Chemistry: analytical and immunological testing inventions 02/08

20080050827 - Derivatization-enhanced analysis of amino acids and peptides: The present invention provides compositions and methods for enhanced detection and quantification of amino acids by derivatization. Also provided are compositions and methods for enhanced detection and quantification of peptides by derivatization.... Agent: Brinks Hofer Gilson & Lione

20080050828 - Multifunctional nanocrystals: Multifunctional nanocomposites are provided including a core of either a magnetic material or an inorganic semiconductor, and, a shell of either a magnetic material or an inorganic semiconductor, wherein the core and the shell are of differing materials, such multifunctional nanocomposites having multifunctional properties including magnetic properties from the magnetic... Agent: Los Alamos National Security, LLC

20080050830 - Detecting multiple types of leukocytes: Methods, systems, and apparatus for detecting multiple types of leukocytes in a blood sample material. A fluid or gas sample may pass through a sieve-based detection system of a cartridge. Detection and analysis techniques may be applied to determine the relative distribution of multiple types of white blood cells in... Agent: Fulbright & Jaworski L.L.P.

20080050831 - Systems and methods for characterization of molecules: The present invention generally provides systems and methods for the detection, identification, or characterization of differences between properties or behavior of corresponding species in two or more mixtures comprised of molecules, including biomolecules and/or molecules able to interact with biomolecules, using techniques such as partitioning. The experimental conditions established as... Agent: Wolf Greenfield & Sacks, P.C.

20080050829 - Use of mass spectrometry to detect sepsis: Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not... Agent: Becton, Dickinson And Company Attn: David W. Highet

20080050833 - Ionizable isotopic labeling reagents for relative quantification by mass spectrometry: Relative quantification of metabolites by Electrospray Ionization Mass Spectrometry (ESI-MS) requiring a mechanism for simultaneous analysis of multiple analytes in two or more samples. Labeling reagents that are reactive to particular compound classes and differ only in their isotopic kit facilitating relative quantification and providing tangible evidence for the existence... Agent: Quarles & Brady LLP

20080050832 - Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes: The present invention relates to methods and compositions for prognosis in severe immune response syndrome. Values calculated from CCL23, CRP, and NGAL assay measurements are used to indicate the risk of sepsis progression and/or to identify patients at high risk from infections.... Agent: Foley & Lardner LLP

20080050834 - Protein crystallization droplet actuator, system and method: Protein crystallization droplet actuators, systems and methods are provided. According to one embodiment, a droplet actuator for providing an array of crystallization conditions is provided and includes: (a) two or more processing reservoirs; (b) two or more dispensing reservoirs collectively comprising two or more crystallization reagents; and (c) a port... Agent: Ward And Smith, P.A.

20080050835 - Adh7 nucleic acids: Isolated human nucleic acids implicated in Parkinson's disease and the uses thereof, such as in diagnostic and prognostic methods and in pharmaceutical preparations.... Agent: Young & Thompson

20080050836 - Biomarkers for screening, predicting, and monitoring benign prostate hyperplasia: Gene expression data are analyzed using learning machines such as support vector machines (SVM) and ridge regression classifiers to rank genes according to their ability to distinguish between BPH (benign prostatic hyperplasia) and all other conditions. Results are provided showing the correlation of results obtained using data from two independent... Agent: Procopio, Cory, Hargreaves & Savitch LLP

20080050837 - Lmna gene and its involvement in hutchinson-gilford progeria syndrome (hgps) and arteriosclerosis: Disclosed herein are point mutations in the LMNA gene that cause HGPS. These mutations activate a cryptic splice site within the LMNA gene, which leads to deletion of part of exon 11 and generation of a mutant Lamin A protein product that is 50 amino acids shorter than the normal... Agent: Klarquist Sparkman, LLP

20080050838 - Methods for matrix cleanup and analysis of drugs and metabolites in biological matrices: The invention is directed to the use of weak anion exchange (WAX) materials for trapping of negative and zwitterionic interfaces from biological matrices, and then reduction of the biological matrix effect in the quantitative analysis process of basic and neutral compounds present in the matrix. The sample preparation process includes... Agent: Yuhui Yang

20080050839 - Apparatus and method for detecting lung cancer using exhaled breath: The present invention is an apparatus and method for detecting lung cancer. The apparatus is composed of a breath capture device including a colorimetric sensor array with a plurality of chemoresponsive dyes deposited thereon in a predetermined pattern combination, wherein the dyes produce a distinct and direct spectral, transmission or... Agent: Jane Massey Licata Licata & Tyrrell P.C.

