090305 - Device for detection of molecules in biological fluids: Disclosed is a test device and a method for qualitatively and/or quantitatively measuring the concentration of an analyte in a biological fluid sample. The test device includes a housing defining a sample port, a test well containing a stirrer and a conjugate, and a test strip disposed within the housing.... Agent: Fay Sharpe LLP

20080090304 - Diagnosis and monitoring of chronic renal disease using ngal: A method of assessing the ongoing kidney status of a mammal afflicted with or at risk of developing chronic renal injury or disease, including chronic renal failure (CRF) by detecting the quantity of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in urine, serum or plasma samples at discrete time periods, as well as... Agent: Hasse & Nesbitt LLC

20080090303 - Methods and reagents for detecting bioactive lipids: Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic acid or sphingosine-1-phosphate)... Agent: Biotechnology Law Group C/o Portfolioip

20080090306 - Method for immobilizing biomolecules: An object of the present invention is to provide a method for preventing the generation of negative signals because of dissociation of a ligand from a surface and improving the precision of signals indicating binding between a ligand and an analyte. The present invention provides a method for immobilizing a... Agent: Sughrue Mion, PLLC

20080085559 - Micro-pixelated active-matrix fluid-assay performance: A method of performing a fluid-material assay employing a device including at least one active pixel having a sensor with an assay site functionalized for selected fluid-assay material. The method includes exposing the pixel's sensor assay site to such material, and in conjunction with such exposing, and employing the active... Agent: Robert Varitz

20080085562 - Detection of gadolinium chelates: A method for determining the presence or amount of a gadolinium chelate in a biological sample. The method includes contacting a biological sample with a dye selected from arsenazo III or chlorophosphonazo at low pH, and measuring the absorbance of the sample, thereby determining the presence or amount of gadolinium... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080085563 - Detection of gadolinium chelates: A method for determining the presence or amount of a gadolinium chelate in a biological sample. The method includes contacting a biological sample with a dye selected from arsenazo III or chlorophosphonazo at low pH, and measuring the absorbance of the sample, thereby determining the presence or amount of gadolinium... Agent: Mcdonnell Boehnen Hulbert & Berghoff LLP

20080085564 - Micro-pixelated fluid-assay structure with on-board addressable, pixel-specific functionalization: A digitally-addressable, pixelated, DNA fluid-assay, active-matrix micro-structure formed, utilizing low-temperature TFT and Si technology, on a substrate preferably made of glass or plastic, and including at least one pixel which is defined by (a) an addressable pixel site, (b) a sensor home structure disposed within that site for receiving and... Agent: Robert Varitz

20080085560 - Lysing reagent for simultaneous enumeration of different types of blood cells in a blood sample: A combined diluent and lysing reagent for simultaneously counting or analysis of various blood cells such as thrombocytes, leukocytes and leukocyte subpopulations, as well as analysis of hemoglobin. The reagent comprises a hemoglobin stabilizing/methemoglobin ligand compound selected from the group consisting of imidazole, imidazole derivatives, and combinations thereof, at least... Agent: Volentine & Whitt Pllc

20080085561 - Biosensor and blood component analytical method: According to the biosensor and the blood component analytical method of the present invention, in a biosensor that is made of a single layer or plural layers of a porous material as shown in FIG. 1, having a reagent holding part and utilizing chromatography, a cell shrinkage reagent is carried... Agent: Marjama Muldoon Blasiak & Sullivan LLP

20080085565 - Method of reading encoded particles: Microparticles 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 having a plurality of colocated pitches Λ which represent a unique identification digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely... Agent: The Small Patent Law Group LLP

20080085566 - Emissive compositions with internal standard and related techniques: The present invention provides materials, devices, and methods related to determination of an analyte. In some embodiments, an analyte may be determined by monitoring, for example, a change in an optical signal of a luminescent material (e.g., particle) upon exposure to an analyte. The present invention may be particularly advantageous... Agent: Wolf Greenfield & Sacks, P.c.

20080081374 - Coloration agent for carbonyl sulfide, detecting means and fuel cell system: Provided are a coloration agent for carbonyl sulfide which contains a metal oxide, and at least one metal component selected from among a cerium component, a silver component, a copper component, a nickel component, and an iron component, the metal component being supported on the metal oxide, or which contains... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080081375 - Metabolite detection using magnetic resonance: Methods using magnetic resonance, such as nuclear magnetic resonance (NMR) spectroscopy or magnetic resonance imaging (MRI), are provided for detecting metabolites in a sample. The methods are useful for the diagnosis or prognosis of a disease such as cancer and can also be used to determine or monitor a treatment... Agent: John S. Pratt, Esq Kilpatrick Stockton, LLP

20080081376 - Mercury sensor using anisotropic gold nanoparticles and related water remediation: A method of sensing Hg and related Hg sensing system for fluid samples includes the steps of providing a sensing solution including a plurality of anisotropic Au nanoparticles, and contacting a water sample or an air sample suspected of containing Hg or a vapor stream derived from the water sample... Agent: Darby & Darby P.C.

20080081377 - Nucleic acid detection method and examination kit: Nucleic acid detection method for detecting a target nucleic acid in an analyte solution, including the steps of preparing a mixed solution by mixing, labeled nucleic acid probes in which nucleic acid probes to be associated with the target nucleic acid are immobilized on microcarriers, the analyte solution; and a... Agent: Fitzpatrick Cella Harper & Scinto

20080081378 - Mechanical device for mixing a fluid sample with a treatment solution: A device for preparing a fluid sample for use in a fluid analyte meter, including: a first portion, comprising: a septum piercing projection, a capillary channel, and a vent on an outer surface of the first portion; and a second portion, comprising: a treatment solution chamber, and a septum sealing... Agent: Bayer Lerner, David, Littenberg, Krumholz & Mentlik, LLP

20080081379 - Homogeneous double receptor agglutination assay for immunosuppressant drugs: A homogeneous, non-competitive, double receptor agglutination assay for measuring immunosuppressant drugs is described. The assay employs at least two receptors wherein each receptor is specific for a separate binding site on the drug and wherein each receptor is bound to a detection particle. The immunosuppressant drug binds to the receptors... Agent: Roche Diagnostics Operations Inc.