Chemistry: analytical and immunological testing inventions 10/07

20070249053 - Ultra high molecular weight polyethylene fractions having narrow molecular weight distributions and methods of making and using the same: Polymer fractions such as polyethylene fractions can be produced that have a PDI less than about 2.3 and a Mw greater than about 1,000,000 g/mol, 3,000,000 g/mol, or 6,000,000 g/mol. Such polyethylene fractions are separated from a UHMWPE parent polymer by first dissolving the parent polymer in a relatively good... Agent: Chevron Phillips Chemical Company

20070249054 - Indication composition for surgical instrument cleaning evaluation: The present invention provides an indicator composition for evaluating cleaning of a medical instrument comprising an extracellular matrix component and hemoglobin, as a contamination model having cleaning profile resembling an actual contaminant adhered to a medical instrument such as a surgical instrument.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070249055 - Method of measuring lotion and additive ingredient transfer: A method of determining the amount of lotion and/or additive ingredients transferred from a lotion and/or additive ingredient containing fibrous structure to the skin of a wearer is provided. The method simulates actual wear of a fibrous structure, such as a feminine hygiene pad to produce an accurate measurement of... Agent: The Procter & Gamble Company Intellectual Property Division - West Bldg.

20070249057 - Menstrual fluid simulant: Menstrual fluid simulants may consistently emulate the physical characteristics of real menstrual fluid, including but not limited to, viscosity, stringiness, surface tension and size and concentration of particulate matter. In addition, the constituents comprising the menstrual fluid simulants may be changed in order to mimic the variations in real menstrual... Agent: The Procter & Gamble Company Intellectual Property Division - West Bldg.

20070249056 - Peptide and protein fragmentation by lysine residue originated reactions: A method of modifying protein samples that comprises combining the sample with a peroxycarbonate solution and inserting the sample into a mass spectrometer. The present invention also includes methods of N-terminus characterization.... Agent: Stites & Harbison PLLC

20070249058 - Hydrocarbon dewpoint measurement device and method: A method and system for determining a hydrocarbon dewpoint of natural gas in which a spherical acoustic resonator is filled with natural gas at a first temperature and pressure, where the first temperature is above the hydrocarbon dewpoint at the pressure. An acoustic signal is introduced into the natural gas... Agent: Mark E. Fejer Gas Technology Institute

20070249059 - Phase change sensor: A device is disclosed which is a highly sensitive and selective sensor. The device is comprised of a sensor material secured into a fixed position on substrate, a deformable arm and a signaling component which creates a detectable signal in response to movement of the arm. The sensitivity of the... Agent: Perkins Coie LLP

20070249060 - Determination of proteins and/or other molecules using mass spectroscopy: This invention generally relates to the determination of species such as proteins and/or small molecules on self-assembled monolayers using mass spectrometry. In some cases, the proteins and/or small molecules may be arranged on a substrate in an array, for example, in a microarray. In one set of embodiments, the invention... Agent: Wolf Greenfield & Sacks, P.C.

20070249061 - High-throughput screening method for intergrin antagonist and new peptide screened therefrom: The present invention relates to the screening method of antagonistic material of integrin using the protein chip and useful peptides screened thereby. The protein chip used in the present invention is unique substrate coated with new material, calixarene derivative, which can keep uniform and high activities of proteins. Integrin receptor... Agent: Welsh & Katz, Ltd

20070249062 - Microfluidic chip: A microfluidic chip used in latex agglutination for analyzing a small amount of liquid specimen with a latex reagent is provided, in order to suppress adsorption of latex particles into an inner wall surface of a latex reagent retaining chamber of the microfluidic chip, and to improve measuring precision of... Agent: Fish & Richardson P.C.