20080050840 - Novel protein kinase molecules and uses therefor: The invention provides isolated nucleic acids molecules, designated CSAPK nucleic acid molecules, which encode novel protein kinases. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CSAPK nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a... Agent: Millennium Pharmaceuticals, Inc.

20080050841 - Peptides immunoreactive with autoantibodies from patients suffering from rheumatoid arthritis: The invention relates to a peptide derived from an antigen recognized by autoantibodies, which peptide is reactive with autoimmune antibodies from a patient suffering from rheumatoid arthritis. The peptide according to the invention possesses a modified arginine residue. The invention also relates to antibodies against the peptide and a method... Agent: Morrison & Foerster LLP

20080050842 - Method of visualization and quanitification of biopolymer molecules immobilized on solid support: A method and kit are provided for visualization of a latent pattern of molecular structures on a substrate surface. The method is comprised of exposing the substrate to a solution of nano-particles or to a powder of nano-particles. A detectable change is brought about as a result of non-specific binding... Agent: Luedeka, Neely & Graham, P.C.

20080050843 - Methamphetamine derivatives and conjugates for immunoassay: m

20080044908 - Method of normalizing surface tension of a sample fluid: A method of normalizing surface tension of a sample fluid on a clinical analyzer is disclosed. The method comprises aspirating a portion of a sample fluid into a metering tip, the metering tip having a lower end through which the sample fluid is aspirated and an upper end; sealing the... Agent: Philip S. Johnson Johnson & Johnson

20080044910 - Chemical sensors comprising fluorescent conjugated polymers as sensitive materials, and their use in the detection or assaying of nitro compounds: m

20080044909 - Method for detecting trace explosives using photoluminescence: A method for detecting trace explosives which includes obtaining a sample believed to contain explosives residue and contacting the sample and a carrier container containing the sample with a reagent. The sample and the carrier is illuminated by an appropriate laser or other light source while it is contained within... Agent: Fulbright And Jaworski LLP

20080044913 - Novel 8-hydroxyquinoline acetamide compound, 8-hydroxy quinoline thioamide compound and use thereof: m

20080044911 - Nano-chem-fet based biosensors: Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising functionalized and/or non-functionalized nanowires are provided. Nanosensors are used for detection in cellular fragmentation, multiple concentration analysis, glucose detection, and intracellular analysis.... Agent: Nanosys Inc.

20080044912 - Blood coagulation analyzer and blood coagulation analyzing method: A blood coagulation analyzer and analyzing method perform following: (a) preparing a measurement specimen by dispensing a blood specimen and a reagent into a reaction container; (b) emitting light of a plurality of wavelengths to the measurement specimen in the reaction container, the wavelengths comprising a first wavelength for use... Agent: Sughrue Mion, PLLC

20080044914 - Protein crystallization screening and optimization droplet actuators, systems and methods: Protein crystallization screening and optimization droplet actuators, systems and methods are provided. According to one embodiment, a screening droplet actuator is provided and includes: (a) a port for introduction of one or more crystallization reagents and/or one or more protein solutions; and (b) a substrate including: (i) an array of... Agent: Ward And Smith, P.A.

20080044915 - Simultaneous sequence analysis of amino- and carboxy-termini: The present invention relates to a new method for identifying polypeptides by deducing the amino acid sequence of the carboxy and amino termini by a mass spectrometer analysis. The method comprises the steps of dissociating highly charged peptide precursor ions (e.g., z>4) using electron transfer dissociation inducing anions followed by... Agent: Barnes & Thornburg LLP

20080044919 - Analyte detection using time-resolved photon counting fluorescence: Samples are exposed to a fluorescent probe that binds to a known target analyte. Unbound probe is removed and the sample is exposed to a pulsed laser light of preferred wavelength, where the laser light is split into background and sample beams, which are separately measured by two photomultiplier tubes... Agent: Richard D Zimmerman Chance Ruttenberg & Freedman

20080044916 - Computational selection of probes for localizing chromosome breakpoints: The present invention provides a novel method for selecting genomic hybridization probes. The method generally includes the step of selecting a genomic interval of interest, identifying at least one potential hybridization probe that has known coordinates within the interval of interest, applying a numerical method to sample the identified probe(s)... Agent: Erickson & Kleypas, L.L.C.