20070249063 - Biosensors: Methods for detecting a biological interaction comprising administering a substrate comprising a ligand attached to the substrate wherein the ligand binds to a receptor and wherein a signal is produced. Also disclosed is a biosensor comprising a substrate and a ligand wherein the ligand is attached to the surface of... Agent: Arent Fox PLLC

20070249064 - Quantum dots and their uses: Quantum dots having ligands that comprise tiopronin capping groups are disclosed, along with a method for their preparation. The biocompatibility of these quantum dots is also demonstrated. The functionalization of the quantum dots of the present invention with targeting groups is also described using the example of a translocation peptide... Agent: Dann, Dorfman, Herrell & Skillman

20070243618 - Device and method for non-invasive oxygen sensing of sealed packages: The present invention provides a system, method and composition for detecting exposure of the contents of a container to one or more gases using a gas sensitive package sensor. The gas sensitive package sensor includes a ruthenium-based luminescence indicator composition having a ruthenium-based luminescence compound having one or more optical... Agent: Chalker Flores, LLP

20070243619 - Method of testing denitration catalyst: The present invention provides a method of testing an NOx removal catalyst, which method enables assessment of actual catalytic performance in consideration of gas flow condition in the gas conduits of the NOx removal catalyst. The method of testing a honeycomb-form NOx removal catalyst for use in a flue gas... Agent: Sughrue Mion, PLLC

20070243620 - Analysis and screening of solid forms using the atomic pair distribution function: A method that comprises providing a PDF trace of a first sample of a substance, providing a PDF trace of a second sample of the substance, and comparing the PDF traces to determine whether the substance of the first sample and the substance of the second sample have the same... Agent: Finnegan, Henderson, Farabow, Garrett & Dunner LLP

20070243621 - Method and device to detect therapeutic protein immunogenicity: The present invention consists of a time-temperature indicator device that has at least one parameter set to warn when a therapeutic protein drug has had a thermal history associated with increased risk of unwanted immunological activity. The indicator device is designed to remain with the drug as the drug travels... Agent: Stephen E. Zweig

20070243622 - Polymeric sulfated surfactants for capillary electrophoresis (ce) and ce-mass spectrometry (ce-ms): The present invention relates generally to sulfated micelle compositions, methods of manufacture, and applications thereof. In particular, the micelles of the present invention provide an efficient enantiomeric separation and detection techniques for use in capillary electrophoresis and capillary electrophoresis with mass spectrometry.... Agent: Sutherland Asbill & Brennan LLP

20070243623 - Device for the presentation of peptides or proteins, method for the preparation and use thereof: The invention relates to a device for the presentation of polypeptides, a method for the preparation and the use thereof, as diagnostic tool (polypeptide chip) for miniaturized and highly parallel detection of structurally or functionally complementary molecules of said polypeptides, i.e. antibodies.... Agent: Oblon, Spivak, Mcclelland, Maier & Neustadt, P.C.

20070243624 - Hydrogen emission reporting system and method thereof: The present invention provides a system and method for monitoring and reporting the controlled and uncontrolled emissions of hydrogen gas from an end use application such as a hydrogen cooled electrical generator. The system first determines a quantity hydrogen produced by a hydrogen conversion device from a first operating parameter.... Agent: Proton Energy System

20070243625 - Histamine detection method and histamine detection kit: The histamine detection method of the invention includes: a reaction step of causing a sample solution possibly containing histamine to react with 2,3-naphathalene dicarboxylaldehyde at PH of less than 10; and a detection step of detecting histamine based on a color change in the reaction step. The arrangement of this... Agent: Oliff & Berridge, PLC

20070243626 - System and method for histological tissue specimen processing: A method of managing resources of a histological tissue processor, the tissue processor comprising at least one retort (12, 14) selectively connected for fluid communication to at least one of a plurality of reagent resources (26) by a valve mechanism (40), the method comprising the step of: nominating resources according... Agent: Sughrue Mion, PLLC

20070243627 - Computerized control method and system for microfluidics and computer program product for use therein: Microfluidic devices having active features such as valves, peristaltic pumps, and mixing portions are fabricated to have a thin elastomeric membrane over the active features. The active features are activated by a tactile actuator external to the membrane. A computer executes software for controlling the actuators. The software may include... Agent: Brooks Kushman P.C.

20070243628 - Immunoassay product and process: A rapid, efficient and convenient method to detect one or more biological entities on a blotting membrane is provided. The detection can relate to the position, nature or amount of the biological substance on one or more membranes. The invention method involves a pressure assisted regiment (such as vacuum or... Agent: Millipore Corporation

20070243631 - Determination of concentration of fk778 by competitive immunoassay: Methods and kits for measurement of concentration of FK778 in a biological sample by means of an immunoassay, preferably a competitive immunoassay. In one aspect, the method and kit involve the use of (a) an antibody to FK778 conjugated to a label, e.g., an acridinium label, (b) an antibody to... Agent: Robert Deberardine Abbott Laboratories

20070243629 - High affinity ligands for influenza virus and methods for their production: The present invention relates to long branched poly-N-acetyllactosamines and analogous spacer modified divalent sialosides binding to the large binding site of influenza hemagglutinin. The invention further relates to the method for evaluating the potential of a chemical entity to bind to a molecule or molecular complex comprising a large binding... Agent: Birch Stewart Kolasch & Birch

20070243630 - Quantitative lateral flow assays and devices: This invention provides solid phase specific binding lateral flow assay methods, devices and kits for quantitating high and low molecular weight analytes. The methods and devices of the invention employ labelled reagents which are either analyte analogs or complementary specific binding pair members for the analyte and a novel arrangement... Agent: Morrison & Foerster LLP

20070243632 - Methods for measuring platelet reactivity of patients that have received drug eluting stents: A method is providing for measuring platelet reactivity of a PCI patient that has a (DES). A blood sample is obtained from the patient. The blood sample is mixed in combination with 1) an anticoagulant; 2) sufficient buffer to maintain the pH and salt concentration of the anticoagulated blood within... Agent: Heller Ehrman LLP

20070243634 - Droplet-based surface modification and washing: The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of providing a droplet in contact with a surface with a reduced concentration of a substance is provided, wherein the method includes: (a) providing a droplet microactuator comprising a surface in contact with a... Agent: Ward And Smith, P.A.

20070243633 - Biosensor: An object of the present invention is to provide a biosensor which exhibits good reproducibility of the amount of an immobilized physiologically active substance by suppressing plane deterioration (separation of a metal film from a resin) which occurs at the formation of a thin metal film layer on a resin... Agent: Sughrue Mion, PLLC

20070243635 - Method and apparatus for mass spectrometric immunoassay analysis of specific biological fluid proteins: Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins and their variants that are present in complex biological fluids or extracts. Protein and variant levels can be determined using quantitative methods in which the protein/variant signals are normalized to signals of internal reference standard... Agent: Snell & Wilmer L.L.P. (main)

20070243636 - Method and apparatus for mass spectrometric immunoassay analysis of specific biological fluid proteins: Presented herein are methods, devices and kits for the mass spectrometric immunoassay (MSIA) of proteins and their variants that are present in complex biological fluids or extracts. Protein and variant levels can be determined using quantitative methods in which the protein/variant signals are normalized to signals of internal reference standard... Agent: Snell & Wilmer L.L.P. (main)

20070243637 - Process and device for determining the concentrations of ligands: In a process for determining the concentrations of ligands (9, 10) in a sample to be analyzed, ligands (9) of a first ligand type are bond-specific for receptors (6) of a first receptor type, and ligands (10) of a second ligand type are bond-specific for receptors (8) of a second... Agent: The Webb Law Firm, P.C.

20070238180 - System and method for estimating filtrate contamination in formation fluid samples using refractive index: A method and apparatus is described for estimating terminal purity or terminal contamination for a fluid during the withdrawal of the fluid from a subsurface formation. The apparatus and method provide for measuring refractive index of the fluid over a time period, fitting a curve through the refractive index measurements... Agent: Madan, Mossman & Sriram, P.C.