20080044918 - Discrimination method of target base in dna, and allele specific primer used in the method of the same: An object of the present invention is to provide an allele specific primer which is accompanied by less possibility of the false positive and enables definite discrimination when a base immediately adjacent to on the 3′ side of a target SNP base is G, while a base adjacent with one... Agent: Mcdermott Will & Emery LLP

20080044920 - Polymorphism detection: The present invention generally provides a rapid efficient method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods of the present invention employ arrays of oligonucleotide probes that are complementary to target nucleic acids which correspond to the marker sequences of an... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20080044921 - Primers used in novel gene amplification method: A primer for amplifying a target nucleic acid sequence, comprises: a sequence region (a) complementary to a sequence region (a′) in the target nucleic acid sequence; and a sequence region (b) having a sequence complementary to a partial sequence of the sequence region (a), in this order from a 3′... Agent: Birch Stewart Kolasch & Birch

20080044917 - Rapid induction of alzheimer's amyloid plaque formation by sulfated glycosaminoglycans: A method of induction of amyloid plaques includes immobilizing a quantity of a selected sulfated glycosaminoglycan (SGAG) on a selected medium and adding to the immobilized SGAG on the medium a quantity of dissolved low fibrillar Aβ 1-40 (LFAβ). The LFAβ is added preferably in a Aβ:SGAG w/w ratio of... Agent: Proteotech, Inc.

20080044922 - System and method of compensating for system delay in analyte analyzation: A system configured to determine information related to one or more gaseous analytes in a body of gas comprises a luminescable material, one or more emitters, one or more photosensitive detectors, and a processor. The emitters emit amplitude modulated electromagnetic radiation onto the luminescable medium in communication with a body... Agent: Michael W. Haas Respironics, Inc.

20080044923 - Lanthanide complexes preparation and uses thereof: The complex consists of an Ln ion and a ligand R2-C(X-R1)(R3)-NR4R5. R1 is a functional group, X is a single bond or a hydrocarbon-based chain consisting of at least one alkylene or alkenylene group optionally comprising at least one hetero atom or an arylene. R2 is an anionic group A2... Agent: Buchanan Ingersoll Burns, Doane, Swecker & Mathis

20080044924 - Water quality evaluation method and substrate contacting apparatus used: A water quality evaluation method capable of evaluating quality of water to be evaluated with high precision and a substrate contacting apparatus used in the water quality evaluation method are provided. The substrate contacting apparatus 10 has a sealing performance keeping the interior at a vacuum degree lower than or... Agent: J C Patents, Inc.

20080044925 - Biomaterial construct, its producing method, biomaterial support, target material purifying method, affinity chromatography container, separation chip, analyzing method and analyzing separator for target material, biomaterial complex, and its support, sen: A biomaterial structure containing a larger amount of biomaterial than the conventional art with maintaining the reactivity of the biomaterial is provided by linking particulate lumps in which the biomaterial is bound with a compound capable of binding to the biomaterial, wherein the particle diameter of the particulate lumps is... Agent: Oblon, Spivak, Mcclelland Maier & Neustadt, P.C.

20080044926 - Reagent for assaying antigen and method of assaying antigen: It is intended to provide a reagent and an assay method whereby an antigen can be conveniently and accurately assayed without resorting to any special antibody. Using two or more carriers having different particle sizes, a carrier having a smaller particle size is sensitized with at least one monoclonal antibody,... Agent: Young & Thompson

20080044927 - Medical test strip: A test strip comprises a substrate having a long and narrow rectangular shape and the substrate having no hole thereon; a first sample-collection pad adhered to one side of the substrate, the first sample-collection pad having a side notch; the notch and the substrate being formed with a blood sample... Agent: Cheng Ho Lien

20080044928 - Method for the preparation of ready-to-use support for rapid enzyme-linked immunosorbent assay (elisa): The present invention provides a method for the preparation of ready-to-use solid support for ELISA for rapid identification and quantitative estimation of protein/antigen in the test samples, and performances of the assay itself. The invention also provides for a quick, accurate and stable estimation of protein/antigen in the test samples.... Agent: Howrey LLP

20080044929 - Diluent, methods of manufacturing and use: The use of diluent to reduce non-specific,drug binding (NSB) provides a simple, flexible and biocompatible way to reduce chemical entity (such as drugs, drug candidates and other small molecules) NSB so that bioassay results may more closely predict the behavior of these compounds in vitro. Additionally, the use of diluent... Agent: Millipore Corporation

20080038827 - Merge stop gate for an automated laboratory sample handling worksystem: A method for replacing a first sample carried on a moving secondary conveyor onto a moving primary conveyor at a potential interference point while the primary conveyor is transporting a second sample... Agent: Dade Behring Inc. Legal Department

20080038826 - Synthetic iron oxides and their use as an indicator of reduction in soils (iris): The present invention present invention relates to improved IRIS Fe oxide paint compositions, to the dried (or cured) residue of such paints, and to devices upon which such paint compositions have been applied (IRIS devices) used to assess reducing conditions in soils, especially wetland soils. The improved IRIS Fe oxide... Agent: Edell, Shapiro & Finnan, LLC

20080038828 - Protocol for monitoring direct thrombin inhibition: A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis parameters. The measured blood hemostasis parameters permit evaluation of hemostasis therapies including anticoagulation therapies such... Agent: Marshall, Gerstein & Borun LLP

20080038829 - Process for the determination of lipoproteins in body fluids: The invention describes a process for the determination of the concentration distribution and size distribution of lipoprotein classes in body fluids, e.g. blood. For this purpose, NMR spectra of a sample to be analysed are measured by magnetic field gradient intensities and temperatures under different diffusion-weighted measuring conditions selected according... Agent: Cohen, Pontani, Lieberman & Pavane

20080038830 - Nano-particle biochip substrates: The present invention relates to a nano-particle biochip substrate comprising a substrate having attached thereto (bearing), on or in a surface, nano-particles having a cross sectional diameter of from about 0.1 nm. to about 50 nm. and useful to immobilize one or more moieties of interest.... Agent: Wolf Greenfield & Sacks, P.C.

20080038831 - Il-23p40 specific immunoglobulin derived proteins, compositions, epitopes, methods and uses: An anti-IL-23 specific human Ig derived protein, isolated nucleic acids that encode at least one anti-IL-23 Ig derived protein, vectors, host cells, transgenic animals or plants, and methods of making and using thereof are useful as therapeutic and diagnostic compositions, methods and devices. The anti-IL-23 Ig derived protein preferably binds... Agent: Philip S. Johnson Johnson & Johnson

20080038832 - Method for producing molecularly imprinted polymers for the recognition of target molecules: The present invention relates to a method of preparing a molecularly imprinted polymer (MIP), which are used for the recognition of target molecules comprising: co-polymerising at least one functional monomer and at least one cross-linking monomer in the presence of at least one template, wherein oxyanions are used as template... Agent: Schwegman, Lundberg & Woessner, P.A.

20080038833 - Manufacturing execution system for validation, quality and risk assessment and monitoring of pharmaceutical manufacturing processes: Manufacturing execution systems relating to methods, systems, and software program for validation of pharmaceutical manufacturing processes and quality assurance process are described and disclosed herein. Consequently, the methods provide a means to perform validation on an integrated level whereby the quality control unit can ensure data and product integrity and... Agent: Shane M. Popp Smp Logic Systems

20080038834 - Method and device for processing a biological fluid for analyte determination: The present invention refers to a method of processing a biological fluid which comprises cellular components by heat treatment. The method is particularly useful for preparing biological samples for analyte detection. Further, the invention refers to a processed biological fluid comprising substantially quantitatively disintegrated cellular components.... Agent: Arent Fox LLP

20080038835 - Reference member for fluorescence measurements, and method for the production thereof: Disclosed is a reference member for fluorescence measurements, comprising a fluorescent layer (2) by means of which fluorescent radiation is emitted during optical irradiation and at least two fields that are provided with one respective attenuating layer (17 to 29). Said attenuating layer (17 to 29) is located above and/or... Agent: Jacobson Holman PLLC

20080038836 - Automated high volume slide staining system: An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations.... Agent: Ventana Medical Systems, Inc. Attention: Legal Department

20080038837 - Chemical treatment cartridge and method of using same: There are provided a chemical treatment cartridge capable of easily executing a process for separating constituents from each other, and a method of using the same. The chemical treatment cartridge for transferring liquids contained therein due to deformation occurring thereto upon application of an external force thereto, thereby causing chemical... Agent: Westerman, Hattori, Daniels & Adrian, LLP