20070238181 - Method and apparatus for monitoring the properties of a biological or chemical sample: A method of monitoring the properties of a biological or chemical sample. The method comprises: a) carrying out a plurality of different tests on the sample to generate corresponding test data, b) optionally carrying out a preliminary processing of the test data to generate partially processed data, c) storing the... Agent: Oliff & Berridge, PLC

20070238182 - Compositions and methods for the detection, diagnosis and therapy of hematological malignancies: Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an... Agent: Seed Intellectual Property Law Group PLLC

20070238183 - Methods for assessment of cardiovascular disease risk: Methods are provided for more accurately assessing cardiovascular disease (CVD) risk factors in individuals or populations, using a bimodal analysis including cholesterol-based CVD risk markers together with serum triglyceride levels. Preferably, if a CVD marker (e.g., the ratio of total cholesterol to HDL) yields high risk factors, these factors may... Agent: Hovey Williams LLP

20070238184 - Amyloid beta protein channel structure and uses thereof in identifying potential drug molecules for neurodegenerative diseases: The present invention relates to a novel channel structure of human amyloid beta protein (AbP) in lipid membranes and a rapid, quantitative and specific assay for screening test compounds, such as drugs, ligands (natural or synthetic), proteins, peptides and small organic molecules for their ability to bind and block the... Agent: Beyer Weaver LLP

20070238185 - Oxide layers on silicon substrates for effective confocal laser microscopy: Methods of performing confocal laser microscopy on a polymer array disposed on a silicon wafer substrate, the method comprising the steps of providing a silicon wafer substrate having a top side and a bottom side, coating the top side of the silicon wafer with an oxide coating to provide an... Agent: Affymetrix, Inc Attn: ChiefIPCounsel, Legal Dept.

20070238186 - Nanowire-based system for analysis of nucleic acids: System for detection and/or analysis of nucleic acids using nanowires to detect covalent modification of nucleic acids.... Agent: Kolisch Hartwell, P.C.

20070238187 - Method to identify or evaluate compounds useful in the field of fragrances and aromas: The invention relates to methods of identification or evaluation of compounds useful in the field of fragrances and aromas (the volatile part of a flavour). Methods according to the invention take into account the occurrence of enzymatic metabolism in the human respiratory tract, including the oral and in particular the... Agent: Curatolo Sidoti Co., Lpa

20070238188 - Peroxide monitor: The presence and amount of hydrogen peroxide in a liquid can be determined by breaking down hydrogen peroxide into water and oxygen gas. By monitoring a base level of dissolved oxygen and comparing that to the amount of oxygen after breaking down the hydrogen peroxide, one can determine the amount... Agent: Trop Pruner & Hu, PC

20070238189 - Method of analyzing carbon concentration in crystalline silicon: A method of analyzing carbon concentration in crystalline silicon includes providing a section from a zoned and annealed silicon core. The zoned and annealed core is extracted from a polycrystalline silicon composition and has a columnar shape. The zoned and annealed core includes a single crystalline silicon region and a... Agent: Howard & Howard Attorneys, P.C.

20070238190 - Method of authenticating a poly(arylene ether) composition: A poly(arylene ether)-containing resin composition or article may be authenticated by a method that includes at least partially extracting a pH sensitive compound from the resin composition or the article with a solvent, wherein the resin composition or the article includes a poly(arylene ether) and the pH sensitive compound; mixing... Agent: Cantor Colburn, LLP

20070238191 - Honeycomb filter defect detecting method and apparatus: A apparatus and method for detecting defects in a honeycomb body. In operation, the particulates emerge at an outlet end face of the honeycomb body through defects, if any, in the honeycomb walls and/or plugs and passes though a permeable member, such as a screen, where they are illuminated. The... Agent: Corning Incorporated

20070238192 - Methods and apparatus for detecting exposure to hazardous substances: An apparatus for detecting exposure to at least one hazardous substance is provided. The apparatus includes a body having a plurality of openings, and an attachment mechanism coupled to the body. Each opening is sized to receive a cassette for detecting the presence or absence of at least one hazardous... Agent: Patrick W. Rasche Armstrong Teasdale LLP

20070238193 - Apparatus and method for filtration to enhance the detection of peaks: Filters and methods for enhancing the identification of peaks is disclosed. In particular, the invention encompasses methods using hole array filters for the purpose of purifying biological fluids to be used in generating mass spectra data.... Agent: Howrey LLP

20070238195 - Conformational and topological protein regulation: Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the... Agent: Quine Intellectual Property Law Group, P.C.