20080038838 - Dioxin-binding material and method of detecting or quantifying dioxin: A principal object of the present invention is to provide low-cost techniques for readily detecting or quantifying dioxins using substances which are inexpensive and can be easily produced, and extracting dioxins using such substances. Dioxin binding peptides of the present invention are highly selective to dioxins, and are therefore capable... Agent: Fitch, Even, Tabin & Flannery

20080038841 - Biosensor: p

20080038839 - Fluid delivery system and method: A method and apparatus for delivering one or more fluids. Fluids may be delivered sequentially from a common vessel to a chemical, biological or biochemical process.... Agent: Wolf Greenfield & Sacks, P.C.

20080038840 - Fluorescent method and compounds to monitor protein-lipid binding: The invention refers to compounds according to formula (I), wherein R1 is independently in position 2′, 3′, or in both positions of the A ring and is hydroxyl, linear or branched -0-alkyl, wherein the alkyl group has 1-12 carbon atoms, preferably 3-8, more preferably 4 carbon —O-(alkyl)COOH wherein the alkyl... Agent: Connolly Bove Lodge & Hutz, LLP

20080038842 - Slitrk1 mutations associated with disorders in the ocd spectrum: The present invention provides compositions and methods directed to the use of SLITRK1 (slit and trk like 1) mutations to identify, diagnose, and treat disorders in the obsessive-compulsive disorder spectrum. Specifically, the present invention provides methods of identifying a subject having an increased risk of developing a disorder in the... Agent: Myers Bigel Sibley & Sajovec

20080038843 - Method of diagnosing celiac disease: The present invention provides materials and methods to diagnose celiac disease. In some embodiments, the present invention provides a method of diagnosing celiac disease by measuring the serum zonulin level of a subject.... Agent: Connolly Bove Lodge Hutz, LLP (for Alba Therapeutics)

20080038844 - Method of analyzing nucleic acids using an array of encoded beads: A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates;... Agent: Eric P. Mirabez

20080038845 - Assay by osmotically induced separation and concentration of high-molecular detectable substances and a fluid microsystem for carrying out said assay: The invention relates to an assay method and a fluid microsystem for carrying out said assay method, in particular, for carrying out miniaturized affinity tests in a micro-array format. According to said invention, a liquid phase comprising at least one type of detectable high-molecular weight soluble substance, for example a... Agent: Helge Adleff

20080032405 - Standard/reference/control for blood coagulation testing: A whole-blood-based substitute composition that is useful in coagulation assays as a standard, reference, control, calibrator, linearity verifier, or training material is prepared by combining a red blood cell lysate that is free of plasma, leukocytes, and platelets with a platelet-free plasma of human origin and an antimicrobial agent.... Agent: Townsend And Townsend And Crew, LLP

20080032408 - Tag nucleic acids and probe arrays: The invention provides a unique set of nucleic acid sequences which is appropriate for use for a wide variety of applications requiring nucleic acid tags. As such, the sequence tags of the presently claimed invention may be used, for example, to label biological and nonbiological materials, in genotyping applications and... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20080032409 - Fluorescent biomolecule labeling reagents: The invention describes fluorescent biomolecule labeling reagents (I-SHark and phI-SHark) and their model compounds. Further described are methods of preparing and using the same.... Agent: Davis Wright Tremaine LLP/los Angeles

20080032406 - Methods for determining the origin of sucralose products: A method is provided for determining the origin of a sample of the artificial sweetener sucralose. Stable chlorine isotope analysis is used in the determination. Sucralose is sold under the trademark Splenda® by authorised manufacturers. The ability to determine the origin of a sample of sucralose is particularly useful to... Agent: Snell & Wilmer L.L.P. (main)

20080032407 - Sensor dispensing instrument having a pull/push activation mechanism: A sensor dispensing instrument adapted to handle a sensor pack containing a plurality of sensors and to perform a test using one of the sensors. The sensor dispensing instrument includes an outer housing and a mechanical mechanism contained therein for rotating the sensor pack and ejecting one of the sensors... Agent: Nixon Peabody LLP

20080032410 - Labeling for identification of proteins and other macromolecules: A method for identifying one or more proteins or other macromolecules comprises contacting the proteins or other macromolecules or a material that contains them with soluble fluorescent labels and/or Raman labels that bind to at least two different functional groups, side chains or moieties that may be present on or... Agent: Townsend And Townsend And Crew, LLP