20070238194 - Nuclear matrix protein alterations associated with colon cancer and colon metastasis to the liver and uses thereof: Proteins useful in the diagnosis of proliferative disorders of the colon are present in nuclear matrix protein preparations and can be characterized by molecular weight, isoelectric point, and amino acid sequence. The proteins may be identified, for example, by 2D-gel electrophoresis or by specific binding partners, such as antibodies.... Agent: Foley And Lardner LLP Suite 500

20070238196 - Methods of using an equine fc epsilon receptor alpha chain protein: The present invention relates to equine Fc epsilon receptor alpha chain nucleic acid molecules, proteins encoded by such nucleic acid molecules, antibodies raised against such proteins, and inhibitors of such proteins. The present invention also includes methods to detect IgE using such proteins and antibodies. Also included in the present... Agent: Heska Corporation Intellectual Property Dept.

20070238197 - Fluorescent ligands for gpcr arrays: Microarrays employing a fluorescent ligand including a material having a binding affinity in the range of about 0.01 to about 25 nM, or about 0.1 to about 10 nM; a specificity to its cognate receptor in the range of about 50 to about 99%, or about 65 to about 99%;... Agent: Kaplan Gilman Gibson & Dernier L.L.P.

20070231913 - Method and apparatus for measuring hematological sample: A measuring method and a measuring apparatus which can classify and count myeloblast more precisely without influence of other component in a sample including platelet aggregation in measurement of a blood sample with a flowcytometry, wherein damage is given to a cell membrane of erythrocyte and mature leukocyte contained in... Agent: Sughrue Mion, PLLC

20070231909 - Methods for the development of a biomolecule assay: The present teachings provide methods for the development of a mass spectrometric based assay for a protein in a sample using parent-daughter ion transition monitoring (PDITM). In various aspects, the present teachings provide methods for developing a mass spectrometric based assay for a protein in a sample without the use... Agent: Choate, Hall & Stewart LLP

20070231910 - Titration method using a tracer to quantify the titrant: A titration method uses a tracer in the titrant or titrand to quantify the amount of titrant added. The method does not require quantitative addition of titrant or sample. The tracer can be inert or can participate as an indicator of the titrant-analyte reaction. The tracer concentration is quantified by... Agent: Jean Kyle

20070231912 - Method for determining asphaltenes contamination in used marine engine lubricants using uv-visible spectroscopy and chemometrics: A method for determining contamination in marine diesel lubricating oils. The method has been found to have particular utility in estimating asphaltenes contamination in marine diesel lubricating oils. The method includes the steps of: (a) obtaining spectral raw data over a frequency range substantially equivalent to that of ultraviolet-visible light... Agent: Exxonmobil Research & Engineering Company

20070231911 - Thermomechanical sensor for fluid diagnostics: A method for diagnosing a fluid includes sensing a property of the fluid and the temperature of the fluid at the time the property is sensed, then determining the status of the fluid from the sensing. The sample volume may be small in comparison to the total fluid volume.... Agent: Koppel, Patrick & Heybl

20070231914 - Methods for performing hematocrit adjustment in glucose assays and devices for same: calculating the percent hematocrit, % Hctc, of the blood sample; determining whether to adjust the glucose value, Glum, to an adjusted glucose value, Gluadj; and using the percent hematocrit, % Hctc, and either the glucose value, Glum, or the adjusted glucose value, Gluadj, to adjust for any bias of the... Agent: Nixon Peabody LLP

20070231915 - Apparatus and method for filtration to enhance the detection of peaks: Filters and methods for enhancing the identification of peaks is disclosed. In particular, the invention encompasses methods using hole array filters for the purpose of purifying biological fluids to be used in generating mass spectra data.... Agent: Howrey LLP