20080032411 - Iconic colorimetric test device with reduced susceptibility to false positive and false negative readings: Laminated test devices in which positive results are detected by the appearance of a symbol on the surface of the device due to a color change in an indicator in the device are improved by placing the indicator lamina on one side of a light-transmissive substrate sheet and a pigment... Agent: Townsend And Townsend And Crew, LLP

20080032412 - Pharmaceutical mixture evaluation: A method for obtaining information about a heterogeneous pharmaceutical mixture is disclosed. The method includes beginning to apply an image enhancement agent to the mixture. A plurality of images of the mixture can then be obtained over time, with at least one image being obtained after the step of beginning... Agent: Kristofer E. Elbing

20080032414 - Sub-diffraction image resolution and other imaging techniques: The present invention generally relates to sub-diffraction image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated... Agent: Wolf Greenfield & Sacks, P.C.

20080032415 - Fluorescence detection method: Two or more target substances are simply and efficiently detected using one type of nanoparticle. Two or more target substances contained in one sample are labeled with two or more fluorescent dyes each capable of binding to the respective target substance and each of which emit light at wavelengths different... Agent: Taiyo Corporation

20080032416 - Miniaturized apparatus for real-time monitoring: The present invention relates to a apparatus for quantitative continuous real-time monitoring to monitor a continuous reaction of biochemical reagent and the reaction, such as DNA. More particularly, the present invention is directed to a miniaturized apparatus for real-time monitoring of biochemical reaction, which comprises capillary tubes (100) wherein biochemical... Agent: Nath & Associates

20080032413 - Oligonucleotide for detecting target dna or rna: An oligonucleotide that can be used for detecting the presence of a target DNA or RNA in a sample, a method for detecting a target DNA or RNA by using the oligonucleotide, and a kit comprising the oligonucleotide are provided. The oligonucleotide comprises a nucleoside labeled with a fluorophore and... Agent: Sughrue Mion, PLLC

20080032417 - Photocleavable isotope-coded affinity tags: This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as proteins and protein fragments from biological samples from in vivo and in vitro sources. Agents comprise a detectable group bound to a photoreactive group. Conjugates comprise agents coupled... Agent: Peter G. Carroll Medlen & Carroll, LLP

20080032418 - Cell free assay systems for identifying a substance of interest: The invention relates to an assay for determining if ligands bind to a receptor. The method involves the use of complexes, where the receptor is linked to a reporter molecule via an (His)n chain. When ligand binds to the receptor, the reporter molecule, which is preferably a peryline, yields a... Agent: Invitrogen Corporation C/o Intellevate

20080032419 - Binding evaluation method for macromolecular compound: A method for evaluating the binding of an evaluation target molecule with respect to a macromolecular compound based on numerical calculations and which detects the binding sites of the evaluation target molecule with respect to the macromolecular compound as a site where electronic states in a predetermined restricted region including... Agent: Ostrolenk Faber Gerb & Soffen

20080032420 - Surface enhanced raman scattering and multiplexed diagnostic assays: Multiplexed lateral flow assays, related methods, and devices are disclosed which are capable of simultaneously detecting multiple analytes. The assays are preferably immunoassays and can be multiplexed spatially, spectrally, and both spatially and spectrally. Multiplexed assays are disclosed employing quantum dots for applications including the detection of human proteins and... Agent: Greenlee Winner And Sullivan P C

20080032421 - Core-shell particles: Colloidal metal particles having a coating comprising non cross-linked, SH-activated dextran or aminodextran. Biomolecules may be linked directly or indirectly to the particles, which are useful as detection reagents in immunological assays.... Agent: Marilyn L. Amick Roche Diagnostic Corporation

20080032422 - System and method for detecting specific binding reactions using magnetic labels: A system and method for detecting specific binding reactions using magnetic labels.... Agent: Weiss & Weiss Suite 251

20080032423 - Gmr biosensor with enhanced sensitivity: A sensor array comprising a series connection of parallel GMR sensor stripes provides a sensitive mechanism for detecting the presence of magnetized particles bonded to biological molecules that are affixed to a substrate. The adverse effect of hysteresis on the maintenance of a stable bias point for the magnetic moment... Agent: Stephen B. Ackerman