20070231916 - Apparatus and method for filtration to enhance the detection of peaks: Filters and methods for enhancing the identification of peaks is disclosed. In particular, the invention encompasses methods using hole array filters for the purpose of purifying biological fluids to be used in generating mass spectra data.... Agent: Howrey LLP

20070231917 - Apparatus and method for filtration to enhance the detection of peaks: Filters and methods for enhancing the identification of peaks is disclosed. In particular, the invention encompasses methods using hole array filters for the purpose of purifying biological fluids to be used in generating mass spectra data.... Agent: Howrey LLP

20070231918 - Devices with surface bound ionic liquids and method of use thereof: An ionic liquid bound on an exposed surface of a device such as for detecting organic chemicals, preferably a gas sensor is described. The gas sensor can operate at high temperatures with a fast linear response which is also reversible. At high temperatures, the frequency change (Δf) versus concentration (C)... Agent: Ian C. Mcleod Ian C. Mcleod, P.C.

20070231920 - Method of determining chelating agent and determination kit for chelating agent: The concentration of a water treating agent can be simply understood on site where thermal equipment is placed. A method of determining a chelating agent according to the present invention includes the steps of: collecting a water sample; adding a first chemical solution containing a metal indicator and a second... Agent: Birch Stewart Kolasch & Birch

20070231919 - Method for detecting the effect of a toxic substance using sub-mitochondrial particle: Disclosed herein is a method for detecting the effect of a toxic substance using sub-mitochondrial particle (SMP) comprising contacting a sub-mitochondrial particle with a sample; adding an external electron donor to the sample; measuring a pH change; and correlating the pH change with a concentration of the toxic substance in... Agent: Cantor Colburn, LLP

20070231921 - Method and system for determining whether a drug will be effective on a patient with a disease: A process of determining whether a patient with a disease or disorder will be responsive to a drug, used to treat the disease or disorder, including obtaining a test spectrum produced by a mass spectrometer from a serum produced from the patient. The test spectrum may be processed to determine... Agent: Patton Boggs, L.L.P.

20070231922 - Assay test strips with multiple labels and reading same: In one aspect, an assay test strip includes a test label that specifically binds a target analyte and a control label that is free of any specific binding affinity for the target analyte and has a different optical characteristic than the test label. In another aspect, an assay test strip... Agent: Kathy Manke Avago Technologies Limited

20070231923 - Sampling device and method for the rapid detection of specific molds, allergens, viruses, fungi, bacteria and other protein containing substances: Provided is sampling and testing device for the detection of specific molds, allergens, viruses, bacteria, fungi, and other protein containing substances. Embodiments of the device include a sampling member slideably engaged with a base that contains a lateral flow strip adapted to detect specific analytes of interest. The sampling member... Agent: The Clorox Company

20070231924 - Method and apparatus for assay in utilizing attenuated total reflection, and sample immobilizing device: A sensor unit for assay in utilizing surface plasmon resonance (SPR) includes a dielectric prism. Metal film has a light entrance surface fitted on the prism, and a sensing surface reverse to the light entrance surface. The sensing surface is adapted to causing interaction between ligand of ligand liquid and... Agent: Sughrue Mion, PLLC

20070231925 - Methods and devices for protein assays: Methods and devices for protein assays based on Edman degradation in microfluidic channels are disclosed herein. As disclosed, the cleaved amino acid residues may be immobilized in an array format and identified by detectable labels, such as antibodies, which specifically bind given amino acid residues. Alternatively, the antibodies are immobilized... Agent: Smith, Gambrell & Russell (snl)

20070231926 - Sensor element and detection method of magnetic particles using this element, and detection method of target substance: A sensor device is configured by using a sensor element including functions as a magnetic field sensor and capable of generating the magnetic field for collecting magnetic particles on a sensor surface by the application of the current. As a result, a sensor device can be provided in which the... Agent: Fitzpatrick Cella Harper & Scinto